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Search of human proteins with 14251205
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]
(390 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens] 784 0.0
gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens] 487 e-138
gi|194018562 histamine receptor H3 [Homo sapiens] 266 3e-71
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 144 1e-34
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 135 6e-32
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 133 3e-31
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 131 9e-31
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 130 2e-30
gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens] 129 6e-30
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 128 1e-29
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 126 4e-29
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 126 4e-29
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 126 4e-29
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 126 4e-29
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 126 4e-29
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 124 1e-28
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 117 2e-26
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 112 7e-25
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 110 2e-24
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 108 6e-24
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 108 8e-24
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 108 8e-24
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23
>gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]
Length = 390
Score = 784 bits (2024), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
Query: 61 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
Sbjct: 61 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120
Query: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 180
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
Sbjct: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 180
Query: 181 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 240
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
Sbjct: 181 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 240
Query: 241 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 300
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
Sbjct: 241 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 300
Query: 301 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 360
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
Sbjct: 301 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 360
Query: 361 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
Sbjct: 361 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390
>gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens]
Length = 302
Score = 487 bits (1253), Expect = e-138
Identities = 249/293 (84%), Positives = 258/293 (88%), Gaps = 16/293 (5%)
Query: 114 LSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVN----------------GPMILVSESW 157
LS+S V+ + V + L A+ +LAF+V+ +VSESW
Sbjct: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVVSESW 69
Query: 158 KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT 217
KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT
Sbjct: 70 KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT 129
Query: 218 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG 277
AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG
Sbjct: 130 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG 189
Query: 278 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 337
SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS
Sbjct: 190 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 249
Query: 338 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390
VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
Sbjct: 250 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 302
Score = 124 bits (311), Expect = 1e-28
Identities = 64/64 (100%), Positives = 64/64 (100%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
Query: 61 DFFV 64
DFFV
Sbjct: 61 DFFV 64
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 266 bits (679), Expect = 3e-71
