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Search of human proteins with 94536803
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94536803 transmembrane protein 16K [Homo sapiens]
(660 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94536803 transmembrane protein 16K [Homo sapiens] 1316 0.0
gi|55741655 anoctamin 8 [Homo sapiens] 229 8e-60
gi|145207958 transmembrane protein 16G isoform NGEP long [Homo s... 194 2e-49
gi|218084958 anoctamin 4 [Homo sapiens] 184 3e-46
gi|156766084 transmembrane protein 16C [Homo sapiens] 178 1e-44
gi|218156307 anoctamin 6 isoform c [Homo sapiens] 172 7e-43
gi|218156305 anoctamin 6 isoform c [Homo sapiens] 172 7e-43
gi|218156303 anoctamin 6 isoform b [Homo sapiens] 172 7e-43
gi|218156299 anoctamin 6 isoform a [Homo sapiens] 172 7e-43
gi|145611446 tumor protein p53 inducible protein 5 [Homo sapiens] 157 2e-38
gi|218081589 anoctamin 5 isoform b [Homo sapiens] 153 6e-37
gi|47106048 anoctamin 5 isoform a [Homo sapiens] 153 6e-37
gi|209862785 anoctamin 2 [Homo sapiens] 139 8e-33
gi|194306539 anoctamin 1, calcium activated chloride channel [Ho... 129 1e-29
gi|169161033 PREDICTED: hypothetical protein [Homo sapiens] 38 0.034
gi|239747244 PREDICTED: hypothetical protein [Homo sapiens] 38 0.034
gi|239741065 PREDICTED: hypothetical protein [Homo sapiens] 38 0.034
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 32 2.4
gi|24497620 signal recognition particle 68kDa [Homo sapiens] 31 4.2
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 30 7.1
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 30 7.1
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 30 7.1
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 30 7.1
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 30 7.1
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 30 7.1
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 30 7.1
>gi|94536803 transmembrane protein 16K [Homo sapiens]
Length = 660
Score = 1316 bits (3405), Expect = 0.0
Identities = 660/660 (100%), Positives = 660/660 (100%)
Query: 1 MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYE 60
MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYE
Sbjct: 1 MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYE 60
Query: 61 QETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLT 120
QETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLT
Sbjct: 61 QETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLT 120
Query: 121 MAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALK 180
MAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALK
Sbjct: 121 MAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALK 180
Query: 181 KLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDY 240
KLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDY
Sbjct: 181 KLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDY 240
Query: 241 DKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGK 300
DKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGK
Sbjct: 241 DKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGK 300
Query: 301 EEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLY 360
EEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLY
Sbjct: 301 EEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLY 360
Query: 361 VPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIA 420
VPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIA
Sbjct: 361 VPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIA 420
Query: 421 FVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYE 480
FVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYE
Sbjct: 421 FVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYE 480
Query: 481 QVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRV 540
QVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRV
Sbjct: 481 QVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRV 540
Query: 541 FKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEH 600
FKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEH
Sbjct: 541 FKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEH 600
Query: 601 ALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT 660
ALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT
Sbjct: 601 ALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT 660
>gi|55741655 anoctamin 8 [Homo sapiens]
Length = 1232
Score = 229 bits (583), Expect = 8e-60
Identities = 146/396 (36%), Positives = 214/396 (54%), Gaps = 18/396 (4%)
Query: 70 YLVGASKIRMLLGAEAVGL---VKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQF 126
+ V A+ +L GA+ +GL VK R F+ ++ + F T E Q
Sbjct: 109 FFVTATYESLLRGADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELR-FFTSQERQS 167
Query: 127 IIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTW 186
II+ L+NLRAK + + + + ++ L GI+ QVFP+H+ L +L +W
