Search of human proteins with 91982767

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
         (1151 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                   2448   0.0  
gi|147904700 semaphorin 5A [Homo sapiens]                            1367   0.0  
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          308   1e-83
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          308   1e-83
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          308   1e-83
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          308   1e-83
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          308   1e-83
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   289   9e-78
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    289   1e-77
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     286   6e-77
gi|16306552 semaphorin Y [Homo sapiens]                               283   9e-76
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          276   8e-74
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]           276   8e-74
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]          272   1e-72
gi|157388902 semaphorin 4C [Homo sapiens]                             270   4e-72
gi|118572606 hemicentin 1 [Homo sapiens]                              268   3e-71
gi|21361914 semaphorin B [Homo sapiens]                               267   5e-71
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   261   2e-69
gi|188497703 semaphorin 3F [Homo sapiens]                             261   4e-69
gi|39777610 semaphorin 4B precursor [Homo sapiens]                    253   6e-67
gi|39777608 semaphorin 4B precursor [Homo sapiens]                    253   6e-67
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   253   1e-66
gi|5454048 semaphorin 3C [Homo sapiens]                               252   1e-66
gi|6912650 semaphorin 3E [Homo sapiens]                               251   4e-66
gi|41406086 semaphorin 3D [Homo sapiens]                              249   1e-65
gi|19923279 semaphorin W [Homo sapiens]                               216   8e-56
gi|9910362 semaphorin sem2 [Homo sapiens]                             208   2e-53
gi|28872814 semaphorin 4G [Homo sapiens]                              201   3e-51
gi|4505737 complement factor properdin precursor [Homo sapiens]       176   1e-43
gi|223671861 complement factor properdin precursor [Homo sapiens]     176   1e-43

>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score = 2448 bits (6344), Expect = 0.0
 Identities = 1151/1151 (100%), Positives = 1151/1151 (100%)

Query: 1    MPCGFSPSPVAHHLVPGPPDTPAQQLRCGWTVGGWLLSLVRGLLPCLPPGARTAEGPIMV 60
            MPCGFSPSPVAHHLVPGPPDTPAQQLRCGWTVGGWLLSLVRGLLPCLPPGARTAEGPIMV
Sbjct: 1    MPCGFSPSPVAHHLVPGPPDTPAQQLRCGWTVGGWLLSLVRGLLPCLPPGARTAEGPIMV 60

Query: 61   LAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTY 120
            LAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTY
Sbjct: 61   LAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTY 120

Query: 121  PGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEE 180
            PGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEE
Sbjct: 121  PGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEE 180

Query: 181  ECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAV 240
            ECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAV
Sbjct: 181  ECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAV 240

Query: 241  ISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFF 300
            ISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFF
Sbjct: 241  ISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFF 300

Query: 301  LRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQ 360
            LRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQ
Sbjct: 301  LRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQ 360

Query: 361  SAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPI 420
            SAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPI
Sbjct: 361  SAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPI 420

Query: 421  PNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQ 480
            PNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQ
Sbjct: 421  PNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQ 480

Query: 481  AKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARAL 540
            AKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARAL
Sbjct: 481  AKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARAL 540

Query: 541  FVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITA 600
            FVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITA
Sbjct: 541  FVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITA 600

Query: 601  CPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIAN 660
            CPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIAN
Sbjct: 601  CPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIAN 660

Query: 661  CSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCP 720
            CSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCP
Sbjct: 661  CSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCP 720

Query: 721  VPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWT 780
            VPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWT
Sbjct: 721  VPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWT 780

Query: 781  PWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEV 840
            PWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEV
Sbjct: 781  PWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEV 840

Query: 841  LLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQ 900
            LLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQ
Sbjct: 841  LLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQ 900

Query: 901  DCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCA 960
            DCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCA
Sbjct: 901  DCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCA 960

Query: 961  TQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPA 1020
            TQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPA
Sbjct: 961  TQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPA 1020

Query: 1021 SSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHL 1080
            SSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHL
Sbjct: 1021 SSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHL 1080

Query: 1081 HYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPE 1140
            HYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPE
Sbjct: 1081 HYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPE 1140

Query: 1141 ASPGQRCFPNS 1151
            ASPGQRCFPNS
Sbjct: 1141 ASPGQRCFPNS 1151


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score = 1367 bits (3539), Expect = 0.0
 Identities = 616/1043 (59%), Positives = 780/1043 (74%), Gaps = 6/1043 (0%)

Query: 98   CALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLL 157
            C  ++HP ++++++ PW+  F    A DFSQL  DP   +L+VGARNYLFRL L ++SL+
Sbjct: 30   CQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI 89

Query: 158  QATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLS 217
            QA EW   E T+++C SKGK++EECQNY+RVL+V G ++F CGTNAF+P+CT+R + NL+
Sbjct: 90   QAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLT 149

Query: 218  RTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQY 277
               ++I+G+ARCPY P+HNSTA++++ GELYAAT +DF GRDPAIYRSLG  PPLRTAQY
Sbjct: 150  EIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209

Query: 278  NSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWT 337
            NSKWLNEPNFV++YDIG F YFF RENAVEHDCG+TV+SR ARVCKND+GGRFLLEDTWT
Sbjct: 210  NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWT 269

Query: 338  TFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQ 397
            TFMKARLNCSRPGEVPFYYNELQS F LPE DLIYG+FTTNVNSIAASAVC FNLSAI+Q
Sbjct: 270  TFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQ 329

Query: 398  AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQP 457
            AF+GPF+YQEN R+AWLP  NP P+FQCGT+ + G   NLTER+LQDAQ+  LM E VQP
Sbjct: 330  AFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQ-GLYVNLTERNLQDAQKFILMHEVVQP 388

Query: 458  VTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEEL 517
            VT  P   +D+ RFSH+ VD+VQ ++ L H++Y+ T+ GTI K     +++   C LEE+
Sbjct: 389  VTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEI 448

Query: 518  HVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDG 577
             + P  RREP+RSL+ILHS   LFVGLR+ V+++PL+RC  YR++  C+GA+DPYCGWD 
Sbjct: 449  ELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDV 508

Query: 578  KQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRAR 637
              ++C++LE+S +M+ W Q+I+ACP RN+T DG FG WSPW PC H DG   GSCLCR R
Sbjct: 509  VMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTR 568

Query: 638  SCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPR 697
            SCDSP P+CGG  C GP + IANCSRNG WTPW+SW+ CST+CGIGFQVRQRSCSNP PR
Sbjct: 569  SCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPR 628

Query: 698  HGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLG 757
            HGGR+CVG++REER+CNE+  CP  +FW  WG W +C++ CGGG+Q+RRR CENG  C G
Sbjct: 629  HGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAG 688

Query: 758  CGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRR 817
            C VE+++CN   CPE+++ TPWTPW PVN++  G   EQRFR+TC+A LADP+ L+ GR+
Sbjct: 689  CNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQ 748

Query: 818  RTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRK 877
            R E R C +DG+  C TD L    LR+G  S HTV+G W+AW  WS CSRDC  G R RK
Sbjct: 749  RIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRK 808

Query: 878  RTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSC 937
            R C NPEP+ GG+PC+G + EYQ+CN   CPV G WSCW+ W+ CSA+CGGGHY RTRSC
Sbjct: 809  RVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSC 868

Query: 938  TSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSS 997
            ++PAP+ G DICLGLHTEEALC TQ CPE WS WS+WS+C   G Q R+R C  L P  S
Sbjct: 869  SNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPMGS 928

Query: 998  ACAGNSSQSRPCPYSE--IP-VILPASSMEEATDCAGFNLIHLVATGISCFLGSGLLTLA 1054
             C+GN+++SRPC +    IP V +  SS  E   C  FN+ H++A G+S  +   LLTL 
Sbjct: 929  QCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLL 988

Query: 1055 VYLSCQHCQRQSQESTLVHPATPNHLHYK-GGGTPKNEKYTPME-FKTLNKNNLIPDDRA 1112
            VY  CQ  Q+QS ++T++HP +P  L+        K +KY  +E  K  NKNNLI ++R 
Sbjct: 989  VYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERN 1048

Query: 1113 NFYPLQQTNVYTTTYYPSPLNKH 1135
             ++    T    +  Y + LN +
Sbjct: 1049 KYFNPHLTGKTYSNAYFTDLNNY 1071


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  308 bits (790), Expect = 1e-83
 Identities = 191/525 (36%), Positives = 297/525 (56%), Gaps = 47/525 (8%)

Query: 97  LCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGN--------QLIVGARNYLF- 147
           L  +S+   V+F +    ++   Y  +R +      PSGN        QL++  R+ L+ 
Sbjct: 12  LLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYI 71

Query: 148 ----RLSLANVSLLQATE--------WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRK 195
               ++   N++ +  TE        W S +  R +C  KGK ++EC N+++V +    +
Sbjct: 72  AGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131

Query: 196 -VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVID 254
            VF+CGTNAF+PMC   ++  L    E+I+G+ARCP+D R  + A+ +  G+LY+ATV D
Sbjct: 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVAD 190

Query: 255 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRT 313
           F   D  IYRS+G G  LRT +Y+SKW+ EP+F+ A + G + YFF RE AVEH + G+ 
Sbjct: 191 FLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKA 250

Query: 314 VYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD--- 369
           VYSRVAR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + + +   
Sbjct: 251 VYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

Query: 370 LIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTL 428
            + GVFTT +NSI  SAVCAF++  I + F G F+ Q+ P + W  +  + +P  + G  
Sbjct: 311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCC 370

Query: 429 PETGPNE------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVDLVQ 480
            + G  E      +  + +L   +   LM  AV P+  EP  T+  VR+  + + VD   
Sbjct: 371 AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430

Query: 481 AKDTLYHVLYIGTESGTILKALS-TASRSLH-GCYLEELHVLPPGR-------REPLRSL 531
                Y V+++G+E+G +LK L+ T+  SL+    LEE+      +        + + SL
Sbjct: 431 GPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISL 490