Identities = 160/416 (38%), Positives = 215/416 (51%), Gaps = 63/416 (15%)
Query: 11 SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP 70
S + LA M+L+ A +LGNALV+LAFV D +LR ++++F LNLAISDF VG IP
Sbjct: 30 SAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIP 89
Query: 71 LYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGV 129
LY+P+ L W FG+ +C WL DYLLCT+S +NIVLISYDR+LSV+ AVSYR Q
Sbjct: 90 LYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDT 149
Query: 130 LKIVTLMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVI 185
+ V M+ VWVLAFL+ GP IL E S C FF WY L S LEF
Sbjct: 150 RRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFT 209
Query: 186 PVILVAYFNMNIY------------------------------------WSLWKRDHLSR 209
P + V +FN++IY W W++ H
Sbjct: 210 PFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEA 269
Query: 210 CQSH--------PGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261
H G A + + G G ++S S S S+ S R SL
Sbjct: 270 MPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSS-------SRGTERPRSLKR 322
Query: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321
S+ +S ++ +M SQS + + L R R++AKSLA+++ +F +CWAPY+L
Sbjct: 323 GSKPSASSASLEKRMKMVSQSFT------QRFRLSRDRKVAKSLAVIVSIFGLCWAPYTL 376
Query: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK 377
I+ + P WY +FWL W NS VNP+LYPLCH F++AF K+ C +K
Sbjct: 377 LMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQK 431
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 144 bits (363), Expect = 1e-34
Identities = 101/374 (27%), Positives = 181/374 (48%), Gaps = 49/374 (13%)
Query: 4 TNSTI-NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDF 62
+NST+ L ++ +++ + ++GN LVIL+ +++LR ++YF +NLA++D
Sbjct: 33 SNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADL 92
Query: 63 FVGVISIPLYIP-HTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVS 121
+ +P L W G+ C W D L CTAS+ ++ IS DRY+ V ++
Sbjct: 93 LLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQ 152
Query: 122 YRTQHTGVLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSECEPGFFSEWYILAITSF 180
Y T T K + +++VWVL+ +++ GP++ E ++ EC G E + +S
Sbjct: 153 YPTLVTR-RKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKEC--GVTEEPFYALFSSL 209
Query: 181 LEFVIP--VILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSL 238
F IP VILV Y C+ + + N+ + +
Sbjct: 210 GSFYIPLAVILVMY-----------------CRVYIVAKRTTKNL-------EAGVMKEM 245
Query: 239 SASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRA 298
S S E+ HS+ + ++ ++IA K+ FS R
Sbjct: 246 SNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFS----------------RE 289
Query: 299 RRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLY 358
++ AK+L I++G+F +CW P+ + + S +S+ P +V +++ FWL +FNS +NP++Y
Sbjct: 290 KKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAV-FKVVFWLGYFNSCLNPIIY 348
Query: 359 PLCHKRFQKAFLKI 372
P K F++AF++I
Sbjct: 349 PCSSKEFKRAFVRI 362
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 135 bits (340), Expect = 6e-32
Identities = 91/365 (24%), Positives = 176/365 (48%), Gaps = 29/365 (7%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP 74
+++LA +S++ A +L NA V+ ++ + L ++Y +LA +D V ++ +P+ I
Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
Query: 75 HTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIV 133
+T+ W+FG+ +C WL++D CTAS+ ++ +I+ DRY ++++A+ Y + T
Sbjct: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAG-HAA 156
Query: 134 TLMVAVWVLAFLVNGPMILVSES-WKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAY 192
T++ VW ++ ++ P + ++ ++E S+C Y + T F IP +L+
Sbjct: 157 TMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCG-AFYIPSVLLII 215
Query: 193 FNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSER 252
IY + R+ + S G ++++ S L S S S H
Sbjct: 216 LYGRIYRA--ARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNS---------SLHEGH 264
Query: 253 QRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVF 312
S +F + K+ +DS +R+ + R R+ K L I+LG F
Sbjct: 265 SHSAGSPLFFNHVKI------------KLADSAL--ERKRISAARERKATKILGIILGAF 310
Query: 313 AVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
+CW P+ + ++VL + + WL + NS +NP++Y + ++ F++AF KI
Sbjct: 311 IICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKI 370
Query: 373 FCIKK 377
+K
Sbjct: 371 VPFRK 375