Sbjct: 168 IIRFWLQNLRAKQGEALHN---VRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSW 224
Query: 187 YTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKY--- 243
+ + QP+D I YFG IA+YF +L ++T A++ AV G Y F D
Sbjct: 225 -VQAVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVS 283
Query: 244 -VIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRK-FEEPRPGFHGVLGINSITGKE 301
V+FA FN+IWST+ LE WKR A + Y+WGTL + EEPRP F GV I+ IT E
Sbjct: 284 CVVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAE 343
Query: 302 EPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYV 361
E YP +KR L LVSLP CL +M+ F ++ L + + ++
Sbjct: 344 EFYYPPWKRLLFQLLVSLPLCLACLVCVFLLMLGCFQLQELVLSV-----KGLPRLARFL 398
Query: 362 PSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAF 421
P ++ A+++ + Y+ A +L EN+RLESAY+ HLI+KV++F F+N + SLFYI F
Sbjct: 399 PKVMLALLVSVSAEGYKKLAIWLNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGF 458
Query: 422 VLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQR 457
LKDM+ L++ LATLLIT Q L + E P+ +R
Sbjct: 459 YLKDMERLKEMLATLLITRQFLQNVREVLQPHLYRR 494
Score = 136 bits (343), Expect = 5e-32
Identities = 71/160 (44%), Positives = 99/160 (61%), Gaps = 1/160 (0%)
Query: 481 QVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRV 540
Q LE M Y TF DY E+F+QFGYV LFS +PLAA A++NN E+ SDA K+C
Sbjct: 731 QAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTG 790
Query: 541 FKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFP-ESKADLILIVVAVE 599
+RPF + +IG WQ E M V+++V NC LIG Q+ +FP S I+ VV +E
Sbjct: 791 LQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPEAAIVSVVVLE 850
Query: 600 HALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQ 639
H L LK+++ AIPD P + ++A+LE++ EA K+ +
Sbjct: 851 HFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHE 890
>gi|145207958 transmembrane protein 16G isoform NGEP long [Homo
sapiens]
Length = 933
Score = 194 bits (493), Expect = 2e-49
Identities = 167/689 (24%), Positives = 285/689 (41%), Gaps = 162/689 (23%)
Query: 113 DNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLL--RRLLTSGIVIQV 170
DN D F T + I+ L EK K+LL +LL G++
Sbjct: 244 DNQDTFFTSTKRHQILFEILAKTPYGHEK-------------KNLLGIHQLLAEGVLSAA 290
Query: 171 FPLHDSEALKKLEDTWYTRFAL---------------KYQPIDSIRGYFGETIALYFGFL 215
FPLHD E R KYQP+D +R YFGE +ALYF +L
Sbjct: 291 FPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWL 350
Query: 216 EYFTFALIPMAVIGL-----------------------------------PYYLFVWE-- 238
++T L+P AV+G P++L
Sbjct: 351 GFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACA 410
Query: 239 --------DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHG 290
D+ V F+ F +W+ ++LE WKR A + YRW + E PRP F
Sbjct: 411 LAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAA 470
Query: 291 ---VLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLH 347
+ N ITG++EP +P R R+ S+ V + + ++ I + A+ +
Sbjct: 471 SAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVS 530
Query: 348 ENSGS---EWTS-VLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILK 403
+ + W S + S++ + I I++++Y A LT WE HR ++ +++ LK
Sbjct: 531 RSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLK 590
Query: 404 VLVFNFLNCFASLFYIAFV----------------LKDMKL--------LRQSLATLLIT 439
V +F F+N ++S YIAF +++ + L Q L +++
Sbjct: 591 VFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVG 650
Query: 440 SQILNQIMESFLPY---WLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFD 496
Q++N + E +P W Q K +R K++ A +E + E+ G FD
Sbjct: 651 KQVINNMQEVLIPKLKGWWQ-KFRLRSKKRKAGASAGASQGPWED---DYELVPCEGLFD 706
Query: 497 DYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQ 556
+YLE+ LQFG+V++F PLA FA+LNN+ E+ DA K ++RP +E + +IG+W
Sbjct: 707 EYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWF 766
Query: 557 LAFETMSVISVVTNCALIGMSPQV------------------------------------ 580
++ ++V++N L+ S
Sbjct: 767 HILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRT 826
Query: 581 ---------NAVFPESKADLILIVVA----VEHALLALKFILAFAIPDKPRHIQMKLARL 627
+ + ++ +L+ I +A EH + ++ +L +PD P +++K+ R
Sbjct: 827 CRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKRE 886
Query: 628 EFESLEALKQQQMKLVTENLKEEPMESGK 656
+ + +AL + ++ T K+E E +
Sbjct: 887 YYLAKQALAENEVLFGTNGTKDEQPEGSE 915
>gi|218084958 anoctamin 4 [Homo sapiens]
Length = 920
Score = 184 bits (466), Expect = 3e-46
Identities = 162/571 (28%), Positives = 249/571 (43%), Gaps = 135/571 (23%)
Query: 114 NNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPL 173
N + F A I+ H L+ ++ ++ K K L RLLT+G FPL
Sbjct: 215 NKETFFNNATRSRIVHHILQRIKYEEGK------------NKIGLNRLLTNGSYEAAFPL 262
Query: 174 HDSEALKK--------------LEDTWYTRFA-LKYQPIDSIRGYFGETIALYFGFLEYF 218
H+ K L + W + KYQP+D +R YFGE I LYF +L ++
Sbjct: 263 HEGSYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWY 322
Query: 219 TFALIPMAVIGLPYYLF---------------------VWEDYDKY-------------- 243
