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Search of human proteins with 9506747
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9506747 G protein-coupled receptor 27 [Homo sapiens]
(375 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9506747 G protein-coupled receptor 27 [Homo sapiens] 762 0.0
gi|9507143 G protein-coupled receptor 173 [Homo sapiens] 399 e-111
gi|226342980 G protein-coupled receptor 85 [Homo sapiens] 386 e-107
gi|226342978 G protein-coupled receptor 85 [Homo sapiens] 386 e-107
gi|226342976 G protein-coupled receptor 85 [Homo sapiens] 386 e-107
gi|153266936 G protein-coupled receptor 85 [Homo sapiens] 386 e-107
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 80 2e-15
gi|32483397 dopamine receptor D4 [Homo sapiens] 79 5e-15
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 77 2e-14
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 77 3e-14
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 76 4e-14
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 75 1e-13
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 72 1e-12
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 71 2e-12
gi|28875799 cholecystokinin B receptor [Homo sapiens] 71 2e-12
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 70 2e-12
gi|57165371 G protein-coupled receptor 61 [Homo sapiens] 69 9e-12
gi|222080095 orexin receptor 1 [Homo sapiens] 68 2e-11
gi|194018562 histamine receptor H3 [Homo sapiens] 67 3e-11
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 66 4e-11
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 66 4e-11
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 66 4e-11
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 65 8e-11
gi|4557865 somatostatin receptor 5 [Homo sapiens] 64 3e-10
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 64 3e-10
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 63 4e-10
gi|32261309 G protein-coupled receptor 135 [Homo sapiens] 63 5e-10
gi|4758474 G protein-coupled receptor 10 [Homo sapiens] 63 5e-10
gi|5174595 melatonin receptor 1B [Homo sapiens] 62 1e-09
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 61 1e-09
>gi|9506747 G protein-coupled receptor 27 [Homo sapiens]
Length = 375
Score = 762 bits (1967), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 1 MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDL 60
MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDL
Sbjct: 1 MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDL 60
Query: 61 CLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTR 120
CLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTR
Sbjct: 61 CLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTR 120
Query: 121 YLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGA 180
YLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGA
Sbjct: 121 YLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGA 180
Query: 181 PGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAA 240
PGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAA
Sbjct: 181 PGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAA 240
Query: 241 NWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPY 300
NWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPY
Sbjct: 241 NWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPY 300
Query: 301 VVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR 360
VVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR
Sbjct: 301 VVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR 360
Query: 361 TTQATHPCDLKGIGL 375
TTQATHPCDLKGIGL
Sbjct: 361 TTQATHPCDLKGIGL 375
>gi|9507143 G protein-coupled receptor 173 [Homo sapiens]
Length = 373
Score = 399 bits (1026), Expect = e-111
Identities = 197/362 (54%), Positives = 259/362 (71%), Gaps = 12/362 (3%)
Query: 1 MANAS----EPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYL 56
MAN + E G+ +A+ +KL L L++CVSLAGN + +LL+++ER+LH+APYY
Sbjct: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
Query: 57 LLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGV 116
LLDLCLADG+R+ C P V+ + R ++ + AL CK++AF+A LFCFHAAF+L +
Sbjct: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFS---ALSCKIVAFMAVLFCFHAAFMLFCI 117
Query: 117 GVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCAL 173
VTRY+AIAHHRFYA+R+ W CAA+ +C AW L++A AFPPV D G E+ C
Sbjct: 118 SVTRYMAIAHHRFYAKRMTLWTCAAV-ICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF 176
Query: 174 EQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPG 233
E R A LGF+L+LAV++ ATH VY +LL F + RKM+P ++VPA+S +WTFHGPG
Sbjct: 177 EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPG 236
Query: 234 ATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLF 293
ATGQAAANW AGFGRGP PP L+GIR G +RRLL ++E K EK+L +MFYA+TLLF
Sbjct: 237 ATGQAAANWIAGFGRGPMPPTLLGIRQNGHA-ASRRLLGMDEVKGEKQLGRMFYAITLLF 295
Query: 294 LLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQF 353
LLLW PY+VA Y RV V+ AVP YL +VW++FAQA +NP+VCFL N++L+ C R
Sbjct: 296 LLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA 355
Query: 354 PC 355
PC
Sbjct: 356 PC 357
>gi|226342980 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 386 bits (992), Expect = e-107
Identities = 190/344 (55%), Positives = 241/344 (70%), Gaps = 7/344 (2%)
Query: 20 LKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAA 79
LKL +L ++ VS+ GN+L ++L+V++++LHRAPYY LLDLC +D LR+ C P V +