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 133 bits (334), Expect = 3e-31
Identities = 95/369 (25%), Positives = 182/369 (49%), Gaps = 35/369 (9%)
Query: 12 LSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPL 71
+ +++ ++ +S +A N+LVI A +V + L H ++Y +LA++DF V V+ +P
Sbjct: 20 MPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF 79
Query: 72 YIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSY---RT-QH 126
I + + E W G+ +C WL+ D CT S+ ++ I+ DRY ++++AV Y RT +H
Sbjct: 80 SIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH 139
Query: 127 TGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEG-SECEPGFFSEWYILA--ITSFLEF 183
G+ ++ VW+++ ++ P + W+ +G S + +I++ ++F F
Sbjct: 140 AGI-----MITIVWIISVFISMPPLF----WRHQGTSRDDECIIKHDHIVSTIYSTFGAF 190
Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTE 243
IP+ L+ IY + H + +S I G++ ++
Sbjct: 191 YIPLALILILYYKIYRAAKTLYHKRQ----------ASRIAKEEVNGQVLLESGEKSTKS 240
Query: 244 VPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAK 303
V S+ E+ S F K++S T+ S F S +R+ + R R+ A
Sbjct: 241 VSTSYVLEKSLSDPSTDFD---KIHS-TVRSLRSEFKHEKS---WRRQKISGTRERKAAT 293
Query: 304 SLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHK 363
+L ++LG F +CW P+ + +V++ + + +A WL + NS +NPL+Y + ++
Sbjct: 294 TLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLA-WLGYLNSLINPLIYTIFNE 352
Query: 364 RFQKAFLKI 372
F+KAF K+
Sbjct: 353 DFKKAFQKL 361
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 131 bits (330), Expect = 9e-31
Identities = 94/376 (25%), Positives = 178/376 (47%), Gaps = 39/376 (10%)
Query: 9 NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVIS 68
++SL +V L ++L+ A L NA VI + L ++Y +LA++D V ++
Sbjct: 43 SISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILV 102
Query: 69 IPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHT 127
+P+ +T+ W G+ +C FWL++D CTAS+ ++ +I+ DRY ++++AV Y + T
Sbjct: 103 MPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRT 162
Query: 128 GVLKIVTLMVA-VWVLAFLVNGPMILVSES-WKDEGSECEPGFFSEWYILAITSFLEFVI 185
K +M+A VWV + ++ P ++ ++E SEC Y + T +
Sbjct: 163 P--KRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFP 220
Query: 186 PVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVP 245
++L+A +Y ++ + P T G+ +R L +
Sbjct: 221 TLLLIA-----LYGRIYVEARSRILKQTPNRT------------GKRLTRAQLITDSPGS 263
Query: 246 ASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSL 305
S + R + S + + N + ++ S AL +++ + R R+ K+L
Sbjct: 264 TSSVTSINSRVPDVPSESGSPVYVNQVKVRV-------SDALLEKKKLMAARERKATKTL 316
Query: 306 AILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAF-----WLQWFNSFVNPLLYPL 360
I+LG F VCW P+ + ++V+ A W+ +A WL + NS +NP++Y +
Sbjct: 317 GIILGAFIVCWLPFFIISLVMPICKDA-----CWFHLAIFDFFTWLGYLNSLINPIIYTM 371
Query: 361 CHKRFQKAFLKIFCIK 376
++ F++AF K+ K
Sbjct: 372 SNEDFKQAFHKLIRFK 387
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 130 bits (328), Expect = 2e-30
Identities = 99/353 (28%), Positives = 164/353 (46%), Gaps = 43/353 (12%)
Query: 24 LVAFAIML--GNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP-HTLFEW 80
L AF +M GN LVIL+ +++L+ ++YF +NLA++D + +P L W
Sbjct: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162
Query: 81 DFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVW 140
FG+ C W D L CTAS+ ++ IS DRY+ V +++ Y T K ++ +W
Sbjct: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMT-ERKAAAILALLW 221
Query: 141 VLAFLVN-GPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYW 199
V+A +V+ GP++ E + C G E +S F +P+ ++ +Y
Sbjct: 222 VVALVVSVGPLLGWKEPVPPDERFC--GITEEAGYAVFSSVCSFYLPMAVIVVMYCRVY- 278
Query: 200 SLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSL 259
++R S+ RSL A + SE R
Sbjct: 279 ------VVAR-----------------------STTRSLEAGVKRERGKASEVVLRIHCR 309
Query: 260 MFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPY 319
++ ++K +F S SV L ++ R ++ AK+LAI++GVF +CW P+
Sbjct: 310 GAATGADGAHGMRSAKGHTFRSSLSVRL-----LKFSREKKAAKTLAIVVGVFVLCWFPF 364
Query: 320 SLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
F + L P +++ FWL +FNS VNPL+YP + F++AFL++
Sbjct: 365 -FFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRL 416
>gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens]
Length = 67
Score = 129 bits (323), Expect = 6e-30
Identities = 66/67 (98%), Positives = 67/67 (100%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
