BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|14149946 protein kinase-like protein SgK196 [Homo sapiens] (350 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|14149946 protein kinase-like protein SgK196 [Homo sapiens] 722 0.0 gi|148596974 TXK tyrosine kinase [Homo sapiens] 53 4e-07 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 47 3e-05 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 47 3e-05 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 47 3e-05 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 47 3e-05 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 47 3e-05 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 44 2e-04 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 44 2e-04 gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 44 2e-04 gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 44 2e-04 gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 44 2e-04 gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 44 2e-04 gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 43 4e-04 gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 43 4e-04 gi|187475373 c-src tyrosine kinase [Homo sapiens] 42 0.001 gi|4758078 c-src tyrosine kinase [Homo sapiens] 42 0.001 gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 41 0.001 gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 41 0.002 gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 41 0.002 gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 41 0.002 gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 41 0.002 gi|130977759 tec protein tyrosine kinase [Homo sapiens] 40 0.002 gi|29725609 epidermal growth factor receptor isoform a precursor... 40 0.004 gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 40 0.004 gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 40 0.004 gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 39 0.009 gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 39 0.009 gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 39 0.009 gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 39 0.009 >gi|14149946 protein kinase-like protein SgK196 [Homo sapiens] Length = 350 Score = 722 bits (1864), Expect = 0.0 Identities = 350/350 (100%), Positives = 350/350 (100%) Query: 1 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF 60 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF Sbjct: 1 MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF 60 Query: 61 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL 120 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL Sbjct: 61 RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL 120 Query: 121 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE 180 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE Sbjct: 121 HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE 180 Query: 181 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM 240 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM Sbjct: 181 LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM 240 Query: 241 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD 300 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD Sbjct: 241 LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD 300 Query: 301 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML 350 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML Sbjct: 301 MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML 350 >gi|148596974 TXK tyrosine kinase [Homo sapiens] Length = 527 Score = 53.1 bits (126), Expect = 4e-07 Identities = 67/299 (22%), Positives = 125/299 (41%), Gaps = 37/299 (12%) Query: 60 FRIGQMKNCSP------WLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEH-KVALSQLTS 112 + +G M +C P + E +E+ +K +G G V L EW+ H +VA+ + Sbjct: 244 YPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINE 303 Query: 