Sbjct: 22 LKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSV 81
Query: 80 RRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPC 139
+ + G L CK++AFL L CFH AF+L + VTRYLAIAHHRFY +RL W C
Sbjct: 82 KNGSTWTY---GTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTC 138
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCALEQRPDGAPGALGFLLLLAVVVGA 196
A+ +C W L++A AFPPVLD G E+ C + R A +LGF+LLLA+++ A
Sbjct: 139 LAV-ICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLA 197
Query: 197 THLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALV 256
T LVYL+L+FF+HDRRKM+P + V AVS +WTFHGPGA+GQAAANW AGFGRGPTPP L+
Sbjct: 198 TQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLL 257
Query: 257 GIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVP 316
GIR G RRLLVL+EFK EKR+ +MFY +T LFL LWGPY+VA Y RV R VP
Sbjct: 258 GIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVP 317
Query: 317 QAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR 360
+LTA+VW++FAQAGINP VC NRELR CF C+ R
Sbjct: 318 GGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSR 361
>gi|226342978 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 386 bits (992), Expect = e-107
Identities = 190/344 (55%), Positives = 241/344 (70%), Gaps = 7/344 (2%)
Query: 20 LKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAA 79
LKL +L ++ VS+ GN+L ++L+V++++LHRAPYY LLDLC +D LR+ C P V +
Sbjct: 22 LKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSV 81
Query: 80 RRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPC 139
+ + G L CK++AFL L CFH AF+L + VTRYLAIAHHRFY +RL W C
Sbjct: 82 KNGSTWTY---GTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTC 138
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCALEQRPDGAPGALGFLLLLAVVVGA 196
A+ +C W L++A AFPPVLD G E+ C + R A +LGF+LLLA+++ A
Sbjct: 139 LAV-ICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLA 197
Query: 197 THLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALV 256
T LVYL+L+FF+HDRRKM+P + V AVS +WTFHGPGA+GQAAANW AGFGRGPTPP L+
Sbjct: 198 TQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLL 257
Query: 257 GIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVP 316
GIR G RRLLVL+EFK EKR+ +MFY +T LFL LWGPY+VA Y RV R VP
Sbjct: 258 GIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVP 317
Query: 317 QAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR 360
+LTA+VW++FAQAGINP VC NRELR CF C+ R
Sbjct: 318 GGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSR 361
>gi|226342976 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 386 bits (992), Expect = e-107
Identities = 190/344 (55%), Positives = 241/344 (70%), Gaps = 7/344 (2%)
Query: 20 LKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAA 79
LKL +L ++ VS+ GN+L ++L+V++++LHRAPYY LLDLC +D LR+ C P V +
Sbjct: 22 LKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSV 81
Query: 80 RRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPC 139
+ + G L CK++AFL L CFH AF+L + VTRYLAIAHHRFY +RL W C
Sbjct: 82 KNGSTWTY---GTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTC 138
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCALEQRPDGAPGALGFLLLLAVVVGA 196
A+ +C W L++A AFPPVLD G E+ C + R A +LGF+LLLA+++ A
Sbjct: 139 LAV-ICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLA 197
Query: 197 THLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALV 256
T LVYL+L+FF+HDRRKM+P + V AVS +WTFHGPGA+GQAAANW AGFGRGPTPP L+
Sbjct: 198 TQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLL 257
Query: 257 GIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVP 316
GIR G RRLLVL+EFK EKR+ +MFY +T LFL LWGPY+VA Y RV R VP
Sbjct: 258 GIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVP 317
Query: 317 QAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR 360
+LTA+VW++FAQAGINP VC NRELR CF C+ R
Sbjct: 318 GGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSR 361
>gi|153266936 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 386 bits (992), Expect = e-107
Identities = 190/344 (55%), Positives = 241/344 (70%), Gaps = 7/344 (2%)
Query: 20 LKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAA 79
LKL +L ++ VS+ GN+L ++L+V++++LHRAPYY LLDLC +D LR+ C P V +
Sbjct: 22 LKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSV 81
Query: 80 RRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPC 139
+ + G L CK++AFL L CFH AF+L + VTRYLAIAHHRFY +RL W C
Sbjct: 82 KNGSTWTY---GTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTC 138
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCALEQRPDGAPGALGFLLLLAVVVGA 196
A+ +C W L++A AFPPVLD G E+ C + R A +LGF+LLLA+++ A
Sbjct: 139 LAV-ICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLA 197
Query: 197 THLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALV 256
T LVYL+L+FF+HDRRKM+P + V AVS +WTFHGPGA+GQAAANW AGFGRGPTPP L+
Sbjct: 198 TQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLL 257
Query: 257 GIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVP 316
GIR G RRLLVL+EFK EKR+ +MFY +T LFL LWGPY+VA Y RV R VP
Sbjct: 258 GIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVP 317
Query: 317 QAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPR 360
+LTA+VW++FAQAGINP VC NRELR CF C+ R
Sbjct: 318 GGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSR 361
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 80.5 bits (197), Expect = 2e-15
