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Search of human proteins with 145312265
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145312265 endoplasmic reticulum to nucleus signalling 2
[Homo sapiens]
(974 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo... 1987 0.0
gi|153946421 endoplasmic reticulum to nucleus signalling 1 [Homo... 853 0.0
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 97 1e-19
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens] 88 4e-17
gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens] 88 4e-17
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 86 2e-16
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 86 2e-16
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 86 2e-16
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 86 2e-16
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 86 2e-16
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 86 2e-16
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 86 2e-16
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 86 2e-16
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 86 2e-16
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 86 2e-16
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 84 6e-16
gi|41872374 polo-like kinase 3 [Homo sapiens] 84 8e-16
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 83 1e-15
gi|115529463 protein kinase D1 [Homo sapiens] 83 1e-15
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 83 1e-15
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 83 1e-15
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 82 2e-15
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 82 2e-15
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 82 2e-15
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 82 2e-15
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 82 2e-15
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 82 2e-15
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 82 2e-15
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 82 2e-15
gi|121114283 polo-like kinase 4 [Homo sapiens] 82 3e-15
>gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo
sapiens]
Length = 974
Score = 1987 bits (5148), Expect = 0.0
Identities = 974/974 (100%), Positives = 974/974 (100%)
Query: 1 MRRAGIGEDSRLGLQAQPGAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWP 60
MRRAGIGEDSRLGLQAQPGAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWP
Sbjct: 1 MRRAGIGEDSRLGLQAQPGAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWP 60
Query: 61 RLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEG 120
RLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEG
Sbjct: 61 RLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEG 120
Query: 121 PMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDA 180
PMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDA
Sbjct: 121 PMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDA 180
Query: 181 WFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDG 240
WFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDG
Sbjct: 181 WFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDG 240
Query: 241 SPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDT 300
SPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDT
Sbjct: 241 SPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDT 300
Query: 301 LHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVP 360
LHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVP
Sbjct: 301 LHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVP 360
Query: 361 RGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTT 420
RGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTT
Sbjct: 361 RGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTT 420
Query: 421 MLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQD 480
MLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQD
Sbjct: 421 MLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQD 480
Query: 481 LLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQK 540
LLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQK
Sbjct: 481 LLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQK 540
Query: 541 RLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLR 600
RLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLR
Sbjct: 541 RLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLR 600
Query: 601 ECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGL 660
ECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGL
Sbjct: 601 ECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGL 660
Query: 661 EPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRC 720
EPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRC
Sbjct: 661 EPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRC 720
Query: 721 SFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQA 780
SFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQA
Sbjct: 721 SFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQA 780
Query: 781 NILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQ 840
NILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQ
Sbjct: 781 NILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQ 840
Query: 841 DVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRA 900
DVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRA
Sbjct: 841 DVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRA 900
Query: 901 VRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPP 960
VRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPP
Sbjct: 901 VRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPP 960
Query: 961 DSEARRPCPGATGR 974
DSEARRPCPGATGR
Sbjct: 961 DSEARRPCPGATGR 974
>gi|153946421 endoplasmic reticulum to nucleus signalling 1 [Homo
sapiens]
Length = 977
Score = 853 bits (2203), Expect = 0.0
Identities = 486/979 (49%), Positives = 610/979 (62%), Gaps = 84/979 (8%)
Query: 58 PWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPV 117
P RL L L LG PE LL VSTLDGSLHA+SK+TG +KWTL++DPV
Sbjct: 2 PARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPV 61
Query: 118 IEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRK 177
++ P +V E AFL DP DGSLY LG++ +GL KLPFTIPELV ASPCRSSDG+ Y G+K
Sbjct: 62 LQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKK 121
Query: 178 QDAWFVVDPESGETQMTLTTEG-----PSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRR 232
QD W+V+D +GE Q TL++ PST LY+GRT+YT+TM+D + LRWN TY
Sbjct: 122 QDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFD 181
Query: 233 YSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLP 292
Y+A + MSH S G GL++TVD SG VLW Q+ PV+ Y W ++GLR++
Sbjct: 182 YAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVM 241
Query: 293 HLTLARDTLHFLALRWGHI----RLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVS 348
H+ +A +TL +L G + + P++T ++L TLYVGK T Y S
Sbjct: 242 HINVAVETLRYLTFMSGEVGRITKWKYPFPKETEA-----KSKLTPTLYVGKYSTSLYAS 296
Query: 349 KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVA------LP 402
++VH GVA+VPRG TL +GP TD VT+ GE +PST V++ G + L
Sbjct: 297 PSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLR 356
Query: 403 SQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAF--FLELLSLSREKLWD 460
+ WLLIGHHE P T ML P E P +++ +F + L+ + E
Sbjct: 357 NYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPT 416
Query: 461 SELHPEEKTP-----------DSYLGLGPQDLLAASLTAVLLGGWILFVM-------RQQ 502
+ E+ P DS L +D+ L+ LL GW+ F++ +QQ
Sbjct: 417 TVSRDVEEKPAHAPARPEAPVDSML----KDMATIILSTFLLIGWVAFIITYPLSMHQQQ 472
Query: 503 QPQ-------------VVEKQQETPLAPADFAHISQDAQSLH--------SGAS------ 535
Q Q + ++QQ+ P P +QD + L SG S
Sbjct: 473 QLQHQQFQKELEKIQLLQQQQQQLPFHPP--GDTAQDGELLDTSGPYSESSGTSSPSTSP 530
Query: 536 RRSQKRLQSPSKQAQPLDDPEAEQ--------LTVVGKISFNPKDVLGRGAGGTFVFRGQ 587
R S L S S ++ P EQ + +VGKISF PKDVLG GA GT V+RG
Sbjct: 531 RASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGM 590
Query: 588 FEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQ 647
F+ R VAVKR+L ECF REVQLL+ESD HPNV+RYFCTE+ QF YIA+ELC A+LQ
Sbjct: 591 FDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQ 650
Query: 648 EYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLS 707
EYVE D GLEP +LQQ SGLAHLHSL+IVHRDLKP NILI+ P++ G + ++S
Sbjct: 651 EYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMIS 710
Query: 708 DFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSG 767
DFGLCKKL GR SFS SG+PGTEGW+APE+L ++PT VDIFSAGCVFYYV+S
Sbjct: 711 DFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISE 770
Query: 768 GSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHP 827
GSHPFG SL RQANIL GA L L E H+ V+AR+L+ M++ PQ RPSA VL HP
Sbjct: 771 GSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHP 830
Query: 828 FFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFR 887
FFWS KQLQFFQDVSD +EKES P+V+ LE GG AVV+ +W E+I++PLQTDLRKFR
Sbjct: 831 FFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFR 890
Query: 888 SYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRS 947
+YKG SVRDLLRA+RNKKHHYRELP EVR+ LG +PD FV YFT+RFP LL HT+RAM
Sbjct: 891 TYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMEL 950
Query: 948 CASESLFLPYY---PPDSE 963
C+ E LF PYY PP+ +
Sbjct: 951 CSHERLFQPYYFHEPPEPQ 969
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 96.7 bits (239), Expect = 1e-19
Identities = 100/324 (30%), Positives = 154/324 (47%), Gaps = 58/324 (17%)
Query: 553 DDPEAEQLTVVGKIS--FNPKDVLGRGAGGTFVFRGQFEGRAV--AVKRL-LRECFGLVR 607
++P++E+ + K+ + K+ +GRG G FV R Q +G + A K + LR R
Sbjct: 6451 NEPDSEKQSHRRKLHSFYEVKEEIGRGVFG-FVKRVQHKGNKILCAAKFIPLRS-----R 6504
Query: 608 REVQLLQESD-----RHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGL-- 660
Q +E D HP V + + LELC S +E ++ L R G+
Sbjct: 6505 TRAQAYRERDILAALSHPLVTGLLDQFETRKTLILILELC--SSEELLDR--LYRKGVVT 6560
Query: 661 --EPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAG 718
E +V +QQL+ GL +LHS ++H D+KP NIL+ P + + + DFG + +
Sbjct: 6561 EAEVKVYIQQLVEGLHYLHSHGVLHLDIKPSNILMVHPARED---IKICDFGFAQNITPA 6617
Query: 719 RCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYR 778
FS + G+ +++PE++Q P + A DI++ G + Y L+ S PF R
Sbjct: 6618 ELQFSQY----GSPEFVSPEIIQQNP---VSEASDIWAMGVISYLSLTCSS-PFAGESDR 6669
