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Search of human proteins with 109255245
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109255245 serine/threonine kinase 17a [Homo sapiens]
(414 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 824 0.0
gi|4758194 serine/threonine kinase 17B [Homo sapiens] 375 e-104
gi|14670383 death-associated kinase 2 [Homo sapiens] 255 6e-68
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 253 2e-67
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 251 7e-67
gi|146219832 myosin light chain kinase 3 [Homo sapiens] 212 4e-55
gi|14993776 skeletal myosin light chain kinase [Homo sapiens] 212 6e-55
gi|167466233 myosin light chain kinase family, member 4 [Homo sa... 209 3e-54
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 207 2e-53
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 207 2e-53
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 200 2e-51
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 200 2e-51
gi|110349719 titin isoform N2-A [Homo sapiens] 194 1e-49
gi|110349717 titin isoform novex-2 [Homo sapiens] 194 1e-49
gi|110349713 titin isoform novex-1 [Homo sapiens] 194 1e-49
gi|110349715 titin isoform N2-B [Homo sapiens] 194 1e-49
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 186 3e-47
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 184 2e-46
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 184 2e-46
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 179 5e-45
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 179 5e-45
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 179 5e-45
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 179 5e-45
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 179 5e-45
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 178 9e-45
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 178 9e-45
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 178 9e-45
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 178 9e-45
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 178 9e-45
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 178 9e-45
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 824 bits (2129), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS 60
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS
Sbjct: 1 MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS 60
Query: 61 LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW 120
LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW
Sbjct: 61 LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW 120
Query: 121 VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR 180
VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR
Sbjct: 121 VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR 180
Query: 181 DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI 240
DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI
Sbjct: 181 DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI 240
Query: 241 SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT 300
SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT
Sbjct: 241 SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT 300
Query: 301 LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE 360
LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE
Sbjct: 301 LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE 360
Query: 361 TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY 414
TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Sbjct: 361 TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY 414
>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
Length = 372
Score = 375 bits (963), Expect = e-104
Identities = 200/365 (54%), Positives = 256/365 (70%), Gaps = 18/365 (4%)
Query: 41 GLLTEIRAV-VRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQ 99
GLLT + ++ E F + Y L +ELGRGKFAVVR+CI K +G+E+AAKF++KRR+GQ
Sbjct: 13 GLLTTTPQIPIKMENFNNFYILT-SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQ 71
Query: 100 DCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFK 159
DCR EI+HEIAVLELA+ P VINLHEVYE SE+IL+LEYAAGGEIF C+ + E
Sbjct: 72 DCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVS 131
Query: 160 EKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEE 219
E DV RL++QILEGV++LH ++VHLDLKPQNILL+S PLGDIKIVDFG+SR + ++ E
Sbjct: 132 ENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE 191
Query: 220 LREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMN 279
LREIMGTPEY+APEIL+YDPI+ ATDMW+IG++ Y++LT SPF+G D QET+LNISQ+N
