Search of human proteins with 89242137

Search of human proteins with 89242137

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|89242137 Meckel syndrome, type 1 [Homo sapiens]
         (559 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|89242137 Meckel syndrome, type 1 [Homo sapiens]                   1132   0.0  
gi|226371646 B9 protein domain 2 [Homo sapiens]                        63   6e-10
gi|7661536 B9 protein [Homo sapiens]                                   54   5e-07
gi|7662284 microtubule associated monoxygenase, calponin and LIM...    33   0.69 
gi|35493868 otoferlin isoform b [Homo sapiens]                         32   2.0  
gi|35493860 otoferlin isoform d [Homo sapiens]                         32   2.0  
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]                32   2.0  
gi|28557790 zinc finger, CCHC domain containing 12 [Homo sapiens]      31   2.6  
gi|35493853 otoferlin isoform c [Homo sapiens]                         30   4.5  
gi|34740331 otoferlin isoform a [Homo sapiens]                         30   4.5  
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d...    30   7.6  
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c...    30   7.6  
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a...    30   7.6  
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [...    30   7.6  
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    29   10.0 
gi|66730423 hypothetical protein LOC389384 [Homo sapiens]              29   10.0 

>gi|89242137 Meckel syndrome, type 1 [Homo sapiens]
          Length = 559

 Score = 1132 bits (2929), Expect = 0.0
 Identities = 559/559 (100%), Positives = 559/559 (100%)

Query: 1   MAETVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQ 60
           MAETVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQ
Sbjct: 1   MAETVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQ 60

Query: 61  PTASGHRPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGGK 120
           PTASGHRPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGGK
Sbjct: 61  PTASGHRPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGGK 120

Query: 121 KNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRRRQDRRGMEGGILKSR 180
           KNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRRRQDRRGMEGGILKSR
Sbjct: 121 KNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRRRQDRRGMEGGILKSR 180

Query: 181 IVTWEPSEEFVRNNHVINTPLQTMHIMADLGPYKKLGYKKYEHVLCTLKVDSNGVITVKP 240
           IVTWEPSEEFVRNNHVINTPLQTMHIMADLGPYKKLGYKKYEHVLCTLKVDSNGVITVKP
Sbjct: 181 IVTWEPSEEFVRNNHVINTPLQTMHIMADLGPYKKLGYKKYEHVLCTLKVDSNGVITVKP 240

Query: 241 DFTGLKGPYRIETEGEKQELWKYTIDNVSPHAQPEEEERERRVFKDLYGRHKEYLSSLVG 300
           DFTGLKGPYRIETEGEKQELWKYTIDNVSPHAQPEEEERERRVFKDLYGRHKEYLSSLVG
Sbjct: 241 DFTGLKGPYRIETEGEKQELWKYTIDNVSPHAQPEEEERERRVFKDLYGRHKEYLSSLVG 300

Query: 301 TDFEMTVPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPTAHWSSPAFQQLSGVTQTCTT 360
           TDFEMTVPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPTAHWSSPAFQQLSGVTQTCTT
Sbjct: 301 TDFEMTVPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPTAHWSSPAFQQLSGVTQTCTT 360

Query: 361 KSLAMDKVAHFSYPFTFEAFFLHEDESSDALPEWPVLYCEVLSLDFWQRYRVEGYGAVVL 420
           KSLAMDKVAHFSYPFTFEAFFLHEDESSDALPEWPVLYCEVLSLDFWQRYRVEGYGAVVL
Sbjct: 361 KSLAMDKVAHFSYPFTFEAFFLHEDESSDALPEWPVLYCEVLSLDFWQRYRVEGYGAVVL 420

Query: 421 PATPGSHTLTVSTWRPVELGTVAELRRFFIGGSLELEDLSYVRIPGSFKGERLSRFGLRT 480
           PATPGSHTLTVSTWRPVELGTVAELRRFFIGGSLELEDLSYVRIPGSFKGERLSRFGLRT
Sbjct: 421 PATPGSHTLTVSTWRPVELGTVAELRRFFIGGSLELEDLSYVRIPGSFKGERLSRFGLRT 480

Query: 481 ETTGTVTFRLHCLQQSRAFMESSSLQKRMRSVLDRLEGFSQQSSIHNVLEAFRRARRRMQ 540
           ETTGTVTFRLHCLQQSRAFMESSSLQKRMRSVLDRLEGFSQQSSIHNVLEAFRRARRRMQ
Sbjct: 481 ETTGTVTFRLHCLQQSRAFMESSSLQKRMRSVLDRLEGFSQQSSIHNVLEAFRRARRRMQ 540

