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Search of human proteins with 8923754
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923754 serine/threonine kinase 32B [Homo sapiens]
(414 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923754 serine/threonine kinase 32B [Homo sapiens] 862 0.0
gi|32455269 serine/threonine kinase 32C [Homo sapiens] 562 e-160
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens] 556 e-158
gi|21450709 serine/threonine kinase 32A isoform 2 [Homo sapiens] 293 3e-79
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 194 9e-50
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 191 8e-49
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 191 8e-49
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 190 2e-48
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 190 2e-48
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 190 2e-48
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 188 7e-48
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 187 1e-47
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 187 1e-47
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 183 2e-46
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 183 2e-46
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 183 3e-46
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 183 3e-46
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 182 4e-46
gi|4502023 AKT2 kinase [Homo sapiens] 182 5e-46
gi|133908623 protein kinase C, iota [Homo sapiens] 181 1e-45
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 180 2e-45
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 180 2e-45
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 179 3e-45
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 179 3e-45
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 179 3e-45
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 179 3e-45
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 179 3e-45
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 179 4e-45
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 179 4e-45
gi|47157325 protein kinase C, delta [Homo sapiens] 179 5e-45
>gi|8923754 serine/threonine kinase 32B [Homo sapiens]
Length = 414
Score = 862 bits (2227), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI 60
MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI
Sbjct: 1 MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI 60
Query: 61 ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE 120
ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE
Sbjct: 61 ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE 120
Query: 121 GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSM 180
GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSM
Sbjct: 121 GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSM 180
Query: 181 AGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMF 240
AGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMF
Sbjct: 181 AGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMF 240
Query: 241 KVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGF 300
KVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGF
Sbjct: 241 KVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGF 300
Query: 301 VPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVRE 360
VPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVRE
Sbjct: 301 VPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVRE 360
Query: 361 EFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNLLTHTCTRGCSS 414
EFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNLLTHTCTRGCSS
Sbjct: 361 EFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNLLTHTCTRGCSS 414
>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
Length = 486
Score = 562 bits (1449), Expect = e-160
Identities = 262/366 (71%), Positives = 315/366 (86%), Gaps = 1/366 (0%)
Query: 10 PVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVF 69
PVFD+ E+VNFDHFQILRAIGKGSFGKVCIVQKRDT+KMYAMKYMNKQ+CIERDEVRNVF
Sbjct: 80 PVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVF 139
Query: 70 RELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICE 129
REL+I+Q +EH FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV F+E TV+LYICE
Sbjct: 140 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 199
Query: 130 LALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAP 189
+ALAL+YL+ HIIHRD+KPDNILLDE GH H+TDFNIAT++K ERA+++AGTKPYMAP
Sbjct: 200 MALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAP 259
Query: 190 EVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSS 249
E+F +++ G GYS+ VDWWS+G+ AYELLRGWRPY+IHS ++ ++ +F V Y
Sbjct: 260 EIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVP 319
Query: 250 TWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNC 309
TW K MVALLRKLLT +PE R+SSL D+Q+ P LA + WD + +K + PGFVPNKGRL+C
Sbjct: 320 TWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHC 379
Query: 310 DPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPL-NGHLQHCLETVREEFIIFNRE 368
DPTFELEEMILES+PLHKKKKRLAKN+SRD ++DS N +LQ CL+ ++++F+IFNRE
Sbjct: 380 DPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNRE 439
Query: 369 KLRRQQ 374
KL+R Q
Sbjct: 440 KLKRSQ 445
>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
Length = 396
Score = 556 bits (1432), Expect = e-158
Identities = 277/403 (68%), Positives = 320/403 (79%), Gaps = 7/403 (1%)
Query: 1 MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI 60
MG N S KPPVFDENE+VNFDHF+ILRAIGKGSFGKVCIVQK DTKKMYAMKYMNKQKC+
Sbjct: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
Query: 61 ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE 120
