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Search of human proteins with 14249614
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249614 synaptotagmin-like 1 [Homo sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249614 synaptotagmin-like 1 [Homo sapiens] 1110 0.0
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens] 332 4e-91
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 332 7e-91
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 330 2e-90
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 330 2e-90
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens] 328 6e-90
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens] 328 6e-90
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens] 328 6e-90
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens] 328 6e-90
gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens] 322 4e-88
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 263 4e-70
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 263 4e-70
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 234 2e-61
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 234 2e-61
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 232 8e-61
gi|110227631 synaptotagmin-like 3 [Homo sapiens] 181 2e-45
gi|211059429 synaptotagmin II [Homo sapiens] 121 1e-27
gi|31543670 synaptotagmin II [Homo sapiens] 121 1e-27
gi|92859638 synaptotagmin V [Homo sapiens] 120 4e-27
gi|238550198 synaptotagmin III [Homo sapiens] 119 9e-27
gi|238550196 synaptotagmin III [Homo sapiens] 119 9e-27
gi|14150054 synaptotagmin III [Homo sapiens] 119 9e-27
gi|38570146 synaptotagmin VII [Homo sapiens] 115 1e-25
gi|209447073 synaptotagmin I [Homo sapiens] 110 3e-24
gi|5032139 synaptotagmin I [Homo sapiens] 110 3e-24
gi|209447070 synaptotagmin I [Homo sapiens] 110 3e-24
gi|45504376 synaptotagmin VI [Homo sapiens] 104 2e-22
gi|39752671 synaptotagmin X [Homo sapiens] 104 2e-22
gi|28376627 synaptotagmin IX [Homo sapiens] 101 2e-21
gi|47078261 double C2-like domains, alpha [Homo sapiens] 97 5e-20
>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
Length = 550
Score = 1110 bits (2871), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEE 60
MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEE
Sbjct: 1 MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEE 60
Query: 61 GRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGH 120
GRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGH
Sbjct: 61 GRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGH 120
Query: 121 DREAEAAVKEKEEGPEPRLTIDEAPQERLRETEASDPEEASQAQEDPGQGDQQVCAEEAD 180
DREAEAAVKEKEEGPEPRLTIDEAPQERLRETEASDPEEASQAQEDPGQGDQQVCAEEAD
Sbjct: 121 DREAEAAVKEKEEGPEPRLTIDEAPQERLRETEASDPEEASQAQEDPGQGDQQVCAEEAD 180
Query: 181 PELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSG 240
PELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSG
Sbjct: 181 PELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSG 240
Query: 241 SQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPD 300
SQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPD
Sbjct: 241 SQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPD 300
Query: 301 KQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLD 360
KQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLD
Sbjct: 301 KQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLD 360
Query: 361 TWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEAR 420
TWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEAR
Sbjct: 361 TWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEAR 420
Query: 421 DLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACA 480
DLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACA
Sbjct: 421 DLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACA 480
Query: 481 ELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLL 540
ELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLL
Sbjct: 481 ELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLL 540
Query: 541 PLRTNLAPRT 550
PLRTNLAPRT
Sbjct: 541 PLRTNLAPRT 550
>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
Length = 1272
Score = 332 bits (852), Expect = 4e-91
Identities = 179/415 (43%), Positives = 257/415 (61%), Gaps = 26/415 (6%)
Query: 155 SDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEP--RPQQAQ--TKAASQILENG 210
+ PEE ++ ED + DQ+ E P + P P + + +K+ L++
Sbjct: 849 NQPEELVRSAEDDEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDE 908
Query: 211 EEAPGPDPS------LDRMLSSSSSVSSLNSST-------LSGSQMSL-SGDAEAVQVRG 256
+ D + L R S SS+++L+SS+ +SGS MS+ SGD ++V+G
Sbjct: 909 SDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKG 968
Query: 257 SVHFALHYEPGAAELRVHVIQCQGLAAA--RRRRSDPYVKSYLLPDK--QSKRKTAVKKR 312
++ FA+ Y EL V V QC+ LAAA +++RSDPYVK+YLLPDK K+KT V K+
Sbjct: 969 NIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKK 1028
Query: 313 NLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT--- 369
LNPV+NE LRY + + L+ + L+LS+WHR++ RN FLGEVE+ L+TWDW ++
Sbjct: 1029 TLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQL 1088
Query: 370 -WLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAG 428
W PL+ + P + +RG + L+L+YVP G LP +GE+H WVKE DL LR
Sbjct: 1089 RWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGS 1148
Query: 429 SLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHG 488
L+++V+C +LPD S+ SRQ+TR V ++ +P+FNHTMVYDGF P DL +AC EL++WDH
Sbjct: 1149 HLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHY 1208
Query: 489 ALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLR 543
L N+ LGG R+ GTG SYG +V WMDST EE LW+ ++ P W++ LPLR
Sbjct: 1209 KLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 1263
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 332 bits (850), Expect = 7e-91
Identities = 172/424 (40%), Positives = 256/424 (60%), Gaps = 13/424 (3%)
Query: 129 KEKEEGPEPRLTIDEAPQERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASG 188
+++++G E + +P + E A+ + ++ Q + EL ++
Sbjct: 482 RDRQQGSEE----EPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAE 537
Query: 189 GEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSGSQMSL-SG 247
+++P + + +I + P D++ S SV + +SGS MS+ SG
Sbjct: 538 DDEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSG 597
Query: 248 DAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA--RRRRSDPYVKSYLLPDK--QS 303
D ++V+G++ FA+ Y EL V V QC+ LAAA +++RSDPYVK+YLLPDK
Sbjct: 598 DFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMG 657
Query: 304 KRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWD 363
K+KT V K+ LNPV+NE LRY + + L+ + L+LS+WHR++ RN FLGEVE+ L+TWD
Sbjct: 658 KKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWD 717
Query: 364 WGSEPT----WLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEA 419
W ++ W PL+ + P + +RG + L+L+YVP G LP +GE+H WVKE
Sbjct: 718 WDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKEC 777
