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Search of human proteins with 91208428
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
(2315 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 4606 0.0
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 986 0.0
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 424 e-118
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 424 e-118
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 424 e-118
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 424 e-118
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 424 e-118
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 422 e-117
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 422 e-117
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 412 e-114
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 412 e-114
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 412 e-114
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 412 e-114
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 408 e-113
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 408 e-113
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 405 e-112
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 394 e-109
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 394 e-109
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 378 e-104
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 378 e-104
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 377 e-104
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 377 e-104
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 375 e-103
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 369 e-101
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 346 2e-94
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 346 2e-94
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 339 2e-92
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 322 2e-87
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 322 2e-87
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 322 2e-87
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 4606 bits (11947), Expect = 0.0
Identities = 2315/2315 (100%), Positives = 2315/2315 (100%)
Query: 1 MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPK 60
MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPK
Sbjct: 1 MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPK 60
Query: 61 QSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMV 120
QSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMV
Sbjct: 61 QSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMV 120
Query: 121 FKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALS 180
FKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALS
Sbjct: 121 FKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALS 180
Query: 181 ILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPC 240
ILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPC
Sbjct: 181 ILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPC 240
Query: 241 TDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSY 300
TDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSY
Sbjct: 241 TDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSY 300
Query: 301 TGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTK 360
TGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTK
Sbjct: 301 TGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTK 360
Query: 361 HEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE 420
HEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE
Sbjct: 361 HEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE 420
Query: 421 LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTN 480
LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTN
Sbjct: 421 LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTN 480
Query: 481 RSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLND 540
RSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLND
Sbjct: 481 RSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLND 540
Query: 541 GSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFIS 600
GSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFIS
Sbjct: 541 GSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFIS 600
Query: 601 ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDI 660
ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDI
Sbjct: 601 ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDI 660
Query: 661 TAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFP 720
TAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFP
Sbjct: 661 TAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFP 720
Query: 721 TEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQI 780
TEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQI
Sbjct: 721 TEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQI 780
Query: 781 LNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ 840
LNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ
Sbjct: 781 LNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ 840
Query: 841 ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLY 900
ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLY
Sbjct: 841 ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLY 900
Query: 901 KTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQG 960
KTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQG
Sbjct: 901 KTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQG 960
Query: 961 SLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISS 1020
SLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISS
Sbjct: 961 SLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISS 1020
Query: 1021 PVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNK 1080
PVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNK
Sbjct: 1021 PVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNK 1080
Query: 1081 LNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSL 1140
LNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSL
Sbjct: 1081 LNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSL 1140
Query: 1141 KPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLP 1200
KPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLP
Sbjct: 1141 KPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLP 1200
Query: 1201 AVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL 1260
AVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL
Sbjct: 1201 AVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL 1260
Query: 1261 TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID 1320
TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID
Sbjct: 1261 TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID 1320
Query: 1321 EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVS 1380
EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVS
Sbjct: 1321 EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVS 1380
Query: 1381 PHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIH 1440
PHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIH
Sbjct: 1381 PHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIH 1440
Query: 1441 KCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDR 1500
KCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDR
Sbjct: 1441 KCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDR 1500
Query: 1501 SPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLN 1560
SPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLN
Sbjct: 1501 SPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLN 1560
Query: 1561 ENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSS 1620
ENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSS
Sbjct: 1561 ENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSS 1620
Query: 1621 HESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR 1680
HESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR
Sbjct: 1621 HESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR 1680
Query: 1681 VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI 1740
VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI
Sbjct: 1681 VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI 1740
Query: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA 1800
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA
Sbjct: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA 1800
Query: 1801 QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ 1860
QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ
Sbjct: 1801 QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ 1860
Query: 1861 VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY 1920
VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY
Sbjct: 1861 VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY 1920
Query: 1921 AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEE 1980
AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEE
Sbjct: 1921 AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEE 1980
Query: 1981 QYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDY 2040
QYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDY
Sbjct: 1981 QYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDY 2040
Query: 2041 SAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLL 2100
SAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLL
Sbjct: 2041 SAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLL 2100
Query: 2101 HTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLS 2160
HTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLS
Sbjct: 2101 HTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLS 2160
Query: 2161 NEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMI 2220
NEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMI
Sbjct: 2161 NEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMI 2220
Query: 2221 VHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL 2280
VHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
Sbjct: 2221 VHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL 2280
Query: 2281 SLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV 2315
SLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV
Sbjct: 2281 SLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV 2315
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 986 bits (2548), Expect = 0.0
Identities = 527/963 (54%), Positives = 656/963 (68%), Gaps = 110/963 (11%)
Query: 1395 PSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEK 1454
P AT+E S D G +DG+ ++G+ D+ DG RE +E
Sbjct: 551 PVLATTEALASPGPD-GDSSPTKDGEGTEEGEKDEKSESEDG-----------EREHEED 598
Query: 1455 VMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQK 1514
DS+ E S ++ +EE N+ P +PS+
Sbjct: 599 GEKDSEKKEKS----------GVTHAAEERNQT-------------EPSPTPSS------ 629
Query: 1515 HNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENE-TSTDFSFADT 1573
+ G +P E AV T +++G + L+ + TST T
Sbjct: 630 -----PNRTAEGGHQTIP-GHEQDHTAVPT--DQTGGRRDAGPGLDPDMVTSTQVPPTAT 681
Query: 1574 NEKDADGILAAGDSEITPGFPQSPTSSVT---SENSEVFHVSEAEASNSSHESRIGLAEG 1630
E+ AG P P S SE+S V+ AE + S SR
Sbjct: 682 EEQ------YAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPA---- 731
Query: 1631 LESEKKAVIPLVIVSALTFICLVVLVGILIYWR--------------------------- 1663
+ +IPL++VSALTF+CL++L+ +L+YWR
Sbjct: 732 -PGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKG 790
Query: 1664 --KCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASS--GFTE 1719
KCFQTAHFY+EDS+SPRV+ PI PI DD+ AIP+K F KH+ +L++++ GF+E
Sbjct: 791 SRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSE 850
Query: 1720 EFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL 1779
+FE EVQ CT D+ ITA+ SNHP+NKHKNRYINI+AYDHSRVKL L KD K
Sbjct: 851 DFE-------EVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKH 903
Query: 1780 TDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQ 1839
+DYINANYVDGYN+ KAYIA QGPLKST EDFWRMIWE N +IVMITNLVEKGRRKCDQ
Sbjct: 904 SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQ 963
Query: 1840 YWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGR----VVTQYH 1895
YWP + SEEYGN +VT KS ++ A YTVR F++RNTK+KKG QKG P GR VV QYH
Sbjct: 964 YWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKG-QKGNPKGRQNERVVIQYH 1022
Query: 1896 YTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQH 1955
YTQWPDMGVPEY+LPVLTFVR+++ A+ GPV+VHCSAGVGRTGTYIV+DSMLQQI+
Sbjct: 1023 YTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD 1082
Query: 1956 EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIP 2015
+ TVN+ GFLKHIR+QRNYLVQTEEQY+FIHD L+EAIL KETEV + +H+YVN++LIP
Sbjct: 1083 KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIP 1142
Query: 2016 GPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EG 2074
G GKT+LEKQF+L++Q N + + +A K+CN+EKNR SS++P ER+RVG++ L G +G
Sbjct: 1143 GVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKG 1202
Query: 2075 TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVY 2134
TDYINASYIMGYY+SNEFIITQHPL HT KDFWRMIWDHNAQ++VM+PD Q++AEDEFVY
Sbjct: 1203 TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVY 1262
Query: 2135 WPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNP 2194
WP+++E +NCE+F VTL++++ CLSNEE++II DFILEATQDDYVLEVRHFQCPKWPNP
Sbjct: 1263 WPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP 1322
Query: 2195 DSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254
