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Search of human proteins with 9910362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9910362 semaphorin sem2 [Homo sapiens]
(782 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9910362 semaphorin sem2 [Homo sapiens] 1628 0.0
gi|6912650 semaphorin 3E [Homo sapiens] 771 0.0
gi|5174673 semaphorin 3A precursor [Homo sapiens] 699 0.0
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 662 0.0
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 659 0.0
gi|41406086 semaphorin 3D [Homo sapiens] 653 0.0
gi|188497703 semaphorin 3F [Homo sapiens] 623 e-178
gi|5454048 semaphorin 3C [Homo sapiens] 584 e-166
gi|157388902 semaphorin 4C [Homo sapiens] 319 5e-87
gi|28872814 semaphorin 4G [Homo sapiens] 315 8e-86
gi|39777610 semaphorin 4B precursor [Homo sapiens] 313 3e-85
gi|39777608 semaphorin 4B precursor [Homo sapiens] 313 3e-85
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 308 1e-83
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 297 2e-80
gi|19923279 semaphorin W [Homo sapiens] 276 5e-74
gi|21361914 semaphorin B [Homo sapiens] 263 6e-70
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 258 1e-68
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 254 3e-67
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 253 5e-67
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 253 5e-67
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 251 2e-66
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 250 4e-66
gi|19718780 semaphorin 6B precursor [Homo sapiens] 246 6e-65
gi|16306552 semaphorin Y [Homo sapiens] 232 9e-61
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 221 2e-57
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 208 1e-53
gi|147904700 semaphorin 5A [Homo sapiens] 191 3e-48
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 183 5e-46
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 181 2e-45
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 169 1e-41
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 1628 bits (4215), Expect = 0.0
Identities = 782/782 (100%), Positives = 782/782 (100%)
Query: 1 MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA 60
MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA
Sbjct: 1 MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA 60
Query: 61 MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV 120
MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV
Sbjct: 61 MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV 120
Query: 121 RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS 180
RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS
Sbjct: 121 RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS 180
Query: 181 TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDN 240
TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDN
Sbjct: 181 TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDN 240
Query: 241 DKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPG 300
DKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPG
Sbjct: 241 DKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPG 300
Query: 301 GAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHR 360
GAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHR
Sbjct: 301 GAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHR 360
Query: 361 DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRP 420
DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRP
Sbjct: 361 DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRP 420
Query: 421 RHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEV 480
RHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEV
Sbjct: 421 RHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEV 480
Query: 481 VLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYC 540
VLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYC
Sbjct: 481 VLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYC 540
Query: 541 AWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTF 600
AWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTF
Sbjct: 541 AWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTF 600
Query: 601 LECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEH 660
LECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEH
Sbjct: 601 LECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEH 660
Query: 661 GFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLP 720
GFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLP
Sbjct: 661 GFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLP 720
Query: 721 RVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVE 780
RVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVE
Sbjct: 721 RVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVE 780
Query: 781 AT 782
AT
Sbjct: 781 AT 782
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 771 bits (1992), Expect = 0.0
Identities = 395/786 (50%), Positives = 525/786 (66%), Gaps = 25/786 (3%)
Query: 1 MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA 60
MA + I LL G LL + G + + PRLRLS+++LL+ NR++IF P G L+L
Sbjct: 1 MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHT 60
Query: 61 MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV 120
M LDEY++RLF+GG D +YSL L++ +E+ WP + EEC+ KG+D ECAN+V
Sbjct: 61 MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDA-GECANYV 119
Query: 121 RVLQPHNRTHLLACGTGAFQPTCALITVG-HRGEHVLHLEPGSVESGRGRCPHEPSRPFA 179
RVL +NRTHLL CGTGAF P CA I VG H + + HLE E GRGRCP +PS F
Sbjct: 120 RVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFI 179
Query: 180 STFIDGELYTGLTADFLGREAMIFRSGGPRPALRSD-SDQSLLHDPRFVMAARIPENSDQ 238
ST I EL+ GL +D+ R+A IFRS G +R++ D+ LL +P+FV + IP+N D+
Sbjct: 180 STLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDR 239
Query: 239 DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPG 298
D++KVYFFF+E + + H +RVGR+CVND GGQR+LVNKWSTFLKARLVCSVPG
Sbjct: 240 DDNKVYFFFTEKALEAENNA-HAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPG 298
Query: 299 PGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFA 358
G +T+FD+LEDVFLL + K+ ++ LF+T S +F+G A+CVYHM+ I FNGP+A
Sbjct: 299 MNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYA 358
Query: 359 HRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPV 418
H++GP++ W Y GKVP+PRPG C SK+ G +G+TKDYPD+ ++FAR+HPLM+ +
Sbjct: 359 HKEGPEYHWSVYEGKVPYPRPGSCASKVN---GGRYGTTKDYPDDAIRFARSHPLMYQAI 415
Query: 419 RPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPE 478
+P H +P+LVKT L QI VDRVEAEDG YDV+F+GTD+G VLKVI + E
Sbjct: 416 KPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESME 475
Query: 479 EVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDP 538
EV+LEELQ+FK P PI MEIS KRQ LY+GS VAQ+R H C+ YG+ACA+CCLARDP
Sbjct: 476 EVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDP 535
Query: 539 YCAWDGASCTHYRP--SLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEH 596
YCAWDG SC+ Y P + KRRFRRQD+RHGN A QC GQ +A+ + YG E+
Sbjct: 536 YCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIEN 595
Query: 597 NSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCT 656
NST LEC P+S QA V W +Q+ + ++VKTD+RV+ + GLLF RL + DAGTY C
Sbjct: 596 NSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQ 655
Query: 657 TLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEP-----PARGGLASTPPKAWYKDIL 711
T+EH F TV ++ L V+ +++++F + + + PA+ + S K WYK+ L
Sbjct: 656 TVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSI-SQGAKPWYKEFL 714
Query: 712 QLIGFANLPRVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAE 771
QLIG++N RV+EYCE+VWC R R + K + K KK++S+ E
Sbjct: 715 QLIGYSNFQRVEEYCEKVWCTD--------RKRKKLKMSPSKWKYANPQEKKLRSK--PE 764
Query: 772 HNRTPR 777
H R PR
Sbjct: 765 HYRLPR 770
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 699 bits (1804), Expect = 0.0
Identities = 358/776 (46%), Positives = 497/776 (64%), Gaps = 15/776 (1%)
Query: 8 ICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYR 67
I L G+LL ++ + +VPRL+LSY+++L +N F G S + LDE R
Sbjct: 7 IVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER 66
Query: 68 DRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHN 127
RL++G D ++S L D ++++WP +R+EC G+D L ECANF++VL+ +N
Sbjct: 67 SRLYVGAKDHIFSFDLVNI-KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYN 125
Query: 128 RTHLLACGTGAFQPTCALITVGHRGE-HVLHLEPGSVESGRGRCPHEPSRPFASTFIDGE 186
+THL ACGTGAF P C I +GH E ++ LE E+GRG+ P++P AS IDGE
Sbjct: 126 QTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGE 185
Query: 187 LYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDPRFVMAARIPENSDQDNDKVYF 245
LY+G ADF+GR+ IFR+ G +R++ D L+DP+F+ A I E+ + ++DKVYF
Sbjct: 186 LYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYF 245
Query: 246 FFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETH 305
FF E + S T +R+G++C ND GG R LVNKW+TFLKARL+CSVPGP G +TH
Sbjct: 246 FFRENAIDGEH-SGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTH 304
