Guide to the Human Genome
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Search of human proteins with 14251205

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]
         (390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]            784   0.0  
gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens]           487   e-138
gi|194018562 histamine receptor H3 [Homo sapiens]                     266   3e-71
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                144   1e-34
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   135   6e-32
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   133   3e-31
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   131   9e-31
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                130   2e-30
gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens]           129   6e-30
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         128   1e-29
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    126   4e-29
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    126   4e-29
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    126   4e-29
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    126   4e-29
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             126   4e-29
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             124   1e-28
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]          117   2e-26
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]            112   7e-25
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  110   2e-24
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]               108   6e-24
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   108   8e-24
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]          108   8e-24
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]          105   7e-23
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]         105   7e-23

>gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]
          Length = 390

 Score =  784 bits (2024), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
           MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1   MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60

Query: 61  DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120
           DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
Sbjct: 61  DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120

Query: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 180
           SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
Sbjct: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 180

Query: 181 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 240
           LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
Sbjct: 181 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 240

Query: 241 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 300
           STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
Sbjct: 241 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 300

Query: 301 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 360
           LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
Sbjct: 301 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 360

Query: 361 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390
           CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
Sbjct: 361 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390


>gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens]
          Length = 302

 Score =  487 bits (1253), Expect = e-138
 Identities = 249/293 (84%), Positives = 258/293 (88%), Gaps = 16/293 (5%)

Query: 114 LSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVN----------------GPMILVSESW 157
           LS+S  V+     + V   + L  A+ +LAF+V+                    +VSESW
Sbjct: 10  LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVVSESW 69

Query: 158 KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT 217
           KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT
Sbjct: 70  KDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLT 129

Query: 218 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG 277
           AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG
Sbjct: 130 AVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMG 189

Query: 278 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 337
           SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS
Sbjct: 190 SFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 249

Query: 338 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 390
           VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
Sbjct: 250 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 302



 Score =  124 bits (311), Expect = 1e-28
 Identities = 64/64 (100%), Positives = 64/64 (100%)

Query: 1  MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
          MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1  MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60

Query: 61 DFFV 64
          DFFV
Sbjct: 61 DFFV 64


>gi|194018562 histamine receptor H3 [Homo sapiens]
          Length = 445

 Score =  266 bits (679), Expect = 3e-71
 Identities = 160/416 (38%), Positives = 215/416 (51%), Gaps = 63/416 (15%)

Query: 11  SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP 70
           S +    LA  M+L+  A +LGNALV+LAFV D +LR ++++F LNLAISDF VG   IP
Sbjct: 30  SAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIP 89

Query: 71  LYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGV 129
           LY+P+ L   W FG+ +C  WL  DYLLCT+S +NIVLISYDR+LSV+ AVSYR Q    
Sbjct: 90  LYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDT 149

Query: 130 LKIVTLMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVI 185
            + V  M+ VWVLAFL+ GP IL  E      S     C   FF  WY L   S LEF  
Sbjct: 150 RRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFT 209

Query: 186 PVILVAYFNMNIY------------------------------------WSLWKRDHLSR 209
           P + V +FN++IY                                    W  W++ H   
Sbjct: 210 PFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEA 269

Query: 210 CQSH--------PGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261
              H         G  A  + + G    G ++S  S S S+       S    R  SL  
Sbjct: 270 MPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSS-------SRGTERPRSLKR 322

Query: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321
            S+   +S ++  +M   SQS +      +   L R R++AKSLA+++ +F +CWAPY+L
Sbjct: 323 GSKPSASSASLEKRMKMVSQSFT------QRFRLSRDRKVAKSLAVIVSIFGLCWAPYTL 376

Query: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK 377
             I+ +       P   WY  +FWL W NS VNP+LYPLCH  F++AF K+ C +K
Sbjct: 377 LMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQK 431


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  144 bits (363), Expect = 1e-34
 Identities = 101/374 (27%), Positives = 181/374 (48%), Gaps = 49/374 (13%)

Query: 4   TNSTI-NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDF 62
           +NST+  L ++  +++   +       ++GN LVIL+   +++LR  ++YF +NLA++D 
Sbjct: 33  SNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADL 92

