Search of human proteins with 109633039

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109633039 protein tyrosine phosphatase, receptor type, F
isoform 2 precursor [Homo sapiens]
         (1898 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109633039 protein tyrosine phosphatase, receptor type, F isof...  3838   0.0  
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...  3830   0.0  
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...  2703   0.0  
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...  2697   0.0  
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...  2690   0.0  
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...  2572   0.0  
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...  2538   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...  1451   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...  1445   0.0  
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...  1405   0.0  
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...  1405   0.0  
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   609   e-174
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   609   e-174
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   609   e-174
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   566   e-161
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   551   e-156
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   510   e-144
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   506   e-143
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   504   e-142
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   499   e-141
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   496   e-140
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   464   e-130
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   461   e-129
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   458   e-128
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   446   e-124
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   422   e-117
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110

>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score = 3838 bits (9952), Expect = 0.0
 Identities = 1898/1898 (100%), Positives = 1898/1898 (100%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
            NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS
Sbjct: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240

Query: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
            QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
Sbjct: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300

Query: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
            ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360

Query: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
            GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
            QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP
Sbjct: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480

Query: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
            GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI
Sbjct: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540

Query: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
            IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR
Sbjct: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600

Query: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
            TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD
Sbjct: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660

Query: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
            GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL
Sbjct: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720

Query: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP 780
            NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP
Sbjct: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP 780

Query: 781  ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGE 840
            ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGE
Sbjct: 781  ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGE 840

Query: 841  LLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 900
            LLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR
Sbjct: 841  LLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 900

Query: 901  TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITT 960
            TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITT
Sbjct: 901  TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITT 960

Query: 961  DTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVL 1020
            DTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVL
Sbjct: 961  DTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVL 1020

Query: 1021 LSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQH 1080
            LSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQH
Sbjct: 1021 LSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQH 1080

Query: 1081 LVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTP 1140
            LVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTP
Sbjct: 1081 LVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTP 1140

Query: 1141 RWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGF 1200
            RWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGF
Sbjct: 1141 RWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGF 1200

Query: 1201 YNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVL 1260
            YNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVL
Sbjct: 1201 YNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVL 1260

Query: 1261 AVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH 1320
            AVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH
Sbjct: 1261 AVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH 1320

Query: 1321 PPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDH 1380
            PPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDH
Sbjct: 1321 PPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDH 1380

Query: 1381 SRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM 1440
            SRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
Sbjct: 1381 SRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM 1440

Query: 1441 TRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQF 1500
            TRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQF
Sbjct: 1441 TRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQF 1500

Query: 1501 QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMK 1560
            QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMK
Sbjct: 1501 QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMK 1560

Query: 1561 HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ 1620
            HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ
Sbjct: 1561 HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ 1620

Query: 1621 VPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV 1680
            VPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV
Sbjct: 1621 VPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV 1680

Query: 1681 EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC 1740
            EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC
Sbjct: 1681 EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC 1740

Query: 1741 HQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP 1800
            HQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP
Sbjct: 1741 HQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP 1800

Query: 1801 KTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQ 1860
            KTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQ
Sbjct: 1801 KTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQ 1860

Query: 1861 TVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            TVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT
Sbjct: 1861 TVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score = 3830 bits (9932), Expect = 0.0
 Identities = 1898/1907 (99%), Positives = 1898/1907 (99%), Gaps = 9/1907 (0%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
            NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS
Sbjct: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240

Query: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
            QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
Sbjct: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300

Query: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
            ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360

Query: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
            GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
            QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP
Sbjct: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480

Query: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
            GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI
Sbjct: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540

Query: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
            IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR
Sbjct: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600

Query: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
            TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD
Sbjct: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660

Query: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
            GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL
Sbjct: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720

Query: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ--------- 771
            NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ         
Sbjct: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780

Query: 772  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 831
            ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW
Sbjct: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 840

Query: 832  HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 891
            HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL
Sbjct: 841  HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 900

Query: 892  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS 951
            GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS
Sbjct: 901  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS 960

Query: 952  QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1011
            QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV
Sbjct: 961  QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1020

Query: 1012 AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR 1071
            AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR
Sbjct: 1021 AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR 1080

Query: 1072 GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID 1131
            GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID
Sbjct: 1081 GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID 1140

Query: 1132 RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL 1191
            RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL
Sbjct: 1141 RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL 1200

Query: 1192 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1251
            GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE
Sbjct: 1201 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1260

Query: 1252 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1311
            MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN
Sbjct: 1261 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1320

Query: 1312 YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR 1371
            YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR
Sbjct: 1321 YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR 1380

Query: 1372 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE 1431
            YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE
Sbjct: 1381 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE 1440

Query: 1432 QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS 1491
            QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS
Sbjct: 1441 QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS 1500

Query: 1492 SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1551
            SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV
Sbjct: 1501 SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560

Query: 1552 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL 1611
            IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL
Sbjct: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL 1620

Query: 1612 YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR 1671
            YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR
Sbjct: 1621 YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR 1680

Query: 1672 VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK 1731
            VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK
Sbjct: 1681 VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK 1740

Query: 1732 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1791
            LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF
Sbjct: 1741 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1800

Query: 1792 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR 1851
            TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR
Sbjct: 1801 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR 1860

Query: 1852 YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT
Sbjct: 1861 YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score = 2703 bits (7007), Expect = 0.0
 Identities = 1335/1897 (70%), Positives = 1563/1897 (82%), Gaps = 22/1897 (1%)

Query: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESS 197
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSGALQIE S
Sbjct: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQS 188

Query: 198  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVG 257
            EESDQGKYECVATNSAGTRYSAPANLYVRVRRV PRFSIPP++ E+MPGGSVN+TCVAVG
Sbjct: 189  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVG 248

Query: 258  APMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317
            +PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+IEA AQ+TVKA
Sbjct: 249  SPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKA 308

Query: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377
            LPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++E+DGVATTRYS+ 
Sbjct: 309  LPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVA 368

Query: 378  GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
            GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARMLS++T+LVQW+ P
Sbjct: 369  GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 428

Query: 438  EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
            EEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TYS++VLAFT++GDG
Sbjct: 429  EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 488

Query: 498  PPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQH 557
            P S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YELVY   E  ++Q 
Sbjct: 489  PLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQ- 547

Query: 558  KVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS 617
            ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS PSAPPQ + C S
Sbjct: 548  RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607

Query: 618  MGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKW 677
              ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  + + + L  LEKW
Sbjct: 608  PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667

Query: 678  TEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQ 737
            TEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+V V W+ PVP+KQ
Sbjct: 668  TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727

Query: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ----ETT-----ISGLTPETTYSVTV 788
            HGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ    +TT     ISGL PET+YS+TV
Sbjct: 728  HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787

Query: 789  AAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQY 848
             AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP +  G L GYRL++
Sbjct: 788  TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 847

Query: 849  CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSG 908
             R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE  KEI  PE++P+G
Sbjct: 848  GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG 907

Query: 909  FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ---QELQNITTDTRFT 965
            FPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN      E   +  DT  T
Sbjct: 908  FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 967

Query: 966  LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEV 1025
            LTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V A MKTSVLLSWE+
Sbjct: 968  LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEI 1027

Query: 1026 PDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVS 1083
            P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL NRG+SAGGLQH V+
Sbjct: 1028 PENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1087

Query: 1084 IRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWS 1143
             +TAPD+L  KP        DG   + +P V     ++ +YI++VP+ +  G  + P W 
Sbjct: 1088 AKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP-WE 1146

Query: 1144 TPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNR 1203
            +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FTLGD K+Y GF N+
Sbjct: 1147 SPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNK 1204

Query: 1204 PLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QEEPEMLWVTGPVLA 1261
             L     Y  FVLA + E  + K YA+SPYSD +V      Q    EE  ++WV GPVLA
Sbjct: 1205 QLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 1263

Query: 1262 VILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHP 1321
            V+ II IVIAILL+KRKR  S S K       K+    H +DPVE+RRLN+QTPGM  HP
Sbjct: 1264 VVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQTPGMASHP 1322

Query: 1322 PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHS 1381
            PIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHS
Sbjct: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHS 1382

Query: 1382 RVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT 1441
            RV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM+WEQR+ATVVMMT
Sbjct: 1383 RVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1442

Query: 1442 RLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQ 1501
            +LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K+GSSEKRE+RQFQ
Sbjct: 1443 KLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQ 1502

Query: 1502 FMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH 1561
            F AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGCFIVIDAMLER+KH
Sbjct: 1503 FTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH 1562

Query: 1562 EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQV 1621
            EKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPARNLYA+IQKL Q+
Sbjct: 1563 EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI 1622

Query: 1622 PPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVE 1681
              GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVE
Sbjct: 1623 ETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE 1682

Query: 1682 GSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH 1741
            GSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VMLTKLREMGREKCH
Sbjct: 1683 GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH 1742

Query: 1742 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK 1801
            QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK
Sbjct: 1743 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK 1802

Query: 1802 TGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT 1861
            +GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQT
Sbjct: 1803 SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQT 1862

Query: 1862 VKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            VK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1863 VKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score = 2697 bits (6991), Expect = 0.0
 Identities = 1333/1901 (70%), Positives = 1561/1901 (82%), Gaps = 26/1901 (1%)

Query: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188

Query: 190  -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
             GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 189  RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 245  PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
            PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 249  PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308

Query: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
            G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 309  GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 365  EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
            E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 425  LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
            LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 429  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488

Query: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
            S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 489  SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548

Query: 545  LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
            LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 549  LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 605  TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
             PSAPPQ + C S  ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  
Sbjct: 608  KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667

Query: 665  EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
            + + + L  LEKWTEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 668  DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727

Query: 725  VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTY 784
            V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ+  ISGL PET+Y
Sbjct: 728  VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSY 787

Query: 785  SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGY 844
            S+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP +  G L GY
Sbjct: 788  SLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 847

Query: 845  RLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPED 904
            RL++ R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE  KEI  PE+
Sbjct: 848  RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE 907

Query: 905  LPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ---QELQNITTD 961
            +P+GFPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN      E   +  D
Sbjct: 908  VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 967

Query: 962  TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLL 1021
            T  TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V A MKTSVLL
Sbjct: 968  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLL 1027

Query: 1022 SWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQ 1079
            SWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL NRG+SAGGLQ
Sbjct: 1028 SWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQ 1087

Query: 1080 HLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLT 1139
            H V+ +TAPD+L  KP        DG   + +P V     ++ +YI++VP+ +  G  + 
Sbjct: 1088 HRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIK 1147

Query: 1140 PRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRG 1199
            P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FTLGD K+Y G
Sbjct: 1148 P-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFTLGDDKHYGG 1204

Query: 1200 FYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QEEPEMLWVTG 1257
            F N+ L     Y  FVLA + E  + K YA+SPYSD +V      Q    EE  ++WV G
Sbjct: 1205 FTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVG 1263

Query: 1258 PVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGM 1317
            PVLAV+ II IVIAILL+KRKR  S S K       K+    H +DPVE+RRLN+QTPGM
Sbjct: 1264 PVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQTPGM 1322

Query: 1318 RDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIA 1377
              HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIA
Sbjct: 1323 ASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA 1382

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM+WEQR+ATV
Sbjct: 1383 YDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATV 1442

Query: 1438 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKREL 1497
            VMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K+GSSEKRE+
Sbjct: 1443 VMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREV 1502

Query: 1498 RQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLE 1557
            RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGCFIVIDAMLE
Sbjct: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562

Query: 1558 RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK 1617
            R+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPARNLYA+IQK
Sbjct: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622

Query: 1618 LGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPI 1677
            L Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPI
Sbjct: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1682

Query: 1678 RGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGR 1737
            RGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VMLTKLREMGR
Sbjct: 1683 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1742

Query: 1738 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQ 1797
            EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQ
Sbjct: 1743 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQ 1802

Query: 1798 GVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1857
            GVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD
Sbjct: 1803 GVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1862

Query: 1858 MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            +FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1863 IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score = 2690 bits (6972), Expect = 0.0
 Identities = 1335/1910 (69%), Positives = 1563/1910 (81%), Gaps = 35/1910 (1%)

Query: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188

Query: 190  -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
             GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 189  RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 245  PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
            PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 249  PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308

Query: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
            G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 309  GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 365  EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
            E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 425  LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
            LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 429  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488

Query: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
            S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 489  SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548

Query: 545  LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
            LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 549  LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 605  TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
             PSAPPQ + C S  ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  
Sbjct: 608  KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667

Query: 665  EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
            + + + L  LEKWTEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 668  DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727

Query: 725  VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ----ETT-----I 775
            V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ    +TT     I
Sbjct: 728  VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMII 787

Query: 776  SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 835
            SGL PET+YS+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP 
Sbjct: 788  SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV 847

Query: 836  ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 895
            +  G L GYRL++ R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE 
Sbjct: 848  DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM 907

Query: 896  EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--- 952
             KEI  PE++P+GFPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN     
Sbjct: 908  VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 967

Query: 953  QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1012
             E   +  DT  TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V 
Sbjct: 968  MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVK 1027

Query: 1013 AAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMN 1070
            A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL N
Sbjct: 1028 AVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN 1087

Query: 1071 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1130
            RG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++ +YI++VP+
Sbjct: 1088 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPL 1147

Query: 1131 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFT 1190
             +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FT
Sbjct: 1148 KKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFT 1204

Query: 1191 LGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QE 1248
            LGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V      Q    E
Sbjct: 1205 LGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDE 1263

Query: 1249 EPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMR 1308
            E  ++WV GPVLAV+ II IVIAILL+KRKR  S S K       K+    H +DPVE+R
Sbjct: 1264 EEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELR 1322