Sbjct: 192 LREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVN 251
Query: 280 LSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEE 339
+ YSEE F +S+ A DFI++LLVK PE R TAE CL H WL Q E F E+
Sbjct: 252 VDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDF-ENLFHPEET--S 308
Query: 340 ANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFK 399
+++ + HSV T KS + T G E + +SKRF+
Sbjct: 309 SSSQTQDHSVRSSEDKTSKSS-------------CNGTCGDREDKENIPEDSSMVSKRFR 355
Query: 400 FEEPL 404
F++ L
Sbjct: 356 FDDSL 360
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 255 bits (651), Expect = 6e-68
Identities = 132/300 (44%), Positives = 200/300 (66%), Gaps = 17/300 (5%)
Query: 53 EPF-----QDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKR-----RKGQDCR 102
EPF +D Y + G ELG G+FA+V+KC +K +G E+AAKF++KR R+G R
Sbjct: 12 EPFKQQKVEDFYDI--GEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVS-R 68
Query: 103 MEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKD 162
EI E+++L + VI LH+VYE ++++L+LE +GGE+FD ++E+ E++
Sbjct: 69 EEIEREVSILRQVLHHN-VITLHDVYENRTDVVLILELVSGGELFDFLA--QKESLSEEE 125
Query: 163 VQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELR 221
++QIL+GV++LHT+ + H DLKP+NI+L ++ P+ IK++DFGL+ +++ E +
Sbjct: 126 ATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFK 185
Query: 222 EIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLS 281
I GTPE+VAPEI++Y+P+ + DMWSIGV+TY++L+G SPFLG+ KQET NI+ ++
Sbjct: 186 NIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYD 245
Query: 282 YSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEAN 341
+ EE F SE A DFIR LLVK+ R T +E L+HPW+T Q+ R E + N
Sbjct: 246 FDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLEN 305
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 253 bits (646), Expect = 2e-67
Identities = 132/294 (44%), Positives = 190/294 (64%), Gaps = 10/294 (3%)
Query: 49 VVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQD----CRME 104
V R E D Y G ELG G+FAVV+KC +K +G ++AAKF++KRR R +
Sbjct: 3 VFRQENVDDYYDT--GEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
Query: 105 IIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQ 164
I E+++L+ Q +P VI LHEVYE +++IL+LE AGGE+FD +E+ E++
Sbjct: 61 IEREVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLA--EKESLTEEEAT 117
Query: 165 RLMRQILEGVHFLHTRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREI 223
++QIL GV++LH+ + H DLKP+NI+L + P IKI+DFGL+ + E + I
Sbjct: 118 EFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNI 177
Query: 224 MGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYS 283
GTPE+VAPEI++Y+P+ + DMWSIGV+TY++L+G SPFLG+ KQET N+S +N +
Sbjct: 178 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFE 237
Query: 284 EEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKAL 337
+E F S A DFIR LLVK P+ R T ++ L+HPW+ Q+ R A+
Sbjct: 238 DEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAV 291
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 251 bits (642), Expect = 7e-67
Identities = 125/276 (45%), Positives = 187/276 (67%), Gaps = 10/276 (3%)
Query: 51 RTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQD----CRMEII 106
R E +D Y + G ELG G+FA+VRKC +K +GKE+AAKF++KRR R EI
Sbjct: 5 RQEDVEDHYEM--GEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIE 62
Query: 107 HEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRL 166
E+ +L + +P +I LH+++E ++++L+LE +GGE+FD +E+ E + +
Sbjct: 63 REVNILREIR-HPNIITLHDIFENKTDVVLILELVSGGELFDFLA--EKESLTEDEATQF 119
Query: 167 MRQILEGVHFLHTRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREIMG 225
++QIL+GVH+LH++ + H DLKP+NI+L ++ P IK++DFG++ ++ E + I G
Sbjct: 120 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 179
Query: 226 TPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEE 285
TPE+VAPEI++Y+P+ + DMWSIGV+TY++L+G SPFLG KQET NIS +N + EE
Sbjct: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEE 239
Query: 286 EFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321
F SE A DFIR LLVK P+ R T + L+H W+
Sbjct: 240 YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275
>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
Length = 819
Score = 212 bits (540), Expect = 4e-55
Identities = 123/309 (39%), Positives = 183/309 (59%), Gaps = 17/309 (5%)
Query: 14 PGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFA 73
PGA +GS L PP P + R + V+ GY +C LG G+F
Sbjct: 478 PGAEAGSVV----LDDSPAPPAPFEHRVVS------VKETSISAGYEVCQHEVLGGGRFG 527
Query: 74 VVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVL-ELAQDNPWVINLHEVYETAS 132
V +C +K +G AAK ++ K R ++ +EI ++ +L+ N +I L++ +E+