D+PIS TFELI+VIKEEA RDGP IVHDE+G V+AG CALTTL QLE EN+VDV+QV
Sbjct: 1323 DAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQV 1382
Query: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAAL--PDGNIAESLE 2312
AKMINLMRPGVF DIEQYQF+YK +LSLVST++ N ++D NGA L + + AES+E
Sbjct: 1383 AKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAESME 1442
Query: 2313 SLV 2315
SLV
Sbjct: 1443 SLV 1445
Score = 268 bits (684), Expect = 6e-71
Identities = 143/397 (36%), Positives = 219/397 (55%), Gaps = 15/397 (3%)
Query: 28 QQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDK 87
++RK + W+Y+GA ++W +C QSPI+I + +V ++L+ G+D
Sbjct: 50 RRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDN 109
Query: 88 TSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQ 147
S T++ NTGKTV I L +DY VSG FKA K+ FHWG N S+ GSEHS+ G+
Sbjct: 110 ESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSA-GSEHSINGR 168
Query: 148 KFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFG 207
+FP+EMQI+ ++ D F SF+ A+ + A++I F+V +N II G++ V
Sbjct: 169 RFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHE 228
Query: 208 KQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVL 267
K+ LDPF+L +LLP S YY Y GSLT+PPC++ V+WIVF+ V IS QL F +
Sbjct: 229 KETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIF 288
Query: 268 TMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHE--------------AVCSS 313
T +Q +V ++YL+NNFR QQ R V S H+ VCSS
Sbjct: 289 TTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSS 348
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
P +++ P N T+L V+W +P +Y I + + Y ED+ + F D +DL A
Sbjct: 349 PPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKA 408
Query: 374 ILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPT 410
++++ P+ Y+ ++ A+C N + +S ++ T
Sbjct: 409 TISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANT 445
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 918 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 957
Query: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 958 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1015
Query: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1016 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1075
Query: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1076 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1127
Query: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1128 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1187
Query: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1188 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1247
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 1248 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1307
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 1308 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1366
Query: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 1367 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1421
Query: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 1422 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1481
Query: 2271 QYQFLYKVILSLVST 2285
QYQF Y+ L + +
Sbjct: 1482 QYQFSYRAALEYLGS 1496
Score = 115 bits (288), Expect = 5e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 958 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1017
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 1018 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1076
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L EVR FQ WP+ P T L + + +
Sbjct: 1077 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1131
Query: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 1132 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1191
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F++ +L V+ E P+ +L
Sbjct: 1192 YIFIHDALLEAVTCGNTEVPARNL 1215
Score = 35.0 bits (79), Expect = 0.86
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 515 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 567
Query: 374 ILNNLLPNMSYVLQIVAICTNGL 396
L L PN Y ++ A GL
Sbjct: 568 RLQGLKPNSLYYFRLAARSPQGL 590
Score = 31.6 bits (70), Expect = 9.5
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 8/91 (8%)
Query: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 465
Query: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNG 395
D + NL+P +Y ++++A + G
Sbjct: 466 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG 496
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 1328 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 1367
Query: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 1368 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1425
Query: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1426 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1485
Query: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1486 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1537
Query: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1538 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1597
Query: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1598 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1657
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 1658 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1717
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 1718 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1776
Query: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 1777 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1831
Query: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 1832 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1891
Query: 2271 QYQFLYKVILSLVST 2285
QYQF Y+ L + +
Sbjct: 1892 QYQFSYRAALEYLGS 1906
Score = 115 bits (288), Expect = 5e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 1368 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1427
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 1428 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1486
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L EVR FQ WP+ P T L + + +
Sbjct: 1487 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1541
Query: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 1542 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1601
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F++ +L V+ E P+ +L
Sbjct: 1602 YIFIHDALLEAVTCGNTEVPARNL 1625
Score = 39.7 bits (91), Expect = 0.035
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 312 SSEPENVQADPENYTSLLVTWERPRVVYDT-MIEKFAVLYQQLDGEDQTKHEFL 364
S+ P+++ + TS+LV+W+ P V +I ++++ Y +DGED HE L
Sbjct: 610 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 663
Score = 35.0 bits (79), Expect = 0.86
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 518 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 570
Query: 374 ILNNLLPNMSYVLQIVAICTNGL 396
L L PN Y ++ A GL
Sbjct: 571 RLQGLKPNSLYYFRLAARSPQGL 593
Score = 33.1 bits (74), Expect = 3.3
Identities = 56/231 (24%), Positives = 90/231 (38%), Gaps = 30/231 (12%)
Query: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 468
Query: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGT 424
D + NL+P +Y ++++A + G G S + V T P G
Sbjct: 469 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVP---------GQ 518
Query: 425 EEIIKEEEEGKDIEEGAIVNPGRDSATN-QIRKKEPQ--------ISTTTHYNRIGTKYN 475
K E E + + P D+ N ++ K+ + I T Y G K N
Sbjct: 519 PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578
Query: 476 EAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTEL 526
R R + G ++ S+P A +DIS TS + T +
Sbjct: 579 SLYYFRLAARSPQGLGASTAEISARTMQSKP---SAPPQDISCTSPSSTSI 626
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 1315 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 1354
Query: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 1355 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1412
Query: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1413 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1472
Query: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1473 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1524
Query: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1525 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1584
Query: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1585 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1644
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 1645 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1704
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 1705 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1763
Query: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 1764 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1818
Query: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 1819 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1878
Query: 2271 QYQFLYKVILSLVST 2285
QYQF Y+ L + +
Sbjct: 1879 QYQFSYRAALEYLGS 1893
Score = 115 bits (288), Expect = 5e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 1355 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1414
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 1415 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1473
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L EVR FQ WP+ P T L + + +
Sbjct: 1474 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1528
Query: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 1529 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1588
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F++ +L V+ E P+ +L
Sbjct: 1589 YIFIHDALLEAVTCGNTEVPARNL 1612
Score = 39.7 bits (91), Expect = 0.035
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 312 SSEPENVQADPENYTSLLVTWERPRVVYDT-MIEKFAVLYQQLDGEDQTKHEFL 364
S+ P+++ + TS+LV+W+ P V +I ++++ Y +DGED HE L
Sbjct: 597 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 650
Score = 35.0 bits (79), Expect = 0.86
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 505 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 557
Query: 374 ILNNLLPNMSYVLQIVAICTNGL 396
L L PN Y ++ A GL
Sbjct: 558 RLQGLKPNSLYYFRLAARSPQGL 580
Score = 33.1 bits (74), Expect = 3.3
Identities = 56/231 (24%), Positives = 90/231 (38%), Gaps = 30/231 (12%)
Query: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 455
Query: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGT 424
D + NL+P +Y ++++A + G G S + V T P G
Sbjct: 456 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVP---------GQ 505
Query: 425 EEIIKEEEEGKDIEEGAIVNPGRDSATN-QIRKKEPQ--------ISTTTHYNRIGTKYN 475
K E E + + P D+ N ++ K+ + I T Y G K N
Sbjct: 506 PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPN 565
Query: 476 EAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTEL 526
R R + G ++ S+P A +DIS TS + T +
Sbjct: 566 SLYYFRLAARSPQGLGASTAEISARTMQSKP---SAPPQDISCTSPSSTSI 613
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 1319 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 1358
Query: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 1359 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1416
Query: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1417 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1476
Query: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1477 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1528
Query: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1529 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1588
Query: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1589 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1648
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 1649 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1708
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 1709 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1767
Query: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 1768 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1822
Query: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 1823 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1882
Query: 2271 QYQFLYKVILSLVST 2285
QYQF Y+ L + +
Sbjct: 1883 QYQFSYRAALEYLGS 1897
Score = 115 bits (288), Expect = 5e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 1359 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1418
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 1419 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1477
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L EVR FQ WP+ P T L + + +
Sbjct: 1478 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1532
Query: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 1533 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1592
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F++ +L V+ E P+ +L
Sbjct: 1593 YIFIHDALLEAVTCGNTEVPARNL 1616
Score = 39.7 bits (91), Expect = 0.035
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 312 SSEPENVQADPENYTSLLVTWERPRVVYDT-MIEKFAVLYQQLDGEDQTKHEFL 364
S+ P+++ + TS+LV+W+ P V +I ++++ Y +DGED HE L
Sbjct: 610 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 663
Score = 35.0 bits (79), Expect = 0.86
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 518 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 570
Query: 374 ILNNLLPNMSYVLQIVAICTNGL 396
L L PN Y ++ A GL
Sbjct: 571 RLQGLKPNSLYYFRLAARSPQGL 593
Score = 33.1 bits (74), Expect = 3.3
Identities = 56/231 (24%), Positives = 90/231 (38%), Gaps = 30/231 (12%)
