Search of human proteins with 147904700

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|147904700 semaphorin 5A [Homo sapiens]
         (1074 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|147904700 semaphorin 5A [Homo sapiens]                            2300   0.0  
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                   1367   0.0  
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   310   6e-84
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    302   1e-81
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          295   2e-79
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          295   2e-79
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          295   2e-79
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          295   2e-79
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          295   2e-79
gi|16306552 semaphorin Y [Homo sapiens]                               277   3e-74
gi|157388902 semaphorin 4C [Homo sapiens]                             274   4e-73
gi|118572606 hemicentin 1 [Homo sapiens]                              272   1e-72
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     266   8e-71
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          261   3e-69
gi|21361914 semaphorin B [Homo sapiens]                               253   9e-67
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]           252   1e-66
gi|6912650 semaphorin 3E [Homo sapiens]                               251   2e-66
gi|5454048 semaphorin 3C [Homo sapiens]                               249   8e-66
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   249   1e-65
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]          248   2e-65
gi|41406086 semaphorin 3D [Homo sapiens]                              248   3e-65
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   243   5e-64
gi|39777610 semaphorin 4B precursor [Homo sapiens]                    240   6e-63
gi|39777608 semaphorin 4B precursor [Homo sapiens]                    240   6e-63
gi|188497703 semaphorin 3F [Homo sapiens]                             238   3e-62
gi|19923279 semaphorin W [Homo sapiens]                               212   2e-54
gi|28872814 semaphorin 4G [Homo sapiens]                              197   4e-50
gi|9910362 semaphorin sem2 [Homo sapiens]                             191   4e-48
gi|4505737 complement factor properdin precursor [Homo sapiens]       183   7e-46
gi|223671861 complement factor properdin precursor [Homo sapiens]     183   7e-46

>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score = 2300 bits (5960), Expect = 0.0
 Identities = 1074/1074 (100%), Positives = 1074/1074 (100%)

Query: 1    MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQ 60
            MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQ
Sbjct: 1    MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQ 60

Query: 61   LTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRV 120
            LTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRV
Sbjct: 61   LTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRV 120

Query: 121  LLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELY 180
            LLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELY
Sbjct: 121  LLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELY 180

Query: 181  AATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH 240
            AATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH
Sbjct: 181  AATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH 240

Query: 241  DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL 300
            DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL
Sbjct: 241  DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL 300

Query: 301  DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTV 360
            DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTV
Sbjct: 301  DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTV 360

Query: 361  DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHII 420
            DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHII
Sbjct: 361  DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHII 420

Query: 421  YLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVV 480
            YLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVV
Sbjct: 421  YLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVV 480

Query: 481  KIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVD 540
            KIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVD
Sbjct: 481  KIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVD 540

Query: 541  GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTP 600
            GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTP
Sbjct: 541  GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTP 600

Query: 601  WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWG 660
            WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWG
Sbjct: 601  WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWG 660

Query: 661  PWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISD 720
            PWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISD
Sbjct: 661  PWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISD 720

Query: 721  NGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSA 780
            NGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSA
Sbjct: 721  NGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSA 780

Query: 781  HTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPV 840
            HTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPV
Sbjct: 781  HTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPV 840

Query: 841  DGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWS 900
            DGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWS
Sbjct: 841  DGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWS 900

Query: 901  EWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEE 960
            EWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEE
Sbjct: 901  EWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEE 960

Query: 961  KRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITN 1020
            KRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITN
Sbjct: 961  KRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITN 1020

Query: 1021 HINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY 1074
            HINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
Sbjct: 1021 HINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY 1074


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score = 1367 bits (3539), Expect = 0.0
 Identities = 616/1043 (59%), Positives = 780/1043 (74%), Gaps = 6/1043 (0%)

Query: 30   CQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI 89
            C  ++HP ++++++ PW+  F    A DFSQL  DP   +L+VGARNYLFRL L ++SL+
Sbjct: 98   CALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLL 157

Query: 90   QAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLT 149
            QA EW   E T+++C SKGK++EECQNY+RVL+V G ++F CGTNAF+P+CT+R + NL+
Sbjct: 158  QATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLS 217

Query: 150  EIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
               ++I+G+ARCPY P+HNSTA++++ GELYAAT +DF GRDPAIYRSLG  PPLRTAQY
Sbjct: 218  RTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQY 277

Query: 210  NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWT 269
            NSKWLNEPNFV++YDIG F YFF RENAVEHDCG+TV+SR ARVCKND+GGRFLLEDTWT
Sbjct: 278  NSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWT 337

Query: 270  TFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQ 329
            TFMKARLNCSRPGEVPFYYNELQS F LPE DLIYG+FTTNVNSIAASAVC FNLSAI+Q
Sbjct: 338  TFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQ 397

Query: 330  AFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQ-GLYVNLTERNLQDAQKFILMHEVVQP 388
            AF+GPF+YQEN R+AWLP  NP P+FQCGT+ + G   NLTER+LQDAQ+  LM E VQP
Sbjct: 398  AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQP 457

Query: 389  VTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEI 448
            VT  P   +D+ RFSH+ VD+VQ ++ L H++Y+ T+ GTI K     +++   C LEE+
Sbjct: 458  VTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEEL 517

Query: 449  ELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDV 508
             + P  RREP+RSL+ILHS   LFVGLR+ V+++PL+RC  YR++  C+GA+DPYCGWD 
Sbjct: 518  HVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDG 577

Query: 509  VMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTR 568
              ++C++LE+S +M+ W Q+I+ACP RN+T DG FG WSPW PC H DG   GSCLCR R
Sbjct: 578  KQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRAR 637

Query: 569  SCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPR 628
            SCDSP P+CGG  C GP + IANCSRNG WTPW+SW+ CST+CGIGFQVRQRSCSNP PR
Sbjct: 638  SCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPR 697

Query: 629  HGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAG 688
            HGGR+CVG++REER+CNE+  CP  +FW  WG W +C++ CGGG+Q+RRR CENG  C G
Sbjct: 698  HGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLG 757

Query: 689  CNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQ 748
            C VE+++CN   CPE+++ TPWTPW PVN++  G   EQRFR+TC+A LADP+ L+ GR+
Sbjct: 758  CGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRR 817

Query: 749  RIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRK 808
            R E R C +DG+  C TD L    LR+G  S HTV+G W+AW  WS CSRDC  G R RK
Sbjct: 818  RTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRK 877

Query: 809  RVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSC 868
            R C NPEP+ GG+PC+G + EYQ+CN   CPV G WSCW+ W+ CSA+CGGGHY RTRSC
Sbjct: 878  RTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSC 937

Query: 869  SNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPMGS 928
            ++PAP+ G DICLGLHTEEALC TQ CPE WS WS+WS+C   G Q R+R C  L P  S
Sbjct: 938  TSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSS 997

Query: 929  QCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLL 988
             C+GN+++SRPC +    IP V +  SS  E   C  FN+ H++A G+S  +   LLTL 
Sbjct: 998  ACAGNSSQSRPCPYSE--IP-VILPASSMEEATDCAGFNLIHLVATGISCFLGSGLLTLA 1054

Query: 989  VYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERN 1048
            VY  CQ  Q+QS ++T++HP +P  L+        K +KY  +E  K  NKNNLI ++R 
Sbjct: 1055 VYLSCQHCQRQSQESTLVHPATPNHLHYK-GGGTPKNEKYTPME-FKTLNKNNLIPDDRA 1112

Query: 1049 KYFNPHLTGKTYSNAYFTDLNNY 1071
             ++    T    +  Y + LN +
Sbjct: 1113 NFYPLQQTNVYTTTYYPSPLNKH 1135


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  310 bits (793), Expect = 6e-84
 Identities = 195/530 (36%), Positives = 285/530 (53%), Gaps = 44/530 (8%)

Query: 70  LVVGARNYLFRLQL-----EDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLV- 123
           L + AR++++ + +     E++   + + W+  +A    C  KGK K+EC N+I+VLL  
Sbjct: 68  LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKK 127

Query: 124 GGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
             D LF CGTNAF P C N  +  L    D+ SGMARCPY  +H + AL  A G+LY+AT
Sbjct: 128 NDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALF-ADGKLYSAT 186

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHD-C 242
             DF   D  IYRSLG  P LRT +++SKWL EP FV + D G++ YFFFRE AVE++  
Sbjct: 187 VTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTM 246

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL- 300
           GK VF R A+VCKND+GG + +LE  WT+F+KARLNCS PG+  FY+N LQ+   +  + 
Sbjct: 247 GKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRIN 306

Query: 301 --DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
             D++   F+T  NSI  SAVC +++  IA  F+G FK Q++  S W P P+   P P  
Sbjct: 307 GRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRP 366

Query: 356 QCGTVDQGLYVNLTERNL-QDAQKFI----LMHEVVQPVTTVPSFMEDNSRF--SHVAVD 408
            C      L    T      D   FI    LM E V  +   P F+    R+  + +AVD
Sbjct: 367 GCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVD 426

Query: 409 VVQGREALVHIIYLATDYGTIKKVRVPLNQT---SSSCLLEEIELFPERR-------REP 458
              G      +++L ++ G I K    +  +   + S  LEE+ ++   +        + 
Sbjct: 427 TAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKR 486

Query: 459 IRSLQILHSQSVLFVGLREHVVKIPLKRCQFY-RTRSTCIGAQDPYCGWDVVMKKCTSLE 517
           I  +Q+  + S L+V     V+K+PL RC+ + + + TCI ++DPYCGW      C+ L 
Sbjct: 487 IMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLS 546

Query: 518 ESLSMTQWEQSISA--------CPTRNLTVDGHFGVWSPWTPCTHTDGSA 559
            +  +T +EQ I          C    + ++GH     P T  T +D +A
Sbjct: 547 PNSRLT-FEQDIERGNTDGLGDCHNSFVALNGHSSSLLPST--TTSDSTA 593


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  302 bits (774), Expect = 1e-81
 Identities = 193/505 (38%), Positives = 271/505 (53%), Gaps = 39/505 (7%)