Query: 420 RDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQAC 479
DL LR L+++V+C +LPD S+ SRQ+TR V ++ +P+FNHTMVYDGF P DL +AC
Sbjct: 778 LDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 837
Query: 480 AELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGL 539
EL++WDH L N+ LGG R+ GTG SYG +V WMDST EE LW+ ++ P W++
Sbjct: 838 VELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEAT 897
Query: 540 LPLR 543
LPLR
Sbjct: 898 LPLR 901
Score = 94.0 bits (232), Expect = 3e-19
Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 10/236 (4%)
Query: 31 LLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQ 90
++DLSFLTEEEQEAI VLQRDA L++ EE RV L + D QLK ++G WF EA+++
Sbjct: 1 MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK 60
Query: 91 RHHNAHFGSDLVRASMRRKK-STRGDQAPGHDREAEAA-----VKEKEEGPEPRLTIDEA 144
RH + G+D++RASMR+K+ +Q+ + A+ + K+ PE ++E
Sbjct: 61 RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEP 120
Query: 145 PQERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAAS 204
++ + +S + + D Q + + + P + + QTK +
Sbjct: 121 EEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTK--N 178
Query: 205 QILENGEEAPGPDPSLDRMLSS--SSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSV 258
+ +NG D + S S+V+ + L S+ +L G + Q++ +
Sbjct: 179 EQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPI 234
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 330 bits (847), Expect = 2e-90
Identities = 184/446 (41%), Positives = 265/446 (59%), Gaps = 20/446 (4%)
Query: 115 DQAPGHDREAEAAVKEKEEGPE---PRLTIDEAPQERLRETEASD-PEEASQAQED---- 166
D+ G + E +K E P ++++ + + + + PEE ++ ED
Sbjct: 484 DRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTV 543
Query: 167 PGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSS 226
P Q D + + + + +T AS+ SL LSS
Sbjct: 544 PTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTN-LSS 602
Query: 227 SSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA- 284
SS ++SL+S +SGS MS+ SGD ++V+G++ FA+ Y EL V V QC+ LAAA
Sbjct: 603 SSGMTSLSS--VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAAD 660
Query: 285 -RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVW 341
+++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+ + L+LS+W
Sbjct: 661 VKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIW 720
Query: 342 HRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRGLLALSLKYV 397
HR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG + L+L+YV
Sbjct: 721 HRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYV 780
Query: 398 PAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSL 457
P G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ+TR V ++
Sbjct: 781 PEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTT 840
Query: 458 SPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDS 517
+P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SYG +V WMDS
Sbjct: 841 NPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDS 900
Query: 518 TPEEKQLWQALLEQPCEWVDGLLPLR 543
T EE LW+ ++ P W++ LPLR
Sbjct: 901 TSEEVALWEKMVNSPNTWIEATLPLR 926
Score = 94.0 bits (232), Expect = 3e-19
Identities = 65/234 (27%), Positives = 111/234 (47%), Gaps = 32/234 (13%)
Query: 31 LLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQ 90
++DLSFLTEEEQEAI VLQRDA L++ EE RV L + D QLK ++G WF EA+++
Sbjct: 1 MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK 60
Query: 91 RHHNAHFGSDLVRASMRRKK-STRGDQAPGHDR------------------EAEAAVKEK 131
RH + G+D++RASMR+K+ +Q+ + E V+E
Sbjct: 61 RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEP 120
Query: 132 EEGPEPRLTIDEAPQERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQ 191
EE P +P + +S + + + P ++ + P Q
Sbjct: 121 EEDAAP-----ASPSSSVVNPASSVIDMSQENTRKPNVSPEKQRKNPFNSSKLPEGHSSQ 175
Query: 192 EPRPQQA--------QTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSST 237
+ + +Q+ QT ++ E+ E++ D S+ ++ S ++ L++ +
Sbjct: 176 QTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGS 229
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 330 bits (847), Expect = 2e-90
Identities = 184/446 (41%), Positives = 265/446 (59%), Gaps = 20/446 (4%)
Query: 115 DQAPGHDREAEAAVKEKEEGPE---PRLTIDEAPQERLRETEASD-PEEASQAQED---- 166
D+ G + E +K E P ++++ + + + + PEE ++ ED
Sbjct: 483 DRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTV 542
Query: 167 PGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSS 226
P Q D + + + + +T AS+ SL LSS
Sbjct: 543 PTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTN-LSS 601
Query: 227 SSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA- 284
SS ++SL+S +SGS MS+ SGD ++V+G++ FA+ Y EL V V QC+ LAAA
Sbjct: 602 SSGMTSLSS--VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAAD 659
Query: 285 -RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVW 341
+++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+ + L+LS+W
Sbjct: 660 VKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIW 719
Query: 342 HRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRGLLALSLKYV 397
HR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG + L+L+YV
Sbjct: 720 HRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYV 779
Query: 398 PAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSL 457
P G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ+TR V ++
Sbjct: 780 PEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTT 839
Query: 458 SPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDS 517
+P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SYG +V WMDS
Sbjct: 840 NPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDS 899
Query: 518 TPEEKQLWQALLEQPCEWVDGLLPLR 543
T EE LW+ ++ P W++ LPLR
Sbjct: 900 TSEEVALWEKMVNSPNTWIEATLPLR 925
Score = 94.0 bits (232), Expect = 3e-19
Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 10/236 (4%)
Query: 31 LLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQ 90
++DLSFLTEEEQEAI VLQRDA L++ EE RV L + D QLK ++G WF EA+++
Sbjct: 1 MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK 60
Query: 91 RHHNAHFGSDLVRASMRRKK-STRGDQAPGHDREAEAA-----VKEKEEGPEPRLTIDEA 144
RH + G+D++RASMR+K+ +Q+ + A+ + K+ PE ++E
Sbjct: 61 RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEP 120
Query: 145 PQERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAAS 204
++ + +S + + D Q + + + P + + QTK +
Sbjct: 121 EEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTK--N 178
Query: 205 QILENGEEAPGPDPSLDRMLSS--SSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSV 258
+ +NG D + S S+V+ + L S+ +L G + Q++ +
Sbjct: 179 EQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPI 234
>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
Length = 376
Score = 328 bits (842), Expect = 6e-90
Identities = 167/335 (49%), Positives = 229/335 (68%), Gaps = 11/335 (3%)
Query: 218 PSLDRMLSSSSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVI 276
PS LSSSS ++SL+S +SGS MS+ SGD ++V+G++ FA+ Y EL V V
