Guide to the Human Genome
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Search of human proteins with 87298937

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|87298937 centrosomal protein 110kDa [Homo sapiens]
         (2325 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|87298937 centrosomal protein 110kDa [Homo sapiens]                4489   0.0  
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    198   6e-50
gi|21735548 centrosomal protein 2 [Homo sapiens]                      182   3e-45
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   180   1e-44
gi|71061468 centromere protein E [Homo sapiens]                       180   2e-44
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   177   1e-43
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   177   1e-43
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   177   1e-43
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   177   1e-43
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   174   9e-43
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   173   2e-42
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            173   2e-42
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   170   2e-41
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      169   3e-41
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   168   6e-41
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   167   8e-41
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   164   9e-40
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   164   1e-39
gi|4506751 restin isoform a [Homo sapiens]                            162   5e-39
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   161   6e-39
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   159   2e-38
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   159   3e-38
gi|50083279 centrosome protein 4 [Homo sapiens]                       159   4e-38
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   157   9e-38
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   157   9e-38
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  157   1e-37
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          157   1e-37
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          157   1e-37
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          157   1e-37
gi|55770834 centromere protein F [Homo sapiens]                       157   1e-37

>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 4489 bits (11643), Expect = 0.0
 Identities = 2325/2325 (100%), Positives = 2325/2325 (100%)

Query: 1    MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD 60
            MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD
Sbjct: 1    MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD 60

Query: 61   ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN 120
            ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN
Sbjct: 61   ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN 120

Query: 121  LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE 180
            LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE
Sbjct: 121  LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE 180

Query: 181  IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT 240
            IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT
Sbjct: 181  IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT 240

Query: 241  IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI 300
            IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI
Sbjct: 241  IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI 300

Query: 301  KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
            KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK
Sbjct: 301  KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360

Query: 361  IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE 420
            IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE
Sbjct: 361  IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE 420

Query: 421  QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA 480
            QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA
Sbjct: 421  QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA 480

Query: 481  IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI 540
            IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI
Sbjct: 481  IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI 540

Query: 541  DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT 600
            DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT
Sbjct: 541  DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT 600

Query: 601  EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
            EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER
Sbjct: 601  EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660

Query: 661  DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720
            DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN
Sbjct: 661  DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720

Query: 721  QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780
            QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD
Sbjct: 721  QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780

Query: 781  DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL 840
            DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL
Sbjct: 781  DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL 840

Query: 841  ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
            ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF
Sbjct: 841  ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900

Query: 901  DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL 960
            DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL
Sbjct: 901  DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL 960

Query: 961  EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
            EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ
Sbjct: 961  EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020

Query: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL 1080
            EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL
Sbjct: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL 1080

Query: 1081 NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140
            NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR
Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140

Query: 1141 GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW 1200
            GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW
Sbjct: 1141 GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW 1200

Query: 1201 VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM 1260
            VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM
Sbjct: 1201 VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM 1260

Query: 1261 ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN 1320
            ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN
Sbjct: 1261 ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN 1320

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
            LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380

Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
            HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440

Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
            LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500

Query: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 1560
            LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN
Sbjct: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 1560

Query: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620
            EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA
Sbjct: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620

Query: 1621 KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
            KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE
Sbjct: 1621 KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680

Query: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
            EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740

Query: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
            ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800

Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
            KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860

Query: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK 1920
            EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK
Sbjct: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK 1920

Query: 1921 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1980
            EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK
Sbjct: 1921 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1980

Query: 1981 ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE 2040
            ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE
Sbjct: 1981 ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE 2040

Query: 2041 LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC 2100
            LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC
Sbjct: 2041 LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC 2100

Query: 2101 IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL 2160
            IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL
Sbjct: 2101 IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL 2160

Query: 2161 KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL 2220
            KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL
Sbjct: 2161 KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL 2220

Query: 2221 NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
            NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ
Sbjct: 2221 NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280

Query: 2281 VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
            VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR
Sbjct: 2281 VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  198 bits (503), Expect = 6e-50
 Identities = 248/1086 (22%), Positives = 474/1086 (43%), Gaps = 138/1086 (12%)

Query: 1322 ENEVSRLEDIMQHLKSKK--------------REERWMRASKRQSEKEMEELHHNIDDLL 1367
            EN ++ +E +   L ++K               E   +RA     ++E+EE+ H+++  +
Sbjct: 865  ENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924

Query: 1368 QEKKS----LECEVEELHRTVQKRQQQKDFIDG-----NVESLMTELEIEKSLKHHEDIV 1418
            +E++     L+ E +++ + +Q+ ++Q +  +       +E + TE +++K L+  + I+
Sbjct: 925  EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK-LEEEQIIL 983

Query: 1419 DEIEC---IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE-KFTDAKRSLLQTE 1474
            ++  C    EK LL+ R  + E    L E E E S +  K KN  E   TD +  L + E
Sbjct: 984  EDQNCKLAKEKKLLEDR--IAEFTTNLTE-EEEKSKSLAKLKNKHEAMITDLEERLRREE 1040

Query: 1475 SDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQ 1534
               +ELE+  ++   +      Q+  LQA   +L+    K+EE L+     V  + +   
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100

Query: 1535 CLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQ 1594
               KK  +L  ++ +LQ+D+E    + +   +  ++    L+A + ELE       +QQ+
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160

Query: 1595 EMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE--- 1651
              +  ++++   K+ L     +      ++++       E+ E+    + VK+ LE+   
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220

Query: 1652 -LSFQKGELNVQIS---ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQL 1707
             L  ++GEL  ++    + K      ++++E + + LQV   +  + +TEL + +  LQ+
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280

Query: 1708 ENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKRE 1767
            E   + GL  Q D + S+L K   A+  +  + + L Q   +QK  +  + + +E +K  
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340

Query: 1768 I-ERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEK 1826
              E++  E  A  +    L K+   L  +    +KK+  +   L  AEE  +  Q +LE 
Sbjct: 1341 FREQLEEEEEAKHN----LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396

Query: 1827 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
            L     +     D+L + K  L  ++  +   L  +R++  +L+++              
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK-------------- 1442

Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
                 K  D LL+E+  +    +E  +R E   +E+ETK   L     E  E K +L   
Sbjct: 1443 ----QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL--- 1495

Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
                +RL K+  +E   L +SK  + +  H+LEK     + +++++ +++   E+ ++  
Sbjct: 1496 ----ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551

Query: 2007 QEEERWCE-SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTE 2065
            ++ +   E +L+   +Q +R L  R++Q  EK  +L+   +E ++   D    R+  +  
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611

Query: 2066 RKKAE---------------------KQVASLKEALKIQRSQLE------KNLLEQKQEN 2098
            RKK E                     KQ+  L+  +K    +L+      + +L Q +EN
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671

Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL------ERRQME 2152
                K M    +  Q+    A R  +   Q Q E  EL  ++AN          E+R++E
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKR---QAQQERDELADEIANSSGKGALALEEKRRLE 1728

Query: 2153 ISDAMRTLKSEVKDE------IRTSLKNLNQFLPELPADL---EAILERNENLEGELESL 2203
               A   L+ E+++E      I   LK  N  + ++  DL    +  ++NEN   +LE  
Sbjct: 1729 ARIAQ--LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1786

Query: 2204 KENLPFTMN--EGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAE 2261
             + L   +   EG  + K   S            AL  K+   E++L  +     +K+ +
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASIT----------ALEAKIAQLEEQLDNE-----TKERQ 1831

Query: 2262 VLIKGKRQTEGTLHSLRRQVD--ALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQE 2319
               K  R+TE  L  +  QVD            AD AS+  L QL+  L E  +  + Q 
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST-RLKQLKRQLEEAEE--EAQR 1888

Query: 2320 KNASAR 2325
             NAS R
Sbjct: 1889 ANASRR 1894



 Score =  139 bits (350), Expect = 3e-32
 Identities = 211/963 (21%), Positives = 423/963 (43%), Gaps = 133/963 (13%)

Query: 251  EGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSL 310
            E + V  +++Q A E   L E+E L+  L  + ++ +E    +T    E    ++L   L
Sbjct: 851  EEELVKVREKQLAAEN-RLTEMETLQSQLMAEKLQLQEQLQAETELCAEA---EELRARL 906

Query: 311  KEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNY 370
              +    ++ C +L++ +  + E  +    E  +  Q   ELE++L   +   +   L  
Sbjct: 907  TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966

Query: 371  YPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLR 430
              +E A++ K  +E   +     K    A E  +++   A     +  +E+       L+
Sbjct: 967  VTTE-AKLKKLEEEQIILEDQNCK---LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022

Query: 431  G-HTPLDTQLEDKEKKISAAQTRL-----------SELHDEIEKAEQQILRATEEFKQLE 478
              H  + T LE++ ++    +  L           ++L D+I + + QI     +  + E
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082

Query: 479  EAIQ--LKKISE--AGKDLLYKQLSGRLQLVNKLRQEALDLEL----QMEKQKQEIAGKQ 530
            E +Q  L ++ E  A K++  K++      +++L QE L+ E     + EKQK+++  + 
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRNKAEKQKRDLGEEL 1141

Query: 531  KEIK-DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY-QQLESRLDEILSRIAKE 588
            + +K +L+   D+LDS     +  +  +S +EQ+++I+ K   ++ ++   +I     K 
Sbjct: 1142 EALKTELE---DTLDST----AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194

Query: 589  TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
            ++ +++L EQL            +  + V + L++   T++ +  +  NE + L   K  
Sbjct: 1195 SQAVEELAEQL------------EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242

Query: 649  LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQ-EQHEVNASLQQTQG-------D 700
               +  +VE +  +L++   + E +R ELA+  + LQ E   V   L Q+         D
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302

Query: 701  LSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQF 760
             SA E++L+    L   E N+ K  L    +  + E+++ + +LE+E +A  N       
Sbjct: 1303 FSALESQLQDTQELLQ-EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL------ 1355

Query: 761  SEEKEQENSELHAK---LKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEVAARVDEL 816
                E++ + LHA+   +K   +D+    +  ++ +  L   ++GL  R EE  A  D+L
Sbjct: 1356 ----EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411

Query: 817  RR-KLKLGTGEMNIHSPSDVLGKSLADL---QKQFSEILARSKW---------ERDEAQV 863
             + K +L     ++    D   +S  +L   QK+F ++LA  K          +R EA+ 
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471

Query: 864  RERKLQ--------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQH---------E 906
            RE++ +        EE   Q+ +L    ++FR   E  + ++ +  K  H         E
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531

Query: 907  ARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERIL-AQLRELEKKKKLEDAKS 965
             ++++M+ ++  L++ L++ E+ +   ++ LQ    + ER L  +  + E+KKK    + 
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591

Query: 966  QEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERF 1025
            +E    L+ E K+   AVA   KL        +  LK L   +   N+ R E +++  + 
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKL--------EMDLKDLEAHIDSANKNRDEAIKQLRKL 1643

Query: 1026 SRKAAQAARDL--TRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
              +     R+L  TRA  E E+L      + +   +E E   +      ++   E+    
Sbjct: 1644 QAQMKDCMRELDDTRASRE-EILAQAKENEKKLKSMEAEMIQL----QEELAAAERAKRQ 1698

Query: 1084 MERQRTEIARLQNVLDLTGSDNKGGFENVLEE-------IAELRREVSYQNDYISSMADP 1136
             +++R E+A      ++  S  KG     LEE       IA+L  E+  +      + D 
Sbjct: 1699 AQQERDELAD-----EIANSSGKGAL--ALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751

Query: 1137 FKR 1139
             K+
Sbjct: 1752 LKK 1754



 Score =  132 bits (333), Expect = 3e-30
 Identities = 209/915 (22%), Positives = 385/915 (42%), Gaps = 156/915 (17%)

Query: 244  LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ 303
            L+ +  LE Q    Q+  E+ ER S  + E+ +RDL +   E E LK++    L+    Q
Sbjct: 1103 LKKIRELESQISELQEDLES-ERASRNKAEKQKRDLGE---ELEALKTELEDTLDSTAAQ 1158

Query: 304  DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
             +L    ++E  + K++ EE       + + ++QK  +      +Q E  + +      A
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            K + L     E A   K   +    G S +KR     +       Q +Q+K  E  E++R
Sbjct: 1219 K-QTLENERGELANEVKVLLQGK--GDSEHKRKKVEAQ------LQELQVKFNE-GERVR 1268

Query: 424  ND--------HMNLRGHTPLDTQLEDKEKKI----SAAQTRLSELHDEIEKAEQQILRAT 471
             +         + L   T L +Q + K  K+    SA +++L +  + +++  +Q L  +
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLS 1328

Query: 472  EEFKQLEEAI-----QLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQME------ 520
             + KQ+E+       QL++  EA K  L KQ++        L  +  D++ +ME      
Sbjct: 1329 TKLKQVEDEKNSFREQLEEEEEA-KHNLEKQIA-------TLHAQVADMKKKMEDSVGCL 1380

Query: 521  KQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLD--IMNKQYQQL---- 574
            +  +E+  K+K  KDL+      + K   +  ++  K+  +Q+LD  +++  +Q+     
Sbjct: 1381 ETAEEV--KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438

Query: 575  ----ESRLDEILSRIAKETEEIKDLEEQ-LTEGQIAANEALKKDLEGVISGLQEYLGTIK 629
                + + D++L+   ++T   K  EE+   E +    E     L   +    E    ++
Sbjct: 1439 LEKKQKKFDQLLAE--EKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496

Query: 630  GQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE 689
                Q + E   L   K+ + + + E+E+ +  LE      E M+ +L ELE  LQ   +
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE---QQVEEMKTQLEELEDELQATED 1553

Query: 690  VNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
                L+    +L A +A+ E  L  RD ++ + K++L +  R        ++AELE ER+
Sbjct: 1554 AKLRLEV---NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR-------EMEAELEDERK 1603

Query: 750  ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL-----LKQQLKDFQNHLNHVVDGLV 804
                A+  A+   E + ++ E H    +   D  +     L+ Q+KD    L+   D   
Sbjct: 1604 QRSMAVA-ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELD---DTRA 1659

Query: 805  RPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
              EE+ A+  E  +KLK    EM                  Q  E LA ++  + +AQ  
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMI-----------------QLQEELAAAERAKRQAQQE 1702

Query: 865  ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLK 924
              +L +E+A    K A   EE                KR+ EARI Q+E E+   Q N +
Sbjct: 1703 RDELADEIANSSGKGALALEE----------------KRRLEARIAQLEEELEEEQGNTE 1746

Query: 925  ---------SMEEIQGLTDLQLQEADEEKERILAQLRELEKKK---KLED------AKSQ 966
                     +++  Q  TDL L+ +  +K     Q  E + K+   KL++      +K +
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806

Query: 967  EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ---EAE 1023
              +  L+ ++ +L++ +    K   A     +   K L   +++++ ER    Q   +A+
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866

Query: 1024 RFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
            + S +  Q  R L  AE E         Q+    R ++++            E+E   ET
Sbjct: 1867 KASTRLKQLKRQLEEAEEE--------AQRANASRRKLQR------------ELEDATET 1906

Query: 1084 MERQRTEIARLQNVL 1098
             +    E++ L+N L
Sbjct: 1907 ADAMNREVSSLKNKL 1921



 Score =  127 bits (319), Expect = 1e-28
 Identities = 171/789 (21%), Positives = 338/789 (42%), Gaps = 94/789 (11%)

Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEK-------KSLECEVEEL 1380
            +E++ + L+  KR +  +  +K+  E E  EL + +  LLQ K       K +E +++EL
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257

Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
                 + ++ +  +   V  L  EL+    L    D   +   + K      S+L++   
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD--SKSSKLTKDFSALESQLQDTQE 1315

Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
            LL E   +      K K   ++    +  L + E     LE++       +    +++  
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375

Query: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA--- 1557
                 +  E+ K K ++ L+ +++    K + +  L K K +L +EL  L  D++     
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435

Query: 1558 ----ERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
                E+ +    Q+L E E  + AK AE E+ +++  ++++E   L   L    EE    
Sbjct: 1436 ACNLEKKQKKFDQLLAE-EKTISAKYAE-ERDRAEAEAREKETKALS--LARALEEA--- 1488

Query: 1614 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLI 1673
                ++ KA+L+   +   TE+ +  +   +V   + EL   K  L  Q+ E KTQL  +
Sbjct: 1489 ----MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544

Query: 1674 KQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAV 1733
            + E++  E+         +K + E+ N+  M      +LQG   Q +++  +L + QV  
Sbjct: 1545 EDELQATED---------AKLRLEV-NLQAMKAQFERDLQGRDEQSEEKKKQLVR-QVRE 1593

Query: 1734 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-RMTAESRALQSCVECLSKEKEDL 1792
            +E +LE E      ++Q+      ++ LE D +++E  + + ++     ++ L K +  +
Sbjct: 1594 MEAELEDE------RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647

Query: 1793 QEKCDIWEKKLAQTKRVLAAAEENSK----ME------QSNLEKLELNVRKLQQELDQLN 1842
            ++     +   A  + +LA A+EN K    ME      Q  L   E   R+ QQE D+L 
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL- 1706

Query: 1843 RDKLSLHNDISAMQQQLQEKREA-VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
             D+++  +   A+  + + + EA +  L+EEL   Q +  L    L       D +    
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI---N 1763

Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN------------KLKLVQQEMM 1949
            T L  + S  A + E+ +++ E + ++L+V   E+E              + K+ Q E  
Sbjct: 1764 TDLNLERSH-AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822

Query: 1950 FQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE 2009
                 KER++   ++  ++  LK+   Q++ E  + +   DQ        ++  R L+E 
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882

Query: 2010 ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ-------F 2062
            E   +    +  + +R+L +  +               AD+M  + S L+N+       F
Sbjct: 1883 EEEAQRANASRRKLQRELEDATE--------------TADAMNREVSSLKNKLRRGDLPF 1928

Query: 2063 LTERKKAEK 2071
            +  R+ A K
Sbjct: 1929 VVPRRMARK 1937



 Score =  108 bits (270), Expect = 6e-23
 Identities = 125/662 (18%), Positives = 302/662 (45%), Gaps = 49/662 (7%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            S+L+D  + L+ + R++  +    +Q E E       +++  + K +LE ++  LH  V 
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLK--------HHEDIVDEIECIEKTLLKRRSELRE 1437
              +++   ++ +V  L T  E+++ L+         HE+ V   + +EKT  + + EL  
Sbjct: 1368 DMKKK---MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL-- 1422

Query: 1438 ADRLLAEAESEL--SCTKEKTKNAVEKFTDAKRSL---LQTESDAEELERRAQET-AVNL 1491
             D LL + + +   +C  EK +   ++    ++++      E D  E E R +ET A++L
Sbjct: 1423 -DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481

Query: 1492 VKADQQLRSLQADAKDL-EQHKIKQEEILK---EINKIVAAKDSDFQCLSKKKEKLTEEL 1547
             +A ++    +A+ + L +Q + + E+++    ++ K V   +   + L ++ E++  +L
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541

Query: 1548 QKLQKDIEMAERNE---DHHLQVLK-ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQL 1603
            ++L+ +++  E  +   + +LQ +K + E  LQ +  + E+ K Q+  Q +EM   + +L
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM---EAEL 1598

Query: 1604 GHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQI 1663
              ++++  +   +  + + DL++     ++    +   I++++ L  ++     EL+   
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658

Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRV 1723
            + R+  L   K+  EK+ ++++  + Q+ +     +      Q E  EL       D+  
Sbjct: 1659 ASREEILAQAKEN-EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA------DEIA 1711

Query: 1724 SELEKTQVAVLEEKLELE----NLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
            +   K  +A LEEK  LE     L++  ++++G  E     L++   +I+++  +    +
Sbjct: 1712 NSSGKGALA-LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1770

Query: 1780 SCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD 1839
            S  +     ++ L+ +    + KL + +  +      SK + S +  LE  + +L+++LD
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTV-----KSKYKAS-ITALEAKIAQLEEQLD 1824

Query: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
               +++ +    +   +++L++    V+  +      +D  + A   L    +  +    
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884

Query: 1900 EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERES 1959
            E  R      +     ED  +  +   +++  L+N++    L  V    M ++   +   
Sbjct: 1885 EAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSD 1944

Query: 1960 EE 1961
            EE
Sbjct: 1945 EE 1946



 Score =  107 bits (268), Expect = 1e-22
 Identities = 120/536 (22%), Positives = 246/536 (45%), Gaps = 54/536 (10%)

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNR--DKLSLHNDISAMQ 1856
            W +   + K +L      S+ E+  + K E  V+  +++L   NR  +  +L + + A +
Sbjct: 827  WWRLFTKVKPLLQV----SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEK 882

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
             QLQE+ +A   L  E   ++  L   KQ+L      +++    + R++++      R +
Sbjct: 883  LQLQEQLQAETELCAEAEELRARLTAKKQEL------EEICHDLEARVEEE----EERCQ 932

Query: 1917 DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKER---ESEESKLETSKVTLKE 1973
              Q E++  QQ +Q L+ ++EE       +E   Q+LQ E+   E++  KLE  ++ L++
Sbjct: 933  HLQAEKKKMQQNIQELEEQLEE-------EESARQKLQLEKVTTEAKLKKLEEEQIILED 985

Query: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL----QEEERWCESLEKTLSQTKRQLSE 2029
            Q  +L KE    + ++ +  + +   EE+ ++L     + E     LE+ L + ++Q  E
Sbjct: 986  QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045

Query: 2030 REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEK 2089
             E+   +  G+   L  +   ++A  + L+ Q   + ++ +  +A ++E    Q++   K
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE-AAQKNMALK 1104

Query: 2090 NLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL-ER 2148
             + E + + S +Q+++ +         ++ R L +EL  ++ E  +     A Q++L  +
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164

Query: 2149 RQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLP 2208
            R+ E++   +TL+ E K      ++ + Q   +   +L   LE+ + ++  LE  K+ L 
Sbjct: 1165 REQEVNILKKTLEEEAKTH-EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223

Query: 2209 FTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKR 2268
                E   E K+            +G++      H+  +++AQL+    K  E    G+R
Sbjct: 1224 NERGELANEVKVLL--------QGKGDS-----EHKRKKVEAQLQELQVKFNE----GER 1266

Query: 2269 -QTEGTLHSLRRQVD---ALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEK 2320
             +TE      + QV+     G L  S S  S  +   S LES L +  +L Q + +
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322



 Score =  100 bits (250), Expect = 1e-20
 Identities = 171/774 (22%), Positives = 305/774 (39%), Gaps = 162/774 (20%)

Query: 466  QILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSG--RLQLVNKLRQEALDLELQMEKQK 523
            Q+ R  EE    EE  +L K+ E       KQL+   RL  +  L+ + +  +LQ+++Q 
Sbjct: 839  QVSRQEEEMMAKEE--ELVKVRE-------KQLAAENRLTEMETLQSQLMAEKLQLQEQL 889

Query: 524  QEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILS 583
            Q       E ++L+             + + A+K   E+    +  + ++ E R   + +
Sbjct: 890  QAETELCAEAEELR-------------ARLTAKKQELEEICHDLEARVEEEEERCQHLQA 936

Query: 584  RIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIKGQATQAQNECRK 641
               K  + I++LEEQL E + A  +    K   E  +  L+E    ++ Q  +   E + 
Sbjct: 937  EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 996

Query: 642  LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQT---- 697
            L D        LTE E++   L  +    E M   + +LE  L+ + +    L++T    
Sbjct: 997  LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQRQELEKTRRKL 1053

Query: 698  QGD---------------------LSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLE 736
            +GD                     L+  E EL+A L   + EA Q    L+K+  L + +
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL-ESQ 1112

Query: 737  QSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD--DNNLLKQQLKDFQN 794
             S LQ +LE ER +   A       ++K     EL A    L+D  D+   +Q+L+  + 
Sbjct: 1113 ISELQEDLESERASRNKA------EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166

Query: 795  HLNHVVDGLVRPEEVA--ARVDELRRKLKLGTGEM------------NIHSPSDVLGKSL 840
               +++   +  E     A++ E+R+K      E+            N+      L    
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226

Query: 841  ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
             +L  +   +L      + +++ + +K++ ++   Q K   G+    +  ++  + ++  
Sbjct: 1227 GELANEVKVLLQ----GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282

Query: 901  DK----------------RQHEARIQQMENEIHYLQE----------NLKSMEEIQGLTD 934
            D                 +   A   Q+++    LQE           LK +E+ +    
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342

Query: 935  LQLQEADEEKERILAQLREL-----EKKKKLEDA-----KSQEQVFGLDKELKKL----K 980
             QL+E +E K  +  Q+  L     + KKK+ED+      ++E    L K+L+ L    +
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402

Query: 981  KAVATSDKL-------------ATAELTIAKDQLKSLHGTVMKINQERAEE----LQEAE 1023
            + VA  DKL                +L   +    +L     K +Q  AEE     + AE
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462

Query: 1024 RFSRKAAQAARDLTRAEAEIELLQNLLRQKGE------QFRLEME-----KTGVGTGANS 1072
               R  A+A    T+A +    L+  + QK E      QFR EME     K  VG   + 
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522

Query: 1073 QVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
                   L + +E  +T++  L++ L  T             E A+LR EV+ Q
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQAT-------------EDAKLRLEVNLQ 1563



 Score =  100 bits (250), Expect = 1e-20
 Identities = 170/727 (23%), Positives = 315/727 (43%), Gaps = 132/727 (18%)

Query: 155  SYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRV--------LNLKGNKIS 206
            S +K  K+E       LQ+L +  NE E +   L  K+  L+V        L+   +K S
Sbjct: 1243 SEHKRKKVEA-----QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297

Query: 207  SL-QDISKLKP-LQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAF 264
             L +D S L+  LQD   L+  EN                R   SL  +    +D + +F
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEEN----------------RQKLSLSTKLKQVEDEKNSF 1341

Query: 265  ERFSLEEVERLERDLEKKMI----ETEELKSKQTRFL------EEIKNQDKLNKSLK--- 311
             R  LEE E  + +LEK++     +  ++K K    +      EE+K   KL K L+   
Sbjct: 1342 -REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR--KLQKDLEGLS 1398

Query: 312  ---EEAMLQKQSCEELKSDLNTK-NELLKQKTIELTRAC---QKQYELEQELAFYK-IDA 363
               EE +      E+ K+ L  + ++LL     +   AC   +KQ + +Q LA  K I A
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            K+           E D+A  E+      R K     + +  ++ A   + +    ++Q R
Sbjct: 1459 KYAE---------ERDRAEAEA------REKETKALSLARALEEAMEQKAELERLNKQFR 1503

Query: 424  NDHMNLRGHTP-LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ 482
             +  +L      +   + + EK   A + ++ E+  ++E+ E + L+ATE+ K     ++
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE-LQATEDAK-----LR 1557

Query: 483  LKKISEAGKDLLYKQLSGR--------LQLVNKLRQEALDLELQMEKQKQEIAGKQK--- 531
            L+   +A K    + L GR         QLV ++R+   +LE + +++   +A ++K   
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617

Query: 532  EIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
            ++KDL+  IDS +    +   +K  +  + Q  D M +      SR +EIL++  +  ++
Sbjct: 1618 DLKDLEAHIDSANKN--RDEAIKQLRKLQAQMKDCMRELDDTRASR-EEILAQAKENEKK 1674

Query: 592  IKDLEEQLTEGQ--IAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649
            +K +E ++ + Q  +AA E  K+  +     L + +    G+   A  E R+L      L
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQL 1734

Query: 650  LQRLTEVEQERD-----------QLEIVAMDAENMRKELAELESALQ----EQHEVNASL 694
             + L E +   +           Q++ +  D    R    + E+A Q    +  E+   L
Sbjct: 1735 EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794

Query: 695  QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA 754
            Q+ +G +   +++ +A +   +A+  QL+E+L+  T+    E+ A   ++ +  + LK+ 
Sbjct: 1795 QEMEGTV---KSKYKASITALEAKIAQLEEQLDNETK----ERQAACKQVRRTEKKLKDV 1847

Query: 755  LGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVD 814
            L       + E+ N+E +      +D  +    +LK  +  L          EE A R +
Sbjct: 1848 L----LQVDDERRNAEQY------KDQADKASTRLKQLKRQLEEA-------EEEAQRAN 1890

Query: 815  ELRRKLK 821
              RRKL+
Sbjct: 1891 ASRRKLQ 1897



 Score = 88.2 bits (217), Expect = 9e-17
 Identities = 113/506 (22%), Positives = 225/506 (44%), Gaps = 70/506 (13%)

Query: 1320 NLENEVSRLEDIMQHLKS---KKREER-WMRASKRQSEKEMEELHHNIDDLLQEKKSLE- 1374
            NLE +  + + ++   K+   K  EER    A  R+ E +   L   +++ +++K  LE 
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497

Query: 1375 ------CEVEELH-------RTVQKRQQQKDFIDGNVESLMTELE-IEKSLKHHEDIVDE 1420
                   E+E+L        ++V + ++ K  ++  VE + T+LE +E  L+  ED    
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557

Query: 1421 IEC--------IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQ 1472
            +E          E+ L  R  +  E  + L     E+    E  +        A++ L  
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-- 1615

Query: 1473 TESDAEELERRAQETAVNLVKADQQLRSLQADAKD----LEQHKIKQEEILKEINKIVAA 1528
             E D ++LE        N  +A +QLR LQA  KD    L+  +  +EEIL +      A
Sbjct: 1616 -EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ------A 1668

Query: 1529 KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQ 1588
            K+++     KK + +  E+ +LQ+++  AER +    Q  +E + L      E+     +
Sbjct: 1669 KENE-----KKLKSMEAEMIQLQEELAAAERAKR---QAQQERDELAD----EIANSSGK 1716

Query: 1589 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEA-LRLGE--TEVTEKCNHIREV 1645
                 +E   L+ ++   +EEL   QG+       L++A L++ +  T++  + +H ++ 
Sbjct: 1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN 1776

Query: 1646 KSLLEELSFQKGELNVQISER--------KTQLTLIKQEIEKEEENL-------QVVLRQ 1690
            ++  ++L  Q  EL V++ E         K  +T ++ +I + EE L       Q   +Q
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836

Query: 1691 MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQ 1750
            + + + +LK++L  +  E    +  K Q D+  + L++ +  + E + E +      ++ 
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

Query: 1751 KGEIEWQKQLLERDKREIERMTAESR 1776
            + E+E   +  +   RE+  +  + R
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLR 1922



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 52/226 (23%), Positives = 107/226 (47%), Gaps = 28/226 (12%)

Query: 888  QACERALEARMNFDKRQHEARIQQM--ENEIHYLQ----ENLKSMEEIQGLTDLQLQEAD 941
            QAC R   AR  F KRQ +    ++   N   YL+    +  +   +++ L  +  QE +
Sbjct: 787  QACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEE 846

Query: 942  ---EEKERILAQLRELEKKKKLEDAKS-QEQVFG----LDKELKKLKKAVATSDKLATAE 993
               +E+E +  + ++L  + +L + ++ Q Q+      L ++L+   +  A +++L  A 
Sbjct: 847  MMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL-RAR 905

Query: 994  LTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
            LT  K +L+ +   +    +E  E  Q  +   +K  Q  +         EL + L  ++
Sbjct: 906  LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ---------ELEEQLEEEE 956

Query: 1054 GEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
              + +L++EK  V T A  + LE E++   +E Q  ++A+ + +L+
Sbjct: 957  SARQKLQLEK--VTTEAKLKKLEEEQI--ILEDQNCKLAKEKKLLE 998



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 53/281 (18%), Positives = 115/281 (40%), Gaps = 34/281 (12%)

Query: 245  RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQD 304
            + L+S+E + +  Q+   A ER       + +++ ++   E      K    LEE +  +
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAK----RQAQQERDELADEIANSSGKGALALEEKRRLE 1728

Query: 305  KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
                 L+EE   ++ + E +   L   N  + Q   +L    ++ +  + E A  +++ +
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN--LERSHAQKNENARQQLERQ 1786

Query: 365  FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
             +          E+     E     KS+YK ++ A E+ I            + +EQL N
Sbjct: 1787 NK----------ELKVKLQEMEGTVKSKYKASITALEAKIA-----------QLEEQLDN 1825

Query: 425  DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL----EEA 480
            +    +       Q+   EKK+     ++ +     E+ + Q  +A+   KQL    EEA
Sbjct: 1826 ETKERQAACK---QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882

Query: 481  IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEK 521
             +  + + A +  L ++L    +  + + +E   L+ ++ +
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  182 bits (463), Expect = 3e-45
 Identities = 215/981 (21%), Positives = 425/981 (43%), Gaps = 102/981 (10%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            + L+D+ + L   + E+      +   E E+ ELH  +  L    +  E +  E     +
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
              Q  K+ +   VE L   +   ++      I++E     ++ LK ++E  E++R  A+A
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404

Query: 1446 ESELSCTKEKTKNAV-EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQAD 1504
              E    K     A+ E      ++L + E + E L  + QE           L  L  D
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 1505 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLT---EELQKLQKDIEMAERNE 1561
             K   Q    Q+E ++E+ K  +  +     + ++++KLT   E++++L+KD E      
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524

Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK 1621
            +H L  L++ + +++++R +++ LK Q+ +   E   L+ +  H K E    Q  +++  
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTL--ECLALELEENHHKMEC---QQKLIKEL 1579

Query: 1622 ADLQEALRLGETEVT----EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
               +E  R+  T +T    E+   ++   S + +L      L  ++ ER        QE+
Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD-------QEV 1632

Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS----ELEKTQVAV 1733
            + + E ++ + RQ      +L+     L L+   +Q L+ Q  ++      +LE+ ++++
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692

Query: 1734 LEEKLELENLQQISQQQ----KGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEK 1789
             E   EL   +Q+ Q++    KG  + Q+  LE  K  +     E    Q  +  L + K
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752

Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKL----ELNVRKLQQELDQLNRDK 1845
            + L+++     +K+ +T  +L+  E+   + Q  L++     EL  + LQ +LD+  R  
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL 1812

Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
                 ++ A+QQ+ Q+ +     ++E+   +Q  L  A     H T      L E+    
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA-----HMT------LKERHGEL 1861

Query: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE 1965
            +D  E A R E+   E   + +++Q L+  + + + +  +QE     LQ++   +  + E
Sbjct: 1862 QDHKEQARRLEE---ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918

Query: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE--ERWCESLEKTLSQT 2023
                 L++   Q +  L ++  +L+      L AE +    QEE      E+L++ L + 
Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELE-----ALRAESQSSRHQEEAARARAEALQEALGKA 1973

Query: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
               L  +EQ L+E++    +L+    +++A                +     L+EAL+IQ
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEASTATLQASLDA-----------CQAHSRQLEEALRIQ 2022

Query: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ 2143
              +++   L  +++   +Q+ +A  +   +   ER + L K L Q   E    +KQ   Q
Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ 2082

Query: 2144 KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESL 2203
               ER + EI    R L   V+ E++ +L    Q + EL        ++  NLE      
Sbjct: 2083 ---EREEEEI----RGLHQSVR-ELQLTLAQKEQEILELRE-----TQQRNNLEA----- 2124

Query: 2204 KENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQ---- 2259
               LP +    P EE           +  + ++L  +L+   +RL+A LR   +++    
Sbjct: 2125 ---LPHSHKTSPMEE-----------QSLKLDSLEPRLQRELERLQAALRQTEAREIEWR 2170

Query: 2260 --AEVLIKGKRQTEGTLHSLR 2278
              A+ L     QT+ ++ SL+
Sbjct: 2171 EKAQDLALSLAQTKASVSSLQ 2191



 Score =  169 bits (427), Expect = 4e-41
 Identities = 235/1114 (21%), Positives = 490/1114 (43%), Gaps = 139/1114 (12%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRAS-----KRQSEKEMEELHHNIDDLLQEKK 1371
            E   LE  +   +  M+ +++++ EER    S     + ++EKE   L   ++ LLQ +K
Sbjct: 883  EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL---LETLLQTQK 939

Query: 1372 SLECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEK 1426
             L    ++L R  Q  + QK         L T+L     E++++ + H D +  ++    
Sbjct: 940  ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999

Query: 1427 TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
            +LL+ + +L++    + + +S+L    +  +   ++  +  R   +     +ELER    
Sbjct: 1000 SLLQDKMDLQKQ---VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS 1056

Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEE 1546
              ++L++ +Q+L  LQ      E   I+Q+E L  + + +     + + LS + E L +E
Sbjct: 1057 LTLSLMEKEQRLLVLQ------EADSIRQQE-LSALRQDMQEAQGEQKELSAQMELLRQE 1109

Query: 1547 LQKLQKDI-----EMAERNEDHHL--QVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL 1599
            +++ + D      ++ E  E  H+  Q L+ S    +AK A+L+ L+ + T  Q E    
Sbjct: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAA 1168

Query: 1600 DRQLGHKKEELHLLQGSMVQAKADLQEALRL---GETEVTEKCNHIREVKSLLEELS--- 1653
            ++Q G++ +     Q  +    + LQ+AL        E++   +    V  L  + +   
Sbjct: 1169 EQQPGNQAQA----QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224

Query: 1654 --FQKGELNVQISER--------------KTQLT--LIKQEIEKEEENLQVVLRQMSKHK 1695
              F++G L   +S                KTQ T  +++ +++K EE L     + S+  
Sbjct: 1225 SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284

Query: 1696 TELKNI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKG 1752
            TEL+++   L   Q E  + +G +   +  + EL +T +A L+ +L    LQ++  Q + 
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGER 1343

Query: 1753 EI-EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLA 1811
            E+ +  K+ L      ++    E+RA  S    L ++    +    +  +++   +    
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403

Query: 1812 AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE 1871
            A +E  +++ +  + L+ N+  L Q L +   +  +L   I  +++Q + ++ A+  L  
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSL 1463

Query: 1872 ELANVQDHLNLAKQDLLHTTKHQDVL----LSEQTRLQKDISEWANRFEDCQKEEETKQQ 1927
            +L      ++L ++ +    K + VL    ++ Q R QK ++    +  + +K+ ET++ 
Sbjct: 1464 DLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK-LTVQREQIRELEKDRETQRN 1522

Query: 1928 QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE------KE 1981
             L+    E+E+    +  Q    Q L+K+  +    LE   + L+E  H++E      KE
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVT----LECLALELEENHHKMECQQKLIKE 1578

Query: 1982 LTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE 2040
            L  Q+      L+ + L  EER + LQ +      LE   +   R+L ER+Q++  +  +
Sbjct: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638

Query: 2041 LLALQKEADSMRAD--------------FSLLRNQFLTERKKAEKQVASLKEALK----- 2081
            +  LQ++ + +  D                +L +Q   + K  E+ +  +K +L+     
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698

Query: 2082 --IQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQ 2139
               QR  +++   E K  +   +  +  ++L+ +D  +      + ++++Q    ELK Q
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ----ELKDQ 1754

Query: 2140 MANQKD------------LERRQMEISDAMRTL-----KSEVKDE-IRTSLKNLNQFLPE 2181
            +  Q              L +R+ EI    + L     + E+K++ +++ L    + L +
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814

Query: 2182 LPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKL 2241
               +LEA+ +  +  +G+ E +KE       +G  E+    + + + + H   +  +E+ 
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADAL--QGALEQ----AHMTLKERHGELQDHKEQA 1868

Query: 2242 RHREDRLKAQLRHCMSKQAEV--LIKGKRQTEGTLHSLRRQVDALG---ELVTSTSADS- 2295
            R  E+ L  + R   + +  +  L    R+ E  L +L++Q        E+ T    DS 
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928

Query: 2296 ----ASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
                A      Q   +L  +SQ  ++QE+ A AR
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962



 Score =  152 bits (383), Expect = 5e-36
 Identities = 220/1014 (21%), Positives = 429/1014 (42%), Gaps = 92/1014 (9%)

Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKR 1387
            ++D+ Q L   +     ++    Q E+E + L   +  L  E+ +L  +  +L   V   
Sbjct: 402  VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461

Query: 1388 QQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIECIEKTLLKRRSELREADRLL 1442
             ++++ +    E L  +LE+ +       + + ++  + +  +    +++ EL  A R  
Sbjct: 462  SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521

Query: 1443 AEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQ 1502
               +  L   + K   ++ +    + +L  +  + E L +   E    L +A+Q +  L 
Sbjct: 522  ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581

Query: 1503 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
            +    L+           +++ +  A   D   L+++  +L EE Q +   +E AE+  +
Sbjct: 582  SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
                 L E+E   +A   +   L++Q+   ++  A L   L   +EE   +Q  + +++ 
Sbjct: 642  ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701

Query: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1682
              QEA        T +   + +     EE+  +  +    +   K  L +  Q +E++ +
Sbjct: 702  Q-QEA-------ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753

Query: 1683 NLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE----KL 1738
            +L   L+ +S  K  L++ L   Q +N  ++  K Q + ++  + + +  +  E    KL
Sbjct: 754  DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKL 813

Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
            EL+  +  ++Q++     Q    E++ +          AL+       KE   L+EK   
Sbjct: 814  ELDTERSQAEQERDAAARQLAQAEQEGK---------TALEQQKAAHEKEVNQLREK--- 861

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
            WEK+ +  ++ LA A E+ + E+  LE + L  ++ + E  Q  R++     + +  Q Q
Sbjct: 862  WEKERSWHQQELAKALESLEREKMELE-MRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920

Query: 1859 LQEKREAVNSL------QEELANVQDHLNLAKQDL-LHTTKHQDVLLSEQTRL---QKDI 1908
            L+ ++E V+ L      Q+ELA+    L   +QD+ +   K Q+     QT+L   Q+++
Sbjct: 921  LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL 980

Query: 1909 SEWANRFED----CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
             E A +  D     Q+E  +  Q    LQ ++E+ K +LV Q+   QRL  E+E +E   
Sbjct: 981  KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS-QRL-VEQEVQEKLR 1038

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTK 2024
            ET      ++ ++++KEL  +K+ L   L   +  E+R+  LQE +      ++ LS  +
Sbjct: 1039 ET------QEYNRIQKELEREKASLTLSL---MEKEQRLLVLQEAD---SIRQQELSALR 1086

Query: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKA--------------E 2070
            + + E + +  E S ++  L++E     ADF     Q L E + +              E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146

Query: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSC-IQKEMATIELVAQDNHERARRLMKELN-- 2127
             + A L+  L+   SQLE    EQ+  N    Q ++A++    Q           EL+  
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206

Query: 2128 -QMQYEYTELKKQMANQKDLERR--------QMEISDAMRTLKSEV--KDEIRTSLKNLN 2176
                     L+      + L +R           ++ A+  L  ++    + R  L++  
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQV 1266

Query: 2177 QFLPELPADLEAILERNENLEGELESLKENLPFTMNE-GPFEEKLNFSQVHIMDEHWRGE 2235
            Q L E   D EA       +  EL+ L+  L     E   +E K N  +  +M+ H    
Sbjct: 1267 QKLEERLTDTEA---EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA 1323

Query: 2236 ALREKLRHRE-DRLKAQ-LRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGEL 2287
            +L+ +LR  E  R++AQ  R  +    E L       +  +   R Q  A G L
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGIL 1377



 Score =  150 bits (380), Expect = 1e-35
 Identities = 197/986 (19%), Positives = 415/986 (42%), Gaps = 103/986 (10%)

Query: 1325 VSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTV 1384
            +S L  + + L+S   E   +R  + +    +     +I +L   + +L+ EV +L    
Sbjct: 539  LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598

Query: 1385 QKRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLA 1443
             K     + +  +   L  +L ++E+    ++ +   +E  E+     + +L EA++   
Sbjct: 599  VKLSALNEALALDKVGLNQQLLQLEEE---NQSVCSRMEAAEQARNALQVDLAEAEKRRE 655

Query: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 1503
                + +  + + + A E   + +  L   + + EE++++  E+      A  QL  L  
Sbjct: 656  ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715

Query: 1504 DAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE----- 1558
            +AK  E+   +  +  + + +  AA +   Q + + ++ L E+LQ L    E+ E     
Sbjct: 716  EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775

Query: 1559 -RNEDHHLQVLK-ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
             + ++  ++V K + EV +Q      E ++ +V   + E   LD +    ++E       
Sbjct: 776  AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE---LDTERSQAEQERDAAARQ 832

Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLE----ELSFQKGELNVQISERKTQLTL 1672
            + QA+ + + AL        +K  H +EV  L E    E S+ + EL   +   + +   
Sbjct: 833  LAQAEQEGKTALE------QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886

Query: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELE---KT 1729
            ++  +++++  ++ +  Q  + +T+ ++ L  +QLE  +         +RVS LE   +T
Sbjct: 887  LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK---------ERVSLLETLLQT 937

Query: 1730 QVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE-SRALQSCVECLSKE 1788
            Q  + +   +LE L+Q  + QK + +    +L+   +E +R   E +R  +  +  L +E
Sbjct: 938  QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997

Query: 1789 KED-LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLS 1847
                LQ+K D+ +K++   K  L A +++ ++       +E  V++  +E  + NR +  
Sbjct: 998  SSSLLQDKMDL-QKQVEDLKSQLVAQDDSQRL-------VEQEVQEKLRETQEYNRIQKE 1049

Query: 1848 LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1907
            L  + +++   L EK + +  LQE  +  Q  L+  +QD+                    
Sbjct: 1050 LEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM-------------------- 1089

Query: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETS 1967
                    ++ Q E++    Q+++L+ E++E +   + QE       +     E +L  S
Sbjct: 1090 --------QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRAS 1141

Query: 1968 KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
                + +  QL+  L   +S+L+      LAAE++     + +    SL   L Q    +
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLE-----ALAAEQQPGNQAQAQAQLASLYSALQQALGSV 1196

Query: 2028 SEREQQLV---EKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR 2084
             E   +L    + +  +  L+ + +  R+ F   R   LT         A  K    + +
Sbjct: 1197 CESRPELSGGGDSAPSVWGLEPDQNGARSLFK--RGPLLTALSAEAVASALHKLHQDLWK 1254

Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQK 2144
            +Q  +++L  + +   +++ +   E      H   + L ++L+Q Q    E  K    Q 
Sbjct: 1255 TQQTRDVLRDQVQK--LEERLTDTEAEKSQVHTELQDLQRQLSQNQ---EEKSKWEGKQN 1309

Query: 2145 DLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLK 2204
             LE   ME+ + M +L+S ++   R  L+ +     E   + E +    ENL  ++E L+
Sbjct: 1310 SLESELMELHETMASLQSRLR---RAELQRM-----EAQGERELLQAAKENLTAQVEHLQ 1361

Query: 2205 ----ENLPFTMNEGPFEEKLNF--SQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
                E        G  EE L    S + + +E    E  R +    +  LK      + +
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421

Query: 2259 QAEVLIKGKRQTEGTLHSLRRQVDAL 2284
               +L +   + E  + +LR Q+  L
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQEL 1447



 Score =  135 bits (340), Expect = 5e-31
 Identities = 226/1077 (20%), Positives = 459/1077 (42%), Gaps = 109/1077 (10%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            E  NL+  + RLE+  Q  +S       +R    +++   + L  +++ L  +       
Sbjct: 92   EEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR-- 149

Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIE--------- 1422
             +EL R   + Q +++F  G ++     L     E+    +H  ++    +         
Sbjct: 150  -DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAE 208

Query: 1423 -----------CIEKTLLKRRSELREADRLLAEAESEL----SCTKEKTKNAVEKFTDAK 1467
                       C+  T+  +  E   + R+     ++L    + T+E  K A E+  +  
Sbjct: 209  HVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI 268

Query: 1468 RSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
            +   Q + +  EL+ R  E +  L ++ +Q    +   K L +      EIL E N    
Sbjct: 269  QLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE----TVEIL-ETNHTEL 323

Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIE--MAERNED------HHLQVLKESEVLLQAKR 1579
             +       + ++EKL+  LQ++ KDI   M E  ++      H   +  +S +  Q   
Sbjct: 324  MEHEASLSRNAQEEKLS--LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDY 381

Query: 1580 AELEK----LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD---LQEALRLGE 1632
             + +K    ++S +T ++Q +  L +QL   +E ++LLQ    Q + +   L++ L+   
Sbjct: 382  QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441

Query: 1633 TEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE---IEKEEENLQVVLR 1689
             E         +++  ++ LS ++  L     E + QL +++QE   + +    LQ+   
Sbjct: 442  GERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD 501

Query: 1690 QMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ-QISQ 1748
                 K E +  L +   E   LQ + +  + + SE   +++  L E LE  +L+ ++ +
Sbjct: 502  SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-SLSELITLREALESSHLEGELLR 560

Query: 1749 QQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKR 1808
            Q++ E+      L R ++ I  +++    L++ V  L      L    +          +
Sbjct: 561  QEQTEV---TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQ 617

Query: 1809 VLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNS 1868
             L   EE ++   S +E  E     LQ +L +  + + +L    + ++ QLQ+  EA   
Sbjct: 618  QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677

Query: 1869 LQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET---K 1925
            LQ +L ++Q+     ++ L  +   Q+   ++  +L ++            +E+E    +
Sbjct: 678  LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVRE 737

Query: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQ 1985
            +  L+V    +E ++  L +Q    Q L   +E  ES L       + QQ     E+T  
Sbjct: 738  KAALEVRLQAVERDRQDLAEQ---LQGLSSAKELLESSL------FEAQQQNSVIEVT-- 786

Query: 1986 KSKLDQVLSKVLAAEERVRTLQEEERWCE---SLEKTLSQTKRQLSEREQQLVEKSGELL 2042
            K +L+  +  V  A+E    +Q E R  +     E++ ++ +R  + R+    E+ G+  
Sbjct: 787  KGQLEVQIQTVTQAKE---VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK-T 842

Query: 2043 ALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCI- 2101
            AL+++  +   + + LR ++  ER   ++++A   E+L+ ++ +LE  L EQ+ E   I 
Sbjct: 843  ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902

Query: 2102 --------QKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM----ANQKDLERR 2149
                    Q E A  ++  +   ER   L++ L Q Q E  +  +Q+     + K  + +
Sbjct: 903  AQREEERTQAESALCQMQLETEKERV-SLLETLLQTQKELADASQQLERLRQDMKVQKLK 961

Query: 2150 QMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENL-- 2207
            + E +  ++T   E + E++ + +     L  L  +  ++L+   +L+ ++E LK  L  
Sbjct: 962  EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021

Query: 2208 ---PFTMNEGPFEEKLNFSQVH--IMDEHWRGEA-LREKLRHREDRLKAQLRHCMSKQAE 2261
                  + E   +EKL  +Q +  I  E  R +A L   L  +E RL         +Q E
Sbjct: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081

Query: 2262 V--LIKGKRQTEGTLHSLRRQVDALGELVTSTSAD--SASSPSLSQLESSLTEDSQL 2314
            +  L +  ++ +G    L  Q++ L + V    AD  +  +  L +LE+S   + QL
Sbjct: 1082 LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138



 Score =  124 bits (310), Expect = 1e-27
 Identities = 226/961 (23%), Positives = 400/961 (41%), Gaps = 144/961 (14%)

Query: 232  TLPHYLQFTIFHLRSL-----ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
            TL   LQ  +   RS      + LE        R E  E  +L+E+  L R LE++    
Sbjct: 54   TLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDEL--LVR-LEEEQQRC 110

Query: 287  EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRAC 346
            E L    T+    ++  D +NK+L+E+        E+L  D +   + L +K        
Sbjct: 111  ESLAEVNTQLRLHMEKADVVNKALREDV-------EKLTVDWSRARDELMRK-------- 155

Query: 347  QKQYELEQELAFYKIDAKFE---------PLNYYPSEYAEIDKAPDESPYIGKSRYKRNM 397
            + Q+++EQE  F+K   K E          +  +   + E+  A D      K+ + R  
Sbjct: 156  ESQWQMEQE--FFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLS 213

Query: 398  FATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELH 457
             +  +  +      Q +  EP+   R D         L  + ++ EK+       L +L 
Sbjct: 214  GSLLTCCLRLTVGAQSR--EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLK 271

Query: 458  DE--IEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDL 515
             +  +EKAE Q     +   +L   +   +      + + K L   ++++     E ++ 
Sbjct: 272  SQGDLEKAELQ-----DRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEH 326

Query: 516  ELQMEKQKQEIA-GKQKEIKDL-QIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK---- 569
            E  + +  QE     Q+ IKD+ Q+ ++  D+         AQ SG E  L++ +     
Sbjct: 327  EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI--------AQGSGHENSLELDSSIFSQ 378

Query: 570  -QYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN------EALKKDLEGVISGLQ 622
              YQ  +  L  + S + +  + ++DL +QL   Q A N      +  +++ + +   LQ
Sbjct: 379  FDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ 438

Query: 623  EYLG---TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAE 679
            +  G   T+ GQ    Q E   L  E+E LLQ+    E+ R QLE++  +A  +R+   E
Sbjct: 439  KLTGERDTLAGQTVDLQGEVDSLSKERE-LLQKAR--EELRQQLEVLEQEAWRLRRVNVE 495

Query: 680  L----ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
            L    +SA  ++ E     QQ +  L+  E E    + L   EA Q +   E +T    L
Sbjct: 496  LQLQGDSAQGQKEE-----QQEELHLAVRERERLQEM-LMGLEAKQSESLSELITLREAL 549

Query: 736  EQSALQAELEKERQA-LKNALGKAQ--FSEEKEQENS-------------ELHAKLKHLQ 779
            E S L+ EL ++ Q  +  AL +A+   +E    EN+             +L A  + L 
Sbjct: 550  ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609

Query: 780  DDNNLLKQQLKDFQNHLNHVVDGLVRPEEV--AARVDELR-RKLKLGTGEMNIHSPSDV- 835
             D   L QQL   +     V   +   E+   A +VD     K +    E N H  + + 
Sbjct: 610  LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQ 669

Query: 836  --------LGKSLADLQKQFSEI---LARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
                    L   L D+Q++  EI   L+ S+ +++ A  +  +L +E   Q+E LA   +
Sbjct: 670  KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729

Query: 885  EFRQACER---ALEARMNFDKRQHEARIQQ----------MENEIHYLQENLKSMEEIQG 931
            E ++A  R   ALE R+   +R  +   +Q          +E+ +   Q+    +E  +G
Sbjct: 730  E-KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788

Query: 932  LTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 991
              ++Q+Q   + KE I  ++R L+ +   E ++++++           + A A     A 
Sbjct: 789  QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE-----------RDAAARQLAQAE 837

Query: 992  AELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIE--LLQNL 1049
             E   A +Q K+ H    ++NQ R +  +E     ++ A+A   L R + E+E  L +  
Sbjct: 838  QEGKTALEQQKAAH--EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895

Query: 1050 LRQKGEQFRLEMEKTGVGTGANSQVLEIEK----LNETMERQRTEIARLQNVLDLTGSDN 1105
               +  Q + E E+T   +      LE EK    L ET+ + + E+A     L+    D 
Sbjct: 896  TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955

Query: 1106 K 1106
            K
Sbjct: 956  K 956



 Score =  116 bits (290), Expect = 3e-25
 Identities = 220/1048 (20%), Positives = 436/1048 (41%), Gaps = 147/1048 (14%)

Query: 88   IKKLTKQDNL--ALIKSLNLSLSKDGGK---KFKYIENLEKCVKLEVLNLSYNLIGKIEK 142
            I++L KQ  +  A ++ L+L L K   +   + + I+ LEKC  +            +E 
Sbjct: 1444 IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV------------LEH 1491

Query: 143  LDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKG 202
            L   ++ RE  L+  +  +I  +E     Q+     N +EH  + L KK + +       
Sbjct: 1492 LPMAVQEREQKLTVQR-EQIRELEKDRETQR-----NVLEHQLLELEKKDQMIE------ 1539

Query: 203  NKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQE 262
            ++   +QD+ K     + ++L L EN      H ++      + ++ LEGQ  T   ++ 
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENH-----HKMEC---QQKLIKELEGQRET---QRV 1588

Query: 263  AFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
            A    +L+  ER  ++L+ +  +  +L+S  T    E++ +D+  KS +E+    ++  E
Sbjct: 1589 ALTHLTLDLEER-SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE 1647

Query: 323  ELKSDLNTKN-ELLKQK----TIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE 377
             L  DL  ++ EL+ QK     +E  R  Q +  LE++L   K+  +             
Sbjct: 1648 HLTQDLERRDQELMLQKERIQVLEDQRTRQTKI-LEEDLEQIKLSLRERGRELTTQRQLM 1706

Query: 378  IDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDT 437
             ++A +     G S+ +R        I+   +    K++E  ++  ++   L+    L+ 
Sbjct: 1707 QERAEEGK---GPSKAQRGSLEHMKLILRDKE----KEVECQQEHIHELQELKDQ--LEQ 1757

Query: 438  QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
            QL+   +K+      LS+   EI   +QQ+  A E+ +  E+++Q  ++ EA      + 
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ-SQLDEA-----QRA 1811

Query: 498  LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 557
            L+ R Q +  L+QE    + Q E+ K++    Q  ++   + +     +   H   K Q 
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH---KEQA 1868

Query: 558  SGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 617
               E++L +  ++ Q LE  L ++ +   ++ + +  L++Q  E      +A + ++E  
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE------QAQEHEVE-- 1920

Query: 618  ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
                      ++    QAQ   ++   E E L     E +  R Q E     AE +++ L
Sbjct: 1921 -------TRALQDSWLQAQAVLKERDQELEALR---AESQSSRHQEEAARARAEALQEAL 1970

Query: 678  AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
             +  +ALQ + +      +    L A  A L+A L+   A + QL+E L    R+ + E 
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL----RIQEGEI 2026

Query: 738  SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN 797
                   +++ Q L+ AL +       +QE  +L  K    +   N+++++    QN   
Sbjct: 2027 QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEK----QNL-- 2080

Query: 798  HVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE 857
                G  R EE    + +  R+L+L                +LA  +++  E+    +  
Sbjct: 2081 ----GQEREEEEIRGLHQSVRELQL----------------TLAQKEQEILELRETQQRN 2120

Query: 858  RDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEAR--IQQMENE 915
              EA     K    M  Q  KL + +   ++  ER   A    + R+ E R   Q +   
Sbjct: 2121 NLEALPHSHK-TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179

Query: 916  IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975
            +   + ++ S++E+       + E D E++R+  +L EL ++              L+KE
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL-ELTRR-------------ALEKE 2225

Query: 976  LKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035
                  A +T++  +  E  +   ++  +         E+    Q  E   +  A+   D
Sbjct: 2226 RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID 2285

Query: 1036 LTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQ 1095
             +R +     L++ L Q  E+ R ++++  +   A +  LEI K   +   Q+       
Sbjct: 2286 RSRLQRHNVQLRSTLEQV-ERERRKLKREAM-RAAQAGSLEISKATASSPTQQ------- 2336

Query: 1096 NVLDLTGSDNKGGFENVLEEIAELRREV 1123
                    D +G   +  + +AEL++EV
Sbjct: 2337 --------DGRGQKNSDAKCVAELQKEV 2356



 Score =  111 bits (278), Expect = 7e-24
 Identities = 181/776 (23%), Positives = 333/776 (42%), Gaps = 123/776 (15%)

Query: 1336 KSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFID 1395
            K+++     M+   R  EKE+E    +I +L + K  LE +++ LHR V           
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV----------- 1766

Query: 1396 GNVESLMT--ELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTK 1453
            G    L++  E EI    +  ++  ++ E  E++L   +S+L EA R LA+ + EL   +
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL---QSQLDEAQRALAQRDQELEALQ 1823

Query: 1454 EKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKD-LEQHK 1512
            ++ +              Q +   E ++ +A      L +A   L+    + +D  EQ +
Sbjct: 1824 QEQQ--------------QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR 1869

Query: 1513 IKQEEILKEINKIVAAKD--SDFQCLSKKKEKLTEELQKLQKDIEMAERNE-------DH 1563
              +EE+  E  ++ A ++   D +  S+++EK    LQ  Q+  E A+ +E       D 
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ--QQCAEQAQEHEVETRALQDS 1927

Query: 1564 HLQ---VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH-----KKEELHLLQG 1615
             LQ   VLKE +  L+A RAE +  + Q  + +     L   LG      + +E HLL+ 
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ 1987

Query: 1616 S-----------MVQAKAD--------LQEALRLGETEVTEK-CNHIREVKSLLEELSFQ 1655
            +            +QA  D        L+EALR+ E E+ ++   +  +V+ L + L+ +
Sbjct: 1988 AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR 2047

Query: 1656 KGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
              EL  Q  + + QL L K   ++ +EN+    + + + + E +  +  L     ELQ  
Sbjct: 2048 DEELRHQ--QEREQL-LEKSLAQRVQENMIQEKQNLGQEREEEE--IRGLHQSVRELQLT 2102

Query: 1716 KLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAES 1775
              Q +Q + EL +TQ        +  NL+ +    K     ++Q L+ D  E  R+  E 
Sbjct: 2103 LAQKEQEILELRETQ--------QRNNLEALPHSHKTS-PMEEQSLKLDSLE-PRLQREL 2152

Query: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQ 1835
              LQ+ +      + + +EK       LAQTK  +++ +E +   Q+++ + +   ++LQ
Sbjct: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ 2212

Query: 1836 QELDQLNR--DKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1893
             EL+   R  +K  LH+  +    +L  + E    L  E++ V+                
Sbjct: 2213 DELELTRRALEKERLHSPGATSTAELGSRGEQGVQL-GEVSGVE---------------- 2255

Query: 1894 QDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRL 1953
                 +E +    +   W  R E  Q+     +     LQ    + +  L Q E   ++L
Sbjct: 2256 -----AEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310

Query: 1954 QKE--RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER 2011
            ++E  R ++   LE SK T      Q  +   +  +K    L K +   +   TL+ +++
Sbjct: 2311 KREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQK 2370

Query: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK-------EADSMRADFSLLRN 2060
              +      +QT R+L+     L   S  LLA+ +       EA++ R D SL ++
Sbjct: 2371 --QDYITRSAQTSRELAGLHHSL---SHSLLAVAQAPEATVLEAETRRLDESLTQS 2421



 Score =  106 bits (265), Expect = 2e-22
 Identities = 198/950 (20%), Positives = 388/950 (40%), Gaps = 145/950 (15%)

Query: 269  LEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDL 328
            +E    L R+ +++ +  +++    T+ +  ++  D + +    E  L+  S    + D 
Sbjct: 324  MEHEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHENSLELDSSIFSQFDY 381

Query: 329  NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
               ++ L      LTR  Q   +L Q+LA  +     E +N    ++ + ++        
Sbjct: 382  QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ-----EAVNLLQQQHDQWEEE------- 429

Query: 389  GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKI-- 446
            GK+  +R    T      + Q V ++  E D   +   +  +    L  QLE  E++   
Sbjct: 430  GKALRQRLQKLTGERDTLAGQTVDLQG-EVDSLSKERELLQKAREELRQQLEVLEQEAWR 488

Query: 447  ------------SAAQTRLSELHDEIEKAEQQILRATE-----EFKQLEEAIQLKKISEA 489
                         +AQ +  E  +E+  A ++  R  E     E KQ E   +L  + EA
Sbjct: 489  LRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA 548

Query: 490  GKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPK 549
               L    L G L     LRQE  ++   + + +Q IA        L+  +  L +   K
Sbjct: 549  ---LESSHLEGEL-----LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600

Query: 550  HSHMKA----QKSGKEQQLDIMNKQYQQLESRLDEI----------LSRIAKETEEIKD- 594
             S +       K G  QQL  + ++ Q + SR++            L+   K  E + + 
Sbjct: 601  LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660

Query: 595  ---LEEQLTEGQIAANE--ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE---- 645
               LE QL + + A  E  A  +D++     +Q+ L   + Q   A  +  +L  E    
Sbjct: 661  NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720

Query: 646  KETLLQRLTEVE---QERDQLEIVAMDAENMRKELAE-----------LESALQEQHEVN 691
            +E L + + E E   +E+  LE+     E  R++LAE           LES+L E  + N
Sbjct: 721  EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780

Query: 692  ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL 751
            + ++ T+G L      +     +   E   LK EL+      + E+ A   +L +  Q  
Sbjct: 781  SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG 840

Query: 752  KNALGKAQFSEEK---------EQENS----ELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
            K AL + + + EK         E+E S    EL   L+ L+ +   L+ +LK+ Q  +  
Sbjct: 841  KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM-- 898

Query: 799  VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSD--VLGKSLADLQKQFSEILARSKW 856
                    E + A+ +E R + +    +M + +  +   L ++L   QK+ ++   + + 
Sbjct: 899  --------EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER 950

Query: 857  ERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENE- 915
             R + +V++ K QE   + Q +L   Q E ++A             RQH   +  ++ E 
Sbjct: 951  LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA------------RQHRDDLAALQEES 998

Query: 916  IHYLQENLKSMEEIQGLTDLQLQEADEEK---ERILAQLRELEK----KKKLEDAKSQEQ 968
               LQ+ +   ++++ L    + + D ++   + +  +LRE ++    +K+LE  K+   
Sbjct: 999  SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058

Query: 969  VFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE----RAEELQEAER 1024
            +  ++KE + L   +  +D +   EL+  +  ++   G   +++ +    R E  ++   
Sbjct: 1059 LSLMEKEQRLL--VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116

Query: 1025 FSRKAAQAARDLTRAE-AEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
            F  + AQ   +L  +   E +L  +L  Q+ +  +L++      T +  + L  E+    
Sbjct: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR--STESQLEALAAEQQPGN 1174

Query: 1084 MERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
              + + ++A L + L           +  L  + E R E+S   D   S+
Sbjct: 1175 QAQAQAQLASLYSAL-----------QQALGSVCESRPELSGGGDSAPSV 1213



 Score =  104 bits (259), Expect = 1e-21
 Identities = 172/925 (18%), Positives = 376/925 (40%), Gaps = 154/925 (16%)

Query: 245  RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQD 304
            + +E L+ Q V   D Q             +E+++++K+ ET+E    Q   LE  K   
Sbjct: 1010 KQVEDLKSQLVAQDDSQRL-----------VEQEVQEKLRETQEYNRIQKE-LEREKASL 1057

Query: 305  KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
             L+   KE+ +L  Q  + ++     +   L+Q   ++  A  +Q EL  ++   + + K
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQ---ELSALRQ---DMQEAQGEQKELSAQMELLRQEVK 1111

Query: 365  FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
             +  ++   E   +++   E+ +I + + + +++A E+     A  +Q++    + QL  
Sbjct: 1112 EKEADFLAQEAQLLEEL--EASHITEQQLRASLWAQEA----KAAQLQLRLRSTESQLEA 1165

Query: 425  DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ-- 482
                           E +    + AQ +L+ L+  +++A   +  +  E     ++    
Sbjct: 1166 ------------LAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213

Query: 483  ---------LKKISEAGKDLLYKQLSGRLQLVNKLRQEALD-------LELQMEKQKQEI 526
                      + + + G  L           ++KL Q+          L  Q++K ++ +
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273

Query: 527  AGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIA 586
               + E   +   +  L  +  ++   K++  GK+  L+    +  +L   +  + SR+ 
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE---SELMELHETMASLQSRLR 1330

Query: 587  KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
            +      +L+    +G+    +A K++L   +  LQ  +   + QA+ A      LR  +
Sbjct: 1331 RA-----ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTAR 1385

Query: 647  ETLLQRLTEVEQER-------DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQG 699
              L  +  EVE ER       +Q E+     + +++ LA L   L E+ E    ++  +G
Sbjct: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE---EVETLRG 1442

Query: 700  DLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQ 759
             +     ELE +  ++ A    L  +L+K  +   L+Q  +Q ELEK R  L++     Q
Sbjct: 1443 QIQ----ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ-ELEKCRSVLEHLPMAVQ 1497

Query: 760  FSEEKEQENSELHAKLKHLQDD----NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDE 815
               E+EQ+ +    +++ L+ D     N+L+ QL + +       D ++  E    +V +
Sbjct: 1498 ---EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK-----DQMI--ESQRGQVQD 1547

Query: 816  LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQ 875
            L+++L                            E LA    E       ++KL +E+  Q
Sbjct: 1548 LKKQLVT-------------------------LECLALELEENHHKMECQQKLIKELEGQ 1582

Query: 876  QEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDL 935
            +E             +R     +  D  +    +Q   ++IH L+ +   +         
Sbjct: 1583 RE------------TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR------- 1623

Query: 936  QLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELT 995
            +LQE D+E +    Q+ EL+++K+       + +   D+EL   K+ +   +   T +  
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKE----HLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679

Query: 996  IAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE-AEIELLQNLLRQKG 1054
            I ++ L+ +  ++    +ER  EL    +  ++ A+  +  ++A+   +E ++ +LR K 
Sbjct: 1680 ILEEDLEQIKLSL----RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735

Query: 1055 EQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLE 1114
            ++   + E           + E+++L + +E+Q   + R      L  S  +     + +
Sbjct: 1736 KEVECQQE----------HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785

Query: 1115 EIAELRREVSYQNDYISSMADPFKR 1139
            ++ E R +   +   + S  D  +R
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQR 1810



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 71/340 (20%), Positives = 141/340 (41%), Gaps = 56/340 (16%)

Query: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQ 1985
            ++Q+  LQ ++ EN+    ++    Q  Q+ + +   KL+   +  +    +LEK L   
Sbjct: 21   EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80

Query: 1986 KSKLDQVLSKVLA--AEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLA 2043
               + Q    V     +E +  L+EE++ CESL +    T+ +L   +  +V K     A
Sbjct: 81   GGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEV--NTQLRLHMEKADVVNK-----A 133

Query: 2044 LQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQL---------------- 2087
            L+++ + +  D+S  R++ + +  + + +    K  LK +  +L                
Sbjct: 134  LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193

Query: 2088 -----EKNLLEQKQENSCIQKEMAT----IELVAQDNHERARRLMKELNQMQYEYTELKK 2138
                 +++L+E K E+  +   + T    + + AQ         M        E  +L  
Sbjct: 194  MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-----GREPAQLLL 248

Query: 2139 QMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG 2198
             +A  ++LE+   E S  +  LKS+   E       L   + EL A L    ++NE+ E 
Sbjct: 249  LLAKTQELEKEAHERSQELIQLKSQGDLE----KAELQDRVTELSALLTQSQKQNEDYEK 304

Query: 2199 ELESLKENLPF-------------TMNEGPFEEKLNFSQV 2225
             +++L+E +               +++    EEKL+  QV
Sbjct: 305  MIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV 344



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 55/268 (20%), Positives = 117/268 (43%), Gaps = 13/268 (4%)

Query: 1963 KLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEER----VRTLQEE----ERWCE 2014
            K ++ ++ L+EQ   L++++ + ++   + L     A++R    VR LQ +      WC+
Sbjct: 12   KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ 71

Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD-FSLLRNQFLTERKKAEKQV 2073
             LEK L  T   + +R + + E + + L ++ E +  R +  + +  Q     +KA+   
Sbjct: 72   ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
             +L+E ++       +   E  ++ S  Q E    +   +  H R   L +E+   +  +
Sbjct: 132  KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191

Query: 2134 TELKKQM-ANQKDLERRQMEISDAMRT--LKSEVKDEIRTSLKNLNQFLPELPADLEAIL 2190
             E+K     +  +L+   + +S ++ T  L+  V  + R       +     PA L  +L
Sbjct: 192  LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP-NGSGRMDGREPAQLLLLL 250

Query: 2191 ERNENLEGELESLKENLPFTMNEGPFEE 2218
             + + LE E     + L    ++G  E+
Sbjct: 251  AKTQELEKEAHERSQELIQLKSQGDLEK 278


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  180 bits (457), Expect = 1e-44
 Identities = 234/1067 (21%), Positives = 463/1067 (43%), Gaps = 143/1067 (13%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD----------- 1365
            +H  L  E + L + +Q       E   MRA     ++E+EE+ H+++            
Sbjct: 881  KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI 940

Query: 1366 LLQEKKSLECEVEELHRTV-------QKRQQQKDFIDGNV-----ESLMTELEIEKSLKH 1413
            L  EKK ++  +++L   +       QK Q +K   +  +     E L+ E +  K +K 
Sbjct: 941  LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000

Query: 1414 HEDIVDEI-ECI-----EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAK 1467
             + + D I EC      E+   K  +++R    ++     E    +EKT+  +EK   AK
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK---AK 1057

Query: 1468 RSLLQTESDAE----ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEIN 1523
            R L    +D +    EL+ +  E  + L K +++L+   A   D   HK    ++++E+ 
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117

Query: 1524 KIVAAKDSDFQC-------LSKKKEKLTEELQKLQKDIE--MAERNEDHHLQVLKESEV- 1573
              +A    DF+          K+K  L+EEL+ L+ ++E  +        L+  +E EV 
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177

Query: 1574 -LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
             L +A   E +  ++Q+   +Q  A    +L  + E+    + ++ + K  L       E
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL-------E 1230

Query: 1633 TEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVL-RQM 1691
            T+  E    ++ ++ +  E   ++ +L+ Q+ E   +++        E + L+V L  + 
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS--------EGDRLRVELAEKA 1282

Query: 1692 SKHKTELKNILDMLQLENHELQGLKLQHD--QRVSELEKTQVAVLEE---KLELENLQQI 1746
            SK + EL N+  +  LE  E +G+K   D     S+L+ TQ  + EE   KL L +  + 
Sbjct: 1283 SKLQNELDNVSTL--LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340

Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED---LQEKCDIWEKKL 1803
             +++K  ++ Q++  E  ++ +E+      ALQS +    K+ +D     E  +  +KKL
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVL---ALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397

Query: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
             +    L+   E   +    LEK +    +LQQELD L  D              L  +R
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTK---NRLQQELDDLTVD--------------LDHQR 1440

Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
            +  ++L+++                   K  D LL+E+  +    +E  +R E   +E+E
Sbjct: 1441 QVASNLEKK------------------QKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482

Query: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELT 1983
            TK   L     E  E K +       F+R  K+  ++   L +SK  + +  H+LEK   
Sbjct: 1483 TKALSLARALEEALEAKEE-------FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535

Query: 1984 DQKSKLDQVLSKVLAAEERVRTLQEEERWCE-SLEKTLSQTKRQLSEREQQLVEKSGELL 2042
              + +++++ +++   E+ ++  ++ +   E +++   +Q +R L  R++Q  EK   L+
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595

Query: 2043 ALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK---EALKIQRSQLEKNLLEQKQENS 2099
               +E ++   D    R   +  +KK E  +  L+   EA    R ++ K L + + +  
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 2100 CIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT 2159
              Q+E+        +   +++   K+L  ++ E  +L++++A+ +   R   +  D    
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD---- 1711

Query: 2160 LKSEVKDEIRTSLKNLNQFLPE---LPADLEAILERNENLEGELESLKENLPFTMNEGPF 2216
               E+ DEI  S    +  L E   L A +  + E  E  +  +E L +    T  +   
Sbjct: 1712 ---ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ--- 1765

Query: 2217 EEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHS 2276
             + LN           + +  R++L  +   LKA+L     ++ E  +K K   + T+ +
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL-----QELEGAVKSK--FKATISA 1818

Query: 2277 LRRQVDALGELVTSTSADSASSPSL-SQLESSLTEDSQLGQNQEKNA 2322
            L  ++  L E +   + + A++  L  + E  L E     +++ ++A
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA 1865



 Score =  145 bits (365), Expect = 6e-34
 Identities = 225/969 (23%), Positives = 424/969 (43%), Gaps = 144/969 (14%)

Query: 1453 KEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS---LQADAKDLE 1509
            +E+ +   E+    K    + E + EE+ER+ Q+         +QL++   L A+A+++ 
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910

Query: 1510 QH----KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAER------ 1559
                  K + EEIL ++   V  ++   Q L  +K+K+   +Q L++ ++  E       
Sbjct: 911  ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970

Query: 1560 ----NEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
                  +  ++ ++E  +LL+ + ++  K K  +  +  E +    +   K + L  ++ 
Sbjct: 971  LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQ 1675
                  +DL+E  RL + E T      +E++    +L  +  +L  QI+E + Q+  +K 
Sbjct: 1031 KQEVMISDLEE--RLKKEEKTR-----QELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083

Query: 1676 EIEKEEENLQVVLRQ---MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
            ++ K+EE LQ  L +    + HK     ++  LQ +  ELQ          ++ EK +  
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143

Query: 1733 VLEE----KLELEN-LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
            + EE    K ELE+ L   + QQ+   + ++++ E  K   E        +Q   +  + 
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203

Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQ-------ELDQ 1840
              E+L E       +L Q KR  A  E+N +  +++ ++L   V+ LQQ       +  +
Sbjct: 1204 ALEELSE-------QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKH------- 1893
            L+     LH  +S   +   E  E  + LQ EL NV   L  A++  +   K        
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316

Query: 1894 -QDV--LLSEQTRLQKDIS-------EWANRFEDCQKEEETKQQQLQ----VLQNE---- 1935
             QD   LL E+TR + ++S       E  N  ++ Q+EEE  ++ L+     LQ++    
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376

Query: 1936 -------------IEENKLKLVQQ-EMMFQRLQKERESEESKLETSKVTLKEQ------- 1974
                         +EE K KL++  E + QRL+ E+     KLE +K  L+++       
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE-EKALAYDKLEKTKNRLQQELDDLTVD 1435

Query: 1975 ---QHQLEKELTDQKSKLDQVLSKVLA-----AEERVRTLQEEERWCESLEKTLSQTKRQ 2026
               Q Q+   L  ++ K DQ+L++  +     AEER R  + E R  E+   +L++   +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA-EAEAREKETKALSLARALEE 1494

Query: 2027 LSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQ 2086
              E +++   ++ +L A  ++  S + D     ++    ++  E+QV    E ++ Q  +
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV----EEMRTQLEE 1550

Query: 2087 LEKNLLEQKQENSCIQKEMATIELVAQ----------DNHERARRLMKELNQMQYEYTEL 2136
            LE  L  Q  E++ ++ E+    + AQ           N E+ R L+K++ +++ E  + 
Sbjct: 1551 LEDEL--QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608

Query: 2137 KKQMA-----------NQKDLE-------RRQMEISDAMRTLKSEVKDEIRTSLKNLNQF 2178
            +KQ A           + KDLE       + + E+   +R L++++KD  R  L+     
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR-ELEEARAS 1667

