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Search of human proteins with 145309324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145309324 FH2 domain containing 1 [Homo sapiens]
(1143 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145309324 FH2 domain containing 1 [Homo sapiens] 2293 0.0
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 236 1e-61
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 236 1e-61
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 197 5e-50
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 197 5e-50
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 187 5e-47
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 187 6e-47
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 179 1e-44
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 177 7e-44
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 175 2e-43
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 173 1e-42
gi|52485606 formin-like 2 [Homo sapiens] 168 2e-41
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 166 2e-40
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 166 2e-40
gi|33356148 formin-like 1 [Homo sapiens] 154 6e-37
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 153 1e-36
gi|157168329 formin 1 [Homo sapiens] 152 2e-36
gi|160707881 formin 2 [Homo sapiens] 114 7e-25
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 107 5e-23
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 83 2e-15
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 76 2e-13
gi|169163027 PREDICTED: similar to Putative acrosin-like proteas... 69 2e-11
gi|56549694 enabled homolog isoform a [Homo sapiens] 69 3e-11
gi|39930375 enabled homolog isoform b [Homo sapiens] 69 3e-11
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 69 3e-11
gi|210032580 SET domain containing 1B [Homo sapiens] 68 6e-11
gi|11386183 WAS protein family, member 2 [Homo sapiens] 67 7e-11
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 67 1e-10
gi|148613878 acrosin precursor [Homo sapiens] 67 1e-10
gi|153792074 proline rich 12 [Homo sapiens] 66 2e-10
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 2293 bits (5942), Expect = 0.0
Identities = 1143/1143 (100%), Positives = 1143/1143 (100%)
Query: 1 MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPP 60
MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPP
Sbjct: 1 MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPP 60
Query: 61 PPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLA 120
PPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLA
Sbjct: 61 PPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLA 120
Query: 121 ARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGI 180
ARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGI
Sbjct: 121 ARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGI 180
Query: 181 FLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADS 240
FLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADS
Sbjct: 181 FLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADS 240
Query: 241 FLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQ 300
FLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQ
Sbjct: 241 FLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQ 300
Query: 301 AGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLH 360
AGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLH
Sbjct: 301 AGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLH 360
Query: 361 HVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQ 420
HVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQ
Sbjct: 361 HVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQ 420
Query: 421 ELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQ 480
ELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQ
Sbjct: 421 ELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQ 480
Query: 481 EQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRSR 540
EQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRSR
Sbjct: 481 EQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRSR 540
Query: 541 LSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAH 600
LSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAH
Sbjct: 541 LSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAH 600
Query: 601 KPQASGGQEEAPNPPSAQAHQLAAAQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQS 660
KPQASGGQEEAPNPPSAQAHQLAAAQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQS
Sbjct: 601 KPQASGGQEEAPNPPSAQAHQLAAAQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQS 660
Query: 661 PPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSAS 720
PPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSAS
Sbjct: 661 PPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSAS 720
Query: 721 SSSLTPMGRDALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCS 780
SSSLTPMGRDALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCS
Sbjct: 721 SSSLTPMGRDALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCS 780
Query: 781 LTLDCSEGTDSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDS 840
LTLDCSEGTDSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDS
Sbjct: 781 LTLDCSEGTDSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDS 840
Query: 841 EPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENE 900
EPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENE
Sbjct: 841 EPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENE 900
Query: 901 SMRKVMPITKSSRGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRG 960
SMRKVMPITKSSRGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRG
Sbjct: 901 SMRKVMPITKSSRGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRG 960
Query: 961 SSGSSSTRPGRDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTP 1020
SSGSSSTRPGRDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTP
Sbjct: 961 SSGSSSTRPGRDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTP 1020
Query: 1021 SVPSVPHELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAP 1080
SVPSVPHELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAP
Sbjct: 1021 SVPSVPHELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAP 1080
Query: 1081 KDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNP 1140
KDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNP
Sbjct: 1081 KDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNP 1140
Query: 1141 LRK 1143
LRK
Sbjct: 1141 LRK 1143
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 236 bits (601), Expect = 1e-61
Identities = 158/520 (30%), Positives = 249/520 (47%), Gaps = 70/520 (13%)
Query: 30 PPPAPPPPP------------PPPPPSPPCSCSREECPSSPPP---------PPPPPLPG 68
PPP PPPPP PPPPP P P PPP PPPPPLPG
Sbjct: 437 PPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPG 496
Query: 69 ------EPPI--------PPPPPGLPPTT------------------HMNGYSHLGKKKR 96
PP+ PPPPP L P T H G + + +R
Sbjct: 497 LGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRR 556
Query: 97 -------MRSFFWKTIPEEQVRGKTNIW-TLAARQEHHYQIDTKTIEELFGQQEDTTKSS 148
M+ W+ +P R ++W +L++ + D +IE LF + ++
Sbjct: 557 VNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLF-----SFPAA 611
Query: 149 LPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSET 208
P+ + R+ +EIT LDAK+S+N+ IFLKQFK S + I G + + E
Sbjct: 612 KPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEV 671
Query: 209 LREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSC 268
L++ LK LPE E++ L+AF+ + +KL+ AD F L+ +P Y LRIE M+L +
Sbjct: 672 LKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVL 731
Query: 269 SSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADT 328
+ ++ A + L++ +L L+L+ GN +N G + G+A GFK+S+LLKL +T
Sbjct: 732 DMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTET 791
Query: 329 KANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLK 388
K+ + + LLH V +EA+K LL L + A ++LE +E + +
Sbjct: 792 KSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETE 851
Query: 389 ENIQRD-GELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQ 447
+ E+ +Q + LQ +I R L+ + ++ + L D+ CED + + L++ F
Sbjct: 852 RKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFS 911
Query: 448 IFRDFCTKFNKAVKDNHDREAQEL---RQLQRLKEQEQKQ 484
+ F F +A+K+N DR+ Q R+ Q+L E+E ++
Sbjct: 912 TMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARR 951
Score = 64.7 bits (156), Expect = 5e-10
Identities = 33/64 (51%), Positives = 35/64 (54%), Gaps = 14/64 (21%)
Query: 29 TPPPAPPPP--------PPPPPPSPPCSCSREECPSSPPPPPPPPLPG----EPPIPPPP 76
TPPP PPPP PPPPPP PP + + P PPPPPLPG PP PP P
Sbjct: 420 TPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAK--ALPTAPPPPPLPGLGAMAPPAPPLP 477
Query: 77 PGLP 80
P LP
Sbjct: 478 PPLP 481
Score = 48.9 bits (115), Expect = 3e-05
Identities = 23/33 (69%), Positives = 25/33 (75%), Gaps = 4/33 (12%)
Query: 52 EECPSSPPPPPPPP-LPG---EPPIPPPPPGLP 80
E+ S+PPPPPPPP LPG EPP PPPPP LP
Sbjct: 415 EQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLP 447
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 236 bits (601), Expect = 1e-61
Identities = 158/520 (30%), Positives = 249/520 (47%), Gaps = 70/520 (13%)
Query: 30 PPPAPPPPP------------PPPPPSPPCSCSREECPSSPPP---------PPPPPLPG 68
PPP PPPPP PPPPP P P PPP PPPPPLPG
Sbjct: 437 PPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPG 496
Query: 69 ------EPPI--------PPPPPGLPPTT------------------HMNGYSHLGKKKR 96
PP+ PPPPP L P T H G + + +R
Sbjct: 497 LGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRR 556
Query: 97 -------MRSFFWKTIPEEQVRGKTNIW-TLAARQEHHYQIDTKTIEELFGQQEDTTKSS 148
M+ W+ +P R ++W +L++ + D +IE LF + ++
Sbjct: 557 VNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLF-----SFPAA 611
Query: 149 LPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSET 208
P+ + R+ +EIT LDAK+S+N+ IFLKQFK S + I G + + E
Sbjct: 612 KPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEV 671
Query: 209 LREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSC 268
L++ LK LPE E++ L+AF+ + +KL+ AD F L+ +P Y LRIE M+L +
Sbjct: 672 LKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVL 731
Query: 269 SSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADT 328
+ ++ A + L++ +L L+L+ GN +N G + G+A GFK+S+LLKL +T
Sbjct: 732 DMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTET 791
Query: 329 KANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLK 388
K+ + + LLH V +EA+K LL L + A ++LE +E + +
Sbjct: 792 KSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETE 851
Query: 389 ENIQRD-GELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQ 447
+ E+ +Q + LQ +I R L+ + ++ + L D+ CED + + L++ F
Sbjct: 852 RKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFS 911
Query: 448 IFRDFCTKFNKAVKDNHDREAQEL---RQLQRLKEQEQKQ 484
+ F F +A+K+N DR+ Q R+ Q+L E+E ++
Sbjct: 912 TMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARR 951
Score = 64.7 bits (156), Expect = 5e-10
Identities = 33/64 (51%), Positives = 35/64 (54%), Gaps = 14/64 (21%)
Query: 29 TPPPAPPPP--------PPPPPPSPPCSCSREECPSSPPPPPPPPLPG----EPPIPPPP 76
TPPP PPPP PPPPPP PP + + P PPPPPLPG PP PP P
Sbjct: 420 TPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAK--ALPTAPPPPPLPGLGAMAPPAPPLP 477
Query: 77 PGLP 80
P LP
Sbjct: 478 PPLP 481
Score = 48.9 bits (115), Expect = 3e-05
Identities = 23/33 (69%), Positives = 25/33 (75%), Gaps = 4/33 (12%)
Query: 52 EECPSSPPPPPPPP-LPG---EPPIPPPPPGLP 80
E+ S+PPPPPPPP LPG EPP PPPPP LP
Sbjct: 415 EQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLP 447
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 197 bits (501), Expect = 5e-50
Identities = 143/512 (27%), Positives = 231/512 (45%), Gaps = 47/512 (9%)
Query: 19 ATAPGFMIGQTPPPAP-----PPPPPP-------PPPSPPCSCSREECPSSPPP------ 60
++ PG PPP P PPPPPP PPP PP P PPP
Sbjct: 658 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLP-GEAGMPPPPPPLPGGPG 716
Query: 61 -PPPPPLPGEPPIPPPPPGL---PPTTHMNGYSH-------LGKKK------RMRSFFWK 103
PPPPP PG P IPPPPPG+ PP G L KK ++R W
Sbjct: 717 IPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWS 776
Query: 104 TIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREA 163
+ E + + WT + F Q T+K+ + G S ++
Sbjct: 777 KLVAEDL-SQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKK 835
Query: 164 R-EEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEV 222
+ +E+ +LD+K + N+ IFL F+ + I I + ++ +K +PE E++
Sbjct: 836 KVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQL 895
Query: 223 KKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAI 282
K L + L+ ++ F + VP R+ A++ K +F ++ +I + A
Sbjct: 896 KMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAAC 955
Query: 283 KELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVA 342
+EL E ++L + L GN MNAG A GF +S L KL DTK+ M LLHF+A
