Search of human proteins with 109633041

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109633041 protein tyrosine phosphatase, receptor type, F
isoform 1 precursor [Homo sapiens]
         (1907 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109633041 protein tyrosine phosphatase, receptor type, F isof...  3859   0.0  
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...  3830   0.0  
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...  2716   0.0  
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...  2703   0.0  
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...  2689   0.0  
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...  2564   0.0  
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...  2555   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...  1449   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...  1444   0.0  
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...  1407   0.0  
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...  1407   0.0  
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   609   e-174
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   609   e-174
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   609   e-174
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   566   e-161
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   551   e-156
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   510   e-144
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   506   e-143
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   504   e-142
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   499   e-141
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   496   e-140
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   464   e-130
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   461   e-129
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   458   e-128
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   446   e-124
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   422   e-117
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110

>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score = 3859 bits (10007), Expect = 0.0
 Identities = 1907/1907 (100%), Positives = 1907/1907 (100%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
            NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS
Sbjct: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240

Query: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
            QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
Sbjct: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300

Query: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
            ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360

Query: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
            GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
            QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP
Sbjct: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480

Query: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
            GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI
Sbjct: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540

Query: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
            IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR
Sbjct: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600

Query: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
            TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD
Sbjct: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660

Query: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
            GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL
Sbjct: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720

Query: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780
            NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY
Sbjct: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780

Query: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 840
            ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW
Sbjct: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 840

Query: 841  HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 900
            HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL
Sbjct: 841  HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 900

Query: 901  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS 960
            GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS
Sbjct: 901  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS 960

Query: 961  QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1020
            QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV
Sbjct: 961  QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1020

Query: 1021 AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR 1080
            AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR
Sbjct: 1021 AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR 1080

Query: 1081 GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID 1140
            GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID
Sbjct: 1081 GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID 1140

Query: 1141 RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL 1200
            RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL
Sbjct: 1141 RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL 1200

Query: 1201 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1260
            GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE
Sbjct: 1201 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1260

Query: 1261 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1320
            MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN
Sbjct: 1261 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1320

Query: 1321 YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR 1380
            YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR
Sbjct: 1321 YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR 1380

Query: 1381 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE 1440
            YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE
Sbjct: 1381 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE 1440

Query: 1441 QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS 1500
            QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS
Sbjct: 1441 QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS 1500

Query: 1501 SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560
            SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV
Sbjct: 1501 SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560

Query: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL 1620
            IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL
Sbjct: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL 1620

Query: 1621 YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR 1680
            YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR
Sbjct: 1621 YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR 1680

Query: 1681 VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK 1740
            VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK
Sbjct: 1681 VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK 1740

Query: 1741 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1800
            LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF
Sbjct: 1741 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1800

Query: 1801 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR 1860
            TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR
Sbjct: 1801 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR 1860

Query: 1861 YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT
Sbjct: 1861 YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score = 3830 bits (9932), Expect = 0.0
 Identities = 1898/1907 (99%), Positives = 1898/1907 (99%), Gaps = 9/1907 (0%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
            NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS
Sbjct: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240

Query: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
            QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
Sbjct: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300

Query: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
            ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360

Query: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
            GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
            QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP
Sbjct: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480

Query: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
            GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI
Sbjct: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540

Query: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
            IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR
Sbjct: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600

Query: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
            TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD
Sbjct: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660

Query: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
            GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL
Sbjct: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720

Query: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780
            NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ         
Sbjct: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ--------- 771

Query: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 840
            ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW
Sbjct: 772  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 831

Query: 841  HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 900
            HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL
Sbjct: 832  HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 891

Query: 901  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS 960
            GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS
Sbjct: 892  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS 951

Query: 961  QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1020
            QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV
Sbjct: 952  QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1011

Query: 1021 AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR 1080
            AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR
Sbjct: 1012 AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR 1071

Query: 1081 GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID 1140
            GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID
Sbjct: 1072 GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID 1131

Query: 1141 RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL 1200
            RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL
Sbjct: 1132 RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL 1191

Query: 1201 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1260
            GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE
Sbjct: 1192 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1251

Query: 1261 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1320
            MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN
Sbjct: 1252 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1311

Query: 1321 YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR 1380
            YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR
Sbjct: 1312 YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR 1371

Query: 1381 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE 1440
            YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE
Sbjct: 1372 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE 1431

Query: 1441 QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS 1500
            QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS
Sbjct: 1432 QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS 1491

Query: 1501 SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560
            SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV
Sbjct: 1492 SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1551

Query: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL 1620
            IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL
Sbjct: 1552 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL 1611

Query: 1621 YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR 1680
            YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR
Sbjct: 1612 YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR 1671

Query: 1681 VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK 1740
            VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK
Sbjct: 1672 VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK 1731

Query: 1741 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1800
            LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF
Sbjct: 1732 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1791

Query: 1801 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR 1860
            TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR
Sbjct: 1792 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR 1851

Query: 1861 YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT
Sbjct: 1852 YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score = 2716 bits (7041), Expect = 0.0
 Identities = 1334/1897 (70%), Positives = 1567/1897 (82%), Gaps = 13/1897 (0%)

Query: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESS 197
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSGALQIE S
Sbjct: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQS 188

Query: 198  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVG 257
            EESDQGKYECVATNSAGTRYSAPANLYVRVRRV PRFSIPP++ E+MPGGSVN+TCVAVG
Sbjct: 189  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVG 248

Query: 258  APMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317
            +PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+IEA AQ+TVKA
Sbjct: 249  SPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKA 308

Query: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377
            LPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++E+DGVATTRYS+ 
Sbjct: 309  LPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVA 368

Query: 378  GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
            GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARMLS++T+LVQW+ P
Sbjct: 369  GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 428

Query: 438  EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
            EEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TYS++VLAFT++GDG
Sbjct: 429  EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 488

Query: 498  PPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQH 557
            P S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YELVY   E  ++Q 
Sbjct: 489  PLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQ- 547

Query: 558  KVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS 617
            ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS PSAPPQ + C S
Sbjct: 548  RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607

Query: 618  MGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKW 677
              ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  + + + L  LEKW
Sbjct: 608  PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667

Query: 678  TEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQ 737
            TEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+V V W+ PVP+KQ
Sbjct: 668  TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727

Query: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTV 797
            HGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQW  +++ +++  ISGL PET+YS+TV
Sbjct: 728  HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787

Query: 798  AAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQY 857
             AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP +  G L GYRL++
Sbjct: 788  TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 847

Query: 858  CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSG 917
             R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE  KEI  PE++P+G
Sbjct: 848  GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG 907

Query: 918  FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ---QELQNITTDTRFT 974
            FPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN      E   +  DT  T
Sbjct: 908  FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 967

Query: 975  LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEV 1034
            LTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V A MKTSVLLSWE+
Sbjct: 968  LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEI 1027

Query: 1035 PDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVS 1092
            P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL NRG+SAGGLQH V+
Sbjct: 1028 PENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1087

Query: 1093 IRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWS 1152
             +TAPD+L  KP        DG   + +P V     ++ +YI++VP+ +  G  + P W 
Sbjct: 1088 AKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP-WE 1146

Query: 1153 TPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNR 1212
            +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FTLGD K+Y GF N+
Sbjct: 1147 SPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNK 1204

Query: 1213 PLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QEEPEMLWVTGPVLA 1270
             L     Y  FVLA + E  + K YA+SPYSD +V      Q    EE  ++WV GPVLA
Sbjct: 1205 QLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 1263

Query: 1271 VILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHP 1330
            V+ II IVIAILL+KRKR  S S K       K+    H +DPVE+RRLN+QTPGM  HP
Sbjct: 1264 VVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQTPGMASHP 1322

Query: 1331 PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHS 1390
            PIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHS
Sbjct: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHS 1382

Query: 1391 RVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT 1450
            RV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM+WEQR+ATVVMMT
Sbjct: 1383 RVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1442

Query: 1451 RLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQ 1510
            +LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K+GSSEKRE+RQFQ
Sbjct: 1443 KLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQ 1502

Query: 1511 FMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH 1570
            F AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGCFIVIDAMLER+KH
Sbjct: 1503 FTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH 1562

Query: 1571 EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQV 1630
            EKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPARNLYA+IQKL Q+
Sbjct: 1563 EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI 1622

Query: 1631 PPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVE 1690
              GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVE
Sbjct: 1623 ETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE 1682

Query: 1691 GSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH 1750
            GSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VMLTKLREMGREKCH
Sbjct: 1683 GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH 1742

Query: 1751 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK 1810
            QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK
Sbjct: 1743 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK 1802

Query: 1811 TGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT 1870
            +GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQT
Sbjct: 1803 SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQT 1862

Query: 1871 VKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            VK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1863 VKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score = 2703 bits (7006), Expect = 0.0
 Identities = 1334/1910 (69%), Positives = 1567/1910 (82%), Gaps = 26/1910 (1%)

Query: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188

Query: 190  -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
             GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 189  RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 245  PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
            PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 249  PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308

Query: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
            G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 309  GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 365  EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
            E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 425  LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
            LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 429  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488

Query: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
            S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 489  SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548

Query: 545  LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
            LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 549  LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 605  TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
             PSAPPQ + C S  ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  
Sbjct: 608  KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667

Query: 665  EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
            + + + L  LEKWTEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 668  DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727

Query: 725  VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
            V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQW  +++ +++  I
Sbjct: 728  VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMII 787

Query: 785  SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 844
            SGL PET+YS+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP 
Sbjct: 788  SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV 847

Query: 845  ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 904
            +  G L GYRL++ R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE 
Sbjct: 848  DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM 907

Query: 905  EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--- 961
             KEI  PE++P+GFPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN     
Sbjct: 908  VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 967

Query: 962  QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1021
             E   +  DT  TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V 
Sbjct: 968  MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVK 1027

Query: 1022 AAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMN 1079
            A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL N
Sbjct: 1028 AVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN 1087

Query: 1080 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1139
            RG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++ +YI++VP+
Sbjct: 1088 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPL 1147

Query: 1140 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFT 1199
             +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FT
Sbjct: 1148 KKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFT 1204

Query: 1200 LGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QE 1257
            LGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V      Q    E
Sbjct: 1205 LGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDE 1263

Query: 1258 EPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMR 1317
            E  ++WV GPVLAV+ II IVIAILL+KRKR  S S K       K+    H +DPVE+R
Sbjct: 1264 EEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELR 1322

Query: 1318 RLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKP 1377
            RLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKP
Sbjct: 1323 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKP 1382

Query: 1378 KNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM 1437
            KNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM
Sbjct: 1383 KNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRM 1442

Query: 1438 VWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK 1497
            +WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K
Sbjct: 1443 IWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK 1502

Query: 1498 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGC 1557
            +GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGC
Sbjct: 1503 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1562

Query: 1558 FIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA 1617
            FIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPA
Sbjct: 1563 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1622

Query: 1618 RNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1677
            RNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1623 RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1682

Query: 1678 LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM 1737
             TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VM
Sbjct: 1683 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1742

Query: 1738 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQ 1797
            LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQ
Sbjct: 1743 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1802

Query: 1798 FQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE 1857
            FQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLE
Sbjct: 1803 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1862

Query: 1858 RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            RMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1863 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score = 2689 bits (6971), Expect = 0.0
 Identities = 1333/1910 (69%), Positives = 1561/1910 (81%), Gaps = 35/1910 (1%)

Query: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188

Query: 190  -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
             GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 189  RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 245  PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
            PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 249  PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308

Query: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
            G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 309  GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 365  EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
            E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 425  LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
            LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 429  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488

Query: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
            S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 489  SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548

Query: 545  LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
            LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 549  LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 605  TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
             PSAPPQ + C S  ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  
Sbjct: 608  KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667

Query: 665  EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
            + + + L  LEKWTEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 668  DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727

Query: 725  VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
            V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ         +  I
Sbjct: 728  VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ---------DMII 778

Query: 785  SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 844
            SGL PET+YS+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP 
Sbjct: 779  SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV 838

Query: 845  ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 904
            +  G L GYRL++ R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE 
Sbjct: 839  DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM 898

Query: 905  EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--- 961
             KEI  PE++P+GFPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN     
Sbjct: 899  VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 958

Query: 962  QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1021
             E   +  DT  TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V 
Sbjct: 959  MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVK 1018

Query: 1022 AAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMN 1079
            A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL N
Sbjct: 1019 AVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN 1078

Query: 1080 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1139
            RG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++ +YI++VP+
Sbjct: 1079 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPL 1138

Query: 1140 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFT 1199
             +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FT
Sbjct: 1139 KKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFT 1195

Query: 1200 LGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QE 1257
            LGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V      Q    E
Sbjct: 1196 LGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDE 1254

Query: 1258 EPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMR 1317
            E  ++WV GPVLAV+ II IVIAILL+KRKR  S S K       K+    H +DPVE+R
Sbjct: 1255 EEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELR 1313

Query: 1318 RLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKP 1377
            RLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKP
Sbjct: 1314 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKP 1373

Query: 1378 KNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM 1437
            KNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM
Sbjct: 1374 KNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRM 1433

Query: 1438 VWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK 1497
            +WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K
Sbjct: 1434 IWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK 1493

Query: 1498 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGC 1557
            +GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGC
Sbjct: 1494 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1553

Query: 1558 FIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA 1617
            FIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPA
Sbjct: 1554 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1613

Query: 1618 RNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1677
            RNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1614 RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1673

Query: 1678 LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM 1737
             TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VM
Sbjct: 1674 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1733

Query: 1738 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQ 1797
            LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQ
Sbjct: 1734 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1793

Query: 1798 FQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE 1857
            FQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLE
Sbjct: 1794 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1853

Query: 1858 RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            RMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1854 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 2564 bits (6646), Expect = 0.0
 Identities = 1301/1927 (67%), Positives = 1500/1927 (77%), Gaps = 37/1927 (1%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
            NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181  NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240

Query: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
             E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANYTCVA
Sbjct: 241  HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300

Query: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
            +SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++   +
Sbjct: 301  MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360

Query: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
            GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S PR V
Sbjct: 361  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420

Query: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
            QARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVGSLL 
Sbjct: 421  QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
              TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P QE I
Sbjct: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540