Query: 2179 LPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGE-AL 2237
              E+ A  +   ++ ++LE E+  L+E L  +       E+        +     G+ AL
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727

Query: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDAL-GELVTSTSADSA 2296
             ++ R  E R+         +Q+ + +   R  + TL     QVD L  EL    SA   
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL-----QVDTLNAELAAERSAAQK 1782

Query: 2297 SSPSLSQLE 2305
            S  +  QLE
Sbjct: 1783 SDNARQQLE 1791



 Score =  136 bits (342), Expect = 3e-31
 Identities = 192/874 (21%), Positives = 382/874 (43%), Gaps = 126/874 (14%)

Query: 1321 LENEVSRLEDIM------QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE 1374
            LE   + LED +      Q L++K+ +E  +   K+  E+E +     I D+ Q   +  
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQE--VAELKKALEEETKNHEAQIQDMRQRHATA- 1204

Query: 1375 CEVEELHRTVQKRQQQKDFIDGNVESLMTE-LEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
              +EEL   +++ ++ K  ++ N + L T+  E+   +K  + +  E E   K L  +  
Sbjct: 1205 --LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262

Query: 1434 ELR----EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
            EL     E DRL  E   + S  + +  N      +A++  ++   DA  LE + Q+T  
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322

Query: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
             L +  +Q  +L +  + LE+ K   +E  +E  +  A K+ + Q L+ + + L +  +K
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE--ARKNLEKQVLALQSQ-LADTKKK 1379

Query: 1550 LQKDIEMAERNEDHHLQVLKESEVL---LQAKRAELEKLKSQVTSQQQEMAVLDRQLGHK 1606
            +  D+   E  E+   ++LK++E L   L+ K    +KL+      QQE+  L   L H+
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439

Query: 1607 KEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 1666
            ++    L+    Q K D                  + E KS+    + ++     +  E+
Sbjct: 1440 RQVASNLEKK--QKKFD----------------QLLAEEKSISARYAEERDRAEAEAREK 1481

Query: 1667 KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQGLKLQHDQRV 1723
            +T+   + + +E+  E  +   RQ  + + ++++++   D +    HEL+  K   +Q+V
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541

Query: 1724 SELEKTQVAVLEE--------KLELE-NLQQISQQQKGEI-------EWQKQLLERDKRE 1767
             E+ +TQ+  LE+        KL LE N+Q +  Q + ++       E +K+LL +  RE
Sbjct: 1542 EEM-RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600

Query: 1768 IERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKL 1827
            +E    + R  Q  +   SK+K ++  K        AQ +    A +E  K     L KL
Sbjct: 1601 LEAELEDERK-QRALAVASKKKMEIDLK-----DLEAQIEAANKARDEVIKQ----LRKL 1650

Query: 1828 ELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD- 1886
            +  ++  Q+EL++    +  +       +++L+     +  LQEELA+ +     A+Q+ 
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710

Query: 1887 ------LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENK 1940
                  + ++   +  LL E+ RL+  I++        ++E E +Q  +++L +   +  
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQ-------LEEELEEEQSNMELLNDRFRKTT 1763

Query: 1941 LKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAE 2000
            L++         L  E  +E S  + S       + QLE++  + K+KL ++   V +  
Sbjct: 1764 LQV-------DTLNAELAAERSAAQKSD----NARQQLERQNKELKAKLQELEGAVKS-- 1810

Query: 2001 ERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRN 2060
                            + T+S  + ++ + E+QL +++ E  A  K           +  
Sbjct: 1811 --------------KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856

Query: 2061 QFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERAR 2120
            Q   ER+ A++    +++A   +  QL++ L E ++E              A   +   R
Sbjct: 1857 QVEDERRHADQYKEQMEKA-NARMKQLKRQLEEAEEE--------------ATRANASRR 1901

Query: 2121 RLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
            +L +EL+        L ++++  K+  RR   IS
Sbjct: 1902 KLQRELDDATEANEGLSREVSTLKNRLRRGGPIS 1935



 Score =  134 bits (336), Expect = 1e-30
 Identities = 171/737 (23%), Positives = 317/737 (43%), Gaps = 99/737 (13%)

Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKS 1647
            QVT Q++E+   D +L   KE+   ++G +                E+  K   + E K+
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGEL---------------EEMERKHQQLLEEKN 890

Query: 1648 LLEELSFQKGELNVQISERKTQLTLIKQE-----------IEKEEENLQVVLRQMSKHKT 1696
            +L E    + EL  +  E + +L   KQE           +E+EEE  Q++  +  K + 
Sbjct: 891  ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950

Query: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVL-----------EEKLELENLQQ 1745
             ++++ + L  E    Q L+L+     ++++K +  +L           E+KL  + + +
Sbjct: 951  HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010

Query: 1746 ISQQQKGEIEWQKQLLE-RDKREI------ERMTAESRA---LQSCVECLSKEKEDLQEK 1795
             S Q   E E  K L + R+K+E+      ER+  E +    L+     L  E  DLQ++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070

Query: 1796 CDIWEKKLAQTKRVLAAAEE--NSKMEQSNLEKLELN-----VRKLQQELDQLNRDKLSL 1848
                + ++ + K  LA  EE     + + + E L  N     VR+LQ ++ +L  D  S 
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130

Query: 1849 HNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV-----LLSEQTR 1903
                +  ++Q ++  E + +L+ EL +  D    A Q  L T + Q+V      L E+T+
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLD--TTAAQQELRTKREQEVAELKKALEEETK 1188

Query: 1904 -LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENK-------LKLVQQEMMFQRLQK 1955
              +  I +   R     +E   + +Q +  +  +E+NK        +L  +  + Q+++ 
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248

Query: 1956 ERESEESKLETSKVTLK---EQQHQLEKELTDQKSKLDQVLSKV-LAAEERVRTLQEEER 2011
            E E +  KL+     L     +  +L  EL ++ SKL   L  V    EE  +   +  +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308

Query: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEK 2071
               SLE  L  T+  L E  +Q +  S  +  L++E +S++      + +    RK  EK
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ----QEEEEEARKNLEK 1364

Query: 2072 QVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA---RRLMKELNQ 2128
            QV +L+  L   + +++ +L   +      +K +   E ++Q   E+A    +L K  N+
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424

Query: 2129 MQYEYTELKKQMANQK----DLERRQMEISDAMRTLKS------EVKDEIRTSLKNLNQF 2178
            +Q E  +L   + +Q+    +LE++Q +    +   KS      E +D      +     
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK 1484

Query: 2179 LPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRG---- 2234
               L   LE  LE  E  E + + L+ ++   M+      K     VH +++  R     
Sbjct: 1485 ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK----NVHELEKSKRALEQQ 1540

Query: 2235 -EALREKLRHREDRLKA 2250
             E +R +L   ED L+A
Sbjct: 1541 VEEMRTQLEELEDELQA 1557



 Score =  127 bits (320), Expect = 1e-28
 Identities = 199/931 (21%), Positives = 394/931 (42%), Gaps = 116/931 (12%)

Query: 248  ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
            + L+ + VT + + +  E   L   ++  + +++K +  + +    ++  EE +    L 
Sbjct: 967  QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026

Query: 308  KSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367
            K   ++ ++     E LK +  T+ EL K K     +   +  +L+ ++A  ++ A+ + 
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKR----KLDGETTDLQDQIA--ELQAQIDE 1080

Query: 368  LNYYPSEYAE-----IDKAPDESPYIGKS-RYKRNMFATESYIIDSAQAVQIKKMEPDEQ 421
            L    ++  E     + +  DE+ +   + +  R + A  + + +  ++ +  + + ++Q
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140

Query: 422  LRNDHMNLRGHTPLDTQLED--------------KEKKISAAQTRLSEL---HD-EIEKA 463
             R+    L     L T+LED              +E++++  +  L E    H+ +I+  
Sbjct: 1141 KRDLSEELEA---LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197

Query: 464  EQQILRATEEF-KQLEEAIQLKKISEAGKDLLY---KQLSGRLQLVNKLRQEALDLELQM 519
             Q+   A EE  +QLE+A + K   E  K  L    K+L+  ++++ +++ E+     ++
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257

Query: 520  EKQKQEIAGKQKEIKDLQIAIDSLDSK-DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL 578
            + Q QE+  K  E   L++ +    SK   +  ++       E++     K    LES+L
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317

Query: 579  DEILSRIAKETEE-------IKDLEEQ---LTEGQIAANEALKKDLEGVISGLQEYLGTI 628
             +    + +ET +       I+ LEE+   L E Q    EA +K+LE  +  LQ  L   
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA-RKNLEKQVLALQSQLADT 1376

Query: 629  K-------GQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
            K       G     +   +KL  + E L QRL E     D+LE        +++EL +L 
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE---KTKNRLQQELDDLT 1433

Query: 682  SALQEQHEVNASLQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQ 737
              L  Q +V ++L++ Q     L A E  + AR    RD    + +E+  K   L +  +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493

Query: 738  SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN 797
             AL+A+ E ERQ  +           K+     +H     L+     L+QQ+++ +  L 
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH----ELEKSKRALEQQVEEMRTQLE 1549

Query: 798  HVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE 857
             + D L   E+   R+            E+N+ +      + L    +Q  E     K  
Sbjct: 1550 ELEDELQATEDAKLRL------------EVNMQAMKAQFERDLQTRDEQNEE-----KKR 1592

Query: 858  RDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIH 917
                QVRE + + E   +Q  LA   ++  +   + LEA++    +  +  I+Q+     
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK--- 1649

Query: 918  YLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELK 977
             LQ  +K  +        +L+EA   ++ I AQ +E EKK K            L+ E+ 
Sbjct: 1650 -LQAQMKDYQR-------ELEEARASRDEIFAQSKESEKKLK-----------SLEAEIL 1690

Query: 978  KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
            +L++ +A+S++        A+ +   L   +      ++  L E  R   + AQ   +L 
Sbjct: 1691 QLQEELASSERARRH----AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE 1746

Query: 1038 RAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGA-NSQVLEIEKLNETMERQRTEI-ARLQ 1095
              ++ +ELL +  R+      L+++       A  S   + +   + +ERQ  E+ A+LQ
Sbjct: 1747 EEQSNMELLNDRFRKT----TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802

Query: 1096 NVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
             +     S  K     +  +I +L  ++  +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833



 Score =  123 bits (309), Expect = 2e-27
 Identities = 209/984 (21%), Positives = 427/984 (43%), Gaps = 132/984 (13%)

Query: 209  QDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFS 268
            Q +S LK LQ   +  L       L H+  + +F        + +P+    RQE   +  
Sbjct: 811  QQLSALKVLQRNCAAYL------KLRHWQWWRVF-------TKVKPLLQVTRQEEELQAK 857

Query: 269  LEEVERLERDLEKKMIETEELKSKQTRFLEE---IKNQDKLNKSLKEEA-------MLQK 318
             EE+ +++    K   E EE++ K  + LEE   +  Q +    L  EA         +K
Sbjct: 858  DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917

Query: 319  QSCEELKSDLNTKNELLKQKTIELTRACQKQ----YELEQELAFYKIDAKFEPLNYYPSE 374
            Q  EE+  DL ++ E  +++   L    +K      +LE++L   +   +   L    +E
Sbjct: 918  QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977

Query: 375  YAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH-- 432
             A+I K  +E   +     K   F  E  +++   A    ++  +E+   +   +R    
Sbjct: 978  -AKIKKMEEEILLLEDQNSK---FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033

Query: 433  ---TPLDTQLEDKEK---KISAAQTRL----SELHDEIEKAEQQILRATEEFKQLEEAIQ 482
               + L+ +L+ +EK   ++  A+ +L    ++L D+I + + QI     +  + EE +Q
Sbjct: 1034 VMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQ 1093

Query: 483  LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
               ++    + L+K  +  L++V +L+ +  +L+   E +K      +K+ +DL   +++
Sbjct: 1094 -GALARGDDETLHK--NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150

Query: 543  L-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE 597
            L     D+ D   +  + +   +++  ++     ++ ++   +I     +    +++L E
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210

Query: 598  QLTEG-QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEV 656
            QL +  +  AN  L+K+ +G+ +  +E    +K    Q + E    R + +  +Q L   
Sbjct: 1211 QLEQAKRFKAN--LEKNKQGLETDNKELACEVK-VLQQVKAESEHKRKKLDAQVQELHAK 1267

Query: 657  EQERDQLEI-VAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLR 715
              E D+L + +A  A  ++ EL  + + L+E  +      +   D ++ E++L+    L 
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK---DAASLESQLQDTQELL 1324

Query: 716  DAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKL 775
              E  Q K  L    R  + E+++LQ + E+E +A KN        ++     S+L    
Sbjct: 1325 QEETRQ-KLNLSSRIRQLEEEKNSLQEQQEEEEEARKN------LEKQVLALQSQLADTK 1377

Query: 776  KHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEVAARVDEL---RRKLKLGTGEMNIH- 830
            K + DD   + + L++ +  L    + L  R EE A   D+L   + +L+    ++ +  
Sbjct: 1378 KKVDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436

Query: 831  SPSDVLGKSLADLQKQFSEILARSK---------WERDEAQVRERKLQ--------EEMA 873
                 +  +L   QK+F ++LA  K          +R EA+ RE++ +        EE  
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496

Query: 874  LQQEKLATGQEEFRQACERALEARMNFDKRQH---------EARIQQMENEIHYLQENLK 924
              +E+     ++ R   E  + ++ +  K  H         E ++++M  ++  L++ L+
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556

Query: 925  SMEEIQGLTDLQLQ--------------EADEEKERIL-AQLRELEKKKKLEDAKSQEQV 969
            + E+ +   ++ +Q              E +EEK+R+L  Q+RELE   +LED + Q  +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE--AELEDERKQRAL 1614

Query: 970  FGLDK-----ELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
                K     +LK L+  +  ++K     +     QL+ L   +    +E  E     + 
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVI----KQLRKLQAQMKDYQRELEEARASRDE 1670

Query: 1025 FSRKAAQAARDLTRAEAEIELLQNLL------RQKGEQFRLEM--EKTGVGTGANSQVLE 1076
               ++ ++ + L   EAEI  LQ  L      R+  EQ R E+  E T   +G ++ + E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730

Query: 1077 IEKLNETMERQRTEIARLQNVLDL 1100
              +L   + +   E+   Q+ ++L
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMEL 1754



 Score =  122 bits (306), Expect = 4e-27
 Identities = 169/767 (22%), Positives = 341/767 (44%), Gaps = 94/767 (12%)

Query: 1635 VTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL---QVVLRQM 1691
            V  K   + +V    EEL  +  EL +++ E++T++    +E+E++ + L   + +L + 
Sbjct: 837  VFTKVKPLLQVTRQEEELQAKDEEL-LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ 895

Query: 1692 SKHKTEL----KNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQIS 1747
             + +TEL    + +   L  +  EL+ +    + RV E E+    +  EK +++   Q  
Sbjct: 896  LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955

Query: 1748 QQQKGEIEWQKQLLERDK----REIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
            ++Q  E E  +Q L+ +K     +I++M  E   L+       KEK+       + E ++
Sbjct: 956  EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK-------LMEDRI 1008

Query: 1804 AQTKRVLAAAEENSK-------MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
            A+    LA  EE +K        ++  +  LE  ++K ++   +L + K  L  + + +Q
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068

Query: 1857 QQLQEKREAVNSLQEELANVQDHLN--LAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
             Q+ E +  ++ L+ +LA  ++ L   LA+ D    T H++  L     LQ  I+E    
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGD--DETLHKNNALKVVRELQAQIAELQED 1126

Query: 1915 FED-------CQKEEETKQQQLQVLQNEIEEN-KLKLVQQEMMFQRLQKERE-----SEE 1961
            FE         +K++    ++L+ L+ E+E+       QQE+  +R Q+  E      EE
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186

Query: 1962 SKLETSKVTLKEQQHQLE-KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTL 2020
            +K   +++    Q+H    +EL++Q   L+Q        E+  + L+ + +      K L
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQ---LEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243

Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRADF----SLLRNQF--------LTERK- 2067
             Q K +   + ++L  +  EL A   E D +R +     S L+N+           E+K 
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303

Query: 2068 -KAEKQVASLKEALKIQRSQLEKNLLEQKQENSCI---QKEMATIELVAQDNHERARRLM 2123
             K  K  ASL+  L+  +  L++   ++   +S I   ++E  +++   ++  E  + L 
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363

Query: 2124 KELNQMQYEYTELKKQMANQ----KDLERRQMEISDAMRTLKSEVK------DEIRTSLK 2173
            K++  +Q +  + KK++ +     + LE  + ++      L   ++      D++  +  
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423

Query: 2174 NLNQFLPELPADLEAILERNENLEGELESLKENLPFTMN-EGPFEEKLNFSQVHIMDEHW 2232
             L Q L +L  DL+   +   NLE + +   + L    +    + E+ + ++    ++  
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483

Query: 2233 R----GEALREKLRHRED------RLKAQLRHCMSKQAEV------LIKGKRQTEGTLHS 2276
            +      AL E L  +E+      +L+A +   MS + +V      L K KR  E  +  
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543

Query: 2277 LRRQVDAL-GELVTSTSADSASSPSLSQLESSLTEDSQL--GQNQEK 2320
            +R Q++ L  EL  +  A      ++  +++    D Q    QN+EK
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590



 Score =  110 bits (276), Expect = 1e-23
 Identities = 231/1064 (21%), Positives = 451/1064 (42%), Gaps = 152/1064 (14%)

Query: 55   QVEIADENNMLLDYQDHKGADSHAGVRYIT-EALIKKLTKQDNLALIKSLNLSLSKDGGK 113
            Q  I D    L    + +GA     +  +T EA IKK+  ++ + L++  N    K+   
Sbjct: 949  QAHIQDLEEQL---DEEEGARQKLQLEKVTAEAKIKKM--EEEILLLEDQNSKFIKE--- 1000

Query: 114  KFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQK 173
                    +K ++  +   S  L  + EK   L K+R  N     IS +E       L+K
Sbjct: 1001 --------KKLMEDRIAECSSQLAEEEEKAKNLAKIR--NKQEVMISDLEE-----RLKK 1045

Query: 174  LNLAGNEIEHIPVWLGKKLKSLR--VLNLKGNKIS-SLQDISKLKPLQDLISL----ILV 226
                  E+E     L  +   L+  +  L+       LQ   K + LQ  ++      L 
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105

Query: 227  ENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
            +N  + +   LQ  I  L+  E  E +  + +++ E  +R   EE+E L+ +LE  +  T
Sbjct: 1106 KNNALKVVRELQAQIAELQ--EDFESEKAS-RNKAEKQKRDLSEELEALKTELEDTLDTT 1162

Query: 287  ---EELKSKQTRFL--------EEIKNQDKLNKSLK-------EEAMLQKQSCEELKSDL 328
               +EL++K+ + +        EE KN +   + ++       EE   Q +  +  K++L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222

Query: 329  NTKNELLKQKTIELTRACQ----KQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
                + L+    EL  AC+    +Q + E E    K+DA+ + L+   SE   +     E
Sbjct: 1223 EKNKQGLETDNKEL--ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280

Query: 385  SPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEP----DEQLRNDHMNLRGHTPLDTQLE 440
                 K+   +N     S +++ A+   IK  +     + QL++    L+  T     L 
Sbjct: 1281 -----KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335

Query: 441  DKEKKISAAQTRLSELHDEIEKA----EQQILRATEEFKQLEEAIQ-----LKKISEAGK 491
             + +++   +  L E  +E E+A    E+Q+L    +    ++ +      ++ + EA K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 492  DLLY--KQLSGRLQ-----------LVNKLRQEALDLELQMEKQKQEIAGKQKEIK--DL 536
             LL   + LS RL+             N+L+QE  DL + ++ Q+Q  +  +K+ K  D 
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 537  QIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLE 596
             +A +   S        +A+   +E++   ++     L   L+E L    +   + K L 
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALS-----LARALEEALEAKEEFERQNKQLR 1510

Query: 597  EQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK---ETLLQ 651
              + +   + ++  K   +LE     L++ +  ++ Q  + ++E +   D K   E  +Q
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 652  RLTEVEQERDQLEIVAMDAENMR---KELAELESALQEQHEVNA----SLQQTQGDLSAY 704
             + + + ERD       + E  R   K++ ELE+ L+++ +  A    S ++ + DL   
Sbjct: 1571 AM-KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629

Query: 705  EAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK 764
            EA++EA        AN+ ++E+ K  R  Q +    Q ELE+ R +      +++ SE+K
Sbjct: 1630 EAQIEA--------ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681

Query: 765  ----EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDG----LVRPEEVAARVDEL 816
                E E  +L  +L   +      +Q+  +  + + +   G    L     + AR+ +L
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741

Query: 817  RRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA-RSKWERDE--AQVRERKLQEEMA 873
              +L+    + N+   +D   K+   +    +E+ A RS  ++ +   Q  ER+ +E  A
Sbjct: 1742 EEELE--EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799

Query: 874  LQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT 933
              QE     + +F+ A   ALEA++   + Q E   ++       ++   K ++EI    
Sbjct: 1800 KLQELEGAVKSKFK-ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858

Query: 934  DLQLQEADEEKERI-LAQLRELEKKKKLEDAKSQ-------------------EQVFGLD 973
            + + + AD+ KE++  A  R  + K++LE+A+ +                   E   GL 
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918

Query: 974  KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAE 1017
            +E+  LK  +     ++ +     + QL  L G  ++++ +  E
Sbjct: 1919 REVSTLKNRLRRGGPISFSSSRSGRRQL-HLEGASLELSDDDTE 1961



 Score =  108 bits (270), Expect = 6e-23
 Identities = 182/744 (24%), Positives = 302/744 (40%), Gaps = 152/744 (20%)

Query: 517  LQMEKQKQEIAGKQKE---IKDLQIAIDS-LDSKDPKHSHMKAQKSGKEQQLDIMNKQY- 571
            LQ+ +Q++E+  K +E   +K+ Q  ++  L+  + KH  +  +K+   +QL    + + 
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904

Query: 572  -------------QQLESRLDEILSRIAKETEE--------------IKDLEEQLTEGQI 604
                         Q+LE  L ++ SR+ +E E               I+DLEEQL E + 
Sbjct: 905  EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964

Query: 605  AAN--EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
            A    +  K   E  I  ++E +  ++ Q ++   E + + D       +L E E++   
Sbjct: 965  ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024

Query: 663  LEIVAMDAENMRKELAEL----ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAE 718
            L  +    E M  +L E     E   QE  +    L     DL    AEL+A+++    +
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084

Query: 719  ANQLKEELE-----------------KVTRLTQLEQSALQAELEKERQALKNA-LGKAQF 760
              + +EEL+                 KV R  Q + + LQ + E E+ +   A   K   
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144

Query: 761  SEEKEQENSELHAKL-----------KHLQDDNNLLKQQLKDFQNHLNHVVDGLVRP--- 806
            SEE E   +EL   L           K  Q+   L K   ++ +NH   + D   R    
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204

Query: 807  -EEVAARVDELRR-KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD--EAQ 862
             EE++ ++++ +R K  L   +  + + +    K LA   K   ++ A S+ +R   +AQ
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDN----KELACEVKVLQQVKAESEHKRKKLDAQ 1260

Query: 863  VRE--------RKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK------------ 902
            V+E         +L+ E+A +  KL    +      E A +  + F K            
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320

Query: 903  --------RQH---EARIQQMENEIHYLQENLKSMEEI-----QGLTDLQLQEADEEK-- 944
                    RQ     +RI+Q+E E + LQE  +  EE      + +  LQ Q AD +K  
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380

Query: 945  ERILAQLRELE--KKKKLEDAKS-----QEQVFGLDKELKKLKKAVATSDKLATAELTIA 997
            +  L  +  LE  KKK L+DA++     +E+    DK L+K K  +       T +L   
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK-LEKTKNRLQQELDDLTVDLDHQ 1439

Query: 998  KDQLKSLHGTVMKINQERAEE----LQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
            +    +L     K +Q  AEE     + AE   R  A+A    T+A +    L+  L  K
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 1054 GE------QFRLEME-----KTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTG 1102
             E      Q R +ME     K  VG   +        L + +E  RT++  L++ L  T 
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT- 1558

Query: 1103 SDNKGGFENVLEEIAELRREVSYQ 1126
                        E A+LR EV+ Q
Sbjct: 1559 ------------EDAKLRLEVNMQ 1570



 Score =  101 bits (252), Expect = 7e-21
 Identities = 128/556 (23%), Positives = 246/556 (44%), Gaps = 86/556 (15%)

Query: 1320 NLENEVSRLEDIMQHLKS---KKREER-WMRASKRQSEKEMEELHHNIDDLLQEKKSLEC 1375
            NLE +  + + ++   KS   +  EER    A  R+ E +   L   +++ L+ K+  E 
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504

Query: 1376 EVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
            + ++L   ++     KD +  NV       E+EKS +  E  V+E+          R++L
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVH------ELEKSKRALEQQVEEM----------RTQL 1548

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
             E        E EL  T E  K  +E    A ++  Q E D +  + + +E    L+K  
Sbjct: 1549 EEL-------EDELQAT-EDAKLRLEVNMQAMKA--QFERDLQTRDEQNEEKKRLLIK-- 1596

Query: 1496 QQLRSLQADAKDLEQH-------KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
             Q+R L+A+ +D  +        K K E  LK++   + A +     + K+  KL  +++
Sbjct: 1597 -QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
              Q+++E A  + D      KESE  L++  AE+ +L       Q+E+A  +R   H ++
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL-------QEELASSERARRHAEQ 1708

Query: 1609 ELHLLQGSMVQA---KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISE 1665
            E   L   +  +   K+ L +  R  E  + +    + E +S +E L+ +  +  +Q+  
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768

Query: 1666 RKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQG-LKLQHDQRVS 1724
               +L   +   +K +   Q + RQ  + K +L+           EL+G +K +    +S
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQ-----------ELEGAVKSKFKATIS 1817

Query: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
             LE  ++  LEE+LE E  ++ +  +         L+ R +++++ +  +       VE 
Sbjct: 1818 ALE-AKIGQLEEQLEQEAKERAAANK---------LVRRTEKKLKEIFMQ-------VED 1860

Query: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
              +  +  +E+ +    ++ Q KR L  AEE +    ++        RKLQ+ELD     
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR-------RKLQRELDDATEA 1913

Query: 1845 KLSLHNDISAMQQQLQ 1860
               L  ++S ++ +L+
Sbjct: 1914 NEGLSREVSTLKNRLR 1929



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 80/452 (17%), Positives = 192/452 (42%), Gaps = 41/452 (9%)

Query: 1320 NLENEVSRLEDIMQHL----KSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC 1375
            ++E+ +S  +D+ +++    KSK+  E+ +   + Q E+  +EL    D  L+ + +++ 
Sbjct: 1512 DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 1376 EVEELHRTVQKRQQQ----KDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKR 1431
               +  R +Q R +Q    K  +   V  L  ELE E+  K     V   + +E  L   
Sbjct: 1572 MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER--KQRALAVASKKKMEIDLKDL 1629

Query: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
             +++  A++   E   +L   + + K+   +  +A+ S  +  + ++E E++ +     +
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689

Query: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
            ++  ++L S +   +  EQ +   +E+  EI    + K +    L  +K +L   + +L+
Sbjct: 1690 LQLQEELASSERARRHAEQER---DELADEITNSASGKSA----LLDEKRRLEARIAQLE 1742

Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH 1611
            +++E  + N +      +++ + +    AEL   +S           L+RQ    K +L 
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802

Query: 1612 LLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLT 1671
             L+G++                          + K+ +  L  + G+L  Q+ +   +  
Sbjct: 1803 ELEGAVKS------------------------KFKATISALEAKIGQLEEQLEQEAKERA 1838

Query: 1672 LIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQV 1731
               + + + E+ L+ +  Q+   +       + ++  N  ++ LK Q ++   E  +   
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898

Query: 1732 AVLEEKLELENLQQISQQQKGEIEWQKQLLER 1763
            +  + + EL++  + ++    E+   K  L R
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 93/474 (19%), Positives = 193/474 (40%), Gaps = 66/474 (13%)

Query: 247  LESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKS---KQTRFLEEIKNQ 303
            LE LE +   T+D +   E        + ERDL+ +  + EE K    KQ R LE     
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607

Query: 304  DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
            ++  ++L   A+  K+  E    DL  + E   +   E+ +  +            K+ A
Sbjct: 1608 ERKQRAL---AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR------------KLQA 1652

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            + +    Y  E  E   + DE            +FA         ++++ + ++  E+L 
Sbjct: 1653 QMKD---YQRELEEARASRDE------------IFAQSKESEKKLKSLEAEILQLQEELA 1697

Query: 424  NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
            +     R     + + ++   +I+ + +  S L DE  + E +I +  EE ++ +  ++L
Sbjct: 1698 SSE---RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754

Query: 484  KKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS- 542
                     L    L+  L       Q++ +   Q+E+Q +E+  K   +++L+ A+ S 
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK---LQELEGAVKSK 1811

Query: 543  ----LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
                + + + K   ++ Q   + ++    NK  ++ E +L EI  ++  E       +EQ
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ 1871

Query: 599  LTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQ 658
            + +    AN  +K+        L+  L   + +AT+A    RKL+ E +   +    + +
Sbjct: 1872 MEK----ANARMKQ--------LKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSR 1919

Query: 659  ERDQLEIVAMDAENMRK----ELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
            E   L+        +R+      +   S  ++ H   ASL+ +  D  +  +++
Sbjct: 1920 EVSTLK------NRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  180 bits (456), Expect = 2e-44
 Identities = 225/1050 (21%), Positives = 485/1050 (46%), Gaps = 126/1050 (12%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            E   ++ +++ +E++   LK+K+     M   + +  +++ E +  +  + +E+K L+ E
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-E 1207

Query: 1377 VEELHRTVQKRQQQKDFI-DGNVESLMTELEIEKS---LKHHEDIVDEI--ECIEKT--- 1427
            +++   T  +R   + +I +     L T+ E++ +   LK H++ +DE+     EKT   
Sbjct: 1208 LQKSFET--ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265

Query: 1428 -----LLKRRSELREADRLLAEAESELSCTKE-----KTKNAVEKFTDAKRSLLQTESDA 1477
                 L K  ++L+E   +L E +  L   KE     +T N +E  T+   +   T    
Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325

Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK-DSDFQCL 1536
             E+ER         ++ +++ +  Q + K L     K+ + LK I + +  K D   + +
Sbjct: 1326 IEMER---------LRLNEKFQESQEEIKSL----TKERDNLKTIKEALEVKHDQLKEHI 1372

Query: 1537 SKKKEKLTEELQKLQKDIEMAERNED-----HHLQVLKESEVLLQAKRAELEKLKSQVTS 1591
             +   K+ E   K ++ + M E++ +       ++  K  +  L     E+  L  ++  
Sbjct: 1373 RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432

Query: 1592 QQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
               EM    + +  +K++L  LQ  +      L+E ++    +  E    ++     L+E
Sbjct: 1433 SHDEM----KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488

Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN-- 1709
                  EL V +SE++T+++ I++++E   + LQ  ++++ + K E  NI  + +++   
Sbjct: 1489 QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE-KEEQFNIKQISEVQEKV 1547

Query: 1710 HELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE 1769
            +EL+  K     + S L+    ++  + LEL N  Q SQ+       + Q++ ++K E++
Sbjct: 1548 NELKQFKEHRKAKDSALQ----SIESKMLELTNRLQESQE-------EIQIMIKEKEEMK 1596

Query: 1770 RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLEL 1829
            R+     ALQ   + L +  +++  K    ++K  Q  ++ A  E   KM +    K + 
Sbjct: 1597 RV---QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF 1653

Query: 1830 NVRKLQQELDQLNRDKLS--LHNDISAMQQQLQEKREAVNSLQEELANVQDHL------- 1880
              +KL  E  +    +L+  LH ++  M+   +E R+ + S++E L   +D L       
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKE-RDDLRSVEETLKVERDQLKENLRET 1712

Query: 1881 ---NLAKQDLL-----HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVL 1932
               +L KQ+ L     H  +HQ+ +     +L+  +SE  N   + QK+ E     L+  
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQETI----DKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768

Query: 1933 QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQV 1992
              +I+E +L++    +      KE++    KL        ++   ++K+L +  +KL   
Sbjct: 1769 DLKIQE-ELRIAHMHL------KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL--- 1818

Query: 1993 LSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK-EADSM 2051
                   +E+++ L+  E    +L+K +++T++++SE EQ   +   + L L K E +++
Sbjct: 1819 -------QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENL 1871

Query: 2052 RADFSLLRNQFLTERKKAEKQVASLK---EALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
                 L  N  L E K   K+  +L+   E LK++R QL+++L E K  +  IQ+E+ T 
Sbjct: 1872 NLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
             ++++++ E   +L +++++   + ++++K +   KD  +++++           VK+++
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLK-ENLPFTMNEGPFEEKLNFSQVHI 2227
              S K +N+ + +L    EA     +NL   ++S++ +N   T       E++      +
Sbjct: 1990 NMSHKKINE-MEQLKKQFEA-----QNL--SMQSVRMDNFQLTKKLHESLEEIRI----V 2037

Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQA---EVLIKGKRQTEGTLH---SLRRQV 2281
              E      ++E L+   D+  A LR  +++     +V  + +  ++G  H   SLR + 
Sbjct: 2038 AKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097

Query: 2282 DALGELVTSTSADSASSPSLSQLESSLTED 2311
              + EL+   S        L++L   L ++
Sbjct: 2098 SRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127



 Score =  165 bits (417), Expect = 6e-40
 Identities = 221/1079 (20%), Positives = 472/1079 (43%), Gaps = 156/1079 (14%)

Query: 1323 NEVSRLEDIMQH----LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE 1378
            NE+ +L++ +++    L++ +RE+  +    +Q+ +E++ L    DDL Q ++SL+ E +
Sbjct: 887  NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946

Query: 1379 EL----HRTVQKRQQQKDFIDGNVESLMTELEIEKSLK-----------HHEDIVDEI-- 1421
            +L    H TV      ++ +   +ESL    E   +LK           H E+   E   
Sbjct: 947  QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006

Query: 1422 ECIEKTL---LKRRSELREADRLLAEA-ESELSCTKEKTKNAVEKFTDAKRSLLQTESDA 1477
            E  +K +    K+  E +    L A+  ++E+   + K  + +++  + ++ L    ++ 
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066

Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
            E+L+   +E     ++  ++LR L  + K       KQ+EI+ +       K+ +   LS
Sbjct: 1067 EQLKTDLKENIEMTIENQEELRLLGDELK-------KQQEIVAQEKNHAIKKEGE---LS 1116

Query: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQ---Q 1594
            +  ++L E  +KL++  +  +  +   L V +E    +Q K  E+E LK+++ +++   +
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE-MQKKINEIENLKNELKNKELTLE 1175

Query: 1595 EMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSF 1654
             M     +L  K  E +    S+ + +  L+E  +  ETE      +IRE+++   +   
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235

Query: 1655 QKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ-MSKHKTELKNILDMLQLENHELQ 1713
            +    ++ + E +  +  +++ +   E+  Q++  Q + K  T+L+  + +L  E   L 
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSV--SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293

Query: 1714 GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQK----QLLERDKREIE 1769
             +K        E+ +TQ  + E +L  E            IE ++    +  +  + EI+
Sbjct: 1294 NVK--------EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK 1345

Query: 1770 RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEEN-SKMEQS-NLEKL 1827
             +T E   L++  E L  + + L+E            +  LA  +E+ SK EQS N+++ 
Sbjct: 1346 SLTKERDNLKTIKEALEVKHDQLKE----------HIRETLAKIQESQSKQEQSLNMKEK 1395

Query: 1828 ELNVRKLQQELDQLN-RDKLSLHNDIS--AMQQQLQEKREAVNSLQEELANVQDHLNLAK 1884
            +    K+  E++Q   +D   L  +I    + ++LQE  + + S+ +E           K
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-----------K 1444

Query: 1885 QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLV 1944
             DL    + Q+VL SE  +L+++I E   +  + ++E +     L+  +  I E ++ L 
Sbjct: 1445 DDL---QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501

Query: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE-KELTDQKSK--------------- 1988
            ++E     +QK+ E+   KL+     + E++ Q   K++++ + K               
Sbjct: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561

Query: 1989 --LDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK 2046
              L  + SK+L    R++  QEE +     ++ + + +  L     QL E + E++A  K
Sbjct: 1562 SALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK 1621

Query: 2047 EADSMRADF----------------SLLRNQFLTER------------------------ 2066
            E+      F                  L+ QF T++                        
Sbjct: 1622 ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM 1681

Query: 2067 ---KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLM 2123
                K    + S++E LK++R QL++NL E    +   Q+E+  + +  +++ E   +L 
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLR 1741

Query: 2124 KELNQMQYEYTELKKQMANQKD-LERRQMEISDAMRTLKSEVK------DEIRTSLKNLN 2176
              +++   E + ++K + +  D L+ + ++I + +R     +K      D++R  +    
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801

Query: 2177 QFLPELPADLEAILERNENLEGELESLK--ENLPFTMNEGPFEEKLNFSQVHIMDEHWRG 2234
              L  +  DLE     N  L+ +++ LK  E+   T+ +   E +   S++  + +  + 
Sbjct: 1802 DKLSNMQKDLE---NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858

Query: 2235 EALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSA 2293
            ++L       E+   AQ  H   ++ + ++K +        +L+ + D L E +  T A
Sbjct: 1859 QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917



 Score =  139 bits (351), Expect = 2e-32
 Identities = 212/1023 (20%), Positives = 437/1023 (42%), Gaps = 184/1023 (17%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASK----RQSEKEMEELHHNIDDLLQEKKSLECE 1376
            ++  V    D+  +      E  W  A+K       E E+  L  + D+L+ + + L  E
Sbjct: 461  IDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520

Query: 1377 VEELHRTVQKRQQQKDFI--------DGNVESLMTELEIEKSLKHHE----DIVDEIECI 1424
             EE+   ++++    +F         D  ++ +     ++  +KH E    D+ +E+   
Sbjct: 521  KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580

Query: 1425 EKTLLKRRSELREADRL-----LAEAESELSCTKEKTKN----------AVEKFTDAKRS 1469
             + L ++  ++++         L   + +LS + E  ++          A     DAKR 
Sbjct: 581  VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640

Query: 1470 LLQTESDAEELERRAQETAVNL--VKADQQLRSLQADAKDLEQHKIKQE--EILKEINKI 1525
                 S+  EL+ + +E A     ++ D QL   Q +AK   Q  +++E      EI K+
Sbjct: 641  SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700

Query: 1526 VAAKDS----DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAE 1581
             +  D     D  C  + + K+T+  ++L K++E  E         L+E  +LL    +E
Sbjct: 701  TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENE--------ALREEVILL----SE 748

Query: 1582 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH 1641
            L+ L S+V         L +++  K EELH++                  +   +E  + 
Sbjct: 749  LKSLPSEVER-------LRKEIQDKSEELHIITSEK--------------DKLFSEVVHK 787

Query: 1642 IREVKSLLEELSFQKGELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKHKTEL 1698
               V+ LLEE+   K +L    S  K+   +    K      E+  ++VL +  +   E+
Sbjct: 788  ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847

Query: 1699 KNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQK 1758
             N+    Q  +  L  LK +   +  EL++    V E   E+E L       K ++E + 
Sbjct: 848  VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL-------KEQLENRD 900

Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
              L+  +RE   +T + +     V+ L++EK+DL++                        
Sbjct: 901  STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ------------------------ 936

Query: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQD 1878
            +++S           LQ E DQL  D   +H+ ++      ++ R A+ SL++     Q+
Sbjct: 937  LQES-----------LQIERDQLKSD---IHDTVNMNIDTQEQLRNALESLKQH----QE 978

Query: 1879 HLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEE 1938
             +N  K  +      +++ + E T   KD  E+  +     K+++ + +  Q L  ++++
Sbjct: 979  TINTLKSKISEEVS-RNLHMEENTGETKD--EFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035

Query: 1939 NKLKLVQQEMMFQRLQKERESEE------SKLETSKVTLKEQ-----QHQLEKELTDQKS 1987
            N++ + QQ  +F  +Q++ E ++      ++ E  K  LKE      ++Q E  L   + 
Sbjct: 1036 NEI-IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094

Query: 1988 KLDQVLSKVLAAEERVRTLQEE---ERWCESL---EKTLSQTKRQLSEREQQLVEKSGEL 2041
            K  Q     + A+E+   +++E    R C+ L   E+ L +  +QL E++QQL+    E+
Sbjct: 1095 KKQQ----EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150

Query: 2042 LALQKEADSMRADFSLLRNQFLT----ERKKAE---------KQVASLKEALKIQRSQLE 2088
              +QK+ + +    + L+N+ LT    E ++ E         ++V S+ +  K+ + +L+
Sbjct: 1151 SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-ELQ 1209

Query: 2089 KNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKE----LNQMQYEYTELKKQMANQK 2144
            K+   ++       +E+    L  ++  + A   +KE    +++++   +E   Q+ N +
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269

Query: 2145 DLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG------ 2198
            DLE+   ++ + +  L  E   E+  ++K +++   E   +LE + E++   +       
Sbjct: 1270 DLEKSHTKLQEEIPVLHEE--QELLPNVKEVSE-TQETMNELELLTEQSTTKDSTTLARI 1326

Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
            E+E L+ N  F  ++   +         +  E    + ++E L  + D+LK  +R  ++K
Sbjct: 1327 EMERLRLNEKFQESQEEIKS--------LTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378

Query: 2259 QAE 2261
              E
Sbjct: 1379 IQE 1381



 Score =  133 bits (335), Expect = 2e-30
 Identities = 220/1062 (20%), Positives = 446/1062 (41%), Gaps = 170/1062 (16%)

Query: 1322 ENEVSRLEDIMQHLKSKKRE--ERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
            + E+ R+++ +Q  + + +E  +  +   K   EKE + L     +  QEK    CE+E 
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM---CEIEH 1648

Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIV---DEIECIEKTLLKRRSELR 1436
            L    + ++   + I+   E++     + ++L+    +    D++  +E+TL   R +L+
Sbjct: 1649 LKEQFETQKLNLENIE--TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLK 1706

Query: 1437 EADRLLA----EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
            E  R       E + EL       K   E   D  R ++  +++     ++  E + + +
Sbjct: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETI-DKLRGIVSEKTNEISNMQKDLEHSNDAL 1765

Query: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
            KA Q L+ +Q + +    H  +Q+E + ++  IV+ K      LS  ++ L     KLQ+
Sbjct: 1766 KA-QDLK-IQEELRIAHMHLKEQQETIDKLRGIVSEKTDK---LSNMQKDLENSNAKLQE 1820

Query: 1553 DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH- 1611
             I+  + NE H L  LK+     Q K +E+E+LK Q+  Q   ++ L+ +  +  ++LH 
Sbjct: 1821 KIQELKANE-HQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879

Query: 1612 -LLQGSMVQAKAD----LQEALRLGETEVTEKCNH-----------IREVKSLLEELSFQ 1655
             L +   V  + D    ++E L+L   ++ E               ++  + L +E    
Sbjct: 1880 NLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKET 1939

Query: 1656 KGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL-----------KNILDM 1704
              +L  +ISE+  Q++ I+++++K ++ LQ  ++++ K + +L           K I +M
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999

Query: 1705 LQLENH-ELQGLKLQ-----------------HDQRVSELEKTQVAVLEEKLELENLQQI 1746
             QL+   E Q L +Q                  + R+   E+ ++  ++E L++E  Q I
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFI 2059

Query: 1747 S--------QQQKGEIEWQKQLLE----------RDK-REIERMTAESRALQSCVECLSK 1787
            +         +Q  +++ +K+LL           R+K   I+ +      +    ECL++
Sbjct: 2060 ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNR 2119

Query: 1788 EKEDLQEKCDIWEKKLA------------QTKRV--LAAAEENSKMEQSNLEKLELNVRK 1833
               DL+++ + ++K+L+            QTK +  L  A +   ME   + K      K
Sbjct: 2120 LSLDLEKEIE-FQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMK------K 2172

Query: 1834 LQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL--LHTT 1891
            L+  L  + + K   H  I+  +    ++ E    L  ++ ++Q   ++  ++L  L   
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232

Query: 1892 KHQDVLLSEQTRLQKDISE-------------WANRFEDCQKEEETKQQQLQV--LQNEI 1936
            ++ D+ + E   + KD SE              +NR E  Q  EE    +  +  L+N I
Sbjct: 2233 QNMDLHIEE---ILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289

Query: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLD---QVL 1993
            ++   ++ Q    F        +E ++ E    T+ ++  Q  K L ++  KL    Q L
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTL 2349

Query: 1994 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
               LA+  +V    ++ +      +    T  ++ E E  L E      A+ KE+     
Sbjct: 2350 KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKES--AMHKES----- 2402

Query: 2054 DFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQ 2113
                              ++  +++ L++    + K   +  + N C++K   TI+++  
Sbjct: 2403 ------------------KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD 2444

Query: 2114 DNHERARRLMKELNQMQYEYTELK-KQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSL 2172
                 A+   +E+  ++ +  ++  ++M N K+ E+   EIS    T++ + K+ IR   
Sbjct: 2445 KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEK---EISATKATVEYQ-KEVIRLLR 2500

Query: 2173 KNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHW 2232
            +NL +   +   D   I E         +    N P T   G    + N   + +  EH 
Sbjct: 2501 ENLRR--SQQAQDTSVISEHT-------DPQPSNKPLTCGGGSGIVQ-NTKALILKSEHI 2550

Query: 2233 RGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
            R E    KL+ + ++L  Q    +S    +  + K   E TL
Sbjct: 2551 RLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTL 2592



 Score =  126 bits (317), Expect = 2e-28
 Identities = 225/1009 (22%), Positives = 452/1009 (44%), Gaps = 142/1009 (14%)

Query: 141  EKLDKLLKLRE-LNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLN 199
            EK  +LL ++E ++    KI++IE ++N    ++L L   E E        +L+  + LN
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETE--------RLELAQKLN 1189

Query: 200  LKGNKISSLQDISK-LKPLQDLISLILVENPVVTLPHYL-QFTIFHLRSLESLEGQPVTT 257
                ++ S+    K LK LQ        E     L  Y+ +     L++ E L+   +  
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSF-----ETERDHLRGYIREIEATGLQTKEELKIAHIHL 1244

Query: 258  QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIK---NQDKLNKSLKEEA 314
            ++ QE     +++E+ R   +   ++I T++L+   T+  EEI     + +L  ++KE +
Sbjct: 1245 KEHQE-----TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299

Query: 315  MLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSE 374
              Q ++  EL        ELL +++         + E+E+     K     E +     E
Sbjct: 1300 ETQ-ETMNEL--------ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350

Query: 375  YAEIDKAPDESPYIGKSRYKRNMFATESYIIDSA--QAVQIKKMEPDEQLRNDHMNLRGH 432
               + K   E+  +   + K ++  T + I +S   Q   +   E D +       +   
Sbjct: 1351 RDNL-KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409

Query: 433  TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLK--KISEAG 490
             P D+ L   E ++     RL E HDE++     + +  ++ ++L+E +Q +  ++ E  
Sbjct: 1410 KPKDSALLRIEIEMLGLSKRLQESHDEMKS----VAKEKDDLQRLQEVLQSESDQLKENI 1465

Query: 491  KDLLYKQLSGRLQL-------------VNKLR-------QEALDLELQMEKQKQEIAGKQ 530
            K+++ K L    +L             +N+LR        E   ++ Q+E    ++  K 
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525

Query: 531  KEI--KDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
            +EI  K+ Q  I  +     K + +K  K  ++ +    +   Q +ES++ E+ +R+ + 
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK----DSALQSIESKMLELTNRLQES 1581

Query: 589  TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
             EEI+ + ++  E +    EAL+ + + +    +E +  +K ++ + + +  K+    ET
Sbjct: 1582 QEEIQIMIKEKEEMK-RVQEALQIERDQLKENTKEIVAKMK-ESQEKEYQFLKMTAVNET 1639

Query: 649  LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
              +++ E+E  ++Q E   ++ EN+  E   L   L E  E   S+ + + DL + E  L
Sbjct: 1640 Q-EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL 1698

Query: 709  EARLNLRDAEANQLKEEL-EKVTR--LTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
            +        E +QLKE L E +TR    Q E   +   L++ ++ +    G      EK 
Sbjct: 1699 K-------VERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRG---IVSEKT 1748

Query: 766  QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTG 825
             E S +   L+H    N+ LK Q    Q  L      L   +E    +D+LR  +   T 
Sbjct: 1749 NEISNMQKDLEH---SNDALKAQDLKIQEELRIAHMHLKEQQET---IDKLRGIVSEKTD 1802

Query: 826  EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE 885
            +++  +    L  S A LQ++  E+ A      +E Q+    L++++   Q+K++  ++ 
Sbjct: 1803 KLS--NMQKDLENSNAKLQEKIQELKA------NEHQL--ITLKKDVNETQKKVSEMEQL 1852

Query: 886  FRQACERALE------ARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQE 939
             +Q  +++L         +N  ++ HE  +++M++ +   ++NL+ +EE   L   QL+E
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHE-NLEEMKS-VMKERDNLRRVEETLKLERDQLKE 1910

Query: 940  ADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKL--ATAELTIA 997
            + +E      + R+LE +++L+ A+       L KE K+      T DKL    +E TI 
Sbjct: 1911 SLQE-----TKARDLEIQQELKTARM------LSKEHKE------TVDKLREKISEKTI- 1952

Query: 998  KDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF 1057
              Q+  +   + K   E  +++QE ++   +  +   D+  +  +I  ++ L +Q   Q 
Sbjct: 1953 --QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ- 2009

Query: 1058 RLEMEKTGVGTGANSQVLEIEKLNETME------RQRTEIARLQNVLDL 1100
             L M+   +    N Q+   +KL+E++E      ++R E+ R++  L +
Sbjct: 2010 NLSMQSVRMD---NFQL--TKKLHESLEEIRIVAKERDELRRIKESLKM 2053



 Score =  118 bits (296), Expect = 6e-26
 Identities = 201/965 (20%), Positives = 408/965 (42%), Gaps = 126/965 (13%)

Query: 244  LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETE---------ELKSKQT 294
            L +L  +E  P T    QE  E     E+  L  D +  +++ E         ELK K+ 
Sbjct: 476  LDTLSEIEWNPATKLLNQENIE----SELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK 531

Query: 295  RFLEEIKNQDKLNKSLKEEAMLQKQSC------------EELKSDLNTKNELLKQKTIEL 342
              L+E +  ++  K  +E  ++ + S             ++L+++L++K ELL++K  ++
Sbjct: 532  NDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQI 591

Query: 343  TRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATES 402
             +   ++Y   Q+L   K+D        Y  E  E  K           + K+ +F  E+
Sbjct: 592  KKL--QEYIDSQKLENIKMDLS------YSLESIEDPK-----------QMKQTLFDAET 632

Query: 403  YIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEK 462
              +D+ +     + E  E           +  ++  ++  + ++ A +    +L  E++ 
Sbjct: 633  VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692

Query: 463  AEQQILRATEEFKQLEEAIQLKKISEAGKDL-LYKQLSGRLQLVNKLRQEALDLELQMEK 521
            A  +I + T           L  +   GK   L K+L+  ++    LR+E + L  +++ 
Sbjct: 693  AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS-ELKS 751

Query: 522  QKQEIAGKQKEIKDLQIAIDSLDS-KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDE 580
               E+   +KEI+D    +  + S KD   S +  ++S  +  L+ + K    L +    
Sbjct: 752  LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811

Query: 581  ILSRIAKETEEIKDLE---EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
              S   +E +  K L    EQ  +  +  NE + +++  +    Q++  ++    T+   
Sbjct: 812  YKST-DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870

Query: 638  ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQT 697
            + ++L+++   + +RL E+EQ ++QLE      + + +E   +   LQ+  E   +L Q 
Sbjct: 871  KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930

Query: 698  QGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELE--KERQALKNAL 755
            + DL   +  L+        E +QLK ++     +    Q  L+  LE  K+ Q   N L
Sbjct: 931  KDDLKQLQESLQ-------IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983

Query: 756  GKAQFSEEKE-----QENS------------------ELHAK----LKHLQDDNNLLKQQ 788
             K++ SEE       +EN+                  +L AK    L     DN +++QQ
Sbjct: 984  -KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1042

Query: 789  LKDF-----QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
             K F     +N L  ++      E V A  ++L+  LK    EM I +  ++  + L D 
Sbjct: 1043 RKIFSLIQEKNELQQML------ESVIAEKEQLKTDLKENI-EMTIENQEEL--RLLGDE 1093

Query: 844  QKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKR 903
             K+  EI+A+ K    + +    +  + +A  +EKL    ++ ++  ++ L  +    + 
Sbjct: 1094 LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM 1153

Query: 904  QHEA-RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQ---LRELEKKKK 959
            Q +   I+ ++NE+   +  L+ ME  +     +L E  EE + I  +   L+EL+K  +
Sbjct: 1154 QKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFE 1213

Query: 960  LEDAKSQEQVFGLD-------KELK----KLKKAVATSDKL--ATAELTIAKDQLKSLHG 1006
             E    +  +  ++       +ELK     LK+   T D+L  + +E T      + L  
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK 1273

Query: 1007 TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV 1066
            +  K+ +E     +E E        +    T  E E+   Q+  +      R+EME+  +
Sbjct: 1274 SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333

Query: 1067 GTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
                N +  E ++  +++ ++R  +  ++  L++     K   E++ E +A+++   S Q
Sbjct: 1334 ----NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK---EHIRETLAKIQESQSKQ 1386

Query: 1127 NDYIS 1131
               ++
Sbjct: 1387 EQSLN 1391



 Score =  108 bits (270), Expect = 6e-23
 Identities = 177/834 (21%), Positives = 369/834 (44%), Gaps = 117/834 (14%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEK---EMEELHHNIDDLLQEKKSLECE 1376
            +LEN  ++L++ +Q LK+ + +   ++    +++K   EME+L   I D       LE E
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE 1869

Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDE-IECIEKTLLKRRSEL 1435
               L + + +  ++   +    ++L     +E++LK   D + E ++  +   L+ + EL
Sbjct: 1870 NLNLAQKLHENLEEMKSVMKERDNLR---RVEETLKLERDQLKESLQETKARDLEIQQEL 1926

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
            + A  L  E +  +   +EK      + +D ++ L   +   +EL+++ QE    L K +
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTIQISDIQKDL---DKSKDELQKKIQE----LQKKE 1979

Query: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
             QL  ++ D  ++   KI + E LK   K   A++   Q +     +LT++L +  ++I 
Sbjct: 1980 LQLLRVKEDV-NMSHKKINEMEQLK---KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035

Query: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
            +  +  D  L+ +KES          L+  + Q  +  +EM   DRQ    K E  LL  
Sbjct: 2036 IVAKERDE-LRRIKES----------LKMERDQFIATLREMIARDRQNHQVKPEKRLLS- 2083

Query: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKS------------------LLEELSFQKG 1657
                 +  L E+LR       EKC+ I+E+                    L +E+ FQK 
Sbjct: 2084 ---DGQQHLTESLR-------EKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK- 2132

Query: 1658 ELNVQISERKTQLTLIKQEIEKE--------------EENLQVVLRQMSKHKTELKNILD 1703
            EL++++    +   L  + IEK                + L+ VL  ++K K E    ++
Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESIN 2192

Query: 1704 MLQL------ENHELQGLKLQHDQRVSELEKTQVAVLE--EKLEL---ENLQQISQQQKG 1752
              ++      E  +   +K+QH Q+  ++   ++  L+  + ++L   E L+  S+ +  
Sbjct: 2193 KFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFP 2252

Query: 1753 EIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD-IWEKKLAQTKRVLA 1811
             I+ + Q +  +++E+ +   E    +  +E   K K  +Q++ D I +       R++A
Sbjct: 2253 SIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE---KLKNGIQKENDRICQVNNFFNNRIIA 2309

Query: 1812 AAEENSKMEQSNL---EKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ---QLQEKRE- 1864
               E+++ E+ +    ++ E +++ L+++ ++L ++  +L   +++  Q     Q+ +  
Sbjct: 2310 IMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNP 2369

Query: 1865 -----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI-SEWANRFEDC 1918
                 A     E++  +++ L+ AK+  +H  + + + + ++  +  DI ++   +  + 
Sbjct: 2370 HVTSRATQLTTEKIRELENSLHEAKESAMHK-ESKIIKMQKELEVTNDIIAKLQAKVHES 2428

Query: 1919 QKEEETKQQQLQVLQN-----------EIEENKLKLVQQEMMFQRLQKERESEESKLETS 1967
             K  E  ++ +QVLQ+           EIE+ K+KLV+ ++   +  KE E E   +  +
Sbjct: 2429 NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKE---ISAT 2485

Query: 1968 KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
            K T+ E Q ++ + L +   +  Q     + +E        +   C      +  TK  +
Sbjct: 2486 KATV-EYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI 2544

Query: 2028 SEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK 2081
             + E   +EK    L  Q E    + +  L  NQ L+   K  K+    +EA K
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHK 2598



 Score =  107 bits (267), Expect = 1e-22
 Identities = 214/1061 (20%), Positives = 435/1061 (40%), Gaps = 162/1061 (15%)

Query: 57   EIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFK 116
            E+ ++ N L  +++H+ A   A      +++  K+ +  N        + +     ++ K
Sbjct: 1542 EVQEKVNELKQFKEHRKAKDSA-----LQSIESKMLELTNRLQESQEEIQIMIKEKEEMK 1596

Query: 117  YIENLEKCVKLEVLNLSYNLIGKI----EKLDKLLKLRELNLSYNKISKIEGIENMCNLQ 172
             ++   +  + ++   +  ++ K+    EK  + LK+  +N +  K+ +IE ++     Q
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656

Query: 173  KLNLAGNEIEHIPVW--LGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPV 230
            KLNL   E E+I +   L + L+ +R +  + + + S+++  K++  +D +   L E   
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE--RDQLKENLRETIT 1714

Query: 231  VTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELK 290
              L    +  I H+   E  E     T D+          E+  +++DLE      + LK
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQE-----TIDKLRGIVSEKTNEISNMQKDLEHS---NDALK 1766

Query: 291  SKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQY 350
            ++  +  EE++     +  LKE    Q+++ ++L+  ++ K + L     +L  +  K  
Sbjct: 1767 AQDLKIQEELRIA---HMHLKE----QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819

Query: 351  ELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQA 410
            E  QEL      A    L     +  E  K   E   + K    +++  ++  I +   A
Sbjct: 1820 EKIQELK-----ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874

Query: 411  VQI-KKMEPDEQLRNDHMNLRG-HTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
             ++ + +E  + +  +  NLR     L  + +  ++ +   + R  E+  E++ A     
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSK 1934

Query: 469  RATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAG 528
               E   +L E I  K I  +    + K L      + K  QE    ELQ+ + K+++  
Sbjct: 1935 EHKETVDKLREKISEKTIQISD---IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991

Query: 529  KQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRI--- 585
              K+I +++               +K Q   +   +  +     QL  +L E L  I   
Sbjct: 1992 SHKKINEME--------------QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037

Query: 586  AKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE 645
            AKE +E++ ++E           +LK + +  I+ L+E +   + Q  Q + E R L D 
Sbjct: 2038 AKERDELRRIKE-----------SLKMERDQFIATLREMIARDR-QNHQVKPEKRLLSDG 2085

Query: 646  KE--------------TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVN 691
            ++               LL+R +E++   + L  +++D E   KE+ E +  L  + + N
Sbjct: 2086 QQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE---KEI-EFQKELSMRVKAN 2141

Query: 692  ASLQ--QTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
             SL   QT+     + A     +        +LK  L  VT++             KE Q
Sbjct: 2142 LSLPYLQTKHIEKLFTANQRCSMEFHRI-MKKLKYVLSYVTKI-------------KEEQ 2187

Query: 750  ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDF---QN---HLNHVVDGL 803
                   +  F +E E++  EL  K++HLQ D ++  ++L+D    QN   H+  ++   
Sbjct: 2188 HESINKFEMDFIDEVEKQK-ELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDF 2246

Query: 804  VRPE---------EVAARVDELRR-------------KLKLGTGEMN--IHSPSDVLGKS 839
               E         +V +   E+ +             KLK G  + N  I   ++     
Sbjct: 2247 SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNR 2306

Query: 840  LADLQKQFSEILARS-----KWERDEAQVRER--KLQEEMALQQEKLATGQEEFRQACER 892
            +  +  + +E   RS     +WE+D   ++E+  KL +     +  LA+G +      + 
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366

Query: 893  ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLR 952
                  +   +    +I+++EN +H  +E+                 A  ++ +I+   +
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKES-----------------AMHKESKIIKMQK 2409

Query: 953  ELEKKKKLEDAKSQEQVFGLDKELKKLKKAV-ATSDKLATAELTIAKDQLKSLHGTVMKI 1011
            ELE    +  AK Q +V   +K L+K K+ +    DK+A      AK   + +    MK+
Sbjct: 2410 ELEVTNDI-IAKLQAKVHESNKCLEKTKETIQVLQDKVALG----AKPYKEEIEDLKMKL 2464

Query: 1012 NQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQ 1052
             +   E+++ A+ F ++ +     +   +  I LL+  LR+
Sbjct: 2465 VKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 140/689 (20%), Positives = 282/689 (40%), Gaps = 134/689 (19%)

Query: 1315 VPEHHNLENE-VSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNI-------DDL 1366
            V E  N+ ++ ++ +E + +  +++    + +R    Q  K++ E    I       D+L
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044

Query: 1367 LQEKKSLECEVEELHRTV-----------QKRQQQKDFIDGN---VESLMTELE-IEKSL 1411
             + K+SL+ E ++   T+           Q + +++   DG     ESL  +   I++ L
Sbjct: 2045 RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104

Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
            K + ++ D  EC+ +  L    E+     L    ++ LS    +TK+  + FT  +R  +
Sbjct: 2105 KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM 2164

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
            +                  ++K  + + S     K+ EQH        + INK     + 
Sbjct: 2165 EFH---------------RIMKKLKYVLSYVTKIKE-EQH--------ESINKF----EM 2196

Query: 1532 DFQCLSKKKEKLTEELQKLQKDIEMAER---------NEDHHLQVLKESEVLLQAKRAEL 1582
            DF    +K+++L  ++Q LQ+D ++  R         N D H++     E+L     +E 
Sbjct: 2197 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIE-----EILKDFSESEF 2251

Query: 1583 EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHI 1642
              +K++            + L ++KE    L+   +  + D+ E L+ G   + ++ + I
Sbjct: 2252 PSIKTE----------FQQVLSNRKEMTQFLE-EWLNTRFDI-EKLKNG---IQKENDRI 2296

Query: 1643 REVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL 1702
             +V +            + +  ER      I +E E++ ++L+    ++ K+   LK  L
Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFEERS---ATISKEWEQDLKSLKEKNEKLFKNYQTLKTSL 2353

Query: 1703 DMLQLENHELQGLKLQH-DQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
                  N   Q  K  H   R ++L   ++  LE  L  E  +    ++   I+ QK+ L
Sbjct: 2354 ASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH-EAKESAMHKESKIIKMQKE-L 2411

Query: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
            E     I ++ A+   +    +CL K KE +Q         + Q K  L A     ++E 
Sbjct: 2412 EVTNDIIAKLQAK---VHESNKCLEKTKETIQ---------VLQDKVALGAKPYKEEIED 2459

Query: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
              ++ +++++ K+        ++      +ISA +  ++ ++E +  L+E L   Q    
Sbjct: 2460 LKMKLVKIDLEKM--------KNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQ--- 2508

Query: 1882 LAKQDLLHTTKHQD-----------------------VLLSEQTRLQKDISEWANRFEDC 1918
               QD    ++H D                       +L SE  RL+K+IS+   + E  
Sbjct: 2509 --AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL 2566

Query: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
             K++       Q L NE++  K + +++E
Sbjct: 2567 IKQKNELLSNNQHLSNEVKTWKERTLKRE 2595



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 159/773 (20%), Positives = 313/773 (40%), Gaps = 135/773 (17%)

Query: 474  FKQLEEAIQLKKISEAGKDLLY-KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKE 532
            F +   A+Q    ++  K+  Y  ++S    L+ + R+E +DL+ Q+E+   E   +  E
Sbjct: 313  FDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAME 372

Query: 533  IKDLQIAIDSLD-------SKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRI 585
               L   ++  D        K    + M    S    Q ++  K+ +++   L +I    
Sbjct: 373  KDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMK 432

Query: 586  AKETEEIKDLEEQLTEGQIAANEALKKDL-EGVISGLQEYLGTIKGQATQAQNECRKLRD 644
                 +  ++   +T      +  L +++ E V S    +  T+   +    N   KL +
Sbjct: 433  NSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLN 492

Query: 645  EKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH---EVNASLQQTQGDL 701
            + E +   L  +  + D L    +D E +R E  E+E  L+E++   E  A  ++T+ D 
Sbjct: 493  Q-ENIESELNSLRADYDNL---VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548

Query: 702  SA----------------------YEAELEARLNLRDAEANQLKE--------------- 724
                                     E EL +++ L   + +Q+K+               
Sbjct: 549  EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608

Query: 725  ----ELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780
                 LE +    Q++Q+   AE        ++A  +++  E KE +  EL    K +++
Sbjct: 609  DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKE-KMKELATTYKQMEN 667

Query: 781  DNNLLKQQL-----------KDFQNHLNHV------VDGLVRPE-----EVAARVDELRR 818
            D  L + QL           K+ Q+  N +      +DG V  +     E+  ++ +L++
Sbjct: 668  DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727

Query: 819  KLKLGTGE--------------MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
            +L     E               ++ S  + L K + D  ++   I +       E   +
Sbjct: 728  ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787

Query: 865  ERKLQ---EEMALQQEKLATGQEEFR---QACERALEARMNFDKRQHEA--RIQQMENEI 916
            E ++Q   EE+   ++ LAT Q  ++   Q  +      M+F+++        ++M  EI
Sbjct: 788  ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847

Query: 917  HYLQENLKSMEEIQGLTDLQL----QEADEEKERILAQLRELEK-KKKLEDAKSQEQVF- 970
              L +  +  +   G    +L    QE  E+   +  +L E+E+ K++LE+  S  Q   
Sbjct: 848  VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907

Query: 971  --------GLDKELKKLKKAVATSDKLATAE--LTIAKDQLKS-LHGTVMKINQERAEEL 1019
                     L + L+++K      D L   +  L I +DQLKS +H TV  +N +  E+L
Sbjct: 908  REKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV-NMNIDTQEQL 966

Query: 1020 QEAERFSRKAAQAARDLTRAEAEIELLQNL-LRQKGEQFRLEMEKTGVG-------TGAN 1071
            + A   S K  Q   +  +++   E+ +NL + +   + + E ++  VG          N
Sbjct: 967  RNALE-SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025

Query: 1072 SQVLEIE-KLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREV 1123
            +Q L  + K NE +E+QR   + +Q   +L     +   E+V+ E  +L+ ++
Sbjct: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNEL-----QQMLESVIAEKEQLKTDL 1073



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 66/315 (20%), Positives = 147/315 (46%), Gaps = 29/315 (9%)

Query: 1914 RFEDCQKEEETKQQQLQVLQNEIEENKL-KLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
            R E    +++ ++  L+     +E+++L +L++++ + Q++Q E+    +++  +  +L 
Sbjct: 349  RKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLT 408

Query: 1973 EQQH---QLEKELTDQKSKLDQVLSKVLAAEERVRT-------------LQEEERWCESL 2016
             QQ    + ++ +T    K++++ +   A +  + T             L+E +    S 
Sbjct: 409  LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSE 468

Query: 2017 EKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLL---RNQFLTERKKAE--- 2070
                S T   LSE E     K      ++ E +S+RAD+  L     Q  TE+++ E   
Sbjct: 469  SDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL 528

Query: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 2130
            K+   L E   ++R   +   ++   E S ++  +   E+  QD        ++ L + +
Sbjct: 529  KEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588

Query: 2131 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAIL 2190
             +  +L++ + +QK LE  +M++S ++ ++  E   +++ +L +       L A  E+  
Sbjct: 589  DQIKKLQEYIDSQK-LENIKMDLSYSLESI--EDPKQMKQTLFDAETV--ALDAKRESAF 643

Query: 2191 ERNENLEGELESLKE 2205
             R+ENLE + E +KE
Sbjct: 644  LRSENLELK-EKMKE 657



 Score = 36.6 bits (83), Expect = 0.30
 Identities = 99/569 (17%), Positives = 221/569 (38%), Gaps = 79/569 (13%)

Query: 57   EIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFK 116
            ++  E  +L D Q H           I E L +     D+   +  L+L L K+     +
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE----IE 2129

Query: 117  YIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNL 176
            + + L   VK   L+L Y     IEKL      +  ++ +++I K               
Sbjct: 2130 FQKELSMRVKAN-LSLPYLQTKHIEKL--FTANQRCSMEFHRIMK--------------- 2171

Query: 177  AGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHY 236
               +++++  ++  K+K  +  ++   ++  + ++ K K L            ++ + H 
Sbjct: 2172 ---KLKYVLSYV-TKIKEEQHESINKFEMDFIDEVEKQKEL------------LIKIQHL 2215

Query: 237  LQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRF 296
             Q      R L  L+         +E  + FS  E   ++ + ++ +   +E+    T+F
Sbjct: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEM----TQF 2271

Query: 297  LEEIKNQ----DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYEL 352
            LEE  N     +KL   +++E     + C+      N    ++ + T    R+     E 
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKE---NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEW 2328

Query: 353  EQELAFYK-----IDAKFEPLNYYPSEYAEIDKAPDES--PYIGKSRYK---RNMFATES 402
            EQ+L   K     +   ++ L    +  A+++    ++  P++     +     +   E+
Sbjct: 2329 EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELEN 2388

Query: 403  YIIDSAQAVQIK-----KMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELH 457
             + ++ ++   K     KM+ + ++ ND +       L  ++ +  K +   +  +  L 
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDII-----AKLQAKVHESNKCLEKTKETIQVLQ 2443

Query: 458  DEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLEL 517
            D++    +      E+ K     I L+K+  A +    K++S     V   ++    L  
Sbjct: 2444 DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE--FEKEISATKATVEYQKEVIRLLRE 2501

Query: 518  QMEKQKQ--------EIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK 569
             + + +Q        E    Q   K L     S   ++ K   +K++    E+++  + +
Sbjct: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQ 2561

Query: 570  QYQQLESRLDEILSRIAKETEEIKDLEEQ 598
            Q +QL  + +E+LS     + E+K  +E+
Sbjct: 2562 QNEQLIKQKNELLSNNQHLSNEVKTWKER 2590


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  177 bits (448), Expect = 1e-43
 Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)

Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
            L++ +  +  +   DE++  ++   K  +EL+E ++  ++   E +  +E+ +   E + 
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
            +A+   ++  +  +ELE    E    L + + + + LQA+ K + Q  +  EE L+E   
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
                  + K+ A              D     LSK+++ L E +  L  ++   E     
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
                ++ H  ++ E EV L   +  R ELEKLK            Q+   Q ++A L  Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
            L  K+EEL      +    A    AL+    ++ E   HI +++  L+     + +   Q
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
              +   +L  +K E+E   ++    Q +  +  +  T LK  LD  +  +HE  +Q ++ 
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1199

Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
            +H Q V EL +        K  L+  +Q  +++  ++  + ++L + K+E+E    ++ A
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259

Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
            + + LQS      + + +L +K    + ++     +L  AE  +     ++  L   ++ 
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
             Q+ L +  R KL+       L  + +++Q QL E+ EA  +L+  ++ +   L+ +K+ 
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
            L       + L   + R QK+I     ++E+     +  ++    LQ E+++  + L  Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
              +   L+K++   +  L   K    +   + ++   + + K  + LS   A EE +   
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
            +E ER                         LEK+    + Q+ E + QL E   EL A +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559

Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
                 +  +   L+ QF  + +  ++Q    +  L+ Q  + E  L +++++ +      
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619

Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
              ++ ++  +EL A    +     +K+L ++Q +  + ++++ +                
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679

Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
                  + DL + Q +++ A R        K E+ +E+ +SL   N    E   L A + 
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
             + E  E  +G +E++ + +     +    E+L+           + E+ R++L  +   
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
            L+++L      + E  +K K   + T+ +L  ++  L E V   + +  A++ SL Q + 
Sbjct: 1797 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 2307 SLTE 2310
             L E
Sbjct: 1850 KLKE 1853



 Score =  160 bits (405), Expect = 1e-38
 Identities = 201/1045 (19%), Positives = 453/1045 (43%), Gaps = 126/1045 (12%)

Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
            D+ + L+ ++   + ++  K  +E ++++L   I   DD    L +E+K LE  + +L  
Sbjct: 954  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
             + + +++   +       ES+++ELE+   LK  E    E+E +++ L           
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
               ++++ E    LA+ E EL     +  + + +  +A + + + E    +L+       
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
                KA++Q R L    ++LE  K + E+ L       ++ A ++ +   L K  ++ T 
Sbjct: 1132 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188

Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
                ++Q++++    A       L+  K ++  L   +  LEK  + +  + + +    +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248

Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
            ++ HKK++L   Q   +Q+K    E  R    +   K  N +  V  +L E   +  +L 
Sbjct: 1249 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
              ++   +QL           ++ Q +L++ ++ K  +   L  L+ E + LQ      D
Sbjct: 1308 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1350

Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            Q   E+E  Q   LE  +   N+Q    ++K         L+     +E +    +  Q 
Sbjct: 1351 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1399

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             +E L+++ E+     D    KL +TK  L    ++  ++  N  +L  N+ K Q++ DQ
Sbjct: 1400 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
            L  ++ ++ +  +  + + + +     +    LA   +    AK++L  T K     + +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
                + D+ +  +  E  ++  ET+ +    QL+ L++E+   E+ KL+L V  + +  +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
             +++ ++ + + E  +  L+ Q H+ E EL D+          K KL+  L  + L A+ 
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
             ++  +E  +    L+  +   +R+L +      E        +K+A S+ AD   L+  
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695

Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
                        L + + AE+  +SL  + AL+ ++ +LE  + + ++E   +++E   +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1752

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
            E ++    +  ++  +  N++  E +  +K  + ++ LER+  E+   +  ++  VK + 
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
            ++++  L   + +L   +E   +     +   +SLK+           ++KL    + + 
Sbjct: 1813 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1859

Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
            DE    E  +E+      R+K      + +Q E   +  ++       L+R++D      
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1908

Query: 2289 TSTSADSASSPSLSQLESSLTEDSQ 2313
             +T ++ A    ++ L+S L   ++
Sbjct: 1909 EATESNEAMGREVNALKSKLRRGNE 1933



 Score =  135 bits (340), Expect = 5e-31
 Identities = 193/934 (20%), Positives = 393/934 (42%), Gaps = 137/934 (14%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            S + ++   LK +++  + +   KR+ E +  + H  I DL       + ++ EL   + 
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-------QAQIAELKMQLA 1086

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
            K++++       ++  + +     +LK   ++   I  +++ L   R+   +A++   + 
Sbjct: 1087 KKEEELQAALARLDDEIAQKN--NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 1446 ESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA 1505
              EL   K          T+ + +L  T +  E   +R QE  V     D++ RS +A  
Sbjct: 1145 GEELEALK----------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 1506 KDLEQ-HKIKQEEILKEINKIVAAK---DSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 1561
            +++ Q H    EE+ +++ +   AK   D + Q L K+   L  EL+ L +    A++  
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----AKQEV 1250

Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQ----QQEMAVLDRQLGHKKEELHLLQGSM 1617
            +H  + L+     LQ+K ++ E+ ++++  +    Q E+  +   L   + +   L   +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310

Query: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
                + LQ+   L + E  +K N    V + L +L  ++  L  Q+ E        KQ +
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEA----KQNL 1362

Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENH----ELQGLKLQHDQRVS---ELEKTQ 1730
            E+    L + L    K   +  + ++ L+        E++ L  Q++++ +   +LEKT+
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 1731 VAVLEEK----LELENLQQ-ISQQQKGEIEWQKQLLE-----------RDKREIERMTAE 1774
              + +E     ++L+N +Q +S  +K + ++ + L E           RD+ E E    E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 1775 S------RALQSCVEC----------LSKEKEDL-QEKCDIWEK--KLAQTKRVLAAAEE 1815
            +      RAL+  +E           L  E EDL   K D+ +   +L ++KR L    E
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 1816 NSKMEQSNLE-----------KLELNVRKLQ-------QELDQLNRDKL-SLHNDISAMQ 1856
              K +   LE           +LE+N++ L+       Q  D+ N +K   L   +   +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
             +L+++R+           ++  L   +       K ++  + +  +LQ  + ++    E
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 1917 DCQ----------KEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE----- 1961
            D +          KE E K + L+    +++E+ L   ++      L+KE  +EE     
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQED-LAAAERARKQADLEKEELAEELASSL 1721

Query: 1962 ---SKLETSKVTLKEQQHQLEKELTDQKSKL----DQVLSKVLAAEERVRTLQEEERWCE 2014
               + L+  K  L+ +  QLE+EL +++  +    D+V      AE+    L  E    +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781

Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA-DSMRADFSLLRNQFLTERKKAEKQV 2073
              E    Q +RQ  E   +L E  G + +  K    ++ A  + L  Q   E ++ +   
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841

Query: 2074 ASLKEALKIQRSQL-----EKNLLEQKQENS--------CIQKEMATIELVAQDNHERAR 2120
             SLK+  K  +  L     E+ + EQ +E +         +++++   E  +Q  +   R
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901

Query: 2121 RLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
            +L +EL++       + +++   K   RR  E S
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935



 Score =  134 bits (336), Expect = 1e-30
 Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)

Query: 285  ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
            + EE+++K+    +  + Q K    LKE      Q  EE   L+  L  + EL  +    
Sbjct: 850  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 342  LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
              R   K+ ELE+ L  ++++A+ E                                   
Sbjct: 910  RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 935

Query: 402  SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
                D  Q +Q ++ +  +Q+ +          L+ QLE++E   +K+      A+ ++ 
Sbjct: 936  ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 455  ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
            +L DEI   + Q  + ++E K LEE I     + A ++   K L+   +L NK      +
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1038