Sbjct: 956 EELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLA 1015
Query: 343 QEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQ-------RDG 395
+ + +L F ++L HV+K +R+S EN + L + + ++ ++Q
Sbjct: 1016 ELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKD 1075
Query: 396 ELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTK 455
+ ++M F++ A E+ +L ++ L ++F D K + ++E F +F
Sbjct: 1076 KFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNM 1135
Query: 456 FNKAVKDNHDREAQE--LRQLQRLKEQEQKQR 485
F +AVK+N R E +R+ + KE+ +K+R
Sbjct: 1136 FLQAVKENQKRRETEEKMRRAKLAKEKAEKER 1167
Score = 67.0 bits (162), Expect = 1e-10
Identities = 30/63 (47%), Positives = 34/63 (53%), Gaps = 5/63 (7%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPP-----GLPPTTH 84
PPP PPPPPPPP P C S P PPPPL G+ IPPPPP G+P +
Sbjct: 600 PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSS 659
Query: 85 MNG 87
+ G
Sbjct: 660 LPG 662
Score = 66.6 bits (161), Expect = 1e-10
Identities = 39/105 (37%), Positives = 42/105 (40%), Gaps = 38/105 (36%)
Query: 14 ENGNIATAPGFMIGQTPPPAPPPPPPPPPP-------------------SPPCSCSREEC 54
++G I P T PP PPPPPPPPPP SPP S +
Sbjct: 582 DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT 641
Query: 55 PSSPPP-------------------PPPPPLPGEPPIPPPPPGLP 80
PPP PPPPPLPG IPPPPP LP
Sbjct: 642 IPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLP 686
Score = 53.5 bits (127), Expect = 1e-06
Identities = 34/76 (44%), Positives = 38/76 (50%), Gaps = 20/76 (26%)
Query: 20 TAPGFMIGQTP-PPAPPPPPP-----PPPPSPPCSCSREECPSSPPPPPPPPLPG----- 68
T P + + P PPAPP P PPPP+P S + P PPPPPPPPLPG
Sbjct: 562 TVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP--PPPPPPPPPPPLPGGVCIS 619
Query: 69 EPP-------IPPPPP 77
PP I PPPP
Sbjct: 620 SPPSLPGGTAISPPPP 635
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 13 KENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPI 72
KE +++ A + P AP PP PP P P PPPPP P PP
Sbjct: 551 KEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP--PPP 608
Query: 73 PPPPPG 78
PPP PG
Sbjct: 609 PPPLPG 614
Score = 45.1 bits (105), Expect = 4e-04
Identities = 25/50 (50%), Positives = 27/50 (54%), Gaps = 13/50 (26%)
Query: 42 PPSPPCSCSREECPSSPPPP-------PPPPLPGE---PPIPPPPPGLPP 81
PPS P SR P +PP P PPPP PG+ PP PPPPP PP
Sbjct: 564 PPSVP---SRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPP 610
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 197 bits (501), Expect = 5e-50
Identities = 143/512 (27%), Positives = 231/512 (45%), Gaps = 47/512 (9%)
Query: 19 ATAPGFMIGQTPPPAP-----PPPPPP-------PPPSPPCSCSREECPSSPPP------ 60
++ PG PPP P PPPPPP PPP PP P PPP
Sbjct: 667 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLP-GEAGMPPPPPPLPGGPG 725
Query: 61 -PPPPPLPGEPPIPPPPPGL---PPTTHMNGYSH-------LGKKK------RMRSFFWK 103
PPPPP PG P IPPPPPG+ PP G L KK ++R W
Sbjct: 726 IPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWS 785
Query: 104 TIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREA 163
+ E + + WT + F Q T+K+ + G S ++
Sbjct: 786 KLVAEDL-SQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKK 844
Query: 164 R-EEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEV 222
+ +E+ +LD+K + N+ IFL F+ + I I + ++ +K +PE E++
Sbjct: 845 KVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQL 904
Query: 223 KKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAI 282
K L + L+ ++ F + VP R+ A++ K +F ++ +I + A
Sbjct: 905 KMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAAC 964
Query: 283 KELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVA 342
+EL E ++L + L GN MNAG A GF +S L KL DTK+ M LLHF+A
Sbjct: 965 EELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLA 1024
Query: 343 QEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQ-------RDG 395
+ + +L F ++L HV+K +R+S EN + L + + ++ ++Q
Sbjct: 1025 ELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKD 1084
Query: 396 ELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTK 455
+ ++M F++ A E+ +L ++ L ++F D K + ++E F +F
Sbjct: 1085 KFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNM 1144
Query: 456 FNKAVKDNHDREAQE--LRQLQRLKEQEQKQR 485
F +AVK+N R E +R+ + KE+ +K+R
Sbjct: 1145 FLQAVKENQKRRETEEKMRRAKLAKEKAEKER 1176
Score = 67.0 bits (162), Expect = 1e-10
Identities = 30/63 (47%), Positives = 34/63 (53%), Gaps = 5/63 (7%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPP-----GLPPTTH 84
PPP PPPPPPPP P C S P PPPPL G+ IPPPPP G+P +
Sbjct: 609 PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSS 668
Query: 85 MNG 87
+ G
Sbjct: 669 LPG 671
Score = 66.6 bits (161), Expect = 1e-10
Identities = 39/105 (37%), Positives = 42/105 (40%), Gaps = 38/105 (36%)
Query: 14 ENGNIATAPGFMIGQTPPPAPPPPPPPPPP-------------------SPPCSCSREEC 54
++G I P T PP PPPPPPPPPP SPP S +
Sbjct: 591 DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT 650
Query: 55 PSSPPP-------------------PPPPPLPGEPPIPPPPPGLP 80
PPP PPPPPLPG IPPPPP LP
Sbjct: 651 IPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLP 695
Score = 53.5 bits (127), Expect = 1e-06
Identities = 34/76 (44%), Positives = 38/76 (50%), Gaps = 20/76 (26%)
Query: 20 TAPGFMIGQTP-PPAPPPPPP-----PPPPSPPCSCSREECPSSPPPPPPPPLPG----- 68
T P + + P PPAPP P PPPP+P S + P PPPPPPPPLPG
Sbjct: 571 TVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP--PPPPPPPPPPPLPGGVCIS 628
Query: 69 EPP-------IPPPPP 77
PP I PPPP
Sbjct: 629 SPPSLPGGTAISPPPP 644
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 13 KENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPI 72
KE +++ A + P AP PP PP P P PPPPP P PP
Sbjct: 560 KEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP--PPP 617
Query: 73 PPPPPG 78
PPP PG
Sbjct: 618 PPPLPG 623
Score = 45.1 bits (105), Expect = 4e-04
Identities = 25/50 (50%), Positives = 27/50 (54%), Gaps = 13/50 (26%)
Query: 42 PPSPPCSCSREECPSSPPPP-------PPPPLPGE---PPIPPPPPGLPP 81
PPS P SR P +PP P PPPP PG+ PP PPPPP PP
Sbjct: 573 PPSVP---SRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPP 619
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 187 bits (475), Expect = 5e-47
Identities = 147/523 (28%), Positives = 242/523 (46%), Gaps = 73/523 (13%)
Query: 30 PPPAPPPP---------------PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPP 74
P +PPPP PPPPPP P C PPPPPPPLP P PP
Sbjct: 518 PVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACC---------PPPPPPPLP--PGGPP 566
Query: 75 PPPGLPPTTHM------NGYSHLG---KKKR-------MRSFFWKTIPEEQVRGKTNIWT 118
PPG PP M + Y +KKR ++SF W + EE+V G +W
Sbjct: 567 TPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPG--TVWN 624
Query: 119 LAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSS---FREARE--EITILDAK 173
+ +D + E++F S+ R + L S+ + +R+ E++++D +
Sbjct: 625 EIDDMQVFRILDLEDFEKMF--------SAYQRHQKELGSTEDIYLASRKVKELSVIDGR 676
Query: 174 RSMNIGIFLKQFKKSPRSIVEDI-HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDV 232
R+ N I L + K S I + I + E + L + LKF+PE ++ L+ ++
Sbjct: 677 RAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEI 736
Query: 233 SKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELH 292
+++ AD FLY + ++ +Y R++A+ KK+F + + + A +EL+ + L
Sbjct: 737 ERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLR 796
Query: 293 SILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKAN-KPGMNLLHFVAQEAQKKDTI 351
+L ++L GN MN G G A GF+++SL K+ADTK++ ++LLH++ +K
Sbjct: 797 QMLEVILAIGNFMNK-GQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPD 855
Query: 352 LLNFSEKLHHVQKTARLSLENTEAE-------LHLLFVRTKSLKENIQRDGELCQQMEDF 404
+LN +L H+ + A+++L E E L + V ++ + + M DF
Sbjct: 856 ILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDF 915
Query: 405 LQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKD-- 462
+ + ELE E +D+ + F E M+ DE F IF F F++A +D
Sbjct: 916 ITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLE 975
Query: 463 ----NHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSE 501
+ E + R LKEQ +++R ++ A G S E
Sbjct: 976 AMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEE 1018
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 187 bits (474), Expect = 6e-47
Identities = 134/495 (27%), Positives = 235/495 (47%), Gaps = 48/495 (9%)
Query: 22 PGFMIGQTPPPAPPPP------PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPP 75
P + G PP PPPP PPPPPP PP PPPPP PP G P
Sbjct: 541 PSSVPGSLLPPPPPPPLPGGMLPPPPPPLPP---------GGPPPPPGPPPLGAIM---P 588
Query: 76 PPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIE 135
PPG P + S ++SF W +PE ++ G +WT + +D + +E
Sbjct: 589 PPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEG--TVWTEIDDTKVFKILDLEDLE 646
Query: 136 ELFG---QQEDTTKSSLPRRGR------TLNSSFREAREEITILDAKRSMNIGIFLKQFK 186
F +Q+D +S ++ TL+S + +E++++D +R+ N I L + K
Sbjct: 647 RTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKV--KELSVIDGRRAQNCNILLSRLK 704
Query: 187 KSPRSIVEDI-HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL 245
S I I + E + L + LKF+PE ++ L+ ++ +++ AD FL+ +
Sbjct: 705 LSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEM 764
Query: 246 IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM 305
++ +Y R++++ KK+F + + + +R+ +E+ L +L +VL GN M
Sbjct: 765 SRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYM 824
Query: 306 NAGGYAGNAVGFKLSSLLKLADTKAN-KPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQK 364
N G GNA GFK+SSL K+ADTK++ + LLH++ + K +LN +E+L + +
Sbjct: 825 NK-GQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQ 883
Query: 365 TARLSLENTEAELHLLFVRTKSLKENI--------QRDGELCQQMEDFLQFAIEKLRELE 416
A++++ + E+ L K+++ + Q + + F+ A ++E
Sbjct: 884 AAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVE 943
Query: 417 CWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNH------DREAQE 470
E +D + F E+ ++ DE F IF F ++A ++N + E +
Sbjct: 944 DLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERR 1003
Query: 471 LRQLQRLKEQEQKQR 485
R +LKEQ +++R
Sbjct: 1004 ARMEAQLKEQRERER 1018
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 179 bits (454), Expect = 1e-44
Identities = 133/485 (27%), Positives = 218/485 (44%), Gaps = 43/485 (8%)
Query: 30 PPPAPP----PPPPPPPPSPPCSCSREECPSSPPPPPPPPL-----PGEPPIPPPPPGLP 80
PPP P PPPPPPPP PP R P S P PPPPPL PP+P P GL
Sbjct: 315 PPPLPSGGGVPPPPPPPPPPPLPGMR--MPFSGPVPPPPPLGFLGGQNSPPLPILPFGLK 372
Query: 81 PTTHMNGYSHLGKKKRMRSFFWKTI-PEEQVRGKTNIWTLAARQEHHYQIDTKT-IEELF 138
P + MR W I P E N + + + + +D +E F
Sbjct: 373 PKKEFK------PEISMRRLNWLKIRPHEMTE---NCFWIKVNENKYENVDLLCKLENTF 423
Query: 139 GQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQ 198
Q+ K S ++ +E+ LD+K + N+ IFL F+ I I +
Sbjct: 424 CCQQ---KERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
Query: 199 GKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAM 258
++ +K LP+ E++ L F + S L + F+ + V R+ A+
Sbjct: 481 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 540
Query: 259 VLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFK 318
+ K +F +++ DI + TA +E+ + +L LVL GN MNAG GF
Sbjct: 541 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 600
Query: 319 LSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELH 378
LSSL KL DTK+ LLHF+ + ++K +LNF + L + K +++S+E E L
Sbjct: 601 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 660
Query: 379 LLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLID 431
+ + + L++ ++ + +M F+ A E+ L + ++ ++I
Sbjct: 661 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 720
Query: 432 FFCEDKKTMKLDECFQIFRDFCTKFNKAVKDN-----------HDREAQELRQLQRLKEQ 480
++ D K + +++ +F T F +A+K+N R A+EL + +RL+ Q
Sbjct: 721 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 780
Query: 481 EQKQR 485
++K+R
Sbjct: 781 QKKKR 785
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 177 bits (448), Expect = 7e-44
Identities = 131/485 (27%), Positives = 216/485 (44%), Gaps = 42/485 (8%)
Query: 31 PPAPPPP-----PPPPPPSPPCSCSREECPSSPPPPPPPPL-----PGEPPIPPPPPGLP 80
PP PP P PPPPPP PP P S P PPPPPL PP+P P GL
Sbjct: 576 PPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLK 635
Query: 81 PTTHMNGYSHLGKKKRMRSFFW-KTIPEEQVRGKTNIWTLAARQEHHYQIDTK-TIEELF 138
P + MR W K P E N + + + + +D +E F
Sbjct: 636 PKKEFK------PEISMRRLNWLKIRPHEMTE---NCFWIKVNENKYENVDLLCKLENTF 686
Query: 139 GQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQ 198
Q+ K S ++ +E+ LD+K + N+ IFL F+ I I +
Sbjct: 687 CCQQ---KERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 743
Query: 199 GKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAM 258
++ +K LP+ E++ L F + S L + F+ + V R+ A+
Sbjct: 744 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 803
Query: 259 VLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFK 318
+ K +F +++ DI + TA +E+ + +L LVL GN MNAG GF
Sbjct: 804 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 863
Query: 319 LSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELH 378