Query: 532 RILHSARALFVGLRDGVLRVPLERCAAYRS-QGACLGARDPYCGW 575
           ++     AL+V     ++R+PL RC  Y S + +C+ +RDPYCGW
Sbjct: 491 QLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  308 bits (790), Expect = 1e-83
 Identities = 191/525 (36%), Positives = 297/525 (56%), Gaps = 47/525 (8%)

Query: 97  LCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGN--------QLIVGARNYLF- 147
           L  +S+   V+F +    ++   Y  +R +      PSGN        QL++  R+ L+ 
Sbjct: 12  LLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYI 71

Query: 148 ----RLSLANVSLLQATE--------WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRK 195
               ++   N++ +  TE        W S +  R +C  KGK ++EC N+++V +    +
Sbjct: 72  AGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131

Query: 196 -VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVID 254
            VF+CGTNAF+PMC   ++  L    E+I+G+ARCP+D R  + A+ +  G+LY+ATV D
Sbjct: 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVAD 190

Query: 255 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRT 313
           F   D  IYRS+G G  LRT +Y+SKW+ EP+F+ A + G + YFF RE AVEH + G+ 
Sbjct: 191 FLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKA 250

Query: 314 VYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD--- 369
           VYSRVAR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + + +   
Sbjct: 251 VYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

Query: 370 LIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTL 428
            + GVFTT +NSI  SAVCAF++  I + F G F+ Q+ P + W  +  + +P  + G  
Sbjct: 311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCC 370

Query: 429 PETGPNE------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVDLVQ 480
            + G  E      +  + +L   +   LM  AV P+  EP  T+  VR+  + + VD   
Sbjct: 371 AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430

Query: 481 AKDTLYHVLYIGTESGTILKALS-TASRSLH-GCYLEELHVLPPGR-------REPLRSL 531
                Y V+++G+E+G +LK L+ T+  SL+    LEE+      +        + + SL
Sbjct: 431 GPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISL 490

Query: 532 RILHSARALFVGLRDGVLRVPLERCAAYRS-QGACLGARDPYCGW 575
           ++     AL+V     ++R+PL RC  Y S + +C+ +RDPYCGW
Sbjct: 491 QLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  308 bits (790), Expect = 1e-83
 Identities = 191/525 (36%), Positives = 297/525 (56%), Gaps = 47/525 (8%)

Query: 97  LCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGN--------QLIVGARNYLF- 147
           L  +S+   V+F +    ++   Y  +R +      PSGN        QL++  R+ L+ 
Sbjct: 12  LLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYI 71

Query: 148 ----RLSLANVSLLQATE--------WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRK 195
               ++   N++ +  TE        W S +  R +C  KGK ++EC N+++V +    +
Sbjct: 72  AGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131

Query: 196 -VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVID 254
            VF+CGTNAF+PMC   ++  L    E+I+G+ARCP+D R  + A+ +  G+LY+ATV D
Sbjct: 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVAD 190

Query: 255 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRT 313
           F   D  IYRS+G G  LRT +Y+SKW+ EP+F+ A + G + YFF RE AVEH + G+ 
Sbjct: 191 FLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKA 250

Query: 314 VYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD--- 369
           VYSRVAR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + + +   
Sbjct: 251 VYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

Query: 370 LIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTL 428
            + GVFTT +NSI  SAVCAF++  I + F G F+ Q+ P + W  +  + +P  + G  
Sbjct: 311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCC 370

Query: 429 PETGPNE------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVDLVQ 480
            + G  E      +  + +L   +   LM  AV P+  EP  T+  VR+  + + VD   
Sbjct: 371 AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430

Query: 481 AKDTLYHVLYIGTESGTILKALS-TASRSLH-GCYLEELHVLPPGR-------REPLRSL 531
                Y V+++G+E+G +LK L+ T+  SL+    LEE+      +        + + SL
Sbjct: 431 GPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISL 490

Query: 532 RILHSARALFVGLRDGVLRVPLERCAAYRS-QGACLGARDPYCGW 575
           ++     AL+V     ++R+PL RC  Y S + +C+ +RDPYCGW
Sbjct: 491 QLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  308 bits (790), Expect = 1e-83
 Identities = 191/525 (36%), Positives = 297/525 (56%), Gaps = 47/525 (8%)

Query: 97  LCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGN--------QLIVGARNYLF- 147
           L  +S+   V+F +    ++   Y  +R +      PSGN        QL++  R+ L+ 
Sbjct: 12  LLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYI 71

Query: 148 ----RLSLANVSLLQATE--------WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRK 195
               ++   N++ +  TE        W S +  R +C  KGK ++EC N+++V +    +
Sbjct: 72  AGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131

Query: 196 -VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVID 254
            VF+CGTNAF+PMC   ++  L    E+I+G+ARCP+D R  + A+ +  G+LY+ATV D
Sbjct: 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVAD 190

Query: 255 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRT 313
           F   D  IYRS+G G  LRT +Y+SKW+ EP+F+ A + G + YFF RE AVEH + G+ 
Sbjct: 191 FLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKA 250

Query: 314 VYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD--- 369
           VYSRVAR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + + +   
Sbjct: 251 VYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

Query: 370 LIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTL 428
            + GVFTT +NSI  SAVCAF++  I + F G F+ Q+ P + W  +  + +P  + G  
Sbjct: 311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCC 370

Query: 429 PETGPNE------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVDLVQ 480
            + G  E      +  + +L   +   LM  AV P+  EP  T+  VR+  + + VD   
Sbjct: 371 AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430

Query: 481 AKDTLYHVLYIGTESGTILKALS-TASRSLH-GCYLEELHVLPPGR-------REPLRSL 531
                Y V+++G+E+G +LK L+ T+  SL+    LEE+      +        + + SL
Sbjct: 431 GPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISL 490

Query: 532 RILHSARALFVGLRDGVLRVPLERCAAYRS-QGACLGARDPYCGW 575
           ++     AL+V     ++R+PL RC  Y S + +C+ +RDPYCGW
Sbjct: 491 QLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  308 bits (790), Expect = 1e-83
 Identities = 191/525 (36%), Positives = 297/525 (56%), Gaps = 47/525 (8%)

Query: 97  LCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGN--------QLIVGARNYLF- 147
           L  +S+   V+F +    ++   Y  +R +      PSGN        QL++  R+ L+ 
Sbjct: 12  LLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYI 71

Query: 148 ----RLSLANVSLLQATE--------WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRK 195
               ++   N++ +  TE        W S +  R +C  KGK ++EC N+++V +    +
Sbjct: 72  AGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131

Query: 196 -VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVID 254
            VF+CGTNAF+PMC   ++  L    E+I+G+ARCP+D R  + A+ +  G+LY+ATV D
Sbjct: 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVAD 190

Query: 255 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRT 313
           F   D  IYRS+G G  LRT +Y+SKW+ EP+F+ A + G + YFF RE AVEH + G+ 
Sbjct: 191 FLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKA 250

Query: 314 VYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD--- 369
           VYSRVAR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + + +   
Sbjct: 251 VYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

Query: 370 LIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTL 428
            + GVFTT +NSI  SAVCAF++  I + F G F+ Q+ P + W  +  + +P  + G  
Sbjct: 311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCC 370

Query: 429 PETGPNE------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVDLVQ 480
            + G  E      +  + +L   +   LM  AV P+  EP  T+  VR+  + + VD   
Sbjct: 371 AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430

Query: 481 AKDTLYHVLYIGTESGTILKALS-TASRSLH-GCYLEELHVLPPGR-------REPLRSL 531
                Y V+++G+E+G +LK L+ T+  SL+    LEE+      +        + + SL
Sbjct: 431 GPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISL 490

Query: 532 RILHSARALFVGLRDGVLRVPLERCAAYRS-QGACLGARDPYCGW 575
           ++     AL+V     ++R+PL RC  Y S + +C+ +RDPYCGW
Sbjct: 491 QLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW 535


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  289 bits (740), Expect = 9e-78
 Identities = 169/486 (34%), Positives = 274/486 (56%), Gaps = 32/486 (6%)

Query: 138 LIVGARNYLFRLSL-----ANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVA 192
           L + AR++++ + +       +   +   W S +    +C+ KGK ++EC N+++VL+  
Sbjct: 68  LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKK 127

Query: 193 GRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAAT 251
               +F+CGTNAF+P C + ++  L    ++ +G+ARCPYD +H + A+ +  G+LY+AT
Sbjct: 128 NDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFAD-GKLYSAT 186

Query: 252 VIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEHD-C 310
           V DF   D  IYRSLG  P LRT +++SKWL EP FV A D G + YFF RE AVE++  
Sbjct: 187 VTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTM 246

Query: 311 GRTVYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQS---AFHLP 366
           G+ V+ RVA+VCKND+GG + +LE  WT+F+KARLNCS PG+  FY+N LQ+      + 
Sbjct: 247 GKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRIN 306

Query: 367 EQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIAN---PIPNF 423
            +D++   F+T  NSI  SAVCA+++  I+  F G F+ Q++P + W P+ +   P P  
Sbjct: 307 GRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRP 366

Query: 424 QC----GTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVD 477
            C     +L     +    + +L   +   LM EAV  +   P   +  VR+  + + VD
Sbjct: 367 GCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVD 426

Query: 478 LVQAKDTLYHVLYIGTESGTILKALSTASRS---LHGCYLEELHVLPPGR-------REP 527
                   + V+++G+E G ILK L+    S       +LEE+ V    +        + 
Sbjct: 427 TAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKR 486

Query: 528 LRSLRILHSARALFVGLRDGVLRVPLERCAAY-RSQGACLGARDPYCGWDGKQQRCSTLE 586
           +  +++  ++ +L+V     V++VPL RC  + + +  C+ +RDPYCGW  +   CS L 
Sbjct: 487 IMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLS 546

Query: 587 DSSNMS 592
            +S ++
Sbjct: 547 PNSRLT 552


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  289 bits (739), Expect = 1e-77
 Identities = 182/487 (37%), Positives = 264/487 (54%), Gaps = 34/487 (6%)