Query: 779 QA--NILTG-----APCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFF-- 829
N+L G +P AHL E+ A+D + A L PQ RPSA Q L+HP+F
Sbjct: 6670 ATLLNVLEGRVSWSSPMAAHLSED------AKDFIKATLQRAPQARPSAAQCLSHPWFLK 6723
Query: 830 --------WSRAKQLQFFQDVSDW 845
+ KQL+F S W
Sbjct: 6724 SMPAEEAHFINTKQLKFLLARSRW 6747
Score = 42.0 bits (97), Expect = 0.003
Identities = 45/169 (26%), Positives = 71/169 (42%), Gaps = 27/169 (15%)
Query: 606 VRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS--LQEYVENPDLDRGGLEPE 663
V RE + L+ RHP++ + P+ + LELC L E E +
Sbjct: 7713 VLREYEALKGL-RHPHLAQLHAAYLSPRHLVLILELCSGPELLPCLAERASYSES--EVK 7769
Query: 664 VVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRC-SF 722
L Q++S +LH+ HI+H DL+ N++IT ++ L K + G S
Sbjct: 7770 DYLWQMLSATQYLHNQHILHLDLRSENMIIT-------------EYNLLKVVDLGNAQSL 7816
Query: 723 SLHSGIPGTE-----GWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLS 766
S +P + MAPELL+ DI++ G + +LS
Sbjct: 7817 SQEKVLPSDKFKDYLETMAPELLE---GQGAVPQTDIWAIGVTAFIMLS 7862
>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
Length = 406
Score = 87.8 bits (216), Expect = 4e-17
Identities = 79/280 (28%), Positives = 131/280 (46%), Gaps = 30/280 (10%)
Query: 568 FNPKDVLGRGAGGTF---VFRGQFEGRAVAVKRL---------LRECFGLVRREVQLLQE 615
++PKDV+GRG V R AV + + L E RRE +L++
Sbjct: 24 YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQ 83
Query: 616 SDRHPNVLRYFCTERGPQFHYIALELCR-ASLQEYVENPDLDRGGLEPEVVLQQLMSGLA 674
HP+++ + F ++ +L R L +Y+ + E +++ L+ ++
Sbjct: 84 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEK-VALSEKETRSIMRSLLEAVS 142
Query: 675 HLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGW 734
LH+ +IVHRDLKP NIL+ D+ ++ LSDFG L G L GT G+
Sbjct: 143 FLHANNIVHRDLKPENILL--DDNM---QIRLSDFGFSCHLEPGEKLREL----CGTPGY 193
Query: 735 MAPELLQLLPPDSPT---SAVDIFSAGCVFYYVLSGGSHPFGD--SLYRQANILTGAPCL 789
+APE+L+ ++ VD+++ G + + +L+ GS PF + I+ G
Sbjct: 194 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQYQF 252
Query: 790 AHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFF 829
+ E + V +DL+ +L P+ R +A Q L HPFF
Sbjct: 253 SSPEWDDRSSTV-KDLISRLLQVDPEARLTAEQALQHPFF 291
>gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
Length = 387
Score = 87.8 bits (216), Expect = 4e-17
Identities = 82/283 (28%), Positives = 135/283 (47%), Gaps = 33/283 (11%)
Query: 567 SFNPKDVLGRGAGGTF---VFRGQFEGRAVAVKRL----------LRECFGLVRREVQLL 613
++ PK++LGRG + + + AV V + +RE +EV +L
Sbjct: 19 NYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDIL 78
Query: 614 QESDRHPNVLRYFCTERGPQFHYIALELC-RASLQEYVENPDLDRGGLEPEVVLQQLMSG 672
++ HPN+++ T F ++ +L R L +Y+ + E +++ L+
Sbjct: 79 RKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEK-VTLSEKETRKIMRALLEV 137
Query: 673 LAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGL-CKKLPAGRCSFSLHSGIPGT 731
+ LH L+IVHRDLKP NIL+ D+ + L+DFG C+ P R + GT
Sbjct: 138 ICTLHKLNIVHRDLKPENILL--DDNM---NIKLTDFGFSCQLEPGERL-----REVCGT 187
Query: 732 EGWMAPELLQL-LPPDSP--TSAVDIFSAGCVFYYVLSGGSHPF--GDSLYRQANILTGA 786
++APE+++ + D P VD++S G + Y +L+ GS PF + I++G
Sbjct: 188 PSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGN 246
Query: 787 PCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFF 829
E + + V +DLV L PQ R +A + LAHPFF
Sbjct: 247 YQFGSPEWDDYSDTV-KDLVSRFLVVQPQNRYTAEEALAHPFF 288
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D +QQ++ + H H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIQQILESVNHCHLNGIVHRDLKPENLLLAS-KSK 149
Query: 700 GLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGC 759
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VD+++ G
Sbjct: 150 G-AAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG- 201
Query: 760 VFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQ 815
V Y+L G PF D LY+Q I GA E + A+DL+ ML+ P
Sbjct: 202 VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWDTVTP-EAKDLINKMLTINPA 258
Query: 816 PRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A + L HP+ R+ + Q+ D L+K + + L A+
Sbjct: 259 KRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI 304
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D +QQ++ + H H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIQQILESVNHCHLNGIVHRDLKPENLLLAS-KSK 149
Query: 700 GLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGC 759
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VD+++ G
Sbjct: 150 G-AAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG- 201
Query: 760 VFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQ 815
V Y+L G PF D LY+Q I GA E + A+DL+ ML+ P
Sbjct: 202 VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWDTVTP-EAKDLINKMLTINPA 258
Query: 816 PRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A + L HP+ R+ + Q+ D L+K + + L A+
Sbjct: 259 KRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI 304
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D +QQ++ + H H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIQQILESVNHCHLNGIVHRDLKPENLLLAS-KSK 149
Query: 700 GLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGC 759
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VD+++ G
Sbjct: 150 G-AAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG- 201