T L P A IGL +L+ + DKY
Sbjct: 323 TGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAK 382
Query: 244 ----------VIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLG 293
V FA F +W+TV LE WKR A + Y W + + + EE RP F
Sbjct: 383 VTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYS 442
Query: 294 ----INSITGKEEPLYPSYKRQLRIYLVSLP--FVCLCLYFS-LYVMMIYFDMEV----- 341
+N I+GK EP Y ++ + +VS F +C+ + ++ ++IY + V
Sbjct: 443 KKERMNPISGKPEP-YQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAA 501
Query: 342 --WALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNH 399
WAL + NS T + I +I ++N LY A LT+ E R ES ++N
Sbjct: 502 FKWAL-IRNNSQVATTGTAV----CINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENS 556
Query: 400 LILKVLVFNFLNCFASLFYIAFVL--------KDMKLLRQ-----------------SLA 434
LK+ +F F+N +S FYIAF L ++L+ + +
Sbjct: 557 FTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMG 616
Query: 435 TLLITSQILNQIMESFLP----YWLQRK----HGVRVKRKVQALKADIDATLYEQVILEK 486
+++ Q N ME P +W +RK HG +RK+ + + D L +
Sbjct: 617 IIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHG--PERKISFPQWEKDYNL-------Q 667
Query: 487 EMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFS 546
M Y G FD+YLE+ LQFG+ ++F +PLA A+LNN E+ DA K ++RP +
Sbjct: 668 PMNAY-GLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLA 726
Query: 547 EPSANIGVWQLAFETMSVISVVTNCALIGMS 577
+ +IG+W E + ++SV+TN +I ++
Sbjct: 727 SRAKDIGIWYGILEGIGILSVITNAFVIAIT 757
Score = 33.1 bits (74), Expect = 0.84
Identities = 11/58 (18%), Positives = 34/58 (58%)
Query: 592 ILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKE 649
+ ++ EH + +K ++++ IPD P+ ++ ++ R ++ E + + +++ + + KE
Sbjct: 850 LAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKE 907
>gi|156766084 transmembrane protein 16C [Homo sapiens]
Length = 981
Score = 178 bits (452), Expect = 1e-44
Identities = 166/567 (29%), Positives = 247/567 (43%), Gaps = 128/567 (22%)
Query: 113 DNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFP 172
+N D F + A I+ H LE R K E I K +R+L+ +G I FP
Sbjct: 294 NNKDTFFSNATRSRIVYHMLE--RTKYENGI----------SKVGIRKLINNGSYIAAFP 341
Query: 173 LHD-----SEALKK---------LEDTWYTRFAL--KYQPIDSIRGYFGETIALYFGFLE 216
H+ S+ +K L + W R+ + K+QP+D IR YFGE I LYF +L
Sbjct: 342 PHEGAYKSSQPIKTHGPQNNRHLLYERW-ARWGMWYKHQPLDLIRLYFGEKIGLYFAWLG 400
Query: 217 YFTFALIPMAVIGLP---YYLFVWED---------------------------------Y 240
++T LIP A++GL Y LF + Y
Sbjct: 401 WYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIY 460
Query: 241 DKY---------VIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGV 291
K V FA F IW+TV LE WKR + +TY W + + + E RP F
Sbjct: 461 AKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAK 520
Query: 292 LG----INSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLH 347
+N ITGK EP PS + R+ LVS+ + + V+ F + V+ L +
Sbjct: 521 YYKMEIVNPITGKPEPHQPSSDKVTRL-LVSVSGI---FFMISLVITAVFGVVVYRLVVM 576
Query: 348 ENSGS-EWTSVLLY-------VPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNH 399
E S +W + Y I I+I ++N Y A LT+ E R ES ++N
Sbjct: 577 EQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENS 636
Query: 400 LILKVLVFNFLNCFASLFYIAFVL--------KDMKL-----------------LRQSLA 434
LK+ +F F+N +S+FYIAF L K KL L +
Sbjct: 637 FALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMG 696
Query: 435 TLLITSQILNQIMESFLP----YWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGT 490
++ QI N ME P +W + K +KR + D +E + M
Sbjct: 697 VIMFLKQIWNNFMELGYPLIQNWWSRHK----IKRGIH----DASIPQWENDWNLQPMNL 748
Query: 491 YLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSA 550
+ G D+YLE+ LQFG+ ++F +PLA A+LNN E+ DA K ++RP +
Sbjct: 749 H-GLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARAT 807
Query: 551 NIGVWQLAFETMSVISVVTNCALIGMS 577
+IG+W E + +++V+TN +I ++
Sbjct: 808 DIGIWLGILEGIGILAVITNAFVIAIT 834
Score = 32.7 bits (73), Expect = 1.1
Identities = 14/65 (21%), Positives = 37/65 (56%), Gaps = 4/65 (6%)
Query: 592 ILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEP 651
+ ++ EH + +K +A+ IPD P+ + ++ R ++ E + + ++ E+L+++
Sbjct: 914 LAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAEL----EHLQQQR 969
Query: 652 MESGK 656
+SG+
Sbjct: 970 RKSGQ 974
>gi|218156307 anoctamin 6 isoform c [Homo sapiens]
Length = 929
Score = 172 bits (437), Expect = 7e-43
Identities = 145/525 (27%), Positives = 239/525 (45%), Gaps = 115/525 (21%)
Query: 158 LRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFALKYQPIDSIRGYF 204
+ RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+
Sbjct: 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKY--------------------- 243
GE I +YF +L Y+T L+ AV+G+ +L+ + + D
Sbjct: 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
Query: 244 ---------------------------VIFASFNLIWSTVILELWKRGCANMTYRWGTLL 276
++FA F +W T+ LE WKR A + Y W T+
Sbjct: 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411