Query: 122 GARDFSQLALDPSGNQLIVGARNYLFRLSL-----ANVSLLQATEWASSEDTRRSCQSKG 176
           GA D +   +      L +G R+ L+R+ L       +   +   W S+      C+ KG
Sbjct: 61  GADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKG 120

Query: 177 KTEEECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRH 235
           K E EC+N+V+VL++     +F+CG+NAF+P+C +  +  L    + I+G+ARCPYDP+H
Sbjct: 121 KQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKH 180

Query: 236 NSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGL 295
            + A+ S  G L+ ATV DF   D  IYRSLG  P LRT +++SKW  EP FV A + G 
Sbjct: 181 ANVALFSD-GMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGS 239

Query: 296 FAYFFLRENAVEHD-CGRTVYSRVARVCKNDVGGR-FLLEDTWTTFMKARLNCSRPGEVP 353
             YFF RE A+E +   + V SRVARVCKNDVGG   +LE  WT+F+KARLNCS PG+  
Sbjct: 240 HVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSH 299

Query: 354 FYYNELQS---AFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPR 410
           FY+N LQ+      L  + ++  VF+T  NSI  SAVCAF+L+ ++  F G FR Q++P 
Sbjct: 300 FYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPE 359

Query: 411 AAWLPIAN---PIPNFQCGTLP--ETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVT 465
           + W P+     P P   C   P  +   +  L +  L   +   LM EAV  +   P + 
Sbjct: 360 SIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWIL 419

Query: 466 QDSVR--FSHLVVDLVQAKDTLYHVLYIGTESGTILKAL-----STASRSLHGCYLEELH 518
           +  +R   + + VD+         V+++G+E+GT+LK L     ST+  S    +LEE  
Sbjct: 420 RTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLEEFE 479

Query: 519 VLPPGR---------REPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRS-QGACLGA 568
              P R          + L SL +  ++  L       V+RVP+ RC  Y      C+G+
Sbjct: 480 TYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGS 539

Query: 569 RDPYCGW 575
           +DPYCGW
Sbjct: 540 QDPYCGW 546


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  286 bits (733), Expect = 6e-77
 Identities = 174/483 (36%), Positives = 269/483 (55%), Gaps = 41/483 (8%)

Query: 131 LDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTE-EECQNYVRVL 189
           LD   ++L VGA++++F   L N+   Q   W  S   R  C+  GK   +EC N+++VL
Sbjct: 62  LDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVL 121

Query: 190 IVAGRK-VFMCGTNAFSPMCTSRQVGNLSR-TIEKI------NGVARCPYDPRHNSTAVI 241
               +  ++ CGT AF P+CT  ++G+     I K+      NG  + PYDP+   TA +
Sbjct: 122 KAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKL-LTASL 180

Query: 242 SSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLF----- 296
              GELY+ T  DF GRD AI+R+LG   P+RT Q++S+WLN+P F++A+ I        
Sbjct: 181 LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED 240

Query: 297 --AYFFLRENAVEHD-CGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGE-- 351
              YFF RENA++ +  G+  ++R+ ++CKND GG   L + WTTF+KARL CS PG   
Sbjct: 241 DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG 300

Query: 352 VPFYYNELQSAFHL----PEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQE 407
           +  +++ELQ  F +    P+  ++YGVFTT+ N    SAVC +++S + + F GP+ +++
Sbjct: 301 IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD 360

Query: 408 NPRAAWLPIANPIPNFQCGTLPET-----GPNENLTERSLQDAQRLFLMSEAVQPVTPEP 462
            P   W+P    +P  + GT P          ++L +  +  A+    M   V P+   P
Sbjct: 361 GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP 420

Query: 463 CVTQDSV--RFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRS---LHGCYLEEL 517
            V +  V  +F+ +VVD V A+D  Y V++IGT+ GT+LK +S    +   L    LEE+
Sbjct: 421 IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM 480

Query: 518 HVLPPGRREP--LRSLRILHSARALFVGLRDGVLRVPLERCAAY-RSQGACLGARDPYCG 574
            V     REP  + ++ +    + L++G   GV ++PL RC  Y ++   C  ARDPYC 
Sbjct: 481 TVF----REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCA 536

Query: 575 WDG 577
           WDG
Sbjct: 537 WDG 539


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  283 bits (723), Expect = 9e-76
 Identities = 180/476 (37%), Positives = 263/476 (55%), Gaps = 47/476 (9%)

Query: 138 LIVGARNYLFRLSLANVSLLQATE------------WASSEDTRRSCQSKGKTEEECQNY 185
           L+V AR+++F   L      QA E            W S +    +C  +GK  +EC NY
Sbjct: 73  LLVAARDHVFSFDL------QAEEEGEGLVPNKYLTWRSQDV--ENCAVRGKLTDECYNY 124

Query: 186 VRVLIVAGRKVFM-CGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQ 244
           +RVL+    +  + CGTN+FSP+C S  + +L +  E+++G ARCP+D   ++ A+ + +
Sbjct: 125 IRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFA-E 183

Query: 245 GELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLREN 304
           G LY+AT  DF   D  +YRSLG  PPLR+A+Y+SKWL EP+FV A + G   YFF RE 
Sbjct: 184 GSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFFREV 243

Query: 305 AVEH-DCGRTVYSRVARVCKNDVGGR-FLLEDTWTTFMKARLNCSRPGEVPFYYNELQS- 361
           +VE    GR  +SRVARVCK D+GG    L+  WT+F+K RLNCS PG+  FY++ LQ+ 
Sbjct: 244 SVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQAL 303

Query: 362 --AFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIA-N 418
               +L  +  ++GVFTT  NSI  SAVCAF L  I + F G F+ Q +   AW P++ +
Sbjct: 304 TGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSED 363

Query: 419 PIPNFQCGTLPETGPNENL-TERSLQDAQRLF-----LMSEAVQPVTPEPCVTQDS-VRF 471
            +P+ + G+    G      + R L D    F     L+  AV PVT +P +T  S    
Sbjct: 364 RVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALL 423

Query: 472 SHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRS--LHGCYLEELHVLPP----GRR 525
           + + VD +    +   V+++G+  GT+LK L+   RS       LEE+    P    G+R
Sbjct: 424 TQVAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSGGPEPILLEEIDAYSPARCSGKR 483

Query: 526 EPLRSLRIL-----HSARALFVGLRDGVLRVPLERCAAYRS-QGACLGARDPYCGW 575
               + RI+          LFV     ++ +PL RCA + + Q +CL ++DPYCGW
Sbjct: 484 TAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGW 539


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  276 bits (706), Expect = 8e-74
 Identities = 166/446 (37%), Positives = 256/446 (57%), Gaps = 37/446 (8%)

Query: 97  LCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGN--------QLIVGARNYLF- 147
           L  +S+   V+F +    ++   Y  +R +      PSGN        QL++  R+ L+ 
Sbjct: 12  LLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYI 71

Query: 148 ----RLSLANVSLLQATE--------WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRK 195
               ++   N++ +  TE        W S +  R +C  KGK ++EC N+++V +    +
Sbjct: 72  AGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131

Query: 196 -VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVID 254
            VF+CGTNAF+PMC   ++  L    E+I+G+ARCP+D R  + A+ +  G+LY+ATV D
Sbjct: 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVAD 190

Query: 255 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRT 313
           F   D  IYRS+G G  LRT +Y+SKW+ EP+F+ A + G + YFF RE AVEH + G+ 
Sbjct: 191 FLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKA 250

Query: 314 VYSRVARVCKNDVGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD--- 369
           VYSRVAR+CKND+GG + +LE  WT+F+KARLNCS PG+  FY++ LQS   + + +   
Sbjct: 251 VYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIP 310

Query: 370 LIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTL 428
            + GVFTT +NSI  SAVCAF++  I + F G F+ Q+ P + W  +  + +P  + G  
Sbjct: 311 TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCC 370

Query: 429 PETGPNE------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRF--SHLVVDLVQ 480
            + G  E      +  + +L   +   LM  AV P+  EP  T+  VR+  + + VD   
Sbjct: 371 AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430

Query: 481 AKDTLYHVLYIGTESGTILKALSTAS 506
                Y V+++G+E+G +LK L+  S
Sbjct: 431 GPYQNYTVIFVGSEAGMVLKVLAKTS 456


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score =  276 bits (706), Expect = 8e-74
 Identities = 186/532 (34%), Positives = 273/532 (51%), Gaps = 46/532 (8%)

Query: 106 VAFEDLQPW--VSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEW 162
           ++F++LQ W  +  F+      +  L +D    +L VGA N++  L+L N+S   +   W
Sbjct: 33  LSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAW 92

Query: 163 ASSEDTRRSCQSKGKT-EEECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTI 220
            +  + R  C   GK    EC N+V++L    R  +  CGT AF P C   +VG+  R  
Sbjct: 93  PAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGH--RAE 150

Query: 221 EKI---------NGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPP 271
           E +         +G  + PYDPRH + +V+  + ELY+    D  GRD  I+RSLG  P 
Sbjct: 151 EPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE-ELYSGVAADLMGRDFTIFRSLGQRPS 209

Query: 272 LRTAQYNSKWLNEPNFVAAYDIGLF-------AYFFLRENAVE--HDCGRTVYSRVARVC 322
           LRT  ++S+WLNEP FV  + I           YFF RE AVE     GR   SRV ++C
Sbjct: 210 LRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQIC 269

Query: 323 KNDVGGRFLLEDTWTTFMKARLNCSRPG-EVPFYYNELQSAFHLPEQD----LIYGVFTT 377
           +NDVGG+  L + WTTF+KARL CS PG E   ++++LQ  F L  +D    L+Y VF+T
Sbjct: 270 RNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFST 329

Query: 378 NVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPET-----G 432
           + +    SAVC ++++ + +AF GPF ++E P   W+     +P  + G  P        
Sbjct: 330 SSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFS 389