ER+EVRNVF+ELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHF E
Sbjct: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
Query: 121 GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSM 180
TVKL+ICEL +AL+YLQ IIHRD+KPDNILLDEHGHVHITDFNIA ++ + ++M
Sbjct: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM 180
Query: 181 AGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMF 240
AGTKPYMAPE+F +G GYS+ VDWWSLG+TAYELLRG RPY I S T EI++ F
Sbjct: 181 AGTKPYMAPEMFS--SRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTF 238
Query: 241 KVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGF 300
+ V Y S W + MV+LL+KLL +P+ R S L D+Q+ PY+ D+NWDAVF+K L+PGF
Sbjct: 239 ETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGF 298
Query: 301 VPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVRE 360
+PNKGRLNCDPTFELEEMILESKPLHKKKKRLAK + +D K LQ L++V++
Sbjct: 299 IPNKGRLNCDPTFELEEMILESKPLHKKKKRLAK-KEKDMRKCDSSQTCLLQEHLDSVQK 357
Query: 361 EFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNL 403
EFIIFNREK+ R + L + Q +DG NNNL
Sbjct: 358 EFIIFNREKVNRDFNKRQPNLALEQTKDPQG----EDGQNNNL 396
>gi|21450709 serine/threonine kinase 32A isoform 2 [Homo sapiens]
Length = 166
Score = 293 bits (749), Expect = 3e-79
Identities = 138/157 (87%), Positives = 147/157 (93%)
Query: 1 MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI 60
MG N S KPPVFDENE+VNFDHF+ILRAIGKGSFGKVCIVQK DTKKMYAMKYMNKQKC+
Sbjct: 1 MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCV 60
Query: 61 ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE 120
ER+EVRNVF+ELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHF E
Sbjct: 61 ERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKE 120
Query: 121 GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEH 157
TVKL+ICEL +AL+YLQ IIHRD+KPDNILLDEH
Sbjct: 121 ETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEH 157
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 194 bits (494), Expect = 9e-50
Identities = 110/297 (37%), Positives = 175/297 (58%), Gaps = 15/297 (5%)
Query: 16 EEVNFDHFQILRAIGKGSFGKVCIVQKR---DTKKMYAMKYMNKQKCIERDEVRNVFREL 72
E+ + F++L+ +G+GSFGKV +V+K+ D ++YAMK + K RD VR E
Sbjct: 66 EKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-ER 124
Query: 73 QIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELAL 132
I+ + HPF+V L Y+FQ E +++++D L GGD+ L + V FTE VK Y+ ELAL
Sbjct: 125 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELAL 184
Query: 133 ALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIA-TVVKGAERASSMAGTKPYMAPEV 191
AL++L + I++RD+KP+NILLDE GH+ +TDF ++ V ++A S GT YMAPEV
Sbjct: 185 ALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEV 244
Query: 192 FQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTW 251
G+S DWWS G+ +E+L G P++ +E +NM ++
Sbjct: 245 V-----NRRGHSQSADWWSYGVLMFEMLTGTLPFQ---GKDRNETMNMILKAKLGMPQFL 296
Query: 252 CKGMVALLRKLLTKDPESRVSS--LHDIQSVPYLADMNWDAVFKKALMPGFVPNKGR 306
+LLR L ++P +R+ S + +I+ + A+++WD ++K+ + P F P G+
Sbjct: 297 SAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
Score = 82.8 bits (203), Expect = 5e-16
Identities = 72/262 (27%), Positives = 120/262 (45%), Gaps = 24/262 (9%)
Query: 23 FQILRAIGKGSFG--KVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEH 80
+++ IG GS+ K CI T +A+K ++K K +E+ + R Q H
Sbjct: 426 YELKEDIGVGSYSVCKRCI--HATTNMEFAVKIIDKSKRDPSEEIEILMRYGQ------H 477
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRY 140
P ++ L F D +++V DL+ GG+L + + F+E + ++ ++YL
Sbjct: 478 PNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ 537
Query: 141 HIIHRDIKPDNIL-LDEHG---HVHITDFNIATVVKGAE-RASSMAGTKPYMAPEVFQVY 195
++HRD+KP NIL +DE + I DF A ++G + T ++APEV
Sbjct: 538 GVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLM-- 595
Query: 196 MDRGPGYSYPVDWWSLGITAYELLRGWRPY-EIHSVTPIDEILNMFKVERVHYSSTW--- 251
GY D WSLG+ Y +L G+ P+ + TP + +L + + W
Sbjct: 596 ---QQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNI 652
Query: 252 CKGMVALLRKLLTKDPESRVSS 273
G LL +L DP R ++
Sbjct: 653 SDGAKDLLSHMLHMDPHQRYTA 674
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 191 bits (486), Expect = 8e-49
Identities = 112/310 (36%), Positives = 176/310 (56%), Gaps = 21/310 (6%)
Query: 16 EEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRNVFREL 72
E+ + F++L+ +G+GS+GKV +V+K D ++YAMK + K RD VR+ E
Sbjct: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ER 118
Query: 73 QIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELAL 132
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V FTE VK Y+ ELAL
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 133 ALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIA-TVVKGAERASSMAGTKPYMAPEV 191
AL++L II+RD+KP+NILLDE GH+ ITDF ++ + +RA S GT YMAPEV
Sbjct: 179 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 238
Query: 192 FQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTW 251
G++ DWWS G+ +E+L G P++ ++ K+ + S
Sbjct: 239 V-----NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGE 293
Query: 252 CKGMVALLRKLLTKDPESR----VSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGR- 306
+ +LLR L ++P +R + + +I+ P+ ++W+ +++K + P F P GR
Sbjct: 294 AQ---SLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRP 350
Query: 307 ---LNCDPTF 313
+ DP F
Sbjct: 351 EDTFHFDPEF 360
Score = 95.9 bits (237), Expect = 6e-20
Identities = 79/285 (27%), Positives = 135/285 (47%), Gaps = 30/285 (10%)
Query: 7 HKPPVFD-----ENEEVNF-DHFQILRAIGKGSFG--KVCIVQKRDTKKMYAMKYMNKQK 58
HK PV ++F D ++I IG GS+ K C+ + DT+ YA+K ++K K
Sbjct: 401 HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTE--YAVKIIDKSK 458
Query: 59 CIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHF 118