Query: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 468
Query: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGT 424
D + NL+P +Y ++++A + G G S + V T P G
Sbjct: 469 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVP---------GQ 518
Query: 425 EEIIKEEEEGKDIEEGAIVNPGRDSATN-QIRKKEPQ--------ISTTTHYNRIGTKYN 475
K E E + + P D+ N ++ K+ + I T Y G K N
Sbjct: 519 PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578
Query: 476 EAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTEL 526
R R + G ++ S+P A +DIS TS + T +
Sbjct: 579 SLYYFRLAARSPQGLGASTAEISARTMQSKP---SAPPQDISCTSPSSTSI 626
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 917 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 956
Query: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1014
Query: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1015 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1074
Query: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1075 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1126
Query: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1127 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1186
Query: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1187 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1246
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 1247 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1306
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 1307 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1365
Query: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 1366 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1420
Query: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 1421 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1480
Query: 2271 QYQFLYKVILSLVST 2285
QYQF Y+ L + +
Sbjct: 1481 QYQFSYRAALEYLGS 1495
Score = 115 bits (288), Expect = 5e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1016
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 1017 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1075
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L EVR FQ WP+ P T L + + +
Sbjct: 1076 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1130
Query: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 1131 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1190
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F++ +L V+ E P+ +L
Sbjct: 1191 YIFIHDALLEAVTCGNTEVPARNL 1214
Score = 35.0 bits (79), Expect = 0.86
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 518 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 570
Query: 374 ILNNLLPNMSYVLQIVAICTNGL 396
L L PN Y ++ A GL
Sbjct: 571 RLQGLKPNSLYYFRLAARSPQGL 593
Score = 31.6 bits (70), Expect = 9.5
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 8/91 (8%)
Query: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 468
Query: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNG 395
D + NL+P +Y ++++A + G
Sbjct: 469 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 422 bits (1084), Expect = e-117
Identities = 264/727 (36%), Positives = 386/727 (53%), Gaps = 52/727 (7%)
Query: 1585 GDSEITPGF---PQSPTSS----VTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA 1637
GD + GF P SP S V + E +S S E + + + E+
Sbjct: 1201 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1260
Query: 1638 VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR--VISTPPTPI------ 1689
++ + + +++++ IL++ RK + E S + +++ P+
Sbjct: 1261 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1320
Query: 1690 --FPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNH 1747
P D IPI ++ L A+ G +F QE +S T ++SN
Sbjct: 1321 YQTPGMRDHPPIPITDLADNIERLKANDGL--------KFSQEYESIDPGQQFTWENSNL 1372
Query: 1748 PDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKST 1807
NK KNRY N++AYDHSRV L + G +DYINANY+DGY + AYIA QGPL T
Sbjct: 1373 EVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGPLPET 1430
Query: 1808 AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTV 1867
DFWRM+WE +VM+T L EK R KCDQYWPA G+E G VT LA YTV
Sbjct: 1431 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1490
Query: 1868 RNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG 1927
R F L K GS + R + Q+ + WPD GVPEY P+L F+R+ G
Sbjct: 1491 RTFALH----KSGSSEKRE----LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAG 1542
Query: 1928 PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD 1987
P+VVHCSAGVGRTG +IV+D+ML++++HE TV+I+G + +RSQRNY+VQTE+QYVFIH+
Sbjct: 1543 PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE 1602
Query: 1988 TLVEAILSKETEVLDSHIHAYVNAL-LIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQ 2046
L+EA TEV +++A++ L +P T +E +F+LL+ S S + +A
Sbjct: 1603 ALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLP 1662
Query: 2047 CNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKD 2105
CN+ KNR +I+P E +RV + + G EG+DYINAS++ GY Q +I TQ PL + +D
Sbjct: 1663 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1722
Query: 2106 FWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEK 2164
FWRM+W+HN+ ++VM+ + M ++ YWP + + F V MAE N +
Sbjct: 1723 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQ 1776
Query: 2165 LIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFE-LISVI-----KEEAANRDGP 2218
I+++F + +D +R FQ WP P KT E I I +E +DGP
Sbjct: 1777 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDFIGQVHKTKEQFGQDGP 1834
Query: 2219 MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV 2278
+ VH G G F L+ ++ ++ E VD++Q K + RP + +QYQ Y+
Sbjct: 1835 ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRA 1894
Query: 2279 ILSLVST 2285
L + +
Sbjct: 1895 ALEYLGS 1901
Score = 119 bits (298), Expect = 3e-26
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV ++S+ G G+DYINA+YI GY + N +I
Sbjct: 1363 QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIA 1422
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ PL T+ DFWRM+W+ VVM+ + + + YWP + C +VTL+
Sbjct: 1423 TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLD 1481
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L + E+R FQ WP+ P T L + + +A
Sbjct: 1482 TVELATYT-----VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC 1536
Query: 2214 NR--DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y + R + +Q
Sbjct: 1537 NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ 1596
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F+++ +L + E P+ +L
Sbjct: 1597 YVFIHEALLEAATCGHTEVPARNL 1620
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 422 bits (1084), Expect = e-117
Identities = 264/727 (36%), Positives = 386/727 (53%), Gaps = 52/727 (7%)
Query: 1585 GDSEITPGF---PQSPTSS----VTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA 1637
GD + GF P SP S V + E +S S E + + + E+
Sbjct: 1192 GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE 1251
Query: 1638 VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR--VISTPPTPI------ 1689
++ + + +++++ IL++ RK + E S + +++ P+
Sbjct: 1252 MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN 1311
Query: 1690 --FPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNH 1747
P D IPI ++ L A+ G +F QE +S T ++SN
Sbjct: 1312 YQTPGMRDHPPIPITDLADNIERLKANDGL--------KFSQEYESIDPGQQFTWENSNL 1363
Query: 1748 PDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKST 1807
NK KNRY N++AYDHSRV L + G +DYINANY+DGY + AYIA QGPL T
Sbjct: 1364 EVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGPLPET 1421
Query: 1808 AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTV 1867
DFWRM+WE +VM+T L EK R KCDQYWPA G+E G VT LA YTV
Sbjct: 1422 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1481
Query: 1868 RNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG 1927
R F L K GS + R + Q+ + WPD GVPEY P+L F+R+ G
Sbjct: 1482 RTFALH----KSGSSEKRE----LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAG 1533
Query: 1928 PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD 1987
P+VVHCSAGVGRTG +IV+D+ML++++HE TV+I+G + +RSQRNY+VQTE+QYVFIH+
Sbjct: 1534 PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE 1593
Query: 1988 TLVEAILSKETEVLDSHIHAYVNAL-LIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQ 2046
L+EA TEV +++A++ L +P T +E +F+LL+ S S + +A
Sbjct: 1594 ALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLP 1653
Query: 2047 CNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKD 2105
CN+ KNR +I+P E +RV + + G EG+DYINAS++ GY Q +I TQ PL + +D
Sbjct: 1654 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1713
Query: 2106 FWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEK 2164
FWRM+W+HN+ ++VM+ + M ++ YWP + + F V MAE N +
Sbjct: 1714 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQ 1767
Query: 2165 LIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFE-LISVI-----KEEAANRDGP 2218
I+++F + +D +R FQ WP P KT E I I +E +DGP
Sbjct: 1768 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDFIGQVHKTKEQFGQDGP 1825
Query: 2219 MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV 2278
+ VH G G F L+ ++ ++ E VD++Q K + RP + +QYQ Y+
Sbjct: 1826 ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRA 1885
Query: 2279 ILSLVST 2285
L + +
Sbjct: 1886 ALEYLGS 1892
Score = 119 bits (298), Expect = 3e-26
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 10/264 (3%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
QQ + + + N+ KNR +++I + SRV ++S+ G G+DYINA+YI GY + N +I
Sbjct: 1354 QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIA 1413
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
TQ PL T+ DFWRM+W+ VVM+ + + + YWP + C +VTL+
Sbjct: 1414 TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLD 1472
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
++ F L + E+R FQ WP+ P T L + + +A
Sbjct: 1473 TVELATYT-----VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC 1527
Query: 2214 NR--DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
N GPM+VH G G F + ++ +++ E +VD+Y + R + +Q
Sbjct: 1528 NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ 1587
Query: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Y F+++ +L + E P+ +L
Sbjct: 1588 YVFIHEALLEAATCGHTEVPARNL 1611
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 412 bits (1058), Expect = e-114
Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)
Query: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760
+ H P +AD+ + + ++LK QE +S T + SN NK KNRY N++
Sbjct: 925 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 983
Query: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820
AYDHSRV L + G +DYINANYVDGY AYIA QGPL T DFWRM+WE
Sbjct: 984 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1041
Query: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880
IVM+T L EK R KCDQYWP G+E YG VT LA + VR F+L K G
Sbjct: 1042 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1097
Query: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940
S + R V Q+ +T WPD GVPEY P L F+R+ GP+VVHCSAGVGRT
Sbjct: 1098 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1153
Query: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
G +IV+D+ML++I+ E TV+++G + +RSQRNY+VQTE+QY FIH+ L+EA+ TEV
Sbjct: 1154 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213
Query: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059
++AY+ L P T +E +F+ L+ S S + +A CN+ KNR +I+P
Sbjct: 1214 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1273
Query: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118
E +RV + + G EG+DYINAS+I GY Q +I TQ PL T +DFWRM+W++N+ +V
Sbjct: 1274 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1333
Query: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177
VM+ + M ++ YWP + + F V MAE N + I+++F + +D
Sbjct: 1334 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1387
Query: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233
VR FQ WP P S + I + +E +DGP+ VH G G F
Sbjct: 1388 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1447
Query: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
L+ ++ ++ E VD++Q KM+ RP + ++YQF Y+ L + +
Sbjct: 1448 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1499
Score = 117 bits (292), Expect = 2e-25
Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)
Query: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
KL ++++ + QQ + + + N+ KNR +++I + SRV + + G G+DYINA
Sbjct: 949 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1006
Query: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139
+Y+ GY N +I TQ PL T DFWRM+W+ + +VM+ + + + YWPN+
Sbjct: 1007 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1066
Query: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
+VTL+ ++ F L EVR FQ WP+ P
Sbjct: 1067 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1120
Query: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257
T L + + + N GP++VH G G F + ++ +++ E +VDVY +
Sbjct: 1121 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1180
Query: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295
+ R + +QY F+++ +L V E P+ SL
Sbjct: 1181 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1218
Score = 33.1 bits (74), Expect = 3.3
Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372
+P N++A+ + TS+ ++W PR I K+ +L+++ D + F T Y
Sbjct: 518 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 570
Query: 373 AILNNLLPNMSYVLQIVAICTNGL 396
++ +L PN Y ++ A GL
Sbjct: 571 -VVEDLKPNTEYAFRLAARSPQGL 593
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 412 bits (1058), Expect = e-114
Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)