Query: 277 MKRKFEEPRPGFHGV---LGINSITGKEEPL-YPSYKRQLRIYL-VSLPFVCLCLYFSLY 331
++++ E+ RP + + IN IT +EE + + ++ + +RI L S F + L +
Sbjct: 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470
Query: 332 VMMIYFDMEVWAL---GLHEN-SGSEWTSVLL-------YVPSIIYAIVIEIMNRLYRYA 380
+ +I + + V+ + L +N +G++ L SII I+I I+N +Y
Sbjct: 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530
Query: 381 AEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--------------- 425
A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct: 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590
Query: 426 ----------MKLLRQSLATLLITSQILNQIMESFLPYWLQ---RKHGVRVKRKVQALKA 472
+ L L ++ I N I E LP+ + R H V K+
Sbjct: 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKI----- 645
Query: 473 DIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS 532
+EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+
Sbjct: 646 ---TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701
Query: 533 DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
DA K+ F+R E + +IG WQ + +++++VVTN +I +
Sbjct: 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
>gi|218156305 anoctamin 6 isoform c [Homo sapiens]
Length = 929
Score = 172 bits (437), Expect = 7e-43
Identities = 145/525 (27%), Positives = 239/525 (45%), Gaps = 115/525 (21%)
Query: 158 LRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFALKYQPIDSIRGYF 204
+ RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+
Sbjct: 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKY--------------------- 243
GE I +YF +L Y+T L+ AV+G+ +L+ + + D
Sbjct: 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
Query: 244 ---------------------------VIFASFNLIWSTVILELWKRGCANMTYRWGTLL 276
++FA F +W T+ LE WKR A + Y W T+
Sbjct: 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411
Query: 277 MKRKFEEPRPGFHGV---LGINSITGKEEPL-YPSYKRQLRIYL-VSLPFVCLCLYFSLY 331
++++ E+ RP + + IN IT +EE + + ++ + +RI L S F + L +
Sbjct: 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470
Query: 332 VMMIYFDMEVWAL---GLHEN-SGSEWTSVLL-------YVPSIIYAIVIEIMNRLYRYA 380
+ +I + + V+ + L +N +G++ L SII I+I I+N +Y
Sbjct: 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530
Query: 381 AEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--------------- 425
A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct: 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590
Query: 426 ----------MKLLRQSLATLLITSQILNQIMESFLPYWLQ---RKHGVRVKRKVQALKA 472
+ L L ++ I N I E LP+ + R H V K+
Sbjct: 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKI----- 645
Query: 473 DIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS 532
+EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+
Sbjct: 646 ---TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701
Query: 533 DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
DA K+ F+R E + +IG WQ + +++++VVTN +I +
Sbjct: 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
>gi|218156303 anoctamin 6 isoform b [Homo sapiens]
Length = 892
Score = 172 bits (437), Expect = 7e-43
Identities = 145/525 (27%), Positives = 239/525 (45%), Gaps = 115/525 (21%)
Query: 158 LRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFALKYQPIDSIRGYF 204
+ RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+
Sbjct: 214 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 273
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKY--------------------- 243
GE I +YF +L Y+T L+ AV+G+ +L+ + + D
Sbjct: 274 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 333
Query: 244 ---------------------------VIFASFNLIWSTVILELWKRGCANMTYRWGTLL 276
++FA F +W T+ LE WKR A + Y W T+
Sbjct: 334 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 393
Query: 277 MKRKFEEPRPGFHGV---LGINSITGKEEPL-YPSYKRQLRIYL-VSLPFVCLCLYFSLY 331
++++ E+ RP + + IN IT +EE + + ++ + +RI L S F + L +
Sbjct: 394 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 452
Query: 332 VMMIYFDMEVWAL---GLHEN-SGSEWTSVLL-------YVPSIIYAIVIEIMNRLYRYA 380
+ +I + + V+ + L +N +G++ L SII I+I I+N +Y
Sbjct: 453 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 512
Query: 381 AEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--------------- 425
A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct: 513 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 572
Query: 426 ----------MKLLRQSLATLLITSQILNQIMESFLPYWLQ---RKHGVRVKRKVQALKA 472
+ L L ++ I N I E LP+ + R H V K+
Sbjct: 573 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKI----- 627
Query: 473 DIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS 532
+EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+
Sbjct: 628 ---TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 683
Query: 533 DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
DA K+ F+R E + +IG WQ + +++++VVTN +I +
Sbjct: 684 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 728