+E+ + R Q HP ++ L + D + +++V++L+ GG+L + + +F
Sbjct: 459 RDPSEEIEILLRYGQ------HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYF 512
Query: 119 TEGTVKLYICELALALEYLQRYHIIHRDIKPDNILL-DEHG---HVHITDFNIATVVK-G 173
+E +C + ++YL ++HRD+KP NIL DE G + + DF A ++ G
Sbjct: 513 SEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG 572
Query: 174 AERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPI 233
+ T ++APEV + GY D WSLGI Y +L G+ P+
Sbjct: 573 NGLLMTPCYTANFVAPEVL-----KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTP 627
Query: 234 DEILNMFKVERVHYS-STW---CKGMVALLRKLLTKDPESRVSSL 274
+EIL + S W ++ K+L DP R++++
Sbjct: 628 EEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAM 672
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 191 bits (486), Expect = 8e-49
Identities = 112/310 (36%), Positives = 176/310 (56%), Gaps = 21/310 (6%)
Query: 16 EEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRNVFREL 72
E+ + F++L+ +G+GS+GKV +V+K D ++YAMK + K RD VR+ E
Sbjct: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ER 110
Query: 73 QIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELAL 132
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V FTE VK Y+ ELAL
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170
Query: 133 ALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIA-TVVKGAERASSMAGTKPYMAPEV 191
AL++L II+RD+KP+NILLDE GH+ ITDF ++ + +RA S GT YMAPEV
Sbjct: 171 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 230
Query: 192 FQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTW 251
G++ DWWS G+ +E+L G P++ ++ K+ + S
Sbjct: 231 V-----NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGE 285
Query: 252 CKGMVALLRKLLTKDPESR----VSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGR- 306
+ +LLR L ++P +R + + +I+ P+ ++W+ +++K + P F P GR
Sbjct: 286 AQ---SLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRP 342
Query: 307 ---LNCDPTF 313
+ DP F
Sbjct: 343 EDTFHFDPEF 352
Score = 95.9 bits (237), Expect = 6e-20
Identities = 79/285 (27%), Positives = 135/285 (47%), Gaps = 30/285 (10%)
Query: 7 HKPPVFD-----ENEEVNF-DHFQILRAIGKGSFG--KVCIVQKRDTKKMYAMKYMNKQK 58
HK PV ++F D ++I IG GS+ K C+ + DT+ YA+K ++K K
Sbjct: 393 HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTE--YAVKIIDKSK 450
Query: 59 CIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHF 118
+E+ + R Q HP ++ L + D + +++V++L+ GG+L + + +F
Sbjct: 451 RDPSEEIEILLRYGQ------HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYF 504
Query: 119 TEGTVKLYICELALALEYLQRYHIIHRDIKPDNILL-DEHG---HVHITDFNIATVVK-G 173
+E +C + ++YL ++HRD+KP NIL DE G + + DF A ++ G
Sbjct: 505 SEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG 564
Query: 174 AERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPI 233
+ T ++APEV + GY D WSLGI Y +L G+ P+
Sbjct: 565 NGLLMTPCYTANFVAPEVL-----KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTP 619
Query: 234 DEILNMFKVERVHYS-STW---CKGMVALLRKLLTKDPESRVSSL 274
+EIL + S W ++ K+L DP R++++
Sbjct: 620 EEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAM 664
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 190 bits (483), Expect = 2e-48
Identities = 102/286 (35%), Positives = 169/286 (59%), Gaps = 14/286 (4%)
Query: 21 DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEH 80
D F+ LR +G GSFG+V +V+ ++T YAMK +NKQK ++ +V ++ E +I+Q ++
Sbjct: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRY 140
PFLV L +SF+D +++V++ + GG++ LQ+ F+E Y ++ LA++YL
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
Query: 141 HIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
+IHRD+KP+N+L+D+ G++ +TDF A VKG R ++ GT Y+APE+
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG--RTWTLCGTPEYLAPEII-----LSK 214
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLR 260
GY+ VDWW+LG+ YE+ G+ P+ ++ PI +I RV + S + LLR
Sbjct: 215 GYNKAVDWWALGVLIYEMAVGFPPF--YADQPI-QIYEKIVSGRVRFPSKLSSDLKHLLR 271
Query: 261 KLLTKDPESRVSSLH----DIQSVPYLADMNWDAVFKKALMPGFVP 302
LL D R +L DI++ + A +W A+++K + F+P
Sbjct: 272 SLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIP 317
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 190 bits (482), Expect = 2e-48
Identities = 107/296 (36%), Positives = 172/296 (58%), Gaps = 17/296 (5%)
Query: 15 NEEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRNVFRE 71
+E+ + HF++L+ +G+GSFGKV +V+K D+ +YAMK + K RD VR E
Sbjct: 63 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-E 121
Query: 72 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELA 131
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V FTE VK Y+ ELA
Sbjct: 122 RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 181
Query: 132 LALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIA-TVVKGAERASSMAGTKPYMAPE 190
L L++L II+RD+KP+NILLDE GH+ +TDF ++ + ++A S GT YMAPE
Sbjct: 182 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 241
Query: 191 VFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSST 250
V G+S+ DWWS G+ +E+L G P++ ++ K+ + ST
Sbjct: 242 VV-----NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLST 296
Query: 251 WCKGMVALLRKLLTKDPESRVSS----LHDIQSVPYLADMNWDAVFKKALMPGFVP 302
+ +LLR L ++P +R+ S +I+ + + ++W+ ++++ + P F P
Sbjct: 297 EAQ---SLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 349
Score = 94.4 bits (233), Expect = 2e-19
Identities = 75/268 (27%), Positives = 126/268 (47%), Gaps = 22/268 (8%)
Query: 21 DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEH 80
D + + IG GS+ + + T YA+K ++K K +E+ + R Q H
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQ------H 478
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRY 140
P ++ L + D + +++V +L+ GG+L + + F+E + + +EYL
