Search of human proteins with 146219832

Search of human proteins with 146219832

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|146219832 myosin light chain kinase 3 [Homo sapiens]
         (819 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|146219832 myosin light chain kinase 3 [Homo sapiens]              1661   0.0  
gi|14993776 skeletal myosin light chain kinase [Homo sapiens]         452   e-127
gi|167466233 myosin light chain kinase family, member 4 [Homo sa...   442   e-124
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]       317   4e-86
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]       317   4e-86
gi|14670383 death-associated kinase 2 [Homo sapiens]                  247   4e-65
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          243   4e-64
gi|4557511 death-associated protein kinase 3 [Homo sapiens]           243   4e-64
gi|110349719 titin isoform N2-A [Homo sapiens]                        236   8e-62
gi|110349717 titin isoform novex-2 [Homo sapiens]                     236   8e-62
gi|110349713 titin isoform novex-1 [Homo sapiens]                     236   8e-62
gi|110349715 titin isoform N2-B [Homo sapiens]                        236   8e-62
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]      236   8e-62
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]      236   8e-62
gi|109255245 serine/threonine kinase 17a [Homo sapiens]               212   1e-54
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   194   3e-49
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   194   3e-49
gi|4758194 serine/threonine kinase 17B [Homo sapiens]                 191   2e-48
gi|157785645 SPEG complex locus [Homo sapiens]                        187   3e-47
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ...   186   1e-46
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...   184   2e-46
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   183   5e-46
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   182   8e-46
gi|27901803 protein serine kinase H1 [Homo sapiens]                   181   2e-45
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca...   180   4e-45
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   174   3e-43
gi|14916455 protein serine kinase H2 [Homo sapiens]                   174   4e-43
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   171   3e-42
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   171   3e-42
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   171   3e-42

>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
          Length = 819

 Score = 1661 bits (4301), Expect = 0.0
 Identities = 819/819 (100%), Positives = 819/819 (100%)

Query: 1   MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHL 60
           MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHL
Sbjct: 1   MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHL 60

Query: 61  ERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAA 120
           ERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAA
Sbjct: 61  ERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAA 120

Query: 121 VDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGV 180
           VDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGV
Sbjct: 121 VDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGV 180

Query: 181 QSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHL 240
           QSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHL
Sbjct: 181 QSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHL 240

Query: 241 PLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEE 300
           PLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEE
Sbjct: 241 PLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEE 300

Query: 301 GTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTL 360
           GTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTL
Sbjct: 301 GTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTL 360

Query: 361 TTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRA 420
           TTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRA
Sbjct: 361 TTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRA 420

Query: 421 GAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGA 480
           GAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGA
Sbjct: 421 GAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGA 480

Query: 481 EAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLP 540
           EAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLP
Sbjct: 481 EAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLP 540

Query: 541 LAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDR 600
           LAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDR
Sbjct: 541 LAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDR 600

Query: 601 ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLA 660
           ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLA
Sbjct: 601 ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLA 660

Query: 661 RRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAET 720
           RRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAET
Sbjct: 661 RRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAET 720

Query: 721 MNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRS 780
           MNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRS
Sbjct: 721 MNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRS 780

Query: 781 KTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP 819
           KTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP
Sbjct: 781 KTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP 819


>gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
          Length = 596

 Score =  452 bits (1164), Expect = e-127
 Identities = 267/590 (45%), Positives = 355/590 (60%), Gaps = 53/590 (8%)

Query: 271 VNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLP--AQARATHSG 328
           + + +PS + AP   +G +  RP    L  G    P    + P PP L   A+A A+  G
Sbjct: 10  LGIQNPSTDKAP---KGPTGERP----LAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKG 62

Query: 329 GETPPRISIHIQEMDTPGEMLM-TGRGSLGP-------TLTTEAPAAAQPGKQGPPGTGR 380
             T  + S   Q     G+       GS GP       T T E        +QG  G+  
Sbjct: 63  DGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS-- 120

Query: 381 CLQAPGT-EPGEQTPEG---ARELSP--LQESSSPGGVKAEEEQRAGAEPG--------- 425
             Q PG    G++  EG   AR  SP  L   S P  + + E+  A   P          
Sbjct: 121 --QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEG 178

Query: 426 -------TRPSLARSDDNDHEVGALGLQQG-KSPG-AGNPEPEQDCAARAPVRAEAVRRM 476
                  T P  A++++  + +     + G K+PG AG  + + D +     +A    + 
Sbjct: 179 VPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKS 238

Query: 477 PPGA--------EAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQ 528
             G         E    +LDD P PPAPF HR+V ++  ++S+ + +   E LGGG+FG 
Sbjct: 239 EVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGA 298

Query: 529 VHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLV 588
           V  C EK+TGL LAAK+IK ++ KD+E V  EI +MNQL+H NLIQLY A E+ H   L 
Sbjct: 299 VCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLF 358

Query: 589 MEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQT 648
           MEY++GGELF+RI DE YHLTE+D ++F RQIC+G+ ++H+  +LHLDLKPENILCVN T
Sbjct: 359 MEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTT 418

Query: 649 GHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSG 708
           GH +KIIDFGLARRY P EKLKVNFGTPEFL+PEVVNY+ +S  TDMWS+GVITYMLLSG
Sbjct: 419 GHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSG 478

Query: 709 LSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHE 768
           LSPFLG+ D ET+N +++ +W FD +TFE +S+EAKDFVS L+VK++  RM+A QCL H 
Sbjct: 479 LSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHP 538

Query: 769 WLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTS 818
           WLNNL  KA R   RLKSQ+LL+KY+ +R+WKK+F  V+AANR +K  +S
Sbjct: 539 WLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 588


>gi|167466233 myosin light chain kinase family, member 4 [Homo
           sapiens]
          Length = 388

 Score =  442 bits (1138), Expect = e-124
 Identities = 208/303 (68%), Positives = 254/303 (83%)

Query: 470 AEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQV 529
           A+   RMP  ++  S +  D PAPPAPF+HR+V+ K+ ++++ Y V + E+LGGGRFGQV
Sbjct: 61  ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV 120

Query: 530 HRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVM 589
           H+C E +TGL LAAKIIK +  KD+E+VKNEI++MNQL H NLIQLYDAFESK+   LVM
Sbjct: 121 HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM 180

Query: 590 EYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTG 649
           EYVDGGELFDRI DE Y+LTELD +LF +QICEG+ ++HQ YILHLDLKPENILCVN+  
Sbjct: 181 EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA 240

Query: 650 HQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGL 709
            QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNY+FVSFPTDMWSVGVI YMLLSGL
Sbjct: 241 KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL 300

Query: 710 SPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEW 769
           SPFLG+ DAET+N I+ C WD + + F+ +SEEAK+F+S+LL+KEKS R+SA++ LKH W
Sbjct: 301 SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW 360

Query: 770 LNN 772
           L++
Sbjct: 361 LSD 363


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score =  317 bits (811), Expect = 4e-86
 Identities = 172/364 (47%), Positives = 232/364 (63%), Gaps = 21/364 (5%)

Query: 454  GNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVK-ETSISAG 512
            G  EP Q+           V   P   +    V DD    P   ++R V++  E  +S  
Sbjct: 1411 GTSEPSQES------ELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF 1463

Query: 513  YEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNL 572
            Y++   E LG G+FGQV R  EK T    A K  K  SAK++E+++ EI+IMN L H  L
Sbjct: 1464 YDI--EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKL 1521