113 LEM-KDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTM--LTEYHPLGSLSNL--EETLNLS 167 M ++DF+ +++ L + +V L G C + +TE+ G L N E L Sbjct: 304 GSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLR 363 Query: 168 KYQNVNTWQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILAND 227 K ++ Q E M+Y+ Y+H + S + K S+F + Sbjct: 364 KEMLLSVCQDICE-GMEYLERNGYIHRDLAARNCLVSSTCIVK-------ISDFGMTRYV 415 Query: 228 LDALPLVNHSSGMLVKCGHRE--LHGDFVAPEQLWPYGEDV--PFHDDLMPSYDEKIDIW 283 LD + + + +K E L + + +W +G + F + MP ++ K ++ Sbjct: 416 LDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMP-FENKSNLQ 474 Query: 284 KIPDISSFLLGHIEGSDMVRFHL-----FDIHKACKSQTPSERPTAQDVLETYQKVLDT 337 + IS EG + R HL +++ +C + P RPT ++L ++ +T Sbjct: 475 VVEAIS-------EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAET 526 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 47.0 bits (110), Expect = 3e-05 Identities = 58/283 (20%), Positives = 118/283 (41%), Gaps = 32/283 (11%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDFLHGLQMLKSLQGTHV 134 RT++ ++G G V++ WK++ + ++ T E ++FL ++K ++ ++ Sbjct: 270 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 329 Query: 135 VTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--WQHRLELAMDYVSIIN 190 V LLG C E ++TEY P G+L + N + V ++ AM+Y+ N Sbjct: 330 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 389 Query: 191 YLHHSPVGTRVMCDSNDLPKTLSQYL--LTSNFSILANDLDALPLVNHSSGMLVKCGHRE 248 ++H + N + K L L + + A+ P+ + L Sbjct: 390 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA------ 443 Query: 249 LHGDFVAPEQLWPYG----EDVPFHDDLMPSYDEKIDIWKIPDI--SSFLLGHIEGSDMV 302 + F +W +G E + P ID+ ++ D+ + + EG Sbjct: 444 -YNTFSIKSDVWAFGVLLWEIATYGMSPYPG----IDLSQVYDLLEKGYRMEQPEGCPP- 497 Query: 303 RFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQ 345 ++++ +AC +P++RP+ ET+Q D+ +S+ Sbjct: 498 --KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISE 535 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 47.0 bits (110), Expect = 3e-05 Identities = 58/283 (20%), Positives = 118/283 (41%), Gaps = 32/283 (11%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDFLHGLQMLKSLQGTHV 134 RT++ ++G G V++ WK++ + ++ T E ++FL ++K ++ ++ Sbjct: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 344 Query: 135 VTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--WQHRLELAMDYVSIIN 190 V LLG C E ++TEY P G+L + N + V ++ AM+Y+ N Sbjct: 345 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 404 Query: 191 YLHHSPVGTRVMCDSNDLPKTLSQYL--LTSNFSILANDLDALPLVNHSSGMLVKCGHRE 248 ++H + N + K L L + + A+ P+ + L Sbjct: 405 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA------ 458 Query: 249 LHGDFVAPEQLWPYG----EDVPFHDDLMPSYDEKIDIWKIPDI--SSFLLGHIEGSDMV 302 + F +W +G E + P ID+ ++ D+ + + EG Sbjct: 459 -YNTFSIKSDVWAFGVLLWEIATYGMSPYPG----IDLSQVYDLLEKGYRMEQPEGCPP- 512 Query: 303 RFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQ 345 ++++ +AC +P++RP+ ET+Q D+ +S+ Sbjct: 513 --KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISE 550 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 47.0 bits (110), Expect = 3e-05 Identities = 58/283 (20%), Positives = 118/283 (41%), Gaps = 32/283 (11%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDFLHGLQMLKSLQGTHV 134 RT++ ++G G V++ WK++ + ++ T E ++FL ++K ++ ++ Sbjct: 264 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 323 Query: 135 VTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--WQHRLELAMDYVSIIN 190 V LLG C E ++TEY P G+L + N + V ++ AM+Y+ N Sbjct: 324 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 383 Query: 191 YLHHSPVGTRVMCDSNDLPKTLSQYL--LTSNFSILANDLDALPLVNHSSGMLVKCGHRE 248 ++H + N + K L L + + A+ P+ + L Sbjct: 384 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA------ 437 Query: 249 LHGDFVAPEQLWPYG----EDVPFHDDLMPSYDEKIDIWKIPDI--SSFLLGHIEGSDMV 302 + F +W +G E + P ID+ ++ D+ + + EG Sbjct: 438 -YNTFSIKSDVWAFGVLLWEIATYGMSPYPG----IDLSQVYDLLEKGYRMEQPEGCPP- 491 Query: 303 RFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQ 345 ++++ +AC +P++RP+ ET+Q D+ +S+ Sbjct: 492 --KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISE 529 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 47.0 bits (110), Expect = 3e-05 Identities = 58/283 (20%), Positives = 118/283 (41%), Gaps = 32/283 (11%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDFLHGLQMLKSLQGTHV 134 RT++ ++G G V++ WK++ + ++ T E ++FL ++K ++ ++ Sbjct: 270 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 329 Query: 135 VTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--WQHRLELAMDYVSIIN 190 V LLG C E ++TEY P G+L + N + V ++ AM+Y+ N Sbjct: 330 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 389 Query: 191 YLHHSPVGTRVMCDSNDLPKTLSQYL--LTSNFSILANDLDALPLVNHSSGMLVKCGHRE 248 ++H + N + K L L + + A+ P+ + L Sbjct: 390 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA------ 443 Query: 249 LHGDFVAPEQLWPYG----EDVPFHDDLMPSYDEKIDIWKIPDI--SSFLLGHIEGSDMV 302 + F +W +G E + P ID+ ++ D+ + + EG Sbjct: 444 -YNTFSIKSDVWAFGVLLWEIATYGMSPYPG----IDLSQVYDLLEKGYRMEQPEGCPP- 497 Query: 303 RFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQ 345 ++++ +AC +P++RP+ ET+Q D+ +S+ Sbjct: 498 --KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISE 535 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 47.0 bits (110), Expect = 3e-05 Identities = 58/283 (20%), Positives = 118/283 (41%), Gaps = 32/283 (11%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDFLHGLQMLKSLQGTHV 134 RT++ ++G G V++ WK++ + ++ T E ++FL ++K ++ ++ Sbjct: 249 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 308 Query: 135 VTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--WQHRLELAMDYVSIIN 190 V LLG C E ++TEY P G+L + N + V ++ AM+Y+ N Sbjct: 309 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 368 Query: 191 YLHHSPVGTRVMCDSNDLPKTLSQYL--LTSNFSILANDLDALPLVNHSSGMLVKCGHRE 248 ++H + N + K L L + + A+ P+ + L Sbjct: 369 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA------ 422 Query: 249 LHGDFVAPEQLWPYG----EDVPFHDDLMPSYDEKIDIWKIPDI--SSFLLGHIEGSDMV 302 + F +W +G E + P ID+ ++ D+ + + EG Sbjct: 423 -YNTFSIKSDVWAFGVLLWEIATYGMSPYPG----IDLSQVYDLLEKGYRMEQPEGCPP- 476 Query: 303 RFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQ 345 ++++ +AC +P++RP+ ET+Q D+ +S+ Sbjct: 477 --KVYELMRACWKWSPADRPS---FAETHQAFETMFHDSSISE 514 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 44.3 bits (103), Expect = 2e-04 Identities = 39/158 (24%), Positives = 68/158 (43%), Gaps = 16/158 (10%) Query: 63 GQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDF 119 G N W E RT++ ++G G V+ WK++ + ++ T E ++F Sbjct: 227 GVSPNYDKW---EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 283 Query: 120 LHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--- 174 L ++K ++ ++V LLG C E ++TE+ G NL + L Q VN Sbjct: 284 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG---NLLDYLRECNRQEVNAVVL 340 Query: 175 --WQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPK 210 ++ AM+Y+ N++H + N L K Sbjct: 341 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVK 378 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 44.3 bits (103), Expect = 2e-04 Identities = 39/158 (24%), Positives = 68/158 (43%), Gaps = 16/158 (10%) Query: 63 GQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE---MKDDF 119 G N W E RT++ ++G G V+ WK++ + ++ T E ++F Sbjct: 246 GVSPNYDKW---EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 302 Query: 120 LHGLQMLKSLQGTHVVTLLGYC--EDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNT--- 174 L ++K ++ ++V LLG C E ++TE+ G NL + L Q VN Sbjct: 303 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG---NLLDYLRECNRQEVNAVVL 359 Query: 175 --WQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPK 210 ++ AM+Y+ N++H + N L K Sbjct: 360 