Query: 433 PNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQ--DSVRFSHLVVDLVQAKDTLYHVLY 490
             ++  +  +Q A+   LM  +V P    P   Q   +  F+ +  D V A D  Y VL+
Sbjct: 390 STKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLF 449

Query: 491 IGTESGTILKALST---ASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDG 547
           IGT+ GT+LK +S    +  S  G  LEELHV        + S++I      L+V  R  
Sbjct: 450 IGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDS--AAVTSMQISSKRHQLYVASRSA 507

Query: 548 VLRVPLERCAAY-RSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598
           V ++ L RCAA+ R    C  ARDPYC WDG    C+  + S+      Q++
Sbjct: 508 VAQIALHRCAAHGRVCTECCLARDPYCAWDG--VACTRFQPSAKRRFRRQDV 557


>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score =  272 bits (696), Expect = 1e-72
 Identities = 186/532 (34%), Positives = 273/532 (51%), Gaps = 47/532 (8%)

Query: 106 VAFEDLQPW--VSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEW 162
           ++F++LQ W  +  F+      +  L +D    +L VGA N++  L+L N+S   +   W
Sbjct: 33  LSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAW 92

Query: 163 ASSEDTRRSCQSKGKT-EEECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTI 220
            +  + R  C   GK    EC N+V++L    R  +  CGT AF P C   +VG+  R  
Sbjct: 93  PAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGH--RAE 150

Query: 221 EKI---------NGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPP 271
           E +         +G  + PYDPRH + +V+  + ELY+    D  GRD  I+RSLG  P 
Sbjct: 151 EPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE-ELYSGVAADLMGRDFTIFRSLGQRPS 209

Query: 272 LRTAQYNSKWLNEPNFVAAYDIGLF-------AYFFLRENAVE--HDCGRTVYSRVARVC 322
           LRT  ++S+WLNEP FV  + I           YFF RE AVE     GR   SRV ++C
Sbjct: 210 LRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQIC 269

Query: 323 KNDVGGRFLLEDTWTTFMKARLNCSRPG-EVPFYYNELQSAFHLPEQD----LIYGVFTT 377
           +NDVGG+  L + WTTF+KARL CS PG E   ++++LQ  F L  +D    L+Y VF+T
Sbjct: 270 RNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFST 329

Query: 378 NVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPET-----G 432
           + +    SAVC ++++ + +AF GPF ++E P   W+     +P  + G  P        
Sbjct: 330 S-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFS 388

Query: 433 PNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQ--DSVRFSHLVVDLVQAKDTLYHVLY 490
             ++  +  +Q A+   LM  +V P    P   Q   +  F+ +  D V A D  Y VL+
Sbjct: 389 STKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLF 448

Query: 491 IGTESGTILKALST---ASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDG 547
           IGT+ GT+LK +S    +  S  G  LEELHV        + S++I      L+V  R  
Sbjct: 449 IGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDS--AAVTSMQISSKRHQLYVASRSA 506

Query: 548 VLRVPLERCAAY-RSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598
           V ++ L RCAA+ R    C  ARDPYC WDG    C+  + S+      Q++
Sbjct: 507 VAQIALHRCAAHGRVCTECCLARDPYCAWDG--VACTRFQPSAKRRFRRQDV 556


>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score =  270 bits (691), Expect = 4e-72
 Identities = 198/596 (33%), Positives = 285/596 (47%), Gaps = 70/596 (11%)

Query: 105 TVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWAS 164
           TV+  +L   V  F+  G +DF  L L      L VGAR  LF  S+  + L  A  W +
Sbjct: 32  TVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEA 91

Query: 165 SEDTRRSCQSKGKTEE-ECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEK 222
             + +  C  KGK  + EC N++R L       +++CGT AF P CT   V  L+ T+E 
Sbjct: 92  PVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCT--YVNMLTFTLEH 149

Query: 223 ---INGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNS 279
               +G  +CPYDP      ++   GELY+AT+ +F G +P I R++G    ++T +Y +
Sbjct: 150 GEFEDGKGKCPYDPAKGHAGLLVD-GELYSATLNNFLGTEPIILRNMGPHHSMKT-EYLA 207

Query: 280 KWLNEPNFV-AAY---DIGLFA------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGG 328
            WLNEP+FV +AY    +G F       YFF RE AVE DC    V +RVARVCK D+GG
Sbjct: 208 FWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGG 267

Query: 329 RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD----LIYGVFTTNVNSIAA 384
              L+  WTTF+KARL CS P     Y+N+LQ+   L +        +GVF      +  
Sbjct: 268 ARTLQRKWTTFLKARLACSAPNW-QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYL 326

Query: 385 SAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNEN-------L 437
           SA+C + L  I + F GP++        W    +P+P+ + G+        +       L
Sbjct: 327 SAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLEL 386

Query: 438 TERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKD-TLYHVLYIGTESG 496
            +  L   ++  LM E V P    P + +    F+HLV D V   D   Y VL+IGT  G
Sbjct: 387 PDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDG 446

Query: 497 TILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERC 556
            +LKA+S     +H   +EEL +     +EP+RSL +  S + LF G R  ++++P+  C
Sbjct: 447 WLLKAVSLGPW-VH--LIEELQLFD---QEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500

Query: 557 AAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWS 616
             YRS   C+ ARDPYC W     RC  +   S  SL  Q++                  
Sbjct: 501 MKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSG-SLLIQHV------------------ 541

Query: 617 PWQPCEHLDGDNSGSCLCRARSCDSPRPR----CGGLDCLGPAIHIANCSRNGAWT 668
                  +  D SG C  R      P P+      G D + P  H+++   +  WT
Sbjct: 542 -------MTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPC-HLSSNLAHARWT 589


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  268 bits (684), Expect = 3e-71
 Identities = 143/370 (38%), Positives = 179/370 (48%), Gaps = 40/370 (10%)

Query: 610  GGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCSR-----N 664
            GGF  WS W+ C    G        R+R C+ P P  GG  C G  + + NC       +
Sbjct: 4530 GGFSQWSAWRACSVTCGKGIQK---RSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVD 4586

Query: 665  GAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIF 724
            G+W+ WS W  C+ SCG G Q R R+C+NP+ +HGGR C G + E   CN   PCPV   
Sbjct: 4587 GSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIR-PCPVHGA 4645

Query: 725  WASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPEGCPEVRRNTP 778
            W++W  W  CS +CG G Q+R R C N      G+ C G   + + CN   CP   +   
Sbjct: 4646 WSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWAT 4705

Query: 779  WTPWLPVNVT-QGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDAL 837
            W  W   +V+  GGARQ  R    C  P+      Q+G R+ E     +D    C++D  
Sbjct: 4706 WASWSACSVSCGGGARQRTR---GCSDPVP-----QYGGRKCEGSDVQSD---FCNSD-- 4752

Query: 838  VEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAA 897
                       P    G W+ W  W +CSR C  G   R RTC NP P NGG  C G  +
Sbjct: 4753 -----------PCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDS 4801

Query: 898  EYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEA 957
            + Q CN   CPV G+W  W SWS CSASCGGG   R R C  P P  G   C G  T+  
Sbjct: 4802 QIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVT 4861

Query: 958  LCATQACPEG 967
             C  QACP G
Sbjct: 4862 RCNVQACPGG 4871



 Score =  235 bits (599), Expect = 2e-61
 Identities = 124/365 (33%), Positives = 166/365 (45%), Gaps = 37/365 (10%)

Query: 664  NGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPI 723
            +G ++ WS+W  CS +CG G Q R R C+ P P +GG+ C G   E R C +N PCPV  
Sbjct: 4529 HGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNC-QNKPCPVDG 4587

Query: 724  FWASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPEGCPEVRRNT 777
             W+ W  W +C+ +CG G Q+R R C N      G  C G  VE   CN   CP     +
Sbjct: 4588 SWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWS 4647

Query: 778  PWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDAL 837
             W PW   + + G   Q                     R R      PA G   CD    
Sbjct: 4648 AWQPWGTCSESCGKGTQT--------------------RARLCNNPPPAFGGSYCDG--- 4684

Query: 838  VEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAA 897
             E  ++  +     + G WA W  WS+CS  C  G R R R C++P P+ GG  C G   
Sbjct: 4685 AETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDV 4744

Query: 898  EYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEA 957
            +   CN   CP  G WS W+ W  CS +C GG  +R R+C +P PS G   C G  ++  
Sbjct: 4745 QSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQ 4804

Query: 958  LCATQACP--EGWSPWSEWSKCT---DDGAQSRSRHCEELLP--GSSACAGNSSQSRPCP 1010
             C T  CP    W  W  WS+C+     G ++R R C+  +P  G   C G+++Q   C 
Sbjct: 4805 RCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCN 4864

Query: 1011 YSEIP 1015
                P
Sbjct: 4865 VQACP 4869



 Score =  209 bits (531), Expect = 2e-53
 Identities = 115/319 (36%), Positives = 149/319 (46%), Gaps = 43/319 (13%)

Query: 601  CPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIAN 660
            CPV     DG +  WS W+ C    G  + +   R R+C++P  + GG  C G A+ I  
Sbjct: 4583 CPV-----DGSWSEWSLWEECTRSCGRGNQT---RTRTCNNPSVQHGGRPCEGNAVEIIM 4634

Query: 661  CS-----RNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNE 715
            C+      +GAW+ W  W  CS SCG G Q R R C+NP P  GG  C G   + + CNE
Sbjct: 4635 CNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNE 4694

Query: 716  NTPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPEG 769
               CP+   WA+W SWS CS +CGGG + R R C +      G  C G  V+   CN + 
Sbjct: 4695 RN-CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDP 4753

Query: 770  CPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGS 829
            CP     +PW+ W   + T  G  Q +R+R TC  P     G   G   ++ + C  D  
Sbjct: 4754 CPTHGNWSPWSGWGTCSRTCNGG-QMRRYR-TCDNPPPSNGGRACGGPDSQIQRCNTD-- 4809