Query: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760
+ H P +AD+ + + ++LK QE +S T + SN NK KNRY N++
Sbjct: 1330 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 1388
Query: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820
AYDHSRV L + G +DYINANYVDGY AYIA QGPL T DFWRM+WE
Sbjct: 1389 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1446
Query: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880
IVM+T L EK R KCDQYWP G+E YG VT LA + VR F+L K G
Sbjct: 1447 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1502
Query: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940
S + R V Q+ +T WPD GVPEY P L F+R+ GP+VVHCSAGVGRT
Sbjct: 1503 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1558
Query: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
G +IV+D+ML++I+ E TV+++G + +RSQRNY+VQTE+QY FIH+ L+EA+ TEV
Sbjct: 1559 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618
Query: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059
++AY+ L P T +E +F+ L+ S S + +A CN+ KNR +I+P
Sbjct: 1619 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1678
Query: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118
E +RV + + G EG+DYINAS+I GY Q +I TQ PL T +DFWRM+W++N+ +V
Sbjct: 1679 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1738
Query: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177
VM+ + M ++ YWP + + F V MAE N + I+++F + +D
Sbjct: 1739 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1792
Query: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233
VR FQ WP P S + I + +E +DGP+ VH G G F
Sbjct: 1793 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1852
Query: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
L+ ++ ++ E VD++Q KM+ RP + ++YQF Y+ L + +
Sbjct: 1853 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Score = 117 bits (292), Expect = 2e-25
Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)
Query: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
KL ++++ + QQ + + + N+ KNR +++I + SRV + + G G+DYINA
Sbjct: 1354 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1411
Query: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139
+Y+ GY N +I TQ PL T DFWRM+W+ + +VM+ + + + YWPN+
Sbjct: 1412 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1471
Query: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
+VTL+ ++ F L EVR FQ WP+ P
Sbjct: 1472 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1525
Query: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257
T L + + + N GP++VH G G F + ++ +++ E +VDVY +
Sbjct: 1526 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1585
Query: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295
+ R + +QY F+++ +L V E P+ SL
Sbjct: 1586 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1623
Score = 33.1 bits (74), Expect = 3.3
Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372
+P N++A+ + TS+ ++W PR I K+ +L+++ D + F T Y
Sbjct: 514 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 566
Query: 373 AILNNLLPNMSYVLQIVAICTNGL 396
++ +L PN Y ++ A GL
Sbjct: 567 -VVEDLKPNTEYAFRLAARSPQGL 589
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 412 bits (1058), Expect = e-114
Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)
Query: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760
+ H P +AD+ + + ++LK QE +S T + SN NK KNRY N++
Sbjct: 921 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 979
Query: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820
AYDHSRV L + G +DYINANYVDGY AYIA QGPL T DFWRM+WE
Sbjct: 980 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1037
Query: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880
IVM+T L EK R KCDQYWP G+E YG VT LA + VR F+L K G
Sbjct: 1038 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1093
Query: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940
S + R V Q+ +T WPD GVPEY P L F+R+ GP+VVHCSAGVGRT
Sbjct: 1094 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1149
Query: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
G +IV+D+ML++I+ E TV+++G + +RSQRNY+VQTE+QY FIH+ L+EA+ TEV
Sbjct: 1150 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209
Query: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059
++AY+ L P T +E +F+ L+ S S + +A CN+ KNR +I+P
Sbjct: 1210 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1269
Query: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118
E +RV + + G EG+DYINAS+I GY Q +I TQ PL T +DFWRM+W++N+ +V
Sbjct: 1270 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1329
Query: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177
VM+ + M ++ YWP + + F V MAE N + I+++F + +D
Sbjct: 1330 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1383
Query: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233
VR FQ WP P S + I + +E +DGP+ VH G G F
Sbjct: 1384 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1443
Query: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
L+ ++ ++ E VD++Q KM+ RP + ++YQF Y+ L + +
Sbjct: 1444 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1495
Score = 117 bits (292), Expect = 2e-25
Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)
Query: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
KL ++++ + QQ + + + N+ KNR +++I + SRV + + G G+DYINA
Sbjct: 945 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1002
Query: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139
+Y+ GY N +I TQ PL T DFWRM+W+ + +VM+ + + + YWPN+
Sbjct: 1003 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1062
Query: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
+VTL+ ++ F L EVR FQ WP+ P
Sbjct: 1063 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1116
Query: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257
T L + + + N GP++VH G G F + ++ +++ E +VDVY +
Sbjct: 1117 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1176
Query: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295
+ R + +QY F+++ +L V E P+ SL
Sbjct: 1177 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1214
Score = 33.1 bits (74), Expect = 3.3
Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372
+P N++A+ + TS+ ++W PR I K+ +L+++ D + F T Y
Sbjct: 514 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 566
Query: 373 AILNNLLPNMSYVLQIVAICTNGL 396
++ +L PN Y ++ A GL
Sbjct: 567 -VVEDLKPNTEYAFRLAARSPQGL 589
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 412 bits (1058), Expect = e-114
Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)
Query: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760
+ H P +AD+ + + ++LK QE +S T + SN NK KNRY N++
Sbjct: 1368 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 1426
Query: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820
AYDHSRV L + G +DYINANYVDGY AYIA QGPL T DFWRM+WE
Sbjct: 1427 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1484
Query: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880
IVM+T L EK R KCDQYWP G+E YG VT LA + VR F+L K G
Sbjct: 1485 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1540
Query: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940
S + R V Q+ +T WPD GVPEY P L F+R+ GP+VVHCSAGVGRT
Sbjct: 1541 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1596
Query: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
G +IV+D+ML++I+ E TV+++G + +RSQRNY+VQTE+QY FIH+ L+EA+ TEV
Sbjct: 1597 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
Query: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059
++AY+ L P T +E +F+ L+ S S + +A CN+ KNR +I+P
Sbjct: 1657 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1716
Query: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118
E +RV + + G EG+DYINAS+I GY Q +I TQ PL T +DFWRM+W++N+ +V
Sbjct: 1717 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1776
Query: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177
VM+ + M ++ YWP + + F V MAE N + I+++F + +D
Sbjct: 1777 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1830
Query: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233
VR FQ WP P S + I + +E +DGP+ VH G G F
Sbjct: 1831 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1890
Query: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
L+ ++ ++ E VD++Q KM+ RP + ++YQF Y+ L + +
Sbjct: 1891 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
Score = 117 bits (292), Expect = 2e-25
Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)
Query: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
KL ++++ + QQ + + + N+ KNR +++I + SRV + + G G+DYINA
Sbjct: 1392 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1449
Query: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139
+Y+ GY N +I TQ PL T DFWRM+W+ + +VM+ + + + YWPN+
Sbjct: 1450 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1509
Query: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
+VTL+ ++ F L EVR FQ WP+ P
Sbjct: 1510 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1563
Query: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257
T L + + + N GP++VH G G F + ++ +++ E +VDVY +
Sbjct: 1564 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1623
Query: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295
+ R + +QY F+++ +L V E P+ SL
Sbjct: 1624 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1661
Score = 33.1 bits (74), Expect = 3.3
Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372
+P N++A+ + TS+ ++W PR I K+ +L+++ D + F T Y
Sbjct: 527 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 579
Query: 373 AILNNLLPNMSYVLQIVAICTNGL 396
++ +L PN Y ++ A GL
Sbjct: 580 -VVEDLKPNTEYAFRLAARSPQGL 602
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 408 bits (1048), Expect = e-113
Identities = 256/761 (33%), Positives = 399/761 (52%), Gaps = 36/761 (4%)
Query: 1532 PLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITP 1591
P+ E+K ++ S + + + + N T N D+D S +
Sbjct: 42 PVKEEAKT----SNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSI 97
Query: 1592 GFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFIC 1651
G SP + +N +E NSS + E + +V +S+L I
Sbjct: 98 GITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIV 157
Query: 1652 LVVLVGILIYWRKCFQT-AHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVAD 1710
+++V ++ ++K Q +H ++ R P + P+ + K+ P V
Sbjct: 158 FIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV-PLLARSPSTNRKYPPLPVDK 216
Query: 1711 LHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVK 1768
L ++ + +E + + +C + T ++++ +NK KNRY+NI+ YDHSRV
Sbjct: 217 LEEEINRRMADDNKLFREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVH 274
Query: 1769 LAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITN 1828
L + +DYINA++++GY +IAAQGP + T DFWRMIWE N IVM+TN
Sbjct: 275 LTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 332
Query: 1829 LVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSG 1888
L E+ KC QYWP G YGN V+ + V VL YTVR F ++ G R
Sbjct: 333 LKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQV----GDMTNRKPQ 388
Query: 1889 RVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDS 1948
R++TQ+H+T WPD GVP + +L F++K G +VVHCSAGVGRTGT++V+D+
Sbjct: 389 RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA 448
Query: 1949 MLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV----LDSH 2004
ML + E V+++GF+ IR+QR +VQT+ QYVFI+ L+E L +TE+ L++H
Sbjct: 449 MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH 508
Query: 2005 IHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSR 2064
+ N IPG LE++F+ L+ IQ N +KNR IIP E +R
Sbjct: 509 LQKIYNK--IPG-TSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNR 565
Query: 2065 VGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPD 2123
V I G E TDY+NAS+I GY Q + +I +Q PLLHTI+DFWRMIW+ + +VM+ +
Sbjct: 566 VIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE 625
Query: 2124 GQNMAEDEFV-YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLE 2182
+ +++ YWP+ D ++ V L EE +C E ++D ++ T+++ +
Sbjct: 626 LEERGQEKCAQYWPS-DGLVSYGDITVELKKEE-EC----ESYTVRDLLVTNTRENKSRQ 679
Query: 2183 VRHFQCPKWPNPDSPISKTFELISVI----KEEAANRDGPMIVHDEHGGVTAGTFCALTT 2238
+R F WP P S +IS+I K++ + + P+ VH G GTFCAL+T
Sbjct: 680 IRQFHFHGWPEVGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
Query: 2239 LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVI 2279
++ +++ E +DV+Q K + L RP + +EQY+F YKV+
Sbjct: 739 VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 779
Score = 201 bits (510), Expect = 9e-51
Identities = 105/282 (37%), Positives = 167/282 (59%), Gaps = 19/282 (6%)
Query: 1713 ASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 1772
+++G EEF+ L ++Q+ + G N P N KNR + I+ Y+ +RV +
Sbjct: 520 SNNGLEEEFKKLTSI--KIQNDKMRTG------NLPANMKKNRVLQIIPYEFNRVIIP-- 569
Query: 1773 AEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK 1832
++ + TDY+NA+++DGY + +YIA+QGPL T EDFWRMIWE IVM+T L E+
Sbjct: 570 VKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER 629
Query: 1833 GRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVT 1892
G+ KC QYWP+DG YG+ V K + YTVR+ + NT+ K Q +
Sbjct: 630 GQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ--------IR 681
Query: 1893 QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQ 1951
Q+H+ WP++G+P +++ + ++ + P+ VHCSAG GRTGT+ L ++L+
Sbjct: 682 QFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE 741
Query: 1952 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993
+++ EG +++F +K +R QR ++VQT EQY F + + E I
Sbjct: 742 RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 783
Score = 116 bits (291), Expect = 2e-25