Sbjct: 35 PSSLTNLSSSSGMTSLSS--VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVA 92
Query: 277 QCQGLAAA--RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQ 332
QC+ LAAA +++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+
Sbjct: 93 QCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILK 152
Query: 333 GRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRG 388
+ L+LS+WHR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG
Sbjct: 153 TQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 212
Query: 389 LLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQ 448
+ L+L+YVP G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ
Sbjct: 213 EMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQ 272
Query: 449 RTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSY 508
+TR V ++ +P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SY
Sbjct: 273 KTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSY 332
Query: 509 GLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLR 543
G +V WMDST EE LW+ ++ P W++ LPLR
Sbjct: 333 GTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 367
>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
Length = 365
Score = 328 bits (842), Expect = 6e-90
Identities = 167/335 (49%), Positives = 229/335 (68%), Gaps = 11/335 (3%)
Query: 218 PSLDRMLSSSSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVI 276
PS LSSSS ++SL+S +SGS MS+ SGD ++V+G++ FA+ Y EL V V
Sbjct: 24 PSSLTNLSSSSGMTSLSS--VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVA 81
Query: 277 QCQGLAAA--RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQ 332
QC+ LAAA +++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+
Sbjct: 82 QCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILK 141
Query: 333 GRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRG 388
+ L+LS+WHR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG
Sbjct: 142 TQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 201
Query: 389 LLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQ 448
+ L+L+YVP G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ
Sbjct: 202 EMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQ 261
Query: 449 RTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSY 508
+TR V ++ +P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SY
Sbjct: 262 KTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSY 321
Query: 509 GLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLR 543
G +V WMDST EE LW+ ++ P W++ LPLR
Sbjct: 322 GTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 356
>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
Length = 376
Score = 328 bits (842), Expect = 6e-90
Identities = 167/335 (49%), Positives = 229/335 (68%), Gaps = 11/335 (3%)
Query: 218 PSLDRMLSSSSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVI 276
PS LSSSS ++SL+S +SGS MS+ SGD ++V+G++ FA+ Y EL V V
Sbjct: 35 PSSLTNLSSSSGMTSLSS--VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVA 92
Query: 277 QCQGLAAA--RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQ 332
QC+ LAAA +++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+
Sbjct: 93 QCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILK 152
Query: 333 GRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRG 388
+ L+LS+WHR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG
Sbjct: 153 TQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 212
Query: 389 LLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQ 448
+ L+L+YVP G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ
Sbjct: 213 EMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQ 272
Query: 449 RTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSY 508
+TR V ++ +P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SY
Sbjct: 273 KTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSY 332
Query: 509 GLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLR 543
G +V WMDST EE LW+ ++ P W++ LPLR
Sbjct: 333 GTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 367
>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
Length = 1256
Score = 328 bits (842), Expect = 6e-90
Identities = 167/335 (49%), Positives = 229/335 (68%), Gaps = 11/335 (3%)
Query: 218 PSLDRMLSSSSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVI 276
PS LSSSS ++SL+S +SGS MS+ SGD ++V+G++ FA+ Y EL V V
Sbjct: 915 PSSLTNLSSSSGMTSLSS--VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVA 972
Query: 277 QCQGLAAA--RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQ 332
QC+ LAAA +++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+
Sbjct: 973 QCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILK 1032
Query: 333 GRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRG 388
+ L+LS+WHR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG
Sbjct: 1033 TQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 1092
Query: 389 LLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQ 448
+ L+L+YVP G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ
Sbjct: 1093 EMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQ 1152
Query: 449 RTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSY 508
+TR V ++ +P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SY
Sbjct: 1153 KTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSY 1212
Query: 509 GLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLR 543
G +V WMDST EE LW+ ++ P W++ LPLR
Sbjct: 1213 GTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 1247
>gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]
Length = 336
Score = 322 bits (826), Expect = 4e-88
Identities = 160/326 (49%), Positives = 220/326 (67%), Gaps = 9/326 (2%)
Query: 227 SSSVSSLNSSTLSGSQMSL-SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA- 284
S SV + +SGS MS+ SGD ++V+G++ FA+ Y EL V V QC+ LAAA
Sbjct: 2 SKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAAD 61
Query: 285 -RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVW 341
+++RSDPYVK+YLLPDK K+KT V K+ LNPV+NE LRY + + L+ + L+LS+W
Sbjct: 62 VKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIW 121
Query: 342 HRESLGRNIFLGEVEVPLDTWDWGSEPT----WLPLQPRVPPSPDDLPSRGLLALSLKYV 397
HR++ RN FLGEVE+ L+TWDW ++ W PL+ + P + +RG + L+L+YV
Sbjct: 122 HRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYV 181
Query: 398 PAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSL 457
P G LP +GE+H WVKE DL LR L+++V+C +LPD S+ SRQ+TR V ++
Sbjct: 182 PEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTT 241
Query: 458 SPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDS 517
+P+FNHTMVYDGF P DL +AC EL++WDH L N+ LGG R+ GTG SYG +V WMDS
Sbjct: 242 NPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDS 301
Query: 518 TPEEKQLWQALLEQPCEWVDGLLPLR 543
T EE LW+ ++ P W++ LPLR
Sbjct: 302 TSEEVALWEKMVNSPNTWIEATLPLR 327
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 263 bits (671), Expect = 4e-70