Sbjct: 528 QVHRCTEKSTGLPLAAKIIKV--KSAKDREDVKNEINIMNQLSHVN--LIQLYDAFESKH 583
Query: 133 EMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNI 192
LV+EY GGE+FD+ + D + E DV RQI EGVH+LH ++HLDLKP+NI
Sbjct: 584 SCTLVMEYVDGGELFDR-ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENI 642
Query: 193 LLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVL 252
L +++ IKI+DFGL+R K E+L+ GTPE++APE+++Y+ +S TDMWS+GV+
Sbjct: 643 LCVNQTG-HQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVI 701
Query: 253 TYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATA 312
TY++L+G+SPFLG ET I + + + F+ LSE A DF+ LLVK+ R +A
Sbjct: 702 TYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSA 761
Query: 313 EECLKHPWL 321
+CLKH WL
Sbjct: 762 TQCLKHEWL 770
>gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
Length = 596
Score = 212 bits (539), Expect = 6e-55
Identities = 119/315 (37%), Positives = 188/315 (59%), Gaps = 12/315 (3%)
Query: 31 CRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAK 90
C PPP P ++ +RT +S+ LG GKF V C++K +G + AAK
Sbjct: 260 CPPPPAPFPHRMVE-----LRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAK 314
Query: 91 FMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQC 150
++K+ +D M ++ + +L N +I L+ ET E++L +EY GGE+F++
Sbjct: 315 VIKKQTP-KDKEMVLLEIEVMNQLNHRN--LIQLYAAIETPHEIVLFMEYIEGGELFERI 371
Query: 151 VADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGL 210
V D + E D +RQI +G+ F+H V+HLDLKP+NIL + + +KI+DFGL
Sbjct: 372 V-DEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTG-HLVKIIDFGL 429
Query: 211 SRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQE 270
+R +E+L+ GTPE+++PE+++YD IS TDMWS+GV+TY++L+G+SPFLG+D E
Sbjct: 430 ARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTE 489
Query: 271 TFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPS 330
T N+ N + EE F+ +S+ A DF+ L+VK R A +CL HPWL +++ E +
Sbjct: 490 TLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL--NNLAEKA 547
Query: 331 FRMEKALEEANALQE 345
R + L+ L++
Sbjct: 548 KRCNRRLKSQILLKK 562
>gi|167466233 myosin light chain kinase family, member 4 [Homo
sapiens]
Length = 388
Score = 209 bits (533), Expect = 3e-54
Identities = 114/293 (38%), Positives = 178/293 (60%), Gaps = 10/293 (3%)
Query: 34 PPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMR 93
PP P ++T + V + Y++ LG G+F V KC + +G + AAK ++
Sbjct: 84 PPAPFDHRIVTAKQGAVNSF-----YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIK 138
Query: 94 KRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVAD 153
R G + E+ +EI+V+ D+ +I L++ +E+ ++++LV+EY GGE+FD+ + D
Sbjct: 139 TR--GMKDKEEVKNEISVMNQL-DHANLIQLYDAFESKNDIVLVMEYVDGGELFDRII-D 194
Query: 154 REEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRI 213
E D M+QI EG+ +H ++HLDLKP+NIL + IKI+DFGL+R
Sbjct: 195 ESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAK-QIKIIDFGLARR 253
Query: 214 LKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFL 273
K E+L+ GTPE++APE+++YD +S TDMWS+GV+ Y++L+G+SPFLG++ ET
Sbjct: 254 YKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLN 313
Query: 274 NISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSI 326
NI +EEF +SE A +FI LL+K+ R +A E LKHPWL+ +
Sbjct: 314 NILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKL 366
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 207 bits (526), Expect = 2e-53
Identities = 100/269 (37%), Positives = 174/269 (64%), Gaps = 5/269 (1%)
Query: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHE 126
LG GKF V + ++K + K +A KF + + + I EI+++ +P ++ +
Sbjct: 1470 LGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKE--KENIRQEISIMNCLH-HPKLVQCVD 1526
Query: 127 VYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLD 186
+E + +++VLE +GGE+F++ + D + E++ + MRQI EGV ++H + +VHLD
Sbjct: 1527 AFEEKANIVMVLEIVSGGELFERII-DEDFELTERECIKYMRQISEGVEYIHKQGIVHLD 1585
Query: 187 LKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDM 246
LKP+NI+ +++ IK++DFGL+R L+N+ L+ + GTPE+VAPE+++Y+PI ATDM
Sbjct: 1586 LKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDM 1644
Query: 247 WSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKP 306
WSIGV+ Y++++G+SPF+G++ ET N++ + +E FD +S+ A DFI LL K
Sbjct: 1645 WSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDM 1704
Query: 307 EDRATAEECLKHPWLTQSSIQEPSFRMEK 335
++R +CL+HPWL + + + ++ K
Sbjct: 1705 KNRLDCTQCLQHPWLMKDTKNMEAKKLSK 1733
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 207 bits (526), Expect = 2e-53
Identities = 100/269 (37%), Positives = 174/269 (64%), Gaps = 5/269 (1%)