Identities = 93/365 (25%), Positives = 140/365 (38%), Gaps = 50/365 (13%)
Query: 20 LKLATLSLLLCV--SLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVML 77
L A L +L+ + ++ GN L L + E+ L A Y L+ L +AD L L +P +L
Sbjct: 54 LHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALL 113
Query: 78 AARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGW 137
A P + C FL LF + L + V RY+AI A +
Sbjct: 114 TIMFEAM---WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAI-KKPIQANQYNSR 169
Query: 138 PCAAMLVCAAWALALAAAFPPVLDGGGDDEDAP----CALEQRPDGAPGALGFLLLLAVV 193
A + + W +++ A P + G D D P C L + G F+L ++
Sbjct: 170 ATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFG-----DFMLFGSLA 224
Query: 194 VGATHLVYLRLLFFIHDRRKMRPARLV---PAVSHDWTFHGPGATGQAAANWTAGFGRGP 250
T L + + +F+ + A LV P W + F R
Sbjct: 225 AFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTW------------LTVSTVFQRDE 272
Query: 251 TP-------PALVGIR--PAGPGRGARRLL---------VLEEFKTEKRLCKMFYAVTLL 292
TP L G R A P G L+ ++ E+R K+ V L
Sbjct: 273 TPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFL 332
Query: 293 FLLLWGPYVVASYLRVLVRP--GAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFR 350
FLL+W P+ + + VL Q L VW+ + +G+NP+V LFN+ RD F
Sbjct: 333 FLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFG 392
Query: 351 AQFPC 355
C
Sbjct: 393 RYITC 397
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 79.3 bits (194), Expect = 5e-15
Identities = 105/404 (25%), Positives = 144/404 (35%), Gaps = 61/404 (15%)
Query: 8 GGSGGGEAAALGLKLATLS---LLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLAD 64
G S G A G A L LL+ LAGN L + + ER+L ++ L AD
Sbjct: 21 GASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAAD 80
Query: 65 GLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAI 124
L AL LP + + + A +P C L + + C + F L + V R++A+
Sbjct: 81 LLLALLVLPLFVYSEVQGGAWLLSP---RLCDALMAMDVMLCTASIFNLCAISVDRFVAV 137
Query: 125 AHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGD---DEDAPCALEQRPDGA- 180
A Y R G +L+ A W L+ A A PVL G D + A C LE R
Sbjct: 138 AVPLRY-NRQGGSRRQLLLIGATWLLSAAVA-APVLCGLNDVRGRDPAVCRLEDRDYVVY 195
Query: 181 --------PGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGP 232
P L LL A G R +H R RP+ P P
Sbjct: 196 SSVCSFFLPCPLMLLLYWATFRGLQRWEVARRA-KLHGRAPRRPSGPGPPSPTPPAPRLP 254
Query: 233 -GATGQAAANWTAGFGRGPTPPALVGIRP-----------AGPGRG-------------- 266
G A G RGP P P A P G
Sbjct: 255 QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPD 314
Query: 267 --------------ARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRP 312
RR + E++ ++ V FLL W P+ V + L
Sbjct: 315 AVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPA 374
Query: 313 GAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCC 356
+VP ++A WL + + +NPV+ +FN E R+ FR C
Sbjct: 375 CSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRAC 418
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 77.4 bits (189), Expect = 2e-14
Identities = 76/341 (22%), Positives = 140/341 (41%), Gaps = 36/341 (10%)
Query: 26 SLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAA 85
++++ +++AGN+L + + E+ L A Y L+ L +AD L +P ML
Sbjct: 82 AVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRW 141
Query: 86 AGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIA---HHRFYAERLAGWPCAAM 142
P + C + +L LF + L + + RY+AI HH + R A +
Sbjct: 142 ---PLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTK----AFL 194
Query: 143 LVCAAWALALAAAFPPVLDGGGDD----EDAPCALEQRPDGAPGALGFLLLLAVVVGATH 198
+ A W +++ + P + G DD ++ C L F+L+ + V
Sbjct: 195 KIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD--------NFVLIGSFVSFFIP 246
Query: 199 LVYLRLLFFIHDRRKMRPARL-VPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVG 257
L + + +F+ + + A L V + Q++ + F R
Sbjct: 247 LTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH------ 300
Query: 258 IRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGA--- 314
R G G R ++ E++ CK+ V LF+++W P+ + + + V+ +
Sbjct: 301 -REPGSYTGRR---TMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNED 356
Query: 315 VPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
V A L VW+ + + +NP+V LFN+ R F C
Sbjct: 357 VIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQC 397
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 76.6 bits (187), Expect = 3e-14
Identities = 93/346 (26%), Positives = 139/346 (40%), Gaps = 33/346 (9%)
Query: 14 EAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLP 73
EAA G A L+L + ++ GN+L + I L + L AD + L +P
Sbjct: 36 EAALAG---ALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP 92
Query: 74 AVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAER 133
A A P GA GC+L + L + L + V RYLA+ + Y
Sbjct: 93 P----AATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGA- 147
Query: 134 LAGWPCAAMLVCAAWALALAAAFPPVLDG----GGDDEDAPCALEQRPDGAPGALGFLLL 189
L CA V W ++ A +F P++ G D E C R + ++LL
Sbjct: 148 LVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLL 207
Query: 190 LAVVVGATHLVYLRLLF-----FIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTA 244
+ V + +L L +LF F+ R++R R + P A ++ A
Sbjct: 208 SSSV--SFYLPLLVMLFVYARVFVVATRQLRLLR--GELGRFPPEESPPAPSRSLAPAPV 263
Query: 245 GFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVAS 304
G P G RPA RLL L E + LC + + F L W P+ +A+
Sbjct: 264 GTCAPPEGVPACGRRPA-------RLLPLREHRA---LCTLGLIMGT-FTLCWLPFFLAN 312
Query: 305 YLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFR 350