Query: 1309 RLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKP 1368
            RLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKP
Sbjct: 1323 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKP 1382

Query: 1369 KNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM 1428
            KNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM
Sbjct: 1383 KNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRM 1442

Query: 1429 VWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK 1488
            +WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K
Sbjct: 1443 IWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK 1502

Query: 1489 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGC 1548
            +GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGC
Sbjct: 1503 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1562

Query: 1549 FIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA 1608
            FIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPA
Sbjct: 1563 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1622

Query: 1609 RNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1668
            RNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1623 RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1682

Query: 1669 LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM 1728
             TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VM
Sbjct: 1683 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1742

Query: 1729 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQ 1788
            LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQ
Sbjct: 1743 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1802

Query: 1789 FQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE 1848
            FQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLE
Sbjct: 1803 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1862

Query: 1849 RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            RMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1863 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 2572 bits (6666), Expect = 0.0
 Identities = 1301/1918 (67%), Positives = 1500/1918 (78%), Gaps = 28/1918 (1%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
            NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181  NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240

Query: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
             E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANYTCVA
Sbjct: 241  HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300

Query: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
            +SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++   +
Sbjct: 301  MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360

Query: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
            GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S PR V
Sbjct: 361  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420

Query: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
            QARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVGSLL 
Sbjct: 421  QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
              TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P QE I
Sbjct: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540

Query: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
            I YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP +  R
Sbjct: 541  IKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599

Query: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
            T QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y  +  ED     V+
Sbjct: 600  TLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVN 659

Query: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720
            GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDVPS PPRKVE E L
Sbjct: 660  GIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEAL 719

Query: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP 780
            N+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVMLA+AQE  I+ L P
Sbjct: 720  NATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQP 779

Query: 781  ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK-ELPG 839
            ET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ +  T   + L +W PP      
Sbjct: 780  ETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAED 839

Query: 840  ELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899
            ++LGYRLQ+ R D     T++F   +  +T +G+HKG TY+FRLAA++R GLGEE  + +
Sbjct: 840  QVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 899

Query: 900  RTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERNGRIISYTVVFRDINS-----QQ 953
              PED P G PQ L   G  +  T  L W PPV AERNG I+ YTV  R+  +     + 
Sbjct: 900  SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARET 959

Query: 954  ELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFR 1010
            EL        +   TL GLKPDT YD++VRA T +G GP SP ++ RT   +QV  KNF+
Sbjct: 960  ELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFK 1019

Query: 1011 VAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMN 1070
            V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+P+T Y+FVL N
Sbjct: 1020 VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTN 1079

Query: 1071 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1130
            RGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  V+ ++IV+VP+
Sbjct: 1080 RGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPL 1139

Query: 1131 DRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETF 1189
             +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+AA+  VLP TF
Sbjct: 1140 RKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTF 1198

Query: 1190 TLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEE 1249
              GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   +     Q   +
Sbjct: 1199 HPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLDNPDPQPIVD 1256

Query: 1250 PE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA-------H 1300
             E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      LL        H
Sbjct: 1257 GEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLLNNADLAPHH 1312

Query: 1301 SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1360
              DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYESIDPGQQFTWE+
Sbjct: 1313 PKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEH 1372

Query: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1420
            SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QNAYIATQGPLPE
Sbjct: 1373 SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPE 1432

Query: 1421 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYT 1480
            T GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLLDT+ELAT+ 
Sbjct: 1433 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFC 1492

Query: 1481 VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCS 1540
            VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VVHCS
Sbjct: 1493 VRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCS 1552

Query: 1541 AGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT 1600
            AGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLEA  
Sbjct: 1553 AGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVG 1612

Query: 1601 CGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNR 1660
            CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISANLPCNKFKNR
Sbjct: 1613 CGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNR 1672

Query: 1661 LVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWE 1720
            LVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWE
Sbjct: 1673 LVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1732

Query: 1721 HNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD 1780
            +NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
Sbjct: 1733 NNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD 1792

Query: 1781 GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVF 1840
            GQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVF
Sbjct: 1793 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1852

Query: 1841 ITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            ITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYAT
Sbjct: 1853 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 2538 bits (6578), Expect = 0.0
 Identities = 1300/1956 (66%), Positives = 1499/1956 (76%), Gaps = 66/1956 (3%)

Query: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRS---------GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----V 227
            NGRIKQLRS         GALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR    V
Sbjct: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240

Query: 228  RRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLEL 287
            RRVAPRFSI P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL
Sbjct: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300

Query: 288  SNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPV 347
            ++V  SANYTCVA+SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV
Sbjct: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360

Query: 348  TYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407
            +YY I+Y++   +GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  R
Sbjct: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420

Query: 408  TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT 467
            TGEQAP+S PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN 
Sbjct: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480

Query: 468  DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527
            D  LLTTVGSLL   TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T 
Sbjct: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540

Query: 528  IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSD 587
            I LSW  P QE II YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS 
Sbjct: 541  ITLSWSPPRQESIIKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 599

Query: 588  MGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYE 647
             G+G FTP +  RT QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y 
Sbjct: 600  QGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYR 659

Query: 648  AVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDV 707
             +  ED     V+GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDV
Sbjct: 660  PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDV 719

Query: 708  PSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVML 767
            PS PPRKVE E LN+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVML
Sbjct: 720  PSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVML 779

Query: 768  AEAQ---------ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM 818
            A+AQ         E  I+ L PET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ 
Sbjct: 780  ADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS 839

Query: 819  ISTTAMNTALLQWHPPK-ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGT 877
            +  T   + L +W PP      ++LGYRLQ+ R D     T++F   +  +T +G+HKG 
Sbjct: 840  VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGA 899

Query: 878  TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERN 936
            TY+FRLAA++R GLGEE  + +  PED P G PQ L   G  +  T  L W PPV AERN
Sbjct: 900  TYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959

Query: 937  GRIISYTVVFRDINS-----QQELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988
            G I+ YTV  R+  +     + EL        +   TL GLKPDT YD++VRA T +G G
Sbjct: 960  GAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG 1019

Query: 989  PLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDG 1048
            P SP ++ RT   +QV  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG
Sbjct: 1020 PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDG 1079

Query: 1049 HSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFD 1108
             + +KLI  L+P+T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   
Sbjct: 1080 RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 1139

Query: 1109 LSMPHVQDPSLVRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRR 1167
            + +P  Q P  V+ ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R 
Sbjct: 1140 VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRH 1198

Query: 1168 RRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKR 1227
             RQ E  +PY+AA+  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  
Sbjct: 1199 SRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPT 1256

Query: 1228 YASSPYSDEIVVQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSS 1285
            +A+SP+SD   +     Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P S
Sbjct: 1257 FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDS 1312

Query: 1286 KDEQSIGLKDSLLA-------HSSDPVEMRRLNYQTP----------------GMRDHPP 1322
            K + S      LL        H  DPVEMRR+N+QTP                 M  HPP
Sbjct: 1313 KRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPP 1372

Query: 1323 IPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSR 1382
            IPI D+A++ ERLKAND LK SQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSR
Sbjct: 1373 IPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1432

Query: 1383 VILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTR 1442
            VIL  I+G+ GSDYINANY+DGYR QNAYIATQGPLPET GDFWRMVWEQR+AT+VMMTR
Sbjct: 1433 VILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492

Query: 1443 LEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1502
            LEEKSR+KCDQYWP RGTET G IQVTLLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF
Sbjct: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552

Query: 1503 MAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE 1562
             AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VVHCSAGVGRTGCFIVIDAMLER+K E
Sbjct: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE 1612

Query: 1563 KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVP 1622
            KTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLEA  CG+TEVPAR+LYA+IQKL QV 
Sbjct: 1613 KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVE 1672

Query: 1623 PGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG 1682
            PGE VT MELEFK LA+SKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEG
Sbjct: 1673 PGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1732

Query: 1683 SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ 1742
            SDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQ
Sbjct: 1733 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ 1792

Query: 1743 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKT 1802
            YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+
Sbjct: 1793 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1852

Query: 1803 GEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTV 1862
            GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQTV
Sbjct: 1853 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTV 1912

Query: 1863 KTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            K LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYAT
Sbjct: 1913 KMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score = 1451 bits (3755), Expect = 0.0
 Identities = 758/1199 (63%), Positives = 893/1199 (74%), Gaps = 33/1199 (2%)

Query: 711  PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
            PP    V    +T++ + W    P           V+Y  +++       + +++     
Sbjct: 325  PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 375

Query: 771  QETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TAL 828
               +++GL+P + Y   V A    G G  S+P +  T+   P      +    ++  T L
Sbjct: 376  TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 435

Query: 829  LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAK 886
            +QW  P+E  G++ GYR+ Y        N        D Q  T+  L    TY  ++ A 
Sbjct: 436  VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 495

Query: 887  NRAGLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVV 945
               G G    + ++ T   +P G P N      + ++  L+W PP    R+  I +Y +V
Sbjct: 496  TSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELV 550

Query: 946  FRDINSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQ 1003
            ++D    +E Q IT +  T + L GLKP++ Y  ++ A + +G G  +  I +RTM  + 
Sbjct: 551  YKDGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QS 607

Query: 1004 VFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPN 1061
            +FAKNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P 
Sbjct: 608  MFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPE 667

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
              YSFVL NRG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++
Sbjct: 668  KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIK 727

Query: 1122 WFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQ 1181
             +YI++VP+ +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA 
Sbjct: 728  GYYIIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAH 784

Query: 1182 LDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQV 1241
             DVLP  FTLGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V   
Sbjct: 785  FDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMD 843

Query: 1242 TPAQQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA 1299
               Q    EE  ++WV GPVLAV+ II IVIAILL+KRKR  S S K       K+    
Sbjct: 844  LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSH 902

Query: 1300 HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWE 1359
            H +DPVE+RRLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE
Sbjct: 903  HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 962

Query: 1360 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP 1419
            +SNLEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LP
Sbjct: 963  HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1022

Query: 1420 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY 1479
            ET GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY
Sbjct: 1023 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1082

Query: 1480 TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHC 1539
             VRTFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHC
Sbjct: 1083 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1142

Query: 1540 SAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA 1599
            SAGVGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA 
Sbjct: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202

Query: 1600 TCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKN 1659
            TCG+TEVPARNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKN
Sbjct: 1203 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1262

Query: 1660 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1719
            RLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLW
Sbjct: 1263 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1322

Query: 1720 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1779
            EHNSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR
Sbjct: 1323 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1382

Query: 1780 DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGV 1839
            DGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGV
Sbjct: 1383 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1442

Query: 1840 FITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
            FITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1443 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501



 Score =  804 bits (2077), Expect = 0.0
 Identities = 404/626 (64%), Positives = 496/626 (79%), Gaps = 17/626 (2%)

Query: 18  LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
           L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9   LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78  FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
           FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69  FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
           DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188

Query: 190 -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
            GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 189 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 245 PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
           PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 249 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308

Query: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
           G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368

Query: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
           E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428

Query: 425 LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
           LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488

Query: 485 SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
           S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 489 SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548

Query: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
           LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 549 LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 605 TPSAPPQKVMCVSMGSTTVRVSWVPP 630
             +   +     ++  T+V +SW  P
Sbjct: 608 MFA---KNFHVKAVMKTSVLLSWEIP 630



 Score =  147 bits (371), Expect = 1e-34
 Identities = 121/425 (28%), Positives = 196/425 (46%), Gaps = 34/425 (8%)

Query: 580  FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
            +   A S +GV      I   T ++ P  P   V+  S  +T++ ++W     DS N   
Sbjct: 300  YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 350

Query: 640  TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
              Y +        +     +DG++   + + + GL  +++Y   V A  ++G GP S PV
Sbjct: 351  VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408

Query: 700  LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
            L +T E  PS  PR V+   L+ST + V WK   P + +GQI+GY+V Y        + +
Sbjct: 409  LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYTM---DPTQHV 463

Query: 760  PIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMI 819
                   +A++Q TTI  L P+ TYSV V A+T+ GDG  S    V T   VPG+P    
Sbjct: 464  NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 523

Query: 820  STTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTT 878
            +     T+ LL W PP+     +  Y L Y   +      I   +    + + GL   + 
Sbjct: 524  AEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSYRLQGLKPNSL 580

Query: 879  YIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG 937
            Y FRLAA++  GLG    E   RT   + S F +N HV  +  ++  L+W+ P   E   
Sbjct: 581  YYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSWEIP---ENYN 634

Query: 938  RIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG--SGPLSPSIQ 995
              + + +++ D    +E+    T     +  LKP+ +Y   +   T++G  +G L   + 
Sbjct: 635  SAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGNSAGGLQHRVT 689

Query: 996  SRTMP 1000
            ++T P
Sbjct: 690  AKTAP 694


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score = 1445 bits (3741), Expect = 0.0
 Identities = 754/1202 (62%), Positives = 892/1202 (74%), Gaps = 35/1202 (2%)

Query: 711  PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
            PP    V    +T++ + W    P           V+Y  +++       + +++     
Sbjct: 322  PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 372

Query: 771  QETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TAL 828
               +++GL+P + Y   V A    G G  S+P +  T+   P      +    ++  T L
Sbjct: 373  TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 432

Query: 829  LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAK 886
            +QW  P+E  G++ GYR+ Y        N        D Q  T+  L    TY  ++ A 
Sbjct: 433  VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 492

Query: 887  NRAGLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVV 945
               G G    + ++ T   +P G P N      + ++  L+W PP    R+  I +Y +V
Sbjct: 493  TSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELV 547