Query: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHE 126
LG GKF V + ++K + K +A KF + + + I EI+++ +P ++ +
Sbjct: 1401 LGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKE--KENIRQEISIMNCLH-HPKLVQCVD 1457
Query: 127 VYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLD 186
+E + +++VLE +GGE+F++ + D + E++ + MRQI EGV ++H + +VHLD
Sbjct: 1458 AFEEKANIVMVLEIVSGGELFERII-DEDFELTERECIKYMRQISEGVEYIHKQGIVHLD 1516
Query: 187 LKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDM 246
LKP+NI+ +++ IK++DFGL+R L+N+ L+ + GTPE+VAPE+++Y+PI ATDM
Sbjct: 1517 LKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDM 1575
Query: 247 WSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKP 306
WSIGV+ Y++++G+SPF+G++ ET N++ + +E FD +S+ A DFI LL K
Sbjct: 1576 WSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDM 1635
Query: 307 EDRATAEECLKHPWLTQSSIQEPSFRMEK 335
++R +CL+HPWL + + + ++ K
Sbjct: 1636 KNRLDCTQCLQHPWLMKDTKNMEAKKLSK 1664
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 200 bits (508), Expect = 2e-51
Identities = 107/294 (36%), Positives = 175/294 (59%), Gaps = 11/294 (3%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
E+GRG+F++V+KCI K + K+ A KF+ K+ K ++ + HE A+L+ Q +P I LH
Sbjct: 2689 EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKE---QAAHEAALLQHLQ-HPQYITLH 2744
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
+ YE+ + IL+LE G + D + + +E +EK V +R I+E + +LH V HL
Sbjct: 2745 DTYESPTSYILILELMDDGRLLDYLM-NHDELMEEK-VAFYIRDIMEALQYLHNCRVAHL 2802
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
D+KP+N+L+ P+ +K++D + + + ++G PE+ APE++ P+S+ TD
Sbjct: 2803 DIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTD 2862
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
+WSIGVLTYVML+G+SPFL K+ET +N+ +++ S+ E F +S +A DFI +L +
Sbjct: 2863 IWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQED 2922
Query: 306 PEDRATAEECLKHPWL-----TQSSIQEPSFRMEKALEEANALQEGHSVPEINS 354
R TA CL+HPWL + S I + R+ +E + +P + S
Sbjct: 2923 FRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKS 2976
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 200 bits (508), Expect = 2e-51
Identities = 107/294 (36%), Positives = 175/294 (59%), Gaps = 11/294 (3%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
E+GRG+F++V+KCI K + K+ A KF+ K+ K ++ + HE A+L+ Q +P I LH
Sbjct: 992 EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKE---QAAHEAALLQHLQ-HPQYITLH 1047
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
+ YE+ + IL+LE G + D + + +E +EK V +R I+E + +LH V HL
Sbjct: 1048 DTYESPTSYILILELMDDGRLLDYLM-NHDELMEEK-VAFYIRDIMEALQYLHNCRVAHL 1105
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
D+KP+N+L+ P+ +K++D + + + ++G PE+ APE++ P+S+ TD
Sbjct: 1106 DIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTD 1165
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
+WSIGVLTYVML+G+SPFL K+ET +N+ +++ S+ E F +S +A DFI +L +
Sbjct: 1166 IWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQED 1225
Query: 306 PEDRATAEECLKHPWL-----TQSSIQEPSFRMEKALEEANALQEGHSVPEINS 354
R TA CL+HPWL + S I + R+ +E + +P + S
Sbjct: 1226 FRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKS 1279
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 194 bits (493), Expect = 1e-49
Identities = 100/273 (36%), Positives = 170/273 (62%), Gaps = 7/273 (2%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
+LGRG+F +V +C++ S K + AKF++ KG D ++ + EI++L +A+ +++LH
Sbjct: 31256 DLGRGEFGIVHRCVETSSKKTYMAKFVKV--KGTD-QVLVKKEISILNIARHRN-ILHLH 31311
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
E +E+ E++++ E+ +G +IF++ E E+++ + Q+ E + FLH+ ++ H
Sbjct: 31312 ESFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHF 31370
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
D++P+NI+ + IKI++FG +R LK + R + PEY APE+ +D +S ATD
Sbjct: 31371 DIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATD 31429
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
MWS+G L YV+L+GI+PFL Q+ NI ++ EE F +S A+DF+ LLVK+
Sbjct: 31430 MWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKE 31489
Query: 306 PEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
+ R TA E L+HPWL Q I+ S ++ + L+
Sbjct: 31490 RKSRMTASEALQHPWLKQ-KIERVSTKVIRTLK 31521
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 194 bits (493), Expect = 1e-49
Identities = 100/273 (36%), Positives = 170/273 (62%), Gaps = 7/273 (2%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
+LGRG+F +V +C++ S K + AKF++ KG D ++ + EI++L +A+ +++LH
Sbjct: 24951 DLGRGEFGIVHRCVETSSKKTYMAKFVKV--KGTD-QVLVKKEISILNIARHRN-ILHLH 25006
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