Query: 68  KELVVGARNYLFRLQLE-----DLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLL 122
           + L +G R+ L+R++LE     +L   + + W  + +    C  KGK + EC+N+++VLL
Sbjct: 75  RTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLL 134

Query: 123 VGGDR-LFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYA 181
           +  +  LF CG+NAF PVC N S+  L  + D ISGMARCPY P+H + AL +  G L+ 
Sbjct: 135 LRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFS-DGMLFT 193

Query: 182 ATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHD 241
           AT  DF   D  IYRSLG  P LRT +++SKW  EP FV + + G+  YFFFRE A+E +
Sbjct: 194 ATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFN 253

Query: 242 -CGKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPE 299
              K V SR ARVCKND+GG   +LE  WT+F+KARLNCS PG+  FY+N LQ+   +  
Sbjct: 254 YLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVS 313

Query: 300 L---DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNP 353
           L    ++  +F+T  NSI  SAVC F+L+ +A  F G F+ Q++  S W P P    P P
Sbjct: 314 LGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRP 373

Query: 354 HFQCGTVDQGLYVNLTERNLQDAQKFI----LMHEVVQPVTTVPSFMEDNSR--FSHVAV 407
              C     G+  N +     D   F+    LM E V  +   P  +    R   + VAV
Sbjct: 374 RPGC-CAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAV 432

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTSS-----SCLLEEIELF-PERRREP--- 458
           DV  G      +++L ++ GT+ K  V  N ++S     S  LEE E + P+R   P   
Sbjct: 433 DVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGG 492

Query: 459 -----IRSLQILHSQSVLFVGLREHVVKIPLKRCQFYR-TRSTCIGAQDPYCGWDVVMKK 512
                + SL++  +   L       VV++P+ RCQ Y      CIG+QDPYCGW      
Sbjct: 493 ETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGW-APDGS 551

Query: 513 CTSLEESLSMTQWEQSISACPTRNL 537
           C  L    +   +EQ +S   T  L
Sbjct: 552 CIFLSPG-TRAAFEQDVSGASTSGL 575


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  295 bits (755), Expect = 2e-79
 Identities = 172/469 (36%), Positives = 260/469 (55%), Gaps = 34/469 (7%)

Query: 70  LVVGARNYLFRLQLEDLSLIQAVE-----WECDEATKKACYSKGKSKEECQNYIRVLLVG 124
           L +  R+ ++ + L ++   + +      W   +  ++ C  KGK K+EC N+I+V +  
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128

Query: 125 GDRL-FTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
            D + F CGTNAF P+C    LS L    ++ISG+ARCP+  +  + AL  A G+LY+AT
Sbjct: 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSAT 187

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DC 242
             DF   D  IYRS+G    LRT +Y+SKW+ EP+F+ + + GN+ YFFFRE AVEH + 
Sbjct: 188 VADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNL 247

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
           GK V+SR AR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + +++
Sbjct: 248 GKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQIN 307

Query: 302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
               + G+FTT +NSI  SAVC F++  I + F G FK Q+   S W   P    P P  
Sbjct: 308 GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

Query: 356 QCGTVDQGL------YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAV 407
            C     GL       ++  +  L   +   LM   V P+   P F +   R+  + ++V
Sbjct: 368 GC-CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISV 426

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELF-------PERRREP 458
           D   G      +I++ ++ G + KV    +  S   S LLEEIE +            + 
Sbjct: 427 DHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKK 486

Query: 459 IRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRT-RSTCIGAQDPYCGW 506
           + SLQ+      L+V     +++IPL RC+ Y + + +CI ++DPYCGW
Sbjct: 487 VISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  295 bits (755), Expect = 2e-79
 Identities = 172/469 (36%), Positives = 260/469 (55%), Gaps = 34/469 (7%)

Query: 70  LVVGARNYLFRLQLEDLSLIQAVE-----WECDEATKKACYSKGKSKEECQNYIRVLLVG 124
           L +  R+ ++ + L ++   + +      W   +  ++ C  KGK K+EC N+I+V +  
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128

Query: 125 GDRL-FTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
            D + F CGTNAF P+C    LS L    ++ISG+ARCP+  +  + AL  A G+LY+AT
Sbjct: 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSAT 187

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DC 242
             DF   D  IYRS+G    LRT +Y+SKW+ EP+F+ + + GN+ YFFFRE AVEH + 
Sbjct: 188 VADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNL 247

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
           GK V+SR AR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + +++
Sbjct: 248 GKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQIN 307

Query: 302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
               + G+FTT +NSI  SAVC F++  I + F G FK Q+   S W   P    P P  
Sbjct: 308 GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

Query: 356 QCGTVDQGL------YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAV 407
            C     GL       ++  +  L   +   LM   V P+   P F +   R+  + ++V
Sbjct: 368 GC-CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISV 426

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELF-------PERRREP 458
           D   G      +I++ ++ G + KV    +  S   S LLEEIE +            + 
Sbjct: 427 DHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKK 486

Query: 459 IRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRT-RSTCIGAQDPYCGW 506
           + SLQ+      L+V     +++IPL RC+ Y + + +CI ++DPYCGW
Sbjct: 487 VISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  295 bits (755), Expect = 2e-79
 Identities = 172/469 (36%), Positives = 260/469 (55%), Gaps = 34/469 (7%)

Query: 70  LVVGARNYLFRLQLEDLSLIQAVE-----WECDEATKKACYSKGKSKEECQNYIRVLLVG 124
           L +  R+ ++ + L ++   + +      W   +  ++ C  KGK K+EC N+I+V +  
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128

Query: 125 GDRL-FTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
            D + F CGTNAF P+C    LS L    ++ISG+ARCP+  +  + AL  A G+LY+AT
Sbjct: 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSAT 187

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DC 242
             DF   D  IYRS+G    LRT +Y+SKW+ EP+F+ + + GN+ YFFFRE AVEH + 
Sbjct: 188 VADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNL 247

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
           GK V+SR AR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + +++
Sbjct: 248 GKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQIN 307

Query: 302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
               + G+FTT +NSI  SAVC F++  I + F G FK Q+   S W   P    P P  
Sbjct: 308 GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

Query: 356 QCGTVDQGL------YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAV 407
            C     GL       ++  +  L   +   LM   V P+   P F +   R+  + ++V
Sbjct: 368 GC-CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISV 426

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELF-------PERRREP 458
           D   G      +I++ ++ G + KV    +  S   S LLEEIE +            + 
Sbjct: 427 DHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKK 486

Query: 459 IRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRT-RSTCIGAQDPYCGW 506
           + SLQ+      L+V     +++IPL RC+ Y + + +CI ++DPYCGW
Sbjct: 487 VISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  295 bits (755), Expect = 2e-79
 Identities = 172/469 (36%), Positives = 260/469 (55%), Gaps = 34/469 (7%)

Query: 70  LVVGARNYLFRLQLEDLSLIQAVE-----WECDEATKKACYSKGKSKEECQNYIRVLLVG 124
           L +  R+ ++ + L ++   + +      W   +  ++ C  KGK K+EC N+I+V +  
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128

Query: 125 GDRL-FTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
            D + F CGTNAF P+C    LS L    ++ISG+ARCP+  +  + AL  A G+LY+AT
Sbjct: 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSAT 187

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DC 242
             DF   D  IYRS+G    LRT +Y+SKW+ EP+F+ + + GN+ YFFFRE AVEH + 
Sbjct: 188 VADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNL 247

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
           GK V+SR AR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + +++
Sbjct: 248 GKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQIN 307

Query: 302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
               + G+FTT +NSI  SAVC F++  I + F G FK Q+   S W   P    P P  
Sbjct: 308 GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

Query: 356 QCGTVDQGL------YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAV 407
            C     GL       ++  +  L   +   LM   V P+   P F +   R+  + ++V
Sbjct: 368 GC-CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISV 426

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELF-------PERRREP 458
           D   G      +I++ ++ G + KV    +  S   S LLEEIE +            + 
Sbjct: 427 DHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKK 486

Query: 459 IRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRT-RSTCIGAQDPYCGW 506
           + SLQ+      L+V     +++IPL RC+ Y + + +CI ++DPYCGW
Sbjct: 487 VISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  295 bits (755), Expect = 2e-79
 Identities = 172/469 (36%), Positives = 260/469 (55%), Gaps = 34/469 (7%)

Query: 70  LVVGARNYLFRLQLEDLSLIQAVE-----WECDEATKKACYSKGKSKEECQNYIRVLLVG 124
           L +  R+ ++ + L ++   + +      W   +  ++ C  KGK K+EC N+I+V +  
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128

Query: 125 GDRL-FTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
            D + F CGTNAF P+C    LS L    ++ISG+ARCP+  +  + AL  A G+LY+AT
Sbjct: 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSAT 187

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DC 242
             DF   D  IYRS+G    LRT +Y+SKW+ EP+F+ + + GN+ YFFFRE AVEH + 
Sbjct: 188 VADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNL 247

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
           GK V+SR AR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + +++
Sbjct: 248 GKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQIN 307

Query: 302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
               + G+FTT +NSI  SAVC F++  I + F G FK Q+   S W   P    P P  
Sbjct: 308 GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

Query: 356 QCGTVDQGL------YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAV 407
            C     GL       ++  +  L   +   LM   V P+   P F +   R+  + ++V
Sbjct: 368 GC-CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISV 426

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELF-------PERRREP 458
           D   G      +I++ ++ G + KV    +  S   S LLEEIE +            + 
Sbjct: 427 DHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKK 486

Query: 459 IRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRT-RSTCIGAQDPYCGW 506
           + SLQ+      L+V     +++IPL RC+ Y + + +CI ++DPYCGW
Sbjct: 487 VISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  277 bits (709), Expect = 3e-74
 Identities = 177/474 (37%), Positives = 257/474 (54%), Gaps = 40/474 (8%)

Query: 68  KELVVGARNYLFRLQL------EDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVL 121
           + L+V AR+++F   L      E L   + + W   +     C  +GK  +EC NYIRVL
Sbjct: 71  RTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDVEN--CAVRGKLTDECYNYIRVL 128