Query: 573  IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
            +Q  DAFE K +  +V+E V GGELF+RI DE + LTE + + + RQI EGV Y+H+  I
Sbjct: 1522 VQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGI 1581

Query: 633  LHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFP 692
            +HLDLKPENI+CVN+TG +IK+IDFGLARR +    LKV FGTPEF+APEV+NYE + + 
Sbjct: 1582 VHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYA 1641

Query: 693  TDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLV 752
            TDMWS+GVI Y+L+SGLSPF+G+ D ET+  + + +WDFD + F+ +S++AKDF+S LL 
Sbjct: 1642 TDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLK 1701

Query: 753  KEKSCRMSATQCLKHEWL----NNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTA 808
            K+   R+  TQCL+H WL     N+ AK   SK R+K      KY+A+RKW+K    V A
Sbjct: 1702 KDMKNRLDCTQCLQHPWLMKDTKNMEAK-KLSKDRMK------KYMARRKWQKTGNAVRA 1754

Query: 809  ANRL 812
              RL
Sbjct: 1755 IGRL 1758


>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
          Length = 1845

 Score =  317 bits (811), Expect = 4e-86
 Identities = 172/364 (47%), Positives = 232/364 (63%), Gaps = 21/364 (5%)

Query: 454  GNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVK-ETSISAG 512
            G  EP Q+           V   P   +    V DD    P   ++R V++  E  +S  
Sbjct: 1342 GTSEPSQES------ELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF 1394

Query: 513  YEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNL 572
            Y++   E LG G+FGQV R  EK T    A K  K  SAK++E+++ EI+IMN L H  L
Sbjct: 1395 YDI--EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKL 1452

Query: 573  IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
            +Q  DAFE K +  +V+E V GGELF+RI DE + LTE + + + RQI EGV Y+H+  I
Sbjct: 1453 VQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGI 1512

Query: 633  LHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFP 692
            +HLDLKPENI+CVN+TG +IK+IDFGLARR +    LKV FGTPEF+APEV+NYE + + 
Sbjct: 1513 VHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYA 1572

Query: 693  TDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLV 752
            TDMWS+GVI Y+L+SGLSPF+G+ D ET+  + + +WDFD + F+ +S++AKDF+S LL 
Sbjct: 1573 TDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLK 1632

Query: 753  KEKSCRMSATQCLKHEWL----NNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTA 808
            K+   R+  TQCL+H WL     N+ AK   SK R+K      KY+A+RKW+K    V A
Sbjct: 1633 KDMKNRLDCTQCLQHPWLMKDTKNMEAK-KLSKDRMK------KYMARRKWQKTGNAVRA 1685

Query: 809  ANRL 812
              RL
Sbjct: 1686 IGRL 1689


>gi|14670383 death-associated kinase 2 [Homo sapiens]
          Length = 370

 Score =  247 bits (630), Expect = 4e-65
 Identities = 136/321 (42%), Positives = 199/321 (61%), Gaps = 16/321 (4%)

Query: 505 KETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAK------DREDVK 558
           K+  +   Y++   E LG G+F  V +C EKSTGL  AAK IK + ++       RE+++
Sbjct: 15  KQQKVEDFYDI--GEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIE 72

Query: 559 NEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTR 618
            E++I+ Q+ H N+I L+D +E++    L++E V GGELFD +  +K  L+E +   F +
Sbjct: 73  REVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLA-QKESLSEEEATSFIK 131

Query: 619 QICEGVHYLHQHYILHLDLKPENILCVNQTGH--QIKIIDFGLARRYKPREKLKVNFGTP 676
           QI +GV+YLH   I H DLKPENI+ +++      IK+IDFGLA   +   + K  FGTP
Sbjct: 132 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 191

Query: 677 EFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTF 736
           EF+APE+VNYE +    DMWS+GVITY+LLSG SPFLG+T  ET+  I   S+DFD + F
Sbjct: 192 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFF 251

Query: 737 EGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQ---KY 793
              SE AKDF+ +LLVKE   R++  + L+H W+   P    ++  R +S + L+   K 
Sbjct: 252 SQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT--PVDNQQAMVRRESVVNLENFRKQ 309

Query: 794 IAQRKWKKHFYVVTAANRLRK 814
             +R+WK  F +V+  N L +
Sbjct: 310 YVRRRWKLSFSIVSLCNHLTR 330


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  243 bits (621), Expect = 4e-64
 Identities = 133/307 (43%), Positives = 191/307 (62%), Gaps = 14/307 (4%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD------REDVKNEINIMNQLSHVNL 572
           E LG G+F  V +C EKSTGL  AAK IK +  K       RED++ E++I+ ++ H N+
Sbjct: 17  EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76

Query: 573 IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
           I L++ +E+K    L++E V GGELFD +  EK  LTE +   F +QI  GV+YLH   I
Sbjct: 77  ITLHEVYENKTDVILILELVAGGELFDFLA-EKESLTEEEATEFLKQILNGVYYLHSLQI 135

Query: 633 LHLDLKPENILCV--NQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVS 690
            H DLKPENI+ +  N    +IKIIDFGLA +     + K  FGTPEF+APE+VNYE + 
Sbjct: 136 AHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 195

Query: 691 FPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRL 750
              DMWS+GVITY+LLSG SPFLG+T  ET+  +   +++F+ + F   S  AKDF+ RL
Sbjct: 196 LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRL 255

Query: 751 LVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQ---KYIAQRKWKKHFYVVT 807
           LVK+   RM+    L+H W+   P    ++ +R  S + ++   K+ A++KWK+   +++
Sbjct: 256 LVKDPKKRMTIQDSLQHPWIK--PKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLIS 313

Query: 808 AANRLRK 814
              RL +
Sbjct: 314 LCQRLSR 320


>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
          Length = 454

 Score =  243 bits (621), Expect = 4e-64
 Identities = 127/271 (46%), Positives = 172/271 (63%), Gaps = 9/271 (3%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD------REDVKNEINIMNQLSHVNL 572
           E LG G+F  V +C +K TG   AAK IK +          RE+++ E+NI+ ++ H N+
Sbjct: 17  EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNI 76

Query: 573 IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
           I L+D FE+K    L++E V GGELFD +  EK  LTE +   F +QI +GVHYLH   I
Sbjct: 77  ITLHDIFENKTDVVLILELVSGGELFDFLA-EKESLTEDEATQFLKQILDGVHYLHSKRI 135

Query: 633 LHLDLKPENILCV--NQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVS 690
            H DLKPENI+ +  N    +IK+IDFG+A + +   + K  FGTPEF+APE+VNYE + 
Sbjct: 136 AHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLG 195

Query: 691 FPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRL 750
              DMWS+GVITY+LLSG SPFLGET  ET+  I   ++DFD + F   SE AKDF+ RL
Sbjct: 196 LEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRL 255

Query: 751 LVKEKSCRMSATQCLKHEWLNNLPAKASRSK 781
           LVK+   RM+  Q L+H W+  +  +  R +
Sbjct: 256 LVKDPKRRMTIAQSLEHSWIKAIRRRNVRGE 286


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  236 bits (601), Expect = 8e-62
 Identities = 127/319 (39%), Positives = 193/319 (60%), Gaps = 9/319 (2%)

Query: 498   EHRVVSVKETSISAGYEVCQH----EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD 553
             E R VS+ + S S+  E+ +     E LG G FG VHRC E S+     AK +KVK   D
Sbjct: 31230 ETREVSMTKASHSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-D 31288