Query: 61 DFFVGVI 67
DFFVGV+
Sbjct: 61 DFFVGVL 67
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 128 bits (321), Expect = 1e-29
Identities = 101/395 (25%), Positives = 182/395 (46%), Gaps = 62/395 (15%)
Query: 19 AFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP-HTL 77
A ++L+ I+ GN LV +A +K L+ ++Y ++LA++D V + +P + +
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 78 FEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMV 137
EW F + C ++T D ++CTAS+ N+ IS DRY +V+ + Y T+++ ++ ++
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 138 AVWVLAFLVNGPMIL-VSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMN 196
VWVL+F ++ P++ ++ + ++E P F + +S + F +P I+ +
Sbjct: 158 IVWVLSFTISCPLLFGLNNADQNECIIANPAF------VVYSSIVSFYVPFIVTLLVYIK 211
Query: 197 IYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRL------SSRRSLSASTEVPASFHS 250
IY L +R V++ +FR L ++RR+ E+ +S
Sbjct: 212 IYIVLRRR-----------RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSP 260
Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVAL-----HQREHVELL--------- 296
+ R S + S + S G S DS A H ++H ++
Sbjct: 261 PERTRYSPIPPSHHQLTLPD--PSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMP 318
Query: 297 -------------------RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 337
+ ++ + LAI+LGVF +CW P+ T +L+ + P
Sbjct: 319 NGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF-FITHILNIHCDCNIP-P 376
Query: 338 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
V Y WL + NS VNP++Y + F+KAFLKI
Sbjct: 377 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKI 411
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 126 bits (316), Expect = 4e-29
Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)
Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
+++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193
Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
+P+ ++ +Y + RG S + S S
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230
Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
+V H + S M S++TK + SV L ++ R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271
Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330
Query: 363 KRFQKAF---LKIFCI 375
+ F+KAF L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 126 bits (316), Expect = 4e-29
Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)
Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
+++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193
Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
+P+ ++ +Y + RG S + S S
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230
Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
+V H + S M S++TK + SV L ++ R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271
Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330
Query: 363 KRFQKAF---LKIFCI 375
+ F+KAF L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 126 bits (316), Expect = 4e-29
Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)
Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
+++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193
Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
+P+ ++ +Y + RG S + S S
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230
Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
+V H + S M S++TK + SV L ++ R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271
Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330
Query: 363 KRFQKAF---LKIFCI 375
+ F+KAF L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 126 bits (316), Expect = 4e-29
Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)
Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
+++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + +
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80
Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T
Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193
Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
+P+ ++ +Y + RG S + S S
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230
Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
+V H + S M S++TK + SV L ++ R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271
Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330
