BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens] (390 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens] 784 0.0 gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens] 487 e-138 gi|194018562 histamine receptor H3 [Homo sapiens] 266 3e-71 gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 144 1e-34 gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 135 6e-32 gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 133 3e-31 gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 131 9e-31 gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 130 2e-30 gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens] 129 6e-30 gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 128 1e-29 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 126 4e-29 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 126 4e-29 gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 126 4e-29 gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 126 4e-29 gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 126 4e-29 gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 124 1e-28 gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 117 2e-26 gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 112 7e-25 gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 110 2e-24 gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 108 6e-24 gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 108 8e-24 gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 108 8e-24 gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 105 7e-23 >gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens] Length = 390 Score = 784 bits (2024), Expect = 0.0 Identities = 390/390 (100%), Positives = 390/390 (100%) Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60 Query: 61 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV Sbjct: 61 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120 Query: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 180 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF Sbjct: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 180 Query: 181 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 240 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA Sbjct: 181 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 240 Query: 241 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 300 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR Sbjct: 241 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 300 Query: 301 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 360 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL Sbjct: 301 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 360 Query: 361 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS Sbjct: 361 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390 >gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens] Length = 302 Score = 487 bits (1253), Expect = e-138 Identities = 249/293 (84%), Positives = 258/293 (88%), Gaps = 16/293 (5%) Query: 114 LSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVN----------------GPMILVSESW 157 LS+S V+ + V + L A+ +LAF+V+ +VSESW Sbjct: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVVSESW 69 Query: 158 KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT 217 KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT Sbjct: 70 KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT 129 Query: 218 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG 277 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG Sbjct: 130 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG 189 Query: 278 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 337 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS Sbjct: 190 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 249 Query: 338 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS Sbjct: 250 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 302 Score = 124 bits (311), Expect = 1e-28 Identities = 64/64 (100%), Positives = 64/64 (100%) Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60 Query: 61 DFFV 64 DFFV Sbjct: 61 DFFV 64 >gi|194018562 histamine receptor H3 [Homo sapiens] Length = 445 Score = 266 bits (679), Expect = 3e-71 Identities = 160/416 (38%), Positives = 215/416 (51%), Gaps = 63/416 (15%) Query: 11 SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP 70 S + LA M+L+ A +LGNALV+LAFV D +LR ++++F LNLAISDF VG IP Sbjct: 30 SAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIP 89 Query: 71 LYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGV 129 LY+P+ L W FG+ +C WL DYLLCT+S +NIVLISYDR+LSV+ AVSYR Q Sbjct: 90 LYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDT 149 Query: 130 LKIVTLMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVI 185 + V M+ VWVLAFL+ GP IL E S C FF WY L S LEF Sbjct: 150 RRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFT 209 Query: 186 PVILVAYFNMNIY------------------------------------WSLWKRDHLSR 209 P + V +FN++IY W W++ H Sbjct: 210 PFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEA 269 Query: 210 CQSH--------PGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261 H G A + + G G ++S S S S+ S R SL Sbjct: 270 MPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSS-------SRGTERPRSLKR 322 Query: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321 S+ +S ++ +M SQS + + L R R++AKSLA+++ +F +CWAPY+L Sbjct: 323 GSKPSASSASLEKRMKMVSQSFT------QRFRLSRDRKVAKSLAVIVSIFGLCWAPYTL 376 Query: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK 377 I+ + P WY +FWL W NS VNP+LYPLCH F++AF K+ C +K Sbjct: 377 LMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQK 431 >gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] Length = 520 Score = 144 bits (363), Expect = 1e-34 Identities = 101/374 (27%), Positives = 181/374 (48%), Gaps = 49/374 (13%) Query: 4 TNSTI-NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDF 62 +NST+ L ++ +++ + ++GN LVIL+ +++LR ++YF +NLA++D Sbjct: 33 SNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADL 92 Query: 63 FVGVISIPLYIP-HTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVS 121 + +P L W G+ C W D L CTAS+ ++ IS DRY+ V ++ Sbjct: 93 LLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQ 152 Query: 122 YRTQHTGVLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSECEPGFFSEWYILAITSF 180 Y T T K + +++VWVL+ +++ GP++ E ++ EC G E + +S Sbjct: 153 YPTLVTR-RKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKEC--GVTEEPFYALFSSL 209 Query: 181 LEFVIP--VILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSL 238 F IP VILV Y C+ + + N+ + + Sbjct: 210 GSFYIPLAVILVMY-----------------CRVYIVAKRTTKNL-------EAGVMKEM 245 Query: 239 SASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRA 298 S S E+ HS+ + ++ ++IA K+ FS R Sbjct: 246 SNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFS----------------RE 289 Query: 299 RRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLY 358 ++ AK+L I++G+F +CW P+ + + S +S+ P +V +++ FWL +FNS +NP++Y Sbjct: 290 KKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAV-FKVVFWLGYFNSCLNPIIY 348 Query: 359 PLCHKRFQKAFLKI 372 P K F++AF++I Sbjct: 349 PCSSKEFKRAFVRI 362 >gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sapiens] Length = 377 Score = 135 bits (340), Expect = 6e-32 Identities = 91/365 (24%), Positives = 176/365 (48%), Gaps = 29/365 (7%) Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP 74 +++LA +S++ A +L NA V+ ++ + L ++Y +LA +D V ++ +P+ I Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97 Query: 75 HTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIV 133 +T+ W+FG+ +C WL++D CTAS+ ++ +I+ DRY ++++A+ Y + T Sbjct: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAG-HAA 156 Query: 134 TLMVAVWVLAFLVNGPMILVSES-WKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAY 192 T++ VW ++ ++ P + ++ ++E S+C Y + T F IP +L+ Sbjct: 157 TMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCG-AFYIPSVLLII 215 Query: 193 FNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSER 252 IY + R+ + S G ++++ S L S S S H Sbjct: 216 LYGRIYRA--ARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNS---------SLHEGH 264 Query: 253 QRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVF 312 S +F + K+ +DS +R+ + R R+ K L I+LG F Sbjct: 265 SHSAGSPLFFNHVKI------------KLADSAL--ERKRISAARERKATKILGIILGAF 310 Query: 313 AVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372 +CW P+ + ++VL + + WL + NS +NP++Y + ++ F++AF KI Sbjct: 311 IICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKI 370 Query: 373 FCIKK 377 +K Sbjct: 371 VPFRK 375 >gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sapiens] Length = 366 Score = 133 bits (334), Expect = 3e-31 Identities = 95/369 (25%), Positives = 182/369 (49%), Gaps = 35/369 (9%) Query: 12 LSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPL 71 + +++ ++ +S +A N+LVI A +V + L H ++Y +LA++DF V V+ +P Sbjct: 20 MPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF 79 Query: 72 YIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSY---RT-QH 126 I + + E W G+ +C WL+ D CT S+ ++ I+ DRY ++++AV Y RT +H Sbjct: 80 SIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH 139 Query: 127 TGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEG-SECEPGFFSEWYILA--ITSFLEF 183 G+ ++ VW+++ ++ P + W+ +G S + +I++ ++F F Sbjct: 140 AGI-----MITIVWIISVFISMPPLF----WRHQGTSRDDECIIKHDHIVSTIYSTFGAF 190 Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTE 243 IP+ L+ IY + H + +S I G++ ++ Sbjct: 191 YIPLALILILYYKIYRAAKTLYHKRQ----------ASRIAKEEVNGQVLLESGEKSTKS 240 Query: 244 VPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAK 303 V S+ E+ S F K++S T+ S F S +R+ + R R+ A Sbjct: 241 VSTSYVLEKSLSDPSTDFD---KIHS-TVRSLRSEFKHEKS---WRRQKISGTRERKAAT 293 Query: 304 SLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHK 363 +L ++LG F +CW P+ + +V++ + + +A WL + NS +NPL+Y + ++ Sbjct: 294 TLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLA-WLGYLNSLINPLIYTIFNE 352 Query: 364 RFQKAFLKI 372 F+KAF K+ Sbjct: 353 DFKKAFQKL 361 >gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sapiens] Length = 390 Score = 131 bits (330), Expect = 9e-31 Identities = 94/376 (25%), Positives = 178/376 (47%), Gaps = 39/376 (10%) Query: 9 NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVIS 68 ++SL +V L ++L+ A L NA VI + L ++Y +LA++D V ++ Sbjct: 43 SISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILV 102 Query: 69 IPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHT 127 +P+ +T+ W G+ +C FWL++D CTAS+ ++ +I+ DRY ++++AV Y + T Sbjct: 103 MPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRT 162 Query: 128 GVLKIVTLMVA-VWVLAFLVNGPMILVSES-WKDEGSECEPGFFSEWYILAITSFLEFVI 185 K +M+A VWV + ++ P ++ ++E SEC Y + T + Sbjct: 163 P--KRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFP 220 Query: 186 PVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVP 245 ++L+A +Y ++ + P T G+ +R L + Sbjct: 221 TLLLIA-----LYGRIYVEARSRILKQTPNRT------------GKRLTRAQLITDSPGS 263 Query: 246 ASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSL 305 S + R + S + + N + ++ S AL +++ + R R+ K+L Sbjct: 264 TSSVTSINSRVPDVPSESGSPVYVNQVKVRV-------SDALLEKKKLMAARERKATKTL 316 Query: 306 AILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAF-----WLQWFNSFVNPLLYPL 360 I+LG F VCW P+ + ++V+ A W+ +A WL + NS +NP++Y + Sbjct: 317 GIILGAFIVCWLPFFIISLVMPICKDA-----CWFHLAIFDFFTWLGYLNSLINPIIYTM 371 Query: 361 CHKRFQKAFLKIFCIK 376 ++ F++AF K+ K Sbjct: 372 SNEDFKQAFHKLIRFK 387 >gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] Length = 572 Score = 130 bits (328), Expect = 2e-30 Identities = 99/353 (28%), Positives = 164/353 (46%), Gaps = 43/353 (12%) Query: 24 LVAFAIML--GNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP-HTLFEW 80 L AF +M GN LVIL+ +++L+ ++YF +NLA++D + +P L W Sbjct: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162 Query: 81 DFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVW 140 FG+ C W D L CTAS+ ++ IS DRY+ V +++ Y T K ++ +W Sbjct: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMT-ERKAAAILALLW 221 Query: 141 VLAFLVN-GPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYW 199 V+A +V+ GP++ E + C G E +S F +P+ ++ +Y Sbjct: 222 VVALVVSVGPLLGWKEPVPPDERFC--GITEEAGYAVFSSVCSFYLPMAVIVVMYCRVY- 278 Query: 200 SLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSL 259 ++R S+ RSL A + SE R Sbjct: 279 ------VVAR-----------------------STTRSLEAGVKRERGKASEVVLRIHCR 309 Query: 260 MFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPY 319 ++ ++K +F S SV L ++ R ++ AK+LAI++GVF +CW P+ Sbjct: 310 GAATGADGAHGMRSAKGHTFRSSLSVRL-----LKFSREKKAAKTLAIVVGVFVLCWFPF 364 Query: 320 SLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372 F + L P +++ FWL +FNS VNPL+YP + F++AFL++ Sbjct: 365 -FFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRL 416 >gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens] Length = 67 Score = 129 bits (323), Expect = 6e-30 Identities = 66/67 (98%), Positives = 67/67 (100%) Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60 Query: 61 DFFVGVI 67 DFFVGV+ Sbjct: 61 DFFVGVL 67 >gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] Length = 414 Score = 128 bits (321), Expect = 1e-29 Identities = 101/395 (25%), Positives = 182/395 (46%), Gaps = 62/395 (15%) Query: 19 AFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP-HTL 77 A ++L+ I+ GN LV +A +K L+ ++Y ++LA++D V + +P + + Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97 Query: 78 FEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMV 137 EW F + C ++T D ++CTAS+ N+ IS DRY +V+ + Y T+++ ++ ++ Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157 Query: 138 AVWVLAFLVNGPMIL-VSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMN 196 VWVL+F ++ P++ ++ + ++E P F + +S + F +P I+ + Sbjct: 158 IVWVLSFTISCPLLFGLNNADQNECIIANPAF------VVYSSIVSFYVPFIVTLLVYIK 211 Query: 197 IYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRL------SSRRSLSASTEVPASFHS 250 IY L +R V++ +FR L ++RR+ E+ +S Sbjct: 212 IYIVLRRR-----------RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSP 260 Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVAL-----HQREHVELL--------- 