Query: 554   REDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDV 613
             +  VK EI+I+N   H N++ L+++FES     ++ E++ G ++F+RI    + L E ++
Sbjct: 31289 QVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREI 31348

Query: 614   VLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNF 673
             V +  Q+CE + +LH H I H D++PENI+   +    IKII+FG AR+ KP +  ++ F
Sbjct: 31349 VSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLF 31408

Query: 674   GTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDA 733
               PE+ APEV  ++ VS  TDMWS+G + Y+LLSG++PFL ET+ + +  I+N  + FD 
Sbjct: 31409 TAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDE 31468

Query: 734   DTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKY 793
             + F+ +S EA DFV RLLVKE+  RM+A++ L+H WL     K  R  T++   L  ++Y
Sbjct: 31469 EAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ---KIERVSTKVIRTLKHRRY 31525

Query: 794   IAQRKWKKHFYVVTAANRL 812
                   KK   +V +A R+
Sbjct: 31526 Y-HTLIKKDLNMVVSAARI 31543



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 68/334 (20%), Positives = 111/334 (33%), Gaps = 49/334 (14%)

Query: 192   QKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLP---------- 241
             +KA  +      LPP++   +   P + V        VP   +A P  +P          
Sbjct: 10704 KKAPAVVAKKPELPPVKVPEV---PKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEK 10760

Query: 242   ---LPTKVE---AKAPETPSENLRTGLELAPAPGRVNVVSPSL-----EVAPGAGQGASS 290
                +P K E   AK PE P + +       P P R     P +     E+AP        
Sbjct: 10761 KVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEE 10820

Query: 291   SRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLM 350
              +P P   EE         P+ P PP +P + +      + P            P    +
Sbjct: 10821 EKPVPVAEEE--------EPEVP-PPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKV 10871

Query: 351   TGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPG 410
               +  L P      PA  +   +      + +         Q PE   EL+PL+    PG
Sbjct: 10872 IEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKV-ELTPLK---VPG 10927

Query: 411   GVKAEEEQRAGAEPGTRPSLA-------RSDDNDHEVGALGLQQGKSPGAGNPEPEQDC- 462
             G K   +     +P  +  +        R ++ + +V    L++ K P    P P +   
Sbjct: 10928 GEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVE 10987

Query: 463   AARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAP 496
                 P   +  R++P   +   +     PA P P
Sbjct: 10988 EVEVPTVTKRERKIPEPTKVPEI----KPAIPLP 11017



 Score = 30.0 bits (66), Expect = 9.1
 Identities = 29/119 (24%), Positives = 43/119 (36%), Gaps = 21/119 (17%)

Query: 230  PGPAQAFPGHLPLPTKVE---AKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQ 286
            P P +  P  +P+P KVE    K PE P + +    +  P P +     P +   P    
Sbjct: 9295 PAPEEVAP--VPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVP---- 9348

Query: 287  GASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTP 345
                 +P PE           P P        PA+      G  T  +I+I  Q  ++P
Sbjct: 9349 ----KKPVPE--------EKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESP 9395


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  236 bits (601), Expect = 8e-62
 Identities = 127/319 (39%), Positives = 193/319 (60%), Gaps = 9/319 (2%)

Query: 498   EHRVVSVKETSISAGYEVCQH----EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD 553
             E R VS+ + S S+  E+ +     E LG G FG VHRC E S+     AK +KVK   D
Sbjct: 24925 ETREVSMTKASHSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-D 24983

Query: 554   REDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDV 613
             +  VK EI+I+N   H N++ L+++FES     ++ E++ G ++F+RI    + L E ++
Sbjct: 24984 QVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREI 25043

Query: 614   VLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNF 673
             V +  Q+CE + +LH H I H D++PENI+   +    IKII+FG AR+ KP +  ++ F
Sbjct: 25044 VSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLF 25103

Query: 674   GTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDA 733
               PE+ APEV  ++ VS  TDMWS+G + Y+LLSG++PFL ET+ + +  I+N  + FD 
Sbjct: 25104 TAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDE 25163

Query: 734   DTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKY 793
             + F+ +S EA DFV RLLVKE+  RM+A++ L+H WL     K  R  T++   L  ++Y
Sbjct: 25164 EAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ---KIERVSTKVIRTLKHRRY 25220

Query: 794   IAQRKWKKHFYVVTAANRL 812
                   KK   +V +A R+
Sbjct: 25221 Y-HTLIKKDLNMVVSAARI 25238


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score =  236 bits (601), Expect = 8e-62
 Identities = 127/319 (39%), Positives = 193/319 (60%), Gaps = 9/319 (2%)

Query: 498   EHRVVSVKETSISAGYEVCQH----EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD 553
             E R VS+ + S S+  E+ +     E LG G FG VHRC E S+     AK +KVK   D
Sbjct: 24858 ETREVSMTKASHSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-D 24916

Query: 554   REDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDV 613
             +  VK EI+I+N   H N++ L+++FES     ++ E++ G ++F+RI    + L E ++
Sbjct: 24917 QVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREI 24976

Query: 614   VLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNF 673
             V +  Q+CE + +LH H I H D++PENI+   +    IKII+FG AR+ KP +  ++ F
Sbjct: 24977 VSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLF 25036

Query: 674   GTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDA 733
               PE+ APEV  ++ VS  TDMWS+G + Y+LLSG++PFL ET+ + +  I+N  + FD 
Sbjct: 25037 TAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDE 25096

Query: 734   DTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKY 793
             + F+ +S EA DFV RLLVKE+  RM+A++ L+H WL     K  R  T++   L  ++Y
Sbjct: 25097 EAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ---KIERVSTKVIRTLKHRRY 25153

Query: 794   IAQRKWKKHFYVVTAANRL 812
                   KK   +V +A R+
Sbjct: 25154 Y-HTLIKKDLNMVVSAARI 25171


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score =  236 bits (601), Expect = 8e-62
 Identities = 127/319 (39%), Positives = 193/319 (60%), Gaps = 9/319 (2%)

Query: 498   EHRVVSVKETSISAGYEVCQH----EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD 553
             E R VS+ + S S+  E+ +     E LG G FG VHRC E S+     AK +KVK   D
Sbjct: 24733 ETREVSMTKASHSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-D 24791

Query: 554   REDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDV 613
             +  VK EI+I+N   H N++ L+++FES     ++ E++ G ++F+RI    + L E ++
Sbjct: 24792 QVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREI 24851

Query: 614   VLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNF 673
             V +  Q+CE + +LH H I H D++PENI+   +    IKII+FG AR+ KP +  ++ F
Sbjct: 24852 VSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLF 24911

Query: 674   GTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDA 733
               PE+ APEV  ++ VS  TDMWS+G + Y+LLSG++PFL ET+ + +  I+N  + FD 
Sbjct: 24912 TAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDE 24971

Query: 734   DTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKY 793
             + F+ +S EA DFV RLLVKE+  RM+A++ L+H WL     K  R  T++   L  ++Y
Sbjct: 24972 EAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ---KIERVSTKVIRTLKHRRY 25028

Query: 794   IAQRKWKKHFYVVTAANRL 812
                   KK   +V +A R+
Sbjct: 25029 Y-HTLIKKDLNMVVSAARI 25046


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score =  236 bits (601), Expect = 8e-62
 Identities = 149/364 (40%), Positives = 195/364 (53%), Gaps = 72/364 (19%)