Query: 122 LVGGDR-LFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELY 180
           +    + L  CGTN+F+PVC +  +++L +  +++SG ARCP+    ++ A+  A G LY
Sbjct: 129 VPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIF-AEGSLY 187

Query: 181 AATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH 240
           +ATA DF   D  +YRSLG  PPLR+A+Y+SKWL EP+FV + + G+  YFFFRE +VE 
Sbjct: 188 SATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFFREVSVED 247

Query: 241 -DCGKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEVPFYYNELQS---TF 295
              G+  FSR ARVCK D+GG    L+  WT+F+K RLNCS PG+  FY++ LQ+     
Sbjct: 248 ARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQALTGPV 307

Query: 296 FLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP-----YPN 350
            L     ++G+FTT  NSI  SAVC F L  I + F G FK Q +   AW P      P+
Sbjct: 308 NLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPS 367

Query: 351 PNPHFQCGTVDQGLYVNLTERNL-QDAQKFILMHEV----VQPVTTVPSF-MEDNSRFSH 404
           P P    G     L+   + R+L  D   FI  H +    V PVT  P   +   +  + 
Sbjct: 368 PRPGSCAGVGGAALF--SSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQ 425

Query: 405 VAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELFPERR------- 455
           VAVD + G  + + +++L ++ GT+ KV  P  ++      LLEEI+ +   R       
Sbjct: 426 VAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSGGPEPILLEEIDAYSPARCSGKRTA 485

Query: 456 --REPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFY-RTRSTCIGAQDPYCGW 506
                I  L++      LFV     +V +PL RC  +   + +C+ +QDPYCGW
Sbjct: 486 QTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGW 539


>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score =  274 bits (700), Expect = 4e-73
 Identities = 177/506 (34%), Positives = 257/506 (50%), Gaps = 36/506 (7%)

Query: 38  ISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECD 97
           +S  E+   +R F      DF  LT       L VGAR  LF   +E L L  A+ WE  
Sbjct: 33  VSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAP 92

Query: 98  EATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQI 155
              K  C  KGK+ + EC N+IR L       L+ CGT AF P CT  ++   T  H + 
Sbjct: 93  VEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEF 152

Query: 156 S-GMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWL 214
             G  +CPY P      LL   GELY+AT  +F G +P I R++G    ++T +Y + WL
Sbjct: 153 EDGKGKCPYDPAKGHAGLLV-DGELYSATLNNFLGTEPIILRNMGPHHSMKT-EYLAFWL 210

Query: 215 NEPNFVSSY----DIGNFT------YFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFL 263
           NEP+FV S      +G+FT      YFFFRE AVE DC  + V +R ARVCK D+GG   
Sbjct: 211 NEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGART 270

Query: 264 LEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAV 319
           L+  WTTF+KARL CS P     Y+N+LQ+   L +        +G+F      +  SA+
Sbjct: 271 LQRKWTTFLKARLACSAPNW-QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAI 329

Query: 320 CVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLY--------VNLTER 371
           C + L  I + F GP+K        W  Y +P P  + G+     +        + L + 
Sbjct: 330 CEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDN 389

Query: 372 NLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLATDYGTIK 430
            L   +K  LM E V P  + P  ++  + F+H+  D V G +   + ++++ T  G + 
Sbjct: 390 ILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLL 449

Query: 431 KVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFY 490
           K  V L       L+EE++LF +   EP+RSL +  S+ +LF G R  +V++P+  C  Y
Sbjct: 450 KA-VSLGPWVH--LIEELQLFDQ---EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY 503

Query: 491 RTRSTCIGAQDPYCGWDVVMKKCTSL 516
           R+ + C+ A+DPYC W V   +C ++
Sbjct: 504 RSCADCVLARDPYCAWSVNTSRCVAV 529


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  272 bits (695), Expect = 1e-72
 Identities = 139/369 (37%), Positives = 175/369 (47%), Gaps = 38/369 (10%)

Query: 539  VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSR---- 594
            V G F  WS W  C+ T G  +     R+R C+ P P  GG  C+G  +E+ NC      
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQK---RSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCP 4584

Query: 595  -NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPH 653
             +G W+ W+ W  C+ +CG G Q R R+C+NP+ +HGGR C G   E   CN    CP H
Sbjct: 4585 VDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRP-CPVH 4643

Query: 654  MFWTGWGPWERCTAQCGGGIQARRRICENGPD------CAGCNVEYQSCNTNPCPELKKT 707
              W+ W PW  C+  CG G Q R R+C N P       C G   + Q CN   CP   K 
Sbjct: 4644 GAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKW 4703

Query: 708  TPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDG 767
              W  W+  ++S  GG   QR R       +DP     GR+              C    
Sbjct: 4704 ATWASWSACSVSCGGGA-RQRTR-----GCSDPVPQYGGRK--------------CEGSD 4743

Query: 768  LSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPS 827
            +  DF  +     H   G WS W+ W  CSR C+ G   R R C+NP P  GG  C GP 
Sbjct: 4744 VQSDFCNSDPCPTH---GNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPD 4800

Query: 828  LEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEE 887
             + Q CN   CPVDG W  W  W++CSA+CGGG   R R C +P P  GG  C G  T+ 
Sbjct: 4801 SQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQV 4860

Query: 888  ALCNTQPCP 896
              CN Q CP
Sbjct: 4861 TRCNVQACP 4869



 Score =  246 bits (629), Expect = 6e-65
 Identities = 133/359 (37%), Positives = 168/359 (46%), Gaps = 37/359 (10%)

Query: 595  NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM 654
            +GG++ W++W  CS TCG G Q R R C+ P P +GG+ C G + E R C ++  CP   
Sbjct: 4529 HGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNC-QNKPCPVDG 4587

Query: 655  FWTGWGPWERCTAQCGGGIQARRRICEN------GPDCAGCNVEYQSCNTNPCPELKKTT 708
             W+ W  WE CT  CG G Q R R C N      G  C G  VE   CN  PCP     +
Sbjct: 4588 SWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWS 4647

Query: 709  PWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGL 768
             W PW   + S   G          +ARL +      G       YC    T        
Sbjct: 4648 AWQPWGTCSESCGKGTQT-------RARLCNNPPPAFGGS-----YCDGAETQ------- 4688

Query: 769  SGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSL 828
                ++        ++G W+ W SWS CS  C  G R R R C++P P+YGG  C G  +
Sbjct: 4689 ----MQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDV 4744

Query: 829  EYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEA 888
            +   CN  PCP  G WS WS W  CS TC GG   R R+C NP P+ GG  C G  ++  
Sbjct: 4745 QSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQ 4804

Query: 889  LCNTQPCPE--SWSEWSDWSECEAS---GVQVRARQCILLFPM--GSQCSGNTTESRPC 940
             CNT  CP   SW  W  WS+C AS   G + R R C    P+  G  C G+TT+   C
Sbjct: 4805 RCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRC 4863



 Score =  211 bits (538), Expect = 2e-54
 Identities = 110/319 (34%), Positives = 154/319 (48%), Gaps = 38/319 (11%)

Query: 532  CPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIAN 591
            C  +   VDG +  WS W  CT + G    +   RTR+C++P+ Q GG  CEG  +EI  
Sbjct: 4578 CQNKPCPVDGSWSEWSLWEECTRSCGRGNQT---RTRTCNNPSVQHGGRPCEGNAVEIIM 4634

Query: 592  CS-----RNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNE 646
            C+      +G W+ W  W  CS +CG G Q R R C+NP P  GG  C G   + + CNE
Sbjct: 4635 CNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNE 4694

Query: 647  HLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN------GPDCAGCNVEYQSCNTNP 700
               CP H  W  W  W  C+  CGGG + R R C +      G  C G +V+   CN++P
Sbjct: 4695 R-NCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDP 4753

Query: 701  CPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGT 760
            CP     +PW+ W   + + NGG   +R+R TC            G    +++ C++D  
Sbjct: 4754 CPTHGNWSPWSGWGTCSRTCNGGQM-RRYR-TCDNPPPSNGGRACGGPDSQIQRCNTD-- 4809

Query: 761  SGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGG 820
                                  V+G+W +W SWSQCS  C  G + RKR+C++P P  GG
Sbjct: 4810 -------------------MCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGG 4850

Query: 821  MPCLGPSLEYQECNILPCP 839
             PC G + +   CN+  CP
Sbjct: 4851 RPCPGDTTQVTRCNVQACP 4869



 Score =  168 bits (425), Expect = 3e-41
 Identities = 76/178 (42%), Positives = 99/178 (55%), Gaps = 12/178 (6%)

Query: 783  VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDG 842
            V+G+WS W+ W +C+R C RG + R R CNNP  ++GG PC G ++E   CNI PCPV G
Sbjct: 4585 VDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHG 4644

Query: 843  VWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP--ESWS 900
             WS W PW  CS +CG G   R R C+NP PA+GG  C G  T+  +CN + CP    W+
Sbjct: 4645 AWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWA 4704

Query: 901  EWSDWSECEAS---GVQVRARQCILLFPM--GSQCSGNTTE-----SRPCVFDSNFIP 948
             W+ WS C  S   G + R R C    P   G +C G+  +     S PC    N+ P
Sbjct: 4705 TWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHGNWSP 4762



 Score =  159 bits (403), Expect = 1e-38
 Identities = 74/165 (44%), Positives = 95/165 (57%), Gaps = 7/165 (4%)

Query: 783  VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDG 842
            V+G +S W++W  CS  C +GI+ R R+CN P P  GG PC G  LE + C   PCPVDG
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDG 4587

Query: 843  VWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP--ESWS 900
             WS WS W +C+ +CG G+  RTR+C+NP+  +GG  C G   E  +CN +PCP   +WS
Sbjct: 4588 SWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWS 4647

Query: 901  EWSDWSECEAS---GVQVRARQCILLFPM--GSQCSGNTTESRPC 940
             W  W  C  S   G Q RAR C    P   GS C G  T+ + C
Sbjct: 4648 AWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVC 4692



 Score =  149 bits (377), Expect = 1e-35
 Identities = 73/206 (35%), Positives = 99/206 (48%), Gaps = 15/206 (7%)