Query: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
            I YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP +  R
Sbjct: 541  IKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599

Query: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
            T QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y  +  ED     V+
Sbjct: 600  TLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVN 659

Query: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
            GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDVPS PPRKVE E L
Sbjct: 660  GIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEAL 719

Query: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780
            N+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVMLA+AQ         
Sbjct: 720  NATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ--------- 770

Query: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 840
            E  I+ L PET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ +  T   + L +W
Sbjct: 771  EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARW 830

Query: 841  HPPK-ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAG 899
             PP      ++LGYRLQ+ R D     T++F   +  +T +G+HKG TY+FRLAA++R G
Sbjct: 831  EPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGG 890

Query: 900  LGEEFEKEIRTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERNGRIISYTVVFRDI 958
            LGEE  + +  PED P G PQ L   G  +  T  L W PPV AERNG I+ YTV  R+ 
Sbjct: 891  LGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREA 950

Query: 959  NS-----QQELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPV 1010
             +     + EL        +   TL GLKPDT YD++VRA T +G GP SP ++ RT   
Sbjct: 951  GALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLR 1010

Query: 1011 EQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPN 1070
            +QV  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+P+
Sbjct: 1011 DQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPH 1070

Query: 1071 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1130
            T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  V+
Sbjct: 1071 TFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQ 1130

Query: 1131 WFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA 1189
             ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+AA
Sbjct: 1131 SYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA 1189

Query: 1190 QLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQ 1249
            +  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   + 
Sbjct: 1190 RFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLD 1247

Query: 1250 VTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLL 1307
                Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      LL
Sbjct: 1248 NPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLL 1303

Query: 1308 A-------HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID 1360
                    H  DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYESID
Sbjct: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 1363

Query: 1361 PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAY 1420
            PGQQFTWE+SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QNAY
Sbjct: 1364 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1423

Query: 1421 IATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLL 1480
            IATQGPLPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLL
Sbjct: 1424 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1483

Query: 1481 DTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD 1540
            DT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP D
Sbjct: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543

Query: 1541 AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI 1600
            AGP+VVHCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FI
Sbjct: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603

Query: 1601 HEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISAN 1660
            HEALLEA  CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISAN
Sbjct: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1663

Query: 1661 LPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAEST 1720
            LPCNKFKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+T
Sbjct: 1664 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1723

Query: 1721 EDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1780
            EDFWRMLWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR
Sbjct: 1724 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1783

Query: 1781 EFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCS 1840
            EFKVTDARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCS
Sbjct: 1784 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1843

Query: 1841 AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG 1900
            AGVGRTGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLG
Sbjct: 1844 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1903

Query: 1901 SFDHYAT 1907
            SFDHYAT
Sbjct: 1904 SFDHYAT 1910


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 2555 bits (6621), Expect = 0.0
 Identities = 1302/1956 (66%), Positives = 1505/1956 (76%), Gaps = 57/1956 (2%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRS---------GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----V 227
            NGRIKQLRS         GALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR    V
Sbjct: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240

Query: 228  RRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLEL 287
            RRVAPRFSI P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL
Sbjct: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300

Query: 288  SNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPV 347
            ++V  SANYTCVA+SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV
Sbjct: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360

Query: 348  TYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407
            +YY I+Y++   +GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  R
Sbjct: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420

Query: 408  TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT 467
            TGEQAP+S PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN 
Sbjct: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480

Query: 468  DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527
            D  LLTTVGSLL   TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T 
Sbjct: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540

Query: 528  IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSD 587
            I LSW  P QE II YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS 
Sbjct: 541  ITLSWSPPRQESIIKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 599

Query: 588  MGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYE 647
             G+G FTP +  RT QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y 
Sbjct: 600  QGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYR 659

Query: 648  AVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDV 707
             +  ED     V+GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDV
Sbjct: 660  PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDV 719

Query: 708  PSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVML 767
            PS PPRKVE E LN+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVML
Sbjct: 720  PSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVML 779

Query: 768  AEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM 827
            A+AQW  +++ +YE  I+ L PET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ 
Sbjct: 780  ADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS 839

Query: 828  ISTTAMNTALLQWHPPK-ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGT 886
            +  T   + L +W PP      ++LGYRLQ+ R D     T++F   +  +T +G+HKG 
Sbjct: 840  VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGA 899

Query: 887  TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERN 945
            TY+FRLAA++R GLGEE  + +  PED P G PQ L   G  +  T  L W PPV AERN
Sbjct: 900  TYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959

Query: 946  GRIISYTVVFRDINS-----QQELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
            G I+ YTV  R+  +     + EL        +   TL GLKPDT YD++VRA T +G G
Sbjct: 960  GAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG 1019

Query: 998  PLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDG 1057
            P SP ++ RT   +QV  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG
Sbjct: 1020 PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDG 1079

Query: 1058 HSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFD 1117
             + +KLI  L+P+T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   
Sbjct: 1080 RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 1139

Query: 1118 LSMPHVQDPSLVRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRR 1176
            + +P  Q P  V+ ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R 
Sbjct: 1140 VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRH 1198

Query: 1177 RRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKR 1236
             RQ E  +PY+AA+  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  
Sbjct: 1199 SRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPT 1256

Query: 1237 YASSPYSDEIVVQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSS 1294
            +A+SP+SD   +     Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P S
Sbjct: 1257 FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDS 1312

Query: 1295 KDEQSIGLKDSLLA-------HSSDPVEMRRLNYQTP----------------GMRDHPP 1331
            K + S      LL        H  DPVEMRR+N+QTP                 M  HPP
Sbjct: 1313 KRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPP 1372

Query: 1332 IPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSR 1391
            IPI D+A++ ERLKAND LK SQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSR
Sbjct: 1373 IPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1432

Query: 1392 VILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTR 1451
            VIL  I+G+ GSDYINANY+DGYR QNAYIATQGPLPET GDFWRMVWEQR+AT+VMMTR
Sbjct: 1433 VILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492

Query: 1452 LEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1511
            LEEKSR+KCDQYWP RGTET G IQVTLLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF
Sbjct: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552

Query: 1512 MAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE 1571
             AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VVHCSAGVGRTGCFIVIDAMLER+K E
Sbjct: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE 1612

Query: 1572 KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVP 1631
            KTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLEA  CG+TEVPAR+LYA+IQKL QV 
Sbjct: 1613 KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVE 1672

Query: 1632 PGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG 1691
            PGE VT MELEFK LA+SKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEG
Sbjct: 1673 PGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1732

Query: 1692 SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ 1751
            SDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQ
Sbjct: 1733 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ 1792

Query: 1752 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKT 1811
            YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+
Sbjct: 1793 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1852

Query: 1812 GEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTV 1871
            GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQTV
Sbjct: 1853 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTV 1912

Query: 1872 KTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            K LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYAT
Sbjct: 1913 KMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score = 1449 bits (3751), Expect = 0.0
 Identities = 750/1136 (66%), Positives = 873/1136 (76%), Gaps = 24/1136 (2%)

Query: 783  TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 840
            +++GL+P + Y   V A    G G  S+P +  T+   P      +    ++  T L+QW
Sbjct: 379  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 841  HPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAKNRA 898
              P+E  G++ GYR+ Y        N        D Q  T+  L    TY  ++ A    
Sbjct: 439  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498

Query: 899  GLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
            G G    + ++ T   +P G P N      + ++  L+W PP    R+  I +Y +V++D
Sbjct: 499  GDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKD 553

Query: 958  INSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA 1015
                +E Q IT +  T + L GLKP++ Y  ++ A + +G G  +  I +RTM  + +FA
Sbjct: 554  GEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QSMFA 610

Query: 1016 KNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEY 1073
            KNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   Y
Sbjct: 611  KNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSY 670

Query: 1074 SFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFY 1133
            SFVL NRG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++ +Y
Sbjct: 671  SFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYY 730

Query: 1134 IVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDV 1193
            I++VP+ +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DV
Sbjct: 731  IIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDV 787

Query: 1194 LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPA 1253
            LP  FTLGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V      
Sbjct: 788  LPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDP 846

Query: 1254 QQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSS 1311
            Q    EE  ++WV GPVLAV+ II IVIAILL+KRKR  S S K       K+    H +
Sbjct: 847  QPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPT 905

Query: 1312 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSN 1371
            DPVE+RRLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SN
Sbjct: 906  DPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSN 965

Query: 1372 LEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETM 1431
            LEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET 
Sbjct: 966  LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF 1025

Query: 1432 GDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVR 1491
            GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VR
Sbjct: 1026 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVR 1085

Query: 1492 TFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAG 1551
            TFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAG
Sbjct: 1086 TFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAG 1145

Query: 1552 VGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG 1611
            VGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG
Sbjct: 1146 VGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCG 1205

Query: 1612 HTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLV 1671
            +TEVPARNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLV
Sbjct: 1206 NTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLV 1265

Query: 1672 NIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHN 1731
            NIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHN
Sbjct: 1266 NIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN 1325

Query: 1732 STIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1791
            STI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ
Sbjct: 1326 STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1385

Query: 1792 SRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFIT 1851
            SRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFIT
Sbjct: 1386 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1445

Query: 1852 LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            LSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1446 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501



 Score =  804 bits (2077), Expect = 0.0
 Identities = 404/626 (64%), Positives = 496/626 (79%), Gaps = 17/626 (2%)

Query: 18  LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
           L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9   LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78  FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
           FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69  FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
           DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188

Query: 190 -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
            GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 189 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 245 PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
           PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 249 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308

Query: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
           G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
           E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 425 LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
           LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488

Query: 485 SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
           S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 489 SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548

Query: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
           LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 549 LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 605 TPSAPPQKVMCVSMGSTTVRVSWVPP 630
             +   +     ++  T+V +SW  P
Sbjct: 608 MFA---KNFHVKAVMKTSVLLSWEIP 630



 Score =  144 bits (364), Expect = 6e-34
 Identities = 122/435 (28%), Positives = 193/435 (44%), Gaps = 45/435 (10%)

Query: 580  FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
            +   A S +GV      I   T ++ P  P   V+  S  +T++ ++W     DS N   
Sbjct: 300  YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 350

Query: 640  TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
              Y +        +     +DG++   + + + GL  +++Y   V A  ++G GP S PV
Sbjct: 351  VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408

Query: 700  LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
            L +T E  PS  PR V+   L+ST + V WK   P + +GQI+GY+V Y           
Sbjct: 409  LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYT---------- 456

Query: 760  PIIQDVMLAEAQWRPEESEDYE-TTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTG 818
                D       W      D + TTI  L P+ TYSV V A+T+ GDG  S    V T  
Sbjct: 457  ---MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 513

Query: 819  AVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHF 877
             VPG+P    +     T+ LL W PP+     +  Y L Y   +      I   +    +
Sbjct: 514  GVPGQPLNFKAEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSY 570

Query: 878  TVTGLHKGTTYIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 936
             + GL   + Y FRLAA++  GLG    E   RT   + S F +N HV  +  ++  L+W
Sbjct: 571  RLQGLKPNSLYYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSW 627

Query: 937  DPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG- 995
            + P   E     + + +++ D    +E+    T     +  LKP+ +Y   +   T++G 
Sbjct: 628  EIP---ENYNSAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGN 679

Query: 996  -SGPLSPSIQSRTMP 1009
             +G L   + ++T P
Sbjct: 680  SAGGLQHRVTAKTAP 694


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score = 1444 bits (3737), Expect = 0.0
 Identities = 746/1139 (65%), Positives = 872/1139 (76%), Gaps = 26/1139 (2%)

Query: 783  TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 840
            +++GL+P + Y   V A    G G  S+P +  T+   P      +    ++  T L+QW
Sbjct: 376  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435

Query: 841  HPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAKNRA 898
              P+E  G++ GYR+ Y        N        D Q  T+  L    TY  ++ A    
Sbjct: 436  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 495

Query: 899  GLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
            G G    + ++ T   +P G P N      + ++  L+W PP    R+  I +Y +V++D
Sbjct: 496  GDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKD 550

Query: 958  INSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA 1015
                +E Q IT +  T + L GLKP++ Y  ++ A + +G G  +  I +RTM  + +FA
Sbjct: 551  GEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QSMFA 607

Query: 1016 KNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEY 1073
            KNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   Y
Sbjct: 608  KNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSY 667

Query: 1074 SFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFY 1133
            SFVL NRG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++ +Y
Sbjct: 668  SFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYY 727

Query: 1134 IVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDV 1193
            I++VP+ +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DV
Sbjct: 728  IIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDV 784

Query: 1194 LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPA 1253
            LP  FTLGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V      
Sbjct: 785  LPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDP 843

Query: 1254 QQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGL---KDSLLA 1308
            Q    EE  ++WV GPVLAV+ II IVIAILL+K K     +  D +   +   K+    
Sbjct: 844  QPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSH 903

Query: 1309 HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWE 1368
            H +DPVE+RRLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE
Sbjct: 904  HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 963

Query: 1369 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP 1428
            +SNLEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LP
Sbjct: 964  HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1023

Query: 1429 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY 1488
            ET GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY
Sbjct: 1024 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1083

Query: 1489 TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHC 1548
             VRTFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHC
Sbjct: 1084 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1143

Query: 1549 SAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA 1608
            SAGVGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA 
Sbjct: 1144 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203

Query: 1609 TCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKN 1668
            TCG+TEVPARNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKN
Sbjct: 1204 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1263

Query: 1669 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1728
            RLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLW
Sbjct: 1264 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1323

Query: 1729 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1788
            EHNSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR
Sbjct: 1324 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1383

Query: 1789 DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGV 1848
            DGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGV
Sbjct: 1384 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1443

Query: 1849 FITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
            FITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1444 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502



 Score =  805 bits (2080), Expect = 0.0
 Identities = 404/623 (64%), Positives = 496/623 (79%), Gaps = 14/623 (2%)

Query: 18  LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
           L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9   LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78  FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
           FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69  FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSG------A 191
           DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSG      A
Sbjct: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGA 188

Query: 192 LQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVMPGG 247
           LQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+MPGG
Sbjct: 189 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248

Query: 248 SVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMI 307
           SVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+I
Sbjct: 249 SVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVI 308

Query: 308 EATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVD 367
           EA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++E+D
Sbjct: 309 EAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEID 368