Query: 454  GNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVK-ETSISAG 512
            G  EP Q+           V   P   +    V DD    P   ++R V++  E  +S  
Sbjct: 1411 GTSEPSQES------ELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF 1463

Query: 513  YEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNL 572
            Y++   E LG G+FGQV R  EK T    A K  K  SAK++E+++ EI+IMN L H  L
Sbjct: 1464 YDI--EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKL 1521

Query: 573  IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
            +Q  DAFE K +  +V+E V GGELF+RI DE + LTE + + + RQI EGV Y+H+  I
Sbjct: 1522 VQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGI 1581

Query: 633  LHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFP 692
            +HLDLKPENI+CVN+TG +IK+IDFGLARR +    LKV FGTPEF+APEV+NYE + + 
Sbjct: 1582 VHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYA 1641

Query: 693  TDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLV 752
            TDMWS+GVI Y+L                                          +RL  
Sbjct: 1642 TDMWSIGVICYIL------------------------------------------NRL-- 1657

Query: 753  KEKSCRMSATQCLKHEWL----NNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTA 808
                     TQCL+H WL     N+ AK   SK R+K      KY+A+RKW+K    V A
Sbjct: 1658 -------DCTQCLQHPWLMKDTKNMEAK-KLSKDRMK------KYMARRKWQKTGNAVRA 1703

Query: 809  ANRL 812
              RL
Sbjct: 1704 IGRL 1707


>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
          Length = 1794

 Score =  236 bits (601), Expect = 8e-62
 Identities = 149/364 (40%), Positives = 195/364 (53%), Gaps = 72/364 (19%)

Query: 454  GNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVK-ETSISAG 512
            G  EP Q+           V   P   +    V DD    P   ++R V++  E  +S  
Sbjct: 1342 GTSEPSQES------ELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF 1394

Query: 513  YEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNL 572
            Y++   E LG G+FGQV R  EK T    A K  K  SAK++E+++ EI+IMN L H  L
Sbjct: 1395 YDI--EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKL 1452

Query: 573  IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
            +Q  DAFE K +  +V+E V GGELF+RI DE + LTE + + + RQI EGV Y+H+  I
Sbjct: 1453 VQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGI 1512

Query: 633  LHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFP 692
            +HLDLKPENI+CVN+TG +IK+IDFGLARR +    LKV FGTPEF+APEV+NYE + + 
Sbjct: 1513 VHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYA 1572

Query: 693  TDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLV 752
            TDMWS+GVI Y+L                                          +RL  
Sbjct: 1573 TDMWSIGVICYIL------------------------------------------NRL-- 1588

Query: 753  KEKSCRMSATQCLKHEWL----NNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTA 808
                     TQCL+H WL     N+ AK   SK R+K      KY+A+RKW+K    V A
Sbjct: 1589 -------DCTQCLQHPWLMKDTKNMEAK-KLSKDRMK------KYMARRKWQKTGNAVRA 1634

Query: 809  ANRL 812
              RL
Sbjct: 1635 IGRL 1638


>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
          Length = 414

 Score =  212 bits (540), Expect = 1e-54
 Identities = 123/309 (39%), Positives = 183/309 (59%), Gaps = 17/309 (5%)

Query: 478 PGAEAGSVV----LDDSPAPPAPFEHRVVS------VKETSISAGYEVCQHEVLGGGRFG 527
           PGA +GS      L     PP P + R +       V+      GY +C    LG G+F 
Sbjct: 14  PGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFA 73

Query: 528 QVHRCTEKSTGLPLAAKIIKV--KSAKDREDVKNEINIMNQLSHVN--LIQLYDAFESKH 583
            V +C +K +G   AAK ++   K    R ++ +EI ++ +L+  N  +I L++ +E+  
Sbjct: 74  VVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVL-ELAQDNPWVINLHEVYETAS 132

Query: 584 SCTLVMEYVDGGELFDR-ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENI 642
              LV+EY  GGE+FD+ + D +    E DV    RQI EGVH+LH   ++HLDLKP+NI
Sbjct: 133 EMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNI 192

Query: 643 LCVNQTG-HQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVI 701
           L  +++    IKI+DFGL+R  K  E+L+   GTPE++APE+++Y+ +S  TDMWS+GV+
Sbjct: 193 LLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVL 252

Query: 702 TYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSA 761
           TY++L+G+SPFLG    ET   I   +  +  + F+ LSE A DF+  LLVK+   R +A
Sbjct: 253 TYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATA 312

Query: 762 TQCLKHEWL 770
            +CLKH WL
Sbjct: 313 EECLKHPWL 321


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  194 bits (493), Expect = 3e-49
 Identities = 107/298 (35%), Positives = 169/298 (56%), Gaps = 5/298 (1%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDRED-VKNEINIMNQLSHVNLIQLYD 577
           E LG G F +V    EK+TG   A K I  K+ K +E  ++NEI ++ ++ H N++ L D
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86

Query: 578 AFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDL 637
            +ES +   LVM+ V GGELFDRI ++ ++ TE D     RQ+ + V+YLH+  I+H DL
Sbjct: 87  IYESPNHLYLVMQLVSGGELFDRIVEKGFY-TEKDASTLIRQVLDAVYYLHRMGIVHRDL 145

Query: 638 KPENILCVNQTGH-QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMW 696
           KPEN+L  +Q    +I I DFGL++     + +    GTP ++APEV+  +  S   D W
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCW 205

Query: 697 SVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKS 756
           S+GVI Y+LL G  PF  E D++    I+   ++FD+  ++ +S+ AKDF+  L+ K+ +
Sbjct: 206 SIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPN 265

Query: 757 CRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRK 814
            R +  Q  +H W+    A        + +Q  ++K  A+ KW++ F        +RK
Sbjct: 266 KRYTCEQAARHPWIAGDTALNKNIHESVSAQ--IRKNFAKSKWRQAFNATAVVRHMRK 321


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  194 bits (493), Expect = 3e-49
 Identities = 107/298 (35%), Positives = 169/298 (56%), Gaps = 5/298 (1%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDRED-VKNEINIMNQLSHVNLIQLYD 577
           E LG G F +V    EK+TG   A K I  K+ K +E  ++NEI ++ ++ H N++ L D
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86

Query: 578 AFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDL 637
            +ES +   LVM+ V GGELFDRI ++ ++ TE D     RQ+ + V+YLH+  I+H DL
Sbjct: 87  IYESPNHLYLVMQLVSGGELFDRIVEKGFY-TEKDASTLIRQVLDAVYYLHRMGIVHRDL 145

Query: 638 KPENILCVNQTGH-QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMW 696
           KPEN+L  +Q    +I I DFGL++     + +    GTP ++APEV+  +  S   D W
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCW 205

Query: 697 SVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKS 756
           S+GVI Y+LL G  PF  E D++    I+   ++FD+  ++ +S+ AKDF+  L+ K+ +
Sbjct: 206 SIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPN 265

Query: 757 CRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRK 814
            R +  Q  +H W+    A        + +Q  ++K  A+ KW++ F        +RK
Sbjct: 266 KRYTCEQAARHPWIAGDTALNKNIHESVSAQ--IRKNFAKSKWRQAFNATAVVRHMRK 321


>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
          Length = 372

 Score =  191 bits (486), Expect = 2e-48
 Identities = 106/256 (41%), Positives = 157/256 (61%), Gaps = 7/256 (2%)