Query: 946  FRDINSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQ 1003
            ++D    +E Q IT +  T + L GLKP++ Y  ++ A + +G G  +  I +RTM  + 
Sbjct: 548  YKDGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QS 604

Query: 1004 VFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPN 1061
            +FAKNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P 
Sbjct: 605  MFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPE 664

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
              YSFVL NRG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++
Sbjct: 665  KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIK 724

Query: 1122 WFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQ 1181
             +YI++VP+ +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA 
Sbjct: 725  GYYIIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAH 781

Query: 1182 LDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQV 1241
             DVLP  FTLGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V   
Sbjct: 782  FDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMD 840

Query: 1242 TPAQQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGL---KDS 1296
               Q    EE  ++WV GPVLAV+ II IVIAILL+K K     +  D +   +   K+ 
Sbjct: 841  LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900

Query: 1297 LLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQF 1356
               H +DPVE+RRLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQF
Sbjct: 901  PSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF 960

Query: 1357 TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQG 1416
            TWE+SNLEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG
Sbjct: 961  TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG 1020

Query: 1417 PLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVEL 1476
             LPET GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVEL
Sbjct: 1021 SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVEL 1080

Query: 1477 ATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMV 1536
            ATY VRTFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMV
Sbjct: 1081 ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMV 1140

Query: 1537 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1596
            VHCSAGVGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALL
Sbjct: 1141 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200

Query: 1597 EAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNK 1656
            EA TCG+TEVPARNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNK
Sbjct: 1201 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNK 1260

Query: 1657 FKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1716
            FKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWR
Sbjct: 1261 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1320

Query: 1717 MLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT 1776
            MLWEHNSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT
Sbjct: 1321 MLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT 1380

Query: 1777 DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGR 1836
            DARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGR
Sbjct: 1381 DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1440

Query: 1837 TGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY 1896
            TGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHY
Sbjct: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY 1500

Query: 1897 AT 1898
            AT
Sbjct: 1501 AT 1502



 Score =  805 bits (2080), Expect = 0.0
 Identities = 404/623 (64%), Positives = 496/623 (79%), Gaps = 14/623 (2%)

Query: 18  LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
           L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 9   LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68

Query: 78  FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
           FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 69  FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128

Query: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSG------A 191
           DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSG      A
Sbjct: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGA 188

Query: 192 LQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVMPGG 247
           LQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+MPGG
Sbjct: 189 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248

Query: 248 SVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMI 307
           SVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+I
Sbjct: 249 SVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVI 308

Query: 308 EATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVD 367
           EA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++E+D
Sbjct: 309 EAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEID 368

Query: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSA 427
           GVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARMLS+
Sbjct: 369 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 428

Query: 428 STMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLR 487
           +T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TYS++
Sbjct: 429 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVK 488

Query: 488 VLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVY 547
           VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YELVY
Sbjct: 489 VLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVY 548

Query: 548 WAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPS 607
              E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS  +
Sbjct: 549 KDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA 607

Query: 608 APPQKVMCVSMGSTTVRVSWVPP 630
              +     ++  T+V +SW  P
Sbjct: 608 ---KNFHVKAVMKTSVLLSWEIP 627



 Score =  147 bits (371), Expect = 1e-34
 Identities = 121/425 (28%), Positives = 196/425 (46%), Gaps = 34/425 (8%)

Query: 580  FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
            +   A S +GV      I   T ++ P  P   V+  S  +T++ ++W     DS N   
Sbjct: 297  YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 347

Query: 640  TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
              Y +        +     +DG++   + + + GL  +++Y   V A  ++G GP S PV
Sbjct: 348  VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405

Query: 700  LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
            L +T E  PS  PR V+   L+ST + V WK   P + +GQI+GY+V Y        + +
Sbjct: 406  LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYTM---DPTQHV 460

Query: 760  PIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMI 819
                   +A++Q TTI  L P+ TYSV V A+T+ GDG  S    V T   VPG+P    
Sbjct: 461  NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 520

Query: 820  STTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTT 878
            +     T+ LL W PP+     +  Y L Y   +      I   +    + + GL   + 
Sbjct: 521  AEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSYRLQGLKPNSL 577

Query: 879  YIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG 937
            Y FRLAA++  GLG    E   RT   + S F +N HV  +  ++  L+W+ P   E   
Sbjct: 578  YYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSWEIP---ENYN 631

Query: 938  RIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG--SGPLSPSIQ 995
              + + +++ D    +E+    T     +  LKP+ +Y   +   T++G  +G L   + 
Sbjct: 632  SAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGNSAGGLQHRVT 686

Query: 996  SRTMP 1000
            ++T P
Sbjct: 687  AKTAP 691


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 1405 bits (3638), Expect = 0.0
 Identities = 732/1141 (64%), Positives = 858/1141 (75%), Gaps = 30/1141 (2%)

Query: 774  TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 831
            +I GL+P + Y + V+A  + G G  S+  +  T    P      +    ++  T ++QW
Sbjct: 379  SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438

Query: 832  HPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIFRLAAKNRA 889
              P E  G + GYR+ Y    E    N      DD   T  G L +  TY  R+ A    
Sbjct: 439  EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498

Query: 890  GLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
            G G   +  +++T + +P G P NL     + ++  L+W PP    R   II Y ++FR+
Sbjct: 499  GDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESIIKYELLFRE 553

Query: 949  INSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK 1007
             +  +E+ +     T + +  LKP+T Y  ++ A + +G G  +P ++ RT+  + +  K
Sbjct: 554  GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL--QSISPK 611

Query: 1008 NFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFV 1067
            NF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+P+T Y+FV
Sbjct: 612  NFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFV 671

Query: 1068 LMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVV 1127
            L NRGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  V+ ++IV+
Sbjct: 672  LTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVM 731

Query: 1128 VPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLP 1186
            VP+ +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+AA+  VLP
Sbjct: 732  VPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLP 790

Query: 1187 ETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ 1246
             TF  GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   +     Q 
Sbjct: 791  PTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLDNPDPQP 848

Query: 1247 QEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA----- 1299
              + E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      LL      
Sbjct: 849  IVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLLNNADLA 904

Query: 1300 --HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFT 1357
              H  DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYESIDPGQQFT
Sbjct: 905  PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT 964

Query: 1358 WENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGP 1417
            WE+SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QNAYIATQGP
Sbjct: 965  WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP 1024

Query: 1418 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1477
            LPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLLDT+ELA
Sbjct: 1025 LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA 1084

Query: 1478 TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVV 1537
            T+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VV
Sbjct: 1085 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1144

Query: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
            HCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLE
Sbjct: 1145 HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1204

Query: 1598 AATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKF 1657
            A  CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISANLPCNKF
Sbjct: 1205 AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF 1264

Query: 1658 KNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRM 1717
            KNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRM
Sbjct: 1265 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1324

Query: 1718 LWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1777
            LWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD
Sbjct: 1325 LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1384

Query: 1778 ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRT 1837
            ARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRT
Sbjct: 1385 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1444

Query: 1838 GVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
            GVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYA
Sbjct: 1445 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1504

Query: 1898 T 1898
            T
Sbjct: 1505 T 1505



 Score =  838 bits (2165), Expect = 0.0
 Identities = 440/715 (61%), Positives = 528/715 (73%), Gaps = 27/715 (3%)

Query: 1   MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
           MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
           KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
           KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSI 236
           NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR    VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240

Query: 237 PPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANY 296
            P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANY
Sbjct: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300

Query: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
           TCVA+SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360

Query: 357 AGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP 416
              +GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S 
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420

Query: 417 PRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVG 476
           PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVG
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480

Query: 477 SLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP 536
           SLL   TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P 
Sbjct: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540

Query: 537 QERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596
           QE II YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP 
Sbjct: 541 QESIIKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599

Query: 597 IEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR 656
           +  RT Q   S  P+      +  T+V +SW  P  D+ N   T Y + Y  +  +  GR
Sbjct: 600 VRQRTLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGR 653

Query: 657 HVVDGIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
                I+  + H+ ++ V         GL++    WT + + +     V P P++
Sbjct: 654 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 707



 Score =  137 bits (346), Expect = 8e-32
 Identities = 122/421 (28%), Positives = 190/421 (45%), Gaps = 36/421 (8%)

Query: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
           L D+K    Y     A S +GV      I  ++    P  P    M     +T++ ++W 
Sbjct: 291 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 343

Query: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
               DS N     Y V       +D    + + I+   + + + GL   +EY +WV A  
Sbjct: 344 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 397

Query: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
            +G GP S  V+ RT E  P+  PR V+   L++T + V W+ PV  + +G IRGY+V Y
Sbjct: 398 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 454

Query: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
             +E   P G    Q   + ++  TT+  L  + TY+V V A+T+ GDG  S P  V T 
Sbjct: 455 YTMEPEHPVG--NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 512

Query: 809 GAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH 867
             VPG+P  + +     T++ L W PP++    ++ Y L +   D  R     F      
Sbjct: 513 QGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREVGRTFDPTTS- 569

Query: 868 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
           + V  L   T Y FRLAA++  GLG  F   +R    L S  P+N  V  +  ++  L+W
Sbjct: 570 YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKMIMKTSVLLSW 627

Query: 928 D-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
           + P          I Y  +  D++ +         T+  +T LKP T Y+  +   T++G
Sbjct: 628 EFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYNFVL---TNRG 676

Query: 987 S 987
           S
Sbjct: 677 S 677



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)

Query: 901  TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 957
            T + LP   P    VT  T ++  + WD       N   +SY V+     SQ    +++ 
Sbjct: 318  TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 371

Query: 958  ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1016
              T TR+++ GL P++ Y+I V A  S G GP S S+ +RT       A +N +      
Sbjct: 372  DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 431

Query: 1017 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1066
            T++++ WE P            Y +  P   + N Q   VD   +  + + L+  T    
Sbjct: 432  TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 491

Query: 1067 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1096
            VL       G L   + ++T    +P +P+
Sbjct: 492  VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 520


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 1405 bits (3638), Expect = 0.0
 Identities = 732/1141 (64%), Positives = 858/1141 (75%), Gaps = 30/1141 (2%)

Query: 774  TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 831
            +I GL+P + Y + V+A  + G G  S+  +  T    P      +    ++  T ++QW
Sbjct: 375  SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 434

Query: 832  HPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIFRLAAKNRA 889
              P E  G + GYR+ Y    E    N      DD   T  G L +  TY  R+ A    
Sbjct: 435  EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 494

Query: 890  GLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
            G G   +  +++T + +P G P NL     + ++  L+W PP    R   II Y ++FR+
Sbjct: 495  GDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESIIKYELLFRE 549

Query: 949  INSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK 1007
             +  +E+ +     T + +  LKP+T Y  ++ A + +G G  +P ++ RT+  + +  K
Sbjct: 550  GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL--QSISPK 607

Query: 1008 NFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFV 1067
            NF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+P+T Y+FV
Sbjct: 608  NFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFV 667

Query: 1068 LMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVV 1127
            L NRGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  V+ ++IV+
Sbjct: 668  LTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVM 727

Query: 1128 VPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLP 1186
            VP+ +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+AA+  VLP
Sbjct: 728  VPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLP 786

Query: 1187 ETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ 1246
             TF  GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   +     Q 
Sbjct: 787  PTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLDNPDPQP 844

Query: 1247 QEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA----- 1299
              + E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      LL      
Sbjct: 845  IVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLLNNADLA 900

Query: 1300 --HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFT 1357
              H  DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYESIDPGQQFT
Sbjct: 901  PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT 960

Query: 1358 WENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGP 1417
            WE+SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QNAYIATQGP
Sbjct: 961  WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP 1020

Query: 1418 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1477
            LPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLLDT+ELA
Sbjct: 1021 LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA 1080

Query: 1478 TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVV 1537
            T+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VV
Sbjct: 1081 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1140

Query: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
            HCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLE
Sbjct: 1141 HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1200

Query: 1598 AATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKF 1657
            A  CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISANLPCNKF
Sbjct: 1201 AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF 1260

Query: 1658 KNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRM 1717
            KNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRM
Sbjct: 1261 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1320

Query: 1718 LWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1777
            LWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD
Sbjct: 1321 LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1380

Query: 1778 ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRT 1837
            ARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRT
Sbjct: 1381 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1440

Query: 1838 GVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
            GVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYA
Sbjct: 1441 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1500

Query: 1898 T 1898
            T
Sbjct: 1501 T 1501



 Score =  844 bits (2180), Expect = 0.0
 Identities = 440/711 (61%), Positives = 528/711 (74%), Gaps = 23/711 (3%)

Query: 1   MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
           MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
           KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
           KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
           NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240

Query: 241 QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
            E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANYTCVA
Sbjct: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300

Query: 301 ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
           +SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++   +
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360

Query: 361 GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
           GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S PR V
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420

Query: 421 QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
           QARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVGSLL 
Sbjct: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 481 GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
             TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P QE I
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540

Query: 541 IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
           I YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP +  R
Sbjct: 541 IKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599

Query: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
           T Q   S  P+      +  T+V +SW  P  D+ N   T Y + Y  +  +  GR    
Sbjct: 600 TLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGRTTKK 653

Query: 661 GIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
            I+  + H+ ++ V         GL++    WT + + +     V P P++
Sbjct: 654 LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 703



 Score =  137 bits (346), Expect = 8e-32
 Identities = 122/421 (28%), Positives = 190/421 (45%), Gaps = 36/421 (8%)

Query: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
           L D+K    Y     A S +GV      I  ++    P  P    M     +T++ ++W 
Sbjct: 287 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 339