Sbjct: 479 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ 538
Query: 141 HIIHRDIKPDNIL-LDEHGH---VHITDFNIATVVKGAERASSMAG--TKPYMAPEVFQV 194
++HRD+KP NIL +DE G+ + I DF A ++ AE M T ++APEV
Sbjct: 539 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLR-AENGLLMTPCYTANFVAPEVL-- 595
Query: 195 YMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYS----ST 250
+ GY D WSLGI Y +L G+ P+ +EIL + S +T
Sbjct: 596 ---KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 652
Query: 251 WCKGMVALLRKLLTKDPESRVSSLHDIQ 278
+ L+ K+L DP R+++ +Q
Sbjct: 653 VSETAKDLVSKMLHVDPHQRLTAKQVLQ 680
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 190 bits (482), Expect = 2e-48
Identities = 107/296 (36%), Positives = 172/296 (58%), Gaps = 17/296 (5%)
Query: 15 NEEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRNVFRE 71
+E+ + HF++L+ +G+GSFGKV +V+K D+ +YAMK + K RD VR E
Sbjct: 54 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-E 112
Query: 72 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELA 131
I+ + HPF+V L Y+FQ E +++++D L GGDL L + V FTE VK Y+ ELA
Sbjct: 113 RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 172
Query: 132 LALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIA-TVVKGAERASSMAGTKPYMAPE 190
L L++L II+RD+KP+NILLDE GH+ +TDF ++ + ++A S GT YMAPE
Sbjct: 173 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 232
Query: 191 VFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSST 250
V G+S+ DWWS G+ +E+L G P++ ++ K+ + ST
Sbjct: 233 VV-----NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLST 287
Query: 251 WCKGMVALLRKLLTKDPESRVSS----LHDIQSVPYLADMNWDAVFKKALMPGFVP 302
+ +LLR L ++P +R+ S +I+ + + ++W+ ++++ + P F P
Sbjct: 288 EAQ---SLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 340
Score = 94.4 bits (233), Expect = 2e-19
Identities = 75/268 (27%), Positives = 126/268 (47%), Gaps = 22/268 (8%)
Query: 21 DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEH 80
D + + IG GS+ + + T YA+K ++K K +E+ + R Q H
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQ------H 469
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRY 140
P ++ L + D + +++V +L+ GG+L + + F+E + + +EYL
Sbjct: 470 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ 529
Query: 141 HIIHRDIKPDNIL-LDEHGH---VHITDFNIATVVKGAERASSMAG--TKPYMAPEVFQV 194
++HRD+KP NIL +DE G+ + I DF A ++ AE M T ++APEV
Sbjct: 530 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLR-AENGLLMTPCYTANFVAPEVL-- 586
Query: 195 YMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYS----ST 250
+ GY D WSLGI Y +L G+ P+ +EIL + S +T
Sbjct: 587 ---KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 643
Query: 251 WCKGMVALLRKLLTKDPESRVSSLHDIQ 278
+ L+ K+L DP R+++ +Q
Sbjct: 644 VSETAKDLVSKMLHVDPHQRLTAKQVLQ 671
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 188 bits (478), Expect = 7e-48
Identities = 107/304 (35%), Positives = 174/304 (57%), Gaps = 17/304 (5%)
Query: 11 VFDENEEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRN 67
V + +E+ + F++L+ +G+GSFGKV +V+K D +++YAMK + K RD VR
Sbjct: 56 VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRT 115
Query: 68 VFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYI 127
E I+ + HPF+V L Y+FQ E +++++D L GGDL L + V FTE VK Y+
Sbjct: 116 KM-ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 174
Query: 128 CELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIA-TVVKGAERASSMAGTKPY 186
ELALAL++L II+RD+KP+NILLDE GH+ +TDF ++ + ++A S GT Y
Sbjct: 175 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEY 234
Query: 187 MAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVH 246
MAPEV G++ DWWS G+ +E+L G P++ E + M ++
Sbjct: 235 MAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGTLPFQ---GKDRKETMTMILKAKLG 286
Query: 247 YSSTWCKGMVALLRKLLTKDPESRVSS----LHDIQSVPYLADMNWDAVFKKALMPGFVP 302
+LLR L ++P +R+ + + +I+ + + ++W+ ++++ + P F P
Sbjct: 287 MPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 346
Query: 303 NKGR 306
GR
Sbjct: 347 ATGR 350
Score = 90.5 bits (223), Expect = 3e-18
Identities = 74/265 (27%), Positives = 126/265 (47%), Gaps = 26/265 (9%)
Query: 21 DHFQILRAIGKGSFG--KVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGL 78
D +++ IG GS+ K CI + T +A+K ++K K +E+ + R Q
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCI--HKATNMEFAVKIIDKSKRDPTEEIEILLRYGQ----- 472
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQ 138
HP ++ L + D + +++V +L+ GG+L + + F+E + + +EYL
Sbjct: 473 -HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
Query: 139 RYHIIHRDIKPDNIL-LDEHGH---VHITDFNIATVVKGAERASSMAG--TKPYMAPEVF 192
++HRD+KP NIL +DE G+ + I DF A ++ AE M T ++APEV
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLR-AENGLLMTPCYTANFVAPEVL 590
Query: 193 QVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWC 252
+ GY D WSLG+ Y +L G+ P+ +EIL + S +
Sbjct: 591 -----KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW 645
Query: 253 KGM----VALLRKLLTKDPESRVSS 273
+ L+ K+L DP R+++
Sbjct: 646 NSVSDTAKDLVSKMLHVDPHQRLTA 670
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 187 bits (476), Expect = 1e-47
Identities = 96/288 (33%), Positives = 170/288 (59%), Gaps = 14/288 (4%)
Query: 19 NFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGL 78
+ D F+ ++ +G GSFG+V +V+ ++T YAMK ++KQK ++ ++ + E +I+Q +
Sbjct: 32 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 91
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQ 138
PFLV L +SF+D +++MV++ + GG++ HL++ F+E + Y ++ L EYL
Sbjct: 92 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 151
Query: 139 RYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDR 198
+I+RD+KP+N+L+D+ G++ +TDF A VKG R ++ GT Y+APE+