Query: 306 FDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQH 365
FD+L+DVFL+ K K+ VY +F+T S +F+G AVC+Y M+D+ VF GP+AHRDGP +
Sbjct: 305 FDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNY 364
Query: 366 QWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRP 425
QW PY G+VP+PRPG CPSK F STKD PD+V+ FAR+HP M+ PV P + RP
Sbjct: 365 QWVPYQGRVPYPRPGTCPSKTFG----GFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP 420
Query: 426 VLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEEL 485
+++KT + Q QIVVDRV+AEDG YDV+F+GTD G+VLKV+++ + EEV+LEE+
Sbjct: 421 IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM 480
Query: 486 QVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGA 545
VF+ PT I+ ME+S K+Q LY+GS GVAQL LH+C+ YG ACAECCLARDPYCAWDG+
Sbjct: 481 TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS 540
Query: 546 SCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLP 605
+C+ Y P+ KRR RRQDIR+G+P C + ++YG E++STFLEC P
Sbjct: 541 ACSRYFPT-AKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSP 599
Query: 606 KSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQT 665
KS +A V W QR +E ++++ D+ ++ T++GLL R L + D+G Y C +EHGF QT
Sbjct: 600 KSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQT 659
Query: 666 VVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPP--KAWYKDILQLIGFANLPRVD 723
++++ L VI L+ L + + + S P K WY+D +QLI NL +D
Sbjct: 660 LLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMD 719
Query: 724 EYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREV 779
E+CE+VW R + R R W L+ KK ++R E R PR V
Sbjct: 720 EFCEQVWKRDRKQ----RRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV 771
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 662 bits (1709), Expect = 0.0
Identities = 351/711 (49%), Positives = 457/711 (64%), Gaps = 31/711 (4%)
Query: 7 AICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEY 66
A+ W +G GS+ PSP PRLRLS+++L + + F + + QA+ +DE
Sbjct: 14 ALLWAVGL-----GSAAPSP----PRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEE 63
Query: 67 RDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPH 126
R RLF+G + + SL LD +++ WP REEC G+D TEC NFV++L +
Sbjct: 64 RGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAY 123
Query: 127 NRTHLLACGTGAFQPTCALITVGHRGEH-VLHLEPGSVESGRGRCPHEPSRPFASTFIDG 185
NRTHLLACGTGAF PTCA + VGHR E VL L+PG +E G+G+ P++P AS +
Sbjct: 124 NRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE 183
Query: 186 ELYTGLTADFLGREAMIFRSGGPRPALRSD-SDQSLLHDPRFVMAARIPENSDQDNDKVY 244
ELY+G+ AD +GR+ IFRS G RP+LR++ D L++P+FV IPE+ + D+DK+Y
Sbjct: 184 ELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIY 243
Query: 245 FFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAET 304
FFF ET ++VSRVG++C ND GGQR LVNKW+TFLKARLVCSVPG G +T
Sbjct: 244 FFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DT 302
Query: 305 HFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQ 364
HFDQL+DVFLL + ++ +YA+FST S++FQG AVCVY M D+ F GPFAH++GP
Sbjct: 303 HFDQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPM 362
Query: 365 HQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGR 424
HQW Y G+VP+PRPG+CPSK F STKD+PD+V+QFAR HPLM+ V P GR
Sbjct: 363 HQWVSYQGRVPYPRPGMCPSKTFG----TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGR 418
Query: 425 PVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEE 484
P+ ++ QI DRV A DG YDV+F+GTD G+VLKVI++ G E ++LEE
Sbjct: 419 PLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEE 478
Query: 485 LQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDG 544
L VF+ +T M+IS KR LYV SR VAQ+ LH+C +G C ECCLARDPYCAWDG
Sbjct: 479 LHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDG 538
Query: 545 ASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECL 604
+CT ++PS KRRFRRQD+R+G+P+ C G S + V+G E +S FLEC
Sbjct: 539 VACTRFQPS-AKRRFRRQDVRNGDPSTLCSGDSSRP----ALLEHKVFGVEGSSAFLECE 593
Query: 605 PKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQ 664
P+S QA V W QR G QV +ER T RGLL RRL R D+G Y C +E GF+Q
Sbjct: 594 PRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQ 653
Query: 665 TVVRLALVVIVASQLDNLF-PPEPKPEEPPARGGLASTPPKAWYKDILQLI 714
+ RL+L V+ A+Q + L E P PP PK WY+D LQL+
Sbjct: 654 PLRRLSLHVLSATQAERLARAEEAAPAAPPG--------PKLWYRDFLQLV 696
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 659 bits (1699), Expect = 0.0
Identities = 351/711 (49%), Positives = 457/711 (64%), Gaps = 32/711 (4%)
Query: 7 AICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEY 66
A+ W +G GS+ PSP PRLRLS+++L + + F + + QA+ +DE
Sbjct: 14 ALLWAVGL-----GSAAPSP----PRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEE 63
Query: 67 RDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPH 126
R RLF+G + + SL LD +++ WP REEC G+D TEC NFV++L +
Sbjct: 64 RGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAY 123
Query: 127 NRTHLLACGTGAFQPTCALITVGHRGEH-VLHLEPGSVESGRGRCPHEPSRPFASTFIDG 185
NRTHLLACGTGAF PTCA + VGHR E VL L+PG +E G+G+ P++P AS +
Sbjct: 124 NRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE 183
Query: 186 ELYTGLTADFLGREAMIFRSGGPRPALRSD-SDQSLLHDPRFVMAARIPENSDQDNDKVY 244
ELY+G+ AD +GR+ IFRS G RP+LR++ D L++P+FV IPE+ + D+DK+Y
Sbjct: 184 ELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIY 243
Query: 245 FFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAET 304
FFF ET ++VSRVG++C ND GGQR LVNKW+TFLKARLVCSVPG G +T
Sbjct: 244 FFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DT 302
Query: 305 HFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQ 364
HFDQL+DVFLL + ++ +YA+FST S++FQG AVCVY M D+ F GPFAH++GP
Sbjct: 303 HFDQLQDVFLLSSRDHRTPLLYAVFST-SSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPM 361
Query: 365 HQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGR 424
HQW Y G+VP+PRPG+CPSK F STKD+PD+V+QFAR HPLM+ V P GR
Sbjct: 362 HQWVSYQGRVPYPRPGMCPSKTFG----TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGR 417
Query: 425 PVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEE 484
P+ ++ QI DRV A DG YDV+F+GTD G+VLKVI++ G E ++LEE
Sbjct: 418 PLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEE 477
Query: 485 LQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDG 544
L VF+ +T M+IS KR LYV SR VAQ+ LH+C +G C ECCLARDPYCAWDG
Sbjct: 478 LHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDG 537
Query: 545 ASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECL 604
+CT ++PS KRRFRRQD+R+G+P+ C G S + V+G E +S FLEC
Sbjct: 538 VACTRFQPS-AKRRFRRQDVRNGDPSTLCSGDSSRP----ALLEHKVFGVEGSSAFLECE 592
Query: 605 PKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQ 664
P+S QA V W QR G QV +ER T RGLL RRL R D+G Y C +E GF+Q
Sbjct: 593 PRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQ 652
Query: 665 TVVRLALVVIVASQLDNLF-PPEPKPEEPPARGGLASTPPKAWYKDILQLI 714
+ RL+L V+ A+Q + L E P PP PK WY+D LQL+
Sbjct: 653 PLRRLSLHVLSATQAERLARAEEAAPAAPPG--------PKLWYRDFLQLV 695
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 653 bits (1685), Expect = 0.0
Identities = 344/760 (45%), Positives = 491/760 (64%), Gaps = 34/760 (4%)
Query: 29 SVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWP 88
++PRL+L+Y+DLL +N FLG L+ Q + LDE R RL LG D ++ L L
Sbjct: 41 NIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNK 100
Query: 89 DPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITV 148
+ +++ WP + E C G+D TECANF+RVLQP+N+TH+ CGTGAF P C I +
Sbjct: 101 NFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDL 160
Query: 149 G-HRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGG 207
G ++ + + L+ ++ESGR +CP +P +PFAS D LY+G +DFLG++ RS G
Sbjct: 161 GVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLG 220
Query: 208 P---RPALRSD-SDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTV 263
P +R+D S+ L+ +F+ IP+ + D+DK+YFFF E+ S +G ++ T+
Sbjct: 221 PTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRES--SQEGSTSDKTI 278
Query: 264 -SRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKS 322
SRVGRVC ND GGQR L+NKW+TFLKARL+CS+PG GA+T+FD+L+D++LL + ++
Sbjct: 279 LSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERN 338
Query: 323 LEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVC 382
VY +F+T S++F+G AVCVY MADI VFNGP+AH++ H+W Y G++P+PRPG C
Sbjct: 339 PVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC 398
Query: 383 PSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVD 442
PSK T P ST+D+PD+V+ F + H +M+ V P G P + ++ +L QIVVD
Sbjct: 399 PSK-TYDP--LIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVD 455
Query: 443 RVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVK 502
V AEDG YDV+FLGTD G+VLKV+++ + EEVVLEELQ+FK + I ME+S+K
Sbjct: 456 HVIAEDGQYDVMFLGTDIGTVLKVVSI-SKEKWNMEEVVLEELQIFKHSSIILNMELSLK 514
Query: 503 RQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQ 562
+Q LY+GSR G+ QL LH+C+TYG ACA+CCLARDPYCAWDG +C+ Y P+ KRR RRQ
Sbjct: 515 QQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPT-SKRRARRQ 573
Query: 563 DIRHGNPALQCLGQSQEEEAVGLVAA--TMVYGTEHNSTFLECLPKSPQAAVRWLLQRPG 620
D+++G+P QC E+++ A +++G E NSTFLEC+PKS QA ++W +QR G