E +E+ E++++ E+ +G +IF++ E E+++ + Q+ E + FLH+ ++ H
Sbjct: 25007 ESFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHF 25065
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
D++P+NI+ + IKI++FG +R LK + R + PEY APE+ +D +S ATD
Sbjct: 25066 DIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATD 25124
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
MWS+G L YV+L+GI+PFL Q+ NI ++ EE F +S A+DF+ LLVK+
Sbjct: 25125 MWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKE 25184
Query: 306 PEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
+ R TA E L+HPWL Q I+ S ++ + L+
Sbjct: 25185 RKSRMTASEALQHPWLKQ-KIERVSTKVIRTLK 25216
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 194 bits (493), Expect = 1e-49
Identities = 100/273 (36%), Positives = 170/273 (62%), Gaps = 7/273 (2%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
+LGRG+F +V +C++ S K + AKF++ KG D ++ + EI++L +A+ +++LH
Sbjct: 24884 DLGRGEFGIVHRCVETSSKKTYMAKFVKV--KGTD-QVLVKKEISILNIARHRN-ILHLH 24939
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
E +E+ E++++ E+ +G +IF++ E E+++ + Q+ E + FLH+ ++ H
Sbjct: 24940 ESFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHF 24998
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
D++P+NI+ + IKI++FG +R LK + R + PEY APE+ +D +S ATD
Sbjct: 24999 DIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATD 25057
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
MWS+G L YV+L+GI+PFL Q+ NI ++ EE F +S A+DF+ LLVK+
Sbjct: 25058 MWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKE 25117
Query: 306 PEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
+ R TA E L+HPWL Q I+ S ++ + L+
Sbjct: 25118 RKSRMTASEALQHPWLKQ-KIERVSTKVIRTLK 25149
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 194 bits (493), Expect = 1e-49
Identities = 100/273 (36%), Positives = 170/273 (62%), Gaps = 7/273 (2%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
+LGRG+F +V +C++ S K + AKF++ KG D ++ + EI++L +A+ +++LH
Sbjct: 24759 DLGRGEFGIVHRCVETSSKKTYMAKFVKV--KGTD-QVLVKKEISILNIARHRN-ILHLH 24814
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
E +E+ E++++ E+ +G +IF++ E E+++ + Q+ E + FLH+ ++ H
Sbjct: 24815 ESFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHF 24873
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
D++P+NI+ + IKI++FG +R LK + R + PEY APE+ +D +S ATD
Sbjct: 24874 DIRPENIIYQTRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATD 24932
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
MWS+G L YV+L+GI+PFL Q+ NI ++ EE F +S A+DF+ LLVK+
Sbjct: 24933 MWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKE 24992
Query: 306 PEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
+ R TA E L+HPWL Q I+ S ++ + L+
Sbjct: 24993 RKSRMTASEALQHPWLKQ-KIERVSTKVIRTLK 25024
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 186 bits (472), Expect = 3e-47
Identities = 98/256 (38%), Positives = 161/256 (62%), Gaps = 6/256 (2%)
Query: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
ELGRG+F+VV+KC +K + + A KF+ K+ +D ++ HE+ +L+ Q +P ++ L
Sbjct: 2801 ELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRD---QVTHELGILQSLQ-HPLLVGLL 2856
Query: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
+ +ET + ILVLE A G + D CV R + E ++ + ++LE V +LH + HL
Sbjct: 2857 DTFETPTSYILVLEMADQGRLLD-CVV-RWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHL 2914
Query: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
DLKP+NIL+ IK+ DFG + L + + +++G PE+ APEI+ +P+S+ +D
Sbjct: 2915 DLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSD 2974
Query: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
WS+GVLTYV+L+G+SPFL + +ET LNI +++ S+ ++ F +S+ A +F+ LL +
Sbjct: 2975 TWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQED 3034
Query: 306 PEDRATAEECLKHPWL 321
P R +A L+ WL
Sbjct: 3035 PAKRPSAALALQEQWL 3050
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 184 bits (466), Expect = 2e-46
Identities = 100/257 (38%), Positives = 155/257 (60%), Gaps = 8/257 (3%)
Query: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRR-KGQDCRMEIIHEIAVL-ELAQDNPWVINL 124
LG G F+ V +K +GK FA K + K+ KG++ +E +EIAVL ++ +N ++ L
Sbjct: 29 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIE--NEIAVLRKIKHEN--IVAL 84
Query: 125 HEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVH 184
++YE+ + + LV++ +GGE+FD+ V + + EKD L+RQ+L+ V++LH +VH
Sbjct: 85 EDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 185 LDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMAT 244
DLKP+N+L S+ I I DFGLS++ + + GTP YVAPE+L+ P S A
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202