Query: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
               DS N     Y V       +D    + + I+   + + + GL   +EY +WV A  
Sbjct: 340 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 393

Query: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
            +G GP S  V+ RT E  P+  PR V+   L++T + V W+ PV  + +G IRGY+V Y
Sbjct: 394 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 450

Query: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
             +E   P G    Q   + ++  TT+  L  + TY+V V A+T+ GDG  S P  V T 
Sbjct: 451 YTMEPEHPVG--NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 508

Query: 809 GAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH 867
             VPG+P  + +     T++ L W PP++    ++ Y L +   D  R     F      
Sbjct: 509 QGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREVGRTFDPTTS- 565

Query: 868 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
           + V  L   T Y FRLAA++  GLG  F   +R    L S  P+N  V  +  ++  L+W
Sbjct: 566 YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKMIMKTSVLLSW 623

Query: 928 D-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
           + P          I Y  +  D++ +         T+  +T LKP T Y+  +   T++G
Sbjct: 624 EFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYNFVL---TNRG 672

Query: 987 S 987
           S
Sbjct: 673 S 673



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)

Query: 901  TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 957
            T + LP   P    VT  T ++  + WD       N   +SY V+     SQ    +++ 
Sbjct: 314  TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 367

Query: 958  ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1016
              T TR+++ GL P++ Y+I V A  S G GP S S+ +RT       A +N +      
Sbjct: 368  DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 427

Query: 1017 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1066
            T++++ WE P            Y +  P   + N Q   VD   +  + + L+  T    
Sbjct: 428  TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 487

Query: 1067 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1096
            VL       G L   + ++T    +P +P+
Sbjct: 488  VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 516


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 1260 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 153  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 207

Query: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1377
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 208  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 267

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 268  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 327

Query: 1438 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1496
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 328  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387

Query: 1497 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1553
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 388  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 447

Query: 1554 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1613
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 448  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 507

Query: 1614 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1673
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 508  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1674 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1733
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1734 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1793
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 687

Query: 1794 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1853
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 688  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 746

Query: 1854 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 747  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 1260 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 162  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 216

Query: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1377
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 217  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 276

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 277  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 336

Query: 1438 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1496
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 337  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 396

Query: 1497 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1553
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 397  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 456

Query: 1554 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1613
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 457  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 516

Query: 1614 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1673
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 517  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 576

Query: 1674 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1733
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 577  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 636

Query: 1734 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1793
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 637  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 696

Query: 1794 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1853
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 697  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 755

Query: 1854 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 756  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 799


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 1260 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 153  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 207

Query: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1377
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 208  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 267

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 268  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 327

Query: 1438 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1496
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 328  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387

Query: 1497 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1553
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 388  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 447

Query: 1554 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1613
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 448  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 507

Query: 1614 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1673
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 508  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1674 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1733
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1734 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1793
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 687

Query: 1794 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1853
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 688  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 746

Query: 1854 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 747  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  566 bits (1459), Expect = e-161
 Identities = 294/664 (44%), Positives = 418/664 (62%), Gaps = 14/664 (2%)

Query: 1243 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSS 1302
            P     +P + W+  P+L ++L++L+      F+++R    S+ D++   + + +L    
Sbjct: 39   PDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKK---MPNGIL-EEQ 94

Query: 1303 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENS 1361
            +   +  L+    G + + PIP+  L + I    A+D  +F +E+ S+  G  Q T+E +
Sbjct: 95   EQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELA 154

Query: 1362 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1421
            N E N+ KNRY N++  DHSRVIL+ +DG+P SDYINA+YIDGY+++N +IA QGP  ET
Sbjct: 155  NKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQET 214

Query: 1422 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1481
            + DFWRMVWEQ++AT+VM+T L+E+   KC QYWP +G  T G I+V + D V L  YT+
Sbjct: 215  VNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTI 274

Query: 1482 RTFALHKS---GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1538
            R F +      G    R + Q  F +WPD GVP  P  +L FL++VK  NP+ AGP+VVH
Sbjct: 275  RKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVH 334

Query: 1539 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1598
            CSAGVGRTG FIVIDAM+  M  E+ VD++  V+ +R+QR  MVQT+ QY FI++ALLE 
Sbjct: 335  CSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394

Query: 1599 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFK 1658
               G TE+   +L  H+Q +           +E EF+ L + +       + NLP N  K
Sbjct: 395  YLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKK 454

Query: 1659 NRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRML 1718
             R++ I+PY+  RV L   RG E +DYINASF+DGYRQ+  +IATQGPLA + EDFWRM+
Sbjct: 455  ARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMI 514

Query: 1719 WEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-- 1776
            WE  S  IVMLT+++E  ++KC+QYWP E S  +    ++   +       +R+F VT  
Sbjct: 515  WEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLN 574

Query: 1777 ---DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAG 1833
                 ++ Q R +RQF F  WPE G+P  G+G ID I  V K ++Q G + PITVHCSAG
Sbjct: 575  QPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAG 633

Query: 1834 VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF 1893
             GRTG FI LS +LER++ EG++D+FQ VK+LR QRP MVQT +QY+ CY+   +++  F
Sbjct: 634  AGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIF 693

Query: 1894 DHYA 1897
              YA
Sbjct: 694  SDYA 697


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  551 bits (1420), Expect = e-156
 Identities = 287/632 (45%), Positives = 402/632 (63%), Gaps = 14/632 (2%)

Query: 1275 FKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIER 1334
            F+++R    S+ D++   + + +L    +   +  L+    G + + PIP+  L + I  
Sbjct: 13   FRKQRKAVVSTSDKK---MPNGIL-EEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRI 68

Query: 1335 LKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG 1393
              A+D  +F +E+ S+  G  Q T+E +N E N+ KNRY N++  DHSRVIL+ +DG+P 
Sbjct: 69   RSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPC 128

Query: 1394 SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ 1453
            SDYINA+YIDGY+++N +IA QGP  ET+ DFWRMVWEQ++AT+VM+T L+E+   KC Q
Sbjct: 129  SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQ 188

Query: 1454 YWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS---GSSEKRELRQFQFMAWPDHGV 1510
            YWP +G  T G I+V + D V L  YT+R F +      G    R + Q  F +WPD GV
Sbjct: 189  YWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGV 248

Query: 1511 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1570
            P  P  +L FL++VK  NP+ AGP+VVHCSAGVGRTG FIVIDAM+  M  E+ VD++  
Sbjct: 249  PFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEF 308

Query: 1571 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1630
            V+ +R+QR  MVQT+ QY FI++ALLE    G TE+   +L  H+Q +           +
Sbjct: 309  VSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGL 368

Query: 1631 ELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1690
            E EF+ L + +       + NLP N  K R++ I+PY+  RV L   RG E +DYINASF
Sbjct: 369  EEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 428

Query: 1691 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1750
            +DGYRQ+  +IATQGPLA + EDFWRM+WE  S  IVMLT+++E  ++KC+QYWP E S 
Sbjct: 429  IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV 488

Query: 1751 RYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTIRQFQFTDWPEQGVPKTGEG 1805
             +    ++   +       +R+F VT       ++ Q R +RQF F  WPE G+P  G+G
Sbjct: 489  THGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKG 548

Query: 1806 FIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTL 1865
             ID I  V K ++Q G + PITVHCSAG GRTG FI LS +LER++ EG++D+FQ VK+L
Sbjct: 549  MIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607

Query: 1866 RTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
            R QRP MVQT +QY+ CY+   +++  F  YA
Sbjct: 608  RLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  510 bits (1313), Expect = e-144
 Identities = 351/1090 (32%), Positives = 542/1090 (49%), Gaps = 144/1090 (13%)

Query: 910  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 966
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449

Query: 967  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1018
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501

Query: 1019 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1063
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561

Query: 1064 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1119
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619

Query: 1120 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1175
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669

Query: 1176 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYASS 1231
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725

Query: 1232 PYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLF---------------- 1275
              S +    V P +Q +    +   G +  +++ I+I++ ++L                 
Sbjct: 726  GASTQNSNTVEPEKQVDNTVKM--AGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKL 783

Query: 1276 --KRKRTHSPSSKDEQSIGLKD-------------------------------------- 1295
              K+K T S + ++   +   D                                      
Sbjct: 784  AKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTL 843

Query: 1296 SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDP 1352
            ++  H   + DPVEM       P  +  P I + DL  +I ++K   G  F +EYE++  
Sbjct: 844  TIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE 898

Query: 1353 GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYI 1412
            GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SDYINANYIDGY +   YI
Sbjct: 899  GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYI 958

Query: 1413 ATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLD 1472
            ATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YWP   TE  G I+VTL++
Sbjct: 959  ATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIE 1017

Query: 1473 TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA 1532
            T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T +L F+R+VK  NP +A
Sbjct: 1018 TEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEA 1077

Query: 1533 GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIH 1592
            GP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R+QR  +VQTE+QYVF+H
Sbjct: 1078 GPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVH 1137

Query: 1593 EALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRF 1647
            +A+LEA  CG+T +P    R+LY +I +L    P  + + ++ EF+ L   + +      
Sbjct: 1138 DAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKDEFQTLNIVTPRVRPEDC 1194

Query: 1648 ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPL 1707
                LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL
Sbjct: 1195 SIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPL 1253

Query: 1708 AESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ 1767
              +  DFWR+++++N + +VML ++     + C QYWP + S  Y    V+ ++      
Sbjct: 1254 PNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDED 1311

Query: 1768 YILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQF-GQD 1823
             I R F++ +    Q   R ++  Q+  WP  +  P +    +  + ++ K +EQ+ G++
Sbjct: 1312 IIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGRE 1371

Query: 1824 GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883
            G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR  +  MV+T +QY+  Y
Sbjct: 1372 GRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVY 1431

Query: 1884 RAALEYLGSF 1893
              ALEYL SF
Sbjct: 1432 EVALEYLSSF 1441



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262

Query: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306

Query: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360

Query: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479

Query: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539

Query: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594

Query: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319

Query: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377

Query: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437

Query: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494

Query: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553

Query: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609

Query: 628 VPPPADSRNGVITQYSV 644
           +  PA SR   ++ Y +
Sbjct: 610 MLKPAQSRGAPVSVYQL 626



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 42/254 (16%)

Query: 778  LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWH 832
            L P+  Y + V   T  G+G    P    TT       V G   + I         LQW 
Sbjct: 350  LDPDVEYEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWE 408

Query: 833  PPKELPGELLGYRLQYCRA-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIF 881
            P         GY +  C +           ++ +    +  +   H+T+ GL    T   
Sbjct: 409  P--------FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRL 460

Query: 882  RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS 941
            RL   N  G  E  E  ++T ED+P   P      G       + W PP   E NG I  
Sbjct: 461  RLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITL 518

Query: 942  YTVVFR---------DINSQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-- 989
            Y + ++         D++SQ+ ++  +  +T     GL P TTY   ++A T+KG GP  
Sbjct: 519  YEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPV 578

Query: 990  ---LSPSIQSRTMP 1000
               ++  I + +MP
Sbjct: 579  TTRIATKISAPSMP 592



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 72/282 (25%), Positives = 118/282 (41%), Gaps = 15/282 (5%)

Query: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597
           II+ E+ Y        +  +   P  +Y L  L PD  Y  R  L    + G G   P +
Sbjct: 320 IILKEVEYRTTTGTWAETHIVDSP--NYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377

Query: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657
             RT  + P   PQ V  V + +  + + W P             +V Y+ V  + +  +
Sbjct: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQ--Y 435

Query: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP-RKVE 716
             + + +  S + L GL  +   R+ +      G   ES  ++V+T+EDVP   P   ++
Sbjct: 436 EAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELVVQTEEDVPGAVPLESIQ 494

Query: 717 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETT-- 774
             P     +++ WK   P++ +G I  Y++ Y  + + +P      Q   + + +  T  
Sbjct: 495 GGPFEEK-IYIQWK--PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHH 551

Query: 775 -ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 815
              GL P TTYS T+ A T KG G     +I T   A P  P
Sbjct: 552 LFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA-PSMP 592



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 10/122 (8%)

Query: 936  NGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWT--SKGSGPLSPS 993
            +G II   V +R         +I     + L  L PD  Y+I+V        G+GP  P 
Sbjct: 317  DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376

Query: 994  IQSRTMPVEQVFA-KNFRVAAAMKTSVLLSWEV-------PDSYKSAVPFKILYNGQSVE 1045
            + +RT   + V   +N  +       + L WE          SY   V ++ ++N Q  E
Sbjct: 377  LTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYE 436

Query: 1046 VD 1047
             +
Sbjct: 437  AE 438


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  506 bits (1303), Expect = e-143
 Identities = 300/778 (38%), Positives = 443/778 (56%), Gaps = 69/778 (8%)

Query: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1229
            Y AA+L    LPE   FT+GD + Y+GF+N PL+P   Y  +  A      + K      
Sbjct: 669  YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728

Query: 1230 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1282
               +  ++E  V   PA+Q +   ++  ++  +L  IL++L+VI I+    L K+++   
Sbjct: 729  ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788

Query: 1283 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1311
             +++ E +  +        D    H+ DP+ +  ++                        
Sbjct: 789  GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848

Query: 1312 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1361
                      YQT  +  HP I + DL  +I  +K +D   F +EYES   GQ  +W+ +
Sbjct: 849  RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906

Query: 1362 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1421
              + N+ KNRY N+IAYDHSRVIL  ++  P SDYINANYIDGY++ + YIATQGP+ ET
Sbjct: 907  KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHET 966

Query: 1422 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1481
            + DFWRM+W++++A +VM+T L E  RVKC +YWP   TE  G  +VT ++   LA Y V
Sbjct: 967  VYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVV 1025