Score = 39.7 bits (91), Expect = 0.009
Identities = 14/56 (25%), Positives = 36/56 (64%)
Query: 592 ILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENL 647
+ ++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K +T+N+
Sbjct: 817 LAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 872
>gi|218156299 anoctamin 6 isoform a [Homo sapiens]
Length = 910
Score = 172 bits (437), Expect = 7e-43
Identities = 145/525 (27%), Positives = 239/525 (45%), Gaps = 115/525 (21%)
Query: 158 LRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFALKYQPIDSIRGYF 204
+ RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+
Sbjct: 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKY--------------------- 243
GE I +YF +L Y+T L+ AV+G+ +L+ + + D
Sbjct: 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
Query: 244 ---------------------------VIFASFNLIWSTVILELWKRGCANMTYRWGTLL 276
++FA F +W T+ LE WKR A + Y W T+
Sbjct: 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411
Query: 277 MKRKFEEPRPGFHGV---LGINSITGKEEPL-YPSYKRQLRIYL-VSLPFVCLCLYFSLY 331
++++ E+ RP + + IN IT +EE + + ++ + +RI L S F + L +
Sbjct: 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470
Query: 332 VMMIYFDMEVWAL---GLHEN-SGSEWTSVLL-------YVPSIIYAIVIEIMNRLYRYA 380
+ +I + + V+ + L +N +G++ L SII I+I I+N +Y
Sbjct: 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530
Query: 381 AEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--------------- 425
A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct: 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590
Query: 426 ----------MKLLRQSLATLLITSQILNQIMESFLPYWLQ---RKHGVRVKRKVQALKA 472
+ L L ++ I N I E LP+ + R H V K+
Sbjct: 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKI----- 645
Query: 473 DIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS 532
+EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+
Sbjct: 646 ---TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701
Query: 533 DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
DA K+ F+R E + +IG WQ + +++++VVTN +I +
Sbjct: 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
Score = 39.7 bits (91), Expect = 0.009
Identities = 14/56 (25%), Positives = 36/56 (64%)
Query: 592 ILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENL 647
+ ++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K +T+N+
Sbjct: 835 LAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890
>gi|145611446 tumor protein p53 inducible protein 5 [Homo sapiens]
Length = 782
Score = 157 bits (398), Expect = 2e-38
Identities = 125/495 (25%), Positives = 217/495 (43%), Gaps = 89/495 (17%)
Query: 161 LLTSGIVIQVFPLHDSEALKKLEDTWYT-RFALKYQPIDSIRGYFGETIALYFGFLEYFT 219
L+ G+ FPLH E +L+ TW R + QP+D IR YFGE +ALYF +L ++T
Sbjct: 141 LMKDGVFEARFPLHKGEG--RLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYT 198
Query: 220 FALIPMAVIGLPYYLFVWE----------------------------------------- 238
+ L+P A+ GL +L +
Sbjct: 199 YMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKL 258
Query: 239 ----DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGI 294
D D V+FA F +W+TV LE+WKR A + W + + EE + I
Sbjct: 259 THLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEM-----ALQLI 313
Query: 295 NSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSG--- 351
N K P SY R I +++L +CL + + +V+++Y V A L +S
Sbjct: 314 NCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMA-HVLVVY---RVLASALFSSSAVPF 369
Query: 352 --SEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNF 409
+ T+ ++ ++++ + I IM ++ R A L +E R S ++ ++ F
Sbjct: 370 LEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQF 429
Query: 410 LNCFASLFYIAFVL--------KDMKL-----------------LRQSLATLLITSQILN 444
F+SL YIAF+L K +L L +A ++ Q L+
Sbjct: 430 FTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLS 489
Query: 445 QIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQ 504
+E +P+ + +R L D + + + L + T+ FD+++E+ +Q
Sbjct: 490 NCVEYLVPWVTHKCRSLRASESGH-LPRDPELRDWRRNYLLNPVNTF-SLFDEFMEMMIQ 547
Query: 505 FGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSV 564
+G+ ++F +PLA A+ +N E+ DA+KM + +R + +IG W ET+ V
Sbjct: 548 YGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGV 607
Query: 565 ISVVTNCALIGMSPQ 579
++V+ N +I + +
Sbjct: 608 LAVIANGMVIAFTSE 622
Score = 32.3 bits (72), Expect = 1.4
Identities = 12/41 (29%), Positives = 25/41 (60%)
Query: 592 ILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESL 632
+ V+ EH L +K I A+ +PD P+ ++ K+ ++++ L
Sbjct: 703 LAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRL 743
>gi|218081589 anoctamin 5 isoform b [Homo sapiens]
Length = 912
Score = 153 bits (386), Expect = 6e-37
Identities = 138/531 (25%), Positives = 218/531 (41%), Gaps = 120/531 (22%)
Query: 158 LRRLLTSGIVIQVFPLHDSEALKK------------LEDTWYTRFALKY--QPIDSIRGY 203
+ RLL S +PLHD + K L W RF+ Y QP+D I+ Y