LR L P VP A WL +A + NP++ + + + R FR
Sbjct: 313 VLRALGGPSLVPGPAFLALNWLGYANSAFNPLI-YCRSPDFRSAFR 357
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 76.3 bits (186), Expect = 4e-14
Identities = 81/349 (23%), Positives = 136/349 (38%), Gaps = 30/349 (8%)
Query: 22 LATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARR 81
L+ +L+L + + GN L + +++ER+L YL++ L +AD L A +P V+
Sbjct: 34 LSYCALILAI-VFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
Query: 82 AAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPC-- 139
+ + C + L + C + L + + RY A+ Y C
Sbjct: 93 GGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRR 149
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVV-----V 194
A+++ A W LA A + P + + C++ PD F++ +VV
Sbjct: 150 VALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISN-PD-------FVIYSSVVSFYLPF 201
Query: 195 GATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPA 254
G T LVY R+ + RR+ R ++ + PG Q + A
Sbjct: 202 GVTVLVYARIYVVLKQRRRKR---ILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSI 258
Query: 255 LVGIRPAGPGRGARRLLVLEEFKT--------EKRLCKMFYAVTLLFLLLWGPYVVASYL 306
GPG R + E KT EK+ +M V F++ W P+ + L
Sbjct: 259 CQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVL 318
Query: 307 RVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
+ V +A+ WL + + +NPV+ FN E R F C
Sbjct: 319 NTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 74.7 bits (182), Expect = 1e-13
Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 37/348 (10%)
Query: 24 TLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAA 83
++ +++ +++ GN+L + + E+ LH A Y L+ L +AD L L +P +LA
Sbjct: 59 SIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDY 118
Query: 84 AAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLA----IAHHRFYAERLAGWPC 139
P C + L LF + L + + RY+A I H RF +
Sbjct: 119 V---WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTK----- 170
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDDE-----DAPCALEQRPDGAPGA-LGFLLLLAVV 193
A M + WA+++ + P + G D+E + C L G+ + F + L ++
Sbjct: 171 AIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIM 230
Query: 194 VGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGAT---GQAAANWTAGFGRGP 250
V + Y ++ + + M + H T PG + + TA
Sbjct: 231 V----ITYCLTIYVLRRQALM--------LLHGHTEEPPGLSLDFLKCCKRNTAEEENSA 278
Query: 251 TPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLV 310
P R + R ++ E++ K+ V +FL++W P+ + + L VL
Sbjct: 279 NPNQDQNAR-RRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLC 337
Query: 311 RPGA---VPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
+ + L VW+ + +GINP+V LFN+ R F C
Sbjct: 338 EKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 71.6 bits (174), Expect = 1e-12
Identities = 86/379 (22%), Positives = 144/379 (37%), Gaps = 57/379 (15%)
Query: 22 LATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARR 81
L+ +L+L + + GN L + +++ER+L YL++ L +AD L A +P V+
Sbjct: 34 LSYCALILAI-VFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
Query: 82 AAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPC-- 139
+ + C + L + C + L + + RY A+ Y C
Sbjct: 93 GGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRR 149
Query: 140 AAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVV-----V 194
A+++ A W LA A + P + + C++ PD F++ +VV
Sbjct: 150 VALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSI-SNPD-------FVIYSSVVSFYLPF 201
Query: 195 GATHLVYLRLLFFIHDRRKMR------------------------PARL----VPAVSHD 226
G T LVY R+ + RR+ R PA L ++ D
Sbjct: 202 GVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQD 261
Query: 227 WTFHGPG---ATGQAAANWTAGFGRGPT--PPALVGIRPAGPGRGARRLLV--LEEFKT- 278
GPG G+ PT P + +R GR + L + L+
Sbjct: 262 TALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVP 321
Query: 279 --EKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPV 336
EK+ +M V F++ W P+ + L + V +A+ WL + + +NPV
Sbjct: 322 LREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPV 381
Query: 337 VCFLFNRELRDCFRAQFPC 355
+ FN E R F C
Sbjct: 382 IYTTFNIEFRKAFLKILSC 400
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 70.9 bits (172), Expect = 2e-12
Identities = 96/366 (26%), Positives = 146/366 (39%), Gaps = 44/366 (12%)
Query: 5 SEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLAD 64
S PGGSG AA L +++ ++ A N L LI + +L + L+ L +D
Sbjct: 21 SAPGGSGWVAAA--------LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSD 72
Query: 65 GLRALACLPAVMLAAR--RAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYL 122
+ L +P ML A R A G C L + C + L + + RYL
Sbjct: 73 LMVGLVVMPPAMLNALYGRWVLARGL------CLLWTAFDVMCCSASILNLCLISLDRYL 126
Query: 123 AIAHHRFYAERLAGWPCAAM-LVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAP 181
I Y R+ P A+ LV AW+LA A+F P+L G + A RP P
Sbjct: 127 LILSPLRYKLRMT--PLRALALVLGAWSLAALASFLPLLLGWHELGHA------RPP-VP 177
Query: 182 GALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAA-A 240
G L L V+ A+ L + F R++ A TG A+ A
Sbjct: 178 GQCRLLASLPFVLVASGLTF----FLPSGAICFTYCRILLAARKQAVQVASLTTGMASQA 233
Query: 241 NWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTL-LFLLLWGP 299
+ T R P P G+ A +RRL K K + + L +F + W P
Sbjct: 234 SETLQVPRTPRP----GVESAD----SRRLATKHSRKALK--ASLTLGILLGMFFVTWLP 283
Query: 300 YVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSP 359
+ VA+ ++ + + WL + + +NP++ LF R+ + PC + P
Sbjct: 284 FFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCP 341