Query: 830  GSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGG 889
              C  D                  G W +W  WS CS  C  G + RKR C +P P  GG
Sbjct: 4810 -MCPVD------------------GSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGG 4850

Query: 890  LPCVGDAAEYQDCNPQACP 908
             PC GD  +   CN QACP
Sbjct: 4851 RPCPGDTTQVTRCNVQACP 4869



 Score =  138 bits (348), Expect = 3e-32
 Identities = 65/172 (37%), Positives = 88/172 (51%), Gaps = 7/172 (4%)

Query: 852  VSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRG 911
            V GG++ W  W +CS  C  G + R R C  P P NGG PC G   E ++C  + CPV G
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDG 4587

Query: 912  AWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACP--EGWS 969
            +WS W+ W  C+ SCG G+  RTR+C +P+   G   C G   E  +C  + CP    WS
Sbjct: 4588 SWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWS 4647

Query: 970  PWSEWSKCTDD---GAQSRSRHCEELLP--GSSACAGNSSQSRPCPYSEIPV 1016
             W  W  C++    G Q+R+R C    P  G S C G  +Q + C     P+
Sbjct: 4648 AWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPI 4699



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 43/119 (36%), Positives = 57/119 (47%), Gaps = 12/119 (10%)

Query: 904  PQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQA 963
            P    V G +S W++W  CS +CG G  +R+R C  P P+ G   C G   E   C  + 
Sbjct: 4523 PVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKP 4582

Query: 964  CP--EGWSPWSEWSKCTDD---GAQSRSRHCE--ELLPGSSACAGNSSQ-----SRPCP 1010
            CP    WS WS W +CT     G Q+R+R C    +  G   C GN+ +      RPCP
Sbjct: 4583 CPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCP 4641



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 22/89 (24%)

Query: 574  GWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCL 633
            G D + QRC+T                CPV     DG +G W  W  C    G   G   
Sbjct: 4798 GPDSQIQRCNT--------------DMCPV-----DGSWGSWHSWSQCSASCG---GGEK 4835

Query: 634  CRARSCDSPRPRCGGLDCLGPAIHIANCS 662
             R R CD P P  GG  C G    +  C+
Sbjct: 4836 TRKRLCDHPVPVKGGRPCPGDTTQVTRCN 4864


>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score =  267 bits (682), Expect = 5e-71
 Identities = 180/502 (35%), Positives = 273/502 (54%), Gaps = 34/502 (6%)

Query: 115 VSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVS---LLQATEWASSEDTRRS 171
           +S F   G +DF  L L   GN L VGAR  +  L + +     L     W +S+  +  
Sbjct: 53  LSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSE 112

Query: 172 CQSKGKTEE-ECQNYVRVLIVAG-RKVFMCGTNAFSPMCTSRQVGN---LSRTIEKI-NG 225
           C  K K+ E +C N++RVL+      ++ CGT AFSP CT  ++ +   L  + +K+  G
Sbjct: 113 CAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEG 172

Query: 226 VARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLN-E 284
             + P+DP H  TAV+   G LY+ T+ +F G +P + R+LGS P L+T  +  +WL+ +
Sbjct: 173 KGQSPFDPAHKHTAVLVD-GMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHD 230

Query: 285 PNFVAAYDIGLFAYFFLRENAVEHDCGRTVY-SRVARVCKNDVGGRFLLEDTWTTFMKAR 343
            +FVAA       YFF  E A E D    ++ SRVARVCKNDVGG  LL+  WTTF+KA+
Sbjct: 231 ASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQ 290

Query: 344 LNCSRPGEVPFYYNELQSAFHLPEQD----LIYGVFTT--NVNSIAASAVCAFNLSAISQ 397
           L C++PG++PF  N ++ A  LP        IY VFT+   V    +SAVCAF+L  I +
Sbjct: 291 LLCTQPGQLPF--NVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIER 348

Query: 398 AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQP 457
            F G ++      + W     P  N + G+    GP+   ++++L   +  FLM E    
Sbjct: 349 VFKGKYKELNKETSRWTTYRGPETNPRPGSC-SVGPS---SDKALTFMKDHFLMDE---Q 401

Query: 458 VTPEPCVTQDSVRFSHLVVDLVQAKDTLYH-VLYIGTESGTILKALSTASRSLHGCYLEE 516
           V   P + +  V ++ L V+  Q  D   H V+Y+GT +G++ KA+ +   S H   +EE
Sbjct: 402 VVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAH--LVEE 459

Query: 517 LHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWD 576
           + + P    EP+R+L++  +  A+FVG   GV RVP   C+ Y S   C+ ARDP+C WD
Sbjct: 460 IQLFPD--PEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWD 517

Query: 577 GKQQRCSTLEDSSNMSLWTQNI 598
            + + C  L  + N++ W Q++
Sbjct: 518 PESRTCCLL-SAPNLNSWKQDM 538


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  261 bits (668), Expect = 2e-69
 Identities = 192/605 (31%), Positives = 294/605 (48%), Gaps = 73/605 (12%)

Query: 99  ALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQ 158
           A +  P + +E  +  +  F  P   ++S L L    + L +GAR  +F ++  N+S  Q
Sbjct: 23  AFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82

Query: 159 -ATEWASSEDTRRSCQSKGKTEE-ECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGN 215
               W  SED +  C  KGK+++ EC NY+RVL  ++   +++CGTNAF P C    + +
Sbjct: 83  HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTS 142

Query: 216 LSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTA 275
                +  +G  RCP+DP H+ T+V+   GELY+ T  +F G +P I R+  S  PLRT 
Sbjct: 143 FKFLGKNEDGKGRCPFDPAHSYTSVMVD-GELYSGTSYNFLGSEPIISRN-SSHSPLRT- 199

Query: 276 QYNSKWLNEPNFVAAYDIGLF----------AYFFLRENAVEHD-CGRTVYSRVARVCKN 324
           +Y   WLNEP+FV A  I              YFF  E +VE++   R +  R+ARVCK 
Sbjct: 200 EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKG 259

Query: 325 DVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDL----IYGVFTTNVN 380
           D GG   L+  WT+F+KARL CSRP +    +N L+  F L    L     Y +FT  +N
Sbjct: 260 DQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLN 318

Query: 381 SIAASAVCAFNLSAISQAFNGPFRYQ----ENPRAAWLPIANPIPNFQCGTLPETGPNE- 435
           ++  SAVCA+NLS   + F+     Q    E     W+    P+P  + G   ++     
Sbjct: 319 NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAA 378

Query: 436 ------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKD-TLYHV 488
                 NL +++LQ  +   LM ++V P+   P + +  V ++ +VVD  QA D T+Y V
Sbjct: 379 NYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDV 438

Query: 489 LYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSA--RALFVGLRD 546
           +++ T+ G + KA+S    ++H   +EE  +      EP+++L +      R ++ G   
Sbjct: 439 MFVSTDRGALHKAIS-LEHAVH--IIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNS 493

Query: 547 GVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNV 606
           GV++ PL  C  + +   C+ ARDPYC W      C  L             T  P R +
Sbjct: 494 GVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQ-----------TESPSRGL 542

Query: 607 TRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDS-PRPRCGGLDCLGPAIHIANCSRNG 665
            ++              + GD S   +C A S    P P    L CLG   H+ +   + 
Sbjct: 543 IQE--------------MSGDAS---VCPASSPKPLPPPGSSSLSCLG---HVGDRRLSS 582

Query: 666 AWTPW 670
            WTPW
Sbjct: 583 PWTPW 587


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  261 bits (666), Expect = 4e-69
 Identities = 178/539 (33%), Positives = 268/539 (49%), Gaps = 70/539 (12%)

Query: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQAT-EWASSEDTRRSCQSKGK-TEEEC 182
           D+  L  D   +++ VG+++Y+  L L +++       WA+S      C   GK    EC
Sbjct: 56  DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115

Query: 183 QNYVRVLIVAGRK-VFMCGTNAFSPMCT-----------------------SRQVGNLSR 218
            N+VR++    R  +++CGT A++PMCT                       SR      R
Sbjct: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175

Query: 219 TI--------------EKI-NGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIY 263
            +              E++ +G  +CPYDP+ ++ + + ++ ELYA   IDF G D AI+
Sbjct: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINE-ELYAGVYIDFMGTDAAIF 234

Query: 264 RSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFA-------YFFLRENAVEHDCGRTVYS 316
           R+LG    +RT QYNS+WLN+P+F+ A  I   A       YFF RE + E      VY+
Sbjct: 235 RTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYA 294

Query: 317 RVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGE--VPFYYNELQSAFHLPEQD----L 370
           R+ R+C ND GG   L + W+TF+KARL CS PGE  +  +++ELQ  F    QD    +
Sbjct: 295 RIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPV 354

Query: 371 IYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGT--- 427
           IY VFT++ +    SAVC ++++ I   FNGPF ++E P   W+P +  +P  + GT   
Sbjct: 355 IYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPG 414

Query: 428 ---LPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSV--RFSHLVVDLVQAK 482
               P     ++  +  +   +   LM +AV P+   P V +     R + + VD V A 
Sbjct: 415 GTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAA 474

Query: 483 DTLYHVLYIGTESGTILK--ALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARAL 540
           D  Y VL++GT+ GT+ K   L    + L    LEE+ V       P++++ I    + L
Sbjct: 475 DGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKD--PAPVKTMTISSKRQQL 532

Query: 541 FVGLRDGVLRVPLERCAAYRSQGA-CLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598
           +V    GV  + L RC AY +  A C  ARDPYC WDG  Q CS    SS      Q++
Sbjct: 533 YVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDG--QACSRYTASSKRRSRRQDV 589


>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  253 bits (647), Expect = 6e-67
 Identities = 176/522 (33%), Positives = 257/522 (49%), Gaps = 53/522 (10%)

Query: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATE-----WASSEDTRRSCQSKGKT- 178
           +++ L L   G  L VGAR  LF LS +N+S L   E     W +  + ++ C  KGK  
Sbjct: 69  NYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127