Sbjct: 236 IERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNW-ARFSYFYKEQPLDLIKNY 294
Query: 204 FGETIALYFGFLEYFTFALIPMAVIGLPYYLF---------------------------- 235
+GE I +YF FL ++T L AV+GL +++
Sbjct: 295 YGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPL 354
Query: 236 ------VWE--------------DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTL 275
W D + V FA F IW T+ LE WK+ A + Y W +
Sbjct: 355 CDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLV 414
Query: 276 LMKRKFEEP--RPGFHGVLG---INSITGKEEPLYPSYKRQLRIYLVSLPFVCL--CLYF 328
+ + ++ RP F + +N++T + EP P Y R + Y +S V L L
Sbjct: 415 DFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTR-IPWYFLSGATVTLWMSLVV 473
Query: 329 SLYVMMIYFDMEVWAL--GLHENSGSEWTSVLLYVPSIIYA--------IVIEIMNRLYR 378
+ V +I + + V+A E+ S P I + IVI I+N Y
Sbjct: 474 TSMVAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYE 533
Query: 379 YAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAF--------------VLK 424
+ ++T E R Y++ L LK+ +F F+N ++S FY+AF +
Sbjct: 534 KISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFN 593
Query: 425 DMKL-----------LRQSLATLLITSQILNQIMESFLP----YWLQRKHGVRVKRKVQA 469
+ + L L ++ QI I E+ P +W +RK ++
Sbjct: 594 EWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEKLYSR 653
Query: 470 LKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTE 529
+ D D + LG F +YLE QFG+V+LF +PLA A++NN E
Sbjct: 654 WEQDHDLESFGP----------LGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVE 703
Query: 530 VNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQV 580
+ DA K+ ++R + + +IGVWQ M+V+SV TN ++ + +
Sbjct: 704 IRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDI 754
Score = 38.9 bits (89), Expect = 0.015
Identities = 18/67 (26%), Positives = 37/67 (55%)
Query: 581 NAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQM 640
N F A + ++ +EH + +KF+LA+ IPD P+ + ++ R + +++ L ++
Sbjct: 821 NMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFEL 880
Query: 641 KLVTENL 647
+ ENL
Sbjct: 881 NKLKENL 887
>gi|47106048 anoctamin 5 isoform a [Homo sapiens]
Length = 913
Score = 153 bits (386), Expect = 6e-37
Identities = 138/531 (25%), Positives = 218/531 (41%), Gaps = 120/531 (22%)
Query: 158 LRRLLTSGIVIQVFPLHDSEALKK------------LEDTWYTRFALKY--QPIDSIRGY 203
+ RLL S +PLHD + K L W RF+ Y QP+D I+ Y
Sbjct: 237 IERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNW-ARFSYFYKEQPLDLIKNY 295
Query: 204 FGETIALYFGFLEYFTFALIPMAVIGLPYYLF---------------------------- 235
+GE I +YF FL ++T L AV+GL +++
Sbjct: 296 YGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPL 355
Query: 236 ------VWE--------------DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTL 275
W D + V FA F IW T+ LE WK+ A + Y W +
Sbjct: 356 CDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLV 415
Query: 276 LMKRKFEEP--RPGFHGVLG---INSITGKEEPLYPSYKRQLRIYLVSLPFVCL--CLYF 328
+ + ++ RP F + +N++T + EP P Y R + Y +S V L L
Sbjct: 416 DFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTR-IPWYFLSGATVTLWMSLVV 474
Query: 329 SLYVMMIYFDMEVWAL--GLHENSGSEWTSVLLYVPSIIYA--------IVIEIMNRLYR 378
+ V +I + + V+A E+ S P I + IVI I+N Y
Sbjct: 475 TSMVAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYE 534
Query: 379 YAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAF--------------VLK 424
+ ++T E R Y++ L LK+ +F F+N ++S FY+AF +
Sbjct: 535 KISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFN 594
Query: 425 DMKL-----------LRQSLATLLITSQILNQIMESFLP----YWLQRKHGVRVKRKVQA 469
+ + L L ++ QI I E+ P +W +RK ++
Sbjct: 595 EWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEKLYSR 654
Query: 470 LKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTE 529
+ D D + LG F +YLE QFG+V+LF +PLA A++NN E
Sbjct: 655 WEQDHDLESFGP----------LGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVE 704
Query: 530 VNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQV 580
+ DA K+ ++R + + +IGVWQ M+V+SV TN ++ + +
Sbjct: 705 IRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDI 755
Score = 38.9 bits (89), Expect = 0.015
Identities = 18/67 (26%), Positives = 37/67 (55%)
Query: 581 NAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQM 640
N F A + ++ +EH + +KF+LA+ IPD P+ + ++ R + +++ L ++
Sbjct: 822 NMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFEL 881
Query: 641 KLVTENL 647
+ ENL
Sbjct: 882 NKLKENL 888
>gi|209862785 anoctamin 2 [Homo sapiens]
Length = 998
Score = 139 bits (350), Expect = 8e-33
Identities = 132/529 (24%), Positives = 219/529 (41%), Gaps = 112/529 (21%)
Query: 158 LRRLLTSGIVIQVFPLHDSEA---------LKKLEDTWYTRFAL--KYQPIDSIRGYFGE 206
+ L+ + I +PLHD E K L W R+ + K+QPID IR YFGE
Sbjct: 295 INSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEW-ARYGVFYKFQPIDLIRKYFGE 353
Query: 207 TIALYFGFLEYFTFALIPMAVIGLPYYLF------------------------------- 235
I LYF +L +T LIP +VIG+ +L+