Query: 63  FVGVISIPLYIP-HTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVS 121
            +    +P       L  W  G+  C  W   D L CTAS+ ++  IS DRY+ V  ++ 
Sbjct: 93  LLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQ 152

Query: 122 YRTQHTGVLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSECEPGFFSEWYILAITSF 180
           Y T  T   K +  +++VWVL+ +++ GP++   E   ++  EC  G   E +    +S 
Sbjct: 153 YPTLVTR-RKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKEC--GVTEEPFYALFSSL 209

Query: 181 LEFVIP--VILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSL 238
             F IP  VILV Y                 C+ +      + N+            + +
Sbjct: 210 GSFYIPLAVILVMY-----------------CRVYIVAKRTTKNL-------EAGVMKEM 245

Query: 239 SASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRA 298
           S S E+    HS+     +     ++     ++IA K+  FS                R 
Sbjct: 246 SNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFS----------------RE 289

Query: 299 RRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLY 358
           ++ AK+L I++G+F +CW P+ +   + S +S+   P +V +++ FWL +FNS +NP++Y
Sbjct: 290 KKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAV-FKVVFWLGYFNSCLNPIIY 348

Query: 359 PLCHKRFQKAFLKI 372
           P   K F++AF++I
Sbjct: 349 PCSSKEFKRAFVRI 362


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  135 bits (340), Expect = 6e-32
 Identities = 91/365 (24%), Positives = 176/365 (48%), Gaps = 29/365 (7%)

Query: 15  RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP 74
           +++LA  +S++  A +L NA V+   ++ + L   ++Y   +LA +D  V ++ +P+ I 
Sbjct: 38  KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97

Query: 75  HTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIV 133
           +T+   W+FG+ +C  WL++D   CTAS+ ++ +I+ DRY ++++A+ Y  + T      
Sbjct: 98  YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAG-HAA 156

Query: 134 TLMVAVWVLAFLVNGPMILVSES-WKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAY 192
           T++  VW ++  ++ P +   ++  ++E S+C        Y +  T    F IP +L+  
Sbjct: 157 TMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCG-AFYIPSVLLII 215

Query: 193 FNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSER 252
               IY +   R+ +    S  G    ++++   S    L S  S         S H   
Sbjct: 216 LYGRIYRA--ARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNS---------SLHEGH 264

Query: 253 QRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVF 312
                S +F +  K+              +DS    +R+ +   R R+  K L I+LG F
Sbjct: 265 SHSAGSPLFFNHVKI------------KLADSAL--ERKRISAARERKATKILGIILGAF 310

Query: 313 AVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
            +CW P+ + ++VL     +       +    WL + NS +NP++Y + ++ F++AF KI
Sbjct: 311 IICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKI 370

Query: 373 FCIKK 377
              +K
Sbjct: 371 VPFRK 375


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  133 bits (334), Expect = 3e-31
 Identities = 95/369 (25%), Positives = 182/369 (49%), Gaps = 35/369 (9%)

Query: 12  LSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPL 71
           + +++ ++  +S +A      N+LVI A +V + L H ++Y   +LA++DF V V+ +P 
Sbjct: 20  MPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF 79

Query: 72  YIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSY---RT-QH 126
            I + + E W  G+ +C  WL+ D   CT S+ ++  I+ DRY ++++AV Y   RT +H
Sbjct: 80  SIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH 139

Query: 127 TGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEG-SECEPGFFSEWYILA--ITSFLEF 183
            G+     ++  VW+++  ++ P +     W+ +G S  +       +I++   ++F  F
Sbjct: 140 AGI-----MITIVWIISVFISMPPLF----WRHQGTSRDDECIIKHDHIVSTIYSTFGAF 190

Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTE 243
            IP+ L+      IY +     H  +          +S I      G++       ++  
Sbjct: 191 YIPLALILILYYKIYRAAKTLYHKRQ----------ASRIAKEEVNGQVLLESGEKSTKS 240

Query: 244 VPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAK 303
           V  S+  E+     S  F    K++S T+ S    F    S    +R+ +   R R+ A 
Sbjct: 241 VSTSYVLEKSLSDPSTDFD---KIHS-TVRSLRSEFKHEKS---WRRQKISGTRERKAAT 293