Query: 760 VFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQ 815
V Y+L G PF D LY+Q I GA E + A+DL+ ML+ P
Sbjct: 202 VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWDTVTP-EAKDLINKMLTINPA 258
Query: 816 PRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A + L HP+ R+ + Q+ D L+K + + L A+
Sbjct: 259 KRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI 304
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D +QQ++ + H H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIQQILESVNHCHLNGIVHRDLKPENLLLAS-KSK 149
Query: 700 GLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGC 759
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VD+++ G
Sbjct: 150 G-AAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG- 201
Query: 760 VFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQ 815
V Y+L G PF D LY+Q I GA E + A+DL+ ML+ P
Sbjct: 202 VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWDTVTP-EAKDLINKMLTINPA 258
Query: 816 PRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A + L HP+ R+ + Q+ D L+K + + L A+
Sbjct: 259 KRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI 304
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D +QQ++ + H H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIQQILESVNHCHLNGIVHRDLKPENLLLAS-KSK 149
Query: 700 GLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGC 759
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VD+++ G
Sbjct: 150 G-AAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG- 201
Query: 760 VFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQ 815
V Y+L G PF D LY+Q I GA E + A+DL+ ML+ P
Sbjct: 202 VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWDTVTP-EAKDLINKMLTINPA 258
Query: 816 PRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A + L HP+ R+ + Q+ D L+K + + L A+
Sbjct: 259 KRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI 304
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D +QQ++ + H H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIQQILESVNHCHLNGIVHRDLKPENLLLAS-KSK 149
Query: 700 GLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGC 759
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VD+++ G
Sbjct: 150 G-AAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDMWACG- 201
Query: 760 VFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQ 815
V Y+L G PF D LY+Q I GA E + A+DL+ ML+ P
Sbjct: 202 VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWDTVTP-EAKDLINKMLTINPA 258
Query: 816 PRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A + L HP+ R+ + Q+ D L+K + + L A+
Sbjct: 259 KRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI 304
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 85.5 bits (210), Expect = 2e-16
Identities = 97/353 (27%), Positives = 154/353 (43%), Gaps = 55/353 (15%)
Query: 512 ETPLAPADFAHISQDAQSLHSGAS-RRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNP 570
ET + A I QDA S A R++ + + Q Q E + + P
Sbjct: 344 ETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ-------ENVDIATVYQIFP 396
Query: 571 KDVLGRGAGGTFVFRGQFE--GRAVAVKRLLRECF-----GLVRREVQLLQESDRHPNVL 623
+VLG G G V+ G+ GR VAVK + + F +R EV +LQ S RHP ++
Sbjct: 397 DEVLGSGQFGV-VYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQ-SLRHPGIV 454
Query: 624 RYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEV---VLQQLMSGLAHLHSLH 680
C P+ ++ +E + E + + + +G L + ++ Q++ L HLH +
Sbjct: 455 NLECMFETPEKVFVVMEKLHGDMLEMILSSE--KGRLPERLTKFLITQILVALRHLHFKN 512
Query: 681 IVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELL 740
IVH DLKP N+L+ D +V L DFG + + G SF + GT ++APE+L
Sbjct: 513 IVHCDLKPENVLLASADP--FPQVKLCDFGFARII--GEKSF--RRSVVGTPAYLAPEVL 566
Query: 741 QLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPF------GDSLYRQANILTGAPCLAHLEE 794
++D++S G + Y LS G+ PF D + A + +P
Sbjct: 567 L---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNEDEDINDQIQNAAFMYPASPW------ 616
Query: 795 EVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLE 847
H A DL+ +L + R S + L+HP + Q+ WL+
Sbjct: 617 -SHISAGAIDLINNLLQVKMRKRYSVDKSLSHP----------WLQEYQTWLD 658
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 85.5 bits (210), Expect = 2e-16
Identities = 97/353 (27%), Positives = 154/353 (43%), Gaps = 55/353 (15%)
Query: 512 ETPLAPADFAHISQDAQSLHSGAS-RRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNP 570
ET + A I QDA S A R++ + + Q Q E + + P
Sbjct: 501 ETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ-------ENVDIATVYQIFP 553
Query: 571 KDVLGRGAGGTFVFRGQFE--GRAVAVKRLLRECF-----GLVRREVQLLQESDRHPNVL 623
+VLG G G V+ G+ GR VAVK + + F +R EV +LQ S RHP ++
Sbjct: 554 DEVLGSGQFGV-VYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQ-SLRHPGIV 611
Query: 624 RYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEV---VLQQLMSGLAHLHSLH 680
C P+ ++ +E + E + + + +G L + ++ Q++ L HLH +
Sbjct: 612 NLECMFETPEKVFVVMEKLHGDMLEMILSSE--KGRLPERLTKFLITQILVALRHLHFKN 669
Query: 681 IVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELL 740
IVH DLKP N+L+ D +V L DFG + + G SF + GT ++APE+L
Sbjct: 670 IVHCDLKPENVLLASADP--FPQVKLCDFGFARII--GEKSF--RRSVVGTPAYLAPEVL 723