Query: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSA 427
           GVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARMLS+
Sbjct: 369 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 428

Query: 428 STMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLR 487
           +T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TYS++
Sbjct: 429 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVK 488

Query: 488 VLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVY 547
           VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YELVY
Sbjct: 489 VLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVY 548

Query: 548 WAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPS 607
              E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS  +
Sbjct: 549 KDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA 607

Query: 608 APPQKVMCVSMGSTTVRVSWVPP 630
              +     ++  T+V +SW  P
Sbjct: 608 ---KNFHVKAVMKTSVLLSWEIP 627



 Score =  144 bits (364), Expect = 6e-34
 Identities = 122/435 (28%), Positives = 193/435 (44%), Gaps = 45/435 (10%)

Query: 580  FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
            +   A S +GV      I   T ++ P  P   V+  S  +T++ ++W     DS N   
Sbjct: 297  YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 347

Query: 640  TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
              Y +        +     +DG++   + + + GL  +++Y   V A  ++G GP S PV
Sbjct: 348  VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405

Query: 700  LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
            L +T E  PS  PR V+   L+ST + V WK   P + +GQI+GY+V Y           
Sbjct: 406  LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYT---------- 453

Query: 760  PIIQDVMLAEAQWRPEESEDYE-TTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTG 818
                D       W      D + TTI  L P+ TYSV V A+T+ GDG  S    V T  
Sbjct: 454  ---MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 510

Query: 819  AVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHF 877
             VPG+P    +     T+ LL W PP+     +  Y L Y   +      I   +    +
Sbjct: 511  GVPGQPLNFKAEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSY 567

Query: 878  TVTGLHKGTTYIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 936
             + GL   + Y FRLAA++  GLG    E   RT   + S F +N HV  +  ++  L+W
Sbjct: 568  RLQGLKPNSLYYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSW 624

Query: 937  DPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG- 995
            + P   E     + + +++ D    +E+    T     +  LKP+ +Y   +   T++G 
Sbjct: 625  EIP---ENYNSAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGN 676

Query: 996  -SGPLSPSIQSRTMP 1009
             +G L   + ++T P
Sbjct: 677  SAGGLQHRVTAKTAP 691


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 1407 bits (3642), Expect = 0.0
 Identities = 736/1149 (64%), Positives = 861/1149 (74%), Gaps = 33/1149 (2%)

Query: 778  EDYETT---ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN 834
            ED  TT   I GL+P + Y + V+A  + G G  S+  +  T    P      +    ++
Sbjct: 371  EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLS 430

Query: 835  --TALLQWHPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIF 890
              T ++QW  P E  G + GYR+ Y    E    N      DD   T  G L +  TY  
Sbjct: 431  ATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTV 490

Query: 891  RLAAKNRAGLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949
            R+ A    G G   +  +++T + +P G P NL     + ++  L+W PP    R   II
Sbjct: 491  RVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESII 545

Query: 950  SYTVVFRDINSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
             Y ++FR+ +  +E+ +     T + +  LKP+T Y  ++ A + +G G  +P ++ RT+
Sbjct: 546  KYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL 605

Query: 1009 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQ 1068
              + +  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+
Sbjct: 606  --QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLK 663

Query: 1069 PNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
            P+T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  
Sbjct: 664  PHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVP 723

Query: 1129 VRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYV 1187
            V+ ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+
Sbjct: 724  VQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYI 782

Query: 1188 AAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIV 1247
            AA+  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   
Sbjct: 783  AARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQ 840

Query: 1248 VQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDS 1305
            +     Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      
Sbjct: 841  LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKC 896

Query: 1306 LLA-------HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYES 1358
            LL        H  DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYES
Sbjct: 897  LLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYES 956

Query: 1359 IDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQN 1418
            IDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QN
Sbjct: 957  IDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1016

Query: 1419 AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVT 1478
            AYIATQGPLPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVT
Sbjct: 1017 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1076

Query: 1479 LLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP 1538
            LLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP
Sbjct: 1077 LLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP 1136

Query: 1539 LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYV 1598
             DAGP+VVHCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY 
Sbjct: 1137 PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS 1196

Query: 1599 FIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFIS 1658
            FIHEALLEA  CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFIS
Sbjct: 1197 FIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS 1256

Query: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
            ANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316

Query: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1778
            +TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1376

Query: 1779 LREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1838
            LREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VH
Sbjct: 1377 LREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH 1436

Query: 1839 CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1898
            CSAGVGRTGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEY
Sbjct: 1437 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1496

Query: 1899 LGSFDHYAT 1907
            LGSFDHYAT
Sbjct: 1497 LGSFDHYAT 1505



 Score =  838 bits (2165), Expect = 0.0
 Identities = 440/715 (61%), Positives = 528/715 (73%), Gaps = 27/715 (3%)

Query: 1   MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
           MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
           KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
           KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSI 236
           NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR    VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240

Query: 237 PPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANY 296
            P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANY
Sbjct: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300

Query: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
           TCVA+SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360

Query: 357 AGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP 416
              +GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S 
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420

Query: 417 PRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVG 476
           PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVG
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480

Query: 477 SLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP 536
           SLL   TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P 
Sbjct: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540

Query: 537 QERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596
           QE II YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP 
Sbjct: 541 QESIIKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599

Query: 597 IEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR 656
           +  RT Q   S  P+      +  T+V +SW  P  D+ N   T Y + Y  +  +  GR
Sbjct: 600 VRQRTLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGR 653

Query: 657 HVVDGIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
                I+  + H+ ++ V         GL++    WT + + +     V P P++
Sbjct: 654 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 707



 Score =  138 bits (347), Expect = 6e-32
 Identities = 123/431 (28%), Positives = 190/431 (44%), Gaps = 47/431 (10%)

Query: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
           L D+K    Y     A S +GV      I  ++    P  P    M     +T++ ++W 
Sbjct: 291 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 343

Query: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
               DS N     Y V       +D    + + I+   + + + GL   +EY +WV A  
Sbjct: 344 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 397

Query: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
            +G GP S  V+ RT E  P+  PR V+   L++T + V W+ PV  + +G IRGY+V Y
Sbjct: 398 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 454

Query: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESED-YETTISGLTPETTYSVTVAAYTTKGDGA 807
             +E   P G             W+    +D   TT+  L  + TY+V V A+T+ GDG 
Sbjct: 455 YTMEPEHPVG------------NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 502

Query: 808 RSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPN 866
            S P  V T   VPG+P  + +     T++ L W PP++    ++ Y L +   D  R  
Sbjct: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREV 560

Query: 867 TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG 926
              F      + V  L   T Y FRLAA++  GLG  F   +R    L S  P+N  V  
Sbjct: 561 GRTFDPTTS-YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKM 617

Query: 927 LTTSTTELAWD-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
           +  ++  L+W+ P          I Y  +  D++ +         T+  +T LKP T Y+
Sbjct: 618 IMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYN 669

Query: 986 IKVRAWTSKGS 996
             +   T++GS
Sbjct: 670 FVL---TNRGS 677



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)

Query: 910  TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 966
            T + LP   P    VT  T ++  + WD       N   +SY V+     SQ    +++ 
Sbjct: 318  TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 371

Query: 967  ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1025
              T TR+++ GL P++ Y+I V A  S G GP S S+ +RT       A +N +      
Sbjct: 372  DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 431

Query: 1026 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1075
            T++++ WE P            Y +  P   + N Q   VD   +  + + L+  T    
Sbjct: 432  TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 491

Query: 1076 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1105
            VL       G L   + ++T    +P +P+
Sbjct: 492  VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 520


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 1407 bits (3642), Expect = 0.0
 Identities = 736/1149 (64%), Positives = 861/1149 (74%), Gaps = 33/1149 (2%)

Query: 778  EDYETT---ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN 834
            ED  TT   I GL+P + Y + V+A  + G G  S+  +  T    P      +    ++
Sbjct: 367  EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLS 426

Query: 835  --TALLQWHPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIF 890
              T ++QW  P E  G + GYR+ Y    E    N      DD   T  G L +  TY  
Sbjct: 427  ATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTV 486

Query: 891  RLAAKNRAGLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949
            R+ A    G G   +  +++T + +P G P NL     + ++  L+W PP    R   II
Sbjct: 487  RVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESII 541

Query: 950  SYTVVFRDINSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
             Y ++FR+ +  +E+ +     T + +  LKP+T Y  ++ A + +G G  +P ++ RT+
Sbjct: 542  KYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL 601

Query: 1009 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQ 1068
              + +  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+
Sbjct: 602  --QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLK 659

Query: 1069 PNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
            P+T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  
Sbjct: 660  PHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVP 719

Query: 1129 VRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYV 1187
            V+ ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+
Sbjct: 720  VQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYI 778

Query: 1188 AAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIV 1247
            AA+  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   
Sbjct: 779  AARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQ 836

Query: 1248 VQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDS 1305
            +     Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      
Sbjct: 837  LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKC 892

Query: 1306 LLA-------HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYES 1358
            LL        H  DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYES
Sbjct: 893  LLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYES 952

Query: 1359 IDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQN 1418
            IDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QN
Sbjct: 953  IDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1012

Query: 1419 AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVT 1478
            AYIATQGPLPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVT
Sbjct: 1013 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1072

Query: 1479 LLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP 1538
            LLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP
Sbjct: 1073 LLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP 1132

Query: 1539 LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYV 1598
             DAGP+VVHCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY 
Sbjct: 1133 PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS 1192

Query: 1599 FIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFIS 1658
            FIHEALLEA  CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFIS
Sbjct: 1193 FIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS 1252

Query: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
            ANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312

Query: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1778
            +TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1372

Query: 1779 LREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1838
            LREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VH
Sbjct: 1373 LREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH 1432

Query: 1839 CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1898
            CSAGVGRTGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEY
Sbjct: 1433 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1492

Query: 1899 LGSFDHYAT 1907
            LGSFDHYAT
Sbjct: 1493 LGSFDHYAT 1501



 Score =  844 bits (2180), Expect = 0.0
 Identities = 440/711 (61%), Positives = 528/711 (74%), Gaps = 23/711 (3%)

Query: 1   MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
           MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
           KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
           KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
           NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240

Query: 241 QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
            E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANYTCVA
Sbjct: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300

Query: 301 ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
           +SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++   +
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360

Query: 361 GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
           GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S PR V
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420

Query: 421 QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
           QARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVGSLL 
Sbjct: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 481 GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
             TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P QE I
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540

Query: 541 IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
           I YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP +  R
Sbjct: 541 IKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599

Query: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
           T Q   S  P+      +  T+V +SW  P  D+ N   T Y + Y  +  +  GR    
Sbjct: 600 TLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGRTTKK 653

Query: 661 GIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
            I+  + H+ ++ V         GL++    WT + + +     V P P++
Sbjct: 654 LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 703



 Score =  138 bits (347), Expect = 6e-32
 Identities = 123/431 (28%), Positives = 190/431 (44%), Gaps = 47/431 (10%)

Query: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
           L D+K    Y     A S +GV      I  ++    P  P    M     +T++ ++W 
Sbjct: 287 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 339

Query: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
               DS N     Y V       +D    + + I+   + + + GL   +EY +WV A  
Sbjct: 340 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 393

Query: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
            +G GP S  V+ RT E  P+  PR V+   L++T + V W+ PV  + +G IRGY+V Y
Sbjct: 394 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 450

Query: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESED-YETTISGLTPETTYSVTVAAYTTKGDGA 807
             +E   P G             W+    +D   TT+  L  + TY+V V A+T+ GDG 
Sbjct: 451 YTMEPEHPVG------------NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498

Query: 808 RSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPN 866
            S P  V T   VPG+P  + +     T++ L W PP++    ++ Y L +   D  R  
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREV 556

Query: 867 TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG 926
              F      + V  L   T Y FRLAA++  GLG  F   +R    L S  P+N  V  
Sbjct: 557 GRTFDPTTS-YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKM 613

Query: 927 LTTSTTELAWD-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
           +  ++  L+W+ P          I Y  +  D++ +         T+  +T LKP T Y+
Sbjct: 614 IMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYN 665

Query: 986 IKVRAWTSKGS 996
             +   T++GS
Sbjct: 666 FVL---TNRGS 673



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)

Query: 910  TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 966
            T + LP   P    VT  T ++  + WD       N   +SY V+     SQ    +++ 
Sbjct: 314  TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 367

Query: 967  ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1025
              T TR+++ GL P++ Y+I V A  S G GP S S+ +RT       A +N +      
Sbjct: 368  DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 427

Query: 1026 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1075
            T++++ WE P            Y +  P   + N Q   VD   +  + + L+  T    
Sbjct: 428  TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 487

Query: 1076 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1105
            VL       G L   + ++T    +P +P+
Sbjct: 488  VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 516


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 1269 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 153  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 207

Query: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1386
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 208  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 267

Query: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 268  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 327

Query: 1447 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1505
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 328  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387

Query: 1506 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1562
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 388  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 447

Query: 1563 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1622
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 448  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 507

Query: 1623 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1682
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 508  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1683 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1742
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1743 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1802
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 687

Query: 1803 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1862
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 688  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 746

Query: 1863 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1906
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 747  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 1269 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 162  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 216

Query: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1386
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 217  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 276

Query: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 277  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 336

Query: 1447 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1505
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 337  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 396

Query: 1506 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1562
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 397  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 456

Query: 1563 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1622
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 457  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 516

Query: 1623 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1682
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 517  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 576

Query: 1683 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1742
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 577  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 636

Query: 1743 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1802
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 637  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 696

Query: 1803 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1862
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 697  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 755

Query: 1863 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1906
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 756  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 799


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 1269 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 153  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 207

Query: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1386
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 208  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 267

Query: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 268  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 327

Query: 1447 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1505
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 328  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387

Query: 1506 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1562
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 388  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 447

Query: 1563 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1622
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 448  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 507

Query: 1623 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1682
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 508  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1683 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1742
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1743 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1802
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 687

Query: 1803 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1862
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 688  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 746

Query: 1863 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1906
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 747  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  566 bits (1459), Expect = e-161
 Identities = 294/664 (44%), Positives = 418/664 (62%), Gaps = 14/664 (2%)

Query: 1252 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSS 1311
            P     +P + W+  P+L ++L++L+      F+++R    S+ D++   + + +L    
Sbjct: 39   PDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKK---MPNGIL-EEQ 94