Sbjct: 574 DVKYGDPITQCW---DIEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSG 630
Query: 621 DEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLD 680
DE +++K DER++ TE GLL R L + D+G Y C EH F T+V+L L VI Q++
Sbjct: 631 DEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQME 690
Query: 681 NLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLPRVDEYCERVWCRGTTECSGC 740
N + EE + LA + + YKD +Q++ N +D+YCE++W
Sbjct: 691 N--TQRAEHEEGKVKDLLAES--RLRYKDYIQILSSPNF-SLDQYCEQMW---------- 735
Query: 741 FRSRSRGKQARGKSWAGL-ELGKKMKSRVHAEHNRTPREV 779
R + R + G W + E+ KK R H + + PR V
Sbjct: 736 HREKRRQRNKGGPKWKHMQEMKKKRNRRHHRDLDELPRAV 775
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 623 bits (1607), Expect = e-178
Identities = 325/737 (44%), Positives = 450/737 (61%), Gaps = 47/737 (6%)
Query: 28 PSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAW 87
P+ PR+RLS+++L + + F + + + + DE DR+++G D + SL L
Sbjct: 27 PATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDIN 86
Query: 88 PDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALIT 147
+P + W P + EECV G+D EC NFVR++QP NRTHL CGTGA+ P C +
Sbjct: 87 REPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVN 146
Query: 148 VGHRGE--------------------------------HVLHLEPGSVESGRGRCPHEPS 175
G R + ++ +LEP +ESG+G+CP++P
Sbjct: 147 RGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPK 206
Query: 176 RPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAARIPE 234
AS I+ ELY G+ DF+G +A IFR+ G + A+R+D S L+DP F+ A IP+
Sbjct: 207 LDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPD 266
Query: 235 NSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVC 294
++++++DK+YFFF E S + + +R+GR+C+ND GG LVNKWSTFLKARLVC
Sbjct: 267 SAERNDDKLYFFFRER--SAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVC 324
Query: 295 SVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFN 354
SVPG G ETHFD+L+DVF+ + ++ +YA+F++ +VF+G AVCVY MADI VFN
Sbjct: 325 SVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFN 384
Query: 355 GPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLM 414
GPFAH++GP +QW P+ GK+P+PRPG CP T P STKDYPDEV+ F R+HPLM
Sbjct: 385 GPFAHKEGPNYQWMPFSGKMPYPRPGTCPGG-TFTPS--MKSTKDYPDEVINFMRSHPLM 441
Query: 415 FWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGS 474
+ V P RP++V+T +L I VD+V+A DG Y+V+FLGTD G+V KVI L
Sbjct: 442 YQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPK-DD 500
Query: 475 AEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCL 534
E EE++LEE++VFK P P+ M IS KRQ LYV S +GV L LH+C+ YG ACA+CCL
Sbjct: 501 QELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCL 560
Query: 535 ARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGT 594
ARDPYCAWDG +C+ Y S KRR RRQD+RHGNP QC G + A ++ YG
Sbjct: 561 ARDPYCAWDGQACSRYTAS-SKRRSRRQDVRHGNPIRQCRGFN--SNANKNAVESVQYGV 617
Query: 595 EHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYT 654
++ FLEC P+SPQA V+WL QR + +++ ++R L TE+GLL R L D G Y+
Sbjct: 618 AGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYS 677
Query: 655 CTTLEHGFSQTVVRLALVVIVASQLD-NLFPPEPKPEEPPARGGLASTPPKAWYKDILQL 713
CT E+ F V R+ L V+ + LFPP PP G PP Y+++ QL
Sbjct: 678 CTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGAG----PPTPPYQELAQL 733
Query: 714 IGFANLPRVDEYCERVW 730
+ + + +YC+ W
Sbjct: 734 LAQPEVGLIHQYCQGYW 750
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 584 bits (1505), Expect = e-166
Identities = 308/671 (45%), Positives = 418/671 (62%), Gaps = 18/671 (2%)
Query: 8 ICWLLGGLLLH---GGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLD 64
IC L+G + GSS P R+ L++ +L S F L+ + + +D
Sbjct: 6 ICVLVGVFICSICVKGSSQPQA-----RVYLTFDELRETKTSEYFSLSHHPLDYRILLMD 60
Query: 65 EYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQ 124
E +DR+++G D + SL ++ + V WP + EEC G+DP C NFVRV+Q
Sbjct: 61 EDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQ 120
Query: 125 PHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFID 184
NRTHL CG+GAF P C + G R E + + ESG+GRC P+ S I+
Sbjct: 121 TFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMIN 180
Query: 185 GELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAARIPENSDQDNDKV 243
EL++G+ DF+G +A IFRS R A+R+D S L +P FV A IP+ +D ++ KV
Sbjct: 181 EELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKV 240
Query: 244 YFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAE 303
YFFF E + + + + S + R+C ND GG R LVNKW+TFLKARLVCSV G E
Sbjct: 241 YFFFKEKLTDNNRSTKQIH-SMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPE 299
Query: 304 THFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGP 363
THFD+LEDVFLL ++ VY +F+T S+VF+G AVCVYH++DI VFNGPFAH++GP
Sbjct: 300 THFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGP 359
Query: 364 QHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHG 423
HQ Y G++P+PRPG CP R +TK++PD+V+ F R HPLM+ + P H
Sbjct: 360 NHQLISYQGRIPYPRPGTCPGGAFTPNMR---TTKEFPDDVVTFIRNHPLMYNSIYPIHK 416
Query: 424 RPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLE 483
RP++V+ + +I VDRV A DG Y V+FLGTD G+V KV+ L S E++LE
Sbjct: 417 RPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSVS-GELILE 475
Query: 484 ELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWD 543
EL+VFK PIT M+IS K+Q LYV S GV+Q+ LH+C YGTACA+CCLARDPYCAWD
Sbjct: 476 ELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWD 535
Query: 544 GASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLEC 603
G SC+ + P+ GKRR RRQD+RHGNP QC G + +A A + YG ++N+TFLEC
Sbjct: 536 GHSCSRFYPT-GKRRSRRQDVRHGNPLTQCRGFNL--KAYRNAAEIVQYGVKNNTTFLEC 592
Query: 604 LPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFS 663
PKSPQA+++WLLQ+ D +VK +ER++ T +GLL R + D G Y C E+ F
Sbjct: 593 APKSPQASIKWLLQKDKDR-RKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFK 651
Query: 664 QTVVRLALVVI 674
QT+ ++ V+
Sbjct: 652 QTIAKINFKVL 662
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 319 bits (818), Expect = 5e-87
Identities = 231/690 (33%), Positives = 335/690 (48%), Gaps = 57/690 (8%)
Query: 1 MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA 60
MAP WA+ WLL L G VPR +S +L + R G Q L L
Sbjct: 1 MAPH-WAV-WLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLT- 57
Query: 61 MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV 120
L E L++G +AL++ ++ A + W ++ EC++KG++ TEC NF+
Sbjct: 58 --LTEPTGLLYVGAREALFAFSME-ALELQGAISWEAPVEKKTECIQKGKNNQTECFNFI 114
Query: 121 RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS 180
R LQP+N +HL CGT AFQP C + + LE G E G+G+CP++P++ A
Sbjct: 115 RFLQPYNASHLYVCGTYAFQPKCTYVNM-----LTFTLEHGEFEDGKGKCPYDPAKGHAG 169
Query: 181 TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQ-- 238
+DGELY+ +FLG E +I R+ GP +++++ L++P FV +A +PE+
Sbjct: 170 LLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFT 229
Query: 239 -DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVP 297
D+DKVYFFF E D + V V+RV RVC D GG R L KW+TFLKARL CS P
Sbjct: 230 GDDDKVYFFFRERAVESDCYAEQV-VARVARVCKGDMGGARTLQRKWTTFLKARLACSAP 288
Query: 298 GPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPF 357
+ +F+QL+ + L + + + +F A+C Y + +I VF GP+
Sbjct: 289 ---NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPY 345
Query: 358 AHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWP 417
+W Y VP PRPG C + + G + S+ + PD +L F + HPLM
Sbjct: 346 KEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHG--YTSSLELPDNILNFVKKHPLMEEQ 403
Query: 418 VRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVLKVIALQAGGSAE 476
V PR RP+LVK +V DRV DG TY V+F+GT G +LK ++L
Sbjct: 404 VGPRWSRPLLVKK--GTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSL------G 455
Query: 477 PEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLAR 536
P ++EELQ+F P+ + +S +++L+ GSR + QL + C Y +CA+C LAR
Sbjct: 456 PWVHLIEELQLFD-QEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLAR 513
Query: 537 DPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEH 596
DPYCAW S+ R G+ +Q + S L + V T
Sbjct: 514 DPYCAW----------SVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPK 563
Query: 597 NST-------FLECLPKSPQAAVRWLL---QRPGDEGPDQVKTDERVLHTERGLLFRRLS 646
N T L C S A RW P ++ P D R+ + L+
Sbjct: 564 NITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQ-PGSFLYDARL----QALVVMAAQ 618
Query: 647 RFDAGTYTCTTLEHGFSQTVVRLALVVIVA 676
AG Y C + E G ++ LV +VA
Sbjct: 619 PRHAGAYHCFSEEQG-ARLAAEGYLVAVVA 647
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 315 bits (808), Expect = 8e-86
Identities = 239/737 (32%), Positives = 333/737 (45%), Gaps = 75/737 (10%)
Query: 6 WAICWLLGGLLLHGGSSGPSPGPSV----------PRLRLSYRDLLSANRSAIFLGPQGS 55
W W LLL ++ PGPS+ PR+ + Y +L F G +
Sbjct: 2 WGRLW---PLLLSILTATAVPGPSLRRPSRELDATPRMTIPYEELSGTRH---FKGQ--A 53
Query: 56 LNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP-REVLWPPQPGQREECVRKGRDPLT 114
N + L+E RL +G AL+SL + +E+ W P + +C +KG++ T
Sbjct: 54 QNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQT 113
Query: 115 ECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEP 174
EC N VR LQ N THL ACGT AFQP CA I + P S E G+ +CP++P