Query: 741 QLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPF------GDSLYRQANILTGAPCLAHLEE 794
++D++S G + Y LS G+ PF D + A + +P
Sbjct: 724 L---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNEDEDINDQIQNAAFMYPASPW------ 773
Query: 795 EVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLE 847
H A DL+ +L + R S + L+HP + Q+ WL+
Sbjct: 774 -SHISAGAIDLINNLLQVKMRKRYSVDKSLSHP----------WLQEYQTWLD 815
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 85.5 bits (210), Expect = 2e-16
Identities = 97/353 (27%), Positives = 154/353 (43%), Gaps = 55/353 (15%)
Query: 512 ETPLAPADFAHISQDAQSLHSGAS-RRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNP 570
ET + A I QDA S A R++ + + Q Q E + + P
Sbjct: 501 ETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ-------ENVDIATVYQIFP 553
Query: 571 KDVLGRGAGGTFVFRGQFE--GRAVAVKRLLRECF-----GLVRREVQLLQESDRHPNVL 623
+VLG G G V+ G+ GR VAVK + + F +R EV +LQ S RHP ++
Sbjct: 554 DEVLGSGQFGV-VYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQ-SLRHPGIV 611
Query: 624 RYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEV---VLQQLMSGLAHLHSLH 680
C P+ ++ +E + E + + + +G L + ++ Q++ L HLH +
Sbjct: 612 NLECMFETPEKVFVVMEKLHGDMLEMILSSE--KGRLPERLTKFLITQILVALRHLHFKN 669
Query: 681 IVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELL 740
IVH DLKP N+L+ D +V L DFG + + G SF + GT ++APE+L
Sbjct: 670 IVHCDLKPENVLLASADP--FPQVKLCDFGFARII--GEKSF--RRSVVGTPAYLAPEVL 723
Query: 741 QLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPF------GDSLYRQANILTGAPCLAHLEE 794
++D++S G + Y LS G+ PF D + A + +P
Sbjct: 724 L---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNEDEDINDQIQNAAFMYPASPW------ 773
Query: 795 EVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLE 847
H A DL+ +L + R S + L+HP + Q+ WL+
Sbjct: 774 -SHISAGAIDLINNLLQVKMRKRYSVDKSLSHP----------WLQEYQTWLD 815
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 85.5 bits (210), Expect = 2e-16
Identities = 97/353 (27%), Positives = 154/353 (43%), Gaps = 55/353 (15%)
Query: 512 ETPLAPADFAHISQDAQSLHSGAS-RRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNP 570
ET + A I QDA S A R++ + + Q Q E + + P
Sbjct: 501 ETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ-------ENVDIATVYQIFP 553
Query: 571 KDVLGRGAGGTFVFRGQFE--GRAVAVKRLLRECF-----GLVRREVQLLQESDRHPNVL 623
+VLG G G V+ G+ GR VAVK + + F +R EV +LQ S RHP ++
Sbjct: 554 DEVLGSGQFGV-VYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQ-SLRHPGIV 611
Query: 624 RYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEV---VLQQLMSGLAHLHSLH 680
C P+ ++ +E + E + + + +G L + ++ Q++ L HLH +
Sbjct: 612 NLECMFETPEKVFVVMEKLHGDMLEMILSSE--KGRLPERLTKFLITQILVALRHLHFKN 669
Query: 681 IVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELL 740
IVH DLKP N+L+ D +V L DFG + + G SF + GT ++APE+L
Sbjct: 670 IVHCDLKPENVLLASADP--FPQVKLCDFGFARII--GEKSF--RRSVVGTPAYLAPEVL 723
Query: 741 QLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPF------GDSLYRQANILTGAPCLAHLEE 794
++D++S G + Y LS G+ PF D + A + +P
Sbjct: 724 L---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNEDEDINDQIQNAAFMYPASPW------ 773
Query: 795 EVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLE 847
H A DL+ +L + R S + L+HP + Q+ WL+
Sbjct: 774 -SHISAGAIDLINNLLQVKMRKRYSVDKSLSHP----------WLQEYQTWLD 815
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 84.0 bits (206), Expect = 6e-16
Identities = 91/310 (29%), Positives = 142/310 (45%), Gaps = 42/310 (13%)
Query: 533 GASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRA 592
G R R+ + + Q L E ++ V +I ++ LG GA V Q G A
Sbjct: 67 GGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEI----RERLGSGAFSEVVL-AQERGSA 121
Query: 593 VAV------KRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASL 646
V K+ LR LV E+ +L+ HPN++ P Y+A+EL
Sbjct: 122 HLVALKCIPKKALRGKEALVENEIAVLRRIS-HPNIVALEDVHESPSHLYLAMELVTGG- 179
Query: 647 QEYVENPDLDRGGL---EPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGR 703
+ + ++RG + ++ Q++ +++LHSL IVHRDLKP N+L P +
Sbjct: 180 --ELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFED--SK 235
Query: 704 VVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYY 763
+++SDFGL K+ AG ++ GT G++APELL+ P AVD+++ G V Y
Sbjct: 236 IMVSDFGL-SKIQAG----NMLGTACGTPGYVAPELLEQKPYG---KAVDVWALG-VISY 286
Query: 764 VLSGGSHPFGD-------SLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQP 816
+L G PF D S +A+ +P + E A+D + +L PQ
Sbjct: 287 ILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISES------AKDFIRHLLERDPQK 340
Query: 817 RPSAPQVLAH 826
R + Q L H
Sbjct: 341 RFTCQQALRH 350
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 83.6 bits (205), Expect = 8e-16
Identities = 96/323 (29%), Positives = 141/323 (43%), Gaps = 48/323 (14%)
Query: 536 RRSQKRLQSPSKQAQP------LDDPEAEQLTVV-----GKISFNPKD--------VLGR 576
R Q+ +P+ A P L PE E L + G++ +P+ +LG+
Sbjct: 11 RPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGK 70
Query: 577 GAGGTFVFRGQFE-GRAVAVKRLLRECFGLVRREVQLLQESD-----RHPNVLRYFCTER 630
G E G A AVK + + + ++L E + +H +++R+
Sbjct: 71 GGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFE 130
Query: 631 GPQFHYIALELCRASLQEYVENPDLDRGGLEPEV--VLQQLMSGLAHLHSLHIVHRDLKP 688