Query: 529  ISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGME 588
            I  C  R   V G +  W PW  C+ + G    +   R R C++P P  GG  C+G   +
Sbjct: 4632 IIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQT---RARLCNNPPPAFGGSYCDGAETQ 4688

Query: 589  I-----ANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERY 643
            +      NC  +G W  W SWS CS +CG G + R R CS+P P++GGR C G + +  +
Sbjct: 4689 MQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDF 4748

Query: 644  CNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPD------CAGCNVEYQSCN 697
            CN    CP H  W+ W  W  C+  C GG   R R C+N P       C G + + Q CN
Sbjct: 4749 CNSD-PCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCN 4807

Query: 698  TNPCPELKKTTPWTPWTPVNISDNGG 723
            T+ CP       W  W+  + S  GG
Sbjct: 4808 TDMCPVDGSWGSWHSWSQCSASCGGG 4833



 Score =  147 bits (371), Expect = 5e-35
 Identities = 68/188 (36%), Positives = 95/188 (50%), Gaps = 15/188 (7%)

Query: 526  EQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGP 585
            E  +  C  RN  + G +  W+ W+ C+ + G   G    RTR C  P PQ GG +CEG 
Sbjct: 4686 ETQMQVCNERNCPIHGKWATWASWSACSVSCG---GGARQRTRGCSDPVPQYGGRKCEGS 4742

Query: 586  GM--EIAN---CSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNRE 640
             +  +  N   C  +G W+PW+ W  CS TC  G   R R+C NP P +GGR C G + +
Sbjct: 4743 DVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQ 4802

Query: 641  ERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN------GPDCAGCNVEYQ 694
             + CN   +CP    W  W  W +C+A CGGG + R+R+C++      G  C G   +  
Sbjct: 4803 IQRCNTD-MCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVT 4861

Query: 695  SCNTNPCP 702
             CN   CP
Sbjct: 4862 RCNVQACP 4869


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  266 bits (680), Expect = 8e-71
 Identities = 166/493 (33%), Positives = 262/493 (53%), Gaps = 46/493 (9%)

Query: 54  NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKS-KE 112
           N+  +     D  +  L VGA++++F   L ++   Q + W      +  C   GK   +
Sbjct: 53  NSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILK 112

Query: 113 ECQNYIRVLLVGGD-RLFTCGTNAFTPVCTNRSLSNLTEIHDQI---------SGMARCP 162
           EC N+I+VL       L+ CGT AF P+CT   + +  E  D I         +G  + P
Sbjct: 113 ECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPE--DNIFKLENSHFENGRGKSP 170

Query: 163 YSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSS 222
           Y P+   TA L   GELY+ TA DF GRD AI+R+LG   P+RT Q++S+WLN+P F+S+
Sbjct: 171 YDPKL-LTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISA 229

Query: 223 YDIG-------NFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKA 274
           + I        +  YFFFRENA++ +  GK   +R  ++CKND GG   L + WTTF+KA
Sbjct: 230 HLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKA 289

Query: 275 RLNCSRPGE--VPFYYNELQSTFFL----PELDLIYGIFTTNVNSIAASAVCVFNLSAIA 328
           RL CS PG   +  +++ELQ  F +    P+  ++YG+FTT+ N    SAVC++++S + 
Sbjct: 290 RLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVR 349

Query: 329 QAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNL-TERNLQD-----AQKFILM 382
           + F GP+ +++     W+PY    P+ + GT     +    + ++L D     A+    M
Sbjct: 350 RVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAM 409

Query: 383 HEVVQPVTTVPSFMED--NSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQT- 439
           +  V P+   P  ++   N +F+ + VD V   +    ++++ TD GT+ KV     +T 
Sbjct: 410 YNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETW 469

Query: 440 --SSSCLLEEIELFPERRREP--IRSLQILHSQSVLFVGLREHVVKIPLKRCQFY-RTRS 494
                 LLEE+ +F    REP  I ++++   Q  L++G    V ++PL RC  Y +  +
Sbjct: 470 YDLEEVLLEEMTVF----REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACA 525

Query: 495 TCIGAQDPYCGWD 507
            C  A+DPYC WD
Sbjct: 526 ECCLARDPYCAWD 538


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  261 bits (666), Expect = 3e-69
 Identities = 153/406 (37%), Positives = 228/406 (56%), Gaps = 26/406 (6%)

Query: 70  LVVGARNYLFRLQLEDLSLIQAVE-----WECDEATKKACYSKGKSKEECQNYIRVLLVG 124
           L +  R+ ++ + L ++   + +      W   +  ++ C  KGK K+EC N+I+V +  
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128

Query: 125 GDRL-FTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAAT 183
            D + F CGTNAF P+C    LS L    ++ISG+ARCP+  +  + AL  A G+LY+AT
Sbjct: 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSAT 187

Query: 184 AMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DC 242
             DF   D  IYRS+G    LRT +Y+SKW+ EP+F+ + + GN+ YFFFRE AVEH + 
Sbjct: 188 VADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNL 247

Query: 243 GKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
           GK V+SR AR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + +++
Sbjct: 248 GKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQIN 307

Query: 302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHF 355
               + G+FTT +NSI  SAVC F++  I + F G FK Q+   S W   P    P P  
Sbjct: 308 GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

Query: 356 QCGTVDQGL------YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAV 407
            C     GL       ++  +  L   +   LM   V P+   P F +   R+  + ++V
Sbjct: 368 GC-CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISV 426

Query: 408 DVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLLEEIELF 451
           D   G      +I++ ++ G + KV    +  S   S LLEEIE +
Sbjct: 427 DHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAY 472


>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score =  253 bits (645), Expect = 9e-67
 Identities = 171/498 (34%), Positives = 257/498 (51%), Gaps = 33/498 (6%)

Query: 50  FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS---LIQAVEWECDEATKKACYS 106
           F  K   DF  L        L VGAR  +  L ++D     L   + W   +  K  C  
Sbjct: 56  FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAF 115

Query: 107 KGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSL--SNLTEIHDQ--ISGMAR 160
           K KS E +C N+IRVL+      L+TCGT AF+P CT   L  S L  I +   + G  +
Sbjct: 116 KKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQ 175

Query: 161 CPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLN-EPNF 219
            P+ P H  TA+L   G LY+ T  +F G +P + R+LG  P L+T  +  +WL+ + +F
Sbjct: 176 SPFDPAHKHTAVLV-DGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASF 233

Query: 220 VSSYDIGNFTYFFFRENAVEHDCGKTVF-SRAARVCKNDIGGRFLLEDTWTTFMKARLNC 278
           V++       YFFF E A E D  + +  SR ARVCKND+GG  LL+  WTTF+KA+L C
Sbjct: 234 VAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLC 293

Query: 279 SRPGEVPFYYNELQSTFFL----PELDLIYGIFTT--NVNSIAASAVCVFNLSAIAQAFS 332
           ++PG++PF  N ++    L    P    IY +FT+   V    +SAVC F+L  I + F 
Sbjct: 294 TQPGQLPF--NVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFK 351

Query: 333 GPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTV 392
           G +K      S W  Y  P  + + G+   G     +++ L   +   LM E    V   
Sbjct: 352 GKYKELNKETSRWTTYRGPETNPRPGSCSVG---PSSDKALTFMKDHFLMDE---QVVGT 405

Query: 393 PSFMEDNSRFSHVAVDVVQGREALVHII-YLATDYGTIKKVRVPLNQTSSSCLLEEIELF 451
           P  ++    ++ +AV+  QG +   H++ YL T  G++ K  V  +  SS+ L+EEI+LF
Sbjct: 406 PLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVV--SGDSSAHLVEEIQLF 463

Query: 452 PERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMK 511
           P+   EP+R+LQ+  +Q  +FVG    V ++P   C  Y +   C+ A+DP+C WD   +
Sbjct: 464 PD--PEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESR 521

Query: 512 KCTSLEESLSMTQWEQSI 529
            C  L  + ++  W+Q +
Sbjct: 522 TCCLL-SAPNLNSWKQDM 538


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score =  252 bits (644), Expect = 1e-66
 Identities = 177/525 (33%), Positives = 266/525 (50%), Gaps = 53/525 (10%)

Query: 38  ISYKEIGPW--LREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEW 94
           +S++E+  W  L+ F  +    +  L  D  +  L VGA N++  L L+++S   + + W
Sbjct: 33  LSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAW 92

Query: 95  ECDEATKKACYSKGKS-KEECQNYIRVL-LVGGDRLFTCGTNAFTPVCTNRSLSNLTE-- 150
                 ++ C   GK    EC N++++L       L  CGT AF P C    + +  E  
Sbjct: 93  PAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEP 152

Query: 151 --------IHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILP 202
                   I D   G  + PY P+H + ++L  G ELY+  A D  GRD  I+RSLG  P
Sbjct: 153 VLRLDPGRIED---GKGKSPYDPRHRAASVLV-GEELYSGVAADLMGRDFTIFRSLGQRP 208

Query: 203 PLRTAQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVE--HDCGKTVFSRAARV 253
            LRT  ++S+WLNEP FV  + I        +  YFFFRE AVE     G+   SR  ++
Sbjct: 209 SLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQI 268

Query: 254 CKNDIGGRFLLEDTWTTFMKARLNCSRPG-EVPFYYNELQSTFFLPELD----LIYGIFT 308
           C+ND+GG+  L + WTTF+KARL CS PG E   ++++LQ  F L   D    L+Y +F+
Sbjct: 269 CRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFS 328

Query: 309 TNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAW------LPYPNPN--PHFQCGTV 360
           T+ +    SAVCV++++ + +AF GPF ++E     W      +PYP P   P    GT 
Sbjct: 329 TSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTF 388

Query: 361 DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFME--DNSRFSHVAVDVVQGREALVH 418
                 +  +  +Q A+   LM+  V P    P F++   N  F+ +A D V   +    
Sbjct: 389 SS--TKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYD 446

Query: 419 IIYLATDYGTIKKV-RVPLNQTSSS--CLLEEIELFPERRREPIRSLQILHSQSVLFVGL 475
           ++++ TD GT+ KV  VP     S+   LLEE+ +F +     + S+QI   +  L+V  
Sbjct: 447 VLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED--SAAVTSMQISSKRHQLYVAS 504