Query: 541 EARESLPQDLVSPSGTLVS 559
           EARESLPQDLVSPSGTLVS
Sbjct: 541 EARESLPQDLVSPSGTLVS 559


>gi|226371646 B9 protein domain 2 [Homo sapiens]
          Length = 175

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 24/181 (13%)

Query: 315 VNGEVVSAQGYEYDNLYVHFFVELPTAHWSSPAFQQLSGVTQTCT-TKSLAMDKVAHFSY 373
           V G+++ A G+   +L+  + +       +  A++ LSGV +  T   +  +  +A++S+
Sbjct: 6   VIGQIIGASGFSESSLFCKWGIH------TGAAWKLLSGVREGQTQVDTPQIGDMAYWSH 59

Query: 374 PFTFEAFFLHEDESSDALPEWPVLYCEVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVST 433
           P            ++  L  WP L+ +V S D + R ++ GYG   +P++PG+H L   T
Sbjct: 60  PIDLHF-------ATKGLQGWPRLHFQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLACPT 112

Query: 434 WRPVELGTVAE-LRRFFIGGSLELEDLSYVRIPGSFKGERLSRFGLRTETTGTVTFRLHC 492
           WRP  LG+  E L R F+GG  +L       + G        R+ L T   GTV   +  
Sbjct: 113 WRP--LGSWREQLARAFVGGGPQL-------LHGDTIYSGADRYRLHTAAGGTVHLEIGL 163

Query: 493 L 493
           L
Sbjct: 164 L 164


>gi|7661536 B9 protein [Homo sapiens]
          Length = 204

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 44/153 (28%), Positives = 71/153 (46%), Gaps = 14/153 (9%)

Query: 308 PGALRLFVNGEVVSAQGYEYDNLYVHFFVELPTAHWSSPAFQQLSGVTQTCTTKSLAMDK 367
           P    L VNG+V SAQ  EYD+LY  +   +    W+  A  +  G++Q  T+KS  + +
Sbjct: 6   PSVFLLMVNGQVESAQFPEYDDLYCKYCF-VYGQDWAPTAGLE-EGISQI-TSKSQDVRQ 62

Query: 368 VAHFSYPF--TFEAFFLHEDESSDALPEWPVLYCEVLSLDFWQRYRVEGYGAVVLPATPG 425
              +++P   TF++   +          WP +   V   D +    V GYGAV +P +PG
Sbjct: 63  ALVWNFPIDVTFKSTNPYG---------WPQIVLSVYGPDVFGNDVVRGYGAVHVPFSPG 113

Query: 426 SHTLTVSTWRPVELGTVAELRRFFIGGSLELED 458
            H  T+  + P     + +   +F+G   E  D
Sbjct: 114 RHKRTIPMFVPESTSKLQKFTSWFMGRRPEYTD 146


>gi|7662284 microtubule associated monoxygenase, calponin and LIM
           domain containing 2 [Homo sapiens]
          Length = 1124

 Score = 33.1 bits (74), Expect = 0.69
 Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 6/69 (8%)

Query: 121 KNRRIFTYTDSDRYTNLEEHCQRMTTA-----ASEVPSFLVERMANVRRRRQDRRGMEGG 175
           KN   +T     RY NL  HC R           E+  + +ER+ +VRR     R  E  
Sbjct: 458 KNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSR-KESD 516

Query: 176 ILKSRIVTW 184
           I  S+++TW
Sbjct: 517 IRPSKLLTW 525


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 26/114 (22%), Positives = 47/114 (41%), Gaps = 7/114 (6%)

Query: 6   WSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQPTASG 65
           W+T TGE V      V   +L   ++   +S  +     AE  K+       + +   + 
Sbjct: 494 WNT-TGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEK------KKKKKGTA 546

Query: 66  HRPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGG 119
             PEE+E +E ++ W  K F+  +    Q      S +D + ++E+   E   G
Sbjct: 547 EEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600


>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 26/114 (22%), Positives = 47/114 (41%), Gaps = 7/114 (6%)

Query: 6   WSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQPTASG 65
           W+T TGE V      V   +L   ++   +S  +     AE  K+       + +   + 
Sbjct: 494 WNT-TGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEK------KKKKKGTA 546

Query: 66  HRPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGG 119
             PEE+E +E ++ W  K F+  +    Q      S +D + ++E+   E   G
Sbjct: 547 EEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score = 31.6 bits (70), Expect = 2.0
 Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 5/56 (8%)