Sbjct: 354 KIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSC 413
Query: 236 -VWE--------------DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMK-- 278
W D V F+ F +W+T+ LE WKR + Y W ++
Sbjct: 414 DYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEE 473
Query: 279 --RKFEEPRPGFHGVLGINSITGKEEPLYP------------------SYKRQLRIYLV- 317
R E RP + + + + ++K + YL+
Sbjct: 474 EERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMN 533
Query: 318 --SLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNR 375
S+ F+ + ++ +++Y AL L++ + S + II +VI I++
Sbjct: 534 FASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDE 593
Query: 376 LYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD---------- 425
+Y A++LT E + E ++ LILK + F+N ++ +FY+AF
Sbjct: 594 IYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVY 653
Query: 426 ----------------MKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQA 469
M+L Q +L I N I E +P +K ++K + +A
Sbjct: 654 VFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKL--KKLFRKLKDETEA 711
Query: 470 LKADIDATLY-EQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFT 528
+ D + + EQ L+ + Y G +Y+E+ +QFG+V+LF +PLA FA+LNN
Sbjct: 712 GETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVI 771
Query: 529 EVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
EV DA K +RP + + +IG+W + SV++N +I ++
Sbjct: 772 EVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAIT 820
>gi|194306539 anoctamin 1, calcium activated chloride channel [Homo
sapiens]
Length = 986
Score = 129 bits (323), Expect = 1e-29
Identities = 124/543 (22%), Positives = 228/543 (41%), Gaps = 131/543 (24%)
Query: 161 LLTSGIVIQVFPLHDSEA---------LKKLEDTWYTRFAL--KYQPIDSIRGYFGETIA 209
LL +G+ +PLHD + K L + W R+ + KYQPID +R YFGE I
Sbjct: 271 LLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEW-ARYGVFYKYQPIDLVRKYFGEKIG 329
Query: 210 LYFGFLEYFTFALIPMAVIGLPYYLF--------------------------------VW 237
LYF +L +T LIP +++G+ +L+ W
Sbjct: 330 LYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYW 389
Query: 238 E--------------DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFE- 282
+ D V F+ F +W+ +E WKR + YRW + + E
Sbjct: 390 KMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEA 449
Query: 283 ---EPRPGFHGVLGINSIT----GKEE----PLYPSYKRQLRIY---------------- 315
PR + + S+ KE+ P + K + R+
Sbjct: 450 VKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTW 509
Query: 316 ----------LVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPS-- 363
LVS+ F+ + + F++ + +I + + + A +S S +++ + V +
Sbjct: 510 RDRFPAYLTNLVSIIFM-IAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATA 568
Query: 364 -IIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAF- 421
II +VI +++ +Y A +LT E + E +++ LI K + F+N + +FY+AF
Sbjct: 569 VIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFF 628
Query: 422 -------------VLKDMKL-----------LRQSLATLLITSQIL-NQIMESFLPYWLQ 456
+ + ++ L L+ +++ Q++ N + E +P +
Sbjct: 629 KGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIP---K 685
Query: 457 RKHGVRVKRKVQALKADIDATLYEQVILEKE--MGTYLGTFDDYLELFLQFGYVSLFSCV 514
K +R + Q D + + + E + + + G +Y+E+ +QFG+V+LF
Sbjct: 686 MKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVAS 745
Query: 515 YPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALI 574
+PLA FA+LNN E+ DA K +RP + + +IG+W + ++V+ N +I
Sbjct: 746 FPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVI 805
Query: 575 GMS 577
+
Sbjct: 806 SFT 808
>gi|169161033 PREDICTED: hypothetical protein [Homo sapiens]
Length = 723
Score = 37.7 bits (86), Expect = 0.034
Identities = 17/44 (38%), Positives = 27/44 (61%)
Query: 503 LQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFS 546
LQFG++++F + LA F +LNN E+ DA K ++RP +
Sbjct: 508 LQFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCKYQRPMA 551
>gi|239747244 PREDICTED: hypothetical protein [Homo sapiens]
Length = 719
Score = 37.7 bits (86), Expect = 0.034
Identities = 17/44 (38%), Positives = 27/44 (61%)
Query: 503 LQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFS 546
LQFG++++F + LA F +LNN E+ DA K ++RP +
Sbjct: 504 LQFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCKYQRPMA 547
>gi|239741065 PREDICTED: hypothetical protein [Homo sapiens]
Length = 494
Score = 37.7 bits (86), Expect = 0.034
Identities = 17/44 (38%), Positives = 27/44 (61%)
Query: 503 LQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFS 546
LQFG++++F + LA F +LNN E+ DA K ++RP +
Sbjct: 279 LQFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCKYQRPMA 322
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 31.6 bits (70), Expect = 2.4
Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 18/122 (14%)
Query: 97 MRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKS 156
+R F+ T ++F G + + E Q +I+ E ++K M P + L+ +S
Sbjct: 124 LRRFSVTTMRDF-GMGKRSVEERIQEEAQCLIE---ELRKSKGALMDPTF----LF--QS 173