Query: 363 KRFQKAF---LKIFCI 375
+ F+KAF L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 126 bits (316), Expect = 4e-29
Identities = 103/362 (28%), Positives = 172/362 (47%), Gaps = 23/362 (6%)
Query: 28 AIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP--LYIPHTLFEWDFGKE 85
AI+ GN LV +A + ++ L+ ++Y ++LA++D V + +P +Y+ T W+F +
Sbjct: 42 AIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRI 101
Query: 86 ICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYR--TQHTGVLKIVTLMVAVWVLA 143
C ++T D ++CTAS+ N+ IS DRY +V V Y+ T + ++ ++ AVWVLA
Sbjct: 102 CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLA 161
Query: 144 FLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSL 201
F V+ P++ + D S P F Y ++ +L F + V++ A + +
Sbjct: 162 FAVSCPLLFGFNTTGDPTVCSISNPDFVI--YSSVVSFYLPFGVTVLVYARIYVVLKQRR 219
Query: 202 WKR---DHLSRCQS-HPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSER----- 252
KR S+C S PG + L S+ T + ER
Sbjct: 220 RKRILTRQNSQCNSVRPGFP--QQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELK 277
Query: 253 --QRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLG 310
++ ++SL + K++ G S S + Q V LR ++ + +AI+LG
Sbjct: 278 REEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVP-LREKKATQMVAIVLG 336
Query: 311 VFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFL 370
F VCW P+ L T VL+ + Y WL + NS +NP++Y + F+KAFL
Sbjct: 337 AFIVCWLPFFL-THVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395
Query: 371 KI 372
KI
Sbjct: 396 KI 397
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 124 bits (312), Expect = 1e-28
Identities = 99/351 (28%), Positives = 164/351 (46%), Gaps = 34/351 (9%)
Query: 28 AIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP--LYIPHTLFEWDFGKE 85
AI+ GN LV +A + ++ L+ ++Y ++LA++D V + +P +Y+ T W+F +
Sbjct: 42 AIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRI 101
Query: 86 ICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYR--TQHTGVLKIVTLMVAVWVLA 143
C ++T D ++CTAS+ N+ IS DRY +V V Y+ T + ++ ++ AVWVLA
Sbjct: 102 CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLA 161
Query: 144 FLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSL 201
F V+ P++ + D S P F Y ++ +L F + V++ A IY L
Sbjct: 162 FAVSCPLLFGFNTTGDPTVCSISNPDFVI--YSSVVSFYLPFGVTVLVYA----RIYVVL 215
Query: 202 WKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261
+R + ++ C S R T P H E +R S
Sbjct: 216 KQR-------RRKRILTRQNSQCN-------SVRPGFPQQTLSPDPAHLELKRYYS---I 258
Query: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321
T + + G + + R + LR ++ + +AI+LG F VCW P+ L
Sbjct: 259 CQDTALGGPGFQERGGELKREEKT----RNSLMPLREKKATQMVAIVLGAFIVCWLPFFL 314
Query: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
T VL+ + Y WL + NS +NP++Y + F+KAFLKI
Sbjct: 315 -THVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKI 364
>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
Length = 590
Score = 117 bits (292), Expect = 2e-26
Identities = 83/274 (30%), Positives = 135/274 (49%), Gaps = 11/274 (4%)
Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPH 75
V +AF ++A ++GN LVI++F V+K L+ ++YF L+LA +D +GVIS+ L+ +
Sbjct: 69 VFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTY 128
Query: 76 TLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVT 134
+ W G C WL DY+ ASV N+++IS+DRY S++ ++YR + T V
Sbjct: 129 IIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVM 188
Query: 135 LMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVIPVILV 190
+ +A WV++F++ P IL + + + + EC F SE I T+ F +PV ++
Sbjct: 189 IGLA-WVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIM 247
Query: 191 AYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHS 250
+YW ++K R + GL A + +F S RS S+ S
Sbjct: 248 TI----LYWRIYKETE-KRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDS 284
+R+ F TK + S SDS
Sbjct: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDS 336
Score = 67.8 bits (164), Expect = 2e-11
Identities = 44/177 (24%), Positives = 89/177 (50%), Gaps = 23/177 (12%)
Query: 231 RLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSN---------------TIASK 275
+L +++S+ P SF + +S++ + + +NS+ T+A +
Sbjct: 407 KLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKR 466
Query: 276 MGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGP 335
++S + +R+ + L++ ++ A++L+ +L F + W PY++ +V +F S P