LSSL KL DTK+ LLHF+ + ++K +LNF + L + K +++S+E E L
Sbjct: 864 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 923
Query: 379 LLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLID 431
+ + + L++ ++ + +M F+ A E+ L + ++ ++I
Sbjct: 924 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 983
Query: 432 FFCEDKKTMKLDECFQIFRDFCTKFNKAVKDN-----------HDREAQELRQLQRLKEQ 480
++ D K + +++ +F T F +A+K+N R A+EL + +RL+ Q
Sbjct: 984 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 1043
Query: 481 EQKQR 485
++K+R
Sbjct: 1044 QKKKR 1048
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 175 bits (444), Expect = 2e-43
Identities = 142/551 (25%), Positives = 241/551 (43%), Gaps = 50/551 (9%)
Query: 30 PPPAPPPP---PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPP--------- 77
PP APP P PPPPPP+PP +P PPPPPPLPG IPPPPP
Sbjct: 551 PPAAPPLPGVGPPPPPPAPPLP------GGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPP 604
Query: 78 ------GLPPTTHMNGYSHLGKKKR--------MRSFFWKTIPEEQVRGKTNIWTLAARQ 123
G+PP ++ G K++ M+ W I ++ N + L ++
Sbjct: 605 PPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTEL--SENCFWLRVKE 662
Query: 124 EHHYQIDTKTIEEL-FGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFL 182
+ D L F Q K++ + + ++ +E + ILD K + N+ IFL
Sbjct: 663 DKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKE-LRILDPKTAQNLSIFL 721
Query: 183 KQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFL 242
++ I I + + ++ +K LPE + + +L + L + F
Sbjct: 722 GSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFG 781
Query: 243 YGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAG 302
+ V R+ +++ K F +++ I + A +EL E + +L LVL G
Sbjct: 782 VVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVG 841
Query: 303 NIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHV 362
N MN+G ++GFK++ L K+ DTK+ LLHF+A ++K +L F E+L HV
Sbjct: 842 NYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHV 901
Query: 363 QKTARLSLENTEAELHLLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLREL 415
+ +++S + ++ L + + L+ +I++ + ++M F + A E+ +L
Sbjct: 902 ESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKL 961
Query: 416 ECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQ 475
+ L ++F D KT+ ++E F +F T F +AV++N+ R E + +
Sbjct: 962 STMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREME-EKTR 1020
Query: 476 RLK------EQEQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSP 529
R K EQE+ +R +L + E V + + F R P +P
Sbjct: 1021 RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP 1080
Query: 530 SYRPPNTRRSR 540
R RSR
Sbjct: 1081 DNRRVPLERSR 1091
Score = 34.3 bits (77), Expect = 0.70
Identities = 15/24 (62%), Positives = 15/24 (62%), Gaps = 2/24 (8%)
Query: 58 PPPPPPPPLPGEPPIPPPPPGLPP 81
P PP PPLPG P PPPP PP
Sbjct: 549 PGPPAAPPLPGVGP--PPPPPAPP 570
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 173 bits (438), Expect = 1e-42
Identities = 140/550 (25%), Positives = 240/550 (43%), Gaps = 50/550 (9%)
Query: 30 PPPAPPPP---PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPP--------- 77
PP APP P PPPPPP+PP +P PPPPPPLPG IPPPPP
Sbjct: 551 PPAAPPLPGVGPPPPPPAPPLP------GGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPP 604
Query: 78 ------GLPPTTHMNGYSHLGKKKR--------MRSFFWKTIPEEQVRGKTNIWTLAARQ 123
G+PP ++ G K++ M+ W I ++ N + L ++
Sbjct: 605 PPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTEL--SENCFWLRVKE 662
Query: 124 EHHYQIDTKTIEEL-FGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFL 182
+ D L F Q K++ + + ++ +E + ILD K + N+ IFL
Sbjct: 663 DKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKE-LRILDPKTAQNLSIFL 721
Query: 183 KQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFL 242
++ I I + + ++ +K LPE + + +L + L + F
Sbjct: 722 GSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFG 781
Query: 243 YGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAG 302
+ V R+ +++ K F +++ I + A +EL E + +L LVL G
Sbjct: 782 VVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVG 841
Query: 303 NIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHV 362
N MN+G ++GFK++ L K+ DTK+ LLHF+A ++K +L F E+L HV
Sbjct: 842 NYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHV 901
Query: 363 QKTARLSLENTEAELHLLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLREL 415
+ +++S + ++ L + + L+ +I++ + ++M F + A E+ +L
Sbjct: 902 ESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKL 961
Query: 416 ECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQ 475
+ L ++F D KT+ ++E F +F T F +AV++N+ R E + +
Sbjct: 962 STMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREME-EKTR 1020
Query: 476 RLK------EQEQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSP 529
R K EQE+ +R +L + E V + + F R P +P
Sbjct: 1021 RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP 1080
Query: 530 SYRPPNTRRS 539
P R+
Sbjct: 1081 VVNHPCATRA 1090
Score = 34.3 bits (77), Expect = 0.70
Identities = 15/24 (62%), Positives = 15/24 (62%), Gaps = 2/24 (8%)
Query: 58 PPPPPPPPLPGEPPIPPPPPGLPP 81
P PP PPLPG P PPPP PP
Sbjct: 549 PGPPAAPPLPGVGP--PPPPPAPP 570
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 168 bits (426), Expect = 2e-41
Identities = 127/468 (27%), Positives = 214/468 (45%), Gaps = 32/468 (6%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYS 89
PPP PPPPPPPPPP PP + P PP PPLP PP+ P P +G +
Sbjct: 555 PPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPL--PGTSSPTVVFNSGLA 612
Query: 90 HLGKKK------RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQE- 142
+ KK RM F W + Q+ G ++ + ++ EE+F +
Sbjct: 613 AVKIKKPIKTKFRMPVFNWVALKPNQING--TVFNEIDDERILEDLNVDEFEEIFKTKAQ 670
Query: 143 ------DTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDI 196
++K +P++G ++T+L+A R+ N+ I L++ K+ I + I
Sbjct: 671 GPAIDLSSSKQKIPQKG----------SNKVTLLEANRAKNLAITLRKAGKTADEICKAI 720
Query: 197 HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSL 253
H + + + ++FLP EVK L+ + + + LS D F+ ++
Sbjct: 721 HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ 780
Query: 254 RIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGN 313
++ M F S L + + A + S ++L IL ++L GN MN+ G
Sbjct: 781 KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNS-SKRGA 839
Query: 314 AVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENT 373
GFKL SL L DTK+ LLH+++ ++K + F +LH+V+K A +SLEN
Sbjct: 840 VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENV 899
Query: 374 EAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFF 433
++ L R L + + +++F+ KL++L+ + QD ++ +F
Sbjct: 900 LLDVKEL-QRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYF 958
Query: 434 CEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQE 481
E+ KT F +F F + +A ++N R+ QE +++L EQE
Sbjct: 959 GENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQE 1006
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 166 bits (419), Expect = 2e-40
Identities = 136/471 (28%), Positives = 219/471 (46%), Gaps = 43/471 (9%)
Query: 32 PAPPPP---PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMN-G 87
PAPPP P PPPP+PP PPPPPPLP + P PP PG P+ + G
Sbjct: 457 PAPPPEEVLPLPPPPAPPL------------PPPPPPLPDKCPPAPPLPGAAPSVVLTVG 504
Query: 88 YSHLGKKK------RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQ 141
S + KK R+ F W + Q+ G +++ ++ +D EELF
Sbjct: 505 LSAIRIKKPIKTKFRLPVFNWTALKPNQISG--TVFSELDDEKILEDLDLDKFEELF--- 559
Query: 142 EDTTKSSLPRRGR--TLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQG 199
TK+ P + N + ++A ++T+L+A R+ N+ I L++ +S I IH
Sbjct: 560 --KTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTF 617
Query: 200 KSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSLRIE 256
+ + + ++FLP EVK L+ + + + +L+ D F+ +V + R+
Sbjct: 618 DLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMA 677
Query: 257 AMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVG 316
M F + L + + A + S ++L +L ++L GN MN+ G G
Sbjct: 678 GMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK-RGAVYG 736
Query: 317 FKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAE 376
FKL SL L DTK+ M LLHF+A ++K L NF +LH V+K A +SLEN
Sbjct: 737 FKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV--- 793
Query: 377 LHLLFVRTKSL-KENIQRDGELCQQ--MEDFLQFAIEKLRELECWKQELQDEAYTLIDFF 433
LL V+ E I+R+ + + +FL KL +L+ + ++ ++ +F
Sbjct: 794 --LLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF 851
Query: 434 CEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQ 484
E KT F +F F + +A ++N R+ QE ++ QE K+
Sbjct: 852 GESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKK 902
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 166 bits (419), Expect = 2e-40
Identities = 136/471 (28%), Positives = 219/471 (46%), Gaps = 43/471 (9%)
Query: 32 PAPPPP---PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMN-G 87
PAPPP P PPPP+PP PPPPPPLP + P PP PG P+ + G
Sbjct: 508 PAPPPEEVLPLPPPPAPPL------------PPPPPPLPDKCPPAPPLPGAAPSVVLTVG 555
Query: 88 YSHLGKKK------RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQ 141
S + KK R+ F W + Q+ G +++ ++ +D EELF
Sbjct: 556 LSAIRIKKPIKTKFRLPVFNWTALKPNQISG--TVFSELDDEKILEDLDLDKFEELF--- 610
Query: 142 EDTTKSSLPRRGR--TLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQG 199
TK+ P + N + ++A ++T+L+A R+ N+ I L++ +S I IH
Sbjct: 611 --KTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTF 668
Query: 200 KSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSLRIE 256
+ + + ++FLP EVK L+ + + + +L+ D F+ +V + R+
Sbjct: 669 DLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMA 728
Query: 257 AMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVG 316
M F + L + + A + S ++L +L ++L GN MN+ G G
Sbjct: 729 GMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK-RGAVYG 787
Query: 317 FKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAE 376
FKL SL L DTK+ M LLHF+A ++K L NF +LH V+K A +SLEN
Sbjct: 788 FKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV--- 844
Query: 377 LHLLFVRTKSL-KENIQRDGELCQQ--MEDFLQFAIEKLRELECWKQELQDEAYTLIDFF 433
LL V+ E I+R+ + + +FL KL +L+ + ++ ++ +F
Sbjct: 845 --LLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF 902
Query: 434 CEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQ 484
E KT F +F F + +A ++N R+ QE ++ QE K+
Sbjct: 903 GESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKK 953
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 154 bits (388), Expect = 6e-37
Identities = 129/501 (25%), Positives = 210/501 (41%), Gaps = 62/501 (12%)
Query: 15 NGNIATAPGFMIGQTPP-------PAPPPPPPPPPPSPPCSCSREECPSSPP-------- 59
+G A PG G P PAP PPPPPP P +E PS+PP
Sbjct: 512 SGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGS 571
Query: 60 --PPPPPPLPGE---------------------PPIPPPPPGLPPTTHMNGYSHLG---- 92
PPP PPLPG+ PP PPPPPG PP S LG
Sbjct: 572 PEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVK 631
Query: 93 ------KKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTK 146
K RM W + Q+ G ++T ++ ++D EE F TK
Sbjct: 632 AKKPIQTKFRMPLLNWVALKPSQITG--TVFTELNDEKVLQELDMSDFEEQF-----KTK 684
Query: 147 SSLPRRGRTL--NSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHY 204
S P + + + ++A + T+++A R+ N+ I L++ I + I +
Sbjct: 685 SQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQAL 744
Query: 205 GSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSLRIEAMVLK 261
G + L ++FLP E + F + + +LS D F+ ++P R+ +
Sbjct: 745 GLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFL 804
Query: 262 KEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSS 321
F + L + + A + S ++L IL +VL GN MN+ G A GF+L S
Sbjct: 805 GNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNS-SKRGAAYGFRLQS 863
Query: 322 LLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLF 381
L L + K+ LLH++ + +K L F LH + K +SL++ A++ L
Sbjct: 864 LDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQ 923
Query: 382 VRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMK 441
+ + R + C +++FL+ + +L + Q+ +++++F E+ KT
Sbjct: 924 RGLELTQREFVRQDD-CMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTS 982
Query: 442 LDECFQIFRDFCTKFNKAVKD 462
F +F F + KA ++
Sbjct: 983 PGLFFSLFSRFIKAYKKAEQE 1003
Score = 30.8 bits (68), Expect = 7.7
Identities = 44/191 (23%), Positives = 67/191 (35%), Gaps = 20/191 (10%)
Query: 884 QGAVAKSVRTLTASENESMRKVMPITKSSRGA-------GWRRPELSSRGPSQNPP---S 933
Q VA L +ENESM K+ + K A R E ++ G S+ PP
Sbjct: 405 QEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEK 464
Query: 934 STDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKPSA--KPLRN 991
+ +R +++ EE+ L R G +P+ + PS P
Sbjct: 465 APPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPV----AVATPSGGDAPTPG 520
Query: 992 LPRQKPEENKTCRAHSEGPESPKEEPKTPSVPS----VPHELPRVPSFARNTVASSSRSM 1047
+P P + A +P P P +PS P P+ P + + +
Sbjct: 521 VPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPL 580