Query: 476 REHVVKIPLKRCQFY-RTRSTCIGAQDPYCGWDVVMKKCTSLEES 519
           R  V +I L RC  + R  + C  A+DPYC WD V   CT  + S
Sbjct: 505 RSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGV--ACTRFQPS 547


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  251 bits (642), Expect = 2e-66
 Identities = 161/492 (32%), Positives = 249/492 (50%), Gaps = 47/492 (9%)

Query: 56  VDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKEEC 114
           +D   +  D  Q+ L VG R+ ++ L LE +S   + + W       + C  KGK   EC
Sbjct: 56  LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGEC 115

Query: 115 QNYIRVLL-VGGDRLFTCGTNAFTPVCT--------NRSLSNLTEIHDQISGMARCPYSP 165
            NY+RVL       L TCGT AF PVC            L +L     +  G  RCP+ P
Sbjct: 116 ANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRCPFDP 174

Query: 166 QHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDI 225
             +  + L  G EL+A    D+  RD AI+RS+G L  +RT   + + L EP FV SY I
Sbjct: 175 SSSFISTLI-GSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMI 233

Query: 226 -------GNFTYFFFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLN 277
                   N  YFFF E A+E  +    +++R  R+C ND+GG+ +L + W+TF+KARL 
Sbjct: 234 PDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLV 293

Query: 278 CSRPG--EVPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAF 331
           CS PG   +  Y++EL+  F LP  D    +I+G+F T  N     A+CV+++S+I  AF
Sbjct: 294 CSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAF 353

Query: 332 SGPFKYQENSRSAW------LPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFI----L 381
           +GP+ ++E     W      +PYP P     C +   G     T+    DA +F     L
Sbjct: 354 NGPYAHKEGPEYHWSVYEGKVPYPRPG---SCASKVNGGRYGTTKDYPDDAIRFARSHPL 410

Query: 382 MHEVVQPVTTVPSFMEDNSRFS--HVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQT 439
           M++ ++P    P  ++ + +++   +AVD V+  +    ++++ TD G + KV    NQ 
Sbjct: 411 MYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQE 470

Query: 440 SSS---CLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTR-ST 495
             S    +LEE+++F +    PI S++I   +  L++G    V ++    C  Y +  + 
Sbjct: 471 MESMEEVILEELQIFKD--PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACAD 528

Query: 496 CIGAQDPYCGWD 507
           C  A+DPYC WD
Sbjct: 529 CCLARDPYCAWD 540


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  249 bits (637), Expect = 8e-66
 Identities = 164/489 (33%), Positives = 256/489 (52%), Gaps = 42/489 (8%)

Query: 56  VDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKEE- 113
           +D+  L  D  Q  + VG+++++  L + ++S    +V W       + C   GK     
Sbjct: 52  LDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHG 111

Query: 114 CQNYIRVLLV-GGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQI--------SGMARCPYS 164
           C N++RV+       L+ CG+ AF+PVCT  +    +E  DQ+        SG  RC ++
Sbjct: 112 CGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSE--DQVFMIDSKCESGKGRCSFN 169

Query: 165 PQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYD 224
           P  N+ +++    EL++   +DF G D AI+RSL     +RT Q+NSKWL+EP FV ++ 
Sbjct: 170 PNVNTVSVMI-NEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHV 228

Query: 225 IGNFT-------YFFFRENAVEHDCG-KTVFSRAARVCKNDIGGRFLLEDTWTTFMKARL 276
           I + T       YFFF+E   +++   K + S  AR+C ND GG   L + WTTF+KARL
Sbjct: 229 IPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARL 288

Query: 277 NCSRPGE--VPFYYNELQSTFFL----PELDLIYGIFTTNVNSIAASAVCVFNLSAIAQA 330
            CS   E     +++EL+  F L    P   L+YGIFTT+ +    SAVCV++LS I   
Sbjct: 289 VCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTV 348

Query: 331 FSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLY---VNLTERNLQDAQKFI----LMH 383
           F+GPF ++E      + Y    P+ + GT   G +   +  T+    D   FI    LM+
Sbjct: 349 FNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMY 408

Query: 384 EVVQPVTTVPSFME--DNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRV--PLNQT 439
             + P+   P  +    + +++ +AVD V   +   H+++L TD GT++KV V    N  
Sbjct: 409 NSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSV 468

Query: 440 SSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTR-STCIG 498
           S   +LEE+E+F  +   PI +++I   +  L+V   E V ++ L RC  Y T  + C  
Sbjct: 469 SGELILEELEVF--KNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCL 526

Query: 499 AQDPYCGWD 507
           A+DPYC WD
Sbjct: 527 ARDPYCAWD 535


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  249 bits (635), Expect = 1e-65
 Identities = 180/569 (31%), Positives = 285/569 (50%), Gaps = 63/569 (11%)

Query: 36  PVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQ-AVEW 94
           P I+++     L +F   +  ++S L     +  L +GAR  +F +   ++S  Q  V W
Sbjct: 28  PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYW 87

Query: 95  ECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIH 152
           +  E  K  C  KGKSK+ EC NYIRVL  +    L+ CGTNAF P C + +L++   + 
Sbjct: 88  KVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLG 147

Query: 153 DQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSK 212
               G  RCP+ P H+ T+++   GELY+ T+ +F G +P I R+     PLRT +Y   
Sbjct: 148 KNEDGKGRCPFDPAHSYTSVMV-DGELYSGTSYNFLGSEPIISRNSSH-SPLRT-EYAIP 204

Query: 213 WLNEPNFVSSYDI----------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGR 261
           WLNEP+FV +  I           +  YFFF E +VE++   + +  R ARVCK D GG 
Sbjct: 205 WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL 264

Query: 262 FLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLP----ELDLIYGIFTTNVNSIAAS 317
             L+  WT+F+KARL CSRP +    +N L+  F L     ++ + Y +FT  +N++  S
Sbjct: 265 RTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLS 323

Query: 318 AVCVFNLSAIAQAFSGPFKYQ-----ENSRSAWL----PYPNPNP----HFQCGTVDQGL 364
           AVC +NLS   + FS   KY      E S + W+    P P P P      +    +   
Sbjct: 324 AVCAYNLSTAEEVFSHG-KYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382

Query: 365 YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLA 423
            +NL ++ LQ  +   LM + V P+   P  ++ +  ++ + VD  Q  +  V+ +++++
Sbjct: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442

Query: 424 TDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFV--GLREHVVK 481
           TD G + K    ++   +  ++EE +LF +   EP+++L +   +   FV  G    VV+
Sbjct: 443 TDRGALHKA---ISLEHAVHIIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNSGVVQ 497

Query: 482 IPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLS-----MTQWEQSISACP--- 533
            PL  C  + T   C+ A+DPYC W      C +L ++ S     + +     S CP   
Sbjct: 498 APLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASS 557

Query: 534 --------TRNLTVDGHFG---VWSPWTP 551
                   + +L+  GH G   + SPWTP
Sbjct: 558 PKPLPPPGSSSLSCLGHVGDRRLSSPWTP 586


>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score =  248 bits (634), Expect = 2e-65
 Identities = 177/525 (33%), Positives = 266/525 (50%), Gaps = 54/525 (10%)

Query: 38  ISYKEIGPW--LREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEW 94
           +S++E+  W  L+ F  +    +  L  D  +  L VGA N++  L L+++S   + + W
Sbjct: 33  LSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAW 92

Query: 95  ECDEATKKACYSKGKS-KEECQNYIRVL-LVGGDRLFTCGTNAFTPVCTNRSLSNLTE-- 150
                 ++ C   GK    EC N++++L       L  CGT AF P C    + +  E  
Sbjct: 93  PAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEP 152

Query: 151 --------IHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILP 202
                   I D   G  + PY P+H + ++L  G ELY+  A D  GRD  I+RSLG  P
Sbjct: 153 VLRLDPGRIED---GKGKSPYDPRHRAASVLV-GEELYSGVAADLMGRDFTIFRSLGQRP 208

Query: 203 PLRTAQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVE--HDCGKTVFSRAARV 253
            LRT  ++S+WLNEP FV  + I        +  YFFFRE AVE     G+   SR  ++
Sbjct: 209 SLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQI 268

Query: 254 CKNDIGGRFLLEDTWTTFMKARLNCSRPG-EVPFYYNELQSTFFLPELD----LIYGIFT 308
           C+ND+GG+  L + WTTF+KARL CS PG E   ++++LQ  F L   D    L+Y +F+
Sbjct: 269 CRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFS 328

Query: 309 TNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAW------LPYPNPN--PHFQCGTV 360
           T+ +    SAVCV++++ + +AF GPF ++E     W      +PYP P   P    GT 
Sbjct: 329 TS-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTF 387

Query: 361 DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFME--DNSRFSHVAVDVVQGREALVH 418
                 +  +  +Q A+   LM+  V P    P F++   N  F+ +A D V   +    
Sbjct: 388 SS--TKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYD 445

Query: 419 IIYLATDYGTIKKV-RVPLNQTSSS--CLLEEIELFPERRREPIRSLQILHSQSVLFVGL 475
           ++++ TD GT+ KV  VP     S+   LLEE+ +F +     + S+QI   +  L+V  
Sbjct: 446 VLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED--SAAVTSMQISSKRHQLYVAS 503

Query: 476 REHVVKIPLKRCQFY-RTRSTCIGAQDPYCGWDVVMKKCTSLEES 519
           R  V +I L RC  + R  + C  A+DPYC WD V   CT  + S
Sbjct: 504 RSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGV--ACTRFQPS 546


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  248 bits (632), Expect = 3e-65
 Identities = 166/496 (33%), Positives = 255/496 (51%), Gaps = 44/496 (8%)

Query: 52  AKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGK- 109
           +   +DF  L  D  +  L++GA++++F L L DL+   + + W   +   + C   GK 
Sbjct: 64  SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKD 123

Query: 110 SKEECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTE-------IHDQISGMARC 161
           +  EC N+IRVL       ++ CGT AF P+C    L    E        H+  SG  +C
Sbjct: 124 ANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKC 183