Query: 245 DMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVK 304
D WSIGV+ Y++L G PF + + F I + + +D +S+SA DFIR L+ K
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEK 262
Query: 305 KPEDRATAEECLKHPWL 321
P R T E+ +HPW+
Sbjct: 263 DPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 184 bits (466), Expect = 2e-46
Identities = 100/257 (38%), Positives = 155/257 (60%), Gaps = 8/257 (3%)
Query: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRR-KGQDCRMEIIHEIAVL-ELAQDNPWVINL 124
LG G F+ V +K +GK FA K + K+ KG++ +E +EIAVL ++ +N ++ L
Sbjct: 29 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIE--NEIAVLRKIKHEN--IVAL 84
Query: 125 HEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVH 184
++YE+ + + LV++ +GGE+FD+ V + + EKD L+RQ+L+ V++LH +VH
Sbjct: 85 EDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 185 LDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMAT 244
DLKP+N+L S+ I I DFGLS++ + + GTP YVAPE+L+ P S A
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202
Query: 245 DMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVK 304
D WSIGV+ Y++L G PF + + F I + + +D +S+SA DFIR L+ K
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEK 262
Query: 305 KPEDRATAEECLKHPWL 321
P R T E+ +HPW+
Sbjct: 263 DPNKRYTCEQAARHPWI 279
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 179 bits (453), Expect = 5e-45
Identities = 95/285 (33%), Positives = 153/285 (53%), Gaps = 6/285 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+KK S +E+AAK + ++ ++ E + L
Sbjct: 10 FTDDYQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D + QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ +H D+VH DLKP+N+LL S+ +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP D+W+ GV+ Y++L G PF D+ + + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
A + I +L P R TA++ LKHPW+ Q S ++ +E
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 289
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 179 bits (453), Expect = 5e-45
Identities = 95/285 (33%), Positives = 153/285 (53%), Gaps = 6/285 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+KK S +E+AAK + ++ ++ E + L
Sbjct: 10 FTDDYQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D + QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ +H D+VH DLKP+N+LL S+ +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP D+W+ GV+ Y++L G PF D+ + + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
A + I +L P R TA++ LKHPW+ Q S ++ +E
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 289
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 179 bits (453), Expect = 5e-45
Identities = 95/285 (33%), Positives = 153/285 (53%), Gaps = 6/285 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+KK S +E+AAK + ++ ++ E + L
Sbjct: 10 FTDDYQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D + QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ +H D+VH DLKP+N+LL S+ +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP D+W+ GV+ Y++L G PF D+ + + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
A + I +L P R TA++ LKHPW+ Q S ++ +E
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 289
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 179 bits (453), Expect = 5e-45
Identities = 95/285 (33%), Positives = 153/285 (53%), Gaps = 6/285 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+KK S +E+AAK + ++ ++ E + L
Sbjct: 10 FTDDYQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D + QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ +H D+VH DLKP+N+LL S+ +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP D+W+ GV+ Y++L G PF D+ + + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
A + I +L P R TA++ LKHPW+ Q S ++ +E
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 289
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 179 bits (453), Expect = 5e-45
Identities = 95/285 (33%), Positives = 153/285 (53%), Gaps = 6/285 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+KK S +E+AAK + ++ ++ E + L
Sbjct: 10 FTDDYQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D + QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ +H D+VH DLKP+N+LL S+ +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP D+W+ GV+ Y++L G PF D+ + + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALE 338
A + I +L P R TA++ LKHPW+ Q S ++ +E
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 289
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 178 bits (451), Expect = 9e-45
Identities = 96/272 (35%), Positives = 147/272 (54%), Gaps = 6/272 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+K +G+E+AAK + ++ ++ E + L