Query: 360 RTTQAT 365
R QA+
Sbjct: 342 RERQAS 347
>gi|28875799 cholecystokinin B receptor [Homo sapiens]
Length = 447
Score = 70.9 bits (172), Expect = 2e-12
Identities = 87/372 (23%), Positives = 146/372 (39%), Gaps = 31/372 (8%)
Query: 12 GGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALAC 71
G L +++ +++ +S+ GN+L +++ R L LL L ++D L A+AC
Sbjct: 48 GTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVAC 107
Query: 72 LPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYA 131
+P +L G + CK +++L + + L+ + + RY AI A
Sbjct: 108 MPFTLLPNLMGTFIFGT----VICKAVSYLMGVSVSVSTLSLVAIALERYSAICRP-LQA 162
Query: 132 ERLAGWPCAAMLVCAAWALA--LAAAFPPVLDGGGDDEDAPCALEQRPDGA---PGALGF 186
AA ++ A W L+ L +P + + P ++
Sbjct: 163 RVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLL 222
Query: 187 LLLLAVVVGATHLV---------YLRLLFF----IHDRRKMRPARLVPAVSHDWTFHGP- 232
LLLL + G V YL L F + ++R +P H P
Sbjct: 223 LLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPE 282
Query: 233 -GATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTL 291
GA G+ + R L + GPG G+R + +KR+ +M + +
Sbjct: 283 TGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQA--KLLAKKRVVRMLLVIVV 340
Query: 292 LFLLLWGPYVVASYLRVLVRPG---AVPQAYLTASVWLTFAQAGINPVV-CFLFNRELRD 347
LF L W P A+ R PG A+ A ++ L++A A +NP+V CF+ R +
Sbjct: 341 LFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQA 400
Query: 348 CFRAQFPCCQSP 359
C CC P
Sbjct: 401 CLETCARCCPRP 412
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 70.5 bits (171), Expect = 2e-12
Identities = 86/410 (20%), Positives = 149/410 (36%), Gaps = 69/410 (16%)
Query: 3 NASEP--GGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDL 60
N S P G G + L+LL+ V + GNVL + + RE++L YL++ L
Sbjct: 17 NWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSL 76
Query: 61 CLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTR 120
+AD L A +P V+ + C + L + C + L + + R
Sbjct: 77 AVADLLVATLVMPWVVY----LEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDR 132
Query: 121 YLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGA 180
Y A+A Y R + +++ W L+ + P+L G + + C +
Sbjct: 133 YTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISC-PLLFGLNNADQNECIIAN----- 186
Query: 181 PGALGFLLLLAVVVG--ATHLVYLRLLFFIHDRRK----MRPARL--------------- 219
P + + +++ V T LVY+++ + RRK R +R
Sbjct: 187 PAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARR 246
Query: 220 ----------------------VPAVSHDWTF-----HGPGATGQAAANWTAGFGRGPTP 252
+P H T HG +T + A G
Sbjct: 247 AQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKN-GHAKDH 305
Query: 253 PALVGI-----RPAGPGRGARRLLVLEEF--KTEKRLCKMFYAVTLLFLLLWGPYVVASY 305
P + I P G R + + + + + EK+ +M V +F++ W P+ +
Sbjct: 306 PKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHI 365
Query: 306 LRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
L + P Y +A WL + + +NP++ FN E R F C
Sbjct: 366 LNIHCDCNIPPVLY-SAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
>gi|57165371 G protein-coupled receptor 61 [Homo sapiens]
Length = 451
Score = 68.6 bits (166), Expect = 9e-12
Identities = 91/361 (25%), Positives = 138/361 (38%), Gaps = 51/361 (14%)
Query: 14 EAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLP 73
+ A+ + L + LL ++AGN +I + +L + + + LCL D L AL +P
Sbjct: 38 DVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRK--FVFVFHLCLVDLLAALTLMP 95
Query: 74 AVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAER 133
ML++ +A A G + C+L FL+ F A + + V RY + H Y R
Sbjct: 96 LAMLSS--SALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVR 153
Query: 134 LAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAP-----CALEQRPDGAPGALGFLL 188
+ A++LV W ALA A PVL +E AP C+L+ +
Sbjct: 154 MTLGLVASVLV-GVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHS------AYCQ 206
Query: 189 LLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGR 248
L VV + + LL + R AR V A+ H
Sbjct: 207 LFVVVFAVLYFLLPLLLILVVYCSMFRVAR-VAAMQH----------------------- 242
Query: 249 GPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMF----YAVTLL-----FLLLWGP 299
GP P + R +R +V + + F AV LL FLL W P
Sbjct: 243 GPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLP 302
Query: 300 YV-VASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQS 358
Y Y+ + +P + Q + W+ + NP NR++R QF C
Sbjct: 303 YFSFHLYVALSAQPISTGQVE-SVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFK 361
Query: 359 P 359
P
Sbjct: 362 P 362
>gi|222080095 orexin receptor 1 [Homo sapiens]
Length = 425
Score = 67.8 bits (164), Expect = 2e-11
Identities = 85/359 (23%), Positives = 138/359 (38%), Gaps = 56/359 (15%)
Query: 22 LATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARR 81
+A + V+L GN L L + R + Y +++L LAD L CLPA +L
Sbjct: 50 IAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT 109
Query: 82 AAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFY---AERLAGWP 138
+ G AL CK++ +L A+ A L + + R+ AI H + A R G
Sbjct: 110 ESWLFG---HAL-CKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARG-- 163
Query: 139 CAAMLVCAAWALALAAAFP--PVLDGGGDDED--------APCALEQRPDGAP---GALG 185
+ WA++LA P V++ + + C D P +
Sbjct: 164 ----SILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCF 219
Query: 186 FLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAG 245
F++ +G + Y ++ RK+ W PG T NW
Sbjct: 220 FIVTYLAPLGLMAMAYFQIF------RKL------------WGRQIPGTTSALVRNWKRP 261