Query: 304 SLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHK 363
           +L ++LG F +CW P+ +  +V++        + +   +A WL + NS +NPL+Y + ++
Sbjct: 294 TLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLA-WLGYLNSLINPLIYTIFNE 352

Query: 364 RFQKAFLKI 372
            F+KAF K+
Sbjct: 353 DFKKAFQKL 361


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  131 bits (330), Expect = 9e-31
 Identities = 94/376 (25%), Positives = 178/376 (47%), Gaps = 39/376 (10%)

Query: 9   NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVIS 68
           ++SL  +V L   ++L+  A  L NA VI      + L   ++Y   +LA++D  V ++ 
Sbjct: 43  SISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILV 102

Query: 69  IPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHT 127
           +P+   +T+   W  G+ +C FWL++D   CTAS+ ++ +I+ DRY ++++AV Y  + T
Sbjct: 103 MPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRT 162

Query: 128 GVLKIVTLMVA-VWVLAFLVNGPMILVSES-WKDEGSECEPGFFSEWYILAITSFLEFVI 185
              K   +M+A VWV +  ++ P     ++  ++E SEC        Y +  T    +  
Sbjct: 163 P--KRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFP 220

Query: 186 PVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVP 245
            ++L+A     +Y  ++        +  P  T            G+  +R  L   +   
Sbjct: 221 TLLLIA-----LYGRIYVEARSRILKQTPNRT------------GKRLTRAQLITDSPGS 263

Query: 246 ASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSL 305
            S  +    R   +   S + +  N +  ++       S AL +++ +   R R+  K+L
Sbjct: 264 TSSVTSINSRVPDVPSESGSPVYVNQVKVRV-------SDALLEKKKLMAARERKATKTL 316

Query: 306 AILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAF-----WLQWFNSFVNPLLYPL 360
            I+LG F VCW P+ + ++V+     A      W+ +A      WL + NS +NP++Y +
Sbjct: 317 GIILGAFIVCWLPFFIISLVMPICKDA-----CWFHLAIFDFFTWLGYLNSLINPIIYTM 371

Query: 361 CHKRFQKAFLKIFCIK 376
            ++ F++AF K+   K
Sbjct: 372 SNEDFKQAFHKLIRFK 387


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  130 bits (328), Expect = 2e-30
 Identities = 99/353 (28%), Positives = 164/353 (46%), Gaps = 43/353 (12%)

Query: 24  LVAFAIML--GNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP-HTLFEW 80
           L AF +M   GN LVIL+   +++L+  ++YF +NLA++D  +    +P       L  W
Sbjct: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162

Query: 81  DFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVW 140
            FG+  C  W   D L CTAS+ ++  IS DRY+ V +++ Y    T   K   ++  +W
Sbjct: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMT-ERKAAAILALLW 221

Query: 141 VLAFLVN-GPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYW 199
           V+A +V+ GP++   E    +   C  G   E      +S   F +P+ ++      +Y 
Sbjct: 222 VVALVVSVGPLLGWKEPVPPDERFC--GITEEAGYAVFSSVCSFYLPMAVIVVMYCRVY- 278

Query: 200 SLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSL 259
                  ++R                       S+ RSL A  +      SE   R    
Sbjct: 279 ------VVAR-----------------------STTRSLEAGVKRERGKASEVVLRIHCR 309

Query: 260 MFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPY 319
             ++         ++K  +F  S SV L     ++  R ++ AK+LAI++GVF +CW P+
Sbjct: 310 GAATGADGAHGMRSAKGHTFRSSLSVRL-----LKFSREKKAAKTLAIVVGVFVLCWFPF 364

Query: 320 SLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
             F + L        P    +++ FWL +FNS VNPL+YP   + F++AFL++
Sbjct: 365 -FFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRL 416


>gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens]
          Length = 67

 Score =  129 bits (323), Expect = 6e-30
 Identities = 66/67 (98%), Positives = 67/67 (100%)

Query: 1  MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
          MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1  MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60

Query: 61 DFFVGVI 67
          DFFVGV+
Sbjct: 61 DFFVGVL 67


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  128 bits (321), Expect = 1e-29
 Identities = 101/395 (25%), Positives = 182/395 (46%), Gaps = 62/395 (15%)