Sbjct: 467 FALKTRSQ---ITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI-P 522
Query: 336 KSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIF---CIKKQPLPSQHSRSVS 389
K+ W + +WL + NS VNP+ Y LC+K F+ F + C KK+ Q+ + S
Sbjct: 523 KTFW-NLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQS 578
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 112 bits (279), Expect = 7e-25
Identities = 89/363 (24%), Positives = 162/363 (44%), Gaps = 58/363 (15%)
Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFL-NLAISDFFVGVISIPLYIP 74
+TL F+ FA L ++LA ++ HR + + ++A+SD V + +PL +
Sbjct: 44 LTLLGFLVAATFAWNL----LVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLV 99
Query: 75 HTLF--EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKI 132
H L W G+ +C W+ D L CTAS++N+ I+ DRY S++ + Y T T
Sbjct: 100 HELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVS 158
Query: 133 VTLMVAVWVLAFLVNGPMILV--SESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILV 190
++ W L+ +++ +L E++ + EC+ + + + F +P+ +V
Sbjct: 159 NVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVG--AFYLPLCVV 216
Query: 191 AYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHS 250
+ +YW ++K + + R+ SR++ S S + +
Sbjct: 217 LF----VYWKIYK-----------------------AAKFRVGSRKTNSVS-PISEAVEV 248
Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLG 310
+ ++ ++F T+ +F Q+E +R A + IL+G
Sbjct: 249 KDSAKQPQMVF---------TVRHATVTFQPEGDTWREQKE-------QRAALMVGILIG 292
Query: 311 VFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFL 370
VF +CW P+ L T ++S S P ++W I WL + NSF NPL+Y +K + AF
Sbjct: 293 VFVLCWIPFFL-TELISPLCSCDIP-AIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
Query: 371 KIF 373
F
Sbjct: 351 NFF 353
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 110 bits (276), Expect = 2e-24
Identities = 96/395 (24%), Positives = 177/395 (44%), Gaps = 47/395 (11%)
Query: 2 PDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISD 61
P + S LS + M+L+ I+ GN LVI+A L+ ++ F ++LA +D
Sbjct: 45 PASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASAD 104
Query: 62 FFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120
+G++ +P ++ W++G C W + D L TAS+ + +I+ DRYL++++
Sbjct: 105 LVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPF 164
Query: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSE---------CEPGFFSE 171
Y++ T + L+ VW ++ LV+ IL+ W+ E E C +
Sbjct: 165 RYQSLLTRA-RARGLVCTVWAISALVSFLPILM-HWWRAESDEARRCYNDPKCCDFVTNR 222
Query: 172 WYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGR 231
Y +A +S + F +P+ ++A+ + ++ K+ + C F G
Sbjct: 223 AYAIA-SSVVSFYVPLCIMAFVYLRVFREAQKQ-------------VKKIDSCERRFLGG 268
Query: 232 LSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE 291
+ S S S VPA R ++ ++ T +N A K +
Sbjct: 269 PARPPSPSPS-PVPAPAPPPGPPRPAA---AAATAPLANGRAGK------------RRPS 312
Query: 292 HVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNS 351
+ LR ++ K+L I++GVF +CW P+ L +V +F+ + + WL + NS
Sbjct: 313 RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR--LFVFFNWLGYANS 370
Query: 352 FVNPLLYPLCHK-RFQKAFLKIFCIKKQPLPSQHS 385
NP++Y C F+KAF + C ++ +H+
Sbjct: 371 AFNPIIY--CRSPDFRKAFQGLLCCARRAARRRHA 403
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 108 bits (271), Expect = 6e-24
Identities = 92/394 (23%), Positives = 173/394 (43%), Gaps = 48/394 (12%)
Query: 24 LVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDF 82
L+ F ++ GN LV++A + + LR + F ++LA +D V + +P + + L W F
Sbjct: 61 LIVFTVV-GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYF 119
Query: 83 GKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVL 142
G+ C +L D L CT+S+ ++ IS DRY SV+ AV Y + T ++ +VAVW++
Sbjct: 120 GQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRT-PRRVKATIVAVWLI 178
Query: 143 AFLVNGPMILVSESWKDEGSECEPGFFSE-WYILAITSFLEFVIPVILVAYFNMNIYWSL 201
+ +++ P ++ D + + G E WYIL+ + F P +++ IY
Sbjct: 179 SAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILS-SCIGSFFAPCLIMGLVYARIYRVA 237
Query: 202 WKRDHLSRCQSHP----GLTAVSSNICGHSFRGRLSSRRSLSASTEVP--ASFHSERQRR 255
R + P G + + N G + + + + P +S +ER+RR
Sbjct: 238 KLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRR 297
Query: 256 KSSLMFSSRTK------------------------MNSNTIASKMGSFSQSDSVALH--- 288
+ +L R + + ++ G S++ S ++