Query: 162 PYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPP---LRTAQYNSKWLNEPN 218
           P+ PQ    +++T    LY+ TA DF G+D A  RSLG       +RT      WLN   
Sbjct: 184 PFDPQQPFASVMT-DEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAK 242

Query: 219 FVSSYDIGNF-------TYFFFRENAVEHDCG-KTVFSRAARVCKNDIGGRFLLEDTWTT 270
           F+ ++ I +         YFFFRE++ E     KT+ SR  RVCKND+GG+  L + WTT
Sbjct: 243 FIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTT 302

Query: 271 FMKARLNCSRPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNL 324
           F+KARL CS PG      Y++ELQ  + LP  D    ++YG+FTT  +    SAVCV+++
Sbjct: 303 FLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSM 362

Query: 325 SAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLY---VNLTERNLQDAQKFIL 381
           + I   F+GP+ ++E++   W+ Y    P+ + GT     Y   +  T     D   FI 
Sbjct: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIK 422

Query: 382 MHEV----VQPVTTVPSFMEDN--SRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVP 435
            H V    V PV   P+F   N   R + + VD V   +    +++L TD GT+ KV V 
Sbjct: 423 RHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKV-VS 481

Query: 436 LNQ---TSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFY-R 491
           +++        +LEE+++F  +    I ++++   Q  L++G R+ +V++ L RC  Y +
Sbjct: 482 ISKEKWNMEEVVLEELQIF--KHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGK 539

Query: 492 TRSTCIGAQDPYCGWD 507
             + C  A+DPYC WD
Sbjct: 540 ACADCCLARDPYCAWD 555


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  243 bits (621), Expect = 5e-64
 Identities = 171/540 (31%), Positives = 274/540 (50%), Gaps = 49/540 (9%)

Query: 36  PVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQ-AVEW 94
           P I+++     L +F   +  ++S L     +  L +GAR  +F +   ++S  Q  V W
Sbjct: 28  PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYW 87

Query: 95  ECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIH 152
           +  E  K  C  KGKSK+ EC NYIRVL  +    L+ CGTNAF P C + +L++   + 
Sbjct: 88  KVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLG 147

Query: 153 DQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSK 212
               G  RCP+ P H+ T+++   GELY+ T+ +F G +P I R+     PLRT +Y   
Sbjct: 148 KNEDGKGRCPFDPAHSYTSVMV-DGELYSGTSYNFLGSEPIISRNSSH-SPLRT-EYAIP 204

Query: 213 WLNEPNFVSSYDI----------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGR 261
           WLNEP+FV +  I           +  YFFF E +VE++   + +  R ARVCK D GG 
Sbjct: 205 WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL 264

Query: 262 FLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLP----ELDLIYGIFTTNVNSIAAS 317
             L+  WT+F+KARL CSRP +    +N L+  F L     ++ + Y +FT  +N++  S
Sbjct: 265 RTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLS 323

Query: 318 AVCVFNLSAIAQAFSGPFKYQ-----ENSRSAWL----PYPNPNP----HFQCGTVDQGL 364
           AVC +NLS   + FS   KY      E S + W+    P P P P      +    +   
Sbjct: 324 AVCAYNLSTAEEVFSHG-KYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382

Query: 365 YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLA 423
            +NL ++ LQ  +   LM + V P+   P  ++ +  ++ + VD  Q  +  V+ +++++
Sbjct: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442

Query: 424 TDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFV--GLREHVVK 481
           TD G + K    ++   +  ++EE +LF +   EP+++L +   +   FV  G    VV+
Sbjct: 443 TDRGALHKA---ISLEHAVHIIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNSGVVQ 497

Query: 482 IPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLS-----MTQWEQSISACPTRN 536
            PL  C  + T   C+ A+DPYC W      C +L ++ S     + +     S CP ++
Sbjct: 498 APLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKS 557


>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  240 bits (612), Expect = 6e-63
 Identities = 171/531 (32%), Positives = 259/531 (48%), Gaps = 49/531 (9%)

Query: 45  PWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI-----QAVEWECDEA 99
           P+LR F A++  +++ L      + L VGAR  LF L   +LS +     Q + W  D  
Sbjct: 58  PFLR-FEAEHISNYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAE 115

Query: 100 TKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQIS- 156
            K+ C  KGK  + +CQNYI++LL + G  LFTCGT AF+P+CT  ++ N T   D+   
Sbjct: 116 KKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGN 175

Query: 157 -----GMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNS 211
                G  RCP+ P   STAL+   GELY  T   F G DPAI RS  + P    +  N 
Sbjct: 176 VLLEDGKGRCPFDPNFKSTALVV-DGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN- 233

Query: 212 KWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDCGK-TVFSRAARVCKNDIGG 260
            WL +P FV+S  I           +  YFFF E   E +  + T+ SR AR+CK D GG
Sbjct: 234 -WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG 292

Query: 261 RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL------DLIYGIFTT--NVN 312
             +L+  WT+F+KA+L CSRP +  F +N LQ  F L          L YG+FT+  +  
Sbjct: 293 ERVLQQRWTSFLKAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRG 351

Query: 313 SIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWL----PYPNPNPHFQCGTVDQGLYVNL 368
           +   SAVCVF +  + + FSG +K        W     P P P P        +   +N 
Sbjct: 352 TTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINS 411

Query: 369 TERNLQDAQKFILMHEVVQ-PVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYG 427
           + +       F+  H ++   V +    ++  +R+  VAV  V G      +++L T  G
Sbjct: 412 SLQLPDRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDG 471

Query: 428 TIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
            + K    ++      ++EE+++F     +P+++L +   + +L+      VV++P+  C
Sbjct: 472 RLHKA---VSVGPRVHIIEELQIFSS--GQPVQNLLLDTHRGLLYAASHSGVVQVPMANC 526

Query: 488 QFYRTRSTCIGAQDPYCGWDVVMKKCTSL-EESLSMTQWEQSISACPTRNL 537
             YR+   C+ A+DPYC W     K  SL +  L+   W Q I     ++L
Sbjct: 527 SLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  240 bits (612), Expect = 6e-63
 Identities = 171/531 (32%), Positives = 259/531 (48%), Gaps = 49/531 (9%)

Query: 45  PWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI-----QAVEWECDEA 99
           P+LR F A++  +++ L      + L VGAR  LF L   +LS +     Q + W  D  
Sbjct: 58  PFLR-FEAEHISNYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAE 115

Query: 100 TKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQIS- 156
            K+ C  KGK  + +CQNYI++LL + G  LFTCGT AF+P+CT  ++ N T   D+   
Sbjct: 116 KKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGN 175

Query: 157 -----GMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNS 211
                G  RCP+ P   STAL+   GELY  T   F G DPAI RS  + P    +  N 
Sbjct: 176 VLLEDGKGRCPFDPNFKSTALVV-DGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN- 233

Query: 212 KWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDCGK-TVFSRAARVCKNDIGG 260
            WL +P FV+S  I           +  YFFF E   E +  + T+ SR AR+CK D GG
Sbjct: 234 -WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGG 292

Query: 261 RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL------DLIYGIFTT--NVN 312
             +L+  WT+F+KA+L CSRP +  F +N LQ  F L          L YG+FT+  +  
Sbjct: 293 ERVLQQRWTSFLKAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRG 351

Query: 313 SIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWL----PYPNPNPHFQCGTVDQGLYVNL 368
           +   SAVCVF +  + + FSG +K        W     P P P P        +   +N 
Sbjct: 352 TTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINS 411

Query: 369 TERNLQDAQKFILMHEVVQ-PVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYG 427
           + +       F+  H ++   V +    ++  +R+  VAV  V G      +++L T  G
Sbjct: 412 SLQLPDRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDG 471

Query: 428 TIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
            + K    ++      ++EE+++F     +P+++L +   + +L+      VV++P+  C
Sbjct: 472 RLHKA---VSVGPRVHIIEELQIFSS--GQPVQNLLLDTHRGLLYAASHSGVVQVPMANC 526

Query: 488 QFYRTRSTCIGAQDPYCGWDVVMKKCTSL-EESLSMTQWEQSISACPTRNL 537
             YR+   C+ A+DPYC W     K  SL +  L+   W Q I     ++L
Sbjct: 527 SLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  238 bits (606), Expect = 3e-62
 Identities = 160/520 (30%), Positives = 252/520 (48%), Gaps = 69/520 (13%)

Query: 54  NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAV-EWECDEATKKACYSKGKSKE 112
           N  D+  L  D     + VG+++Y+  L L D++    +  W       + C   GK   
Sbjct: 53  NTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVN 112

Query: 113 -ECQNYIRVLLVGG-DRLFTCGTNAFTPVCT--NRSL-----------------SNLTE- 150
            EC N++R++       L+ CGT A+ P+CT  NR                   S  T+ 
Sbjct: 113 GECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDG 172

Query: 151 ---------IHDQI---------SGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDP 192
                      D I         SG  +CPY P+ ++ + L    ELYA   +DF G D 
Sbjct: 173 ALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALI-NEELYAGVYIDFMGTDA 231

Query: 193 AIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFT-------YFFFRENAVEHDCGKT 245
           AI+R+LG    +RT QYNS+WLN+P+F+ +  I +         YFFFRE + E      
Sbjct: 232 AIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPA 291

Query: 246 VFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGE--VPFYYNELQSTFFLPELD-- 301
           V++R  R+C ND GG   L + W+TF+KARL CS PGE  +  +++ELQ  F     D  
Sbjct: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351

Query: 302 --LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGT 359
             +IY +FT++ +    SAVCV++++ I   F+GPF ++E     W+P+    P+ + GT
Sbjct: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGT 411

Query: 360 VDQGLYV-------NLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNS--RFSHVAVDVV 410
              G +        +  +  +   +   LM++ V P+   P  +   +  R + +AVD V
Sbjct: 412 CPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQV 471

Query: 411 QGREALVHIIYLATDYGTIKKVRV--PLNQTSSSCLLEEIELFPERRREPIRSLQILHSQ 468
              +    +++L TD GT++KV V    +Q     +LEE+E+F +    P++++ I   +
Sbjct: 472 DAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKD--PAPVKTMTISSKR 529