Identities = 188/558 (33%), Positives = 286/558 (51%), Gaps = 87/558 (15%)
Query: 75 QLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRK---------------KSTRGDQAPG 119
+LK TGDWF + + R GS+++R S+R K ++ GD PG
Sbjct: 110 ELKKATGDWFYDQKVNRFAY-RTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPG 168
Query: 120 H----DREAEAAVKEKEEGPEPRLTIDEAPQERLRE-TEASDPEEASQAQEDPGQGDQ-- 172
+R+ E +V + + + EA E L T SD + + G +
Sbjct: 169 RKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWK 228
Query: 173 QVCAEEADPELEPASGGEQ-----------------------------EPRPQQAQTKAA 203
++ A ++ E E GG+ + RP+ ++
Sbjct: 229 KMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESG 288
Query: 204 SQILENGEEAPGPDPSLD---------------RMLSSSSSVSSLNSSTLSGSQMSL--- 245
S + + + PG + ++ R + SS+ S +S + GS MS+
Sbjct: 289 S-LGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSE 347
Query: 246 SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA--RRRRSDPYVKSYLLPDK-- 301
+GD + V G + F+L YE L VHV +C LA A ++RS+PYVK+YLLPDK
Sbjct: 348 AGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSR 407
Query: 302 QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDT 361
Q KRKT++K+ +NP+++ETLRY +P++ L R L SVWH GRN FLGE E+ +D+
Sbjct: 408 QGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
Query: 362 WDWGSE-PTWLPLQPRV-PPSPDDLPS-RGLLALSLKYVPAGSEGAGLP-------PSGE 411
W + LPL ++ SP LPS +G L +SLKY+PA G GE
Sbjct: 468 WKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGE 527
Query: 412 LHFWVKEARDLLPLRA-GSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGF 470
L W+KEA++L +A G+ D++V+ ++LP ++AS+++T V++++L+P +NHT VY+G
Sbjct: 528 LQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGV 587
Query: 471 GPADLRQACAELSLWDHGALA-NRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALL 529
DL+ C EL++WD LA N LGG RL +GTG S G V WMDST EE LWQ +
Sbjct: 588 RLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMR 647
Query: 530 EQPCEWVDGLLPLRTNLA 547
+ P W +G L LR+++A
Sbjct: 648 QYPGSWAEGTLQLRSSMA 665
Score = 43.9 bits (102), Expect = 4e-04
Identities = 20/37 (54%), Positives = 29/37 (78%)
Query: 31 LLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67
LLDLSFL+EEE++ I VLQRD +R+ +E R+ +L+
Sbjct: 4 LLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLK 40
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 263 bits (671), Expect = 4e-70
Identities = 188/558 (33%), Positives = 286/558 (51%), Gaps = 87/558 (15%)
Query: 75 QLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRK---------------KSTRGDQAPG 119
+LK TGDWF + + R GS+++R S+R K ++ GD PG
Sbjct: 110 ELKKATGDWFYDQKVNRFAY-RTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPG 168
Query: 120 H----DREAEAAVKEKEEGPEPRLTIDEAPQERLRE-TEASDPEEASQAQEDPGQGDQ-- 172
+R+ E +V + + + EA E L T SD + + G +
Sbjct: 169 RKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWK 228
Query: 173 QVCAEEADPELEPASGGEQ-----------------------------EPRPQQAQTKAA 203
++ A ++ E E GG+ + RP+ ++
Sbjct: 229 KMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESG 288
Query: 204 SQILENGEEAPGPDPSLD---------------RMLSSSSSVSSLNSSTLSGSQMSL--- 245
S + + + PG + ++ R + SS+ S +S + GS MS+
Sbjct: 289 S-LGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSE 347
Query: 246 SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA--RRRRSDPYVKSYLLPDK-- 301
+GD + V G + F+L YE L VHV +C LA A ++RS+PYVK+YLLPDK
Sbjct: 348 AGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSR 407
Query: 302 QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDT 361
Q KRKT++K+ +NP+++ETLRY +P++ L R L SVWH GRN FLGE E+ +D+
Sbjct: 408 QGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
Query: 362 WDWGSE-PTWLPLQPRV-PPSPDDLPS-RGLLALSLKYVPAGSEGAGLP-------PSGE 411
W + LPL ++ SP LPS +G L +SLKY+PA G GE
Sbjct: 468 WKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGE 527
Query: 412 LHFWVKEARDLLPLRA-GSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGF 470
L W+KEA++L +A G+ D++V+ ++LP ++AS+++T V++++L+P +NHT VY+G
Sbjct: 528 LQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGV 587
Query: 471 GPADLRQACAELSLWDHGALA-NRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALL 529
DL+ C EL++WD LA N LGG RL +GTG S G V WMDST EE LWQ +
Sbjct: 588 RLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMR 647
Query: 530 EQPCEWVDGLLPLRTNLA 547
+ P W +G L LR+++A
Sbjct: 648 QYPGSWAEGTLQLRSSMA 665
Score = 43.9 bits (102), Expect = 4e-04
Identities = 20/37 (54%), Positives = 29/37 (78%)
Query: 31 LLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67
LLDLSFL+EEE++ I VLQRD +R+ +E R+ +L+
Sbjct: 4 LLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLK 40
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 234 bits (597), Expect = 2e-61
Identities = 139/353 (39%), Positives = 211/353 (59%), Gaps = 36/353 (10%)
Query: 224 LSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAA 283
L+S S +SLNS S S +GD V+V G + + Y L + V C+ LA
Sbjct: 379 LASGLSTTSLNSMM---SVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAI 435
Query: 284 A--RRRRSDPYVKSYLLPDKQ--SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLS 339
+++R+D YVKSYLLPDK +KRKT ++ NP FNETL+Y++ +L+ R L LS
Sbjct: 436 GDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT-GTNPEFNETLKYTISHTQLETRTLQLS 494
Query: 340 VWHRESLGRNIFLGEVEVPLDTWDWGSEPT--WLPLQPRVPPSPD-DLPSRGLLALSLKY 396
VWH + GRN FLGEVE+P D+W++ PT W LQP+V +PD L +G L + L+Y
Sbjct: 495 VWHYDRFGRNSFLGEVEIPFDSWNF-ENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRY 553
Query: 397 VPAGSEGAGLPP---------------------SGELHFWVKEARDLLPLRA-GSLDTYV 434
+P E LPP G L ++KEA++L +++ G+ D++V
Sbjct: 554 IPP-EENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFV 612
Query: 435 QCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGAL-ANR 493
+ ++LPDDS+A++ +T V+++S++P +NHT ++ G P D++ C EL++WD A +N
Sbjct: 613 KGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNI 672
Query: 494 QLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNL 546
LGG RL+ G+G S+G V WMDS EE++LWQ + P +G+L LR+++
Sbjct: 673 FLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSM 725
Score = 39.7 bits (91), Expect = 0.007
Identities = 40/182 (21%), Positives = 81/182 (44%), Gaps = 21/182 (11%)
Query: 55 LRQLEEGRVS----KLRASVADP-GQLKILTGDWFQEARSQRHHNAH-FGSDLVRASMRR 108
LR E RV+ + +V D QL+I+TG+WF E +++R + G+D+VR S+ R
Sbjct: 86 LRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILR 145
Query: 109 KKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQER---LRETEASDPEEASQAQE 165
+S ++ ++ + A K + + P+ + L + ++ E +
Sbjct: 146 -RSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKT 204
Query: 166 DPGQG------DQQVCAEEADPELEPASGG-----EQEPRPQQAQTKAASQILENGEEAP 214
D G+ Q + ++ P + S G +QEP P+ ++ ++ + + +P
Sbjct: 205 DTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSP 264
Query: 215 GP 216
P
Sbjct: 265 AP 266
Score = 38.9 bits (89), Expect = 0.012
Identities = 17/36 (47%), Positives = 28/36 (77%)