Query: 179 EEECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPY 231
           + +CQNY+++L+ ++G  +F CGT AFSPMCT   + N +   ++       +G  RCP+
Sbjct: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPF 187

Query: 232 DPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVA-A 290
           DP   STA++   GELY  TV  F G DPAI RS    P    +  N  WL +P FVA A
Sbjct: 188 DPNFKSTALVVD-GELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN--WLQDPAFVASA 244

Query: 291 Y---DIGLFA------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGGRFLLEDTWTTFM 340
           Y    +G         YFF  E   E +    T+ SR+AR+CK D GG  +L+  WT+F+
Sbjct: 245 YIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFL 304

Query: 341 KARLNCSRPGEVPFYYNELQSAFHLP------EQDLIYGVFTT--NVNSIAASAVCAFNL 392
           KA+L CSRP +  F +N LQ  F L          L YGVFT+  +  +   SAVC F +
Sbjct: 305 KAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363

Query: 393 SAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRL---- 448
             + + F+G ++        W  + +P+P  + G        E     SLQ   R+    
Sbjct: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423

Query: 449 ---FLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTA 505
              FLM   V+       + Q   R+  + V  V      Y VL++GT  G + KA+S  
Sbjct: 424 KDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480

Query: 506 SRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGAC 565
            R +H   +EEL +   G  +P+++L +      L+     GV++VP+  C+ YRS G C
Sbjct: 481 PR-VH--IIEELQIFSSG--QPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDC 535

Query: 566 LGARDPYCGWDGKQ-QRCSTLEDSSNMSLWTQNITACPVRNV 606
           L ARDPYC W G   +  S  +       W Q+I     +++
Sbjct: 536 LLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  253 bits (647), Expect = 6e-67
 Identities = 176/522 (33%), Positives = 257/522 (49%), Gaps = 53/522 (10%)

Query: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATE-----WASSEDTRRSCQSKGKT- 178
           +++ L L   G  L VGAR  LF LS +N+S L   E     W +  + ++ C  KGK  
Sbjct: 69  NYTALLLSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127

Query: 179 EEECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPY 231
           + +CQNY+++L+ ++G  +F CGT AFSPMCT   + N +   ++       +G  RCP+
Sbjct: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPF 187

Query: 232 DPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVA-A 290
           DP   STA++   GELY  TV  F G DPAI RS    P    +  N  WL +P FVA A
Sbjct: 188 DPNFKSTALVVD-GELYTGTVSSFQGNDPAISRSQSLRPTKTESSLN--WLQDPAFVASA 244

Query: 291 Y---DIGLFA------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGGRFLLEDTWTTFM 340
           Y    +G         YFF  E   E +    T+ SR+AR+CK D GG  +L+  WT+F+
Sbjct: 245 YIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFL 304

Query: 341 KARLNCSRPGEVPFYYNELQSAFHLP------EQDLIYGVFTT--NVNSIAASAVCAFNL 392
           KA+L CSRP +  F +N LQ  F L          L YGVFT+  +  +   SAVC F +
Sbjct: 305 KAQLLCSRPDD-GFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363

Query: 393 SAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRL---- 448
             + + F+G ++        W  + +P+P  + G        E     SLQ   R+    
Sbjct: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423

Query: 449 ---FLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTA 505
              FLM   V+       + Q   R+  + V  V      Y VL++GT  G + KA+S  
Sbjct: 424 KDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG 480

Query: 506 SRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGAC 565
            R +H   +EEL +   G  +P+++L +      L+     GV++VP+  C+ YRS G C
Sbjct: 481 PR-VH--IIEELQIFSSG--QPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDC 535

Query: 566 LGARDPYCGWDGKQ-QRCSTLEDSSNMSLWTQNITACPVRNV 606
           L ARDPYC W G   +  S  +       W Q+I     +++
Sbjct: 536 LLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDL 577


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  253 bits (645), Expect = 1e-66
 Identities = 173/526 (32%), Positives = 269/526 (51%), Gaps = 41/526 (7%)

Query: 99  ALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQ 158
           A +  P + +E  +  +  F  P   ++S L L    + L +GAR  +F ++  N+S  Q
Sbjct: 23  AFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82

Query: 159 -ATEWASSEDTRRSCQSKGKTEE-ECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGN 215
               W  SED +  C  KGK+++ EC NY+RVL  ++   +++CGTNAF P C    + +
Sbjct: 83  HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTS 142

Query: 216 LSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTA 275
                +  +G  RCP+DP H+ T+V+   GELY+ T  +F G +P I R+  S  PLRT 
Sbjct: 143 FKFLGKNEDGKGRCPFDPAHSYTSVMVD-GELYSGTSYNFLGSEPIISRN-SSHSPLRT- 199

Query: 276 QYNSKWLNEPNFVAAYDIGLF----------AYFFLRENAVEHD-CGRTVYSRVARVCKN 324
           +Y   WLNEP+FV A  I              YFF  E +VE++   R +  R+ARVCK 
Sbjct: 200 EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKG 259

Query: 325 DVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDL----IYGVFTTNVN 380
           D GG   L+  WT+F+KARL CSRP +    +N L+  F L    L     Y +FT  +N
Sbjct: 260 DQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLN 318

Query: 381 SIAASAVCAFNLSAISQAFNGPFRYQ----ENPRAAWLPIANPIPNFQCGTLPETGPNE- 435
           ++  SAVCA+NLS   + F+     Q    E     W+    P+P  + G   ++     
Sbjct: 319 NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAA 378

Query: 436 ------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKD-TLYHV 488
                 NL +++LQ  +   LM ++V P+   P + +  V ++ +VVD  QA D T+Y V
Sbjct: 379 NYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDV 438

Query: 489 LYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSA--RALFVGLRD 546
           +++ T+ G + KA+S    ++H   +EE  +      EP+++L +      R ++ G   
Sbjct: 439 MFVSTDRGALHKAIS-LEHAVH--IIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNS 493

Query: 547 GVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMS 592
           GV++ PL  C  + +   C+ ARDPYC W      C  L  + + S
Sbjct: 494 GVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPS 539


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  252 bits (644), Expect = 1e-66
 Identities = 166/487 (34%), Positives = 254/487 (52%), Gaps = 37/487 (7%)

Query: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEWASSEDTRRSCQSKGKTEEE-C 182
           D+  L +D   +++ VG+++++  L++ N+S    +  W +S      C+  GK     C
Sbjct: 53  DYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHGC 112

Query: 183 QNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPYDPRH 235
            N+VRV+    R  +++CG+ AFSP+CT    G  S     +      +G  RC ++P  
Sbjct: 113 GNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNV 172

Query: 236 NSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDI-- 293
           N+ +V+ ++ EL++   IDF G D AI+RSL     +RT Q+NSKWL+EP FV A+ I  
Sbjct: 173 NTVSVMINE-ELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPD 231

Query: 294 -----GLFAYFFLRENAVEHDCG-RTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCS 347
                    YFF +E   +++   + ++S +AR+C ND GG   L + WTTF+KARL CS
Sbjct: 232 GTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCS 291

Query: 348 RPGE--VPFYYNELQSAFHL----PEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNG 401
              E     +++EL+  F L    P   L+YG+FTT+ +    SAVC ++LS I   FNG
Sbjct: 292 VTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNG 351

Query: 402 PFRYQENPRAAWLPIANPIPNFQCGTLPETG--PNENLTERSLQDAQRLF----LMSEAV 455
           PF ++E P    +     IP  + GT P     PN   T+    D         LM  ++
Sbjct: 352 PFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSI 411

Query: 456 QPVTPEPCVTQ--DSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILK--ALSTASRSLHG 511
            P+   P + +     +++ + VD V A D  YHVL++GT+ GT+ K   L T +     
Sbjct: 412 YPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSVSGE 471

Query: 512 CYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGA-CLGARD 570
             LEEL V       P+ +++I    + L+V   +GV +V L RC  Y +  A C  ARD
Sbjct: 472 LILEELEVFK--NHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARD 529

Query: 571 PYCGWDG 577
           PYC WDG
Sbjct: 530 PYCAWDG 536


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  251 bits (640), Expect = 4e-66
 Identities = 165/491 (33%), Positives = 251/491 (51%), Gaps = 38/491 (7%)

Query: 122 GARDFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEWASSEDTRRSCQSKGKTEE 180
           G  D   + LD    +L VG R+ ++ LSL  +S   +   W S+      C  KGK   
Sbjct: 54  GFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAG 113

Query: 181 ECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVG-NLSRTIEKIN------GVARCPYD 232
           EC NYVRVL    R  +  CGT AF P+C   +VG +L   +  +       G  RCP+D
Sbjct: 114 ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFD 173

Query: 233 PRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYD 292
           P  +  + +    EL+A    D+  RD AI+RS+G    +RT   + + L EP FV +Y 
Sbjct: 174 PSSSFISTLIGS-ELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYM 232

Query: 293 I-------GLFAYFFLRENAVE-HDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARL 344
           I           YFF  E A+E  +    +Y+RV R+C NDVGG+ +L + W+TF+KARL
Sbjct: 233 IPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARL 292

Query: 345 NCSRPG--EVPFYYNELQSAFHLPEQD----LIYGVFTTNVNSIAASAVCAFNLSAISQA 398
            CS PG   +  Y++EL+  F LP +D    +I+G+F T  N     A+C +++S+I  A
Sbjct: 293 VCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAA 352

Query: 399 FNGPFRYQENPRAAWLPIANPIPNFQCGTLPET------GPNENLTERSLQDAQRLFLMS 452
           FNGP+ ++E P   W      +P  + G+          G  ++  + +++ A+   LM 
Sbjct: 353 FNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMY 412

Query: 453 EAVQPVTPEPCV--TQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASR--- 507
           +A++P   +P +  T        + VD V+A+D  Y VL+IGT++G +LK ++  ++   
Sbjct: 413 QAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEME 472

Query: 508 SLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGA-CL 566
           S+    LEEL +       P+ S+ I    + L++G    V +V    C  Y S  A C 
Sbjct: 473 SMEEVILEELQIFKD--PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCC 530