Query: 1482 RTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA 1541
            RTF L + G +E RE++QF F  WPDHGVP + T +L+F+RRVK  NP  AGP+VVHCSA
Sbjct: 1026 RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSA 1085

Query: 1542 GVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC 1601
            G GRTGC+IVID ML+  + E  VDIY  V  +RS+R  MVQTE+QY+FIH+A+LEA  C
Sbjct: 1086 GAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC 1145

Query: 1602 GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLPCNKFKN 1659
            G T +P     A    + ++    + + ++ EF+ L S   +        A LP N  KN
Sbjct: 1146 GETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN 1205

Query: 1660 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1719
            R ++++P +     L  I G E S+YINA+ +D YRQ  A+I TQ PL  + +DFWR+++
Sbjct: 1206 RFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVY 1264

Query: 1720 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVT 1776
            ++  T IVML ++     + C QYWP E   RY    V+ M+   + ++   I R   +T
Sbjct: 1265 DYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLT 1322

Query: 1777 DARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITVHCSAGV 1834
              ++G    ++QFQ+  W   + VP +   F+  I QV K +E+  + +G   +HC  G 
Sbjct: 1323 RPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGG 1381

Query: 1835 GRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS 1892
            GR+G+F  + IV+E ++ + VVD+F  VKTLR  +P MV+  +QY+ CY  ALEYL S
Sbjct: 1382 GRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
           EV  G +    C+A G    + K W+    +    +++PV   +N+          L  V
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260

Query: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
            ++    Y CV  S  G  +   AQ+ V+  P+P  P  L+    T   + L  +S   +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
            P+    ++YR   T G + E   V    Y +  L P +EY  RVL       G G P  
Sbjct: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
            +  RT    P   P+ ++   + A  + V WE          GY +   +T +     +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
            +  HN + A  L          V  L P    SL+++     G      TI ++T + V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489

Query: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
           P   P         + +I L+W  P  P   I  YE+ Y +    D    V   P     
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
              ++ +    L P T Y+F + A +  G G  T  I   T  S P+ P  + +  S+  
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608

Query: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
           T   ++ +  PA ++   I+ Y +  E
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)

Query: 778  LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 832
            L P+T Y + V   T  G+G       P I  T  A P R   T+ I+        + W 
Sbjct: 353  LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410

Query: 833  PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 879
                   E LGY +  C               +E++ + +D         V  L   T  
Sbjct: 411  -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463

Query: 880  IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 938
              ++   N  G  E  E  I+T ED+P   P ++L  T        L W  P+  + NG 
Sbjct: 464  SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520

Query: 939  IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988
            I  Y + +  I S           Q + N+   T      L P TTY   +RA T KG G
Sbjct: 521  ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580

Query: 989  P-----LSPSIQSRTMP 1000
            P     ++ +I + T+P
Sbjct: 581  PATAINVTTNISAPTLP 597



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 92/426 (21%), Positives = 153/426 (35%), Gaps = 40/426 (9%)

Query: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597
           II+ E+ Y        +      PT  Y L  L PDT Y  R  L    + G G+  P +
Sbjct: 323 IILKEVEYRMTSGSWTETHAVNAPT--YKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPL 380

Query: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657
             RT  + P   P+ +    + +  + V W     +         ++ Y    G +  + 
Sbjct: 381 ITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKA 440

Query: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEV 717
               +  +     +  L  +T   + +      G   ES   +++TDEDVP   P K   
Sbjct: 441 DCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQ 499

Query: 718 EPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPII---QDVM-LAEAQET 773
                  + + WK P+    +G I  Y+++Y  + + +P  +P+    Q V  L  +   
Sbjct: 500 GTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDP-AVPVAGPPQTVSNLWNSTHH 556

Query: 774 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTAL 828
               L P TTY   + A T KG G  +   + T   A       G    +  T    T L
Sbjct: 557 VFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVL 616

Query: 829 LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 888
           L+  P +     +  Y++     +E  P          H T         Y   +  +N 
Sbjct: 617 LR--PAQAKGAPISAYQIV---VEELHP----------HRTKREAGAMECYQVPVTYQNA 661

Query: 889 AGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
              G  +      P   P   P+    T     T +  W+PP LA R G    Y + F+ 
Sbjct: 662 MSGGAPYYFAAELP---PGNLPEPAPFTVGDNRTYQGFWNPP-LAPRKG----YNIYFQA 713

Query: 949 INSQQE 954
           ++S ++
Sbjct: 714 MSSVEK 719



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)

Query: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
           P   Y +RVL  T  G+G    P P +  +T+   P + P   +       RI + W  L
Sbjct: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413

Query: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
                R   + +     Y+   +E +   +  DP +  + +  L P T    ++   +  
Sbjct: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473

Query: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
           G      TI  +T +  P   P K +  +     + ++W  P     NG+ITQY ++Y +
Sbjct: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530

Query: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
           +   D    V        + W+      + L   T Y+ ++RA T  G GP ++ + V T
Sbjct: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589

Query: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
           +   P+ P  +     LN TA  +   L     +   I  YQ+    L
Sbjct: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  504 bits (1298), Expect = e-142
 Identities = 356/1107 (32%), Positives = 546/1107 (49%), Gaps = 159/1107 (14%)

Query: 910  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 966
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449

Query: 967  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1018
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501

Query: 1019 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1063
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561

Query: 1064 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1119
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619

Query: 1120 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1175
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669

Query: 1176 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYAS- 1230
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725

Query: 1231 SPYSDEIVVQVTP-------AQQQE----EPEM-----LWVTGPVLAVILIILIVIAILL 1274
            +P     V   TP       A  Q     EPE      + + G +  +++ I+I++ ++L
Sbjct: 726  APMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML 785

Query: 1275 F------------------KRKRTHSPSSKDEQSIGLKD--------------------- 1295
                               K+K T S + ++   +   D                     
Sbjct: 786  TIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQD 845

Query: 1296 -----------------SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERL 1335
                             ++  H   + DPVEM       P  +  P I + DL  +I ++
Sbjct: 846  VNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQM 900

Query: 1336 KANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSD 1395
            K   G  F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SD
Sbjct: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960

Query: 1396 YINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW 1455
            YINANYIDGY +   YIATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YW
Sbjct: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020

Query: 1456 PARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPT 1515
            P   TE  G I+VTL++T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T
Sbjct: 1021 PD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYAT 1079

Query: 1516 PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMR 1575
             +L F+R+VK  NP +AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R
Sbjct: 1080 GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1139

Query: 1576 SQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMEL 1632
            +QR  +VQTE+QYVF+H+A+LEA  CG+T +P    R+LY +I +L    P  + + ++ 
Sbjct: 1140 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKD 1196

Query: 1633 EFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1690
            EF+ L   + +          LP N  KNR ++++P +     L  + G E S+YINA+ 
Sbjct: 1197 EFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAAL 1255

Query: 1691 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1750
            +D ++Q  A++ TQ PL  +  DFWR+++++N + +VML ++     + C QYWP + S 
Sbjct: 1256 MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSG 1313

Query: 1751 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFI 1807
             Y    V+ ++       I R F++ +    Q   R ++  Q+  WP  +  P +    +
Sbjct: 1314 CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLL 1373

Query: 1808 DFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLR 1866
              + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR
Sbjct: 1374 KVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLR 1433

Query: 1867 TQRPAMVQTEDQYQLCYRAALEYLGSF 1893
              +  MV+T +QY+  Y  ALEYL SF
Sbjct: 1434 NNKSNMVETLEQYKFVYEVALEYLSSF 1460



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262

Query: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306

Query: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360

Query: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479

Query: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539

Query: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594

Query: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319

Query: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377

Query: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437

Query: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494

Query: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553

Query: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609

Query: 628 VPPPADSRNGVITQYSV 644
           +  PA SR   ++ Y +
Sbjct: 610 MLKPAQSRGAPVSVYQL 626



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 42/254 (16%)

Query: 778  LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWH 832
            L P+  Y + V   T  G+G    P    TT       V G   + I         LQW 
Sbjct: 350  LDPDVEYEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWE 408

Query: 833  PPKELPGELLGYRLQYCRA-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIF 881
            P         GY +  C +           ++ +    +  +   H+T+ GL    T   
Sbjct: 409  P--------FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRL 460

Query: 882  RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS 941
            RL   N  G  E  E  ++T ED+P   P      G       + W PP   E NG I  
Sbjct: 461  RLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITL 518

Query: 942  YTVVFR---------DINSQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-- 989
            Y + ++         D++SQ+ ++  +  +T     GL P TTY   ++A T+KG GP  
Sbjct: 519  YEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPV 578

Query: 990  ---LSPSIQSRTMP 1000
               ++  I + +MP
Sbjct: 579  TTRIATKISAPSMP 592



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 72/282 (25%), Positives = 118/282 (41%), Gaps = 15/282 (5%)

Query: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597
           II+ E+ Y        +  +   P  +Y L  L PD  Y  R  L    + G G   P +
Sbjct: 320 IILKEVEYRTTTGTWAETHIVDSP--NYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377

Query: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657
             RT  + P   PQ V  V + +  + + W P             +V Y+ V  + +  +
Sbjct: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQ--Y 435

Query: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP-RKVE 716
             + + +  S + L GL  +   R+ +      G   ES  ++V+T+EDVP   P   ++
Sbjct: 436 EAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELVVQTEEDVPGAVPLESIQ 494

Query: 717 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETT-- 774
             P     +++ WK   P++ +G I  Y++ Y  + + +P      Q   + + +  T  
Sbjct: 495 GGPFEEK-IYIQWK--PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHH 551

Query: 775 -ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 815
              GL P TTYS T+ A T KG G     +I T   A P  P
Sbjct: 552 LFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA-PSMP 592



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 10/122 (8%)

Query: 936  NGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWT--SKGSGPLSPS 993
            +G II   V +R         +I     + L  L PD  Y+I+V        G+GP  P 
Sbjct: 317  DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376

Query: 994  IQSRTMPVEQVFA-KNFRVAAAMKTSVLLSWEV-------PDSYKSAVPFKILYNGQSVE 1045
            + +RT   + V   +N  +       + L WE          SY   V ++ ++N Q  E
Sbjct: 377  LTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYE 436

Query: 1046 VD 1047
             +
Sbjct: 437  AE 438


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  499 bits (1286), Expect = e-141
 Identities = 300/784 (38%), Positives = 443/784 (56%), Gaps = 75/784 (9%)

Query: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1229
            Y AA+L    LPE   FT+GD + Y+GF+N PL+P   Y  +  A      + K      
Sbjct: 669  YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728

Query: 1230 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1282
               +  ++E  V   PA+Q +   ++  ++  +L  IL++L+VI I+    L K+++   
Sbjct: 729  ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788

Query: 1283 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1311
             +++ E +  +        D    H+ DP+ +  ++                        
Sbjct: 789  GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848

Query: 1312 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1361
                      YQT  +  HP I + DL  +I  +K +D   F +EYES   GQ  +W+ +
Sbjct: 849  RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906

Query: 1362 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIATQ 1415
              + N+ KNRY N+IAYDHSRVIL  ++  P SDYINANYID      GY++ + YIATQ
Sbjct: 907  KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQ 966

Query: 1416 GPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVE 1475
            GP+ ET+ DFWRM+W++++A +VM+T L E  RVKC +YWP   TE  G  +VT ++   
Sbjct: 967  GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEP 1025

Query: 1476 LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPM 1535
            LA Y VRTF L + G +E RE++QF F  WPDHGVP + T +L+F+RRVK  NP  AGP+
Sbjct: 1026 LAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPI 1085

Query: 1536 VVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
            VVHCSAG GRTGC+IVID ML+  + E  VDIY  V  +RS+R  MVQTE+QY+FIH+A+
Sbjct: 1086 VVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI 1145

Query: 1596 LEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLP 1653
            LEA  CG T +P     A    + ++    + + ++ EF+ L S   +        A LP
Sbjct: 1146 LEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLP 1205

Query: 1654 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1713
             N  KNR ++++P +     L  I G E S+YINA+ +D YRQ  A+I TQ PL  + +D
Sbjct: 1206 RNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKD 1264

Query: 1714 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYIL 1770
            FWR+++++  T IVML ++     + C QYWP E   RY    V+ M+   + ++   I 
Sbjct: 1265 FWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIF 1322

Query: 1771 REFKVTDARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITV 1828
            R   +T  ++G    ++QFQ+  W   + VP +   F+  I QV K +E+  + +G   +
Sbjct: 1323 RICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTII 1381

Query: 1829 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1888
            HC  G GR+G+F  + IV+E ++ + VVD+F  VKTLR  +P MV+  +QY+ CY  ALE
Sbjct: 1382 HCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441

Query: 1889 YLGS 1892
            YL S
Sbjct: 1442 YLES 1445



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
           EV  G +    C+A G    + K W+    +    +++PV   +N+          L  V
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260

Query: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
            ++    Y CV  S  G  +   AQ+ V+  P+P  P  L+    T   + L  +S   +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
            P+    ++YR   T G + E   V    Y +  L P +EY  RVL       G G P  
Sbjct: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
            +  RT    P   P+ ++   + A  + V WE          GY +   +T +     +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
            +  HN + A  L          V  L P    SL+++     G      TI ++T + V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489

Query: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
           P   P         + +I L+W  P  P   I  YE+ Y +    D    V   P     
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
              ++ +    L P T Y+F + A +  G G  T  I   T  S P+ P  + +  S+  
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608

Query: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
           T   ++ +  PA ++   I+ Y +  E
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)