Query: 1312 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENS 1370
            +   +  L+    G + + PIP+  L + I    A+D  +F +E+ S+  G  Q T+E +
Sbjct: 95   EQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELA 154

Query: 1371 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1430
            N E N+ KNRY N++  DHSRVIL+ +DG+P SDYINA+YIDGY+++N +IA QGP  ET
Sbjct: 155  NKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQET 214

Query: 1431 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1490
            + DFWRMVWEQ++AT+VM+T L+E+   KC QYWP +G  T G I+V + D V L  YT+
Sbjct: 215  VNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTI 274

Query: 1491 RTFALHKS---GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1547
            R F +      G    R + Q  F +WPD GVP  P  +L FL++VK  NP+ AGP+VVH
Sbjct: 275  RKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVH 334

Query: 1548 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1607
            CSAGVGRTG FIVIDAM+  M  E+ VD++  V+ +R+QR  MVQT+ QY FI++ALLE 
Sbjct: 335  CSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394

Query: 1608 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFK 1667
               G TE+   +L  H+Q +           +E EF+ L + +       + NLP N  K
Sbjct: 395  YLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKK 454

Query: 1668 NRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRML 1727
             R++ I+PY+  RV L   RG E +DYINASF+DGYRQ+  +IATQGPLA + EDFWRM+
Sbjct: 455  ARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMI 514

Query: 1728 WEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-- 1785
            WE  S  IVMLT+++E  ++KC+QYWP E S  +    ++   +       +R+F VT  
Sbjct: 515  WEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLN 574

Query: 1786 ---DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAG 1842
                 ++ Q R +RQF F  WPE G+P  G+G ID I  V K ++Q G + PITVHCSAG
Sbjct: 575  QPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAG 633

Query: 1843 VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF 1902
             GRTG FI LS +LER++ EG++D+FQ VK+LR QRP MVQT +QY+ CY+   +++  F
Sbjct: 634  AGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIF 693

Query: 1903 DHYA 1906
              YA
Sbjct: 694  SDYA 697


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  551 bits (1420), Expect = e-156
 Identities = 287/632 (45%), Positives = 402/632 (63%), Gaps = 14/632 (2%)

Query: 1284 FKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIER 1343
            F+++R    S+ D++   + + +L    +   +  L+    G + + PIP+  L + I  
Sbjct: 13   FRKQRKAVVSTSDKK---MPNGIL-EEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRI 68

Query: 1344 LKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG 1402
              A+D  +F +E+ S+  G  Q T+E +N E N+ KNRY N++  DHSRVIL+ +DG+P 
Sbjct: 69   RSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPC 128

Query: 1403 SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ 1462
            SDYINA+YIDGY+++N +IA QGP  ET+ DFWRMVWEQ++AT+VM+T L+E+   KC Q
Sbjct: 129  SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQ 188

Query: 1463 YWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS---GSSEKRELRQFQFMAWPDHGV 1519
            YWP +G  T G I+V + D V L  YT+R F +      G    R + Q  F +WPD GV
Sbjct: 189  YWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGV 248

Query: 1520 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1579
            P  P  +L FL++VK  NP+ AGP+VVHCSAGVGRTG FIVIDAM+  M  E+ VD++  
Sbjct: 249  PFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEF 308

Query: 1580 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1639
            V+ +R+QR  MVQT+ QY FI++ALLE    G TE+   +L  H+Q +           +
Sbjct: 309  VSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGL 368

Query: 1640 ELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1699
            E EF+ L + +       + NLP N  K R++ I+PY+  RV L   RG E +DYINASF
Sbjct: 369  EEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 428

Query: 1700 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1759
            +DGYRQ+  +IATQGPLA + EDFWRM+WE  S  IVMLT+++E  ++KC+QYWP E S 
Sbjct: 429  IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV 488

Query: 1760 RYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTIRQFQFTDWPEQGVPKTGEG 1814
             +    ++   +       +R+F VT       ++ Q R +RQF F  WPE G+P  G+G
Sbjct: 489  THGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKG 548

Query: 1815 FIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTL 1874
             ID I  V K ++Q G + PITVHCSAG GRTG FI LS +LER++ EG++D+FQ VK+L
Sbjct: 549  MIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607

Query: 1875 RTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1906
            R QRP MVQT +QY+ CY+   +++  F  YA
Sbjct: 608  RLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  510 bits (1313), Expect = e-144
 Identities = 351/1090 (32%), Positives = 542/1090 (49%), Gaps = 144/1090 (13%)

Query: 919  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 975
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449

Query: 976  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1027
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501

Query: 1028 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1072
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561

Query: 1073 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619

Query: 1129 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1184
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669

Query: 1185 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYASS 1240
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725

Query: 1241 PYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLF---------------- 1284
              S +    V P +Q +    +   G +  +++ I+I++ ++L                 
Sbjct: 726  GASTQNSNTVEPEKQVDNTVKM--AGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKL 783

Query: 1285 --KRKRTHSPSSKDEQSIGLKD-------------------------------------- 1304
              K+K T S + ++   +   D                                      
Sbjct: 784  AKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTL 843

Query: 1305 SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDP 1361
            ++  H   + DPVEM       P  +  P I + DL  +I ++K   G  F +EYE++  
Sbjct: 844  TIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE 898

Query: 1362 GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYI 1421
            GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SDYINANYIDGY +   YI
Sbjct: 899  GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYI 958

Query: 1422 ATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLD 1481
            ATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YWP   TE  G I+VTL++
Sbjct: 959  ATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIE 1017

Query: 1482 TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA 1541
            T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T +L F+R+VK  NP +A
Sbjct: 1018 TEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEA 1077

Query: 1542 GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIH 1601
            GP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R+QR  +VQTE+QYVF+H
Sbjct: 1078 GPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVH 1137

Query: 1602 EALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRF 1656
            +A+LEA  CG+T +P    R+LY +I +L    P  + + ++ EF+ L   + +      
Sbjct: 1138 DAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKDEFQTLNIVTPRVRPEDC 1194

Query: 1657 ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPL 1716
                LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL
Sbjct: 1195 SIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPL 1253

Query: 1717 AESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ 1776
              +  DFWR+++++N + +VML ++     + C QYWP + S  Y    V+ ++      
Sbjct: 1254 PNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDED 1311

Query: 1777 YILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQF-GQD 1832
             I R F++ +    Q   R ++  Q+  WP  +  P +    +  + ++ K +EQ+ G++
Sbjct: 1312 IIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGRE 1371

Query: 1833 GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892
            G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR  +  MV+T +QY+  Y
Sbjct: 1372 GRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVY 1431

Query: 1893 RAALEYLGSF 1902
              ALEYL SF
Sbjct: 1432 EVALEYLSSF 1441



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 100/413 (24%), Positives = 161/413 (38%), Gaps = 40/413 (9%)

Query: 564 TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623
           +++ ++ D    ++ +++   RSD G GV            TP APP+    +++G+T +
Sbjct: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE---LLAVGATYL 305

Query: 624 RVSWVPPPADS--RNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR 681
              W+ P A+S   +G I    V Y    G     H+VD  S  +  W L    ++ E R
Sbjct: 306 ---WIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVD--SPNYKLWHLDPDVEY-EIR 359

Query: 682 VWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQI 741
           V +    + G GP   P+  RT    P   P+ VE+  + +  + + W          + 
Sbjct: 360 VLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----------EP 409

Query: 742 RGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE--SEDYETTISGLTPETTYSVTVAA 799
            GY VT     N     L +    +  + Q+  EE        T+ GL P  T  + +  
Sbjct: 410 FGYAVTRCHSYN-----LTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLL 464

Query: 800 YTTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQY 857
              +G    S+  +V T   VPG  P   I        + +QW PP E  G +  Y + Y
Sbjct: 465 SNPEG-RMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINY 523

Query: 858 CRADEARPN---TIDFGK-----DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 909
                  P+   +   GK     ++ H    GL+ GTTY F + A    G G      I 
Sbjct: 524 KAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA 583

Query: 910 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 962
           T    PS  P+    T L  + T +         R   +  Y +V ++   Q+
Sbjct: 584 TKISAPS-MPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQK 635



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262

Query: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306

Query: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360

Query: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479

Query: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539

Query: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594

Query: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319

Query: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377

Query: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437

Query: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494

Query: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553

Query: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609

Query: 628 VPPPADSRNGVITQYSV 644
           +  PA SR   ++ Y +
Sbjct: 610 MLKPAQSRGAPVSVYQL 626



 Score = 68.6 bits (166), Expect = 6e-11
 Identities = 74/296 (25%), Positives = 113/296 (38%), Gaps = 52/296 (17%)

Query: 755  EPRGLPIIQD--VMLAEAQWRPEESEDYETTISG--------LTPETTYSVTVAAYTTKG 804
            +P    II D  ++L E ++R       ET I          L P+  Y + V   T  G
Sbjct: 308  KPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366

Query: 805  DGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859
            +G    P    TT       V G   + I         LQW P         GY +  C 
Sbjct: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP--------FGYAVTRCH 418

Query: 860  A-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 908
            +           ++ +    +  +   H+T+ GL    T   RL   N  G  E  E  +
Sbjct: 419  SYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478

Query: 909  RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---------DIN 959
            +T ED+P   P      G       + W PP   E NG I  Y + ++         D++
Sbjct: 479  QTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLS 536

Query: 960  SQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMP 1009
            SQ+ ++  +  +T     GL P TTY   ++A T+KG GP     ++  I + +MP
Sbjct: 537  SQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMP 592


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  506 bits (1303), Expect = e-143
 Identities = 300/778 (38%), Positives = 443/778 (56%), Gaps = 69/778 (8%)

Query: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1238
            Y AA+L    LPE   FT+GD + Y+GF+N PL+P   Y  +  A      + K      
Sbjct: 669  YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728

Query: 1239 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1291
               +  ++E  V   PA+Q +   ++  ++  +L  IL++L+VI I+    L K+++   
Sbjct: 729  ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788

Query: 1292 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1320
             +++ E +  +        D    H+ DP+ +  ++                        
Sbjct: 789  GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848

Query: 1321 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1370
                      YQT  +  HP I + DL  +I  +K +D   F +EYES   GQ  +W+ +
Sbjct: 849  RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906

Query: 1371 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1430
              + N+ KNRY N+IAYDHSRVIL  ++  P SDYINANYIDGY++ + YIATQGP+ ET
Sbjct: 907  KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHET 966

Query: 1431 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1490
            + DFWRM+W++++A +VM+T L E  RVKC +YWP   TE  G  +VT ++   LA Y V
Sbjct: 967  VYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVV 1025

Query: 1491 RTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA 1550
            RTF L + G +E RE++QF F  WPDHGVP + T +L+F+RRVK  NP  AGP+VVHCSA
Sbjct: 1026 RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSA 1085

Query: 1551 GVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC 1610
            G GRTGC+IVID ML+  + E  VDIY  V  +RS+R  MVQTE+QY+FIH+A+LEA  C
Sbjct: 1086 GAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC 1145

Query: 1611 GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLPCNKFKN 1668
            G T +P     A    + ++    + + ++ EF+ L S   +        A LP N  KN
Sbjct: 1146 GETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN 1205

Query: 1669 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1728
            R ++++P +     L  I G E S+YINA+ +D YRQ  A+I TQ PL  + +DFWR+++
Sbjct: 1206 RFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVY 1264

Query: 1729 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVT 1785
            ++  T IVML ++     + C QYWP E   RY    V+ M+   + ++   I R   +T
Sbjct: 1265 DYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLT 1322

Query: 1786 DARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITVHCSAGV 1843
              ++G    ++QFQ+  W   + VP +   F+  I QV K +E+  + +G   +HC  G 
Sbjct: 1323 RPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGG 1381

Query: 1844 GRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS 1901
            GR+G+F  + IV+E ++ + VVD+F  VKTLR  +P MV+  +QY+ CY  ALEYL S
Sbjct: 1382 GRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
           EV  G +    C+A G    + K W+    +    +++PV   +N+          L  V
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260

Query: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
            ++    Y CV  S  G  +   AQ+ V+  P+P  P  L+    T   + L  +S   +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
            P+    ++YR   T G + E   V    Y +  L P +EY  RVL       G G P  
Sbjct: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
            +  RT    P   P+ ++   + A  + V WE          GY +   +T +     +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
            +  HN + A  L          V  L P    SL+++     G      TI ++T + V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489

Query: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
           P   P         + +I L+W  P  P   I  YE+ Y +    D    V   P     
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
              ++ +    L P T Y+F + A +  G G  T  I   T  S P+ P  + +  S+  
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608

Query: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
           T   ++ +  PA ++   I+ Y +  E
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)

Query: 787  LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 841
            L P+T Y + V   T  G+G       P I  T  A P R   T+ I+        + W 
Sbjct: 353  LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410

Query: 842  PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 888
                   E LGY +  C               +E++ + +D         V  L   T  
Sbjct: 411  -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463

Query: 889  IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 947
              ++   N  G  E  E  I+T ED+P   P ++L  T        L W  P+  + NG 
Sbjct: 464  SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520

Query: 948  IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
            I  Y + +  I S           Q + N+   T      L P TTY   +RA T KG G
Sbjct: 521  ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580

Query: 998  P-----LSPSIQSRTMP 1009
            P     ++ +I + T+P
Sbjct: 581  PATAINVTTNISAPTLP 597



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 90/431 (20%), Positives = 150/431 (34%), Gaps = 41/431 (9%)

Query: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597
           II+ E+ Y        +      PT  Y L  L PDT Y  R  L    + G G+  P +
Sbjct: 323 IILKEVEYRMTSGSWTETHAVNAPT--YKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPL 380

Query: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657
             RT  + P   P+ +    + +  + V W     +         ++ Y    G +  + 
Sbjct: 381 ITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKA 440

Query: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEV 717
               +  +     +  L  +T   + +      G   ES   +++TDEDVP   P K   
Sbjct: 441 DCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQ 499

Query: 718 EPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEES 777
                  + + WK P+    +G I  Y+++Y  + + +P  +P+          W     
Sbjct: 500 GTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDP-AVPVAGPPQTVSNLWNSTHH 556

Query: 778 EDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTA 832
                    L P TTY   + A T KG G  +   + T   A       G    +  T  
Sbjct: 557 -----VFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETAT 611