Query: 567 GARDPYCGWDG 577
            ARDPYC WDG
Sbjct: 531 LARDPYCAWDG 541


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  249 bits (635), Expect = 1e-65
 Identities = 167/512 (32%), Positives = 266/512 (51%), Gaps = 43/512 (8%)

Query: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEWASSEDTRRSCQSKGK-TEEEC 182
           DF  L LD    +L++GA++++F LSL +++   +   W ++++    C+  GK    EC
Sbjct: 69  DFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTEC 128

Query: 183 QNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTI-------EKINGVARCPYDPR 234
            N++RVL    +  +++CGT AF P+C    +G     I          +G  +CP+DP+
Sbjct: 129 ANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQ 188

Query: 235 HNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPP---LRTAQYNSKWLNEPNFVAAY 291
               +V++ +  LY+ T  DF G+D A  RSLG       +RT      WLN   F+  +
Sbjct: 189 QPFASVMTDE-YLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTF 247

Query: 292 DIGLF-------AYFFLRENAVEHDCG-RTVYSRVARVCKNDVGGRFLLEDTWTTFMKAR 343
            I           YFF RE++ E     +T+ SRV RVCKNDVGG+  L + WTTF+KAR
Sbjct: 248 FIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKAR 307

Query: 344 LNCSRPGE--VPFYYNELQSAFHLPEQD----LIYGVFTTNVNSIAASAVCAFNLSAISQ 397
           L CS PG      Y++ELQ  + LP +D    ++YGVFTT  +    SAVC ++++ I  
Sbjct: 308 LICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRA 367

Query: 398 AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPE------TGPNENLTERSLQDAQRLFLM 451
            FNGP+ ++E+    W+     IP  + GT P            +  +  +   +R  +M
Sbjct: 368 VFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVM 427

Query: 452 SEAVQPVTPEPCVTQDSV--RFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASR-- 507
            ++V PV   P   + +V  R + +VVD V A+D  Y V+++GT+ GT+LK +S +    
Sbjct: 428 YKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISKEKW 487

Query: 508 SLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAY-RSQGACL 566
           ++    LEEL +        + ++ +    + L++G RDG++++ L RC  Y ++   C 
Sbjct: 488 NMEEVVLEELQIFK--HSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCC 545

Query: 567 GARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598
            ARDPYC WDG    CS    +S      Q++
Sbjct: 546 LARDPYCAWDG--NACSRYAPTSKRRARRQDV 575


>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score =  216 bits (551), Expect = 8e-56
 Identities = 172/560 (30%), Positives = 251/560 (44%), Gaps = 54/560 (9%)

Query: 51  ARTAEGPIMVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFED 110
           AR   GP    A P  + LL      +   +  S   +S P SE   C            
Sbjct: 6   ARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSC------------ 53

Query: 111 LQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLA-NVSLLQATEWASSEDTR 169
               ++ F  P   ++S L +DP+ + L VGAR+ +F LSL  +    +  +W   E  R
Sbjct: 54  ----LTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHR 109

Query: 170 RSCQSKGKTEEECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVAR 228
           ++C+ KGK E+EC N+V++L +A    +  CGT AF P C    V    +     +G  +
Sbjct: 110 QNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGK 169

Query: 229 CPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFV 288
           CP++P   S AV++  G LYAATV ++ G +P I R++G             WLN P FV
Sbjct: 170 CPFEPAQRSAAVMAG-GVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFV 228

Query: 289 AAYDIGLFA----------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGGRFLLEDTWT 337
           AA  +              YFF  E +   D   R    RVARVC  D+GGR  L+  WT
Sbjct: 229 AAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWT 288

Query: 338 TFMKARLNCSRP--GEVPFYYNELQSAFHLPE----QDLIYGVFTTNVNSIAASAVCAFN 391
           TF+KA L C  P  G       ++  A   PE      + YG+F++       SAVCAF 
Sbjct: 289 TFLKADLLCPGPEHGRASSVLQDV--AVLRPELGAGTPIFYGIFSSQWEGATISAVCAFR 346

Query: 392 LSAISQAFNGPFRYQENPRAAWLPIA-NPIPNFQCG-------TLPETGPNENLTERSLQ 443
              I    NGPFR  ++     LP+  N +P  + G        L   G + +L +R L 
Sbjct: 347 PQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLT 406

Query: 444 DAQRLFLMSEAVQPVTPEP-CVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKAL 502
             +   LM   V P    P  VT D+     +   +       Y VLY+GTE G + +A+
Sbjct: 407 FIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAV 466

Query: 503 STASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQ 562
              ++      LE+L + P    +P+ ++++ HS   L VG R  V +V    C   +S 
Sbjct: 467 RIGAQL---SVLEDLALFP--EPQPVENMKLYHS--WLLVGSRTEVTQVNTTNCGRLQSC 519

Query: 563 GACLGARDPYCGWDGKQQRC 582
             C+ A+DP C W  +   C
Sbjct: 520 SECILAQDPVCAWSFRLDEC 539


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  208 bits (530), Expect = 2e-53
 Identities = 159/495 (32%), Positives = 236/495 (47%), Gaps = 43/495 (8%)

Query: 122 GARDFSQLALDPSGNQLIVGARNYLFRLSLANV-SLLQATEWASSEDTRRSCQSKGKTE- 179
           G+ +   + LD   ++L +G  + L+ L L       +   W      R  C  KG+   
Sbjct: 54  GSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPL 113

Query: 180 EECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKI------NGVARCPYD 232
            EC N+VRVL    R  +  CGT AF P C    VG+    +  +      +G  RCP++
Sbjct: 114 TECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHE 173

Query: 233 PRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYD 292
           P     +     GELY     DF GR+  I+RS G  P LR+    S  L++P FV A  
Sbjct: 174 PSRPFASTFID-GELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAAR 231

Query: 293 IGLFA-------YFFLRENAVEHDCG--RTVYSRVARVCKNDVGGRFLLEDTWTTFMKAR 343
           I   +       YFF  E     D G      SRV RVC ND GG+ +L + W+TF+KAR
Sbjct: 232 IPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKAR 291

Query: 344 LNCS--RPGEVPFYYNELQSAFHL-PEQDL---IYGVFTTNVNSIAASAVCAFNLSAISQ 397
           L CS   PG    ++++L+  F L P+      +Y +F+T        AVC ++++ I +
Sbjct: 292 LVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWE 351

Query: 398 AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPET---------GPNENLTERSLQDAQRL 448
            FNGPF +++ P+  W P    +P  + G  P           G  ++  +  LQ A+  
Sbjct: 352 VFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAH 411

Query: 449 FLMSEAVQPVTPEPCV--TQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALST-- 504
            LM   V+P    P +  T  + +   +VVD V+A+D  Y V+++GT+SG++LK ++   
Sbjct: 412 PLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQA 471

Query: 505 -ASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQG 563
             S       LEEL V       P+  + I    + L+VG R GV ++ L +C  Y +  
Sbjct: 472 GGSAEPEEVVLEELQVFKV--PTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTAC 529

Query: 564 A-CLGARDPYCGWDG 577
           A C  ARDPYC WDG
Sbjct: 530 AECCLARDPYCAWDG 544


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  201 bits (511), Expect = 3e-51
 Identities = 159/505 (31%), Positives = 236/505 (46%), Gaps = 48/505 (9%)

Query: 123 ARDFSQLALDPSGNQLIVGARNYLFRLSLANVS--LLQATEWASSEDTRRSCQSKGKTEE 180
           A+++S L L+ +  +L+VGAR  LF LS  ++     +   W +S + +  C  KGK  +
Sbjct: 53  AQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQ 112

Query: 181 -ECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNST 238
            EC N+VR L  +    ++ CGT+AF P+C +      +       G  +CPYDP    T
Sbjct: 113 TECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTSFEEGKEKCPYDPARGFT 172

Query: 239 AVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFV---------- 288
            +I   G LY AT  +F    P I RS      LRT +    WLN+  FV          
Sbjct: 173 GLIIDGG-LYTATRYEFRSI-PDIRRSRHPHS-LRTEETPMHWLNDAEFVFSVLVRESKA 229

Query: 289 AAYDIGLFAYFFLRENAVEHDCGRTVYSR-------VARVCKNDVGGRFLLEDTWTTFMK 341
           +A       Y+F  E A E   G    SR       VARVCK D+GG+ +L+  WT+F+K
Sbjct: 230 SAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLK 289

Query: 342 ARLNCSRPGEVPFYYNELQSAFHLPEQDL----IYGVFT--TNVNSIAASAVCAFNLSAI 395
           ARL C  P      Y  L+    L  +       Y  FT  T   ++ ASA+C ++L+ I
Sbjct: 290 ARLICHIP-----LYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEI 344

Query: 396 SQAFNGPFRYQENPRAAWLPIANPIPNFQCGT-----LPETGPNENLTERSLQ-DAQRLF 449
              F GP+   ++    W      +P  + G+     L   G N +    SL  D  +L 
Sbjct: 345 QAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLH 404

Query: 450 -LMSEAVQPVTPEPCVTQDSVRFSHLV-VDLVQAKDTLYHVLYIGTESGTILKALSTASR 507
            LM+  V P    P + + ++R++HL    +       Y +L++GT  G I KA+   S 
Sbjct: 405 PLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGS- 463

Query: 508 SLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLG 567
            +H   +EE  V      + + +L I     +L+VG   GV+++PL  C+ YRS   C+ 
Sbjct: 464 GMH--IIEETQVFRES--QSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRYRSCYDCIL 519

Query: 568 ARDPYCGWDGKQQRCSTLEDSSNMS 592
           ARDPYCGWD     C+     +N S
Sbjct: 520 ARDPYCGWDPGTHACAAATTIANRS 544


>gi|4505737 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score =  176 bits (446), Expect = 1e-43
 Identities = 117/389 (30%), Positives = 160/389 (41%), Gaps = 57/389 (14%)