Sbjct: 152 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEII-----L 204
Query: 199 GPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVAL 258
GY+ VDWW+LG+ YE+ G+ P+ + PI +I +V + S + + L
Sbjct: 205 SKGYNKAVDWWALGVLIYEMAAGYPPF--FADQPI-QIYEKIVSGKVRFPSHFSSDLKDL 261
Query: 259 LRKLLTKDPESRVSSL----HDIQSVPYLADMNWDAVFKKALMPGFVP 302
LR LL D R +L +DI++ + A +W A++++ + F+P
Sbjct: 262 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 309
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 187 bits (476), Expect = 1e-47
Identities = 96/288 (33%), Positives = 170/288 (59%), Gaps = 14/288 (4%)
Query: 19 NFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGL 78
+ D F+ ++ +G GSFG+V +V+ ++T YAMK ++KQK ++ ++ + E +I+Q +
Sbjct: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 99
Query: 79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQ 138
PFLV L +SF+D +++MV++ + GG++ HL++ F+E + Y ++ L EYL
Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
Query: 139 RYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDR 198
+I+RD+KP+N+L+D+ G++ +TDF A VKG R ++ GT Y+APE+
Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEII-----L 212
Query: 199 GPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVAL 258
GY+ VDWW+LG+ YE+ G+ P+ + PI +I +V + S + + L
Sbjct: 213 SKGYNKAVDWWALGVLIYEMAAGYPPF--FADQPI-QIYEKIVSGKVRFPSHFSSDLKDL 269
Query: 259 LRKLLTKDPESRVSSL----HDIQSVPYLADMNWDAVFKKALMPGFVP 302
LR LL D R +L +DI++ + A +W A++++ + F+P
Sbjct: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 183 bits (465), Expect = 2e-46
Identities = 107/288 (37%), Positives = 163/288 (56%), Gaps = 17/288 (5%)
Query: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIM-QGLEHP 81
F L+ IGKGSFGKV + +++ K YA+K + K+ + R E +++ E ++ + ++HP
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYH 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + Y E+A AL YL
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 142 IIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
I++RD+KP+NILLD GHV +TDF + + ++ ++ GT Y+APEV R
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVI-----RKQ 336
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPI-DEILNMFKVERVHYSST-WCKGMVAL 258
Y VDWW LG YE+L G P+ V + D IL+ R S T W ++
Sbjct: 337 PYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW-----SI 391
Query: 259 LRKLLTKDPESRVSSLHD---IQSVPYLADMNWDAVFKKALMPGFVPN 303
L +LL KD ++R+ + D IQ+ P+ ++W + +K + P F PN
Sbjct: 392 LEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPN 439
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 183 bits (465), Expect = 2e-46
Identities = 107/288 (37%), Positives = 163/288 (56%), Gaps = 17/288 (5%)
Query: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIM-QGLEHP 81
F L+ IGKGSFGKV + +++ K YA+K + K+ + R E +++ E ++ + ++HP
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYH 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + Y E+A AL YL
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 142 IIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
I++RD+KP+NILLD GHV +TDF + + ++ ++ GT Y+APEV R
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVI-----RKQ 336
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPI-DEILNMFKVERVHYSST-WCKGMVAL 258
Y VDWW LG YE+L G P+ V + D IL+ R S T W ++
Sbjct: 337 PYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW-----SI 391
Query: 259 LRKLLTKDPESRVSSLHD---IQSVPYLADMNWDAVFKKALMPGFVPN 303
L +LL KD ++R+ + D IQ+ P+ ++W + +K + P F PN
Sbjct: 392 LEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPN 439
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 183 bits (464), Expect = 3e-46
Identities = 95/286 (33%), Positives = 167/286 (58%), Gaps = 14/286 (4%)
Query: 21 DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEH 80
+ F+ + +G GSFG+V +V+ + T++ YAMK ++KQK ++ ++ + E +I+Q +
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRY 140
PFLV L Y+F+D +++MV++ + GG++ HL++ F+E + Y ++ L EYL
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
Query: 141 HIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
+I+RD+KP+N+L+D G++ +TDF A VKG R ++ GT Y+APE+
Sbjct: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEII-----LSK 214
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLR 260
GY+ VDWW+LG+ YE+ G+ P+ + PI +I +V + S + + LLR
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPF--FADQPI-QIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query: 261 KLLTKDPESRVSSL----HDIQSVPYLADMNWDAVFKKALMPGFVP 302
LL D R +L DI++ + A +W A++++ + F+P
Sbjct: 272 NLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 317
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 183 bits (464), Expect = 3e-46
Identities = 95/286 (33%), Positives = 167/286 (58%), Gaps = 14/286 (4%)
Query: 21 DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEH 80
+ F+ + +G GSFG+V +V+ + T++ YAMK ++KQK ++ ++ + E +I+Q +
Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148
Query: 81 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRY 140
PFLV L Y+F+D +++MV++ + GG++ HL++ F+E + Y ++ L EYL
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208
Query: 141 HIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
+I+RD+KP+N+L+D G++ +TDF A VKG R ++ GT Y+APE+
Sbjct: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEII-----LSK 261
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLR 260
GY+ VDWW+LG+ YE+ G+ P+ + PI +I +V + S + + LLR
Sbjct: 262 GYNKAVDWWALGVLIYEMAAGYPPF--FADQPI-QIYEKIVSGKVRFPSHFSSDLKDLLR 318
Query: 261 KLLTKDPESRVSSL----HDIQSVPYLADMNWDAVFKKALMPGFVP 302
LL D R +L DI++ + A +W A++++ + F+P
Sbjct: 319 NLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 364
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 182 bits (463), Expect = 4e-46