Query: 469 SVLFVGLREHVVKIPLKRCQFYRTR-STCIGAQDPYCGWD 507
             L+V     V  + L RCQ Y    + C  A+DPYC WD
Sbjct: 530 QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD 569


>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score =  212 bits (539), Expect = 2e-54
 Identities = 162/516 (31%), Positives = 245/516 (47%), Gaps = 48/516 (9%)

Query: 32  RTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLE-DLSLIQ 90
           RT  P+    E    L  F   +  ++S L  DP    L VGAR+ +F L L       +
Sbjct: 42  RTSLPI---SEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPR 98

Query: 91  AVEWECDEATKKACYSKGKSKEECQNYIRVLLVGG-DRLFTCGTNAFTPVCTNRSLSNLT 149
            ++W   EA ++ C  KGK ++EC N++++L +     L TCGT AF P C    +S   
Sbjct: 99  RIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQ 158

Query: 150 EIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
           ++    SG  +CP+ P   S A++ AGG LYAAT  ++ G +P I R++G          
Sbjct: 159 QVERLESGRGKCPFEPAQRSAAVM-AGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDT 217

Query: 210 NSKWLNEPNFVSSY----------DIGNFTYFFFRENAVEHDCGKTV-FSRAARVCKNDI 258
              WLN P FV++           D  +  YFFF E +   D  + +   R ARVC  D+
Sbjct: 218 LPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDL 277

Query: 259 GGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFL-PEL----DLIYGIFTTNVNS 313
           GGR  L+  WTTF+KA L C  P E     + LQ    L PEL     + YGIF++    
Sbjct: 278 GGRKTLQQRWTTFLKADLLCPGP-EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEG 336

Query: 314 IAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP-----YPNPNPHFQCGTVDQ-----G 363
              SAVC F    I    +GPF+  ++  +  LP      P P P  +C T +      G
Sbjct: 337 ATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPG-ECITNNMKLRHFG 395

Query: 364 LYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVA---VDVVQGREALVHII 420
             ++L +R L   +   LM   V P    P  +  ++ +  V    V  + G+E    ++
Sbjct: 396 SSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKE--YDVL 453

Query: 421 YLATDYGTI-KKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHV 479
           YL T+ G + + VR+     +   +LE++ LFPE   +P+ ++++ HS   L VG R  V
Sbjct: 454 YLGTEDGHLHRAVRI----GAQLSVLEDLALFPE--PQPVENMKLYHSW--LLVGSRTEV 505

Query: 480 VKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTS 515
            ++    C   ++ S CI AQDP C W   + +C +
Sbjct: 506 TQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVA 541


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  197 bits (501), Expect = 4e-50
 Identities = 162/519 (31%), Positives = 234/519 (45%), Gaps = 51/519 (9%)

Query: 33  TEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS--LIQ 90
           T    I Y+E+    R F+ + A ++S L  +     L+VGAR  LF L   D+     +
Sbjct: 33  TPRMTIPYEELSG-TRHFKGQ-AQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHK 90

Query: 91  AVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNL 148
            + WE     +  C+ KGK+ + EC N++R L  +    L+ CGT+AF P+C        
Sbjct: 91  EIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAF 150

Query: 149 TEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQ 208
           T       G  +CPY P    T L+  GG LY AT  +F    P I RS      LRT +
Sbjct: 151 TLPTSFEEGKEKCPYDPARGFTGLIIDGG-LYTATRYEFRSI-PDIRRSRHP-HSLRTEE 207

Query: 209 YNSKWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDCGKTVFSRA-------A 251
               WLN+  FV S  +           +  Y+FF E A E   G    SR+       A
Sbjct: 208 TPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVA 267

Query: 252 RVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLP----ELDLIYGIF 307
           RVCK D+GG+ +L+  WT+F+KARL C  P      Y  L+    L          Y  F
Sbjct: 268 RVCKGDLGGKKILQKKWTSFLKARLICHIP-----LYETLRGVCSLDAETSSRTHFYAAF 322

Query: 308 T--TNVNSIAASAVCVFNLSAIAQAFSGPF-KYQENSR-----SAWLPYPNPNPHFQCGT 359
           T  T   ++ ASA+C ++L+ I   F+GP+ +YQ+ SR        +P P P        
Sbjct: 323 TLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSL 382

Query: 360 VDQGLYVN--LTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVA-VDVVQGREAL 416
             QG   +  L    L   +   LM   V P    P  ++ N R++H+    V       
Sbjct: 383 RSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPT 442

Query: 417 VHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLR 476
             +++L T  G I K  V     S   ++EE ++F  R  + + +L I   Q  L+VG  
Sbjct: 443 YDLLFLGTADGWIHKAVV---LGSGMHIIEETQVF--RESQSVENLVISLLQHSLYVGAP 497

Query: 477 EHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTS 515
             V+++PL  C  YR+   CI A+DPYCGWD     C +
Sbjct: 498 SGVIQLPLSSCSRYRSCYDCILARDPYCGWDPGTHACAA 536


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  191 bits (484), Expect = 4e-48
 Identities = 162/565 (28%), Positives = 260/565 (46%), Gaps = 55/565 (9%)

Query: 7   IAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLRE---FRAKNAVDFSQLTF 63
           I WL   L    L H  + G +         +SY+++    R       + +++   +  
Sbjct: 8   ICWLLGGL----LLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYL 63

Query: 64  DPGQKELVVGARNYLFRLQLEDL-SLIQAVEWECDEATKKACYSKGKSK-EECQNYIRVL 121
           D  +  L +G  + L+ L+L+      + V W      ++ C  KG+    EC N++RVL
Sbjct: 64  DEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVL 123

Query: 122 LVGG-DRLFTCGTNAFTPVCTNRSLSNLTE--IHDQI----SGMARCPYSPQHNSTALLT 174
                  L  CGT AF P C   ++ +  E  +H +     SG  RCP+ P     +   
Sbjct: 124 QPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFI 183

Query: 175 AGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDI-------GN 227
             GELY     DF GR+  I+RS G  P LR+    S  L++P FV +  I        +
Sbjct: 184 -DGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAARIPENSDQDND 241

Query: 228 FTYFFFRENAVEHDCGKT--VFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCS--RPGE 283
             YFFF E     D G      SR  RVC ND GG+ +L + W+TF+KARL CS   PG 
Sbjct: 242 KVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGG 301

Query: 284 VPFYYNELQSTFFL-PELDL---IYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQE 339
              ++++L+  F L P+      +Y +F+T        AVCV++++ I + F+GPF +++
Sbjct: 302 AETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRD 361

Query: 340 NSRSAWLPYPNPNPHFQCGTVDQ----------GLYVNLTERNLQDAQKFILMHEVVQPV 389
             +  W PY    P  + G              G   +  +  LQ A+   LM   V+P 
Sbjct: 362 GPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPR 421

Query: 390 TTVPSFMEDN--SRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSS----C 443
              P  ++ +   +   + VD V+  +    +I+L TD G++ KV + L    S+     
Sbjct: 422 HGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKV-IALQAGGSAEPEEV 480

Query: 444 LLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTR-STCIGAQDP 502
           +LEE+++F  +   PI  ++I   + +L+VG R  V ++ L +C+ Y T  + C  A+DP
Sbjct: 481 VLEELQVF--KVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDP 538

Query: 503 YCGWDVVMKKCTSLEESLSMTQWEQ 527
           YC WD     CT    SL   ++ +
Sbjct: 539 YCAWDGA--SCTHYRPSLGKRRFRR 561


>gi|4505737 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score =  183 bits (465), Expect = 7e-46
 Identities = 113/355 (31%), Positives = 153/355 (43%), Gaps = 41/355 (11%)

Query: 594 RNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQ-NREERYCNEHLLCPP 652
           R+  W+ W++W+PCS TC  G Q+R R C     +  G+V  G    + + C +   CP 
Sbjct: 76  RSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPE 135

Query: 653 HMFWTGWGPWERCTAQCGGGIQARRRICEN-----GPDCAGCNVEYQSCNTNP-CPELKK 706
              W+GWGPWE C+  C  G + RRR C +     G  C G   E ++C+T   CP    
Sbjct: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGA 195

Query: 707 TTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTD 766
              W PWTP + S +GG +E +   + K    +P                S    G    
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEP----------------SQKPPGKPCP 239

Query: 767 GLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGP 826
           GL+ +  R        V G W  W   S C   C  G    +R CN+P P++GG  C G 
Sbjct: 240 GLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGD 299

Query: 827 SLEYQECN-ILPCPVDGVWSCWSPWTKC------SATCG--GGHYMRTRSCSNPAPAYGG 877
           +     CN  +PCPVDG W  W  W+ C      S +C    G   R R+C      + G
Sbjct: 300 ATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCR--GRKFDG 357

Query: 878 DICLGLHTEEALC-NTQPCP--ESWSEWSDWS----ECEASGVQVRARQCILLFP 925
             C G   +   C + Q CP   SWSEWS W      C  +  + R R C  L P
Sbjct: 358 HRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLP 412



 Score =  160 bits (404), Expect = 8e-39
 Identities = 113/366 (30%), Positives = 152/366 (41%), Gaps = 64/366 (17%)

Query: 543 FGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGG--------WQCEGPGMEIANCSR 594
           + +WS W PC+ T   + GS L R R C     QC G        WQ +    +   C  
Sbjct: 80  WSLWSTWAPCSVT--CSEGSQL-RYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC-CPE 135

Query: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM 654
            GGW+ W  W PCS TC  G + R+R+C++P P+ GG  C GQ +E   C+   +CP H 
Sbjct: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHG 194

Query: 655 FWTGWGPWERCTAQCGGG----IQARRRICE--------NGPDCAGCNVEYQSC-NTNPC 701
            W  WGPW  C+A C GG     + R R C          G  C G   E + C    PC
Sbjct: 195 AWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPC 254

Query: 702 PELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTS 761
           P      PW P +P  ++   G        T + R  +  + + G       +C+ D T 
Sbjct: 255 PVAGGWGPWGPVSPCPVTCGLGQ-------TMEQRTCNHPVPQHGGP-----FCAGDATR 302

Query: 762 G--CSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSR------DCSR--GIRNRKRVC 811
              C+T                 V+G W +W  WS C R       C    G ++R R C
Sbjct: 303 THICNT------------AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC 350