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVK 397 >gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo sapiens] Length = 1009 Score = 44.3 bits (103), Expect = 2e-04 Identities = 40/153 (26%), Positives = 72/153 (47%), Gaps = 14/153 (9%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHK-----VALSQLT---SLEMKDDFLHGLQMLKSL 129 R +V + +GEG V+ + HK VA+ +L+ K+ F+ ++K+L Sbjct: 422 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 481 Query: 130 QGTHVVTLLGYCEDDNT-MLTEYHPLGSLSN-LEETLNLSKYQNVNTWQHRLELAMDYVS 187 H+V L+G E++ T ++ E +P G L + LE N K + + ++ AM Y+ Sbjct: 482 DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLE 541 Query: 188 IINYLHHSPVGTRVMCDSNDLPKT----LSQYL 216 IN +H ++ S + K LS+Y+ Sbjct: 542 SINCVHRDIAVRNILVASPECVKLGDFGLSRYI 574 >gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo sapiens] Length = 967 Score = 44.3 bits (103), Expect = 2e-04 Identities = 40/153 (26%), Positives = 72/153 (47%), Gaps = 14/153 (9%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHK-----VALSQLT---SLEMKDDFLHGLQMLKSL 129 R +V + +GEG V+ + HK VA+ +L+ K+ F+ ++K+L Sbjct: 422 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 481 Query: 130 QGTHVVTLLGYCEDDNT-MLTEYHPLGSLSN-LEETLNLSKYQNVNTWQHRLELAMDYVS 187 H+V L+G E++ T ++ E +P G L + LE N K + + ++ AM Y+ Sbjct: 482 DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLE 541 Query: 188 IINYLHHSPVGTRVMCDSNDLPKT----LSQYL 216 IN +H ++ S + K LS+Y+ Sbjct: 542 SINCVHRDIAVRNILVASPECVKLGDFGLSRYI 574 >gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo sapiens] Length = 1009 Score = 44.3 bits (103), Expect = 2e-04 Identities = 40/153 (26%), Positives = 72/153 (47%), Gaps = 14/153 (9%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHK-----VALSQLT---SLEMKDDFLHGLQMLKSL 129 R +V + +GEG V+ + HK VA+ +L+ K+ F+ ++K+L Sbjct: 422 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 481 Query: 130 QGTHVVTLLGYCEDDNT-MLTEYHPLGSLSN-LEETLNLSKYQNVNTWQHRLELAMDYVS 187 H+V L+G E++ T ++ E +P G L + LE N K + + ++ AM Y+ Sbjct: 482 DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLE 541 Query: 188 IINYLHHSPVGTRVMCDSNDLPKT----LSQYL 216 IN +H ++ S + K LS+Y+ Sbjct: 542 SINCVHRDIAVRNILVASPECVKLGDFGLSRYI 574 >gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo sapiens] Length = 1009 Score = 44.3 bits (103), Expect = 2e-04 Identities = 40/153 (26%), Positives = 72/153 (47%), Gaps = 14/153 (9%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEHK-----VALSQLT---SLEMKDDFLHGLQMLKSL 129 R +V + +GEG V+ + HK VA+ +L+ K+ F+ ++K+L Sbjct: 422 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 481 Query: 130 QGTHVVTLLGYCEDDNT-MLTEYHPLGSLSN-LEETLNLSKYQNVNTWQHRLELAMDYVS 187 H+V L+G E++ T ++ E +P G L + LE N K + + ++ AM Y+ Sbjct: 482 DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLE 541 Query: 188 IINYLHHSPVGTRVMCDSNDLPKT----LSQYL 216 IN +H ++ S + K LS+Y+ Sbjct: 542 SINCVHRDIAVRNILVASPECVKLGDFGLSRYI 574 >gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] Length = 612 Score = 43.1 bits (100), Expect = 4e-04 Identities = 32/138 (23%), Positives = 62/138 (44%), Gaps = 6/138 (4%) Query: 71 WLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE-----MKDDFLHGLQM 125 +L + L E ++L G VK+ + K K ++ E +KD+ L + Sbjct: 341 YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 400 Query: 126 LKSLQGTHVVTLLGYCEDDNTMLT-EYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMD 184 ++ L ++V ++G CE ++ ML E LG L+ + K +N+ H++ + M Sbjct: 401 MQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 460 Query: 185 YVSIINYLHHSPVGTRVM 202 Y+ N++H V+ Sbjct: 461 YLEESNFVHRDLAARNVL 478 >gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] Length = 635 Score = 43.1 bits (100), Expect = 4e-04 Identities = 32/138 (23%), Positives = 62/138 (44%), Gaps = 6/138 (4%) Query: 71 WLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLE-----MKDDFLHGLQM 