Query: 521 LGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD--REDVKNEINIMNQL-SHVNLIQLYD 577
           LG G+F  V +C  KSTG   AAK +K +      R ++ +EI ++    S   +I L++
Sbjct: 39  LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHE 98

Query: 578 AFESKHSCTLVMEYVDGGELFDRITDEKYHL-TELDVVLFTRQICEGVHYLHQHYILHLD 636
            +E+     L++EY  GGE+F     E   + +E DV+   +QI EGV+YLHQ+ I+HLD
Sbjct: 99  VYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLD 158

Query: 637 LKPENILC--VNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTD 694
           LKP+NIL   +   G  IKI+DFG++R+     +L+   GTPE+LAPE++NY+ ++  TD
Sbjct: 159 LKPQNILLSSIYPLG-DIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATD 217

Query: 695 MWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKE 754
           MW++G+I YMLL+  SPF+GE + ET   I   + D+  +TF  +S+ A DF+  LLVK 
Sbjct: 218 MWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKN 277

Query: 755 KSCRMSATQCLKHEWL 770
              R +A  CL H WL
Sbjct: 278 PEKRPTAEICLSHSWL 293


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score =  187 bits (475), Expect = 3e-47
 Identities = 105/286 (36%), Positives = 166/286 (58%), Gaps = 12/286 (4%)

Query: 518  HEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYD 577
            H+ +G G F  + R  E+S+GL  AAK I    AK +   + E  ++ +L H  ++  ++
Sbjct: 1604 HQEIGRGAFSYLRRIVERSSGLEFAAKFIP-SQAKPKASARREARLLARLQHDCVLYFHE 1662

Query: 578  AFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDL 637
            AFE +    +V E     EL +RI   K  + E ++  + RQ+ EG+HYLHQ ++LHLD+
Sbjct: 1663 AFERRRGLVIVTELCTE-ELLERIA-RKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDV 1720

Query: 638  KPENILCVNQTG--HQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDM 695
            KPEN+L  +      Q++I DFG A+   P E     +GTPEF+APE+VN   VS  TD+
Sbjct: 1721 KPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDI 1780

Query: 696  WSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEK 755
            W VGV+ ++ L+G+SPF+GE D  T+  I N +  F+  TF  LS EA+ F+ ++LV+++
Sbjct: 1781 WPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDR 1840

Query: 756  SCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKK 801
              R +A + L+H W       A  S   LK       ++++R+W++
Sbjct: 1841 -LRPTAEETLEHPWFKTQAKGAEVSTDHLK------LFLSRRRWQR 1879



 Score =  162 bits (410), Expect = 1e-39
 Identities = 136/500 (27%), Positives = 212/500 (42%), Gaps = 59/500 (11%)

Query: 363  EAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEG------------ARELSPLQESSSPG 410
            EAP  ++P +  PP +   L AP   P   TP              ++ LS L+    P 
Sbjct: 2784 EAPVTSRPARARPPDSPTSL-APPLAPAAPTPPSVTVSPSSPPTPPSQALSSLKAVGPPP 2842

Query: 411  GVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRA 470
                   +   A     P+L  +     E     L  G    A  P+  +  ++  PV  
Sbjct: 2843 QTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVKPVSSSTPVYV 2902

Query: 471  -EAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQH----------- 518
              +    PP  E         PAP  P E   V+V+  S+S   EV              
Sbjct: 2903 VTSFVSAPPAPEP--------PAPEPPPEPTKVTVQ--SLSPAKEVVSSPGSSPRSSPRP 2952

Query: 519  -----------------EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEI 561
                             E    GRFG V  C E +TG    AKI+   +A+ +  V  E 
Sbjct: 2953 EGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVAKIVPY-AAEGKRRVLQEY 3011

Query: 562  NIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQIC 621
             ++  L H  ++ L++A+ +     L+ E     EL   ++D ++  +E DV  +  Q+ 
Sbjct: 3012 EVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSD-RFRYSEDDVATYMVQLL 3070

Query: 622  EGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPR--EKLKVNFGTPEFL 679
            +G+ YLH H++LHLD+KP+N+L        +KI+DFG A+ Y P+    L    GT EF+
Sbjct: 3071 QGLDYLHGHHVLHLDIKPDNLLLAPDNA--LKIVDFGSAQPYNPQALRPLGHRTGTLEFM 3128

Query: 680  APEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGL 739
            APE+V  E +   TD+W  GV+TY++LSG SPF      ET   IV   +D     +   
Sbjct: 3129 APEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFD-AFQLYPNT 3187

Query: 740  SEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKW 799
            S+ A  F+ ++L      R S   CL H WL +      R +T   +   L++++ +++ 
Sbjct: 3188 SQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRR 3247

Query: 800  KKHFYVVTAANRLRKFPTSP 819
            ++          LR +P  P
Sbjct: 3248 RRAEAATRHKVLLRSYPGGP 3267



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 93/329 (28%), Positives = 118/329 (35%), Gaps = 59/329 (17%)

Query: 200  TAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQA-FPGH----LPLPTKVEAKA-PET 253
            T  R PP  + GL +          +   VP P Q  F G       +PT+ EA   PET
Sbjct: 1907 TMPRRPP-PSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPET 1965

Query: 254  PS-------ENLRTGLELAPAPGRVNVVSPSLEVAPGA---------GQGASSSRPDPEP 297
             +       E  R   +   AP    + SP  E A GA         G  A S+ P   P
Sbjct: 1966 GAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGP 2025

Query: 298  LEEGTRLTPGPGPQCPG----PPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGR 353
             E G  L      + P      PG    AR     GE   R+    Q +   G       
Sbjct: 2026 RELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVS 2085

Query: 354  GSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTE--PGEQTPEGARELSPLQESSSPGG 411
            G  GP L +    A  P         R  +A  +E  P  Q P    E   LQ+SSS   
Sbjct: 2086 GLRGPLLESLGGRARDP---------RMARAASSEAAPHHQPP---LENRGLQKSSSFSQ 2133

Query: 412  VKAE---EEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGA-GNPEPEQDCAARAP 467
             +AE     +RAGA P   P +AR       +GA  LQ+  S  A    +P       AP
Sbjct: 2134 GEAEPRGRHRRAGA-PLEIP-VAR-------LGARRLQESPSLSALSEAQPSSPARPSAP 2184

Query: 468  VRAEAVRRMPPGAEAGSVVLDDSPAPPAP 496
              +      P  AE  +    D+P PPAP
Sbjct: 2185 KPST-----PKSAEPSATTPSDAPQPPAP 2208



 Score = 37.4 bits (85), Expect = 0.057
 Identities = 71/296 (23%), Positives = 100/296 (33%), Gaps = 49/296 (16%)

Query: 150 RGSPGDSPEENKERVEEEGG--KPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPI 207
           RG+P  +P  ++E +   G   + + +        D R   + S  +D+    A+ L  I
Sbjct: 443 RGAPWGTPGASQEELRAPGSVAERRRLFQQKAASLDERTR-QRSPASDLELRFAQELGRI 501

Query: 208 RASGLGADPAQAVVS-PGQGDGVPGPAQAFPGHLPLPTKVE-----------AKAPETPS 255
           R S    +  ++  S        P P +  PG  PL ++             A  P +PS
Sbjct: 502 RRSTSREELVRSHESLRATLQRAPSPRE--PGEPPLFSRPSTPKTSRAVSPAAAQPPSPS 559