Query: 778  LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 832
            L P+T Y + V   T  G+G       P I  T  A P R   T+ I+        + W 
Sbjct: 353  LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410

Query: 833  PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 879
                   E LGY +  C               +E++ + +D         V  L   T  
Sbjct: 411  -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463

Query: 880  IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 938
              ++   N  G  E  E  I+T ED+P   P ++L  T        L W  P+  + NG 
Sbjct: 464  SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520

Query: 939  IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988
            I  Y + +  I S           Q + N+   T      L P TTY   +RA T KG G
Sbjct: 521  ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580

Query: 989  P-----LSPSIQSRTMP 1000
            P     ++ +I + T+P
Sbjct: 581  PATAINVTTNISAPTLP 597



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 92/426 (21%), Positives = 153/426 (35%), Gaps = 40/426 (9%)

Query: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597
           II+ E+ Y        +      PT  Y L  L PDT Y  R  L    + G G+  P +
Sbjct: 323 IILKEVEYRMTSGSWTETHAVNAPT--YKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPL 380

Query: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657
             RT  + P   P+ +    + +  + V W     +         ++ Y    G +  + 
Sbjct: 381 ITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKA 440

Query: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEV 717
               +  +     +  L  +T   + +      G   ES   +++TDEDVP   P K   
Sbjct: 441 DCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQ 499

Query: 718 EPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPII---QDVM-LAEAQET 773
                  + + WK P+    +G I  Y+++Y  + + +P  +P+    Q V  L  +   
Sbjct: 500 GTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDP-AVPVAGPPQTVSNLWNSTHH 556

Query: 774 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTAL 828
               L P TTY   + A T KG G  +   + T   A       G    +  T    T L
Sbjct: 557 VFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVL 616

Query: 829 LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 888
           L+  P +     +  Y++     +E  P          H T         Y   +  +N 
Sbjct: 617 LR--PAQAKGAPISAYQIV---VEELHP----------HRTKREAGAMECYQVPVTYQNA 661

Query: 889 AGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
              G  +      P   P   P+    T     T +  W+PP LA R G    Y + F+ 
Sbjct: 662 MSGGAPYYFAAELP---PGNLPEPAPFTVGDNRTYQGFWNPP-LAPRKG----YNIYFQA 713

Query: 949 INSQQE 954
           ++S ++
Sbjct: 714 MSSVEK 719



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)

Query: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
           P   Y +RVL  T  G+G    P P +  +T+   P + P   +       RI + W  L
Sbjct: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413

Query: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
                R   + +     Y+   +E +   +  DP +  + +  L P T    ++   +  
Sbjct: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473

Query: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
           G      TI  +T +  P   P K +  +     + ++W  P     NG+ITQY ++Y +
Sbjct: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530

Query: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
           +   D    V        + W+      + L   T Y+ ++RA T  G GP ++ + V T
Sbjct: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589

Query: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
           +   P+ P  +     LN TA  +   L     +   I  YQ+    L
Sbjct: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  498 bits (1281), Expect = e-140
 Identities = 279/629 (44%), Positives = 382/629 (60%), Gaps = 20/629 (3%)

Query: 1271 AILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLAD 1330
            AIL+     TH+ +S D  S+     + +H+    E   + YQT  +  HP I + DL  
Sbjct: 849  AILVPINDETHTMAS-DTSSL-----VQSHTYKKREPADVPYQTGQL--HPAIRVADLLQ 900

Query: 1331 NIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDG 1390
            +I ++K  +G  F +EYES   GQ   W+++  + N+ KNRY N+IAYDHSRV L +I+G
Sbjct: 901  HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960

Query: 1391 VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVK 1450
               SDYIN NYIDGY + N YIATQGP+ ET+ DFWRMVW + TA+++M+T L E  RVK
Sbjct: 961  DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020

Query: 1451 CDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGV 1510
            C +YWP   TE    I+VTL++T  LA Y +RTFA+ K G  E RE+RQF F  WPDHGV
Sbjct: 1021 CCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGV 1079

Query: 1511 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1570
            P + T +L F+R+VK+ +P  AGP+VVHCSAG GRTGCFIVID ML+  + E  VDIY  
Sbjct: 1080 PYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNC 1139

Query: 1571 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1630
            V  +RS+R  MVQTE+QYVFIH+A+LEA  CG T VPA  + +    + ++ P  + + +
Sbjct: 1140 VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQI 1199

Query: 1631 ELEFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINA 1688
            + EF+ L   +          A LP N  KNR ++I+P +     L  I G E S+YINA
Sbjct: 1200 KEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINA 1258

Query: 1689 SFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--- 1745
            + +D Y+Q  A+I TQ PL  + +DFWR++ +++ T +VML  +     + C QYWP   
Sbjct: 1259 ALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENG 1316

Query: 1746 AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWP-EQGVPKTGE 1804
              R    Q   V    E ++   I R +     +DG  R ++QFQF  WP  +  P +  
Sbjct: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKR 1375

Query: 1805 GFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVK 1863
             F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R++  VD+F  VK
Sbjct: 1376 SFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVK 1435

Query: 1864 TLRTQRPAMVQTEDQYQLCYRAALEYLGS 1892
            TLR  +P MV   DQY+ CY  ALEYL S
Sbjct: 1436 TLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464



 Score =  137 bits (346), Expect = 8e-32
 Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)

Query: 1366 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1425
            N  KNR  +++  D     L +IDG   S+YINA  +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284

Query: 1426 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1485
            WR+V +    +VVM+  ++      C QYWP  G    G IQV  +          R F 
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342

Query: 1486 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1537
            ++ +   +   R ++QFQF+ WP +   + P    +FL+ ++  +          G  VV
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1400

Query: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
            HC  G GR+G F  I  + E ++H++TVD++  V  +R+ +  MV   DQY F +E  LE
Sbjct: 1401 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1460

Query: 1598 AATCG 1602
                G
Sbjct: 1461 YLNSG 1465



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295
           EV  G      C A+G  +   + W+ G +      KE ++   R  +   NVV +    
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254

Query: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345
              Y C+  +  G+ I   A++ VK   +PP+ +   +  +   T  W   N+       
Sbjct: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311

Query: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403
           P+    ++Y  A   G + +   V +T Y IG L P +EY   VL       G G P  A
Sbjct: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369

Query: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456
           +R RT    P   PR+++   + +  + ++WEP          Y   V+Y       +  
Sbjct: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429

Query: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515
           R   +W   N+      T+ +L P    S++++     G    S  + V+T + +P A P
Sbjct: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486

Query: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565
            +       + +I L W  P Q    I +YE+ Y A    D +  ++            +
Sbjct: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546

Query: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
            +    L P T Y F + A +  G G    T +  T  S PS P  ++    +  T   V
Sbjct: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604

Query: 626 SWVPPPADSRNGVITQYSVAYE 647
           + +  PA SR   ++ Y +  E
Sbjct: 605 TVMLKPAHSRGAPVSVYQIVVE 626



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 83/354 (23%), Positives = 131/354 (37%), Gaps = 45/354 (12%)

Query: 679  EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737
            +YR  +R  T+ G G  +   LV  +  VP  PP+   V      A +++ +L   S   
Sbjct: 257  KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309

Query: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG 797
             G I   +V Y           P+       ++    I  L P+T Y ++V   T  G+G
Sbjct: 310  DGPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEG 361

Query: 798  ARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRL--QYCR 850
                P     T       + G   + +         ++W P          Y L   YC 
Sbjct: 362  GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCY 421

Query: 851  ---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL 905
                 E     + +  ++ H   T+T L   T    +L   N  G  E  E  ++T EDL
Sbjct: 422  QVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDL 481

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS---QQELQN----- 957
            P   P              L W  P   +  G I  Y + ++ ++S   + +L N     
Sbjct: 482  PGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRV 539

Query: 958  --ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMPVEQV 1004
              +  +T F   GL P TTY   +RA T+KG GP      +  I + +MP  ++
Sbjct: 540  SKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYEL 593



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 961
            P   P+ L V  + +    + W+P        R  SY +       +  Q+++ + ++ D
Sbjct: 379  PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436

Query: 962  T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
            T     + T+T L P T   +K+     +G       I      +           +  +
Sbjct: 437  TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496

Query: 1017 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1061
              + L W  P  +Y     ++I Y   S    E+D           G+    L   L P 
Sbjct: 497  EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
            T YSF +  R S+A G                   PA+          SMP         
Sbjct: 557  TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590

Query: 1122 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1177
              Y +  P+++   +   ML P  S    + + +++  +E+  E  RR ++  E LK Y 
Sbjct: 591  --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644

Query: 1178 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1217
                             AA+         + FT+GD K Y G++N PL P  SY+ +  A
Sbjct: 645  VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704

Query: 1218 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1269
            + +   + K        + A++P       +  P  +++    + + G +  ++L ++I 
Sbjct: 705  ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757

Query: 1270 IAILLFKRKRTHSPSSKDEQS 1290
            + ++L  +KR  +   K+  S
Sbjct: 758  LGVVLVMKKRKLAKKRKETMS 778



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 74/302 (24%), Positives = 115/302 (38%), Gaps = 29/302 (9%)

Query: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531
           +G L P   Y + VL       G G P P ++ +T+   P + P   +       +I + 
Sbjct: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399

Query: 532 WLLPP----QERIIMYELV----YWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRF 580
           W   P      R   Y L     Y     E  + +V++D  +S+   T+ +L P T    
Sbjct: 400 W--EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSV 457

Query: 581 QLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT 640
           +L   +  G       I  +T +  P A P + +  S     + + W  P      GVIT
Sbjct: 458 KLILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVIT 514

Query: 641 QYSVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPE 695
            Y + Y+AV   D    + +   R       + +   GL   T Y   +RA T  G GP 
Sbjct: 515 LYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPP 574

Query: 696 SSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 755
           ++     T    PS P  ++E  PLN T   V   L     +   +  YQ+    +E   
Sbjct: 575 ATNQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEER 629

Query: 756 PR 757
           PR
Sbjct: 630 PR 631


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  496 bits (1277), Expect = e-140
 Identities = 271/601 (45%), Positives = 369/601 (61%), Gaps = 14/601 (2%)

Query: 1299 AHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTW 1358
            +H+    E   + YQT  +  HP I + DL  +I ++K  +G  F +EYES   GQ   W
Sbjct: 858  SHTYKKREPADVPYQTGQL--HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPW 915

Query: 1359 ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPL 1418
            +++  + N+ KNRY N+IAYDHSRV L +I+G   SDYIN NYIDGY + N YIATQGP+
Sbjct: 916  DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPM 975

Query: 1419 PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT 1478
             ET+ DFWRMVW + TA+++M+T L E  RVKC +YWP   TE    I+VTL++T  LA 
Sbjct: 976  QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAE 1034

Query: 1479 YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1538
            Y +RTFA+ K G  E RE+RQF F  WPDHGVP + T +L F+R+VK+ +P  AGP+VVH
Sbjct: 1035 YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVH 1094

Query: 1539 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1598
            CSAG GRTGCFIVID ML+  + E  VDIY  V  +RS+R  MVQTE+QYVFIH+A+LEA
Sbjct: 1095 CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA 1154

Query: 1599 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRFISANLPCNK 1656
              CG T VPA  + +    + ++ P  + + ++ EF+ L   +          A LP N 
Sbjct: 1155 CLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNH 1214

Query: 1657 FKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1716
             KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL  + +DFWR
Sbjct: 1215 EKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR 1273

Query: 1717 MLWEHNSTIIVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREF 1773
            ++ +++ T +VML  +     + C QYWP     R    Q   V    E ++   I R +
Sbjct: 1274 LVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIY 1331

Query: 1774 KVTDARDGQSRTIRQFQFTDWP-EQGVPKTGEGFIDFIGQVHKTKEQF-GQDGPITVHCS 1831
                 +DG  R ++QFQF  WP  +  P +   F+  I QV K +E++ G +G   VHC 
Sbjct: 1332 NAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390

Query: 1832 AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG 1891
             G GR+G F  +SIV E +R++  VD+F  VKTLR  +P MV   DQY+ CY  ALEYL 
Sbjct: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450

Query: 1892 S 1892
            S
Sbjct: 1451 S 1451



 Score =  137 bits (346), Expect = 8e-32
 Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)

Query: 1366 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1425
            N  KNR  +++  D     L +IDG   S+YINA  +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271

Query: 1426 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1485
            WR+V +    +VVM+  ++      C QYWP  G    G IQV  +          R F 
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329

Query: 1486 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1537
            ++ +   +   R ++QFQF+ WP +   + P    +FL+ ++  +          G  VV
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1387

Query: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
            HC  G GR+G F  I  + E ++H++TVD++  V  +R+ +  MV   DQY F +E  LE
Sbjct: 1388 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1447

Query: 1598 AATCG 1602
                G
Sbjct: 1448 YLNSG 1452



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)

Query: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295
           EV  G      C A+G  +   + W+ G +      KE ++   R  +   NVV +    
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254

Query: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345
              Y C+  +  G+ I   A++ VK   +PP+ +   +  +   T  W   N+       
Sbjct: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311

Query: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403
           P+    ++Y  A   G + +   V +T Y IG L P +EY   VL       G G P  A
Sbjct: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369

Query: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456
           +R RT    P   PR+++   + +  + ++WEP          Y   V+Y       +  
Sbjct: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429

Query: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515
           R   +W   N+      T+ +L P    S++++     G    S  + V+T + +P A P
Sbjct: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486

Query: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565
            +       + +I L W  P Q    I +YE+ Y A    D +  ++            +
Sbjct: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546

Query: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
            +    L P T Y F + A +  G G    T +  T  S PS P  ++    +  T   V
Sbjct: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604