YI LELC ++ LEPEV L+Q++SGL +LH I+HRDLK
Sbjct: 131 DADNIYIFLELCSRKSLAHIWKARHTL--LEPEVRYYLRQILSGLKYLHQRGILHRDLKL 188
Query: 689 GNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSP 748
GN IT +G DFGL +L I GT ++APE+L L P
Sbjct: 189 GNFFITENMELKVG-----DFGLAARLEPPE---QRKKTICGTPNYVAPEVL-LRQGHGP 239
Query: 749 TSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCL--AHLEEEVHDKVVARDLV 806
+ D++S GCV Y +L GS PF A++ C+ H + AR L+
Sbjct: 240 EA--DVWSLGCVMYTLLC-GSPPF-----ETADLKETYRCIKQVHYTLPASLSLPARQLL 291
Query: 807 GAMLSPLPQPRPSAPQVLAHPFF 829
A+L P+ RPS Q+L H FF
Sbjct: 292 AAILRASPRDRPSIDQILRHDFF 314
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 83.2 bits (204), Expect = 1e-15
Identities = 85/304 (27%), Positives = 147/304 (48%), Gaps = 26/304 (8%)
Query: 545 PSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFE--GRAVAVKRLLREC 602
P +Q + LD+ + LT + F+ + LG G+ G+ V++ + G+ VA+K++ E
Sbjct: 10 PRRQLKKLDE---DSLTKQPEEVFDVLEKLGEGSYGS-VYKAIHKETGQIVAIKQVPVES 65
Query: 603 -FGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRA-SLQEYVENPDLDRGGL 660
+ +E+ ++Q+ D P+V++Y+ + +I +E C A S+ + + +
Sbjct: 66 DLQEIIKEISIMQQCDS-PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTED 124
Query: 661 EPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRC 720
E +LQ + GL +LH + +HRD+K GNIL+ G L+DFG+ +L
Sbjct: 125 EIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE-----GHAKLADFGVAGQLTD--- 176
Query: 721 SFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQA 780
+ + + + GT WMAPE++Q + DI+S G + ++ G P+ D +A
Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEI---GYNCVADIWSLG-ITAIEMAEGKPPYADIHPMRA 232
Query: 781 --NILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQF 838
I T P E D D V L P+ R +A Q+L HPF S AK +
Sbjct: 233 IFMIPTNPPPTFRKPELWSDNFT--DFVKQCLVKSPEQRATATQLLQHPFVRS-AKGVSI 289
Query: 839 FQDV 842
+D+
Sbjct: 290 LRDL 293
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 82.8 bits (203), Expect = 1e-15
Identities = 82/305 (26%), Positives = 135/305 (44%), Gaps = 69/305 (22%)
Query: 570 PKDVLGRGAGGTFVFRGQFE--GRAVAVKRLLRECF-----GLVRREVQLLQESDRHPNV 622
P +VLG G G V+ G+ GR VA+K + + F +R EV +LQ HP V
Sbjct: 585 PDEVLGSGQFG-IVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNL-HHPGV 642
Query: 623 LRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEV---VLQQLMSGLAHLHSL 679
+ C P+ ++ +E + E + + + +G L + ++ Q++ L HLH
Sbjct: 643 VNLECMFETPERVFVVMEKLHGDMLEMILSSE--KGRLPEHITKFLITQILVALRHLHFK 700
Query: 680 HIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPEL 739
+IVH DLKP N+L+ D +V L DFG + + G SF + GT ++APE+
Sbjct: 701 NIVHCDLKPENVLLASADP--FPQVKLCDFGFARII--GEKSF--RRSVVGTPAYLAPEV 754
Query: 740 LQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDK 799
L+ ++D++S G + Y LS G+ PF + +E++HD+
Sbjct: 755 LR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFNE------------------DEDIHDQ 792
Query: 800 V-----------------VARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDV 842
+ A DL+ +L + R S + L+HP + QD
Sbjct: 793 IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHP----------WLQDY 842
Query: 843 SDWLE 847
WL+
Sbjct: 843 QTWLD 847
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 82.8 bits (203), Expect = 1e-15
Identities = 86/306 (28%), Positives = 140/306 (45%), Gaps = 41/306 (13%)
Query: 574 LGRGAGGTF-----VFRGQ-FEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFC 627
LG+GA V GQ + + + K+L + RE ++ + +HPN++R
Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHD 77
Query: 628 TERGPQFHYIALELCRAS-------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLH 680
+ HY+ +L +EY D +QQ++ + H H +
Sbjct: 78 SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASH-------CIQQILEAVLHCHQMG 130
Query: 681 IVHRDLKPGNILITGPDSQGLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPEL 739
+VHRDLKP N+L+ S+ G V L+DFGL ++ + ++ G GT G+++PE+
Sbjct: 131 VVHRDLKPENLLLA---SKLKGAAVKLADFGLAIEVEGEQQAW---FGFAGTPGYLSPEV 184
Query: 740 LQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEE 795
L+ P P VD+++ G V Y+L G PF D LY+Q I GA E +
Sbjct: 185 LRKDPYGKP---VDLWACG-VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWD 238
Query: 796 VHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQE 853
A+DL+ ML+ P R +A + L HP+ R+ Q+ D L+K + +
Sbjct: 239 TVTP-EAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 297
Query: 854 PLVRAL 859
L A+
Sbjct: 298 KLKGAI 303
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 82.8 bits (203), Expect = 1e-15
Identities = 86/306 (28%), Positives = 140/306 (45%), Gaps = 41/306 (13%)
Query: 574 LGRGAGGTF-----VFRGQ-FEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFC 627
LG+GA V GQ + + + K+L + RE ++ + +HPN++R
Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHD 77
Query: 628 TERGPQFHYIALELCRAS-------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLH 680
+ HY+ +L +EY D +QQ++ + H H +
Sbjct: 78 SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASH-------CIQQILEAVLHCHQMG 130
Query: 681 IVHRDLKPGNILITGPDSQGLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPEL 739
+VHRDLKP N+L+ S+ G V L+DFGL ++ + ++ G GT G+++PE+