Query: 833 MNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRL 892
             T LL+  P +     +  Y++     +E  P          H T         Y   +
Sbjct: 612 TITVLLR--PAQAKGAPISAYQIV---VEELHP----------HRTKREAGAMECYQVPV 656

Query: 893 AAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYT 952
             +N    G  +      P   P   P+    T     T +  W+PP LA R G    Y 
Sbjct: 657 TYQNAMSGGAPYYFAAELP---PGNLPEPAPFTVGDNRTYQGFWNPP-LAPRKG----YN 708

Query: 953 VVFRDINSQQE 963
           + F+ ++S ++
Sbjct: 709 IYFQAMSSVEK 719



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)

Query: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
           P   Y +RVL  T  G+G    P P +  +T+   P + P   +       RI + W  L
Sbjct: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413

Query: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
                R   + +     Y+   +E +   +  DP +  + +  L P T    ++   +  
Sbjct: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473

Query: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
           G      TI  +T +  P   P K +  +     + ++W  P     NG+ITQY ++Y +
Sbjct: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530

Query: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
           +   D    V        + W+      + L   T Y+ ++RA T  G GP ++ + V T
Sbjct: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589

Query: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
           +   P+ P  +     LN TA  +   L     +   I  YQ+    L
Sbjct: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  504 bits (1298), Expect = e-142
 Identities = 356/1107 (32%), Positives = 546/1107 (49%), Gaps = 159/1107 (14%)

Query: 919  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 975
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449

Query: 976  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1027
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501

Query: 1028 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1072
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561

Query: 1073 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619

Query: 1129 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1184
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669

Query: 1185 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYAS- 1239
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725

Query: 1240 SPYSDEIVVQVTP-------AQQQE----EPEM-----LWVTGPVLAVILIILIVIAILL 1283
            +P     V   TP       A  Q     EPE      + + G +  +++ I+I++ ++L
Sbjct: 726  APMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML 785

Query: 1284 F------------------KRKRTHSPSSKDEQSIGLKD--------------------- 1304
                               K+K T S + ++   +   D                     
Sbjct: 786  TIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQD 845

Query: 1305 -----------------SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERL 1344
                             ++  H   + DPVEM       P  +  P I + DL  +I ++
Sbjct: 846  VNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQM 900

Query: 1345 KANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSD 1404
            K   G  F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SD
Sbjct: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960

Query: 1405 YINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW 1464
            YINANYIDGY +   YIATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YW
Sbjct: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020

Query: 1465 PARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPT 1524
            P   TE  G I+VTL++T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T
Sbjct: 1021 PD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYAT 1079

Query: 1525 PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMR 1584
             +L F+R+VK  NP +AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R
Sbjct: 1080 GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1139

Query: 1585 SQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMEL 1641
            +QR  +VQTE+QYVF+H+A+LEA  CG+T +P    R+LY +I +L    P  + + ++ 
Sbjct: 1140 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKD 1196

Query: 1642 EFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1699
            EF+ L   + +          LP N  KNR ++++P +     L  + G E S+YINA+ 
Sbjct: 1197 EFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAAL 1255

Query: 1700 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1759
            +D ++Q  A++ TQ PL  +  DFWR+++++N + +VML ++     + C QYWP + S 
Sbjct: 1256 MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSG 1313

Query: 1760 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFI 1816
             Y    V+ ++       I R F++ +    Q   R ++  Q+  WP  +  P +    +
Sbjct: 1314 CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLL 1373

Query: 1817 DFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLR 1875
              + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR
Sbjct: 1374 KVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLR 1433

Query: 1876 TQRPAMVQTEDQYQLCYRAALEYLGSF 1902
              +  MV+T +QY+  Y  ALEYL SF
Sbjct: 1434 NNKSNMVETLEQYKFVYEVALEYLSSF 1460



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 100/413 (24%), Positives = 161/413 (38%), Gaps = 40/413 (9%)

Query: 564 TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623
           +++ ++ D    ++ +++   RSD G GV            TP APP+    +++G+T +
Sbjct: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE---LLAVGATYL 305

Query: 624 RVSWVPPPADS--RNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR 681
              W+ P A+S   +G I    V Y    G     H+VD  S  +  W L    ++ E R
Sbjct: 306 ---WIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVD--SPNYKLWHLDPDVEY-EIR 359

Query: 682 VWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQI 741
           V +    + G GP   P+  RT    P   P+ VE+  + +  + + W          + 
Sbjct: 360 VLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----------EP 409

Query: 742 RGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE--SEDYETTISGLTPETTYSVTVAA 799
            GY VT     N     L +    +  + Q+  EE        T+ GL P  T  + +  
Sbjct: 410 FGYAVTRCHSYN-----LTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLL 464

Query: 800 YTTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQY 857
              +G    S+  +V T   VPG  P   I        + +QW PP E  G +  Y + Y
Sbjct: 465 SNPEG-RMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINY 523

Query: 858 CRADEARPN---TIDFGK-----DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 909
                  P+   +   GK     ++ H    GL+ GTTY F + A    G G      I 
Sbjct: 524 KAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA 583

Query: 910 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 962
           T    PS  P+    T L  + T +         R   +  Y +V ++   Q+
Sbjct: 584 TKISAPS-MPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQK 635



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262

Query: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306

Query: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360

Query: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479

Query: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539

Query: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594

Query: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319

Query: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377

Query: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437

Query: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494

Query: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553

Query: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609

Query: 628 VPPPADSRNGVITQYSV 644
           +  PA SR   ++ Y +
Sbjct: 610 MLKPAQSRGAPVSVYQL 626



 Score = 68.6 bits (166), Expect = 6e-11
 Identities = 74/296 (25%), Positives = 113/296 (38%), Gaps = 52/296 (17%)

Query: 755  EPRGLPIIQD--VMLAEAQWRPEESEDYETTISG--------LTPETTYSVTVAAYTTKG 804
            +P    II D  ++L E ++R       ET I          L P+  Y + V   T  G
Sbjct: 308  KPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366

Query: 805  DGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859
            +G    P    TT       V G   + I         LQW P         GY +  C 
Sbjct: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP--------FGYAVTRCH 418

Query: 860  A-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 908
            +           ++ +    +  +   H+T+ GL    T   RL   N  G  E  E  +
Sbjct: 419  SYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478

Query: 909  RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---------DIN 959
            +T ED+P   P      G       + W PP   E NG I  Y + ++         D++
Sbjct: 479  QTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLS 536

Query: 960  SQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMP 1009
            SQ+ ++  +  +T     GL P TTY   ++A T+KG GP     ++  I + +MP
Sbjct: 537  SQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMP 592


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  499 bits (1286), Expect = e-141
 Identities = 300/784 (38%), Positives = 443/784 (56%), Gaps = 75/784 (9%)

Query: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1238
            Y AA+L    LPE   FT+GD + Y+GF+N PL+P   Y  +  A      + K      
Sbjct: 669  YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728

Query: 1239 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1291
               +  ++E  V   PA+Q +   ++  ++  +L  IL++L+VI I+    L K+++   
Sbjct: 729  ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788

Query: 1292 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1320
             +++ E +  +        D    H+ DP+ +  ++                        
Sbjct: 789  GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848

Query: 1321 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1370
                      YQT  +  HP I + DL  +I  +K +D   F +EYES   GQ  +W+ +
Sbjct: 849  RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906

Query: 1371 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIATQ 1424
              + N+ KNRY N+IAYDHSRVIL  ++  P SDYINANYID      GY++ + YIATQ
Sbjct: 907  KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQ 966

Query: 1425 GPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVE 1484
            GP+ ET+ DFWRM+W++++A +VM+T L E  RVKC +YWP   TE  G  +VT ++   
Sbjct: 967  GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEP 1025

Query: 1485 LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPM 1544
            LA Y VRTF L + G +E RE++QF F  WPDHGVP + T +L+F+RRVK  NP  AGP+
Sbjct: 1026 LAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPI 1085

Query: 1545 VVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
            VVHCSAG GRTGC+IVID ML+  + E  VDIY  V  +RS+R  MVQTE+QY+FIH+A+
Sbjct: 1086 VVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI 1145

Query: 1605 LEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLP 1662
            LEA  CG T +P     A    + ++    + + ++ EF+ L S   +        A LP
Sbjct: 1146 LEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLP 1205

Query: 1663 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1722
             N  KNR ++++P +     L  I G E S+YINA+ +D YRQ  A+I TQ PL  + +D
Sbjct: 1206 RNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKD 1264

Query: 1723 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYIL 1779
            FWR+++++  T IVML ++     + C QYWP E   RY    V+ M+   + ++   I 
Sbjct: 1265 FWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIF 1322

Query: 1780 REFKVTDARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITV 1837
            R   +T  ++G    ++QFQ+  W   + VP +   F+  I QV K +E+  + +G   +
Sbjct: 1323 RICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTII 1381

Query: 1838 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1897
            HC  G GR+G+F  + IV+E ++ + VVD+F  VKTLR  +P MV+  +QY+ CY  ALE
Sbjct: 1382 HCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441

Query: 1898 YLGS 1901
            YL S
Sbjct: 1442 YLES 1445



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
           EV  G +    C+A G    + K W+    +    +++PV   +N+          L  V
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260

Query: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
            ++    Y CV  S  G  +   AQ+ V+  P+P  P  L+    T   + L  +S   +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
            P+    ++YR   T G + E   V    Y +  L P +EY  RVL       G G P  
Sbjct: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
            +  RT    P   P+ ++   + A  + V WE          GY +   +T +     +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
            +  HN + A  L          V  L P    SL+++     G      TI ++T + V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489

Query: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
           P   P         + +I L+W  P  P   I  YE+ Y +    D    V   P     
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
              ++ +    L P T Y+F + A +  G G  T  I   T  S P+ P  + +  S+  
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608

Query: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
           T   ++ +  PA ++   I+ Y +  E
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)

Query: 787  LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 841
            L P+T Y + V   T  G+G       P I  T  A P R   T+ I+        + W 
Sbjct: 353  LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410

Query: 842  PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 888
                   E LGY +  C               +E++ + +D         V  L   T  
Sbjct: 411  -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463

Query: 889  IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 947
              ++   N  G  E  E  I+T ED+P   P ++L  T        L W  P+  + NG 
Sbjct: 464  SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520

Query: 948  IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
            I  Y + +  I S           Q + N+   T      L P TTY   +RA T KG G
Sbjct: 521  ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580

Query: 998  P-----LSPSIQSRTMP 1009
            P     ++ +I + T+P
Sbjct: 581  PATAINVTTNISAPTLP 597



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 90/431 (20%), Positives = 150/431 (34%), Gaps = 41/431 (9%)

Query: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597
           II+ E+ Y        +      PT  Y L  L PDT Y  R  L    + G G+  P +
Sbjct: 323 IILKEVEYRMTSGSWTETHAVNAPT--YKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPL 380

Query: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657
             RT  + P   P+ +    + +  + V W     +         ++ Y    G +  + 
Sbjct: 381 ITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKA 440

Query: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEV 717
               +  +     +  L  +T   + +      G   ES   +++TDEDVP   P K   
Sbjct: 441 DCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQ 499

Query: 718 EPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEES 777
                  + + WK P+    +G I  Y+++Y  + + +P  +P+          W     
Sbjct: 500 GTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDP-AVPVAGPPQTVSNLWNSTHH 556

Query: 778 EDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTA 832
                    L P TTY   + A T KG G  +   + T   A       G    +  T  
Sbjct: 557 -----VFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETAT 611

Query: 833 MNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRL 892
             T LL+  P +     +  Y++     +E  P          H T         Y   +
Sbjct: 612 TITVLLR--PAQAKGAPISAYQIV---VEELHP----------HRTKREAGAMECYQVPV 656

Query: 893 AAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYT 952
             +N    G  +      P   P   P+    T     T +  W+PP LA R G    Y 
Sbjct: 657 TYQNAMSGGAPYYFAAELP---PGNLPEPAPFTVGDNRTYQGFWNPP-LAPRKG----YN 708

Query: 953 VVFRDINSQQE 963
           + F+ ++S ++
Sbjct: 709 IYFQAMSSVEK 719



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)

Query: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
           P   Y +RVL  T  G+G    P P +  +T+   P + P   +       RI + W  L
Sbjct: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413

Query: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
                R   + +     Y+   +E +   +  DP +  + +  L P T    ++   +  
Sbjct: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473

Query: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
           G      TI  +T +  P   P K +  +     + ++W  P     NG+ITQY ++Y +
Sbjct: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530

Query: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
           +   D    V        + W+      + L   T Y+ ++RA T  G GP ++ + V T
Sbjct: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589

Query: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
           +   P+ P  +     LN TA  +   L     +   I  YQ+    L
Sbjct: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  498 bits (1281), Expect = e-140
 Identities = 279/629 (44%), Positives = 382/629 (60%), Gaps = 20/629 (3%)

Query: 1280 AILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLAD 1339
            AIL+     TH+ +S D  S+     + +H+    E   + YQT  +  HP I + DL  
Sbjct: 849  AILVPINDETHTMAS-DTSSL-----VQSHTYKKREPADVPYQTGQL--HPAIRVADLLQ 900

Query: 1340 NIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDG 1399
            +I ++K  +G  F +EYES   GQ   W+++  + N+ KNRY N+IAYDHSRV L +I+G
Sbjct: 901  HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960

Query: 1400 VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVK 1459
               SDYIN NYIDGY + N YIATQGP+ ET+ DFWRMVW + TA+++M+T L E  RVK
Sbjct: 961  DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020

Query: 1460 CDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGV 1519
            C +YWP   TE    I+VTL++T  LA Y +RTFA+ K G  E RE+RQF F  WPDHGV
Sbjct: 1021 CCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGV 1079

Query: 1520 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1579
            P + T +L F+R+VK+ +P  AGP+VVHCSAG GRTGCFIVID ML+  + E  VDIY  
Sbjct: 1080 PYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNC 1139

Query: 1580 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1639
            V  +RS+R  MVQTE+QYVFIH+A+LEA  CG T VPA  + +    + ++ P  + + +
Sbjct: 1140 VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQI 1199

Query: 1640 ELEFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINA 1697
            + EF+ L   +          A LP N  KNR ++I+P +     L  I G E S+YINA
Sbjct: 1200 KEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINA 1258