Sbjct: 114 ECFNHVRFLQRLNSTHLYACGTHAFQPLCAAI------DAEAFTLPTSFEEGKEKCPYDP 167
Query: 175 SRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPE 234
+R F IDG LYT +F I RS P ++ L+D FV + + E
Sbjct: 168 ARGFTGLIIDGGLYTATRYEFRSIPD-IRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRE 226
Query: 235 NSDQ---DNDKVYFFFSETVPSPDGGS-----NHVTVSRVGRVCVNDAGGQRVLVNKWST 286
+ D+DKVY+FF+E GS + V+RV RVC D GG+++L KW++
Sbjct: 227 SKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTS 286
Query: 287 FLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALF--STVSAVFQGFAVCVY 344
FLKARL+C +P ++ L V L + YA F ST + A+C Y
Sbjct: 287 FLKARLICHIP-------LYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAICRY 339
Query: 345 HMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEV 404
+A+I VF GP+ +WG Y G VP PRPG C + G + S++D P V
Sbjct: 340 DLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQG--YNSSQDLPSLV 397
Query: 405 LQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVL 464
L F + HPLM PV P GRP+L+K ++ + H TYD++FLGT G +
Sbjct: 398 LDFVKLHPLMARPVVPTRGRPLLLKRNI-RYTHLTGTPVTTPAGPTYDLLFLGTADGWIH 456
Query: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524
K + L +G ++EE QVF+ + + IS+ + LYVG+ GV QL L C
Sbjct: 457 KAVVLGSGMH------IIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSR 510
Query: 525 YGTACAECCLARDPYCAWD------GASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQ 578
Y +C +C LARDPYC WD A+ T S G R QDI GN C
Sbjct: 511 Y-RSCYDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRG--CESSRD 567
Query: 579 EEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTER 638
L +++ G + L C S A WLL G G + RV
Sbjct: 568 TGPPPPLKTRSVLRG---DDVLLPCDQPSNLARALWLLN--GSMGLSDGQGGYRV--GVD 620
Query: 639 GLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGL 698
GLL +G Y C E+G + +L V A+ P P P+ P G
Sbjct: 621 GLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLTVRPAT-------PAPAPKAPATPGAQ 673
Query: 699 ASTPPKAWYKDILQLIG 715
+ + Y + +G
Sbjct: 674 LAPDVRLLYVLAIAALG 690
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 313 bits (803), Expect = 3e-85
Identities = 222/645 (34%), Positives = 320/645 (49%), Gaps = 50/645 (7%)
Query: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAW---PDPREVLWPPQPGQREECVRKGRDPL 113
N A+ L L++G +AL++L + ++ + +E+LW ++++C KG+DP
Sbjct: 69 NYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQ 128
Query: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSV--ESGRGRCP 171
+C N++++L P + +HL CGT AF P C I + + E G+V E G+GRCP
Sbjct: 129 RDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINM--ENFTLARDEKGNVLLEDGKGRCP 186
Query: 172 HEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAAR 231
+P+ + +DGELYTG + F G + I RS RP +++S + L DP FV +A
Sbjct: 187 FDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQDPAFVASAY 245
Query: 232 IPENSDQ---DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFL 288
IPE+ D+DK+YFFFSET + N + VSR+ R+C D GG+RVL +W++FL
Sbjct: 246 IPESLGSLQGDDDKIYFFFSETGQEFEFFENTI-VSRIARICKGDEGGERVLQQRWTSFL 304
Query: 289 KARLVCSVPGPGGAETHFDQLEDVFLL--WPKAGKSLEVYALFSTV--SAVFQGFAVCVY 344
KA+L+CS P G F+ L+DVF L P+ + Y +F++ +G AVCV+
Sbjct: 305 KAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVF 361
Query: 345 HMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEV 404
M D+ VF+G + + QW VP PRPG C + + R S+ PD V
Sbjct: 362 TMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARE--RKINSSLQLPDRV 419
Query: 405 LQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVL 464
L F + H LM VR R +L++ Q ++ V RV TYDV+FLGT G +
Sbjct: 420 LNFLKDHFLMDGQVR---SRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLH 474
Query: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524
K + S P ++EELQ+F P+ + + R +LY S GV Q+ + C
Sbjct: 475 KAV------SVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSL 528
Query: 525 YGTACAECCLARDPYCAWDGASCTH---YRPSLGKRRFRRQDIRHGNPALQCLGQSQEEE 581
Y +C +C LARDPYCAW G+SC H Y+P L R + QDI + C S
Sbjct: 529 Y-RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPW-IQDIEGASAKDLCSASSVVSP 586
Query: 582 A---VGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTER 638
+ G V + L C S A WL R G P VL T
Sbjct: 587 SFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNG--APVNASASCHVLPTGD 642
Query: 639 GLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVI---VASQLD 680
LL + G + C +LE GF Q V V+ VA Q D
Sbjct: 643 LLL---VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD 684
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 313 bits (803), Expect = 3e-85
Identities = 222/645 (34%), Positives = 320/645 (49%), Gaps = 50/645 (7%)
Query: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAW---PDPREVLWPPQPGQREECVRKGRDPL 113
N A+ L L++G +AL++L + ++ + +E+LW ++++C KG+DP
Sbjct: 69 NYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQ 128
Query: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSV--ESGRGRCP 171
+C N++++L P + +HL CGT AF P C I + + E G+V E G+GRCP
Sbjct: 129 RDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINM--ENFTLARDEKGNVLLEDGKGRCP 186
Query: 172 HEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAAR 231
+P+ + +DGELYTG + F G + I RS RP +++S + L DP FV +A
Sbjct: 187 FDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQDPAFVASAY 245
Query: 232 IPENSDQ---DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFL 288
IPE+ D+DK+YFFFSET + N + VSR+ R+C D GG+RVL +W++FL
Sbjct: 246 IPESLGSLQGDDDKIYFFFSETGQEFEFFENTI-VSRIARICKGDEGGERVLQQRWTSFL 304
Query: 289 KARLVCSVPGPGGAETHFDQLEDVFLL--WPKAGKSLEVYALFSTV--SAVFQGFAVCVY 344
KA+L+CS P G F+ L+DVF L P+ + Y +F++ +G AVCV+
Sbjct: 305 KAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVF 361
Query: 345 HMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEV 404
M D+ VF+G + + QW VP PRPG C + + R S+ PD V
Sbjct: 362 TMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARE--RKINSSLQLPDRV 419
Query: 405 LQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVL 464
L F + H LM VR R +L++ Q ++ V RV TYDV+FLGT G +
Sbjct: 420 LNFLKDHFLMDGQVR---SRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLH 474
Query: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524
K + S P ++EELQ+F P+ + + R +LY S GV Q+ + C
Sbjct: 475 KAV------SVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSL 528
Query: 525 YGTACAECCLARDPYCAWDGASCTH---YRPSLGKRRFRRQDIRHGNPALQCLGQSQEEE 581
Y +C +C LARDPYCAW G+SC H Y+P L R + QDI + C S
Sbjct: 529 Y-RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPW-IQDIEGASAKDLCSASSVVSP 586
Query: 582 A---VGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTER 638
+ G V + L C S A WL R G P VL T
Sbjct: 587 SFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWL--RNG--APVNASASCHVLPTGD 642
Query: 639 GLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVI---VASQLD 680
LL + G + C +LE GF Q V V+ VA Q D
Sbjct: 643 LLL---VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTD 684
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 308 bits (790), Expect = 1e-83
Identities = 218/626 (34%), Positives = 318/626 (50%), Gaps = 49/626 (7%)
Query: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTEC 116
N A+ L E +D L++G +A++++ EV W ++ +C KG+ TEC
Sbjct: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108
Query: 117 ANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSR 176
N++RVLQP + T L CGT AFQP C + + G E G+GRCP +P+
Sbjct: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLNL------TSFKFLGKNEDGKGRCPFDPAH 162
Query: 177 PFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMA---ARIP 233
+ S +DGELY+G + +FLG E +I R+ P LR++ L++P FV A + P
Sbjct: 163 SYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTEYAIPWLNEPSFVFADVIRKSP 221
Query: 234 ENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLV 293
++ D ++D+VYFFF+E V V + R+ RVC D GG R L KW++FLKARL+
Sbjct: 222 DSPDGEDDRVYFFFTE-VSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Query: 294 CSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVF 353
CS P G F+ L DVF+L K YALF+ AVC Y+++ EVF
Sbjct: 281 CSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVF 337
Query: 354 -NGPFAHR---DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFAR 409
+G + + +W Y G VP PRPG C + S+ + PD+ LQF +
Sbjct: 338 SHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAAN--YTSSLNLPDKTLQFVK 395
Query: 410 AHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGT-YDVIFLGTDSGSVLKVIA 468
HPLM V P RP L+K + QIVVDR +A DGT YDV+F+ TD G++ K I+
Sbjct: 396 DHPLMDDSVTPIDNRPRLIKKDV--NYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAIS 453
Query: 469 LQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKR--QMLYVGSRLGVAQLRLHQCETYG 526
L E ++EE Q+F+ P+ + +S K+ + +Y GS GV Q L C +G
Sbjct: 454 L------EHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG 507
Query: 527 TACAECCLARDPYCAWD--GASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVG 584
T C +C LARDPYCAW A+C + R Q++ A C +S+
Sbjct: 508 T-CEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEM--SGDASVCPDKSK------ 558