Query: 256 ENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGP 315
              + G E    PGR     P+    PG G      R D  PL     +     P  P P
Sbjct: 560 SAEKPGDE----PGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSP-VPPP 614

Query: 316 PGLPAQARATHSGG--ETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQ 373
              P +AR     G    PP  ++      TPG   + G            P   +  + 
Sbjct: 615 AADPPEARTKAPPGRKREPPAQAVRFLPWATPG---LEG---------AAVPQTLEKNRA 662

Query: 374 GPPGTGRCLQAPGTEPGEQTP------------EGARELSPLQESSSPGGVKAEEE 417
           GP    R  + P  E G   P              AR  SP  ESS    V A EE
Sbjct: 663 GPEAEKRLRRGP-EEDGPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEE 717



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 56/221 (25%), Positives = 68/221 (30%), Gaps = 17/221 (7%)

Query: 179  GVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPG 238
            G Q  +  P    Q+A V    A   PP   + L    A A  +P      P      P 
Sbjct: 2770 GTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPTPPS 2829

Query: 239  HLPLPTKVEAKAPETPSENLRTGLELA-PAPGRVNVVSPSLEVAPGAGQGASSSRPDPEP 297
                  K     P+TP    R GL+ A PA   +    PS  V P        S P P  
Sbjct: 2830 QALSSLKAVGPPPQTPPRRHR-GLQAARPAEPTL----PSTHVTP--------SEPKPFV 2876

Query: 298  LEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLG 357
            L+ GT + P   PQ   P           S    PP       E   P E       SL 
Sbjct: 2877 LDTGTPI-PASTPQGVKPVSSSTPVYVVTSFVSAPPAPEPPAPE--PPPEPTKVTVQSLS 2933

Query: 358  PTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGAR 398
            P     +   + P     P      Q P  +P     E AR
Sbjct: 2934 PAKEVVSSPGSSPRSSPRPEGTTLRQGPPQKPYTFLEEKAR 2974



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 54/204 (26%), Positives = 68/204 (33%), Gaps = 64/204 (31%)

Query: 335 ISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAA-AQP---------------GKQGPPGT 378
           +SIH+     P   L      L P L +EAP   AQP               GK+ PPG 
Sbjct: 268 LSIHVS---VPQSGLRREEPDLQPQLASEAPRRPAQPPPSKSALLPPPSPRVGKRSPPGP 324

Query: 379 GRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDH 438
                A  T P  +T E       L E ++       EE+R      + PSLA       
Sbjct: 325 PAQPAATPTSPHRRTQEPV-----LPEDTT------TEEKRGKKSKSSGPSLA------- 366

Query: 439 EVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDD--------- 489
                        G     P Q   + A  R  A+ R P    AGS +LD          
Sbjct: 367 -------------GTAESRP-QTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRR 412

Query: 490 ----SPAPPAPFEHRVVSVKETSI 509
               S +PPAP    V   K  S+
Sbjct: 413 SLERSDSPPAPLRPWVPLRKARSL 436



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 39/150 (26%), Positives = 54/150 (36%), Gaps = 35/150 (23%)

Query: 345 PGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQ 404
           PGE  +  R S   T    +PAAAQP            + PG EPG     G        
Sbjct: 530 PGEPPLFSRPSTPKTSRAVSPAAAQPPSPS------SAEKPGDEPGRPRSRGP------A 577

Query: 405 ESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAA 464
             + PG    +E +R    P TR              +  +Q+ +SP         +   
Sbjct: 578 GRTEPGEGPQQEVRRRDQFPLTR--------------SRAIQECRSPVPPPAADPPEART 623

Query: 465 RAP------VRAEAVRRMP---PGAEAGSV 485
           +AP        A+AVR +P   PG E  +V
Sbjct: 624 KAPPGRKREPPAQAVRFLPWATPGLEGAAV 653


>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
           sapiens]
          Length = 473

 Score =  186 bits (471), Expect = 1e-46
 Identities = 113/294 (38%), Positives = 169/294 (57%), Gaps = 8/294 (2%)

Query: 521 LGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFE 580
           LG G    V+RC +K T  P A K++K     D++ V+ EI ++ +LSH N+I+L + FE
Sbjct: 52  LGRGATSIVYRCKQKGTQKPYALKVLK--KTVDKKIVRTEIGVLLRLSHPNIIKLKEIFE 109

Query: 581 SKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPE 640
           +    +LV+E V GGELFDRI ++ Y+ +E D     +QI E V YLH++ I+H DLKPE
Sbjct: 110 TPTEISLVLELVTGGELFDRIVEKGYY-SERDAADAVKQILEAVAYLHENGIVHRDLKPE 168

Query: 641 NILCVNQTGHQ-IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVG 699
           N+L         +KI DFGL++  + +  +K   GTP + APE++         DMWSVG
Sbjct: 169 NLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVG 228

Query: 700 VITYMLLSGLSPFLGETDAETM-NFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCR 758
           +ITY+LL G  PF  E   + M   I+NC + F +  ++ +S  AKD V +L+V +   R
Sbjct: 229 IITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKR 288

Query: 759 MSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRL 812
           ++  Q L+H W+    A      T   +Q  LQ++ A+RK K     V A++RL
Sbjct: 289 LTTFQALQHPWVTGKAANFVHMDT---AQKKLQEFNARRKLKAAVKAVVASSRL 339


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score =  184 bits (468), Expect = 2e-46
 Identities = 110/305 (36%), Positives = 169/305 (55%), Gaps = 9/305 (2%)

Query: 513  YEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNL 572
            YEV   E +G G FG V R   K   +  AAK I ++S + R     E +I+  LSH  +
Sbjct: 6468 YEV--KEEIGRGVFGFVKRVQHKGNKILCAAKFIPLRS-RTRAQAYRERDILAALSHPLV 6524

Query: 573  IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
              L D FE++ +  L++E     EL DR+   K  +TE +V ++ +Q+ EG+HYLH H +
Sbjct: 6525 TGLLDQFETRKTLILILELCSSEELLDRLY-RKGVVTEAEVKVYIQQLVEGLHYLHSHGV 6583

Query: 633  LHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFP 692
            LHLD+KP NIL V+     IKI DFG A+   P E     +G+PEF++PE++    VS  
Sbjct: 6584 LHLDIKPSNILMVHPAREDIKICDFGFAQNITPAELQFSQYGSPEFVSPEIIQQNPVSEA 6643

Query: 693  TDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLV 752
            +D+W++GVI+Y+ L+  SPF GE+D  T+  ++     + +     LSE+AKDF+   L 
Sbjct: 6644 SDIWAMGVISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQ 6703

Query: 753  KEKSCRMSATQCLKHEW-LNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANR 811
            +    R SA QCL H W L ++PA+ +      + + LL    A+ +W++      +   
Sbjct: 6704 RAPQARPSAAQCLSHPWFLKSMPAEEAHFINTKQLKFLL----ARSRWQRSLMSYKSILV 6759

Query: 812  LRKFP 816
            +R  P
Sbjct: 6760 MRSIP 6764



 Score =  103 bits (256), Expect = 8e-22
 Identities = 80/261 (30%), Positives = 125/261 (47%), Gaps = 13/261 (4%)

Query: 524  GRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKH 583
            GRF  V +C EK++G  LAAKII     KD+  V  E   +  L H +L QL+ A+ S  
Sbjct: 7681 GRFSVVRQCWEKASGRALAAKIIPYHP-KDKTAVLREYEALKGLRHPHLAQLHAAYLSPR 7739