Sbjct: 298 RGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFL 357
Query: 289 ----------QREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSV 338
R V R +R LA+++GVF +CW P+ + A
Sbjct: 358 SRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGP 417
Query: 339 WYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
++ FW+ + NS +NP++Y + ++ F+++F I
Sbjct: 418 LFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHI 451
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 108 bits (270), Expect = 8e-24
Identities = 96/383 (25%), Positives = 168/383 (43%), Gaps = 42/383 (10%)
Query: 4 TNSTINLSLSTRVT-----LAFFMSLVAFAIM--LGNALVILAFVVDKNLRHRSSYFFLN 56
TN T S++ R + M+LV + L N VI+A K L ++Y +
Sbjct: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63
Query: 57 LAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLS 115
LA++D V V+ +PL I + + + W G +C WL+ D CT S+ ++ +I+ DRY +
Sbjct: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123
Query: 116 VSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYIL 175
++NA+ Y + T + +++ VW ++ ++ P + + + + I
Sbjct: 124 ITNAIEYARKRT-AKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIY 182
Query: 176 AITSFL-EFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS 234
I S L F IP+ L+ IY H ++ ++ R SS
Sbjct: 183 TIYSTLGAFYIPLTLILILYYRIY-------HAAK----------------SLYQKRGSS 219
Query: 235 RRSLSASTEVPASFHSERQRRK---SSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE 291
R + ST+ SF S + + S S T AS +D +R+
Sbjct: 220 RHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQ 279
Query: 292 HVELLRARRLAKSLAILLGVFAVCWAPYSLFTIV--LSFYSSATGPKSVWYRIAFWLQWF 349
+ R R+ A+ L ++LG F + W P+ + ++ LS Y+ ++ WL +
Sbjct: 280 QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVAD----FLTWLGYV 335
Query: 350 NSFVNPLLYPLCHKRFQKAFLKI 372
NS +NPLLY ++ F+ AF K+
Sbjct: 336 NSLINPLLYTSFNEDFKLAFKKL 358
>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
Length = 532
Score = 108 bits (270), Expect = 8e-24
Identities = 79/265 (29%), Positives = 133/265 (50%), Gaps = 12/265 (4%)
Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPH 75
+T+A ++V+ ++GN LV+++F V+ L+ ++Y+ L+LA +D +G+ S+ LY +
Sbjct: 31 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90
Query: 76 TLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVT 134
L W G C WL DY+ ASV N+++IS+DRY S++ ++YR + T K
Sbjct: 91 ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP--KRAG 148
Query: 135 LMVAV-WVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVIPVIL 189
+M+ + W+++F++ P IL + + + EC+ F SE I T+ F IPV +
Sbjct: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSV 208
Query: 190 VAYFNMNIYWSLWKR-DHLSRCQSHPGLTAVSSNICGHS--FRGRLSSRRSLSASTE-VP 245
+ IY KR L+ Q +T H FR L R A E
Sbjct: 209 MTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQ 268
Query: 246 ASFHSERQRRKSSLMFSSRTKMNSN 270
AS+ S R+ ++ S T ++N
Sbjct: 269 ASWSSSRRSTSTTGKPSQATGPSAN 293
Score = 64.7 bits (156), Expect = 1e-10
Identities = 28/81 (34%), Positives = 52/81 (64%), Gaps = 2/81 (2%)
Query: 289 QREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQW 348
+R+ V L++ R+ A++L+ +L F + W PY++ +V +F P ++W+ + +WL +
Sbjct: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCV-PVTLWH-LGYWLCY 485
Query: 349 FNSFVNPLLYPLCHKRFQKAF 369
NS VNP+ Y LC++ F+K F
Sbjct: 486 VNSTVNPICYALCNRTFRKTF 506
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 105 bits (262), Expect = 7e-23
Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)
Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
+N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA
Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
+D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+
Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182
Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
+ T+ F +PVI++ +YW H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438
Query: 357 LYPLCHKRFQKAF 369
Y LC+ F+K F
Sbjct: 439 CYALCNATFKKTF 451
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,274,926
Number of Sequences: 37866
Number of extensions: 523069
Number of successful extensions: 4315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 380
Number of HSP's that attempted gapping in prelim test: 2995
Number of HSP's gapped (non-prelim): 1119
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.