Query: 585 LVAATMVYGTEHNSTF-LECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFR 643
+ + +H T L+C KS A V W Q G + ++ + L + LL
Sbjct: 559 --GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQ----NGVLKAESPKYGLMGRKNLLIF 612
Query: 644 RLSRFDAGTYTCTTLEHGFSQTVVRL 669
LS D+G Y C + E ++TV ++
Sbjct: 613 NLSEGDSGVYQCLSEERVKNKTVFQV 638
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 297 bits (761), Expect = 2e-80
Identities = 189/502 (37%), Positives = 269/502 (53%), Gaps = 32/502 (6%)
Query: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTEC 116
N A+ L E +D L++G +A++++ EV W ++ +C KG+ TEC
Sbjct: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108
Query: 117 ANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSR 176
N++RVLQP + T L CGT AFQP C + + G E G+GRCP +P+
Sbjct: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLNL------TSFKFLGKNEDGKGRCPFDPAH 162
Query: 177 PFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMA---ARIP 233
+ S +DGELY+G + +FLG E +I R+ P LR++ L++P FV A + P
Sbjct: 163 SYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTEYAIPWLNEPSFVFADVIRKSP 221
Query: 234 ENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLV 293
++ D ++D+VYFFF+E V V + R+ RVC D GG R L KW++FLKARL+
Sbjct: 222 DSPDGEDDRVYFFFTE-VSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Query: 294 CSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVF 353
CS P G F+ L DVF+L K YALF+ AVC Y+++ EVF
Sbjct: 281 CSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVF 337
Query: 354 -NGPFAHR---DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFAR 409
+G + + +W Y G VP PRPG C + S+ + PD+ LQF +
Sbjct: 338 SHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAAN--YTSSLNLPDKTLQFVK 395
Query: 410 AHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGT-YDVIFLGTDSGSVLKVIA 468
HPLM V P RP L+K + QIVVDR +A DGT YDV+F+ TD G++ K I+
Sbjct: 396 DHPLMDDSVTPIDNRPRLIKKDV--NYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAIS 453
Query: 469 LQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKR--QMLYVGSRLGVAQLRLHQCETYG 526
L E ++EE Q+F+ P+ + +S K+ + +Y GS GV Q L C +G
Sbjct: 454 L------EHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG 507
Query: 527 TACAECCLARDPYCAWDGASCT 548
T C +C LARDPYCAW + T
Sbjct: 508 T-CEDCVLARDPYCAWSPPTAT 528
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 276 bits (706), Expect = 5e-74
Identities = 228/675 (33%), Positives = 319/675 (47%), Gaps = 68/675 (10%)
Query: 15 LLLHGGSSGPSPGP---SVPRLRLSYRDLLSA-NRSAIFLGPQGSLNLQAMYLDEYRDRL 70
LLL SGP G SVPR L + S R A+ + N + +D L
Sbjct: 22 LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAV----PHTYNYSVLLVDPASHTL 77
Query: 71 FLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTH 130
++G D +++L L + PR + W R+ C +KG+ EC NFV++L N +H
Sbjct: 78 YVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKE-DECHNFVQILAIANASH 136
Query: 131 LLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTG 190
LL CGT AF P C +I V R + V LE SGRG+CP EP++ A+ G LY
Sbjct: 137 LLTCGTFAFDPKCGVIDVS-RFQQVERLE-----SGRGKCPFEPAQRSAAVMAGGVLYAA 190
Query: 191 LTADFLGREAMIFRS-GGPRPALRSDSDQSLLHDPRFVMAARIP--ENSDQD-NDKVYFF 246
++LG E +I R+ G +R+D+ S L+ P FV A + E D+D +D++YFF
Sbjct: 191 TVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFF 250
Query: 247 FSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHF 306
F+ET + D + V RV RVC D GG++ L +W+TFLKA L+C P G A +
Sbjct: 251 FTETSRAFDS-YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASS-- 307
Query: 307 DQLEDVFLLWPKAGKSLEV-YALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQH 365
L+DV +L P+ G + Y +FS+ AVC + DI V NGPF +
Sbjct: 308 -VLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCN 366
Query: 366 QWGP-YGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGR 424
+ P VP PRPG C + R FGS+ PD VL F R HPLM PV P G
Sbjct: 367 RGLPVVDNDVPQPRPGECITNNMKL--RHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGH 424
Query: 425 PVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLE 483
P+LV T A ++V RV + G YDV++LGT+ G + + + + A S VLE
Sbjct: 425 PLLVTTDTAYL--RVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLS------VLE 476
Query: 484 ELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWD 543
+L +F P P+ M++ L VGSR V Q+ C +C+EC LA+DP CAW
Sbjct: 477 DLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILAQDPVCAWS 533
Query: 544 GA--SCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLV----AATMVYGTEHN 597
C + G+ R QDI + + C + E V V AA +V +
Sbjct: 534 FRLDECVAH---AGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPS 590
Query: 598 STFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTT 657
S + C+ P +R G E V+ T + G Y C
Sbjct: 591 SAWASCVWHQPSGVTALTPRRDGLE----------VVVTPGAM----------GAYACEC 630
Query: 658 LEHGFSQTVVRLALV 672
E G + V +LV
Sbjct: 631 QEGGAAHVVAAYSLV 645
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 263 bits (671), Expect = 6e-70
Identities = 199/659 (30%), Positives = 314/659 (47%), Gaps = 65/659 (9%)
Query: 19 GGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDAL 78
GG GP +PR+R D R+ F +G + + L + L++G +A+
Sbjct: 33 GGGQGP-----MPRVRYYAGD---ERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAI 84
Query: 79 YSLRL-DQAWPDPREVL-WPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGT 136
+L + D P + ++ WP ++ EC K + T+C NF+RVL +N THL CGT
Sbjct: 85 LALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGT 144
Query: 137 GAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFL 196
AF P C I + + ++L + V G+G+ P +P+ + +DG LY+G +FL
Sbjct: 145 FAFSPACTFIEL--QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFL 202
Query: 197 GREAMIFRSGGPRPALRSDSDQSLLH-DPRFVMAARIPENSDQDNDKVYFFFSETVPSPD 255
G E ++ R+ G +P L++D+ LH D FV A IP VYFFF ET D
Sbjct: 203 GSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPSTQ-----VVYFFFEETASEFD 255
Query: 256 GGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLL 315
+ SRV RVC ND GG+++L KW+TFLKA+L+C+ PG + F+ + LL
Sbjct: 256 F-FERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHAVLL 310
Query: 316 WPKAGKSLEVYALFSTVSAV--FQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGK 373
+ + +YA+F++ V + AVC + + DI VF G + + +W Y G
Sbjct: 311 PADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGP 370
Query: 374 VPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLA 433
PRPG C S D+ L F + H LM V G P+LVK+ +
Sbjct: 371 ETNPRPGSC-------------SVGPSSDKALTFMKDHFLMDEQV---VGTPLLVKSGV- 413
Query: 434 QQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPT 492
+ ++ V+ + DG ++ V++LGT +GS+ K + S + ++EE+Q+F P
Sbjct: 414 -EYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVV-----SGDSSAHLVEEIQLFPDPE 467
Query: 493 PITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRP 552
P+ ++++ + ++VG GV ++ C Y +C +C LARDP+CAWD S T
Sbjct: 468 PVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLL 526
Query: 553 SLGKRRFRRQDIRHGNPALQC----LGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSP 608
S +QD+ GNP C + +S ++ + V ++ L C S
Sbjct: 527 SAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKE-VLAVPNSILELPCPHLSA 585
Query: 609 QAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVV 667
A+ W GP V ++ G L + G Y C E+GFS V+
Sbjct: 586 LASYYW------SHGPAAVPEASSTVY--NGSLLLIVQDGVGGLYQCWATENGFSYPVI 636
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 258 bits (659), Expect = 1e-68
Identities = 186/560 (33%), Positives = 267/560 (47%), Gaps = 50/560 (8%)
Query: 53 QGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRK 108
Q L+ Q M + RD L++ G D +Y++ L++ +++ W + RE C K
Sbjct: 54 QHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMK 111
Query: 109 GRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCA---LITVGHRGEHVLHLEPGSVES 165
G+ EC NF++V P N + CGT AF P C L T+ + GE + S
Sbjct: 112 GKHK-DECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI---------S 161
Query: 166 GRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDP 224
G RCP + + + F DG+LY+ ADFL +A+I+RS G ALR+ D + +P
Sbjct: 162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Query: 225 RFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNK 283
F+ A + VYFFF E + SRV R+C ND GG QRVL
Sbjct: 222 HFLHAIEY-------GNYVYFFFRE-IAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKH 273
Query: 284 WSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCV 343
W++FLKARL CSVPG + +FD L+ + + G V +F+T G AVC
Sbjct: 274 WTSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPT-VVGVFTTQLNSIPGSAVCA 330
Query: 344 YHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPD 402
+ M DI +VF G F + P W KVP PRPG C A+ + ++ D+PD
Sbjct: 331 FSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEA---YKTSIDFPD 387
Query: 403 EVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGS 462
E L F ++HPLM V P P KT + +L I VD Y VIF+G+++G
Sbjct: 388 ETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGM 447
Query: 463 VLKVIALQAGGSAEPEEVVLEELQVF---------KVPTPITEMEISVKRQMLYVGSRLG 513
VLKV+A + S + V+LEE++ + + + +++ LYV