Query: 1048 RTDLPPVAKAP 1058
DLPP P
Sbjct: 581 PGDLPPPPPPP 591
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 153 bits (386), Expect = 1e-36
Identities = 131/478 (27%), Positives = 201/478 (42%), Gaps = 40/478 (8%)
Query: 10 VSDKENGNIATAPGFMIGQTPPPAPPPPPPPPP-----PS---------PPCSCSREECP 55
+S E G+ T PPP PPPPPP P PS P + ++
Sbjct: 731 ISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQ 790
Query: 56 SSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTN 115
S P PPPPP PP+PPP P PP G H ++ K + EQV
Sbjct: 791 LSHPVPPPPP----PPLPPPVPCAPPMLS-RGLGH--RRSETSHMSVKRLRWEQVENSEG 843
Query: 116 -IWTLAARQEHHYQIDTKT----IEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITIL 170
IW + ++ +E FG Q+ P FR+ +E + IL
Sbjct: 844 TIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPE-------PFRK-KEVVEIL 895
Query: 171 DAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSG 230
K++ N I L K SP + + + + L + L F P+++E ++ +AF
Sbjct: 896 SHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFRE 955
Query: 231 DVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEE 290
+LS D F+ ++ VP Y R+ ++ + + + LR A EL + +
Sbjct: 956 APGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRK 1015
Query: 291 LHSILHLVLQAGNIMNAGGYAGN-AVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKD 349
L IL VL GN +N G N GFK++ L +L TK LH +A+ +
Sbjct: 1016 LAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHF 1075
Query: 350 TILLNFSEKLHHVQKTARL---SLENTEAELHLLFVRTKSLKENIQRDGE--LCQQMEDF 404
LL F++ L V A++ +L + A+LH + ++I E M F
Sbjct: 1076 PELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSF 1135
Query: 405 LQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKD 462
L+ A LR L+ ++E +E + FF ED K + F IF +F +KF +A+ D
Sbjct: 1136 LETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 152 bits (384), Expect = 2e-36
Identities = 136/517 (26%), Positives = 223/517 (43%), Gaps = 69/517 (13%)
Query: 16 GNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPP------PPLPGE 69
G+++ AP P A PP PPPPPP PP P PPPPPP PP PG
Sbjct: 663 GSLSPAPPM----PPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGG 718
Query: 70 PPIPPPPPGLPPTTHMNGYSHLGKKKR-------------MRSFFWKTIPEEQVRGKTNI 116
PP PPPPGL P + LG M+ +W I + R +
Sbjct: 719 PPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRI-QISDRSQNAT 777
Query: 117 WTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSM 176
TL E D E LF +DTT+ T + ++ I +LD KRS
Sbjct: 778 PTLWDSLEEPDIRDPSEFEYLF--SKDTTQQKKKPLSETYEKK-NKVKKIIKLLDGKRSQ 834
Query: 177 NIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAF-----SGD 231
+GI + + I + I ETL + + +E+ K++ + +
Sbjct: 835 TVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEE 894
Query: 232 VSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEEL 291
+ L + FL+ L Q+PN++ R + ++ + F +SL+ + ++ A K+L+ + +
Sbjct: 895 LKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSV 954
Query: 292 HSILHLVLQAGNIMNAGGYA-GNAVGFKLSSLLKLADTKANKPGMNLLHFVA-------- 342
IL L+L GN MN G G A G+ L L KL D K+ G+NL+ +V
Sbjct: 955 KDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYD 1014
Query: 343 QEAQKKDTIL-------------LNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKE 389
QEA + ++ + F + + ++K R LE +E + ++ V +S KE
Sbjct: 1015 QEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRKLKR-QLEASEKQ--MVVVCKESPKE 1071
Query: 390 NIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFF----CEDKKTMKLDEC 445
+Q ++E+F Q A ++ + E + Q T + +F +K +
Sbjct: 1072 YLQ---PFKDKLEEFFQKAKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYV 1128
Query: 446 FQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQ 482
F ++ +FC+ F K RE++ + + +RLK ++
Sbjct: 1129 FMVWYEFCSDFKTIWK----RESKNISK-ERLKMAQE 1160
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 114 bits (284), Expect = 7e-25
Identities = 137/527 (25%), Positives = 214/527 (40%), Gaps = 95/527 (18%)
Query: 26 IGQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP----PPPPPLP-- 67
+G PPP PPPPP PPPPP P P PPP PPPP LP
Sbjct: 1182 VGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVS 1241
Query: 68 --------GEPPIPPP------PPGLPPTTHMNGYSH-LGKKKR-------MRSFFWKTI 105
G +P P PP LP G + G +K+ M+ +W I
Sbjct: 1242 GPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRI 1301
Query: 106 PEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFRE--A 163
R + +L + ID EELF +K+++ R + ++ + + A
Sbjct: 1302 QLHSKRDSST--SLIWEKIEEPSIDCHEFEELF------SKTAVKERKKPISDTISKTKA 1353
Query: 164 REEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVK 223
++ + +L KRS +GI + + I + + ETL+ + +S+E++
Sbjct: 1354 KQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELE 1413
Query: 224 KLKAFSG------DVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITV 277
K++ + L + FLY L +PN+S R+ ++ + F S S+ + +
Sbjct: 1414 KIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLEL 1473
Query: 278 LRTAIKELMSCEELHSILHLVLQAGNIMNAGGYA-GNAVGFKLSSLLKLADTKANKPGMN 336
L+ + L + + +L LVL GN MN G G A GF L L KL D K++ +
Sbjct: 1474 LQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRS 1533
Query: 337 LLHFVA-------QEAQKKDTILLNFSE----------KLHHVQKTARLSLENTEA-ELH 378
LL ++ E K+ L E K QK R ++ +A E+
Sbjct: 1534 LLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVE 1593
Query: 379 LLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRE----LECWKQELQDEAYTLIDFFC 434
V S KE++Q E +Q +Q I++ E E K L+ AY FF
Sbjct: 1594 AGKVYQVSSKEHMQPFKENMEQF--IIQAKIDQEAEENSLTETHKCFLETTAY----FFM 1647
Query: 435 EDK---KTMKLDECFQI-------FRDFCTKFNKAVKDNHDREAQEL 471
+ K K + + F I F+DF K NK + +EA+E+
Sbjct: 1648 KPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKEAEEV 1694
Score = 54.3 bits (129), Expect = 6e-07
Identities = 36/93 (38%), Positives = 38/93 (40%), Gaps = 41/93 (44%)
Query: 29 TPPPAP--------------PPPPPPPP------------PSPPCSCSREECPSSPPP-- 60
+PPP P PPPPPP P P PP E P PPP
Sbjct: 857 SPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLP 916
Query: 61 ----PPPPPLPGE-----PPIP----PPPPGLP 80
PPPPPLPG PP+P PPPP LP
Sbjct: 917 GAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP 949
Score = 53.9 bits (128), Expect = 8e-07
Identities = 41/108 (37%), Positives = 46/108 (42%), Gaps = 39/108 (36%)
Query: 18 IATAPGFMIGQTPP-------PAPPPP------PPPPP-------PSPPCSCSREECP-- 55
+ T P I Q PP P PPPP PPPPP P PP + P
Sbjct: 888 VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPP 947
Query: 56 ----SSPPPPP--------PPPLPGEPPIPPPPP----GLPPTTHMNG 87
+ PPPPP PPPLPG IPPPPP G+PP + G
Sbjct: 948 LPGAAIPPPPPLPGAGIPLPPPLPGAG-IPPPPPLPGAGIPPPPPLPG 994
Score = 52.8 bits (125), Expect = 2e-06
Identities = 36/84 (42%), Positives = 37/84 (44%), Gaps = 31/84 (36%)
Query: 22 PGFMIGQTPP------PAPPPPP----PPPPPSPPCSCSREECPSSPPP------PPPPP 65
PG I PP P PPP P PPPPP P PPP PPPPP
Sbjct: 949 PGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPP 1002
Query: 66 LPGE-----PPIP----PPPPGLP 80
LPG PP+P PPPP LP
Sbjct: 1003 LPGAGIPPPPPLPGAGIPPPPPLP 1026
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 974 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1027
Query: 69 E-----PPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1028 AGIPPPPPLPGAGIPPPPPLP 1048
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/82 (41%), Positives = 36/82 (43%), Gaps = 27/82 (32%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 985 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1038
Query: 69 E---PPIPPPPPGLPPTTHMNG 87
PP P P G+PP + G
Sbjct: 1039 AGIPPPPPLPGAGIPPPPPLPG 1060
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/82 (41%), Positives = 36/82 (43%), Gaps = 27/82 (32%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 996 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1049
Query: 69 E---PPIPPPPPGLPPTTHMNG 87
PP P P G+PP + G
Sbjct: 1050 AGIPPPPPLPGAGIPPPPPLPG 1071
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1007 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1060
Query: 69 E-----PPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1061 AGIPPPPPLPGAGIPPPPPLP 1081
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1018 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1071
Query: 69 E-----PPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1072 AGIPPPPPLPGAGIPPPPPLP 1092
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1082
Query: 69 E-----PPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1083 AGIPPPPPLPGAGIPPPPPLP 1103
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/82 (41%), Positives = 36/82 (43%), Gaps = 27/82 (32%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1051 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1104
Query: 69 ---EPPIPPPPPGLPPTTHMNG 87
PP P P G+PP + G
Sbjct: 1105 VGIPPPPPLPGAGIPPPPPLPG 1126
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1062 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGVGIPPPPPLPG 1115
Query: 69 E-----PPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1116 AGIPPPPPLPGAGIPPPPPLP 1136
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1139 GIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGVGIPPPPPLPG 1192
Query: 69 -----EPPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1193 VGIPPPPPLPGAGIPPPPPLP 1213
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/78 (42%), Positives = 35/78 (44%), Gaps = 26/78 (33%)
Query: 30 PPPAP-----PPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPGE--- 69
PPP P PPPP PPPPP P PPP PPPPPLPG
Sbjct: 967 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPGAGIP 1020
Query: 70 PPIPPPPPGLPPTTHMNG 87
PP P P G+PP + G
Sbjct: 1021 PPPPLPGAGIPPPPPLPG 1038
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/81 (43%), Positives = 36/81 (44%), Gaps = 33/81 (40%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1073 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP------PPPPLPGAGIPPPPPLPG 1126
Query: 69 E-----PPIP----PPPPGLP 80
PP+P PPPP LP
Sbjct: 1127 AGIPPPPPLPGAGIPPPPPLP 1147
Score = 52.4 bits (124), Expect = 2e-06
Identities = 34/82 (41%), Positives = 36/82 (43%), Gaps = 27/82 (32%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLPG 68
G PPP PPPPP PPPPP P PPP PPPPPLPG
Sbjct: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPG 1181
Query: 69 ---EPPIPPPPPGLPPTTHMNG 87
PP P P G+PP + G
Sbjct: 1182 VGIPPPPPLPGVGIPPPPPLPG 1203
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/72 (45%), Positives = 36/72 (50%), Gaps = 16/72 (22%)
Query: 31 PPAP----PPPPPPP----PPSPPCSCSREECPSSPPP---PPPPPLPGEPPIPPPPP-- 77
PP P PPPPP P PP PP + P P PPPPPLPG IPPPPP
Sbjct: 935 PPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPG-AGIPPPPPLP 993
Query: 78 --GLPPTTHMNG 87
G+PP + G
Sbjct: 994 GAGIPPPPPLPG 1005
Score = 51.6 bits (122), Expect = 4e-06
Identities = 35/82 (42%), Positives = 37/82 (45%), Gaps = 27/82 (32%)
Query: 27 GQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPP------PPPPPLP- 67
G PPP PPPPP PPPPP P PPP PPPPPLP
Sbjct: 1095 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPR 1148
Query: 68 -GEPPIPP-PPPGLPPTTHMNG 87
G PP PP P G+PP + G
Sbjct: 1149 VGIPPPPPLPGAGIPPPPPLPG 1170
Score = 50.4 bits (119), Expect = 9e-06
Identities = 30/72 (41%), Positives = 32/72 (44%), Gaps = 14/72 (19%)
Query: 30 PPPAPPPPPPPPPPSP----PCSCSREECPSSPPPP-------PPPPLPGE---PPIPPP 75
PPP P PPPPP P P PPPP PPPPLPG PP P P
Sbjct: 945 PPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1004
Query: 76 PPGLPPTTHMNG 87
G+PP + G
Sbjct: 1005 GAGIPPPPPLPG 1016
Score = 50.4 bits (119), Expect = 9e-06
Identities = 31/74 (41%), Positives = 34/74 (45%), Gaps = 28/74 (37%)
Query: 26 IGQTPPPA------PPPPP------PPPPPSPPCSCSREECPSSPPPPPPPP---LPGEP 70
+G PPP PPPPP PPPPP P PPPPP P +P P
Sbjct: 1105 VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI---------PPPPPLPRVGIPPPP 1155
Query: 71 PIP----PPPPGLP 80
P+P PPPP LP
Sbjct: 1156 PLPGAGIPPPPPLP 1169
Score = 49.7 bits (117), Expect = 2e-05
Identities = 34/80 (42%), Positives = 36/80 (45%), Gaps = 15/80 (18%)
Query: 22 PGFMIGQTPPPAPPPPPPPPP------PSPPCSCSREECPSSPPP----PPPPPLPGEPP 71
PG I PP PPPPP P PP P P P PPPPPLPG
Sbjct: 1015 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AG 1073
Query: 72 IPPPPP----GLPPTTHMNG 87
IPPPPP G+PP + G
Sbjct: 1074 IPPPPPLPGAGIPPPPPLPG 1093
Score = 49.7 bits (117), Expect = 2e-05
Identities = 34/80 (42%), Positives = 36/80 (45%), Gaps = 15/80 (18%)
Query: 22 PGFMIGQTPPPAPPPPPPPPP------PSPPCSCSREECPSSPPP----PPPPPLPGEPP 71
PG I PP PPPPP P PP P P P PPPPPLPG
Sbjct: 1081 PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AG 1139
Query: 72 IPPPPP----GLPPTTHMNG 87
IPPPPP G+PP + G
Sbjct: 1140 IPPPPPLPRVGIPPPPPLPG 1159
Score = 37.0 bits (84), Expect = 0.11
Identities = 29/85 (34%), Positives = 31/85 (36%), Gaps = 23/85 (27%)
Query: 22 PGFMIGQTPPP---------APPPPPPPPPPSPPCSCSREECPSSP-------PPPPPPP 65