Identities = 82/269 (30%), Positives = 130/269 (48%), Gaps = 12/269 (4%)
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
Q+ AA K+ N+EKNR +I+P + SRV ++ + G +DYINAS+I GY + N+FI
Sbjct: 245 QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAA 304
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESF-KVTLMA 2153
Q P T+ DFWRMIW+ N +VM+ + + E + YWP++ C ++ + +
Sbjct: 305 QGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ----GCWTYGNIRVSV 360
Query: 2154 EEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEE 2211
E+ L + K IQ + + T + F WP+ P + L + K +
Sbjct: 361 EDVTVLVDYTVRKFCIQQ-VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK 419
Query: 2212 AANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADI 2269
A N G ++VH G GTF + ++ + E VDVY I R +
Sbjct: 420 ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTD 479
Query: 2270 EQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
QY F+Y+ +L E TSL+++
Sbjct: 480 MQYVFIYQALLEHYLYGDTELEVTSLETH 508
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 408 bits (1048), Expect = e-113
Identities = 256/761 (33%), Positives = 399/761 (52%), Gaps = 36/761 (4%)
Query: 1532 PLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITP 1591
P+ E+K ++ S + + + + N T N D+D S +
Sbjct: 42 PVKEEAKT----SNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSI 97
Query: 1592 GFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFIC 1651
G SP + +N +E NSS + E + +V +S+L I
Sbjct: 98 GITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIV 157
Query: 1652 LVVLVGILIYWRKCFQT-AHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVAD 1710
+++V ++ ++K Q +H ++ R P + P+ + K+ P V
Sbjct: 158 FIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV-PLLARSPSTNRKYPPLPVDK 216
Query: 1711 LHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVK 1768
L ++ + +E + + +C + T ++++ +NK KNRY+NI+ YDHSRV
Sbjct: 217 LEEEINRRMADDNKLFREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVH 274
Query: 1769 LAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITN 1828
L + +DYINA++++GY +IAAQGP + T DFWRMIWE N IVM+TN
Sbjct: 275 LTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 332
Query: 1829 LVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSG 1888
L E+ KC QYWP G YGN V+ + V VL YTVR F ++ G R
Sbjct: 333 LKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQV----GDMTNRKPQ 388
Query: 1889 RVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDS 1948
R++TQ+H+T WPD GVP + +L F++K G +VVHCSAGVGRTGT++V+D+
Sbjct: 389 RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA 448
Query: 1949 MLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV----LDSH 2004
ML + E V+++GF+ IR+QR +VQT+ QYVFI+ L+E L +TE+ L++H
Sbjct: 449 MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH 508
Query: 2005 IHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSR 2064
+ N IPG LE++F+ L+ IQ N +KNR IIP E +R
Sbjct: 509 LQKIYNK--IPG-TSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNR 565
Query: 2065 VGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPD 2123
V I G E TDY+NAS+I GY Q + +I +Q PLLHTI+DFWRMIW+ + +VM+ +
Sbjct: 566 VIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE 625
Query: 2124 GQNMAEDEFV-YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLE 2182
+ +++ YWP+ D ++ V L EE +C E ++D ++ T+++ +
Sbjct: 626 LEERGQEKCAQYWPS-DGLVSYGDITVELKKEE-EC----ESYTVRDLLVTNTRENKSRQ 679
Query: 2183 VRHFQCPKWPNPDSPISKTFELISVI----KEEAANRDGPMIVHDEHGGVTAGTFCALTT 2238
+R F WP P S +IS+I K++ + + P+ VH G GTFCAL+T
Sbjct: 680 IRQFHFHGWPEVGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
Query: 2239 LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVI 2279
++ +++ E +DV+Q K + L RP + +EQY+F YKV+
Sbjct: 739 VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 779
Score = 201 bits (510), Expect = 9e-51
Identities = 105/282 (37%), Positives = 167/282 (59%), Gaps = 19/282 (6%)
Query: 1713 ASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 1772
+++G EEF+ L ++Q+ + G N P N KNR + I+ Y+ +RV +
Sbjct: 520 SNNGLEEEFKKLTSI--KIQNDKMRTG------NLPANMKKNRVLQIIPYEFNRVIIP-- 569
Query: 1773 AEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK 1832
++ + TDY+NA+++DGY + +YIA+QGPL T EDFWRMIWE IVM+T L E+
Sbjct: 570 VKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER 629
Query: 1833 GRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVT 1892
G+ KC QYWP+DG YG+ V K + YTVR+ + NT+ K Q +
Sbjct: 630 GQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ--------IR 681
Query: 1893 QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQ 1951
Q+H+ WP++G+P +++ + ++ + P+ VHCSAG GRTGT+ L ++L+
Sbjct: 682 QFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE 741
Query: 1952 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993
+++ EG +++F +K +R QR ++VQT EQY F + + E I
Sbjct: 742 RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 783
Score = 116 bits (291), Expect = 2e-25
Identities = 82/269 (30%), Positives = 130/269 (48%), Gaps = 12/269 (4%)
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
Q+ AA K+ N+EKNR +I+P + SRV ++ + G +DYINAS+I GY + N+FI
Sbjct: 245 QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAA 304
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESF-KVTLMA 2153
Q P T+ DFWRMIW+ N +VM+ + + E + YWP++ C ++ + +
Sbjct: 305 QGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ----GCWTYGNIRVSV 360
Query: 2154 EEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEE 2211
E+ L + K IQ + + T + F WP+ P + L + K +
Sbjct: 361 EDVTVLVDYTVRKFCIQQ-VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK 419
Query: 2212 AANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADI 2269
A N G ++VH G GTF + ++ + E VDVY I R +
Sbjct: 420 ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTD 479
Query: 2270 EQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
QY F+Y+ +L E TSL+++
Sbjct: 480 MQYVFIYQALLEHYLYGDTELEVTSLETH 508
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 405 bits (1041), Expect = e-112
Identities = 257/750 (34%), Positives = 395/750 (52%), Gaps = 50/750 (6%)
Query: 1543 LTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVT 1602
LT+ S S GT+ + + N S T D D+ P S T++ T
Sbjct: 76 LTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFT----DARTEPWEGNSSTAATT 131
Query: 1603 SENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYW 1662
E + NS + R E + +V +S+L I +++V ++ +
Sbjct: 132 PETFP-------PSGNSDSKDR-------RDETPIIAVMVALSSLLVIVFIIIVLYMLRF 177
Query: 1663 RKCFQT-AHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTE 1719
+K Q +H ++ R P + P+ + K+ P V L +
Sbjct: 178 KKYKQAGSHSNSFRLSNGRTEDVEPQSV-PLLARSPSTNRKYPPLPVDKLEEEINRRMAD 236
Query: 1720 EFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL 1779
+ + +E + + +C + T ++++ +NK KNRY+NI+ YDHSRV L +
Sbjct: 237 DNKLFREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPD-- 292
Query: 1780 TDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQ 1839
+DYINA++++GY +IAAQGP + T DFWRMIWE N IVM+TNL E+ KC Q
Sbjct: 293 SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQ 352
Query: 1840 YWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQW 1899
YWP G YGN V+ + V VL YTVR F ++ G R R++TQ+H+T W
Sbjct: 353 YWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQV----GDMTNRKPQRLITQFHFTSW 408
Query: 1900 PDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTV 1959
PD GVP + +L F++K G +VVHCSAGVGRTGT++V+D+ML + E V
Sbjct: 409 PDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKV 468
Query: 1960 NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV----LDSHIHAYVNALLIP 2015
+++GF+ IR+QR +VQT+ QYVFI+ L+E L +TE+ L++H+ N IP
Sbjct: 469 DVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNK--IP 526
Query: 2016 GPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EG 2074
G LE++F+ L+ IQ N +KNR IIP E +RV I G E
Sbjct: 527 G-TSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEEN 585
Query: 2075 TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV- 2133
TDY+NAS+I GY Q + +I +Q PLLHTI+DFWRMIW+ + +VM+ + + +++
Sbjct: 586 TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ 645
Query: 2134 YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN 2193
YWP+ D ++ V L EE +C E ++D ++ T+++ ++R F WP
Sbjct: 646 YWPS-DGLVSYGDITVELKKEE-EC----ESYTVRDLLVTNTRENKSRQIRQFHFHGWPE 699
Query: 2194 PDSPISKTFELISVI----KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSV 2249
P S +IS+I K++ + + P+ VH G GTFCAL+T++ +++ E +
Sbjct: 700 VGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGIL 758
Query: 2250 DVYQVAKMINLMRPGVFADIEQYQFLYKVI 2279
DV+Q K + L RP + +EQY+F YKV+
Sbjct: 759 DVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 788
Score = 201 bits (510), Expect = 9e-51
Identities = 105/282 (37%), Positives = 167/282 (59%), Gaps = 19/282 (6%)
Query: 1713 ASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 1772
+++G EEF+ L ++Q+ + G N P N KNR + I+ Y+ +RV +
Sbjct: 529 SNNGLEEEFKKLTSI--KIQNDKMRTG------NLPANMKKNRVLQIIPYEFNRVIIP-- 578
Query: 1773 AEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK 1832
++ + TDY+NA+++DGY + +YIA+QGPL T EDFWRMIWE IVM+T L E+
Sbjct: 579 VKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER 638
Query: 1833 GRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVT 1892
G+ KC QYWP+DG YG+ V K + YTVR+ + NT+ K Q +
Sbjct: 639 GQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ--------IR 690
Query: 1893 QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQ 1951
Q+H+ WP++G+P +++ + ++ + P+ VHCSAG GRTGT+ L ++L+
Sbjct: 691 QFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE 750
Query: 1952 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993
+++ EG +++F +K +R QR ++VQT EQY F + + E I
Sbjct: 751 RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 792
Score = 116 bits (291), Expect = 2e-25
Identities = 82/269 (30%), Positives = 130/269 (48%), Gaps = 12/269 (4%)
Query: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
Q+ AA K+ N+EKNR +I+P + SRV ++ + G +DYINAS+I GY + N+FI
Sbjct: 254 QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAA 313
Query: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESF-KVTLMA 2153
Q P T+ DFWRMIW+ N +VM+ + + E + YWP++ C ++ + +
Sbjct: 314 QGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ----GCWTYGNIRVSV 369
Query: 2154 EEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEE 2211
E+ L + K IQ + + T + F WP+ P + L + K +
Sbjct: 370 EDVTVLVDYTVRKFCIQQ-VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK 428
Query: 2212 AANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADI 2269
A N G ++VH G GTF + ++ + E VDVY I R +
Sbjct: 429 ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTD 488
Query: 2270 EQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
QY F+Y+ +L E TSL+++
Sbjct: 489 MQYVFIYQALLEHYLYGDTELEVTSLETH 517
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 394 bits (1012), Expect = e-109
Identities = 233/631 (36%), Positives = 356/631 (56%), Gaps = 59/631 (9%)
Query: 1677 TSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSC 1734
T P P +P AI + +H+ + G F EE+E L E
Sbjct: 847 THPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE-------- 898
Query: 1735 TVDLGITA--DSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGY 1791
G TA D++ +N++KNRY NI++YDHSRV+L L DG +DYINANY+DGY
Sbjct: 899 ----GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVL---DGDPHSDYINANYIDGY 951
Query: 1792 NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGN 1851
+RP+ YIA QGP++ T +DFWRMIW+ N IVM+TNLVE GR KC +YWP D +E YG+
Sbjct: 952 HRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGD 1010
Query: 1852 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV 1911
VT + LA Y +R FT++ +KG R + +H+T WPD GVP Y+ +
Sbjct: 1011 IKVTLIETEPLAEYVIRTFTVQ--------KKGYHEIRELRLFHFTSWPDHGVPCYATGL 1062
Query: 1912 LTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQ 1971
L FVR+ + GP+VVHCSAG GRTG +I +D+ML ++EG V+IF ++ +R+Q
Sbjct: 1063 LGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQ 1122
Query: 1972 RNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLL 2030
R LVQTEEQYVF+HD ++EA L T + + Y N + ++++ +FQ L
Sbjct: 1123 RVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTL 1182
Query: 2031 S--QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ 2088
+ ++ D S L N +KNR+ ++P++R + S+ GE ++YINA+ + + Q
Sbjct: 1183 NIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQ 1242
Query: 2089 SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDE----PINC 2144
F++TQHPL +T+ DFWR+++D+N VVM+ + + A+ YWP K PI
Sbjct: 1243 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQFCMQYWPEKTSGCYGPIQV 1301
Query: 2145 ESFKVTLMAEEHKCLSNEEKLIIQDF---ILEATQDDYVLEVRHFQCPKWP-NPDSPISK 2200
E + +E +I + F + QD Y + V+H Q WP D+P SK
Sbjct: 1302 EFVSADI----------DEDIIHRIFRICNMARPQDGYRI-VQHLQYIGWPAYRDTPPSK 1350
Query: 2201 TFELISVIK------EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254
L+ V++ E+ R+G +VH +GG +GTFCA+ ++ ++++N +DV+ +
Sbjct: 1351 R-SLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHI 1409
Query: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
K + + + +EQY+F+Y+V L +S+
Sbjct: 1410 VKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 394 bits (1012), Expect = e-109
Identities = 233/631 (36%), Positives = 356/631 (56%), Gaps = 59/631 (9%)
Query: 1677 TSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSC 1734
T P P +P AI + +H+ + G F EE+E L E
Sbjct: 866 THPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE-------- 917