Query: 33  ITSSNFLHYQPAAE-LGKDLIDLATFRPQPTASGHRPEEDEEE----EIVIGWQEK 83
           ++  + +H++ A E L  D I+L  F P    SG  PEE+EE+    E+V G+  K
Sbjct: 392 VSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLK 447


>gi|28557790 zinc finger, CCHC domain containing 12 [Homo sapiens]
          Length = 402

 Score = 31.2 bits (69), Expect = 2.6
 Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 1/63 (1%)

Query: 251 IETEGEKQ-ELWKYTIDNVSPHAQPEEEERERRVFKDLYGRHKEYLSSLVGTDFEMTVPG 309
           +  +GE+  E W   ++ V P     EEE+ +R+ K L G  +E +  L  T+  ++V  
Sbjct: 53  VPAQGEETFENWLTQVNGVLPDWNMSEEEKLKRLMKTLRGPAREVMRVLQATNPNLSVAD 112

Query: 310 ALR 312
            LR
Sbjct: 113 FLR 115


>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 25/113 (22%), Positives = 45/113 (39%), Gaps = 6/113 (5%)

Query: 7   STDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQPTASGH 66
           S  TGE V      V   +L   ++   +S  +     AE  K+       + +   +  
Sbjct: 571 SHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEK------KKKKKGTAE 624

Query: 67  RPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGG 119
            PEE+E +E ++ W  K F+  +    Q      S +D + ++E+   E   G
Sbjct: 625 EPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 677


>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 25/113 (22%), Positives = 45/113 (39%), Gaps = 6/113 (5%)

Query: 7    STDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQPTASGH 66
            S  TGE V      V   +L   ++   +S  +     AE  K+       + +   +  
Sbjct: 1261 SHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEK------KKKKKGTAE 1314

Query: 67   RPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGG 119
             PEE+E +E ++ W  K F+  +    Q      S +D + ++E+   E   G
Sbjct: 1315 EPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 1367


>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
           [Homo sapiens]
          Length = 521

 Score = 29.6 bits (65), Expect = 7.6
 Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 108 RQEILKLENSGGKKNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRR 165
           R+++L+  ++ G++   +F Y +  R T LE  C    TAA+  P +L++ +  +R R
Sbjct: 293 REKLLEFSSAQGQEE--LFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPR 348


>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
           [Homo sapiens]
          Length = 590

 Score = 29.6 bits (65), Expect = 7.6
 Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 108 RQEILKLENSGGKKNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRR 165
           R+++L+  ++ G++   +F Y +  R T LE  C    TAA+  P +L++ +  +R R
Sbjct: 327 REKLLEFSSAQGQEE--LFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPR 382


>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
           [Homo sapiens]
          Length = 606

 Score = 29.6 bits (65), Expect = 7.6
 Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 108 RQEILKLENSGGKKNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRR 165
           R+++L+  ++ G++   +F Y +  R T LE  C    TAA+  P +L++ +  +R R
Sbjct: 327 REKLLEFSSAQGQEE--LFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPR 382


>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
           [Homo sapiens]
          Length = 597

 Score = 29.6 bits (65), Expect = 7.6
 Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 108 RQEILKLENSGGKKNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRR 165
           R+++L+  ++ G++   +F Y +  R T LE  C    TAA+  P +L++ +  +R R
Sbjct: 327 REKLLEFSSAQGQEE--LFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPR 382


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 29.3 bits (64), Expect = 10.0
 Identities = 14/32 (43%), Positives = 23/32 (71%), Gaps = 1/32 (3%)

Query: 100  QSPLDYQYRQE-ILKLENSGGKKNRRIFTYTD 130
            Q+PL    RQE +++++  GGKK+R +F +TD
Sbjct: 1282 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTD 1313


>gi|66730423 hypothetical protein LOC389384 [Homo sapiens]
          Length = 652

 Score = 29.3 bits (64), Expect = 10.0
 Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)

Query: 208 ADLGPYKKLGYKKYEHVLCTLKVDSNGVITVKPDFTG 244
           ADLGP ++ G +  +H    +KVD  G + V P  TG
Sbjct: 196 ADLGPARR-GGEDSDHQSFLIKVDGTGALDVSPHATG 231


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,858,047
Number of Sequences: 37866
Number of extensions: 1007388
Number of successful extensions: 2748
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2731
Number of HSP's gapped (non-prelim): 20
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.