Query: 19  AFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP-HTL 77
           A  ++L+   I+ GN LV +A   +K L+  ++Y  ++LA++D  V  + +P  +    +
Sbjct: 38  ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97

Query: 78  FEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMV 137
            EW F +  C  ++T D ++CTAS+ N+  IS DRY +V+  + Y T+++   ++  ++ 
Sbjct: 98  GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157

Query: 138 AVWVLAFLVNGPMIL-VSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMN 196
            VWVL+F ++ P++  ++ + ++E     P F      +  +S + F +P I+     + 
Sbjct: 158 IVWVLSFTISCPLLFGLNNADQNECIIANPAF------VVYSSIVSFYVPFIVTLLVYIK 211

Query: 197 IYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRL------SSRRSLSASTEVPASFHS 250
           IY  L +R              V++     +FR  L      ++RR+     E+ +S   
Sbjct: 212 IYIVLRRR-----------RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSP 260

Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVAL-----HQREHVELL--------- 296
             + R S +  S       +   S  G  S  DS A      H ++H ++          
Sbjct: 261 PERTRYSPIPPSHHQLTLPD--PSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMP 318

Query: 297 -------------------RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKS 337
                              + ++  + LAI+LGVF +CW P+   T +L+ +     P  
Sbjct: 319 NGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF-FITHILNIHCDCNIP-P 376

Query: 338 VWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
           V Y    WL + NS VNP++Y   +  F+KAFLKI
Sbjct: 377 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKI 411


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  126 bits (316), Expect = 4e-29
 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)

Query: 10  LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
           +++S  + L   +  +    +LGN LVIL+    ++L   + Y+ +NLA++D  +    +
Sbjct: 21  VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80

Query: 70  PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
           P   I   L  W FG+  C  W   D L CTAS+  + +IS DRY+ VS  + Y T  T 
Sbjct: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140

Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
              ++ L+  VW L+ +++ GP+    +   ++ + C    EPG+      +  ++   F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193

Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
            +P+ ++      +Y                        +     RG  S  +   S S 
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230

Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
           +V    H +      S M S++TK +               SV L     ++  R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271

Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
           K+L I++G F +CW P+ L   + SF+     P    ++I FWL + NS +NP++YP   
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 363 KRFQKAF---LKIFCI 375
           + F+KAF   L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  126 bits (316), Expect = 4e-29
 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)

Query: 10  LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
           +++S  + L   +  +    +LGN LVIL+    ++L   + Y+ +NLA++D  +    +
Sbjct: 21  VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80

Query: 70  PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
           P   I   L  W FG+  C  W   D L CTAS+  + +IS DRY+ VS  + Y T  T 
Sbjct: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140

Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
              ++ L+  VW L+ +++ GP+    +   ++ + C    EPG+      +  ++   F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193

Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
            +P+ ++      +Y                        +     RG  S  +   S S 
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230

Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
           +V    H +      S M S++TK +               SV L     ++  R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271

Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
           K+L I++G F +CW P+ L   + SF+     P    ++I FWL + NS +NP++YP   
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 363 KRFQKAF---LKIFCI 375
           + F+KAF   L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  126 bits (316), Expect = 4e-29
 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)

Query: 10  LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
           +++S  + L   +  +    +LGN LVIL+    ++L   + Y+ +NLA++D  +    +
Sbjct: 21  VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80

Query: 70  PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
           P   I   L  W FG+  C  W   D L CTAS+  + +IS DRY+ VS  + Y T  T 
Sbjct: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140

Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
              ++ L+  VW L+ +++ GP+    +   ++ + C    EPG+      +  ++   F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193

Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
            +P+ ++      +Y                        +     RG  S  +   S S 
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230

Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
           +V    H +      S M S++TK +               SV L     ++  R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271

Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
           K+L I++G F +CW P+ L   + SF+     P    ++I FWL + NS +NP++YP   
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 363 KRFQKAF---LKIFCI 375
           + F+KAF   L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  126 bits (316), Expect = 4e-29
 Identities = 98/376 (26%), Positives = 170/376 (45%), Gaps = 60/376 (15%)

Query: 10  LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISI 69
           +++S  + L   +  +    +LGN LVIL+    ++L   + Y+ +NLA++D  +    +
Sbjct: 21  VNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL 80