125 +L + L E ++L G VK+ + K K ++ E +KD+ L + Sbjct: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 Query: 126 LKSLQGTHVVTLLGYCEDDNTMLT-EYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMD 184 ++ L ++V ++G CE ++ ML E LG L+ + K +N+ H++ + M Sbjct: 424 MQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 Query: 185 YVSIINYLHHSPVGTRVM 202 Y+ N++H V+ Sbjct: 484 YLEESNFVHRDLAARNVL 501 >gi|187475373 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 41.6 bits (96), Expect = 0.001 Identities = 38/159 (23%), Positives = 76/159 (47%), Gaps = 7/159 (4%) Query: 80 EVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLG 139 E++ L+ +G+G V L +++ +KVA+ + + FL ++ L+ +++V LLG Sbjct: 194 ELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 Query: 140 YCEDDN---TMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLEL--AMDYVSIINYLHH 194 ++ ++TEY GSL + + S + L++ AM+Y+ N++H Sbjct: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 Query: 195 SPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPL 233 V+ +++ K +S + LT S D LP+ Sbjct: 314 DLAARNVLVSEDNVAK-VSDFGLTKEAS-STQDTGKLPV 350 >gi|4758078 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 41.6 bits (96), Expect = 0.001 Identities = 38/159 (23%), Positives = 76/159 (47%), Gaps = 7/159 (4%) Query: 80 EVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLG 139 E++ L+ +G+G V L +++ +KVA+ + + FL ++ L+ +++V LLG Sbjct: 194 ELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 Query: 140 YCEDDN---TMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLEL--AMDYVSIINYLHH 194 ++ ++TEY GSL + + S + L++ AM+Y+ N++H Sbjct: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 Query: 195 SPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPL 233 V+ +++ K +S + LT S D LP+ Sbjct: 314 DLAARNVLVSEDNVAK-VSDFGLTKEAS-STQDTGKLPV 350 >gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] Length = 451 Score = 41.2 bits (95), Expect = 0.001 Identities = 40/154 (25%), Positives = 67/154 (43%), Gaps = 21/154 (13%) Query: 71 WLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEH-KVALSQLTSLEMKDDFLH------GL 123 W E R E +++G G VF WK+ +VA+ ++ +D+ LH + Sbjct: 181 WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVIS----RDNLLHQQMLQSEI 236 Query: 124 QMLKSLQGTHVVTLLGYCE--DDNTMLTEYHPLGSLSNL-----EETLNLSKYQNVNTWQ 176 Q +K L+ H++ L D ++TE GSL L E+ L +S+ ++ WQ Sbjct: 237 QAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDI-AWQ 295 Query: 177 HRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPK 210 + M Y+ NY+H ++ N L K Sbjct: 296 --VAEGMCYLESQNYIHRDLAARNILVGENTLCK 327 >gi|21735566 mitogen-activated protein kinase kinase kinase 7 isoform D [Homo sapiens] Length = 491 Score = 40.8 bits (94), Expect = 0.002 Identities = 30/114 (26%), Positives = 50/114 (43%), Gaps = 3/114 (2%) Query: 80 EVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLG 139 E+ + VG GA V ++W+ VA+ Q+ S + F+ L+ L + ++V L G Sbjct: 35 EIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYG 94 Query: 140 YCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLH 193 C + ++ EY GSL N+ Y T H + + + YLH Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYY---TAAHAMSWCLQCSQGVAYLH 145 >gi|21735564 mitogen-activated protein kinase kinase kinase 7 isoform C [Homo sapiens] Length = 518 Score = 40.8 bits (94), Expect = 0.002 Identities = 30/114 (26%), Positives = 50/114 (43%), Gaps = 3/114 (2%) Query: 80 EVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLG 139 E+ + VG GA V ++W+ VA+ Q+ S + F+ L+ L + ++V L G Sbjct: 35 EIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYG 94 Query: 140 YCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLH 193 C + ++ EY GSL N+ Y T H + + + YLH Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYY---TAAHAMSWCLQCSQGVAYLH 145 >gi|21735562 mitogen-activated protein kinase kinase kinase 7 isoform B [Homo sapiens] Length = 606 