Query: 157 LLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLE 216
+ ++ S + + F D E LK L L YQ I FG+ L+ GFL+
Sbjct: 174 ITANIICSIVFGKRFHYQDQEFLKMLN--------LFYQTFSLISSVFGQLFELFSGFLK 225
Query: 217 YF 218
YF
Sbjct: 226 YF 227
>gi|24497620 signal recognition particle 68kDa [Homo sapiens]
Length = 627
Score = 30.8 bits (68), Expect = 4.2
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 403 KVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVR 462
KV +L+ + + ++ +K + + + L L+ Q + S P L R + +
Sbjct: 372 KVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDII 431
Query: 463 VKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFA 522
++ V+ L+ L E +KE+G F Y F+ YV + L
Sbjct: 432 LQNLVELLQLP---GLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDR 488
Query: 523 VLNNFTEVNSDA 534
VL EVNSDA
Sbjct: 489 VLKYANEVNSDA 500
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 30.0 bits (66), Expect = 7.1
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 9/95 (9%)
Query: 154 GKSLLRRLLTSGIVIQVFPLHDS------EALKKLEDTWYTRFALKYQPID---SIRGYF 204
GK L R+L +S H + +A K E+TW A K Q S+ +
Sbjct: 851 GKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDY 910
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWED 239
+ I L+ FL F F ++ + Y+L +W D
Sbjct: 911 MKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD 945
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 30.0 bits (66), Expect = 7.1
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 9/95 (9%)
Query: 154 GKSLLRRLLTSGIVIQVFPLHDS------EALKKLEDTWYTRFALKYQPID---SIRGYF 204
GK L R+L +S H + +A K E+TW A K Q S+ +
Sbjct: 792 GKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDY 851
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWED 239
+ I L+ FL F F ++ + Y+L +W D
Sbjct: 852 MKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD 886
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 30.0 bits (66), Expect = 7.1
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 9/95 (9%)
Query: 154 GKSLLRRLLTSGIVIQVFPLHDS------EALKKLEDTWYTRFALKYQPID---SIRGYF 204
GK L R+L +S H + +A K E+TW A K Q S+ +
Sbjct: 848 GKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDY 907
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWED 239
+ I L+ FL F F ++ + Y+L +W D
Sbjct: 908 MKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD 942
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 30.0 bits (66), Expect = 7.1
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 9/95 (9%)
Query: 154 GKSLLRRLLTSGIVIQVFPLHDS------EALKKLEDTWYTRFALKYQPID---SIRGYF 204
GK L R+L +S H + +A K E+TW A K Q S+ +
Sbjct: 907 GKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDY 966
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWED 239
+ I L+ FL F F ++ + Y+L +W D
Sbjct: 967 MKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD 1001
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 30.0 bits (66), Expect = 7.1
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 9/95 (9%)
Query: 154 GKSLLRRLLTSGIVIQVFPLHDS------EALKKLEDTWYTRFALKYQPID---SIRGYF 204
GK L R+L +S H + +A K E+TW A K Q S+ +
Sbjct: 907 GKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDY 966
Query: 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWED 239
+ I L+ FL F F ++ + Y+L +W D
Sbjct: 967 MKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD 1001
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 30.0 bits (66), Expect = 7.1
Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 12/103 (11%)
Query: 109 KGFDDNNDDFLTMAECQFIIKHELENL--RAKDEKMIPGYPQAKLYPGKSLLRRLLTSGI 166
K F+D N +F+ + + I+K LEN + K E + +AK+ +R++ S
Sbjct: 875 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNA 934
Query: 167 VI---------QVFPLH-DSEALKKLEDTWYTRFALKYQPIDS 199
I ++ LH + +A KK DT +KY PI S
Sbjct: 935 EILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 977
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 30.0 bits (66), Expect = 7.1
Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 12/103 (11%)
Query: 109 KGFDDNNDDFLTMAECQFIIKHELENL--RAKDEKMIPGYPQAKLYPGKSLLRRLLTSGI 166
K F+D N +F+ + + I+K LEN + K E + +AK+ +R++ S
Sbjct: 888 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNA 947
Query: 167 VI---------QVFPLH-DSEALKKLEDTWYTRFALKYQPIDS 199
I ++ LH + +A KK DT +KY PI S
Sbjct: 948 EILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,266,584
Number of Sequences: 37866
Number of extensions: 931219
Number of successful extensions: 3013
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2928
Number of HSP's gapped (non-prelim): 59
length of query: 660
length of database: 18,247,518
effective HSP length: 109
effective length of query: 551
effective length of database: 14,120,124
effective search space: 7780188324
effective search space used: 7780188324
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.