Query: 1698 SFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--- 1754
            + +D Y+Q  A+I TQ PL  + +DFWR++ +++ T +VML  +     + C QYWP   
Sbjct: 1259 ALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENG 1316

Query: 1755 AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWP-EQGVPKTGE 1813
              R    Q   V    E ++   I R +     +DG  R ++QFQF  WP  +  P +  
Sbjct: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKR 1375

Query: 1814 GFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVK 1872
             F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R++  VD+F  VK
Sbjct: 1376 SFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVK 1435

Query: 1873 TLRTQRPAMVQTEDQYQLCYRAALEYLGS 1901
            TLR  +P MV   DQY+ CY  ALEYL S
Sbjct: 1436 TLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464



 Score =  137 bits (346), Expect = 8e-32
 Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)

Query: 1375 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1434
            N  KNR  +++  D     L +IDG   S+YINA  +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284

Query: 1435 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1494
            WR+V +    +VVM+  ++      C QYWP  G    G IQV  +          R F 
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342

Query: 1495 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1546
            ++ +   +   R ++QFQF+ WP +   + P    +FL+ ++  +          G  VV
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1400

Query: 1547 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606
            HC  G GR+G F  I  + E ++H++TVD++  V  +R+ +  MV   DQY F +E  LE
Sbjct: 1401 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1460

Query: 1607 AATCG 1611
                G
Sbjct: 1461 YLNSG 1465



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295
           EV  G      C A+G  +   + W+ G +      KE ++   R  +   NVV +    
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254

Query: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345
              Y C+  +  G+ I   A++ VK   +PP+ +   +  +   T  W   N+       
Sbjct: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311

Query: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403
           P+    ++Y  A   G + +   V +T Y IG L P +EY   VL       G G P  A
Sbjct: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369

Query: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456
           +R RT    P   PR+++   + +  + ++WEP          Y   V+Y       +  
Sbjct: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429

Query: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515
           R   +W   N+      T+ +L P    S++++     G    S  + V+T + +P A P
Sbjct: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486

Query: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565
            +       + +I L W  P Q    I +YE+ Y A    D +  ++            +
Sbjct: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546

Query: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
            +    L P T Y F + A +  G G    T +  T  S PS P  ++    +  T   V
Sbjct: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604

Query: 626 SWVPPPADSRNGVITQYSVAYE 647
           + +  PA SR   ++ Y +  E
Sbjct: 605 TVMLKPAHSRGAPVSVYQIVVE 626



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 87/366 (23%), Positives = 135/366 (36%), Gaps = 60/366 (16%)

Query: 679  EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737
            +YR  +R  T+ G G  +   LV  +  VP  PP+   V      A +++ +L   S   
Sbjct: 257  KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309

Query: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQW---RPEESEDYETTISGLTPETTYS 794
             G I   +V Y                   A   W   +P +S  Y+  I  L P+T Y 
Sbjct: 310  DGPIVAREVEYCT-----------------ASGSWNDRQPVDSTSYK--IGHLDPDTEYE 350

Query: 795  VTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGE 849
            ++V   T  G+G    P     T       + G   + +         ++W P       
Sbjct: 351  ISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTR 409

Query: 850  LLGYRL--QYCR---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGE 902
               Y L   YC      E     + +  ++ H   T+T L   T    +L   N  G  E
Sbjct: 410  CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE 469

Query: 903  EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS-- 960
              E  ++T EDLP   P              L W  P   +  G I  Y + ++ ++S  
Sbjct: 470  SQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFD 527

Query: 961  -QQELQN-------ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRT 1007
             + +L N       +  +T F   GL P TTY   +RA T+KG GP      +  I + +
Sbjct: 528  PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587

Query: 1008 MPVEQV 1013
            MP  ++
Sbjct: 588  MPAYEL 593



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)

Query: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 970
            P   P+ L V  + +    + W+P        R  SY +       +  Q+++ + ++ D
Sbjct: 379  PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436

Query: 971  T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
            T     + T+T L P T   +K+     +G       I      +           +  +
Sbjct: 437  TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496

Query: 1026 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1070
              + L W  P  +Y     ++I Y   S    E+D           G+    L   L P 
Sbjct: 497  EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556

Query: 1071 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1130
            T YSF +  R S+A G                   PA+          SMP         
Sbjct: 557  TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590

Query: 1131 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1186
              Y +  P+++   +   ML P  S    + + +++  +E+  E  RR ++  E LK Y 
Sbjct: 591  --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644

Query: 1187 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1226
                             AA+         + FT+GD K Y G++N PL P  SY+ +  A
Sbjct: 645  VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704

Query: 1227 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1278
            + +   + K        + A++P       +  P  +++    + + G +  ++L ++I 
Sbjct: 705  ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757

Query: 1279 IAILLFKRKRTHSPSSKDEQS 1299
            + ++L  +KR  +   K+  S
Sbjct: 758  LGVVLVMKKRKLAKKRKETMS 778



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 74/302 (24%), Positives = 115/302 (38%), Gaps = 29/302 (9%)

Query: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531
           +G L P   Y + VL       G G P P ++ +T+   P + P   +       +I + 
Sbjct: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399

Query: 532 WLLPP----QERIIMYELV----YWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRF 580
           W   P      R   Y L     Y     E  + +V++D  +S+   T+ +L P T    
Sbjct: 400 W--EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSV 457

Query: 581 QLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT 640
           +L   +  G       I  +T +  P A P + +  S     + + W  P      GVIT
Sbjct: 458 KLILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVIT 514

Query: 641 QYSVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPE 695
            Y + Y+AV   D    + +   R       + +   GL   T Y   +RA T  G GP 
Sbjct: 515 LYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPP 574

Query: 696 SSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 755
           ++     T    PS P  ++E  PLN T   V   L     +   +  YQ+    +E   
Sbjct: 575 ATNQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEER 629

Query: 756 PR 757
           PR
Sbjct: 630 PR 631


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  496 bits (1277), Expect = e-140
 Identities = 271/601 (45%), Positives = 369/601 (61%), Gaps = 14/601 (2%)

Query: 1308 AHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTW 1367
            +H+    E   + YQT  +  HP I + DL  +I ++K  +G  F +EYES   GQ   W
Sbjct: 858  SHTYKKREPADVPYQTGQL--HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPW 915

Query: 1368 ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPL 1427
            +++  + N+ KNRY N+IAYDHSRV L +I+G   SDYIN NYIDGY + N YIATQGP+
Sbjct: 916  DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPM 975

Query: 1428 PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT 1487
             ET+ DFWRMVW + TA+++M+T L E  RVKC +YWP   TE    I+VTL++T  LA 
Sbjct: 976  QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAE 1034

Query: 1488 YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1547
            Y +RTFA+ K G  E RE+RQF F  WPDHGVP + T +L F+R+VK+ +P  AGP+VVH
Sbjct: 1035 YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVH 1094

Query: 1548 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1607
            CSAG GRTGCFIVID ML+  + E  VDIY  V  +RS+R  MVQTE+QYVFIH+A+LEA
Sbjct: 1095 CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA 1154

Query: 1608 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRFISANLPCNK 1665
              CG T VPA  + +    + ++ P  + + ++ EF+ L   +          A LP N 
Sbjct: 1155 CLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNH 1214

Query: 1666 FKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1725
             KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL  + +DFWR
Sbjct: 1215 EKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR 1273

Query: 1726 MLWEHNSTIIVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREF 1782
            ++ +++ T +VML  +     + C QYWP     R    Q   V    E ++   I R +
Sbjct: 1274 LVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIY 1331

Query: 1783 KVTDARDGQSRTIRQFQFTDWP-EQGVPKTGEGFIDFIGQVHKTKEQF-GQDGPITVHCS 1840
                 +DG  R ++QFQF  WP  +  P +   F+  I QV K +E++ G +G   VHC 
Sbjct: 1332 NAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390

Query: 1841 AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG 1900
             G GR+G F  +SIV E +R++  VD+F  VKTLR  +P MV   DQY+ CY  ALEYL 
Sbjct: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450

Query: 1901 S 1901
            S
Sbjct: 1451 S 1451



 Score =  137 bits (346), Expect = 8e-32
 Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)

Query: 1375 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1434
            N  KNR  +++  D     L +IDG   S+YINA  +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271

Query: 1435 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1494
            WR+V +    +VVM+  ++      C QYWP  G    G IQV  +          R F 
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329

Query: 1495 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1546
            ++ +   +   R ++QFQF+ WP +   + P    +FL+ ++  +          G  VV
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1387

Query: 1547 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606
            HC  G GR+G F  I  + E ++H++TVD++  V  +R+ +  MV   DQY F +E  LE
Sbjct: 1388 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1447

Query: 1607 AATCG 1611
                G
Sbjct: 1448 YLNSG 1452



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295
           EV  G      C A+G  +   + W+ G +      KE ++   R  +   NVV +    
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254

Query: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345
              Y C+  +  G+ I   A++ VK   +PP+ +   +  +   T  W   N+       
Sbjct: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311

Query: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403
           P+    ++Y  A   G + +   V +T Y IG L P +EY   VL       G G P  A
Sbjct: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369

Query: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456
           +R RT    P   PR+++   + +  + ++WEP          Y   V+Y       +  
Sbjct: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429

Query: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515
           R   +W   N+      T+ +L P    S++++     G    S  + V+T + +P A P
Sbjct: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486

Query: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565
            +       + +I L W  P Q    I +YE+ Y A    D +  ++            +
Sbjct: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546

Query: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
            +    L P T Y F + A +  G G    T +  T  S PS P  ++    +  T   V
Sbjct: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604

Query: 626 SWVPPPADSRNGVITQYSVAYE 647
           + +  PA SR   ++ Y +  E
Sbjct: 605 TVMLKPAHSRGAPVSVYQIVVE 626



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 87/366 (23%), Positives = 135/366 (36%), Gaps = 60/366 (16%)

Query: 679  EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737
            +YR  +R  T+ G G  +   LV  +  VP  PP+   V      A +++ +L   S   
Sbjct: 257  KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309

Query: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQW---RPEESEDYETTISGLTPETTYS 794
             G I   +V Y                   A   W   +P +S  Y+  I  L P+T Y 
Sbjct: 310  DGPIVAREVEYCT-----------------ASGSWNDRQPVDSTSYK--IGHLDPDTEYE 350

Query: 795  VTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGE 849
            ++V   T  G+G    P     T       + G   + +         ++W P       
Sbjct: 351  ISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTR 409

Query: 850  LLGYRL--QYCR---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGE 902
               Y L   YC      E     + +  ++ H   T+T L   T    +L   N  G  E
Sbjct: 410  CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE 469

Query: 903  EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS-- 960
              E  ++T EDLP   P              L W  P   +  G I  Y + ++ ++S  
Sbjct: 470  SQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFD 527

Query: 961  -QQELQN-------ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRT 1007
             + +L N       +  +T F   GL P TTY   +RA T+KG GP      +  I + +
Sbjct: 528  PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587

Query: 1008 MPVEQV 1013
            MP  ++
Sbjct: 588  MPAYEL 593



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)

Query: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 970
            P   P+ L V  + +    + W+P        R  SY +       +  Q+++ + ++ D
Sbjct: 379  PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436

Query: 971  T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
            T     + T+T L P T   +K+     +G       I      +           +  +
Sbjct: 437  TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496

Query: 1026 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1070
              + L W  P  +Y     ++I Y   S    E+D           G+    L   L P 
Sbjct: 497  EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556

Query: 1071 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1130
            T YSF +  R S+A G                   PA+          SMP         
Sbjct: 557  TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590

Query: 1131 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1186
              Y +  P+++   +   ML P  S    + + +++  +E+  E  RR ++  E LK Y 
Sbjct: 591  --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644

Query: 1187 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1226
                             AA+         + FT+GD K Y G++N PL P  SY+ +  A
Sbjct: 645  VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704

Query: 1227 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1278
            + +   + K        + A++P       +  P  +++    + + G +  ++L ++I 
Sbjct: 705  ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757

Query: 1279 IAILLFKRKRTHSPSSKDEQS 1299
            + ++L  +KR  +   K+  S
Sbjct: 758  LGVVLVMKKRKLAKKRKETMS 778



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 74/302 (24%), Positives = 115/302 (38%), Gaps = 29/302 (9%)

Query: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531
           +G L P   Y + VL       G G P P ++ +T+   P + P   +       +I + 
Sbjct: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399

Query: 532 WLLPP----QERIIMYELV----YWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRF 580
           W   P      R   Y L     Y     E  + +V++D  +S+   T+ +L P T    
Sbjct: 400 W--EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSV 457

Query: 581 QLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT 640
           +L   +  G       I  +T +  P A P + +  S     + + W  P      GVIT
Sbjct: 458 KLILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVIT 514

Query: 641 QYSVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPE 695
            Y + Y+AV   D    + +   R       + +   GL   T Y   +RA T  G GP 
Sbjct: 515 LYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPP 574

Query: 696 SSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 755
           ++     T    PS P  ++E  PLN T   V   L     +   +  YQ+    +E   
Sbjct: 575 ATNQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEER 629

Query: 756 PR 757
           PR
Sbjct: 630 PR 631


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  464 bits (1195), Expect = e-130
 Identities = 342/1078 (31%), Positives = 513/1078 (47%), Gaps = 123/1078 (11%)

Query: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 968
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 969  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500

Query: 1026 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1070
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560

Query: 1071 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1127
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619

Query: 1128 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1185
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663

Query: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1237
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723

Query: 1238 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1283
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV 783

Query: 1284 -FKRKRTHSPSSKD-----------EQSIGLK---------------------DSLLAHS 1310
             +++++TH  S+ D           ++ +GL                       SLL  S
Sbjct: 784  NYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS 843

Query: 1311 SD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1369
               P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES   G    W+ 
Sbjct: 844  PRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDA 897

Query: 1370 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1429
            +  +     +R   + AYD  RV L  + G P +DYINANYIDGY + N +IATQGP PE
Sbjct: 898  TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPE 957

Query: 1430 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYT 1489
             + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L+ T  LA Y 
Sbjct: 958  MVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYV 1016

Query: 1490 VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCS 1549
            VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P DAGP+V+HCS
Sbjct: 1017 VRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCS 1076