P I Q PPP P PP S S E SS P PPP P
Sbjct: 803 PTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
Query: 66 -------LPGEPPIPPPPPGLPPTT 83
+PG +PPPPP LP T
Sbjct: 863 CTESSSSMPGLGMVPPPPPPLPGMT 887
Score = 34.3 bits (77), Expect = 0.70
Identities = 30/118 (25%), Positives = 43/118 (36%), Gaps = 11/118 (9%)
Query: 997 PEENKTCRAHSEGPESPKEEPKTPSVPSVPHELP--RVPSFARNTVASSSRSMRTDLPPV 1054
P+ + A S+ PES EP+ P P P LP PS A+ T P
Sbjct: 267 PDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFP 326
Query: 1055 AKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLRRASSARAPKKRPESAEGPSANTEAP 1112
PG + +R GD ++ +D + AP+ P P +AP
Sbjct: 327 EAGPG--EEAAGAPVRGAGDTDEEGEED-------AFEDAPRGSPGEEWAPEVGEDAP 375
Score = 32.0 bits (71), Expect = 3.5
Identities = 39/149 (26%), Positives = 62/149 (41%), Gaps = 17/149 (11%)
Query: 467 EAQELRQLQ-RLKEQEQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPIS 525
+ Q+ +QLQ +L++Q+Q+Q+ E A + S L GL FL +
Sbjct: 206 QQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFL------GLDRFL----LG 255
Query: 526 PSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQARPTIAC 585
PS + P + + +L +D ES P EP + S P P P++
Sbjct: 256 PSGGAGEAPGSPDTEQALSALSDLP-----ESLAAEPREPQQPPS-PGGLPVSEAPSLPA 309
Query: 586 LEPAEVRHQDSSFAHKPQASGGQEEAPNP 614
+PA S+ P+A G+E A P
Sbjct: 310 AQPAAKDSPSSTAFPFPEAGPGEEAAGAP 338
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 107 bits (268), Expect = 5e-23
Identities = 117/506 (23%), Positives = 212/506 (41%), Gaps = 67/506 (13%)
Query: 26 IGQTPPPAPPPPPPP-----PPPSPPCSCSREECPSSPPPP-----PPPPLPGEPPIPPP 75
+G P PPPPPPP PPP PPPP PPPP+PG +PPP
Sbjct: 838 LGHREAPGPPPPPPPTFLGLPPP--------------PPPPLLDSIPPPPVPGNLLVPPP 883
Query: 76 -----PPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTN------IWTLAARQE 124
P GL + G KKK+ FW + K N +W+ +
Sbjct: 884 PVFNAPQGLGWSQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWS----KL 939
Query: 125 HHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQ 184
++DT +E LF + + + S+ ++ ++ R+EI +LD+KRS I I L
Sbjct: 940 EPIKVDTSRLEHLF--ESKSKELSVSKK-----TAADGKRQEIIVLDSKRSNAINIGLTV 992
Query: 185 FKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLK--AFSGDVSKLSLADSFL 242
PR+I I E + + L +P EE +K++ + L A+ FL
Sbjct: 993 L-PPPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFL 1051
Query: 243 YGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAG 302
L + S R+ K ++ + + + L+ I +L + + L IL +L G
Sbjct: 1052 LTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIG 1111
Query: 303 NIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHV 362
N +N NA F+LS L K+ + K +LLH V + + ++ +
Sbjct: 1112 NFLN----GTNAKAFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAI 1167
Query: 363 QKTARLSLENTEAELHLLFVRTKSLKENIQRDGE------LCQQMEDFLQFAIEKLRELE 416
++A++ + + L + R K+ ++++ + L Q+M +FL+ E++ L+
Sbjct: 1168 TRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILK 1227
Query: 417 CWKQELQDEAYTLIDFFCEDK---KTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQ 473
+ + + ++ + F + + +++ +I +F ++ + +R Q+ +Q
Sbjct: 1228 IVHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEY----RTTRERVLQQ-KQ 1282
Query: 474 LQRLKEQEQKQRSWATGELGAFGRSS 499
+ + K R + G F SS
Sbjct: 1283 KRANHRERNKTRGKMITDSGKFSGSS 1308
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 82.8 bits (203), Expect = 2e-15
Identities = 119/572 (20%), Positives = 220/572 (38%), Gaps = 83/572 (14%)
Query: 30 PPPAPPPP----PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIP---PPPPGLPPT 82
P P+PP P PPPPP PP PPP P P PP+P P P +P +
Sbjct: 570 PAPSPPLPLLSGVPPPPPLPP------------PPPIKGPFPPPPPLPLAAPLPHSVPDS 617
Query: 83 THMNGYSHLGKKKRMRSFFWKTIPEEQVRGKT--------NIWTLAARQEHHYQIDTKTI 134
S L K++ FW+ + G + +W +DT +
Sbjct: 618 ------SALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWA----SLDPVSVDTARL 667
Query: 135 EELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVE 194
E LF E K LP + + R T+LD KRS I I L P +++
Sbjct: 668 EHLF---ESRAKEVLPSK-----KAGEGRRTMTTVLDPKRSNAINIGLTTL--PPVHVIK 717
Query: 195 DIHQGKSEH-YGSETLREFLKFLPESEEVKKLK--AFSGDVSKLSLADSFLYGLIQVPNY 251
E + + + L +P EE +K++ + L A++FL L +
Sbjct: 718 AALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGL 777
Query: 252 SLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYA 311
+ R++ K ++ + + L+ +++L+ IL +L GN +N
Sbjct: 778 AARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLN----G 833
Query: 312 GNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLE 371
+ GF+LS L K+++ K +LLH + + + ++ + + A++ E
Sbjct: 834 SQSSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFE 893
Query: 372 NTEAELHLLFVRTKSLKENIQRDGE------LCQQMEDFLQFAIEKLRELECWKQELQDE 425
L L R+++ +E+++ + L ++ FL ++ L + + +
Sbjct: 894 QLTENLGQLERRSRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNR 953
Query: 426 AYTL---IDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQ 482
+ + + + + +++ + R+F ++ R +E Q+ K+
Sbjct: 954 FHAFLLYLGYTPQAAREVRIMQFCHTLREFALEY---------RTCRERVLQQQQKQATY 1004
Query: 483 KQRSWATGEL--------GAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPP 534
++R+ G + G G + S V + G H S + RP
Sbjct: 1005 RERNKTRGRMITETEKFSGVAGEAPSNPSVPVAVSSGPGRGDADSHAS--MKSLLTSRPE 1062
Query: 535 NTRRSRLSLG-PSADRELLTFLESSTGSPEEP 565
+T +R S G + ++ + ST SPEEP
Sbjct: 1063 DTTHNRRSRGMVQSSSPIMPTVGPSTASPEEP 1094
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 76.3 bits (186), Expect = 2e-13
Identities = 33/69 (47%), Positives = 38/69 (55%), Gaps = 11/69 (15%)
Query: 28 QTPPPAPPPPPPPPPPSPPCSCSREECPS-----------SPPPPPPPPLPGEPPIPPPP 76
+TPPP PPPPP PP P P S + P+ +PPPPPPPP P PP PPPP
Sbjct: 1956 ETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPP 2015
Query: 77 PGLPPTTHM 85
P PP +
Sbjct: 2016 PSAPPQVQL 2024
Score = 61.2 bits (147), Expect = 5e-09
Identities = 25/46 (54%), Positives = 27/46 (58%), Gaps = 11/46 (23%)
Query: 28 QTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIP 73
Q PPP PPPPPPPPPP PP PPPPPPP P + +P
Sbjct: 1991 QAPPPTPPPPPPPPPPPPP-----------PPPPPPPSAPPQVQLP 2025
Score = 50.4 bits (119), Expect = 9e-06
Identities = 24/52 (46%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPP 81
PPP PPPPPPPPPP PP + + + P S P P + + P P LPP
Sbjct: 2000 PPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMMQ---PVQHPALPP 2048
Score = 41.2 bits (95), Expect = 0.006
Identities = 16/28 (57%), Positives = 21/28 (75%)
Query: 17 NIATAPGFMIGQTPPPAPPPPPPPPPPS 44
++++AP + QTPPP PPPPPPPP S
Sbjct: 3104 SLSSAPTKPLLQTPPPPPPPPPPPPSSS 3131
Score = 39.3 bits (90), Expect = 0.022
Identities = 19/36 (52%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 55 PSSPP-PPPPPPLPGEPPIPPPPPGLPPTTHMNGYS 89
PSSP PPPPPP P PP PP P + P N S
Sbjct: 1952 PSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVS 1987
Score = 35.8 bits (81), Expect = 0.24
Identities = 33/109 (30%), Positives = 45/109 (41%), Gaps = 24/109 (22%)
Query: 8 SLVSDKENGNIATAPGF-MIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPL 66
SL +N N T PG M+G P SP S S P PL
Sbjct: 3072 SLPGFPQNSNTLTPPGAGMLGF---------PTSATSSPALSLSSA---------PTKPL 3113
Query: 67 PGEPPIPPPPPGLPPTTHMNG-----YSHLGKKKRMRSFFWKTIPEEQV 110
PP PPPPP PP++ ++G + +KK+ + K I EE++
Sbjct: 3114 LQTPPPPPPPPPPPPSSSLSGQQTEQQNKESEKKQTKPNKVKKIKEEEL 3162
Score = 32.7 bits (73), Expect = 2.0
Identities = 42/153 (27%), Positives = 59/153 (38%), Gaps = 32/153 (20%)
Query: 928 SQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKPSAK 987
+++ +TD V + +V + A+ P SSGS ++ P
Sbjct: 2304 TEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTP------------------ 2345
Query: 988 PLRNLPRQKPEENKTCRAHSEGPESPKEEPK--TPSVPS--VPHELPRVPSFARNTVASS 1043
+P KPE KT S PE P E+PK PS PS LP + + AS+
Sbjct: 2346 ---LIPSPKPEPEKT----SPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQAST 2398
Query: 1044 SRSMRTDLPPVAKAPG-ITRTVSQRQLRVKGDP 1075
++ PP K P I R S Q V P
Sbjct: 2399 AQPQPQPQPP--KQPQLIGRPPSASQTPVPSSP 2429
Score = 31.2 bits (69), Expect = 5.9
Identities = 20/59 (33%), Positives = 23/59 (38%), Gaps = 7/59 (11%)
Query: 31 PPAPPPPPPPPPPSPPCSCSREECP----SSPPPPPPPPLPGEPPIPPPPP---GLPPT 82
P P P PSPP ++ P SS PP P P PP P G PP+
Sbjct: 2361 PEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPS 2419
Score = 30.8 bits (68), Expect = 7.7
Identities = 26/88 (29%), Positives = 31/88 (35%), Gaps = 13/88 (14%)
Query: 7 VSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPP----PPPSPPCSCSREECPSSPPPPP 62
VS +D A A G + P P P P P P P P ++ PS P
Sbjct: 2321 VSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGT 2380
Query: 63 PPPLP-----GEPP----IPPPPPGLPP 81
P LP +PP P P PP
Sbjct: 2381 KPALPLASTSSDPPQASTAQPQPQPQPP 2408
>gi|169163027 PREDICTED: similar to Putative acrosin-like protease
[Homo sapiens]
Length = 355
Score = 69.3 bits (168), Expect = 2e-11
Identities = 43/109 (39%), Positives = 54/109 (49%), Gaps = 22/109 (20%)
Query: 30 PPPAP-PPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGY 88
PPP P PP PP P PP PS PPPPPPPP P PP PPPPP TT +
Sbjct: 264 PPPRPLPPRPPAAQPRPP--------PSPPPPPPPPPSPLPPPPPPPPPTPSSTTKLP-- 313
Query: 89 SHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEEL 137
L KR++ E ++GKT + ++HY ++T + EL
Sbjct: 314 QGLSFAKRLQQLI------EVLKGKT-----YSDGKNHYDMETTELPEL 351
Score = 51.2 bits (121), Expect = 5e-06
Identities = 26/57 (45%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSR----EECPSSPPPPPPPPLPGEPPIPPPPPGLPPT 82
PPP PPP PP S P S + P PP PP P PP PPPPP PP+
Sbjct: 237 PPPTTRPPPIRPPFSHPLSAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPPS 293
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 68.6 bits (166), Expect = 3e-11
Identities = 36/73 (49%), Positives = 40/73 (54%), Gaps = 20/73 (27%)
Query: 23 GFMIGQTPPPAPPPPPP------------PPPPSPPCSCSREECPSS--PPPPPPPPLPG 68
G ++G P APPPPPP PPPP PP PS+ PPPPPPPPLP
Sbjct: 305 GIVLG---PLAPPPPPPLPPGPAQASVALPPPPGPP---PPPPLPSTGPPPPPPPPPLPN 358
Query: 69 EPPIPPPPPGLPP 81
+ P PPPPP PP
Sbjct: 359 QVPPPPPPPPAPP 371
Score = 56.6 bits (135), Expect = 1e-07
Identities = 25/45 (55%), Positives = 26/45 (57%), Gaps = 10/45 (22%)
Query: 30 PPPAPPPPPP-------PPPPSPPCSCSREECPSSPPPPPPPPLP 67
PPP PPPPPP PPPP PP + P PPPPP PPLP
Sbjct: 332 PPPGPPPPPPLPSTGPPPPPPPPPLP---NQVPPPPPPPPAPPLP 373
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/51 (45%), Positives = 24/51 (47%), Gaps = 15/51 (29%)
Query: 32 PAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPT 82
P PPPPPP PP P +S PPPP PPPPP LP T
Sbjct: 310 PLAPPPPPPLPPGP--------AQASVALPPPPG-------PPPPPPLPST 345
Score = 40.8 bits (94), Expect = 0.007
Identities = 17/30 (56%), Positives = 18/30 (60%), Gaps = 6/30 (20%)
Query: 27 GQTPPPAPPP------PPPPPPPSPPCSCS 50
G PPP PPP PPPPPPP+PP S
Sbjct: 346 GPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
Score = 37.4 bits (85), Expect = 0.082
Identities = 28/86 (32%), Positives = 29/86 (33%), Gaps = 38/86 (44%)
Query: 19 ATAPGFMIGQTPPPAPPP------PPPPPPPSPPCSCSREECPSSPPP------------ 60
A+ PG P P P PPPP PP
Sbjct: 286 ASEPGLQAASQPAETPSQQGIVLGPLAPPPP--------------PPLPPGPAQASVALP 331
Query: 61 -----PPPPPLPGE-PPIPPPPPGLP 80
PPPPPLP PP PPPPP LP
Sbjct: 332 PPPGPPPPPPLPSTGPPPPPPPPPLP 357
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 68.6 bits (166), Expect = 3e-11
Identities = 36/73 (49%), Positives = 40/73 (54%), Gaps = 20/73 (27%)
Query: 23 GFMIGQTPPPAPPPPPP------------PPPPSPPCSCSREECPSS--PPPPPPPPLPG 68
G ++G P APPPPPP PPPP PP PS+ PPPPPPPPLP
Sbjct: 305 GIVLG---PLAPPPPPPLPPGPAQASVALPPPPGPP---PPPPLPSTGPPPPPPPPPLPN 358
Query: 69 EPPIPPPPPGLPP 81
+ P PPPPP PP
Sbjct: 359 QVPPPPPPPPAPP 371
Score = 56.6 bits (135), Expect = 1e-07
Identities = 25/45 (55%), Positives = 26/45 (57%), Gaps = 10/45 (22%)
Query: 30 PPPAPPPPPP-------PPPPSPPCSCSREECPSSPPPPPPPPLP 67
PPP PPPPPP PPPP PP + P PPPPP PPLP
Sbjct: 332 PPPGPPPPPPLPSTGPPPPPPPPPLP---NQVPPPPPPPPAPPLP 373
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/51 (45%), Positives = 24/51 (47%), Gaps = 15/51 (29%)
Query: 32 PAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPT 82
P PPPPPP PP P +S PPPP PPPPP LP T
Sbjct: 310 PLAPPPPPPLPPGP--------AQASVALPPPPG-------PPPPPPLPST 345
Score = 40.8 bits (94), Expect = 0.007
Identities = 17/30 (56%), Positives = 18/30 (60%), Gaps = 6/30 (20%)
Query: 27 GQTPPPAPPP------PPPPPPPSPPCSCS 50
G PPP PPP PPPPPPP+PP S
Sbjct: 346 GPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
Score = 37.4 bits (85), Expect = 0.082
Identities = 28/86 (32%), Positives = 29/86 (33%), Gaps = 38/86 (44%)
Query: 19 ATAPGFMIGQTPPPAPPP------PPPPPPPSPPCSCSREECPSSPPP------------ 60
A+ PG P P P PPPP PP
Sbjct: 286 ASEPGLQAASQPAETPSQQGIVLGPLAPPPP--------------PPLPPGPAQASVALP 331
Query: 61 -----PPPPPLPGE-PPIPPPPPGLP 80
PPPPPLP PP PPPPP LP
Sbjct: 332 PPPGPPPPPPLPSTGPPPPPPPPPLP 357
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 68.6 bits (166), Expect = 3e-11