Sbjct: 131 VVHRDLKPENLLLA---SKLKGAAVKLADFGLAIEVEGEQQAW---FGFAGTPGYLSPEV 184
Query: 740 LQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDS----LYRQANILTGAPCLAHLEEE 795
L+ P P VD+++ G V Y+L G PF D LY+Q I GA E +
Sbjct: 185 LRKDPYGKP---VDLWACG-VILYILLVGYPPFWDEDQHRLYQQ--IKAGAYDFPSPEWD 238
Query: 796 VHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQE 853
A+DL+ ML+ P R +A + L HP+ R+ Q+ D L+K + +
Sbjct: 239 TVTP-EAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARR 297
Query: 854 PLVRAL 859
L A+
Sbjct: 298 KLKGAI 303
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/287 (27%), Positives = 133/287 (46%), Gaps = 35/287 (12%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D + Q++ + H+H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIHQILESVNHIHQHDIVHRDLKPENLLLA---SK 147
Query: 700 GLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAG 758
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VDI++ G
Sbjct: 148 CKGAAVKLADFGLAIEVQGEQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG 201
Query: 759 CVFYYVLSGGSHPFGD----SLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLP 814
V Y+L G PF D LY+Q I GA E + A++L+ ML+ P
Sbjct: 202 -VILYILLVGYPPFWDEDQHKLYQQ--IKAGAYDFPSPEWDTVTP-EAKNLINQMLTINP 257
Query: 815 QPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A Q L HP+ R+ + Q+ + L K + + L A+
Sbjct: 258 AKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAI 304
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/287 (27%), Positives = 133/287 (46%), Gaps = 35/287 (12%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D + Q++ + H+H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIHQILESVNHIHQHDIVHRDLKPENLLLA---SK 147
Query: 700 GLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAG 758
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VDI++ G
Sbjct: 148 CKGAAVKLADFGLAIEVQGEQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG 201
Query: 759 CVFYYVLSGGSHPFGD----SLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLP 814
V Y+L G PF D LY+Q I GA E + A++L+ ML+ P
Sbjct: 202 -VILYILLVGYPPFWDEDQHKLYQQ--IKAGAYDFPSPEWDTVTP-EAKNLINQMLTINP 257
Query: 815 QPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A Q L HP+ R+ + Q+ + L K + + L A+
Sbjct: 258 AKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAI 304
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/287 (27%), Positives = 133/287 (46%), Gaps = 35/287 (12%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D + Q++ + H+H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIHQILESVNHIHQHDIVHRDLKPENLLLA---SK 147
Query: 700 GLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAG 758
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VDI++ G
Sbjct: 148 CKGAAVKLADFGLAIEVQGEQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG 201
Query: 759 CVFYYVLSGGSHPFGD----SLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLP 814
V Y+L G PF D LY+Q I GA E + A++L+ ML+ P
Sbjct: 202 -VILYILLVGYPPFWDEDQHKLYQQ--IKAGAYDFPSPEWDTVTP-EAKNLINQMLTINP 257
Query: 815 QPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A Q L HP+ R+ + Q+ + L K + + L A+
Sbjct: 258 AKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAI 304
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/287 (27%), Positives = 133/287 (46%), Gaps = 35/287 (12%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D + Q++ + H+H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIHQILESVNHIHQHDIVHRDLKPENLLLA---SK 147
Query: 700 GLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAG 758
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VDI++ G
Sbjct: 148 CKGAAVKLADFGLAIEVQGEQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG 201
Query: 759 CVFYYVLSGGSHPFGD----SLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLP 814
V Y+L G PF D LY+Q I GA E + A++L+ ML+ P
Sbjct: 202 -VILYILLVGYPPFWDEDQHKLYQQ--IKAGAYDFPSPEWDTVTP-EAKNLINQMLTINP 257
Query: 815 QPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A Q L HP+ R+ + Q+ + L K + + L A+
Sbjct: 258 AKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAI 304
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/287 (27%), Positives = 133/287 (46%), Gaps = 35/287 (12%)
Query: 587 QFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRAS- 645
++ + + K+L + RE ++ + +HPN++R + FHY+ +L
Sbjct: 39 EYAAKIINTKKLSARDHQKLEREARICRLL-KHPNIVRLHDSISEEGFHYLVFDLVTGGE 97
Query: 646 ------LQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQ 699
+EY D + Q++ + H+H IVHRDLKP N+L+ S+
Sbjct: 98 LFEDIVAREYYSEADASH-------CIHQILESVNHIHQHDIVHRDLKPENLLLA---SK 147
Query: 700 GLGRVV-LSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAG 758
G V L+DFGL ++ + ++ G GT G+++PE+L+ P P VDI++ G
Sbjct: 148 CKGAAVKLADFGLAIEVQGEQQAW---FGFAGTPGYLSPEVLRKDPYGKP---VDIWACG 201
Query: 759 CVFYYVLSGGSHPFGD----SLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLP 814
V Y+L G PF D LY+Q I GA E + A++L+ ML+ P
Sbjct: 202 -VILYILLVGYPPFWDEDQHKLYQQ--IKAGAYDFPSPEWDTVTP-EAKNLINQMLTINP 257
Query: 815 QPRPSAPQVLAHPFFWSRA--KQLQFFQDVSDWLEKESEQEPLVRAL 859
R +A Q L HP+ R+ + Q+ + L K + + L A+
Sbjct: 258 AKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAI 304