Query: 32 LDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67
++LSFL + E+E I GVL+RD L+++E+ R+ KL+
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLK 43
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 234 bits (597), Expect = 2e-61
Identities = 139/353 (39%), Positives = 211/353 (59%), Gaps = 36/353 (10%)
Query: 224 LSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAA 283
L+S S +SLNS S S +GD V+V G + + Y L + V C+ LA
Sbjct: 379 LASGLSTTSLNSMM---SVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAI 435
Query: 284 A--RRRRSDPYVKSYLLPDKQ--SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLS 339
+++R+D YVKSYLLPDK +KRKT ++ NP FNETL+Y++ +L+ R L LS
Sbjct: 436 GDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT-GTNPEFNETLKYTISHTQLETRTLQLS 494
Query: 340 VWHRESLGRNIFLGEVEVPLDTWDWGSEPT--WLPLQPRVPPSPD-DLPSRGLLALSLKY 396
VWH + GRN FLGEVE+P D+W++ PT W LQP+V +PD L +G L + L+Y
Sbjct: 495 VWHYDRFGRNSFLGEVEIPFDSWNF-ENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRY 553
Query: 397 VPAGSEGAGLPP---------------------SGELHFWVKEARDLLPLRA-GSLDTYV 434
+P E LPP G L ++KEA++L +++ G+ D++V
Sbjct: 554 IPP-EENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFV 612
Query: 435 QCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGAL-ANR 493
+ ++LPDDS+A++ +T V+++S++P +NHT ++ G P D++ C EL++WD A +N
Sbjct: 613 KGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNI 672
Query: 494 QLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNL 546
LGG RL+ G+G S+G V WMDS EE++LWQ + P +G+L LR+++
Sbjct: 673 FLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSM 725
Score = 39.7 bits (91), Expect = 0.007
Identities = 40/182 (21%), Positives = 81/182 (44%), Gaps = 21/182 (11%)
Query: 55 LRQLEEGRVS----KLRASVADP-GQLKILTGDWFQEARSQRHHNAH-FGSDLVRASMRR 108
LR E RV+ + +V D QL+I+TG+WF E +++R + G+D+VR S+ R
Sbjct: 86 LRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILR 145
Query: 109 KKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQER---LRETEASDPEEASQAQE 165
+S ++ ++ + A K + + P+ + L + ++ E +
Sbjct: 146 -RSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKT 204
Query: 166 DPGQG------DQQVCAEEADPELEPASGG-----EQEPRPQQAQTKAASQILENGEEAP 214
D G+ Q + ++ P + S G +QEP P+ ++ ++ + + +P
Sbjct: 205 DTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSP 264
Query: 215 GP 216
P
Sbjct: 265 AP 266
Score = 38.9 bits (89), Expect = 0.012
Identities = 17/36 (47%), Positives = 28/36 (77%)
Query: 32 LDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67
++LSFL + E+E I GVL+RD L+++E+ R+ KL+
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLK 43
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 232 bits (591), Expect = 8e-61
Identities = 137/351 (39%), Positives = 209/351 (59%), Gaps = 36/351 (10%)
Query: 226 SSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA- 284
+ S +SLNS S S +GD V+V G + + Y L + V C+ LA
Sbjct: 403 ADSDTTSLNSMM---SVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGD 459
Query: 285 -RRRRSDPYVKSYLLPDKQ--SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVW 341
+++R+D YVKSYLLPDK +KRKT ++ NP FNETL+Y++ +L+ R L LSVW
Sbjct: 460 EKKQRTDAYVKSYLLPDKSRNNKRKTKIRT-GTNPEFNETLKYTISHTQLETRTLQLSVW 518
Query: 342 HRESLGRNIFLGEVEVPLDTWDWGSEPT--WLPLQPRVPPSPD-DLPSRGLLALSLKYVP 398
H + GRN FLGEVE+P D+W++ PT W LQP+V +PD L +G L + L+Y+P
Sbjct: 519 HYDRFGRNSFLGEVEIPFDSWNF-ENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIP 577
Query: 399 AGSEGAGLPP---------------------SGELHFWVKEARDLLPLRA-GSLDTYVQC 436
E LPP G L ++KEA++L +++ G+ D++V+
Sbjct: 578 P-EENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKG 636
Query: 437 FVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGAL-ANRQL 495
++LPDDS+A++ +T V+++S++P +NHT ++ G P D++ C EL++WD A +N L
Sbjct: 637 YLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFL 696
Query: 496 GGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNL 546
GG RL+ G+G S+G V WMDS EE++LWQ + P +G+L LR+++
Sbjct: 697 GGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSM 747
Score = 39.7 bits (91), Expect = 0.007
Identities = 40/182 (21%), Positives = 81/182 (44%), Gaps = 21/182 (11%)
Query: 55 LRQLEEGRVS----KLRASVADP-GQLKILTGDWFQEARSQRHHNAH-FGSDLVRASMRR 108
LR E RV+ + +V D QL+I+TG+WF E +++R + G+D+VR S+ R
Sbjct: 86 LRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILR 145
Query: 109 KKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQER---LRETEASDPEEASQAQE 165
+S ++ ++ + A K + + P+ + L + ++ E +
Sbjct: 146 -RSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKT 204
Query: 166 DPGQG------DQQVCAEEADPELEPASGG-----EQEPRPQQAQTKAASQILENGEEAP 214
D G+ Q + ++ P + S G +QEP P+ ++ ++ + + +P
Sbjct: 205 DTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSP 264
Query: 215 GP 216
P
Sbjct: 265 AP 266
Score = 38.9 bits (89), Expect = 0.012
Identities = 17/36 (47%), Positives = 28/36 (77%)
Query: 32 LDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67
++LSFL + E+E I GVL+RD L+++E+ R+ KL+
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLK 43
>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
Length = 542
Score = 181 bits (458), Expect = 2e-45
Identities = 166/545 (30%), Positives = 246/545 (45%), Gaps = 42/545 (7%)
Query: 32 LDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQR 91
+DLS L E E+EAI VL RD ++ EE R KL+ + DW + +
Sbjct: 5 IDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEHKEKCCA 64
Query: 92 HHNAHFGSDLVRASMRRKKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAP---QER 148
G L R ++ R S R A K + + I +ER
Sbjct: 65 RCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWFYEER 124
Query: 149 LRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILE 208
++ E Q Q Q++ P P Q R + A +
Sbjct: 125 AKKFPTGGKHETVGGQLL--QSYQKLSKISVVPPTPPPVSESQCSRSPGRKVSAPDILKP 182
Query: 209 NGEEAP--GPDPSLDRM-LSSSSSVSSLNSSTLS-GSQMSLS------GDAEAVQVRGSV 258
+E P +P L + L SS + S++ S GS +S+ G+ + V G +
Sbjct: 183 LNQEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEI 242
Query: 259 HFALHYEPGAAELRVHVIQCQGLAAA--RRRRSDPYVKSYLLPDK--QSKRKTAVKKRNL 314
FA+HY L + + C+ LA ++++ +PYVK+YLLPD+ Q KRKT V++ +
Sbjct: 243 EFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTV 302
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT----W 370
+P F ETL+Y V A+L R L +SVWH +L R +FLGEV +PL TWD+ T W
Sbjct: 303 DPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRW 362
Query: 371 LPLQPRVPPSPDDLP-SRGLLALSLKYV--------PAGSEGAGLPP-SGELHFWVKEAR 420
PL+ + D +P S G L + K V EG P G+L V A+
Sbjct: 363 HPLRAKAEKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAK 422
Query: 421 DLLPLRAGSLDTYVQ-CFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQAC 479
+L G+L+++V+ C LP D Q R ++ V+R+ P + H+ V+ G PA LRQ+
Sbjct: 423 NLPVRPDGTLNSFVKGCLTLP-DQQKLRLKSPVLRKQACPQWKHSFVFSGVTPAQLRQSS 481
Query: 480 AELSLWDHG--ALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVD 537