Query: 584  SCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENIL 643
               L++E   G EL   +  E+   +E +V  +  Q+     YLH  +ILHLDL+ EN++
Sbjct: 7740 HLVLILELCSGPELLPCLA-ERASYSESEVKDYLWQMLSATQYLHNQHILHLDLRSENMI 7798

Query: 644  CVNQTGHQIKIIDFGLAR-----RYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSV 698
                  + +K++D G A+     +  P +K K      E +APE++  +     TD+W++
Sbjct: 7799 ITEY--NLLKVVDLGNAQSLSQEKVLPSDKFKDYL---ETMAPELLEGQGAVPQTDIWAI 7853

Query: 699  GVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCR 758
            GV  +++LS   P   E  A  +   +       +  + GLS  A  F+   L  +   R
Sbjct: 7854 GVTAFIMLSAEYPVSSE-GARDLQRGLRKGLVRLSRCYAGLSGGAVAFLRSTLCAQPWGR 7912

Query: 759  MSATQCLKHEWLNNLPAKASR 779
              A+ CL+  WL       SR
Sbjct: 7913 PCASSCLQCPWLTEEGPACSR 7933


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  183 bits (465), Expect = 5e-46
 Identities = 105/298 (35%), Positives = 164/298 (55%), Gaps = 5/298 (1%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDRE-DVKNEINIMNQLSHVNLIQLYD 577
           +VLG G F +V    +K T   +A K I  ++ + +E  ++NEI +++++ H N++ L D
Sbjct: 24  DVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDD 83

Query: 578 AFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDL 637
            +ES     L+M+ V GGELFDRI ++ ++ TE D      Q+ + V YLH   I+H DL
Sbjct: 84  IYESGGHLYLIMQLVSGGELFDRIVEKGFY-TERDASRLIFQVLDAVKYLHDLGIVHRDL 142

Query: 638 KPENILCVN-QTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMW 696
           KPEN+L  +     +I I DFGL++   P   L    GTP ++APEV+  +  S   D W
Sbjct: 143 KPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCW 202

Query: 697 SVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKS 756
           S+GVI Y+LL G  PF  E DA+    I+   ++FD+  ++ +S+ AKDF+  L+ K+  
Sbjct: 203 SIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPE 262

Query: 757 CRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRK 814
            R +  Q L+H W+    A        +  Q  ++K  A+ KWK+ F        +RK
Sbjct: 263 KRFTCEQALQHPWIAGDTALDKNIHQSVSEQ--IKKNFAKSKWKQAFNATAVVRHMRK 318


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  182 bits (463), Expect = 8e-46
 Identities = 107/297 (36%), Positives = 164/297 (55%), Gaps = 5/297 (1%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDA 578
           EVLG G F +V    ++ TG   A K IK   A     ++NEI ++ ++ H N++ L D 
Sbjct: 27  EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDI 86

Query: 579 FESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLK 638
           +ES     LVM+ V GGELFDRI +   + TE D  L  +Q+   V YLH++ I+H DLK
Sbjct: 87  YESTTHYYLVMQLVSGGELFDRILERGVY-TEKDASLVIQQVLSAVKYLHENGIVHRDLK 145

Query: 639 PENILCVN-QTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWS 697
           PEN+L +  +   +I I DFGL++  +    +    GTP ++APEV+  +  S   D WS
Sbjct: 146 PENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWS 204

Query: 698 VGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSC 757
           +GVITY+LL G  PF  ET+++    I    ++F++  ++ +SE AKDF+  LL K+ + 
Sbjct: 205 IGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNE 264

Query: 758 RMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRK 814
           R +  + L H W++     A          L +QK  A+ KW++ F      + +RK
Sbjct: 265 RYTCEKALSHPWIDG--NTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRK 319


>gi|27901803 protein serine kinase H1 [Homo sapiens]
          Length = 424

 Score =  181 bits (459), Expect = 2e-45
 Identities = 116/339 (34%), Positives = 180/339 (53%), Gaps = 20/339 (5%)

Query: 471 EAVRRMPPGAEAGSVVLDDSPAPPA----------PFEHRVVSVK---ETSISAGYEVCQ 517
           ++V  +  G  A S      P PP           P   RV   +   +  ++A Y++  
Sbjct: 43  DSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDI-- 100

Query: 518 HEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYD 577
             ++G G F +V R   ++T  P A K+I+ K  + RE  ++E+ ++ ++ H N+IQL +
Sbjct: 101 KALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVE 160

Query: 578 AFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDL 637
            FE++    +VME   GGELFDRI   K   TE D     + + +GV YLH   I H DL
Sbjct: 161 VFETQERVYMVMELATGGELFDRII-AKGSFTERDATRVLQMVLDGVRYLHALGITHRDL 219

Query: 638 KPENILCVNQ-TGHQIKIIDFGLARRYKPREK--LKVNFGTPEFLAPEVVNYEFVSFPTD 694
           KPEN+L  +  T  +I I DFGLA   K  +   +K   GTPE++APEV+  +  +   D
Sbjct: 220 KPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVD 279

Query: 695 MWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKE 754
           MW++GVI Y+LLSG  PF  +        I+   + +  + +  +S  AKDF+ RLL  +
Sbjct: 280 MWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVD 339

Query: 755 KSCRMSATQCLKHEWLNNLPAKAS-RSKTRLKSQLLLQK 792
              RM+A Q L+H W+ ++ A +S ++  R  SQ LL++
Sbjct: 340 PGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKR 378


>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform a [Homo sapiens]
          Length = 426

 Score =  180 bits (457), Expect = 4e-45
 Identities = 126/374 (33%), Positives = 188/374 (50%), Gaps = 21/374 (5%)

Query: 449 KSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETS 508
           K PGAG   P+   AARA        R P            S  P    +  ++  K T 
Sbjct: 45  KGPGAGPAGPQLREAARASSGLGGGGRHP------------SRIPAIALQDMLLLKKHTE 92

Query: 509 -ISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDRED-VKNEINIMNQ 566
            IS+ YE+   E LG G F +V    E+ +   +A K I  K+ + +E  V+NEI ++ +
Sbjct: 93  DISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRR 150

Query: 567 LSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHY 626
           +SH N++ L D  ES     L ME V GGELFDRI  E+   TE D      Q+   V Y
Sbjct: 151 ISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM-ERGSYTEKDASHLVGQVLGAVSY 209

Query: 627 LHQHYILHLDLKPENILCVNQ-TGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN 685
           LH   I+H DLKPEN+L        +I + DFGL++  +    L    GTP ++APE++ 
Sbjct: 210 LHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLE 268

Query: 686 YEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKD 745
            +      D+W++GVI+Y+LL G  PF  E+D E  + I+  S++FD+  ++ +SE AKD
Sbjct: 269 QKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKD 328

Query: 746 FVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYV 805
           F+  LL ++   R +  Q L+H W++   A        +  Q  ++K  A+  WK+ F  
Sbjct: 329 FIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQ--IRKNFARTHWKRAFNA 386

Query: 806 VTAANRLRKFPTSP 819
            +    +RK    P
Sbjct: 387 TSFLRHIRKLGQIP 400


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  174 bits (441), Expect = 3e-43
 Identities = 110/313 (35%), Positives = 168/313 (53%), Gaps = 8/313 (2%)