Query: 246 FGR-GPTPPALVGIRPAGPGRGARRLLV-LEEFKTEKRLCKMFYAVTLLFLLLWGPYVVA 303
+ G L G P AR L +++ + ++ KM V L+F L + P V
Sbjct: 262 SDQLGDLEQGLSG----EPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVL 317
Query: 304 SYLRVL------VRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCC 356
+ L+ + A T S WL +A + NP++ + + R+ F+A F CC
Sbjct: 318 NVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCC 376
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 66.6 bits (161), Expect = 3e-11
Identities = 89/415 (21%), Positives = 151/415 (36%), Gaps = 80/415 (19%)
Query: 4 ASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLA 63
A+ GG+ G AA + A ++LL+ ++ GN L L V + SL + LL+L ++
Sbjct: 20 AAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAIS 79
Query: 64 DGLRALACLPAVM--LAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRY 121
D L C+P + + R G CKL + L C +AF ++ + R+
Sbjct: 80 DFLVGAFCIPLYVPYVLTGRWTFGRGL------CKLWLVVDYLLCTSSAFNIVLISYDRF 133
Query: 122 LAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPV-----LDGGGDDEDAPCALEQR 176
L++ Y + A + W LA P + L GG + C E
Sbjct: 134 LSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFF 193
Query: 177 PDGAPGALGFLLLLAVVVGAT---HLVYLRLLFFIHDRRKMR--------------PARL 219
+ FL+ + + T + + L +++ +R+ R P
Sbjct: 194 YNWY-----FLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEA 248
Query: 220 VPAV--------------SHDWTFH----GPGATGQAAANWTAGFGRG----PTPPALVG 257
P+ H G A G A T G G G +P + G
Sbjct: 249 QPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSG 308
Query: 258 I------RPAGPGRGA----------RRLLVLEEFKTEK-------RLCKMFYAVTLLFL 294
RP RG+ +R+ ++ + T++ ++ K + +F
Sbjct: 309 SSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFG 368
Query: 295 LLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCF 349
L W PY + +R VP + S WL +A + +NPV+ L + R F
Sbjct: 369 LCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAF 423
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 66.2 bits (160), Expect = 4e-11
Identities = 76/347 (21%), Positives = 133/347 (38%), Gaps = 49/347 (14%)
Query: 25 LSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAA 84
L+L+ +++AGN L + + + L + YL++ L LAD A+A +P V +
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 85 AAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLV 144
G C + + + C + L + + RYL I Y R G C A ++
Sbjct: 148 WIF---GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG-KCMAKMI 203
Query: 145 CAAWALALAAAFPPVLDGGGD-DEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLR 203
+ W L+ + PP+ + ++D C + Q G+ + V A ++
Sbjct: 204 LSVWLLSASITLPPLFGWAQNVNDDKVCLISQ-------DFGYTIYSTAV--AFYIPMSV 254
Query: 204 LLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGI----- 258
+LF + K A AA + GF R P +++ +
Sbjct: 255 MLFMYYQIYK-------------------AARKSAAKHKFPGFPR-VEPDSVIALNGIVK 294
Query: 259 --RPAGPGRGARRLLVLEE-----FKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLV- 310
+ RLL E FK E++ + F + W P+ + S R +
Sbjct: 295 LQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
Query: 311 --RPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
+P +WL +A + INP + FNR+LR +R+ C
Sbjct: 355 GTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 66.2 bits (160), Expect = 4e-11
Identities = 76/347 (21%), Positives = 133/347 (38%), Gaps = 49/347 (14%)
Query: 25 LSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAA 84
L+L+ +++AGN L + + + L + YL++ L LAD A+A +P V +
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 85 AAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLV 144
G C + + + C + L + + RYL I Y R G C A ++
Sbjct: 148 WIF---GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG-KCMAKMI 203
Query: 145 CAAWALALAAAFPPVLDGGGD-DEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLR 203
+ W L+ + PP+ + ++D C + Q G+ + V A ++
Sbjct: 204 LSVWLLSASITLPPLFGWAQNVNDDKVCLISQ-------DFGYTIYSTAV--AFYIPMSV 254
Query: 204 LLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGI----- 258
+LF + K A AA + GF R P +++ +
Sbjct: 255 MLFMYYQIYK-------------------AARKSAAKHKFPGFPR-VEPDSVIALNGIVK 294
Query: 259 --RPAGPGRGARRLLVLEE-----FKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLV- 310
+ RLL E FK E++ + F + W P+ + S R +
Sbjct: 295 LQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
Query: 311 --RPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
+P +WL +A + INP + FNR+LR +R+ C
Sbjct: 355 GTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 66.2 bits (160), Expect = 4e-11
Identities = 76/347 (21%), Positives = 133/347 (38%), Gaps = 49/347 (14%)
Query: 25 LSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAA 84
L+L+ +++AGN L + + + L + YL++ L LAD A+A +P V +
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 85 AAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLV 144
G C + + + C + L + + RYL I Y R G C A ++
Sbjct: 148 WIF---GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG-KCMAKMI 203
Query: 145 CAAWALALAAAFPPVLDGGGD-DEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLR 203
+ W L+ + PP+ + ++D C + Q G+ + V A ++
Sbjct: 204 LSVWLLSASITLPPLFGWAQNVNDDKVCLISQ-------DFGYTIYSTAV--AFYIPMSV 254
Query: 204 LLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGI----- 258
+LF + K A AA + GF R P +++ +
Sbjct: 255 MLFMYYQIYK-------------------AARKSAAKHKFPGFPR-VEPDSVIALNGIVK 294
Query: 259 --RPAGPGRGARRLLVLEE-----FKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLV- 310