Query: 70  PLY-IPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTG 128
           P   I   L  W FG+  C  W   D L CTAS+  + +IS DRY+ VS  + Y T  T 
Sbjct: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140

Query: 129 VLKIVTLMVAVWVLAFLVN-GPMILVSESWKDEGSEC----EPGFFSEWYILAITSFLEF 183
              ++ L+  VW L+ +++ GP+    +   ++ + C    EPG+      +  ++   F
Sbjct: 141 RRGLMALL-CVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY------VLFSALGSF 193

Query: 184 VIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS-RRSLSAST 242
            +P+ ++      +Y                        +     RG  S  +   S S 
Sbjct: 194 YLPLAIILVMYCRVY-----------------------VVAKRESRGLKSGLKTDKSDSE 230

Query: 243 EVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLA 302
           +V    H +      S M S++TK +               SV L     ++  R ++ A
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHF--------------SVRL-----LKFSREKKAA 271

Query: 303 KSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCH 362
           K+L I++G F +CW P+ L   + SF+     P    ++I FWL + NS +NP++YP   
Sbjct: 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK-PSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 363 KRFQKAF---LKIFCI 375
           + F+KAF   L+I C+
Sbjct: 331 QEFKKAFQNVLRIQCL 346


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  126 bits (316), Expect = 4e-29
 Identities = 103/362 (28%), Positives = 172/362 (47%), Gaps = 23/362 (6%)

Query: 28  AIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP--LYIPHTLFEWDFGKE 85
           AI+ GN LV +A + ++ L+  ++Y  ++LA++D  V  + +P  +Y+  T   W+F + 
Sbjct: 42  AIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRI 101

Query: 86  ICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYR--TQHTGVLKIVTLMVAVWVLA 143
            C  ++T D ++CTAS+ N+  IS DRY +V   V Y+  T  +   ++  ++ AVWVLA
Sbjct: 102 CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLA 161

Query: 144 FLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSL 201
           F V+ P++    +  D    S   P F    Y   ++ +L F + V++ A   + +    
Sbjct: 162 FAVSCPLLFGFNTTGDPTVCSISNPDFVI--YSSVVSFYLPFGVTVLVYARIYVVLKQRR 219

Query: 202 WKR---DHLSRCQS-HPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSER----- 252
            KR      S+C S  PG       +        L    S+   T +      ER     
Sbjct: 220 RKRILTRQNSQCNSVRPGFP--QQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELK 277

Query: 253 --QRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLG 310
             ++ ++SL  +   K++        G  S S  +   Q   V  LR ++  + +AI+LG
Sbjct: 278 REEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVP-LREKKATQMVAIVLG 336

Query: 311 VFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFL 370
            F VCW P+ L T VL+ +          Y    WL + NS +NP++Y   +  F+KAFL
Sbjct: 337 AFIVCWLPFFL-THVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395

Query: 371 KI 372
           KI
Sbjct: 396 KI 397


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  124 bits (312), Expect = 1e-28
 Identities = 99/351 (28%), Positives = 164/351 (46%), Gaps = 34/351 (9%)

Query: 28  AIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP--LYIPHTLFEWDFGKE 85
           AI+ GN LV +A + ++ L+  ++Y  ++LA++D  V  + +P  +Y+  T   W+F + 
Sbjct: 42  AIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRI 101

Query: 86  ICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYR--TQHTGVLKIVTLMVAVWVLA 143
            C  ++T D ++CTAS+ N+  IS DRY +V   V Y+  T  +   ++  ++ AVWVLA
Sbjct: 102 CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLA 161

Query: 144 FLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSL 201
           F V+ P++    +  D    S   P F    Y   ++ +L F + V++ A     IY  L
Sbjct: 162 FAVSCPLLFGFNTTGDPTVCSISNPDFVI--YSSVVSFYLPFGVTVLVYA----RIYVVL 215

Query: 202 WKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261
            +R           +    ++ C        S R      T  P   H E +R  S    
Sbjct: 216 KQR-------RRKRILTRQNSQCN-------SVRPGFPQQTLSPDPAHLELKRYYS---I 258

Query: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321
              T +       + G   + +      R  +  LR ++  + +AI+LG F VCW P+ L
Sbjct: 259 CQDTALGGPGFQERGGELKREEKT----RNSLMPLREKKATQMVAIVLGAFIVCWLPFFL 314