Identities = 104/309 (33%), Positives = 166/309 (53%), Gaps = 14/309 (4%)
Query: 15 NEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQI 74
N + + F + R IG+G FG+V +K DT KMYAMK ++K++ I+ + + +I
Sbjct: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKR-IKMKQGETLALNERI 241
Query: 75 MQGL----EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICEL 130
M L + PF+V + Y+F + + ++DL+ GGDL YHL Q+ F+E ++ Y E+
Sbjct: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301
Query: 131 ALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPE 190
L LE++ +++RD+KP NILLDEHGHV I+D +A ++ + GT YMAPE
Sbjct: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPE 360
Query: 191 VFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSST 250
V Q +G Y DW+SLG ++LLRG P+ H EI M V +
Sbjct: 361 VLQ----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416
Query: 251 WCKGMVALLRKLLTKDPESRVSSL----HDIQSVPYLADMNWDAVFKKALMPGFVPNKGR 306
+ + +LL LL +D R+ L +++ P+ ++W VF + P +P +G
Sbjct: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGE 476
Query: 307 LNCDPTFEL 315
+N F++
Sbjct: 477 VNAADAFDI 485
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 182 bits (462), Expect = 5e-46
Identities = 99/291 (34%), Positives = 157/291 (53%), Gaps = 13/291 (4%)
Query: 17 EVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQ 76
+V + F L+ +GKG+FGKV +V+++ T + YAMK + K+ I +DEV + E +++Q
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
Query: 77 GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEY 136
HPFL L Y+FQ + + V++ GG+L +HL + FTE + Y E+ ALEY
Sbjct: 206 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 265
Query: 137 LQRYHIIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVY 195
L +++RDIK +N++LD+ GH+ ITDF + + + GT Y+APEV +
Sbjct: 266 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE-- 323
Query: 196 MDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGM 255
Y VDWW LG+ YE++ G P+ + E++ M E + + T
Sbjct: 324 ---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM---EEIRFPRTLSPEA 377
Query: 256 VALLRKLLTKDPESRV----SSLHDIQSVPYLADMNWDAVFKKALMPGFVP 302
+LL LL KDP+ R+ S ++ + +NW V +K L+P F P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 181 bits (459), Expect = 1e-45
Identities = 98/302 (32%), Positives = 166/302 (54%), Gaps = 18/302 (5%)
Query: 15 NEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQI 74
+ + F +LR IG+GS+ KV +V+ + T ++YAMK + K+ + +++ V E +
Sbjct: 246 SSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHV 305
Query: 75 M-QGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALA 133
Q HPFLV L FQ E +F V++ + GGDL +H+Q+ E + Y E++LA
Sbjct: 306 FEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 365
Query: 134 LEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVF 192
L YL II+RD+K DN+LLD GH+ +TD+ + ++ + S+ GT Y+APE+
Sbjct: 366 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 425
Query: 193 QVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEI--HSVTP----IDEILNMFKVERVH 246
RG Y + VDWW+LG+ +E++ G P++I S P D + + +++
Sbjct: 426 -----RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 480
Query: 247 YSSTWCKGMVALLRKLLTKDPESRV-----SSLHDIQSVPYLADMNWDAVFKKALMPGFV 301
+ ++L+ L KDP+ R+ + DIQ P+ +++WD + +K ++P F
Sbjct: 481 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 540
Query: 302 PN 303
PN
Sbjct: 541 PN 542
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 180 bits (456), Expect = 2e-45
Identities = 108/299 (36%), Positives = 167/299 (55%), Gaps = 15/299 (5%)
Query: 16 EEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRNVFR-E 71
E+V ++F++L+ +G G++GKV +V+K DT K+YAMK + K +++ + R E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 72 LQIMQGL-EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICEL 130
Q+++ + + PFLV L Y+FQ E + +++D + GG+L HL Q FTE V++Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 131 ALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIAT--VVKGAERASSMAGTKPYMA 188
LALE+L + II+RDIK +NILLD +GHV +TDF ++ V ERA S GT YMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 189 PEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPID-EILNMFKVERVHY 247
P++ + G+ VDWWSLG+ YELL G P+ + EI Y
Sbjct: 222 PDIVR---GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY 278
Query: 248 SSTWCKGMVALLRKLLTKDPESRVS----SLHDIQSVPYLADMNWDAVFKKALMPGFVP 302
L+++LL KDP+ R+ +I+ + +NWD + K + F P
Sbjct: 279 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 337
Score = 58.2 bits (139), Expect = 1e-08
Identities = 35/126 (27%), Positives = 74/126 (58%), Gaps = 9/126 (7%)
Query: 27 RAIGKGSFG--KVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLV 84
+ +G+GSF + C+ +K + + +A+K ++K+ +E + + + L++ +G HP +V
Sbjct: 430 KPLGEGSFSICRKCVHKK--SNQAFAVKIISKR--MEANTQKEI-TALKLCEG--HPNIV 482
Query: 85 NLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIH 144
L F D+ F+V++LL GG+L +++ HF+E + +L A+ ++ ++H
Sbjct: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
Query: 145 RDIKPD 150
RD+KP+
Sbjct: 543 RDLKPE 548
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 180 bits (456), Expect = 2e-45
Identities = 108/299 (36%), Positives = 167/299 (55%), Gaps = 15/299 (5%)
Query: 16 EEVNFDHFQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCIERDEVRNVFR-E 71
E+V ++F++L+ +G G++GKV +V+K DT K+YAMK + K +++ + R E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 72 LQIMQGL-EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICEL 130
Q+++ + + PFLV L Y+FQ E + +++D + GG+L HL Q FTE V++Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 131 ALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIAT--VVKGAERASSMAGTKPYMA 188