Score = 40.8 bits (94), Expect = 0.002 Identities = 30/114 (26%), Positives = 50/114 (43%), Gaps = 3/114 (2%) Query: 80 EVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLG 139 E+ + VG GA V ++W+ VA+ Q+ S + F+ L+ L + ++V L G Sbjct: 35 EIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYG 94 Query: 140 YCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLH 193 C + ++ EY GSL N+ Y T H + + + YLH Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYY---TAAHAMSWCLQCSQGVAYLH 145 >gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform A [Homo sapiens] Length = 579 Score = 40.8 bits (94), Expect = 0.002 Identities = 30/114 (26%), Positives = 50/114 (43%), Gaps = 3/114 (2%) Query: 80 EVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLG 139 E+ + VG GA V ++W+ VA+ Q+ S + F+ L+ L + ++V L G Sbjct: 35 EIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYG 94 Query: 140 YCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLH 193 C + ++ EY GSL N+ Y T H + + + YLH Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYY---TAAHAMSWCLQCSQGVAYLH 145 >gi|130977759 tec protein tyrosine kinase [Homo sapiens] Length = 631 Score = 40.4 bits (93), Expect = 0.002 Identities = 55/267 (20%), Positives = 114/267 (42%), Gaps = 19/267 (7%) Query: 79 TEVRQLKRVGEGAVKRVFLSEWK-EHKVALSQLTSLEM-KDDFLHGLQMLKSLQGTHVVT 136 +E+ ++ +G G V L +W+ ++KVA+ + M ++DF+ +++ L +V Sbjct: 368 SELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 427 Query: 137 LLGYCEDDNTM--LTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHH 194 L G C + +TE+ G L N L + Q + L + D + YL Sbjct: 428 LYGVCTQQKPIYIVTEFMERGCLLNF-----LRQRQGHFSRDVLLSMCQDVCEGMEYLER 482 Query: 195 SPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCGHREL--HGD 252 + R + N L + S+F + LD + + VK E+ + Sbjct: 483 NSFIHRDLAARNCLVSEAG-VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSR 541 Query: 253 FVAPEQLWPYGEDV--PFHDDLMPSYDEKIDIWKIPDISSFLLGH-IEGSDMVRFHLFDI 309 F + +W +G + F + MP EK +++ ++ GH + + +++++ Sbjct: 542 FSSKSDVWSFGVLMWEVFTEGRMPF--EKYTNYEV--VTMVTRGHRLYQPKLASNYVYEV 597 Query: 310 HKACKSQTPSERPTAQDVLETYQKVLD 336 C + P RP+ +D+L T ++++ Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTIDELVE 624 >gi|29725609 epidermal growth factor receptor isoform a precursor [Homo sapiens] Length = 1210 Score = 39.7 bits (91), Expect = 0.004 Identities = 50/202 (24%), Positives = 83/202 (41%), Gaps = 21/202 (10%) Query: 79 TEVRQLKRVGEGAVKRVFLSEWKEH------KVALSQL---TSLEMKDDFLHGLQMLKSL 129 TE +++K +G GA V+ W VA+ +L TS + + L ++ S+ Sbjct: 710 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 769 Query: 130 QGTHVVTLLGYCEDDNT-MLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSI 188 HV LLG C ++T+ P G L + + ++++ Q+ L + Sbjct: 770 DNPHVCRLLGICLTSTVQLITQLMPFGCLLDY-----VREHKDNIGSQYLLNWCVQIAKG 824 Query: 189 INYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCG--- 245 +NYL + R + N L KT Q++ ++F LA L A H+ G V Sbjct: 825 MNYLEDRRLVHRDLAARNVLVKT-PQHVKITDFG-LAKLLGAEEKEYHAEGGKVPIKWMA 882 Query: 246 -HRELHGDFVAPEQLWPYGEDV 266 LH + +W YG V Sbjct: 883 LESILHRIYTHQSDVWSYGVTV 904 >gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] Length = 537 Score = 39.7 bits (91), Expect = 0.004 Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%) Query: 78 RTEVRQLKRVGEGAVKRVFLSEWKEH-KVALSQLTSLEMK-DDFLHGLQMLKSLQGTHVV 135 R ++ +KR+G G V++ W + KVA+ L M + FL Q++K L+ +V Sbjct: 268 RESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLV 327 Query: 136 TLLG-YCEDDNTMLTEYHPLGSLSNL--EETLNLSKYQNVNTWQHRLELAMDYVSIINYL 192 L E+ ++TEY GSL + + K N+ ++ M Y+ +NY+ Sbjct: 328 QLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 193 H 193 H Sbjct: 388 H 388 >gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] Length = 1061 Score = 39.7 bits (91), Expect = 0.004 Identities = 27/102 (26%), Positives = 50/102 (49%), Gaps = 9/102 (8%) Query: 100 