+ RLL E FK E++ + F + W P+ + S R +
Sbjct: 295 LQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
Query: 311 --RPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 355
+P +WL +A + INP + FNR+LR +R+ C
Sbjct: 355 GTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 65.5 bits (158), Expect = 8e-11
Identities = 75/343 (21%), Positives = 135/343 (39%), Gaps = 40/343 (11%)
Query: 20 LKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVM--- 76
L L L L+ + A N+L I+R R+ HR P+ L+ + ++D L A +P +
Sbjct: 42 LILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHE 101
Query: 77 LAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAG 136
L+ RR G C+L L C + + + + + RY +I H Y R
Sbjct: 102 LSGRRWQL------GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR- 154
Query: 137 WPCAA-MLVCAAWALALAAAFPPVLDGGGD---DEDAPCALEQRPDGAPGAL--GFLLLL 190
C + +++ WAL+ + P+L G G+ + C + + P A + F L L
Sbjct: 155 -KCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPL 213
Query: 191 AVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGP 250
VV+ +Y F + R+ + + AV + P
Sbjct: 214 CVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVR----------- 262
Query: 251 TPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLV 310
A V +P G ++ E+R M + +F+L W P+ + + L
Sbjct: 263 --HATVTFQPEGDTWREQK---------EQRAALMVGILIGVFVLCWIPFFLTELISPLC 311
Query: 311 RPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQF 353
+P + + +WL ++ + NP++ FN+ F+ F
Sbjct: 312 SCD-IPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF 353
>gi|4557865 somatostatin receptor 5 [Homo sapiens]
Length = 364
Score = 63.5 bits (153), Expect = 3e-10
Identities = 87/365 (23%), Positives = 146/365 (40%), Gaps = 78/365 (21%)
Query: 3 NASEPGGSGGG-----------EAAALGLKLATLSLLLCVS-LAGNVLFALLIVRERSLH 50
NAS PG + GG A A + + L LL+C + L GN L +++R +
Sbjct: 13 NASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMK 72
Query: 51 RAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAA 110
+L+L +AD L L LP LA + AA+ P G + C+L+ L + F +
Sbjct: 73 TVTNIYILNLAVADVLYMLG-LP--FLATQNAASFW--PFGPVLCRLVMTLDGVNQFTSV 127
Query: 111 FLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAP 170
F L + V RYLA+ H + R A + AAW L+L + P ++ +
Sbjct: 128 FCLTVMSVDRYLAVV-HPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTC 186
Query: 171 CALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFH 230
A P G GA+ F++ AV+ L+ + L + +
Sbjct: 187 NASWPEPVGLWGAV-FIIYTAVLGFFAPLLVICLCYLL---------------------- 223
Query: 231 GPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVT 290
+V +R AG G R ++E+++ +M V
Sbjct: 224 -----------------------IVVKVRAAGVRVGCVRR------RSERKVTRMVLVVV 254
Query: 291 LLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVW-----LTFAQAGINPVVCFLFNREL 345
L+F W P+ + + + V A+PQ +A ++ L++A + NPV+ +
Sbjct: 255 LVFAGCWLPFFTVNIVNLAV---ALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNF 311
Query: 346 RDCFR 350
R F+
Sbjct: 312 RQSFQ 316
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 63.5 bits (153), Expect = 3e-10
Identities = 78/351 (22%), Positives = 138/351 (39%), Gaps = 52/351 (14%)
Query: 15 AAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPA 74
A ++GL L L ++ GN+L L + R L Y +++L +AD L + LP
Sbjct: 45 AISVGLVLGAFILF---AIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPF 101
Query: 75 VMLAARRAAAAAGAPPGALG---CKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYA 131
+AA LG C + A + L C + L + + RY+ + + Y
Sbjct: 102 -------SAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYP 154
Query: 132 ERLAGWPCAAMLVCAAWALALAAAFPPVLDGG--GDDEDAPCALEQRPDGAP-GALG-FL 187
L A + + + W L+ + P+L ++D C + + P A +LG F
Sbjct: 155 T-LVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFY 213
Query: 188 LLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVS---------HDWTFHGPGATGQA 238
+ LAV++ ++Y R+ K A ++ +S H FH +
Sbjct: 214 IPLAVIL----VMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTK 269
Query: 239 AANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWG 298
A +G P + + ++ L +F EK+ K V +F+L W
Sbjct: 270 A--------KGHNPRSSIAVK-------------LFKFSREKKAAKTLGIVVGMFILCWL 308
Query: 299 PYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCF 349
P+ +A L L P A WL + + +NP++ ++E + F
Sbjct: 309 PFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 359
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 63.2 bits (152), Expect = 4e-10
Identities = 91/380 (23%), Positives = 147/380 (38%), Gaps = 53/380 (13%)
Query: 2 ANASEPG--GSGG---GEAAALGLKLAT--------LSLLLCVSLAGNVLFALLIVRERS 48
++A EPG G+GG G AA GL ++ L+ + +++AGN+L L + R
Sbjct: 67 SSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRH 126
Query: 49 LHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFH 108
L Y +++L +AD L + LP +A A G C + A + L C
Sbjct: 127 LQTVTNYFIVNLAVADLLLSATVLP---FSATMEVLGFWA-FGRAFCDVWAAVDVLCCTA 182
Query: 109 AAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDED 168
+ L + V RY+ + H Y + AA+L W +AL + P+L G E
Sbjct: 183 SILSLCTISVDRYVGVRHSLKYPAIMTERKAAAIL-ALLWVVALVVSVGPLL---GWKEP 238
Query: 169 AP-----CALEQRPDGA--PGALGFLLLLAVVVGATHLVYL------RLLFFIHDRRKMR 215
P C + + A F L +AV+V VY+ R L R + +
Sbjct: 239 VPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGK 298
Query: 216 PARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEE 275
+ +V + H GA A +G T + + +R L +
Sbjct: 299 ASEVVLRI------HCRGAATGADGAHGMRSAKGHTFRSSLSVR-------------LLK 339