Query: 1735 TVDLGITA--DSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGY 1791
G TA D++ +N++KNRY NI++YDHSRV+L L DG +DYINANY+DGY
Sbjct: 918 ----GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVL---DGDPHSDYINANYIDGY 970
Query: 1792 NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGN 1851
+RP+ YIA QGP++ T +DFWRMIW+ N IVM+TNLVE GR KC +YWP D +E YG+
Sbjct: 971 HRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGD 1029
Query: 1852 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV 1911
VT + LA Y +R FT++ +KG R + +H+T WPD GVP Y+ +
Sbjct: 1030 IKVTLIETEPLAEYVIRTFTVQ--------KKGYHEIRELRLFHFTSWPDHGVPCYATGL 1081
Query: 1912 LTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQ 1971
L FVR+ + GP+VVHCSAG GRTG +I +D+ML ++EG V+IF ++ +R+Q
Sbjct: 1082 LGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQ 1141
Query: 1972 RNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLL 2030
R LVQTEEQYVF+HD ++EA L T + + Y N + ++++ +FQ L
Sbjct: 1142 RVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTL 1201
Query: 2031 S--QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ 2088
+ ++ D S L N +KNR+ ++P++R + S+ GE ++YINA+ + + Q
Sbjct: 1202 NIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQ 1261
Query: 2089 SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDE----PINC 2144
F++TQHPL +T+ DFWR+++D+N VVM+ + + A+ YWP K PI
Sbjct: 1262 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQFCMQYWPEKTSGCYGPIQV 1320
Query: 2145 ESFKVTLMAEEHKCLSNEEKLIIQDF---ILEATQDDYVLEVRHFQCPKWP-NPDSPISK 2200
E + +E +I + F + QD Y + V+H Q WP D+P SK
Sbjct: 1321 EFVSADI----------DEDIIHRIFRICNMARPQDGYRI-VQHLQYIGWPAYRDTPPSK 1369
Query: 2201 TFELISVIK------EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254
L+ V++ E+ R+G +VH +GG +GTFCA+ ++ ++++N +DV+ +
Sbjct: 1370 R-SLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHI 1428
Query: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
K + + + +EQY+F+Y+V L +S+
Sbjct: 1429 VKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 378 bits (971), Expect = e-104
Identities = 232/625 (37%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1673 LEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASS--GFTEEFETLKEFYQE 1730
LE+ RV+ +P P IP++H + + A F EEF +L +
Sbjct: 91 LEEQEQQRVMLLSRSPSGP--KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGH-- 146
Query: 1731 VQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDG-KLTDYINANYVD 1789
+Q T + +N +N+ KNRY NI+ DHSRV L+QL DG +DYINA+Y+D
Sbjct: 147 IQG-------TFELANKEENREKNRYPNILPNDHSRVILSQL---DGIPCSDYINASYID 196
Query: 1790 GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEY 1849
GY +IAAQGP + T DFWRM+WE IVM+TNL E+ KC QYWP G Y
Sbjct: 197 GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTY 256
Query: 1850 GNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSL 1909
GN V + VL YT+R F I+ G + R+V+Q H+T WPD GVP +
Sbjct: 257 GNIRVCVEDCVVLVDYTIRKFC-----IQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPI 311
Query: 1910 PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIR 1969
+L F++K GP+VVHCSAGVGRTGT+IV+D+M+ + E V++F F+ IR
Sbjct: 312 GMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIR 371
Query: 1970 SQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQ 2028
+QR +VQT+ QY FI+ L+E L +TE+ S + ++ + K LE++F+
Sbjct: 372 NQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFR 431
Query: 2029 LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYY 2087
L+ I + + N +K R IIP + +RV +S G E TDYINAS+I GY
Sbjct: 432 KLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYR 491
Query: 2088 QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCES 2146
Q + FI TQ PL HT++DFWRMIW+ + +VM+ + Q +D+ + YWP + + E
Sbjct: 492 QKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE- 550
Query: 2147 FKVTLMAEEHKCLSNEEKLIIQDFIL-----EATQDDYVLEVRHFQCPKWPNPDSPI--S 2199
+T+ E K + E + I+DF++ +A Q++ V VR F WP P
Sbjct: 551 --ITI---EIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605
Query: 2200 KTFELISVI-KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMI 2258
+LI+ + K++ + P+ VH G GTF AL+ ++ +++ E +DV+Q K +
Sbjct: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665
Query: 2259 NLMRPGVFADIEQYQFLYKVILSLV 2283
L RP + +EQY+F YKV+ +
Sbjct: 666 RLQRPHMVQTLEQYEFCYKVVQDFI 690
Score = 125 bits (314), Expect = 5e-28
Identities = 86/285 (30%), Positives = 142/285 (49%), Gaps = 16/285 (5%)
Query: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
+ ++F L +IQ + + A K+ NREKNR +I+P + SRV +S L G +DYINA
Sbjct: 134 QFREEFNSLPSGHIQGT-FELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINA 192
Query: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKD 2139
SYI GY + N+FI Q P T+ DFWRM+W+ + +VM+ + + E++ YWP++
Sbjct: 193 SYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ- 251
Query: 2140 EPINCESF-KVTLMAEEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPN--- 2193
C ++ + + E+ L + K IQ + + + ++ HF WP+
Sbjct: 252 ---GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFT--SWPDFGV 306
Query: 2194 PDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQ 2253
P +PI + + +K GP++VH G GTF + +M + E VDV++
Sbjct: 307 PFTPIGM-LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFE 365
Query: 2254 VAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
I RP + QY F+Y+ +L E +SL+ +
Sbjct: 366 FVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKH 410
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 378 bits (971), Expect = e-104
Identities = 232/625 (37%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1673 LEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASS--GFTEEFETLKEFYQE 1730
LE+ RV+ +P P IP++H + + A F EEF +L +
Sbjct: 33 LEEQEQQRVMLLSRSPSGP--KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGH-- 88
Query: 1731 VQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDG-KLTDYINANYVD 1789
+Q T + +N +N+ KNRY NI+ DHSRV L+QL DG +DYINA+Y+D
Sbjct: 89 IQG-------TFELANKEENREKNRYPNILPNDHSRVILSQL---DGIPCSDYINASYID 138
Query: 1790 GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEY 1849
GY +IAAQGP + T DFWRM+WE IVM+TNL E+ KC QYWP G Y
Sbjct: 139 GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTY 198
Query: 1850 GNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSL 1909
GN V + VL YT+R F I+ G + R+V+Q H+T WPD GVP +
Sbjct: 199 GNIRVCVEDCVVLVDYTIRKFC-----IQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPI 253
Query: 1910 PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIR 1969
+L F++K GP+VVHCSAGVGRTGT+IV+D+M+ + E V++F F+ IR
Sbjct: 254 GMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIR 313
Query: 1970 SQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQ 2028
+QR +VQT+ QY FI+ L+E L +TE+ S + ++ + K LE++F+
Sbjct: 314 NQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFR 373
Query: 2029 LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYY 2087
L+ I + + N +K R IIP + +RV +S G E TDYINAS+I GY
Sbjct: 374 KLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYR 433
Query: 2088 QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCES 2146
Q + FI TQ PL HT++DFWRMIW+ + +VM+ + Q +D+ + YWP + + E
Sbjct: 434 QKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE- 492
Query: 2147 FKVTLMAEEHKCLSNEEKLIIQDFIL-----EATQDDYVLEVRHFQCPKWPNPDSPI--S 2199
+T+ E K + E + I+DF++ +A Q++ V VR F WP P
Sbjct: 493 --ITI---EIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547
Query: 2200 KTFELISVI-KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMI 2258
+LI+ + K++ + P+ VH G GTF AL+ ++ +++ E +DV+Q K +
Sbjct: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
Query: 2259 NLMRPGVFADIEQYQFLYKVILSLV 2283
L RP + +EQY+F YKV+ +
Sbjct: 608 RLQRPHMVQTLEQYEFCYKVVQDFI 632
Score = 125 bits (314), Expect = 5e-28
Identities = 86/285 (30%), Positives = 142/285 (49%), Gaps = 16/285 (5%)
Query: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
+ ++F L +IQ + + A K+ NREKNR +I+P + SRV +S L G +DYINA
Sbjct: 76 QFREEFNSLPSGHIQGT-FELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINA 134
Query: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKD 2139
SYI GY + N+FI Q P T+ DFWRM+W+ + +VM+ + + E++ YWP++
Sbjct: 135 SYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ- 193
Query: 2140 EPINCESF-KVTLMAEEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPN--- 2193
C ++ + + E+ L + K IQ + + + ++ HF WP+
Sbjct: 194 ---GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFT--SWPDFGV 248
Query: 2194 PDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQ 2253
P +PI + + +K GP++VH G GTF + +M + E VDV++
Sbjct: 249 PFTPIGM-LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFE 307
Query: 2254 VAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
I RP + QY F+Y+ +L E +SL+ +
Sbjct: 308 FVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKH 352
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 377 bits (969), Expect = e-104
Identities = 228/603 (37%), Positives = 346/603 (57%), Gaps = 45/603 (7%)
Query: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
AI + +H+ + + G F EE+E+ + E QS D S+ +N+ KNR
Sbjct: 879 AIRVADLLQHITQMKCAEGYGFKEEYES----FFEGQSAPWD------SAKKDENRMKNR 928
Query: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815
Y NI+AYDHSRV+L Q E D +DYIN NY+DGY+RP YIA QGP++ T DFWRM+
Sbjct: 929 YGNIIAYDHSRVRL-QTIEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMV 986
Query: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
W N I+M+TNLVE GR KC +YWP D +E Y + VT ++LA Y +R F +
Sbjct: 987 WHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVE-- 1043
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
++G R + Q+H+T WPD GVP ++ +L FVR+ + GP+VVHCSA
Sbjct: 1044 ------KRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSA 1097
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
G GRTG +IV+D ML + EG V+I+ ++ +RS+R +VQTEEQYVFIHD ++EA L
Sbjct: 1098 GAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC 1157
Query: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKN 2052
+T V S + + Y + + ++++++F+ L+ ++ D S AL N EKN
Sbjct: 1158 GDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKN 1217
Query: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112
R I+P +R + ++ GE ++YINA+ + Y Q + FI+TQHPL +T+KDFWR++ D
Sbjct: 1218 RCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLD 1277
Query: 2113 HNAQLVVMIPDGQNMAEDEFVYWP----NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQ 2168
++ VVM+ D + A+ YWP ++ PI E L E +S I +
Sbjct: 1278 YHCTSVVMLND-VDPAQLCPQYWPENGVHRHGPIQVEFVSADL---EEDIISR----IFR 1329
Query: 2169 DFILEATQDDYVLEVRHFQCPKWP-NPDSPISKT--FELISVI---KEEAANRDGPMIVH 2222
+ QD Y + V+ FQ WP D+P+SK +LI + +EE +G +VH
Sbjct: 1330 IYNAARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVH 1388
Query: 2223 DEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL 2282
+GG +GTFCA++ + L + +VDV+ K + +P + ++QY+F Y+V L
Sbjct: 1389 CLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1448
Query: 2283 VST 2285
+++
Sbjct: 1449 LNS 1451
Score = 130 bits (326), Expect = 2e-29
Identities = 82/269 (30%), Positives = 131/269 (48%), Gaps = 17/269 (6%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFII 2094
Q + + +A K NR KNR +II + SRV + ++ G+ +DYIN +YI GY++ N +I
Sbjct: 911 QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIA 970
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV----YWPNKDEPINCESFKVT 2150
TQ P+ TI DFWRM+W N ++M+ N+ E V YWP+ E + KVT
Sbjct: 971 TQGPMQETIYDFWRMVWHENTASIIMVT---NLVEVGRVKCCKYWPDDTEIY--KDIKVT 1025
Query: 2151 LMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFEL--ISVI 2208
L+ E + +I+ F +E + E+R F WP+ P T L + +
Sbjct: 1026 LIETELLA-----EYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
Query: 2209 KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFAD 2268
K ++ GP++VH G G F + ++ E+E VD+Y + + R +
Sbjct: 1081 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1140
Query: 2269 IEQYQFLYKVILSLVSTRQEENPSTSLDS 2297
EQY F++ IL P++ + S
Sbjct: 1141 EEQYVFIHDAILEACLCGDTSVPASQVRS 1169
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 377 bits (969), Expect = e-104
Identities = 228/603 (37%), Positives = 346/603 (57%), Gaps = 45/603 (7%)
Query: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
AI + +H+ + + G F EE+E+ + E QS D S+ +N+ KNR
Sbjct: 892 AIRVADLLQHITQMKCAEGYGFKEEYES----FFEGQSAPWD------SAKKDENRMKNR 941
Query: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815
Y NI+AYDHSRV+L Q E D +DYIN NY+DGY+RP YIA QGP++ T DFWRM+
Sbjct: 942 YGNIIAYDHSRVRL-QTIEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMV 999
Query: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
W N I+M+TNLVE GR KC +YWP D +E Y + VT ++LA Y +R F +
Sbjct: 1000 WHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVE-- 1056
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
++G R + Q+H+T WPD GVP ++ +L FVR+ + GP+VVHCSA
Sbjct: 1057 ------KRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSA 1110
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
G GRTG +IV+D ML + EG V+I+ ++ +RS+R +VQTEEQYVFIHD ++EA L
Sbjct: 1111 GAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC 1170
Query: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKN 2052
+T V S + + Y + + ++++++F+ L+ ++ D S AL N EKN
Sbjct: 1171 GDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKN 1230
Query: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112
R I+P +R + ++ GE ++YINA+ + Y Q + FI+TQHPL +T+KDFWR++ D