Query: 515  LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
            LE++++K+++     ++E++ L+  ++  D+ D                    ++Q   L
Sbjct: 1039 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1074

Query: 575  ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
            ++++ E+  ++AK+ EE++    +L +     N ALKK  +LEG IS LQE L + +   
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 633  TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
             +A+ + R L +E E L    TE+E   D             +E+  L+ AL E      
Sbjct: 1135 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1185

Query: 693  SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
                   +  ++EA+++           +L E+LE+  R         +A L+K +Q L 
Sbjct: 1186 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1229

Query: 753  NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
                        E+EN++L  +L+        ++     L+ Q+++ Q+  +   DG   
Sbjct: 1230 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1274

Query: 806  PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
              E+  +V +L+ +++  TG +N     +  L K +A L  Q     E+L     ++   
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334

Query: 862  QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
              + R+L+EE    Q++L   + E +Q  ER + + +N      + ++Q   + +  L+E
Sbjct: 1335 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 922  NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
              K  + EI+ LT        ++ E   A   +LEK K     +  + V  LD +   + 
Sbjct: 1393 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 978  KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
             L+K     D+L   E  I+            K   ER     EA     KA   AR L 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1493

Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
             A EA+ EL +     K E   L   K  VG   +        L   ME  +T++  L++
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
             L  T              KG FE  L    E+  E RR++  Q ++Y + + D  K+R
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612



 Score =  131 bits (329), Expect = 9e-30
 Identities = 218/976 (22%), Positives = 424/976 (43%), Gaps = 126/976 (12%)

Query: 247  LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
            ++ LE + +   D+      ER  LEE +  L  +L   E+K     +LK+K    + E+
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039

Query: 301  KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
            + + K  +  ++E    K+  E   SD + +   L+ +  EL     K+ E E + A  +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1098

Query: 361  IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
            +D +    N    +  E++    D    +   R  RN    E    D  + ++  K E +
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1156

Query: 420  EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
            + L +        T    +L  K E++++  +  L E    H+ ++++  Q+  +A EE 
Sbjct: 1157 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 475  -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
             +QLE+  + K   +  K  L K+   L+G L+++ + +QE    + ++E Q QE+  K 
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268

Query: 530  ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
               ++   +L   +  L ++    + M  +  GK  +L  D+  ++ Q Q  +  L E  
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328

Query: 583  SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
             +    + +++ LEE+    Q   +E +  K++LE  IS L   L   K          +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388

Query: 635  AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
            A  E +K  + E E L Q+  E     D+LE        +++EL +L   L  Q ++ ++
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 694  LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
            L++ Q     L A E  + ++  + RD    + +E+  K   L +  + AL+A+ E ER 
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 750  ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
               N + KA+  E+      ++   +  L+     L+ Q+++ +  L  + D L   E+ 
Sbjct: 1506 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 810  AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
              R++   + LK G  E ++ +  +   +    LQ+Q  E             LA +  +
Sbjct: 1562 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620

Query: 858  RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
            + E  +++ +LQ + A+        Q  KL    ++F++  E A  +R       +++E 
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680

Query: 908  RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
            + + +E ++  LQE+L + E  +   DL+ +E  E              EK R+ A++ +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 954  LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
            LE  ++LE+ +   +    D+  K  ++A   S++LAT   T  K+            +L
Sbjct: 1741 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797

Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
            +S LH            T+  +  + A+  ++ E+ +R+   A + L + +    EI L 
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857

Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
                R+  EQ++ + EK   G     Q+  ++E+  E  +R      +LQ  LD     N
Sbjct: 1858 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914

Query: 1106 KGGFENVLEEIAELRR 1121
            +     V    ++LRR
Sbjct: 1915 EAMGREVNALKSKLRR 1930



 Score =  130 bits (328), Expect = 1e-29
 Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)

Query: 247  LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
            +++ E +   T++RQ+  E   L+E+E+    L E+K +  E+L+++   + E  + + +
Sbjct: 854  MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 306  LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
            L    +E        EA L+++  E+    L  + + + Q+ ++L    +++    Q+L 
Sbjct: 913  LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970

Query: 358  FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
              K+ A+           A+I K  DE         K   +R +       + +  A + 
Sbjct: 971  LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 414  KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
            +K +   +L+N H ++     +  + E+K     EK     +   S+ H++I   + QI 
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079

Query: 469  RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
                +  + EE +Q                LKKI E    +  L + L       NK  +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 511  EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
            +  DL  ++E  K E+              A +++E+  L+ A+D    S + +   M+ 
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199

Query: 556  QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
            + +   ++L    +Q+++ ++ LD+    + KE  ++                  K LE 
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259

Query: 598  QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
            Q+ E   + +  E  + +L   +  LQ  + ++ G   +A+ +  KL  +  +L  +L +
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 656  ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
                +++E  Q   V+     + +E   L+  L E+ E           +N  L  ++  
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 701  LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
            L  + + +EA              L  +  E     ++LEK     Q E   L  +L+ +
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 748  RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
            RQ + N        E+K+++  +L A+ K++     D+ +  + + ++ +     +   L
Sbjct: 1440 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 804  VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
               EE     +EL R  K+   EM ++ S  D +GK++ +L+K  S+    ++ E  + Q
Sbjct: 1493 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1547

Query: 863  VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
            + E  L++E+   ++   +L    +  +   ER L+AR      Q+E + +Q++ ++H  
Sbjct: 1548 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1601

Query: 920  QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
            +  L+           + ++++G L DL+LQ   A + +E  + QLR+L+ + K     L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 961  EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
            EDA+ S++++F   KE +K  K++         +L  A+   K       ++ +E A  L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721

Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
                    E  R   + AQ   +L   +  +E + + +R   Q+ EQ   E+        
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1775

Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
              S   + E   + +ERQ  E+ ++L  +     S  K     +  +IA+L  +V  +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833



 Score =  101 bits (251), Expect = 1e-20
 Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)

Query: 563  QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
            Q+    ++ Q  E  L +   R  K   E+K+LE+   QLTE +    E L+ + E    
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 901

Query: 620  GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
                    +  +A + +      + E E +L  +   +E+E D+ + +  + + M +++ 
Sbjct: 902  --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953

Query: 679  ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
            +LE  L+E+      LQ  +    A   +LE  + + D + N+L +E     E+++ LT 
Sbjct: 954  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 735  --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
               E+      L K +   ++ + + +   +KE+++ +   KLK  L+ D +   +Q+ D
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 792  FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
             Q  +  +   L + EE     +A   DE+ +K        N       L   ++DLQ+ 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1126

Query: 847  F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
              SE  AR+K E+ +  + E    L+ E+    +  AT Q+E R   E+    L+  ++ 
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1185

Query: 901  DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
            + R HEA++Q+M  +    +  L E L+  +  +   D   Q  ++E   +  +LR L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 957  KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
             K+  + K ++    L+ ++++L+   +  ++ A AEL    D++  L   V  +     
Sbjct: 1246 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1293

Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
              L EAE    KA + A+D+    ++++  Q LL+++  Q      K  V T       E
Sbjct: 1294 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1344

Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
               L + ++ +   +  + R  + L++  SD+K   ++    +  L          I ++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 1134 ADPFKRRGYWY 1144
               ++ +   Y
Sbjct: 1405 TQQYEEKAAAY 1415



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)

Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
            +++ L Q+++Q++ E++ ++  L++ K   ++   E + L+     L++EK  LQE+   
Sbjct: 840  KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
              +  A+ + +        +  +  L ++E  + + +    QL  ++  +   +  +++Q
Sbjct: 899  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
            L+E+  A   LQ E    +  +   + ++L      + L  E+  L++ IS+        
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1015

Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
              EEE K + L  L+N+    I E +++L ++E   Q L+K +   E          + L
Sbjct: 1016 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
            +     LK Q  + E+EL    ++LD         L K+   E  +  LQE+     +  
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
                + KR L E  + L   +E + +  A Q+E  + R  + ++L+     E +  E QV
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
              +++       +L + L + K+  + + K   T+E   ++N + A  L + L Q + E 
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1250

Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
               KK++  Q         D ER + E++D +  L++EV + +   L        +L  D
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1309

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
            + ++   +  L+   E L+E     +N      +L   +  + D+       ++ L    
Sbjct: 1310 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366

Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
              L  QL     K        E L +GK++ +  + +L +Q +             +   
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426

Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
              L  L   L    QL  N EK
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEK 1448



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 128/549 (23%), Positives = 234/549 (42%), Gaps = 133/549 (24%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
            +E+ VS  +D+ +++         +  SKR  E +MEE              ++ ++EEL
Sbjct: 1513 MEDLVSSKDDVGKNVHE-------LEKSKRALETQMEE--------------MKTQLEEL 1551

Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
               +Q  +  K  ++ N+++L  + E +   +  ++                 + R+  R
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---------------EEKRRQLQR 1596

Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
             L E E+EL   +++   A      AK+ L   E D ++LE +A        +A +QLR 
Sbjct: 1597 QLHEYETELEDERKQRALAAA----AKKKL---EGDLKDLELQADSAIKGREEAIKQLRK 1649

Query: 1501 LQADAKD----LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            LQA  KD    LE  +  ++EI         AK+++     KK + L  +L +LQ+D+  
Sbjct: 1650 LQAQMKDFQRELEDARASRDEI------FATAKENE-----KKAKSLEADLMQLQEDLAA 1698

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
            AER                  K+A+LEK         +E+A          EEL     S
Sbjct: 1699 AER----------------ARKQADLEK---------EELA----------EEL----AS 1719

Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
             +  +  LQ+  R  E  + +    + E +  +E +S +  +   Q  +   +L   +  
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779

Query: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736
             +K E   Q + RQ  + +++L           HE++G        V    K+ +A LE 
Sbjct: 1780 AQKNESARQQLERQNKELRSKL-----------HEMEG-------AVKSKFKSTIAALEA 1821

Query: 1737 KL-ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
            K+ +LE  +Q+ Q+ + +    K L ++DK+  E +          VE   K  E  +E+
Sbjct: 1822 KIAQLE--EQVEQEAREKQAATKSLKQKDKKLKEILLQ--------VEDERKMAEQYKEQ 1871

Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
             +    ++ Q KR L  AEE S       +++  N RKLQ+ELD+      ++  +++A+
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEES-------QRINANRRKLQRELDEATESNEAMGREVNAL 1924

Query: 1856 QQQLQEKRE 1864
            + +L+   E
Sbjct: 1925 KSKLRRGNE 1933



 Score = 81.6 bits (200), Expect = 8e-15
 Identities = 117/551 (21%), Positives = 239/551 (43%), Gaps = 73/551 (13%)

Query: 265  ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
            +R  +  +E+ +R  ++ + E + + SK    R   E + ++K  K+L     L++    
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1496

Query: 323  ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
            E K +L   N++LK +  +L  +     +   EL   K  ++ + E +     E  +  +
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556

Query: 381  APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
            A +++    K R + NM A +       QA   +  E   QL+      R     +T+LE
Sbjct: 1557 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1606

Query: 441  DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
            D+ K+ + A     +L  +++  E   L+A    K  EEAI QL+K+    KD   +   
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663

Query: 500  GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
             R            N+ + ++L+   ++LQ +    E A KQ +++  ++A +   S   
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 549  KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
            +++ ++ +K   E ++  + ++ ++ +  ++ +  R+ K T++ + L  +L   +  A  
Sbjct: 1724 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 607  NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
            NE+ ++ LE     + S L E  G +K                       +A + Q   +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842

Query: 641  KLRDEKETLLQRLTEVEQERDQLEIVAMDAEN----MRKELAELESALQEQHEVNASLQQ 696
             L+ + + L + L +VE ER   E     AE     +++   +LE A +E   +NA+ ++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902

Query: 697  TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALG 756
             Q +L       EA       E N LK +L +       E S + +     R+ ++NA G
Sbjct: 1903 LQRELDEATESNEAM----GREVNALKSKLRRGN-----ETSFVPSRRSGGRRVIENADG 1953

Query: 757  KAQFSEEKEQE 767
              + ++ ++ +
Sbjct: 1954 SEEETDTRDAD 1964


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  177 bits (448), Expect = 1e-43
 Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)

Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
            L++ +  +  +   DE++  ++   K  +EL+E ++  ++   E +  +E+ +   E + 
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
            +A+   ++  +  +ELE    E    L + + + + LQA+ K + Q  +  EE L+E   
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
                  + K+ A              D     LSK+++ L E +  L  ++   E     
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
                ++ H  ++ E EV L   +  R ELEKLK            Q+   Q ++A L  Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
            L  K+EEL      +    A    AL+    ++ E   HI +++  L+     + +   Q
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
              +   +L  +K E+E   ++    Q +  +  +  T LK  LD  +  +HE  +Q ++ 
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1206

Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
            +H Q V EL +        K  L+  +Q  +++  ++  + ++L + K+E+E    ++ A
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266

Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
            + + LQS      + + +L +K    + ++     +L  AE  +     ++  L   ++ 
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
             Q+ L +  R KL+       L  + +++Q QL E+ EA  +L+  ++ +   L+ +K+ 
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
            L       + L   + R QK+I     ++E+     +  ++    LQ E+++  + L  Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
              +   L+K++   +  L   K    +   + ++   + + K  + LS   A EE +   
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506

Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
            +E ER                         LEK+    + Q+ E + QL E   EL A +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566

Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
                 +  +   L+ QF  + +  ++Q    +  L+ Q  + E  L +++++ +      
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626

Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
              ++ ++  +EL A    +     +K+L ++Q +  + ++++ +                
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
                  + DL + Q +++ A R        K E+ +E+ +SL   N    E   L A + 
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
             + E  E  +G +E++ + +     +    E+L+           + E+ R++L  +   
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
            L+++L      + E  +K K   + T+ +L  ++  L E V   + +  A++ SL Q + 
Sbjct: 1804 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 2307 SLTE 2310
             L E
Sbjct: 1857 KLKE 1860



 Score =  160 bits (405), Expect = 1e-38
 Identities = 201/1045 (19%), Positives = 453/1045 (43%), Gaps = 126/1045 (12%)

Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
            D+ + L+ ++   + ++  K  +E ++++L   I   DD    L +E+K LE  + +L  
Sbjct: 961  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
             + + +++   +       ES+++ELE+   LK  E    E+E +++ L           
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
               ++++ E    LA+ E EL     +  + + +  +A + + + E    +L+       
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
                KA++Q R L    ++LE  K + E+ L       ++ A ++ +   L K  ++ T 
Sbjct: 1139 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195

Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
                ++Q++++    A       L+  K ++  L   +  LEK  + +  + + +    +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
            ++ HKK++L   Q   +Q+K    E  R    +   K  N +  V  +L E   +  +L 
Sbjct: 1256 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
              ++   +QL           ++ Q +L++ ++ K  +   L  L+ E + LQ      D
Sbjct: 1315 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1357

Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            Q   E+E  Q   LE  +   N+Q    ++K         L+     +E +    +  Q 
Sbjct: 1358 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1406

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             +E L+++ E+     D    KL +TK  L    ++  ++  N  +L  N+ K Q++ DQ
Sbjct: 1407 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
            L  ++ ++ +  +  + + + +     +    LA   +    AK++L  T K     + +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
                + D+ +  +  E  ++  ET+ +    QL+ L++E+   E+ KL+L V  + +  +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
             +++ ++ + + E  +  L+ Q H+ E EL D+          K KL+  L  + L A+ 
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
             ++  +E  +    L+  +   +R+L +      E        +K+A S+ AD   L+  
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702

Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
                        L + + AE+  +SL  + AL+ ++ +LE  + + ++E   +++E   +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1759

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
            E ++    +  ++  +  N++  E +  +K  + ++ LER+  E+   +  ++  VK + 
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
            ++++  L   + +L   +E   +     +   +SLK+           ++KL    + + 
Sbjct: 1820 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1866

Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
            DE    E  +E+      R+K      + +Q E   +  ++       L+R++D      
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1915

Query: 2289 TSTSADSASSPSLSQLESSLTEDSQ 2313
             +T ++ A    ++ L+S L   ++
Sbjct: 1916 EATESNEAMGREVNALKSKLRRGNE 1940



 Score =  135 bits (340), Expect = 5e-31
 Identities = 193/934 (20%), Positives = 393/934 (42%), Gaps = 137/934 (14%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            S + ++   LK +++  + +   KR+ E +  + H  I DL       + ++ EL   + 
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-------QAQIAELKMQLA 1093

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
            K++++       ++  + +     +LK   ++   I  +++ L   R+   +A++   + 
Sbjct: 1094 KKEEELQAALARLDDEIAQKN--NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 1446 ESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA 1505
              EL   K          T+ + +L  T +  E   +R QE  V     D++ RS +A  
Sbjct: 1152 GEELEALK----------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 1506 KDLEQ-HKIKQEEILKEINKIVAAK---DSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 1561
            +++ Q H    EE+ +++ +   AK   D + Q L K+   L  EL+ L +    A++  
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----AKQEV 1257

Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQ----QQEMAVLDRQLGHKKEELHLLQGSM 1617
            +H  + L+     LQ+K ++ E+ ++++  +    Q E+  +   L   + +   L   +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317

Query: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
                + LQ+   L + E  +K N    V + L +L  ++  L  Q+ E        KQ +
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEA----KQNL 1369

Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENH----ELQGLKLQHDQRVS---ELEKTQ 1730
            E+    L + L    K   +  + ++ L+        E++ L  Q++++ +   +LEKT+
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 1731 VAVLEEK----LELENLQQ-ISQQQKGEIEWQKQLLE-----------RDKREIERMTAE 1774
              + +E     ++L+N +Q +S  +K + ++ + L E           RD+ E E    E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 1775 S------RALQSCVEC----------LSKEKEDL-QEKCDIWEK--KLAQTKRVLAAAEE 1815
            +      RAL+  +E           L  E EDL   K D+ +   +L ++KR L    E
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 1816 NSKMEQSNLE-----------KLELNVRKLQ-------QELDQLNRDKL-SLHNDISAMQ 1856
              K +   LE           +LE+N++ L+       Q  D+ N +K   L   +   +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
             +L+++R+           ++  L   +       K ++  + +  +LQ  + ++    E
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 1917 DCQ----------KEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE----- 1961
            D +          KE E K + L+    +++E+ L   ++      L+KE  +EE     
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQED-LAAAERARKQADLEKEELAEELASSL 1728

Query: 1962 ---SKLETSKVTLKEQQHQLEKELTDQKSKL----DQVLSKVLAAEERVRTLQEEERWCE 2014
               + L+  K  L+ +  QLE+EL +++  +    D+V      AE+    L  E    +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788

Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA-DSMRADFSLLRNQFLTERKKAEKQV 2073
              E    Q +RQ  E   +L E  G + +  K    ++ A  + L  Q   E ++ +   
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 2074 ASLKEALKIQRSQL-----EKNLLEQKQENS--------CIQKEMATIELVAQDNHERAR 2120
             SLK+  K  +  L     E+ + EQ +E +         +++++   E  +Q  +   R
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 2121 RLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
            +L +EL++       + +++   K   RR  E S
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942



 Score =  134 bits (336), Expect = 1e-30
 Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)

Query: 285  ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
            + EE+++K+    +  + Q K    LKE      Q  EE   L+  L  + EL  +    
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 342  LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
              R   K+ ELE+ L  ++++A+ E                                   
Sbjct: 917  RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 942

Query: 402  SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
                D  Q +Q ++ +  +Q+ +          L+ QLE++E   +K+      A+ ++ 
Sbjct: 943  ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 455  ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
            +L DEI   + Q  + ++E K LEE I     + A ++   K L+   +L NK      +
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1045

Query: 515  LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
            LE++++K+++     ++E++ L+  ++  D+ D                    ++Q   L
Sbjct: 1046 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1081

Query: 575  ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
            ++++ E+  ++AK+ EE++    +L +     N ALKK  +LEG IS LQE L + +   
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 633  TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
             +A+ + R L +E E L    TE+E   D             +E+  L+ AL E      
Sbjct: 1142 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1192

Query: 693  SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
                   +  ++EA+++           +L E+LE+  R         +A L+K +Q L 
Sbjct: 1193 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1236

Query: 753  NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
                        E+EN++L  +L+        ++     L+ Q+++ Q+  +   DG   
Sbjct: 1237 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1281

Query: 806  PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
              E+  +V +L+ +++  TG +N     +  L K +A L  Q     E+L     ++   
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341

Query: 862  QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
              + R+L+EE    Q++L   + E +Q  ER + + +N      + ++Q   + +  L+E
Sbjct: 1342 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 922  NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
              K  + EI+ LT        ++ E   A   +LEK K     +  + V  LD +   + 
Sbjct: 1400 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 978  KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
             L+K     D+L   E  I+            K   ER     EA     KA   AR L 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1500

Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
             A EA+ EL +     K E   L   K  VG   +        L   ME  +T++  L++
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560

Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
             L  T              KG FE  L    E+  E RR++  Q ++Y + + D  K+R
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619



 Score =  131 bits (329), Expect = 9e-30
 Identities = 218/976 (22%), Positives = 424/976 (43%), Gaps = 126/976 (12%)

Query: 247  LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
            ++ LE + +   D+      ER  LEE +  L  +L   E+K     +LK+K    + E+
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046

Query: 301  KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
            + + K  +  ++E    K+  E   SD + +   L+ +  EL     K+ E E + A  +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1105

Query: 361  IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
            +D +    N    +  E++    D    +   R  RN    E    D  + ++  K E +
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1163

Query: 420  EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
            + L +        T    +L  K E++++  +  L E    H+ ++++  Q+  +A EE 
Sbjct: 1164 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 475  -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
             +QLE+  + K   +  K  L K+   L+G L+++ + +QE    + ++E Q QE+  K 
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275

Query: 530  ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
               ++   +L   +  L ++    + M  +  GK  +L  D+  ++ Q Q  +  L E  
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335

Query: 583  SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
             +    + +++ LEE+    Q   +E +  K++LE  IS L   L   K          +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395

Query: 635  AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
            A  E +K  + E E L Q+  E     D+LE        +++EL +L   L  Q ++ ++
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 694  LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
            L++ Q     L A E  + ++  + RD    + +E+  K   L +  + AL+A+ E ER 
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 750  ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
               N + KA+  E+      ++   +  L+     L+ Q+++ +  L  + D L   E+ 
Sbjct: 1513 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 810  AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
              R++   + LK G  E ++ +  +   +    LQ+Q  E             LA +  +
Sbjct: 1569 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627

Query: 858  RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
            + E  +++ +LQ + A+        Q  KL    ++F++  E A  +R       +++E 
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687

Query: 908  RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
            + + +E ++  LQE+L + E  +   DL+ +E  E              EK R+ A++ +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 954  LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
            LE  ++LE+ +   +    D+  K  ++A   S++LAT   T  K+            +L
Sbjct: 1748 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804

Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
            +S LH            T+  +  + A+  ++ E+ +R+   A + L + +    EI L 
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864

Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
                R+  EQ++ + EK   G     Q+  ++E+  E  +R      +LQ  LD     N
Sbjct: 1865 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921

Query: 1106 KGGFENVLEEIAELRR 1121
            +     V    ++LRR
Sbjct: 1922 EAMGREVNALKSKLRR 1937



 Score =  130 bits (328), Expect = 1e-29
 Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)

Query: 247  LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
            +++ E +   T++RQ+  E   L+E+E+    L E+K +  E+L+++   + E  + + +
Sbjct: 861  MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 306  LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
            L    +E        EA L+++  E+    L  + + + Q+ ++L    +++    Q+L 
Sbjct: 920  LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

Query: 358  FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
              K+ A+           A+I K  DE         K   +R +       + +  A + 
Sbjct: 978  LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 414  KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
            +K +   +L+N H ++     +  + E+K     EK     +   S+ H++I   + QI 
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086

Query: 469  RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
                +  + EE +Q                LKKI E    +  L + L       NK  +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 511  EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
            +  DL  ++E  K E+              A +++E+  L+ A+D    S + +   M+ 
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

Query: 556  QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
            + +   ++L    +Q+++ ++ LD+    + KE  ++                  K LE 
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266

Query: 598  QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
            Q+ E   + +  E  + +L   +  LQ  + ++ G   +A+ +  KL  +  +L  +L +
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 656  ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
                +++E  Q   V+     + +E   L+  L E+ E           +N  L  ++  
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 701  LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
            L  + + +EA              L  +  E     ++LEK     Q E   L  +L+ +
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 748  RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
            RQ + N        E+K+++  +L A+ K++     D+ +  + + ++ +     +   L
Sbjct: 1447 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 804  VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
               EE     +EL R  K+   EM ++ S  D +GK++ +L+K  S+    ++ E  + Q
Sbjct: 1500 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1554

Query: 863  VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
            + E  L++E+   ++   +L    +  +   ER L+AR      Q+E + +Q++ ++H  
Sbjct: 1555 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1608

Query: 920  QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
            +  L+           + ++++G L DL+LQ   A + +E  + QLR+L+ + K     L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 961  EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
            EDA+ S++++F   KE +K  K++         +L  A+   K       ++ +E A  L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728

Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
                    E  R   + AQ   +L   +  +E + + +R   Q+ EQ   E+        
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1782

Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
              S   + E   + +ERQ  E+ ++L  +     S  K     +  +IA+L  +V  +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840



 Score =  101 bits (251), Expect = 1e-20
 Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)

Query: 563  QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
            Q+    ++ Q  E  L +   R  K   E+K+LE+   QLTE +    E L+ + E    
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 908

Query: 620  GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
                    +  +A + +      + E E +L  +   +E+E D+ + +  + + M +++ 
Sbjct: 909  --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960

Query: 679  ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
            +LE  L+E+      LQ  +    A   +LE  + + D + N+L +E     E+++ LT 
Sbjct: 961  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 735  --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
               E+      L K +   ++ + + +   +KE+++ +   KLK  L+ D +   +Q+ D
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 792  FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
             Q  +  +   L + EE     +A   DE+ +K        N       L   ++DLQ+ 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1133

Query: 847  F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
              SE  AR+K E+ +  + E    L+ E+    +  AT Q+E R   E+    L+  ++ 
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1192

Query: 901  DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
            + R HEA++Q+M  +    +  L E L+  +  +   D   Q  ++E   +  +LR L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 957  KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
             K+  + K ++    L+ ++++L+   +  ++ A AEL    D++  L   V  +     
Sbjct: 1253 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1300

Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
              L EAE    KA + A+D+    ++++  Q LL+++  Q      K  V T       E
Sbjct: 1301 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1351

Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
               L + ++ +   +  + R  + L++  SD+K   ++    +  L          I ++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 1134 ADPFKRRGYWY 1144
               ++ +   Y
Sbjct: 1412 TQQYEEKAAAY 1422



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)

Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
            +++ L Q+++Q++ E++ ++  L++ K   ++   E + L+     L++EK  LQE+   
Sbjct: 847  KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
              +  A+ + +        +  +  L ++E  + + +    QL  ++  +   +  +++Q
Sbjct: 906  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
            L+E+  A   LQ E    +  +   + ++L      + L  E+  L++ IS+        
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1022

Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
              EEE K + L  L+N+    I E +++L ++E   Q L+K +   E          + L
Sbjct: 1023 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
            +     LK Q  + E+EL    ++LD         L K+   E  +  LQE+     +  
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
                + KR L E  + L   +E + +  A Q+E  + R  + ++L+     E +  E QV
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
              +++       +L + L + K+  + + K   T+E   ++N + A  L + L Q + E 
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1257

Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
               KK++  Q         D ER + E++D +  L++EV + +   L        +L  D
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1316

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
            + ++   +  L+   E L+E     +N      +L   +  + D+       ++ L    
Sbjct: 1317 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
              L  QL     K        E L +GK++ +  + +L +Q +             +   
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
              L  L   L    QL  N EK
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEK 1455



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 128/549 (23%), Positives = 234/549 (42%), Gaps = 133/549 (24%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
            +E+ VS  +D+ +++         +  SKR  E +MEE              ++ ++EEL
Sbjct: 1520 MEDLVSSKDDVGKNVHE-------LEKSKRALETQMEE--------------MKTQLEEL 1558

Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
               +Q  +  K  ++ N+++L  + E +   +  ++                 + R+  R
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---------------EEKRRQLQR 1603

Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
             L E E+EL   +++   A      AK+ L   E D ++LE +A        +A +QLR 
Sbjct: 1604 QLHEYETELEDERKQRALAAA----AKKKL---EGDLKDLELQADSAIKGREEAIKQLRK 1656

Query: 1501 LQADAKD----LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            LQA  KD    LE  +  ++EI         AK+++     KK + L  +L +LQ+D+  
Sbjct: 1657 LQAQMKDFQRELEDARASRDEI------FATAKENE-----KKAKSLEADLMQLQEDLAA 1705

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
            AER                  K+A+LEK         +E+A          EEL     S
Sbjct: 1706 AER----------------ARKQADLEK---------EELA----------EEL----AS 1726

Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
             +  +  LQ+  R  E  + +    + E +  +E +S +  +   Q  +   +L   +  
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786

Query: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736
             +K E   Q + RQ  + +++L           HE++G        V    K+ +A LE 
Sbjct: 1787 AQKNESARQQLERQNKELRSKL-----------HEMEG-------AVKSKFKSTIAALEA 1828

Query: 1737 KL-ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
            K+ +LE  +Q+ Q+ + +    K L ++DK+  E +          VE   K  E  +E+
Sbjct: 1829 KIAQLE--EQVEQEAREKQAATKSLKQKDKKLKEILLQ--------VEDERKMAEQYKEQ 1878

Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
             +    ++ Q KR L  AEE S       +++  N RKLQ+ELD+      ++  +++A+
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEES-------QRINANRRKLQRELDEATESNEAMGREVNAL 1931

Query: 1856 QQQLQEKRE 1864
            + +L+   E
Sbjct: 1932 KSKLRRGNE 1940



 Score = 81.6 bits (200), Expect = 8e-15
 Identities = 117/551 (21%), Positives = 239/551 (43%), Gaps = 73/551 (13%)

Query: 265  ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
            +R  +  +E+ +R  ++ + E + + SK    R   E + ++K  K+L     L++    
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1503

Query: 323  ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
            E K +L   N++LK +  +L  +     +   EL   K  ++ + E +     E  +  +
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563

Query: 381  APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
            A +++    K R + NM A +       QA   +  E   QL+      R     +T+LE
Sbjct: 1564 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1613

Query: 441  DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
            D+ K+ + A     +L  +++  E   L+A    K  EEAI QL+K+    KD   +   
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670

Query: 500  GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
             R            N+ + ++L+   ++LQ +    E A KQ +++  ++A +   S   
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 549  KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
            +++ ++ +K   E ++  + ++ ++ +  ++ +  R+ K T++ + L  +L   +  A  
Sbjct: 1731 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 607  NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
            NE+ ++ LE     + S L E  G +K                       +A + Q   +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849

Query: 641  KLRDEKETLLQRLTEVEQERDQLEIVAMDAEN----MRKELAELESALQEQHEVNASLQQ 696
             L+ + + L + L +VE ER   E     AE     +++   +LE A +E   +NA+ ++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909

Query: 697  TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALG 756
             Q +L       EA       E N LK +L +       E S + +     R+ ++NA G
Sbjct: 1910 LQRELDEATESNEAM----GREVNALKSKLRRGN-----ETSFVPSRRSGGRRVIENADG 1960

Query: 757  KAQFSEEKEQE 767
              + ++ ++ +
Sbjct: 1961 SEEETDTRDAD 1971


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  177 bits (448), Expect = 1e-43
 Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)

Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
            L++ +  +  +   DE++  ++   K  +EL+E ++  ++   E +  +E+ +   E + 
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
            +A+   ++  +  +ELE    E    L + + + + LQA+ K + Q  +  EE L+E   
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
                  + K+ A              D     LSK+++ L E +  L  ++   E     
Sbjct: 972  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031

Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
                ++ H  ++ E EV L   +  R ELEKLK            Q+   Q ++A L  Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
            L  K+EEL      +    A    AL+    ++ E   HI +++  L+     + +   Q
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
              +   +L  +K E+E   ++    Q +  +  +  T LK  LD  +  +HE  +Q ++ 
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1206

Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
            +H Q V EL +        K  L+  +Q  +++  ++  + ++L + K+E+E    ++ A
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266

Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
            + + LQS      + + +L +K    + ++     +L  AE  +     ++  L   ++ 
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
             Q+ L +  R KL+       L  + +++Q QL E+ EA  +L+  ++ +   L+ +K+ 
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
            L       + L   + R QK+I     ++E+     +  ++    LQ E+++  + L  Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
              +   L+K++   +  L   K    +   + ++   + + K  + LS   A EE +   
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506

Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
            +E ER                         LEK+    + Q+ E + QL E   EL A +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566

Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
                 +  +   L+ QF  + +  ++Q    +  L+ Q  + E  L +++++ +      
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626

Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
              ++ ++  +EL A    +     +K+L ++Q +  + ++++ +                
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
                  + DL + Q +++ A R        K E+ +E+ +SL   N    E   L A + 
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
             + E  E  +G +E++ + +     +    E+L+           + E+ R++L  +   
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
            L+++L      + E  +K K   + T+ +L  ++  L E V   + +  A++ SL Q + 
Sbjct: 1804 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 2307 SLTE 2310
             L E
Sbjct: 1857 KLKE 1860



 Score =  160 bits (404), Expect = 2e-38
 Identities = 201/1040 (19%), Positives = 451/1040 (43%), Gaps = 126/1040 (12%)

Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
            D+ + L+ ++   + ++  K  +E ++++L   I   DD    L +E+K LE  + +L  
Sbjct: 961  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
             + + +++   +       ES+++ELE+   LK  E    E+E +++ L           
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
               ++++ E    LA+ E EL     +  + + +  +A + + + E    +L+       
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
                KA++Q R L    ++LE  K + E+ L       ++ A ++ +   L K  ++ T 
Sbjct: 1139 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195

Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
                ++Q++++    A       L+  K ++  L   +  LEK  + +  + + +    +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
            ++ HKK++L   Q   +Q+K    E  R    +   K  N +  V  +L E   +  +L 
Sbjct: 1256 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
              ++   +QL           ++ Q +L++ ++ K  +   L  L+ E + LQ      D
Sbjct: 1315 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1357

Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            Q   E+E  Q   LE  +   N+Q    ++K         L+     +E +    +  Q 
Sbjct: 1358 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1406

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             +E L+++ E+     D    KL +TK  L    ++  ++  N  +L  N+ K Q++ DQ
Sbjct: 1407 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
            L  ++ ++ +  +  + + + +     +    LA   +    AK++L  T K     + +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
                + D+ +  +  E  ++  ET+ +    QL+ L++E+   E+ KL+L V  + +  +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
             +++ ++ + + E  +  L+ Q H+ E EL D+          K KL+  L  + L A+ 
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
             ++  +E  +    L+  +   +R+L +      E        +K+A S+ AD   L+  
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702

Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
                        L + + AE+  +SL  + AL+ ++ +LE  + + ++E   +++E   +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1759

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
            E ++    +  ++  +  N++  E +  +K  + ++ LER+  E+   +  ++  VK + 
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
            ++++  L   + +L   +E   +     +   +SLK+           ++KL    + + 
Sbjct: 1820 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1866

Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
            DE    E  +E+      R+K      + +Q E   +  ++       L+R++D      
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1915

Query: 2289 TSTSADSASSPSLSQLESSL 2308
             +T ++ A    ++ L+S L
Sbjct: 1916 EATESNEAMGREVNALKSKL 1935



 Score =  134 bits (336), Expect = 1e-30
 Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)

Query: 285  ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
            + EE+++K+    +  + Q K    LKE      Q  EE   L+  L  + EL  +    
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 342  LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
              R   K+ ELE+ L  ++++A+ E                                   
Sbjct: 917  RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 942

Query: 402  SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
                D  Q +Q ++ +  +Q+ +          L+ QLE++E   +K+      A+ ++ 
Sbjct: 943  ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 455  ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
            +L DEI   + Q  + ++E K LEE I     + A ++   K L+   +L NK      +
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1045

Query: 515  LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
            LE++++K+++     ++E++ L+  ++  D+ D                    ++Q   L
Sbjct: 1046 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1081

Query: 575  ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
            ++++ E+  ++AK+ EE++    +L +     N ALKK  +LEG IS LQE L + +   
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 633  TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
             +A+ + R L +E E L    TE+E   D             +E+  L+ AL E      
Sbjct: 1142 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1192

Query: 693  SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
                   +  ++EA+++           +L E+LE+  R         +A L+K +Q L 
Sbjct: 1193 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1236

Query: 753  NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
                        E+EN++L  +L+        ++     L+ Q+++ Q+  +   DG   
Sbjct: 1237 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1281

Query: 806  PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
              E+  +V +L+ +++  TG +N     +  L K +A L  Q     E+L     ++   
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341

Query: 862  QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
              + R+L+EE    Q++L   + E +Q  ER + + +N      + ++Q   + +  L+E
Sbjct: 1342 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 922  NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
              K  + EI+ LT        ++ E   A   +LEK K     +  + V  LD +   + 
Sbjct: 1400 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 978  KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
             L+K     D+L   E  I+            K   ER     EA     KA   AR L 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1500

Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
             A EA+ EL +     K E   L   K  VG   +        L   ME  +T++  L++
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560

Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
             L  T              KG FE  L    E+  E RR++  Q ++Y + + D  K+R
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619



 Score =  130 bits (328), Expect = 1e-29
 Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)

Query: 247  LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
            +++ E +   T++RQ+  E   L+E+E+    L E+K +  E+L+++   + E  + + +
Sbjct: 861  MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 306  LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
            L    +E        EA L+++  E+    L  + + + Q+ ++L    +++    Q+L 
Sbjct: 920  LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

Query: 358  FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
              K+ A+           A+I K  DE         K   +R +       + +  A + 
Sbjct: 978  LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 414  KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
            +K +   +L+N H ++     +  + E+K     EK     +   S+ H++I   + QI 
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086

Query: 469  RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
                +  + EE +Q                LKKI E    +  L + L       NK  +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 511  EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
            +  DL  ++E  K E+              A +++E+  L+ A+D    S + +   M+ 
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

Query: 556  QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
            + +   ++L    +Q+++ ++ LD+    + KE  ++                  K LE 
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266

Query: 598  QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
            Q+ E   + +  E  + +L   +  LQ  + ++ G   +A+ +  KL  +  +L  +L +
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 656  ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
                +++E  Q   V+     + +E   L+  L E+ E           +N  L  ++  
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 701  LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
            L  + + +EA              L  +  E     ++LEK     Q E   L  +L+ +
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 748  RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
            RQ + N        E+K+++  +L A+ K++     D+ +  + + ++ +     +   L
Sbjct: 1447 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 804  VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
               EE     +EL R  K+   EM ++ S  D +GK++ +L+K  S+    ++ E  + Q
Sbjct: 1500 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1554

Query: 863  VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
            + E  L++E+   ++   +L    +  +   ER L+AR      Q+E + +Q++ ++H  
Sbjct: 1555 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1608

Query: 920  QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
            +  L+           + ++++G L DL+LQ   A + +E  + QLR+L+ + K     L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 961  EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
            EDA+ S++++F   KE +K  K++         +L  A+   K       ++ +E A  L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728

Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
                    E  R   + AQ   +L   +  +E + + +R   Q+ EQ   E+        
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1782

Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
              S   + E   + +ERQ  E+ ++L  +     S  K     +  +IA+L  +V  +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840



 Score =  129 bits (325), Expect = 3e-29
 Identities = 214/961 (22%), Positives = 418/961 (43%), Gaps = 126/961 (13%)

Query: 247  LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
            ++ LE + +   D+      ER  LEE +  L  +L   E+K     +LK+K    + E+
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046

Query: 301  KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
            + + K  +  ++E    K+  E   SD + +   L+ +  EL     K+ E E + A  +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1105

Query: 361  IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
            +D +    N    +  E++    D    +   R  RN    E    D  + ++  K E +
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1163

Query: 420  EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
            + L +        T    +L  K E++++  +  L E    H+ ++++  Q+  +A EE 
Sbjct: 1164 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 475  -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
             +QLE+  + K   +  K  L K+   L+G L+++ + +QE    + ++E Q QE+  K 
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275

Query: 530  ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
               ++   +L   +  L ++    + M  +  GK  +L  D+  ++ Q Q  +  L E  
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335

Query: 583  SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
             +    + +++ LEE+    Q   +E +  K++LE  IS L   L   K          +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395

Query: 635  AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
            A  E +K  + E E L Q+  E     D+LE        +++EL +L   L  Q ++ ++
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 694  LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
            L++ Q     L A E  + ++  + RD    + +E+  K   L +  + AL+A+ E ER 
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 750  ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
               N + KA+  E+      ++   +  L+     L+ Q+++ +  L  + D L   E+ 
Sbjct: 1513 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 810  AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
              R++   + LK G  E ++ +  +   +    LQ+Q  E             LA +  +
Sbjct: 1569 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627

Query: 858  RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
            + E  +++ +LQ + A+        Q  KL    ++F++  E A  +R       +++E 
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687

Query: 908  RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
            + + +E ++  LQE+L + E  +   DL+ +E  E              EK R+ A++ +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 954  LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
            LE  ++LE+ +   +    D+  K  ++A   S++LAT   T  K+            +L
Sbjct: 1748 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804

Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
            +S LH            T+  +  + A+  ++ E+ +R+   A + L + +    EI L 
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864

Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
                R+  EQ++ + EK   G     Q+  ++E+  E  +R      +LQ  LD     N
Sbjct: 1865 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921

Query: 1106 K 1106
            +
Sbjct: 1922 E 1922



 Score =  129 bits (324), Expect = 3e-29
 Identities = 221/1024 (21%), Positives = 443/1024 (43%), Gaps = 145/1024 (14%)

Query: 85   EALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLD 144
            EA IKKL  +D + ++   N  LSK+            K ++  + +L+ NL  + EK  
Sbjct: 984  EAKIKKL--EDEILVMDDQNNKLSKE-----------RKLLEERISDLTTNLAEEEEKAK 1030

Query: 145  KLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNK 204
             L KL+  N   + IS++E       L+K   +  E+E +   L               +
Sbjct: 1031 NLTKLK--NKHESMISELE-----VRLKKEEKSRQELEKLKRKLEGDASDFH------EQ 1077

Query: 205  ISSLQ-DISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
            I+ LQ  I++LK +Q       ++  +  L   +      L+ +  LEG     Q+  ++
Sbjct: 1078 IADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 264  FERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323
             ER +  + E+ +RDL +   E E LK++    L+    Q +L    ++E  + K++ +E
Sbjct: 1137 -ERAARNKAEKQKRDLGE---ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 324  LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD 383
                   + + ++QK  +      +Q E      F +  A  +  N    E    D A  
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLE-----QFKRAKANLDK-NKQTLEKENADLA-G 1245

Query: 384  ESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE 443
            E   +G+++                Q V+ KK +                 L+ Q+++ +
Sbjct: 1246 ELRVLGQAK----------------QEVEHKKKK-----------------LEAQVQELQ 1272

Query: 444  KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE-EAIQLKK----ISEAGKD---LLY 495
             K S  +   +EL+D++ K + ++   T    + E +AI+L K    +S   +D   LL 
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332

Query: 496  KQLSGRLQLVNKLRQ---EALDLELQMEKQKQEIAGKQKEIKDLQIAI-DSLDSKDPKHS 551
            ++   +L +  KLRQ   E   L+ Q++++ +     ++ I  L I + DS        S
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392

Query: 552  HMKAQKSGK---EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL-TEGQIAAN 607
             ++A + GK   +++++ + +QY++  +  D++     +  +E+ DL   L  + Q+ +N
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 608  -EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI- 665
             E  ++  + +++  +        +  +A+ E R+   +  +L + L E  + +++LE  
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 666  ----------VAMDAENMRKELAELES---ALQEQ-HEVNASLQQTQGDLSAYE-AELEA 710
                      +    +++ K + ELE    AL+ Q  E+   L++ + +L A E A+L  
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 711  RLNL--------RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE 762
             +N+        RD +A   + E ++     QL +   + E E++++AL  A  K    +
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632

Query: 763  EKE---QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK 819
             K+   Q +S +  + + ++    L + Q+KDFQ  L    D     +E+ A   E  +K
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELE---DARASRDEIFATAKENEKK 1688

Query: 820  LKLGTGEMNIHSPSDVLG----KSLADLQKQ-FSEILARSKWERDEAQVRERKLQEEMAL 874
             K    ++ +    D+      +  ADL+K+  +E LA S   R+  Q  +R+L+  +A 
Sbjct: 1689 AKSLEADL-MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 875  QQEKLATGQEEFRQACERALEARMNFDK------------RQHEARIQQMENEIHYLQEN 922
             +E+L   Q       +R  +A    ++            +++E+  QQ+E +   L+  
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 923  LKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKA 982
            L  ME   G    + +      E  +AQL E  +++  E   + + +   DK+LK++   
Sbjct: 1808 LHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864

Query: 983  VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
            V    K+A       K+Q +  +  V ++ ++  E  +E++R +    +  R+L  A   
Sbjct: 1865 VEDERKMAEQY----KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920

Query: 1043 IELL 1046
             E +
Sbjct: 1921 NEAM 1924



 Score =  103 bits (258), Expect = 2e-21
 Identities = 139/642 (21%), Positives = 279/642 (43%), Gaps = 134/642 (20%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            S+L+D  + L+ + R++  +    RQ E+E   L   +D+ ++ K++LE  +  L+  + 
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 1386 KRQQQKDFIDGNVESL-----MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL----- 1435
              +++       VE+L       + EIE   + +E+     + +EKT  + + EL     
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 1436 ----------------READRLLAEAE------------SELSCTKEKTK-----NAVEK 1462
                            R+ D+LLAE +            +E    +++TK      A+E+
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 1463 FTDAKRSLLQT----ESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI 1518
              +AK  L +T    +++ E+L     +   N+ + ++  R+L+     +E+ K + EE+
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEEL 1558

Query: 1519 LKEINKIVAAK--------------DSDFQCLSKKKEKLTEELQKL--QKDIEMAERNED 1562
              E+     AK              + D Q   ++ E+   +LQ+   + + E+ +  + 
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618

Query: 1563 HHLQVLKE-------SEVLLQAKRA---------ELEKLKSQVTSQQQEM----AVLDRQ 1602
              L    +        ++ LQA  A         +L KL++Q+   Q+E+    A  D  
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678

Query: 1603 LGHKKE---ELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
                KE   +   L+  ++Q + DL  A R  +    EK       + L EEL+      
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-------EELAEELASSLSGR 1731

Query: 1660 NVQISERK---TQLTLIKQEIEKEEENLQVV---LRQMSKHKTELKNIL----------- 1702
            N    E++    ++  +++E+E+E+ N++ +   +R+ ++   +L N L           
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791

Query: 1703 ---DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL-ELENLQQISQQQKGEIEWQK 1758
                 L+ +N EL+    + +  V    K+ +A LE K+ +LE  +Q+ Q+ + +    K
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE--EQVEQEAREKQAATK 1849

Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
             L ++DK+  E +          VE   K  E  +E+ +    ++ Q KR L  AEE S 
Sbjct: 1850 SLKQKDKKLKEILLQ--------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES- 1900

Query: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
                  +++  N RKLQ+ELD+      ++  +++A++ +L+
Sbjct: 1901 ------QRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  101 bits (251), Expect = 1e-20
 Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)

Query: 563  QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
            Q+    ++ Q  E  L +   R  K   E+K+LE+   QLTE +    E L+ + E    
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 908

Query: 620  GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
                    +  +A + +      + E E +L  +   +E+E D+ + +  + + M +++ 
Sbjct: 909  --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960

Query: 679  ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
            +LE  L+E+      LQ  +    A   +LE  + + D + N+L +E     E+++ LT 
Sbjct: 961  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 735  --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
               E+      L K +   ++ + + +   +KE+++ +   KLK  L+ D +   +Q+ D
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 792  FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
             Q  +  +   L + EE     +A   DE+ +K        N       L   ++DLQ+ 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1133

Query: 847  F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
              SE  AR+K E+ +  + E    L+ E+    +  AT Q+E R   E+    L+  ++ 
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1192

Query: 901  DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
            + R HEA++Q+M  +    +  L E L+  +  +   D   Q  ++E   +  +LR L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 957  KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
             K+  + K ++    L+ ++++L+   +  ++ A AEL    D++  L   V  +     
Sbjct: 1253 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1300

Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
              L EAE    KA + A+D+    ++++  Q LL+++  Q      K  V T       E
Sbjct: 1301 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1351

Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
               L + ++ +   +  + R  + L++  SD+K   ++    +  L          I ++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 1134 ADPFKRRGYWY 1144
               ++ +   Y
Sbjct: 1412 TQQYEEKAAAY 1422



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)

Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
            +++ L Q+++Q++ E++ ++  L++ K   ++   E + L+     L++EK  LQE+   
Sbjct: 847  KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
              +  A+ + +        +  +  L ++E  + + +    QL  ++  +   +  +++Q
Sbjct: 906  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
            L+E+  A   LQ E    +  +   + ++L      + L  E+  L++ IS+        
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1022

Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
              EEE K + L  L+N+    I E +++L ++E   Q L+K +   E          + L
Sbjct: 1023 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
            +     LK Q  + E+EL    ++LD         L K+   E  +  LQE+     +  
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
                + KR L E  + L   +E + +  A Q+E  + R  + ++L+     E +  E QV
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
              +++       +L + L + K+  + + K   T+E   ++N + A  L + L Q + E 
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1257

Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
               KK++  Q         D ER + E++D +  L++EV + +   L        +L  D
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1316

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
            + ++   +  L+   E L+E     +N      +L   +  + D+       ++ L    
Sbjct: 1317 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
              L  QL     K        E L +GK++ +  + +L +Q +             +   
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
              L  L   L    QL  N EK
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEK 1455



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 111/510 (21%), Positives = 221/510 (43%), Gaps = 68/510 (13%)

Query: 265  ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
            +R  +  +E+ +R  ++ + E + + SK    R   E + ++K  K+L     L++    
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1503

Query: 323  ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
            E K +L   N++LK +  +L  +     +   EL   K  ++ + E +     E  +  +
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563

Query: 381  APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
            A +++    K R + NM A +       QA   +  E   QL+      R     +T+LE
Sbjct: 1564 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1613

Query: 441  DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
            D+ K+ + A     +L  +++  E   L+A    K  EEAI QL+K+    KD   +   
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670

Query: 500  GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
             R            N+ + ++L+   ++LQ +    E A KQ +++  ++A +   S   
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 549  KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
            +++ ++ +K   E ++  + ++ ++ +  ++ +  R+ K T++ + L  +L   +  A  
Sbjct: 1731 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 607  NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
            NE+ ++ LE     + S L E  G +K                       +A + Q   +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849

Query: 641  KLRDEKETLLQRLTEVEQERDQLEIVAMDAE----NMRKELAELESALQEQHEVNASLQQ 696
             L+ + + L + L +VE ER   E     AE     +++   +LE A +E   +NA+ ++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909

Query: 697  TQGDLSAYEAELEARLNLRDAEANQLKEEL 726
             Q +L       EA       E N LK +L
Sbjct: 1910 LQRELDEATESNEA----MGREVNALKSKL 1935


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  177 bits (448), Expect = 1e-43
 Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)

Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
            L++ +  +  +   DE++  ++   K  +EL+E ++  ++   E +  +E+ +   E + 
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
            +A+   ++  +  +ELE    E    L + + + + LQA+ K + Q  +  EE L+E   
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
                  + K+ A              D     LSK+++ L E +  L  ++   E     
Sbjct: 965  ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024

Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
                ++ H  ++ E EV L   +  R ELEKLK            Q+   Q ++A L  Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
            L  K+EEL      +    A    AL+    ++ E   HI +++  L+     + +   Q
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
              +   +L  +K E+E   ++    Q +  +  +  T LK  LD  +  +HE  +Q ++ 
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1199

Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
            +H Q V EL +        K  L+  +Q  +++  ++  + ++L + K+E+E    ++ A
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259

Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
            + + LQS      + + +L +K    + ++     +L  AE  +     ++  L   ++ 
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
             Q+ L +  R KL+       L  + +++Q QL E+ EA  +L+  ++ +   L+ +K+ 
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
            L       + L   + R QK+I     ++E+     +  ++    LQ E+++  + L  Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
              +   L+K++   +  L   K    +   + ++   + + K  + LS   A EE +   
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
            +E ER                         LEK+    + Q+ E + QL E   EL A +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559

Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
                 +  +   L+ QF  + +  ++Q    +  L+ Q  + E  L +++++ +      
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619

Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
              ++ ++  +EL A    +     +K+L ++Q +  + ++++ +                
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679

Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
                  + DL + Q +++ A R        K E+ +E+ +SL   N    E   L A + 
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
             + E  E  +G +E++ + +     +    E+L+           + E+ R++L  +   
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
            L+++L      + E  +K K   + T+ +L  ++  L E V   + +  A++ SL Q + 
Sbjct: 1797 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 2307 SLTE 2310
             L E
Sbjct: 1850 KLKE 1853



 Score =  160 bits (404), Expect = 2e-38
 Identities = 201/1040 (19%), Positives = 451/1040 (43%), Gaps = 126/1040 (12%)

Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
            D+ + L+ ++   + ++  K  +E ++++L   I   DD    L +E+K LE  + +L  
Sbjct: 954  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
             + + +++   +       ES+++ELE+   LK  E    E+E +++ L           
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
               ++++ E    LA+ E EL     +  + + +  +A + + + E    +L+       
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
                KA++Q R L    ++LE  K + E+ L       ++ A ++ +   L K  ++ T 
Sbjct: 1132 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188

Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
                ++Q++++    A       L+  K ++  L   +  LEK  + +  + + +    +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248

Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
            ++ HKK++L   Q   +Q+K    E  R    +   K  N +  V  +L E   +  +L 
Sbjct: 1249 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
              ++   +QL           ++ Q +L++ ++ K  +   L  L+ E + LQ      D
Sbjct: 1308 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1350

Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            Q   E+E  Q   LE  +   N+Q    ++K         L+     +E +    +  Q 
Sbjct: 1351 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1399

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             +E L+++ E+     D    KL +TK  L    ++  ++  N  +L  N+ K Q++ DQ
Sbjct: 1400 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
            L  ++ ++ +  +  + + + +     +    LA   +    AK++L  T K     + +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
                + D+ +  +  E  ++  ET+ +    QL+ L++E+   E+ KL+L V  + +  +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
             +++ ++ + + E  +  L+ Q H+ E EL D+          K KL+  L  + L A+ 
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
             ++  +E  +    L+  +   +R+L +      E        +K+A S+ AD   L+  
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695

Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
                        L + + AE+  +SL  + AL+ ++ +LE  + + ++E   +++E   +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1752

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
            E ++    +  ++  +  N++  E +  +K  + ++ LER+  E+   +  ++  VK + 
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
            ++++  L   + +L   +E   +     +   +SLK+           ++KL    + + 
Sbjct: 1813 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1859

Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
            DE    E  +E+      R+K      + +Q E   +  ++       L+R++D      
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1908

Query: 2289 TSTSADSASSPSLSQLESSL 2308
             +T ++ A    ++ L+S L
Sbjct: 1909 EATESNEAMGREVNALKSKL 1928



 Score =  134 bits (336), Expect = 1e-30
 Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)

Query: 285  ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
            + EE+++K+    +  + Q K    LKE      Q  EE   L+  L  + EL  +    
Sbjct: 850  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 342  LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
              R   K+ ELE+ L  ++++A+ E                                   
Sbjct: 910  RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 935

Query: 402  SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
                D  Q +Q ++ +  +Q+ +          L+ QLE++E   +K+      A+ ++ 
Sbjct: 936  ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 455  ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
            +L DEI   + Q  + ++E K LEE I     + A ++   K L+   +L NK      +
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1038

Query: 515  LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
            LE++++K+++     ++E++ L+  ++  D+ D                    ++Q   L
Sbjct: 1039 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1074

Query: 575  ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
            ++++ E+  ++AK+ EE++    +L +     N ALKK  +LEG IS LQE L + +   
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 633  TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
             +A+ + R L +E E L    TE+E   D             +E+  L+ AL E      
Sbjct: 1135 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1185

Query: 693  SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
                   +  ++EA+++           +L E+LE+  R         +A L+K +Q L 
Sbjct: 1186 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1229

Query: 753  NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
                        E+EN++L  +L+        ++     L+ Q+++ Q+  +   DG   
Sbjct: 1230 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1274

Query: 806  PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
              E+  +V +L+ +++  TG +N     +  L K +A L  Q     E+L     ++   
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334

Query: 862  QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
              + R+L+EE    Q++L   + E +Q  ER + + +N      + ++Q   + +  L+E
Sbjct: 1335 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 922  NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
              K  + EI+ LT        ++ E   A   +LEK K     +  + V  LD +   + 
Sbjct: 1393 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 978  KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
             L+K     D+L   E  I+            K   ER     EA     KA   AR L 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1493

Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
             A EA+ EL +     K E   L   K  VG   +        L   ME  +T++  L++
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
             L  T              KG FE  L    E+  E RR++  Q ++Y + + D  K+R
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612



 Score =  130 bits (328), Expect = 1e-29
 Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)

Query: 247  LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
            +++ E +   T++RQ+  E   L+E+E+    L E+K +  E+L+++   + E  + + +
Sbjct: 854  MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 306  LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
            L    +E        EA L+++  E+    L  + + + Q+ ++L    +++    Q+L 
Sbjct: 913  LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970

Query: 358  FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
              K+ A+           A+I K  DE         K   +R +       + +  A + 
Sbjct: 971  LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 414  KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
            +K +   +L+N H ++     +  + E+K     EK     +   S+ H++I   + QI 
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079

Query: 469  RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
                +  + EE +Q                LKKI E    +  L + L       NK  +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 511  EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
            +  DL  ++E  K E+              A +++E+  L+ A+D    S + +   M+ 
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199

Query: 556  QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
            + +   ++L    +Q+++ ++ LD+    + KE  ++                  K LE 
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259

Query: 598  QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
            Q+ E   + +  E  + +L   +  LQ  + ++ G   +A+ +  KL  +  +L  +L +
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 656  ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
                +++E  Q   V+     + +E   L+  L E+ E           +N  L  ++  
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 701  LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
            L  + + +EA              L  +  E     ++LEK     Q E   L  +L+ +
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 748  RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
            RQ + N        E+K+++  +L A+ K++     D+ +  + + ++ +     +   L
Sbjct: 1440 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 804  VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
               EE     +EL R  K+   EM ++ S  D +GK++ +L+K  S+    ++ E  + Q
Sbjct: 1493 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1547

Query: 863  VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
            + E  L++E+   ++   +L    +  +   ER L+AR      Q+E + +Q++ ++H  
Sbjct: 1548 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1601

Query: 920  QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
            +  L+           + ++++G L DL+LQ   A + +E  + QLR+L+ + K     L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 961  EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
            EDA+ S++++F   KE +K  K++         +L  A+   K       ++ +E A  L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721

Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
                    E  R   + AQ   +L   +  +E + + +R   Q+ EQ   E+        
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1775

Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
              S   + E   + +ERQ  E+ ++L  +     S  K     +  +IA+L  +V  +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833



 Score =  129 bits (325), Expect = 3e-29
 Identities = 214/961 (22%), Positives = 418/961 (43%), Gaps = 126/961 (13%)

Query: 247  LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
            ++ LE + +   D+      ER  LEE +  L  +L   E+K     +LK+K    + E+
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039

Query: 301  KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
            + + K  +  ++E    K+  E   SD + +   L+ +  EL     K+ E E + A  +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1098

Query: 361  IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
            +D +    N    +  E++    D    +   R  RN    E    D  + ++  K E +
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1156

Query: 420  EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
            + L +        T    +L  K E++++  +  L E    H+ ++++  Q+  +A EE 
Sbjct: 1157 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 475  -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
             +QLE+  + K   +  K  L K+   L+G L+++ + +QE    + ++E Q QE+  K 
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268

Query: 530  ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
               ++   +L   +  L ++    + M  +  GK  +L  D+  ++ Q Q  +  L E  
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328

Query: 583  SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
             +    + +++ LEE+    Q   +E +  K++LE  IS L   L   K          +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388

Query: 635  AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
            A  E +K  + E E L Q+  E     D+LE        +++EL +L   L  Q ++ ++
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 694  LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
            L++ Q     L A E  + ++  + RD    + +E+  K   L +  + AL+A+ E ER 
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 750  ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
               N + KA+  E+      ++   +  L+     L+ Q+++ +  L  + D L   E+ 
Sbjct: 1506 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 810  AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
              R++   + LK G  E ++ +  +   +    LQ+Q  E             LA +  +
Sbjct: 1562 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620

Query: 858  RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
            + E  +++ +LQ + A+        Q  KL    ++F++  E A  +R       +++E 
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680

Query: 908  RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
            + + +E ++  LQE+L + E  +   DL+ +E  E              EK R+ A++ +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 954  LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
            LE  ++LE+ +   +    D+  K  ++A   S++LAT   T  K+            +L
Sbjct: 1741 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797

Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
            +S LH            T+  +  + A+  ++ E+ +R+   A + L + +    EI L 
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857

Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
                R+  EQ++ + EK   G     Q+  ++E+  E  +R      +LQ  LD     N
Sbjct: 1858 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914

Query: 1106 K 1106
            +
Sbjct: 1915 E 1915



 Score =  129 bits (324), Expect = 3e-29
 Identities = 221/1024 (21%), Positives = 443/1024 (43%), Gaps = 145/1024 (14%)

Query: 85   EALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLD 144
            EA IKKL  +D + ++   N  LSK+            K ++  + +L+ NL  + EK  
Sbjct: 977  EAKIKKL--EDEILVMDDQNNKLSKE-----------RKLLEERISDLTTNLAEEEEKAK 1023

Query: 145  KLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNK 204
             L KL+  N   + IS++E       L+K   +  E+E +   L               +
Sbjct: 1024 NLTKLK--NKHESMISELE-----VRLKKEEKSRQELEKLKRKLEGDASDFH------EQ 1070

Query: 205  ISSLQ-DISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
            I+ LQ  I++LK +Q       ++  +  L   +      L+ +  LEG     Q+  ++
Sbjct: 1071 IADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 264  FERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323
             ER +  + E+ +RDL +   E E LK++    L+    Q +L    ++E  + K++ +E
Sbjct: 1130 -ERAARNKAEKQKRDLGE---ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 324  LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD 383
                   + + ++QK  +      +Q E      F +  A  +  N    E    D A  
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLE-----QFKRAKANLDK-NKQTLEKENADLA-G 1238

Query: 384  ESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE 443
            E   +G+++                Q V+ KK +                 L+ Q+++ +
Sbjct: 1239 ELRVLGQAK----------------QEVEHKKKK-----------------LEAQVQELQ 1265

Query: 444  KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE-EAIQLKK----ISEAGKD---LLY 495
             K S  +   +EL+D++ K + ++   T    + E +AI+L K    +S   +D   LL 
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325

Query: 496  KQLSGRLQLVNKLRQ---EALDLELQMEKQKQEIAGKQKEIKDLQIAI-DSLDSKDPKHS 551
            ++   +L +  KLRQ   E   L+ Q++++ +     ++ I  L I + DS        S
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385

Query: 552  HMKAQKSGK---EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL-TEGQIAAN 607
             ++A + GK   +++++ + +QY++  +  D++     +  +E+ DL   L  + Q+ +N
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 608  -EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI- 665
             E  ++  + +++  +        +  +A+ E R+   +  +L + L E  + +++LE  
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 666  ----------VAMDAENMRKELAELES---ALQEQ-HEVNASLQQTQGDLSAYE-AELEA 710
                      +    +++ K + ELE    AL+ Q  E+   L++ + +L A E A+L  
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 711  RLNL--------RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE 762
             +N+        RD +A   + E ++     QL +   + E E++++AL  A  K    +
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625

Query: 763  EKE---QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK 819
             K+   Q +S +  + + ++    L + Q+KDFQ  L    D     +E+ A   E  +K
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELE---DARASRDEIFATAKENEKK 1681

Query: 820  LKLGTGEMNIHSPSDVLG----KSLADLQKQ-FSEILARSKWERDEAQVRERKLQEEMAL 874
             K    ++ +    D+      +  ADL+K+  +E LA S   R+  Q  +R+L+  +A 
Sbjct: 1682 AKSLEADL-MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 875  QQEKLATGQEEFRQACERALEARMNFDK------------RQHEARIQQMENEIHYLQEN 922
             +E+L   Q       +R  +A    ++            +++E+  QQ+E +   L+  
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 923  LKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKA 982
            L  ME   G    + +      E  +AQL E  +++  E   + + +   DK+LK++   
Sbjct: 1801 LHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857

Query: 983  VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
            V    K+A       K+Q +  +  V ++ ++  E  +E++R +    +  R+L  A   
Sbjct: 1858 VEDERKMAEQY----KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913

Query: 1043 IELL 1046
             E +
Sbjct: 1914 NEAM 1917



 Score =  103 bits (258), Expect = 2e-21
 Identities = 139/642 (21%), Positives = 279/642 (43%), Gaps = 134/642 (20%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            S+L+D  + L+ + R++  +    RQ E+E   L   +D+ ++ K++LE  +  L+  + 
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 1386 KRQQQKDFIDGNVESL-----MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL----- 1435
              +++       VE+L       + EIE   + +E+     + +EKT  + + EL     
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434

Query: 1436 ----------------READRLLAEAE------------SELSCTKEKTK-----NAVEK 1462
                            R+ D+LLAE +            +E    +++TK      A+E+
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 1463 FTDAKRSLLQT----ESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI 1518
              +AK  L +T    +++ E+L     +   N+ + ++  R+L+     +E+ K + EE+
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEEL 1551

Query: 1519 LKEINKIVAAK--------------DSDFQCLSKKKEKLTEELQKL--QKDIEMAERNED 1562
              E+     AK              + D Q   ++ E+   +LQ+   + + E+ +  + 
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611

Query: 1563 HHLQVLKE-------SEVLLQAKRA---------ELEKLKSQVTSQQQEM----AVLDRQ 1602
              L    +        ++ LQA  A         +L KL++Q+   Q+E+    A  D  
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671

Query: 1603 LGHKKE---ELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
                KE   +   L+  ++Q + DL  A R  +    EK       + L EEL+      
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-------EELAEELASSLSGR 1724

Query: 1660 NVQISERK---TQLTLIKQEIEKEEENLQVV---LRQMSKHKTELKNIL----------- 1702
            N    E++    ++  +++E+E+E+ N++ +   +R+ ++   +L N L           
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784

Query: 1703 ---DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL-ELENLQQISQQQKGEIEWQK 1758
                 L+ +N EL+    + +  V    K+ +A LE K+ +LE  +Q+ Q+ + +    K
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE--EQVEQEAREKQAATK 1842

Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
             L ++DK+  E +          VE   K  E  +E+ +    ++ Q KR L  AEE S 
Sbjct: 1843 SLKQKDKKLKEILLQ--------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES- 1893

Query: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
                  +++  N RKLQ+ELD+      ++  +++A++ +L+
Sbjct: 1894 ------QRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score =  101 bits (251), Expect = 1e-20
 Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)

Query: 563  QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
            Q+    ++ Q  E  L +   R  K   E+K+LE+   QLTE +    E L+ + E    
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 901

Query: 620  GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
                    +  +A + +      + E E +L  +   +E+E D+ + +  + + M +++ 
Sbjct: 902  --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953

Query: 679  ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
            +LE  L+E+      LQ  +    A   +LE  + + D + N+L +E     E+++ LT 
Sbjct: 954  DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 735  --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
               E+      L K +   ++ + + +   +KE+++ +   KLK  L+ D +   +Q+ D
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 792  FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
             Q  +  +   L + EE     +A   DE+ +K        N       L   ++DLQ+ 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1126

Query: 847  F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
              SE  AR+K E+ +  + E    L+ E+    +  AT Q+E R   E+    L+  ++ 
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1185

Query: 901  DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
            + R HEA++Q+M  +    +  L E L+  +  +   D   Q  ++E   +  +LR L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 957  KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
             K+  + K ++    L+ ++++L+   +  ++ A AEL    D++  L   V  +     
Sbjct: 1246 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1293

Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
              L EAE    KA + A+D+    ++++  Q LL+++  Q      K  V T       E
Sbjct: 1294 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1344

Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
               L + ++ +   +  + R  + L++  SD+K   ++    +  L          I ++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 1134 ADPFKRRGYWY 1144
               ++ +   Y
Sbjct: 1405 TQQYEEKAAAY 1415



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)

Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
            +++ L Q+++Q++ E++ ++  L++ K   ++   E + L+     L++EK  LQE+   
Sbjct: 840  KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
              +  A+ + +        +  +  L ++E  + + +    QL  ++  +   +  +++Q
Sbjct: 899  ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
            L+E+  A   LQ E    +  +   + ++L      + L  E+  L++ IS+        
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1015

Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
              EEE K + L  L+N+    I E +++L ++E   Q L+K +   E          + L
Sbjct: 1016 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
            +     LK Q  + E+EL    ++LD         L K+   E  +  LQE+     +  
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
                + KR L E  + L   +E + +  A Q+E  + R  + ++L+     E +  E QV
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
              +++       +L + L + K+  + + K   T+E   ++N + A  L + L Q + E 
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1250

Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
               KK++  Q         D ER + E++D +  L++EV + +   L        +L  D
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1309

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
            + ++   +  L+   E L+E     +N      +L   +  + D+       ++ L    
Sbjct: 1310 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366

Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
              L  QL     K        E L +GK++ +  + +L +Q +             +   
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426

Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
              L  L   L    QL  N EK
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEK 1448



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 111/510 (21%), Positives = 221/510 (43%), Gaps = 68/510 (13%)

Query: 265  ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
            +R  +  +E+ +R  ++ + E + + SK    R   E + ++K  K+L     L++    
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1496

Query: 323  ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
            E K +L   N++LK +  +L  +     +   EL   K  ++ + E +     E  +  +
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556

Query: 381  APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
            A +++    K R + NM A +       QA   +  E   QL+      R     +T+LE
Sbjct: 1557 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1606

Query: 441  DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
            D+ K+ + A     +L  +++  E   L+A    K  EEAI QL+K+    KD   +   
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663

Query: 500  GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
             R            N+ + ++L+   ++LQ +    E A KQ +++  ++A +   S   
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 549  KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
            +++ ++ +K   E ++  + ++ ++ +  ++ +  R+ K T++ + L  +L   +  A  
Sbjct: 1724 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 607  NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
            NE+ ++ LE     + S L E  G +K                       +A + Q   +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842

Query: 641  KLRDEKETLLQRLTEVEQERDQLEIVAMDAE----NMRKELAELESALQEQHEVNASLQQ 696
             L+ + + L + L +VE ER   E     AE     +++   +LE A +E   +NA+ ++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902

Query: 697  TQGDLSAYEAELEARLNLRDAEANQLKEEL 726
             Q +L       EA       E N LK +L
Sbjct: 1903 LQRELDEATESNEA----MGREVNALKSKL 1928


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  174 bits (441), Expect = 9e-43
 Identities = 223/1064 (20%), Positives = 472/1064 (44%), Gaps = 115/1064 (10%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ + L+ ++     + A KR+ E E  EL  +IDDL      +E E       V+
Sbjct: 917  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
               ++   +D  +  L  E   +K+L+  H+  +D+++  E    TL K + +L ++ D 
Sbjct: 977  NLTEEMAGLDEIIAKLTKE---KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD 1033

Query: 1441 LLA--EAESELSCTKEKTKNAVE---KFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
            L    E E ++    E+ K  +E   K T  + S++  E+D ++L+ R ++    L   +
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLT--QESIMDLENDKQQLDERLKKKDFELNALN 1091

Query: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
             ++   QA    L++   + +  ++E+ + + A+ +    + K +  L+ EL+++ + +E
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151

Query: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQ 1593
             A       +++ K+ E   Q  R +LE+                      L  Q+ + Q
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211

Query: 1594 QEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
            +    L+++    K EL  +  +M   ++AKA+L++  R  E ++ E  +   E +  + 
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271

Query: 1651 ELSFQK-------GELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
            +L+ Q+       GEL+ Q+ E++   +QLT  K    ++ E+L+  L +  K K  L +
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331

Query: 1701 ILDMLQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQK 1751
             L   Q   H+   L+ Q++         QRV     ++VA    K E + +Q+  + ++
Sbjct: 1332 AL---QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1388

Query: 1752 GEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD-------IWEKKLA 1804
             + +  ++L E ++  +E + A+  +L+     L  E EDL    +         +KK  
Sbjct: 1389 AKKKLAQRLQEAEEA-VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447

Query: 1805 QTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKRE 1864
               ++LA  ++  +  QS LE  +   R L  EL         L N      + L+  + 
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL-------FKLKNAYEESLEHLETFKR 1500

Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
               +LQEE++++ + L  + + +    K +  L +E+  LQ  + E          E   
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE---------AEASL 1551

Query: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV-----TLKEQQHQLE 1979
            + ++ ++L+ ++E N++K    E+  +  +K+ E E++K    +V     T  + + +  
Sbjct: 1552 EHEEGKILRAQLEFNQIKA---EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR 1608

Query: 1980 KELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
             E    K K++  L+++ +      R   E ++  +SL+  L  T+ QL +  +   +  
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668

Query: 2039 GELLALQKEADSMRADFSLLR---NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQK 2095
              +  +++  + ++A+   LR    Q    RK AE+++    E +++  SQ    + ++K
Sbjct: 1669 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK 1728

Query: 2096 QENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISD 2155
            + ++ + +    +E   Q+      +  K +        ELKK+      LER +  +  
Sbjct: 1729 KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788

Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGP 2215
             ++ L+  + +  + +LK   + L +L A       R   LE ELE+ ++    ++ +G 
Sbjct: 1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEA-------RVRELENELEAEQKRNAESV-KGM 1840

Query: 2216 FEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 2275
             + +    ++    E  R   LR  L+   D+L+ +++    +QAE   + + Q    L 
Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLR--LQDLVDKLQLKVK-AYKRQAE---EAEEQANTNLS 1894

Query: 2276 SLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQE 2319
              R+    L E      AD A S  +++L +   +    G N+E
Sbjct: 1895 KFRKVQHELDE--AEERADIAES-QVNKLRAKSRDIGTKGLNEE 1935



 Score =  152 bits (384), Expect = 4e-36
 Identities = 225/1034 (21%), Positives = 451/1034 (43%), Gaps = 140/1034 (13%)

Query: 1398 VESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKRRSELREADRLLAEAESELSCTKEKT 1456
            ++ L+   E EK +   ++    + E +EK+   RR EL E    L + +++L    +  
Sbjct: 836  IKPLLKSAEREKEMASMKEEFTRLKEALEKSEA-RRKELEEKMVSLLQEKNDLQLQVQAE 894

Query: 1457 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
            +   +   DA+    Q   +  +LE + +E    L   ++    L A  + LE    + +
Sbjct: 895  Q---DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951

Query: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESE 1572
              + ++   +A  + +      K + LTEE+  L + I    +     ++ H Q L +  
Sbjct: 952  RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD-- 1009

Query: 1573 VLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
              LQA+  ++  L       +Q++  L+  L  +K+    ++  + +AK  L+  L+L +
Sbjct: 1010 --LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK----VRMDLERAKRKLEGDLKLTQ 1063

Query: 1633 TEVTEKCNHIREVKSLLEELSFQKGELNVQI-------SERKTQLTLIKQEIEKEEENLQ 1685
              + +  N  +++   L++  F+   LN +I       S+ + +L  ++  IE+ EE L+
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123

Query: 1686 V-------VLRQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSEL 1726
                    V +  S    EL+ I + L         Q+E     E +  K++ D   + L
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183

Query: 1727 EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS 1786
            +    A    K   +++ ++  +Q   ++  KQ LE++K E +    E   + S +E + 
Sbjct: 1184 QHEATAAALRKKHADSVAELG-EQIDNLQRVKQKLEKEKSEFK---LELDDVTSNMEQII 1239

Query: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD------- 1839
            K K +L++ C   E ++ + +      + +     S   KL+    +L ++LD       
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299

Query: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
            QL R KL+    +  +++QL+E+ +A N+L   L + +   +L ++     T+ +  L  
Sbjct: 1300 QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR 1359

Query: 1900 EQTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQ 1951
              ++   ++++W  ++E    Q+ EE ++      Q+LQ  +  +E    K    E    
Sbjct: 1360 VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419

Query: 1952 RLQKERESEESKLETSK---VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE 2008
            RLQ E E     +E S      L ++Q   +K L + K K ++  S++ ++++  R+L  
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479

Query: 2009 E-----ERWCESLE--KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
            E       + ESLE  +T  +  + L E    L E+ G       E + +R      + +
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME 1539

Query: 2062 FLTERKKAEKQVASLK-EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA- 2119
              +  ++AE   ASL+ E  KI R+QLE N ++ + E    +K+    +  A+ NH R  
Sbjct: 1540 LQSALEEAE---ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ--AKRNHLRVV 1594

Query: 2120 ---------------------RRLMKELNQMQYEYT-------ELKKQMAN-QKDLERRQ 2150
                                 +++  +LN+M+ + +       E +KQ+ + Q  L+  Q
Sbjct: 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654

Query: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE- 2205
            +++ DA+R    ++K+ I    +  N    EL  +L A++E+ E      E EL    E 
Sbjct: 1655 IQLDDAVRA-NDDLKENIAIVERRNNLLQAEL-EELRAVVEQTERSRKLAEQELIETSER 1712

Query: 2206 -NLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRH 2254
              L  + N     +K     + SQ+    E    EA++E  R+ E++ K      A +  
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVE----EAVQE-CRNAEEKAKKAITDAAMMAE 1767

Query: 2255 CMSKQAEV---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE- 2310
             + K+ +    L + K+  E T+  L+ ++D   ++     A       L +LE+ + E 
Sbjct: 1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI-----ALKGGKKQLQKLEARVREL 1822

Query: 2311 DSQLGQNQEKNASA 2324
            +++L   Q++NA +
Sbjct: 1823 ENELEAEQKRNAES 1836



 Score =  124 bits (311), Expect = 1e-27
 Identities = 180/802 (22%), Positives = 350/802 (43%), Gaps = 93/802 (11%)

Query: 1542 KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
            K+   L+  +++ EMA   E+     LKE+    +A+R ELE+   ++ S  QE   L  
Sbjct: 835  KIKPLLKSAEREKEMASMKEE--FTRLKEALEKSEARRKELEE---KMVSLLQEKNDLQL 889

Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNV 1661
            Q+  +++ L   +    Q    ++  ++L E +V E    + + + +  EL+ +K +L  
Sbjct: 890  QVQAEQDNLADAEERCDQL---IKNKIQL-EAKVKEMNERLEDEEEMNAELTAKKRKLED 945

Query: 1662 QISERKTQ---LTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQ 1718
            + SE K     L L   ++EKE+   +  ++ +++    L  I+  L  E   LQ     
Sbjct: 946  ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA--- 1002

Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQL---LERDKREIERMTAES 1775
            H Q + +L+  +  V         L+Q     +G +E +K++   LER KR++E    + 
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE---GDL 1059

Query: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME---QSNLEKLELNVR 1832
            +  Q  +  L  +K+ L E+    +KK  +   + A  E+   +    Q  L++L+  + 
Sbjct: 1060 KLTQESIMDLENDKQQLDERL---KKKDFELNALNARIEDEQALGSQLQKKLKELQARIE 1116

Query: 1833 KLQQEL--DQLNRDKL-SLHNDISAMQQQLQEKRE---AVNSLQEELANVQD-HLNLAKQ 1885
            +L++EL  ++  R K+  L +D+S   +++ E+ E      S+Q E+   ++      ++
Sbjct: 1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1176

Query: 1886 DLLHTT-KHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLV 1944
            DL   T +H+    + + +    ++E   + ++ Q+ +       Q L+ E  E KL+L 
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK-------QKLEKEKSEFKLELD 1229

Query: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK------ELTDQKSKLDQVLSKVLA 1998
                  +++ K + + E    T +  + E + + E+      +LT Q++KL         
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ------TE 1283

Query: 1999 AEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLL 2058
              E  R L E+E     L +      +QL + ++QL E+     AL     S R D  LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343

Query: 2059 RNQFLTERK-KAEKQVASLKEALKIQ--RSQLEKNLLEQKQENSCIQKEMA----TIELV 2111
            R Q+  E + KAE Q    K   ++   R++ E + +++ +E    +K++A      E  
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403

Query: 2112 AQDNHERARRLMKELNQMQYEYTEL---------------KKQMANQKDLERRQMEISDA 2156
             +  + +   L K  +++Q E  +L               KKQ    K L   + +  ++
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463

Query: 2157 MRTLKSEVKD--EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT---- 2210
               L+S  K+   + T L  L     E    LE     N+NL+ E+  L E L  +    
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523

Query: 2211 ---------MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAE 2261
                     +     E +    +     EH  G+ LR +L    +++KA++   ++++ E
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF--NQIKAEIERKLAEKDE 1581

Query: 2262 VLIKGKRQTEGTLHSLRRQVDA 2283
             + + KR     + SL+  +DA
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDA 1603



 Score =  113 bits (282), Expect = 2e-24
 Identities = 196/954 (20%), Positives = 396/954 (41%), Gaps = 147/954 (15%)

Query: 271  EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNT 330
            +++ LE  L K   E    ++K     EE+   D++   L +E    +++ ++   DL  
Sbjct: 953  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012

Query: 331  KNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK 390
            + +    K   LT+A   + +LEQ+     +D     L        ++++A        K
Sbjct: 1013 EED----KVNTLTKA---KVKLEQQ-----VDDLEGSLEQEKKVRMDLERA--------K 1052

Query: 391  SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
             + + ++  T+  I+D    ++  K + DE+L+     L     L+ ++ED++   S  Q
Sbjct: 1053 RKLEGDLKLTQESIMD----LENDKQQLDERLKKKDFELNA---LNARIEDEQALGSQLQ 1105

Query: 451  TRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQ 510
             +L EL   IE              +LEE ++ ++ + A  + L   LS  L+ +++  +
Sbjct: 1106 KKLKELQARIE--------------ELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151

Query: 511  EALD-LELQMEKQKQEIAGKQKEIKDLQIA---------------IDSLDSKDPKHSHMK 554
            EA     +Q+E  K+  A  QK  +DL+ A                DS+     +  +++
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211

Query: 555  AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALK--K 612
              K   E++      +   + S +++I+   A   +  + LE+Q+ E +  A E  +   
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271

Query: 613  DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA-- 670
            DL    + LQ   G +  Q  + +    +L   K T  Q+L +++++ ++ E+ A +A  
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE-EVKAKNALA 1330

Query: 671  ---ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE 727
               ++ R +   L    +E+ E  A LQ+    LS   +E+       + +A Q  EELE
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSEVAQWRTKYETDAIQRTEELE 1387

Query: 728  KV-TRLTQLEQSALQA---------ELEKERQALKN-----------------ALGK--- 757
            +   +L Q  Q A +A          LEK +  L+N                 AL K   
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447

Query: 758  ------AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA 811
                  A++ ++ E+  SEL +  K  +  +  L +    ++  L H+       + +  
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1507

Query: 812  RVDELRRKLKLGTGEMNIHSPSDV---LGKSLADLQKQFSEILARSKWERDEAQVRERKL 868
             + +L    +LG+    IH    V   L     +LQ    E  A +  E +E ++   +L
Sbjct: 1508 EISDLTE--QLGSSGKTIHELEKVRKQLEAEKMELQSALEE--AEASLEHEEGKILRAQL 1563

Query: 869  Q--EEMALQQEKLATGQEEFRQACERAL------------EARMNFD----KRQHEARIQ 910
            +  +  A  + KLA   EE  QA    L            E R   +    K++ E  + 
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623

Query: 911  QMENEIHY-------LQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDA 963
            +ME ++ +        Q+ +KS++ +   T +QL +A    + +   +  +E++  L  A
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683

Query: 964  KSQE--QVFGLDKELKKL--KKAVATSDK--LATAELTIAKDQLKSLHGTVMKINQERAE 1017
            + +E   V    +  +KL  ++ + TS++  L  ++ T   +Q K +   + ++  E  E
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEE 1743

Query: 1018 ELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG---ANSQV 1074
             +QE      KA +A  D      E++  Q+      E+ +  ME+T          ++ 
Sbjct: 1744 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNMEQTIKDLQHRLDEAEQ 1802

Query: 1075 LEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQND 1128
            + ++   + +++    +  L+N L+     N    + + +    + +E++YQ +
Sbjct: 1803 IALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTE 1855



 Score =  112 bits (281), Expect = 3e-24
 Identities = 185/874 (21%), Positives = 372/874 (42%), Gaps = 122/874 (13%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
            EE  RL+  LEK     +EL+ K    L+E KN  +L    +++ +   ++ C++L    
Sbjct: 854  EEFTRLKEALEKSEARRKELEEKMVSLLQE-KNDLQLQVQAEQDNLADAEERCDQL---- 908

Query: 329  NTKNEL-LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
              KN++ L+ K  E+    + + E+  EL   K   K E       E +E+ +  D+   
Sbjct: 909  -IKNKIQLEAKVKEMNERLEDEEEMNAELTAKK--RKLE------DECSELKRDIDDLE- 958

Query: 388  IGKSRYKRNMFATESYIIDSAQAVQ-----IKKMEPDEQ-LRNDHMNLRGHTPLDTQLED 441
            +  ++ ++   ATE+ + +  + +      I K+  +++ L+  H         +   ED
Sbjct: 959  LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE---ED 1015

Query: 442  KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLS 499
            K   ++ A+ +L +  D++E + +Q  +   + ++ +  ++  LK   E+  DL     +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL----EN 1071

Query: 500  GRLQLVNKLRQEALDLE-LQMEKQKQEIAGK--QKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
             + QL  +L+++  +L  L    + ++  G   QK++K+LQ  I+ L+ +      ++A+
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEE------LEAE 1125

Query: 557  KSGK---EQQLDIMNKQYQQLESRLDEI-----------LSRIAKETEEIKDLEEQLTEG 602
            ++ +   E+    ++++ +++  RL+E              R A+  +  +DLEE   + 
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185

Query: 603  QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
            +  A    KK  + V          +  Q    Q   +KL  EK      L +V    +Q
Sbjct: 1186 EATAAALRKKHADSV--------AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1237

Query: 663  LEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA-------ELEARLNLR 715
               +     N+ K    LE  + E        Q++  DL++  A       EL  +L+ +
Sbjct: 1238 ---IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294

Query: 716  DAEANQLKEELEKVTRLTQLEQSALQAELE-KERQALKNALGKAQFS----EEKEQENSE 770
            +A  +QL     K+T   QLE    Q E E K + AL +AL  A+       E+ +E +E
Sbjct: 1295 EALISQLTR--GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352

Query: 771  LHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN-I 829
              A+L+ +     L K   +  Q    +  D + R EE+     +L ++L+     +  +
Sbjct: 1353 AKAELQRV-----LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407

Query: 830  HSPSDVLGKSLADLQKQFSEILA---RSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
            ++    L K+   LQ +  +++    RS         ++R   + +A  ++K    Q E 
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467

Query: 887  R--QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944
               Q   R+L   +   K  +E  ++ +E    + +EN    EEI  LT+ QL  + +  
Sbjct: 1468 ESSQKEARSLSTELFKLKNAYEESLEHLET---FKRENKNLQEEISDLTE-QLGSSGK-- 1521

Query: 945  ERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004
                  + ELEK +K  +A+  E    L++    L+       K+  A+L     +   +
Sbjct: 1522 -----TIHELEKVRKQLEAEKMELQSALEEAEASLEH---EEGKILRAQL-----EFNQI 1568

Query: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064
               + +   E+ EE+++A+R   +   + +    AE          R + E  R++ +  
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET---------RSRNEALRVKKKME 1619

Query: 1065 GVGTGANSQVLEIEKLNETMERQRTEIARLQNVL 1098
            G     N   +++   N      + ++  LQ++L
Sbjct: 1620 G---DLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650



 Score =  110 bits (276), Expect = 1e-23
 Identities = 151/726 (20%), Positives = 316/726 (43%), Gaps = 70/726 (9%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
            NLE     LED M   +SK                  EE   +++DL  ++  L+ E  E
Sbjct: 1244 NLEKMCRTLEDQMNEHRSK-----------------AEETQRSVNDLTSQRAKLQTENGE 1286

Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHH-EDIVDEIECIEKTLLKRRSE---L 1435
            L R + +++     I       +T  +  + LK   E+ V     +   L   R +   L
Sbjct: 1287 LSRQLDEKEA---LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTES--DAEELERRAQETAVNLVK 1493
            RE      EA++EL     K  + V ++    R+  +T++    EELE   ++ A  L +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQW----RTKYETDAIQRTEELEEAKKKLAQRLQE 1399

Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
            A++ + ++ A    LE+ K + +  ++++   V   ++    L KK+    + L + ++ 
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459

Query: 1554 IEMAERN-EDHHLQVLKESEVLLQAKRA------ELEKLKSQVTSQQQEMAVLDRQLGHK 1606
             E ++   E    +    S  L + K A       LE  K +  + Q+E++ L  QLG  
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSS 1519

Query: 1607 KEELHLLQGSMVQAKA---DLQEALRLGETEVTEKCNHIREVKSLLEELSFQ--KGELNV 1661
             + +H L+    Q +A   +LQ AL   E  +  +     E K L  +L F   K E+  
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE-----EGKILRAQLEFNQIKAEIER 1574

Query: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQ 1721
            +++E+  ++   K+   +  ++LQ  L   ++ + E   +   ++ + +E++ ++L H  
Sbjct: 1575 KLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME-IQLSHAN 1633

Query: 1722 RVSELEKTQVAVLEEKLELENLQ-QISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            R++   + QV  L+  L+   +Q   + +   +++    ++ER    ++    E RA+  
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
              E   K  E  QE  +  E+      +  +   +  KM+ ++L +L+  V +  QE   
Sbjct: 1694 QTERSRKLAE--QELIETSERVQLLHSQNTSLINQKKKMD-ADLSQLQTEVEEAVQECRN 1750

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREA-------VNSLQEELANVQDHLNLAKQDLLHTTKH 1893
                      D + M ++L+++++          ++++ + ++Q  L+ A+Q  L   K 
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810

Query: 1894 QDVLLSEQTR-LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR 1952
            Q   L  + R L+ ++     R  +  K     +++++ L  + EE++  L++ + +  +
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870

Query: 1953 LQ-------KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005
            LQ       ++ E  E +  T+    ++ QH+L+ E  ++    +  ++K+ A    + T
Sbjct: 1871 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD-EAEERADIAESQVNKLRAKSRDIGT 1929

Query: 2006 --LQEE 2009
              L EE
Sbjct: 1930 KGLNEE 1935



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 125/608 (20%), Positives = 258/608 (42%), Gaps = 100/608 (16%)

Query: 564  LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGL 621
            + + N  + +L  ++  +L    +E +E+  ++E+ T  +  +  +EA +K+LE  +  L
Sbjct: 822  MGVKNWPWMKLYFKIKPLLKSAERE-KEMASMKEEFTRLKEALEKSEARRKELEEKMVSL 880

Query: 622  QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
             +    ++ Q    Q+      +  + L++   ++E +  ++     D E M  EL   +
Sbjct: 881  LQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940

Query: 682  SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ 741
              L+++    + L++   DL    A++E   +  + +   L EE+  +  +         
Sbjct: 941  RKLEDEC---SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII-------- 989

Query: 742  AELEKERQALKNALGKA--QFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
            A+L KE++AL+ A  +A      E+++ N+   AK+K        L+QQ+ D +  L   
Sbjct: 990  AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK--------LEQQVDDLEGSLE-- 1039

Query: 800  VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
                   +E   R+D  R K KL  G++ +        +S+ DL             E D
Sbjct: 1040 -------QEKKVRMDLERAKRKL-EGDLKLTQ------ESIMDL-------------END 1072

Query: 860  EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI--- 916
            + Q+ ER  +++  L            R   E+AL +++    ++ +ARI+++E E+   
Sbjct: 1073 KQQLDERLKKKDFELNALNA-------RIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125

Query: 917  ---------------HYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK----- 956
                             L+E  + +EE  G T +Q++   + +       R+LE+     
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185

Query: 957  -------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGT 1007
                   +KK  D+ ++  EQ+  L +  +KL+K   +  KL   ++T   +Q+      
Sbjct: 1186 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDVTSNMEQIIKAKAN 1244

Query: 1008 VMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQ-NLLRQKGEQFRLEMEKTGV 1066
            + K+ +   +++ E    + +  ++  DLT   A+++     L RQ  E+  L  + T  
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT-- 1302

Query: 1067 GTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFENVLEEIAELRREV 1123
              G  +   ++E L   +E +      L + L     D    +  +E   E  AEL+R +
Sbjct: 1303 -RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361

Query: 1124 SYQNDYIS 1131
            S  N  ++
Sbjct: 1362 SKANSEVA 1369



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 152/745 (20%), Positives = 314/745 (42%), Gaps = 93/745 (12%)

Query: 126  KLEVLNLSYNLIGKIE---KLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIE 182
            KLE+ +++ N+   I+    L+K+ +  E  ++ ++ SK E  +   N      A  + E
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTE 1283

Query: 183  HIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIF 242
            +  +      K   +  L   K++  Q +  LK  + L   +  +N    L H LQ    
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLK--RQLEEEVKAKN---ALAHALQSARH 1338

Query: 243  HLRSL-ESLEGQPVTTQDRQEAFERFSLEEVE---RLERDLEKKMIETEELKSKQTRFLE 298
                L E  E +     + Q    + + E  +   + E D  ++  E EE K K  + L+
Sbjct: 1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398

Query: 299  EIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAF 358
            E +          E    +  S E+ K  L  + E L    +E + A     + +Q   F
Sbjct: 1399 EAEEA-------VEAVNAKCSSLEKTKHRLQNEIEDL-MVDVERSNAAAAALDKKQR-NF 1449

Query: 359  YKIDAKFEPLNYYPSEYAEIDKAPDESPYIG------KSRYKRNMFATESYIIDSAQAVQ 412
             KI A+++    Y    +E++ +  E+  +       K+ Y+ ++   E++  ++   +Q
Sbjct: 1450 DKILAEWK--QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN-LQ 1506

Query: 413  IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE 472
             +  +  EQL +    +     +  QLE ++ ++ +A   L E    +E  E +ILRA  
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA---LEEAEASLEHEEGKILRAQL 1563

Query: 473  EFKQLEEAIQLKKISEAGKDL---------LYKQLSGRLQLVNKLRQEAL---------- 513
            EF Q++  I+ +K++E  +++         +   L   L    + R EAL          
Sbjct: 1564 EFNQIKAEIE-RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622

Query: 514  -DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQ 572
             ++E+Q+    +  A  QK++K LQ  +   D++      ++A    KE  + I+ ++  
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLK--DTQIQLDDAVRANDDLKEN-IAIVERRNN 1679

Query: 573  QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 632
             L++ L+E L  + ++TE  + L EQ                   +    E +  +  Q 
Sbjct: 1680 LLQAELEE-LRAVVEQTERSRKLAEQ------------------ELIETSERVQLLHSQN 1720

Query: 633  TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
            T   N+ +K+  +   L Q  TEVE+   +       A+    + A +   L+++ + +A
Sbjct: 1721 TSLINQKKKMDAD---LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA 1777

Query: 693  SLQQTQGDLSAYEAELEARLNLRDAEANQL-----KEELEKVTRLTQLEQSALQAELEKE 747
             L++ + ++     +L+ RL+    EA Q+     K++L+K+    +  ++ L+AE ++ 
Sbjct: 1778 HLERMKKNMEQTIKDLQHRLD----EAEQIALKGGKKQLQKLEARVRELENELEAEQKRN 1833

Query: 748  RQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD----GL 803
             +++K      +  +E   +  E    L  LQD  + L+ ++K ++       +     L
Sbjct: 1834 AESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1893

Query: 804  VRPEEVAARVDELRRKLKLGTGEMN 828
             +  +V   +DE   +  +   ++N
Sbjct: 1894 SKFRKVQHELDEAEERADIAESQVN 1918



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 121/516 (23%), Positives = 225/516 (43%), Gaps = 88/516 (17%)

Query: 268  SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
            S  E+E  +++      E  +LK+     LE ++   + NK+L+EE        E+L S 
Sbjct: 1463 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI---SDLTEQLGSS 1519

Query: 328  LNTKNEL------LKQKTIELTRACQK-----QYE----LEQELAFYKIDAKFEPLNYYP 372
              T +EL      L+ + +EL  A ++     ++E    L  +L F +I A+ E      
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE------ 1573

Query: 373  SEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH 432
             + AE D+  +++        KRN       ++DS Q         D + R+ +  LR  
Sbjct: 1574 RKLAEKDEEMEQA--------KRNHLR----VVDSLQT------SLDAETRSRNEALRVK 1615

Query: 433  TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ----LKK--- 485
              ++  L + E ++S A    +E   ++ K+ Q +L+ T+   QL++A++    LK+   
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQV-KSLQSLLKDTQ--IQLDDAVRANDDLKENIA 1672

Query: 486  ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS 545
            I E   +LL  +L        +LR      E   +  +QE+    + ++ L     SL +
Sbjct: 1673 IVERRNNLLQAEL-------EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1725

Query: 546  KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIA 605
            +  K   M A  S  + +++   ++ +  E +  + ++  A   EE+K  +EQ T   + 
Sbjct: 1726 QKKK---MDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK--KEQDTSAHL- 1779

Query: 606  ANEALKKDLEGVISGLQEYLG-----TIKGQATQAQN---ECRKLRDEKETLLQRLTE-- 655
              E +KK++E  I  LQ  L       +KG   Q Q      R+L +E E   +R  E  
Sbjct: 1780 --ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837

Query: 656  --VEQERDQLEIVAMDAENMRKELAELESALQE-QHEVNASLQQTQGDLSAYEAELEARL 712
              + +   +++ +    E  RK L  L+  + + Q +V A  +Q      A EAE +A  
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ------AEEAEEQANT 1891

Query: 713  NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER 748
            NL  ++  +++ EL++      + +S +     K R
Sbjct: 1892 NL--SKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  173 bits (439), Expect = 2e-42
 Identities = 222/1020 (21%), Positives = 447/1020 (43%), Gaps = 135/1020 (13%)

Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS 1410
            ++EKEM  +  + +   +E    E   +EL   +    Q+K+ +         +L+++  
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDL---------QLQVQSE 898

Query: 1411 LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
             ++  D  +  E + K+ +   ++++E    L E E   S    K +N  +K +  KR +
Sbjct: 899  TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958

Query: 1471 LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
               E    ++E+    T   +    +++ +L+ +   L + K   +E  ++    +  ++
Sbjct: 959  DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018

Query: 1531 SDFQCLSK---KKEKLTEELQ-------KLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
                 L K   K E+ T++L+       KL+ D+E A+R  +  L++ +ES + L+  + 
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078

Query: 1581 EL-EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC 1639
            ++ EKLK +     Q  A +D       E++H LQ                 + ++ E  
Sbjct: 1079 QIEEKLKKKEFELSQLQAKID------DEQVHSLQ----------------FQKKIKELQ 1116

Query: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
              I E++  +E     + ++  Q S+   +L  I + +E+        +    K + E +
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176

Query: 1700 NILDMLQLENHELQGLKLQHDQRVSELEKTQV-AVLEEKLELENLQQISQQQKGEIEWQK 1758
             +     LE   LQ     H+   + L K Q  +V E   +++NLQ++           K
Sbjct: 1177 KM--RRDLEEATLQ-----HEATAATLRKKQADSVAELGEQIDNLQRV-----------K 1218

Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKC--------DIWEKKLAQTKRVL 1810
            Q LE++K E++    E   + S +E LSK K +++  C        +I  K   QT+ + 
Sbjct: 1219 QKLEKEKSELK---MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275

Query: 1811 AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQ 1870
                + ++++  N E L   V + +  + QL + K +L   +  +++Q++E+ +A N++ 
Sbjct: 1276 DLNMQKARLQTQNGE-LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334

Query: 1871 EELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED--CQKEEETKQ-- 1926
              L + +   +L ++      + +  L    ++   ++++W  ++E    Q+ EE ++  
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 1927 ----QQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE---TSKVTLKEQQHQLE 1979
                Q+LQ  +   E    K    E   QRLQ E E     LE   T+  TL ++Q   +
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFD 1454

Query: 1980 KELTDQKSKLDQVLSKVLAAEERVRTLQEE--------ERWCESLEKTLSQTKRQLSERE 2031
            K L + K KLD+  +++ AA++  R+L  E        E   + LE TL +  + L E  
Sbjct: 1455 KVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLE-TLRRENKNLQEEI 1513

Query: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA------SLK-EALKIQR 2084
              L E+  E     +EA+         + + L E++K++ QVA      SL+ E  KI R
Sbjct: 1514 SDLTEQIAETGKNLQEAE---------KTKKLVEQEKSDLQVALEEVEGSLEHEESKILR 1564

Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELN---QMQYEYTELKKQM- 2140
             QLE + ++ + +   I+K+   IE + +++   A  L   L+   + + +   LKK+M 
Sbjct: 1565 VQLELSQVKSELDRKVIEKD-EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623

Query: 2141 --ANQKDLE-----RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERN 2193
               N+ +++     R+  E    +RT++ ++KD  +  L +  +   +L   L  +  RN
Sbjct: 1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS-QLHLDDALRSNEDLKEQLAIVERRN 1682

Query: 2194 ENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK---LRHREDRLKA 2250
              L  ELE +K  L  T      E     S+  ++D   R + L  +   L + + +L+A
Sbjct: 1683 GLLLEELEEMKVALEQT------ERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEA 1736

Query: 2251 QLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE 2310
             +  C + + E  I+  R  E      ++ +     +      +  +S  L +++ +L +
Sbjct: 1737 DIAQCQA-EVENSIQESRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792



 Score =  167 bits (423), Expect = 1e-40
 Identities = 220/1057 (20%), Positives = 460/1057 (43%), Gaps = 147/1057 (13%)

Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQ-------KDFIDGNVESLMT 1403
            +SE   +EL   +  LLQEK  L+ +V+     +   +++       K  ++  V+ L  
Sbjct: 869  RSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTE 928

Query: 1404 ELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKF 1463
             LE E+ +  + ++V +   +E      + ++ + +  L + E E   T+ K KN  E+ 
Sbjct: 929  RLEEEEEM--NSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEM 986

Query: 1464 TDAKRSLLQTESDAEELERRAQETAVNL--------------VKADQQLRSLQADAK--- 1506
            T  + ++ +   + + L+   Q+T  +L               K +QQ   L+   +   
Sbjct: 987  TALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK 1046

Query: 1507 ----DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
                DLE+ K K E  LK   + +   ++D Q + +K +K   EL +LQ  I+     + 
Sbjct: 1047 KLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID---DEQV 1103

Query: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
            H LQ  K+ + L    +A +E+L+ ++ ++    A +++Q      EL  +   + +A  
Sbjct: 1104 HSLQFQKKIKEL----QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASG 1159

Query: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQ-----------KGELNVQISERKTQLT 1671
                 + + +    E     ++++  LEE + Q           + +   ++ E+   L 
Sbjct: 1160 ATSAQIEMNKKREAE----FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215

Query: 1672 LIKQEIEKEEENLQVVLRQM-------SKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
             +KQ++EKE+  L++ +  M       SK K+ ++     ++ +  E++    Q  Q + 
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275

Query: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER-MTAESRALQSCVE 1783
            +L   +  +  +  EL +  +  +    ++   KQ L +   E++R M  E++A  +   
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335

Query: 1784 CLSKEKED---LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             L   + D   L+E+ +  ++  A+ +R L+ A  NS++ Q    K E +  +  +EL++
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRALSKA--NSEVAQWRT-KYETDAIQRTEELEE 1392

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV---- 1896
              +        ++   Q+ +E  E  NS    L   +  L    +DL+   +        
Sbjct: 1393 AKKK-------LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445

Query: 1897 LLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
            L  +Q    K ++EW  + ++ Q E E  Q++ + L  E+   K++   +E++ Q     
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL--FKMRNAYEEVVDQLETLR 1503

Query: 1957 RESEESKLETSKVTLKEQQHQLEKELTD---QKSKLDQVLSKVLAAEERVR-TLQEEERW 2012
            RE++  + E S +T  EQ  +  K L +    K  ++Q  S +  A E V  +L+ EE  
Sbjct: 1504 RENKNLQEEISDLT--EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561

Query: 2013 CESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSL---------LRNQFL 2063
               ++  LSQ K   SE +++++EK  E+  L++  +S RA  +L          RN  L
Sbjct: 1562 ILRVQLELSQVK---SELDRKVIEKDEEIEQLKR--NSQRAAEALQSVLDAEIRSRNDAL 1616

Query: 2064 TERKKAE--------------KQVASLKEALKIQRSQLEKNLL---EQKQENSCIQKEMA 2106
              +KK E              +Q+A  ++ L+  + QL+ + L   +  + N  +++++A
Sbjct: 1617 RLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676

Query: 2107 TIELVAQDNHERARRLMKELNQMQ--YEYTELKKQMANQKDLERRQMEISDAMRTLKSEV 2164
             +E        R   L++EL +M+   E TE  ++++     E+  ++ SD ++ L S+ 
Sbjct: 1677 IVE-------RRNGLLLEELEEMKVALEQTERTRRLS-----EQELLDASDRVQLLHSQN 1724

Query: 2165 KDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQ 2224
               I T  K L   + +  A++E  ++ + N E   E  K+ +          +K   + 
Sbjct: 1725 TSLINTK-KKLEADIAQCQAEVENSIQESRNAE---EKAKKAITDAAMMAEELKKEQDTS 1780

Query: 2225 VHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDAL 2284
             H+           E+++   ++    L+H + +  ++ +KG ++    L +  R+++  
Sbjct: 1781 AHL-----------ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE-- 1827

Query: 2285 GELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
             EL       + +     + E  + E +   +   KN
Sbjct: 1828 NELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKN 1864



 Score =  115 bits (288), Expect = 5e-25
 Identities = 187/969 (19%), Positives = 409/969 (42%), Gaps = 110/969 (11%)

Query: 244  LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMI---------------ETEE 288
            L+S E+ +      +D +   E  +  E  R  ++LE+KM+               ETE 
Sbjct: 844  LKSAEAEKEMATMKEDFERTKEELARSEARR--KELEEKMVSLLQEKNDLQLQVQSETEN 901

Query: 289  LKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQK 348
            L   + R    IK++  L   +KE     ++  EE+ S+L  K   L+ K   L R    
Sbjct: 902  LMDAEERCEGLIKSKILLEAKVKELTERLEEE-EEMNSELVAKKRNLEDKCSSLKRDID- 959

Query: 349  QYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK-SRYKRNMFATESYIIDS 407
                + EL   K++ +           +E   A +E+  I K ++ K+++       +D 
Sbjct: 960  ----DLELTLTKVEKEKHATENKVKNLSEEMTALEEN--ISKLTKEKKSLQEAHQQTLDD 1013

Query: 408  AQAVQIK-----KMEPDEQLRNDHM--NLRGHTPLDTQLEDKEKKISA----AQTRLSEL 456
             Q  + K     K+    + + D +  +L     L   LE  ++K+      +Q  + +L
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDL 1073

Query: 457  HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLE 516
             ++ ++ E+++ +   E  QL+  I  +++         K+L  R++ + +  +    L 
Sbjct: 1074 ENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133

Query: 517  LQMEKQKQEIAGKQKEIKD-LQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLE 575
             ++EKQ+ ++A + +EI + L+ A  +  ++   +   +A+     + L+    Q++   
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193

Query: 576  SRLDEILSRIAKETEEIKDLEEQLTEGQIAAN--EALKKDLEGVISGLQEYLGTIKGQAT 633
            + L +      K+ + + +L EQ+   Q      E  K +L+  I  +   +  +    +
Sbjct: 1194 ATLRK------KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247

Query: 634  QAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
              +  CR + D+   +     + EQ+   +  + M    ++ +  EL   ++E+  + + 
Sbjct: 1248 NIERTCRTVEDQFSEI---KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ 1304

Query: 694  LQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQA--- 750
            L +++  L+    EL+ ++     E  + K  +    + ++ +   L+ + E+E++A   
Sbjct: 1305 LTKSKQALTQQLEELKRQME----EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360

Query: 751  LKNALGKA--QFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEE 808
            L+ AL KA  + ++ + +  ++   + + L++    L Q+L++ + +           E+
Sbjct: 1361 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420

Query: 809  VAAR----VDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
               R    V++L R L+        H+    L K     Q+ F ++LA  K + DE+Q  
Sbjct: 1421 TKQRLQGEVEDLMRDLE------RSHTACATLDKK----QRNFDKVLAEWKQKLDESQAE 1470

Query: 865  ERKLQEEMALQQEKLATGQEEFRQACERALE--ARMNFDKRQHEARIQQMENEIHYLQEN 922
                Q+E       L+T   + R A E  ++    +  + +  +  I  +  +I    +N
Sbjct: 1471 LEAAQKE----SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKN 1526

Query: 923  LKSMEEIQGLTDLQ---LQEADEEKERIL--AQLRELEKKKKLEDAKSQ--EQVFGLDKE 975
            L+  E+ + L + +   LQ A EE E  L   + + L  + +L   KS+   +V   D+E
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586

Query: 976  LKKLK----KAVATSDKLATAELTIAKDQL---KSLHGTVMKI-------NQERAE---- 1017
            +++LK    +A      +  AE+    D L   K + G + ++       N++ AE    
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646

Query: 1018 ------ELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGAN 1071
                  +L++++     A ++  DL    A +E    LL ++ E+ ++ +E+T      +
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706

Query: 1072 SQ-VLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYI 1130
             Q +L+     + +  Q T +   +  L+   +  +   EN ++E      +        
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766

Query: 1131 SSMADPFKR 1139
            + MA+  K+
Sbjct: 1767 AMMAEELKK 1775



 Score =  115 bits (287), Expect = 7e-25
 Identities = 197/931 (21%), Positives = 396/931 (42%), Gaps = 89/931 (9%)

Query: 161  KIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLK--GNKISSLQDISKLKPLQ 218
            K+EG   M     ++L  N+ + I   L KK   L  L  K    ++ SLQ   K+K LQ
Sbjct: 1058 KLEGDLKMSQESIMDLE-NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116

Query: 219  DLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLE-------- 270
              I  +  E   +   H L+  I   RS  + E + ++ +  +EA    S +        
Sbjct: 1117 ARIEELEEE---IEAEHTLRAKIEKQRSDLARELEEISER-LEEASGATSAQIEMNKKRE 1172

Query: 271  -EVERLERDLEKKMIETEE----LKSKQTRFL----EEIKNQDKLNKSLKEEAMLQKQSC 321
             E +++ RDLE+  ++ E     L+ KQ   +    E+I N  ++ + L++E    K   
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232

Query: 322  EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKA 381
            +++ S++    E L +    + R C+   +   E+   K + + + ++    + A +   
Sbjct: 1233 DDMASNI----EALSKSKSNIERTCRTVEDQFSEIKA-KDEQQTQLIHDLNMQKARLQTQ 1287

Query: 382  PDESPYIGKSRYKRNMFATESYIIDSAQAVQIKK-MEPDEQLRNDHMNLRGHTPLDTQLE 440
              E  +  + +       T+S    + Q  ++K+ ME + + +N   +    +  D  L 
Sbjct: 1288 NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL- 1346

Query: 441  DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSG 500
               ++    Q   +EL   + KA  ++ +   +++   +AIQ  +  E  K    K+L+ 
Sbjct: 1347 -LREQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAK----KKLAQ 1399

Query: 501  RLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK 560
            RLQ   +  + A      +EK KQ + G   E++DL         +D + SH       K
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQG---EVEDLM--------RDLERSHTACATLDK 1448

Query: 561  EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISG 620
            +Q+    +K   + + +LDE  + +    +E + L  +L + + A  E +          
Sbjct: 1449 KQRN--FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV---------- 1496

Query: 621  LQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAEL 680
              + L T++ +    Q E   L ++     + L E E+ +   ++V  +  +++  L E+
Sbjct: 1497 --DQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK---KLVEQEKSDLQVALEEV 1551

Query: 681  ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSAL 740
            E +L+ +    + + + Q +LS  ++EL+ ++  +D E  QLK   +   R  +  QS L
Sbjct: 1552 EGSLEHEE---SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ---RAAEALQSVL 1605

Query: 741  QAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL--LKQQLKDFQNHLNH 798
             AE+     AL+  L K    +  E E    H+  +  +   +L  ++ QLKD Q HL+ 
Sbjct: 1606 DAEIRSRNDALR--LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663

Query: 799  VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
             +      +E  A V+     L     EM +        + L++ +   +    +    +
Sbjct: 1664 ALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQ 1723

Query: 859  DEAQVR-ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ-----M 912
            + + +  ++KL+ ++A  Q ++    +E R A E+A +A  +      E + +Q     +
Sbjct: 1724 NTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783

Query: 913  ENEIHYLQENLKSMEE-IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFG 971
            E     L++ +K ++  +     L L+   ++ +++  ++RELE +  +E  +  E + G
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843

Query: 972  LDKELKKLKKAV--ATSDKLATAELTIAKDQL----KSLHGTVMKINQERAEELQEAERF 1025
              K  +K+K+    A  D      L    D+L    KS      +  ++   +L    R 
Sbjct: 1844 AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903

Query: 1026 SRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
              +  +AA     AE+++  L+   R  G Q
Sbjct: 1904 QHELEEAAERADIAESQVNKLRAKSRDVGSQ 1934



 Score =  106 bits (264), Expect = 3e-22
 Identities = 118/606 (19%), Positives = 252/606 (41%), Gaps = 59/606 (9%)

Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
            C++      E + ++ E  +Q   SK   E  +W    +  + +  EEL      L Q  
Sbjct: 1344 CDLLREQYEEEQEAKAE--LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401

Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
            +  E   E  +      ++ K  + G VE LM +LE        ++K  ++ + ++ E  
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461

Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
                     +E  +K      +EL +      E   +L   + + KN  E+ +D    + 
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521

Query: 1472 QTESDAEELERRA----QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
            +T  + +E E+      QE +   V  ++   SL+ +   + + +++  ++  E+++ V 
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI 1581

Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKS 1587
             KD + + L +  ++  E LQ +  D E+  RN+   L+                +K++ 
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVL-DAEIRSRNDALRLK----------------KKMEG 1624

Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKS 1647
             +   + ++   +RQ+   ++ L  +QG +  ++  L +ALR  E    +     R    
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684

Query: 1648 LLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ-MSKHKTELKNILDMLQ 1706
            LLEEL     E+ V + + +    L +QE+    + +Q++  Q  S   T+ K   D+ Q
Sbjct: 1685 LLEELE----EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ 1740

Query: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766
             +      ++   + R +E EK + A+ +  +  E L++  Q     +E  K+ LE+  +
Sbjct: 1741 CQAEVENSIQ---ESRNAE-EKAKKAITDAAMMAEELKK-EQDTSAHLERMKKNLEQTVK 1795

Query: 1767 EIERMTAESRAL-----QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
            +++    E+  L     +  ++ L     +L+ + D+ +K+ A+  +     E   K   
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMT 1855

Query: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
               E+   N+ +LQ  +D+L     S        ++Q   +      +Q EL    +  +
Sbjct: 1856 YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERAD 1915

Query: 1882 LAKQDL 1887
            +A+  +
Sbjct: 1916 IAESQV 1921



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 122/609 (20%), Positives = 251/609 (41%), Gaps = 43/609 (7%)

Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
            S + + E+   K+  ER K E+ R  A  + L+  +  L +EK DLQ             
Sbjct: 846  SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905

Query: 1794 -EKCD-IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
             E+C+ + + K+    +V    E   + E+ N E L    R L+ +   L RD   L   
Sbjct: 906  EERCEGLIKSKILLEAKVKELTERLEEEEEMNSE-LVAKKRNLEDKCSSLKRDIDDLELT 964

Query: 1852 ISAMQQQLQEKREAVNSLQEELANVQDHLN-LAKQDLLHTTKHQDVLLSEQTRLQK--DI 1908
            ++ ++++       V +L EE+  ++++++ L K+       HQ  L   Q    K   +
Sbjct: 965  LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024

Query: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
             +   + E    + E   +Q + L+ ++E  K KL     M Q    + E+++ ++E   
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084

Query: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE----EERWCESLEKTLSQTK 2024
               + +  QL+ ++ D++    Q   K+   + R+  L+E    E      +EK  S   
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144

Query: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR 2084
            R+L E  ++L E SG   A  +      A+F  +R        + E   A+L++      
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204

Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQK 2144
            ++L + +   ++    ++KE + +++   D       L K  + ++     ++ Q +  K
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK 1264

Query: 2145 DLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLK 2204
              + +Q ++   +   K+     ++T    L+  + E  + +  + +  + L  +LE LK
Sbjct: 1265 AKDEQQTQLIHDLNMQKA----RLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320

Query: 2205 ENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLI 2264
                  M E   E K   +  H +        L  +    E   KA+L+  +SK    + 
Sbjct: 1321 RQ----MEE---ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373

Query: 2265 KGK--------RQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLT-EDSQLG 2315
            + +        ++TE    + ++    L E   +T   ++   SL + +  L  E   L 
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433

Query: 2316 QNQEKNASA 2324
            ++ E++ +A
Sbjct: 1434 RDLERSHTA 1442



 Score = 75.5 bits (184), Expect = 6e-13
 Identities = 92/508 (18%), Positives = 212/508 (41%), Gaps = 64/508 (12%)

Query: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL 1888
            L   + ++E+  +  D      +++  + + +E  E + SL +E  ++Q  +    ++L+
Sbjct: 844  LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903

Query: 1889 HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN----KLKLV 1944
               +  + L+  +  L+  + E   R E    EEE    +L   +  +E+     K  + 
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLE----EEEEMNSELVAKKRNLEDKCSSLKRDID 959

Query: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK---ELTDQKSKLDQVLSKVLAAEE 2001
              E+   +++KE+ + E+K++     L E+   LE+   +LT +K  L +      A ++
Sbjct: 960  DLELTLTKVEKEKHATENKVK----NLSEEMTALEENISKLTKEKKSLQE------AHQQ 1009

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
             +  LQ EE     L K  ++ ++Q  + E  L           ++   +RAD    + +
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL-----------EQEKKLRADLERAKRK 1058

Query: 2062 FLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARR 2121
               + K +++ +  L+      + Q+E+ L +++ E S +Q ++        D    + +
Sbjct: 1059 LEGDLKMSQESIMDLEN----DKQQIEEKLKKKEFELSQLQAKI-------DDEQVHSLQ 1107

Query: 2122 LMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPE 2181
              K++ ++Q    EL++           ++E    +R    + + ++   L+ +++ L E
Sbjct: 1108 FQKKIKELQARIEELEE-----------EIEAEHTLRAKIEKQRSDLARELEEISERLEE 1156

Query: 2182 LPADLEAILERNENLEGELESLKEN-----LPFTMNEGPFEEKLNFSQVHIMDEHWRGEA 2236
                  A +E N+  E E + ++ +     L          +K   S   + ++    + 
Sbjct: 1157 ASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQR 1216

Query: 2237 LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSA 2296
            +++KL   +  LK ++   M+   E L K K   E T  ++    D   E+       + 
Sbjct: 1217 VKQKLEKEKSELKMEIDD-MASNIEALSKSKSNIERTCRTVE---DQFSEIKAKDEQQTQ 1272

Query: 2297 SSPSLSQLESSL-TEDSQLGQNQEKNAS 2323
                L+  ++ L T++ +L    E+  S
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKES 1300



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 49/230 (21%), Positives = 105/230 (45%), Gaps = 27/230 (11%)

Query: 2063 LTERKKAEKQVASLKEAL----------KIQRSQLEKNLLEQKQENSCIQKEMATIELVA 2112
            L +  +AEK++A++KE            + +R +LE+ ++   QE + +Q ++ +     
Sbjct: 843  LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902

Query: 2113 QDNHERARRLMKELNQMQYEYTELKKQMANQK----DLERRQMEISDAMRTLKSEVKDEI 2168
             D  ER   L+K    ++ +  EL +++  ++    +L  ++  + D   +LK ++ D  
Sbjct: 903  MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD-- 960

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEE--KLNFSQV 2225
                  L   L ++  +  A   + +NL  E+ +L+EN+   T  +   +E  +     +
Sbjct: 961  ------LELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDL 1014

Query: 2226 HIMDEHWRG-EALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
             + ++   G   +  KL  + D L+  L      +A+ L + KR+ EG L
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD-LERAKRKLEGDL 1063


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  173 bits (439), Expect = 2e-42
 Identities = 246/1080 (22%), Positives = 463/1080 (42%), Gaps = 176/1080 (16%)

Query: 1315 VPEHHNLENEVSRLEDIMQHLKSK--KREERWMRASKRQSEKEMEE------LHHNIDDL 1366
            V E   L++ V+ L    Q L     K+E+ + +  ++ +E+ + +      LH    D 
Sbjct: 287  VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346

Query: 1367 LQEKKSLECEVEELHR----------TVQKRQQQKDFIDGNVESLMTEL-----EIEKSL 1411
             Q +  L      LHR            QK +++   ++   + L  E      + E+  
Sbjct: 347  QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406

Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
            +H   +  EI  +   LL+   +L EA   L E   +   + EK  +  ++  D +  L 
Sbjct: 407  QHGLQLQSEINQLHSKLLETERQLGEAHGRLKE---QRQLSSEKLMDKEQQVADLQLKLS 463

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
            + E   +E    + E    L K  QQ +  QA  +       + +  L+++ + +  KD 
Sbjct: 464  RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523

Query: 1532 DFQCLSKKKEKLTEELQKLQKDIE------MAERNEDHHLQVLKESEVLLQAKRAEL-EK 1584
              Q L    +K  E +  L+K+ E       A   E   L  L+E    LQ +  +L EK
Sbjct: 524  KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583

Query: 1585 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
            LK+Q  S +Q            +E LH                      +V E+  H+R 
Sbjct: 584  LKNQSESHKQA-----------QENLH---------------------DQVQEQKAHLRA 611

Query: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDM 1704
             +  +  L     ELN Q++E K +++ +  +I+ + E L       +  + +L+N LD 
Sbjct: 612  AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671

Query: 1705 ----LQLENHELQGLKLQHDQRVSELEKTQ--VAVLEEKLELENLQQISQQQKGE-IEWQ 1757
                LQ +  EL  +  Q DQ  ++L+  Q   + LE  L+    + +S +QK E +E Q
Sbjct: 672  AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731

Query: 1758 KQLLERDKREIERMTAESRALQSCVECLSKEKE---DLQEKCDIWEKKLAQTKRVLAAAE 1814
             + LE D  E++   ++ +ALQ     L ++++   DL+ +     K+L   K ++++  
Sbjct: 732  IKKLEADSLEVK--ASKEQALQD----LQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785

Query: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRD-----------KLSLHNDISAMQQQLQEKR 1863
             + + +   LE ++  + K ++E   L +D              L+N I     +LQ+ +
Sbjct: 786  LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845

Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
                +L  EL+ V+D L+          K  D L + ++  +K+  +      D +K  +
Sbjct: 846  MEKEALMTELSTVKDKLS----------KVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895

Query: 1924 TKQQQLQV-LQNEIEENK---LKLVQQEMMFQRLQKERESEESKLETSKVTLKE---QQH 1976
              + QLQV ++N ++E K     L +++    +L+ E  S + +L  ++ TLK+   ++ 
Sbjct: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955

Query: 1977 QLEKELTDQKSKLDQVLSKV--LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQL 2034
            QL+  + + K   +Q   ++  L  E ++  LQ+ E     LE  L Q   QL++  Q+L
Sbjct: 956  QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE-----LENKLQQ---QLTQAAQEL 1007

Query: 2035 VEKSGELLALQKEADSMRADFSLLRNQFL---TERKKAEKQVASLKEALKIQRSQLEKNL 2091
              +  ++  LQ   +  +  F  L++ F    +E     + + S++E L + +  L  N 
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067

Query: 2092 LEQKQENSCIQKEMATIELVAQDNHERARRLM---KELNQMQYEYTELKKQMANQK---- 2144
             +   +N  IQ+       + QD+ ++ ++L    K L  +Q E +  +K++ N+K    
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127

Query: 2145 DLE----RRQMEISDAMRTLKSEVKDEIR--TSLKNLNQFLPELPADLEAILERNENLEG 2198
            ++E    R++ EI+     LKS   + I+  T+LK+  Q L          +++   L+G
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL----------IQQKLELQG 1177

Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQL------ 2252
            + +SLK  +         +EK N             + L+++++  E+ LK +       
Sbjct: 1178 KADSLKAAVE--------QEKRN------------QQILKDQVKKEEEELKKEFIEKEAK 1217

Query: 2253 RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGE-LVTSTSADSASSPSLSQLESSLTED 2311
             H   K+ EV +K   + E     L  Q+ AL E L T      +S   +S+LE   T+D
Sbjct: 1218 LHSEIKEKEVGMKKHEENEA---KLTMQITALNENLGTVKKEWQSSQRRVSELEKQ-TDD 1273



 Score =  172 bits (436), Expect = 3e-42
 Identities = 214/966 (22%), Positives = 416/966 (43%), Gaps = 101/966 (10%)

Query: 1323 NEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHN-------IDDLLQEKKSLEC 1375
            ++V+ L   +Q L++  +EE+W     ++  ++ + L          + D   E +SLE 
Sbjct: 83   DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142

Query: 1376 EVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
            ++EE        +Q KD  +     L TE+   KS    E  + E    E+ + +   EL
Sbjct: 143  QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE--AAEQKVTRLTEEL 200

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE----ELERRAQETAVNL 1491
             +   ++ + ++EL       +  +E     K+ L+Q ++  +    E ER +++     
Sbjct: 201  NKEATVIQDLKTELL-----QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255

Query: 1492 VKADQQLRSLQADAKDLEQHKIK-QEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
             K   Q  S +A    L     K  +E+   + ++   K S  + L++K + LTE L K 
Sbjct: 256  KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE-LTQKNQTLTENLLKK 314

Query: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHK---- 1606
            ++D    E   +      K  +  L  K  + ++L+S++++ +  +  +  +L  K    
Sbjct: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374

Query: 1607 ---KEELHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELN 1660
               KEEL  ++      KA+   LQ+     E    +  + I ++ S L E   Q GE +
Sbjct: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434

Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
             ++ E++   +    + E++  +LQ+ L ++ +   E   + +  +L+ H+L   K QH 
Sbjct: 435  GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE--KVTNSTELQ-HQLDKTKQQHQ 491

Query: 1721 QRVSELEKTQVAVLEEKLELEN-LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
            ++ +  + T   + E + +LE  L+QI  + + +I+  + LL++ K  I  +  E   L 
Sbjct: 492  EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLY 550

Query: 1780 SCVECLSKEK---EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQ 1836
            + ++    E      LQEK    ++++ Q    L    E+ K  Q NL      V++ + 
Sbjct: 551  AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD---QVQEQKA 607

Query: 1837 ELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------------------ANVQD 1878
             L       LSL   ++ +  QL E +E V+ L  ++                  A++Q+
Sbjct: 608  HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667

Query: 1879 HLNLAK---QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNE 1935
            HL+ A+   QD           L + T   +D  E  ++ E   KE + K   L+    E
Sbjct: 668  HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727

Query: 1936 IEENKLKL--------VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKS 1987
            +E    KL          +E   Q LQ++R+   + LE  + T   +Q ++EKE+    +
Sbjct: 728  LEGQIKKLEADSLEVKASKEQALQDLQQQRQL-NTDLEL-RATELSKQLEMEKEIV-SST 784

Query: 1988 KLD-QVLSKVLAAEERVRTLQEEERWC--ESLEKTLSQTKRQLSEREQQLVEKSGELLAL 2044
            +LD Q  S+ L + ++  T QEEE+    +  E    +TK Q  E   ++     EL  +
Sbjct: 785  RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844

Query: 2045 QKEADSMRADFSLL--------------RNQFLTERKKAEKQVASLKEALKIQRSQL--- 2087
            + E +++  + S +              +++F  E +K +  +  L++  K  + QL   
Sbjct: 845  KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ 904

Query: 2088 -EKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL 2146
             E  L EQK+    ++KE      +  + +    +L++  N ++    E ++   N  +L
Sbjct: 905  MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964

Query: 2147 ERRQMEISDAMRTLKSEVKDEI--RTSLKN-----LNQFLPELPADLEAILERNENLEGE 2199
            ++   +    +  L+ E+K  +  +T L+N     L Q   EL A+ E I     N E  
Sbjct: 965  KQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024

Query: 2200 LESLKE 2205
             E+ K+
Sbjct: 1025 QETFKQ 1030



 Score =  167 bits (423), Expect = 1e-40
 Identities = 200/928 (21%), Positives = 414/928 (44%), Gaps = 117/928 (12%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
            +L+ ++SRLE+ ++   +   E +      +Q  +E + L  +    L+E ++   ++E+
Sbjct: 457  DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---DLEQ 513

Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSL--KHHEDIVDEIECIEKTLLKRRSELRE 1437
            + R +  + Q+      N+E+L+ + +   SL  K  ED+  +I+  E       ++L+E
Sbjct: 514  VLRQIGDKDQKIQ----NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL-NQLQE 568

Query: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
             +  L E  ++L+   EK KN  E    A+          E L  + QE   +L  A  +
Sbjct: 569  KNHTLQEQVTQLT---EKLKNQSESHKQAQ----------ENLHDQVQEQKAHLRAAQDR 615

Query: 1498 LRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA 1557
            + SL+    +L     + +E + +++  + AK          K     +LQ      + A
Sbjct: 616  VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675

Query: 1558 ERNEDHHLQV----LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
             +++   L      L +    LQ K+    +L+S +   +++   L+++    + ++  L
Sbjct: 676  LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735

Query: 1614 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLI 1673
            +   ++ KA  ++AL+            +++ + L  +L  +  EL+ Q+   K  ++  
Sbjct: 736  EADSLEVKASKEQALQ-----------DLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784

Query: 1674 KQEIEKEEENLQVVLRQMSKHKTE---LKNILDMLQLENHELQGLKLQHDQRVSELEKTQ 1730
            + +++K+ E L+ + ++++K + E   LK   + L  E       K+QH++  + ++ T 
Sbjct: 785  RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET------KIQHEELNNRIQTTV 838

Query: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKE-K 1789
              + + K+E E L       K ++      L+  K E E+   + +A    +E   KE K
Sbjct: 839  TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898

Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLH 1849
              LQ + +   K+  + K+ L   +E S   +  L  ++  + + Q  L Q  +++  L 
Sbjct: 899  HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958

Query: 1850 NDISAMQQQLQEKREAVNSLQEELA-----------NVQDHLNLAKQDLLHTTKHQDVLL 1898
             +I+ ++Q  ++K++ + +LQ EL             +Q  L  A Q+L    +   VL 
Sbjct: 959  GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018

Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
            +   + Q+   +  + F   + E    +Q L+ +     E KL L Q++++  R Q   +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSV-----EEKLSLAQEDLISNRNQIGNQ 1073

Query: 1959 SEE-SKLETSKVTL------KEQQHQ---------------LEKELTDQKSKLDQVLSKV 1996
            ++   +L+T+K TL      KEQQ Q                EKEL ++KSKL ++  ++
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI-EEI 1132

Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS 2056
               +E+  T   EE     LE     T   L + +Q L+++    L LQ +ADS++A   
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITN--LKDAKQLLIQQK---LELQGKADSLKA--- 1184

Query: 2057 LLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNH 2116
                    E++K  +Q+  LK+ +K +  +L+K  +E++ +   +  E+   E+  + + 
Sbjct: 1185 ------AVEQEKRNQQI--LKDQVKKEEEELKKEFIEKEAK---LHSEIKEKEVGMKKHE 1233

Query: 2117 ERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLN 2176
            E   +L  ++  +      +KK+  +    +RR  E+         +  D++R  +  L 
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSS---QRRVSELE--------KQTDDLRGEIAVLE 1282

Query: 2177 QFLPELPADLEAILERNENLEGELESLK 2204
              +     +  A+LER    EGE+E L+
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQ 1310



 Score =  162 bits (411), Expect = 3e-39
 Identities = 190/871 (21%), Positives = 393/871 (45%), Gaps = 115/871 (13%)

Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKR 1387
            LE +++ +  K ++ + + A  ++S++ +  L    +DL  + ++ E E   L++  +K 
Sbjct: 511  LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570

Query: 1388 QQQKDFIDGNVESLMTELEIEKSLKH--HEDIV----------DEIECIEKTLLKRRSEL 1435
               ++ +    E L  + E  K  +   H+ +           D +  +E ++ +  S+L
Sbjct: 571  HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630

Query: 1436 READRLLAE------AESELSCTKEKTKNA----VEKFTDAKRSLLQT-ESDAEELERRA 1484
             E+   +++      A++EL  + E  K A    ++   D  ++ LQ  + +  ++  + 
Sbjct: 631  NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690

Query: 1485 QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLT 1544
             +    L    +    L++  K+ ++  +  E+  +E+   +   ++D   +   KE+  
Sbjct: 691  DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750

Query: 1545 EELQK---LQKDIEMAERNEDHHLQVLKE----SEVLLQAKRAELEKLKSQVTSQQQEMA 1597
            ++LQ+   L  D+E+        L++ KE    + + LQ K   LE +K ++T Q++E  
Sbjct: 751  QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810

Query: 1598 VLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKG 1657
            +L +      +E           K   +E     +T VTE      E ++L+ ELS  K 
Sbjct: 811  ILKQDFETLSQE----------TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860

Query: 1658 ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKL 1717
            +L    S+    L   K E EKE +  +  +  + K   ELK+ L + Q+EN     LK 
Sbjct: 861  KL----SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV-QMENT----LKE 911

Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQI--------------SQQQKGEIEWQKQLLER 1763
            Q + + S LEK + A  + KLEL ++Q+                QQ +G I   KQ  E+
Sbjct: 912  QKELKKS-LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970

Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
             K++IE       ALQ  ++    +K +L+ K    +++L Q  + LAA +E   + Q+N
Sbjct: 971  KKKQIE-------ALQGELKIAVLQKTELENKL---QQQLTQAAQELAAEKEKISVLQNN 1020

Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
             EK        Q+   QL  D     +++ A +Q L+   E ++  QE+L + ++ +   
Sbjct: 1021 YEKS-------QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073

Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
             + +      +  L  +  + ++ + E     +D QKE+  K+++L   ++++ E +   
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133

Query: 1944 VQQEMMFQRLQKERESEESKLETSK--VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
             +QE    +L +E +S   KLE+ K    LK+ +  L ++  + + K D + + V     
Sbjct: 1134 CRQEKEITKLNEELKSH--KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV----- 1186

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
                  E+E+  + + K   Q K++  E +++ +EK  +L +  KE +       +   +
Sbjct: 1187 ------EQEKRNQQILK--DQVKKEEEELKKEFIEKEAKLHSEIKEKE-------VGMKK 1231

Query: 2062 FLTERKKAEKQVASLKEAL---KIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHER 2118
                  K   Q+ +L E L   K +    ++ + E +++   ++ E+A +E   Q+N + 
Sbjct: 1232 HEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291

Query: 2119 ARRLMK-------ELNQMQYEYTELKKQMAN 2142
             R L++       E+ ++Q +  EL++++ N
Sbjct: 1292 RRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322



 Score =  139 bits (350), Expect = 3e-32
 Identities = 200/937 (21%), Positives = 416/937 (44%), Gaps = 118/937 (12%)

Query: 240  TIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEE 299
            TI  LRS  +   Q V    ++    + S+ E+ +  + L + +++ E+  +K    LEE
Sbjct: 268  TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK----LEE 323

Query: 300  IKNQDKLNKSLKEEAMLQKQ-SCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAF 358
              N++ ++K   +  + QK   C++L+S L+     L +  +EL+   +   +L++EL+ 
Sbjct: 324  KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS- 382

Query: 359  YKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEP 418
             +++ K++ L    +E+ ++ +  +E    G              +      +  K +E 
Sbjct: 383  -EVETKYQHLK---AEFKQLQQQREEKEQHGLQ------------LQSEINQLHSKLLET 426

Query: 419  DEQLRNDHMNLRGHTPLDTQ-LEDKEKKISAAQTRLSELHDEIEKAE------QQILRAT 471
            + QL   H  L+    L ++ L DKE++++  Q +LS L +++++        Q  L  T
Sbjct: 427  ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486

Query: 472  EEFKQLEEAIQLK---KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAG 528
            ++  Q ++A+Q     K+ EA  DL  +Q+   L+ +    Q+  +LE  ++K K+ I+ 
Sbjct: 487  KQQHQEQQALQQSTTAKLREAQNDL--EQV---LRQIGDKDQKIQNLEALLQKSKENISL 541

Query: 529  KQKEIKDLQIAIDSLDS--------------------------KDPKHSHMKAQKSGKEQ 562
             +KE +DL   I + +                           K+   SH +AQ++  +Q
Sbjct: 542  LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601

Query: 563  ------QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL---TEGQIAANEA---- 609
                   L     +   LE+ ++E+ S++ +  E++  L+ Q+   TE  ++A  A    
Sbjct: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661

Query: 610  ---LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIV 666
               L+  L+   + LQ+    +    TQ      KL+D++E   Q  + +++ +++   +
Sbjct: 662  RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721

Query: 667  AMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN---QLK 723
                E +  ++ +LE+   +  EV AS +Q   DL   + +L   L LR  E +   +++
Sbjct: 722  EQKTEELEGQIKKLEA---DSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLEME 777

Query: 724  EELEKVTRLT-QLEQSALQA------ELEKERQALKNALGKAQFSEEKEQENSELH---- 772
            +E+   TRL  Q +  AL++      + E+E+Q LK        S+E + ++ EL+    
Sbjct: 778  KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF--ETLSQETKIQHEELNNRIQ 835

Query: 773  ---AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK--LKLGTGEM 827
                +L+ ++ +   L  +L   ++ L+ V D L   +    + ++  +   L L     
Sbjct: 836  TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895

Query: 828  NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR 887
             +     V  ++    QK+  + L + K    + ++    +QE++   Q  L   ++E +
Sbjct: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955

Query: 888  QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
            Q      E + + ++++ +    Q E +I  LQ+     +  Q LT    QE   EKE+I
Sbjct: 956  QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ-AAQELAAEKEKI 1014

Query: 948  LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLK---KAVATSDKLATAELTIAKDQLKSL 1004
                   EK ++    + Q   +G + EL   +   K+V     LA  +L   ++Q+ + 
Sbjct: 1015 SVLQNNYEKSQE-TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073

Query: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQ-NLLRQKGEQFRLEMEK 1063
            +  + ++   +A   Q++ +  ++  +  + L   + E  L +  L+ +K +   +E  K
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133

Query: 1064 TGVGTGANSQVLEIEKLNETMERQRTE-IARLQNVLD 1099
                     Q  EI KLNE ++  + E I  + N+ D
Sbjct: 1134 C-------RQEKEITKLNEELKSHKLESIKEITNLKD 1163



 Score =  125 bits (314), Expect = 5e-28
 Identities = 181/922 (19%), Positives = 402/922 (43%), Gaps = 126/922 (13%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
            +EV+ L+  L+++   +EELK +  ++ + ++ Q+     L  ++  + QS E+   +  
Sbjct: 90   QEVQDLQASLKEEKWYSEELKKELEKY-QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ 148

Query: 330  TKN-------ELLKQKTIELTRAC---QKQYELEQEL---AFYKIDAKFEPLNYYPSEYA 376
            T+N       +L +QK  +L       + +Y+ E+ L   A  K+    E LN   +   
Sbjct: 149  TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQ 208

Query: 377  EIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
            ++     + P I            E   +   + VQ++ +  +  L  +    R    L 
Sbjct: 209  DLKTELLQRPGI------------EDVAVLKKELVQVQTLMDNMTLERE----RESEKLK 252

Query: 437  TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLY 495
             + +  + + ++++  +S+L  E+ K  Q++    +E ++L+ ++ +L + ++   + L 
Sbjct: 253  DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312

Query: 496  KQLSGRLQLVNKLRQEALDL----------ELQMEKQKQEIAGKQKEIKDLQIAI----- 540
            K+     +L  K  +E++            +L  ++ +  ++  +  +  + + +     
Sbjct: 313  KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 541  ------DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKD 594
                  + L   + K+ H+KA+    +QQ +   +   QL+S ++++ S++ +   ++ +
Sbjct: 373  ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432

Query: 595  LEEQLTEGQIAANEALK------KDLEGVISGLQEYLGTIKGQATQAQNECRKLR---DE 645
               +L E +  ++E L        DL+  +S L+E L      +T+ Q++  K +    E
Sbjct: 433  AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492

Query: 646  KETLLQRLT-EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDL--- 701
            ++ L Q  T ++ + ++ LE V     +  +++  LE+ LQ+  E  + L++ + DL   
Sbjct: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552

Query: 702  -------SAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA 754
                   +A   +L+ + +    +  QL E+L+  +   +  Q  L  ++++++  L+ A
Sbjct: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612

Query: 755  LGK------------AQFSEEKE---QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
              +            +Q +E KE   Q + ++ AK + L         Q  D QNHL+  
Sbjct: 613  QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672

Query: 800  VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
             + L   ++      EL +          I +  D +   L D Q+  S++ +  K  ++
Sbjct: 673  QNALQDKQQ------ELNK----------ITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716

Query: 860  EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
            +    E+K  EE+  Q +KL     E + + E+AL+     D +Q       +E     L
Sbjct: 717  KYLSLEQK-TEELEGQIKKLEADSLEVKASKEQALQ-----DLQQQRQLNTDLELRATEL 770

Query: 920  QENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL---------EDAKSQEQVF 970
             + L+  +EI   T L LQ+  E  E I  +L + E++K++         ++ K Q +  
Sbjct: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830

Query: 971  G--LDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRK 1028
               +   + +L+K     + L T EL+  KD+L  +  ++     E  +E Q+ +     
Sbjct: 831  NNRIQTTVTELQKVKMEKEALMT-ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889

Query: 1029 AAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTG---VGTGANSQVLEIEKLNETME 1085
              +  ++L + + ++++   L  QK  +  LE EK     +    NS   ++ +   T++
Sbjct: 890  LEKTCKEL-KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948

Query: 1086 RQRTEIARLQ-NVLDLTGSDNK 1106
            +   E  +LQ N+ +L  S  +
Sbjct: 949  QNEKEEQQLQGNINELKQSSEQ 970



 Score =  124 bits (310), Expect = 1e-27
 Identities = 148/685 (21%), Positives = 308/685 (44%), Gaps = 85/685 (12%)

Query: 1312 HCNVPEHH---------NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHN 1362
            HC+  E H         +LE +   LE  ++ L++   E   ++ASK Q+ +++++    
Sbjct: 703  HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE---VKASKEQALQDLQQQRQL 759

Query: 1363 IDDL----LQEKKSLECE-----------------VEELHRTVQKRQQQKDFIDGNVESL 1401
              DL     +  K LE E                 +E + + + K++++K  +  + E+L
Sbjct: 760  NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819

Query: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE 1461
              E +I+     HE++ + I+     L K + E       L+  + +LS   +  KN+  
Sbjct: 820  SQETKIQ-----HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874

Query: 1462 KFTD----AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
            +F       K ++L  E   +EL+ + Q    N +K  ++L+      K LE+ K    +
Sbjct: 875  EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK------KSLEKEKEASHQ 928

Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQA 1577
            +  E+N +   +    Q   K+ EK  ++LQ    +++ +   +   ++ L+    +   
Sbjct: 929  LKLELNSM-QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987

Query: 1578 KRAELE-KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1636
            ++ ELE KL+ Q+T   QE+A        +KE++ +LQ +  +++   ++         +
Sbjct: 988  QKTELENKLQQQLTQAAQELAA-------EKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040

Query: 1637 EKCNHIREVKSLLEELSF----------QKGELNVQISERKTQLTLIKQEIEKEEENLQV 1686
            E     +++KS+ E+LS           Q G  N  I E KT    ++Q+  K+E+ LQ 
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100

Query: 1687 ---VLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL-EKTQVAVLEEKLELEN 1742
                L+ + K K+  +  L   + +  E++ +K + ++ +++L E+ +   LE   E+ N
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160

Query: 1743 LQQISQ---QQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIW 1799
            L+   Q   QQK E++ +   L   K  +E+   E R  Q   + + KE+E+L+++   +
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSL---KAAVEQ---EKRNQQILKDQVKKEEEELKKE---F 1211

Query: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
             +K A+    +   E   K  + N  KL + +  L + L  + ++  S    +S +++Q 
Sbjct: 1212 IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQT 1271

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQ 1919
             + R  +  L+  + N QD      +  L      + L ++   LQ+ +       ++  
Sbjct: 1272 DDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331

Query: 1920 KEEETKQ-QQLQVLQNE-IEENKLK 1942
            +E ++ Q +  Q L  +  E+N+++
Sbjct: 1332 RENQSLQIKHTQALNRKWAEDNEVQ 1356



 Score =  119 bits (297), Expect = 5e-26
 Identities = 151/769 (19%), Positives = 335/769 (43%), Gaps = 88/769 (11%)

Query: 1319 HNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE 1378
            ++L+   + L+D  Q L     +   + A  +  ++   +L  ++ +  ++  SLE + E
Sbjct: 667  NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726

Query: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLK-----HHEDIVDEIECIEKTLLKRRS 1433
            EL   ++K +     +  + E  + +L+ ++ L         ++  ++E  ++ +   R 
Sbjct: 727  ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786

Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
            +L++    L   + +L  TK++ +  + K  D +    +T+   EEL  R Q T   L K
Sbjct: 787  DLQKKSEALESIKQKL--TKQEEEKQILK-QDFETLSQETKIQHEELNNRIQTTVTELQK 843

Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
               +  +L  +   ++    K  + LK          S+F+  ++K +    +L+K  K+
Sbjct: 844  VKMEKEALMTELSTVKDKLSKVSDSLKN-------SKSEFEKENQKGKAAILDLEKTCKE 896

Query: 1554 IE-MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL 1612
            ++   +   ++ L+  KE +  L+ ++    +LK ++ S Q+++      L   ++E   
Sbjct: 897  LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956

Query: 1613 LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTL 1672
            LQG++ + K   +           +K   I  ++  L+    QK EL  ++ +   QLT 
Sbjct: 957  LQGNINELKQSSE-----------QKKKQIEALQGELKIAVLQKTELENKLQQ---QLTQ 1002

Query: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
              QE+  E+E + V+     K +   K     LQ + +  +   L   Q +  +E+ +++
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFK----QLQSDFYGRESELLATRQDLKSVEE-KLS 1057

Query: 1733 VLEEKLELENLQQISQQQK--GEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKE 1790
            + +E L + N  QI  Q K   E++  K  LE+D  + E+   E            K  +
Sbjct: 1058 LAQEDL-ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER----------CKALQ 1106

Query: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN 1850
            D+Q++  + EK+L   K  LA  EE    ++  + KL           ++L   KL    
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN----------EELKSHKLESIK 1156

Query: 1851 DISAMQQQLQEKREAVNSLQEELANVQDHLNLA-KQDLLHTTKHQDVLLSEQTRLQKDIS 1909
            +I+     L++ ++ +   + EL    D L  A +Q+  +    +D +  E+  L+K+  
Sbjct: 1157 EIT----NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212

Query: 1910 EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV 1969
            E     ++ +   E K++++ + ++  EEN+ KL  Q               + L  +  
Sbjct: 1213 E-----KEAKLHSEIKEKEVGMKKH--EENEAKLTMQ--------------ITALNENLG 1251

Query: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCESLEKTLSQTKR 2025
            T+K++    ++ +++ + + D +  ++   E  V+  Q+E R     C   E  + + + 
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT 1311

Query: 2026 QLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
            ++ E +++L   +  +  L +E  S++   +   N+   E  + +  +A
Sbjct: 1312 KVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMA 1360



 Score =  117 bits (293), Expect = 1e-25
 Identities = 200/910 (21%), Positives = 410/910 (45%), Gaps = 112/910 (12%)

Query: 173  KLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKL-KPLQDLISLI------- 224
            KL  A N++E +   +G K    ++ NL+     S ++IS L K  +DL + I       
Sbjct: 503  KLREAQNDLEQVLRQIGDK--DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560

Query: 225  LVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQE----------AFERFSLEEVER 274
             V N +    H LQ  +  L   E L+ Q  + +  QE          A  R + + V  
Sbjct: 561  AVLNQLQEKNHTLQEQVTQLT--EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618

Query: 275  LERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL 334
            LE  + +   +  E K K ++   +IK + +L  S +     Q+    +L++ L+T    
Sbjct: 619  LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA---DLQNHLDTAQNA 675

Query: 335  LKQKTIELTRACQKQYELEQELAFYKIDAKFEP-------LNYYPSEYAEIDKAPDESPY 387
            L+ K  EL +      +L+Q  A  K+  K E        L  Y  +Y  +++  +E   
Sbjct: 676  LQDKQQELNKITT---QLDQVTA--KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL-- 728

Query: 388  IGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKIS 447
              + + K+     +S  + +++   ++ ++   QL  D + LR  T L  QLE +++ +S
Sbjct: 729  --EGQIKK--LEADSLEVKASKEQALQDLQQQRQLNTD-LELRA-TELSKQLEMEKEIVS 782

Query: 448  AAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVN- 506
            + +  L +  + +E  +Q++ +  EE + L++    + +S+  K + +++L+ R+Q    
Sbjct: 783  STRLDLQKKSEALESIKQKLTKQEEEKQILKQ--DFETLSQETK-IQHEELNNRIQTTVT 839

Query: 507  -----KLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKE 561
                 K+ +EAL  EL   K K            L    DSL  K+ K    K  + GK 
Sbjct: 840  ELQKVKMEKEALMTELSTVKDK------------LSKVSDSL--KNSKSEFEKENQKGKA 885

Query: 562  QQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGL 621
              LD+  K  ++L+ +L   +    KE +E+K   E+  E    A+  LK +L  +   L
Sbjct: 886  AILDL-EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE----ASHQLKLELNSMQEQL 940

Query: 622  QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL---- 677
             +   T+K    + Q     + + K++  Q+  ++E  + +L+I  +    +  +L    
Sbjct: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000

Query: 678  --------AELE--SALQEQHEVNA-SLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL 726
                    AE E  S LQ  +E +  + +Q Q D    E+EL A    +D ++ + K  L
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA--TRQDLKSVEEKLSL 1058

Query: 727  EKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLK 786
             +   ++   Q   Q +L +E +  K  L   Q S +KEQ+  E    L+ +Q + +L +
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATL--EQDSAKKEQQLQERCKALQDIQKEKSLKE 1116

Query: 787  QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE--MNIHSPSDVLGKSLADLQ 844
            ++L + ++ L  + +   R E+   +++E  +  KL + +   N+     +L +   +LQ
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176

Query: 845  KQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF--RQACERALEARMNFDK 902
             +   + A  + E+   Q+    L++++  ++E+L   ++EF  ++A   +         
Sbjct: 1177 GKADSLKAAVEQEKRNQQI----LKDQVKKEEEEL---KKEFIEKEAKLHSEIKEKEVGM 1229

Query: 903  RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
            ++HE    ++  +I  L ENL ++++    +  ++ E +++ + +  ++  LE   +   
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ--- 1286

Query: 963  AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE-RAEELQE 1021
              +Q++   L   L++  K     +KL T  L + + +L +    V ++ +E ++ +++ 
Sbjct: 1287 -NNQDERRAL---LERCLKGEGEIEKLQTKVLELQR-KLDNTTAAVQELGRENQSLQIKH 1341

Query: 1022 AERFSRKAAQ 1031
             +  +RK A+
Sbjct: 1342 TQALNRKWAE 1351



 Score =  102 bits (254), Expect = 4e-21
 Identities = 101/477 (21%), Positives = 217/477 (45%), Gaps = 45/477 (9%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
            +LE E      +   L S + +    + + +Q+EKE ++L  NI++L Q  +  + ++E 
Sbjct: 918  SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977

Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
            L   ++    QK  ++  ++  +T+   E + +      ++I  ++    K +   ++  
Sbjct: 978  LQGELKIAVLQKTELENKLQQQLTQAAQELAAEK-----EKISVLQNNYEKSQETFKQLQ 1032

Query: 1440 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESD-------AEELERRAQETAVNLV 1492
                  ESEL  T++  K+  EK + A+  L+   +         +EL+        +  
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092

Query: 1493 KADQQLRSLQADAKDLEQHK-IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
            K +QQL+      +D+++ K +K++E++ E +K+  A+  + +C  +K      E+ KL 
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL--AEIEEIKCRQEK------EITKLN 1144

Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAEL----EKLKSQVTSQQQEMAVLDRQLGHKK 1607
            ++++  +      +  LK+++ LL  ++ EL    + LK+ V  +++   +L  Q+  ++
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204

Query: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERK 1667
            EE   L+   ++ +A L   ++  E EV  K +   E K            L +QI+   
Sbjct: 1205 EE---LKKEFIEKEAKLHSEIK--EKEVGMKKHEENEAK------------LTMQITALN 1247

Query: 1668 TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELE 1727
              L  +K+E +  +  +  + +Q    + E+  +   +Q    E + L  +  +   E+E
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307

Query: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
            K Q  VLE + +L+N     Q+   E    + L  +  + + R  AE   +Q+C+ C
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRE---NQSLQIKHTQALNRKWAEDNEVQNCMAC 1361



 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 183/859 (21%), Positives = 360/859 (41%), Gaps = 137/859 (15%)

Query: 152  LNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDI 211
            L  + +++  +E   N  N Q LN +  ++  + + +  K K+  +L+ +  K +   D+
Sbjct: 609  LRAAQDRVLSLETSVNELNSQ-LNESKEKVSQLDIQI--KAKTELLLSAEAAKTAQRADL 665

Query: 212  SK--------LKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
                      L+  Q  ++ I  +   VT    LQ    H   LES           +E 
Sbjct: 666  QNHLDTAQNALQDKQQELNKITTQLDQVTAK--LQDKQEHCSQLES---------HLKEY 714

Query: 264  FERF-SLEE-VERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSC 321
             E++ SLE+  E LE  ++K   ++ E+K+ + + L++++ Q +LN  L+  A    +  
Sbjct: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774

Query: 322  EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKA 381
            E  K  +++    L++K+  L    QK  + E+E    K D  FE L+            
Sbjct: 775  EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD--FETLS------------ 820

Query: 382  PDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED 441
                                          Q  K++ +E      +N R  T + T+L+ 
Sbjct: 821  ------------------------------QETKIQHEE------LNNRIQTTV-TELQK 843

Query: 442  KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGR 501
             + +  A  T LS + D++ K    +  +  EF   E+  Q  K +    +   K+L  +
Sbjct: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF---EKENQKGKAAILDLEKTCKELKHQ 900

Query: 502  LQL-VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK 560
            LQ+ +    +E  +L+  +EK+K+     + E+  +Q  +    +   ++   + Q  G 
Sbjct: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960

Query: 561  EQQLDIMNKQ-YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVIS 619
              +L   ++Q  +Q+E+   E+   + ++TE    L++QLT  Q A   A +K+   V+ 
Sbjct: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT--QAAQELAAEKEKISVLQ 1018

Query: 620  GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAE 679
               E     K Q T  Q +      E E L  R  +++   ++L +   D  + R ++  
Sbjct: 1019 NNYE-----KSQETFKQLQSDFYGRESELLATR-QDLKSVEEKLSLAQEDLISNRNQIGN 1072

Query: 680  LESALQEQHEVNASLQQTQGDLSAYEAELEARLN-LRDAEANQLKEELEKVTRLTQLEQS 738
                +QE     A+L+Q   D +  E +L+ R   L+D +  +  +E E V   ++L   
Sbjct: 1073 QNKLIQELKTAKATLEQ---DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL--- 1126

Query: 739  ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
               AE+E+ +   +  + K   +EE +    E   ++ +L+D   LL QQ  + Q     
Sbjct: 1127 ---AEIEEIKCRQEKEITK--LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG---- 1177

Query: 799  VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
                  + + + A V++ +R         N     D + K   +L+K+F E  A+   E 
Sbjct: 1178 ------KADSLKAAVEQEKR---------NQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222