EL++WD + +R LGGTRL ++ G D+ K WQ +L P W D
Sbjct: 482 LELTVWDQALFGMNDRLLGGTRLGSKGDTAVG-----GDACSLSKLQWQKVLSSPNLWTD 536
Query: 538 GLLPL 542
L L
Sbjct: 537 MTLVL 541
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 121 bits (304), Expect = 1e-27
Identities = 87/291 (29%), Positives = 152/291 (52%), Gaps = 22/291 (7%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAARRR-RSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G + F+L Y+ A +L V V+Q L A SDPYVK +LLPDK+ K +T V ++ L
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTL 200
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSE-PTWLPL 373
NP FNET + VP EL G+ L ++++ + ++ +GEV+VP++T D G W L
Sbjct: 201 NPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDL 260
Query: 374 QPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSL-DT 432
Q P+ L G + SL+YVP +G+L + EA++L + G L D
Sbjct: 261 QGGEKEEPEKL---GDICTSLRYVPT---------AGKLTVCILEAKNLKKMDVGGLSDP 308
Query: 433 YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALAN 492
YV+ ++ + + +++T V +++L+P FN + ++ +++ +++ D+ L
Sbjct: 309 YVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGK 367
Query: 493 RQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQ---LWQALLEQPCEWVDGLL 540
+ G ++ +G+ ++ W D ++ W +L +P E VD LL
Sbjct: 368 NEAIG-KIFVGSNATGTELRHWSDMLANPRRPIAQWHSL--KPEEEVDALL 415
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 121 bits (304), Expect = 1e-27
Identities = 87/291 (29%), Positives = 152/291 (52%), Gaps = 22/291 (7%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAARRR-RSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G + F+L Y+ A +L V V+Q L A SDPYVK +LLPDK+ K +T V ++ L
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTL 200
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSE-PTWLPL 373
NP FNET + VP EL G+ L ++++ + ++ +GEV+VP++T D G W L
Sbjct: 201 NPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDL 260
Query: 374 QPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSL-DT 432
Q P+ L G + SL+YVP +G+L + EA++L + G L D
Sbjct: 261 QGGEKEEPEKL---GDICTSLRYVPT---------AGKLTVCILEAKNLKKMDVGGLSDP 308
Query: 433 YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALAN 492
YV+ ++ + + +++T V +++L+P FN + ++ +++ +++ D+ L
Sbjct: 309 YVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGK 367
Query: 493 RQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQ---LWQALLEQPCEWVDGLL 540
+ G ++ +G+ ++ W D ++ W +L +P E VD LL
Sbjct: 368 NEAIG-KIFVGSNATGTELRHWSDMLANPRRPIAQWHSL--KPEEEVDALL 415
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 120 bits (300), Expect = 4e-27
Identities = 84/265 (31%), Positives = 138/265 (52%), Gaps = 19/265 (7%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAARRR-RSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G + ++L Y+ + +L V ++Q GLAA SDPYV+ YLLPDK+ + +T V ++ L
Sbjct: 110 GRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTL 169
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSE-PTWLPL 373
NP F ET + VP EL GRVL ++V+ + RN +GEV VP+ + D G W L
Sbjct: 170 NPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWREL 229
Query: 374 QPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSL-DT 432
Q + L G + SL+YVP +G+L V EA++L + G L D
Sbjct: 230 QAAPREEQEKL---GDICFSLRYVPT---------AGKLTVIVLEAKNLKKMDVGGLSDP 277
Query: 433 YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPAD-LRQACAELSLWDHGALA 491
YV+ +L + +++T + + +L+P +N ++ P D +++ EL++ D+ L
Sbjct: 278 YVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFE--VPCDQVQKVQVELTVLDYDKLG 335
Query: 492 NRQLGGTRLSLGTGSSYGLQVPWMD 516
+ G R+++G + W D
Sbjct: 336 KNEAIG-RVAVGAAAGGAGLRHWAD 359
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 119 bits (297), Expect = 9e-27
Identities = 118/459 (25%), Positives = 188/459 (40%), Gaps = 38/459 (8%)
Query: 92 HHNAHFGSDLVRASMRRKKSTRGDQAP-----GHDREAEAAVKEKEEGPEPRLTIDEAPQ 146
HH+AH A + S G P D EAA G +P T E P
Sbjct: 131 HHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPS 190
Query: 147 ERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQI 206
E G G + + L P + PRP QT +
Sbjct: 191 E-------GGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPD 243
Query: 207 LENGEEAPG---PDPSLDRMLSSSSSVS-SLNSSTLSGSQMSL----SGDAEAVQVRGSV 258
+ E P P P + + L T G + S SG+A G +
Sbjct: 244 PSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRI 303
Query: 259 HFALHYEPGAAELRVHVIQCQGLAAARRRR-SDPYVKSYLLPDKQSKRKTAVKKRNLNPV 317
FAL Y G+ +L V ++Q L A SDPYVK YLLPD++ K +T V ++ LNPV
Sbjct: 304 SFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPV 363
Query: 318 FNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQPRV 377
FNET ++SVP AEL R L SV+ + R+ +G+V + + + +P PL +
Sbjct: 364 FNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLD-NLLELAEQPPDRPLWRDI 422
Query: 378 PPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPL-RAGSLDTYVQC 436
+ G L SL Y LP +G L + +A +L + G D YV+
Sbjct: 423 VEGGSEKADLGELNFSLCY---------LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKA 473
Query: 437 FVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALA-NRQL 495
++ + + +++T + + +L+P +N +V+D P + +++ D+ + N +
Sbjct: 474 SLISEGRRLKKRKTSIKKNTLNPTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVI 532
Query: 496 GGTRLSLGTGSSYGLQVPWMDSTPEEK---QLWQALLEQ 531
G R+ +G + W + + + W L+E+
Sbjct: 533 GVCRVGPDAADPHGRE-HWAEMLANPRKPVEHWHQLVEE 570
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 119 bits (297), Expect = 9e-27
Identities = 118/459 (25%), Positives = 188/459 (40%), Gaps = 38/459 (8%)
Query: 92 HHNAHFGSDLVRASMRRKKSTRGDQAP-----GHDREAEAAVKEKEEGPEPRLTIDEAPQ 146
HH+AH A + S G P D EAA G +P T E P
Sbjct: 131 HHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPS 190
Query: 147 ERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQI 206
E G G + + L P + PRP QT +
Sbjct: 191 E-------GGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPD 243
Query: 207 LENGEEAPG---PDPSLDRMLSSSSSVS-SLNSSTLSGSQMSL----SGDAEAVQVRGSV 258
+ E P P P + + L T G + S SG+A G +
Sbjct: 244 PSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRI 303
Query: 259 HFALHYEPGAAELRVHVIQCQGLAAARRRR-SDPYVKSYLLPDKQSKRKTAVKKRNLNPV 317
FAL Y G+ +L V ++Q L A SDPYVK YLLPD++ K +T V ++ LNPV
Sbjct: 304 SFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPV 363
Query: 318 FNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQPRV 377
FNET ++SVP AEL R L SV+ + R+ +G+V + + + +P PL +
Sbjct: 364 FNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLD-NLLELAEQPPDRPLWRDI 422
Query: 378 PPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPL-RAGSLDTYVQC 436
+ G L SL Y LP +G L + +A +L + G D YV+
Sbjct: 423 VEGGSEKADLGELNFSLCY---------LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKA 473
Query: 437 FVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALA-NRQL 495
++ + + +++T + + +L+P +N +V+D P + +++ D+ + N +
Sbjct: 474 SLISEGRRLKKRKTSIKKNTLNPTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVI 532