Identities = 176/751 (23%), Positives = 258/751 (34%), Gaps = 145/751 (19%)
Query: 454 TKFNKAVKDNHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDVELLTKKGAE 513
T F+ VK+ D L QL+ + K++S + G SSSE + + K G
Sbjct: 1345 TGFSSEVKE--DLNGPFLNQLETDPSLDMKEQSTRSS-----GHSSSELSPDAVEKAGMS 1397
Query: 514 GLLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPNKFHSLPR 573
P+ + P R P+ RS SS SPE + LPR
Sbjct: 1398 SNQSI--SSPVLDAVP--RTPSRERS-----------------SSASSPEMKD---GLPR 1433
Query: 574 SSPRQAR----PTIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLAAAQPEN 629
+ R++R P + RH S +S G ++ P PS + ++
Sbjct: 1434 TPSRRSRSGSSPGLRDGSGTPSRHSLSG------SSPGMKDIPRTPSRGRSECDSSPEPK 1487
Query: 630 HASAFPRARRQGVS-------VLRKRYSEPVSLGSAQSPPLSPLALGIKEHELVTGLAQ- 681
PR R + S L + S S ++ LG + +G +Q
Sbjct: 1488 ALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSR---SGSSQE 1544
Query: 682 FNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSASSSSLTPMGRDALGSLSPALED 741
+++ S +E S+ SD SP R P + S S + D+ LSP
Sbjct: 1545 LDVKPSASPQERSE---SDSSPDSKAKT--RTPLRQRSRSGSSPEV--DSKSRLSPRRSR 1597
Query: 742 GKAAP---DEPGSAALGSVGS-SDPENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGD 797
++P D+P +A GS S PE K P P +L G+ S+ RG
Sbjct: 1598 SGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPR---------ALPRRSRSGSSSKGRGPS 1648
Query: 798 PEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDS-EPSCKGGLPRDKPTKR 856
PE G S S+P P S S EP K P + + R
Sbjct: 1649 PE----------------GSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSR 1692
Query: 857 KDVVAPKRGSLKEASPGASK--------PGSARRSQGAVAKSVRTLTASENESMRKVMPI 908
++ L S AS P RRS + + S P
Sbjct: 1693 SSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPR 1752
Query: 909 TKSSRGAGWRRPELSSRG----PSQNPPSSTDTVWSRQNSVRRASTGAEEQRLP------ 958
TK++ G R P RG S++ T T R S ST QR
Sbjct: 1753 TKTTSRRG-RSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVT 1811
Query: 959 ---RGSSGSSSTRPGRDVPLQP-----RGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGP 1010
RG SG S P R + RG + P R+ R P K R+ +
Sbjct: 1812 RRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPA 1871
Query: 1011 ESPKEEPKTPSVP-----SVPHELPRVPSFARNTVAS----------SSRSMRTDLPPVA 1055
+ +TP + S + R S +R +V S R R+ PPV
Sbjct: 1872 THRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVT 1931
Query: 1056 KAPGITRTVSQRQLRVKGDPEDAAPKDSS-----TLRRASSARAP--KKRPESAEGP--- 1105
+ +RT + R+ P + S T RR+ S +P ++R S P
Sbjct: 1932 RRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTR 1991
Query: 1106 --SANTEAPLKARGAGERAS--LRRKDSSRT 1132
S + +P+ R + R S RR+ SRT
Sbjct: 1992 RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRT 2022
Score = 59.3 bits (142), Expect = 2e-08
Identities = 155/661 (23%), Positives = 234/661 (35%), Gaps = 98/661 (14%)
Query: 534 PNTRRSRLSLGPSA-DRELLTFLESSTGSPEEP--NKFHSLPRSSPRQARPTIACLEPAE 590
P T+ +L S+ D EL+ +E S EEP L + E
Sbjct: 1220 PETKEQNSALPTSSQDEELMEVVEKS----EEPAGQILSHLSSELKEMSTSNFESSPEVE 1275
Query: 591 VRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLAAAQPEN-HASAFPRARRQGVSVLRKRY 649
R S + Q+ E P A + PE+ S P S L R
Sbjct: 1276 ERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRN 1335
Query: 650 SEPVSLGSAQSPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQLTL----SDFSPME 705
S P LG+ + S +KE L Q S M+E S + S+ SP
Sbjct: 1336 SGP--LGTEMNTGFSS---EVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDA 1390
Query: 706 LESVGHRGPQSLSA--------------SSSSLTPMGRDAL---------GSLSPALEDG 742
+E G QS+S+ SSS+ +P +D L SP L DG
Sbjct: 1391 VEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDG 1450
Query: 743 KAAPDEPGSAALGSVGSSDPENKD-PRPLFCISDTTDCSLTLDCSEGTDSRPRGGDPEEG 801
P S+ S P KD PR D S T RPR P
Sbjct: 1451 SGTPSRH------SLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTP-RPRSRSPS-- 1501
Query: 802 GEGDGSMSSGVGEMGDSQVSSNPTSSPPGE-APAPVSVDSEPSCKGGL-PRDKPTKRKDV 859
S +N +P E + + SVD + + L R + +++
Sbjct: 1502 ----------------SPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQEL 1545
Query: 860 VAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKSSRGAGWR- 918
S +E S S P S +++ + + R+ ++ E +S ++ P +S G+
Sbjct: 1546 DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSP-RRSRSGSSPEV 1604
Query: 919 --RPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQ 976
+P + R S + S + + RR+ +G+ + GSSST + P +
Sbjct: 1605 KDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPK 1664
Query: 977 P----RGSFKKPSAK------PLRNLPRQKPE------ENKTCRAHSEGPE----SPKEE 1016
RGS P K P R R PE ++ R+ S PE +P
Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRH 1724
Query: 1017 PKTPSVPSVPHELPRVPSFARNTVASSSRSMRTD---LPPVAKAPGI--TRTVSQRQLRV 1071
++PSV S P + S R ASS R+ T P K G+ +R+ S+R+
Sbjct: 1725 RRSPSVSS-PEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTR 1783
Query: 1072 KGDPEDAAPKDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSR 1131
D + ST RR +R+ + G S + + +S RR+ SR
Sbjct: 1784 TTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSR 1843
Query: 1132 T 1132
T
Sbjct: 1844 T 1844
Score = 57.0 bits (136), Expect = 1e-07
Identities = 149/716 (20%), Positives = 242/716 (33%), Gaps = 121/716 (16%)
Query: 457 NKAVKDNHDREAQELR--QLQRLKEQEQKQRSWATGELGAFGRSSSENDVELLTKKGAEG 514
N + D+ + ELR +L+ + E++ + ++ F E DV K+ G
Sbjct: 54 NPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPG 113
Query: 515 LLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPE----------- 563
P + + R R + G S ++++ S+ P+
Sbjct: 114 QRPAVTE---THQLAELNEKKNERLRAAFGISD-----SYVDGSSFDPQRRAREAKQPAP 165
Query: 564 EPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLA 623
EP K +SL R S PT + + + + ++S + E + H+
Sbjct: 166 EPPKPYSLVRESSSSRSPT----PKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE 221
Query: 624 A-AQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQSPPLSPLALGIKEHELVTGLAQF 682
+ ++ H S P+++R+ RKR S +P + H +
Sbjct: 222 SESKKRKHRSPTPKSKRKSKDKKRKR-----------SRSTTPAPKSRRAHRSTSA---- 266
Query: 683 NLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSASSSSLTPMGRDALGSLSPALEDG 742
+ SD S S + + A S GR G +P E G
Sbjct: 267 -----------DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGD-APFSEPG 314
Query: 743 KAAPDEPGSAALGSVGSSDP-ENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGDPEEG 801
+ P S + S P E+KD D + S T S + G +P
Sbjct: 315 TTSTQRPSSPETATKQPSSPYEDKD-------KDKKEKSATRP-SPSPERSSTGPEPPAP 366
Query: 802 ----GEGDGSMSSGVGEMGDSQVSSNPTS--SPPGEAPAPVSVDSEP---SCKGGLPRDK 852
E G + SQ NP S SP + P S + P S + P +
Sbjct: 367 TPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQ 426
Query: 853 PTKRKDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKSS 912
PTK V+ S E+ A PGS R + R+ ++ + P +
Sbjct: 427 PTK----VSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMG 482
Query: 913 RGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRD 972
R R P + RG S+ S T T G R P+ S+ R GR
Sbjct: 483 RS---RSPATAKRGRSR---SRTPT-----------KRGHSRSRSPQWRRSRSAQRWGRS 525
Query: 973 VPLQPRG---SFKKPSAKPLRNLPRQ-KPEENKTCRAHSEGPESP-KEEPKTPSVPSVPH 1027
Q RG S ++P RN R+ + + R+HS P + + +TP+
Sbjct: 526 RSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPA------ 579
Query: 1028 ELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLR 1087
R S +R SRS RT ++R+ R + + + R
Sbjct: 580 --RRGRSRSRTPARRRSRS---------------RTPTRRRSRSRTPARRGRSRSRTPAR 622
Query: 1088 RASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNPLRK 1143
R S R+P +R + P A ++R R R + +R R P R+
Sbjct: 623 RRSRTRSPVRRRSRSRSP-ARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARR 677
Score = 54.3 bits (129), Expect = 6e-07
Identities = 161/732 (21%), Positives = 260/732 (35%), Gaps = 145/732 (19%)
Query: 526 PSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQARPTIAC 585
P S PP SR S + +++ + S P+ R++PR++R C
Sbjct: 897 PRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPC 956
Query: 586 LEPAEVRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLAAAQPENHASAFPRARRQ---GV 642
E R ++H +S + P P Q+H S +P+ + Q G
Sbjct: 957 SN-VESRLLPR-YSHSGSSSPDTKVKPETPPRQSHS-------GSISPYPKVKAQTPPGP 1007
Query: 643 SVLRKRYSEPVSLGS---AQSPPLS-PLALGIKEHELVTGLAQFNLQGSQ--GMEETSQL 696
S+ + P QS P S L G+K G + F + Q G +TS
Sbjct: 1008 SLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKS-STPPGESYFGVSSLQLKGQSQTSPD 1066
Query: 697 TLSDFSPME----------LESVGHRGPQS-LSASSSSLTPMG-----RDALG--SLSPA 738
SD S E L+S P+ S SSS +T + R G S SP
Sbjct: 1067 HRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPM 1126
Query: 739 LEDGKAA------------PDEPGSAALGS-------------------VGSSDPENKDP 767
L+ G + P ++ LG +S P KD
Sbjct: 1127 LKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDK 1186
Query: 768 RPLFCISDTTDCSLTLDCSEGTDSRPRGG-----------------------------DP 798
F + D + SL + T R R G
Sbjct: 1187 FSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSE 1246
Query: 799 EEGGEGDGSMSSGVGEMGDSQVSSNP------------TSSPPGEAPAPVSVDSEPSCKG 846
E G+ +SS + EM S S+P S + V V S S G
Sbjct: 1247 EPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWG 1306
Query: 847 GLPRDKPTKRKDVVAPKRGS-------LKEASPGASKPGSARRSQGAVAKSVRTLTASEN 899
G P P ++ +P R + + + P ++ + S+ V + + ++
Sbjct: 1307 G-PHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSE--VKEDLNGPFLNQL 1363
Query: 900 ESMRKVMPITKSSRGAGWRRPELS-----SRGPSQNPPSST---DTVWSRQNSVRRASTG 951
E+ + +S+R +G ELS G S N S+ D V + R +S
Sbjct: 1364 ETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSAS 1423
Query: 952 AEEQR--LPRGSS--GSSSTRPG-RDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAH 1006
+ E + LPR S S + PG RD P S+ ++++PR C +
Sbjct: 1424 SPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSS 1483
Query: 1007 SEG---PESPKEEPKTPSVPSVPHELPRVPSFARNTVASSSRSMRTDLPPVAKAP--GIT 1061
E P++P+ ++PS P + ++ P R+ SS D VA+ P +
Sbjct: 1484 PEPKALPQTPRPRSRSPSSPELNNKC-LTPQRERSGSESS-----VDQKTVARTPLGQRS 1537
Query: 1062 RTVSQRQLRVK--GDPEDAAPKDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAG 1119
R+ S ++L VK P++ + DSS +A + ++R S P ++++ L R +
Sbjct: 1538 RSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR 1597
Query: 1120 ERASLRRKDSSR 1131
+S KD R
Sbjct: 1598 SGSSPEVKDKPR 1609
Score = 54.3 bits (129), Expect = 6e-07
Identities = 113/506 (22%), Positives = 178/506 (35%), Gaps = 64/506 (12%)
Query: 523 PISPSSPSYRPPNTRR----SRLSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQ 578
P +P++P+ R + LSL S SS+ +P+ P + + S
Sbjct: 2287 PRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHA 2346
Query: 579 ARP-------TIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPP-SAQAHQLAAAQP--- 627
P T A L PA + +S P SG +P P SA P
Sbjct: 2347 TAPVNIAGSRTAAALAPASL----TSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLL 2402
Query: 628 ENHASAFPRARRQGVSVLRKRYSEPVS-LGSAQSPPLSPLALGIKEHELVTGLAQFNLQG 686
+ S P + + +R P S +G A S L P A + + +
Sbjct: 2403 DRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFS------ 2456
Query: 687 SQGMEETSQLTLSDFSPMELESVGHRGPQSLSASS-SSLTPMGRDALGSLSPALEDGKAA 745
+ S+ ++ +P+ G QSLS+ + ++ T D G LS A
Sbjct: 2457 -----DQSRCLIAQTTPVA-------GSQSLSSGAVATTTSSAGDHNGMLSVP------A 2498
Query: 746 PDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGDPEEGGEGD 805
P P S S+ + P L + + + S + S
Sbjct: 2499 PGVPHSDVGEPPASTGAQQ--PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556
Query: 806 GSMSSGVGEMGDSQVSSNPTSSPPG--EAPAPVSVDSEPSCKGGLPRDKPTKRKDVVAPK 863
GS SS DS+ SS P P+P E +G P P KRK +
Sbjct: 2557 GSSSS------DSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSS 2610
Query: 864 RGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKS-SRGAGWRRP-- 920
S +S +S S+ S + + S + ++S + S P ++ + A ++P
Sbjct: 2611 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPP 2670
Query: 921 -ELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRG 979
E SR P + S D+ + V R + PR SSS R R RG
Sbjct: 2671 GERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPS--PRDQQSSSSERGSRR---GQRG 2725
Query: 980 SFKKPSAKPLRNLPRQKPEENKTCRA 1005
+ PS K R P +P +++ R+
Sbjct: 2726 DSRSPSHKRRRETPSPRPMRHRSSRS 2751
Score = 48.5 bits (114), Expect = 4e-05
Identities = 76/319 (23%), Positives = 115/319 (36%), Gaps = 44/319 (13%)
Query: 818 SQVSSNPTSSPPGEAPAPVSVDSE---PSCKGGLPRDK-----PTKRKDVVAPKRGSLKE 869
S+ SS+P + P+ S S P K G P + P + V P+R S E
Sbjct: 815 SRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFE 874
Query: 870 ASPGA---SKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKSSRGAGWRRPELSSRG 926
+SP S+ S G+ V++ T R P K R + S G
Sbjct: 875 SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPR--QRSHSG 932
Query: 927 PSQNPPS--STDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKP 984
S PS ++ T R SV S E + LPR S SS+ + P P
Sbjct: 933 SSSPSPSRVTSRTTPRRSRSVSPCSN-VESRLLPRYSHSGSSSPDTKVKPETPPRQSHSG 991
Query: 985 SAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTPSVPSVPHELPRVPSFARNTVASSS 1044