Sbjct: 448 VLKVLAKTSPFSLN-DSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSC 506
Query: 514 VAQLRLHQCETYGTACAECCLARDPYCAW-DGASCTHYRPSLGKRRFRRQDIRHGNPALQ 572
+ ++ L +CE YG+ C +RDPYC W SC P + + QD GN A
Sbjct: 507 IIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGY-EQDTEFGNTA-- 563
Query: 573 CLGQSQEEEAVGLVAATMVY 592
LG + E TMVY
Sbjct: 564 HLGDCHDMEVSSSSVTTMVY 583
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 254 bits (648), Expect = 3e-67
Identities = 188/585 (32%), Positives = 272/585 (46%), Gaps = 63/585 (10%)
Query: 53 QGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRK 108
Q L+ Q M + RD L++ G D +Y++ L++ +++ W + RE C K
Sbjct: 54 QHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMK 111
Query: 109 GRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCA---LITVGHRGEHVLHLEPGSVES 165
G+ EC NF++V P N + CGT AF P C L T+ + GE + S
Sbjct: 112 GKHK-DECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI---------S 161
Query: 166 GRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDP 224
G RCP + + + F DG+LY+ ADFL +A+I+RS G ALR+ D + +P
Sbjct: 162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Query: 225 RFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNK 283
F+ A + VYFFF E + SRV R+C ND GG QRVL
Sbjct: 222 HFLHAIEY-------GNYVYFFFRE-IAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKH 273
Query: 284 WSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCV 343
W++FLKARL CSVPG + +FD L+ + + G V +F+T G AVC
Sbjct: 274 WTSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPT-VVGVFTTQLNSIPGSAVCA 330
Query: 344 YHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPD 402
+ M DI +VF G F + P W KVP PRPG C A+ + ++ D+PD
Sbjct: 331 FSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEA---YKTSIDFPD 387
Query: 403 EVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGS 462
E L F ++HPLM V P P KT + +L I VD Y VIF+G+++G
Sbjct: 388 ETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGM 447
Query: 463 VLKVIALQAGGSAEPEEVVLEELQVF---------KVPTPITEMEISVKRQMLYVGSRLG 513
VLKV+A + S + V+LEE++ + + + +++ LYV
Sbjct: 448 VLKVLAKTSPFSLN-DSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSC 506
Query: 514 VAQLRLHQCETYGTACAECCLARDPYCAW-DGASCTHYRPSLGKRRFRRQDIRHGNPALQ 572
+ ++ L +CE YG+ C +RDPYC W SC P + + QD GN A
Sbjct: 507 IIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGY-EQDTEFGNTA-- 563
Query: 573 CLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQ 617
LG E ++G P + VRW +Q
Sbjct: 564 HLGDCHEILPTSTTPDYKIFG-------------GPTSGVRWEVQ 595
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 253 bits (646), Expect = 5e-67
Identities = 179/538 (33%), Positives = 259/538 (48%), Gaps = 48/538 (8%)
Query: 53 QGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRK 108
Q L+ Q M + RD L++ G D +Y++ L++ +++ W + RE C K
Sbjct: 54 QHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMK 111
Query: 109 GRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCA---LITVGHRGEHVLHLEPGSVES 165
G+ EC NF++V P N + CGT AF P C L T+ + GE + S
Sbjct: 112 GKHK-DECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI---------S 161
Query: 166 GRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDP 224
G RCP + + + F DG+LY+ ADFL +A+I+RS G ALR+ D + +P
Sbjct: 162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Query: 225 RFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNK 283
F+ A + VYFFF E + SRV R+C ND GG QRVL
Sbjct: 222 HFLHAIEY-------GNYVYFFFRE-IAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKH 273
Query: 284 WSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCV 343
W++FLKARL CSVPG + +FD L+ + + G V +F+T G AVC
Sbjct: 274 WTSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPT-VVGVFTTQLNSIPGSAVCA 330
Query: 344 YHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPD 402
+ M DI +VF G F + P W KVP PRPG C A+ + ++ D+PD
Sbjct: 331 FSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEA---YKTSIDFPD 387
Query: 403 EVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGS 462
E L F ++HPLM V P P KT + +L I VD Y VIF+G+++G
Sbjct: 388 ETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGM 447
Query: 463 VLKVIALQAGGSAEPEEVVLEELQVF---------KVPTPITEMEISVKRQMLYVGSRLG 513
VLKV+A + S + V+LEE++ + + + +++ LYV
Sbjct: 448 VLKVLAKTSPFSLN-DSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSC 506
Query: 514 VAQLRLHQCETYGTACAECCLARDPYCAW-DGASCTHYRPSLGKRRFRRQDIRHGNPA 570
+ ++ L +CE YG+ C +RDPYC W SC P + + QD GN A
Sbjct: 507 IIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGY-EQDTEFGNTA 563
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 253 bits (646), Expect = 5e-67
Identities = 179/538 (33%), Positives = 259/538 (48%), Gaps = 48/538 (8%)
Query: 53 QGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRK 108
Q L+ Q M + RD L++ G D +Y++ L++ +++ W + RE C K
Sbjct: 54 QHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMK 111
Query: 109 GRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCA---LITVGHRGEHVLHLEPGSVES 165
G+ EC NF++V P N + CGT AF P C L T+ + GE + S
Sbjct: 112 GKHK-DECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI---------S 161
Query: 166 GRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDP 224
G RCP + + + F DG+LY+ ADFL +A+I+RS G ALR+ D + +P
Sbjct: 162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Query: 225 RFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNK 283
F+ A + VYFFF E + SRV R+C ND GG QRVL
Sbjct: 222 HFLHAIEY-------GNYVYFFFRE-IAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKH 273
Query: 284 WSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCV 343
W++FLKARL CSVPG + +FD L+ + + G V +F+T G AVC
Sbjct: 274 WTSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPT-VVGVFTTQLNSIPGSAVCA 330
Query: 344 YHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPD 402
+ M DI +VF G F + P W KVP PRPG C A+ + ++ D+PD
Sbjct: 331 FSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEA---YKTSIDFPD 387
Query: 403 EVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGS 462
E L F ++HPLM V P P KT + +L I VD Y VIF+G+++G
Sbjct: 388 ETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGM 447
Query: 463 VLKVIALQAGGSAEPEEVVLEELQVF---------KVPTPITEMEISVKRQMLYVGSRLG 513
VLKV+A + S + V+LEE++ + + + +++ LYV
Sbjct: 448 VLKVLAKTSPFSLN-DSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSC 506
Query: 514 VAQLRLHQCETYGTACAECCLARDPYCAW-DGASCTHYRPSLGKRRFRRQDIRHGNPA 570
+ ++ L +CE YG+ C +RDPYC W SC P + + QD GN A
Sbjct: 507 IIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGY-EQDTEFGNTA 563
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 251 bits (641), Expect = 2e-66
Identities = 172/518 (33%), Positives = 250/518 (48%), Gaps = 43/518 (8%)
Query: 70 LFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRKGRDPLTECANFVRVLQP 125
L++ D +Y++ +D + + +++ W + + C KG+ EC NF++VL
Sbjct: 68 LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHK-DECHNFIKVLLK 126
Query: 126 HNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEP-GSVESGRGRCPHEPSRPFASTFID 184
N L CGT AF P+C R + LEP G SG RCP++ + F D
Sbjct: 127 KNDDALFVCGTNAFNPSC-------RNYKMDTLEPFGDEFSGMARCPYDAKHANVALFAD 179
Query: 185 GELYTGLTADFLGREAMIFRSGGPRPALRS-DSDQSLLHDPRFVMAARIPENSDQDNDKV 243
G+LY+ DFL +A+I+RS G P LR+ D L +P FV A D +
Sbjct: 180 GKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDY-------GDYI 232
Query: 244 YFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNKWSTFLKARLVCSVPGPGGA 302
YFFF E + V RV +VC ND GG QRVL +W++FLKARL CSVPG +
Sbjct: 233 YFFFRE-IAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGD--S 289
Query: 303 ETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDG 362
+F+ L+ V + G+ + V A FST G AVC Y M DI VF G F +
Sbjct: 290 HFYFNILQAVTDVIRINGRDV-VLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKS 348
Query: 363 PQHQWGPYGG-KVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPR 421
P W P +VP PRPG C + + + ++ ++PD+ L F + HPLM V
Sbjct: 349 PDSTWTPVPDERVPKPRPGCCAGSSSLER---YATSNEFPDDTLNFIKTHPLMDEAVPSI 405
Query: 422 HGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVV 481
RP ++T + +L +I VD + V+FLG++ G +LK +A + +
Sbjct: 406 FNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLF 465
Query: 482 LEELQVFK---------VPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAEC 532
LEE+ V+ I M++ LYV V ++ L +CE +G C
Sbjct: 466 LEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTC 525
Query: 533 CLARDPYCAW--DGASCTHYRPSLGKRRFRRQDIRHGN 568
+RDPYC W +G +C+H P+ R QDI GN
Sbjct: 526 IASRDPYCGWIKEGGACSHLSPN--SRLTFEQDIERGN 561
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 250 bits (638), Expect = 4e-66
Identities = 174/522 (33%), Positives = 253/522 (48%), Gaps = 47/522 (9%)
Query: 53 QGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRK 108
Q L+ Q M + RD L++ G D +Y++ L++ +++ W + RE C K
Sbjct: 54 QHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMK 111
Query: 109 GRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCA---LITVGHRGEHVLHLEPGSVES 165