Query: 1550 AGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT 1609
            AG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+FIH+A+LEA  
Sbjct: 1077 AGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL 1136

Query: 1610 CGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLPCNKFK 1667
            CG T +P     A  +++ ++ P  + + +  EF+ L S            A LP N+ K
Sbjct: 1137 CGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDK 1196

Query: 1668 NRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1725
            NR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  +T DFWR
Sbjct: 1197 NRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWR 1253

Query: 1726 MLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1784
            +++++  T IVML +L +      C QYWP     +Y    V+ M+       + R F+V
Sbjct: 1254 LVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRV 1313

Query: 1785 TDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSA 1841
             +    Q     +R FQF  W   +  P + + F+  + +V K + + G DG   VHC  
Sbjct: 1314 QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLN 1372

Query: 1842 GVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1899
            G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  CY  ALEYL
Sbjct: 1373 GGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439

Query: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616

Query: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
            R   I+ Y V  E    E+R R +
Sbjct: 617 GRGAPISVYQVIVE----EERARRL 637



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 69/265 (26%), Positives = 107/265 (40%), Gaps = 27/265 (10%)

Query: 566 SYTLEDLKPDTLYRFQ--LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623
           +Y L  L PDT Y     L    D G G   P + +RT  + P   P+ +    + +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 624 RVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT----- 678
            + W P   +         S+ Y    G    + + + +  E       G+ ++T     
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ------GVSRYTIKNLL 454

Query: 679 EYR-VWVR-AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVH--VYWKLPVP 734
            YR V VR   T+     E   V  +TDEDVPSG    +  E L  T +   ++ K   P
Sbjct: 455 PYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP 510

Query: 735 SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYS 794
            + +G I  Y+++Y  +E+ +P       +V           +E Y    S L P TTY 
Sbjct: 511 QEPNGLITQYEISYQSIESSDP-----AVNVPGPRRTISKLRNETYH-VFSNLHPGTTYL 564

Query: 795 VTVAAYTTKGDGARSKPKIVTTTGA 819
            +V A T KG G  +  +I T   A
Sbjct: 565 FSVRARTGKGFGQAALTEITTNISA 589



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 73/273 (26%), Positives = 104/273 (38%), Gaps = 47/273 (17%)

Query: 760 PIIQ---DVMLAEAQWRPEESEDYET-TISGLTPETTYSVTVAAYTTKGDGARSKPK--- 812
           PI++   +  +A   W    +   +T  +  L P+T Y ++V   T  GDG   +P    
Sbjct: 316 PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLL-TRPGDGGTGRPGPPL 374

Query: 813 IVTTTGAVPGRPTMMISTTAMNTA--LLQWHPPKELPGELLGYRLQYCRA---------- 860
           I  T  A P R    ++   +      LQW P        LGY +  C            
Sbjct: 375 ISRTKCAEPMRAPKGLAFAEIQARQLTLQWEP--------LGYNVTRCHTYTVSLCYHYT 426

Query: 861 -DEARPNTI-DFGKDDQ---HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 915
              +   TI +  K +Q    +T+  L        RL   N  G  E  E   +T ED+P
Sbjct: 427 LGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVP 486

Query: 916 SGFP-QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT------ 968
           SG   ++L  T L      L W+ P   E NG I  Y + ++ I S     N+       
Sbjct: 487 SGIAAESLTFTPLEDMIF-LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTI 543

Query: 969 ----TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
                +T    + L P TTY   VRA T KG G
Sbjct: 544 SKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564

Query: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621

Query: 544 ELVYWAAEDEDQQHKVTFDP 563
             VY    +E++  ++  +P
Sbjct: 622 ISVYQVIVEEERARRLRREP 641



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 79/360 (21%), Positives = 124/360 (34%), Gaps = 49/360 (13%)

Query: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314

Query: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369

Query: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419

Query: 754 --------GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
                   G      I + V   +   R         TI  L P     V +     +G 
Sbjct: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSR--------YTIKNLLPYRNVHVRLVLTNPEGR 471

Query: 806 GARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEAR 864
               +    T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + 
Sbjct: 472 KEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSD 531

Query: 865 P--------NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 916
           P         TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 532 PAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 34/151 (22%), Positives = 62/151 (41%), Gaps = 11/151 (7%)

Query: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
           S YT+++L P      +L   +  G       +  +T +  PS    + +  +     + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKE-GKEVTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRG------RHVVDGISREHSSWDLVGLEKWT 678
           + W  P     NG+ITQY ++Y++++  D        R  +  + R  +      L   T
Sbjct: 505 LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL-RNETYHVFSNLHPGT 561

Query: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPS 709
            Y   VRA T  G G +++   + T+   PS
Sbjct: 562 TYLFSVRARTGKGFG-QAALTEITTNISAPS 591


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  461 bits (1185), Expect = e-129
 Identities = 342/1088 (31%), Positives = 513/1088 (47%), Gaps = 133/1088 (12%)

Query: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 968
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 969  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500

Query: 1026 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1070
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560

Query: 1071 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1127
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619

Query: 1128 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1185
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663

Query: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1237
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723

Query: 1238 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1283
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYP 783

Query: 1284 -----------FKRKRTHSPSSKD-----------EQSIGLK------------------ 1303
                       +++++TH  S+ D           ++ +GL                   
Sbjct: 784  KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGV 843

Query: 1304 ---DSLLAHSSD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI 1359
                SLL  S   P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES 
Sbjct: 844  TEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESF 901

Query: 1360 DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNA 1419
              G    W+ +  +     +R   + AYD  RV L  + G P +DYINANYIDGY + N 
Sbjct: 902  FEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNH 957

Query: 1420 YIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL 1479
            +IATQGP PE + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L
Sbjct: 958  FIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIML 1016

Query: 1480 LDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL 1539
            + T  LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P 
Sbjct: 1017 VKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPP 1076

Query: 1540 DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF 1599
            DAGP+V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+F
Sbjct: 1077 DAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF 1136

Query: 1600 IHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFI 1657
            IH+A+LEA  CG T +P     A  +++ ++ P  + + +  EF+ L S           
Sbjct: 1137 IHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECS 1196

Query: 1658 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGP 1715
             A LP N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  P
Sbjct: 1197 IALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHP 1253

Query: 1716 LAESTEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNM 1774
            L  +T DFWR+++++  T IVML +L +      C QYWP     +Y    V+ M+    
Sbjct: 1254 LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTAD 1313

Query: 1775 PQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQ 1831
               + R F+V +    Q     +R FQF  W   +  P + + F+  + +V K + + G 
Sbjct: 1314 EDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG- 1372

Query: 1832 DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLC 1891
            DG   VHC  G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  C
Sbjct: 1373 DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFC 1432

Query: 1892 YRAALEYL 1899
            Y  ALEYL
Sbjct: 1433 YDVALEYL 1440



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439

Query: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616

Query: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
            R   I+ Y V  E    E+R R +
Sbjct: 617 GRGAPISVYQVIVE----EERARRL 637



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 69/265 (26%), Positives = 107/265 (40%), Gaps = 27/265 (10%)

Query: 566 SYTLEDLKPDTLYRFQ--LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623
           +Y L  L PDT Y     L    D G G   P + +RT  + P   P+ +    + +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 624 RVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT----- 678
            + W P   +         S+ Y    G    + + + +  E       G+ ++T     
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ------GVSRYTIKNLL 454

Query: 679 EYR-VWVR-AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVH--VYWKLPVP 734
            YR V VR   T+     E   V  +TDEDVPSG    +  E L  T +   ++ K   P
Sbjct: 455 PYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP 510

Query: 735 SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYS 794
            + +G I  Y+++Y  +E+ +P       +V           +E Y    S L P TTY 
Sbjct: 511 QEPNGLITQYEISYQSIESSDP-----AVNVPGPRRTISKLRNETYH-VFSNLHPGTTYL 564

Query: 795 VTVAAYTTKGDGARSKPKIVTTTGA 819
            +V A T KG G  +  +I T   A
Sbjct: 565 FSVRARTGKGFGQAALTEITTNISA 589



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 73/273 (26%), Positives = 104/273 (38%), Gaps = 47/273 (17%)

Query: 760 PIIQ---DVMLAEAQWRPEESEDYET-TISGLTPETTYSVTVAAYTTKGDGARSKPK--- 812
           PI++   +  +A   W    +   +T  +  L P+T Y ++V   T  GDG   +P    
Sbjct: 316 PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLL-TRPGDGGTGRPGPPL 374

Query: 813 IVTTTGAVPGRPTMMISTTAMNTA--LLQWHPPKELPGELLGYRLQYCRA---------- 860
           I  T  A P R    ++   +      LQW P        LGY +  C            
Sbjct: 375 ISRTKCAEPMRAPKGLAFAEIQARQLTLQWEP--------LGYNVTRCHTYTVSLCYHYT 426

Query: 861 -DEARPNTI-DFGKDDQ---HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 915
              +   TI +  K +Q    +T+  L        RL   N  G  E  E   +T ED+P
Sbjct: 427 LGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVP 486

Query: 916 SGFP-QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT------ 968
           SG   ++L  T L      L W+ P   E NG I  Y + ++ I S     N+       
Sbjct: 487 SGIAAESLTFTPLEDMIF-LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTI 543

Query: 969 ----TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
                +T    + L P TTY   VRA T KG G
Sbjct: 544 SKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564

Query: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621

Query: 544 ELVYWAAEDEDQQHKVTFDP 563
             VY    +E++  ++  +P
Sbjct: 622 ISVYQVIVEEERARRLRREP 641



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 79/360 (21%), Positives = 124/360 (34%), Gaps = 49/360 (13%)

Query: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314

Query: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369

Query: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419

Query: 754 --------GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
                   G      I + V   +   R         TI  L P     V +     +G 
Sbjct: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSR--------YTIKNLLPYRNVHVRLVLTNPEGR 471

Query: 806 GARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEAR 864
               +    T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + 
Sbjct: 472 KEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSD 531

Query: 865 P--------NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 916
           P         TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 532 PAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 34/151 (22%), Positives = 62/151 (41%), Gaps = 11/151 (7%)

Query: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
           S YT+++L P      +L   +  G       +  +T +  PS    + +  +     + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKE-GKEVTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRG------RHVVDGISREHSSWDLVGLEKWT 678
           + W  P     NG+ITQY ++Y++++  D        R  +  + R  +      L   T
Sbjct: 505 LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL-RNETYHVFSNLHPGT 561

Query: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPS 709
            Y   VRA T  G G +++   + T+   PS
Sbjct: 562 TYLFSVRARTGKGFG-QAALTEITTNISAPS 591


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  458 bits (1178), Expect = e-128
 Identities = 342/1084 (31%), Positives = 513/1084 (47%), Gaps = 129/1084 (11%)

Query: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 968
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 969  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500

Query: 1026 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1070
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560

Query: 1071 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1127
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619

Query: 1128 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1185
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663

Query: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1237
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723

Query: 1238 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1283
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV 783

Query: 1284 -FKRKRTHSPSSKD-----------EQSIGLK---------------------DSLLAHS 1310
             +++++TH  S+ D           ++ +GL                       SLL  S
Sbjct: 784  NYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS 843

Query: 1311 SD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1369
               P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES   G    W+ 
Sbjct: 844  PRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDA 897

Query: 1370 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIAT 1423
            +  +     +R   + AYD  RV L  + G P +DYINANYID      GY + N +IAT
Sbjct: 898  TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIAT 957

Query: 1424 QGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTV 1483
            QGP PE + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L+ T 
Sbjct: 958  QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTE 1016

Query: 1484 ELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGP 1543
             LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P DAGP
Sbjct: 1017 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1076

Query: 1544 MVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEA 1603
            +V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+FIH+A
Sbjct: 1077 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1136

Query: 1604 LLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANL 1661
            +LEA  CG T +P     A  +++ ++ P  + + +  EF+ L S            A L
Sbjct: 1137 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1196

Query: 1662 PCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAES 1719
            P N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  +
Sbjct: 1197 PRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQST 1253

Query: 1720 TEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1778
            T DFWR+++++  T IVML +L +      C QYWP     +Y    V+ M+       +
Sbjct: 1254 TPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLV 1313

Query: 1779 LREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835
             R F+V +    Q     +R FQF  W   +  P + + F+  + +V K + + G DG  
Sbjct: 1314 ARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRT 1372

Query: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895
             VHC  G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  CY  A
Sbjct: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432

Query: 1896 LEYL 1899
            LEYL
Sbjct: 1433 LEYL 1436



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439

Query: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616

Query: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
            R   I+ Y V  E    E+R R +
Sbjct: 617 GRGAPISVYQVIVE----EERARRL 637



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 69/265 (26%), Positives = 107/265 (40%), Gaps = 27/265 (10%)

Query: 566 SYTLEDLKPDTLYRFQ--LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623
           +Y L  L PDT Y     L    D G G   P + +RT  + P   P+ +    + +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 624 RVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT----- 678
            + W P   +         S+ Y    G    + + + +  E       G+ ++T     
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ------GVSRYTIKNLL 454

Query: 679 EYR-VWVR-AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVH--VYWKLPVP 734
            YR V VR   T+     E   V  +TDEDVPSG    +  E L  T +   ++ K   P
Sbjct: 455 PYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP 510

Query: 735 SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYS 794
            + +G I  Y+++Y  +E+ +P       +V           +E Y    S L P TTY 
Sbjct: 511 QEPNGLITQYEISYQSIESSDP-----AVNVPGPRRTISKLRNETYH-VFSNLHPGTTYL 564

Query: 795 VTVAAYTTKGDGARSKPKIVTTTGA 819
            +V A T KG G  +  +I T   A
Sbjct: 565 FSVRARTGKGFGQAALTEITTNISA 589



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 73/273 (26%), Positives = 104/273 (38%), Gaps = 47/273 (17%)

Query: 760 PIIQ---DVMLAEAQWRPEESEDYET-TISGLTPETTYSVTVAAYTTKGDGARSKPK--- 812
           PI++   +  +A   W    +   +T  +  L P+T Y ++V   T  GDG   +P    
Sbjct: 316 PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLL-TRPGDGGTGRPGPPL 374

Query: 813 IVTTTGAVPGRPTMMISTTAMNTA--LLQWHPPKELPGELLGYRLQYCRA---------- 860
           I  T  A P R    ++   +      LQW P        LGY +  C            
Sbjct: 375 ISRTKCAEPMRAPKGLAFAEIQARQLTLQWEP--------LGYNVTRCHTYTVSLCYHYT 426