Query: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
            T VL+ +          Y    WL + NS +NP++Y   +  F+KAFLKI
Sbjct: 315 -THVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKI 364


>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
          Length = 590

 Score =  117 bits (292), Expect = 2e-26
 Identities = 83/274 (30%), Positives = 135/274 (49%), Gaps = 11/274 (4%)

Query: 16  VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPH 75
           V +AF   ++A   ++GN LVI++F V+K L+  ++YF L+LA +D  +GVIS+ L+  +
Sbjct: 69  VFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTY 128

Query: 76  TLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVT 134
            +   W  G   C  WL  DY+   ASV N+++IS+DRY S++  ++YR + T     V 
Sbjct: 129 IIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVM 188

Query: 135 LMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVIPVILV 190
           + +A WV++F++  P IL  + +  + +    EC   F SE  I   T+   F +PV ++
Sbjct: 189 IGLA-WVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIM 247

Query: 191 AYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHS 250
                 +YW ++K     R +   GL A  +     +F     S RS S+      S   
Sbjct: 248 TI----LYWRIYKETE-KRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302

Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDS 284
             +R+     F   TK    +        S SDS
Sbjct: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDS 336



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 44/177 (24%), Positives = 89/177 (50%), Gaps = 23/177 (12%)

Query: 231 RLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSN---------------TIASK 275
           +L +++S+      P SF     + +S++  +  + +NS+               T+A +
Sbjct: 407 KLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKR 466

Query: 276 MGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGP 335
               ++S    + +R+ + L++ ++ A++L+ +L  F + W PY++  +V +F  S   P
Sbjct: 467 FALKTRSQ---ITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI-P 522

Query: 336 KSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIF---CIKKQPLPSQHSRSVS 389
           K+ W  + +WL + NS VNP+ Y LC+K F+  F  +    C KK+    Q+ +  S
Sbjct: 523 KTFW-NLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQS 578


>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
          Length = 357

 Score =  112 bits (279), Expect = 7e-25
 Identities = 89/363 (24%), Positives = 162/363 (44%), Gaps = 58/363 (15%)

Query: 16  VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFL-NLAISDFFVGVISIPLYIP 74
           +TL  F+    FA  L    ++LA ++     HR  +  + ++A+SD  V  + +PL + 
Sbjct: 44  LTLLGFLVAATFAWNL----LVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLV 99

Query: 75  HTLF--EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKI 132
           H L    W  G+ +C  W+  D L CTAS++N+  I+ DRY S++  + Y T  T     
Sbjct: 100 HELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVS 158

Query: 133 VTLMVAVWVLAFLVNGPMILV--SESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILV 190
             ++   W L+ +++   +L    E++ +   EC+      + + +      F +P+ +V
Sbjct: 159 NVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVG--AFYLPLCVV 216

Query: 191 AYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHS 250
            +    +YW ++K                       + + R+ SR++ S S  +  +   
Sbjct: 217 LF----VYWKIYK-----------------------AAKFRVGSRKTNSVS-PISEAVEV 248

Query: 251 ERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLG 310
           +   ++  ++F         T+     +F         Q+E       +R A  + IL+G
Sbjct: 249 KDSAKQPQMVF---------TVRHATVTFQPEGDTWREQKE-------QRAALMVGILIG 292

Query: 311 VFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFL 370
           VF +CW P+ L T ++S   S   P ++W  I  WL + NSF NPL+Y   +K +  AF 
Sbjct: 293 VFVLCWIPFFL-TELISPLCSCDIP-AIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350

Query: 371 KIF 373
             F
Sbjct: 351 NFF 353


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  110 bits (276), Expect = 2e-24
 Identities = 96/395 (24%), Positives = 177/395 (44%), Gaps = 47/395 (11%)

Query: 2   PDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISD 61
           P + S   LS      +   M+L+   I+ GN LVI+A      L+  ++ F ++LA +D
Sbjct: 45  PASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASAD 104

Query: 62  FFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 120
             +G++ +P      ++  W++G   C  W + D L  TAS+  + +I+ DRYL++++  
Sbjct: 105 LVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPF 164