S P + Q P + S P+E+ K V S P L S
Sbjct: 992 SISPYPKVKAQTPPGPSLSGSKS---PCPQEKSKDSLVQSCPGSL------------SLC 1036
Query: 1045 RSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLRRASSARAPKKRPESAEG 1104
+++ PP G++ L++KG + + S T +P+ R +E
Sbjct: 1037 AGVKSSTPPGESYFGVS------SLQLKGQSQTSPDHRSDT-------SSPEVRQSHSES 1083
Query: 1105 PSANTEAPLKARGAGERAS 1123
PS +++ +G R+S
Sbjct: 1084 PSLQSKSQTSPKGGRSRSS 1102
Score = 42.0 bits (97), Expect = 0.003
Identities = 97/455 (21%), Positives = 162/455 (35%), Gaps = 46/455 (10%)
Query: 614 PPSAQAHQLAAAQPENHASAFPRARRQGVSVLRKRYSEPVSL-GSAQSPPLSPLALGIKE 672
PP+A + ++ P+ ASA R + + PV++ GS + L+P +L
Sbjct: 2317 PPTAANYPSSSRTPQAPASANLVGPRSAHA------TAPVNIAGSRTAAALAPASL--TS 2368
Query: 673 HELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSASS---SSLTPMGR 729
+ L+ NL + + SP L+ R P S + S S P
Sbjct: 2369 ARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPS 2428
Query: 730 DALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGT 789
+G +P+ A D+P S P + I+ TT + + S G
Sbjct: 2429 SRMGQ-APSQSLLPPAQDQPRSPV--------PSAFSDQSRCLIAQTTPVAGSQSLSSGA 2479
Query: 790 DSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDSEPSCKGGLP 849
+ G+ +G +S + S V P S+ + A ++ +P+ +
Sbjct: 2480 VATTTSS----AGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAAL--QPAKERRSS 2533
Query: 850 RDKPTKRKDVVAPKRGSLKEASPGASKP---GSARRSQGAVA-KSVRTLTASENESMRKV 905
+ + S +S G+S GS+ Q VA K V + T + E++R+
Sbjct: 2534 SSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREG 2593
Query: 906 MPITKSSRGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSS 965
P + R+ SS S + SS+ + S +S +S+ + SS S
Sbjct: 2594 RPPEPTPAK---RKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPS 2650
Query: 966 STRPGRDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGP---ESPKEEPKTPSV 1022
+PG +P K P + PR+ + + R+ S P P +P
Sbjct: 2651 PAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQ 2710
Query: 1023 PSVPHEL---------PRVPSFARNTVASSSRSMR 1048
S E R PS R S R MR
Sbjct: 2711 QSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMR 2745
Score = 38.5 bits (88), Expect = 0.037
Identities = 109/542 (20%), Positives = 188/542 (34%), Gaps = 97/542 (17%)
Query: 614 PPSAQAHQLAAAQPENHASAFPRARRQG-----VSVLRKRYSEPVSLGSAQSPPLSPLAL 668
PPS A LAA + A + R S + + ++L SA++P + P A+
Sbjct: 2196 PPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAI-PTAV 2254
Query: 669 GIKEHELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESV---GHRGPQSLSA------ 719
+ + A NL + S + L+D +V G R P +L+A
Sbjct: 2255 NLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGS 2314
Query: 720 ---------SSSSLTPMGRDALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPL 770
SSS TP + + P A + GS ++ + + P
Sbjct: 2315 GTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPA 2374
Query: 771 FCISDTTDCSLTLDCSEGTDSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPG 830
++ T + L E R + D S P S+P
Sbjct: 2375 LSGANLTSPRVPLSAYERVSGRTSP------------------PLLDRARSRTPPSAPSQ 2416
Query: 831 E------APAPVSVDSEPSCKGGLPRDKPTKRKDVVAP----KRGSLKEASPGASKPGSA 880
AP+P S + + LP + R V + R + + +P A GS
Sbjct: 2417 SRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVA---GSQ 2473
Query: 881 RRSQGAVAKSVRTLTASENESMRKV-------MPITKSSRGAGWRRPE-LSSRGPSQNPP 932
S GAVA + T +A ++ M V + + G ++P L++ P++
Sbjct: 2474 SLSSGAVATT--TSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERR 2531
Query: 933 SSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKK-PSAKPLRN 991
SS+ + S +S +S+ + S SSS G +P+QP + K+ PS P
Sbjct: 2532 SSSSSSSSSSSSSSSSSSSSSSS----SSGSSSSDSEGSSLPVQPEVALKRVPSPTPA-- 2585
Query: 992 LPRQKPEENKTCRAHSEGPESPKEEPKTPSVPSVPHELPRVPSFARNTVASSSRSMRTDL 1051
P++ E + PE + K R++ +SSS S +
Sbjct: 2586 -PKEAVREGRP-------PEPTPAKRKR-----------------RSSSSSSSSSSSSSS 2620
Query: 1052 PPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLRRASSARAPKKRPESAEGPSANTEA 1111
+ + + + S ++P + +A A K+P E S +
Sbjct: 2621 SSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRK 2680
Query: 1112 PL 1113
P+
Sbjct: 2681 PI 2682
Score = 32.3 bits (72), Expect = 2.6
Identities = 29/86 (33%), Positives = 38/86 (44%), Gaps = 22/86 (25%)
Query: 9 LVSDKENGN---IATAPGFMIGQTP--PPAPPPP-----PPPPPPSPPCSCSREECPSSP 58
L++++ G+ +AT P + Q P PP+ P PP P P S S E SSP
Sbjct: 369 LLAERHGGSPQPLATTP---LSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSE---SSP 422
Query: 59 PPPPPPPL------PGEPPIPPPPPG 78
P P P + E P P P PG
Sbjct: 423 PSPQPTKVSRHASSSPESPKPAPAPG 448
Score = 32.3 bits (72), Expect = 2.6
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 28/136 (20%)
Query: 498 SSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLES 557
SSS + K G + L P+P SP P PP RRSR P + L S
Sbjct: 2642 SSSSSSSPSPAKPGPQAL-----PKPASPKKP---PPGERRSR---SPRKPIDSLRDSRS 2690
Query: 558 STGSPEEPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPPSA 617
+ SP E + P+ SPR Q SS + + G + ++ +P
Sbjct: 2691 LSYSPVERRR--PSPQPSPRD---------------QQSSSSERGSRRGQRGDSRSPSHK 2733
Query: 618 QAHQLAAAQPENHASA 633
+ + + +P H S+
Sbjct: 2734 RRRETPSPRPMRHRSS 2749
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 67.8 bits (164), Expect = 6e-11
Identities = 34/71 (47%), Positives = 40/71 (56%), Gaps = 6/71 (8%)
Query: 22 PGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPP 81
PGF + PPP PPPPPPPPP P + P+ P PPPP L PP+PP PPGL P
Sbjct: 701 PGFPM---PPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPIL---PPLPPFPPGLFP 754
Query: 82 TTHMNGYSHLG 92
++ LG
Sbjct: 755 VMQVDMSHVLG 765
Score = 64.3 bits (155), Expect = 6e-10
Identities = 35/77 (45%), Positives = 37/77 (48%), Gaps = 16/77 (20%)
Query: 21 APGFMIGQTPPPAPP--PPPPPPPPSPPCSCSREECPSSPPPP------------PPPPL 66
AP + P P PP PP PPPPP PP P PPPP PPPPL
Sbjct: 671 APSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPL 730
Query: 67 PGEPPIPPPP--PGLPP 81
P P +PPPP P LPP
Sbjct: 731 PAPPGVPPPPILPPLPP 747
Score = 58.9 bits (141), Expect = 3e-08
Identities = 29/54 (53%), Positives = 29/54 (53%), Gaps = 12/54 (22%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTT 83
PPP PP PPPPPP PP P P PPPLP PP PPPPP P T
Sbjct: 683 PPPGFPPLPPPPPPPPP----------QPGFPMPPPLP--PPPPPPPPAHPAVT 724
Score = 43.9 bits (102), Expect = 9e-04
Identities = 42/153 (27%), Positives = 61/153 (39%), Gaps = 20/153 (13%)
Query: 21 APGFMIGQTPPPAPPP--PPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPI----PP 74
APGF +P P PPPP P+ + + P PPPLP P+ P
Sbjct: 390 APGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPG 449
Query: 75 PPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTI 134
PPG PP N G+ +F W P + T + A ++ H +D++ I
Sbjct: 450 TPPG-PPPPDTNSMELGGRP----TFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSR-I 503
Query: 135 EELFGQQ--------EDTTKSSLPRRGRTLNSS 159
E L +Q E + + L G ++SS
Sbjct: 504 EMLLKEQRTKLLFLREPDSDTELQMEGSPISSS 536
Score = 43.9 bits (102), Expect = 9e-04
Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 32 PAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPT 82
P P P P P + + + ++ P PPPPLP +PP PPPPP + PT
Sbjct: 1510 PGQPQTPVFPSTHDPRTVTLD-FRNAGIPAPPPPLPPQPPPPPPPPPVEPT 1559
Score = 42.4 bits (98), Expect = 0.003
Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 3/53 (5%)
Query: 33 APPPPPPPPPPSPPCSCSR---EECPSSPPPPPPPPLPGEPPIPPPPPGLPPT 82
+P PP PP S R + P PP PLP +PP+PPP P PP+
Sbjct: 1240 SPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPS 1292
Score = 42.0 bits (97), Expect = 0.003
Identities = 20/47 (42%), Positives = 21/47 (44%), Gaps = 10/47 (21%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPP 76
P P PP PPP PP PP SPPP P P +PP P
Sbjct: 1275 PLPLQPPLPPPRPPRPP----------SPPPEPETTDASHPSVPPEP 1311
Score = 41.6 bits (96), Expect = 0.004
Identities = 25/58 (43%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 22 PGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGL 79
P M+ P PPP PP PPSPP E +S P PP PL + PP PGL
Sbjct: 1270 PPMMLPLPLQPPLPPPRPPRPPSPP--PEPETTDASHPSVPPEPLAEDH--PPHTPGL 1323
Score = 40.8 bits (94), Expect = 0.007
Identities = 19/40 (47%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 30 PPPAPP--PPPPPPPPSPPCSCSREECPSSPPPPPPPPLP 67
PPP PP PPPPPPPP P +E + P PP P
Sbjct: 1540 PPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGP 1579
Score = 40.4 bits (93), Expect = 0.010
Identities = 25/66 (37%), Positives = 26/66 (39%), Gaps = 17/66 (25%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPP----PPPPLPG----------EPPIPPP 75
PPP PP PP PPP S PS PP P PP PG +P
Sbjct: 1283 PPPRPPRPPSPPPEPETTDASH---PSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPAT 1339
Query: 76 PPGLPP 81
P G PP
Sbjct: 1340 PGGEPP 1345
Score = 40.0 bits (92), Expect = 0.013
Identities = 27/72 (37%), Positives = 29/72 (40%), Gaps = 13/72 (18%)
Query: 27 GQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPP---IPPPPPGLPPTT 83
G PP P PP PPPPP PP P P P L + P IPP P G T
Sbjct: 1535 GIPAPPPPLPPQPPPPPPPP--------PVEPTKLPFKELDNQWPSEAIPPGPRGRDEVT 1586
Query: 84 HMNGYSHLGKKK 95
Y L K +
Sbjct: 1587 --EEYMELAKSR 1596
Score = 37.7 bits (86), Expect = 0.063
Identities = 20/45 (44%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 35 PPPPPPPPPSPPCSCSREECPSSPPPPPP--PPLPGEPPIPPPPP 77
P P P + + P+ P PPPP PPLP PP PPPPP
Sbjct: 657 PKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLP--PPPPPPPP 699
Score = 37.0 bits (84), Expect = 0.11
Identities = 78/334 (23%), Positives = 108/334 (32%), Gaps = 55/334 (16%)
Query: 740 EDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGDPE 799
E+ AP P +LG D E + P S + L + E DSR +P
Sbjct: 1171 EEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPG 1230
Query: 800 EGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDSEPSCKGGLPRDKPTKRKDV 859
EG +S E +V + P SP + V+ EP LP P
Sbjct: 1231 LSQEGAMLLSP---EPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRP 1287
Query: 860 VAPKRGSLKEASPGASKPGSARRSQ------------GAVAKSVRTLTASENESMRKVMP 907
P + + AS P G++AKS T T P
Sbjct: 1288 PRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEP--P 1345
Query: 908 ITKSSRGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSST 967
++ S G P++ S PS P SSG
Sbjct: 1346 LSGGSSGLSLSSPQVPGSPFSYPAPS------------------------PSLSSGGLPR 1381
Query: 968 RPGRDVPLQPRGSFKKPSAK---PLRNLPRQKPEENKTCRAHSEGPESPKEEPKTPSVPS 1024
PGRD P +F +PS P+ LP + +E GP + +T +P
Sbjct: 1382 TPGRDFSFTP--TFSEPSGPLLLPVCPLPTGRRDER-------SGPLASPVLLET-GLP- 1430
Query: 1025 VPHELPRVPSFARNTVASSSRSMRTDLPPVAKAP 1058
+P LP A V + T LPP+ AP
Sbjct: 1431 LPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAP 1464
Score = 37.0 bits (84), Expect = 0.11
Identities = 24/66 (36%), Positives = 25/66 (37%), Gaps = 5/66 (7%)
Query: 23 GFMIGQTPPPAP-----PPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPP 77
G M+ PPA PP P P E P P PP P PP PP PP
Sbjct: 1235 GAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPP 1294
Query: 78 GLPPTT 83
P TT
Sbjct: 1295 PEPETT 1300
Score = 36.2 bits (82), Expect = 0.18
Identities = 17/45 (37%), Positives = 19/45 (42%)
Query: 36 PPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLP 80
P P P + + P PPPP P PP PPPPP P
Sbjct: 657 PKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQP 701
Score = 31.6 bits (70), Expect = 4.5
Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 17/54 (31%)
Query: 39 PPPPPSPPCSCSREECPSSPPP-------------PPPPPLPGEPPIPPPPPGL 79
P PP S P S E+ +P P P PPP PG PP P GL
Sbjct: 557 PTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPG----PPDPAGL 606
Score = 31.2 bits (69), Expect = 5.9
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 12 DKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSC-SREECPSSPPPPPPPPLPGEP 70
D+ +G +A+ ++ +T P P P P P P + P ++ P+ PP P PL P
Sbjct: 1413 DERSGPLASP---VLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCP 1469
Query: 71 PIPPPPPGLP 80
P PG P
Sbjct: 1470 PPMKRKPGRP 1479
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 67.4 bits (163), Expect = 7e-11
Identities = 40/104 (38%), Positives = 44/104 (42%), Gaps = 34/104 (32%)
Query: 18 IATAPGFMIGQTPPPAPPPPPPP----PPPSPPCSCSREECP--------------SSPP 59
+ + PG G PPPAPPPPPPP PPP PP P ++PP
Sbjct: 306 LGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPP 365
Query: 60 PPPPPP------LP----------GEPPIPPPPPGLPPTTHMNG 87
PPPPPP LP PP PPPPP PP G
Sbjct: 366 PPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTG 409
Score = 60.8 bits (146), Expect = 7e-09
Identities = 33/77 (42%), Positives = 38/77 (49%), Gaps = 25/77 (32%)
Query: 27 GQTPPPAPP----------PPPPPPPPS--------PPCSCSREECPSSPPPPPPPPLPG 68
G PPP+PP PPPPPPPP+ PP S + +PPPPPPPP PG
Sbjct: 345 GTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLS---QPTGGAPPPPPPPPPPG 401
Query: 69 EPPIP----PPPPGLPP 81
PP P P +PP
Sbjct: 402 PPPPPFTGADGQPAIPP 418
Score = 55.8 bits (133), Expect = 2e-07