Query: 859  DEAQV-------RERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ 911
             E +V        E KL  ++    E L T ++E++ +  R  E          E +   
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL---------EKQTDD 1273

Query: 912  MENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFG 971
            +  EI  L+  +++ ++ +     +  + + E E++  Q + LE ++KL++  +  Q  G
Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL--QTKVLELQRKLDNTTAAVQELG 1331

Query: 972  LDKELKKLKKAVATSDKLA 990
             + +  ++K   A + K A
Sbjct: 1332 RENQSLQIKHTQALNRKWA 1350



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 139/666 (20%), Positives = 290/666 (43%), Gaps = 115/666 (17%)

Query: 470  ATEEFKQLEEAIQLKKISEAGKDLLY---KQLSGRLQLVNKLRQEALDLELQMEKQKQEI 526
            A E FK  E       + +AG D  +     L+ +   V  LRQE  DL+  ++++K   
Sbjct: 53   ADELFKHYEA------VHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYS 106

Query: 527  AGKQKEIK---------------------DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLD 565
               +KE++                     +LQ     L+    ++ ++K  K   EQ+  
Sbjct: 107  EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166

Query: 566  IMNKQYQQLESRLDE--------------ILSRIAKETEEIKDLEEQLTEGQ-IAANEAL 610
             +  +   ++S+ DE              +   + KE   I+DL+ +L +   I     L
Sbjct: 167  QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226

Query: 611  KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE----KETLLQRLTEVEQERDQLEIV 666
            KK+L  V + +       + ++ + ++EC+KL+ +    + T+ Q  +E+ +   ++ + 
Sbjct: 227  KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286

Query: 667  AMDAENMRKELAEL--------ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAE 718
              + + ++  + EL        E+ L+++ +    L++   + S  +  ++A L+ +D +
Sbjct: 287  VQELQKLKSSVNELTQKNQTLTENLLKKEQDY-TKLEEKHNEESVSKKNIQATLHQKDLD 345

Query: 719  ANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHL 778
              QL+      +RL+  E S  +  +E           K + +++ ++E SE+  K +HL
Sbjct: 346  CQQLQ------SRLSASETSLHRIHVELSE--------KGEATQKLKEELSEVETKYQHL 391

Query: 779  QDDNNLLKQQLKDFQNH-------LNHVVDGLVRPE----EVAARVDELRR--KLKLGTG 825
            + +   L+QQ ++ + H       +N +   L+  E    E   R+ E R+    KL   
Sbjct: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451

Query: 826  EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQE---KLATG 882
            E  +      L   L+ L++Q  E +  S   + +    +++ QE+ ALQQ    KL   
Sbjct: 452  EQQVAD----LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507

Query: 883  QEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQ-EAD 941
            Q +  Q        R   DK Q   +IQ +E  +   +EN+  +E+ +   DL  + +A 
Sbjct: 508  QNDLEQV------LRQIGDKDQ---KIQNLEALLQKSKENISLLEKER--EDLYAKIQAG 556

Query: 942  EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
            E +  +L QL+E     + +  +  E++    +  K+ ++ +    +   A L  A+D++
Sbjct: 557  EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616

Query: 1002 KSLHGTVMKINQERAEELQEAERFSRK---------AAQAARDLTRAEAE--IELLQNLL 1050
             SL  +V ++N +  E  ++  +   +         +A+AA+   RA+ +  ++  QN L
Sbjct: 617  LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676

Query: 1051 RQKGEQ 1056
            + K ++
Sbjct: 677  QDKQQE 682


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  170 bits (430), Expect = 2e-41
 Identities = 230/1044 (22%), Positives = 473/1044 (45%), Gaps = 116/1044 (11%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ +  + ++     + A KR+ E E  EL  +IDDL      +E E       V+
Sbjct: 921  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
               ++   +D  +  L  E   +K+L+  H+  +D+++  E    TL K +++L ++ D 
Sbjct: 981  NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD 1037

Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
            L    E E +L    E+ K  +E     A+ S + TE+D ++L  + ++    +     +
Sbjct: 1038 LEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGK 1097

Query: 1498 LRSLQADAKDLEQHKIKQ-EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            +   QA A  L Q KIK+ +  ++E+ + + A+ +      K++  L+ EL+++ + +E 
Sbjct: 1098 IEDEQALAIQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELE----------------------KLKSQVTSQQQ 1594
            A       +++ K+ E   Q  R +LE                      +L  Q+ S Q+
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216

Query: 1595 EMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
                L+++    K E++ L  +M    +AKA+ ++  R  E +++E      E + L+ E
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE 1276

Query: 1652 LSFQK-------GELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
            LS QK       GE + Q+ E+    +QL+  KQ   ++ E L+  L + +K K+ L + 
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHA 1336

Query: 1702 L-------DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI 1754
            L       D+L+ +  E Q  K +  + +S+   ++VA    K E + +Q+  + ++ + 
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSK-ANSEVAQWRTKYETDAIQRTEELEEAKK 1395

Query: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL-------QEKCDIWEKKLAQTK 1807
            +  ++L + ++  +E + ++  +L+   + L  E EDL          C   +KK     
Sbjct: 1396 KLAQRLQDAEE-HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454

Query: 1808 RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVN 1867
            +VL  AE   K E++            Q EL+   ++  SL  ++  ++   +E  + + 
Sbjct: 1455 KVL--AEWKQKYEET------------QAELEASQKESRSLSTELFKVKNAYEESLDHLE 1500

Query: 1868 SLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQ---KEEET 1924
            +L+ E  N+Q  ++   + +    KH   L   + +L  + SE     E+ +   + EE 
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEG 1560

Query: 1925 KQQQLQVLQNEIE-ENKLKLVQQEMMFQRLQKER----ESEESKLETSKVTLKEQQHQLE 1979
            K  ++Q+  N+++ E   K+ +++    +L++      ES +S L+ +++  +    +++
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLD-AEIRSRNDALRIK 1619

Query: 1980 KELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
            K++    ++++  L+     A E +R L+  +   +  +  L    R   + ++QL    
Sbjct: 1620 KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE 1679

Query: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKI---QRSQLEKNLLEQK 2095
                 +Q E + +RA  SL R +    RK AE+++    E +++   Q + L     + +
Sbjct: 1680 RRANLMQAEVEELRA--SLERTE--RGRKMAEQELLDASERVQLLHTQNTSLINTKKKLE 1735

Query: 2096 QENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISD 2155
             + S IQ EM  I   A++  E+A++ + +   M     ELKK+      LER +  +  
Sbjct: 1736 TDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMA---EELKKEQDTSAHLERMKKNMEQ 1792

Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES-LKENLPFTMNEG 2214
             ++ L+  + +  + +LK   + + +L A       R   LE E+ES  K N+     +G
Sbjct: 1793 TVKDLQLRLDEAEQLALKGGKKQIQKLEA-------RVRELESEVESEQKHNVEAV--KG 1843

Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
              + +    ++    E  R   LR  L+   D+L+ +++    +QAE   + + Q+   L
Sbjct: 1844 LRKHERRVKELTYQTEEDRKNILR--LQDLVDKLQTKVK-AYKRQAE---EAEEQSNVNL 1897

Query: 2275 HSLRRQVDALGELVTSTSADSASS 2298
               R+    L E      AD A S
Sbjct: 1898 AKFRKLQHELEE--AKERADIAES 1919



 Score =  163 bits (413), Expect = 2e-39
 Identities = 222/1060 (20%), Positives = 463/1060 (43%), Gaps = 153/1060 (14%)

Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS 1410
            ++EKEM  +    +   +E    E + +EL   +    Q+K+ +         +L+++  
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL---------QLQVQAE 898

Query: 1411 LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
                 D  +  + + KT ++  ++++E     AE E E++           + T  KR L
Sbjct: 899  ADALADAEERCDQLIKTKIQLEAKIKEVTE-RAEDEEEINA----------ELTAKKRKL 947

Query: 1471 LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
               E +  EL++   +  + L K              +E+ K   E  +K + + +A  D
Sbjct: 948  ---EDECSELKKDIDDLELTLAK--------------VEKEKHATENKVKNLTEEMAGLD 990

Query: 1531 SDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590
                 L+K+K+ L E  Q+   D++M    E+  +  L +++  L+ +  +LE      +
Sbjct: 991  ETIAKLTKEKKALQEAHQQTLDDLQM----EEDKVNTLTKAKTKLEQQVDDLEG-----S 1041

Query: 1591 SQQQEMAVLDRQLGHKKEE--LHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREV 1645
             +Q++   +D +   +K E  L L Q S +  + D   L E L+  E E++     I + 
Sbjct: 1042 LEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE 1101

Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
            ++L  +L  +  EL  +I E       +++EIE E  +     +Q S    EL+ I + L
Sbjct: 1102 QALAIQLQKKIKELQARIEE-------LEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154

Query: 1706 ---------QLE---NHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGE 1753
                     Q+E     E +  K++ D   S L+    A    K   +++ ++  +Q   
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELG-EQIDS 1213

Query: 1754 IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1813
            ++  KQ LE++K E++    E   L S +E +SK K + ++ C   E +L++ K      
Sbjct: 1214 LQRVKQKLEKEKSELK---MEINDLASNMETVSKAKANFEKMCRTLEDQLSEIK--TKEE 1268

Query: 1814 EENSKMEQSNLEKLELNV------RKLQQE---LDQLNRDKLSLHNDISAMQQQLQEKRE 1864
            E+   + + + +K  L+       R+L ++   + QL+R K +    I  +++QL+E+ +
Sbjct: 1269 EQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETK 1328

Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED--CQKEE 1922
            A ++L   L + +   +L ++      + +  L    ++   ++++W  ++E    Q+ E
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388

Query: 1923 ETKQ------QQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK---VTLKE 1973
            E ++      Q+LQ  +  +E    K    E   QRLQ E E     +E S    + L +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK 1448

Query: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE-----ERWCESLE--KTLSQTKRQ 2026
            +Q   +K L + K K ++  +++ A+++  R+L  E       + ESL+  +TL +  + 
Sbjct: 1449 KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKN 1508

Query: 2027 LSEREQQLVEKSG-------ELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
            L +    L E+         EL  ++K+ D  +++      +     +  E ++  ++  
Sbjct: 1509 LQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLE 1568

Query: 2080 LKIQRSQLEKNLLEQKQENSCIQKEMATI----------ELVAQDNHERARRLMK-ELNQ 2128
            L   +S++++ + E+ +E   +++    +          E+ ++++  R ++ M+ +LN+
Sbjct: 1569 LNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNE 1628

Query: 2129 MQYEYTELKKQMA--------NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLP 2180
            M+ +     +Q A         Q  L+  Q+ + DA+R  + ++K+++    +  N    
Sbjct: 1629 MEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRG-QDDLKEQLAMVERRANLMQA 1687

Query: 2181 ELPADLEAILERNEN----LEGELESLKE--NLPFTMNEGPFEEKLNFSQVHIMDEHWRG 2234
            E+  +L A LER E      E EL    E   L  T N      K    +  I       
Sbjct: 1688 EV-EELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKL-ETDISQIQGEM 1745

Query: 2235 EALREKLRHREDRLK------AQLRHCMSKQAEV---LIKGKRQTEGTLHSLRRQVDALG 2285
            E + ++ R+ E++ K      A +   + K+ +    L + K+  E T+  L+ ++D   
Sbjct: 1746 EDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE 1805

Query: 2286 ELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQEKNASA 2324
            +L     A       + +LE+ + E +S++   Q+ N  A
Sbjct: 1806 QL-----ALKGGKKQIQKLEARVRELESEVESEQKHNVEA 1840



 Score =  138 bits (348), Expect = 6e-32
 Identities = 206/954 (21%), Positives = 414/954 (43%), Gaps = 120/954 (12%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
            EE E+ + +L K   + +EL+ K    ++E KN  +L    + +A+   ++ C++L   +
Sbjct: 858  EEFEKTKEELAKTEAKRKELEEKMVTLMQE-KNDLQLQVQAEADALADAEERCDQL---I 913

Query: 329  NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
             TK +L + K  E+T   + + E+  EL   K   K E       E +E+ K  D+   +
Sbjct: 914  KTKIQL-EAKIKEVTERAEDEEEINAELTAKK--RKLE------DECSELKKDIDDLE-L 963

Query: 389  GKSRYKRNMFATESYIIDSAQAVQ-----IKKMEPDEQ-LRNDHMNLRGHTPLDTQLEDK 442
              ++ ++   ATE+ + +  + +      I K+  +++ L+  H        ++   EDK
Sbjct: 964  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME---EDK 1020

Query: 443  EKKISAAQTRLSELHDEIE---KAEQQILRATEEFKQ-LEEAIQLKKISEAGKDLLYKQL 498
               ++ A+T+L +  D++E   + E+++    E  K+ LE  ++L + S    +   +QL
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL 1080

Query: 499  SGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKS 558
            + +L+   K   E  +L+ ++E ++      QK+IK+LQ  I+ L+ +       +A ++
Sbjct: 1081 NEKLK---KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE---RASRA 1134

Query: 559  GKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK-----------DLEEQLTEGQIAAN 607
              E+Q   ++++ +++  RL+E     + + E  K           DLEE   + +  A 
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA- 1193

Query: 608  EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
             AL+K     ++ L E + +++    + + E  +L+ E   L   +  V + +   E + 
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMC 1253

Query: 668  MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE 727
               E+   +L+E+++  +EQ  +   L   +  L     E   +L+ +DA  +QL    +
Sbjct: 1254 RTLED---QLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQ 1310

Query: 728  KVTRLTQLEQSALQAELE-KERQALKNALGKA---------QFSEEKEQE---------- 767
              T+  Q+E+   Q E E K +  L +AL  A         Q+ EE+E +          
Sbjct: 1311 AFTQ--QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKA 1368

Query: 768  NSELHA-----------KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816
            NSE+             + + L++    L Q+L+D + H+  V           A +++ 
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV-------NSKCASLEKT 1421

Query: 817  RRKLKLGTGEMNIH-SPSDVLGKSLADLQKQFSEILARSKWERDEAQVR-ERKLQEEMAL 874
            +++L+    ++ I    S+    +L   Q+ F ++LA  K + +E Q   E   +E  +L
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL 1481

Query: 875  QQE--KLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN--EIHYLQENLKSMEEIQ 930
              E  K+    EE     E       N  +   +   Q  E    IH L++  K ++  +
Sbjct: 1482 STELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEK 1541

Query: 931  GLTDLQLQEAD----EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATS 986
                  L+EA+     E+ +IL    EL + K   D K  E+   LD+  +   + V + 
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESM 1601

Query: 987  DKLATAELTIAKDQL---KSLHGTVMKI-------NQERAEELQ----------EAERFS 1026
                 AE+    D L   K + G + ++       N++ AE L+          + +   
Sbjct: 1602 QSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHL 1661

Query: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETME 1085
              A +   DL    A +E   NL++ + E+ R  +E+T  G   A  ++L+  +  + + 
Sbjct: 1662 DDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLH 1721

Query: 1086 RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKR 1139
             Q T +   +  L+   S  +G  E++++E      +        + MA+  K+
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKK 1775



 Score =  130 bits (327), Expect = 2e-29
 Identities = 159/784 (20%), Positives = 343/784 (43%), Gaps = 99/784 (12%)

Query: 1578 KRAELEK----LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-----EAL 1628
            K AE EK    +K +    ++E+A  +     K++EL     +++Q K DLQ     EA 
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEA----KRKELEEKMVTLMQEKNDLQLQVQAEAD 900

Query: 1629 RLGETEVTEKCNHIREVKSLLE-------ELSFQKGELNVQISERKTQLTLIKQEIEKEE 1681
             L + E  E+C+ + + K  LE       E +  + E+N +++ +K +L     E++K+ 
Sbjct: 901  ALADAE--ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958

Query: 1682 ENLQVVLRQMSKHKTELKNILDMLQLE-----------NHELQGLKLQHDQRVSELEKTQ 1730
            ++L++ L ++ K K   +N +  L  E             E + L+  H Q + +L+  +
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE 1018

Query: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQL---LERDKREIERMTAESRALQSCVECLSK 1787
              V         L+Q     +G +E +K+L   LER KR++E    + +  Q        
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE---GDLKLAQESTMDTEN 1075

Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD-------Q 1840
            +K+ L EK    E +++  +  +   +  +   Q  +++L+  + +L++E++       +
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK 1135

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT-KHQDVLLS 1899
              + +  L  ++  + ++L+E   A ++  E     +      ++DL  +T +H+    +
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195

Query: 1900 EQTRLQKDISEWANRFEDCQKEE---ETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
             + +    ++E   + +  Q+ +   E ++ +L++  N++  N   + + +  F+++ + 
Sbjct: 1196 LRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRT 1255

Query: 1957 RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESL 2016
             E + S+++T     +E+Q +L  EL+ QK++L         + E  R L E++     L
Sbjct: 1256 LEDQLSEIKTK----EEEQQRLINELSAQKARLH------TESGEFSRQLDEKDAMVSQL 1305

Query: 2017 EKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERK--------- 2067
             +      +Q+ E ++QL E++     L     S R D  LLR Q+  E++         
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365

Query: 2068 -KAEKQVASLK-----------EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDN 2115
             KA  +VA  +           E L+  + +L + L + ++    +  + A++E   Q  
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425

Query: 2116 HERARRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKSEVKD--EIRTSL 2172
                  LM ++ +       L K+  N  K L   + +  +    L++  K+   + T L
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485

Query: 2173 KNLNQFLPELPADLEAILERNENLEGELESLKENL-------------PFTMNEGPFEEK 2219
              +     E    LE +   N+NL+ E+  L E +                ++    E +
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQ 1545

Query: 2220 LNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRR 2279
             +  +     EH  G+ LR +L    +++K+++   ++++ E L + KR     + S++ 
Sbjct: 1546 TSLEEAEASLEHEEGKILRIQL--ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQS 1603

Query: 2280 QVDA 2283
             +DA
Sbjct: 1604 TLDA 1607



 Score =  118 bits (296), Expect = 6e-26
 Identities = 155/759 (20%), Positives = 325/759 (42%), Gaps = 82/759 (10%)

Query: 1349 KRQSEKEMEELHHNIDDLLQEKKSL---ECEVEELHRTVQKRQQQKDFIDGNVESLMTEL 1405
            K++ EKE  EL   I+DL    +++   +   E++ RT++ +  +    +   + L+ EL
Sbjct: 1218 KQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINEL 1277

Query: 1406 EIEKSLKHHED-----IVDEIECIEKTLLKRRS----ELREADRLLAEAESELSCTKEKT 1456
              +K+  H E       +DE + +   L + +     ++ E  R L E E++   T    
Sbjct: 1278 SAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE-ETKAKSTLAHA 1336

Query: 1457 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA----KDLEQHK 1512
              +     D  R   + E +A+   +R    A + V   Q     + DA    ++LE+ K
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVA--QWRTKYETDAIQRTEELEEAK 1394

Query: 1513 IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA-------ERNEDHHL 1565
             K  + L++  + V A +S    L K K++L  E++ L  D+E +       ++ + +  
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454

Query: 1566 QVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ 1625
            +VL E +   +  +AELE  + +  S   E+  +        + L  L+    +   +LQ
Sbjct: 1455 KVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLK----RENKNLQ 1510

Query: 1626 EALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
            + +     ++ E   HI E++ + ++L  +K EL   + E +  L       E EE  + 
Sbjct: 1511 QEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL-------EHEEGKIL 1563

Query: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQ 1745
             +  ++++ K+E+      +  ++ EL  LK  H + V  ++ T  A +  + +   +++
Sbjct: 1564 RIQLELNQVKSEIDR---KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKK 1620

Query: 1746 ISQQQKGEIEWQKQLLERDKREIERMTAESRAL----QSCVECLSKEKEDLQE------- 1794
              +    E+E Q     R   E  R    ++ +    Q  ++   + ++DL+E       
Sbjct: 1621 KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVER 1680

Query: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISA 1854
            + ++ + ++ + +  L   E   KM +  L      V+ L  +   L   K  L  DIS 
Sbjct: 1681 RANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1740

Query: 1855 MQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
            +Q ++++       + +E  N ++    A  D          +++E+ + ++D S    R
Sbjct: 1741 IQGEMED-------IVQEARNAEEKAKKAITDA--------AMMAEELKKEQDTSAHLER 1785

Query: 1915 FEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 1974
             +   K  E   + LQ+  +E E+  LK  ++++  Q+L+      ES++E+      EQ
Sbjct: 1786 MK---KNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELESEVES------EQ 1834

Query: 1975 QHQLE--KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQ 2032
            +H +E  K L   + ++ ++  +     + +  LQ+     + L+  +   KRQ  E E+
Sbjct: 1835 KHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQD---LVDKLQTKVKAYKRQAEEAEE 1891

Query: 2033 QLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEK 2071
            Q      +   LQ E +  +    +  +Q    R K+ +
Sbjct: 1892 QSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSRE 1930



 Score =  107 bits (268), Expect = 1e-22
 Identities = 143/715 (20%), Positives = 308/715 (43%), Gaps = 108/715 (15%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM----RASKRQSEKEMEELHHNIDD-------LLQ 1368
            N E     LED +  +K+K+ E++ +     A K +   E  E    +D+       L +
Sbjct: 1248 NFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307

Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLM---------------TELEIEKSL-- 1411
             K++   ++EEL R +++  + K  +   ++S                  + E+++ +  
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367

Query: 1412 ----------KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESE---LSCTKEKTKN 1458
                      K+  D +   E +E+   K    L++A+  +    S+   L  TK++ +N
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427

Query: 1459 AVEKFT-DAKRSLLQT----------ESDAEELERRAQETAVNLVKADQQLRSLQAD--- 1504
             VE    D +RS              +    E +++ +ET   L  + ++ RSL  +   
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487

Query: 1505 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
             K+  +  +   E LK  NK +  + SD      +  K   EL+K++K ++    +E   
Sbjct: 1488 VKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD----HEKSE 1543

Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
            LQ  L+E+E  L+ +  ++ +++ ++   + E   +DR++  K EEL  L+ + ++    
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSE---IDRKIAEKDEELDQLKRNHLRVVES 1600

Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
            +Q  L   + E+  + + +R  K +   L E+  Q    N Q +E    L   +  ++  
Sbjct: 1601 MQSTL---DAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657

Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK 1737
            + +L   +R     K +L  +    +++Q E  EL+   L+  +R  ++ + ++    E+
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRA-SLERTERGRKMAEQELLDASER 1716

Query: 1738 LELENLQQISQ-QQKGEIEWQKQLLERDKREI--ERMTAESRALQSCVECLS-----KEK 1789
            ++L + Q  S    K ++E     ++ +  +I  E   AE +A ++  +        K++
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKE 1776

Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAAEENS-----KMEQSNLEKLELNVRKLQQELDQLNRD 1844
            +D     +  +K + QT + L    + +     K  +  ++KLE  VR+L+ E++   + 
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKH 1836

Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
             +                 EAV  L++    V++     ++D  +  + QD++     +L
Sbjct: 1837 NV-----------------EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV----DKL 1875

Query: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ-KERE 1958
            Q  +  +  + E+ +++      + + LQ+E+EE K +    E    +L+ K RE
Sbjct: 1876 QTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSRE 1930



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 105/542 (19%), Positives = 219/542 (40%), Gaps = 92/542 (16%)

Query: 1799 WEKKLAQTKRVLAAAEENSKME--QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
            W K   + K +L +AE   +M   +   EK +  + K + +  +L    ++L  + + +Q
Sbjct: 833  WMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ 892

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
             Q+Q + +A+   +E                       D L+  + +L+  I E   R E
Sbjct: 893  LQVQAEADALADAEERC---------------------DQLIKTKIQLEAKIKEVTERAE 931

Query: 1917 DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQH 1976
            D ++       + + L++E  E K  +   E+   +++KE+ + E+K+            
Sbjct: 932  DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV------------ 979

Query: 1977 QLEKELTDQKSKLDQVLSKVL--------AAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
               K LT++ + LD+ ++K+         A ++ +  LQ EE    +L K  ++ ++Q+ 
Sbjct: 980  ---KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036

Query: 2029 EREQQLVEKSGELLALQKEADSMRADFSLLRNQFL-TERKKAEKQVASLKEALKIQRSQL 2087
            + E  L ++    + L++    +  D  L +   + TE  K +     L E LK +    
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ-----LNEKLKKK---- 1087

Query: 2088 EKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE 2147
                          + EM+ ++   +D    A +L K++ ++Q    EL++         
Sbjct: 1088 --------------EFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE--------- 1124

Query: 2148 RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKEN- 2206
              ++E   A R    + + ++   L+ +++ L E      A +E N+  E E + ++ + 
Sbjct: 1125 --EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182

Query: 2207 ----LPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEV 2262
                L          +K   S   + ++    + +++KL   +  LK ++   ++   E 
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIND-LASNMET 1241

Query: 2263 LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSL-TEDSQLG-QNQEK 2320
            + K K   E    +L    D L E+ T           LS  ++ L TE  +   Q  EK
Sbjct: 1242 VSKAKANFEKMCRTLE---DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298

Query: 2321 NA 2322
            +A
Sbjct: 1299 DA 1300



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 112/518 (21%), Positives = 227/518 (43%), Gaps = 65/518 (12%)

Query: 650  LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAY-EAEL 708
            L +  E E+E   ++    + E  ++ELA+ E+  +E  E   +L Q + DL    +AE 
Sbjct: 843  LLKSAETEKEMANMK---EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEA 899

Query: 709  EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQEN 768
            +A   L DAE            R  QL ++ +Q E +     +K    +A   E++E+ N
Sbjct: 900  DA---LADAEE-----------RCDQLIKTKIQLEAK-----IKEVTERA---EDEEEIN 937

Query: 769  SELHAKLKHLQDDNNLLKQQLKDFQNHL------NHVVDGLVR--PEEVAARVDELRRKL 820
            +EL AK + L+D+ + LK+ + D +  L       H  +  V+   EE+A   + + +  
Sbjct: 938  AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 997

Query: 821  KLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK-- 878
            K        H       ++L DLQ +  ++   +K    + ++ ++    E +L+QEK  
Sbjct: 998  KEKKALQEAHQ------QTLDDLQMEEDKVNTLTK---AKTKLEQQVDDLEGSLEQEKKL 1048

Query: 879  ---LATGQEEFRQACERALEARMNF--DKRQHEARIQQMENEIHYLQENLKSMEEIQGLT 933
               L   + +     + A E+ M+   DK+Q   ++++ E E+  LQ  +   E+ Q L 
Sbjct: 1049 CMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI---EDEQALA 1105

Query: 934  DLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAE 993
             +QLQ+  +E +  + +L E  + ++   AK+++Q   L +EL+++ + +  +    +A+
Sbjct: 1106 -IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164

Query: 994  LTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
            + + K +          + +   +    A    +K A +  +L      ++ ++  L ++
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224

Query: 1054 GEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEI-------ARLQNVLDLTGS-- 1103
              + ++E+          S+     EK+  T+E Q +EI        RL N L    +  
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284

Query: 1104 -DNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140
                G F   L+E   +  ++S      +   +  KR+
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 131/625 (20%), Positives = 253/625 (40%), Gaps = 64/625 (10%)

Query: 232  TLPHYLQFTIFHLRSL-ESLEGQPVTTQDRQEAFERFSLEEVE---RLERDLEKKMIETE 287
            TL H LQ        L E  E +     + Q    + + E  +   + E D  ++  E E
Sbjct: 1332 TLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391

Query: 288  ELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ 347
            E K K  + L++ +   +   S        KQ  +    DL    E      I L +   
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK--- 1448

Query: 348  KQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDS 407
            KQ   ++ LA +K          Y    AE++ +  ES  +    +K      ES     
Sbjct: 1449 KQRNFDKVLAEWK--------QKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLE 1500

Query: 408  AQAVQIKKMEPD-----EQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEK 462
                + K ++ +     EQ+     ++     +  QL+ ++ ++   QT L E    +E 
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSEL---QTSLEEAEASLEH 1557

Query: 463  AEQQILRATEEFKQL------------EEAIQLKK----ISEAGKDLLYKQLSGR---LQ 503
             E +ILR   E  Q+            EE  QLK+    + E+ +  L  ++  R   L+
Sbjct: 1558 EEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALR 1617

Query: 504  LVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS----LDSKDPKHSHMKAQKSG 559
            +  K+  +  ++E+Q+    ++ A   + +++ Q  +      LD        +K Q + 
Sbjct: 1618 IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAM 1677

Query: 560  KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE--QLTEGQIAANEALKKDLEGV 617
             E++ ++M  + ++L + L+          +E+ D  E  QL   Q  +    KK LE  
Sbjct: 1678 VERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737

Query: 618  ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
            IS +Q  +  I  +A  A+ + +K   +   + +   E+++E+D    +    +NM + +
Sbjct: 1738 ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAE---ELKKEQDTSAHLERMKKNMEQTV 1794

Query: 678  AELESALQEQHEV-----NASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRL 732
             +L+  L E  ++        +Q+ +  +   E+E+E+           L++   +V  L
Sbjct: 1795 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKEL 1854

Query: 733  T-QLEQ---SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQ 788
            T Q E+   + L+ +   ++   K    K Q  E +EQ N  L AK + LQ +    K++
Sbjct: 1855 TYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL-AKFRKLQHELEEAKER 1913

Query: 789  LKDFQNHLNHVVDGLVRPEEVAARV 813
                ++ +N +    V+  EV  +V
Sbjct: 1914 ADIAESQVNKL---RVKSREVHTKV 1935



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 77/369 (20%), Positives = 159/369 (43%), Gaps = 46/369 (12%)

Query: 128  EVLNLSYNLIGKIEKLDKLL--KLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIP 185
            E+  L  N +  +E +   L  ++R  N +     K+EG  N   +Q        + H  
Sbjct: 1586 ELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ--------LNHAN 1637

Query: 186  VWLGKKLKSLRVLNLKGN-KISSLQDISKLKPLQDLIS-LILVENPVVTLPHYLQFTIFH 243
                + L++LR  N +G  K + L     ++   DL   L +VE       + +Q  +  
Sbjct: 1638 RQAAEALRNLR--NTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRA----NLMQAEVEE 1691

Query: 244  LR-SLESLE-GQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETE--ELKSKQTRFLEE 299
            LR SLE  E G+ +  Q+  +A ER  L   +       KK +ET+  +++ +    ++E
Sbjct: 1692 LRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQE 1751

Query: 300  IKN-QDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL--LKQKTIELTRACQKQYELEQEL 356
             +N ++K  K++ + AM+     EELK + +T   L  +K+   +  +  Q + +  ++L
Sbjct: 1752 ARNAEEKAKKAITDAAMM----AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL 1807

Query: 357  AF-------YKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESY------ 403
            A         K++A+   L        + +    +     + R K   + TE        
Sbjct: 1808 ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILR 1867

Query: 404  ---IIDSAQA-VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDE 459
               ++D  Q  V+  K + +E     ++NL     L  +LE+ +++   A++++++L  +
Sbjct: 1868 LQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVK 1927

Query: 460  IEKAEQQIL 468
              +   +++
Sbjct: 1928 SREVHTKVI 1936



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 46/218 (21%), Positives = 100/218 (45%), Gaps = 34/218 (15%)

Query: 1321 LENEVSRL----EDIMQHLKSKKREERW------MRASKRQSEKE----MEELHHNIDDL 1366
            LE ++S++    EDI+Q  ++ + + +       M A + + E++    +E +  N++  
Sbjct: 1734 LETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1793

Query: 1367 LQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI----- 1421
            +++ +    E E+L     K+Q QK  ++  V  L  E E+E   KH+ + V  +     
Sbjct: 1794 VKDLQLRLDEAEQLALKGGKKQIQK--LEARVREL--ESEVESEQKHNVEAVKGLRKHER 1849

Query: 1422 ---ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE 1478
               E   +T   R++ LR  D L+ + ++++   K + + A E+         + + + E
Sbjct: 1850 RVKELTYQTEEDRKNILRLQD-LVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908

Query: 1479 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
            E + RA         A+ Q+  L+  ++++    I +E
Sbjct: 1909 EAKERAD-------IAESQVNKLRVKSREVHTKVISEE 1939


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  169 bits (428), Expect = 3e-41
 Identities = 216/1065 (20%), Positives = 468/1065 (43%), Gaps = 120/1065 (11%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ + L+ ++     + A KR+ E E  EL  +IDDL      +E E       V+
Sbjct: 919  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE-------KTLLKRRSELRE 1437
               ++   +D  +  L  E   +K+L+  H+  +D+++  E       K+ +K   ++ +
Sbjct: 979  NLTEEMAGLDEIIAKLTKE---KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDD 1035

Query: 1438 ADRLLAEAESELSCTKEKTKNAVE---KFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
             +  L E E ++    E+ K  +E   K T  + S++  E+D  +LE + ++   ++ + 
Sbjct: 1036 LEGSL-EQEKKVRMDLERAKRKLEGDLKLT--QESIMDLENDKLQLEEKLKKKEFDINQQ 1092

Query: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI 1554
            + ++   Q  A  L++   + +  ++E+ + + A+ +    + K +  L+ EL+++ + +
Sbjct: 1093 NSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152

Query: 1555 EMAERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQ 1592
            E A       +++ K+ E   Q  R +LE+                      L  Q+ + 
Sbjct: 1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1212

Query: 1593 QQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649
            Q+    L+++    K EL  +  +M   ++AKA+L++  R  E +  E    + E +  L
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272

Query: 1650 EELSFQK-------GELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
             + + Q+       GEL  Q+ E++   +QLT  K    ++ E+L+  L +  K K  L 
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332

Query: 1700 NILDMLQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQ 1750
            + L   Q   H+   L+ Q++         QRV     ++VA    K E + +Q+  + +
Sbjct: 1333 HAL---QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1389

Query: 1751 KGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD-------IWEKKL 1803
            + + +  ++L + ++  +E + A+  +L+     L  E EDL    +         +KK 
Sbjct: 1390 EAKKKLAQRLQDAEEA-VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448

Query: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
                ++LA  ++  +  QS LE  +   R L  EL         L N      + L+  +
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTEL-------FKLKNAYEESLEHLETFK 1501

Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
                +LQEE++++ + L    +++    K +  L  E+  LQ  + E          E  
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE---------AEAS 1552

Query: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV-----TLKEQQHQL 1978
             + ++ ++L+ ++E N++K    E+  +  +K+ E E++K    +V     T  + + + 
Sbjct: 1553 LEHEEGKILRAQLEFNQIKA---EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609

Query: 1979 EKELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
              E+   K K++  L+++ +      R   E ++  +SL+  L  T+ QL +  +   + 
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669

Query: 2038 SGELLALQKEADSMRADFSLLR---NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ 2094
               +  +++  + ++A+   LR    Q    RK AE+++    E +++  SQ    + ++
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729

Query: 2095 KQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
            K+  S + +  + +E   Q+      +  K +        ELKK+      LER +  + 
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789

Query: 2155 DAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEG 2214
              ++ L+  + +  + +LK   + L +L A       R   LEGELE+ ++    ++ +G
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEA-------RVRELEGELEAEQKRNAESV-KG 1841

Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
              + +    ++    E  +   LR  L+   D+L+ +++    +QAE   + + Q    L
Sbjct: 1842 MRKSERRIKELTYQTEEDKKNLLR--LQDLVDKLQLKVK-AYKRQAE---EAEEQANTNL 1895

Query: 2275 HSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQE 2319
               R+    L E      A+  +  + SQ+     +   +G  Q+
Sbjct: 1896 SKFRKVQHELDE------AEERADIAESQVNKLRAKSRDIGAKQK 1934



 Score =  157 bits (398), Expect = 9e-38
 Identities = 218/1025 (21%), Positives = 445/1025 (43%), Gaps = 122/1025 (11%)

Query: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
            ++ L+   E EK +     + +E   I++TL K  +  +E +  +     E +  + + +
Sbjct: 838  IKPLLKSAETEKEMA---TMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894

Query: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
               +   DA+    Q   +  +LE + +E    L   ++    L A  + LE    + ++
Sbjct: 895  AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK 954

Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEE----------LQKLQKDIEMAERNEDHHLQV 1567
             + ++   +A  + +      K + LTEE          L K +K ++ A +     LQV
Sbjct: 955  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQV 1014

Query: 1568 LKESEVLLQAKRAELEK----LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
             ++    L   + +LE+    L+  +  +++    L+R     + +L L Q S++  + D
Sbjct: 1015 EEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1074

Query: 1624 ---LQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQL---TLIKQEI 1677
               L+E L+  E ++ ++ + I + + L  +L  +  E   +I E + +L      + ++
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134

Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDM-----------LQLENHELQGLKLQHDQRVSEL 1726
            EK   +L   L ++S+   E      +            Q    +L+   LQH+   + L
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194

Query: 1727 EKTQV-AVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECL 1785
             K    +V E   +++NLQ++ Q+ + E           K E++ +T+    +      L
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKE-------KSEFKLELDDVTSNMEQIIKAKANL 1247

Query: 1786 SKEKEDLQEKCDIWEKKLAQTKRVL-AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
             K    L+++ + +  KL + +R L     + +K++  N E L   + + +  + QL R 
Sbjct: 1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE-LARQLEEKEALISQLTRG 1306

Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
            KLS    +  +++QL+E+ +A N+L   L + +   +L ++     T+ +  L    ++ 
Sbjct: 1307 KLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1366

Query: 1905 QKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
              ++++W  ++E    Q+ EE ++      Q+LQ  +  +E    K    E    RLQ E
Sbjct: 1367 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426

Query: 1957 RESEESKLETSK---VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE---- 2009
             E     +E S      L ++Q   +K L + K K ++  S++ ++++  R+L  E    
Sbjct: 1427 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486

Query: 2010 -ERWCESLE--KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 2066
               + ESLE  +T  +  + L E    L E+ GE      E + +R    + + +  +  
Sbjct: 1487 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSAL 1546

Query: 2067 KKAEKQVASLK-EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA------ 2119
            ++AE   ASL+ E  KI R+QLE N ++ + E    +K+    +  A+ NH+R       
Sbjct: 1547 EEAE---ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ--AKRNHQRVVDSLQT 1601

Query: 2120 ----------------RRLMKELNQMQYEYT-------ELKKQMAN-QKDLERRQMEISD 2155
                            +++  +LN+M+ + +       E +KQ+ + Q  L+  Q+++ D
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661

Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NLPF 2209
            A+R    ++K+ I    +  N    EL  +L A++E+ E      E EL    E   L  
Sbjct: 1662 AVRA-NDDLKENIAIVERRNNLLQAEL-EELRAVVEQTERSRKLAEQELIETSERVQLLH 1719

Query: 2210 TMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAEV- 2262
            + N     +K          +    EA++E  R+ E++ K      A +   + K+ +  
Sbjct: 1720 SQNTSLINQKKKMESDLTQLQSEVEEAVQE-CRNAEEKAKKAITDAAMMAEELKKEQDTS 1778

Query: 2263 --LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQE 2319
              L + K+  E T+  L+ ++D   ++     A       L +LE+ + E + +L   Q+
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQI-----ALKGGKKQLQKLEARVRELEGELEAEQK 1833

Query: 2320 KNASA 2324
            +NA +
Sbjct: 1834 RNAES 1838



 Score =  140 bits (354), Expect = 1e-32
 Identities = 178/843 (21%), Positives = 371/843 (44%), Gaps = 105/843 (12%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDL-------LQEKKSL 1373
            L+   +R+E++ + L++++     +   +    +E+EE+   +++        ++  K  
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1169

Query: 1374 ECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSLKHHE 1415
            E E +++ R +++            R++  D +        N++ +  +LE EKS    E
Sbjct: 1170 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1229

Query: 1416 DIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTES 1475
              +D++    + ++K ++ L +  R L +  +E     E+ + ++  FT  +R+ LQTE+
Sbjct: 1230 --LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT-TQRAKLQTEN 1286

Query: 1476 DAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS---D 1532
               EL R+ +E    +    Q  R   +  + +E  K + EE  K  N +  A  S   D
Sbjct: 1287 G--ELARQLEEKEALI---SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHD 1341

Query: 1533 FQCLSKKKEKLTEELQKLQK-----DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKS 1587
               L ++ E+ TE   +LQ+     + E+A+    +    ++ +E L +AK+    KL  
Sbjct: 1342 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK----KLAQ 1397

Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH---IRE 1644
            ++   ++ +  ++ +    ++  H LQ  +     D++ +         ++ N    + E
Sbjct: 1398 RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1457

Query: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDM 1704
             K   EE   +      +     T+L  +K   E+  E+L+   R+    + E+ ++ + 
Sbjct: 1458 WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517

Query: 1705 L---QLENHELQGLKLQHD----QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757
            L       HEL+ ++ Q +    +  S LE+ + ++  E+ ++   Q    Q K EIE  
Sbjct: 1518 LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-- 1575

Query: 1758 KQLLERD------KREIER--------MTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
            ++L E+D      KR  +R        + AE+R+    +    K + DL E     E +L
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNE----MEIQL 1631

Query: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
            +   R+ A A++  K  QS L+  ++ +    +  D L  +   +    + +Q +L+E R
Sbjct: 1632 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1691

Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
              V   +           LA+Q+L+ T++   +L S+ T L     +  +     Q E E
Sbjct: 1692 AVVEQTERS-------RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVE 1744

Query: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSKVTLKEQQHQLEK 1980
               + +Q  +N  E+ K  +    MM + L+KE+++    E   +  + T+K+ QH+L++
Sbjct: 1745 ---EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801

Query: 1981 ----ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVE 2036
                 L   K +L ++ ++V   E  +    E++R  ES+ K + +++R++ E   Q  E
Sbjct: 1802 AEQIALKGGKKQLQKLEARVRELEGELEA--EQKRNAESV-KGMRKSERRIKELTYQTEE 1858

Query: 2037 KSGELLALQKEADSMRADFSLLRNQF----------LTERKKAEKQVASLKEALKIQRSQ 2086
                LL LQ   D ++      + Q           L++ +K + ++   +E   I  SQ
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1918

Query: 2087 LEK 2089
            + K
Sbjct: 1919 VNK 1921



 Score =  117 bits (294), Expect = 1e-25
 Identities = 194/908 (21%), Positives = 406/908 (44%), Gaps = 116/908 (12%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
            EE  R++  LEK     +EL+ K    L+E KN  +L    +++ +   ++ C++L    
Sbjct: 856  EEFGRIKETLEKSEARRKELEEKMVSLLQE-KNDLQLQVQAEQDNLNDAEERCDQL---- 910

Query: 329  NTKNEL-LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
              KN++ L+ K  E+    + + E+  EL   K   K E       E +E+ K  D+   
Sbjct: 911  -IKNKIQLEAKVKEMNERLEDEEEMNAELTAKK--RKLE------DECSELKKDIDDLE- 960

Query: 388  IGKSRYKRNMFATESYIIDSAQAVQ-----IKKMEPDEQ-LRNDHMNLRGHTPLDTQLED 441
            +  ++ ++   ATE+ + +  + +      I K+  +++ L+  H        ++   ED
Sbjct: 961  LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE---ED 1017

Query: 442  KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLS 499
            K   +S ++ +L +  D++E + +Q  +   + ++ +  ++  LK   E+  DL     +
Sbjct: 1018 KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL----EN 1073

Query: 500  GRLQLVNKLRQEALDLELQMEKQKQE---IAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
             +LQL  KL+++  D+  Q  K + E       QK++K+ Q  I+ L+ +      ++A+
Sbjct: 1074 DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE------LEAE 1127

Query: 557  KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEG 616
            ++ + +    + K    L   L+EI  R+ +E      ++ ++ + + A  + +++DLE 
Sbjct: 1128 RTARAK----VEKLRSDLSRELEEISERL-EEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182

Query: 617  VISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE-RDQLEIVAMDAENMRK 675
                 +     ++ +   +  E  +  D  + + Q+L + + E + +L+ V  + E + K
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242

Query: 676  ELAELES---ALQEQ-HEVNASLQQTQGDLSAYEAELEARLNLRDAE-ANQLKEELEKVT 730
              A LE     L++Q +E    L++ Q  L+ +  +  A+L   + E A QL+E+   ++
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAKLQTENGELARQLEEKEALIS 1301

Query: 731  RLTQ------LEQSALQAELEKERQALKNALGKAQFS--------EEKEQENSELHAKLK 776
            +LT+       +   L+ +LE+E +A KNAL  A  S         E+ +E +E  A+L+
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEEGKA-KNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360

Query: 777  HLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN-IHSPSDV 835
             +     L K   +  Q    +  D + R EE+     +L ++L+     +  +++    
Sbjct: 1361 RV-----LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415

Query: 836  LGKSLADLQKQFSEILA---RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR--QAC 890
            L K+   LQ +  +++    RS         ++R   + +A  ++K    Q E    Q  
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475

Query: 891  ERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE-----EKE 945
             R+L   +   K  +E  ++ +E    + +EN    EEI  LT+ QL E  +     EK 
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLET---FKRENKNLQEEISDLTE-QLGEGGKNVHELEKV 1531

Query: 946  RILAQLRELEKKKKLEDAKS-----QEQVFGLDKELKKLKKAVATSDKLATAELTIAK-- 998
            R   ++ +LE +  LE+A++     + ++     E  ++K  +         E+  AK  
Sbjct: 1532 RKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1591

Query: 999  -----DQLKS-------LHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELL 1046
                 D L++           V+++ ++   +L E E    + + A R    A+ +++ L
Sbjct: 1592 HQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME---IQLSHANRMAAEAQKQVKSL 1648

Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNK 1106
            Q+LL  K  Q +L+ +           +  +E+ N  ++    E+  L+ V++ T    K
Sbjct: 1649 QSLL--KDTQIQLD-DAVRANDDLKENIAIVERRNNLLQ---AELEELRAVVEQTERSRK 1702

Query: 1107 GGFENVLE 1114
               + ++E
Sbjct: 1703 LAEQELIE 1710



 Score =  106 bits (265), Expect = 2e-22
 Identities = 187/904 (20%), Positives = 380/904 (42%), Gaps = 129/904 (14%)

Query: 273  ERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKN 332
            ER ++ ++ K+    +L++K     E +++++++N  L  +    +  C ELK D++   
Sbjct: 905  ERCDQLIKNKI----QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE 960

Query: 333  ELLKQKTIELTRACQKQYELEQELA-----FYKIDAKFEPL-NYYPSEYAEIDKAPDESP 386
              L +   E      K   L +E+A       K+  + + L   +     ++    D+  
Sbjct: 961  LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN 1020

Query: 387  YIGKSRYKRNMFATE-SYIIDSAQAVQI------KKMEPDEQLRNDH-MNLRG-HTPLDT 437
             + KS+ K      +    ++  + V++      +K+E D +L  +  M+L      L+ 
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080

Query: 438  QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
            +L+ KE  I+   +++ +      + ++++       ++LEE ++ ++ + A  + L   
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140

Query: 498  LSGRLQLVNKLRQEALD-LELQMEKQKQEIAGKQKEIKDLQIAI----DSLDSKDPKHSH 552
            LS  L+ +++  +EA     +Q+E  K+  A  QK  +DL+ A      +  +   KH+ 
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200

Query: 553  MKAQKSGKEQQLDIMNKQYQQLES-------RLDEILSRIAKETEEIKDLEEQLTEGQIA 605
              A+     +Q+D + +  Q+LE         LD++ S + +  +   +LE+     +  
Sbjct: 1201 SVAELG---EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQ 1257

Query: 606  ANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT----------- 654
            ANE   K LE     L ++  T + +      E  +  +EKE L+ +LT           
Sbjct: 1258 ANEYRVK-LEEAQRSLNDFT-TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQME 1315

Query: 655  ----EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEA 710
                ++E+E      +A   ++ R +   L    +E+ E  A LQ+    LS   +E+  
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSEVAQ 1372

Query: 711  RLNLRDAEANQLKEELEKV-TRLTQLEQSALQA---------ELEKERQALKN------- 753
                 + +A Q  EELE+   +L Q  Q A +A          LEK +  L+N       
Sbjct: 1373 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV 1432

Query: 754  ----------ALGK---------AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQN 794
                      AL K         A++ ++ E+  SEL +  K  +  +  L +    ++ 
Sbjct: 1433 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1492

Query: 795  HLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV---LGKSLADLQKQFSEIL 851
             L H+       + +   + +L    +LG G  N+H    V   L     +LQ    E  
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTE--QLGEGGKNVHELEKVRKQLEVEKLELQSALEE-- 1548

Query: 852  ARSKWERDEAQVRERKLQ--EEMALQQEKLATGQEEFRQACER------ALEARMNFD-- 901
            A +  E +E ++   +L+  +  A  + KLA   EE  QA         +L+  ++ +  
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608

Query: 902  --------KRQHEARIQQMENEIHY-------LQENLKSMEEIQGLTDLQLQEADEEKER 946
                    K++ E  + +ME ++ +        Q+ +KS++ +   T +QL +A    + 
Sbjct: 1609 SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668

Query: 947  ILAQLRELEKKKKLEDAKSQE--QVFGLDKELKKL--KKAVATSDK--LATAELTIAKDQ 1000
            +   +  +E++  L  A+ +E   V    +  +KL  ++ + TS++  L  ++ T   +Q
Sbjct: 1669 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1728

Query: 1001 LKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLE 1060
             K +   + ++  E  E +QE      KA +A  D      E++  Q+      E+ +  
Sbjct: 1729 KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKN 1787

Query: 1061 MEKT 1064
            ME+T
Sbjct: 1788 MEQT 1791



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 120/571 (21%), Positives = 245/571 (42%), Gaps = 56/571 (9%)

Query: 549  KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
            K +  + + +  +++   + +  ++ E+R  E+  ++    +E  DL+ Q+   Q   N+
Sbjct: 843  KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902

Query: 609  ALKK---------DLEGVISGLQEYL-------GTIKGQATQAQNECRKLRDEKETLLQR 652
            A ++          LE  +  + E L         +  +  + ++EC +L+ + + L   
Sbjct: 903  AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962

Query: 653  LTEVEQERDQLEIVAMDAENMRKELAELESAL----QEQHEVNASLQQTQGDLSAYEAEL 708
            L +VE+E+   E      +N+ +E+A L+  +    +E+  +  + QQ   DL   E ++
Sbjct: 963  LAKVEKEKHATE---NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKV 1019

Query: 709  EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFS-EEKEQE 767
             + L+    +  Q  ++LE        ++  ++ +LE+ ++ L+  L   Q S  + E +
Sbjct: 1020 NS-LSKSKVKLEQQVDDLEGSLE----QEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1074

Query: 768  NSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKL-GTGE 826
              +L  KLK  + D N    +++D Q     +   L   +E  AR++EL  +L+   T  
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL---KENQARIEELEEELEAERTAR 1131

Query: 827  MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
              +      L + L ++ ++  E    +  + +  + RE + Q+     +E  AT Q E 
Sbjct: 1132 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE--ATLQHEA 1189

Query: 887  RQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKER 946
              A  R          ++H   + ++  +I  LQ   + +E+ +    L+L +     E+
Sbjct: 1190 TAAALR----------KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239

Query: 947  ILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
            I+     LEK  +  + ++ E    L++  + L        KL T    +A+ QL+    
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELAR-QLEEKEA 1298

Query: 1007 TVMKINQERAEELQEAERFSR------KAAQA-ARDLTRAEAEIELLQNLLRQKGEQFRL 1059
             + ++ + +    Q+ E   R      KA  A A  L  A  + +LL+    Q  E+   
Sbjct: 1299 LISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR---EQYEEETEA 1355

Query: 1060 EMEKTGVGTGANSQVLEIEKLNETMERQRTE 1090
            + E   V + ANS+V +     ET   QRTE
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 126/575 (21%), Positives = 246/575 (42%), Gaps = 105/575 (18%)

Query: 613  DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE----VEQERDQLEIVAM 668
            + E  ++ ++E  G IK    +++   ++L ++  +LLQ   +    V+ E+D L     
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905

Query: 669  DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE-----ARLNLRDAEANQLK 723
              + + K   +LE+ ++E +E     ++   +L+A + +LE      + ++ D E    K
Sbjct: 906  RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965

Query: 724  EELEK------VTRLTQLEQSALQ---AELEKERQALKNALGKA--QFSEEKEQENSELH 772
             E EK      V  LT+ E + L    A+L KE++AL+ A  +A      E+++ NS   
Sbjct: 966  VEKEKHATENKVKNLTE-EMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024

Query: 773  AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSP 832
            +K+K        L+QQ+ D +  L          +E   R+D  R K KL  G++ +   
Sbjct: 1025 SKVK--------LEQQVDDLEGSLE---------QEKKVRMDLERAKRKL-EGDLKLTQ- 1065

Query: 833  SDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACER 892
                 +S+ DL+                      KLQ E  L++++    Q+  +   E+
Sbjct: 1066 -----ESIMDLEND--------------------KLQLEEKLKKKEFDINQQNSKIEDEQ 1100

Query: 893  ALEARMNFDKRQHEARIQQMENEI------------------HYLQENLKSMEEIQGLTD 934
             L  ++    ++++ARI+++E E+                    L+E  + +EE  G T 
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160

Query: 935  LQLQEADEEKERILAQLRELEK------------KKKLEDAKSQ--EQVFGLDKELKKLK 980
            +Q++   + +       R+LE+            +KK  D+ ++  EQ+  L +  +KL+
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220

Query: 981  KAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE 1040
            K   +  KL   ++T   +Q+      + K+++   ++  E      +A ++  D T   
Sbjct: 1221 KE-KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279

Query: 1041 AEIELLQ-NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
            A+++     L RQ  E+  L  + T    G  S   ++E L   +E +      L + L 
Sbjct: 1280 AKLQTENGELARQLEEKEALISQLT---RGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336

Query: 1100 LTGSD---NKGGFENVLEEIAELRREVSYQNDYIS 1131
                D    +  +E   E  AEL+R +S  N  ++
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 115/590 (19%), Positives = 253/590 (42%), Gaps = 88/590 (14%)

Query: 258  QDRQEAFERF-----SLEEVE-RLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLK 311
            QD +EA E       SLE+ + RL+ ++E  M++ E   +      ++ +N DK+   L 
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI---LA 1456

Query: 312  EEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYY 371
            E     KQ  EE +S+L +  +  +  + EL +      E  + L  +K + K       
Sbjct: 1457 E----WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK------- 1505

Query: 372  PSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRG 431
             +   EI    ++    GK+ ++      +         ++++K+E    L         
Sbjct: 1506 -NLQEEISDLTEQLGEGGKNVHELEKVRKQ---------LEVEKLELQSALEE------- 1548

Query: 432  HTPLDTQLEDKEKKISAAQTRLSELHDEIEKA----EQQILRATEEFKQLEEAIQLKKIS 487
                +  LE +E KI  AQ   +++  EIE+     ++++ +A    +++ +++Q    +
Sbjct: 1549 ---AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDA 1605

Query: 488  EAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKD 547
            E       +  +  L++  K+  +  ++E+Q+    +  A  QK++K LQ  +   D++ 
Sbjct: 1606 ET------RSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK--DTQI 1657

Query: 548  PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
                 ++A    KE  + I+ ++   L++ L+E L  + ++TE  + L EQ         
Sbjct: 1658 QLDDAVRANDDLKEN-IAIVERRNNLLQAELEE-LRAVVEQTERSRKLAEQ--------- 1706

Query: 608  EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
                      +    E +  +  Q T   N+ +K+  +   L Q  +EVE+   +     
Sbjct: 1707 ---------ELIETSERVQLLHSQNTSLINQKKKMESD---LTQLQSEVEEAVQECRNAE 1754

Query: 668  MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQL----- 722
              A+    + A +   L+++ + +A L++ + ++     +L+ RL+    EA Q+     
Sbjct: 1755 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD----EAEQIALKGG 1810

Query: 723  KEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
            K++L+K+    +  +  L+AE ++  +++K      +  +E   +  E    L  LQD  
Sbjct: 1811 KKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLV 1870

Query: 783  NLLKQQLKDFQNHLNHVVD----GLVRPEEVAARVDELRRKLKLGTGEMN 828
            + L+ ++K ++       +     L +  +V   +DE   +  +   ++N
Sbjct: 1871 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 101/503 (20%), Positives = 218/503 (43%), Gaps = 91/503 (18%)

Query: 268  SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEE-AMLQKQSCEELKS 326
            S  E+E  +++      E  +LK+     LE ++   + NK+L+EE + L +Q  E  K+
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524

Query: 327  --DLNTKNELLKQKTIELTRACQK-----QYE----LEQELAFYKIDAKFEPLNYYPSEY 375
              +L    + L+ + +EL  A ++     ++E    L  +L F +I A+ E       + 
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE------RKL 1578

Query: 376  AEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH--- 432
            AE D+  +++        KRN       ++DS Q      ++ + + RN+ + ++     
Sbjct: 1579 AEKDEEMEQA--------KRN----HQRVVDSLQT----SLDAETRSRNEVLRVKKKMEG 1622

Query: 433  --TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI---LRATEEFK------------ 475
                ++ QL    +  + AQ ++  L   ++  + Q+   +RA ++ K            
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682

Query: 476  ---QLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKE 532
               +LEE   + + +E  + L  ++L    + V  L  +   L  Q +K + ++   Q E
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742

Query: 533  IKDLQIAIDSLDSKDPK---HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
            +++      + + K  K    + M A++  KEQ                   L R+ K  
Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH--------------LERMKKNM 1788

Query: 590  EE-IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
            E+ IKDL+ +L E +  A +  KK L+ + + ++E  G ++ +  +     + +R  +  
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848

Query: 649  LLQRLTEVEQER-------DQLEIVAMDAENMRKELAELESALQEQHEVNAS-LQQTQGD 700
            + +   + E+++       D ++ + +  +  +++  E E    EQ   N S  ++ Q +
Sbjct: 1849 IKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAE----EQANTNLSKFRKVQHE 1904

Query: 701  LSAYEAELEARLNLRDAEANQLK 723
            L     E E R ++ +++ N+L+
Sbjct: 1905 LD----EAEERADIAESQVNKLR 1923


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  168 bits (425), Expect = 6e-41
 Identities = 201/944 (21%), Positives = 415/944 (43%), Gaps = 97/944 (10%)

Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL-------QEKKSLECEVEE 1379
            +++++ + L+ ++     + A +R+ E E  EL  +IDDL        +EK++ E +V+ 
Sbjct: 967  KVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKN 1026

Query: 1380 L-------HRTVQKRQQQKDFIDGNVESLMTELEIE--------KSLKHHEDIVDEIECI 1424
            L         +V +  ++K  +    +  + +L+ E        K+    E  V+++EC 
Sbjct: 1027 LTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECS 1086

Query: 1425 EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
             +   K R +   A R L   E +L  T+E   +A +     +  L + +S+  +L  R 
Sbjct: 1087 LEQEKKLRMDTERAKRKL---EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRV 1143

Query: 1485 QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE--- 1541
            ++  +   +  ++++ LQA A++LE+    +      + K  A    + + LS++ E   
Sbjct: 1144 EDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAG 1203

Query: 1542 -----------KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590
                       K   EL +L++++E A    +  +  L+      QA+ A   +L  QV 
Sbjct: 1204 GASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRK----QAEGAA--ELGEQVD 1257

Query: 1591 SQQQEMAVLDRQLGHKKEELHLLQGS---MVQAKADLQEALRLGETEVTEKCNHIREVKS 1647
            S Q+    L+++    + E+  L  +   + +AKA  ++  R  E +++E    + E++ 
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQR 1317

Query: 1648 LLEELSFQKGELNVQISERK----------TQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
             L + S Q+G L  +  E            +QL+  K    +  E L+  L + SK K+ 
Sbjct: 1318 QLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSA 1377

Query: 1698 LKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757
            L + +  L+   H+   L+ QH++      + ++  L  K   E  Q  S+ +   I+  
Sbjct: 1378 LAHAVQALR---HDCDLLREQHEEEAEA--QAELQRLLSKANAEVAQWRSKYEADAIQRT 1432

Query: 1758 KQLLERDKREIERMTAESRALQSC-VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEEN 1816
            ++L E  K+   R+      +++   +C S EK  L+ + +  +  L   +   AAA  +
Sbjct: 1433 EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALD 1492

Query: 1817 SKME--QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSL----- 1869
             K    +  LE+      ++Q+EL+   R+   L  ++  ++   +E  EA+ +L     
Sbjct: 1493 KKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENK 1552

Query: 1870 --QEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQ 1927
              QEE++++ D ++L+ + +    K +  L  E++ +Q  + E     E   +E +T + 
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE--LEETKTLRI 1610

Query: 1928 QLQVLQNEIE-ENKLKLVQQEMMFQRLQKER--ESEESKLETSKVTLKEQ---QHQLEKE 1981
            QL++ Q + E + KL    +E    R   +R  ES ++ L+       E    + ++E +
Sbjct: 1611 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 1670

Query: 1982 LTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGEL 2041
            L D + +L     +   A+   R +Q +          L + +    E ++   E   + 
Sbjct: 1671 LNDLELQLGHATRQATEAQAATRLMQAQ----------LKEEQAGRDEEQRLAAELHEQA 1720

Query: 2042 LALQKEADSMRADFSLLR---NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
             AL++ A  + A+   LR    Q    R+ AE+++    E L +  SQ    L ++K+  
Sbjct: 1721 QALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1780

Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMR 2158
            + + +    +E  AQ+  E   +  K +        ELKK+      LER +  +   +R
Sbjct: 1781 ADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVR 1840

Query: 2159 TLKSEVKDEIRTSLKNLNQFLPELPA---DLEAILERNENLEGE 2199
             L++ +++  + +L+   + + +L A   +LEA L+  +    E
Sbjct: 1841 ELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884



 Score =  146 bits (369), Expect = 2e-34
 Identities = 232/1047 (22%), Positives = 445/1047 (42%), Gaps = 135/1047 (12%)

Query: 1333 QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV-----------EELH 1381
            + L + + E R +R +   +E + +EL      + QEK  L  ++           E  H
Sbjct: 896  EELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCH 955

Query: 1382 RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
              ++ + Q    ++G V+ L   LE E+ +  + D+      +E    + + ++ +    
Sbjct: 956  LLIKSKVQ----LEGKVKELSERLEDEEEV--NADLAARRRKLEDECTELKKDIDDLKLT 1009

Query: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL---------- 1491
            LA+AE E   T+ K KN  E+      S+ +   + + L+   Q+   +L          
Sbjct: 1010 LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSAL 1069

Query: 1492 ----VKADQQLRSLQADAK-------DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKK 1540
                ++ +QQ+  L+   +       D E+ K K E  LK   + VA    D Q L +K 
Sbjct: 1070 TKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKL 1129

Query: 1541 EKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD 1600
            +K   EL +L   +E  +       + +KE +   +    ELE  ++     +++ A   
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189

Query: 1601 RQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV----KSLLEELSFQK 1656
            R+L    E L    G    A A  +E  R  E E+      + E     ++ +  L  ++
Sbjct: 1190 RELEELSERLEEAGG----ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQ 1245

Query: 1657 GELNVQISERKTQLTLIKQEIEKEEENLQVV-------LRQMSKHKTELKNILDMLQLEN 1709
             E   ++ E+   L  ++Q++EKE+  L++        +  +++ K   + +    + + 
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305

Query: 1710 HELQGLKLQHDQRVSELEKTQVAVLE-EKLELENLQQ-----ISQQQKGEIEWQKQLLER 1763
             E + +K++  QR      TQ   L+ E  EL  L +     ISQ  +G+     Q LE 
Sbjct: 1306 SEAK-IKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGK-ALAAQSLEE 1363

Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
             +R++E  +    AL   V+ L  + + L+E+ +   +  A+ +R+L+ A  N+++ Q  
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKA--NAEVAQWR 1421

Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
              K E +  +  +EL++  + KL+L        Q+ +E  EA N+    L   +  L   
Sbjct: 1422 -SKYEADAIQRTEELEEAKK-KLALR------LQEAEEGVEAANAKCSSLEKAKLRLQTE 1473

Query: 1884 KQD----LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1939
             +D    L   T     L  +Q  L++ + E   + E+ Q+E E  Q++ + L  E+   
Sbjct: 1474 SEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533

Query: 1940 KLKLVQQEMMFQRLQKERESEESKLE--TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVL 1997
            +    +     + L++E ++ + ++   T +V+L  +  Q   EL   K  L+   S++ 
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQ---ELEKTKKALEGEKSEIQ 1590

Query: 1998 AA-EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLAL----QKEADSMR 2052
            AA EE    L+ EE     ++  LSQ K   +E +++L EK  E   L    Q+  +S++
Sbjct: 1591 AALEEAEGALELEETKTLRIQLELSQVK---AEVDRKLAEKDEECANLRRNHQRAVESLQ 1647

Query: 2053 ADF---SLLRNQFLTERKKAE--------------KQVASLKEALKIQRSQLEKNLLEQK 2095
            A     +  RN+ L  +KK E              +Q    + A ++ ++QL++    + 
Sbjct: 1648 ASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRD 1707

Query: 2096 QENSCIQKEMATIELVAQDNHERARRLMKELNQMQ--YEYTELKKQMANQKDLE-RRQME 2152
            +E    Q+  A +   AQ    RA  L  EL +++   E  E  +++A Q+ LE   ++ 
Sbjct: 1708 EE----QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLN 1763

Query: 2153 ISDAMRTLKSEVKDEIRTSLKNLNQFLPEL-----------------PADLEAILERNEN 2195
            +  +  T     K ++   L  L+  + E                   A +   L++ ++
Sbjct: 1764 LLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD 1823

Query: 2196 LEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHC 2255
                LE +K+ L  T+ E   + +L  ++   +     G+   +KL  +   L+A+L   
Sbjct: 1824 TSAHLERMKKTLEQTVRE--LQARLEEAEQAALR---GGKKQVQKLEAKVRELEAELDAE 1878

Query: 2256 MSKQAEVLIKGKRQTEGTLHSLRRQVD 2282
              K AE L KG R+ E  +  L  Q +
Sbjct: 1879 QKKHAEAL-KGVRKHERRVKELAYQAE 1904



 Score =  135 bits (341), Expect = 4e-31
 Identities = 204/972 (20%), Positives = 425/972 (43%), Gaps = 115/972 (11%)

Query: 1425 EKTLLKRRSELREADRLLAEAESE--------LSCTKEKTKNAVE------KFTDAK--- 1467
            E+ L   R+ELR     LA AE++        +S T+EK   A++         DA+   
Sbjct: 895  EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954

Query: 1468 ----RSLLQTESDAEELERRAQET-------AVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
                +S +Q E   +EL  R ++        A    K + +   L+ D  DL+    K E
Sbjct: 955  HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAE 1014

Query: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA---ERNEDHHLQVLKESEV 1573
            +  +     V     +   L +   +LT+E + LQ+  + A    + E+  +  L ++++
Sbjct: 1015 KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL 1074

Query: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE--LHLLQGSMVQAKADLQEALRLG 1631
             L+ +  +LE      + +Q++   +D +   +K E  L L Q S+  A  D Q+     
Sbjct: 1075 RLEQQVEDLE-----CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL---- 1125

Query: 1632 ETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQM 1691
            E ++ +K + + ++   +E+      ++  +I E + +   +++E+E E      V +Q 
Sbjct: 1126 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR 1185

Query: 1692 SKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQIS 1747
            ++   EL+ + + L+       G +    +R +EL     + + A L  +  +  L++  
Sbjct: 1186 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQ 1245

Query: 1748 QQQKGEIEWQKQLLERDKREIERMTAESRA----LQSCVECLSKEKEDLQEKCDIWEKKL 1803
             +   E+  Q   L+R ++++E+  +E R     L + VE L++ K   ++ C  +E +L
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305

Query: 1804 AQTK-------RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
            ++ K       R LA A       Q+   +L   + + +  + QL+R K      +  ++
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
            +QL+E+ +A ++L   +  ++   +L ++      + Q  L    ++   ++++W +++E
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425

Query: 1917 --DCQKEEETKQQ------QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE--- 1965
                Q+ EE ++       +LQ  +  +E    K    E    RLQ E E    +LE   
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485

Query: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE--------ERWCESLE 2017
            ++   L ++Q  LE+ L +++ + +++  ++ AA+   R L  E        E   E+LE
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545

Query: 2018 KTLSQTKRQLSEREQQLVEK---SGE-LLALQKEADSMRADFSLLRNQFLTERKKAEKQV 2073
             TL +  + L E    L ++   SG+ +  L+K   ++  + S +      +    E + 
Sbjct: 1546 -TLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEI------QAALEEAEG 1598

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA-RRLMKELN---QM 2129
            A   E  K  R QLE + ++ + +    +K+     L  + NH+RA   L   L+   + 
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANL--RRNHQRAVESLQASLDAETRA 1656

Query: 2130 QYEYTELKKQM-ANQKDLE-------RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPE 2181
            + E   LKK+M  +  DLE       R+  E   A R +++++K+E +       +   E
Sbjct: 1657 RNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE-QAGRDEEQRLAAE 1715

Query: 2182 LPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK- 2240
            L    +A+  R   L  ELE L+      + +G  E     ++  +++   R   L  + 
Sbjct: 1716 LHEQAQALERRASLLAAELEELRA----ALEQG--ERSRRLAEQELLEATERLNLLHSQN 1769

Query: 2241 --LRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASS 2298
              L +++ +L+A L   +S + E   + +R+ E      ++ +     +      +  +S
Sbjct: 1770 TGLLNQKKKLEADLAQ-LSGEVEEAAQERREAE---EKAKKAITDAAMMAEELKKEQDTS 1825

Query: 2299 PSLSQLESSLTE 2310
              L +++ +L +
Sbjct: 1826 AHLERMKKTLEQ 1837



 Score =  123 bits (308), Expect = 2e-27
 Identities = 165/792 (20%), Positives = 339/792 (42%), Gaps = 103/792 (13%)

Query: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
            E E+ RL   ++  ++  R E  + A +R+  +   EL   +D L + ++ LE E  EL 
Sbjct: 1217 EAELGRLRRELE--EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274

Query: 1382 RTVQKRQQQKDFIDGNVESLM-TELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
              V       D +  NVE+L   +   EK  + +ED + E +   + L ++ ++      
Sbjct: 1275 MEV-------DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRG 1327

Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
             L     ELS   E+ +  + + +  K    Q+    EEL R+ +E +         +++
Sbjct: 1328 RLQTESGELSRLLEEKECLISQLSRGKALAAQS---LEELRRQLEEESKAKSALAHAVQA 1384

Query: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE----KLTEELQKLQKDIEM 1556
            L+ D   L +   ++ E   E+ ++++  +++      K E    + TEEL++ +K + +
Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLAL 1444

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEM-----------AVLDRQLGH 1605
                    LQ  +E      AK + LEK K ++ ++ +++           A LD++  H
Sbjct: 1445 -------RLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRH 1497

Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGE---TEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
             +  L   +    + + +L+ A R      TE+    +   E    LE L  +   L  +
Sbjct: 1498 LERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEE 1557

Query: 1663 ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQR 1722
            IS+   Q++L  + I++ E+  + +  + S+ +  L+     L+LE  +   ++L+  Q 
Sbjct: 1558 ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQV 1617

Query: 1723 VSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV 1782
             +E+++    + E+  E  NL++  Q+    ++               + AE+RA    +
Sbjct: 1618 KAEVDRK---LAEKDEECANLRRNHQRAVESLQ-------------ASLDAETRARNEAL 1661

Query: 1783 ECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN 1842
                K + DL +     E +L    R    A+  +++ Q+ L++ +    + Q+   +L+
Sbjct: 1662 RLKKKMEGDLNDL----ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH 1717

Query: 1843 RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT 1902
                +L    S +  +L+E R A+   +           LA+Q+LL  T+  ++L S+ T
Sbjct: 1718 EQAQALERRASLLAAELEELRAALEQGERSR-------RLAEQELLEATERLNLLHSQNT 1770

Query: 1903 -------RLQKDISEWANRFEDCQKEEETKQQQLQ-------VLQNEIEENKLKLVQQEM 1948
                   +L+ D+++ +   E+  +E    +++ +       ++  E+++ +      E 
Sbjct: 1771 GLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1830

Query: 1949 MFQRLQKERESEESKLETSKVT-----------LKEQQHQLEKELTDQKSKLDQVLSKVL 1997
            M + L++     +++LE ++             L+ +  +LE EL  ++ K  + L  V 
Sbjct: 1831 MKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR 1890

Query: 1998 AAEERVRTLQ---EEER--------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK 2046
              E RV+ L    EE+R          + L+  +   KRQ  E EQQ      +    Q 
Sbjct: 1891 KHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQH 1950

Query: 2047 EADSM--RADFS 2056
            E D    RAD +
Sbjct: 1951 ELDDAEERADMA 1962



 Score =  122 bits (306), Expect = 4e-27
 Identities = 195/893 (21%), Positives = 366/893 (40%), Gaps = 163/893 (18%)

Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE-------CEVEE 1379
            ++ED+   L+ +K+       +KR+ E +++    ++ D  Q+K+ LE        E+ +
Sbjct: 1079 QVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQ 1138

Query: 1380 LHRTVQKRQ-----QQKDF--IDGNVESLMTELEIEKSL-----KHHEDIVDEIECIEKT 1427
            L   V+  Q      QK    +    E L  ELE E++      K   +   E+E + + 
Sbjct: 1139 LSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSER 1198

Query: 1428 L--------------LKRRSELREADRLLAEA----ESELSCTKEKTKNAV----EKFTD 1465
            L               KR +EL    R L EA    E+ ++  + K         E+   
Sbjct: 1199 LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDS 1258

Query: 1466 AKRSLLQTESDAEELERRAQETAVN---LVKADQQLRSLQADAKD-LEQHKIKQEEILK- 1520
             +R   + E +  EL     + A N   L +A      L    +D L + KIK EE+ + 
Sbjct: 1259 LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 1318

Query: 1521 ----------------EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED-- 1562
                            E+++++  K+     LS+ K    + L++L++ +E   + +   
Sbjct: 1319 LADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSAL 1378

Query: 1563 -HHLQVLKESEVLLQAK-------RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQ 1614
             H +Q L+    LL+ +       +AEL++L S+  ++  +           K E   +Q
Sbjct: 1379 AHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW--------RSKYEADAIQ 1430

Query: 1615 GSMVQAKADLQEALRLGETE-----VTEKCNHIREVKSLLE------------------E 1651
             +    +A  + ALRL E E        KC+ + + K  L+                   
Sbjct: 1431 RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAA 1490

Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIE---KEEENLQVVLRQMSKHKTELKNILDMLQLE 1708
            L  ++  L   + ER+ Q   +++E+E   +E   L   L ++     E    L+ L+ E
Sbjct: 1491 LDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRE 1550

Query: 1709 NHELQGLKLQHDQRVS-------ELEKTQVAVLEEKLELENLQQISQQQKG--EIEWQKQ 1759
            N  LQ        +VS       ELEKT+ A+  EK E   +Q   ++ +G  E+E  K 
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSE---IQAALEEAEGALELEETKT 1607

Query: 1760 L-----LERDKREIERMTAE------------SRALQSCVECLSKEKEDLQEKCDIWEK- 1801
            L     L + K E++R  AE             RA++S    L  E     E   + +K 
Sbjct: 1608 LRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKM 1667

Query: 1802 --KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
               L   +  L  A   +   Q+    ++  +++ Q   D+  R    LH    A++++ 
Sbjct: 1668 EGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRA 1727

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEWA 1912
                  +  L+  L   +    LA+Q+LL  T+  ++L S+ T       +L+ D+++ +
Sbjct: 1728 SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLS 1787

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
               E+  +E    +          E+ K  +    MM + L+KE+++  + LE  K TL+
Sbjct: 1788 GEVEEAAQERREAE----------EKAKKAITDAAMMAEELKKEQDT-SAHLERMKKTLE 1836

Query: 1973 EQQHQLEKELTD-QKSKLDQVLSKVLAAEERVRTLQ-----EEERWCESLEKTLSQTKRQ 2026
            +   +L+  L + +++ L     +V   E +VR L+     E+++  E+L K + + +R+
Sbjct: 1837 QTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL-KGVRKHERR 1895

Query: 2027 LSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
            + E   Q  E    L  +Q   D +++     + QF    ++A   +A  ++A
Sbjct: 1896 VKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKA 1948



 Score =  120 bits (301), Expect = 2e-26
 Identities = 172/862 (19%), Positives = 368/862 (42%), Gaps = 88/862 (10%)

Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
            EEL  +     + L++A  + R ++ + + L   +     I   I    A K+  +  L 
Sbjct: 823  EELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLF 882

Query: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMA 1597
             K + L   L+  Q + E+A    +  L+ L+ +    +AKR ELE+    +T ++ ++A
Sbjct: 883  FKMKPL---LRSAQAEEELAALRAE--LRGLRGALAAAEAKRQELEETHVSITQEKNDLA 937

Query: 1598 VL----DRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELS 1653
            +        L   +E  HLL  S VQ +  ++E        ++E+     EV +   +L+
Sbjct: 938  LQLQAEQDNLADAEERCHLLIKSKVQLEGKVKE--------LSERLEDEEEVNA---DLA 986

Query: 1654 FQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQ 1713
             ++ +L  + +E K  +  +K  + K E+  Q    ++     E+  + + +     E +
Sbjct: 987  ARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKK 1046

Query: 1714 GLKLQHDQRVSELEKTQ---VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER 1770
             L+  H Q + +L+  +    A+ + KL LE  QQ+ +  +  +E +K+L    +R   +
Sbjct: 1047 ALQEAHQQALGDLQAEEDRVSALTKAKLRLE--QQV-EDLECSLEQEKKLRMDTERAKRK 1103

Query: 1771 MTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELN 1830
            +  + +  Q  V   +++K+ L+EK    + +L+Q    +   +      Q  +++L+  
Sbjct: 1104 LEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQAR 1163

Query: 1831 VRKLQQELD-------QLNRDKLSLHNDISAMQQQLQE-------KREAVNSLQEELANV 1876
              +L++EL+       ++ + +     ++  + ++L+E       +RE     + EL  +
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRL 1223

Query: 1877 QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
            +  L  A        +H+  + + + +  +  +E   + +  Q+  +  +++   L+ E+
Sbjct: 1224 RRELEEA------ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEV 1277