Query: 276 FKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINP 335
F EK+ K V +F+L W P+ L L + WL + + +NP
Sbjct: 340 FSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNP 399
Query: 336 VVCFLFNRELRDCFRAQFPC 355
++ +RE + F C
Sbjct: 400 LIYPCSSREFKRAFLRLLRC 419
>gi|32261309 G protein-coupled receptor 135 [Homo sapiens]
Length = 494
Score = 62.8 bits (151), Expect = 5e-10
Identities = 89/338 (26%), Positives = 125/338 (36%), Gaps = 58/338 (17%)
Query: 16 AALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAV 75
AA+ + L L+ +S GN +IV+ R L +L L L+D L AL CLPA
Sbjct: 101 AAVAAQALVLLLIFLLSSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAA 160
Query: 76 ML----AARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYA 131
L +A AA A P C F ++ F + + + + RY AI R
Sbjct: 161 FLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIV--RPPR 218
Query: 132 ERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAP-----CALEQRPDGAPGALGF 186
E++ G A L+ AW AL + P L G + A C PD P LG
Sbjct: 219 EKI-GRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPD--PAQLGA 275
Query: 187 LLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGF 246
+ +VV A +L+ L+ F H + RL
Sbjct: 276 AFSVGLVV-ACYLLPFLLMCFCH-YHICKTVRL--------------------------- 306
Query: 247 GRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYL 306
+ V +RP AR L E +T + M V + WGPY L
Sbjct: 307 -------SDVRVRPV--NTYARVLRFFSEVRTATTVLIMIVFV----ICCWGPYCFLVLL 353
Query: 307 RVL--VRPGAVPQAYLTASVWLTFAQAGINPVVCFLFN 342
+ P +VWLT+A INPV+ + N
Sbjct: 354 AAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
>gi|4758474 G protein-coupled receptor 10 [Homo sapiens]
Length = 370
Score = 62.8 bits (151), Expect = 5e-10
Identities = 45/139 (32%), Positives = 64/139 (46%), Gaps = 6/139 (4%)
Query: 19 GLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLA 78
GL + S+++ V L GN L L+I R R LH +L+ +L L+D L AC+P L
Sbjct: 61 GLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVP---LT 117
Query: 79 ARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWP 138
A G G C L+ FL + + + F L + V RY+ + H R
Sbjct: 118 LAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHP---LRRRISLR 174
Query: 139 CAAMLVCAAWALALAAAFP 157
+A V A WAL+ A P
Sbjct: 175 LSAYAVLAIWALSAVLALP 193
>gi|5174595 melatonin receptor 1B [Homo sapiens]
Length = 362
Score = 61.6 bits (148), Expect = 1e-09
Identities = 65/230 (28%), Positives = 89/230 (38%), Gaps = 27/230 (11%)
Query: 4 ASEPGGSGGGEA----------AALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAP 53
A PG SG G A A L A L + V + GN+L L ++R R L A
Sbjct: 17 AVRPGWSGAGSARPSRTPRPPWVAPALS-AVLIVTTAVDVVGNLLVILSVLRNRKLRNAG 75
Query: 54 YYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLL 113
L+ L LAD + A P +++A A G CK AF+ L + F +
Sbjct: 76 NLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEE----HCKASAFVMGLSVIGSVFNI 131
Query: 114 LGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGG--GDDEDAPC 171
+ + RY I H Y W + +C W L + A P G D C
Sbjct: 132 TAIAINRYCYICHSMAYHRIYRRWH-TPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSC 190
Query: 172 ALEQRPD----GAPGALGFLLLLAVVVGATHLVYLRL-LFFIHDRRKMRP 216
Q A + FLL +AVV YLR+ + + RRK +P
Sbjct: 191 TFIQTASTQYTAAVVVIHFLLPIAVV----SFCYLRIWVLVLQARRKAKP 236
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 61.2 bits (147), Expect = 1e-09
Identities = 84/361 (23%), Positives = 142/361 (39%), Gaps = 24/361 (6%)
Query: 16 AALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLP-- 73
A +GL +A + LL+ +AGNVL + I + L ++ L AD + L +P
Sbjct: 59 AGMGLLMALIVLLI---VAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFG 115
Query: 74 AVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAER 133
A ++ R G+ C+L + L + L + + RYLAI F +
Sbjct: 116 ATIVVWGRWEY------GSFFCELWTSVDVLCVTASIETLCVIALDRYLAIT-SPFRYQS 168
Query: 134 LAGWPCAAMLVCAAWALALAAAFPPVLD---GGGDDEDAPCALEQRPDGAPGALGFLLLL 190
L A LVC WA++ +F P+L DE C + + + +
Sbjct: 169 LLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIAS 228
Query: 191 AVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGP 250
+VV L + ++ R + + + + + GP + + P
Sbjct: 229 SVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRF-LGGPARPPSPSPSPVPAPAPPP 287
Query: 251 TPP---ALVGIRPAGPGR-GARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYL 306
PP A P GR G RR L + +K L K + +F L W P+ +A+ +
Sbjct: 288 GPPRPAAAAATAPLANGRAGKRRPSRLVALREQKAL-KTLGIIMGVFTLCWLPFFLANVV 346
Query: 307 RVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCC-QSPRTTQAT 365
+ R VP WL +A + NP++ + + + R F+ C ++ R AT
Sbjct: 347 KAFHRE-LVPDRLFVFFNWLGYANSAFNPII-YCRSPDFRKAFQGLLCCARRAARRRHAT 404
Query: 366 H 366
H
Sbjct: 405 H 405
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.329 0.142 0.462
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,325,108
Number of Sequences: 37866
Number of extensions: 774099
Number of successful extensions: 4682
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 207
Number of HSP's successfully gapped in prelim test: 376
Number of HSP's that attempted gapping in prelim test: 3884
Number of HSP's gapped (non-prelim): 855
length of query: 375
length of database: 18,247,518
effective HSP length: 104
effective length of query: 271
effective length of database: 14,309,454
effective search space: 3877862034
effective search space used: 3877862034
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.