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 82.0 bits (201), Expect = 2e-15
Identities = 83/272 (30%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 571 KDVLGRGAGGTFVFRGQFEGRAVAV------KRLLRECFGLVRREVQLLQESDRHPNVLR 624
++ LG GA V Q G A V K+ LR LV E+ +L+ HPN++
Sbjct: 35 RERLGSGAFSEVVL-AQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS-HPNIVA 92
Query: 625 YFCTERGPQFHYIALELCRASLQEYVENPDLDRGGL---EPEVVLQQLMSGLAHLHSLHI 681
P Y+A+EL + + ++RG + ++ Q++ +++LHSL I
Sbjct: 93 LEDVHESPSHLYLAMELVTGG---ELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 149
Query: 682 VHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQ 741
VHRDLKP N+L P ++++SDFGL K+ AG ++ GT G++APELL+
Sbjct: 150 VHRDLKPENLLYATPFED--SKIMVSDFGL-SKIQAG----NMLGTACGTPGYVAPELLE 202
Query: 742 LLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGD-------SLYRQANILTGAPCLAHLEE 794
P AVD+++ G V Y+L G PF D S +A+ +P + E
Sbjct: 203 QKPYG---KAVDVWALG-VISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 258
Query: 795 EVHDKVVARDLVGAMLSPLPQPRPSAPQVLAH 826
A+D + +L PQ R + Q L H
Sbjct: 259 S------AKDFIRHLLERDPQKRFTCQQALRH 284
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 82.0 bits (201), Expect = 2e-15
Identities = 80/295 (27%), Positives = 127/295 (43%), Gaps = 34/295 (11%)
Query: 548 QAQPLDDPEAEQLTVVGKIS--FNPKDVLGRGAGGTFVF-RGQFEGRAVAVKRLL----- 599
+A L DP+ +L F+ +G G+ G F R VA+K++
Sbjct: 6 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65
Query: 600 -RECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRG 658
E + + +EV+ LQ+ RHPN ++Y ++ +E C S + +E
Sbjct: 66 SNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQ 124
Query: 659 GLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKL-PA 717
+E V + GLA+LHS +++HRD+K GNIL++ P G V L DFG + PA
Sbjct: 125 EVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEP-----GLVKLGDFGSASIMAPA 179
Query: 718 GRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLY 777
+ GT WMAPE++ + VD++S G + F
Sbjct: 180 --------NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF----- 226
Query: 778 RQANILTGAPCLAHLEEEV----HDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF 828
N ++ +A E V H R+ V + L +PQ RP++ +L H F
Sbjct: 227 -NMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 280
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 82.0 bits (201), Expect = 2e-15
Identities = 80/295 (27%), Positives = 127/295 (43%), Gaps = 34/295 (11%)
Query: 548 QAQPLDDPEAEQLTVVGKIS--FNPKDVLGRGAGGTFVF-RGQFEGRAVAVKRLL----- 599
+A L DP+ +L F+ +G G+ G F R VA+K++
Sbjct: 6 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65
Query: 600 -RECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRG 658
E + + +EV+ LQ+ RHPN ++Y ++ +E C S + +E
Sbjct: 66 SNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQ 124
Query: 659 GLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKL-PA 717
+E V + GLA+LHS +++HRD+K GNIL++ P G V L DFG + PA
Sbjct: 125 EVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEP-----GLVKLGDFGSASIMAPA 179
Query: 718 GRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLY 777
+ GT WMAPE++ + VD++S G + F
Sbjct: 180 --------NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF----- 226
Query: 778 RQANILTGAPCLAHLEEEV----HDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF 828
N ++ +A E V H R+ V + L +PQ RP++ +L H F
Sbjct: 227 -NMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 280
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 81.6 bits (200), Expect = 3e-15
Identities = 72/269 (26%), Positives = 128/269 (47%), Gaps = 24/269 (8%)
Query: 568 FNPKDVLGRGA-GGTFVFRGQFEGRAVAVKRLLRECF---GLVRR---EVQLLQESDRHP 620
F ++LG+G+ G + G VA+K + ++ G+V+R EV++ + +HP
Sbjct: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL-KHP 70
Query: 621 NVLRYFCTERGPQFHYIALELCR-ASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSL 679
++L + + Y+ LE+C + Y++N E + Q+++G+ +LHS
Sbjct: 71 SILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSH 130
Query: 680 HIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPEL 739
I+HRDL N+L+T + + ++DFGL +L + H + GT +++PE
Sbjct: 131 GILHRDLTLSNLLLTRNMN-----IKIADFGLATQL---KMPHEKHYTLCGTPNYISPE- 181
Query: 740 LQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDK 799
+ + D++S GC+FY +L G D++ N + LA E
Sbjct: 182 --IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----LADYEMPSFLS 235
Query: 800 VVARDLVGAMLSPLPQPRPSAPQVLAHPF 828
+ A+DL+ +L P R S VL HPF
Sbjct: 236 IEAKDLIHQLLRRNPADRLSLSSVLDHPF 264
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,933,554
Number of Sequences: 37866
Number of extensions: 2313616
Number of successful extensions: 10730
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 458
Number of HSP's successfully gapped in prelim test: 372
Number of HSP's that attempted gapping in prelim test: 8687
Number of HSP's gapped (non-prelim): 1889
length of query: 974
length of database: 18,247,518
effective HSP length: 112
effective length of query: 862
effective length of database: 14,006,526
effective search space: 12073625412
effective search space used: 12073625412
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.