Query: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV 1996
            ++    +          +K   + E +L  +K+ ++E Q QL  + + Q+ +L       
Sbjct: 1278 DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQL-ADASTQRGRLQ------ 1330

Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS 2056
              + E  R L+E+E     L +  +   + L E  +QL E+S    AL     ++R D  
Sbjct: 1331 TESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCD 1390

Query: 2057 LLRNQFLTERK-KAEKQVASLKEALKIQ--RSQLEKNLLEQKQENSCIQKEMATIELVAQ 2113
            LLR Q   E + +AE Q    K   ++   RS+ E + +++ +E    +K++A     A+
Sbjct: 1391 LLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE 1450

Query: 2114 DNHERAR-----------RLMKELNQMQYEYTEL--------KKQMANQKDLERRQMEIS 2154
            +  E A            RL  E   +  E            KKQ   ++ LE R+ +  
Sbjct: 1451 EGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEE 1510

Query: 2155 DAMRTLKSEVKDE--IRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMN 2212
            +  R L++  ++   + T L  L     E    LE +   N+NL+ E+  L + +  +  
Sbjct: 1511 EMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGK 1570

Query: 2213 EGPFEEKL------NFSQVHIMDEHWRG-----EALREKLRHREDRLKAQLRHCMSKQAE 2261
                 EK         S++    E   G     E    +++    ++KA++   ++++ E
Sbjct: 1571 SIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE 1630

Query: 2262 VLIKGKRQTEGTLHSLRRQVDA 2283
                 +R  +  + SL+  +DA
Sbjct: 1631 ECANLRRNHQRAVESLQASLDA 1652



 Score =  113 bits (282), Expect = 2e-24
 Identities = 212/941 (22%), Positives = 388/941 (41%), Gaps = 190/941 (20%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
            ++++ L+  L K   E +  ++K     EE+   D+    L +E    +++ ++   DL 
Sbjct: 1001 KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQ 1060

Query: 330  TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
             + +    +   LT+A   +  LEQ++   +   + E      +E A             
Sbjct: 1061 AEED----RVSALTKA---KLRLEQQVEDLECSLEQEKKLRMDTERA------------- 1100

Query: 390  KSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE------ 443
            K + + ++  T+  + D+AQ     K + +E+L+     L   + L  ++ED++      
Sbjct: 1101 KRKLEGDLKLTQESVADAAQ----DKQQLEEKLKKKDSEL---SQLSLRVEDEQLLGAQM 1153

Query: 444  -KKISAAQTRLSELHDEIE-------KAEQQILRATEEFKQLEEAIQLKKISEAGKDLLY 495
             KKI   Q R  EL +E+E       + E+Q   A  E ++L E ++    + AG+    
Sbjct: 1154 QKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGC 1213

Query: 496  KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKE-IKDLQIAIDSLDSKDPKHSHMK 554
            ++    L    +LR+E  +  L+ E     +  KQ E   +L   +DSL     +    K
Sbjct: 1214 RKREAEL---GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL-----QRVRQK 1265

Query: 555  AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDL 614
             +K   E ++++       L + ++ +    A   +  +  E+QL+E +I   E L++ L
Sbjct: 1266 LEKEKSELRMEV-----DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE-LQRQL 1319

Query: 615  EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMR 674
                        T +G+      E  +L +EKE L+ +L+  +       + A   E +R
Sbjct: 1320 ADA--------STQRGRLQTESGELSRLLEEKECLISQLSRGKA------LAAQSLEELR 1365

Query: 675  KELAELESA-----------------LQEQHEVNASLQ-QTQGDLSAYEAELEARLNLRD 716
            ++L E   A                 L+EQHE  A  Q + Q  LS   AE+    +  +
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425

Query: 717  AEANQLKEELEKV-------------------TRLTQLEQSALQAELEKERQALK----- 752
            A+A Q  EELE+                     + + LE++ L+ + E E   L+     
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485

Query: 753  ---NALGKAQFS-----EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLV 804
                AL K Q       EE+ ++  E+  +L+  Q ++  L  +L  F+    H      
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL--FRLRHGH------ 1537

Query: 805  RPEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQK-------QFSEILARSKW 856
              EE    ++ L+R+ K    E++ +     + GKS+ +L+K       + SEI A  + 
Sbjct: 1538 --EEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595

Query: 857  ERDEAQVRERK-LQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENE 915
                 ++ E K L+ ++ L Q K A    +  +  E     R N  +R  E+    ++ E
Sbjct: 1596 AEGALELEETKTLRIQLELSQVK-AEVDRKLAEKDEECANLRRNH-QRAVESLQASLDAE 1653

Query: 916  IHYLQENLKSMEEIQG-LTDLQLQ---------EADEEKERILAQLRELEKKKKLED--- 962
                 E L+  ++++G L DL+LQ         EA      + AQL+E +  +  E    
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLA 1713

Query: 963  AKSQEQVFGLDK-------ELKKLKKAVATSDK---LATAELTIAKDQLKSLH------- 1005
            A+  EQ   L++       EL++L+ A+   ++   LA  EL  A ++L  LH       
Sbjct: 1714 AELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1773

Query: 1006 --------------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELLQN 1048
                          G V +  QER E  ++A++    AA  A +L + +   A +E ++ 
Sbjct: 1774 NQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1833

Query: 1049 LLRQ--KGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQ 1087
             L Q  +  Q RLE  +     G   QV ++E     +E +
Sbjct: 1834 TLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874



 Score =  113 bits (282), Expect = 2e-24
 Identities = 145/690 (21%), Positives = 303/690 (43%), Gaps = 92/690 (13%)

Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK 1386
            ++E++ + L     +   ++    +  + +EE    I  L + K      +EEL R +++
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 1370

Query: 1387 RQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR------EADR 1440
              + K  +   V++L  + ++ +  +H E+   + E +++ L K  +E+       EAD 
Sbjct: 1371 ESKAKSALAHAVQALRHDCDLLRE-QHEEEAEAQAE-LQRLLSKANAEVAQWRSKYEADA 1428

Query: 1441 L-----LAEAESELSCTKEKTKNAVEKFTDAKRSL------LQTESDAEELE-RRAQETA 1488
            +     L EA+ +L+   ++ +  VE       SL      LQTES+   LE  RA   A
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAA 1488

Query: 1489 VNLVKADQQL---------------RSLQADAKDLE-------------QHKIKQEEILK 1520
              L K  + L               R L+A  ++               +  ++  E LK
Sbjct: 1489 AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 1548

Query: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
              NK +  + SD         K  +EL+K +K +E  E++E      L+E+E  L+ +  
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALE-GEKSEIQ--AALEEAEGALELEET 1605

Query: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640
            +  +++ +++   Q  A +DR+L  K EE   L+ +  +A   LQ +L        E   
Sbjct: 1606 KTLRIQLELS---QVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR 1662

Query: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE---ENLQVVLRQMSKHKTE 1697
              ++++  L +L  Q G    Q +E +    L++ ++++E+   +  Q +  ++ +    
Sbjct: 1663 LKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQA 1722

Query: 1698 LKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL---ENLQQISQQQKGEI 1754
            L+    +L  E  EL+   L+  +R   L + ++    E+L L   +N   ++Q++K E 
Sbjct: 1723 LERRASLLAAELEELRAA-LEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEA 1781

Query: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKEDLQEKCDIWEKKLAQTKRV 1809
            +  +   E ++   ER  AE +A ++  +        K+++D     +  +K L QT R 
Sbjct: 1782 DLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRE 1841

Query: 1810 LAAAEENSKME-----QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKRE 1864
            L A  E ++       +  ++KLE  VR+L+ ELD                  + ++  E
Sbjct: 1842 LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDA-----------------EQKKHAE 1884

Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
            A+  +++    V++    A++D  +  + QD++     +LQ  +  +  +FE+ +++  T
Sbjct: 1885 ALKGVRKHERRVKELAYQAEEDRKNLARMQDLV----DKLQSKVKSYKRQFEEAEQQANT 1940

Query: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQ 1954
               + +  Q+E+++ + +    E    +L+
Sbjct: 1941 NLAKYRKAQHELDDAEERADMAETQANKLR 1970



 Score =  100 bits (248), Expect = 2e-20
 Identities = 184/788 (23%), Positives = 347/788 (44%), Gaps = 120/788 (15%)

Query: 414  KKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEE 473
            +++E +E++  D    R    L+ +  + +K I   +  L++   E +  E ++   TEE
Sbjct: 973  ERLEDEEEVNADLAARR--RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEE 1030

Query: 474  FKQLEEAI-----QLKKISEAGKDLL------YKQLSGRLQLVNKLRQEALDLELQMEKQ 522
               L+E++     + K + EA +  L        ++S   +   +L Q+  DLE  +E++
Sbjct: 1031 MAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE 1090

Query: 523  KQ----EIAGKQKEIKDLQIAIDSL--DSKDPKHSHMKAQKSGKE-QQLDIMNKQYQQLE 575
            K+        K+K   DL++  +S+   ++D +    K +K   E  QL +  +  Q L 
Sbjct: 1091 KKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLG 1150

Query: 576  SRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIK--GQAT 633
            +++ + +  +    EE   LEE+L E + AA   ++K        L+E    ++  G A+
Sbjct: 1151 AQMQKKIKELQARAEE---LEEEL-EAERAARARVEKQRAEAARELEELSERLEEAGGAS 1206

Query: 634  QAQNE-CRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
              Q E CRK R+ +   L+R  E    R +  + A     +R++ AE  + L EQ +   
Sbjct: 1207 AGQREGCRK-REAELGRLRRELEEAALRHEATVAA-----LRRKQAEGAAELGEQVD--- 1257

Query: 693  SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
            SLQ+ +  L   ++EL  R+ + D  AN     +E +TR         +A  EK  +  +
Sbjct: 1258 SLQRVRQKLEKEKSEL--RMEVDDLAAN-----VETLTR--------AKASAEKLCRTYE 1302

Query: 753  NALGKAQFS-EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA 811
            + L +A+   EE +++ ++   +   LQ ++  L + L++ +     ++  L R + +AA
Sbjct: 1303 DQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE----CLISQLSRGKALAA 1358

Query: 812  R-VDELRRKLK--------LGTGEMNIHSPSDVL-------GKSLADLQKQFSEILA--- 852
            + ++ELRR+L+        L      +    D+L        ++ A+LQ+  S+  A   
Sbjct: 1359 QSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVA 1418

Query: 853  --RSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQAC------------------ 890
              RSK+E D  Q  E   + ++++AL+ ++   G E     C                  
Sbjct: 1419 QWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478

Query: 891  ---ERALEARMNFDKRQH--EARIQQMENEIHYLQENLKSME-EIQGL-TDL-QLQEADE 942
               ERA  A    DK+Q   E  +++   +   +Q  L++ + E +GL T+L +L+   E
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE 1538

Query: 943  EKERILAQLRELEK--KKKLEDAKSQEQVFGLD-KELKKLKKAVATSDKLATAELTIAKD 999
            E    L  L+   K  ++++ D   Q  + G   +EL+K KKA+        A L  A+ 
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598

Query: 1000 QLKSLHGTVMKINQERAEELQEAER-FSRKAAQAARDLTRAEAEIELLQNLL----RQKG 1054
             L+      ++I  E ++   E +R  + K  + A      +  +E LQ  L    R + 
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658

Query: 1055 EQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLE 1114
            E  RL+ +  G     +   LE++  + T  RQ TE      ++     + + G +    
Sbjct: 1659 EALRLKKKMEG-----DLNDLELQLGHAT--RQATEAQAATRLMQAQLKEEQAGRDEEQR 1711

Query: 1115 EIAELRRE 1122
              AEL  +
Sbjct: 1712 LAAELHEQ 1719



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 157/709 (22%), Positives = 300/709 (42%), Gaps = 112/709 (15%)

Query: 517  LQMEKQKQEIAGKQKEIKDLQIAIDSLDSK----DPKHSHMKAQKSGKEQQLDIMNKQYQ 572
            L+  + ++E+A  + E++ L+ A+ + ++K    +  H  +  +K+    QL        
Sbjct: 889  LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948

Query: 573  QLESRLDEILSRIAKETEEIKDLEEQLT-EGQIAAN-EALKKDLEGVISGLQEYLGTIKG 630
              E R   ++    +   ++K+L E+L  E ++ A+  A ++ LE   + L++ +  +K 
Sbjct: 949  DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008

Query: 631  QATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690
               +A+ E    +   E  ++ LTE        E+ A+D    R  L + + ALQE H  
Sbjct: 1009 TLAKAEKE----KQATENKVKNLTE--------EMAALDESVAR--LTKEKKALQEAH-- 1052

Query: 691  NASLQQTQGDLSAYE----AELEARLNL-RDAEANQLKEELEKVTRL-TQLEQSALQAEL 744
                QQ  GDL A E    A  +A+L L +  E  +   E EK  R+ T+  +  L+ +L
Sbjct: 1053 ----QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL 1108

Query: 745  EKERQALKNAL-GKAQFSEEKEQENSELHAKLKHLQDDNNL---LKQQLKDFQNHLNHVV 800
            +  ++++ +A   K Q  E+ ++++SEL      ++D+  L   +++++K+ Q     + 
Sbjct: 1109 KLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168

Query: 801  DGLVRPEEVAARVDELRRKLKLGTGEMN--IHSPSDVLGKSLADLQKQFSEILARSKWER 858
            + L       ARV++ R +      E++  +              +K+ +E L R + E 
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAE-LGRLRREL 1227

Query: 859  DEAQVRE-------RKLQEEMALQQEKLATGQEEFRQACER-ALEARMNFDK-------- 902
            +EA +R        R+ Q E A +  +     +  RQ  E+   E RM  D         
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETL 1287

Query: 903  -----------RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEAD---EEKERIL 948
                       R +E ++ + + ++  LQ  L      +G    +  E     EEKE ++
Sbjct: 1288 TRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLI 1347

Query: 949  AQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK------ 1002
            +QL     + K   A+S E++    +E  K K A+A + +    +  + ++Q +      
Sbjct: 1348 SQL----SRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 1403

Query: 1003 -SLHGTVMKINQE--------------RAEELQEA-ERFSRKAAQAARDLTRAEAEIELL 1046
              L   + K N E              R EEL+EA ++ + +  +A   +  A A+   L
Sbjct: 1404 AELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSL 1463

Query: 1047 QNL---LRQKGEQFRLEMEK-TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTG 1102
            +     L+ + E   LE+E+ T      + +   +E+  E   RQ  E   +Q  L+   
Sbjct: 1464 EKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE---MQRELEAAQ 1520

Query: 1103 SDNKG----------GFENVLEEIAELRREVSYQNDYISSMADPFKRRG 1141
             +++G          G E  LE +  L+RE     + IS + D     G
Sbjct: 1521 RESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSG 1569



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 148/748 (19%), Positives = 315/748 (42%), Gaps = 118/748 (15%)

Query: 271  EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNT 330
            +VE L+R L     +   L+++       ++ ++ L   L     L  QS EEL+  L  
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 1370

Query: 331  KNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK 390
            +++  K       +A +   +L +E    + +A+ E         AE+ +         +
Sbjct: 1371 ESKA-KSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQ--------WR 1421

Query: 391  SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
            S+Y+ +       + ++ + + ++  E +E +   +           +L+ + + ++   
Sbjct: 1422 SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481

Query: 451  TRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDL---LYKQLSGR---L 502
             R +     ++K ++ + RA EE ++ EE +Q  L+      + L   L++   G    L
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541

Query: 503  QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
            + +  L++E  +L+ ++     +++   K I++L+    +L+ +    S ++A     E 
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK---SEIQAALEEAEG 1598

Query: 563  QLDIMNKQYQQLESRLDEILS----RIAKETEE-----------IKDLEEQLTEGQIAAN 607
             L++   +  +++  L ++ +    ++A++ EE           ++ L+  L     A N
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658

Query: 608  EAL--KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI 665
            EAL  KK +EG ++ L+  LG    QAT+AQ   R ++ +       L E +  RD+ + 
Sbjct: 1659 EALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ-------LKEEQAGRDEEQR 1711

Query: 666  VAMDAENMRKELAELESALQ-EQHEVNASLQQTQGDLSAYEAEL---EARLNLRDAEANQ 721
            +A +     + L    S L  E  E+ A+L+Q +      E EL     RLNL  ++   
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG 1771

Query: 722  LKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDD 781
            L  + +K+    + + + L  E+E                 E  QE  E   K K    D
Sbjct: 1772 LLNQKKKL----EADLAQLSGEVE-----------------EAAQERREAEEKAKKAITD 1810

Query: 782  NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLA 841
              ++ ++LK              + ++ +A ++ +++ L+    E+             A
Sbjct: 1811 AAMMAEELK--------------KEQDTSAHLERMKKTLEQTVRELQ------------A 1844

Query: 842  DLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFD 901
             L++     L   K +  + + + R+L+ E+  +Q+K A            AL+      
Sbjct: 1845 RLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHA-----------EALKG----- 1888

Query: 902  KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLE 961
             R+HE R++++    +  +E+ K++  +Q L D +LQ   +  +R   Q  E E++    
Sbjct: 1889 VRKHERRVKEL---AYQAEEDRKNLARMQDLVD-KLQSKVKSYKR---QFEEAEQQANTN 1941

Query: 962  DAKSQEQVFGLDKELKKLKKAVATSDKL 989
             AK ++    LD   ++   A   ++KL
Sbjct: 1942 LAKYRKAQHELDDAEERADMAETQANKL 1969



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 127/549 (23%), Positives = 236/549 (42%), Gaps = 46/549 (8%)

Query: 270  EEVERLERDLEKKMIETEELKSK-------QTRFLEEIKNQDKLNKSLKEE----AMLQK 318
            E    L+R L K   E  + +SK       +T  LEE K +  L     EE    A  + 
Sbjct: 1401 EAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKC 1460

Query: 319  QSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEI 378
             S E+ K  L T++E     T+EL RA      L+++    +  A  E          E+
Sbjct: 1461 SSLEKAKLRLQTESE---DVTLELERATSAAAALDKKQRHLE-RALEERRRQEEEMQREL 1516

Query: 379  DKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQ 438
            + A  ES  +G   ++      E+         + K ++ +     D ++L G +  + +
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELE 1576

Query: 439  LEDK--EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK 496
               K  E + S  Q  L E    +E  E + LR   E  Q++  +  +K++E  KD    
Sbjct: 1577 KTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVD-RKLAE--KDEECA 1633

Query: 497  QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQK-EIKDLQI--------AIDSLDSKD 547
             L    Q   +  Q +LD E +   +   +  K + ++ DL++        A ++  +  
Sbjct: 1634 NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATR 1693

Query: 548  PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
               + +K +++G++++  +  + ++Q ++ L+   S +A E EE++   EQ    +  A 
Sbjct: 1694 LMQAQLKEEQAGRDEEQRLAAELHEQAQA-LERRASLLAAELEELRAALEQGERSRRLAE 1752

Query: 608  EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
            + L   LE       E L  +  Q T   N+ +KL  +   L   + E  QER + E  A
Sbjct: 1753 QEL---LEAT-----ERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA 1804

Query: 668  MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQL---KE 724
              A      +AE    L+++ + +A L++ +  L     EL+ARL   +AE   L   K+
Sbjct: 1805 KKAITDAAMMAE---ELKKEQDTSAHLERMKKTLEQTVRELQARLE--EAEQAALRGGKK 1859

Query: 725  ELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL 784
            +++K+    +  ++ L AE +K  +ALK      +  +E   +  E    L  +QD  + 
Sbjct: 1860 QVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDK 1919

Query: 785  LKQQLKDFQ 793
            L+ ++K ++
Sbjct: 1920 LQSKVKSYK 1928



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 111/503 (22%), Positives = 220/503 (43%), Gaps = 36/503 (7%)

Query: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL 1888
            L   + ++EL  L  +   L   ++A + + QE  E   S+ +E  ++   L   + +L 
Sbjct: 889  LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948

Query: 1889 HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM 1948
               +   +L+  + +L+  + E + R ED ++       + + L++E  E K  +   ++
Sbjct: 949  DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008

Query: 1949 MFQRLQKERESEESK---LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005
               + +KE+++ E+K   L      L E   +L KE    +    Q L  + A E+RV  
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068

Query: 2006 LQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
            L +     E+  E LE +L Q K+   + E+   +  G+L   Q+      AD +  + Q
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESV----ADAAQDKQQ 1124

Query: 2062 FLTERKKAEKQVASLK---EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHER 2118
               + KK + +++ L    E  ++  +Q++K + E +     +++E+   E  A+   E+
Sbjct: 1125 LEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA-ERAARARVEK 1183

Query: 2119 AR-RLMKELNQMQYEYTELKKQMANQKD-LERRQMEISDAMRTLKSEVKDEIRTSLKNLN 2176
             R    +EL ++     E     A Q++   +R+ E+    R L+ E       ++  L 
Sbjct: 1184 QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELE-EAALRHEATVAALR 1242

Query: 2177 QFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEA 2236
            +   E  A+L   ++  + +  +LE  K  L   +++              ++   R +A
Sbjct: 1243 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD----------LAANVETLTRAKA 1292

Query: 2237 LREKL-RHREDRL---KAQLRHCMSKQAEVLI-KGKRQTE-GTLHSLRRQVDALGELVTS 2290
              EKL R  ED+L   K ++     + A+    +G+ QTE G L  L  + + L   ++ 
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352

Query: 2291 TSADSASSPSLSQLESSLTEDSQ 2313
              A +A   SL +L   L E+S+
Sbjct: 1353 GKALAAQ--SLEELRRQLEEESK 1373



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 108/515 (20%), Positives = 203/515 (39%), Gaps = 76/515 (14%)

Query: 1319 HNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE 1378
            H  E  +  LE + +  K+ + E   +      S K ++EL      L  EK  ++  +E
Sbjct: 1535 HGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALE 1594

Query: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREA 1438
            E    ++  + +   I   +E    + E+++ L   ++     EC       RR+  R  
Sbjct: 1595 EAEGALELEETKTLRI--QLELSQVKAEVDRKLAEKDE-----ECAN----LRRNHQRAV 1643

Query: 1439 DRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQL 1498
            + L A  ++E     E           A R   + E D  +LE +         +A    
Sbjct: 1644 ESLQASLDAETRARNE-----------ALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692

Query: 1499 RSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE 1558
            R +QA  K+ +  + +++ +  E+++         Q L ++   L  EL++L+  +E  E
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHE-------QAQALERRASLLAAELEELRAALEQGE 1745

Query: 1559 RNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMV 1618
            R+     + L E E+L   +R  L  L SQ T    +   L+  L         L G + 
Sbjct: 1746 RS-----RRLAEQELLEATERLNL--LHSQNTGLLNQKKKLEADLAQ-------LSGEVE 1791

Query: 1619 QAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIE 1678
            +A  + +EA    +  +T+      E+K        ++ + +  +   K  L    +E++
Sbjct: 1792 EAAQERREAEEKAKKAITDAAMMAEELK--------KEQDTSAHLERMKKTLEQTVRELQ 1843

Query: 1679 -KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK 1737
             + EE  Q  LR   K   +L                     + +V ELE    A  E+K
Sbjct: 1844 ARLEEAEQAALRGGKKQVQKL---------------------EAKVRELEAELDA--EQK 1880

Query: 1738 LELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD 1797
               E L+ + + ++   E   Q  E D++ + RM      LQS V+   ++ E+ +++ +
Sbjct: 1881 KHAEALKGVRKHERRVKELAYQ-AEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQAN 1939

Query: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
                K  + +  L  AEE + M ++   KL    R
Sbjct: 1940 TNLAKYRKAQHELDDAEERADMAETQANKLRARTR 1974



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 81/380 (21%), Positives = 158/380 (41%), Gaps = 64/380 (16%)

Query: 243  HLRSLESLEGQ-PVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIK 301
            H R++ESL+      T+ R EA          RL++ +E  + + E      TR   E +
Sbjct: 1639 HQRAVESLQASLDAETRARNEAL---------RLKKKMEGDLNDLELQLGHATRQATEAQ 1689

Query: 302  NQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKT------IELTRACQKQYELEQE 355
               +L ++  +E    +   + L ++L+ + + L+++       +E  RA  +Q E  + 
Sbjct: 1690 AATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1749

Query: 356  LAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKK 415
            LA  ++    E LN   S+              G    K+ + A  + +    +    ++
Sbjct: 1750 LAEQELLEATERLNLLHSQNT------------GLLNQKKKLEADLAQLSGEVEEAAQER 1797

Query: 416  MEPDEQLRNDHMN-------LRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
             E +E+ +    +       L+        LE  +K +   +  + EL   +E+AEQ  L
Sbjct: 1798 REAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTL---EQTVRELQARLEEAEQAAL 1854

Query: 469  RATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAG 528
            R  +  KQ+++     +  EA  D   K+ +  L+ V K  +   +L  Q E+ ++ +A 
Sbjct: 1855 RGGK--KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLAR 1912

Query: 529  KQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
             Q    DL   +D L SK      +K+ K           +Q+++ E + +  L++  K 
Sbjct: 1913 MQ----DL---VDKLQSK------VKSYK-----------RQFEEAEQQANTNLAKYRKA 1948

Query: 589  TEEIKDLEEQLTEGQIAANE 608
              E+ D EE+    +  AN+
Sbjct: 1949 QHELDDAEERADMAETQANK 1968



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 94/424 (22%), Positives = 186/424 (43%), Gaps = 55/424 (12%)

Query: 245  RSLESLEGQPVTTQDR-QEAFERFSLEEVERLERDLE---------KKMIETEE----LK 290
            ++ ++LEG+    Q   +EA     LEE + L   LE         +K+ E +E    L+
Sbjct: 1577 KTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR 1636

Query: 291  SKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ-KQ 349
                R +E ++         + EA+  K+  E   +DL  +     ++  E   A +  Q
Sbjct: 1637 RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQ 1696

Query: 350  YELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409
             +L++E A    + +        +E  E  +A +    +  +  +    A E       Q
Sbjct: 1697 AQLKEEQAGRDEEQRLA------AELHEQAQALERRASLLAAELEELRAALE-------Q 1743

Query: 410  AVQIKKMEPDEQLR-NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
              + +++   E L   + +NL  H+  +T L +++KK+ A    L++L  E+E+A Q+  
Sbjct: 1744 GERSRRLAEQELLEATERLNLL-HSQ-NTGLLNQKKKLEAD---LAQLSGEVEEAAQERR 1798

Query: 469  RATEEFKQ-LEEAIQLKKISEAGKDLLYKQLSGRLQLVNK-LRQEALDLELQMEKQKQE- 525
             A E+ K+ + +A  + +  +  +D      S  L+ + K L Q   +L+ ++E+ +Q  
Sbjct: 1799 EAEEKAKKAITDAAMMAEELKKEQDT-----SAHLERMKKTLEQTVRELQARLEEAEQAA 1853

Query: 526  IAGKQKEIKDLQIAIDSL----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESR--LD 579
            + G +K+++ L+  +  L    D++  KH+  +A K  ++ +  +    YQ  E R  L 
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHA--EALKGVRKHERRVKELAYQAEEDRKNLA 1911

Query: 580  EILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC 639
             +   + K   ++K  + Q  E +  AN  L K  +      Q  L   + +A  A+ + 
Sbjct: 1912 RMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKA-----QHELDDAEERADMAETQA 1966

Query: 640  RKLR 643
             KLR
Sbjct: 1967 NKLR 1970



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 35/167 (20%), Positives = 77/167 (46%), Gaps = 18/167 (10%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
            +LE     LE  ++ L+++  E    +A+ R  +K++++L   + +L  E  + + +  E
Sbjct: 1827 HLERMKKTLEQTVRELQARLEEAE--QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884

Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
              + V+K +++   +    E      E  K+L   +D+VD+++          S+++   
Sbjct: 1885 ALKGVRKHERRVKELAYQAE------EDRKNLARMQDLVDKLQ----------SKVKSYK 1928

Query: 1440 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
            R   EAE + +    K + A  +  DA+      E+ A +L  R ++
Sbjct: 1929 RQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  167 bits (424), Expect = 8e-41
 Identities = 225/1054 (21%), Positives = 459/1054 (43%), Gaps = 105/1054 (9%)

Query: 1333 QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE-ELHRTVQKRQQQK 1391
            + + + K E +  +    +SE + +EL   +  LL+EK  L+ +V+ E        ++ +
Sbjct: 850  KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCE 909

Query: 1392 DFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR----EADRLLAEAES 1447
              I   ++      E+ +  +  E+I  E+   ++ L    SEL+    + +  LA+ E 
Sbjct: 910  QLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 969

Query: 1448 ELSCTKEKTKNAVE----------KFTDAKRSLLQTESDAEELERRAQETAVNLV----- 1492
            E   T+ K KN  E          K +  K++L +T     + + +A+E  VN++     
Sbjct: 970  EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLD-DLQAEEDKVNILTKAKT 1028

Query: 1493 KADQQLRSLQADAK-------DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTE 1545
            K +QQ+  L+   +       DLE+ K K E  LK   +     ++D Q L +K EK   
Sbjct: 1029 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEF 1088

Query: 1546 ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1605
            E+  L   IE  +  E    + +KE +  ++    E+E  ++     +++ + L R+L  
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148

Query: 1606 KKEELHLLQGSMVQAKADLQ-------EALRLGETEVTEKCNHIREVKSLLEELSFQKGE 1658
              E L    G    A+ +L        + LR    E T    H   V +L ++ +    E
Sbjct: 1149 ISERLE-EAGGATSAQVELNKKREAEFQKLRRDLEEAT--LQHEAMVAALRKKHADSMAE 1205

Query: 1659 LNVQISER---KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
            L  QI      K +L   K E++ E ++L      +SK K  L+ +   L+ +  EL+  
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK 1265

Query: 1716 KLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERM 1771
            + +  + +++L     + Q    E   +L+    +  Q     +   Q +E  K ++E  
Sbjct: 1266 EEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325

Query: 1772 TAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNV 1831
            T    AL   ++    + + L+E+ +  ++  A+ +R L+ A  NS++ Q    K E + 
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA--NSEVAQWR-TKYETDA 1382

Query: 1832 RKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT 1891
             +  +EL++  +        ++   Q+ +E  EAVN+    L   +  L    +DL+   
Sbjct: 1383 IQRTEELEEAKK-------KLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1435

Query: 1892 KHQD----VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
            +  +     L  +Q    K +SEW  ++E+ Q E E  Q++ + L  E+   K+K V +E
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL--FKVKNVYEE 1493

Query: 1948 MMFQRLQKERESEESKLETSKVTLK-----EQQHQLEKELTDQKSKLDQVLSKVLAA-EE 2001
             + Q     RE++  + E S +T +     +Q H+LEK     K +++Q   ++ AA EE
Sbjct: 1494 SLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEK----IKKQVEQEKCEIQAALEE 1549

Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKE----ADSMRADFSL 2057
               +L+ EE     ++  L+Q K   SE ++++ EK  E+  L++      ++M++    
Sbjct: 1550 AEASLEHEEGKILRIQLELNQVK---SEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606

Query: 2058 ---LRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELV--- 2111
                RN  L  +KK E  +  ++  L        ++L   +     +++    ++     
Sbjct: 1607 EIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG 1666

Query: 2112 AQDNHERARRLMKELNQMQYEYTE----LKKQMANQKDLERRQMEISDAMRTLKSEVKDE 2167
             +D  E+   + +  N +Q E  E    L++   ++K  E+  ++ S+ ++ L ++    
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726

Query: 2168 IRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHI 2227
            I T  K L   + +L +++E +++ + N E   E  K+ +          +K   +  H+
Sbjct: 1727 INTK-KKLENDVSQLQSEVEEVIQESRNAE---EKAKKAITDAAMMAEELKKEQDTSAHL 1782

Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGEL 2287
                       E+++   ++    L+H + +  ++ +KG ++    L +  R+++  GE+
Sbjct: 1783 -----------ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE--GEV 1829

Query: 2288 VTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
                  ++ +   L + E  + E +   +   KN
Sbjct: 1830 ENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1863



 Score =  162 bits (410), Expect = 4e-39
 Identities = 220/1032 (21%), Positives = 444/1032 (43%), Gaps = 133/1032 (12%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHN-IDDLLQEKKSLEC 1375
            E H  EN+V  L + M  L     +E   + SK +  K ++E H   +DDL  E    E 
Sbjct: 970  EKHATENKVKNLTEEMAGL-----DETIAKLSKEK--KALQETHQQTLDDLQAE----ED 1018

Query: 1376 EVEELHRTVQKRQQQKDFIDGNVES-LMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
            +V  L +   K +QQ D ++G++E      +++E++ +  E    +++  +++ +   ++
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG---DLKLAQESTMDMEND 1075

Query: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
             ++ D  L + E E+S       N + K  D +   +Q +   +EL+ R +E    +   
Sbjct: 1076 KQQLDEKLEKKEFEIS-------NLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128

Query: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI 1554
                   +    DL +   + EEI + + +   A  +  + L+KK+E    E QKL++D+
Sbjct: 1129 RASRAKAEKQRSDLSR---ELEEISERLEEAGGATSAQVE-LNKKREA---EFQKLRRDL 1181

Query: 1555 EMAERNEDHHLQVLKESEVLLQAKRAE----LEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
            E A    +  +  L++      A+  E    L+++K ++  ++ E+ +    L    E +
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241

Query: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQL 1670
                    +AK +L++  R  E +V+E      E + L+ +L+ Q+  L  +  E   QL
Sbjct: 1242 S-------KAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL 1294

Query: 1671 ----TLIKQEIEKEEENLQVV--LRQMSKHKTELKNIL-DMLQLENHELQGLKLQHD--- 1720
                 L+ Q    ++ + Q +  L+   + +T+ KN L   LQ   H+   L+ Q++   
Sbjct: 1295 DEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ 1354

Query: 1721 ------QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE 1774
                  QR      ++VA    K E + +Q+  + ++ + +  ++L E ++  +E + A+
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEH-VEAVNAK 1413

Query: 1775 SRALQSCVECLSKEKEDLQ---------------------EKCDIWEKKLAQTKRVLAAA 1813
              +L+   + L  E EDL                      +    W++K  +T+  L A+
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473

Query: 1814 EENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSL---- 1869
            ++ S+   + L K++    +   +L+ L R+  +L  +IS + +Q+ E  + ++ L    
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533

Query: 1870 ---QEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQ 1926
               ++E   +Q  L  A+  L H    +  +L  Q  L +  SE   +    +K+EE  Q
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEH---EEGKILRIQLELNQVKSEVDRKI--AEKDEEIDQ 1588

Query: 1927 QQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQK 1986
                     ++ N  ++V  E M   L  E  S    L   K        ++E +L + +
Sbjct: 1589 ---------LKRNHTRVV--ETMQSTLDAEIRSRNDALRVKK--------KMEGDLNEME 1629

Query: 1987 SKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK 2046
             +L+   +  LAAE  +R  +  +   +  +  L    R   + ++QL         LQ 
Sbjct: 1630 IQLNH--ANRLAAES-LRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQA 1686

Query: 2047 EADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMA 2106
            E + + A       Q    RK AE+++    E +++  +Q    +  +K+  + + +  +
Sbjct: 1687 EIEELWATL----EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQS 1742

Query: 2107 TIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD 2166
             +E V Q++     +  K +        ELKK+      LER +  +   ++ L+  + +
Sbjct: 1743 EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1802

Query: 2167 EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVH 2226
              + +LK   + + +L A       R   LEGE+E+ ++     + +G  + +    ++ 
Sbjct: 1803 AEQLALKGGKKQIQKLEA-------RVRELEGEVENEQKRNAEAV-KGLRKHERRVKELT 1854

Query: 2227 IMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGE 2286
               E  R   LR  L+   D+L+A+++    +QAE   + + Q+   L   R+    L E
Sbjct: 1855 YQTEEDRKNVLR--LQDLVDKLQAKVK-SYKRQAE---EAEEQSNANLSKFRKLQHELEE 1908

Query: 2287 LVTSTSADSASS 2298
                  AD A S
Sbjct: 1909 --AEERADIAES 1918



 Score =  154 bits (388), Expect = 1e-36
 Identities = 208/1024 (20%), Positives = 442/1024 (43%), Gaps = 172/1024 (16%)

Query: 1443 AEAESELSCTKE---KTKNAVEKFTDAKRSLLQTE-----SDAEELERRAQETAVNLVKA 1494
            AE E E++  KE   KTK+ + K ++AKR  L+ +      +  +L+ + Q  A +L  A
Sbjct: 846  AETEKEMATMKEEFQKTKDELAK-SEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904

Query: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI 1554
            +++        + L ++KI+ E  +KE+ +    ++     L+ KK KL +E  +L+KDI
Sbjct: 905  EER-------CEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957

Query: 1555 EMAE-----------------RNEDHHLQVLKESEVLLQAKRAELEKLKSQ----VTSQQ 1593
            +  E                 +N    +  L E+   L  ++  L++   Q    + +++
Sbjct: 958  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017

Query: 1594 QEMAVLDRQLGHKKEELHLLQGSMVQ----------AKADLQEALRLGETEVTEKCNHIR 1643
             ++ +L +     ++++  L+GS+ Q          AK  L+  L+L +    +  N  +
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ 1077

Query: 1644 EVKSLLEELSFQ--------------KGELNVQISERKTQLTLIKQEIEKEEENLQVVLR 1689
            ++   LE+  F+              + +L  +I E + ++  + +EIE E  +     +
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEK 1137

Query: 1690 QMSKHKTELKNILDML---------------------QLENHELQGLKLQHDQRVSELEK 1728
            Q S    EL+ I + L                     Q    +L+   LQH+  V+ L K
Sbjct: 1138 QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRK 1197

Query: 1729 TQVAVLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
                 + E  E ++NLQ++           KQ LE++K E++  T +   L S  E +SK
Sbjct: 1198 KHADSMAELGEQIDNLQRV-----------KQKLEKEKSELKMETDD---LSSNAEAISK 1243

Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD-------Q 1840
             K +L++ C   E ++++ K      +       +   +L+    +  ++LD       Q
Sbjct: 1244 AKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQ 1303

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
            L+R K +    I  ++ QL+E+ +A N+L   L + +   +L ++      + +  L   
Sbjct: 1304 LSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1363

Query: 1901 QTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQR 1952
             ++   ++++W  ++E    Q+ EE ++      Q+LQ  +  +E    K    E   QR
Sbjct: 1364 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQR 1423

Query: 1953 LQKERESEESKLETSK---VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL--- 2006
            LQ E E     +E S      L ++Q   +K L++ K K ++  +++ A+++  R+L   
Sbjct: 1424 LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483

Query: 2007 --------QEEERWCESLEKTLSQTKRQLSEREQQLVE---KSGELLALQKEADSMRADF 2055
                    +E     E+L +     ++++S+  +Q+ E   +  EL  ++K+ +  + + 
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543

Query: 2056 SLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI------- 2108
                 +     +  E ++  ++  L   +S++++ + E+ +E   +++    +       
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST 1603

Query: 2109 ---ELVAQDNHERARRLMK-ELNQMQYEYT--------ELKKQMANQKDLERRQMEISDA 2156
               E+ ++++  R ++ M+ +LN+M+ +           L+     Q  L+  Q+ + DA
Sbjct: 1604 LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663

Query: 2157 MRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NLPFT 2210
            +R  + ++K+++    +  N    E+  +L A LE+ E      E EL    E   L  T
Sbjct: 1664 LRG-QEDLKEQLAIVERRANLLQAEI-EELWATLEQTERSRKIAEQELLDASERVQLLHT 1721

Query: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAEV-- 2262
             N      K       +       E + ++ R+ E++ K      A +   + K+ +   
Sbjct: 1722 QNTSLINTKKKLEN-DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA 1780

Query: 2263 -LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQEK 2320
             L + K+  E T+  L+ ++D   +L     A       + +LE+ + E + ++   Q++
Sbjct: 1781 HLERMKKNLEQTVKDLQHRLDEAEQL-----ALKGGKKQIQKLEARVRELEGEVENEQKR 1835

Query: 2321 NASA 2324
            NA A
Sbjct: 1836 NAEA 1839



 Score =  117 bits (292), Expect = 2e-25
 Identities = 194/911 (21%), Positives = 366/911 (40%), Gaps = 147/911 (16%)

Query: 245  RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSK-------QTRFL 297
            R+   LEG     Q+     E     + ++L+  LEKK  E   L SK       + +  
Sbjct: 1053 RAKRKLEGDLKLAQESTMDMEN----DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108

Query: 298  EEIKNQDKLNKSLKEEAMLQKQS---CEELKSDLNTKNELLKQKTIELTRACQKQYEL-- 352
            ++IK      + L EE   ++ S    E+ +SDL+ + E + ++  E   A   Q EL  
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168

Query: 353  EQELAFYKI--DAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQA 410
            ++E  F K+  D +   L +     A   K  D    +G+              ID+ Q 
Sbjct: 1169 KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ-------------IDNLQR 1215

Query: 411  VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSELHDEIEKAEQQILR 469
            V+ K  +   +L+ +  +L  +    ++ +   EK   + + ++SEL  + E+ ++ I  
Sbjct: 1216 VKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIND 1275

Query: 470  ATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK 529
             T +  +L+        +EAG+    +QL  +  LV++L +       Q+E+ K ++  +
Sbjct: 1276 LTAQRARLQ--------TEAGE--YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325

Query: 530  QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
             K    L  A+ S                      D++ +QY++ +    E+   ++K  
Sbjct: 1326 TKAKNALAHALQS-----------------SRHDCDLLREQYEEEQEGKAELQRALSKAN 1368

Query: 590  EEIKDLEEQLTEGQIAANEAL---KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
             E+     +     I   E L   KK L   +   +E++  +  +    +   ++L++E 
Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEV 1428

Query: 647  ETLLQRLTEVEQERDQLEIVAMDAE--NMRKELAELESALQE-QHEVNASLQQTQG---- 699
            E L+     ++ ER      A+D +  N  K L+E +   +E Q E+ AS ++++     
Sbjct: 1429 EDLM-----LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483

Query: 700  ---DLSAYEAELEARLNLRDAEANQLKE----------------ELEKVTRLTQLEQSAL 740
                 + YE  L+    LR    N  +E                ELEK+ +  + E+  +
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543

Query: 741  QAELEKERQALKNALGK-AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
            QA LE+   +L++  GK  +   E  Q  SE+  K+    ++ + LK+        +   
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST 1603

Query: 800  VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
            +D  +R    A RV + + +  L   E+ ++  + +  +SL +  +    IL  ++   D
Sbjct: 1604 LDAEIRSRNDALRVKK-KMEGDLNEMEIQLNHANRLAAESLRN-YRNTQGILKETQLHLD 1661

Query: 860  EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
            +A   +  L+E++A+                               E R   ++ EI  L
Sbjct: 1662 DALRGQEDLKEQLAIV------------------------------ERRANLLQAEIEEL 1691

Query: 920  QENLKSMEEIQGLTDLQLQEADEEKERILAQLREL-EKKKKLEDAKSQ-----EQVFGLD 973
               L+  E  + + + +L +A E  + +  Q   L   KKKLE+  SQ     E+V    
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES 1751

Query: 974  KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA-----EELQEAERFSRK 1028
            +  ++  K   T   +   EL   K+Q  S H   MK N E+        L EAE+ + K
Sbjct: 1752 RNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1809

Query: 1029 AAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQR 1088
              +  + + + EA +  L+      GE    +        G       +++L    E  R
Sbjct: 1810 GGK--KQIQKLEARVRELE------GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1861

Query: 1089 TEIARLQNVLD 1099
              + RLQ+++D
Sbjct: 1862 KNVLRLQDLVD 1872



 Score =  115 bits (288), Expect = 5e-25
 Identities = 210/1014 (20%), Positives = 404/1014 (39%), Gaps = 164/1014 (16%)

Query: 213  KLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLES----LEGQPVTTQDRQEAFERFS 268
            K+KPL   +     E  + T+    Q T   L   E+    LE + VT    +   +   
Sbjct: 838  KIKPL---LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894

Query: 269  LEEVERL---ERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELK 325
              E + L   E   E+ +    +L++K     E  + ++++N  L  +    +  C ELK
Sbjct: 895  QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK 954

Query: 326  SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDES 385
             D++          +ELT A   + E E+     K+    E       E A +D+     
Sbjct: 955  KDID---------DLELTLA---KVEKEKHATENKVKNLTE-------EMAGLDET---- 991

Query: 386  PYIGK-SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK 444
              I K S+ K+ +  T    +D  QA                             EDK  
Sbjct: 992  --IAKLSKEKKALQETHQQTLDDLQAE----------------------------EDKVN 1021

Query: 445  KISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRL 502
             ++ A+T+L +  D++E + +Q  +   + ++ +  ++  LK   E+  D+     + + 
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM----ENDKQ 1077

Query: 503  QLVNKLRQEALDLELQMEKQKQEIAGK---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSG 559
            QL  KL ++  ++   + K + E A +   QK+IK+LQ  I+ L  +       +A ++ 
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE---RASRAK 1134

Query: 560  KEQQLDIMNKQYQQLESRLDEILSRIAKETE-------EIKDLEEQLTEGQI---AANEA 609
             E+Q   ++++ +++  RL+E     + + E       E + L   L E  +   A   A
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194

Query: 610  LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMD 669
            L+K     ++ L E +  ++    + + E  +L+ E + L      + + +  LE +   
Sbjct: 1195 LRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRS 1254

Query: 670  AENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV 729
             E+   +++EL++  +EQ  +   L   +  L     E   +L+ +DA  +QL    +  
Sbjct: 1255 LED---QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311

Query: 730  TRLTQLEQSALQAELEKERQALKNALGKA-------------QFSEEKE----------Q 766
            T+  Q+E+  L+ +LE+E +A KNAL  A             Q+ EE+E          +
Sbjct: 1312 TQ--QIEE--LKHQLEEETKA-KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366

Query: 767  ENSELH-----------AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDE 815
             NSE+             + + L++    L Q+L++ + H+  V       E+   R+  
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426

Query: 816  LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQ 875
                L L          S+    +L   Q+ F ++L+  K + +E Q      Q+E    
Sbjct: 1427 EVEDLMLDV------ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL 1480

Query: 876  QEKLATGQEEFRQACERALEARMNFDKRQHE-----ARIQQMENEIHYLQENLKSMEEIQ 930
              +L   +  + ++ ++    R      Q E      +I +   +IH L++  K +E+ +
Sbjct: 1481 STELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540

Query: 931  GLTDLQLQEA----DEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATS 986
                  L+EA    + E+ +IL    EL + K   D K  E+   +D+  +   + V T 
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETM 1600

Query: 987  DKLATAELTIAKDQL---KSLHGTV--MKINQERAEE---------------LQEAERFS 1026
                 AE+    D L   K + G +  M+I    A                 L+E +   
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHL 1660

Query: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETME 1085
              A +   DL    A +E   NLL+ + E+    +E+T      A  ++L+  +  + + 
Sbjct: 1661 DDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLH 1720

Query: 1086 RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKR 1139
             Q T +   +  L+   S  +   E V++E      +        + MA+  K+
Sbjct: 1721 TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKK 1774



 Score =  108 bits (269), Expect = 8e-23
 Identities = 148/720 (20%), Positives = 317/720 (44%), Gaps = 107/720 (14%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
            NLE     LED +  LK+K+ E++ +      + ++ Q+E     ++++E    +  L +
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306

Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVES------LMTE---------LEIEKSL-K 1412
             K++   ++EEL   +++  + K+ +   ++S      L+ E          E++++L K
Sbjct: 1307 SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366

Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLA----EAE----------SELSCTKEKTKN 1458
             + ++       E   ++R  EL EA + LA    EAE          + L  TK++ +N
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426

Query: 1459 AVEKFT-DAKRSLLQT----------ESDAEELERRAQETAVNLVKADQQLRSLQAD--- 1504
             VE    D +RS              +    E +++ +ET   L  + ++ RSL  +   
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK 1486

Query: 1505 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
             K++ +  + Q E L+  NK +  + SD      +  K   EL+K++K +E     E   
Sbjct: 1487 VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ----EKCE 1542

Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
            +Q  L+E+E  L+ +  ++ +++ ++   + E+   DR++  K EE+  L+ +  +    
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHTRVVET 1599

Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
            +Q  L   + E+  + + +R  K +   L E+  Q    N   +E        +  +++ 
Sbjct: 1600 MQSTL---DAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKET 1656

Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK 1737
            + +L   LR     K +L  +    ++LQ E  EL    L+  +R  ++ + ++    E+
Sbjct: 1657 QLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWAT-LEQTERSRKIAEQELLDASER 1715

Query: 1738 LELENLQQISQ-QQKGEIEWQKQLLERDKREI--ERMTAESRALQSCVECLS-----KEK 1789
            ++L + Q  S    K ++E     L+ +  E+  E   AE +A ++  +        K++
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE 1775

Query: 1790 EDLQEKCDIWEKKLAQTKRVLA-----AAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
            +D     +  +K L QT + L      A +   K  +  ++KLE  VR+L+ E++     
Sbjct: 1776 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN---- 1831

Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
                         + +   EAV  L++    V++     ++D  +  + QD++     +L
Sbjct: 1832 -------------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLV----DKL 1874

Query: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
            Q  +  +  + E+ +++      + + LQ+E+EE + +    E    +L+ +     +K+
Sbjct: 1875 QAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934



 Score =  105 bits (262), Expect = 5e-22
 Identities = 122/625 (19%), Positives = 255/625 (40%), Gaps = 73/625 (11%)

Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
            S + + E+   K+  ++ K E+ +  A+ + L+  +  L KEK DLQ             
Sbjct: 845  SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904

Query: 1794 -EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
             E+C+   K   Q +  +    E ++ E+    +L    RKL+ E  +L +D   L   +
Sbjct: 905  EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964

Query: 1853 SAMQQQLQEKREAVNSLQEELANVQDHL-NLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911
            + ++++       V +L EE+A + + +  L+K+       HQ  L         D+   
Sbjct: 965  AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL--------DDLQAE 1016

Query: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
             ++     K +   +QQ+  L+  +E+ K    +  M  +R +++ E +    + S + +
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEK----KLRMDLERAKRKLEGDLKLAQESTMDM 1072

Query: 1972 KEQQHQLEKELTDQKSKLDQVLSKV-------LAAEERVRTLQ----------EEERWCE 2014
            +  + QL+++L  ++ ++  ++SK+       +  +++++ LQ          E ER   
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132

Query: 2015 S-LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQV 2073
            +  EK  S   R+L E  ++L E  G   A  +      A+F  LR        + E  V
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192

Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
            A+L++      ++L + +   ++    ++KE + +++   D    A  + K    ++   
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252

Query: 2134 TELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQ---FLPELPADLEAIL 2190
              L+ Q++  K  E  Q  + + +   ++ ++ E     + L++    + +L    +A  
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312

Query: 2191 ERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKA 2250
            ++ E L+ +LE               E K   +  H +        L  +    E   KA
Sbjct: 1313 QQIEELKHQLEE--------------ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1358

Query: 2251 QLRHCMSK-QAEV----------LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSP 2299
            +L+  +SK  +EV           I+   + E     L +++    E V + +A  AS  
Sbjct: 1359 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLE 1418

Query: 2300 SLSQLESSLTEDSQLGQNQEKNASA 2324
               Q   +  ED  L   +   A A
Sbjct: 1419 KTKQRLQNEVEDLMLDVERSNAACA 1443



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 157/718 (21%), Positives = 319/718 (44%), Gaps = 107/718 (14%)

Query: 245  RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK-KMIETEELKSKQTRFLEEIKNQ 303
            R +  L  Q    Q     + R  L+E + L   L + K   T++++  + +  EE K +
Sbjct: 1271 RLINDLTAQRARLQTEAGEYSR-QLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAK 1329

Query: 304  DKLNKSL----------KEEAMLQKQSCEELKSDLNTKN-ELLKQKTIELTRACQKQYEL 352
            + L  +L          +E+   +++   EL+  L+  N E+ + +T   T A Q+  EL
Sbjct: 1330 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1389

Query: 353  EQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID-----S 407
            E+  A  K+  + +       E+ E   A   S    K R +  +   E  ++D     +
Sbjct: 1390 EE--AKKKLAQRLQEAE----EHVEAVNAKCASLEKTKQRLQNEV---EDLMLDVERSNA 1440

Query: 408  AQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI 467
            A A   KK    +++ ++       T    +LE  +K+  +  T L ++ +  E++  Q+
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQKYEET--QAELEASQKESRSLSTELFKVKNVYEESLDQL 1498

Query: 468  LRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQE 525
                 E K L++ I    ++I+E GK     Q+    ++  ++ QE  +++  +E+ +  
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGK-----QIHELEKIKKQVEQEKCEIQAALEEAEAS 1553

Query: 526  IAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY----QQLESRLD-E 580
            +  ++ +I  +Q+ ++ + S+      +  + + K++++D + + +    + ++S LD E
Sbjct: 1554 LEHEEGKILRIQLELNQVKSE------VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAE 1607

Query: 581  ILSR-----IAKETE-EIKDLEEQLTEGQIAANEALK--KDLEGVISGLQEYLG-TIKGQ 631
            I SR     + K+ E ++ ++E QL      A E+L+  ++ +G++   Q +L   ++GQ
Sbjct: 1608 IRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667

Query: 632  ATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVN 691
              +   E   + + +  LLQ   E+E+    LE      +   +EL +    +Q  H  N
Sbjct: 1668 --EDLKEQLAIVERRANLLQ--AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723

Query: 692  ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL 751
             SL  T+  L              + + +QL+ E+E+V       Q +  AE EK ++A+
Sbjct: 1724 TSLINTKKKL--------------ENDVSQLQSEVEEVI------QESRNAE-EKAKKAI 1762

Query: 752  KNALGKAQFSEE--KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD-----GLV 804
             +A   A  +EE  KEQ+ S       HL+     L+Q +KD Q+ L+         G  
Sbjct: 1763 TDA---AMMAEELKKEQDTSA------HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1813

Query: 805  RPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
            + +++ ARV EL  +++      N    +    K L   +++  E+     ++ +E +  
Sbjct: 1814 QIQKLEARVRELEGEVE------NEQKRNAEAVKGLRKHERRVKELT----YQTEEDRKN 1863

Query: 865  ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQEN 922
              +LQ+ +   Q K+ + + +  +A E++      F K QHE    +   +I   Q N
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVN 1921



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 98/490 (20%), Positives = 206/490 (42%), Gaps = 78/490 (15%)

Query: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
            K A+T++ +A  +E  +  +  L K E   ++L++++  L ++K    ND+     QLQ 
Sbjct: 844  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEK----NDL-----QLQV 894

Query: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
            + EA     + LA+ ++                + L+  + +L+  I E   R E+ ++ 
Sbjct: 895  QSEA-----DSLADAEERC--------------EQLIKNKIQLEAKIKEVTERAEEEEEI 935

Query: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
                  + + L++E  E K  +   E+   +++KE+ + E+K+               K 
Sbjct: 936  NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---------------KN 980

Query: 1982 LTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGEL 2041
            LT++ + LD+ ++K          L +E++   +L++T  QT   L   E ++   +   
Sbjct: 981  LTEEMAGLDETIAK----------LSKEKK---ALQETHQQTLDDLQAEEDKVNILTKAK 1027

Query: 2042 LALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCI 2101
              L+++ D +       +   +   +   K    LK A   Q S ++    +Q+ +    
Sbjct: 1028 TKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---QESTMDMENDKQQLDEKLE 1084

Query: 2102 QKEMATIELVAQDNHERA--RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT 2159
            +KE     L+++   E+A   +L K++ ++Q    EL +           ++E   A R 
Sbjct: 1085 KKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGE-----------EIEAERASRA 1133

Query: 2160 LKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNE-----G 2214
               + + ++   L+ +++ L E      A +E N+  E E + L+ +L     +      
Sbjct: 1134 KAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193

Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
               +K   S   + ++    + +++KL   +  LK +    +S  AE + K K   E   
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD-LSSNAEAISKAKGNLEKMC 1252

Query: 2275 HSLRRQVDAL 2284
             SL  QV  L
Sbjct: 1253 RSLEDQVSEL 1262



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 76/333 (22%), Positives = 141/333 (42%), Gaps = 35/333 (10%)

Query: 1993 LSKVLAAEERVRTLQEE-ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
            L K    E+ + T++EE ++  + L K+ ++ K    +    L EK+   L +Q EADS+
Sbjct: 842  LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901

Query: 2052 RADF-----SLLRNQFLTERKKAE-----KQVASLKEALKIQRSQLEKNLLEQKQENSCI 2101
             AD       L++N+   E K  E     ++   +   L  ++ +LE    E K++   +
Sbjct: 902  -ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL 960

Query: 2102 QKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLK 2161
            +  +A +E        + + L +E+  +     +L K+   +K L+    +  D ++  +
Sbjct: 961  ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKE---KKALQETHQQTLDDLQAEE 1017

Query: 2162 SEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLN 2221
             +V    +   K     L +   DLE  LE+ + L  +LE  K  L         E  L 
Sbjct: 1018 DKVNILTKAKTK-----LEQQVDDLEGSLEQEKKLRMDLERAKRKL---------EGDLK 1063

Query: 2222 FSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQV 2281
             +Q   MD     + L EKL  +E  +   +     +QA  +     Q +  +  L+ ++
Sbjct: 1064 LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEI-----QLQKKIKELQARI 1118

Query: 2282 DALGELVTSTSADSA-SSPSLSQLESSLTEDSQ 2313
            + LGE + +  A  A +    S L   L E S+
Sbjct: 1119 EELGEEIEAERASRAKAEKQRSDLSRELEEISE 1151



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 73/364 (20%), Positives = 161/364 (44%), Gaps = 50/364 (13%)

Query: 270  EEVERLERDLEKKMIET------EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323
            EE+++L+R+   +++ET       E++S+      + K +  LN+   +     + + E 
Sbjct: 1584 EEIDQLKRN-HTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES 1642

Query: 324  LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD 383
            L++  NT+  +LK+  + L  A + Q +L+++LA  +  A     N   +E  E+    +
Sbjct: 1643 LRNYRNTQG-ILKETQLHLDDALRGQEDLKEQLAIVERRA-----NLLQAEIEELWATLE 1696

Query: 384  ESPYIGKSRYKRNMFATESYIIDSAQAVQI------KKMEPDEQLRNDHMNLRGHTP-LD 436
            ++        +R+    E  ++D+++ VQ+        +   ++L ND   L+     + 
Sbjct: 1697 QT--------ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748

Query: 437  TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEA----- 489
             +  + E+K   A T  + + +E++K +          K LE+ ++    ++ EA     
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1808

Query: 490  --GKDLLYK------QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQ 537
              GK  + K      +L G ++   K   EA+    + E++ +E+  +    +K +  LQ
Sbjct: 1809 KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQ 1868

Query: 538  IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE 597
              +D L +K   +   K Q    E+Q +    ++++L+  L+E   R      ++  L  
Sbjct: 1869 DLVDKLQAKVKSY---KRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRV 1925

Query: 598  QLTE 601
            +  E
Sbjct: 1926 KSRE 1929



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 49/239 (20%), Positives = 105/239 (43%), Gaps = 28/239 (11%)

Query: 2082 IQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMA 2141
            ++ ++ EK +   K+E    + E+A  E   ++  E+   L+KE N +Q    +++ +  
Sbjct: 843  LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQSEAD 899

Query: 2142 NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELE 2201
            +  D E R  ++      L++++K+    + +       E+ A+L A   + E+   EL+
Sbjct: 900  SLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-----EEINAELTAKKRKLEDECSELK 954

Query: 2202 SLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAE 2261
               ++L  T+ +   E+    ++V  + E   G  L E +              +SK+ +
Sbjct: 955  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAK------------LSKEKK 1000

Query: 2262 VLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEK 2320
             L +  +QT   L +   +V+ L      T A +     +  LE SL ++ +L  + E+
Sbjct: 1001 ALQETHQQTLDDLQAEEDKVNIL------TKAKTKLEQQVDDLEGSLEQEKKLRMDLER 1053


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  164 bits (415), Expect = 9e-40
 Identities = 229/1053 (21%), Positives = 462/1053 (43%), Gaps = 134/1053 (12%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ +  + ++     + A KR+ E E  EL  +IDDL      +E E       V+
Sbjct: 921  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
               ++   +D  +  L  E   +K+L+  H+  +D+++  E    TL K + +L ++ D 
Sbjct: 981  NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1037

Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
            L    E E ++    E+ K  +E     A+ S +  E+D ++L+ + ++    +     +
Sbjct: 1038 LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK 1097

Query: 1498 LRSLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            +   QA    L Q KIK+ +  ++E+ + + A+ +      K++  L+ EL+++ + +E 
Sbjct: 1098 IEDEQALGMQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQQ 1594
            A       +++ K+ E   Q  R +LE+                      L  Q+ + Q+
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216

Query: 1595 EMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
                L+++    K E+  L  +M    +AK +L++  R  E +++E      E + L+ +
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276

Query: 1652 LSFQK-------GELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
            L+ Q+       GE + Q+ E+ T   QL+  KQ   ++ E L+  L +  K K+ L + 
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336

Query: 1702 L-------DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI 1754
            L       D+L+ +  E Q  K +  QR      ++VA    K E + +Q+  + ++ + 
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAEL-QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395

Query: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ---EKCDI------------- 1798
            +  ++L + ++  +E + A+  +L+   + L  E EDL    E+ +              
Sbjct: 1396 KLAQRLQDAEEH-VEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454

Query: 1799 -----WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDIS 1853
                 W++K  +T   L A+++ S+   + L K++    +   +L+ L R+  +L  +IS
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514

Query: 1854 AMQQQLQEKREAVNSLQ---EELANVQDHLNLAKQDLLHTTKHQD-VLLSEQTRLQKDIS 1909
             + +Q+ E  + ++ L+   +++   +  L  A ++   + +H++  +L  Q  L +  S
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKS 1574

Query: 1910 EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV 1969
            E   +    +K+EE  Q         ++ N +++V  E M   L  E  S    +   K 
Sbjct: 1575 EVDRKI--AEKDEEIDQ---------MKRNHIRIV--ESMQSTLDAEIRSRNDAIRLKK- 1620

Query: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSE 2029
                   ++E +L + + +L+        A E +R  +  +   +  +  L    R   +
Sbjct: 1621 -------KMEGDLNEMEIQLNHANR---MAAEALRNYRNTQAILKDTQLHLDDALRSQED 1670

Query: 2030 REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKI---QRSQ 2086
             ++QL         LQ E + +RA       Q    RK AE+++    E +++   Q + 
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASERVQLLHTQNTS 1726

Query: 2087 LEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL 2146
            L     + + + S IQ EM  I   A++  E+A++ + +   M     ELKK+      L
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMA---EELKKEQDTSAHL 1783

Query: 2147 ERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES-LKE 2205
            ER +  +   ++ L+  + +  + +LK   + + +L A       R   LEGE+ES  K 
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEA-------RVRELEGEVESEQKR 1836

Query: 2206 NLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIK 2265
            N+         E K+   ++    E  R   LR  L+   D+L+A+++    +QAE   +
Sbjct: 1837 NVEAVKGLRKHERKV--KELTYQTEEDRKNILR--LQDLVDKLQAKVK-SYKRQAE---E 1888

Query: 2266 GKRQTEGTLHSLRRQVDALGELVTSTSADSASS 2298
             + Q+   L   RR    L E      AD A S
Sbjct: 1889 AEEQSNVNLSKFRRIQHELEE--AEERADIAES 1919



 Score =  156 bits (395), Expect = 2e-37
 Identities = 201/1050 (19%), Positives = 451/1050 (42%), Gaps = 133/1050 (12%)

Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS 1410
            ++EKEM  +    +   +E    E + +EL   +    Q+K+ +         +L+++  
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL---------QLQVQAE 898

Query: 1411 LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
                 D  +  + + KT ++  ++++E     AE E E++           + T  KR L
Sbjct: 899  ADSLADAEERCDQLIKTKIQLEAKIKEVTE-RAEDEEEINA----------ELTAKKRKL 947

Query: 1471 LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
               E +  EL++   +  + L K +++  + +   K+L +     +E + ++ K   A  
Sbjct: 948  ---EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004

Query: 1531 -------SDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELE 1583
                    D Q    K   LT+   KL++ ++  E + +   ++  + E   +    +L+
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK 1064

Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG-ETEVTEKCNHI 1642
              +      + +   LD +L  K+ E+     S +Q+K + ++AL +  + ++ E    I
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEM-----SGLQSKIEDEQALGMQLQKKIKELQARI 1119

Query: 1643 REVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL 1702
             E++  +E     + +   Q S+   +L  I + +E+        +    K + E + + 
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM- 1178

Query: 1703 DMLQLENHELQGLKLQHDQRVSELEKTQV-AVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
                    +L+   LQH+   + L K    +V E   +++NLQ++           KQ L
Sbjct: 1179 ------RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV-----------KQKL 1221

Query: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
            E++K E   M  E   L S +E +SK K +L++ C   E +L++ K      +       
Sbjct: 1222 EKEKSE---MKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278

Query: 1822 SNLEKLELNVRKLQQELD-------QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELA 1874
            +   +L+    +  ++LD       QL+R K +    I  +++QL+E+ +A ++L   L 
Sbjct: 1279 AQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQ 1338

Query: 1875 NVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED--CQKEEETKQ------ 1926
            + +   +L ++      + +  L    ++   ++++W  ++E    Q+ EE ++      
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398

Query: 1927 QQLQVLQNEIEENKLKLVQQEMMFQRLQKERES---EESKLETSKVTLKEQQHQLEKELT 1983
            Q+LQ  +  +E    K    E   QRLQ E E    +  +   +   L ++Q   +K L 
Sbjct: 1399 QRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILA 1458

Query: 1984 DQKSKLDQVLSKVLAAEERVRTL-----------QEEERWCESLEKTLSQTKRQLSEREQ 2032
            + K K ++  +++ A+++  R+L           +E     E+L++     ++++S+  +
Sbjct: 1459 EWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1518

Query: 2033 QLVE---KSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEK 2089
            Q+ E   +  EL  ++K+ +  +++      +     +  E ++  ++  L   +S++++
Sbjct: 1519 QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1578

Query: 2090 NLLEQKQENSCIQKEMATI----------ELVAQDNHERARRLMK-ELNQMQYEYTELKK 2138
             + E+ +E   +++    I          E+ ++++  R ++ M+ +LN+M+ +     +
Sbjct: 1579 KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638

Query: 2139 QMA--------NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAIL 2190
              A         Q  L+  Q+ + DA+R+ + ++K+++    +  N    E+  +L A L
Sbjct: 1639 MAAEALRNYRNTQAILKDTQLHLDDALRS-QEDLKEQLAMVERRANLLQAEI-EELRATL 1696

Query: 2191 ERNEN----LEGELESLKE--NLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHR 2244
            E+ E      E EL    E   L  T N      K    +  I       E + ++ R+ 
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL-ETDISQIQGEMEDIIQEARNA 1755

Query: 2245 EDRLK------AQLRHCMSKQAEV---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADS 2295
            E++ K      A +   + K+ +    L + K+  E T+  L+ ++D   +L     A  
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL-----ALK 1810

Query: 2296 ASSPSLSQLESSLTE-DSQLGQNQEKNASA 2324
                 + +LE+ + E + ++   Q++N  A
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESEQKRNVEA 1840



 Score =  121 bits (304), Expect = 7e-27
 Identities = 174/859 (20%), Positives = 366/859 (42%), Gaps = 144/859 (16%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRAS--KRQSE--KEMEELHHNIDDL-------LQE 1369
            L+ ++  L+  ++ L+ +   ER  RA   K++S+  +E+EE+   +++        ++ 
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167

Query: 1370 KKSLECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSL 1411
             K  E E +++ R +++            R++  D +        N++ +  +LE EKS 
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1227

Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
               E  +D++    +T+ K +  L +  R L +  SE+   +E+ +  +   T A+R+ L
Sbjct: 1228 MKME--IDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT-AQRARL 1284

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
            QTES     +   ++T V+     Q  R  QA  + +E+ K + EE +K  + +  A  S
Sbjct: 1285 QTESGEYSRQLDEKDTLVS-----QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQS 1339

Query: 1532 ---DFQCLSKKKEKLTEELQKLQKDI-----EMAERNEDHHLQVLKESEVLLQAKRAELE 1583
               D   L ++ E+  E   +LQ+ +     E+A+    +    ++ +E L +AK+    
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK---- 1395

Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1643
            KL  ++   ++ +  ++ +    ++    LQ  +     D++           ++ N  +
Sbjct: 1396 KLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDK 1455

Query: 1644 EVKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
             +    ++      EL     E +   T+L  IK   E+  + L+ + R+    + E+ +
Sbjct: 1456 ILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1515

Query: 1701 ILDMLQLEN---HELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGE 1753
            + + +       HEL+ +K Q +Q  SEL    E+ + ++  E+ ++  +Q    Q K E
Sbjct: 1516 LTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1575

Query: 1754 IEWQKQLLERDKREIERMT---------------AESRALQSCVECLSKEKEDLQEKCDI 1798
            ++  +++ E+D+ EI++M                AE R+    +    K + DL E    
Sbjct: 1576 VD--RKIAEKDE-EIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM--- 1629

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
             E +L    R+ A A  N +  Q+ L+  +L+       LD   R +  L   ++ ++++
Sbjct: 1630 -EIQLNHANRMAAEALRNYRNTQAILKDTQLH-------LDDALRSQEDLKEQLAMVERR 1681

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEW 1911
                +  +  L+  L   +    +A+Q+LL  ++   +L ++ T       +L+ DIS+ 
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741

Query: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSK 1968
                ED           +Q  +N  E+ K  +    MM + L+KE+++    E   +  +
Sbjct: 1742 QGEMEDI----------IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1791

Query: 1969 VTLKEQQHQLEKE----LTDQKSKLDQVLSKVLAAE-----------ERVRTLQEEER-- 2011
             T+K+ QH+L++     L   K ++ ++ ++V   E           E V+ L++ ER  
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKV 1851

Query: 2012 -------------------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMR 2052
                                 + L+  +   KRQ  E E+Q      +   +Q E +   
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911

Query: 2053 ADFSLLRNQFLTERKKAEK 2071
                +  +Q    R K+ +
Sbjct: 1912 ERADIAESQVNKLRVKSRE 1930



 Score =  117 bits (292), Expect = 2e-25
 Identities = 181/906 (19%), Positives = 373/906 (41%), Gaps = 122/906 (13%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDK-LNKSLKEEAMLQK---QSCEELK 325
            ++++ LE  L K   E    ++K     EE+   D+ + K  KE+  LQ+   Q+ ++L+
Sbjct: 956  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015

Query: 326  SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDES 385
            ++ +  N L K K     +    +  LEQE    KI    E                   
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK---KIRMDLE------------------- 1053

Query: 386  PYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKK 445
                  R KR +        +S   ++  K + DE+L+     + G   L +++ED++  
Sbjct: 1054 ------RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG---LQSKIEDEQAL 1104

Query: 446  ISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLV 505
                Q ++ EL   IE              +LEE I+ ++ S A  +     LS  L+ +
Sbjct: 1105 GMQLQKKIKELQARIE--------------ELEEEIEAERASRAKAEKQRSDLSRELEEI 1150

Query: 506  NKLRQEALD-LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL 564
            ++  +EA      Q+E  K+  A  QK  +DL+         +    H     + +++  
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLE---------EATLQHEATAATLRKKHA 1201

Query: 565  DIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY 624
            D + +  +Q+++ L  +  ++ KE  E+K   + L       ++A K +LE +   L++ 
Sbjct: 1202 DSVAELGEQIDN-LQRVKQKLEKEKSEMKMEIDDLASNMETVSKA-KGNLEKMCRALEDQ 1259

Query: 625  LGTIKGQATQAQ-----------------NECRKLRDEKETLLQRLTEVEQE-RDQLEIV 666
            L  IK +  + Q                  E  +  DEK+TL+ +L+  +Q    Q+E +
Sbjct: 1260 LSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319

Query: 667  AMDAENMRKELAELESALQ-EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE 725
                E   K  + L  ALQ  +H+ +   +Q       YE E EA+  L+ A +   K  
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQ-------YEEEQEAKAELQRAMS---KAN 1369

Query: 726  LEKVTRLTQLEQSALQ--AELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNN 783
             E     T+ E  A+Q   ELE+ ++ L      AQ  ++ E+    ++AK   L+    
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKL------AQRLQDAEEHVEAVNAKCASLEKTKQ 1423

Query: 784  LLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
             L+ +++D    +          ++     D++  + K    E   H+  +   K    L
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEE--THAELEASQKESRSL 1481

Query: 844  QKQFSEILARSKWERDEAQVRERK---LQEEMALQQEKLATGQEEFRQACERALEARMNF 900
              +  +I    +   D+ +  +R+   LQ+E++   E++A G +   +     ++ ++  
Sbjct: 1482 STELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--EKIKKQVEQ 1539

Query: 901  DKRQHEARIQQMENEIHYLQENL----KSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
            +K + +A +++ E  + + +  +      + +++   D ++ E DEE +++        K
Sbjct: 1540 EKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQM--------K 1591

Query: 957  KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA--TAELTIAKDQLKSLHGTVMKINQE 1014
            +  +   +S +    LD E++    A+    K+     E+ I  +    +    ++  + 
Sbjct: 1592 RNHIRIVESMQST--LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1649

Query: 1015 RAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG-ANSQ 1073
                L++ +     A ++  DL    A +E   NLL+ + E+ R  +E+T      A  +
Sbjct: 1650 TQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1709

Query: 1074 VLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
            +L+  +  + +  Q T +   +  L+   S  +G  E++++E      +        + M
Sbjct: 1710 LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMM 1769

Query: 1134 ADPFKR 1139
            A+  K+
Sbjct: 1770 AEELKK 1775



 Score =  110 bits (275), Expect = 2e-23
 Identities = 145/709 (20%), Positives = 312/709 (44%), Gaps = 98/709 (13%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
            NLE     LED +  +K+K+ E++ +      + ++ Q+E     ++++E    +  L +
Sbjct: 1248 NLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307

Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVES------LMTE---------LEIEKSL-K 1412
             K++   ++EEL R +++  + K  +   ++S      L+ E          E+++++ K
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367

Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLAE----AE----------SELSCTKEKTKN 1458
             + ++       E   ++R  EL EA + LA+    AE          + L  TK++ +N
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427

Query: 1459 AVEKF------TDAKRSLLQTESD-----AEELERRAQETAVNLVKADQQLRSLQADA-- 1505
             VE        T+A  + L  +         E +++ +ET   L  + ++ RSL  +   
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487

Query: 1506 -KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
             K+  +  + Q E LK  NK +  + SD      +  K   EL+K++K +E     E   
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKSE 1543

Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
            LQ  L+E+E  L+ +  ++ +++ ++   + E+   DR++  K EE+  ++ + ++    
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQMKRNHIRIVES 1600

Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
            +Q  L   + E+  + + IR  K +   L E+  Q    N   +E        +  ++  
Sbjct: 1601 MQSTL---DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657

Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGL--KLQHDQRVSELEKTQVAVLE 1735
            + +L   LR     K +L  +    ++LQ E  EL+    + +  ++++E E    +   
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1717

Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKE 1790
            + L  +N   I+ ++K E +  +   E +    E   AE +A ++  +        K+++
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777

Query: 1791 DLQEKCDIWEKKLAQTKRVLA-----AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
            D     +  +K L QT + L      A +   K  +  ++KLE  VR+L+ E++   +  
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837

Query: 1846 LSL-------HNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
            +            +  +  Q +E R+ +  LQ+ +  +Q  +   K+      +  +V L
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897

Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
            S+  R+Q ++       E+ ++  +  + Q+  L+ +  E   K++ +E
Sbjct: 1898 SKFRRIQHEL-------EEAEERADIAESQVNKLRVKSREVHTKIISEE 1939



 Score =  108 bits (271), Expect = 5e-23
 Identities = 226/1051 (21%), Positives = 425/1051 (40%), Gaps = 138/1051 (13%)

Query: 85   EALIKKLTKQDNLALIKS----LNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKI 140
            E   KK   +D  + +K     L L+L+K        +E  +   + +V NL+  + G  
Sbjct: 939  ELTAKKRKLEDECSELKKDIDDLELTLAK--------VEKEKHATENKVKNLTEEMAGLD 990

Query: 141  EKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNL 200
            E + KL K ++     ++       + + +LQ      N +    + L +++  L     
Sbjct: 991  ETIAKLTKEKKALQEAHQ-------QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1043

Query: 201  KGNKISSLQDISKLKPLQDLI----SLILVENPVVTLPHYLQFTIFHLRSLES-LEGQPV 255
            +  KI    + +K K   DL     S + +EN    L   L+   F +  L+S +E +  
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQA 1103

Query: 256  TTQDRQEAFERFSLEEVERLERDLEKKMI---ETEELKSKQTRFLEEIKN---------- 302
                 Q+  +      +E LE ++E +     + E+ +S  +R LEEI            
Sbjct: 1104 LGMQLQKKIKELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162

Query: 303  -QDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQK----TIELTRACQKQYELEQELA 357
             Q ++NK  + E    ++  EE           L++K      EL         ++Q+L 
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222

Query: 358  FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKME 417
              K + K E ++   S    + KA        K   ++   A E       Q  +IK  E
Sbjct: 1223 KEKSEMKME-IDDLASNMETVSKA--------KGNLEKMCRALED------QLSEIKTKE 1267

Query: 418  PDEQ-LRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFK- 475
             ++Q L ND    R    L T+  +  +++    T +S+L     + +Q   +  EE K 
Sbjct: 1268 EEQQRLINDLTAQRAR--LQTESGEYSRQLDEKDTLVSQL----SRGKQAFTQQIEELKR 1321

Query: 476  QLEEAIQLKKI-------SEAGKDLLYKQLSGRLQLVNKLRQEA-LDLELQMEKQKQEIA 527
            QLEE I+ K         S    DLL +Q            QEA  +L+  M K   E+A
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEE--------QEAKAELQRAMSKANSEVA 1373

Query: 528  GKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAK 587
              Q   K    AI   +  +     +  +    E+ ++ +N +   LE    +   R+  
Sbjct: 1374 --QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE----KTKQRLQN 1427