Query: 626 SWVPPPADSRNGVITQYSVAYE 647
           + +  PA SR   ++ Y +  E
Sbjct: 605 TVMLKPAHSRGAPVSVYQIVVE 626



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 83/354 (23%), Positives = 131/354 (37%), Gaps = 45/354 (12%)

Query: 679  EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737
            +YR  +R  T+ G G  +   LV  +  VP  PP+   V      A +++ +L   S   
Sbjct: 257  KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309

Query: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG 797
             G I   +V Y           P+       ++    I  L P+T Y ++V   T  G+G
Sbjct: 310  DGPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEG 361

Query: 798  ARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRL--QYCR 850
                P     T       + G   + +         ++W P          Y L   YC 
Sbjct: 362  GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCY 421

Query: 851  ---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL 905
                 E     + +  ++ H   T+T L   T    +L   N  G  E  E  ++T EDL
Sbjct: 422  QVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDL 481

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS---QQELQN----- 957
            P   P              L W  P   +  G I  Y + ++ ++S   + +L N     
Sbjct: 482  PGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRV 539

Query: 958  --ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMPVEQV 1004
              +  +T F   GL P TTY   +RA T+KG GP      +  I + +MP  ++
Sbjct: 540  SKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYEL 593



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 961
            P   P+ L V  + +    + W+P        R  SY +       +  Q+++ + ++ D
Sbjct: 379  PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436

Query: 962  T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
            T     + T+T L P T   +K+     +G       I      +           +  +
Sbjct: 437  TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496

Query: 1017 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1061
              + L W  P  +Y     ++I Y   S    E+D           G+    L   L P 
Sbjct: 497  EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
            T YSF +  R S+A G                   PA+          SMP         
Sbjct: 557  TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590

Query: 1122 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1177
              Y +  P+++   +   ML P  S    + + +++  +E+  E  RR ++  E LK Y 
Sbjct: 591  --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644

Query: 1178 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1217
                             AA+         + FT+GD K Y G++N PL P  SY+ +  A
Sbjct: 645  VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704

Query: 1218 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1269
            + +   + K        + A++P       +  P  +++    + + G +  ++L ++I 
Sbjct: 705  ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757

Query: 1270 IAILLFKRKRTHSPSSKDEQS 1290
            + ++L  +KR  +   K+  S
Sbjct: 758  LGVVLVMKKRKLAKKRKETMS 778



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 74/302 (24%), Positives = 115/302 (38%), Gaps = 29/302 (9%)

Query: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531
           +G L P   Y + VL       G G P P ++ +T+   P + P   +       +I + 
Sbjct: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399

Query: 532 WLLPP----QERIIMYELV----YWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRF 580
           W   P      R   Y L     Y     E  + +V++D  +S+   T+ +L P T    
Sbjct: 400 W--EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSV 457

Query: 581 QLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT 640
           +L   +  G       I  +T +  P A P + +  S     + + W  P      GVIT
Sbjct: 458 KLILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVIT 514

Query: 641 QYSVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPE 695
            Y + Y+AV   D    + +   R       + +   GL   T Y   +RA T  G GP 
Sbjct: 515 LYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPP 574

Query: 696 SSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 755
           ++     T    PS P  ++E  PLN T   V   L     +   +  YQ+    +E   
Sbjct: 575 ATNQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEER 629

Query: 756 PR 757
           PR
Sbjct: 630 PR 631


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  464 bits (1195), Expect = e-130
 Identities = 342/1078 (31%), Positives = 513/1078 (47%), Gaps = 123/1078 (11%)

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 959
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 960  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500

Query: 1017 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1061
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1118
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619

Query: 1119 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1176
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663

Query: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1228
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723

Query: 1229 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1274
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV 783

Query: 1275 -FKRKRTHSPSSKD-----------EQSIGLK---------------------DSLLAHS 1301
             +++++TH  S+ D           ++ +GL                       SLL  S
Sbjct: 784  NYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS 843

Query: 1302 SD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1360
               P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES   G    W+ 
Sbjct: 844  PRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDA 897

Query: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1420
            +  +     +R   + AYD  RV L  + G P +DYINANYIDGY + N +IATQGP PE
Sbjct: 898  TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPE 957

Query: 1421 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYT 1480
             + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L+ T  LA Y 
Sbjct: 958  MVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYV 1016

Query: 1481 VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCS 1540
            VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P DAGP+V+HCS
Sbjct: 1017 VRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCS 1076

Query: 1541 AGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT 1600
            AG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+FIH+A+LEA  
Sbjct: 1077 AGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL 1136

Query: 1601 CGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLPCNKFK 1658
            CG T +P     A  +++ ++ P  + + +  EF+ L S            A LP N+ K
Sbjct: 1137 CGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDK 1196

Query: 1659 NRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1716
            NR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  +T DFWR
Sbjct: 1197 NRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWR 1253

Query: 1717 MLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1775
            +++++  T IVML +L +      C QYWP     +Y    V+ M+       + R F+V
Sbjct: 1254 LVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRV 1313

Query: 1776 TDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSA 1832
             +    Q     +R FQF  W   +  P + + F+  + +V K + + G DG   VHC  
Sbjct: 1314 QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLN 1372

Query: 1833 GVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1890
            G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  CY  ALEYL
Sbjct: 1373 GGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439

Query: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616

Query: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
            R   I+ Y V  E    E+R R +
Sbjct: 617 GRGAPISVYQVIVE----EERARRL 637



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 68/242 (28%), Positives = 92/242 (38%), Gaps = 43/242 (17%)

Query: 778 LTPETTYSVTVAAYTTKGDGARSKPK---IVTTTGAVPGRPTMMISTTAMNTA--LLQWH 832
           L P+T Y ++V   T  GDG   +P    I  T  A P R    ++   +      LQW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 833 PPKELPGELLGYRLQYCRA-----------DEARPNTI-DFGKDDQ---HFTVTGLHKGT 877
           P        LGY +  C               +   TI +  K +Q    +T+  L    
Sbjct: 406 P--------LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYR 457

Query: 878 TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERN 936
               RL   N  G  E  E   +T ED+PSG   ++L  T L      L W+ P   E N
Sbjct: 458 NVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIF-LKWEEP--QEPN 514

Query: 937 GRIISYTVVFRDINSQQELQNIT----------TDTRFTLTGLKPDTTYDIKVRAWTSKG 986
           G I  Y + ++ I S     N+            +T    + L P TTY   VRA T KG
Sbjct: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKG 574

Query: 987 SG 988
            G
Sbjct: 575 FG 576



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/352 (22%), Positives = 123/352 (34%), Gaps = 42/352 (11%)

Query: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314

Query: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369

Query: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419

Query: 754 --------GEPRGLPIIQDVMLAEA-QETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 804
                   G      I + V   +     TI  L P     V +     +G     +   
Sbjct: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTF 479

Query: 805 VTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARP------- 856
            T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + P       
Sbjct: 480 QTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGP 539

Query: 857 -NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 907
             TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 540 RRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564

Query: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621

Query: 544 ELVYWAAEDEDQQHKVTFDP 563
             VY    +E++  ++  +P
Sbjct: 622 ISVYQVIVEEERARRLRREP 641


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  461 bits (1185), Expect = e-129
 Identities = 342/1088 (31%), Positives = 513/1088 (47%), Gaps = 133/1088 (12%)

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 959
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 960  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500

Query: 1017 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1061
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1118
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619

Query: 1119 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1176
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663

Query: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1228
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723

Query: 1229 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1274
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYP 783

Query: 1275 -----------FKRKRTHSPSSKD-----------EQSIGLK------------------ 1294
                       +++++TH  S+ D           ++ +GL                   
Sbjct: 784  KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGV 843

Query: 1295 ---DSLLAHSSD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI 1350
                SLL  S   P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES 
Sbjct: 844  TEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESF 901

Query: 1351 DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNA 1410
              G    W+ +  +     +R   + AYD  RV L  + G P +DYINANYIDGY + N 
Sbjct: 902  FEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNH 957

Query: 1411 YIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL 1470
            +IATQGP PE + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L
Sbjct: 958  FIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIML 1016

Query: 1471 LDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL 1530
            + T  LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P 
Sbjct: 1017 VKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPP 1076

Query: 1531 DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF 1590
            DAGP+V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+F
Sbjct: 1077 DAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF 1136

Query: 1591 IHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFI 1648
            IH+A+LEA  CG T +P     A  +++ ++ P  + + +  EF+ L S           
Sbjct: 1137 IHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECS 1196

Query: 1649 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGP 1706
             A LP N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  P
Sbjct: 1197 IALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHP 1253

Query: 1707 LAESTEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNM 1765
            L  +T DFWR+++++  T IVML +L +      C QYWP     +Y    V+ M+    
Sbjct: 1254 LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTAD 1313

Query: 1766 PQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQ 1822
               + R F+V +    Q     +R FQF  W   +  P + + F+  + +V K + + G 
Sbjct: 1314 EDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG- 1372

Query: 1823 DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLC 1882
            DG   VHC  G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  C
Sbjct: 1373 DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFC 1432

Query: 1883 YRAALEYL 1890
            Y  ALEYL
Sbjct: 1433 YDVALEYL 1440



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439

Query: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616

Query: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
            R   I+ Y V  E    E+R R +
Sbjct: 617 GRGAPISVYQVIVE----EERARRL 637



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 68/242 (28%), Positives = 92/242 (38%), Gaps = 43/242 (17%)

Query: 778 LTPETTYSVTVAAYTTKGDGARSKPK---IVTTTGAVPGRPTMMISTTAMNTA--LLQWH 832
           L P+T Y ++V   T  GDG   +P    I  T  A P R    ++   +      LQW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 833 PPKELPGELLGYRLQYCRA-----------DEARPNTI-DFGKDDQ---HFTVTGLHKGT 877
           P        LGY +  C               +   TI +  K +Q    +T+  L    
Sbjct: 406 P--------LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYR 457

Query: 878 TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERN 936
               RL   N  G  E  E   +T ED+PSG   ++L  T L      L W+ P   E N
Sbjct: 458 NVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIF-LKWEEP--QEPN 514

Query: 937 GRIISYTVVFRDINSQQELQNIT----------TDTRFTLTGLKPDTTYDIKVRAWTSKG 986
           G I  Y + ++ I S     N+            +T    + L P TTY   VRA T KG
Sbjct: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKG 574

Query: 987 SG 988
            G
Sbjct: 575 FG 576



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/352 (22%), Positives = 123/352 (34%), Gaps = 42/352 (11%)

Query: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314

Query: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369

Query: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419

Query: 754 --------GEPRGLPIIQDVMLAEA-QETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 804
                   G      I + V   +     TI  L P     V +     +G     +   
Sbjct: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTF 479

Query: 805 VTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARP------- 856
            T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + P       
Sbjct: 480 QTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGP 539

Query: 857 -NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 907
             TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 540 RRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564

Query: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621

Query: 544 ELVYWAAEDEDQQHKVTFDP 563
             VY    +E++  ++  +P
Sbjct: 622 ISVYQVIVEEERARRLRREP 641


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  458 bits (1178), Expect = e-128
 Identities = 342/1084 (31%), Positives = 513/1084 (47%), Gaps = 129/1084 (11%)

Query: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 959
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 960  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500

Query: 1017 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1061
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560

Query: 1062 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1118
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619

Query: 1119 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1176
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663

Query: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1228
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723

Query: 1229 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1274
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV 783

Query: 1275 -FKRKRTHSPSSKD-----------EQSIGLK---------------------DSLLAHS 1301
             +++++TH  S+ D           ++ +GL                       SLL  S
Sbjct: 784  NYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS 843

Query: 1302 SD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1360
               P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES   G    W+ 
Sbjct: 844  PRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDA 897

Query: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIAT 1414
            +  +     +R   + AYD  RV L  + G P +DYINANYID      GY + N +IAT
Sbjct: 898  TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIAT 957

Query: 1415 QGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTV 1474
            QGP PE + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L+ T 
Sbjct: 958  QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTE 1016

Query: 1475 ELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGP 1534
             LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P DAGP
Sbjct: 1017 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1076

Query: 1535 MVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEA 1594
            +V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+FIH+A
Sbjct: 1077 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1136

Query: 1595 LLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANL 1652
            +LEA  CG T +P     A  +++ ++ P  + + +  EF+ L S            A L
Sbjct: 1137 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1196

Query: 1653 PCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAES 1710
            P N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  +
Sbjct: 1197 PRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQST 1253

Query: 1711 TEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1769
            T DFWR+++++  T IVML +L +      C QYWP     +Y    V+ M+       +
Sbjct: 1254 TPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLV 1313

Query: 1770 LREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826
             R F+V +    Q     +R FQF  W   +  P + + F+  + +V K + + G DG  
Sbjct: 1314 ARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRT 1372

Query: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886
             VHC  G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  CY  A
Sbjct: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432

Query: 1887 LEYL 1890
            LEYL
Sbjct: 1433 LEYL 1436



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439

Query: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616

Query: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
            R   I+ Y V  E    E+R R +
Sbjct: 617 GRGAPISVYQVIVE----EERARRL 637



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 68/242 (28%), Positives = 92/242 (38%), Gaps = 43/242 (17%)

Query: 778 LTPETTYSVTVAAYTTKGDGARSKPK---IVTTTGAVPGRPTMMISTTAMNTA--LLQWH 832
           L P+T Y ++V   T  GDG   +P    I  T  A P R    ++   +      LQW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 833 PPKELPGELLGYRLQYCRA-----------DEARPNTI-DFGKDDQ---HFTVTGLHKGT 877
           P        LGY +  C               +   TI +  K +Q    +T+  L    
Sbjct: 406 P--------LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYR 457