Query: 496 GGTRLSLGTGSSYGLQVPWMDSTPEEK---QLWQALLEQ 531
G R+ +G + W + + + W L+E+
Sbjct: 533 GVCRVGPDAADPHGRE-HWAEMLANPRKPVEHWHQLVEE 570
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 119 bits (297), Expect = 9e-27
Identities = 118/459 (25%), Positives = 188/459 (40%), Gaps = 38/459 (8%)
Query: 92 HHNAHFGSDLVRASMRRKKSTRGDQAP-----GHDREAEAAVKEKEEGPEPRLTIDEAPQ 146
HH+AH A + S G P D EAA G +P T E P
Sbjct: 131 HHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPS 190
Query: 147 ERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQI 206
E G G + + L P + PRP QT +
Sbjct: 191 E-------GGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPD 243
Query: 207 LENGEEAPG---PDPSLDRMLSSSSSVS-SLNSSTLSGSQMSL----SGDAEAVQVRGSV 258
+ E P P P + + L T G + S SG+A G +
Sbjct: 244 PSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRI 303
Query: 259 HFALHYEPGAAELRVHVIQCQGLAAARRRR-SDPYVKSYLLPDKQSKRKTAVKKRNLNPV 317
FAL Y G+ +L V ++Q L A SDPYVK YLLPD++ K +T V ++ LNPV
Sbjct: 304 SFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPV 363
Query: 318 FNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQPRV 377
FNET ++SVP AEL R L SV+ + R+ +G+V + + + +P PL +
Sbjct: 364 FNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLD-NLLELAEQPPDRPLWRDI 422
Query: 378 PPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPL-RAGSLDTYVQC 436
+ G L SL Y LP +G L + +A +L + G D YV+
Sbjct: 423 VEGGSEKADLGELNFSLCY---------LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKA 473
Query: 437 FVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALA-NRQL 495
++ + + +++T + + +L+P +N +V+D P + +++ D+ + N +
Sbjct: 474 SLISEGRRLKKRKTSIKKNTLNPTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVI 532
Query: 496 GGTRLSLGTGSSYGLQVPWMDSTPEEK---QLWQALLEQ 531
G R+ +G + W + + + W L+E+
Sbjct: 533 GVCRVGPDAADPHGRE-HWAEMLANPRKPVEHWHQLVEE 570
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 115 bits (287), Expect = 1e-25
Identities = 99/328 (30%), Positives = 156/328 (47%), Gaps = 28/328 (8%)
Query: 209 NGEEAPGPDP--SLDRMLSSSSSVSSLNSSTLSGSQMSLSGDAE-------AVQVRGSVH 259
N PG P DR SSVS L +S S M G E + + G +
Sbjct: 81 NTAPVPGQTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQ 140
Query: 260 FALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPDKQSKRKTAVKKRNLNPVF 318
F++ Y + L V +++ Q L A SDP+VK YLLPDK+ K +T VK++NLNP +
Sbjct: 141 FSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHW 200
Query: 319 NETLRY-SVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPT-WLPLQPR 376
NET + P ++ R+L L V + RN +GEV +PL+ D T W L+
Sbjct: 201 NETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLK-- 258
Query: 377 VPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLR-AGSLDTYVQ 435
P D SRG L LSL Y P+ + + + +AR+L + G+ D YV+
Sbjct: 259 --PCSDGSGSRGELLLSLCYNPS---------ANSIIVNIIKARNLKAMDIGGTSDPYVK 307
Query: 436 CFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQL 495
+++ D + +++T ++R+L+P+FN + +D LR+ +++ D L+ +
Sbjct: 308 VWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFD-IPTEKLRETTIIITVMDKDKLSRNDV 366
Query: 496 GGTRLSLGTGSSYGLQVPWMDSTPEEKQ 523
G ++ L S G W D +Q
Sbjct: 367 IG-KIYLSWKSGPGEVKHWKDMIARPRQ 393
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 110 bits (275), Expect = 3e-24
Identities = 68/216 (31%), Positives = 118/216 (54%), Gaps = 15/216 (6%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAARRR-RSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G + ++L Y+ +L V +IQ L A SDPYVK +LLPDK+ K +T V ++ L
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTL 203
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGS-EPTWLPL 373
NPVFNE + VP +EL G+ L ++V+ + ++ +GE +VP++T D+G W L
Sbjct: 204 NPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDL 263
Query: 374 QPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSL-DT 432
Q + L G + SL+YVP +G+L + EA++L + G L D
Sbjct: 264 QSAEKEEQEKL---GDICFSLRYVPT---------AGKLTVVILEAKNLKKMDVGGLSDP 311
Query: 433 YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD 468
YV+ ++ + + +++T + + +L+P +N + ++
Sbjct: 312 YVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Score = 64.3 bits (155), Expect = 3e-10
Identities = 37/115 (32%), Positives = 65/115 (56%), Gaps = 3/115 (2%)
Query: 246 SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPD--KQ 302
S + E + G + F+L Y P A +L V +++ + L SDPYVK +L+ + +
Sbjct: 265 SAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRL 324
Query: 303 SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEV 357
K+KT +KK LNP +NE+ + VP ++Q + ++V + +G+N +G+V V
Sbjct: 325 KKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 110 bits (275), Expect = 3e-24
Identities = 68/216 (31%), Positives = 118/216 (54%), Gaps = 15/216 (6%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAARRR-RSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G + ++L Y+ +L V +IQ L A SDPYVK +LLPDK+ K +T V ++ L
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTL 203
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGS-EPTWLPL 373
NPVFNE + VP +EL G+ L ++V+ + ++ +GE +VP++T D+G W L
Sbjct: 204 NPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDL 263
Query: 374 QPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSL-DT 432
Q + L G + SL+YVP +G+L + EA++L + G L D
Sbjct: 264 QSAEKEEQEKL---GDICFSLRYVPT---------AGKLTVVILEAKNLKKMDVGGLSDP 311
Query: 433 YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD 468
YV+ ++ + + +++T + + +L+P +N + ++
Sbjct: 312 YVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Score = 64.3 bits (155), Expect = 3e-10
Identities = 37/115 (32%), Positives = 65/115 (56%), Gaps = 3/115 (2%)
Query: 246 SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPD--KQ 302
S + E + G + F+L Y P A +L V +++ + L SDPYVK +L+ + +
Sbjct: 265 SAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRL 324
Query: 303 SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEV 357
K+KT +KK LNP +NE+ + VP ++Q + ++V + +G+N +G+V V
Sbjct: 325 KKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 110 bits (275), Expect = 3e-24
Identities = 68/216 (31%), Positives = 118/216 (54%), Gaps = 15/216 (6%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAARRR-RSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G + ++L Y+ +L V +IQ L A SDPYVK +LLPDK+ K +T V ++ L
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTL 203
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGS-EPTWLPL 373
NPVFNE + VP +EL G+ L ++V+ + ++ +GE +VP++T D+G W L
Sbjct: 204 NPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDL 263
Query: 374 QPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSL-DT 432
Q + L G + SL+YVP +G+L + EA++L + G L D
Sbjct: 264 QSAEKEEQEKL---GDICFSLRYVPT---------AGKLTVVILEAKNLKKMDVGGLSDP 311
Query: 433 YVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD 468
YV+ ++ + + +++T + + +L+P +N + ++