Sbjct: 1231 RCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLD 1290
Query: 2113 HNAQLVVMIPDGQNMAEDEFVYWP----NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQ 2168
++ VVM+ D + A+ YWP ++ PI E L E +S I +
Sbjct: 1291 YHCTSVVMLND-VDPAQLCPQYWPENGVHRHGPIQVEFVSADL---EEDIISR----IFR 1342
Query: 2169 DFILEATQDDYVLEVRHFQCPKWP-NPDSPISKT--FELISVI---KEEAANRDGPMIVH 2222
+ QD Y + V+ FQ WP D+P+SK +LI + +EE +G +VH
Sbjct: 1343 IYNAARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVH 1401
Query: 2223 DEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL 2282
+GG +GTFCA++ + L + +VDV+ K + +P + ++QY+F Y+V L
Sbjct: 1402 CLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1461
Query: 2283 VST 2285
+++
Sbjct: 1462 LNS 1464
Score = 130 bits (326), Expect = 2e-29
Identities = 82/269 (30%), Positives = 131/269 (48%), Gaps = 17/269 (6%)
Query: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFII 2094
Q + + +A K NR KNR +II + SRV + ++ G+ +DYIN +YI GY++ N +I
Sbjct: 924 QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIA 983
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV----YWPNKDEPINCESFKVT 2150
TQ P+ TI DFWRM+W N ++M+ N+ E V YWP+ E + KVT
Sbjct: 984 TQGPMQETIYDFWRMVWHENTASIIMVT---NLVEVGRVKCCKYWPDDTEIY--KDIKVT 1038
Query: 2151 LMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFEL--ISVI 2208
L+ E + +I+ F +E + E+R F WP+ P T L + +
Sbjct: 1039 LIETELLA-----EYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093
Query: 2209 KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFAD 2268
K ++ GP++VH G G F + ++ E+E VD+Y + + R +
Sbjct: 1094 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1153
Query: 2269 IEQYQFLYKVILSLVSTRQEENPSTSLDS 2297
EQY F++ IL P++ + S
Sbjct: 1154 EEQYVFIHDAILEACLCGDTSVPASQVRS 1182
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 375 bits (964), Expect = e-103
Identities = 220/581 (37%), Positives = 330/581 (56%), Gaps = 35/581 (6%)
Query: 1714 SSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLA 1773
S GF EE+E+ + E QS + D+ + N+ KNRY NI+AYDHSRV L +
Sbjct: 885 SYGFKEEYES----FFEGQSASWDV------AKKDQNRAKNRYGNIIAYDHSRVILQPV- 933
Query: 1774 EKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKG 1833
+D +DYINANY+DGY RP YIA QGP+ T DFWRMIW+ IVM+TNLVE G
Sbjct: 934 -EDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVG 992
Query: 1834 RRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQ 1893
R KC +YWP D +E YG+F VT ++ LA Y VR FTL ++G R V Q
Sbjct: 993 RVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLE--------RRGYNEIREVKQ 1043
Query: 1894 YHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953
+H+T WPD GVP ++ +L+F+R+ + + GP+VVHCSAG GRTG YIV+D ML
Sbjct: 1044 FHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA 1103
Query: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV-LDSHIHAYVNAL 2012
+ EG V+I+ +K +RS+R +VQTEEQY+FIHD ++EA L ET + + AY + +
Sbjct: 1104 EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI 1163
Query: 2013 LIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSL 2070
I + L+ +FQ L+ +Q D S A N +KNR ++P +R + ++
Sbjct: 1164 RIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI 1223
Query: 2071 SGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED 2130
GE ++YINA+ + Y Q FI+TQ+PL +T+KDFWR+++D+ +VM+ + ++++
Sbjct: 1224 DGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE-VDLSQG 1282
Query: 2131 EFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPK 2190
YWP ++ + +V M+ C + I + L Q+ Y++ V+ FQ
Sbjct: 1283 CPQYWP-EEGMLRYGPIQVECMSCSMDC--DVINRIFRICNLTRPQEGYLM-VQQFQYLG 1338
Query: 2191 W------PNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLE 2244
W P K + +EE +G I+H +GG +G FCA+ ++ ++
Sbjct: 1339 WASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVK 1398
Query: 2245 KENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
++N VDV+ K + +P + EQY+F Y V L + +
Sbjct: 1399 RQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 369 bits (947), Expect = e-101
Identities = 220/587 (37%), Positives = 330/587 (56%), Gaps = 41/587 (6%)
Query: 1714 SSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLA 1773
S GF EE+E+ + E QS + D+ + N+ KNRY NI+AYDHSRV L +
Sbjct: 885 SYGFKEEYES----FFEGQSASWDV------AKKDQNRAKNRYGNIIAYDHSRVILQPV- 933
Query: 1774 EKDGKLTDYINANYVD------GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT 1827
+D +DYINANY+D GY RP YIA QGP+ T DFWRMIW+ IVM+T
Sbjct: 934 -EDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 992
Query: 1828 NLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPS 1887
NLVE GR KC +YWP D +E YG+F VT ++ LA Y VR FTL ++G
Sbjct: 993 NLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLE--------RRGYNE 1043
Query: 1888 GRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947
R V Q+H+T WPD GVP ++ +L+F+R+ + + GP+VVHCSAG GRTG YIV+D
Sbjct: 1044 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1103
Query: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV-LDSHIH 2006
ML + EG V+I+ +K +RS+R +VQTEEQY+FIHD ++EA L ET + +
Sbjct: 1104 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1163
Query: 2007 AYVNALLIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKNRTSSIIPVERSR 2064
AY + + I + L+ +FQ L+ +Q D S A N +KNR ++P +R
Sbjct: 1164 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1223
Query: 2065 VGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG 2124
+ ++ GE ++YINA+ + Y Q FI+TQ+PL +T+KDFWR+++D+ +VM+ +
Sbjct: 1224 PFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE- 1282
Query: 2125 QNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVR 2184
++++ YWP ++ + +V M+ C + I + L Q+ Y++ V+
Sbjct: 1283 VDLSQGCPQYWP-EEGMLRYGPIQVECMSCSMDC--DVINRIFRICNLTRPQEGYLM-VQ 1338
Query: 2185 HFQCPKW------PNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTT 2238
FQ W P K + +EE +G I+H +GG +G FCA+
Sbjct: 1339 QFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGI 1398
Query: 2239 LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
++ ++++N VDV+ K + +P + EQY+F Y V L + +
Sbjct: 1399 VVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 346 bits (887), Expect = 2e-94
Identities = 211/597 (35%), Positives = 315/597 (52%), Gaps = 46/597 (7%)
Query: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
A+ + +H+ + + G F +E+E+ E + D++ D +R
Sbjct: 863 AVRVADLLQHINQMKTAEGYGFKQEYESFFEGW--------------DATKKKDKVKGSR 908
Query: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815
+ AYD RVKL + DYINANY+DGY+R +IA QGP DFWRM+
Sbjct: 909 QEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMV 966
Query: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
W+ + IVMIT LVE GR KC +YWP D S+ YG+ + + LA Y VR F L
Sbjct: 967 WQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALE-- 1023
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
++G + V Q+H+T WP+ GVP ++ +L F+R+ + GP+V+HCSA
Sbjct: 1024 ------RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSA 1077
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
G GRTG YIVLD ML + EG V+I+ +K + S+R ++QTEEQY+FIHD ++EA L
Sbjct: 1078 GTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLC 1137
Query: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQSN--IQQSDYSAALKQCNREKN 2052
ET + S A Y + I + ++L ++FQ L+ + + S AL NR+KN
Sbjct: 1138 GETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKN 1197
Query: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112
R+ ++P +R + S G+ +YINA+ Y +S FI+T HPL T DFWR+++D
Sbjct: 1198 RSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1257
Query: 2113 HNAQLVVMIP--DGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDF 2170
+ +VM+ + N A YWP + LM E + +E L+ + F
Sbjct: 1258 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQ------QYGLMEVEFMSGTADEDLVARVF 1311
Query: 2171 ILE---ATQDDYVLEVRHFQCPKW----PNPDSPISKTFELISVIKEEAANRDGPMIVHD 2223
++ Q+ ++L VRHFQ +W PDS + L V K +A + DG IVH
Sbjct: 1312 RVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1370
Query: 2224 EHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL 2280
+GG +GTFCA T++ + N VDV+ AK + +P + ++QY F Y V L
Sbjct: 1371 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL 1427
Score = 115 bits (288), Expect = 5e-25
Identities = 82/291 (28%), Positives = 138/291 (47%), Gaps = 24/291 (8%)
Query: 1714 SSGFTEEFETLKEFYQ--EVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQ 1771
SS EEF+TL +V+ C++ L P N+ KNR ++++ D L
Sbjct: 1163 SSQLREEFQTLNSVTPPLDVEECSIAL--------LPRNRDKNRSMDVLPPDRC---LPF 1211
Query: 1772 LAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE 1831
L DG +YINA D Y R A+I PL+ST DFWR+++++ IVM+ L +
Sbjct: 1212 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1271
Query: 1832 KGRR-KCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRN-TKIKKGSQKGRPSGR 1889
C QYWP G ++YG V S R F ++N +++++G
Sbjct: 1272 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHL------- 1324
Query: 1890 VVTQYHYTQWPDM-GVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947
+V + + +W P+ L + + + G +VHC G GR+GT+
Sbjct: 1325 LVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACA 1384
Query: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET 1998
++L+ I+ V++F K +R+ + +V+T +QY F +D +E + E+
Sbjct: 1385 TVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLES 1435
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 346 bits (887), Expect = 2e-94
Identities = 211/597 (35%), Positives = 315/597 (52%), Gaps = 46/597 (7%)
Query: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
A+ + +H+ + + G F +E+E+ E + D++ D +R
Sbjct: 873 AVRVADLLQHINQMKTAEGYGFKQEYESFFEGW--------------DATKKKDKVKGSR 918
Query: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815
+ AYD RVKL + DYINANY+DGY+R +IA QGP DFWRM+
Sbjct: 919 QEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMV 976
Query: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
W+ + IVMIT LVE GR KC +YWP D S+ YG+ + + LA Y VR F L
Sbjct: 977 WQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALE-- 1033
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
++G + V Q+H+T WP+ GVP ++ +L F+R+ + GP+V+HCSA
Sbjct: 1034 ------RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSA 1087
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
G GRTG YIVLD ML + EG V+I+ +K + S+R ++QTEEQY+FIHD ++EA L
Sbjct: 1088 GTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLC 1147
Query: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQSN--IQQSDYSAALKQCNREKN 2052
ET + S A Y + I + ++L ++FQ L+ + + S AL NR+KN
Sbjct: 1148 GETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKN 1207
Query: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112
R+ ++P +R + S G+ +YINA+ Y +S FI+T HPL T DFWR+++D
Sbjct: 1208 RSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1267
Query: 2113 HNAQLVVMIP--DGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDF 2170
+ +VM+ + N A YWP + LM E + +E L+ + F
Sbjct: 1268 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQ------QYGLMEVEFMSGTADEDLVARVF 1321
Query: 2171 ILE---ATQDDYVLEVRHFQCPKW----PNPDSPISKTFELISVIKEEAANRDGPMIVHD 2223
++ Q+ ++L VRHFQ +W PDS + L V K +A + DG IVH
Sbjct: 1322 RVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1380
Query: 2224 EHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL 2280
+GG +GTFCA T++ + N VDV+ AK + +P + ++QY F Y V L
Sbjct: 1381 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL 1437
Score = 115 bits (288), Expect = 5e-25
Identities = 82/291 (28%), Positives = 138/291 (47%), Gaps = 24/291 (8%)
Query: 1714 SSGFTEEFETLKEFYQ--EVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQ 1771
SS EEF+TL +V+ C++ L P N+ KNR ++++ D L
Sbjct: 1173 SSQLREEFQTLNSVTPPLDVEECSIAL--------LPRNRDKNRSMDVLPPDRC---LPF 1221
Query: 1772 LAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE 1831
L DG +YINA D Y R A+I PL+ST DFWR+++++ IVM+ L +
Sbjct: 1222 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1281
Query: 1832 KGRR-KCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRN-TKIKKGSQKGRPSGR 1889
C QYWP G ++YG V S R F ++N +++++G
Sbjct: 1282 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHL------- 1334
Query: 1890 VVTQYHYTQWPDM-GVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947
+V + + +W P+ L + + + G +VHC G GR+GT+
Sbjct: 1335 LVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACA 1394
Query: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET 1998
++L+ I+ V++F K +R+ + +V+T +QY F +D +E + E+
Sbjct: 1395 TVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLES 1445
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 339 bits (870), Expect = 2e-92
Identities = 211/603 (34%), Positives = 315/603 (52%), Gaps = 52/603 (8%)
Query: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
A+ + +H+ + + G F +E+E+ E + D++ D +R
Sbjct: 863 AVRVADLLQHINQMKTAEGYGFKQEYESFFEGW--------------DATKKKDKVKGSR 908
Query: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVD------GYNRPKAYIAAQGPLKSTAE 1809
+ AYD RVKL + DYINANY+D GY+R +IA QGP
Sbjct: 909 QEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDIRINREGYHRSNHFIATQGPKPEMVY 966
Query: 1810 DFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRN 1869
DFWRM+W+ + IVMIT LVE GR KC +YWP D S+ YG+ + + LA Y VR
Sbjct: 967 DFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRT 1025
Query: 1870 FTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPV 1929
F L ++G + V Q+H+T WP+ GVP ++ +L F+R+ + GP+
Sbjct: 1026 FALE--------RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPI 1077
Query: 1930 VVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTL 1989