LALE+L + II+RDIK +NILLD +GHV +TDF ++ V ERA S GT YMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 189 PEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPID-EILNMFKVERVHY 247
P++ + G+ VDWWSLG+ YELL G P+ + EI Y
Sbjct: 222 PDIVR---GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY 278
Query: 248 SSTWCKGMVALLRKLLTKDPESRVS----SLHDIQSVPYLADMNWDAVFKKALMPGFVP 302
L+++LL KDP+ R+ +I+ + +NWD + K + F P
Sbjct: 279 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 337
Score = 91.3 bits (225), Expect = 1e-18
Identities = 71/259 (27%), Positives = 131/259 (50%), Gaps = 26/259 (10%)
Query: 27 RAIGKGSFG--KVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLV 84
+ +G+GSF + C+ +K + + +A+K ++K+ +E + + + L++ +G HP +V
Sbjct: 430 KPLGEGSFSICRKCVHKK--SNQAFAVKIISKR--MEANTQKEI-TALKLCEG--HPNIV 482
Query: 85 NLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIH 144
L F D+ F+V++LL GG+L +++ HF+E + +L A+ ++ ++H
Sbjct: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
Query: 145 RDIKPDNILLDEHG---HVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
RD+KP+N+L + + I DF A + + + T Y APE+
Sbjct: 543 RDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-----NQN 597
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIH--SVTPIDEILNMFKVERVHYS---STW---C 252
GY D WSLG+ Y +L G P++ H S+T + M K+++ +S W
Sbjct: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 657
Query: 253 KGMVALLRKLLTKDPESRV 271
+ L++ LLT DP R+
Sbjct: 658 QEAKDLIQGLLTVDPNKRL 676
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 179 bits (455), Expect = 3e-45
Identities = 97/285 (34%), Positives = 157/285 (55%), Gaps = 13/285 (4%)
Query: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPF 82
F L+ +GKG+FGKV +V+++ + K YAMK + K+ I +DEV + E ++++ HPF
Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207
Query: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHI 142
L +L YSFQ ++ + V++ + GG+L +HL + F+E + Y E+ AL+YL I
Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267
Query: 143 IHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGPG 201
++RD+K +N++LD+ GH+ ITDF + + A + GT Y+APEV +
Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLE-----DND 322
Query: 202 YSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRK 261
Y VDWW LG+ YE++ G P+ + E++ M E + + T +LL
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM---EDIKFPRTLSSDAKSLLSG 379
Query: 262 LLTKDPESRV----SSLHDIQSVPYLADMNWDAVFKKALMPGFVP 302
LL KDP R+ +I + + +NW V+ K L+P F P
Sbjct: 380 LLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 179 bits (455), Expect = 3e-45
Identities = 97/285 (34%), Positives = 157/285 (55%), Gaps = 13/285 (4%)
Query: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPF 82
F L+ +GKG+FGKV +V+++ + K YAMK + K+ I +DEV + E ++++ HPF
Sbjct: 148 FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF 207
Query: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHI 142
L +L YSFQ ++ + V++ + GG+L +HL + F+E + Y E+ AL+YL I
Sbjct: 208 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI 267
Query: 143 IHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGPG 201
++RD+K +N++LD+ GH+ ITDF + + A + GT Y+APEV +
Sbjct: 268 VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLE-----DND 322
Query: 202 YSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRK 261
Y VDWW LG+ YE++ G P+ + E++ M E + + T +LL
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM---EDIKFPRTLSSDAKSLLSG 379
Query: 262 LLTKDPESRV----SSLHDIQSVPYLADMNWDAVFKKALMPGFVP 302
LL KDP R+ +I + + +NW V+ K L+P F P
Sbjct: 380 LLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 179 bits (455), Expect = 3e-45
Identities = 99/311 (31%), Positives = 166/311 (53%), Gaps = 12/311 (3%)
Query: 14 ENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQ 73
E + V + F+ R +GKG FG+VC Q R T KMYA K + K++ +R E +
Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 237
Query: 74 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFTEGTVKLYICELA 131
I++ ++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E Y EL
Sbjct: 238 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 297
Query: 132 LALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEV 191
LE LQR I++RD+KP+NILLD+ GH+ I+D +AT + +R GT YMAPEV
Sbjct: 298 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 357
Query: 192 FQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIH-SVTPIDEILNMFKVERVHYSST 250
Y++ DWW LG YE+++G P++ + +E+ K + YS
Sbjct: 358 V-----NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
Query: 251 WCKGMVALLRKLLTKDPESRVSSLHD----IQSVPYLADMNWDAVFKKALMPGFVPNKGR 306
+ + ++ R LLTK+P R+ + ++ P D+N+ + L P F P+
Sbjct: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 472
Query: 307 LNCDPTFELEE 317
+ C ++E+
Sbjct: 473 VYCKDVLDIEQ 483
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 179 bits (455), Expect = 3e-45
Identities = 99/311 (31%), Positives = 166/311 (53%), Gaps = 12/311 (3%)
Query: 14 ENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQ 73
E + V + F+ R +GKG FG+VC Q R T KMYA K + K++ +R E +
Sbjct: 146 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 205
Query: 74 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFTEGTVKLYICELA 131
I++ ++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E Y EL
Sbjct: 206 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 265
Query: 132 LALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEV 191
LE LQR I++RD+KP+NILLD+ GH+ I+D +AT + +R GT YMAPEV
Sbjct: 266 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 325
Query: 192 FQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIH-SVTPIDEILNMFKVERVHYSST 250
Y++ DWW LG YE+++G P++ + +E+ K + YS
Sbjct: 326 V-----NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 380