296 + R S + S + S G S DS A H ++H ++ Sbjct: 261 PERTRYSPIPPSHHQLTLPD--PSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMP 318 Query: 297 -------------------RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 337 + ++ + LAI+LGVF +CW P+ T +L+ + P Sbjct: 319 NGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF-FITHILNIHCDCNIP-P 376 Query: 338 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372 V Y WL + NS VNP++Y + F+KAFLKI Sbjct: 377 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKI 411 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 126 bits (316), Expect = 4e-29 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%) Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69 +++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + + Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80 Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128 P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140 Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183 ++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193 Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242 +P+ ++ +Y + RG S + S S Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230 Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302 +V H + S M S++TK + SV L ++ R ++ A Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271 Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362 K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330 Query: 363 KRFQKAF---LKIFCI 375 + F+KAF L+I C+ Sbjct: 331 QEFKKAFQNVLRIQCL 346 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 126 bits (316), Expect = 4e-29 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%) Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69 +++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + + Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80 Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128 P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140 Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183 ++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193 Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242 +P+ ++ +Y + RG S + S S Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230 Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302 +V H + S M S++TK + SV L ++ R ++ A Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271 Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362 K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330 Query: 363 KRFQKAF---LKIFCI 375 + F+KAF L+I C+ Sbjct: 331 QEFKKAFQNVLRIQCL 346 >gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] Length = 475 Score = 126 bits (316), Expect = 4e-29 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%) Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69 +++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + + Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80 Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128 P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140 Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183 ++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193 Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242 +P+ ++ +Y + RG S + S S Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230 Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302 +V H + S M S++TK + SV L ++ R ++ A Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271 Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362 K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330 Query: 363 KRFQKAF---LKIFCI 375 + F+KAF L+I C+ Sbjct: 331 QEFKKAFQNVLRIQCL 346 >gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] Length = 429 Score = 126 bits (316), Expect = 4e-29 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%) Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69 +++S + L + + +LGN LVIL+ ++L + Y+ +NLA++D + + Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80 Query: 70 PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128 P I L W FG+ C W D L CTAS+ + +IS DRY+ VS + Y T T Sbjct: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140 Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183 ++ L+ VW L+ +++ GP+ + ++ + C EPG+ + ++ F Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193 Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242 +P+ ++ +Y + RG S + S S Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230 Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302 +V H + S M S++TK + SV L ++ R ++ A Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271 Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362 K+L I++G F +CW P+ L + SF+ P ++I FWL + NS +NP++YP Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330 Query: 363 KRFQKAF---LKIFCI 375 + F+KAF L+I C+ Sbjct: 331 QEFKKAFQNVLRIQCL 346 >gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] Length = 400 Score = 126 bits (316), Expect = 4e-29 Identities = 103/362 (28%), Positives = 172/362 (47%), Gaps = 23/362 (6%) Query: 28 AIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP--LYIPHTLFEWDFGKE 85 AI+ GN LV +A + ++ L+ ++Y ++LA++D V + +P +Y+ T W+F + Sbjct: 42 AIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRI 101 Query: 86 ICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYR--TQHTGVLKIVTLMVAVWVLA 143 C ++T D ++CTAS+ N+ IS DRY +V V Y+ T + ++ ++ AVWVLA Sbjct: 102 CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLA 161 Query: 144 FLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSL 201 F V+ P++ + D S P F Y ++ +L F + V++ A + + Sbjct: 162 FAVSCPLLFGFNTTGDPTVCSISNPDFVI--YSSVVSFYLPFGVTVLVYARIYVVLKQRR 219 Query: 202 WKR---DHLSRCQS-HPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSER----- 252 KR S+C S PG + L S+ T + ER Sbjct: 220 RKRILTRQNSQCNSVRPGFP--QQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELK 277 Query: 253 --QRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLG 310 ++ ++SL + K++ G S S + Q V LR ++ + +AI+LG Sbjct: 278 REEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVP-LREKKATQMVAIVLG 336 Query: 311 VFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFL 370 F VCW P+ L T VL+ + Y WL + NS +NP++Y + F+KAFL Sbjct: 337 AFIVCWLPFFL-THVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395 Query: 371 KI 372 KI Sbjct: 396 KI 397 >gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] Length = 367 Score = 124 bits (312), Expect = 1e-28 Identities = 99/351 (28%), Positives = 164/351 (46%), Gaps = 34/351 (9%) Query: 28 AIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP--LYIPHTLFEWDFGKE 85 AI+ GN LV +A + ++ L+ ++Y ++LA++D V + +P +Y+ T W+F + Sbjct: 42 AIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRI 101 Query: 86 ICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYR--TQHTGVLKIVTLMVAVWVLA 143 C ++T D ++CTAS+ N+ IS DRY +V V Y+ T + ++ ++ AVWVLA Sbjct: 102 CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLA 161 Query: 144 FLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSL 201 F V+ P++ + D S P F Y ++ +L F + V++ A IY L Sbjct: 162 FAVSCPLLFGFNTTGDPTVCSISNPDFVI--YSSVVSFYLPFGVTVLVYA----RIYVVL 215 Query: 202 WKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261 +R + ++ C S R T P H E +R S Sbjct: 216 KQR-------RRKRILTRQNSQCN-------SVRPGFPQQTLSPDPAHLELKRYYS---I 258 Query: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321 T + + G + + R + LR ++ + +AI+LG F VCW P+ L Sbjct: 259 CQDTALGGPGFQERGGELKREEKT----RNSLMPLREKKATQMVAIVLGAFIVCWLPFFL 314 Query: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372 T VL+ + Y WL + NS +NP++Y + F+KAFLKI Sbjct: 315 -THVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKI 364 >gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] Length = 590 Score = 117 bits (292), Expect = 2e-26 Identities = 83/274 (30%), Positives = 135/274 (49%), Gaps = 11/274 (4%) Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPH 75 V +AF ++A ++GN LVI++F V+K L+ ++YF L+LA +D +GVIS+ L+ + Sbjct: 69 VFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTY 128 Query: 76 TLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVT 134 + W G C WL DY+ ASV N+++IS+DRY S++ ++YR + T V Sbjct: 129 IIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVM 188 Query: 135 LMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVIPVILV 190 + +A WV++F++ P IL + + + + EC F SE I T+ F +PV ++ Sbjct: 189 IGLA-WVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIM 247 Query: 191 AYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHS 250 +YW ++K R + GL A + +F S RS S+ S Sbjct: 248 TI----LYWRIYKETE-KRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302 Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDS 284 +R+ F TK + S SDS Sbjct: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDS 336 Score = 67.8 bits (164), Expect = 2e-11 Identities = 44/177 (24%), Positives = 89/177 (50%), Gaps = 23/177 (12%) Query: 231 RLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSN---------------TIASK 275 +L +++S+ P SF + +S++ + + +NS+ T+A + Sbjct: 407 KLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKR 466 Query: 276 MGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGP 335 ++S + +R+ + L++ ++ A++L+ +L F + W PY++ +V +F S P Sbjct: 467 FALKTRSQ---ITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI-P 522 Query: 336 KSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIF---CIKKQPLPSQHSRSVS 389 K+ W + +WL + NS VNP+ Y LC+K F+ F + C KK+ Q+ + S Sbjct: 523 KTFW-NLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQS 578 >gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] Length = 357 Score = 112 bits (279), Expect = 7e-25 Identities = 89/363 (24%), Positives = 162/363 (44%), Gaps = 58/363 (15%) Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFL-NLAISDFFVGVISIPLYIP 74 +TL F+ FA L ++LA ++ HR + + ++A+SD V + +PL + Sbjct: 44 LTLLGFLVAATFAWNL----LVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLV 99 Query: 75 HTLF--EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKI 132 H L W G+ +C W+ D L CTAS++N+ I+ DRY S++ + Y T T Sbjct: 100 HELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVS 158 Query: 133 VTLMVAVWVLAFLVNGPMILV--SESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILV 190 ++ W L+ +++ +L E++ + EC+ + + + F +P+ +V Sbjct: 159 NVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVG--AFYLPLCVV 216 Query: 191 AYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHS 250 + +YW ++K + + R+ SR++ S S + + Sbjct: 217 LF----VYWKIYK-----------------------AAKFRVGSRKTNSVS-PISEAVEV 248 Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLG 310 + ++ ++F T+ +F Q+E +R A + IL+G Sbjct: 249 KDSAKQPQMVF---------TVRHATVTFQPEGDTWREQKE-------QRAALMVGILIG 292 Query: 311 VFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFL 370 VF +CW P+ L T ++S S P ++W I WL + NSF NPL+Y +K + AF Sbjct: 293 VFVLCWIPFFL-TELISPLCSCDIP-AIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350 Query: 371 KIF 373 F Sbjct: 351 NFF 353 >gi|4557265 beta-1-adrenergic receptor [Homo sapiens] Length = 477 Score = 110 bits (276), Expect = 2e-24 Identities = 96/395 (24%), Positives = 177/395 (44%), Gaps = 47/395 (11%) Query: 2 PDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISD 61 P + S LS + M+L+ I+ GN LVI+A L+ ++ F ++LA +D Sbjct: 45 PASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASAD 104 Query: 62 FFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120 +G++ +P ++ W++G C W + D L TAS+ + +I+ DRYL++++ Sbjct: 105 LVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPF 164 Query: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSE---------CEPGFFSE 171 Y++ T + L+ VW ++ LV+ IL+ W+ E E C + Sbjct: 165 RYQSLLTRA-RARGLVCTVWAISALVSFLPILM-HWWRAESDEARRCYNDPKCCDFVTNR 222 Query: 172 WYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGR 231 Y +A +S + F +P+ ++A+ + ++ K+ + C F G Sbjct: 223 AYAIA-SSVVSFYVPLCIMAFVYLRVFREAQKQ-------------VKKIDSCERRFLGG 268 Query: 232 LSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE 291 + S S S VPA R ++ ++ T +N A K + Sbjct: 269 PARPPSPSPS-PVPAPAPPPGPPRPAA---AAATAPLANGRAGK------------RRPS 312 Query: 292 HVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNS 351 + LR ++ K+L I++GVF +CW P+ L +V +F+ + + WL + NS Sbjct: 313 RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR--LFVFFNWLGYANS 370 Query: 352 FVNPLLYPLCHK-RFQKAFLKIFCIKKQPLPSQHS 385 NP++Y C F+KAF + C ++ +H+ Sbjct: 371 AFNPIIY--CRSPDFRKAFQGLLCCARRAARRRHA 403 >gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] Length = 462 Score = 108 bits (271), Expect = 6e-24 Identities = 92/394 (23%), Positives = 173/394 (43%), Gaps = 48/394 (12%) Query: 24 LVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDF 82 L+ F ++ GN LV++A + + LR + F ++LA +D V + +P + + L W F Sbjct: 61 LIVFTVV-GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYF 119 Query: 83 GKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVL 142 G+ C +L D L CT+S+ ++ IS DRY SV+ AV Y + T ++ +VAVW++ Sbjct: 120 GQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRT-PRRVKATIVAVWLI 178 Query: 143 AFLVNGPMILVSESWKDEGSECEPGFFSE-WYILAITSFLEFVIPVILVAYFNMNIYWSL 201 + +++ P ++ D + + G E WYIL+ + F P +++ IY Sbjct: 179 SAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILS-SCIGSFFAPCLIMGLVYARIYRVA 237 Query: 202 WKRDHLSRCQSHP----GLTAVSSNICGHSFRGRLSSRRSLSASTEVP--ASFHSERQRR 255 R + P G + + N G + + + + P +S +ER+RR Sbjct: 238 KLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRR 297 Query: 256 KSSLMFSSRTK------------------------MNSNTIASKMGSFSQSDSVALH--- 288 + +L R + + ++ G S++ S ++ Sbjct: 298 RGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFL 357 Query: 289 ----------QREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSV 338 R V R +R LA+++GVF +CW P+ + A Sbjct: 358 SRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGP 417 Query: 339 WYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372 ++ FW+ + NS +NP++Y + ++ F+++F I Sbjct: 418 LFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHI 451 >gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sapiens] Length = 365 Score = 108 bits (270), Expect = 8e-24 Identities = 96/383 (25%), Positives = 168/383 (43%), Gaps = 42/383 (10%) Query: 4 TNSTINLSLSTRVT-----LAFFMSLVAFAIM--LGNALVILAFVVDKNLRHRSSYFFLN 56 TN T S++ R + M+LV + L N VI+A K L ++Y + Sbjct: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63 Query: 57 LAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLS 115 LA++D V V+ +PL I + + + W G +C WL+ D CT S+ ++ +I+ DRY + Sbjct: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123 Query: 116 VSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYIL 175 ++NA+ Y + T + +++ VW ++ ++ P + + + + I Sbjct: 124 ITNAIEYARKRT-AKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIY 182 Query: 176 AITSFL-EFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS 234 I S L F IP+ L+ IY H ++ ++ R SS Sbjct: 183 TIYSTLGAFYIPLTLILILYYRIY-------HAAK----------------SLYQKRGSS 219 Query: 235 RRSLSASTEVPASFHSERQRRK---SSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE 291 R + ST+ SF S + + S S T AS +D +R+ Sbjct: 220 RHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQ 279 Query: 292 HVELLRARRLAKSLAILLGVFAVCWAPYSLFTIV--LSFYSSATGPKSVWYRIAFWLQWF 349 + R R+ A+ L ++LG F + W P+ + ++ LS Y+ ++ WL + Sbjct: 280 QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVAD----FLTWLGYV 335 Query: 350 NSFVNPLLYPLCHKRFQKAFLKI 372 NS +NPLLY ++ F+ AF K+ Sbjct: 336 NSLINPLLYTSFNEDFKLAFKKL 358 >gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] Length = 532 Score = 108 bits (270), Expect = 8e-24 Identities = 79/265 (29%), Positives = 133/265 (50%), Gaps = 12/265 (4%) Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPH 75 +T+A ++V+ ++GN LV+++F V+ L+ ++Y+ L+LA +D +G+ S+ LY + Sbjct: 31 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90 Query: 76 TLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVT 134 L W G C WL DY+ ASV N+++IS+DRY S++ ++YR + T K Sbjct: 91 ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP--KRAG 148 Query: 135 LMVAV-WVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVIPVIL 189 +M+ + W+++F++ P IL + + + EC+ F SE I T+ F IPV + Sbjct: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSV 208 Query: 190 VAYFNMNIYWSLWKR-DHLSRCQSHPGLTAVSSNICGHS--FRGRLSSRRSLSASTE-VP 245 + IY KR L+ Q +T H FR L R A E Sbjct: 209 MTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQ 268 Query: 246 ASFHSERQRRKSSLMFSSRTKMNSN 270 AS+ S R+ ++ S T ++N Sbjct: 269 ASWSSSRRSTSTTGKPSQATGPSAN 293 Score = 64.7 bits (156), Expect = 1e-10 Identities = 28/81 (34%), Positives = 52/81 (64%), Gaps = 2/81 (2%) Query: 289 QREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQW 348 +R+ V L++ R+ A++L+ +L F + W PY++ +V +F P ++W+ + +WL + Sbjct: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCV-PVTLWH-LGYWLCY 485 Query: 349 FNSFVNPLLYPLCHKRFQKAF 369 NS VNP+ Y LC++ F+K F Sbjct: 486 VNSTVNPICYALCNRTFRKTF 506 >gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 >gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 105 bits (262), Expect = 7e-23 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%) Query: 4 TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59 +N+++ L+ + F+ LVA ++ L GN LV+++ V+++L+ ++YF +LA Sbjct: 8 SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67 Query: 60 SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118 +D +GV S+ LY +T+ W G +C WL DY++ ASV N+++IS+DRY V+ Sbjct: 68 ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127 Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170 ++Y + T K+ +M+ A WVL+F++ P IL W+ E EC FFS Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182 Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209 + T+ F +PVI++ +YW H+SR Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211 Score = 56.6 bits (135), Expect = 4e-08 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%) Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356 R +++ +++ +L F + WAPY++ ++ +F + P +VW I +WL + NS +NP Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438 Query: 357 LYPLCHKRFQKAF 369 Y LC+ F+K F Sbjct: 439 CYALCNATFKKTF 451 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.136 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,274,926 Number of Sequences: 37866 Number of extensions: 523069 Number of successful extensions: 4315 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 268 Number of HSP's successfully gapped in prelim test: 380 Number of HSP's that attempted gapping in prelim test: 2995 Number of HSP's gapped (non-prelim): 1119 length of query: 390 length of database: 18,247,518 effective HSP length: 104 effective length of query: 286 effective length of database: 14,309,454 effective search space: 4092503844 effective search space used: 4092503844 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.