Query: 588  ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKE 647
            E E++  ++ + T    AA +  +++ + +++  ++       +   +Q E R L  E  
Sbjct: 1428 EVEDLM-IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTE-- 1484

Query: 648  TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ----HE---VNASLQQTQGD 700
             L +     E+  DQLE +  + +N+++E+++L   + E     HE   +   ++Q + +
Sbjct: 1485 -LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543

Query: 701  LSAYEAELEARLNLRDA-------EANQLKEELEKVT---------------RLTQLEQS 738
            L A   E EA L   +        E NQ+K E+++                 R+ +  QS
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603

Query: 739  ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQ--LKDFQNHL 796
             L AE+     A++  L K    +  E E    HA     +   N    Q  LKD Q HL
Sbjct: 1604 TLDAEIRSRNDAIR--LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL 1661

Query: 797  NHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK-QFSEILARSK 855
            +  +      +E  A V+     L+    E+          + +A+ +    SE +    
Sbjct: 1662 DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1721

Query: 856  WERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ---- 911
             +       ++KL+ +++  Q ++    +E R A E+A +A  +      E + +Q    
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1781

Query: 912  -MENEIHYLQENLKSMEE-IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQV 969
             +E     L++ +K ++  +     L L+   ++ +++ A++RELE + + E  ++ E V
Sbjct: 1782 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAV 1841

Query: 970  FGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFS-RK 1028
             GL K  +K+K+    +++     L + +D +  L   V K  + +AEE +E    +  K
Sbjct: 1842 KGLRKHERKVKELTYQTEEDRKNILRL-QDLVDKLQAKV-KSYKRQAEEAEEQSNVNLSK 1899

Query: 1029 AAQAARDLTRAEAEIELLQ---NLLRQKGEQ 1056
              +   +L  AE   ++ +   N LR K  +
Sbjct: 1900 FRRIQHELEEAEERADIAESQVNKLRVKSRE 1930



 Score =  103 bits (257), Expect = 2e-21
 Identities = 130/624 (20%), Positives = 253/624 (40%), Gaps = 71/624 (11%)

Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
            S + + E+   K+  E+ K E+ +  A+ + L+  +  L +EK DLQ             
Sbjct: 846  SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905

Query: 1794 -EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
             E+CD   K   Q +  +    E ++ E+    +L    RKL+ E  +L +D   L   +
Sbjct: 906  EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965

Query: 1853 SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWA 1912
            + ++++       V +L EE+A + +   +AK      TK +  L     +   D+    
Sbjct: 966  AKVEKEKHATENKVKNLTEEMAGLDE--TIAK-----LTKEKKALQEAHQQTLDDLQAEE 1018

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ---KERESEESKLETSKV 1969
            ++     K +   +QQ+  L+  +E+ K   +  E   ++L+   K  +     +E  K 
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQ 1078

Query: 1970 TLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEE---ERWCES-LEK 2018
             L E+  + E E++  +SK++       Q+  K+   + R+  L+EE   ER   +  EK
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEK 1138

Query: 2019 TLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQF-----------LTERK 2067
              S   R+L E  ++L E  G   A  +      A+F  +R               T RK
Sbjct: 1139 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198

Query: 2068 KAEKQVASLKEAL-KIQR--SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMK 2124
            K    VA L E +  +QR   +LEK   E K E   +   M T+     +  +  R L  
Sbjct: 1199 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED 1258

Query: 2125 ELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKN----LNQFLP 2180
            +L++++ +  E ++++ N    +R +++      + + + KD + + L        Q + 
Sbjct: 1259 QLSEIKTKEEE-QQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIE 1317

Query: 2181 ELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK 2240
            EL   LE  ++    L   L+S + +      +  +EE+               +  + +
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ--YEEE---------------QEAKAE 1360

Query: 2241 LRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPS 2300
            L+    +  +++    +K     I+   + E     L +++    E V + +A  AS   
Sbjct: 1361 LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420

Query: 2301 LSQLESSLTEDSQLGQNQEKNASA 2324
              Q   +  ED  +   +   A A
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACA 1444



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 155/720 (21%), Positives = 313/720 (43%), Gaps = 121/720 (16%)

Query: 510  QEALDLELQMEKQKQEIA---GKQKEIKDLQIAIDSLDSKDPKHSHMKAQK---SGKEQQ 563
            +E  +++ + EK K+E+A    K+KE+++  + +  +  K+     ++A+    +  E++
Sbjct: 851  KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTL--MQEKNDLQLQVQAEADSLADAEER 908

Query: 564  LDIMNKQYQQLESRLDEILSRIAKETE---------------------EIKDLEEQL--T 600
             D + K   QLE+++ E+  R   E E                     +I DLE  L   
Sbjct: 909  CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 968

Query: 601  EGQIAANEALKKDLEGVISGLQEYLGTIKGQA-------TQAQNECRKLRDEKETLLQRL 653
            E +  A E   K+L   ++GL E +  +  +         Q  ++ +   D+  TL +  
Sbjct: 969  EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028

Query: 654  TEVEQERDQLE-------IVAMDAENMRKEL-AELESALQEQHEVNASLQQTQGDLSAYE 705
             ++EQ+ D LE        + MD E  +++L  +L+ A +   ++    QQ    L   E
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE 1088

Query: 706  AE---LEARLNLRDAEANQLKEELEKV-TRLTQLEQS-----ALQAELEKERQALKNALG 756
             E   L++++    A   QL+++++++  R+ +LE+      A +A+ EK+R  L   L 
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL- 1147

Query: 757  KAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA----- 811
              + SE  E+      A+++       + K++  +FQ     + +  ++ E  AA     
Sbjct: 1148 -EEISERLEEAGGATSAQIE-------MNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199

Query: 812  ----------RVDELRR---KLKLGTGEM-----NIHSPSDVLGKSLADLQKQ---FSEI 850
                      ++D L+R   KL+    EM     ++ S  + + K+  +L+K      + 
Sbjct: 1200 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQ 1259

Query: 851  LARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF-RQACER-ALEARMNFDKRQHEAR 908
            L+  K + +E Q    +L  ++  Q+ +L T   E+ RQ  E+  L ++++  K+    +
Sbjct: 1260 LSEIKTKEEEQQ----RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315

Query: 909  IQ----QMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDA- 963
            I+    Q+E EI        +++  +   DL L+E  EE++   A+L+    K   E A 
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDL-LREQYEEEQEAKAELQRAMSKANSEVAQ 1374

Query: 964  ---KSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
               K +       +EL++ KK +A   + A   +     +  SL  T  ++  E  + + 
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434

Query: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL 1080
            + ER    AA AA D  + +   + +    +QK E+   E+E +     + S   E+ K+
Sbjct: 1435 DVER--TNAACAALD--KKQRNFDKILAEWKQKCEETHAELEAS--QKESRSLSTELFKI 1488

Query: 1081 NETMERQRTEIARL--------QNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISS 1132
                E    ++  L        Q + DLT    +GG    + E+ +++++V  +   + +
Sbjct: 1489 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG--KRIHELEKIKKQVEQEKSELQA 1546



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 127/613 (20%), Positives = 258/613 (42%), Gaps = 87/613 (14%)

Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
            C++      E + ++ E  +Q   SK   E  +W    +  + +  EEL      L Q  
Sbjct: 1344 CDLLREQYEEEQEAKAE--LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401

Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
            +  E  VE ++      ++ K  +   VE LM ++E        ++K  ++ + I+ E  
Sbjct: 1402 QDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWK 1461

Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
                     +E  +K      +EL +      E+  +L   K + KN  ++ +D    + 
Sbjct: 1462 QKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1521

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAK-DLEQHKIKQ-----EEILKEINKI 1525
            +      ELE+  ++  V   K++ Q    +A+A  + E+ KI +      ++  E+++ 
Sbjct: 1522 EGGKRIHELEKIKKQ--VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1579

Query: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV-----LKESEVLLQ-AKR 1579
            +A KD +   + +   ++ E +Q    D E+  RN+   L+      L E E+ L  A R
Sbjct: 1580 IAEKDEEIDQMKRNHIRIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638

Query: 1580 AELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC 1639
               E L++   +Q    A+L      K  +LHL     ++++ DL+E L + E       
Sbjct: 1639 MAAEALRNYRNTQ----AIL------KDTQLHL--DDALRSQEDLKEQLAMVERRANLLQ 1686

Query: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
              I E+++ LE+            +ER  ++   +QE+    E +Q++  Q     T L 
Sbjct: 1687 AEIEELRATLEQ------------TERSRKIA--EQELLDASERVQLLHTQ----NTSLI 1728

Query: 1700 NILDMLQLENHELQGLK---LQHDQRVSELEK---TQVAVLEEKLELE------------ 1741
            N    L+ +  ++QG     +Q  +   E  K   T  A++ E+L+ E            
Sbjct: 1729 NTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 1742 NLQQISQQQKGEIEWQKQL-LERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
            NL+Q  +  +  ++  +QL L+  K++I+++ A  R L+  VE   K   +  +     E
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE 1848

Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
            +K+ +         +N    Q  ++KL+  V+  +++ ++         +    +Q +L+
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELE 1908

Query: 1861 EKREAVNSLQEEL 1873
            E  E  +  + ++
Sbjct: 1909 EAEERADIAESQV 1921



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 122/560 (21%), Positives = 240/560 (42%), Gaps = 75/560 (13%)

Query: 613  DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT----EVEQERDQLEIVAM 668
            + E  ++ ++E     K +  + + + ++L ++  TL+Q       +V+ E D L     
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907

Query: 669  DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL-----EARLNLRDAEANQLK 723
              + + K   +LE+ ++E  E     ++   +L+A + +L     E + ++ D E    K
Sbjct: 908  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967

Query: 724  EELE------KVTRLTQLEQSALQ---AELEKERQALKNALGKA--QFSEEKEQENSELH 772
             E E      KV  LT+ E + L    A+L KE++AL+ A  +       E+++ N+   
Sbjct: 968  VEKEKHATENKVKNLTE-EMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1026

Query: 773  AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSP 832
            AK+K        L+QQ+ D +  L          +E   R+D  R K KL  G++ +   
Sbjct: 1027 AKIK--------LEQQVDDLEGSLE---------QEKKIRMDLERAKRKL-EGDLKLAQE 1068

Query: 833  SDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACER 892
            S +    + + ++Q  E L + ++E    Q    K+++E AL  +     +E   QA   
Sbjct: 1069 STM---DIENDKQQLDEKLKKKEFEMSGLQ---SKIEDEQALGMQLQKKIKE--LQARIE 1120

Query: 893  ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLR 952
             LE  +  ++       +Q  +    L+E  + +EE  G T  Q++   + +       R
Sbjct: 1121 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180

Query: 953  ELEK------------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAK 998
            +LE+            +KK  D+ ++  EQ+  L +  +KL+K   +  K+   +L    
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEMKMEIDDLASNM 1239

Query: 999  DQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFR 1058
            + +    G + K+ +   ++L E +    +  +   DLT   A ++       + GE  R
Sbjct: 1240 ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ------TESGEYSR 1293

Query: 1059 LEMEK----TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFEN 1111
               EK    + +  G  +   +IE+L   +E +    + L + L  +  D    +  +E 
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353

Query: 1112 VLEEIAELRREVSYQNDYIS 1131
              E  AEL+R +S  N  ++
Sbjct: 1354 EQEAKAELQRAMSKANSEVA 1373



 Score = 79.3 bits (194), Expect = 4e-14
 Identities = 108/505 (21%), Positives = 224/505 (44%), Gaps = 61/505 (12%)

Query: 650  LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
            L +  E E+E   ++    + E  ++ELA+ E+  +E  E   +L Q + DL     +L+
Sbjct: 843  LLKSAETEKEMANMK---EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL-----QLQ 894

Query: 710  ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENS 769
             +     AEA+ L +  E   R  QL ++ +Q E +     +K    +A   E++E+ N+
Sbjct: 895  VQ-----AEADSLADAEE---RCDQLIKTKIQLEAK-----IKEVTERA---EDEEEINA 938

Query: 770  ELHAKLKHLQDDNNLLKQQLKDFQNHL------NHVVDGLVR--PEEVAARVDELRRKLK 821
            EL AK + L+D+ + LK+ + D +  L       H  +  V+   EE+A   + + +  K
Sbjct: 939  ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 998

Query: 822  LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMALQQEKLA 880
                    H       ++L DLQ +  ++   +K + + E QV +     E +L+QEK  
Sbjct: 999  EKKALQEAHQ------QTLDDLQAEEDKVNTLTKAKIKLEQQVDDL----EGSLEQEK-- 1046

Query: 881  TGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME-EIQGLTD----- 934
                + R   ERA + ++  D +  +     +EN+   L E LK  E E+ GL       
Sbjct: 1047 ----KIRMDLERA-KRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101

Query: 935  ----LQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA 990
                +QLQ+  +E +  + +L E  + ++   AK+++Q   L +EL+++ + +  +    
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161

Query: 991  TAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLL 1050
            +A++ + K +          + +   +    A    +K A +  +L      ++ ++  L
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1221

Query: 1051 RQKGEQFRLEMEKTGVGTGANSQVL-EIEKLNETMERQRTEIARLQNVLDLTGSDNKGGF 1109
             ++  + ++E++         S+    +EK+   +E Q +EI   +       +D     
Sbjct: 1222 EKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQR 1281

Query: 1110 ENVLEEIAELRREVSYQNDYISSMA 1134
              +  E  E  R++  ++  +S ++
Sbjct: 1282 ARLQTESGEYSRQLDEKDTLVSQLS 1306



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 105/538 (19%), Positives = 228/538 (42%), Gaps = 92/538 (17%)

Query: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
            K A+T++ +A  +E  +  +  L K E   ++L++++  L ++K    ND+     QLQ 
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEK----NDL-----QLQV 895

Query: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
            + EA     + LA+ ++                D L+  + +L+  I E   R ED ++ 
Sbjct: 896  QAEA-----DSLADAEERC--------------DQLIKTKIQLEAKIKEVTERAEDEEEI 936

Query: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
                  + + L++E  E K  +   E+   +++KE+ + E+K+               K 
Sbjct: 937  NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---------------KN 981

Query: 1982 LTDQKSKLDQVLSKVL----AAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
            LT++ + LD+ ++K+     A +E  +   ++ +  E    TL++ K +L   EQQ+ + 
Sbjct: 982  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKL---EQQVDDL 1038

Query: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097
             G L    ++   +R D    + +   + K A++    ++      + QL++ L +++ E
Sbjct: 1039 EGSL----EQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN----DKQQLDEKLKKKEFE 1090

Query: 2098 NSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAM 2157
             S +Q ++       +D      +L K++ ++Q    EL++           ++E   A 
Sbjct: 1091 MSGLQSKI-------EDEQALGMQLQKKIKELQARIEELEE-----------EIEAERAS 1132

Query: 2158 RTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKEN-----LPFTMN 2212
            R    + + ++   L+ +++ L E      A +E N+  E E + ++ +     L     
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192

Query: 2213 EGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQL------RHCMSKQAEVLIKG 2266
                 +K   S   + ++    + +++KL   +  +K ++         +SK    L K 
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKM 1252

Query: 2267 KRQTEGTLHSLRRQVDALGELVTSTSADSA-----SSPSLSQLESSLTEDSQLGQNQE 2319
             R  E  L  ++ + +    L+   +A  A     S     QL+   T  SQL + ++
Sbjct: 1253 CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 54/256 (21%), Positives = 117/256 (45%), Gaps = 28/256 (10%)

Query: 237  LQFTIFHLRS-LESLE-GQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETE--ELKSK 292
            LQ  I  LR+ LE  E  + +  Q+  +A ER  L   +       KK +ET+  +++ +
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744

Query: 293  QTRFLEEIKN-QDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL--LKQKTIELTRACQKQ 349
                ++E +N ++K  K++ + AM+     EELK + +T   L  +K+   +  +  Q +
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMM----AEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800

Query: 350  YELEQELAFYKIDAKFEPLNYYPSEY---AEIDKAPDESPYIGKSRYKRNM----FATES 402
             +  ++LA      + + L     E     E ++  +     G  +++R +    + TE 
Sbjct: 1801 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEE 1860

Query: 403  Y---------IIDSAQA-VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTR 452
                      ++D  QA V+  K + +E     ++NL     +  +LE+ E++   A+++
Sbjct: 1861 DRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920

Query: 453  LSELHDEIEKAEQQIL 468
            +++L  +  +   +I+
Sbjct: 1921 VNKLRVKSREVHTKII 1936


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  164 bits (414), Expect = 1e-39
 Identities = 232/1062 (21%), Positives = 467/1062 (43%), Gaps = 131/1062 (12%)

Query: 1321 LENEVSRLEDIMQHLK-------SKKREERWMRASKRQSEKEMEELHHNIDDLLQ-EKKS 1372
            LE+EVSR ++ +  ++         K + + +  +K   E ++E      D L + EK++
Sbjct: 325  LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384

Query: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMT-ELEIEKSLKHHEDIVDEIECIEKTLLKR 1431
            L+ + + LH    +R   +  I+  +E  MT E+  ++S+     +  E+E I +T    
Sbjct: 385  LQLKAK-LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT---- 439

Query: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
             SEL EA +     E       E T + + K     +SL +T  +        +  A  +
Sbjct: 440  -SELSEAPQKSLGHE-----VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493

Query: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
            +K +++ + L            K+ EIL+  N+IV  K S   C +  K+ + E+ Q L+
Sbjct: 494  LKMEKENQRLS-----------KKVEILE--NEIVQEKQSLQNCQNLSKDLMKEKAQ-LE 539

Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ------QQEMAVLDRQLGH 1605
            K IE    N +  +++L++    L    + L + +SQ++++      ++E  +L   +  
Sbjct: 540  KTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAEARVKDIEKENKILHESIKE 598

Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGET--EVTEKCNHIREVKSLLEELSFQKGELNVQI 1663
               +L  ++    Q K +L+     GE   E+  + +H+ +   LL     QK   N++I
Sbjct: 599  TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL-----QKKITNLKI 653

Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHD 1720
            +  K +       +E+E   L+   R++ K     KN+   L+ L+ EN +L    L+  
Sbjct: 654  TCEKIEA------LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707

Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            + V  L+   + + + +LE + L+   +Q K  +E  K   ++ +R           L+ 
Sbjct: 708  RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER-----------LEV 756

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK------- 1833
              + L  E + LQ+  +   KK+ Q +  L   E  ++  Q NLE+L+++ ++       
Sbjct: 757  SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 1834 ---LQQELDQLNRDKLSLHNDISAMQQQ-------LQEKREAVNSLQEELANVQDHLNLA 1883
               L+QE  QL +DK  L  +   ++QQ       L+E    + +L++E   +   + + 
Sbjct: 817  NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876

Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQ---QLQVLQNEIEE-- 1938
            K+  +   + +        R   DI       ED   E+   QQ    L+ L +E+E+  
Sbjct: 877  KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936

Query: 1939 -NKLKLVQQEMMFQRLQKERESE-ESKLETSKVTLKEQQHQLE---KELTDQKSKLDQVL 1993
             NK +L+  E       K  ES+ ES L+ S    +E+   LE   +E T+   +L Q L
Sbjct: 937  LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996

Query: 1994 SKVLAAEERVRTLQEEERWCES---LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADS 2050
              V    E ++  Q+EER  +S   +    ++ +R+  E  ++L++    L+ +++   +
Sbjct: 997  KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056

Query: 2051 MRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIEL 2110
            ++A+   L+ Q         KQ+ +    L+ Q   L++  +  +++N+ +Q + A +++
Sbjct: 1057 LQAEKQALKTQL--------KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108

Query: 2111 VAQDNHERARRLMKELNQMQYEYTELKKQ----MANQKDL---------ERRQMEISDAM 2157
                 + ++  LM +  Q+  + + L+ +    +  ++DL         +  ++E+    
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168

Query: 2158 RTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFE 2217
            +  + E       +LK+ ++ L     DLE    +    +G+LE L++ L     +   E
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228

Query: 2218 EKLNFSQVHIMDEHWRGEALREKLRHREDRL--KAQLRHCMSKQAEVLIKGKR----QTE 2271
             K N   V    +   GE   ++L H   +L  + ++     K  + L+   +    + E
Sbjct: 1229 NK-NHETVAAEYKKLCGE--NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285

Query: 2272 GTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQ 2313
                 L+ Q   L   +TST  ++     LSQL+ +L E+++
Sbjct: 1286 AEFSKLKEQYQQLD--ITSTKLNN-QCELLSQLKGNLEEENR 1324



 Score =  147 bits (372), Expect = 9e-35
 Identities = 198/941 (21%), Positives = 419/941 (44%), Gaps = 108/941 (11%)

Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
            +KR    +     LA+A++++   +++ +   E+  D K+ L Q E +     +R Q+  
Sbjct: 240  MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL----KRLQQEN 295

Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
            +NL+   +  R  + +   L +  ++ +++  E+++    +  D +    + E+L E+ Q
Sbjct: 296  MNLLSDARSARMYRDELDALREKAVRVDKLESEVSR-YKERLHDIEFYKARVEELKEDNQ 354

Query: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
             L +   M E           E       K  ELEK   Q+ ++  +M  ++R +  KK 
Sbjct: 355  VLLETKTMLEDQ--------LEGTRARSDKLHELEKENLQLKAKLHDME-MERDMDRKKI 405

Query: 1609 ELHLLQGSM---VQAKADLQEALRLG-ETEVTEKCNHIREVKSLLEELSFQKGELNVQIS 1664
            E  L++ +M   +  K  + E+L LG E E   + + + E     + L  +  EL     
Sbjct: 406  E-ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ--KSLGHEVNEL----- 457

Query: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
               T   L+K E+E +          ++K   EL+  +D ++    ++  ++ ++ +   
Sbjct: 458  ---TSSRLLKLEMENQ---------SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505

Query: 1725 ELEKTQVAVLEEKLELENLQQISQ---QQKGEIEWQ-KQLLERDKREIERMTAESRALQS 1780
            ++E  +  +++EK  L+N Q +S+   ++K ++E   + L E  +R+I+ +  E+  L  
Sbjct: 506  KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             V  L   ++  Q   +   K + +  ++L    E+ K   S L K+E   R++++EL+ 
Sbjct: 566  TVSSL---RQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEH 619

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
              ++K     ++      L+++ E    LQ+++ N    L +  + +    +    L  E
Sbjct: 620  Y-KEKGERAEELENELHHLEKENEL---LQKKITN----LKITCEKIEALEQENSELERE 671

Query: 1901 QTRLQKDISEWAN---RFEDCQKEEETKQQQLQVLQNEIEENK---LKLVQQEMMFQRLQ 1954
              +L+K +  + N   + E  +KE     ++   L+  +E  K   +K+ Q ++  + L+
Sbjct: 672  NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731

Query: 1955 KERESEESKLETSKVTLKE-------------QQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
             E+E  +  LE  K + K+             +  +L+K L +   K+ Q+ S++   E 
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 2002 RVRTLQE-------EERWCESLE---KTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
              +TLQ+         +  E LE   K+L Q   QL + ++QL +++  L    +  D+ 
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851

Query: 2052 RADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELV 2111
              + ++       E K   K++   KE+  ++  +LEK   E  +  +   K + T+   
Sbjct: 852  LEENNVKIGNLEKENKTLSKEIGIYKESC-VRLKELEKENKELVKRATIDIKTLVTLRED 910

Query: 2112 AQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTS 2171
                  + +++  +L ++ +   EL+K   N++ L   +    D  + L+S+++  ++ S
Sbjct: 911  LVSEKLKTQQMNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967

Query: 2172 LKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM--D 2229
            L+   + +  L A LE     N+ L  EL+++K+N    + +   EE++  S   I   D
Sbjct: 968  LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGED 1026

Query: 2230 EHWRGEA---LREKLRHRE-----DRLKAQL---RHCMSKQAEVLIKGKRQTEGTLHSLR 2278
              W  E+    RE L+ ++     +R  A L   +  +  Q + L       +  + +L+
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086

Query: 2279 RQVDALGELVTSTSADSA-----SSPSLSQLESSLTEDSQL 2314
            RQ  +L E  T+    +A     +S   SQ  S + +++QL
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127



 Score =  123 bits (309), Expect = 2e-27
 Identities = 186/873 (21%), Positives = 379/873 (43%), Gaps = 101/873 (11%)

Query: 1318 HHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
            H +++   S+L  I    +  K+E   +   K + E+  EEL + +  L +E + L+ ++
Sbjct: 593  HESIKETSSKLSKIEFEKRQIKKE---LEHYKEKGERA-EELENELHHLEKENELLQKKI 648

Query: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELRE 1437
              L  T +K +  +     N E      +++K+L   +++  ++E +E    K  S+L E
Sbjct: 649  TNLKITCEKIEALE---QENSELERENRKLKKTLDSFKNLTFQLESLE----KENSQLDE 701

Query: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD-Q 1496
             +  L      L C               K + LQ E+   E E+   +  + L+KA  +
Sbjct: 702  ENLELRRNVESLKC------------ASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749

Query: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            +   L+   + L+    + ++ L+  NK +   +S+ Q L  + + L + L++L      
Sbjct: 750  KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL------ 803

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
              +     L+ L++    L+ + ++LEK K Q+  + + +           EE ++  G+
Sbjct: 804  --KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861

Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
            + +    L + + +      E C  ++E++   +EL  ++  +++     KT +TL +++
Sbjct: 862  LEKENKTLSKEIGI----YKESCVRLKELEKENKEL-VKRATIDI-----KTLVTL-RED 910

Query: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736
            +  E+   Q    QM+    +L + L+ + L    L   +   D R   LE    + L++
Sbjct: 911  LVSEKLKTQ----QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK 966

Query: 1737 KLEL--ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794
             LE+  E +  +  + +    + +QL  R + +  +   E+   +   E + +    +  
Sbjct: 967  SLEIKEEKIAALEARLEESTNYNQQL--RQELKTVKKNYEALKQRQDEERMVQSSPPISG 1024

Query: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISA 1854
            + + WE++  +T R L   ++     + N   L+   + L+ +L QL     +L   I A
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084

Query: 1855 MQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
            +Q+Q    +E   +LQ + A +Q   +               LL +Q+ L+       N 
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE-------NE 1137

Query: 1915 FEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 1974
             E   KE E     L+ L + + ++  KL   E++ +R   E ES  SK      TLK  
Sbjct: 1138 NESVIKERE----DLKSLYDSLIKDHEKL---ELLHERQASEYESLISK----HGTLKSA 1186

Query: 1975 QHQLEKELTDQKSKLDQVLSKVLAAE--ERVRTLQEEERWCESL-EKTLSQTKRQLSERE 2031
               LE E  D + + +Q+L +    E  E++  +++E+   E+   +T++   ++L    
Sbjct: 1187 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246

Query: 2032 QQLVEKSGELLALQKEADSMRADF----SLLRNQFLTERKKAEKQVASLKEALKIQRSQL 2087
             +L     +LL   KE + ++ D     SLL N  L E+ + E + + LKE    Q  QL
Sbjct: 1247 DRLNHTYSQLL---KETEVLQTDHKNLKSLLNNSKL-EQTRLEAEFSKLKE----QYQQL 1298

Query: 2088 EKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQMQYEYTELKKQMANQK 2144
            +  +   K  N C        EL++Q   +  E  R L+ ++  +  +   L +Q    K
Sbjct: 1299 D--ITSTKLNNQC--------ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348

Query: 2145 DL----ERRQMEISDAMRTLKSEVKDEIRTSLK 2173
            DL    +R+ ++  + +R  K +++++I    K
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381



 Score =  115 bits (288), Expect = 5e-25
 Identities = 182/897 (20%), Positives = 369/897 (41%), Gaps = 150/897 (16%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            E H+LE E   L+  + +LK    +   +     + E+E  +L   +D      K+L  +
Sbjct: 633  ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF----KNLTFQ 688

Query: 1377 VEELHRTVQKRQQQKDFIDGNVESL------MTELEIEKSLKHHEDIVDEIECIEKTLLK 1430
            +E L +   +  ++   +  NVESL      M +L++E     ++++  E E ++K L  
Sbjct: 689  LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE-----NKELESEKEQLKKGLEL 743

Query: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490
             ++  ++ +RL    +  L    ++ +  +E   ++ + + Q ES+ ++LE   Q    N
Sbjct: 744  LKASFKKTERLEVSYQG-LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKN 799

Query: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
                   L  L+  +K LEQ                         L K+ + L +E  +L
Sbjct: 800  -------LEELKISSKRLEQ-------------------------LEKENKSLEQETSQL 827

Query: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
            +KD +  E+      Q  +  +  L+    ++  L+ +  +  +E+ +        KE  
Sbjct: 828  EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887

Query: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKC------NHIREVKSLLEELSFQKGEL----- 1659
               +  + +A  D++  + L E  V+EK       N + ++   LE++   K  L     
Sbjct: 888  KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947

Query: 1660 ----NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
                  ++ E K + TL K+ +E +EE +  +  ++ +     + +   L+      + L
Sbjct: 948  STDDRYKLLESKLESTL-KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006

Query: 1716 KLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAES 1775
            K + D+         ++  + K E E     SQ+   E+   K  L   +R    + AE 
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERE-----SQETTRELLKVKDRLIEVERNNATLQAEK 1061

Query: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQ 1835
            +AL++ ++ L  +  +LQ +       LA  ++ ++  E+N+ ++  N         KLQ
Sbjct: 1062 QALKTQLKQLETQNNNLQAQI------LALQRQTVSLQEQNTTLQTQN--------AKLQ 1107

Query: 1836 QELDQLNRDKLSLHN---DISAMQQQLQEKREAVNSLQEELANVQDHL--NLAKQDLLH- 1889
             E   LN    SL N    +   Q  L+ + E+V   +E+L ++ D L  +  K +LLH 
Sbjct: 1108 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHE 1167

Query: 1890 -TTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM 1948
                  + L+S+   L                  ++  + L+V   ++E+   +L++Q+ 
Sbjct: 1168 RQASEYESLISKHGTL------------------KSAHKNLEVEHRDLEDRYNQLLKQKG 1209

Query: 1949 MFQRLQKERESEESKLETSKVTLKEQQHQL----EKELTDQKSKLDQVLSKVLAAEERVR 2004
              + L+K       K+E  K+ L+ + H+      K+L  +  +L+   S++L   E   
Sbjct: 1210 QLEDLEK-----MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--- 1261

Query: 2005 TLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLT 2064
             LQ + +  +SL       + +L     +L E+  +L     + ++     S L+     
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321

Query: 2065 ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMK 2124
            E +    Q+    + L +Q     + LLEQ  E+  +              H   R+ + 
Sbjct: 1322 ENRHLLDQI----QTLMLQ----NRTLLEQNMESKDL-------------FHVEQRQYID 1360

Query: 2125 ELNQMQYEYTELKKQMANQKDL------ERRQMEISDAMRTLKSEVKDEIRTSLKNL 2175
            +LN+++ +  +L++++ +Q          RR   I+  MR L    KD  R   K+L
Sbjct: 1361 KLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL 1417



 Score =  107 bits (266), Expect = 2e-22
 Identities = 143/684 (20%), Positives = 302/684 (44%), Gaps = 104/684 (15%)

Query: 445  KISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL-- 502
            +++ A+ ++  L  E+E+  +Q+L   +E +Q+E  I+LK++ +   +LL    S R+  
Sbjct: 252  ELADAKAKIRRLRQELEEKTEQLLDCKQELEQME--IELKRLQQENMNLLSDARSARMYR 309

Query: 503  QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
              ++ LR++A    ++++K + E++  ++ + D++     ++     +  +   K+  E 
Sbjct: 310  DELDALREKA----VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365

Query: 563  QLD----------IMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK 612
            QL+           + K+  QL+++L ++      + ++I++L E+    ++A  +++ +
Sbjct: 366  QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425

Query: 613  DL------------EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
             L              +    Q+ LG    + T ++    KL  E ++L + + E+    
Sbjct: 426  SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR--LLKLEMENQSLTKTVEELRTTV 483

Query: 661  DQLE-----IVAMDAENMR--KELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLN 713
            D +E     I+ M+ EN R  K++  LE+ + ++ +   + Q    DL   +A+LE  + 
Sbjct: 484  DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI- 542

Query: 714  LRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHA 773
                    L+E  E+  ++ + E   L   +   RQ  ++ +      ++ E+EN  LH 
Sbjct: 543  ------ETLRENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHE 594

Query: 774  KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPS 833
             +K      + ++ + +  +  L H        +E   R +EL  +L       ++   +
Sbjct: 595  SIKETSSKLSKIEFEKRQIKKELEHY-------KEKGERAEELENELH------HLEKEN 641

Query: 834  DVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQ------EEMALQQEKLATGQEEFR 887
            ++L K + +L+    +I A  + E  E +   RKL+      + +  Q E L   ++E  
Sbjct: 642  ELLQKKITNLKITCEKIEALEQ-ENSELERENRKLKKTLDSFKNLTFQLESL---EKENS 697

Query: 888  QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
            Q  E  LE R N                     E+LK          L+ +E + EKE++
Sbjct: 698  QLDEENLELRRNV--------------------ESLKCASMKMAQLQLENKELESEKEQL 737

Query: 948  LAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
               L  L+   KK E  +   Q  GLD E ++L+K +  S+K    +L      L+  + 
Sbjct: 738  KKGLELLKASFKKTERLEVSYQ--GLDIENQRLQKTLENSNK-KIQQLESELQDLEMENQ 794

Query: 1007 TVMKINQE---RAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK 1063
            T+ K  +E    ++ L++ E+ ++   Q    L + + ++E     LRQ+ E     +E+
Sbjct: 795  TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854

Query: 1064 TGVGTGANSQVLEIEKLNETMERQ 1087
              V  G       +EK N+T+ ++
Sbjct: 855  NNVKIG------NLEKENKTLSKE 872



 Score =  105 bits (263), Expect = 4e-22
 Identities = 206/965 (21%), Positives = 409/965 (42%), Gaps = 161/965 (16%)

Query: 260  RQEAFERFSLE------EVERLERDLEKKM--------------IETEELKSKQTRFLEE 299
            R E+ +  S+E      ++ RL ++LE+K               IE + L+ +    L +
Sbjct: 242  RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 300  IKN----QDKLNKSLKEEAM--------------------LQKQSCEELKSD----LNTK 331
             ++    +D+L+ +L+E+A+                      K   EELK D    L TK
Sbjct: 302  ARSARMYRDELD-ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360

Query: 332  NELLKQKTIELTRA-CQKQYELEQELAFYKI---------DAKFEPLNYYPSEYAEIDKA 381
              L  Q  +E TRA   K +ELE+E    K          D   + +     E   ++ A
Sbjct: 361  TMLEDQ--LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418

Query: 382  P----DESPYIG--KSRYKRNMFATES------YIIDSAQAVQIKKMEPD--------EQ 421
                 DES ++G    +  R    +E+      + ++   + ++ K+E +        E+
Sbjct: 419  QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478

Query: 422  LRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL-EEA 480
            LR    ++ G+     ++E + +++S    ++  L +EI + +Q +       K L +E 
Sbjct: 479  LRTTVDSVEGNASKILKMEKENQRLS---KKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535

Query: 481  IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ--- 537
             QL+K  E  ++   +Q+      + +   E L+  +   +Q+ +I+ + + +KD++   
Sbjct: 536  AQLEKTIETLRENSERQIK-----ILEQENEHLNQTVSSLRQRSQISAEAR-VKDIEKEN 589

Query: 538  -IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE--EIKD 594
             I  +S+     K S ++ +K   +++L+   ++ ++ E  L+  L  + KE E  + K 
Sbjct: 590  KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKI 648

Query: 595  LEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT 654
               ++T  +I A E    +LE     L++ L + K    Q ++    L  E   L +   
Sbjct: 649  TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENL 704

Query: 655  EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNL 714
            E+ +  + L+  +M    ++ E  ELES   E+ ++   L+  +      E  LE     
Sbjct: 705  ELRRNVESLKCASMKMAQLQLENKELES---EKEQLKKGLELLKASFKKTE-RLEVSYQG 760

Query: 715  RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK---------- 764
             D E  +L++ LE   +  Q  +S LQ +LE E Q L+  L + + S ++          
Sbjct: 761  LDIENQRLQKTLENSNKKIQQLESELQ-DLEMENQTLQKNLEELKISSKRLEQLEKENKS 819

Query: 765  -EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLG 823
             EQE S+L    K L+ +N  L+QQ +     L          EE   ++  L ++ K  
Sbjct: 820  LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL----------EENNVKIGNLEKENKTL 869

Query: 824  TGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMALQQ-----E 877
            + E+ I+  S V    L +L+K+  E++ R+  + +    +RE  + E++  QQ     E
Sbjct: 870  SKEIGIYKESCV---RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926

Query: 878  KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIH-YLQENLKSMEEIQGLTDLQ 936
            KL    E+     ER L      D++  + R + +E+++   L+++L+  EE     + +
Sbjct: 927  KLTHELEKIGLNKERLLH-----DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEAR 981

Query: 937  LQEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELT 995
            L+E+    +++  +L+ ++K  + L+  + +E++      +           +  T EL 
Sbjct: 982  LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041

Query: 996  IAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGE 1055
              KD+L       +++ +  A    E +    +  Q        +A+I  LQ       E
Sbjct: 1042 KVKDRL-------IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1094

Query: 1056 QFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEE 1115
            Q           T   +Q  +++  N T+  Q T +      L +  S  +   E+V++E
Sbjct: 1095 Q----------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144

Query: 1116 IAELR 1120
              +L+
Sbjct: 1145 REDLK 1149



 Score =  103 bits (256), Expect = 3e-21
 Identities = 189/832 (22%), Positives = 349/832 (41%), Gaps = 122/832 (14%)

Query: 265  ERFSLEEVERLERDLEK------KMIET-EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
            E+ SL+  + L +DL K      K IET  E   +Q + LE+    + LN+++       
Sbjct: 517  EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ--ENEHLNQTVSSLRQRS 574

Query: 318  KQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE 377
            + S E    D+  +N++L +   E +    K       + F K   K E L +Y  +   
Sbjct: 575  QISAEARVKDIEKENKILHESIKETSSKLSK-------IEFEKRQIKKE-LEHYKEKGER 626

Query: 378  IDKAPDESPYIGKSRYKRNMFATESYII-DSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
             ++  +E  ++ K         T   I  +  +A++ +  E + + R     L     L 
Sbjct: 627  AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686

Query: 437  TQLEDKEKKISAAQTRLSELHDEIEK---AEQQILRATEEFKQLE-EAIQLKK------- 485
             QLE  EK+ S       EL   +E    A  ++ +   E K+LE E  QLKK       
Sbjct: 687  FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746

Query: 486  ---------ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL 536
                     +S  G D+  ++L   L+  NK  Q+   LE +++  + E    QK +++L
Sbjct: 747  SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ---LESELQDLEMENQTLQKNLEEL 803

Query: 537  QIAIDSLDSKDPKHSHMKAQKSGKEQ---QLDIMNKQYQQ----LESRLDEILSRIAKET 589
            +I+   L+  + ++  ++ + S  E+   QL+  NK+ +Q     ++ L+E   +I    
Sbjct: 804  KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863

Query: 590  EEIKDLEEQL---TEGQIAANEALKKDLEGV---------ISGLQEYLGTIKGQATQAQN 637
            +E K L +++    E  +   E  K++ E V         +  L+E L + K +  Q  N
Sbjct: 864  KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923

Query: 638  ECRKLRDEKETL---LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
            +  KL  E E +    +RL   EQ  D         +  +   ++LES L++      SL
Sbjct: 924  DLEKLTHELEKIGLNKERLLHDEQSTD---------DRYKLLESKLESTLKK------SL 968

Query: 695  QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER--QALK 752
            +  +  ++A EA LE   N       QL++EL+ V +       AL+   ++ER  Q+  
Sbjct: 969  EIKEEKIAALEARLEESTNYN----QQLRQELKTVKK----NYEALKQRQDEERMVQSSP 1020

Query: 753  NALGKAQFSEEKEQENSELHAKLKH-----------LQDDNNLLKQQLKDFQNHLNHVVD 801
               G+    E + QE +    K+K            LQ +   LK QLK  +   N++  
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080

Query: 802  GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR--SKWERD 859
             ++  +     + E    L+    ++ +   +  L      L  Q +++L +  S    +
Sbjct: 1081 QILALQRQTVSLQEQNTTLQTQNAKLQVE--NSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138

Query: 860  EAQVRERK----LQEEMALQQEKLATGQEEFRQACE-RALEARMNFDKRQH---EARIQQ 911
            E+ ++ER+    L + +    EKL    E  RQA E  +L ++    K  H   E   + 
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHE--RQASEYESLISKHGTLKSAHKNLEVEHRD 1196

Query: 912  MENEIHYLQENLKSMEEIQGLTDLQLQE---ADEEKERILAQLREL-EKKKKLEDAKSQ- 966
            +E+  + L +    +E+++ +  ++ ++    ++  E + A+ ++L  +  +L    SQ 
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256

Query: 967  ---EQVFGLD-KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE 1014
                +V   D K LK L            AE +  K+Q + L  T  K+N +
Sbjct: 1257 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1308



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 146/678 (21%), Positives = 292/678 (43%), Gaps = 95/678 (14%)

Query: 505  VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL 564
            V KL    L   +Q +K+++ I    + I+ L       D+K    +H++     +E   
Sbjct: 121  VKKLLLLLLGCAVQCQKKEEFI----ERIQGLDF-----DTKAAVAAHIQEVTHNQENVF 171

Query: 565  DIMNKQYQQLESR-LDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKD----LEGVIS 619
            D+   +   +    ++ +L  +A   + + D  ++ +E  I  +E  ++D    L    S
Sbjct: 172  DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE--ERDGLHFLPHASS 229

Query: 620  GLQEYLGT-----------IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI--V 666
              Q   G+           +  +   A+ + R+LR E E   ++L + +QE +Q+EI   
Sbjct: 230  SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289

Query: 667  AMDAENMRKELAELESALQEQHEVNA------SLQQTQGDLSAYEAELEARLNLRDAEAN 720
             +  ENM   L++  SA   + E++A       + + + ++S Y+  L   +    A   
Sbjct: 290  RLQQENMNL-LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH-DIEFYKARVE 347

Query: 721  QLKEE----LEKVTRL-TQLEQSALQA----ELEKERQALKNALGKAQFSEEKEQENSEL 771
            +LKE+    LE  T L  QLE +  ++    ELEKE   LK  L       + E E    
Sbjct: 348  ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL------HDMEMERDMD 401

Query: 772  HAKLKHLQDDN---NLLKQQLKDFQNHLNHVVDGLVRPEEVAA--------RVDEL--RR 818
              K++ L ++N    + ++Q  D   HL   ++ + R  E++          V+EL   R
Sbjct: 402  RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461

Query: 819  KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878
             LKL     ++    + L  ++  ++   S+IL   K E      +   L+ E+  +++ 
Sbjct: 462  LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQS 520

Query: 879  LATGQEEFRQACER--ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT-DL 935
            L   Q   +   +    LE  +   +   E +I+ +E E  +L + + S+ +   ++ + 
Sbjct: 521  LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580

Query: 936  QLQEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAEL 994
            ++++ ++E + +   ++E   K  K+E  K Q     + KEL+  K+    +++L     
Sbjct: 581  RVKDIEKENKILHESIKETSSKLSKIEFEKRQ-----IKKELEHYKEKGERAEELENELH 635

Query: 995  TIAKD-QLKSLHGTVMKINQERAEELQ----EAERFSRKAAQAARDLTRAEAEIELLQNL 1049
             + K+ +L     T +KI  E+ E L+    E ER +RK  +          ++E L+  
Sbjct: 636  HLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE 695

Query: 1050 LRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGG 1108
              Q  E+  LE+ +       A+ ++ +++  N+ +E ++ ++ +   +L       K  
Sbjct: 696  NSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL-------KAS 747

Query: 1109 FENVLEEIAELRREVSYQ 1126
            F+         R EVSYQ
Sbjct: 748  FKKT------ERLEVSYQ 759



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 157/777 (20%), Positives = 316/777 (40%), Gaps = 153/777 (19%)

Query: 53   CEQVEIADENNMLLDYQDHK---GADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSK 109
            CE++E  ++ N  L+ ++ K     DS   + +  E+L K+ ++ D        NL L +
Sbjct: 655  CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE------NLELRR 708

Query: 110  DGGKKFKYIENLEKCVKLEVLNLSYN---LIGKIEKLDKLLKLRELNLSYNKISKIEGIE 166
            +       +E+L KC  +++  L      L  + E+L K L+L  L  S+ K  ++E   
Sbjct: 709  N-------VESL-KCASMKMAQLQLENKELESEKEQLKKGLEL--LKASFKKTERLE--- 755

Query: 167  NMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILV 226
               + Q L++    ++       KK++ L          S LQD+              +
Sbjct: 756  --VSYQGLDIENQRLQKTLENSNKKIQQLE---------SELQDLE-------------M 791

Query: 227  ENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
            EN   TL   L+      + LE LE +  + +           +E  +LE+D  KK +E 
Sbjct: 792  ENQ--TLQKNLEELKISSKRLEQLEKENKSLE-----------QETSQLEKD--KKQLEK 836

Query: 287  EELKSKQTRFLEE---------IKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQ 337
            E  + +Q   +++         I N +K NK+L +E  + K+SC  LK       EL+K+
Sbjct: 837  ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896

Query: 338  KTIELTRACQKQYELEQELA--------FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
             TI++      + +L  E            K+  + E +          +++ D+   + 
Sbjct: 897  ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956

Query: 390  KSRYKRNMFATESYIIDSAQAVQIKKMEP---DEQLRNDHMNLRGHTPLDTQLEDKEKKI 446
            +S+ +  +  +     +   A++ +  E    ++QLR +   ++ +     Q +D+E+ +
Sbjct: 957  ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016

Query: 447  SAAQTRLSELHDEIEKAEQQILRATEEFK-QLEEAIQLKKISEAGKDLLYKQLSGRLQLV 505
             ++   +S   ++ E+  Q+  R   + K +L E  +     +A K  L  QL       
Sbjct: 1017 QSSPP-ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075

Query: 506  NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP----KHSHMKAQKSGKE 561
            N L+ + L L+ Q    +++    Q +   LQ+   +L+S+      +++ +  Q+S  E
Sbjct: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135

Query: 562  QQLDIMNKQYQQLESRLDEILS----------RIAKETEEI-----------KDLEEQLT 600
             + + + K+ + L+S  D ++           R A E E +           K+LE +  
Sbjct: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195

Query: 601  EGQIAANEALKK-----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL------ 649
            + +   N+ LK+     DLE ++   QE +            E +KL  E + L      
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255

Query: 650  LQRLTEV-----------------------------EQERDQLEIVAMDAENMRKELAEL 680
            L + TEV                             +++  QL+I +    N  + L++L
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315

Query: 681  ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
            +  L+E++     L Q Q  +      LE  +  +D    + ++ ++K+  L + ++
Sbjct: 1316 KGNLEEEN--RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  162 bits (409), Expect = 5e-39
 Identities = 221/1014 (21%), Positives = 453/1014 (44%), Gaps = 127/1014 (12%)

Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNI----DDLLQEKKSLECEVEELHRT 1383
            L++  QH++    E    RA   ++   + E+   +    D   Q    LE ++++L   
Sbjct: 357  LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416

Query: 1384 VQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLA 1443
            V+   ++K         L+ +LE EK          E E I K  L+ +++L  A   + 
Sbjct: 417  VEAADREK-------VELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR--IK 467

Query: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER----RAQETAVNLVK------ 1493
            E E  L   K K      +  D + + +  +S   ELE+    R QE A    +      
Sbjct: 468  ELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKP 527

Query: 1494 ---ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
                D  L  LQ  +   E+ ++ + +  +EI  +     +  +   K+ + L    +KL
Sbjct: 528  AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKL 587

Query: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL----DRQLGHK 1606
             K+ E  +   +H  +  + S+V+   K     KL++ + S QQ M  L     + LG +
Sbjct: 588  SKENESLKSKLEHANK--ENSDVIALWK----SKLETAIASHQQAMEELKVSFSKGLGTE 641

Query: 1607 KEELHLLQGSMVQAKADLQEALR-LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISE 1665
              E   L+  + + + D Q  +  L   + +E+  H +E+++L       + +L   I E
Sbjct: 642  TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL-------RAKLMKVIKE 694

Query: 1666 RKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQ---LENHELQGLKLQHDQR 1722
            ++  L  I+ +++K E+          +H  E+++ L+ LQ   ++  EL+ L+ + +++
Sbjct: 695  KENSLEAIRSKLDKAED----------QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 744

Query: 1723 VSELEK--TQVAVLEEKL-ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
               ++   +Q+   EEKL +L+ L++ S + K E++  +Q LE  +++I+ +  E  A  
Sbjct: 745  TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804

Query: 1780 SCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD 1839
            S    +++E +  + K    ++ L++  +V               E LE  ++ L+++  
Sbjct: 805  SKASSITRELQGRELKLTNLQENLSEVSQVK--------------ETLEKELQILKEKFA 850

Query: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
            + + + +S+   +     +L +K E  N L  +L  ++++L   +       + ++ L+ 
Sbjct: 851  EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 910

Query: 1900 EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE- 1958
             + +L+ DI+E      D   +      +L++ + ++EE +LKL +       LQK  E 
Sbjct: 911  AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970

Query: 1959 ----SEESKLETSKVTLKEQQHQLEKELTDQKSKLD---QVLSKVLAAEERV--RTLQEE 2009
                +E+S+ E +K   +E++ +LE++L+D + K++       ++ A  ER    T  + 
Sbjct: 971  MTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 1029

Query: 2010 ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKA 2069
            E   ++L+KTL  T+ +L    ++      EL  L+K+AD  +A              + 
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA-------------AQT 1076

Query: 2070 EKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE---LVAQDNHERARRLMKEL 2126
             +    + E +  ++++   +L + KQ N+ +Q E+ T++   L   +   +++ L+   
Sbjct: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136

Query: 2127 NQMQYEY---TELKKQMANQKD-----LERRQMEISDAMRTLKSEV----KDEIRTSLKN 2174
            NQ   E+    E  KQ A QK      L+   +++++ +   + EV    K E   S+ N
Sbjct: 1137 NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLN 1196

Query: 2175 LNQFLPELPADLEAILERNENLEGELESLKENLPFT---MNEGPFE-EKLNFSQVHIMDE 2230
             NQ L     + + I + +E    E  SL++++  T   + E   E EKL      +  E
Sbjct: 1197 -NQLLEMKKRESKFIKDADE----EKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE 1251

Query: 2231 HWRGEALREKLRHRE-DRLKAQLRHCMSKQAEVLIK-GKRQTEGTLHSLRRQVD 2282
            +   ++L   ++  E D++K +L+    K  E+ +K  KRQ   +  +   Q D
Sbjct: 1252 NASAKSLHSVVQTLESDKVKLELK---VKNLELQLKENKRQLSSSSGNTDTQAD 1302



 Score =  112 bits (279), Expect = 6e-24
 Identities = 212/970 (21%), Positives = 397/970 (40%), Gaps = 169/970 (17%)

Query: 196  RVLNLKGNKISSLQDISKL-------KPLQDLISLILVENPVVTLPHYLQFT-IFHLRSL 247
            R++ L+ +    +Q++++L       KP  D+   + +   + +L   L+ T   H R +
Sbjct: 500  RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 559

Query: 248  ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
             SL+       +   A E    +E++ L    EK   E E LKSK     +E  +   L 
Sbjct: 560  TSLK-------EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW 612

Query: 308  KSLKEEAMLQ-KQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE 366
            KS  E A+   +Q+ EELK   +     L  +T E         EL+ ++   ++D + E
Sbjct: 613  KSKLETAIASHQQAMEELKVSFSKG---LGTETAEFA-------ELKTQIEKMRLDYQHE 662

Query: 367  PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDH 426
              N    +                               DS +A   K+ME    LR   
Sbjct: 663  IENLQNQQ-------------------------------DSERAAHAKEMEA---LRAKL 688

Query: 427  MNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKI 486
            M +         +++KE  + A +++L       +KAE Q L   E+         L K+
Sbjct: 689  MKV---------IKEKENSLEAIRSKL-------DKAEDQHLVEMED--------TLNKL 724

Query: 487  SEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK 546
             EA  ++  K+L                L+ +  +Q + I     ++K  +  +  LD+ 
Sbjct: 725  QEA--EIKVKELEV--------------LQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 768

Query: 547  DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA 606
                S  K++     QQL+   KQ + LE   +   S+ +  T E++  E +LT  Q   
Sbjct: 769  RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828

Query: 607  NEA--LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
            +E   +K+ LE  +  L+E       +A   Q      R  +ET+     ++ Q+ +Q  
Sbjct: 829  SEVSQVKETLEKELQILKEKFAEASEEAVSVQ------RSMQETV----NKLHQKEEQFN 878

Query: 665  IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE 724
            +++ D E +R+ LA++E+  +E+ E    L + +  L    AE+        ++  ++ +
Sbjct: 879  MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938

Query: 725  ELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL 784
            EL    RL + +   LQ +L K  +   + L K+      + E S+  A  KH +++   
Sbjct: 939  EL----RLKERDVEELQLKLTKANEN-ASFLQKSIEDMTVKAEQSQQEAAKKH-EEEKKE 992

Query: 785  LKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQ 844
            L+++L D +  +          E    +  EL+ + +  T E           + L +LQ
Sbjct: 993  LERKLSDLEKKM----------ETSHNQCQELKARYERATSETKTKHE-----EILQNLQ 1037

Query: 845  KQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQ--EEFRQACERALEARMNF-- 900
            K   +   + K  R+E     ++L EE+  Q +K    Q  E+  Q  E+  + +     
Sbjct: 1038 KTLLDTEDKLKGAREENSGLLQEL-EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096

Query: 901  ---DKRQHEARIQQMENEIHYLQE-NLKSMEEIQGLTDLQLQEAD--EEKERILAQLREL 954
               D +Q  A++Q   NE+  L+E NLK++EE+    +L   E    EE  + +  L++ 
Sbjct: 1097 SLEDTKQTNAKLQ---NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA 1153

Query: 955  EKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE 1014
              +K  + +  QE+   L +EL + +  V +  KL   E ++  +QL  +     K  ++
Sbjct: 1154 AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL-EEERSVLNNQLLEMKKRESKFIKD 1212

Query: 1015 RAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQV 1074
              EE    +   +  +  +  LT  +AE+E L+N              +  V  G N+  
Sbjct: 1213 ADEEKASLQ---KSISITSALLTEKDAELEKLRN--------------EVTVLRGENASA 1255

Query: 1075 LEIEKLNETMERQRTEIARLQNVLDLTGSDNK----GGFENVLEEIAELRREVSYQNDYI 1130
              +  + +T+E  + ++      L+L   +NK        N   +  E  R    Q D++
Sbjct: 1256 KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFL 1315

Query: 1131 SSMADPFKRR 1140
            +S+    +R+
Sbjct: 1316 NSVIVDLQRK 1325



 Score =  103 bits (258), Expect = 2e-21
 Identities = 181/799 (22%), Positives = 351/799 (43%), Gaps = 132/799 (16%)

Query: 430  RGHTPLDTQLEDKEKKISAAQTRLSE--------------LHDEIEKAEQQIL----RAT 471
            R    L  QLE++++K+   Q R+ E               H  I++ EQ +L    +A 
Sbjct: 422  REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD 481

Query: 472  EEFKQLEEAIQLKKISEAGKDL-LYKQLSGRLQLVNKLRQE------ALDLELQMEKQKQ 524
            +  ++LE+  ++  +SE  + + L K L+ R+Q V +LR+       A D+++ +    Q
Sbjct: 482  KLQRELEDT-RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL-SLLQ 539

Query: 525  EIAGKQKEIK----DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDE 580
            EI+  Q++++    D Q  I SL        H  A++   ++++  +    ++L    + 
Sbjct: 540  EISSLQEKLEVTRTDHQREITSL------KEHFGAREETHQKEIKALYTATEKLSKENES 593

Query: 581  ILSRIA---KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
            + S++    KE  ++  L +   E  IA+++   ++L+   S   + LGT   +  + + 
Sbjct: 594  LKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS---KGLGTETAEFAELKT 650

Query: 638  ECRKLRDEKETLLQRL------------TEVEQERDQLEIVAMDAENMRKELAELESALQ 685
            +  K+R + +  ++ L             E+E  R +L  V  + EN  + +       +
Sbjct: 651  QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 710

Query: 686  EQH--EVNASLQQTQ------GDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
            +QH  E+  +L + Q       +L   +A+   +  + D   +QLK   EK+  L  L +
Sbjct: 711  DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770

Query: 738  SALQ--AELEKERQALKNALGKAQFSE-EKEQENSELHA----------KLKHLQDDNNL 784
            ++ +  +E++K RQ L+ A  + +  E EK  E+S+  +          KL +LQ++ + 
Sbjct: 771  ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830

Query: 785  LKQQLKDFQNHLNHVVDGLVRPEEVAARV----DELRRKLKLGTGEMN-IHSPSDVLGKS 839
            + Q  +  +  L  + +      E A  V     E   KL     + N + S  + L ++
Sbjct: 831  VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 890

Query: 840  LADLQKQFSEILARSKWERDEAQVR-ERKLQEEMALQQEKLATGQEEFRQACERALEARM 898
            LAD++ +F     R K ER+E  ++ + KL+ ++A   +       +           +M
Sbjct: 891  LADMEAKF-----REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL---------TKM 936

Query: 899  NFDKRQHEARIQQMENEIHYLQENL----KSMEEIQGLTDLQLQEA----DEEKERILAQ 950
            N + R  E  +++++ ++    EN     KS+E++    +   QEA    +EEK+ +  +
Sbjct: 937  NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK 996

Query: 951  LRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMK 1010
            L +LEKK +    + QE          K +   ATS+   T    I ++  K+L  T  K
Sbjct: 997  LSDLEKKMETSHNQCQE---------LKARYERATSE-TKTKHEEILQNLQKTLLDTEDK 1046

Query: 1011 INQERAEE---LQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF-RLEMEK--- 1063
            +   R E    LQE E   RK A  A+    AE  +++++ + ++K E    LE  K   
Sbjct: 1047 LKGAREENSGLLQELEEL-RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1105

Query: 1064 ----TGVGTGANSQVLEIEKLNE-----TMERQRTEIARLQ-NVLDLTGSDNKGGFENVL 1113
                  + T   + +  +E+LN+     T+E Q+ E  R +   L    +        + 
Sbjct: 1106 AKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1165

Query: 1114 EEIAELRREVSYQNDYISS 1132
            EE  +L  E+    D ++S
Sbjct: 1166 EENVKLAEELGRSRDEVTS 1184



 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 160/755 (21%), Positives = 328/755 (43%), Gaps = 128/755 (16%)

Query: 1658 ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKL 1717
            E + + + + +  T +++ +++++++++ +L +    + E+      +     EL   + 
Sbjct: 338  ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397

Query: 1718 QHDQRVSELE--------------KTQVAVL----EEKLELENLQQISQQQ---KGEIEW 1756
             HDQ V ELE              + +V +L    EEK ++E+LQ   +++   KG++E 
Sbjct: 398  GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLET 457

Query: 1757 QKQLLERDKREIERMTAESRALQSCVECLSKEKED-----LQEKCDIWEKKLAQTKRVLA 1811
            Q +L     +E+E+     +   +  + L +E ED     + EK  I E +     RV  
Sbjct: 458  QTKLEHARIKELEQSLLFEK---TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQE 514

Query: 1812 AAEENSKMEQ-----------SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
             AE   ++E            S L+++     KL+       R+  SL     A ++  Q
Sbjct: 515  VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ 574

Query: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTK-HQDVLLSEQTRLQKDISEWANRFEDCQ 1919
            ++ +A+ +  E+L+   + L   K  L H  K + DV+   +++L+  I+      E+ +
Sbjct: 575  KEIKALYTATEKLSKENESL---KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK 631

Query: 1920 ----KEEETKQQQLQVLQNEIEENKLKLVQQ-EMMFQRLQKERESEESKLETSKVTLKEQ 1974
                K   T+  +   L+ +IE+ +L    + E +  +   ER +   ++E  +  L + 
Sbjct: 632  VSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKV 691

Query: 1975 QHQLEKELTDQKSKLDQ-----------VLSKVLAAEERVRTLQEEERWCESLEKTLSQT 2023
              + E  L   +SKLD+            L+K+  AE +V+ L+  +  C    K +   
Sbjct: 692  IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF 751

Query: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK------ 2077
              QL   E++L+    +L AL+K +   +++   LR Q     + AEKQ+  L+      
Sbjct: 752  TSQLKATEEKLL----DLDALRKASSEGKSEMKKLRQQL----EAAEKQIKHLEIEKNAE 803

Query: 2078 -----------EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA---RRLM 2123
                       +  +++ + L++NL E  Q    ++KE+  ++    +  E A   +R M
Sbjct: 804  SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 863

Query: 2124 KE----LNQMQYEY----TELKKQMANQKDLE-------RRQMEISDAMRTLKSEVKDEI 2168
            +E    L+Q + ++    ++L+K   N  D+E        R+ ++  A   L++++ + +
Sbjct: 864  QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923

Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
            + S  N +Q L ++  +L   L+  +  E +L+  K N           E  +F Q  I 
Sbjct: 924  KMSGDNSSQ-LTKMNDELR--LKERDVEELQLKLTKAN-----------ENASFLQKSIE 969

Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
            D   + E  +++   + +  K +L   +S      ++ K +T    H+  +++ A  E  
Sbjct: 970  DMTVKAEQSQQEAAKKHEEEKKELERKLSD-----LEKKMETS---HNQCQELKARYERA 1021

Query: 2289 TSTSADSASSPSLSQLESSL--TEDSQLGQNQEKN 2321
            TS    +     L  L+ +L  TED   G  +E +
Sbjct: 1022 TS-ETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 151/664 (22%), Positives = 276/664 (41%), Gaps = 120/664 (18%)

Query: 556  QKSGKEQQLDIMNKQYQQLESR------LDEILSRIAKETEEIKDLEEQLTEGQIAANEA 609
            ++S     L  M+     + SR      L E  SR A++      L+E L E Q    + 
Sbjct: 308  KRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQL 367

Query: 610  L-KKDLEGV-ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
            L ++DLE   ++    ++G I+ +   A       RD  +   Q + E+E + DQL  + 
Sbjct: 368  LAERDLERAEVAKATSHVGEIEQELALA-------RDGHD---QHVLELEAKMDQLRTMV 417

Query: 668  MDAENMRKELA-ELESALQEQHEVNASLQQ---TQGDLS-------AYEAELEARLNLRD 716
              A+  + EL  +LE   ++  ++   +++   T+GDL        A   ELE  L    
Sbjct: 418  EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477

Query: 717  AEANQLKEELEKVTRLTQLEQSALQAELEKE-------------RQALKNALGKAQFSEE 763
             +A++L+ ELE  TR+  + + +   ELEK+             R       G    S  
Sbjct: 478  TKADKLQRELED-TRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 536

Query: 764  KEQENSELHAKLKHLQDDNNLLKQQLKDF-----QNHLNHVVDGLVRPEEVAARVDELRR 818
              QE S L  KL+  + D+      LK+      + H   +       E+++   + L+ 
Sbjct: 537  LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS 596

Query: 819  KLKLGTGEMNIHSPSDVLG--------------KSLADLQKQFSEILARSKWERDEAQVR 864
            KL+    E      SDV+               +++ +L+  FS+ L     E  E + +
Sbjct: 597  KLEHANKE-----NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651

Query: 865  ERKLQEEMALQQEKLATGQEEFRQACERALEA-------------------RMNFDKRQH 905
              K++ +   + E L   Q+  R A  + +EA                   R   DK + 
Sbjct: 652  IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE- 710

Query: 906  EARIQQMENEIHYLQE---NLKSMEEIQGLTDLQLQ---------EADEEKERILAQLRE 953
            +  + +ME+ ++ LQE    +K +E +Q   + Q +         +A EEK   L  LR+
Sbjct: 711  DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770

Query: 954  LEKKKKLEDAKSQEQVFGLDKELKKL---KKAVATSDKLATAELTIAKDQLKSLHGTVMK 1010
               + K E  K ++Q+   +K++K L   K A ++     T EL   + +L +L   + +
Sbjct: 771  ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830

Query: 1011 INQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRL---EMEKTGVG 1067
            ++Q +    +E +    K A+A+ +    +  ++   N L QK EQF +   ++EK    
Sbjct: 831  VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK---- 886

Query: 1068 TGANSQVLEIE-KLNETMERQRTEI---ARLQN----VLDLTGSDNKGGFENVLEEIAEL 1119
                  + ++E K  E  ER+   I    +L+N    ++ ++G DN      + +E+   
Sbjct: 887  --LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-DNSSQLTKMNDELRLK 943

Query: 1120 RREV 1123
             R+V
Sbjct: 944  ERDV 947



 Score = 84.7 bits (208), Expect = 9e-16
 Identities = 102/514 (19%), Positives = 230/514 (44%), Gaps = 74/514 (14%)

Query: 1311 LHCNVPEHHNLENEVSRLEDIMQHLKSKKRE----ERWMRASKRQSEKEMEELHHNIDD- 1365
            LH    + + L +++ +L + +  +++K RE    E  +  +K + E ++ E+     D 
Sbjct: 870  LHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDN 929

Query: 1366 ------LLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI--EKSLKHHEDI 1417
                  +  E +  E +VEEL   + K  +   F+  ++E +  + E   +++ K HE+ 
Sbjct: 930  SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE- 988

Query: 1418 VDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDA 1477
                            E +E +R L++ E ++  +  + +    ++   +R+  +T++  
Sbjct: 989  ----------------EKKELERKLSDLEKKMETSHNQCQELKARY---ERATSETKTKH 1029

Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSD--FQC 1535
            EE+ +  Q+T   L+  + +L+  + +   L Q   + EE+ K+ +K  AA+ ++   Q 
Sbjct: 1030 EEILQNLQKT---LLDTEDKLKGAREENSGLLQ---ELEELRKQADKAKAAQTAEDAMQI 1083

Query: 1536 LSKKKEKLTEELQ----------KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1585
            + +  ++ TE L           KLQ +++  + N   +++ L +S+ LL  +  ++E+ 
Sbjct: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEF 1143

Query: 1586 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV 1645
            + ++ + +Q  A   +QL   +EE              L E L     EVT         
Sbjct: 1144 RKEIETLKQAAAQKSQQLSALQEE-----------NVKLAEELGRSRDEVTSH------- 1185

Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
                ++L  ++  LN Q+ E K + +   ++ ++E+ +LQ  +   S   TE    L+ L
Sbjct: 1186 ----QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1241

Query: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765
            + E   L+G         S ++  +   ++ +L+++NL+   ++ K ++       +   
Sbjct: 1242 RNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1301

Query: 1766 REIER-MTAESRALQSCVECLSKEKEDLQEKCDI 1798
             E ER   ++   L S +  L ++ +DL+ K ++
Sbjct: 1302 DEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEM 1335



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 111/578 (19%), Positives = 236/578 (40%), Gaps = 64/578 (11%)

Query: 54   EQVEIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTK-QDNLALIKSLNLSLSKDGG 112
            +Q+E A++    L+ + +  +   + +    +    KLT  Q+NL+ +  +  +L K+  
Sbjct: 784  QQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 843

Query: 113  -KKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNL 171
              K K+ E  E+ V ++      ++   + KL +  K  + N+  + + K+   EN+ ++
Sbjct: 844  ILKEKFAEASEEAVSVQ-----RSMQETVNKLHQ--KEEQFNMLSSDLEKLR--ENLADM 894

Query: 172  QKLNLAGNEIEHIPVWLGKKLKS--LRVLNLKGNKISSLQDISKLKPLQDLISLILVENP 229
            +      +E E   +   +KL++    ++ + G+  S L  ++    L++      VE  
Sbjct: 895  EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD----VEEL 950

Query: 230  VVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLE--EVERLERDLEKKM---- 283
             + L    +   F  +S+E +  +    Q +QEA ++   E  E+ER   DLEKKM    
Sbjct: 951  QLKLTKANENASFLQKSIEDMTVK--AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008

Query: 284  IETEELKSKQTRFLEEIK----------------NQDKLNKSLKEEAMLQKQSCEELKSD 327
             + +ELK++  R   E K                 +DKL K  +EE     Q  EEL+  
Sbjct: 1009 NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL-KGAREENSGLLQELEELRKQ 1067

Query: 328  LNTKN---------ELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEI 378
             +            ++++Q T E T       + +Q  A  K+  + + L    +    +
Sbjct: 1068 ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA--KLQNELDTLK--ENNLKNV 1123

Query: 379  DKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQ 438
            ++       +     K   F  E   I++ +    +K +    L+ +++ L         
Sbjct: 1124 EELNKSKELLTVENQKMEEFRKE---IETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180

Query: 439  LEDKEKKISAAQTRLSELHDEIEKAEQQILR-ATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
                 +K+   ++ L+    E++K E + ++ A EE   L+++I +       KD   ++
Sbjct: 1181 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK 1240

Query: 498  LSGRLQLVNKLRQEALDLE-----LQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSH 552
            L   + ++      A  L      L+ +K K E+  K  E++  +       S     + 
Sbjct: 1241 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1300

Query: 553  MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
                +  +E Q+D +N     L+ +  ++  ++   +E
Sbjct: 1301 ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 80/345 (23%), Positives = 145/345 (42%), Gaps = 43/345 (12%)

Query: 244  LRSLESLEGQP------VTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFL 297
            L+ LE L  Q        T +D  +  E+ + E+ E L    + K    +      T   
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117

Query: 298  EEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQEL- 356
              +KN ++LNKS KE   ++ Q  EE + ++ T  +   QK+ +L+   ++  +L +EL 
Sbjct: 1118 NNLKNVEELNKS-KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1176

Query: 357  -------AFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409
                   +  K++ +   LN   ++  E+ K   ES +I  +  ++   A+    I    
Sbjct: 1177 RSRDEVTSHQKLEEERSVLN---NQLLEMKKR--ESKFIKDADEEK---ASLQKSISITS 1228

Query: 410  AVQIKKMEPDEQLRNDHMNLRG--------HTPLDTQLEDK---EKKISAAQTRLSELHD 458
            A+  +K    E+LRN+   LRG        H+ + T   DK   E K+   + +L E   
Sbjct: 1229 ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1288

Query: 459  EIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL----- 513
            ++  +        +E ++ +E+ Q+  ++    DL  K    +++ V  + + AL     
Sbjct: 1289 QLSSSSGNTDTQADEDERAQES-QIDFLNSVIVDLQRKNQDLKMK-VEMMSEAALNGNGD 1346

Query: 514  DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKS 558
            DL    +   QE   K+K      I  D  D  D +    +AQ S
Sbjct: 1347 DLN-NYDSDDQEKQSKKKPRLFCDIC-DCFDLHDTEDCPTQAQMS 1389


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  161 bits (408), Expect = 6e-39
 Identities = 230/1064 (21%), Positives = 468/1064 (43%), Gaps = 134/1064 (12%)

Query: 1321 LENEVSRLEDIMQHLK-------SKKREERWMRASKRQSEKEMEELHHNIDDLLQ-EKKS 1372
            LE+EVSR ++ +  ++         K + + +  +K   E ++E      D L + EK++
Sbjct: 325  LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384

Query: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMT-ELEIEKSLKHHEDIVDEIECIEKTLLKR 1431
            L+ + + LH    +R   +  I+  +E  MT E+  ++S+     +  E+E I +T    
Sbjct: 385  LQLKAK-LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT---- 439

Query: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
             SEL EA +     E       E T + + K     +SL +T  +        +  A  +
Sbjct: 440  -SELSEAPQKSLGHE-----VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493

Query: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
            +K +++ + L            K+ EIL+  N+IV  K S   C +  K+ + E+ Q L+
Sbjct: 494  LKMEKENQRLS-----------KKVEILE--NEIVQEKQSLQNCQNLSKDLMKEKAQ-LE 539

Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ------QQEMAVLDRQLGH 1605
            K IE    N +  +++L++    L    + L + +SQ++++      ++E  +L   +  
Sbjct: 540  KTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAEARVKDIEKENKILHESIKE 598

Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGET--EVTEKCNHIREVKSLLEELSFQKGELNVQI 1663
               +L  ++    Q K +L+     GE   E+  + +H+ +   LL     QK   N++I
Sbjct: 599  TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL-----QKKITNLKI 653

Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHD 1720
            +  K +       +E+E   L+   R++ K     KN+   L+ L+ EN +L    L+  
Sbjct: 654  TCEKIEA------LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707

Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            + V  L+   + + + +LE + L+   +Q K  +E  K   ++ +R           L+ 
Sbjct: 708  RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER-----------LEV 756

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK------- 1833
              + L  E + LQ+  +   KK+ Q +  L   E  ++  Q NLE+L+++ ++       
Sbjct: 757  SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 1834 ---LQQELDQLNRDKLSLHNDISAMQQQ-------LQEKREAVNSLQEELANVQDHLNLA 1883
               L+QE  QL +DK  L  +   ++QQ       L+E    + +L++E   +   + + 
Sbjct: 817  NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876

Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQ---QLQVLQNEIEE-- 1938
            K+  +   + +        R   DI       ED   E+   QQ    L+ L +E+E+  
Sbjct: 877  KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936

Query: 1939 -NKLKLVQQEM-----MFQRLQKERESEESK-LETSKVTLKEQQHQLEKELTDQKSKLDQ 1991
             NK +L+  E       ++ L+ + ES   K LE  +  +   + +LE E T+   +L Q
Sbjct: 937  LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQLRQ 995

Query: 1992 VLSKVLAAEERVRTLQEEERWCES---LEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
             L  V    E ++  Q+EER  +S   +    ++ +R+  E  ++L++    L+ +++  
Sbjct: 996  ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055

Query: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
             +++A+   L+ Q         KQ+ +    L+ Q   L++  +  +++N+ +Q + A +
Sbjct: 1056 ATLQAEKQALKTQL--------KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1107

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQ----MANQKDL---------ERRQMEISD 2155
            ++     + ++  LM +  Q+  + + L+ +    +  ++DL         +  ++E+  
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167

Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGP 2215
              +  + E       +LK+ ++ L     DLE    +    +G+LE L++ L     +  
Sbjct: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1227

Query: 2216 FEEKLNFSQVHIMDEHWRGEALREKLRHREDRL--KAQLRHCMSKQAEVLIKGKR----Q 2269
             E K N   V    +   GE   ++L H   +L  + ++     K  + L+   +    +
Sbjct: 1228 LENK-NHETVAAEYKKLCGE--NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR 1284

Query: 2270 TEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQ 2313
             E     L+ Q   L   +TST  ++     LSQL+ +L E+++
Sbjct: 1285 LEAEFSKLKEQYQQLD--ITSTKLNN-QCELLSQLKGNLEEENR 1325



 Score =  144 bits (362), Expect = 1e-33
 Identities = 198/942 (21%), Positives = 420/942 (44%), Gaps = 109/942 (11%)

Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
            +KR    +     LA+A++++   +++ +   E+  D K+ L Q E +     +R Q+  
Sbjct: 240  MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL----KRLQQEN 295

Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
            +NL+   +  R  + +   L +  ++ +++  E+++    +  D +    + E+L E+ Q
Sbjct: 296  MNLLSDARSARMYRDELDALREKAVRVDKLESEVSR-YKERLHDIEFYKARVEELKEDNQ 354

Query: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
             L +   M E           E       K  ELEK   Q+ ++  +M  ++R +  KK 
Sbjct: 355  VLLETKTMLEDQ--------LEGTRARSDKLHELEKENLQLKAKLHDME-MERDMDRKKI 405

Query: 1609 ELHLLQGSM---VQAKADLQEALRLG-ETEVTEKCNHIREVKSLLEELSFQKGELNVQIS 1664
            E  L++ +M   +  K  + E+L LG E E   + + + E     + L  +  EL     
Sbjct: 406  E-ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ--KSLGHEVNEL----- 457

Query: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
               T   L+K E+E +          ++K   EL+  +D ++    ++  ++ ++ +   
Sbjct: 458  ---TSSRLLKLEMENQ---------SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505

Query: 1725 ELEKTQVAVLEEKLELENLQQISQ---QQKGEIEWQ-KQLLERDKREIERMTAESRALQS 1780
            ++E  +  +++EK  L+N Q +S+   ++K ++E   + L E  +R+I+ +  E+  L  
Sbjct: 506  KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
             V  L   ++  Q   +   K + +  ++L    E+ K   S L K+E   R++++EL+ 
Sbjct: 566  TVSSL---RQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEH 619

Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
              ++K     ++      L+++ E    LQ+++ N    L +  + +    +    L  E
Sbjct: 620  Y-KEKGERAEELENELHHLEKENEL---LQKKITN----LKITCEKIEALEQENSELERE 671

Query: 1901 QTRLQKDISEWAN---RFEDCQKEEETKQQQLQVLQNEIEENK---LKLVQQEMMFQRLQ 1954
              +L+K +  + N   + E  +KE     ++   L+  +E  K   +K+ Q ++  + L+
Sbjct: 672  NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731

Query: 1955 KERESEESKLETSKVTLKE-------------QQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
             E+E  +  LE  K + K+             +  +L+K L +   K+ Q+ S++   E 
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 2002 RVRTLQE-------EERWCESLE---KTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
              +TLQ+         +  E LE   K+L Q   QL + ++QL +++  L    +  D+ 
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851

Query: 2052 RADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELV 2111
              + ++       E K   K++   KE+  ++  +LEK   E  +  +   K + T+   
Sbjct: 852  LEENNVKIGNLEKENKTLSKEIGIYKESC-VRLKELEKENKELVKRATIDIKTLVTLRED 910

Query: 2112 AQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDA-MRTLKSEVKDEIRT 2170
                  + +++  +L ++ +   EL+K   N++ L   +    D+  + L+S+++  ++ 
Sbjct: 911  LVSEKLKTQQMNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967

Query: 2171 SLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM-- 2228
            SL+   + +  L A LE     N+ L  EL+++K+N    + +   EE++  S   I   
Sbjct: 968  SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGE 1026