Query: 812 NNPEPKYGGMPCLGPSLEYQEC-NILPCPVDGVWSCWSPWTKCSATCG-GGHYMRTRSCS 869
                K+ G  C G   + + C +I  CP+ G WS WS W  C   CG      R R C+
Sbjct: 351 RG--RKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408

Query: 870 NPAPAY 875
              P Y
Sbjct: 409 PLLPKY 414



 Score =  147 bits (370), Expect = 7e-35
 Identities = 97/316 (30%), Positives = 127/316 (40%), Gaps = 56/316 (17%)

Query: 656 WTGWGPWERCTAQCGGGIQARRRICE--NGPDCAG------CNVEYQSCNTNPC-PELKK 706
           W+ W  W  C+  C  G Q R R C   NG  C+G         + Q+C    C PE+  
Sbjct: 80  WSLWSTWAPCSVTCSEGSQLRYRRCVGWNG-QCSGKVAPGTLEWQLQACEDQQCCPEMGG 138

Query: 707 TTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTS-GCST 765
            + W PW P +++ + G                         R   R C+      G   
Sbjct: 139 WSGWGPWEPCSVTCSKG------------------------TRTRRRACNHPAPKCGGHC 174

Query: 766 DGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRN----RKRVCNNPEP--KYG 819
            G + +            +GAW+ W  W+ CS  C  G       R R C+ PEP  K  
Sbjct: 175 PGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPP 234

Query: 820 GMPCLGPSLEYQECNILP-CPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGD 878
           G PC G + E + C  LP CPV G W  W P + C  TCG G  M  R+C++P P +GG 
Sbjct: 235 GKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGP 294

Query: 879 ICLGLHTEEALCNTQ-PCP--ESWSEWSDWSEC-----------EASGVQVRARQCILLF 924
            C G  T   +CNT  PCP    W  W +WS C           E  G Q R R C    
Sbjct: 295 FCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK 354

Query: 925 PMGSQCSGNTTESRPC 940
             G +C+G   + R C
Sbjct: 355 FDGHRCAGQQQDIRHC 370



 Score =  135 bits (340), Expect = 2e-31
 Identities = 91/314 (28%), Positives = 122/314 (38%), Gaps = 41/314 (13%)

Query: 526 EQSISACPTRNLTVD-GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEG 584
           E  + AC  +    + G +  W PW PC+ T      +   R R+C+ PAP+CGG  C G
Sbjct: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRT---RRRACNHPAPKCGG-HCPG 176

Query: 585 PGMEIANCS------RNGGWTPWTSWSPCSTTCGIG----FQVRQRSCSNPTP--RHGGR 632
              E   C        +G W  W  W+PCS +C  G     + R R CS P P  +  G+
Sbjct: 177 QAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGK 236

Query: 633 VCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN------GPDC 686
            C G   E+R C     CP    W  WGP   C   CG G    +R C +      GP C
Sbjct: 237 PCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296

Query: 687 AGCNVEYQSCNTN-PCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEV 745
           AG       CNT  PCP   +   W  W+P                  +  +   +  E+
Sbjct: 297 AGDATRTHICNTAVPCPVDGEWDSWGEWSP----------------CIRRNMKSISCQEI 340

Query: 746 GRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCS-RGI 804
             Q+   R C      G    G   D           + G+WS W++W  C   C     
Sbjct: 341 PGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPT 400

Query: 805 RNRKRVCNNPEPKY 818
           R R+R+C    PKY
Sbjct: 401 RARQRLCTPLLPKY 414


>gi|223671861 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score =  183 bits (465), Expect = 7e-46
 Identities = 113/355 (31%), Positives = 153/355 (43%), Gaps = 41/355 (11%)

Query: 594 RNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQ-NREERYCNEHLLCPP 652
           R+  W+ W++W+PCS TC  G Q+R R C     +  G+V  G    + + C +   CP 
Sbjct: 76  RSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPE 135

Query: 653 HMFWTGWGPWERCTAQCGGGIQARRRICEN-----GPDCAGCNVEYQSCNTNP-CPELKK 706
              W+GWGPWE C+  C  G + RRR C +     G  C G   E ++C+T   CP    
Sbjct: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGA 195

Query: 707 TTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTD 766
              W PWTP + S +GG +E +   + K    +P                S    G    
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEP----------------SQKPPGKPCP 239

Query: 767 GLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGP 826
           GL+ +  R        V G W  W   S C   C  G    +R CN+P P++GG  C G 
Sbjct: 240 GLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGD 299

Query: 827 SLEYQECN-ILPCPVDGVWSCWSPWTKC------SATCG--GGHYMRTRSCSNPAPAYGG 877
           +     CN  +PCPVDG W  W  W+ C      S +C    G   R R+C      + G
Sbjct: 300 ATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCR--GRKFDG 357

Query: 878 DICLGLHTEEALC-NTQPCP--ESWSEWSDWS----ECEASGVQVRARQCILLFP 925
             C G   +   C + Q CP   SWSEWS W      C  +  + R R C  L P
Sbjct: 358 HRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLP 412



 Score =  160 bits (404), Expect = 8e-39
 Identities = 113/366 (30%), Positives = 152/366 (41%), Gaps = 64/366 (17%)

Query: 543 FGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGG--------WQCEGPGMEIANCSR 594
           + +WS W PC+ T   + GS L R R C     QC G        WQ +    +   C  
Sbjct: 80  WSLWSTWAPCSVT--CSEGSQL-RYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC-CPE 135

Query: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM 654
            GGW+ W  W PCS TC  G + R+R+C++P P+ GG  C GQ +E   C+   +CP H 
Sbjct: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHG 194

Query: 655 FWTGWGPWERCTAQCGGG----IQARRRICE--------NGPDCAGCNVEYQSC-NTNPC 701
            W  WGPW  C+A C GG     + R R C          G  C G   E + C    PC
Sbjct: 195 AWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPC 254

Query: 702 PELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTS 761
           P      PW P +P  ++   G        T + R  +  + + G       +C+ D T 
Sbjct: 255 PVAGGWGPWGPVSPCPVTCGLGQ-------TMEQRTCNHPVPQHGGP-----FCAGDATR 302

Query: 762 G--CSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSR------DCSR--GIRNRKRVC 811
              C+T                 V+G W +W  WS C R       C    G ++R R C
Sbjct: 303 THICNT------------AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC 350

Query: 812 NNPEPKYGGMPCLGPSLEYQEC-NILPCPVDGVWSCWSPWTKCSATCG-GGHYMRTRSCS 869
                K+ G  C G   + + C +I  CP+ G WS WS W  C   CG      R R C+
Sbjct: 351 RG--RKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408

Query: 870 NPAPAY 875
              P Y
Sbjct: 409 PLLPKY 414



 Score =  147 bits (370), Expect = 7e-35
 Identities = 97/316 (30%), Positives = 127/316 (40%), Gaps = 56/316 (17%)

Query: 656 WTGWGPWERCTAQCGGGIQARRRICE--NGPDCAG------CNVEYQSCNTNPC-PELKK 706
           W+ W  W  C+  C  G Q R R C   NG  C+G         + Q+C    C PE+  
Sbjct: 80  WSLWSTWAPCSVTCSEGSQLRYRRCVGWNG-QCSGKVAPGTLEWQLQACEDQQCCPEMGG 138

Query: 707 TTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTS-GCST 765
            + W PW P +++ + G                         R   R C+      G   
Sbjct: 139 WSGWGPWEPCSVTCSKG------------------------TRTRRRACNHPAPKCGGHC 174

Query: 766 DGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRN----RKRVCNNPEP--KYG 819
            G + +            +GAW+ W  W+ CS  C  G       R R C+ PEP  K  
Sbjct: 175 PGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPP 234

Query: 820 GMPCLGPSLEYQECNILP-CPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGD 878
           G PC G + E + C  LP CPV G W  W P + C  TCG G  M  R+C++P P +GG 
Sbjct: 235 GKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGP 294

Query: 879 ICLGLHTEEALCNTQ-PCP--ESWSEWSDWSEC-----------EASGVQVRARQCILLF 924
            C G  T   +CNT  PCP    W  W +WS C           E  G Q R R C    
Sbjct: 295 FCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK 354

Query: 925 PMGSQCSGNTTESRPC 940
             G +C+G   + R C
Sbjct: 355 FDGHRCAGQQQDIRHC 370



 Score =  135 bits (340), Expect = 2e-31
 Identities = 91/314 (28%), Positives = 122/314 (38%), Gaps = 41/314 (13%)

Query: 526 EQSISACPTRNLTVD-GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEG 584
           E  + AC  +    + G +  W PW PC+ T      +   R R+C+ PAP+CGG  C G
Sbjct: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRT---RRRACNHPAPKCGG-HCPG 176

Query: 585 PGMEIANCS------RNGGWTPWTSWSPCSTTCGIG----FQVRQRSCSNPTP--RHGGR 632
              E   C        +G W  W  W+PCS +C  G     + R R CS P P  +  G+
Sbjct: 177 QAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGK 236

Query: 633 VCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN------GPDC 686
            C G   E+R C     CP    W  WGP   C   CG G    +R C +      GP C
Sbjct: 237 PCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296

Query: 687 AGCNVEYQSCNTN-PCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEV 745
           AG       CNT  PCP   +   W  W+P                  +  +   +  E+
Sbjct: 297 AGDATRTHICNTAVPCPVDGEWDSWGEWSP----------------CIRRNMKSISCQEI 340

Query: 746 GRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCS-RGI 804
             Q+   R C      G    G   D           + G+WS W++W  C   C     
Sbjct: 341 PGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPT 400

Query: 805 RNRKRVCNNPEPKY 818
           R R+R+C    PKY
Sbjct: 401 RARQRLCTPLLPKY 414


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,413,419
Number of Sequences: 37866
Number of extensions: 2348966
Number of successful extensions: 7200
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 4898
Number of HSP's gapped (non-prelim): 1004
length of query: 1074
length of database: 18,247,518
effective HSP length: 113
effective length of query: 961
effective length of database: 13,968,660
effective search space: 13423882260
effective search space used: 13423882260
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.