WKEHKVALSQLTS--LEMKDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTM--LTEYHPLG 155 +K + VA+ ++ +E+ L L+ ++ +Q H+ +G C D + LTEY P G Sbjct: 559 YKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRG 618 Query: 156 SLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHSPV 197 SL ++ E +++ W R L D V + +LH+ + Sbjct: 619 SLQDILENESITL-----DWMFRYSLTNDIVKGMLFLHNGAI 655 >gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 38.5 bits (88), Expect = 0.009 Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 16/161 (9%) Query: 44 APRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWK-- 101 +P +++ + + F ++KN + + ++ G G V + +++ Sbjct: 28 SPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA 87 Query: 102 -EHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCE--DDNTMLTEYHPLGS-- 156 + A+ +T+ E+K F ++++ Q ++V LLG+ DD ++ Y P GS Sbjct: 88 VKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLL 147 Query: 157 --LSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHS 195 LS L+ T LS W R ++A + IN+LH + Sbjct: 148 DRLSCLDGTPPLS-------WHMRCKIAQGAANGINFLHEN 181 >gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 38.5 bits (88), Expect = 0.009 Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 16/161 (9%) Query: 44 APRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWK-- 101 +P +++ + + F ++KN + + ++ G G V + +++ Sbjct: 28 SPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA 87 Query: 102 -EHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCE--DDNTMLTEYHPLGS-- 156 + A+ +T+ E+K F ++++ Q ++V LLG+ DD ++ Y P GS Sbjct: 88 VKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLL 147 Query: 157 --LSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHS 195 LS L+ T LS W R ++A + IN+LH + Sbjct: 148 DRLSCLDGTPPLS-------WHMRCKIAQGAANGINFLHEN 181 >gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 38.5 bits (88), Expect = 0.009 Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 16/161 (9%) Query: 44 APRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWK-- 101 +P +++ + + F ++KN + + ++ G G V + +++ Sbjct: 28 SPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA 87 Query: 102 -EHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCE--DDNTMLTEYHPLGS-- 156 + A+ +T+ E+K F ++++ Q ++V LLG+ DD ++ Y P GS Sbjct: 88 VKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLL 147 Query: 157 --LSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHS 195 LS L+ T LS W R ++A + IN+LH + Sbjct: 148 DRLSCLDGTPPLS-------WHMRCKIAQGAANGINFLHEN 181 >gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 38.5 bits (88), Expect = 0.009 Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 16/161 (9%) Query: 44 APRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWK-- 101 +P +++ + + F ++KN + + ++ G G V + +++ Sbjct: 152 SPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA 211 Query: 102 -EHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCE--DDNTMLTEYHPLGS-- 156 + A+ +T+ E+K F ++++ Q ++V LLG+ DD ++ Y P GS Sbjct: 212 VKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLL 271 Query: 157 --LSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHS 195 LS L+ T LS W R ++A + IN+LH + Sbjct: 272 DRLSCLDGTPPLS-------WHMRCKIAQGAANGINFLHEN 305 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,656,680 Number of Sequences: 37866 Number of extensions: 594834 Number of successful extensions: 1605 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 12 Number of HSP's successfully gapped in prelim test: 96 Number of HSP's that attempted gapping in prelim test: 1540 Number of HSP's gapped (non-prelim): 130 length of query: 350 length of database: 18,247,518 effective HSP length: 103 effective length of query: 247 effective length of database: 14,347,320 effective search space: 3543788040 effective search space used: 3543788040 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.