Query: 861 -DEARPNTI-DFGKDDQ---HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 915
              +   TI +  K +Q    +T+  L        RL   N  G  E  E   +T ED+P
Sbjct: 427 LGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVP 486

Query: 916 SGFP-QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT------ 968
           SG   ++L  T L      L W+ P   E NG I  Y + ++ I S     N+       
Sbjct: 487 SGIAAESLTFTPLEDMIF-LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTI 543

Query: 969 ----TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
                +T    + L P TTY   VRA T KG G
Sbjct: 544 SKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564

Query: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621

Query: 544 ELVYWAAEDEDQQHKVTFDP 563
             VY    +E++  ++  +P
Sbjct: 622 ISVYQVIVEEERARRLRREP 641



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 79/360 (21%), Positives = 124/360 (34%), Gaps = 49/360 (13%)

Query: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314

Query: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369

Query: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419

Query: 754 --------GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
                   G      I + V   +   R         TI  L P     V +     +G 
Sbjct: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSR--------YTIKNLLPYRNVHVRLVLTNPEGR 471

Query: 806 GARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEAR 864
               +    T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + 
Sbjct: 472 KEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSD 531

Query: 865 P--------NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 916
           P         TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 532 PAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 34/151 (22%), Positives = 62/151 (41%), Gaps = 11/151 (7%)

Query: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
           S YT+++L P      +L   +  G       +  +T +  PS    + +  +     + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKE-GKEVTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRG------RHVVDGISREHSSWDLVGLEKWT 678
           + W  P     NG+ITQY ++Y++++  D        R  +  + R  +      L   T
Sbjct: 505 LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL-RNETYHVFSNLHPGT 561

Query: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPS 709
            Y   VRA T  G G +++   + T+   PS
Sbjct: 562 TYLFSVRARTGKGFG-QAALTEITTNISAPS 591


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  446 bits (1146), Expect = e-124
 Identities = 350/1152 (30%), Positives = 526/1152 (45%), Gaps = 143/1152 (12%)

Query: 815  TTTGAVPGRPTMMISTTAMNTALLQ--WHPPKEL-PGELLGYRLQYCRADEARPNTIDFG 871
            T    V   P + +    +N   LQ  W  P+ +    ++ Y + Y            F 
Sbjct: 340  TEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFT 399

Query: 872  KD---DQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHV-TGL 927
            KD   D   T++ +   + Y+FR+ A  R  +  +F + +    +    F     V TG+
Sbjct: 400  KDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGV 459

Query: 928  TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIK 987
             T++   + D   ++  +    S  + F  ++    +   ++ ++ T+  +   T     
Sbjct: 460  PTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTST----- 514

Query: 988  VRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAA---MKTSVLLSWEVPDSYKSAVPF 1044
            + A    G G +S S  S   P     A +    AA   + T+  L+   PD   S  P 
Sbjct: 515  LLAGLGFGGGGIS-SFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSS--PT 571

Query: 1045 KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIR--TAPDLLPH 1102
            K   +G+  E      +    D +   E      +      G+ H    R  T P   P 
Sbjct: 572  K---DGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPS 628

Query: 1103 KPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDEL 1162
             P   +    +G       H QD +         VP D+ GG                  
Sbjct: 629  SPNRTA----EGGHQTIPGHEQDHT--------AVPTDQTGG------------------ 658

Query: 1163 LEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQC 1222
                         RR     L P +     V P T T   ++ Y G  + P  P++    
Sbjct: 659  -------------RRDAGPGLDPDMVTSTQV-PPTAT---EEQYAG--SDPKRPEMPS-- 697

Query: 1223 FVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEP--------EMLWVTGPVLAV--- 1271
                  K+PM +    S    D   + V PA++             M W+  P++ V   
Sbjct: 698  ------KKPMSRGDRFSE---DSRFITVNPAEKNTSGMISRPAPGRMEWII-PLIVVSAL 747

Query: 1272 -ILIILIVIAILL------------FKRKRTHSPSSKDEQSIGLKDSL-LAH------SS 1311
              + ++++IA+L+            F R+    PSS +    G +     AH      SS
Sbjct: 748  TFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSS 807

Query: 1312 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID---PGQQFTWE 1368
              V         P   D   IP+     +I  L +N+   FS+++E +         T E
Sbjct: 808  PRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAE 867

Query: 1369 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGP 1426
            +SN   NK KNRY N++AYDHSRV L  + G     SDYINANY+DGY K  AYIATQGP
Sbjct: 868  HSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGP 927

Query: 1427 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1486
            L  T  DFWRM+WEQ T  +VM+T L EK R KCDQYWP   +E  G I VTL  T   A
Sbjct: 928  LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA 987

Query: 1487 TYTVRTFALHKS-----------GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKA 1535
             YTVR F++  +           G   +R + Q+ +  WPD GVPEY  P+L F+RR  A
Sbjct: 988  CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA 1047

Query: 1536 CNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTED 1595
                + GP++VHCSAGVGRTG +IVID+ML+++K + TV++ G +  +R+QRNY+VQTE+
Sbjct: 1048 ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEE 1107

Query: 1596 QYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSR 1655
            QY+FIH+ALLEA     TEV +  L++++  +  +P     T +E +FKL+    A    
Sbjct: 1108 QYIFIHDALLEAILGKETEVSSNQLHSYVNSI-LIPGVGGKTRLEKQFKLVTQCNAKYVE 1166

Query: 1656 FISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGP 1715
              SA   CNK KNR  +++P E  RV L P+ G++G+DYINAS++ GY +   +I TQ P
Sbjct: 1167 CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHP 1226

Query: 1716 LAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPM 1769
            L  +T+DFWRM+W+HN+ IIVML   + +  ++   YWP+ E S   + F V     D +
Sbjct: 1227 LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRL 1285

Query: 1770 AEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF 1829
               N  Q I+ +F +   +D     +R FQ   WP    P +     + I  +   +E  
Sbjct: 1286 CLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEAL 1341

Query: 1830 GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQ 1889
             +DGP  VH   G    G+   L+ + +++  E  VD+FQ  K +   RP +    +QYQ
Sbjct: 1342 TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQ 1401

Query: 1890 LCYRAALEYLGS 1901
              Y+A L  + +
Sbjct: 1402 FIYKAMLSLVST 1413



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 12/93 (12%)

Query: 707 VPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM 766
           V S PP  ++V+PLN TA+ V W  P  +  H  I  Y ++Y   +N + +         
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEK--------- 394

Query: 767 LAEAQWRPEESEDYETTISGLTPETTYSVTVAA 799
             E  +  +  +D + TIS ++P++ Y   V A
Sbjct: 395 --EKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 24/138 (17%)

Query: 515 PADFQAEVESDTRIQLSWLLPP---QERIIMYELVYWAAEDEDQQHKVTF----DPTSSY 567
           P   + +  + T +Q+SW  P       I+ Y + Y   ++ED++ K TF    D     
Sbjct: 350 PIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEK-TFTKDSDKDLKA 408

Query: 568 TLEDLKPDTLYRFQLAA------RSDMGVGVFTPTIEARTAQST-------PSAPPQK-- 612
           T+  + PD+LY F++ A      RSD    +       R  Q T       P+A P    
Sbjct: 409 TISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSA 468

Query: 613 -VMCVSMGSTTVRVSWVP 629
            +  +S GS+T   S +P
Sbjct: 469 DMAPISSGSSTWTSSGIP 486


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  422 bits (1084), Expect = e-117
 Identities = 264/727 (36%), Positives = 386/727 (53%), Gaps = 52/727 (7%)

Query: 1201 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1260
            GD +   GF   P SP  S    V +   E        +S  S E  + +    + E+  
Sbjct: 1585 GDSEITPGF---PQSPTSS----VTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA 1637

Query: 1261 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1320
            ++ +        + +++++ IL++ RK   +     E S   +  +++    P+      
Sbjct: 1638 VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR--VISTPPTPI------ 1689

Query: 1321 YQTPGMRDHPPIPITDLADNIERLKANDGL--------KFSQEYESIDPGQQFTWENSNL 1372
               P   D   IPI     ++  L A+ G         +F QE +S       T ++SN 
Sbjct: 1690 --FPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNH 1747

Query: 1373 EVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGPLPET 1430
              NK KNRY N++AYDHSRV L  +    G  +DYINANY+DGY +  AYIA QGPL  T
Sbjct: 1748 PDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKST 1807

Query: 1431 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1490
              DFWRM+WE     +VM+T L EK R KCDQYWPA G+E  G   VT      LA YTV
Sbjct: 1808 AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTV 1867

Query: 1491 RTFALH----KSGSSEKRE----LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAG 1542
            R F L     K GS + R     + Q+ +  WPD GVPEY  P+L F+R+         G
Sbjct: 1868 RNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG 1927

Query: 1543 PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE 1602
            P+VVHCSAGVGRTG +IV+D+ML++++HE TV+I+G +  +RSQRNY+VQTE+QYVFIH+
Sbjct: 1928 PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD 1987

Query: 1603 ALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLP 1662
             L+EA     TEV   +++A++  L  +P     T +E +F+LL+ S    S + +A   
Sbjct: 1988 TLVEAILSKETEVLDSHIHAYVNAL-LIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQ 2046

Query: 1663 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1722
            CN+ KNR  +I+P E +RV +  + G EG+DYINAS++ GY Q   +I TQ PL  + +D
Sbjct: 2047 CNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKD 2105

Query: 1723 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQ 1776
            FWRM+W+HN+ ++VM+   + M  ++   YWP  +     + F V  MAE      N  +
Sbjct: 2106 FWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEK 2164

Query: 1777 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDFIGQVHKTKEQFGQDGP 1834
             I+++F +   +D     +R FQ   WP    P  KT E  I  I      +E   +DGP
Sbjct: 2165 LIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFE-LISVI-----KEEAANRDGP 2218

Query: 1835 ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRA 1894
            + VH   G    G F  L+ ++ ++  E  VD++Q  K +   RP +    +QYQ  Y+ 
Sbjct: 2219 MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV 2278

Query: 1895 ALEYLGS 1901
             L  + +
Sbjct: 2279 ILSLVST 2285



 Score =  119 bits (298), Expect = 3e-26
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 10/264 (3%)

Query: 1363 QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIA 1422
            QQ  +  +  + N+ KNR +++I  + SRV ++S+ G  G+DYINA+YI GY + N +I 
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094

Query: 1423 TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLD 1481
            TQ PL  T+ DFWRM+W+     VVM+   +  +  +   YWP +     C   +VTL+ 
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153

Query: 1482 TVELATYT-----VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC 1536
                         ++ F L  +      E+R FQ   WP+   P   T  L  + + +A 
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213

Query: 1537 NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ 1596
            N    GPM+VH   G    G F  +  ++ +++ E +VD+Y     +   R  +    +Q
Sbjct: 2214 NR--DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271

Query: 1597 YVFIHEALLEAATCGHTEVPARNL 1620
            Y F+++ +L   +    E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 536  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 581

Query: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1386
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 582  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 638

Query: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 639  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 698

Query: 1447 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1503
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 699  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 758

Query: 1504 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1563
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 759  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 818

Query: 1564 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1623
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 819  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 878

Query: 1624 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1683
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 879  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 937

Query: 1684 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1724
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 938  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 997

Query: 1725 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1784
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 998  QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 1056

Query: 1785 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1836
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 1057 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116

Query: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172



 Score =  197 bits (500), Expect = 1e-49
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681

Query: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1776
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741

Query: 1777 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799

Query: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1896 LEY 1898
            +EY
Sbjct: 860  VEY 862



 Score =  156 bits (395), Expect = 2e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 1371 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1411
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 914  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 973

Query: 1412 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1471
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 974  MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 1032

Query: 1472 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1531
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 1033 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1092

Query: 1532 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1581
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 1093 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1152

Query: 1582 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1619
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1153 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1190


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 584  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 629

Query: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1386
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 630  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 686

Query: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 687  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 746

Query: 1447 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1503
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 747  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 806

Query: 1504 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1563
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 807  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 866

Query: 1564 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1623
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 867  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 926

Query: 1624 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1683
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 927  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 985

Query: 1684 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1724
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 986  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 1045

Query: 1725 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1784
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 1046 QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 1104

Query: 1785 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1836
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 1105 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1164

Query: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1165 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220



 Score =  197 bits (500), Expect = 1e-49
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 670  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729

Query: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1776
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 730  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789

Query: 1777 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 790  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847

Query: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1896 LEY 1898
            +EY
Sbjct: 908  VEY 910



 Score =  156 bits (395), Expect = 2e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 1371 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1411
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 962  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 1021

Query: 1412 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1471
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 1022 MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 1080

Query: 1472 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1531
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 1081 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1140

Query: 1532 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1581
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 1141 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1200

Query: 1582 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1619
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1201 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1238


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 423  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 468

Query: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1386
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 469  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 525

Query: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 526  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 585

Query: 1447 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1503
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 586  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 645

Query: 1504 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1563
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 646  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 705

Query: 1564 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1623
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 706  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 765

Query: 1624 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1683
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 766  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 824

Query: 1684 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1724
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 825  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 884

Query: 1725 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1784
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 885  QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 943

Query: 1785 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1836
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 944  RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003

Query: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059



 Score =  197 bits (500), Expect = 1e-49
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 509  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568

Query: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1776
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 569  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628

Query: 1777 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 629  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686

Query: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1896 LEY 1898
            +EY
Sbjct: 747  VEY 749



 Score =  156 bits (395), Expect = 2e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 1371 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1411
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 801  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 860

Query: 1412 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1471
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 861  MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 919

Query: 1472 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1531
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 920  YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 979

Query: 1532 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1581
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 980  VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1039

Query: 1582 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1619
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1040 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1077


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,517,515
Number of Sequences: 37866
Number of extensions: 3897335
Number of successful extensions: 22970
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 350
Number of HSP's successfully gapped in prelim test: 216
Number of HSP's that attempted gapping in prelim test: 10408
Number of HSP's gapped (non-prelim): 4223
length of query: 1907
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1790
effective length of database: 13,817,196
effective search space: 24732780840
effective search space used: 24732780840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.