V+HCSAG GRTG YIVLD ML + EG V+I+ +K + S+R ++QTEEQY+FIHD +
Sbjct: 1078 VIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137
Query: 1990 VEAILSKETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQSN--IQQSDYSAALKQ 2046
+EA L ET + S A Y + I + ++L ++FQ L+ + + S AL
Sbjct: 1138 LEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLP 1197
Query: 2047 CNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDF 2106
NR+KNR+ ++P +R + S G+ +YINA+ Y +S FI+T HPL T DF
Sbjct: 1198 RNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
Query: 2107 WRMIWDHNAQLVVMIP--DGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEK 2164
WR+++D+ +VM+ + N A YWP + LM E + +E
Sbjct: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQ------QYGLMEVEFMSGTADED 1311
Query: 2165 LIIQDFILE---ATQDDYVLEVRHFQCPKW----PNPDSPISKTFELISVIKEEAANRDG 2217
L+ + F ++ Q+ ++L VRHFQ +W PDS + L V K +A + DG
Sbjct: 1312 LVARVFRVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG 1370
Query: 2218 PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYK 2277
IVH +GG +GTFCA T++ + N VDV+ AK + +P + ++QY F Y
Sbjct: 1371 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD 1430
Query: 2278 VIL 2280
V L
Sbjct: 1431 VAL 1433
Score = 115 bits (288), Expect = 5e-25
Identities = 82/291 (28%), Positives = 138/291 (47%), Gaps = 24/291 (8%)
Query: 1714 SSGFTEEFETLKEFYQ--EVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQ 1771
SS EEF+TL +V+ C++ L P N+ KNR ++++ D L
Sbjct: 1169 SSQLREEFQTLNSVTPPLDVEECSIAL--------LPRNRDKNRSMDVLPPDRC---LPF 1217
Query: 1772 LAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE 1831
L DG +YINA D Y R A+I PL+ST DFWR+++++ IVM+ L +
Sbjct: 1218 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1277
Query: 1832 KGRR-KCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRN-TKIKKGSQKGRPSGR 1889
C QYWP G ++YG V S R F ++N +++++G
Sbjct: 1278 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHL------- 1330
Query: 1890 VVTQYHYTQWPDM-GVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947
+V + + +W P+ L + + + G +VHC G GR+GT+
Sbjct: 1331 LVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACA 1390
Query: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET 1998
++L+ I+ V++F K +R+ + +V+T +QY F +D +E + E+
Sbjct: 1391 TVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLES 1441
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 322 bits (826), Expect = 2e-87
Identities = 211/680 (31%), Positives = 338/680 (49%), Gaps = 72/680 (10%)
Query: 1643 IVSALTFICLVVLVGILIYWRKCF-----QTAHFYLEDSTSPRVISTPPTPIFPISDDVG 1697
+++ L F+ +V + +L+ K + ++ + + R + PI D
Sbjct: 529 LIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHAD-- 586
Query: 1698 AIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYI 1757
I ++ + + +AD F EF+++ + + + P N++KNRY+
Sbjct: 587 -ILLETYKRKIAD--EGRLFLAEFQSIPRVFSK---------FPIKEARKPFNQNKNRYV 634
Query: 1758 NIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWE 1817
+I+ YD++RV+L+++ G ++YINA+Y+DG+ P+ YIAAQGP T +DFWRMIWE
Sbjct: 635 DILPYDYNRVELSEINGDAG--SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE 692
Query: 1818 HNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
VIVM+T E R KC +YWP+ +G+ +G+ +V + Y ++ + N
Sbjct: 693 QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK 752
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
K K +GR VT +T WPD GVPE +L R+ GP+VVHCSA
Sbjct: 753 KEKA-------TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSA 805
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
GVGRTGTYI +D+ML+ ++ E V+++G++ +R QR +VQ E QY+ IH LVE
Sbjct: 806 GVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF 865
Query: 1996 KETEVLDSHIHAYV-NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRT 2054
ETEV S +H Y+ N P+ + LE +FQ L ++ + ++ N+ KNR
Sbjct: 866 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRN 924
Query: 2055 SSIIPVERSRVGI--------------------SSLSGEGTDYINASYIMGYYQSNEFII 2094
S++IP + +RV + S S E + YINAS+IM Y++ I
Sbjct: 925 SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIA 984
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESFKVTLMA 2153
Q PL TI DFW+MI+ +++VM+ + ++ ++ YW + +V L
Sbjct: 985 AQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG--DIEVDL-- 1040
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPI--SKTFELISVIKEE 2211
K ++ F L ++ V +Q W P + +I V+K++
Sbjct: 1041 ---KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQK 1097
Query: 2212 AANRDG----------PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLM 2261
++ P+++H G G FCAL L+ E E VD++QV K +
Sbjct: 1098 LPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA 1157
Query: 2262 RPGVFADIEQYQFLYKVILS 2281
RPG+ + EQYQFLY VI S
Sbjct: 1158 RPGMVSTFEQYQFLYDVIAS 1177
Score = 150 bits (380), Expect = 1e-35
Identities = 92/287 (32%), Positives = 145/287 (50%), Gaps = 36/287 (12%)
Query: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKL------AQLAEKDG-----------KLTDYI 1783
T N +NK KNR N++ YD++RV L ++ +E D + + YI
Sbjct: 909 TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYI 968
Query: 1784 NANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA 1843
NA+++ Y +P+ IAAQGPLK T DFW+MI++ V+VIVM+T L + C QYW
Sbjct: 969 NASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-G 1027
Query: 1844 DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMG 1903
+G + YG+ V K + YT+R F LR++K R R V QY YT W
Sbjct: 1028 EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK--------RKDSRTVYQYQYTNWSVEQ 1079
Query: 1904 VPEYSLPVLTFVRKAAYA----------KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953
+P +++ ++ K H P+++HC G +TG + L ++L+
Sbjct: 1080 LPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESA 1139
Query: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
+ E V+IF +K +R R +V T EQY F++D + ++ +V
Sbjct: 1140 ETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 322 bits (826), Expect = 2e-87
Identities = 211/680 (31%), Positives = 338/680 (49%), Gaps = 72/680 (10%)
Query: 1643 IVSALTFICLVVLVGILIYWRKCF-----QTAHFYLEDSTSPRVISTPPTPIFPISDDVG 1697
+++ L F+ +V + +L+ K + ++ + + R + PI D
Sbjct: 577 LIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHAD-- 634
Query: 1698 AIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYI 1757
I ++ + + +AD F EF+++ + + + P N++KNRY+
Sbjct: 635 -ILLETYKRKIAD--EGRLFLAEFQSIPRVFSK---------FPIKEARKPFNQNKNRYV 682
Query: 1758 NIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWE 1817
+I+ YD++RV+L+++ G ++YINA+Y+DG+ P+ YIAAQGP T +DFWRMIWE
Sbjct: 683 DILPYDYNRVELSEINGDAG--SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE 740
Query: 1818 HNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
VIVM+T E R KC +YWP+ +G+ +G+ +V + Y ++ + N
Sbjct: 741 QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK 800
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
K K +GR VT +T WPD GVPE +L R+ GP+VVHCSA
Sbjct: 801 KEKA-------TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSA 853
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
GVGRTGTYI +D+ML+ ++ E V+++G++ +R QR +VQ E QY+ IH LVE
Sbjct: 854 GVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF 913
Query: 1996 KETEVLDSHIHAYV-NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRT 2054
ETEV S +H Y+ N P+ + LE +FQ L ++ + ++ N+ KNR
Sbjct: 914 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRN 972
Query: 2055 SSIIPVERSRVGI--------------------SSLSGEGTDYINASYIMGYYQSNEFII 2094
S++IP + +RV + S S E + YINAS+IM Y++ I
Sbjct: 973 SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIA 1032
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESFKVTLMA 2153
Q PL TI DFW+MI+ +++VM+ + ++ ++ YW + +V L
Sbjct: 1033 AQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG--DIEVDL-- 1088
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPI--SKTFELISVIKEE 2211
K ++ F L ++ V +Q W P + +I V+K++
Sbjct: 1089 ---KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQK 1145
Query: 2212 AANRDG----------PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLM 2261
++ P+++H G G FCAL L+ E E VD++QV K +
Sbjct: 1146 LPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA 1205
Query: 2262 RPGVFADIEQYQFLYKVILS 2281
RPG+ + EQYQFLY VI S
Sbjct: 1206 RPGMVSTFEQYQFLYDVIAS 1225
Score = 150 bits (380), Expect = 1e-35
Identities = 92/287 (32%), Positives = 145/287 (50%), Gaps = 36/287 (12%)
Query: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKL------AQLAEKDG-----------KLTDYI 1783
T N +NK KNR N++ YD++RV L ++ +E D + + YI
Sbjct: 957 TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYI 1016
Query: 1784 NANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA 1843
NA+++ Y +P+ IAAQGPLK T DFW+MI++ V+VIVM+T L + C QYW
Sbjct: 1017 NASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-G 1075
Query: 1844 DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMG 1903
+G + YG+ V K + YT+R F LR++K R R V QY YT W
Sbjct: 1076 EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK--------RKDSRTVYQYQYTNWSVEQ 1127
Query: 1904 VPEYSLPVLTFVRKAAYA----------KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953
+P +++ ++ K H P+++HC G +TG + L ++L+
Sbjct: 1128 LPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESA 1187
Query: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
+ E V+IF +K +R R +V T EQY F++D + ++ +V
Sbjct: 1188 ETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1234
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 322 bits (826), Expect = 2e-87
Identities = 211/680 (31%), Positives = 338/680 (49%), Gaps = 72/680 (10%)
Query: 1643 IVSALTFICLVVLVGILIYWRKCF-----QTAHFYLEDSTSPRVISTPPTPIFPISDDVG 1697
+++ L F+ +V + +L+ K + ++ + + R + PI D
Sbjct: 416 LIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHAD-- 473
Query: 1698 AIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYI 1757
I ++ + + +AD F EF+++ + + + P N++KNRY+
Sbjct: 474 -ILLETYKRKIAD--EGRLFLAEFQSIPRVFSK---------FPIKEARKPFNQNKNRYV 521
Query: 1758 NIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWE 1817
+I+ YD++RV+L+++ G ++YINA+Y+DG+ P+ YIAAQGP T +DFWRMIWE
Sbjct: 522 DILPYDYNRVELSEINGDAG--SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE 579
Query: 1818 HNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
VIVM+T E R KC +YWP+ +G+ +G+ +V + Y ++ + N
Sbjct: 580 QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK 639
Query: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
K K +GR VT +T WPD GVPE +L R+ GP+VVHCSA
Sbjct: 640 KEKA-------TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSA 692
Query: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
GVGRTGTYI +D+ML+ ++ E V+++G++ +R QR +VQ E QY+ IH LVE
Sbjct: 693 GVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF 752
Query: 1996 KETEVLDSHIHAYV-NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRT 2054
ETEV S +H Y+ N P+ + LE +FQ L ++ + ++ N+ KNR
Sbjct: 753 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRN 811
Query: 2055 SSIIPVERSRVGI--------------------SSLSGEGTDYINASYIMGYYQSNEFII 2094
S++IP + +RV + S S E + YINAS+IM Y++ I
Sbjct: 812 SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIA 871
Query: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESFKVTLMA 2153
Q PL TI DFW+MI+ +++VM+ + ++ ++ YW + +V L
Sbjct: 872 AQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG--DIEVDL-- 927
Query: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPI--SKTFELISVIKEE 2211
K ++ F L ++ V +Q W P + +I V+K++
Sbjct: 928 ---KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQK 984
Query: 2212 AANRDG----------PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLM 2261
++ P+++H G G FCAL L+ E E VD++QV K +
Sbjct: 985 LPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA 1044
Query: 2262 RPGVFADIEQYQFLYKVILS 2281
RPG+ + EQYQFLY VI S
Sbjct: 1045 RPGMVSTFEQYQFLYDVIAS 1064
Score = 150 bits (380), Expect = 1e-35
Identities = 92/287 (32%), Positives = 145/287 (50%), Gaps = 36/287 (12%)
Query: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKL------AQLAEKDG-----------KLTDYI 1783
T N +NK KNR N++ YD++RV L ++ +E D + + YI
Sbjct: 796 TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYI 855
Query: 1784 NANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA 1843
NA+++ Y +P+ IAAQGPLK T DFW+MI++ V+VIVM+T L + C QYW
Sbjct: 856 NASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-G 914
Query: 1844 DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMG 1903
+G + YG+ V K + YT+R F LR++K R R V QY YT W
Sbjct: 915 EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK--------RKDSRTVYQYQYTNWSVEQ 966
Query: 1904 VPEYSLPVLTFVRKAAYA----------KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953
+P +++ ++ K H P+++HC G +TG + L ++L+
Sbjct: 967 LPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESA 1026
Query: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
+ E V+IF +K +R R +V T EQY F++D + ++ +V
Sbjct: 1027 ETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,513,979
Number of Sequences: 37866
Number of extensions: 4064991
Number of successful extensions: 14651
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 150
Number of HSP's successfully gapped in prelim test: 223
Number of HSP's that attempted gapping in prelim test: 11864
Number of HSP's gapped (non-prelim): 1396
length of query: 2315
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2197
effective length of database: 13,779,330
effective search space: 30273188010
effective search space used: 30273188010
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.