Query: 645 RCGGLDCLGPAIHIANCSRNGA------------------WTPWSSWALCSTSCGIGFQV 686
           +C GL  LG  + + +C  N A                  W+ WS+WA CS +C  G Q+
Sbjct: 42  KCKGL--LGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQL 99

Query: 687 RQRSCSNPAPRHGGRICVGKSREE-RFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSR 745
           R R C     +  G++  G    + + C +   CP    W+ WG W  CS  C  G ++R
Sbjct: 100 RYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTR 159

Query: 746 RRACEN-----GNSCLGCGVEFKTCNPEG-CPEVRRNTPWTPWLPVNVTQGGARQEQRFR 799
           RRAC +     G  C G   E + C+ +  CP       W PW P + +  G   E +  
Sbjct: 160 RRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKET 219

Query: 800 FTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAW 859
            + +    +P       ++   + CP           L     R     P  V+GGW  W
Sbjct: 220 RSRKCSAPEPS------QKPPGKPCPG----------LAYEQRRCTGLPPCPVAGGWGPW 263

Query: 860 GPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQA-CPVRGAWSCWTS 918
           GP S C   C LG  + +RTC +P P++GG  C GDA     CN    CPV G W  W  
Sbjct: 264 GPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGE 323

Query: 919 WSPC------SASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALC-ATQACP--EGWS 969
           WSPC      S SC     Q++R  T          C G   +   C + Q CP    WS
Sbjct: 324 WSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS 383

Query: 970 PWSEWS----KCTDDGAQSRSRHCEELLP 994
            WS W      C  +  ++R R C  LLP
Sbjct: 384 EWSTWGLCMPPCGPNPTRARQRLCTPLLP 412



 Score =  148 bits (374), Expect = 3e-35
 Identities = 103/323 (31%), Positives = 123/323 (38%), Gaps = 57/323 (17%)

Query: 718  PCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNS-CLGCGV------EFKTCNPEGC 770
            PC  P  W+ W +W+ CS  C  G Q R R C   N  C G         + + C  + C
Sbjct: 74   PCRSPR-WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132

Query: 771  -PEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCP--AD 827
             PE+   + W PW P +VT     + +R      AP    H             CP  A 
Sbjct: 133  CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-------------CPGQAQ 179

Query: 828  GSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELG----FRVRKRTCTNP 883
             S +CDT  +                G WA WGPW+ CS  C  G       R R C+ P
Sbjct: 180  ESEACDTQQVCPT------------HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAP 227

Query: 884  EP--RNGGLPCVGDAAEYQDCNP-QACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSP 940
            EP  +  G PC G A E + C     CPV G W  W   SPC  +CG G     R+C  P
Sbjct: 228  EPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHP 287

Query: 941  APSPGEDICLGLHTEEALCATQA-CPEG--WSPWSEWSKCTD-----------DGAQSRS 986
             P  G   C G  T   +C T   CP    W  W EWS C              G QSR 
Sbjct: 288  VPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRG 347

Query: 987  RHCEELLPGSSACAGNSSQSRPC 1009
            R C         CAG     R C
Sbjct: 348  RTCRGRKFDGHRCAGQQQDIRHC 370



 Score =  119 bits (297), Expect = 2e-26
 Identities = 102/359 (28%), Positives = 137/359 (38%), Gaps = 62/359 (17%)

Query: 556 CAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRD-GGFGP 614
           C+   S+G+ L  R    GW+G+   CS       +  W   + AC  +    + GG+  
Sbjct: 89  CSVTCSEGSQLRYRR-CVGWNGQ---CSGKVAPGTLE-W--QLQACEDQQCCPEMGGWSG 141

Query: 615 WSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCS------RNGAWT 668
           W PW+PC       + +   R R+C+ P P+CGG  C G A     C        +GAW 
Sbjct: 142 WGPWEPCSVTCSKGTRT---RRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGAWA 197

Query: 669 PWSSWALCSTSCGIG----FQVRQRSCSNPAP--RHGGRICVGKSREERFCNENTPCPVP 722
            W  W  CS SC  G     + R R CS P P  +  G+ C G + E+R C    PCPV 
Sbjct: 198 TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA 257

Query: 723 IFWASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPE-GCPEVRR 775
             W  WG  S C   CG G    +R C +      G  C G       CN    CP    
Sbjct: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317

Query: 776 NTPWTPWLPV---NVTQGGAR----QEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADG 828
              W  W P    N+     +    Q+ R R TCR    D H  +   ++ + R C    
Sbjct: 318 WDSWGEWSPCIRRNMKSISCQEIPGQQSRGR-TCRGRKFDGH--RCAGQQQDIRHC---- 370

Query: 829 SGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELG-FRVRKRTCTNPEPR 886
                            S     + G W+ W  W  C   C     R R+R CT   P+
Sbjct: 371 ----------------YSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413


>gi|223671861 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score =  176 bits (446), Expect = 1e-43
 Identities = 117/389 (30%), Positives = 160/389 (41%), Gaps = 57/389 (14%)

Query: 645 RCGGLDCLGPAIHIANCSRNGA------------------WTPWSSWALCSTSCGIGFQV 686
           +C GL  LG  + + +C  N A                  W+ WS+WA CS +C  G Q+
Sbjct: 42  KCKGL--LGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQL 99

Query: 687 RQRSCSNPAPRHGGRICVGKSREE-RFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSR 745
           R R C     +  G++  G    + + C +   CP    W+ WG W  CS  C  G ++R
Sbjct: 100 RYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTR 159

Query: 746 RRACEN-----GNSCLGCGVEFKTCNPEG-CPEVRRNTPWTPWLPVNVTQGGARQEQRFR 799
           RRAC +     G  C G   E + C+ +  CP       W PW P + +  G   E +  
Sbjct: 160 RRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKET 219

Query: 800 FTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAW 859
            + +    +P       ++   + CP           L     R     P  V+GGW  W
Sbjct: 220 RSRKCSAPEPS------QKPPGKPCPG----------LAYEQRRCTGLPPCPVAGGWGPW 263

Query: 860 GPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQA-CPVRGAWSCWTS 918
           GP S C   C LG  + +RTC +P P++GG  C GDA     CN    CPV G W  W  
Sbjct: 264 GPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGE 323

Query: 919 WSPC------SASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALC-ATQACP--EGWS 969
           WSPC      S SC     Q++R  T          C G   +   C + Q CP    WS
Sbjct: 324 WSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS 383

Query: 970 PWSEWS----KCTDDGAQSRSRHCEELLP 994
            WS W      C  +  ++R R C  LLP
Sbjct: 384 EWSTWGLCMPPCGPNPTRARQRLCTPLLP 412



 Score =  148 bits (374), Expect = 3e-35
 Identities = 103/323 (31%), Positives = 123/323 (38%), Gaps = 57/323 (17%)

Query: 718  PCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNS-CLGCGV------EFKTCNPEGC 770
            PC  P  W+ W +W+ CS  C  G Q R R C   N  C G         + + C  + C
Sbjct: 74   PCRSPR-WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132

Query: 771  -PEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCP--AD 827
             PE+   + W PW P +VT     + +R      AP    H             CP  A 
Sbjct: 133  CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-------------CPGQAQ 179

Query: 828  GSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELG----FRVRKRTCTNP 883
             S +CDT  +                G WA WGPW+ CS  C  G       R R C+ P
Sbjct: 180  ESEACDTQQVCPT------------HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAP 227

Query: 884  EP--RNGGLPCVGDAAEYQDCNP-QACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSP 940
            EP  +  G PC G A E + C     CPV G W  W   SPC  +CG G     R+C  P
Sbjct: 228  EPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHP 287

Query: 941  APSPGEDICLGLHTEEALCATQA-CPEG--WSPWSEWSKCTD-----------DGAQSRS 986
             P  G   C G  T   +C T   CP    W  W EWS C              G QSR 
Sbjct: 288  VPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRG 347

Query: 987  RHCEELLPGSSACAGNSSQSRPC 1009
            R C         CAG     R C
Sbjct: 348  RTCRGRKFDGHRCAGQQQDIRHC 370



 Score =  119 bits (297), Expect = 2e-26
 Identities = 102/359 (28%), Positives = 137/359 (38%), Gaps = 62/359 (17%)

Query: 556 CAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRD-GGFGP 614
           C+   S+G+ L  R    GW+G+   CS       +  W   + AC  +    + GG+  
Sbjct: 89  CSVTCSEGSQLRYRR-CVGWNGQ---CSGKVAPGTLE-W--QLQACEDQQCCPEMGGWSG 141

Query: 615 WSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCS------RNGAWT 668
           W PW+PC       + +   R R+C+ P P+CGG  C G A     C        +GAW 
Sbjct: 142 WGPWEPCSVTCSKGTRT---RRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGAWA 197

Query: 669 PWSSWALCSTSCGIG----FQVRQRSCSNPAP--RHGGRICVGKSREERFCNENTPCPVP 722
            W  W  CS SC  G     + R R CS P P  +  G+ C G + E+R C    PCPV 
Sbjct: 198 TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA 257

Query: 723 IFWASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPE-GCPEVRR 775
             W  WG  S C   CG G    +R C +      G  C G       CN    CP    
Sbjct: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317

Query: 776 NTPWTPWLPV---NVTQGGAR----QEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADG 828
              W  W P    N+     +    Q+ R R TCR    D H  +   ++ + R C    
Sbjct: 318 WDSWGEWSPCIRRNMKSISCQEIPGQQSRGR-TCRGRKFDGH--RCAGQQQDIRHC---- 370

Query: 829 SGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELG-FRVRKRTCTNPEPR 886
                            S     + G W+ W  W  C   C     R R+R CT   P+
Sbjct: 371 ----------------YSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,725,684
Number of Sequences: 37866
Number of extensions: 2811702
Number of successful extensions: 9303
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 7037
Number of HSP's gapped (non-prelim): 917
length of query: 1151
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1038
effective length of database: 13,968,660
effective search space: 14499469080
effective search space used: 14499469080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.