Query: 121 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSE---------CEPGFFSE 171
            Y++  T   +   L+  VW ++ LV+   IL+   W+ E  E         C     + 
Sbjct: 165 RYQSLLTRA-RARGLVCTVWAISALVSFLPILM-HWWRAESDEARRCYNDPKCCDFVTNR 222

Query: 172 WYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGR 231
            Y +A +S + F +P+ ++A+  + ++    K+                 + C   F G 
Sbjct: 223 AYAIA-SSVVSFYVPLCIMAFVYLRVFREAQKQ-------------VKKIDSCERRFLGG 268

Query: 232 LSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE 291
            +   S S S  VPA        R ++   ++ T   +N  A K             +  
Sbjct: 269 PARPPSPSPS-PVPAPAPPPGPPRPAA---AAATAPLANGRAGK------------RRPS 312

Query: 292 HVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNS 351
            +  LR ++  K+L I++GVF +CW P+ L  +V +F+      +   +    WL + NS
Sbjct: 313 RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDR--LFVFFNWLGYANS 370

Query: 352 FVNPLLYPLCHK-RFQKAFLKIFCIKKQPLPSQHS 385
             NP++Y  C    F+KAF  + C  ++    +H+
Sbjct: 371 AFNPIIY--CRSPDFRKAFQGLLCCARRAARRRHA 403


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score =  108 bits (271), Expect = 6e-24
 Identities = 92/394 (23%), Positives = 173/394 (43%), Gaps = 48/394 (12%)

Query: 24  LVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDF 82
           L+ F ++ GN LV++A +  + LR   + F ++LA +D  V  + +P  + + L   W F
Sbjct: 61  LIVFTVV-GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYF 119

Query: 83  GKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVL 142
           G+  C  +L  D L CT+S+ ++  IS DRY SV+ AV Y  + T   ++   +VAVW++
Sbjct: 120 GQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRT-PRRVKATIVAVWLI 178

Query: 143 AFLVNGPMILVSESWKDEGSECEPGFFSE-WYILAITSFLEFVIPVILVAYFNMNIYWSL 201
           + +++ P ++      D  +  + G   E WYIL+ +    F  P +++      IY   
Sbjct: 179 SAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILS-SCIGSFFAPCLIMGLVYARIYRVA 237

Query: 202 WKRDHLSRCQSHP----GLTAVSSNICGHSFRGRLSSRRSLSASTEVP--ASFHSERQRR 255
             R      +  P    G +  + N  G +     +   +   +   P  +S  +ER+RR
Sbjct: 238 KLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRR 297

Query: 256 KSSLMFSSRTK------------------------MNSNTIASKMGSFSQSDSVALH--- 288
           + +L    R +                        + ++      G  S++ S ++    
Sbjct: 298 RGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFL 357

Query: 289 ----------QREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSV 338
                      R  V   R +R    LA+++GVF +CW P+     +      A      
Sbjct: 358 SRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGP 417

Query: 339 WYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKI 372
            ++  FW+ + NS +NP++Y + ++ F+++F  I
Sbjct: 418 LFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHI 451


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  108 bits (270), Expect = 8e-24
 Identities = 96/383 (25%), Positives = 168/383 (43%), Gaps = 42/383 (10%)

Query: 4   TNSTINLSLSTRVT-----LAFFMSLVAFAIM--LGNALVILAFVVDKNLRHRSSYFFLN 56
           TN T   S++ R       +   M+LV    +  L N  VI+A    K L   ++Y   +
Sbjct: 4   TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63

Query: 57  LAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLS 115
           LA++D  V V+ +PL I + + + W  G  +C  WL+ D   CT S+ ++ +I+ DRY +
Sbjct: 64  LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123

Query: 116 VSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYIL 175
           ++NA+ Y  + T   +   +++ VW ++  ++ P +      +      +     +  I 
Sbjct: 124 ITNAIEYARKRT-AKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIY 182

Query: 176 AITSFL-EFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSS 234
            I S L  F IP+ L+      IY       H ++                  ++ R SS
Sbjct: 183 TIYSTLGAFYIPLTLILILYYRIY-------HAAK----------------SLYQKRGSS 219

Query: 235 RRSLSASTEVPASFHSERQRRK---SSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQRE 291
           R   + ST+   SF S +  +    S    S  T       AS       +D     +R+
Sbjct: 220 RHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQ 279