Query: 251 WCKGMVALLRKLLTKDPESRVSSLHD----IQSVPYLADMNWDAVFKKALMPGFVPNKGR 306
+ + ++ R LLTK+P R+ + ++ P D+N+ + L P F P+
Sbjct: 381 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 440
Query: 307 LNCDPTFELEE 317
+ C ++E+
Sbjct: 441 VYCKDVLDIEQ 451
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 179 bits (455), Expect = 3e-45
Identities = 99/311 (31%), Positives = 166/311 (53%), Gaps = 12/311 (3%)
Query: 14 ENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQ 73
E + V + F+ R +GKG FG+VC Q R T KMYA K + K++ +R E +
Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 237
Query: 74 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFTEGTVKLYICELA 131
I++ ++ F+V+L Y+++ ++ + +V+ ++ GGDL++H+ N F E Y EL
Sbjct: 238 ILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELC 297
Query: 132 LALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEV 191
LE LQR I++RD+KP+NILLD+ GH+ I+D +AT + +R GT YMAPEV
Sbjct: 298 CGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 357
Query: 192 FQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIH-SVTPIDEILNMFKVERVHYSST 250
Y++ DWW LG YE+++G P++ + +E+ K + YS
Sbjct: 358 V-----NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
Query: 251 WCKGMVALLRKLLTKDPESRVSSLHD----IQSVPYLADMNWDAVFKKALMPGFVPNKGR 306
+ + ++ R LLTK+P R+ + ++ P D+N+ + L P F P+
Sbjct: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 472
Query: 307 LNCDPTFELEE 317
+ C ++E+
Sbjct: 473 VYCKDVLDIEQ 483
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 179 bits (454), Expect = 4e-45
Identities = 103/287 (35%), Positives = 159/287 (55%), Gaps = 15/287 (5%)
Query: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIM-QGLEHP 81
F L+ IGKG++GKV + +++ YA+K + K+ +++ E ++ E ++ + + HP
Sbjct: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYH 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + Y E+A A+ YL +
Sbjct: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154
Query: 142 IIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
II+RD+KP+NILLD GHV +TDF + V+ + S+ GT Y+APEV R
Sbjct: 155 IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL-----RKE 209
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPI-DEILNMFKVERVHYSSTWCKGMVALL 259
Y VDWW LG YE+L G P+ V+ + + IL+ + + LL
Sbjct: 210 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH----QPLQIPGGRTVAACDLL 265
Query: 260 RKLLTKDPESRVSSLHD---IQSVPYLADMNWDAVFKKALMPGFVPN 303
+ LL KD R+ S D I++ + + +NWD ++ K L P F PN
Sbjct: 266 QSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPN 312
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 179 bits (454), Expect = 4e-45
Identities = 103/287 (35%), Positives = 159/287 (55%), Gaps = 15/287 (5%)
Query: 23 FQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIM-QGLEHP 81
F L+ IGKG++GKV + +++ YA+K + K+ +++ E ++ E ++ + + HP
Sbjct: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
Query: 82 FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYH 141
FLV L YSFQ E ++ V+D + GG+L +HLQ+ F E + Y E+A A+ YL +
Sbjct: 155 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 214
Query: 142 IIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMAPEVFQVYMDRGP 200
II+RD+KP+NILLD GHV +TDF + V+ + S+ GT Y+APEV R
Sbjct: 215 IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL-----RKE 269
Query: 201 GYSYPVDWWSLGITAYELLRGWRPYEIHSVTPI-DEILNMFKVERVHYSSTWCKGMVALL 259
Y VDWW LG YE+L G P+ V+ + + IL+ + + LL
Sbjct: 270 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH----QPLQIPGGRTVAACDLL 325
Query: 260 RKLLTKDPESRVSSLHD---IQSVPYLADMNWDAVFKKALMPGFVPN 303
+ LL KD R+ S D I++ + + +NWD ++ K L P F PN
Sbjct: 326 QSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPN 372
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 179 bits (453), Expect = 5e-45
Identities = 107/348 (30%), Positives = 174/348 (50%), Gaps = 11/348 (3%)
Query: 11 VFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFR 70
+++ + + N ++F + +GKGSFGKV + + + + +A+K + K + D+V
Sbjct: 337 IWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMV 396
Query: 71 ELQIMQ-GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICE 129
E +++ E+PFL +L +FQ ++ +F V++ L GGDL YH+Q F Y E
Sbjct: 397 EKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAE 456
Query: 130 LALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATV-VKGAERASSMAGTKPYMA 188
+ L++L II+RD+K DN+LLD GH+ I DF + + G RAS+ GT Y+A
Sbjct: 457 IMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIA 516
Query: 189 PEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYS 248
PE+ Q G Y++ VDWWS G+ YE+L G P+ DE+ +V+ HY
Sbjct: 517 PEILQ-----GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDE---DELFESIRVDTPHYP 568
Query: 249 STWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLN 308
K +L KL ++P R+ +I+ P+ +NW + K+ L P F P
Sbjct: 569 RWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
Query: 309 CDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLE 356
F+ +E + E L K L + + +N +H LE
Sbjct: 629 DYSNFD-QEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLE 675
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,566,703
Number of Sequences: 37866
Number of extensions: 737827
Number of successful extensions: 3876
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 682
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 1631
Number of HSP's gapped (non-prelim): 930
length of query: 414
length of database: 18,247,518
effective HSP length: 105
effective length of query: 309
effective length of database: 14,271,588
effective search space: 4409920692
effective search space used: 4409920692
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.