Query: 878 TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERN 936
               RL   N  G  E  E   +T ED+PSG   ++L  T L      L W+ P   E N
Sbjct: 458 NVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIF-LKWEEP--QEPN 514

Query: 937 GRIISYTVVFRDINSQQELQNIT----------TDTRFTLTGLKPDTTYDIKVRAWTSKG 986
           G I  Y + ++ I S     N+            +T    + L P TTY   VRA T KG
Sbjct: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKG 574

Query: 987 SG 988
            G
Sbjct: 575 FG 576



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/352 (22%), Positives = 123/352 (34%), Gaps = 42/352 (11%)

Query: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314

Query: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369

Query: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419

Query: 754 --------GEPRGLPIIQDVMLAEA-QETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 804
                   G      I + V   +     TI  L P     V +     +G     +   
Sbjct: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTF 479

Query: 805 VTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARP------- 856
            T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + P       
Sbjct: 480 QTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGP 539

Query: 857 -NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 907
             TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 540 RRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504

Query: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564

Query: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621

Query: 544 ELVYWAAEDEDQQHKVTFDP 563
             VY    +E++  ++  +P
Sbjct: 622 ISVYQVIVEEERARRLRREP 641


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  446 bits (1146), Expect = e-124
 Identities = 350/1152 (30%), Positives = 526/1152 (45%), Gaps = 143/1152 (12%)

Query: 806  TTTGAVPGRPTMMISTTAMNTALLQ--WHPPKEL-PGELLGYRLQYCRADEARPNTIDFG 862
            T    V   P + +    +N   LQ  W  P+ +    ++ Y + Y            F 
Sbjct: 340  TEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFT 399

Query: 863  KD---DQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHV-TGL 918
            KD   D   T++ +   + Y+FR+ A  R  +  +F + +    +    F     V TG+
Sbjct: 400  KDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGV 459

Query: 919  TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIK 978
             T++   + D   ++  +    S  + F  ++    +   ++ ++ T+  +   T     
Sbjct: 460  PTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTST----- 514

Query: 979  VRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAA---MKTSVLLSWEVPDSYKSAVPF 1035
            + A    G G +S S  S   P     A +    AA   + T+  L+   PD   S  P 
Sbjct: 515  LLAGLGFGGGGIS-SFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSS--PT 571

Query: 1036 KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIR--TAPDLLPH 1093
            K   +G+  E      +    D +   E      +      G+ H    R  T P   P 
Sbjct: 572  K---DGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPS 628

Query: 1094 KPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDEL 1153
             P   +    +G       H QD +         VP D+ GG                  
Sbjct: 629  SPNRTA----EGGHQTIPGHEQDHT--------AVPTDQTGG------------------ 658

Query: 1154 LEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQC 1213
                         RR     L P +     V P T T   ++ Y G  + P  P++    
Sbjct: 659  -------------RRDAGPGLDPDMVTSTQV-PPTAT---EEQYAG--SDPKRPEMPS-- 697

Query: 1214 FVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEP--------EMLWVTGPVLAV--- 1262
                  K+PM +    S    D   + V PA++             M W+  P++ V   
Sbjct: 698  ------KKPMSRGDRFSE---DSRFITVNPAEKNTSGMISRPAPGRMEWII-PLIVVSAL 747

Query: 1263 -ILIILIVIAILL------------FKRKRTHSPSSKDEQSIGLKDSL-LAH------SS 1302
              + ++++IA+L+            F R+    PSS +    G +     AH      SS
Sbjct: 748  TFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSS 807

Query: 1303 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID---PGQQFTWE 1359
              V         P   D   IP+     +I  L +N+   FS+++E +         T E
Sbjct: 808  PRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAE 867

Query: 1360 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGP 1417
            +SN   NK KNRY N++AYDHSRV L  + G     SDYINANY+DGY K  AYIATQGP
Sbjct: 868  HSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGP 927

Query: 1418 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1477
            L  T  DFWRM+WEQ T  +VM+T L EK R KCDQYWP   +E  G I VTL  T   A
Sbjct: 928  LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA 987

Query: 1478 TYTVRTFALHKS-----------GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKA 1526
             YTVR F++  +           G   +R + Q+ +  WPD GVPEY  P+L F+RR  A
Sbjct: 988  CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA 1047

Query: 1527 CNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTED 1586
                + GP++VHCSAGVGRTG +IVID+ML+++K + TV++ G +  +R+QRNY+VQTE+
Sbjct: 1048 ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEE 1107

Query: 1587 QYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSR 1646
            QY+FIH+ALLEA     TEV +  L++++  +  +P     T +E +FKL+    A    
Sbjct: 1108 QYIFIHDALLEAILGKETEVSSNQLHSYVNSI-LIPGVGGKTRLEKQFKLVTQCNAKYVE 1166

Query: 1647 FISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGP 1706
              SA   CNK KNR  +++P E  RV L P+ G++G+DYINAS++ GY +   +I TQ P
Sbjct: 1167 CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHP 1226

Query: 1707 LAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPM 1760
            L  +T+DFWRM+W+HN+ IIVML   + +  ++   YWP+ E S   + F V     D +
Sbjct: 1227 LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRL 1285

Query: 1761 AEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF 1820
               N  Q I+ +F +   +D     +R FQ   WP    P +     + I  +   +E  
Sbjct: 1286 CLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEAL 1341

Query: 1821 GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQ 1880
             +DGP  VH   G    G+   L+ + +++  E  VD+FQ  K +   RP +    +QYQ
Sbjct: 1342 TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQ 1401

Query: 1881 LCYRAALEYLGS 1892
              Y+A L  + +
Sbjct: 1402 FIYKAMLSLVST 1413



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 3/84 (3%)

Query: 707 VPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM 766
           V S PP  ++V+PLN TA+ V W  P  +  H  I  Y ++Y   +N + +     +D  
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD-- 401

Query: 767 LAEAQETTISGLTPETTYSVTVAA 790
             +  + TIS ++P++ Y   V A
Sbjct: 402 SDKDLKATISHVSPDSLYLFRVQA 425



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 24/138 (17%)

Query: 515 PADFQAEVESDTRIQLSWLLPP---QERIIMYELVYWAAEDEDQQHKVTF----DPTSSY 567
           P   + +  + T +Q+SW  P       I+ Y + Y   ++ED++ K TF    D     
Sbjct: 350 PIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEK-TFTKDSDKDLKA 408

Query: 568 TLEDLKPDTLYRFQLAA------RSDMGVGVFTPTIEARTAQST-------PSAPPQK-- 612
           T+  + PD+LY F++ A      RSD    +       R  Q T       P+A P    
Sbjct: 409 TISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSA 468

Query: 613 -VMCVSMGSTTVRVSWVP 629
            +  +S GS+T   S +P
Sbjct: 469 DMAPISSGSSTWTSSGIP 486


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  422 bits (1084), Expect = e-117
 Identities = 264/727 (36%), Positives = 386/727 (53%), Gaps = 52/727 (7%)

Query: 1192 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1251
            GD +   GF   P SP  S    V +   E        +S  S E  + +    + E+  
Sbjct: 1585 GDSEITPGF---PQSPTSS----VTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA 1637

Query: 1252 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1311
            ++ +        + +++++ IL++ RK   +     E S   +  +++    P+      
Sbjct: 1638 VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR--VISTPPTPI------ 1689

Query: 1312 YQTPGMRDHPPIPITDLADNIERLKANDGL--------KFSQEYESIDPGQQFTWENSNL 1363
               P   D   IPI     ++  L A+ G         +F QE +S       T ++SN 
Sbjct: 1690 --FPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNH 1747

Query: 1364 EVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGPLPET 1421
              NK KNRY N++AYDHSRV L  +    G  +DYINANY+DGY +  AYIA QGPL  T
Sbjct: 1748 PDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKST 1807

Query: 1422 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1481
              DFWRM+WE     +VM+T L EK R KCDQYWPA G+E  G   VT      LA YTV
Sbjct: 1808 AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTV 1867

Query: 1482 RTFALH----KSGSSEKRE----LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAG 1533
            R F L     K GS + R     + Q+ +  WPD GVPEY  P+L F+R+         G
Sbjct: 1868 RNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG 1927

Query: 1534 PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE 1593
            P+VVHCSAGVGRTG +IV+D+ML++++HE TV+I+G +  +RSQRNY+VQTE+QYVFIH+
Sbjct: 1928 PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD 1987

Query: 1594 ALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLP 1653
             L+EA     TEV   +++A++  L  +P     T +E +F+LL+ S    S + +A   
Sbjct: 1988 TLVEAILSKETEVLDSHIHAYVNAL-LIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQ 2046

Query: 1654 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1713
            CN+ KNR  +I+P E +RV +  + G EG+DYINAS++ GY Q   +I TQ PL  + +D
Sbjct: 2047 CNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKD 2105

Query: 1714 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQ 1767
            FWRM+W+HN+ ++VM+   + M  ++   YWP  +     + F V  MAE      N  +
Sbjct: 2106 FWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEK 2164

Query: 1768 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDFIGQVHKTKEQFGQDGP 1825
             I+++F +   +D     +R FQ   WP    P  KT E  I  I      +E   +DGP
Sbjct: 2165 LIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFE-LISVI-----KEEAANRDGP 2218

Query: 1826 ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRA 1885
            + VH   G    G F  L+ ++ ++  E  VD++Q  K +   RP +    +QYQ  Y+ 
Sbjct: 2219 MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV 2278

Query: 1886 ALEYLGS 1892
             L  + +
Sbjct: 2279 ILSLVST 2285



 Score =  119 bits (298), Expect = 3e-26
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 10/264 (3%)

Query: 1354 QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIA 1413
            QQ  +  +  + N+ KNR +++I  + SRV ++S+ G  G+DYINA+YI GY + N +I 
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094

Query: 1414 TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLD 1472
            TQ PL  T+ DFWRM+W+     VVM+   +  +  +   YWP +     C   +VTL+ 
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153

Query: 1473 TVELATYT-----VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC 1527
                         ++ F L  +      E+R FQ   WP+   P   T  L  + + +A 
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213

Query: 1528 NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ 1587
            N    GPM+VH   G    G F  +  ++ +++ E +VD+Y     +   R  +    +Q
Sbjct: 2214 NR--DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271

Query: 1588 YVFIHEALLEAATCGHTEVPARNL 1611
            Y F+++ +L   +    E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 536  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 581

Query: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1377
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 582  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 638

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 639  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 698

Query: 1438 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1494
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 699  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 758

Query: 1495 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1554
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 759  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 818

Query: 1555 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1614
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 819  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 878

Query: 1615 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1674
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 879  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 937

Query: 1675 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1715
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 938  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 997

Query: 1716 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1775
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 998  QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 1056

Query: 1776 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1827
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 1057 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116

Query: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172



 Score =  197 bits (500), Expect = 1e-49
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681

Query: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1767
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741

Query: 1768 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799

Query: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1887 LEY 1889
            +EY
Sbjct: 860  VEY 862



 Score =  156 bits (395), Expect = 2e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 1362 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1402
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 914  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 973

Query: 1403 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1462
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 974  MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 1032

Query: 1463 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1522
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 1033 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1092

Query: 1523 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1572
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 1093 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1152

Query: 1573 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1610
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1153 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1190


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 584  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 629

Query: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1377
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 630  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 686

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 687  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 746

Query: 1438 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1494
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 747  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 806

Query: 1495 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1554
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 807  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 866

Query: 1555 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1614
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 867  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 926

Query: 1615 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1674
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 927  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 985

Query: 1675 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1715
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 986  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 1045

Query: 1716 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1775
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 1046 QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 1104

Query: 1776 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1827
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 1105 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1164

Query: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1165 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220



 Score =  197 bits (500), Expect = 1e-49
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 670  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729

Query: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1767
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 730  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789

Query: 1768 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 790  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847

Query: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1887 LEY 1889
            +EY
Sbjct: 908  VEY 910



 Score =  156 bits (395), Expect = 2e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 1362 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1402
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 962  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 1021

Query: 1403 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1462
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 1022 MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 1080

Query: 1463 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1522
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 1081 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1140

Query: 1523 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1572
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 1141 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1200

Query: 1573 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1610
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1201 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1238


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 423  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 468

Query: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1377
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 469  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 525

Query: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 526  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 585

Query: 1438 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1494
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 586  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 645

Query: 1495 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1554
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 646  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 705

Query: 1555 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1614
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 706  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 765

Query: 1615 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1674
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 766  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 824

Query: 1675 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1715
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 825  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 884

Query: 1716 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1775
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 885  QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 943

Query: 1776 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1827
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 944  RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003

Query: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059



 Score =  197 bits (500), Expect = 1e-49
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 509  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568

Query: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1767
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 569  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628

Query: 1768 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 629  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686

Query: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1887 LEY 1889
            +EY
Sbjct: 747  VEY 749



 Score =  156 bits (395), Expect = 2e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 1362 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1402
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 801  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 860

Query: 1403 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1462
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 861  MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 919

Query: 1463 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1522
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 920  YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 979

Query: 1523 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1572
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 980  VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1039

Query: 1573 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1610
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1040 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1077


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,905,054
Number of Sequences: 37866
Number of extensions: 3858802
Number of successful extensions: 22968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 348
Number of HSP's successfully gapped in prelim test: 230
Number of HSP's that attempted gapping in prelim test: 10228
Number of HSP's gapped (non-prelim): 4651
length of query: 1898
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1781
effective length of database: 13,817,196
effective search space: 24608426076
effective search space used: 24608426076
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.