Query: 292 HVELLRARRLAKSLAILLGVFAVCWAPYSLFTIV--LSFYSSATGPKSVWYRIAFWLQWF 349
            +   R R+ A+ L ++LG F + W P+ +  ++  LS Y+ ++           WL + 
Sbjct: 280 QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVAD----FLTWLGYV 335

Query: 350 NSFVNPLLYPLCHKRFQKAFLKI 372
           NS +NPLLY   ++ F+ AF K+
Sbjct: 336 NSLINPLLYTSFNEDFKLAFKKL 358


>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
          Length = 532

 Score =  108 bits (270), Expect = 8e-24
 Identities = 79/265 (29%), Positives = 133/265 (50%), Gaps = 12/265 (4%)

Query: 16  VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPH 75
           +T+A   ++V+   ++GN LV+++F V+  L+  ++Y+ L+LA +D  +G+ S+ LY  +
Sbjct: 31  ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90

Query: 76  TLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVT 134
            L   W  G   C  WL  DY+   ASV N+++IS+DRY S++  ++YR + T   K   
Sbjct: 91  ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP--KRAG 148

Query: 135 LMVAV-WVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVIPVIL 189
           +M+ + W+++F++  P IL  +    + +    EC+  F SE  I   T+   F IPV +
Sbjct: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSV 208

Query: 190 VAYFNMNIYWSLWKR-DHLSRCQSHPGLTAVSSNICGHS--FRGRLSSRRSLSASTE-VP 245
           +      IY    KR   L+  Q    +T        H   FR  L   R   A  E   
Sbjct: 209 MTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQ 268

Query: 246 ASFHSERQRRKSSLMFSSRTKMNSN 270
           AS+ S R+   ++   S  T  ++N
Sbjct: 269 ASWSSSRRSTSTTGKPSQATGPSAN 293



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 28/81 (34%), Positives = 52/81 (64%), Gaps = 2/81 (2%)

Query: 289 QREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQW 348
           +R+ V L++ R+ A++L+ +L  F + W PY++  +V +F      P ++W+ + +WL +
Sbjct: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCV-PVTLWH-LGYWLCY 485

Query: 349 FNSFVNPLLYPLCHKRFQKAF 369
            NS VNP+ Y LC++ F+K F
Sbjct: 486 VNSTVNPICYALCNRTFRKTF 506


>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  105 bits (262), Expect = 7e-23
 Identities = 70/219 (31%), Positives = 119/219 (54%), Gaps = 28/219 (12%)

Query: 4   TNSTINLSLSTRVTLAFFMSLVAFAIML----GNALVILAFVVDKNLRHRSSYFFLNLAI 59
           +N+++ L+   +     F+ LVA ++ L    GN LV+++  V+++L+  ++YF  +LA 
Sbjct: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67

Query: 60  SDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSN 118
           +D  +GV S+ LY  +T+   W  G  +C  WL  DY++  ASV N+++IS+DRY  V+ 
Sbjct: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127

Query: 119 AVSYRTQHTGVLKIVTLMV-AVWVLAFLVNGPMILVSESWK-------DEGSECEPGFFS 170
            ++Y  + T   K+  +M+ A WVL+F++  P IL    W+        E  EC   FFS
Sbjct: 128 PLTYPVKRT--TKMAGMMIAAAWVLSFILWAPAILF---WQFIVGVRTVEDGECYIQFFS 182

Query: 171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSR 209
              +   T+   F +PVI++      +YW      H+SR
Sbjct: 183 NAAVTFGTAIAAFYLPVIIMTV----LYW------HISR 211



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 297 RARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPL 356
           R +++ +++  +L  F + WAPY++  ++ +F +    P +VW  I +WL + NS +NP 
Sbjct: 381 REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCI-PNTVW-TIGYWLCYINSTINPA 438

Query: 357 LYPLCHKRFQKAF 369
            Y LC+  F+K F
Sbjct: 439 CYALCNATFKKTF 451


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,274,926
Number of Sequences: 37866
Number of extensions: 523069
Number of successful extensions: 4315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 380
Number of HSP's that attempted gapping in prelim test: 2995
Number of HSP's gapped (non-prelim): 1119
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press