Identities = 32/67 (47%), Positives = 34/67 (50%), Gaps = 24/67 (35%)
Query: 30 PPPAPPPPPPP-------PPPSPPCSCSREECPSSPP----PPPPPPL----PGEPPIPP 74
PPPAPP PP PPP+PP P PP PPPPPP+ PG PP PP
Sbjct: 300 PPPAPPLGSPPGPKPGFAPPPAPP--------PPPPPMIGIPPPPPPVGFGSPGTPP-PP 350
Query: 75 PPPGLPP 81
PP PP
Sbjct: 351 SPPSFPP 357
Score = 53.5 bits (127), Expect = 1e-06
Identities = 29/76 (38%), Positives = 36/76 (47%), Gaps = 12/76 (15%)
Query: 12 DKENGNIATAP--GFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGE 69
D + G+ P ++ + PP PP PP P P + P PPPPPPP+ G
Sbjct: 279 DNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFA------PPPAPPPPPPPMIGI 332
Query: 70 PPIPPP----PPGLPP 81
PP PPP PG PP
Sbjct: 333 PPPPPPVGFGSPGTPP 348
Score = 42.0 bits (97), Expect = 0.003
Identities = 34/115 (29%), Positives = 39/115 (33%), Gaps = 36/115 (31%)
Query: 14 ENGNIATAPGFMIGQTPPP-------APPP-------PPPPPPPSPPCSCSREE------ 53
+NG+I PPP +P P PPPP S P R
Sbjct: 231 QNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPK 290
Query: 54 -----CPSSPPPPPP-----------PPLPGEPPIPPPPPGLPPTTHMNGYSHLG 92
PS PPP PP P P PP PPP G+PP G+ G
Sbjct: 291 RSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPG 345
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 66.6 bits (161), Expect = 1e-10
Identities = 38/85 (44%), Positives = 39/85 (45%), Gaps = 31/85 (36%)
Query: 27 GQTPPP-------APPPPPP--------PPPPS----PPCSCSREECPSSPPP------- 60
G PPP APPPPPP PPPP+ PP PS PPP
Sbjct: 308 GAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLG 367
Query: 61 -----PPPPPLPGEPPIPPPPPGLP 80
PPPPP P PP PPPPPGLP
Sbjct: 368 VGPVAPPPPPPPPPPPGPPPPPGLP 392
Score = 60.8 bits (146), Expect = 7e-09
Identities = 34/92 (36%), Positives = 40/92 (43%), Gaps = 24/92 (26%)
Query: 13 KENGNIATAPGFMIGQTPPPAPP----PPPPPPPP--------------SPPCSCSREEC 54
++ G + + Q PPP PP PPPPPPPP +PP SR
Sbjct: 260 EKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPT 319
Query: 55 PSSPPPPPPPPLPGEPP------IPPPPPGLP 80
+ PPPPP P PP PPPPP LP
Sbjct: 320 AAPPPPPPSRPSVAVPPPPPNRMYPPPPPALP 351
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/54 (44%), Positives = 24/54 (44%), Gaps = 18/54 (33%)
Query: 36 PPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPP-------IPPPPPGLPPT 82
PPPPPP P PPPPPPP G PP PPPPP PT
Sbjct: 277 PPPPPPSRGGP-----------PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPT 319
Score = 45.4 bits (106), Expect = 3e-04
Identities = 21/52 (40%), Positives = 25/52 (48%), Gaps = 13/52 (25%)
Query: 22 PGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIP 73
P ++G P PPPPPPPPPP PPPPP P G+ +P
Sbjct: 362 PPSVLGVGPVAPPPPPPPPPPP-------------GPPPPPGLPSDGDHQVP 400
Score = 37.7 bits (86), Expect = 0.063
Identities = 17/33 (51%), Positives = 18/33 (54%), Gaps = 2/33 (6%)
Query: 51 REECPSSPPPPPPPPLPGEPPIPPPP--PGLPP 81
+ E PPPPPP G PP PPPP G PP
Sbjct: 269 KNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPP 301
>gi|148613878 acrosin precursor [Homo sapiens]
Length = 421
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/102 (39%), Positives = 52/102 (50%), Gaps = 14/102 (13%)
Query: 36 PPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKK 95
PPP P PP PP + R P SPPPPPPPP PP PPPPP P +T L K
Sbjct: 330 PPPRPLPPRPPAAQPRP--PPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQG-LSFAK 386
Query: 96 RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEEL 137
R++ E ++GKT + ++HY ++T + EL
Sbjct: 387 RLQQLI------EVLKGKT-----YSDGKNHYDMETTELPEL 417
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 65.9 bits (159), Expect = 2e-10
Identities = 35/63 (55%), Positives = 36/63 (57%), Gaps = 5/63 (7%)
Query: 20 TAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPP-PPPLPGEPPIPPPPPG 78
T P Q PP PPPPP P PSPP + PSSPPPPP PPP P P PPPPP
Sbjct: 1460 TPPPAPTPQPQPPPPPPPPQPALPSPPPLVA--PTPSSPPPPPLPPPPPPAMPSPPPPP- 1516
Query: 79 LPP 81
PP
Sbjct: 1517 -PP 1518
Score = 62.4 bits (150), Expect = 2e-09
Identities = 27/52 (51%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPP-PPPPPPLPGEPPIPPPPPGLP 80
PPP PPPP P P PP P PP PPPPPP PP PPPP P
Sbjct: 1471 PPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAP 1522
Score = 60.5 bits (145), Expect = 9e-09
Identities = 28/63 (44%), Positives = 32/63 (50%), Gaps = 17/63 (26%)
Query: 25 MIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPI------PPPPPG 78
++ + PPP PPP P P P PP PPPPP P LP PP+ PPPP
Sbjct: 1452 LLEEKPPPTPPPAPTPQPQPPP-----------PPPPPQPALPSPPPLVAPTPSSPPPPP 1500
Query: 79 LPP 81
LPP
Sbjct: 1501 LPP 1503
Score = 56.2 bits (134), Expect = 2e-07
Identities = 43/123 (34%), Positives = 54/123 (43%), Gaps = 22/123 (17%)
Query: 21 APGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPP--PPL---PGEPPIP-P 74
+P ++ TP PPPP PPPPP PS PPPPPP PL P EP P P
Sbjct: 1484 SPPPLVAPTPSSPPPPPLPPPPP--------PAMPSPPPPPPPAAAPLAAPPEEPAAPSP 1535
Query: 75 PPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTI 134
P LP T + HL KK+ + +T E G I+ R+ + I + I
Sbjct: 1536 EDPELPDTRPL----HLAKKQETAAVCGETDEEAGESGGEGIF----RERDEFVIRAEDI 1587
Query: 135 EEL 137
L
Sbjct: 1588 PSL 1590
Score = 52.0 bits (123), Expect = 3e-06
Identities = 23/51 (45%), Positives = 28/51 (54%), Gaps = 6/51 (11%)
Query: 32 PAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPT 82
P PP PPP+PP P+ P PPPPP P +P +P PPP + PT
Sbjct: 1448 PEPPLLEEKPPPTPP------PAPTPQPQPPPPPPPPQPALPSPPPLVAPT 1492
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/62 (46%), Positives = 30/62 (48%), Gaps = 11/62 (17%)
Query: 30 PPPAPPPPPPPPPPSP--PCSCSR--------EECPSSPPPPPPPPLPGEPPIPPPP-PG 78
PP AP P PPP P P + S EE P PPP P P P PP PPPP P
Sbjct: 1422 PPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPA 1481
Query: 79 LP 80
LP
Sbjct: 1482 LP 1483
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/96 (29%), Positives = 35/96 (36%), Gaps = 35/96 (36%)
Query: 16 GNIATAPGFMIGQTPPPAPPPPPPPPPP-------------SPPCSCSREECP------- 55
G + G QTPP P PP PPPPP S + + + P
Sbjct: 211 GGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSG 270
Query: 56 SSPPPPPPP---------------PLPGEPPIPPPP 76
++P PPPP P +PP PPPP
Sbjct: 271 AAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPP 306
Score = 41.2 bits (95), Expect = 0.006
Identities = 19/45 (42%), Positives = 21/45 (46%)
Query: 31 PPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPP 75
P PPPPPPPPPP P + P P P L E + PP
Sbjct: 833 PQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPP 877
Score = 40.8 bits (94), Expect = 0.007
Identities = 29/97 (29%), Positives = 34/97 (35%), Gaps = 22/97 (22%)
Query: 20 TAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPS------------------SPPPP 61
T G ++ P P PPPPP P S PS +P PP
Sbjct: 777 TPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPP 836
Query: 62 PPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMR 98
PPPP PP PP P L +G R+R
Sbjct: 837 PPPP----PPPPPMPLQLEAHLRSHGLEPAAPSPRLR 869
Score = 40.0 bits (92), Expect = 0.013
Identities = 25/77 (32%), Positives = 27/77 (35%), Gaps = 23/77 (29%)
Query: 22 PGFMIGQTPPPAPPPPPPPPPP------------SPPCSCSREECPSSPPPP-------- 61
P G PP PPPPPPPP P P R S PP
Sbjct: 826 PATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLG 885
Query: 62 ---PPPPLPGEPPIPPP 75
P PP PG+ + PP
Sbjct: 886 ALEPLPPAPGDTGVGPP 902
Score = 39.7 bits (91), Expect = 0.017
Identities = 38/145 (26%), Positives = 54/145 (37%), Gaps = 31/145 (21%)
Query: 27 GQTPPPAPPPPPPPPPPSP-PCSCSREECPS-SPPPPPPPPLPG---------------- 68
G PPP PP P P P S + E P P PP LP
Sbjct: 977 GAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQ 1036
Query: 69 ---EPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEH 125
PP PPPPP P + G + F T P++ + KT+ + L R++
Sbjct: 1037 AAPPPPPPPPPPPAPASEPKGGLT--------SPIFCSTKPKKLL--KTSSFHLLRRRDP 1086
Query: 126 HYQIDTKTIEELFGQQEDTTKSSLP 150
+Q K + + + D K+ +P
Sbjct: 1087 PFQTPKKLYAQEYEFEADEDKADVP 1111
Score = 38.9 bits (89), Expect = 0.028
Identities = 28/91 (30%), Positives = 31/91 (34%), Gaps = 49/91 (53%)
Query: 28 QTPPPAPPP-------------------------PPPP-----------PPPSPPCS--- 48
Q PP PPP PPPP P PSP S
Sbjct: 761 QKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVG 820
Query: 49 ------CSREECPSSPPPPPPPPLPGEPPIP 73
+R+ P PPPPPPPP PP+P
Sbjct: 821 VHLLEPATRDGAPQPPPPPPPPP----PPMP 847
Score = 38.9 bits (89), Expect = 0.028
Identities = 27/92 (29%), Positives = 31/92 (33%), Gaps = 33/92 (35%)
Query: 33 APPPPPP------PPPPSPPCSCSREECPSSPPPPPPPPLP------------------- 67
+PPPPPP P P + P PPPPP LP
Sbjct: 763 SPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVH 822
Query: 68 --------GEPPIPPPPPGLPPTTHMNGYSHL 91
G P PPPPP PP + +HL
Sbjct: 823 LLEPATRDGAPQPPPPPPPPPPPMPLQLEAHL 854
Score = 38.5 bits (88), Expect = 0.037
Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 11/153 (7%)
Query: 820 VSSNPTSSPPGEAPAPVSVDSEPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGS 879
VS+ +S+PP +APAP +P +KP ++ A E P +P
Sbjct: 1684 VSAGGSSAPPPKAPAP---PPKPETPEKTTSEKPPEQTPETAMPEPPAPE-KPSLLRPVE 1739
Query: 880 ARRSQGAVAKSVRTLTASENESMRKVMPITKSSRG--AGWRRPELSSRGPSQNPPSSTDT 937
+ + V + R L S R+ P + G A R P+ PP
Sbjct: 1740 KEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRK 1799
Query: 938 VWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPG 970
W ++ + G P GSS S + PG
Sbjct: 1800 KWLKEAGGNATAGGG-----PPGSSSDSESSPG 1827
Score = 38.1 bits (87), Expect = 0.048
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 5/55 (9%)
Query: 27 GQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPP 81
G + PP P PPP P +P + S + PP P EPP P P L P
Sbjct: 1688 GSSAPPPKAPAPPPKPETPEKTTSEK-----PPEQTPETAMPEPPAPEKPSLLRP 1737
Score = 37.4 bits (85), Expect = 0.082
Identities = 69/326 (21%), Positives = 107/326 (32%), Gaps = 57/326 (17%)
Query: 823 NPTSSPP---GEAPAPVSVDSEPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGS 879
NP P G P D P +G PR +P + P S + GA KP
Sbjct: 1146 NPGPDGPRRRGRKPTKAKRDGPPRPRGR-PRIRPLEVPTTAGP--ASASTPTDGAKKPRG 1202
Query: 880 ARRSQGAVAKSVRTLTASENESMRKVMPITKSSRGAGWRRPELSSRGPSQNPPSSTDTVW 939
R +G A+ + ++ + + K+ G G + S G N S+ T
Sbjct: 1203 RGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAIS-GTDHNSLDSSLTRE 1261
Query: 940 SRQNSVRRASTGAEEQRLPRGSSGSSSTRPG-RDVPLQPRGSFKKPSAKPLRNLPRQKPE 998
+ ++ E + +S + G R PL G P P +++P P
Sbjct: 1262 KIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGL--TPPLSPPKSVPPSVPA 1319
Query: 999 ENKTCRAHSEGPESPKEEPKTPSVPSVPHELPR--------------------VPSFARN 1038
+P+ P+ P+VPH P PS +
Sbjct: 1320 RGL--------------QPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKR 1365
Query: 1039 TVASSSRSMRT-------DLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSST-----L 1086
R++ T + VAK + ++S + DP A PKD+ST L
Sbjct: 1366 LDEELKRNLETLPSFSSDEEDSVAKNRDLQESISS-AISALDDPPLAGPKDTSTPDGPPL 1424
Query: 1087 RRASSARAPKKRPESAEGPSANTEAP 1112
A++ P P S T P
Sbjct: 1425 APAAAVPGPPPLPGLPSANSNGTPEP 1450
Score = 34.7 bits (78), Expect = 0.53
Identities = 37/158 (23%), Positives = 57/158 (36%), Gaps = 14/158 (8%)
Query: 974 PLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTPSVPSV-------- 1025
P+ GS P P + PE+ + + + PE+ EP P PS+
Sbjct: 1683 PVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKEK 1742
Query: 1026 -PHELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSS 1084
++ R R A+S R R + P +R R +VK +P K
Sbjct: 1743 EKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEP--PPKKRKK 1800
Query: 1085 TLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERA 1122
L+ A P G S+++E+ A ERA
Sbjct: 1801 WLKEAGGNATAGGGP---PGSSSDSESSPGAPSEDERA 1835
Score = 34.3 bits (77), Expect = 0.70
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Query: 22 PGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPP 65
P + G TPP +PP PPS P + + P++P P PPP
Sbjct: 1297 PLYQAGLTPPLSPP---KSVPPSVPARGLQPQPPATPAVPHPPP 1337
Score = 31.6 bits (70), Expect = 4.5
Identities = 24/79 (30%), Positives = 28/79 (35%), Gaps = 18/79 (22%)
Query: 22 PGFMIGQTPPPAPPPP-----------PPPPPPSPPCSCSREEC-------PSSPPPPPP 63
P + Q PP +PP P P+ P S E P+ P
Sbjct: 165 PSSLSLQDPPFSPPANGLLSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLGPAGLGPAQT 224
Query: 64 PPLPGEPPIPPPPPGLPPT 82
PP PP PPPPP PT
Sbjct: 225 PPYRPGPPDPPPPPRHLPT 243
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,361,459
Number of Sequences: 37866
Number of extensions: 3802147
Number of successful extensions: 101237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1216
Number of HSP's successfully gapped in prelim test: 1222
Number of HSP's that attempted gapping in prelim test: 31655
Number of HSP's gapped (non-prelim): 32884
length of query: 1143
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1030
effective length of database: 13,968,660
effective search space: 14387719800
effective search space used: 14387719800
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.