Sbjct: 312 YVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Score = 64.3 bits (155), Expect = 3e-10
Identities = 37/115 (32%), Positives = 65/115 (56%), Gaps = 3/115 (2%)
Query: 246 SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPD--KQ 302
S + E + G + F+L Y P A +L V +++ + L SDPYVK +L+ + +
Sbjct: 265 SAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRL 324
Query: 303 SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEV 357
K+KT +KK LNP +NE+ + VP ++Q + ++V + +G+N +G+V V
Sbjct: 325 KKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 104 bits (259), Expect = 2e-22
Identities = 79/264 (29%), Positives = 133/264 (50%), Gaps = 22/264 (8%)
Query: 242 QMSLSGD---AEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARR-RRSDPYVKSYL 297
Q S+ G+ +EA + G ++F+L Y+ L V +++ L A SDPYVK YL
Sbjct: 129 QKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYL 188
Query: 298 LPDKQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEV 357
LPD++ K +T V ++ LNP F+E + VP EL R L LSV+ + R+ +GEV +
Sbjct: 189 LPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVIL 248
Query: 358 P--LDTWDWGSEPT-WLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHF 414
+ D E + W +Q S D G + SL Y LP +G L
Sbjct: 249 DNLFEASDLSRETSIWKDIQYATSESVD----LGEIMFSLCY---------LPTAGRLTL 295
Query: 415 WVKEARDLLPLR-AGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPA 473
V + R+L + G D YV+ +L D + +++T + + +L+PV+N +++D P
Sbjct: 296 TVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFD-IPPE 354
Query: 474 DLRQACAELSLWDHGALANRQLGG 497
++ Q +S+ D+ + + ++ G
Sbjct: 355 NMDQVSLLISVMDYDRVGHNEIIG 378
Score = 66.6 bits (161), Expect = 6e-11
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPD--KQSKRKTAVKKR 312
G + F+L Y P A L + VI+C+ L A SDPYVK LL D + K+KT +KK
Sbjct: 278 GEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKN 337
Query: 313 NLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEV 357
LNPV+NE + + +P + L +SV + +G N +G V
Sbjct: 338 TLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRV 382
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 104 bits (259), Expect = 2e-22
Identities = 104/414 (25%), Positives = 183/414 (44%), Gaps = 35/414 (8%)
Query: 129 KEKEEGPEPRLTIDEAPQERLRETEASDPEEASQAQEDPGQGDQQVCAEEADPELEPASG 188
KE +E +P + E P ++ T P E A ++ +V + +P
Sbjct: 114 KEIKENEKPAVKAIE-PAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHS 172
Query: 189 GEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSGSQMSLSGD 248
+ P+Q Q + + + G +P L R +++S+ + + G+
Sbjct: 173 SFRRHLPRQMQVSSV-------DFSMGTEPVLQRG-ETTTSIGRIKPELYKQKSVDSEGN 224
Query: 249 A-EAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPDKQSKRK 306
E V++ G ++F L Y+ L V +I+ L A SDPYVK YLLPD++ K +
Sbjct: 225 QNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQ 284
Query: 307 TAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVP--LDTWDW 364
T V ++ LNP+F+ET ++ V +L R L SV+ + R+ +GEV + + D
Sbjct: 285 TRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDL 344
Query: 365 GSEPT-WLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLL 423
E T W + S D G + SL Y LP +G + V + R+L
Sbjct: 345 SREATVWKDIHCATTESID----LGEIMFSLCY---------LPTAGRMTLTVIKCRNLK 391
Query: 424 PLR-AGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAEL 482
+ GS D YV+ ++ + + +++T + +L+PV+N +++D P ++ Q +
Sbjct: 392 AMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFD-IPPENVDQVSLSI 450
Query: 483 SLWDHGALA-NRQLGGTRLSL---GTGSSYGLQVPWMDSTPEEKQLWQALLEQP 532
++ D+ + N +G R L G G + ++ P W LLE P
Sbjct: 451 AVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITH--WHPLLELP 502
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 101 bits (251), Expect = 2e-21
Identities = 74/246 (30%), Positives = 126/246 (51%), Gaps = 17/246 (6%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPDKQSKRKTAVKKRNL 314
G ++F L Y+ +L V + + L A SDPYVK YLLPD+++K +T V ++ L
Sbjct: 222 GKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTL 281
Query: 315 NPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVP--LDTWDWGSEPTWLP 372
NPVF+E + VP +L+ R L SV+ + R+ +G+V V LD D+ P
Sbjct: 282 NPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADF---PRECI 338
Query: 373 LQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLR-AGSLD 431
L + +D G L SL Y LP +G L + +AR+L + G+ D
Sbjct: 339 LWKDIEYVTNDNVDLGELMFSLCY---------LPTAGRLTITIIKARNLKAMDITGASD 389
Query: 432 TYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALA 491
YV+ ++ D + +++T R +L+PV+N +V+D P ++ Q +++ D+ +
Sbjct: 390 PYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFD-VPPENIDQIHLSIAVMDYDRVG 448
Query: 492 NRQLGG 497
+ ++ G
Sbjct: 449 HNEIIG 454
Score = 63.5 bits (153), Expect = 5e-10
Identities = 38/105 (36%), Positives = 58/105 (55%), Gaps = 3/105 (2%)
Query: 256 GSVHFALHYEPGAAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPD--KQSKRKTAVKKR 312
G + F+L Y P A L + +I+ + L A SDPYVK L+ D + KRKT+ K+
Sbjct: 354 GELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRN 413
Query: 313 NLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEV 357
LNPV+NE + + VP + LS++V + +G N +G +V
Sbjct: 414 TLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQV 458
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 96.7 bits (239), Expect = 5e-20
Identities = 98/364 (26%), Positives = 166/364 (45%), Gaps = 37/364 (10%)
Query: 208 ENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPG 267
E G G P+ L+ + + L ++T S D++ G++ F L Y+
Sbjct: 43 EGGGGGGGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRA 102
Query: 268 AAELRVHVIQCQGLAAAR-RRRSDPYVKSYLLPD--KQSKRKTAVKKRNLNPVFNETLRY 324
+ L +++ +GL +DPYVK +LLP K +K KT ++ LNPV+NE L Y
Sbjct: 103 SCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTY 162
Query: 325 S-VPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTW-LPLQPRVPPSPD 382
S + ++ +VL ++V + L N F+GE+ VPL + + + L+ +VP +
Sbjct: 163 SGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASP 222
Query: 383 DLPSRGLLALS--LKYVPAGSEGAGL-PPSGELHF---WVKEARDLLP--LRAGSL---- 430
S L +S LK + +G GL G + + R LL LR L
Sbjct: 223 SSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMD 282
Query: 431 -----DTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLW 485
D YV+ ++ PD + S+ +T V +++L+P FN Y+ + L E+++W
Sbjct: 283 VNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVW 341
Query: 486 DHG-ALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRT 544
D+ +N +GG +SLG G + E ++ W L+QP ++ L +
Sbjct: 342 DYDIGKSNDFIGG--VSLGPG-----------ARGEARKHWSDCLQQPDAALERWHTLTS 388
Query: 545 NLAP 548
L P
Sbjct: 389 ELPP 392
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,563,647
Number of Sequences: 37866
Number of extensions: 1279232
Number of successful extensions: 7368
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 497
Number of HSP's that attempted gapping in prelim test: 5662
Number of HSP's gapped (non-prelim): 1667
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.