G+ EC NF++V P N + CGT AF P C L T+ + GE + S
Sbjct: 112 GKHK-DECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI---------S 161
Query: 166 GRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDP 224
G RCP + + + F DG+LY+ ADFL +A+I+RS G ALR+ D + +P
Sbjct: 162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Query: 225 RFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNK 283
F+ A + VYFFF E + SRV R+C ND GG QRVL
Sbjct: 222 HFLHAIEY-------GNYVYFFFRE-IAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKH 273
Query: 284 WSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCV 343
W++FLKARL CSVPG + +FD L+ + + G V +F+T G AVC
Sbjct: 274 WTSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPT-VVGVFTTQLNSIPGSAVCA 330
Query: 344 YHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPD 402
+ M DI +VF G F + P W KVP PRPG C A+ + ++ D+PD
Sbjct: 331 FSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEA---YKTSIDFPD 387
Query: 403 EVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGS 462
E L F ++HPLM V P P KT + +L I VD Y VIF+G+++G
Sbjct: 388 ETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGM 447
Query: 463 VLKVIALQAGGSAEPEEVVLEELQVF---------KVPTPITEMEISVKRQMLYVGSRLG 513
VLKV+A + S + V+LEE++ + + + +++ LYV
Sbjct: 448 VLKVLAKTSPFSLN-DSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSC 506
Query: 514 VAQLRLHQCETYGTACAECCLARDPYCAW-DGASCTHYRPSL 554
+ ++ L +CE YG+ C +RDPYC W SC P +
Sbjct: 507 IIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGM 548
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 246 bits (628), Expect = 6e-65
Identities = 195/613 (31%), Positives = 285/613 (46%), Gaps = 66/613 (10%)
Query: 15 LLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGP--------QGSLNLQAMYLDEY 66
LLL GG+ G P P L ++ RD L N +F+G +G+ +L +
Sbjct: 17 LLLLGGAHGLFP-EEPPPLSVAPRDYL--NHYPVFVGSGPGRLTPAEGADDLNIQRVLRV 73
Query: 67 RDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRKGRDPLTECANFVRV 122
LF+G D LY + L+ R++ W P C KG+ EC NFV+V
Sbjct: 74 NRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQE-GECRNFVKV 132
Query: 123 LQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEP-GSVESGRGRCPHEPSRPFAST 181
L + + L CG+ AF P CA ++ L+P G SG RCP++P +
Sbjct: 133 LLLRDESTLFVCGSNAFNPVCANYSIDT-------LQPVGDNISGMARCPYDPKHANVAL 185
Query: 182 FIDGELYTGLTADFLGREAMIFRSGGPRPALRS-DSDQSLLHDPRFVMAARIPENSDQDN 240
F DG L+T DFL +A+I+RS G RP LR+ D +P FV A +
Sbjct: 186 FSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV-------EWG 238
Query: 241 DKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQ-RVLVNKWSTFLKARLVCSVPGP 299
VYFFF E + V VSRV RVC ND GG RVL +W++FLKARL CSVPG
Sbjct: 239 SHVYFFFRE-IAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGD 297
Query: 300 GGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAH 359
+ +F+ L+ V + G+ + V A+FST S G AVC + + + VF G F
Sbjct: 298 --SHFYFNVLQAVTGVVSLGGRPV-VLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFRE 354
Query: 360 RDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPV 418
+ P+ W P +VP PRPG C A PG + ++ PD++L F + HPLM V
Sbjct: 355 QKSPESIWTPVPEDQVPRPRPGCC-----AAPGMQYNASSALPDDILNFVKTHPLMDEAV 409
Query: 419 RPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPE 478
P +++T + QL ++ VD G V+FLG+++G+VLK + ++
Sbjct: 410 PSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTS 469
Query: 479 --EVVLEELQVFK-----------VPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETY 525
V LEE + ++ + +E+ L V ++ + +C+ Y
Sbjct: 470 GLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQY 529
Query: 526 GTACAECCLARDPYCAW--DGASCTHYRPSLGKRRFRRQDIRHGNPA--LQCLG---QSQ 578
C ++DPYC W DG SC P G R QD+ + + C G S
Sbjct: 530 SGCMKNCIGSQDPYCGWAPDG-SCIFLSP--GTRAAFEQDVSGASTSGLGDCTGLLRASL 586
Query: 579 EEEAVGLVAATMV 591
E+ GLV+ ++
Sbjct: 587 SEDRAGLVSVNLL 599
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 232 bits (592), Expect = 9e-61
Identities = 165/488 (33%), Positives = 241/488 (49%), Gaps = 49/488 (10%)
Query: 103 EECVRKGRDPLT-ECANFVRVLQPHNRTHLLACGTGAFQPTC---ALITVGHRGEHVLHL 158
E C +G+ LT EC N++RVL P + LLACGT +F P C + ++ GE +
Sbjct: 109 ENCAVRGK--LTDECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEEL--- 163
Query: 159 EPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-D 217
SG+ RCP + ++ + F +G LY+ ADF +A+++RS GP+P LRS D
Sbjct: 164 ------SGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYD 217
Query: 218 QSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQ 277
L +P FV A + D VYFFF E V D V SRV RVC D GG
Sbjct: 218 SKWLREPHFVQAL-------EHGDHVYFFFRE-VSVEDARLGRVQFSRVARVCKRDMGGS 269
Query: 278 -RVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVF 336
R L W++FLK RL CSV PG + +FD L+ + G+S ++ +F+T +
Sbjct: 270 PRALDRHWTSFLKLRLNCSV--PGDSTFYFDVLQALTGPVNLHGRS-ALFGVFTTQTNSI 326
Query: 337 QGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFG 395
G AVC +++ +I F G F + W P +VP PRPG C A F
Sbjct: 327 PGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGA---ALFS 383
Query: 396 STKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIF 455
S++D PD+VL F +AHPL+ V P +P+L T A L Q+ VD + V+F
Sbjct: 384 SSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRA-LLTQVAVDGMAGPHSNITVMF 442
Query: 456 LGTDSGSVLKVIALQAGGSAEPEEVVLEELQVF-----------KVPTPITEMEISVKRQ 504
LG++ G+VLKV+ G S PE ++LEE+ + + I +E+ +
Sbjct: 443 LGSNDGTVLKVLT-PGGRSGGPEPILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGH 501
Query: 505 MLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGA-SCTHYRPSLG---KRRFR 560
L+V + L L +C +G C ++DPYC W + C R S G +
Sbjct: 502 RLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGWHSSRGCVDIRGSGGTDVDQAGN 561
Query: 561 RQDIRHGN 568
++ + HG+
Sbjct: 562 QESMEHGD 569
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 221 bits (564), Expect = 2e-57
Identities = 156/446 (34%), Positives = 223/446 (50%), Gaps = 37/446 (8%)
Query: 53 QGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDP----REVLWPPQPGQREECVRK 108
Q L+ Q M + RD L++ G D +Y++ L++ +++ W + RE C K
Sbjct: 54 QHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMK 111
Query: 109 GRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCA---LITVGHRGEHVLHLEPGSVES 165
G+ EC NF++V P N + CGT AF P C L T+ + GE + S
Sbjct: 112 GKHK-DECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI---------S 161
Query: 166 GRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDP 224
G RCP + + + F DG+LY+ ADFL +A+I+RS G ALR+ D + +P
Sbjct: 162 GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Query: 225 RFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGG-QRVLVNK 283
F+ A + VYFFF E + SRV R+C ND GG QRVL
Sbjct: 222 HFLHAIEY-------GNYVYFFFRE-IAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKH 273
Query: 284 WSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCV 343
W++FLKARL CSVPG + +FD L+ + + G V +F+T G AVC
Sbjct: 274 WTSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPT-VVGVFTTQLNSIPGSAVCA 330
Query: 344 YHMADIWEVFNGPFAHRDGPQHQWGPYG-GKVPFPRPGVCPSKMTAQPGRPFGSTKDYPD 402
+ M DI +VF G F + P W KVP PRPG C A+ + ++ D+PD
Sbjct: 331 FSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEA---YKTSIDFPD 387
Query: 403 EVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGS 462
E L F ++HPLM V P P KT + +L I VD Y VIF+G+++G
Sbjct: 388 ETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGM 447
Query: 463 VLKVIALQAGGSAEPEEVVLEELQVF 488
VLKV+A + S + V+LEE++ +
Sbjct: 448 VLKVLAKTSPFSLN-DSVLLEEIEAY 472
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 208 bits (530), Expect = 1e-53
Identities = 159/495 (32%), Positives = 236/495 (47%), Gaps = 43/495 (8%)
Query: 54 GSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPL 113
G+ + + LD ++L +G + L+ L L + W R C KG+
Sbjct: 122 GARDFSQLALDPSGNQLIVGARNYLFRLSLANV-SLLQATEWASSEDTRRSCQSKGKTE- 179
Query: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHE 173
EC N+VRVL R + CGT AF P C VG+ + + +G RCP++
Sbjct: 180 EECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPYD 232
Query: 174 PSRPFASTFID-GELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAAR 231
P + GELY DF GR+ I+RS G P LR+ S L++P FV A
Sbjct: 233 PRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYD 292
Query: 232 IPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKAR 291
I + YFF E D G SRV RVC ND GG+ +L + W+TF+KAR
Sbjct: 293 IGLFA-------YFFLRENAVEHDCG--RTVYSRVARVCKNDVGGRFLLEDTWTTFMKAR 343
Query: 292 LVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWE 351
L CS PG ++++L+ F L P+ +Y +F+T AVC ++++ I +
Sbjct: 344 LNCS--RPGEVPFYYNELQSAFHL-PEQDL---IYGVFTTNVNSIAASAVCAFNLSAISQ 397
Query: 352 VFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAH 411
FNGPF +++ P+ W P +P + G P G ++ + LQ A+
Sbjct: 398 AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPET---------GPNENLTERSLQDAQRL 448
Query: 412 PLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQA 471
LM V+P P + T + + +VVD V+A+D Y V+++GT+SG++LK ++
Sbjct: 449 FLMSEAVQPVTPEPCV--TQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALST-- 504