Sbjct: 10 FTDEYQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D ++QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ H +VH DLKP+N+LL S+S +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP DMW+ GV+ Y++L G PF D+ + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
A D I +L P R TA E LKHPW+ Q S
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWICQRS 276
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 178 bits (451), Expect = 9e-45
Identities = 96/272 (35%), Positives = 147/272 (54%), Gaps = 6/272 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+K +G+E+AAK + ++ ++ E + L
Sbjct: 10 FTDEYQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D ++QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ H +VH DLKP+N+LL S+S +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP DMW+ GV+ Y++L G PF D+ + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
A D I +L P R TA E LKHPW+ Q S
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWICQRS 276
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 178 bits (451), Expect = 9e-45
Identities = 96/272 (35%), Positives = 147/272 (54%), Gaps = 6/272 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+K +G+E+AAK + ++ ++ E + L
Sbjct: 10 FTDEYQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D ++QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ H +VH DLKP+N+LL S+S +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP DMW+ GV+ Y++L G PF D+ + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
A D I +L P R TA E LKHPW+ Q S
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWICQRS 276
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 178 bits (451), Expect = 9e-45
Identities = 96/272 (35%), Positives = 147/272 (54%), Gaps = 6/272 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+K +G+E+AAK + ++ ++ E + L
Sbjct: 10 FTDEYQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D ++QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ H +VH DLKP+N+LL S+S +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP DMW+ GV+ Y++L G PF D+ + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
A D I +L P R TA E LKHPW+ Q S
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWICQRS 276
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 178 bits (451), Expect = 9e-45
Identities = 96/272 (35%), Positives = 147/272 (54%), Gaps = 6/272 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+K +G+E+AAK + ++ ++ E + L
Sbjct: 10 FTDEYQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D ++QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ H +VH DLKP+N+LL S+S +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP DMW+ GV+ Y++L G PF D+ + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
A D I +L P R TA E LKHPW+ Q S
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWICQRS 276
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 178 bits (451), Expect = 9e-45
Identities = 96/272 (35%), Positives = 147/272 (54%), Gaps = 6/272 (2%)
Query: 55 FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLEL 114
F D Y L ELG+G F+VVR+C+K +G+E+AAK + ++ ++ E + L
Sbjct: 10 FTDEYQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 115 AQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGV 174
+ +P ++ LH+ LV + GGE+F+ VA E + E D ++QILE V
Sbjct: 68 LK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESV 124
Query: 175 HFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELR-EIMGTPEYVAPE 233
+ H +VH DLKP+N+LL S+S +K+ DFGL+ ++ ++ GTP Y++PE
Sbjct: 125 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 184
Query: 234 ILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSES 293
+L DP DMW+ GV+ Y++L G PF D+ + I + E+D ++
Sbjct: 185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 294 AVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
A D I +L P R TA E LKHPW+ Q S
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWICQRS 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,864,699
Number of Sequences: 37866
Number of extensions: 832095
Number of successful extensions: 8840
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 682
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 6043
Number of HSP's gapped (non-prelim): 1343
length of query: 414
length of database: 18,247,518
effective HSP length: 105
effective length of query: 309
effective length of database: 14,271,588
effective search space: 4409920692
effective search space used: 4409920692
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.