Query: 509 ISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDRED-VKNEINIMNQL 567
           IS+ YE+   E LG G F +V    E+ +   +A K I  K+ + +E  V+NEI ++ ++
Sbjct: 28  ISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRI 85

Query: 568 SHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYL 627
           SH N++ L D  ES     L ME V GGELFDRI  E+   TE D      Q+   V YL
Sbjct: 86  SHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM-ERGSYTEKDASHLVGQVLGAVSYL 144

Query: 628 HQHYILHLDLKPENILCVNQ-TGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNY 686
           H   I+H DLKPEN+L        +I + DFGL++  +    L    GTP ++APE++  
Sbjct: 145 HSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQ 203

Query: 687 EFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDF 746
           +      D+W++GVI+Y+LL G  PF  E+D E  + I+  S++FD+  ++ +SE AKDF
Sbjct: 204 KPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDF 263

Query: 747 VSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVV 806
           +  LL ++   R +  Q L+H W++   A        +  Q  ++K  A+  WK+ F   
Sbjct: 264 IRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQ--IRKNFARTHWKRAFNAT 321

Query: 807 TAANRLRKFPTSP 819
           +    +RK    P
Sbjct: 322 SFLRHIRKLGQIP 334


>gi|14916455 protein serine kinase H2 [Homo sapiens]
          Length = 385

 Score =  174 bits (440), Expect = 4e-43
 Identities = 115/346 (33%), Positives = 183/346 (52%), Gaps = 35/346 (10%)

Query: 452 GAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISA 511
           G G   P  + AA+A  R +  R                    A F+ RV+        A
Sbjct: 28  GVGGAGPGPEAAAQAAQRIQVARFR------------------AKFDPRVL--------A 61

Query: 512 GYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVN 571
            Y++    ++G G F +V R  +K+T  P A K+++ +  + RE   +E++++ ++SH  
Sbjct: 62  RYDI--KALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRY 119

Query: 572 LIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHY 631
           ++QL + FE++    +VME   GGELFDR+  +    TE D V   + + +G+ YLH   
Sbjct: 120 IVQLMEIFETEDQVYMVMELATGGELFDRLIAQG-SFTERDAVRILQMVADGIRYLHALQ 178

Query: 632 ILHLDLKPENILCVNQTGHQIKII--DFGLARRYKPREK--LKVNFGTPEFLAPEVVNYE 687
           I H +LKPEN+L  +  G + KI+  DFGLA   K      +K   GTPE++APEV+  +
Sbjct: 179 ITHRNLKPENLLYYHP-GEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRK 237

Query: 688 FVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFV 747
             +   DMW++GVITY LLSG  PF  E+       I+   +++  + +  +S  AKDF+
Sbjct: 238 PYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFI 297

Query: 748 SRLLVKEKSCRMSATQCLKHEWLNNLPAKAS-RSKTRLKSQLLLQK 792
            +LL+ E   RMSA Q L H W+  + A +S ++  R  S+ L+Q+
Sbjct: 298 DKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISRNLMQR 343


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  171 bits (433), Expect = 3e-42
 Identities = 104/286 (36%), Positives = 163/286 (56%), Gaps = 6/286 (2%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVK--SAKDREDVKNEINIMNQLSHVNLIQLY 576
           E LG G F  V RC +K++    AAKII  K  SA+D + ++ E  I   L H N+++L+
Sbjct: 18  EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77

Query: 577 DAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLD 636
           D+   +    LV + V GGELF+ I   +Y+ +E D      QI E V+++HQH I+H D
Sbjct: 78  DSISEEGFHYLVFDLVTGGELFEDIVAREYY-SEADASHCIHQILESVNHIHQHDIVHRD 136

Query: 637 LKPENILCVNQT-GHQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYEFVSFPTD 694
           LKPEN+L  ++  G  +K+ DFGLA   +  ++    F GTP +L+PEV+  +    P D
Sbjct: 137 LKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196

Query: 695 MWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKE 754
           +W+ GVI Y+LL G  PF  E   +    I   ++DF +  ++ ++ EAK+ ++++L   
Sbjct: 197 IWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTIN 256

Query: 755 KSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWK 800
            + R++A Q LKH W+      AS    R ++   L+K+ A+RK K
Sbjct: 257 PAKRITADQALKHPWVCQRSTVASMMH-RQETVECLRKFNARRKLK 301


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  171 bits (433), Expect = 3e-42
 Identities = 104/286 (36%), Positives = 163/286 (56%), Gaps = 6/286 (2%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVK--SAKDREDVKNEINIMNQLSHVNLIQLY 576
           E LG G F  V RC +K++    AAKII  K  SA+D + ++ E  I   L H N+++L+
Sbjct: 18  EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77

Query: 577 DAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLD 636
           D+   +    LV + V GGELF+ I   +Y+ +E D      QI E V+++HQH I+H D
Sbjct: 78  DSISEEGFHYLVFDLVTGGELFEDIVAREYY-SEADASHCIHQILESVNHIHQHDIVHRD 136

Query: 637 LKPENILCVNQT-GHQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYEFVSFPTD 694
           LKPEN+L  ++  G  +K+ DFGLA   +  ++    F GTP +L+PEV+  +    P D
Sbjct: 137 LKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196

Query: 695 MWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKE 754
           +W+ GVI Y+LL G  PF  E   +    I   ++DF +  ++ ++ EAK+ ++++L   
Sbjct: 197 IWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTIN 256

Query: 755 KSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWK 800
            + R++A Q LKH W+      AS    R ++   L+K+ A+RK K
Sbjct: 257 PAKRITADQALKHPWVCQRSTVASMMH-RQETVECLRKFNARRKLK 301


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  171 bits (433), Expect = 3e-42
 Identities = 104/286 (36%), Positives = 163/286 (56%), Gaps = 6/286 (2%)

Query: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVK--SAKDREDVKNEINIMNQLSHVNLIQLY 576
           E LG G F  V RC +K++    AAKII  K  SA+D + ++ E  I   L H N+++L+
Sbjct: 18  EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77

Query: 577 DAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLD 636
           D+   +    LV + V GGELF+ I   +Y+ +E D      QI E V+++HQH I+H D
Sbjct: 78  DSISEEGFHYLVFDLVTGGELFEDIVAREYY-SEADASHCIHQILESVNHIHQHDIVHRD 136

Query: 637 LKPENILCVNQT-GHQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYEFVSFPTD 694
           LKPEN+L  ++  G  +K+ DFGLA   +  ++    F GTP +L+PEV+  +    P D
Sbjct: 137 LKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196

Query: 695 MWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKE 754
           +W+ GVI Y+LL G  PF  E   +    I   ++DF +  ++ ++ EAK+ ++++L   
Sbjct: 197 IWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTIN 256

Query: 755 KSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWK 800
            + R++A Q LKH W+      AS    R ++   L+K+ A+RK K
Sbjct: 257 PAKRITADQALKHPWVCQRSTVASMMH-RQETVECLRKFNARRKLK 301


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,165,473
Number of Sequences: 37866
Number of extensions: 2403335
Number of successful extensions: 16166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 621
Number of HSP's successfully gapped in prelim test: 1434
Number of HSP's that attempted gapping in prelim test: 9699
Number of HSP's gapped (non-prelim): 4854
length of query: 819
length of database: 18,247,518
effective HSP length: 111
effective length of query: 708
effective length of database: 14,044,392
effective search space: 9943429536
effective search space used: 9943429536
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.