Query: 472 GGSAEPEEVVLEELQVFKV--PTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTAC 529
S LEEL V P+ + I + L+VG R GV ++ L +C Y +
Sbjct: 505 -ASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQG 563
Query: 530 AECCLARDPYCAWDG 544
A C ARDPYC WDG
Sbjct: 564 A-CLGARDPYCGWDG 577
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 191 bits (484), Expect = 3e-48
Identities = 162/565 (28%), Positives = 260/565 (46%), Gaps = 55/565 (9%)
Query: 8 ICWLLGGL----LLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYL 63
I WL L L H + G + +SY+++ R + +++ +
Sbjct: 7 IAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLRE---FRAKNAVDFSQLTF 63
Query: 64 DEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVL 123
D + L +G + L+ L+L+ + V W ++ C KG+ EC N++RVL
Sbjct: 64 DPGQKELVVGARNYLFRLQLEDL-SLIQAVEWECDEATKKACYSKGKSK-EECQNYIRVL 121
Query: 124 QPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFI 183
L CGT AF P C ++ + E +H + SG RCP+ P +
Sbjct: 122 LVGG-DRLFTCGTNAFTPVCTNRSLSNLTE--IHDQI----SGMARCPYSPQHNSTALLT 174
Query: 184 -DGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAARIPENSDQDND 241
GELY DF GR+ I+RS G P LR+ S L++P FV + I +
Sbjct: 175 AGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDI-------GN 227
Query: 242 KVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGG 301
YFFF E D G SR RVC ND GG+ +L + W+TF+KARL CS PG
Sbjct: 228 FTYFFFRENAVEHDCGKT--VFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCS--RPGE 283
Query: 302 AETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRD 361
++++L+ F L P+ +Y +F+T AVCV++++ I + F+GPF +++
Sbjct: 284 VPFYYNELQSTFFL-PELDL---IYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQE 339
Query: 362 GPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPR 421
+ W PY P + G G + + LQ A+ LM V+P
Sbjct: 340 NSRSAWLPYPNPNPHFQCGTVDQ----------GLYVNLTERNLQDAQKFILMHEVVQPV 389
Query: 422 HGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKV-IALQAGGSAEPEEV 480
P ++ + + + VD V+ + +I+L TD G++ KV + L S+
Sbjct: 390 TTVPSFMEDN--SRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSS----C 443
Query: 481 VLEELQVF--KVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDP 538
+LEE+++F + PI ++I + +L+VG R V ++ L +C+ Y T + C A+DP
Sbjct: 444 LLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTR-STCIGAQDP 502
Query: 539 YCAWDGA--SCTHYRPSLGKRRFRR 561
YC WD CT SL ++ +
Sbjct: 503 YCGWDVVMKKCTSLEESLSMTQWEQ 527
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 183 bits (465), Expect = 5e-46
Identities = 159/546 (29%), Positives = 241/546 (44%), Gaps = 74/546 (13%)
Query: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALI---TVGHRGEHVLHLEPGSVESGRGRC 170
T+C N++ +L+ + LLACGT A P+C + TV GE RG
Sbjct: 110 TDCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVPLGEM------------RGYA 156
Query: 171 PHEPSRPFASTFIDGELYTGLTA-DFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMA 229
P P F E+Y+ + ++ G+ R G SD+ ++ +P+F+ A
Sbjct: 157 PFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDT---VMQNPQFIKA 213
Query: 230 ARIPENSDQDNDKVYFFFSETVP--SPDGGSNHVTVSRVGRVCVNDAGGQRVL-VNKWST 286
+ ++ D DK+Y+FF E P +P+ N VSRV ++C D GG+ L V+KW+T
Sbjct: 214 TIVHQDQAYD-DKIYYFFREDNPDKNPEAPLN---VSRVAQLCRGDQGGESSLSVSKWNT 269
Query: 287 FLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAG--KSLEVYALFSTVSAVFQGFAVCVY 344
FLKA LVCS +F++L+DVFLL +G + VY +FS + AVCVY
Sbjct: 270 FLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP---WNYSAVCVY 323
Query: 345 HMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEV 404
+ DI +VF Y +P PRPG C + P E
Sbjct: 324 SLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-----------LPDQQPIPTET 363
Query: 405 LQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSV 463
Q A HP + V P G H ++ V R++A G T+ V++L TD G++
Sbjct: 364 FQVADRHPEVAQRVEPM-GPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTI 422
Query: 464 LKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCE 523
KV+ + G + E+Q F+ I M + +R+ LYV S+ V+Q+ L CE
Sbjct: 423 HKVV--EPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCE 480
Query: 524 TYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAV 583
YG C C ++RDPYC WD C S R Q I P +C ++ +
Sbjct: 481 VYGGGCHGCLMSRDPYCGWDQGRCISIYSS---ERSVLQSINPAEPHKECPNPKPDKAPL 537
Query: 584 GLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQ-------RPGDEGPDQVKTDERVLHT 636
V+ ++ +L C +S A W + PG + P+ + E +
Sbjct: 538 QKVSL-----APNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQ 592
Query: 637 ERGLLF 642
+ G F
Sbjct: 593 QYGHYF 598
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 181 bits (460), Expect = 2e-45
Identities = 158/545 (28%), Positives = 240/545 (44%), Gaps = 74/545 (13%)
Query: 115 ECANFVRVLQPHNRTHLLACGTGAFQPTCALI---TVGHRGEHVLHLEPGSVESGRGRCP 171
+C N++ +L+ + LLACGT A P+C + TV GE RG P
Sbjct: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVPLGEM------------RGYAP 171
Query: 172 HEPSRPFASTFIDGELYTGLTA-DFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAA 230
P F E+Y+ + ++ G+ R G SD+ ++ +P+F+ A
Sbjct: 172 FSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDT---VMQNPQFIKAT 228
Query: 231 RIPENSDQDNDKVYFFFSETVP--SPDGGSNHVTVSRVGRVCVNDAGGQRVL-VNKWSTF 287
+ ++ D DK+Y+FF E P +P+ N VSRV ++C D GG+ L V+KW+TF
Sbjct: 229 IVHQDQAYD-DKIYYFFREDNPDKNPEAPLN---VSRVAQLCRGDQGGESSLSVSKWNTF 284
Query: 288 LKARLVCSVPGPGGAETHFDQLEDVFLLWPKAG--KSLEVYALFSTVSAVFQGFAVCVYH 345
LKA LVCS +F++L+DVFLL +G + VY +FS + AVCVY
Sbjct: 285 LKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP---WNYSAVCVYS 338
Query: 346 MADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVL 405
+ DI +VF Y +P PRPG C + P E
Sbjct: 339 LGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-----------LPDQQPIPTETF 378
Query: 406 QFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVL 464
Q A HP + V P G H ++ V R++A G T+ V++L TD G++
Sbjct: 379 QVADRHPEVAQRVEPM-GPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIH 437
Query: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524
KV+ + G + E+Q F+ I M + +R+ LYV S+ V+Q+ L CE
Sbjct: 438 KVV--EPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEV 495
Query: 525 YGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVG 584
YG C C ++RDPYC WD C S R Q I P +C ++ +
Sbjct: 496 YGGGCHGCLMSRDPYCGWDQGRCISIYSS---ERSVLQSINPAEPHKECPNPKPDKAPLQ 552
Query: 585 LVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQ-------RPGDEGPDQVKTDERVLHTE 637
V+ ++ +L C +S A W + PG + P+ + E + +
Sbjct: 553 KVSL-----APNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQ 607
Query: 638 RGLLF 642
G F
Sbjct: 608 YGHYF 612
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 169 bits (427), Expect = 1e-41
Identities = 142/490 (28%), Positives = 216/490 (44%), Gaps = 58/490 (11%)
Query: 167 RGRCPHEPSRPFASTFIDGELYTGLTA-DFLGREAMIFRSGGPRPALRSDSDQSLLHDPR 225
RG P P F E+Y+ + ++ G+ R G SD+ ++ +P+
Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDT---VMQNPQ 58
Query: 226 FVMAARIPENSDQDNDKVYFFFSETVP--SPDGGSNHVTVSRVGRVCVNDAGGQRVL-VN 282
F+ A + ++ D DK+Y+FF E P +P+ N VSRV ++C D GG+ L V+
Sbjct: 59 FIKATIVHQDQAYD-DKIYYFFREDNPDKNPEAPLN---VSRVAQLCRGDQGGESSLSVS 114
Query: 283 KWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAG--KSLEVYALFSTVSAVFQGFA 340
KW+TFLKA LVCS +F++L+DVFLL +G + VY +FS + A
Sbjct: 115 KWNTFLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP---WNYSA 168
Query: 341 VCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDY 400
VCVY + DI +VF Y +P PRPG C +
Sbjct: 169 VCVYSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-----------LPDQQPI 208
Query: 401 PDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTD 459
P E Q A HP + V P G H ++ V R++A G T+ V++L TD
Sbjct: 209 PTETFQVADRHPEVAQRVEPM-GPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTD 267
Query: 460 SGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRL 519
G++ KV+ + G + E+Q F+ I M + +R+ LYV S+ V+Q+ L
Sbjct: 268 RGTIHKVV--EPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPL 325
Query: 520 HQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQE 579
CE YG C C ++RDPYC WD C S R Q I P +C +
Sbjct: 326 DLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSS---ERSVLQSINPAEPHKECPNPKPD 382
Query: 580 EEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQ-------RPGDEGPDQVKTDER 632
+ + V+ ++ +L C +S A W + PG + P+ + E
Sbjct: 383 KAPLQKVSL-----APNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIEN 437
Query: 633 VLHTERGLLF 642
+ + G F
Sbjct: 438 LTAQQYGHYF 447
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,726,768
Number of Sequences: 37866
Number of extensions: 1911662
Number of successful extensions: 6158
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 5803
Number of HSP's gapped (non-prelim): 171
length of query: 782
length of database: 18,247,518
effective HSP length: 110
effective length of query: 672
effective length of database: 14,082,258
effective search space: 9463277376
effective search space used: 9463277376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.