Query: 2229 DEHWRGEA---LREKLRHRE-----DRLKAQL---RHCMSKQAEVLIKGKRQTEGTLHSL 2277
            D  W  E+    RE L+ ++     +R  A L   +  +  Q + L       +  + +L
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086

Query: 2278 RRQVDALGELVTSTSADSA-----SSPSLSQLESSLTEDSQL 2314
            +RQ  +L E  T+    +A     +S   SQ  S + +++QL
Sbjct: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128



 Score =  124 bits (311), Expect = 1e-27
 Identities = 189/876 (21%), Positives = 380/876 (43%), Gaps = 106/876 (12%)

Query: 1318 HHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
            H +++   S+L  I    +  K+E   +   K + E+  EEL + +  L +E + L+ ++
Sbjct: 593  HESIKETSSKLSKIEFEKRQIKKE---LEHYKEKGERA-EELENELHHLEKENELLQKKI 648

Query: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELRE 1437
              L  T +K +  +     N E      +++K+L   +++  ++E +E    K  S+L E
Sbjct: 649  TNLKITCEKIEALE---QENSELERENRKLKKTLDSFKNLTFQLESLE----KENSQLDE 701

Query: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD-Q 1496
             +  L      L C               K + LQ E+   E E+   +  + L+KA  +
Sbjct: 702  ENLELRRNVESLKC------------ASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749

Query: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            +   L+   + L+    + ++ L+  NK +   +S+ Q L  + + L + L++L      
Sbjct: 750  KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL------ 803

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
              +     L+ L++    L+ + ++LEK K Q+  + + +           EE ++  G+
Sbjct: 804  --KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861

Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ----ISERKTQLTL 1672
            + +    L + + +      E C  ++E++   +EL  ++  ++++    + E      L
Sbjct: 862  LEKENKTLSKEIGI----YKESCVRLKELEKENKEL-VKRATIDIKTLVTLREDLVSEKL 916

Query: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS-ELEKTQV 1731
              Q++  + E L   L ++  +K  L +         ++L   KL+   + S E+++ ++
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976

Query: 1732 AVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
            A LE +  LE     +QQ + E++  K+  E  K+  +    E R +QS      ++ + 
Sbjct: 977  AALEAR--LEESTNYNQQLRQELKTVKKNYEALKQRQD----EERMVQSSPPISGEDNK- 1029

Query: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
                   WE++  +T R L   ++     + N   L+   + L+ +L QL     +L   
Sbjct: 1030 -------WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082

Query: 1852 ISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911
            I A+Q+Q    +E   +LQ + A +Q   +               LL +Q+ L+      
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE------ 1136

Query: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
             N  E   KE E     L+ L + + ++  KL   E++ +R   E ES  SK      TL
Sbjct: 1137 -NENESVIKERE----DLKSLYDSLIKDHEKL---ELLHERQASEYESLISK----HGTL 1184

Query: 1972 KEQQHQLEKELTDQKSKLDQVLSKVLAAE--ERVRTLQEEERWCESL-EKTLSQTKRQLS 2028
            K     LE E  D + + +Q+L +    E  E++  +++E+   E+   +T++   ++L 
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244

Query: 2029 EREQQLVEKSGELLALQKEADSMRADF----SLLRNQFLTERKKAEKQVASLKEALKIQR 2084
                +L     +LL   KE + ++ D     SLL N  L E+ + E + + LKE    Q 
Sbjct: 1245 GENDRLNHTYSQLL---KETEVLQTDHKNLKSLLNNSKL-EQTRLEAEFSKLKE----QY 1296

Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQMQYEYTELKKQMA 2141
             QL+  +   K  N C        EL++Q   +  E  R L+ ++  +  +   L +Q  
Sbjct: 1297 QQLD--ITSTKLNNQC--------ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1346

Query: 2142 NQKDL----ERRQMEISDAMRTLKSEVKDEIRTSLK 2173
              KDL    +R+ ++  + +R  K +++++I    K
Sbjct: 1347 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1382



 Score =  107 bits (267), Expect = 1e-22
 Identities = 159/790 (20%), Positives = 344/790 (43%), Gaps = 139/790 (17%)

Query: 445  KISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL-- 502
            +++ A+ ++  L  E+E+  +Q+L   +E +Q+E  I+LK++ +   +LL    S R+  
Sbjct: 252  ELADAKAKIRRLRQELEEKTEQLLDCKQELEQME--IELKRLQQENMNLLSDARSARMYR 309

Query: 503  QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
              ++ LR++A    ++++K + E++  ++ + D++     ++     +  +   K+  E 
Sbjct: 310  DELDALREKA----VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365

Query: 563  QLD----------IMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK 612
            QL+           + K+  QL+++L ++      + ++I++L E+    ++A  +++ +
Sbjct: 366  QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425

Query: 613  DL------------EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
             L              +    Q+ LG    + T ++    KL  E ++L + + E+    
Sbjct: 426  SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR--LLKLEMENQSLTKTVEELRTTV 483

Query: 661  DQLE-----IVAMDAENMR--KELAELESALQEQHEVNASLQQTQGDLSAYEAEL----- 708
            D +E     I+ M+ EN R  K++  LE+ + ++ +   + Q    DL   +A+L     
Sbjct: 484  DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543

Query: 709  ------EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL-------KNAL 755
                  E ++ + + E   L + +  + + +Q+   A   ++EKE + L        + L
Sbjct: 544  TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603

Query: 756  GKAQFS-----------EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLV 804
             K +F            +EK +   EL  +L HL+ +N LL++++     +L    + + 
Sbjct: 604  SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI----TNLKITCEKIE 659

Query: 805  RPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEI------------- 850
              E+  + ++   RKLK       N+    + L K  + L ++  E+             
Sbjct: 660  ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719

Query: 851  LARSKWERDEAQVRERKLQEEMAL------QQEKLATGQEEFRQACERALEARMNFDKR- 903
            +A+ + E  E +  + +L++ + L      + E+L    +      +R  +   N +K+ 
Sbjct: 720  MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779

Query: 904  -QHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
             Q E+ +Q +E E   LQ+NL+ ++    ++  +L++ ++E + +  +  +LEK KK   
Sbjct: 780  QQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKK--- 832

Query: 963  AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMK---INQERAEEL 1019
                     L+KE K+L++     D     E  +    L+  + T+ K   I +E    L
Sbjct: 833  --------QLEKENKRLRQQAEIKD-TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL 883

Query: 1020 QEAERFSRKAAQAARDLTRAEAEIELLQNLL------RQKGEQFRLEMEKTGVGTGANSQ 1073
            +E E+ +++  +      RA  +I+ L  L       + K +Q   ++EK          
Sbjct: 884  KELEKENKELVK------RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL--------- 928

Query: 1074 VLEIEKLNETMER-----QRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQND 1128
              E+EK+    ER     Q T+ +R + +     S  K   E   E+IA L   +    +
Sbjct: 929  THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988

Query: 1129 YISSMADPFK 1138
            Y   +    K
Sbjct: 989  YNQQLRQELK 998



 Score =  107 bits (266), Expect = 2e-22
 Identities = 205/964 (21%), Positives = 407/964 (42%), Gaps = 158/964 (16%)

Query: 260  RQEAFERFSLE------EVERLERDLEKKM--------------IETEELKSKQTRFLEE 299
            R E+ +  S+E      ++ RL ++LE+K               IE + L+ +    L +
Sbjct: 242  RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 300  IKN----QDKLNKSLKEEAM--------------------LQKQSCEELKSD----LNTK 331
             ++    +D+L+ +L+E+A+                      K   EELK D    L TK
Sbjct: 302  ARSARMYRDELD-ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360

Query: 332  NELLKQKTIELTRA-CQKQYELEQELAFYKI---------DAKFEPLNYYPSEYAEIDKA 381
              L  Q  +E TRA   K +ELE+E    K          D   + +     E   ++ A
Sbjct: 361  TMLEDQ--LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418

Query: 382  P----DESPYIG--KSRYKRNMFATES------YIIDSAQAVQIKKMEPD--------EQ 421
                 DES ++G    +  R    +E+      + ++   + ++ K+E +        E+
Sbjct: 419  QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478

Query: 422  LRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL-EEA 480
            LR    ++ G+     ++E + +++S    ++  L +EI + +Q +       K L +E 
Sbjct: 479  LRTTVDSVEGNASKILKMEKENQRLS---KKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535

Query: 481  IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ--- 537
             QL+K  E  ++   +Q+      + +   E L+  +   +Q+ +I+ + + +KD++   
Sbjct: 536  AQLEKTIETLRENSERQIK-----ILEQENEHLNQTVSSLRQRSQISAEAR-VKDIEKEN 589

Query: 538  -IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE--EIKD 594
             I  +S+     K S ++ +K   +++L+   ++ ++ E  L+  L  + KE E  + K 
Sbjct: 590  KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKI 648

Query: 595  LEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT 654
               ++T  +I A E    +LE     L++ L + K    Q ++    L  E   L +   
Sbjct: 649  TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENL 704

Query: 655  EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNL 714
            E+ +  + L+  +M    ++ E  ELES   E+ ++   L+  +      E  LE     
Sbjct: 705  ELRRNVESLKCASMKMAQLQLENKELES---EKEQLKKGLELLKASFKKTE-RLEVSYQG 760

Query: 715  RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK---------- 764
             D E  +L++ LE   +  Q  +S LQ +LE E Q L+  L + + S ++          
Sbjct: 761  LDIENQRLQKTLENSNKKIQQLESELQ-DLEMENQTLQKNLEELKISSKRLEQLEKENKS 819

Query: 765  -EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLG 823
             EQE S+L    K L+ +N  L+QQ +     L          EE   ++  L ++ K  
Sbjct: 820  LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL----------EENNVKIGNLEKENKTL 869

Query: 824  TGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMALQQ-----E 877
            + E+ I+  S V    L +L+K+  E++ R+  + +    +RE  + E++  QQ     E
Sbjct: 870  SKEIGIYKESCV---RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926

Query: 878  KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQL 937
            KL    E+     ER L    + D  +++    ++E+    L+++L+  EE     + +L
Sbjct: 927  KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST---LKKSLEIKEEKIAALEARL 983

Query: 938  QEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTI 996
            +E+    +++  +L+ ++K  + L+  + +E++      +           +  T EL  
Sbjct: 984  EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1043

Query: 997  AKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
             KD+L       +++ +  A    E +    +  Q        +A+I  LQ       EQ
Sbjct: 1044 VKDRL-------IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096

Query: 1057 FRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEI 1116
                       T   +Q  +++  N T+  Q T +      L +  S  +   E+V++E 
Sbjct: 1097 ----------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1146

Query: 1117 AELR 1120
             +L+
Sbjct: 1147 EDLK 1150



 Score =  104 bits (260), Expect = 9e-22
 Identities = 189/832 (22%), Positives = 349/832 (41%), Gaps = 121/832 (14%)

Query: 265  ERFSLEEVERLERDLEK------KMIET-EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
            E+ SL+  + L +DL K      K IET  E   +Q + LE+    + LN+++       
Sbjct: 517  EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ--ENEHLNQTVSSLRQRS 574

Query: 318  KQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE 377
            + S E    D+  +N++L +   E +    K       + F K   K E L +Y  +   
Sbjct: 575  QISAEARVKDIEKENKILHESIKETSSKLSK-------IEFEKRQIKKE-LEHYKEKGER 626

Query: 378  IDKAPDESPYIGKSRYKRNMFATESYII-DSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
             ++  +E  ++ K         T   I  +  +A++ +  E + + R     L     L 
Sbjct: 627  AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686

Query: 437  TQLEDKEKKISAAQTRLSELHDEIEK---AEQQILRATEEFKQLE-EAIQLKK------- 485
             QLE  EK+ S       EL   +E    A  ++ +   E K+LE E  QLKK       
Sbjct: 687  FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746

Query: 486  ---------ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL 536
                     +S  G D+  ++L   L+  NK  Q+   LE +++  + E    QK +++L
Sbjct: 747  SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ---LESELQDLEMENQTLQKNLEEL 803

Query: 537  QIAIDSLDSKDPKHSHMKAQKSGKEQ---QLDIMNKQYQQ----LESRLDEILSRIAKET 589
            +I+   L+  + ++  ++ + S  E+   QL+  NK+ +Q     ++ L+E   +I    
Sbjct: 804  KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863

Query: 590  EEIKDLEEQL---TEGQIAANEALKKDLEGV---------ISGLQEYLGTIKGQATQAQN 637
            +E K L +++    E  +   E  K++ E V         +  L+E L + K +  Q  N
Sbjct: 864  KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923

Query: 638  ECRKLRDEKETL---LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
            +  KL  E E +    +RL   EQ  D      ++        ++LES L++      SL
Sbjct: 924  DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE--------SKLESTLKK------SL 969

Query: 695  QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER--QALK 752
            +  +  ++A EA LE   N       QL++EL+ V +       AL+   ++ER  Q+  
Sbjct: 970  EIKEEKIAALEARLEESTNYN----QQLRQELKTVKK----NYEALKQRQDEERMVQSSP 1021

Query: 753  NALGKAQFSEEKEQENSELHAKLKH-----------LQDDNNLLKQQLKDFQNHLNHVVD 801
               G+    E + QE +    K+K            LQ +   LK QLK  +   N++  
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1081

Query: 802  GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR--SKWERD 859
             ++  +     + E    L+    ++ +   +  L      L  Q +++L +  S    +
Sbjct: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVE--NSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139

Query: 860  EAQVRERK----LQEEMALQQEKLATGQEEFRQACE-RALEARMNFDKRQH---EARIQQ 911
            E+ ++ER+    L + +    EKL    E  RQA E  +L ++    K  H   E   + 
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHE--RQASEYESLISKHGTLKSAHKNLEVEHRD 1197

Query: 912  MENEIHYLQENLKSMEEIQGLTDLQLQE---ADEEKERILAQLREL-EKKKKLEDAKSQ- 966
            +E+  + L +    +E+++ +  ++ ++    ++  E + A+ ++L  +  +L    SQ 
Sbjct: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257

Query: 967  ---EQVFGLD-KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE 1014
                +V   D K LK L            AE +  K+Q + L  T  K+N +
Sbjct: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 146/678 (21%), Positives = 292/678 (43%), Gaps = 95/678 (14%)

Query: 505  VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL 564
            V KL    L   +Q +K+++ I    + I+ L       D+K    +H++     +E   
Sbjct: 121  VKKLLLLLLGCAVQCQKKEEFI----ERIQGLDF-----DTKAAVAAHIQEVTHNQENVF 171

Query: 565  DIMNKQYQQLESR-LDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKD----LEGVIS 619
            D+   +   +    ++ +L  +A   + + D  ++ +E  I  +E  ++D    L    S
Sbjct: 172  DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE--ERDGLHFLPHASS 229

Query: 620  GLQEYLGT-----------IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI--V 666
              Q   G+           +  +   A+ + R+LR E E   ++L + +QE +Q+EI   
Sbjct: 230  SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289

Query: 667  AMDAENMRKELAELESALQEQHEVNA------SLQQTQGDLSAYEAELEARLNLRDAEAN 720
             +  ENM   L++  SA   + E++A       + + + ++S Y+  L   +    A   
Sbjct: 290  RLQQENMNL-LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH-DIEFYKARVE 347

Query: 721  QLKEE----LEKVTRL-TQLEQSALQA----ELEKERQALKNALGKAQFSEEKEQENSEL 771
            +LKE+    LE  T L  QLE +  ++    ELEKE   LK  L       + E E    
Sbjct: 348  ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL------HDMEMERDMD 401

Query: 772  HAKLKHLQDDN---NLLKQQLKDFQNHLNHVVDGLVRPEEVAA--------RVDEL--RR 818
              K++ L ++N    + ++Q  D   HL   ++ + R  E++          V+EL   R
Sbjct: 402  RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461

Query: 819  KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878
             LKL     ++    + L  ++  ++   S+IL   K E      +   L+ E+  +++ 
Sbjct: 462  LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQS 520

Query: 879  LATGQEEFRQACER--ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT-DL 935
            L   Q   +   +    LE  +   +   E +I+ +E E  +L + + S+ +   ++ + 
Sbjct: 521  LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580

Query: 936  QLQEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAEL 994
            ++++ ++E + +   ++E   K  K+E  K Q     + KEL+  K+    +++L     
Sbjct: 581  RVKDIEKENKILHESIKETSSKLSKIEFEKRQ-----IKKELEHYKEKGERAEELENELH 635

Query: 995  TIAKD-QLKSLHGTVMKINQERAEELQ----EAERFSRKAAQAARDLTRAEAEIELLQNL 1049
             + K+ +L     T +KI  E+ E L+    E ER +RK  +          ++E L+  
Sbjct: 636  HLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE 695

Query: 1050 LRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGG 1108
              Q  E+  LE+ +       A+ ++ +++  N+ +E ++ ++ +   +L       K  
Sbjct: 696  NSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL-------KAS 747

Query: 1109 FENVLEEIAELRREVSYQ 1126
            F+         R EVSYQ
Sbjct: 748  FKKT------ERLEVSYQ 759



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 159/778 (20%), Positives = 318/778 (40%), Gaps = 154/778 (19%)

Query: 53   CEQVEIADENNMLLDYQDHK---GADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSK 109
            CE++E  ++ N  L+ ++ K     DS   + +  E+L K+ ++ D        NL L +
Sbjct: 655  CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE------NLELRR 708

Query: 110  DGGKKFKYIENLEKCVKLEVLNLSYN---LIGKIEKLDKLLKLRELNLSYNKISKIEGIE 166
            +       +E+L KC  +++  L      L  + E+L K L+L  L  S+ K  ++E   
Sbjct: 709  N-------VESL-KCASMKMAQLQLENKELESEKEQLKKGLEL--LKASFKKTERLE--- 755

Query: 167  NMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILV 226
               + Q L++    ++       KK++ L          S LQD+              +
Sbjct: 756  --VSYQGLDIENQRLQKTLENSNKKIQQLE---------SELQDLE-------------M 791

Query: 227  ENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
            EN   TL   L+      + LE LE +  + +           +E  +LE+D  KK +E 
Sbjct: 792  ENQ--TLQKNLEELKISSKRLEQLEKENKSLE-----------QETSQLEKD--KKQLEK 836

Query: 287  EELKSKQTRFLEE---------IKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQ 337
            E  + +Q   +++         I N +K NK+L +E  + K+SC  LK       EL+K+
Sbjct: 837  ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896

Query: 338  KTIELTRACQKQYELEQELA--------FYKIDAKFEPLNYYPSEYAEIDKAPDESPY-I 388
             TI++      + +L  E            K+  + E +          +++ D+S Y +
Sbjct: 897  ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956

Query: 389  GKSRYKRNMFATESYIIDSAQAVQIKKMEP---DEQLRNDHMNLRGHTPLDTQLEDKEKK 445
             +S+ +  +  +     +   A++ +  E    ++QLR +   ++ +     Q +D+E+ 
Sbjct: 957  LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016

Query: 446  ISAAQTRLSELHDEIEKAEQQILRATEEFK-QLEEAIQLKKISEAGKDLLYKQLSGRLQL 504
            + ++   +S   ++ E+  Q+  R   + K +L E  +     +A K  L  QL      
Sbjct: 1017 VQSSPP-ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075

Query: 505  VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP----KHSHMKAQKSGK 560
             N L+ + L L+ Q    +++    Q +   LQ+   +L+S+      +++ +  Q+S  
Sbjct: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135

Query: 561  EQQLDIMNKQYQQLESRLDEILS----------RIAKETEEI-----------KDLEEQL 599
            E + + + K+ + L+S  D ++           R A E E +           K+LE + 
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195

Query: 600  TEGQIAANEALKK-----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL----- 649
             + +   N+ LK+     DLE ++   QE +            E +KL  E + L     
Sbjct: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS 1255

Query: 650  -LQRLTEV-----------------------------EQERDQLEIVAMDAENMRKELAE 679
             L + TEV                             +++  QL+I +    N  + L++
Sbjct: 1256 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1315

Query: 680  LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
            L+  L+E++     L Q Q  +      LE  +  +D    + ++ ++K+  L + ++
Sbjct: 1316 LKGNLEEEN--RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1371



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 89/402 (22%), Positives = 152/402 (37%), Gaps = 51/402 (12%)

Query: 1318 HHNLENEVSRLED-IMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            H NLE E   LED   Q LK K + E   +  K + EK + E + N + +  E K L  E
Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGE 1246

Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
             + L+ T  +  ++        E L T+ +  KSL ++  +              ++ L 
Sbjct: 1247 NDRLNHTYSQLLKE-------TEVLQTDHKNLKSLLNNSKL-------------EQTRLE 1286

Query: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
                 L E   +L  T  K  N  E  +  K +L       EE  R   +    L+  ++
Sbjct: 1287 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL-------EEENRHLLDQIQTLMLQNR 1339

Query: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
             L     ++KDL    ++Q + + ++N+           L ++KEKL E++    K  + 
Sbjct: 1340 TLLEQNMESKDL--FHVEQRQYIDKLNE-----------LRRQKEKLEEKIMDQYKFYDP 1386

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKS-QVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
            +      +   LK  +++   K    E+ KS  +T  + + +    QL H+       Q 
Sbjct: 1387 SPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDS-----QD 1441

Query: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNV--QISERKTQLTLI 1673
            S       L++   LG T+ +   N + +   L  + +     L V   IS  K +  L 
Sbjct: 1442 SSSVGSNSLEDGQTLG-TKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELG 1500

Query: 1674 KQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
                     N   V         +L N  D    E+   QG+
Sbjct: 1501 AMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGV 1542


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  159 bits (403), Expect = 2e-38
 Identities = 216/1045 (20%), Positives = 453/1045 (43%), Gaps = 138/1045 (13%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ +  + ++     + A KR+ E E  EL  +IDDL      +E   +E H T  
Sbjct: 918  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE---KEKHATEN 974

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE-------KTLLKRRSELRE 1437
            K +   + + G  E++      +K+L+  H+  +D+++  E       KT  K   ++ +
Sbjct: 975  KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVED 1034

Query: 1438 ADRLLAEAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
             +  L E E +L    E+ K  +E     A+ S+L  E+D ++L+ R       L K D 
Sbjct: 1035 LESSL-EQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER-------LKKKDF 1086

Query: 1497 QLRSLQADAKDLE------QHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
            +   LQ+  +D +      Q KIK+ +  ++E+ + + A+ +      K++     EL++
Sbjct: 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE 1146

Query: 1550 LQKDIEMA--------ERNEDHHLQVLK----------ESEVLLQAKRAE----LEKLKS 1587
            L + +E A        E N+    + LK          + E ++ A R +    + +L  
Sbjct: 1147 LSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE 1206

Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIRE 1644
            Q+ + Q+    L+++    K E+  L  SM    ++KA+L++  R  E +++E      E
Sbjct: 1207 QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE 1266

Query: 1645 VKSLLEELSFQK-------GELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKH 1694
            ++  L EL+ QK       GEL+ Q+ E+++   QL+  KQ   ++ E L+  L + +K 
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326

Query: 1695 KTELKNILDMLQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQ 1745
            K  L + L   Q   H+   L+ Q++         QR      ++VA    K E + +Q+
Sbjct: 1327 KNALAHAL---QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1383

Query: 1746 ISQQQKGEIEWQKQL----------------LERDKR----EIERMTAESRALQSCVECL 1785
              + ++ + +  ++L                LE+ K+    E+E +  +     S    L
Sbjct: 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443

Query: 1786 SKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
             K++ +  +    W+ K  +++  L A+ + S+   + L KL+    +   +L+ + R+ 
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503

Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQE-------ELANVQDHLNLAKQDLLHTTKHQDVLL 1898
             +L  +I+ + +Q+ E  + ++ L++       E A++Q  L  A+  L H       + 
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563

Query: 1899 SEQTRLQKDIS-EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKER 1957
             E T+++ +I  + A + E+ ++ +   Q+ ++ +Q+ ++      V+      RL+K+ 
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE----VRSRNEAIRLKKKM 1619

Query: 1958 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLE 2017
            E + +++E   + L     Q  + L   +S   Q+    L  ++ +R  ++         
Sbjct: 1620 EGDLNEIE---IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED--------- 1667

Query: 2018 KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
                  K QL+     +VE+   L  LQ E + +RA       Q    RK AE+++    
Sbjct: 1668 -----LKEQLA-----IVERRANL--LQAEVEELRATL----EQTERARKLAEQELLDSN 1711

Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELK 2137
            E +++  +Q    +  +K+  + + +  + +E  ++D      +  K +        ELK
Sbjct: 1712 ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK 1771

Query: 2138 KQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLE 2197
            K+      LER +  +   ++ L+  + +  + +LK   + + +L      I E    LE
Sbjct: 1772 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLET---RIRELEFELE 1828

Query: 2198 GELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMS 2257
            GE +   E++          ++L +          R + L +KL+ +    K Q      
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEA-D 1887

Query: 2258 KQAEVLIKGKRQTEGTLHSLRRQVD 2282
            +QA   +   R+ +  L     + D
Sbjct: 1888 EQANAHLTKFRKAQHELEEAEERAD 1912



 Score =  159 bits (401), Expect = 4e-38
 Identities = 214/1015 (21%), Positives = 447/1015 (44%), Gaps = 139/1015 (13%)

Query: 1425 EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
            EK +   + E ++    LA++E++    +EK    V++  D +   LQ ++++E L   A
Sbjct: 847  EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ---LQVQAESENL-LDA 902

Query: 1485 QETAVNLVKADQQL----RSLQADAKDLEQ---------HKIKQE--EILKEINKI---V 1526
            +E    L+KA  QL    + +   A+D E+          K++ E  E+ K+I+ +   +
Sbjct: 903  EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962

Query: 1527 AAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESEVLLQAKRAEL 1582
            A  + +      K + LTEEL  L + I    R     ++ H Q L +    LQA+  ++
Sbjct: 963  AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDD----LQAEEDKV 1018

Query: 1583 EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHI 1642
              L    +  +Q++  L+  L  +K+    L+  + + K  L+  L+L +  + +  N  
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKK----LRVDLERNKRKLEGDLKLAQESILDLENDK 1074

Query: 1643 REVKSLLEELSFQKGELNVQISERKT--------------QLTLIKQEIEKEEENLQVVL 1688
            +++   L++  F+  +L  ++ + +T              ++  +++EIE E        
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134

Query: 1689 RQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSELEKTQVAVLEE 1736
            +Q S +  EL+ + + L         Q+E     E + LKL+ D   + L+   +     
Sbjct: 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194

Query: 1737 KLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKC 1796
            K   +++ ++  +Q   ++  KQ LE++K E +    E   L S +E +SK K +L++ C
Sbjct: 1195 KKHADSVAELG-EQIDNLQRVKQKLEKEKSEFK---LEIDDLSSSMESVSKSKANLEKIC 1250

Query: 1797 DIWEKKLAQTK-------RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLH 1849
               E +L++ +       R L+         Q+   +L   + + +  + QL+R K +  
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310

Query: 1850 NDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDIS 1909
                 +++QL+E+ +A N+L   L + +   +L ++      + +  L    ++   +++
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370

Query: 1910 EWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQRLQKERES-- 1959
            +W  ++E    Q+ EE ++      Q+LQ  + ++E    K    E   QRLQ E E   
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLM 1430

Query: 1960 -EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE--------E 2010
             +  +  +    L ++Q   +K L + K+K ++  +++ A+ +  R+L  E        E
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490

Query: 2011 RWCESLEKTLSQTK---RQLSEREQQLVEKS---GELLALQKEADSMRADFSLLRNQFLT 2064
               + LE    + K   +++++  +Q+ E      EL   +K+ +  +AD  L   +   
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550

Query: 2065 ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKE-MATIELV--AQDNHERAR- 2120
              +  E ++  ++  L   +S++++ + E+ +E   +++    T+E +  A D   R+R 
Sbjct: 1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN 1610

Query: 2121 ---RLMK----ELNQMQYEYTELKKQMAN--------QKDLERRQMEISDAMRTLKSEVK 2165
               RL K    +LN+++ + +   +Q A         Q  L+  Q+ + DA+R  + ++K
Sbjct: 1611 EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG-QEDLK 1669

Query: 2166 DEIRTSLKNLNQFLPELPADLEAILERNENLE--GELESLKEN----LPFTMNEGPFEEK 2219
            +++    +  N    E+  +L A LE+ E      E E L  N    L  T N      K
Sbjct: 1670 EQLAIVERRANLLQAEV-EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK 1728

Query: 2220 LNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAEV---LIKGKRQT 2270
                +  +M      E      R+ E++ K      A +   + K+ +    L + K+  
Sbjct: 1729 KKL-ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787

Query: 2271 EGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQEKNASA 2324
            E T+  L+ ++D   +L     A       + +LE+ + E + +L   Q+KN  +
Sbjct: 1788 EQTVKDLQHRLDEAEQL-----ALKGGKKQIQKLETRIRELEFELEGEQKKNTES 1837



 Score =  126 bits (316), Expect = 3e-28
 Identities = 213/943 (22%), Positives = 407/943 (43%), Gaps = 129/943 (13%)

Query: 270  EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
            EE ++ + +L K   + +EL+ K    ++E KN  +L    + E +L  ++ C++L   +
Sbjct: 855  EEFQKTKDELAKSEAKRKELEEKLVTLVQE-KNDLQLQVQAESENLLDAEERCDQL---I 910

Query: 329  NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
              K +L + K  E+T   + + E+  EL   K   K E       E +E+ K  D+   +
Sbjct: 911  KAKFQL-EAKIKEVTERAEDEEEINAELTAKK--RKLE------DECSELKKDIDDLE-L 960

Query: 389  GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISA 448
              ++ ++   ATE+ + +  + +        +  R        H      L+ +E K+++
Sbjct: 961  TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020

Query: 449  AQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLS------GRL 502
                 S+L  ++E  E  +    E+ K+L   ++  K    G DL   Q S       + 
Sbjct: 1021 LNKTKSKLEQQVEDLESSL----EQEKKLRVDLERNKRKLEG-DLKLAQESILDLENDKQ 1075

Query: 503  QLVNKLRQEALDL-ELQMEKQKQEIAGKQ--KEIKDLQIAIDSLDSKDPKHSHMKAQKSG 559
            QL  +L+++  +  +LQ + + ++  G Q  K+IK+LQ  I+ L+ +       +A ++ 
Sbjct: 1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE---RATRAK 1132

Query: 560  KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVIS 619
             E+Q     ++ ++L  RL+E     + + E  K  E +  + +    EA  +    V +
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192

Query: 620  GLQEYLGTIKGQATQAQNECR-KLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELA 678
              +++  ++     Q  N  R K + EKE    +L E++     +E V+    N+ K   
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-EIDDLSSSMESVSKSKANLEKICR 1251

Query: 679  ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK----VTRLTQ 734
             LE  L E    N  +Q++  +L+  ++ L+        EA +L  +LE+    V++L++
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQT-------EAGELSRQLEEKESIVSQLSR 1304

Query: 735  LEQS------ALQAELEKERQALKNALGKA-------------QFSEEKE---------- 765
             +Q+       L+ +LE+E +A KNAL  A             Q+ EE+E          
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKA-KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363

Query: 766  QENSELHAKLKHLQDDNNLLKQQLKDFQNHL-NHVVDGLVRPEEVAARVDELRRKLKLGT 824
            + NSE+       + D     ++L++ +  L   + D   + E V A+   L +  +   
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423

Query: 825  GE----MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR-ERKLQEEMALQQE-- 877
            GE    M     ++ L  +L   Q+ F ++LA  K + +E+Q   E  L+E  +L  E  
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 1483

Query: 878  KLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN--EIHYLQENLKSMEEIQGLTDL 935
            KL    EE     E       N ++   +   Q  EN   IH L+++ K +E  +    L
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543

Query: 936  QLQEAD----EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKK----AVATSD 987
             L+EA+     E+ +IL    EL + K   D K  E+    D+E+++LK+     V T  
Sbjct: 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK----DEEIEQLKRNYQRTVETMQ 1599

Query: 988  KLATAELTIAKDQL---KSLHGTVMKI-------NQERAE----------ELQEAERFSR 1027
                AE+    + +   K + G + +I       N++ AE          +L++ +    
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659

Query: 1028 KAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTG----------VGTGANSQVLEI 1077
             A +   DL    A +E   NLL+ + E+ R  +E+T           + +    Q+L  
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHT 1719

Query: 1078 E--KLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAE 1118
            +   L  T ++  T++ +LQ+ ++    D +   E   + I +
Sbjct: 1720 QNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 1762



 Score =  119 bits (298), Expect = 3e-26
 Identities = 163/756 (21%), Positives = 342/756 (45%), Gaps = 85/756 (11%)

Query: 440  EDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA-----IQLKKISEAGKDL- 493
            E +EK ++  Q + ++L  +++   + +L A E   QL +A      ++K+++E  +D  
Sbjct: 873  ELEEKLVTLVQEK-NDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEE 931

Query: 494  -LYKQLSGRLQLV----NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS--- 545
             +  +L+ + + +    ++L+++  DLEL + K ++E    + ++K+L   +  LD    
Sbjct: 932  EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA 991

Query: 546  ------KDPKHSHMKA--QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLE- 596
                  K  + +H +A      +E +++ +NK   +LE +++++ S + +E +   DLE 
Sbjct: 992  KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051

Query: 597  -EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
             ++  EG +   +    DLE     L E L     +  Q Q+   K+ DE+   LQ   +
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS---KVEDEQTLGLQFQKK 1108

Query: 656  VEQERDQLEIVAMDAENMRKELAELESA----LQEQHEVNASLQQTQGDLSAYEAELEAR 711
            +++ + ++E +  + E  R   A+ E       +E  E++  L++  G +++ + EL  +
Sbjct: 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA-GGVTSTQIELNKK 1167

Query: 712  LNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKA-----QFSEEKEQ 766
               R+AE  +L+ +LE+ T    L+  A+ A L K+       LG+      +  ++ E+
Sbjct: 1168 ---REAEFLKLRRDLEEAT----LQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220

Query: 767  ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKL-KLGTG 825
            E SE   ++  L      + +   + +     + D L    E   + +E++R L +L T 
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL---SEARGKNEEIQRSLSELTTQ 1277

Query: 826  EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEM--------ALQQE 877
            +  + + +  L + L + +   S++    +    + +  +R+L+EE         ALQ  
Sbjct: 1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS 1337

Query: 878  KLATG--QEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDL 935
            +      +E++ +  E   E +    K   E    + + E   +Q   + +EE +     
Sbjct: 1338 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQ 1396

Query: 936  QLQEADEEKERILAQLRELEKKKK-----LEDA-----KSQEQVFGLDKELKKLKKAVA- 984
            +LQ+++E+ E + A+   LEK K+     +ED      ++      LDK+ +   K +A 
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456

Query: 985  --TSDKLATAELTIAKDQLKSLHGTVMKIN---QERAEELQEAERFSRKAAQAARDLTRA 1039
              T  + + AEL  +  + +SL   + K+    +E  ++L+  +R ++   Q   DLT  
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 1516

Query: 1040 EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
             AE     + L +  +Q  +E+EK  +        L +E+    +E +  +I R+Q  L 
Sbjct: 1517 IAENGKTIHELEKSRKQ--IELEKADIQ-------LALEEAEAALEHEEAKILRIQLELT 1567

Query: 1100 LTGSDNKGGFENVLEEIAELRREVSYQNDYISSMAD 1135
               S+         EEI +L+R      + + S  D
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603



 Score =  119 bits (298), Expect = 3e-26
 Identities = 230/1089 (21%), Positives = 449/1089 (41%), Gaps = 204/1089 (18%)

Query: 125  VKLEVLNLSYNLIGKIEKLDKLLKLR----------------ELNLSYNKISKIEGIENM 168
            ++L+V   S NL+   E+ D+L+K +                E  ++    +K   +E+ 
Sbjct: 888  LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947

Query: 169  CNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVEN 228
            C+  K      +I+ + + L K  K         NK+ +L +  +L  L + I+ +  E 
Sbjct: 948  CSELK-----KDIDDLELTLAKVEKEKHATE---NKVKNLTE--ELSGLDETIAKLTREK 997

Query: 229  PVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEE 288
              +   H         ++L+ L+ +    +D+  +  + +  ++E+   DLE  + + ++
Sbjct: 998  KALQEAHQ--------QALDDLQAE----EDKVNSLNK-TKSKLEQQVEDLESSLEQEKK 1044

Query: 289  LKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQK 348
            L+    R      N+ KL   LK    L ++S  +L++D    +E LK+K  E    CQ 
Sbjct: 1045 LRVDLER------NKRKLEGDLK----LAQESILDLENDKQQLDERLKKKDFEY---CQL 1091

Query: 349  QYELEQE----LAFYK----IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFAT 400
            Q ++E E    L F K    + A+ E L     E  E ++A        +S Y R +   
Sbjct: 1092 QSKVEDEQTLGLQFQKKIKELQARIEELE----EEIEAERATRAKTEKQRSDYARELEEL 1147

Query: 401  ESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSE 455
             S  ++ A  V   ++E +++   + + LR      T   +       KK + +   L E
Sbjct: 1148 -SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE 1206

Query: 456  LHDEIEKAEQQILRATEEFK--------QLEEAIQLK------------KISEA-GK-DL 493
              D +++ +Q++ +   EFK         +E   + K            ++SEA GK + 
Sbjct: 1207 QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE 1266

Query: 494  LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIA----GKQKEIKDLQIAIDSLDSKDPK 549
            + + LS      ++L+ EA +L  Q+E+++  ++     KQ   +  +     L+ ++  
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326

Query: 550  HSHMKAQKSGKEQQLDIMNKQYQQ-------LESRLDEILSRIAK-----------ETEE 591
             + +           D++ +QY++       L+  L +  S +A+            TEE
Sbjct: 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1386

Query: 592  IKDLEEQLTE-------------GQIAANEALKKDLEGVISGLQ---------------- 622
            +++ +++L +              + A+ E  K+ L+G +  L                 
Sbjct: 1387 LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK 1446

Query: 623  -----EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEV----EQERDQLEIVAMDAENM 673
                 + L   K +  ++Q E      E  +L   L ++    E+  DQLE V  + +N+
Sbjct: 1447 QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL 1506

Query: 674  RKELAELESALQEQ----HEVNASLQQTQ---GDLSAYEAELEARLNLRDA-------EA 719
             +E+A+L   + E     HE+  S +Q +    D+     E EA L   +A       E 
Sbjct: 1507 EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566

Query: 720  NQLKEEL-----EKVTRLTQLE----------QSALQAELEKERQALKNALGKAQFSEEK 764
             Q+K E+     EK   + QL+          QSAL AE+    +A++  L K    +  
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR--LKKKMEGDLN 1624

Query: 765  EQENSELHAK------LKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRR 818
            E E    HA       LKHL+     ++ QLKD Q HL+  + G    +E  A V+    
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRS----VQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680

Query: 819  KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR-ERKLQEEMALQQE 877
             L+    E+          + LA+ +   S    +    ++ + +  ++KL+ ++   Q 
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740

Query: 878  KLATGQEEFRQACERALEARMNFDKRQHEARIQQ-----MENEIHYLQENLKSME-EIQG 931
            ++     + R A E+A +A  +      E + +Q     +E     L++ +K ++  +  
Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1800

Query: 932  LTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 991
               L L+   ++ +++  ++RELE + + E  K+ E V GL K  +++K+    S++   
Sbjct: 1801 AEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRK 1860

Query: 992  AELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQ---N 1048
              L + +D +  L   V    ++  E  ++A     K  +A  +L  AE   ++ +   N
Sbjct: 1861 NVLRL-QDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVN 1919

Query: 1049 LLRQKGEQF 1057
             LR K   F
Sbjct: 1920 KLRAKTRDF 1928



 Score =  108 bits (269), Expect = 8e-23
 Identities = 130/608 (21%), Positives = 261/608 (42%), Gaps = 63/608 (10%)

Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
            C++      E +  + E  +Q   SK   E  +W    +  + +  EEL      L Q  
Sbjct: 1341 CDLLREQYEEEQEGKAE--LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398

Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
            +  E +VE ++      ++ K  + G VE LM ++E        ++K  ++ + ++ E  
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK 1458

Query: 1421 IEC------IEKTLLKRRS---ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
             +C      +E +L + RS   EL +      EA  +L   K + KN  ++  D    + 
Sbjct: 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIA 1518

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAK-DLEQHKIKQ-----EEILKEINKI 1525
            +      ELE+  ++  + L KAD QL   +A+A  + E+ KI +      ++  EI++ 
Sbjct: 1519 ENGKTIHELEKSRKQ--IELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRK 1576

Query: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1585
            +A KD + + L +  ++  E +Q    D E+  RNE   L+                +K+
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQSAL-DAEVRSRNEAIRLK----------------KKM 1619

Query: 1586 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV 1645
            +  +   + +++  +RQ     + L  +QG +   +  L +ALR G+ ++ E+   +   
Sbjct: 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR-GQEDLKEQLAIVERR 1678

Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ-MSKHKTELKNILDM 1704
             +LL+    +  EL   + + +    L +QE+    E +Q++  Q  S   T+ K   D+
Sbjct: 1679 ANLLQA---EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDL 1735

Query: 1705 LQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERD 1764
            +QL++      +   D R +E EK + A+ +  +  E L++  Q     +E  K+ LE+ 
Sbjct: 1736 MQLQSEVEDASR---DARNAE-EKAKKAITDAAMMAEELKK-EQDTSAHLERMKKNLEQT 1790

Query: 1765 KREIERMTAESRAL-----QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819
             ++++    E+  L     +  ++ L     +L+ + +  +KK  ++ + L   E   K 
Sbjct: 1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE 1850

Query: 1820 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1879
                 E+   NV +LQ  +D+L     S         +Q           Q EL   ++ 
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910

Query: 1880 LNLAKQDL 1887
             ++A+  +
Sbjct: 1911 ADIAESQV 1918



 Score =  102 bits (253), Expect = 6e-21
 Identities = 123/617 (19%), Positives = 260/617 (42%), Gaps = 57/617 (9%)

Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
            S + + E+   K+  ++ K E+ +  A+ + L+  +  L +EK DLQ             
Sbjct: 843  SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902

Query: 1794 -EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
             E+CD   K   Q +  +    E ++ E+    +L    RKL+ E  +L +D   L   +
Sbjct: 903  EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962

Query: 1853 SAMQQQLQEKREAVNSLQEELANVQDHL-NLAKQDLLHTTKHQDVLLSEQTRLQK--DIS 1909
            + ++++       V +L EEL+ + + +  L ++       HQ  L   Q    K   ++
Sbjct: 963  AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022

Query: 1910 EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV 1969
            +  ++ E   ++ E+  +Q + L+ ++E NK KL     + Q    + E+++ +L+    
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082

Query: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSE 2029
                +  QL+ ++ D+++   Q   K+   + R+  L+EE    E+   T ++T++Q S+
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE---IEAERATRAKTEKQRSD 1139

Query: 2030 REQQL------VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQVASLKEALKI 2082
              ++L      +E++G + + Q E +  R A+F  LR        + E  VA+L++    
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199

Query: 2083 QRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMA- 2141
              ++L + +   ++    ++KE +  +L   D       + K    ++     L+ Q++ 
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259

Query: 2142 ---NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG 2198
                 ++++R   E++     L++E   E+   L+     + +L    +A  ++ E L+ 
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQTEA-GELSRQLEEKESIVSQLSRSKQAFTQQTEELKR 1318

Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
            +LE               E K   +  H +        L  +    E   KA+L+  +SK
Sbjct: 1319 QLEE--------------ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364

Query: 2259 -QAEV----------LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESS 2307
              +EV           I+   + E     L +++    E V + +A  AS     Q    
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424

Query: 2308 LTEDSQLGQNQEKNASA 2324
              ED  +   +  + +A
Sbjct: 1425 EVEDLMVDVERANSLAA 1441



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 130/683 (19%), Positives = 286/683 (41%), Gaps = 80/683 (11%)

Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRV 1723
            +E + ++  +K+E +K ++ L    +  +K K EL+  L  L  E ++LQ       + +
Sbjct: 844  AETEKEMATMKEEFQKTKDELA---KSEAKRK-ELEEKLVTLVQEKNDLQLQVQAESENL 899

Query: 1724 SELEKTQVAVLEEKLELE-NLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV 1782
             + E+    +++ K +LE  +++++++ + E               E + AE        
Sbjct: 900  LDAEERCDQLIKAKFQLEAKIKEVTERAEDE---------------EEINAE-------- 936

Query: 1783 ECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN 1842
              L+ +K  L+++C   +K +   +  LA  E+     ++ ++ L   +  L + + +L 
Sbjct: 937  --LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT 994

Query: 1843 RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT 1902
            R+K +L          LQ + + VNSL +  + ++  +   +  L    K +  L   + 
Sbjct: 995  REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKR 1054

Query: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQ-------VLQNEIEENKLKLVQQEMMFQRLQK 1955
            +L+ D+        D + +++   ++L+        LQ+++E+ +   +Q +   + LQ 
Sbjct: 1055 KLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114

Query: 1956 ERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCES 2015
              E  E ++E  + T    + + EK+ +D   +L++ LS+ L     V + Q E    + 
Sbjct: 1115 RIEELEEEIEAERAT----RAKTEKQRSDYARELEE-LSERLEEAGGVTSTQIELN--KK 1167

Query: 2016 LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVAS 2075
             E    + +R L   E+  ++    + AL+K+     A+     +     ++K EK+   
Sbjct: 1168 REAEFLKLRRDL---EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE--- 1221

Query: 2076 LKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE---LVAQDNHERARRLMKEL----NQ 2128
             K   K++   L  ++    +  + ++K   T+E     A+  +E  +R + EL    ++
Sbjct: 1222 -KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280

Query: 2129 MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPA---D 2185
            +Q E  EL +Q+  ++ +  +      A      E+K ++    K  N     L +   D
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD 1340

Query: 2186 LEAILER-NENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDE-HWRGEALREKLRH 2243
             + + E+  E  EG+ E  +           +  K     +   +E     + L ++L+ 
Sbjct: 1341 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1400

Query: 2244 REDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSAS------ 2297
             E++++A    C S     L K K++ +G +  L   V+    L  +      +      
Sbjct: 1401 SEEQVEAVNAKCAS-----LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455

Query: 2298 ------SPSLSQLESSLTEDSQL 2314
                    S ++LE+SL E   L
Sbjct: 1456 EWKTKCEESQAELEASLKESRSL 1478



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 111/543 (20%), Positives = 221/543 (40%), Gaps = 102/543 (18%)

Query: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
            K A+T++ +A  +E  +  +  L K E   ++L+++L  L ++K    ND+     QLQ 
Sbjct: 842  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEK----NDL-----QLQV 892

Query: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
            + E+ N L  E                   +  D L+  + +L+  I E   R ED ++ 
Sbjct: 893  QAESENLLDAE-------------------ERCDQLIKAKFQLEAKIKEVTERAEDEEEI 933

Query: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
                  + + L++E  E K  +   E+   +++KE+ + E+K+               K 
Sbjct: 934  NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---------------KN 978

Query: 1982 LTDQKSKLDQVLSKVL--------AAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQ 2033
            LT++ S LD+ ++K+         A ++ +  LQ EE    SL KT S+ ++Q+ + E  
Sbjct: 979  LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038

Query: 2034 LVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLE 2093
            L ++    + L++    +  D  L +   L                L+  + QL++ L +
Sbjct: 1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILD---------------LENDKQQLDERLKK 1083

Query: 2094 QKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEI 2153
            +  E   +Q ++       +D      +  K++ ++Q    EL++           ++E 
Sbjct: 1084 KDFEYCQLQSKV-------EDEQTLGLQFQKKIKELQARIEELEE-----------EIEA 1125

Query: 2154 SDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNE 2213
              A R    + + +    L+ L++ L E        +E N+  E E   L+ +L     +
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ 1185

Query: 2214 -----GPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKR 2268
                     +K   S   + ++    + +++KL   +   K ++   +S   E + K K 
Sbjct: 1186 HEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD-LSSSMESVSKSKA 1244

Query: 2269 QTEGTLHSLRRQVD-----------ALGELVTSTSADSASSPSLS-QLESSLTEDSQLGQ 2316
              E    +L  Q+            +L EL T  S     +  LS QLE   +  SQL +
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 1304

Query: 2317 NQE 2319
            +++
Sbjct: 1305 SKQ 1307



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 39/162 (24%), Positives = 79/162 (48%), Gaps = 15/162 (9%)

Query: 1320 NLENEVSRLEDIMQH-----LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE 1374
            NLE  V  L+  +       LK  K++ + +    R+ E E+E       + ++  +  E
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845

Query: 1375 CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE-KSLKHHEDIVDEIECIEKTLLKR-R 1432
              V+EL  T Q  + +K+ +   ++ L+ +L+++ KS K   +  DE      T  ++ +
Sbjct: 1846 RRVKEL--TYQSEEDRKNVL--RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQ 1901

Query: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTE 1474
             EL EA+     AES+++  + KT++    FT ++  + ++E
Sbjct: 1902 HELEEAEERADIAESQVNKLRAKTRD----FTSSRMVVHESE 1939


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  159 bits (402), Expect = 3e-38
 Identities = 221/1097 (20%), Positives = 468/1097 (42%), Gaps = 161/1097 (14%)

Query: 1321 LENEVSRL----EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            LE +++ L    +D +  LK+   E         + E+ + EL   ++  +Q    LE +
Sbjct: 585  LEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQK 644

Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
            V EL   +++  ++KD  D  +E LM ++                    K L + +  L 
Sbjct: 645  VNELTGGLEETLKEKDQNDQKLEKLMVQM--------------------KVLSEDKEVLS 684

Query: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
               + L E  ++LS  K++    +E F   K  ++  E    +LE++ Q     L+  +Q
Sbjct: 685  AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEH-ITQLEKKLQ-----LMVEEQ 738

Query: 1497 QLRSLQADAKDLEQHKIKQE--EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD- 1553
               +   + + +++  +K +    LKE+   V+ +DS+ + +    + + E L K+ ++ 
Sbjct: 739  DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVS-EDSEEKDVVNVLQAVGESLAKINEEK 797

Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
              +A + ++  L++ KE + L +    + E+LKS +   +QE  +L ++L   + E   L
Sbjct: 798  CNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEAL 857

Query: 1614 QGSMVQAKADLQEALRLGET-------EVTEKCN----HIREVKSLLEELSFQKGELNV- 1661
            Q  +++ K +  E  RL          EV++ C+    H  + K  ++E    K  L   
Sbjct: 858  QSDLLEMK-NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK 916

Query: 1662 QISERKTQLTLIK-----------------QEIEKEEENLQVVLRQMS-----------K 1693
            ++ +R+ +L L+K                 +E+E++ ENL+   ++             K
Sbjct: 917  ELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVK 976

Query: 1694 HKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGE 1753
             K EL +     Q    EL+ L+ + DQ    L  +   +++     +NL    ++Q  +
Sbjct: 977  AKKELDSSRKETQTVKEELESLRSEKDQ----LSASMRDLIQGAESYKNLLLEYEKQSEQ 1032

Query: 1754 IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL-------QEKCDIWEKKLAQT 1806
            ++ +K+     +  IE +T + R      E ++ + EDL       Q    + E ++ + 
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092

Query: 1807 KRVLAAAEENSKMEQ--------------SNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
            +R  A  ++  + E+              + LE+L++ ++K +++L +  ++   +  D 
Sbjct: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152

Query: 1853 ---SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDIS 1909
               + M  ++ +    +  L ++L N  + +   +Q++    + Q+ L  E T LQ  + 
Sbjct: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212

Query: 1910 EWANRFEDCQKEEETKQQQLQV-LQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
            ++        +E+ TK +QL V  + E+ ++K       ++   L+ E E+ + ++E  K
Sbjct: 1213 QY--------EEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYK 1264

Query: 1969 VTLKE---QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKR 2025
            + L E   ++H++ + L     +  + LS   A ++RV  LQEE R  ++ + T++    
Sbjct: 1265 IQLAEITSEKHKIHEHLKTSAEQHQRTLS---AYQQRVTALQEECRAAKAEQATVTSEFE 1321

Query: 2026 QLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRS 2085
                R   ++++       Q E +  +            ER+  E  +  LK  L+  ++
Sbjct: 1322 SYKVRVHNVLKQQKNKSMSQAETEGAK-----------QEREHLEMLIDQLKIKLQDSQN 1370

Query: 2086 QLEKNLLE----QKQENSCIQKEMATIELVAQDNHERARRL---MKELNQMQYEYTELKK 2138
             L+ N+ E    Q + ++ +++    ++       E   +L     E   M+ E+T+   
Sbjct: 1371 NLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVS 1430

Query: 2139 QMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPEL-----PADLEAILERN 2193
            Q+ +Q ++ R      D +R L+ E +  + T  + L++   +L          + +   
Sbjct: 1431 QLTSQNEVLRNSFR--DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ 1488

Query: 2194 ENLEGELESLKENLPF------TMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
            ++L+   E    +LP       T  EG   E  +   V     +   ++L + L   E +
Sbjct: 1489 QSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTY--TQSLEQLLNSPETK 1546

Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESS 2307
            L+  L H    + E++ K        L S  +  D L  L+  T A +A    + Q++  
Sbjct: 1547 LEPPLWHAEFTKEELVQK--------LSSTTKSADHLNGLLRETEATNAI--LMEQIKLL 1596

Query: 2308 LTEDSQLGQNQEKNASA 2324
             +E  +L +NQE+  SA
Sbjct: 1597 KSEIRRLERNQEREKSA 1613



 Score =  153 bits (386), Expect = 2e-36
 Identities = 235/1093 (21%), Positives = 487/1093 (44%), Gaps = 136/1093 (12%)

Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLE----CEVE 1378
            E+  L++  ++L+ +K+E      S R+  + ++ EL  +   + QE +S++     +V 
Sbjct: 458  EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 517

Query: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS----E 1434
            EL + ++    +KD +   V  L  E E    L   +++V E+E   K L ++       
Sbjct: 518  ELQQKLRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIKNLQEKNGVYLLS 574

Query: 1435 LREADRLLAEAESELSCTKE-------KTKNAVEKFTDAKRSLLQTESDAEELERRAQET 1487
            L + D +L E E +++   E       K KN+ E+  +  +   + E    EL ++ ++T
Sbjct: 575  LSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQT 634

Query: 1488 AVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL 1547
                 + +Q++  L    ++  + K + ++ L+++   +     D + LS + + L EE 
Sbjct: 635  IQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN 694

Query: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELE-KLKSQVTSQQQEMAVLDRQLGHK 1606
             KL    E  + + D  + + ++ +V+L+    +LE KL+  V  Q     +L+ +   K
Sbjct: 695  NKLSS--EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQK 752

Query: 1607 ---KEELHLL---QGSMVQAKADLQEALR----LGETEV---TEKCN----HIREVKSLL 1649
               K +L+      GS V   ++ ++ +     +GE+      EKCN       +V  L 
Sbjct: 753  LFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELE 812

Query: 1650 EELSFQKGELNVQISERKTQLTLIKQE---IEKEEENLQVVLRQMSKHKTELKNILDMLQ 1706
            +E+   + E  VQ  E K+ L   +QE   + KE E +Q     +     E+KN  +  +
Sbjct: 813  KEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTR 872

Query: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKL---ELENLQQISQQQKGEIEWQKQLLER 1763
            LEN   Q L +Q ++      K+++   +EK    E ENL+ + +Q+  E+  ++  L  
Sbjct: 873  LEN---QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK--ELRDRRAELIL 927

Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
             K  + +  +      S V+ L ++ E+L+++C   E+K+ + K V   A++     +  
Sbjct: 928  LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987

Query: 1824 LEKLELNVRKLQQELDQLN---RDKL-------SLHNDISAMQQQLQEKREAVNSLQEEL 1873
             + ++  +  L+ E DQL+   RD +       +L  +     +QL  ++E  N+ +  +
Sbjct: 988  TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047

Query: 1874 ANVQ----------DHLNLAKQDLL---HTTKHQDVLLSEQ---TRLQKDISEWANRFED 1917
             ++           + +N   +DLL    T +    LL  Q    +  K + +     E 
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEK 1107

Query: 1918 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE-----RESEESKLETSKVTLK 1972
             QKE++ K+    V  NE+EE +++L +++   Q+  +E     ++++++ L   ++   
Sbjct: 1108 LQKEQKIKEHATTV--NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADY 1165

Query: 1973 EQ-QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSERE 2031
            E+   +L ++LT++ +K++ +  ++   +++  TLQEE     SL+ ++ Q + + ++ +
Sbjct: 1166 ERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEE---ITSLQSSVQQYEEKNTKIK 1222

Query: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK-------------- 2077
            Q LV+   E LA  K+A++   D  +L+     E + +++QV   K              
Sbjct: 1223 QLLVKTKKE-LADSKQAET---DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIH 1278

Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQK-------EMATIELVAQDNHERARRLMKELNQMQ 2130
            E LK    Q ++ L   +Q  + +Q+       E AT+    +    R   ++K+     
Sbjct: 1279 EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKS 1338

Query: 2131 YEYTELKKQMANQKDLE----RRQMEISDAMRTLKSEVKD------EIRTSLKNLNQFLP 2180
                E +     ++ LE    + ++++ D+   L+  V +      E  T L+  N+ L 
Sbjct: 1339 MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ 1398

Query: 2181 ELPADLEAILER-----NENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRG- 2234
            E  +    + E+     +EN+  + E  +     T               H+ +EH +  
Sbjct: 1399 ETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV 1458

Query: 2235 EALREKLRHREDRLKAQLRH-------CMSKQAEVLIKGKRQTEGTLHSLRRQVDALGEL 2287
            E L+++L   E +L  QL++         S+Q+   ++ +R T+  L  +       GE 
Sbjct: 1459 ETLQQQLSKMEAQL-FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEG 1517

Query: 2288 VTSTSADSASSPS 2300
            + +T  +S SS S
Sbjct: 1518 METTDTESVSSAS 1530



 Score =  135 bits (341), Expect = 4e-31
 Identities = 234/1049 (22%), Positives = 461/1049 (43%), Gaps = 164/1049 (15%)

Query: 1329 EDIMQHLKSKKREERWMRASKRQSEKEMEELH----------------HNIDDLLQEKKS 1372
            ED+++  K +    +  ++   + EKE+EEL                   +D LL EK  
Sbjct: 28   EDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAE 87

Query: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
             E +   L +   K +Q+       VE  +T++     E+E+S   H + V EIE ++  
Sbjct: 88   TEQQCLSLKKENIKMKQE-------VEDSVTKMGDAHKELEQS---HINYVKEIENLKNE 137

Query: 1428 LLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET 1487
            L+  RS+        +E ++ L    E+  N   + ++  +    +E + ++L+   ++ 
Sbjct: 138  LMAVRSKY-------SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI 190

Query: 1488 AVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL 1547
                   ++Q+  LQ   K L+    +++E + ++  I+ A    +Q   K    L EEL
Sbjct: 191  RPGF---EEQILYLQ---KQLDATTDEKKETVTQLQNIIEANSQHYQ---KNINSLQEEL 241

Query: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607
             +L K I   E  E     ++ + E   +   AE+ KL     +  ++    ++ +  K 
Sbjct: 242  LQL-KAIHQEEVKE-----LMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKY 295

Query: 1608 E-ELHLLQGSMVQAKADLQ------EALRLGETEVTEKCNHIRE-VKSLLEELSFQKGEL 1659
            E EL  L+ +   A  D Q      +     E  V EK  H+ + +K L  + S  K E+
Sbjct: 296  ECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEV 355

Query: 1660 NVQISERKTQLTL----IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE------- 1708
               ++  K +L +    IK E   E E+L+  + ++   K E   +++ L+ E       
Sbjct: 356  TY-MNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414

Query: 1709 --------NHELQGLKLQHDQRVSELEKTQVAVLE-EKLEL-----------ENLQQISQ 1748
                    N E+Q LK QH + +SEL +T ++  E EKL L           ENLQQ  Q
Sbjct: 415  FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQ 474

Query: 1749 QQKGEIEWQKQLLERDKREIERMTAE-SRALQSCVECLSKEKEDLQEKC-DIWEKKLAQT 1806
            +     E  ++++E  + E+     + S+  +S  +  + +  +LQ+K    + +K A  
Sbjct: 475  EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALL 534

Query: 1807 KRVLAAAEENSKM--EQSNLEKLELNVRKLQQE-----LDQLNRDKL--SLHNDISAMQQ 1857
            + V     EN K+  +Q  + +LE  ++ LQ++     L    RD +   L   I+++ +
Sbjct: 535  ETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTE 594

Query: 1858 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1917
            +  +    + +  EE+ N        ++ +L   K  +  +   + L++ ++E     E+
Sbjct: 595  EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEE 654

Query: 1918 CQKEEETKQQQLQVL---------QNEIEENKLKLVQQE---MMFQRLQKERESEESKLE 1965
              KE++   Q+L+ L           E+   ++K + +E   +  ++ Q  R+ E    +
Sbjct: 655  TLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ 714

Query: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKR 2025
               V LKE   QLEK+L     + D  L+K+L   E+V+ L  + +    L++  S+   
Sbjct: 715  KEDVILKEHITQLEKKLQLMVEEQDN-LNKLL-ENEQVQKLFVKTQLYGFLKEMGSEVSE 772

Query: 2026 QLSERE-QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR 2084
               E++   +++  GE LA   + +  + + +  R++ + E    EK++  L+E   +Q 
Sbjct: 773  DSEEKDVVNVLQAVGESLA---KINEEKCNLAFQRDEKVLE---LEKEIKCLQEESVVQC 826

Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQK 2144
             +L+  L + +QE   ++KE+  I+               E   +Q +  E+K   AN+K
Sbjct: 827  EELKSLLRDYEQEKVLLRKELEEIQ--------------SEKEALQSDLLEMKN--ANEK 870

Query: 2145 DLERRQ---MEISDAMRTL-KSEVKDEIRTSLKNLNQFLPELPADLEAILERNE--NLEG 2198
                 Q   +++ +  +T  KSE+ +E          F+ E   +L+ +LE+ E  +   
Sbjct: 871  TRLENQNLLIQVEEVSQTCSKSEIHNEKEKC------FIKE-HENLKPLLEQKELRDRRA 923

Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
            EL  LK++L     + P  +    S V  ++E  + E L ++ + +E+++  +++    K
Sbjct: 924  ELILLKDSLA----KSPSVKNDPLSSVKELEE--KIENLEKECKEKEEKIN-KIKLVAVK 976

Query: 2259 QAEVLIKGKRQTEGT---LHSLRRQVDAL 2284
              + L   +++T+     L SLR + D L
Sbjct: 977  AKKELDSSRKETQTVKEELESLRSEKDQL 1005



 Score =  107 bits (268), Expect = 1e-22
 Identities = 152/707 (21%), Positives = 297/707 (42%), Gaps = 93/707 (13%)

Query: 1320 NLENEVSRLEDIMQHLK-----------SKKREERWMRASKRQSEKEMEELHHNIDDLLQ 1368
            NLE E    E+ +  +K           S ++E + ++        E ++L  ++ DL+Q
Sbjct: 955  NLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014

Query: 1369 ---EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDE 1420
                 K+L  E E+    +   +++ +  +  +E L  +L     + E     +ED++  
Sbjct: 1015 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLAR 1074

Query: 1421 IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEEL 1480
            IE ++        ++ E  R  A  + EL   K + +  +++          T ++ EEL
Sbjct: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHAT-------TVNELEEL 1127

Query: 1481 ERRAQETAVNLVKADQQLRSLQADAKD---LEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
            + + Q+    L K  Q+L  ++ DA+    +       E ++KE+N+ +  K++  + L 
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187

Query: 1538 K-------KKEKLTEELQKLQKDIEMAERNEDHHLQVL-KESEVLLQAKRAELE------ 1583
            +       K+E L EE+  LQ  ++  E       Q+L K  + L  +K+AE +      
Sbjct: 1188 QEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247

Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT---EKCN 1640
             LK ++ + QQ++ V   QL     E H +   +  +    Q  L   +  VT   E+C 
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307

Query: 1641 HIR-EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIE---KEEENLQVVLRQMSKHKT 1696
              + E  ++  E    K  ++  + ++K + ++ + E E   +E E+L++++ Q+   K 
Sbjct: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNK-SMSQAETEGAKQEREHLEMLIDQL---KI 1363

Query: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSELEK------TQVAVLEEKL---ELENLQQIS 1747
            +L++  + LQ+   ELQ L+ +HD  +    K      ++ A L EKL   + EN+   S
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423

Query: 1748 Q--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQ 1805
            +  Q   ++  Q ++L    R+  R   E            K  E LQ++    E +L Q
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHR---------KTVETLQQQLSKMEAQLFQ 1474

Query: 1806 TKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK-RE 1864
             K      E  ++   S+ + L+ N+R    E    +   L +H       + ++    E
Sbjct: 1475 LKN-----EPTTRSPVSSQQSLK-NLR----ERRNTDLPLLDMHTVTREEGEGMETTDTE 1524

Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
            +V+S      +++  LN  +  L     H +    E  +     ++ A+      +E E 
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEA 1584

Query: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
                     N I   ++KL++ E+      +ERE   + LE  K  L
Sbjct: 1585 T--------NAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL 1623



 Score =  103 bits (258), Expect = 2e-21
 Identities = 203/1004 (20%), Positives = 426/1004 (42%), Gaps = 131/1004 (13%)

Query: 83   ITEALIKKLTKQDNLA------LIKSLNLSLSKDGGKKFK-YIENLEKCVKLEVLNLSYN 135
            +  A +K L +++N        L + L + LS+      K +I  LEK ++L        
Sbjct: 682  VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL-------- 733

Query: 136  LIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSL 195
            ++ + + L+KLL+  ++   + K      ++ M +    +    ++ ++   +G+ L  +
Sbjct: 734  MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793

Query: 196  RV--LNLKGNKISSLQDISK-LKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEG 252
                 NL   +   + ++ K +K LQ+  S++  E     L  Y Q  +   + LE ++ 
Sbjct: 794  NEEKCNLAFQRDEKVLELEKEIKCLQEE-SVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852

Query: 253  QPVTTQ----DRQEAFERFSLE------EVERLERDLEKKMIETEELKS--KQTRFLEEI 300
            +    Q    + + A E+  LE      +VE + +   K  I  E+ K   K+   L+ +
Sbjct: 853  EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPL 912

Query: 301  KNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
              Q +L +  + E +L K S  +   +K+D  +  + L++K   L + C+++ E   ++ 
Sbjct: 913  LEQKEL-RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971

Query: 358  FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKME 417
               + AK E      S   E     +E   +     K  + A+   +I  A++ +   +E
Sbjct: 972  LVAVKAKKE----LDSSRKETQTVKEELESLRSE--KDQLSASMRDLIQGAESYKNLLLE 1025

Query: 418  PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
             ++Q     +        + ++ED  +++  +  +   ++ + E    +I       K L
Sbjct: 1026 YEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL 1085

Query: 478  EEAIQLKKISEAGKDLLYKQLSG-RLQLVNKLRQEAL------DLELQMEKQKQEIAGKQ 530
            E  +Q+ ++  A K ++ K+L   +LQ   K+++ A       +L++Q++K+K+++   Q
Sbjct: 1086 E--VQILEVQRA-KAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL---Q 1139

Query: 531  KEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
            K +++L++       KD              QQ  +MN +    E  + E+  ++  +  
Sbjct: 1140 KTMQELELV-----KKDA-------------QQTTLMNMEIADYERLMKELNQKLTNKNN 1181

Query: 591  EIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLL 650
            +I+DLE+++ + Q    E L++++  + S +Q+Y               ++L D K+   
Sbjct: 1182 KIEDLEQEI-KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240

Query: 651  QRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE-VNASLQQTQGDLSAYEAELE 709
              L      + +LE      E  + +LAE+ S   + HE +  S +Q Q  LSAY+  + 
Sbjct: 1241 DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT 1300

Query: 710  ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENS 769
            A               L++  R  + EQ+ + +E E  +  + N L + +     + E  
Sbjct: 1301 A---------------LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETE 1345

Query: 770  ELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL---------------VRPEEVAARVD 814
                + +HL+   + LK +L+D QN+L   V  L                  +E  ++  
Sbjct: 1346 GAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405

Query: 815  ELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEE--- 871
            ELR KL       +I S + ++    ++  +  S++ ++++  R+  + + R LQEE   
Sbjct: 1406 ELREKL------CSIQSENMMM---KSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456

Query: 872  --MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEI 929
                LQQ+      + F+   E    + ++  +     R ++   ++  L  +  + EE 
Sbjct: 1457 TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLR-ERRNTDLPLLDMHTVTREEG 1515

Query: 930  QGL--TDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
            +G+  TD +   +     + L QL     + KLE      + F  ++ ++KL     ++D
Sbjct: 1516 EGMETTDTESVSSASTYTQSLEQLLN-SPETKLEPPLWHAE-FTKEELVQKLSSTTKSAD 1573

Query: 988  KL------ATAELTIAKDQLKSLHGTVMKI--NQERAEELQEAE 1023
             L        A   I  +Q+K L   + ++  NQER +     E
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLE 1617



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 162/734 (22%), Positives = 314/734 (42%), Gaps = 107/734 (14%)

Query: 431  GHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAG 490
            G + L+T  ++   K +  Q  L      I+KA+    R TE  K++EE ++ K ++E  
Sbjct: 18   GKSKLETLPKEDLIKFAKKQMML------IQKAKS---RCTELEKEIEE-LRSKPVTEGT 67

Query: 491  KDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
             D++ K L+ RL        +AL LE + E ++Q ++ K++ IK  Q   DS+      H
Sbjct: 68   GDII-KALTERL--------DALLLE-KAETEQQCLSLKKENIKMKQEVEDSVTKMGDAH 117

Query: 551  SHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEA- 609
              ++       ++++ +  +   + S+  E  + + K+ EE  + + +L+E     N + 
Sbjct: 118  KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSE 177

Query: 610  -----LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
                 L++++E +  G +E +  ++ Q     +E    + E  T LQ + E   +  Q  
Sbjct: 178  DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDE----KKETVTQLQNIIEANSQHYQKN 233

Query: 665  IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE 724
            I      ++++EL +L++  QE+             +     ++EA     +AE N+L E
Sbjct: 234  I-----NSLQEELLQLKAIHQEE-------------VKELMCQIEASAKEHEAEINKLNE 275

Query: 725  ELEKVTRLTQLEQSALQ----AELEKERQALKNALGKAQFSEEKEQENS----ELHAKLK 776
              E + +  +  +  +Q     ELE  R+A  NA    Q      QEN+     ++ K+K
Sbjct: 276  LKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK 335

Query: 777  HLQDDNNLLKQQ---LKDFQNHLNHV-----VDGLVRPEEVAARVDELRRKL-KLGTGEM 827
            HL+D    L+ Q   LKD   ++N++     +D     +E     ++L  K+ +L   + 
Sbjct: 336  HLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKE 395

Query: 828  NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE-- 885
                  + L   LA L KQF   +   +  R+   ++E+  +E   L +  L+  ++E  
Sbjct: 396  EQGCVIEKLKSELAGLNKQFCYTV--EQHNREVQSLKEQHQKEISELNETFLSDSEKEKL 453

Query: 886  --------FRQACE----RALEARMNFDKRQHEARIQQME--NEIHYLQENLKSMEEIQG 931
                     ++ CE       EA +N++  +    I Q E       + +  +SM++ Q 
Sbjct: 454  TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513

Query: 932  LTDLQLQE----ADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
                +LQ+    A  EK+ +L  +  L+ +   E   SQ++   L  EL+   K +   +
Sbjct: 514  SDVHELQQKLRTAFTEKDALLETVNRLQGEN--EKLLSQQE---LVPELENTIKNLQEKN 568

Query: 988  KLATAELTIAKDQLKSLHGTVMKINQERAEEL-------QEAERFSRKAAQAARDLTRAE 1040
             +    L+     LK L G +  + +E+ + +       +E + F +K  +  R +    
Sbjct: 569  GVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELG 628

Query: 1041 AEIE---LLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE-----IEKLNETMERQRTEIA 1092
             ++E      + L QK  +    +E+T      N Q LE     ++ L+E  E    E+ 
Sbjct: 629  KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVK 688

Query: 1093 RLQNVLDLTGSDNK 1106
             L    +   S+ K
Sbjct: 689  SLYEENNKLSSEKK 702



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 172/915 (18%), Positives = 375/915 (40%), Gaps = 152/915 (16%)

Query: 268  SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
            +L+E ++ ++ LEK M++ + L   +     E+K+  + N  L  E   +KQ   +L+  
Sbjct: 655  TLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE---KKQLSRDLEVF 711

Query: 328  LNTKNE-LLKQKTIELTRACQKQYELEQEL-------AFYKIDAKFEPLNYYPSEYAEID 379
            L+ K + +LK+   +L +  Q   E +  L          K+  K +   +     +E+ 
Sbjct: 712  LSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVS 771

Query: 380  KAPDESPY------IGKSRYKRN------MFATESYIIDSAQAVQIKKMEPDEQLRNDHM 427
            +  +E         +G+S  K N       F  +  +++  + ++  + E   Q      
Sbjct: 772  EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE--- 828

Query: 428  NLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKIS 487
                   L + L D E++    +  L E+  E E  +  +L    E K   E  +L+   
Sbjct: 829  -------LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLL----EMKNANEKTRLE--- 874

Query: 488  EAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKD 547
               ++LL +        V ++ Q     E+  EK+K  I    KE ++L+  ++  + +D
Sbjct: 875  --NQNLLIQ--------VEEVSQTCSKSEIHNEKEKCFI----KEHENLKPLLEQKELRD 920

Query: 548  PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
             + + +   K    +   + N       S + E+  +I    +E K+ EE++ + ++ A 
Sbjct: 921  -RRAELILLKDSLAKSPSVKNDPL----SSVKELEEKIENLEKECKEKEEKINKIKLVAV 975

Query: 608  EALKKDLEG---VISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
            +A KK+L+        ++E L +++ +  Q     R L    E+    L E E++ +QL+
Sbjct: 976  KA-KKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034

Query: 665  IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNL---------- 714
            +    A N    + +L   L+       ++     DL A    L++   L          
Sbjct: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094

Query: 715  ------RDAEANQLKEE---LEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
                  ++ EA +L++E    E  T + +LE+  LQ +L+KE++ L+  + + +  ++  
Sbjct: 1095 AKAMVDKELEAEKLQKEQKIKEHATTVNELEE--LQVQLQKEKKQLQKTMQELELVKKDA 1152

Query: 766  QENS--------------ELHAKL-------KHLQDDNNLLKQQLKDFQNHLNHVVDGLV 804
            Q+ +              EL+ KL       + L+ +  + KQ+ +  Q  +  +   + 
Sbjct: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212

Query: 805  RPEEVAARVDELRRKLKLGTGEM------NIHSPSDVLGKSLADLQK------QFSEILA 852
            + EE   ++ +L  K K    +       ++   + + G+  A  Q+      Q +EI +
Sbjct: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1272

Query: 853  RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARI--- 909
                  +  +    + Q  ++  Q+++   QEE R A  +A +A +  +   ++ R+   
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA--KAEQATVTSEFESYKVRVHNV 1330

Query: 910  -QQMEN------EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL-- 960
             +Q +N      E    ++  + +E +     ++LQ++    +  +++L+ L+ +     
Sbjct: 1331 LKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLL 1390

Query: 961  -EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
                K  ++    + EL++   ++ + + +  +E T    QL S +  +    +++   L
Sbjct: 1391 ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450

Query: 1020 QEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEK 1079
            QE  R + +  Q               Q L + + + F+L+ E T       S V   + 
Sbjct: 1451 QEEHRKTVETLQ---------------QQLSKMEAQLFQLKNEPT-----TRSPVSSQQS 1490

Query: 1080 LNETMERQRTEIARL 1094
            L    ER+ T++  L
Sbjct: 1491 LKNLRERRNTDLPLL 1505



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 234/1062 (22%), Positives = 425/1062 (40%), Gaps = 222/1062 (20%)

Query: 245  RSLESLEGQPVT--TQDRQEAF-ERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIK 301
            + +E L  +PVT  T D  +A  ER     +E+ E + +   ++ E +K KQ       +
Sbjct: 53   KEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQ-------E 105

Query: 302  NQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKT----------IELTRACQKQYE 351
             +D + K       L++     +K   N KNEL+  ++           +L  A   Q E
Sbjct: 106  VEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLE 165

Query: 352  LEQELAFY---------------KIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRN 396
            L ++L F                KI   FE    Y  +  ++D   DE         K  
Sbjct: 166  LSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK--QLDATTDEK--------KET 215

Query: 397  MFATESYIIDSAQAVQ--IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLS 454
            +   ++ I  ++Q  Q  I  ++ +E L+   ++      L  Q+E   K+  A   +L+
Sbjct: 216  VTQLQNIIEANSQHYQKNINSLQ-EELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274

Query: 455  ELHDEI----EKAEQQILRATE-EFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNK-- 507
            EL + +    E +E+ I +  E E + L +A            +L ++ +   Q+VN+  
Sbjct: 275  ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334

Query: 508  ----------------LRQEAL---DLELQMEKQKQEIAGK-QKEIKDLQIAIDSL---- 543
                            L+ E     +L+L++E   Q I  +   E +DL+  I+ L    
Sbjct: 335  KHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAK 394

Query: 544  DSKDPKHSHMKAQKSGKEQQ-----------LDIMNKQYQQLESRLDE-ILSRIAKE--- 588
            + +      +K++ +G  +Q           +  + +Q+Q+  S L+E  LS   KE   
Sbjct: 395  EEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT 454

Query: 589  -TEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIKGQATQ----------- 634
               EI+ L+EQ    Q    EA+   + L  ++  LQ  LG   G+ +Q           
Sbjct: 455  LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQAS 514

Query: 635  ----AQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690
                 Q + R    EK+ LL+ +  ++ E ++L    +  + +  EL      LQE++ V
Sbjct: 515  DVHELQQKLRTAFTEKDALLETVNRLQGENEKL----LSQQELVPELENTIKNLQEKNGV 570

Query: 691  N-ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK--------------VTRLTQL 735
               SL Q    L   E ++ +    +D   N+LK   E+              +  L + 
Sbjct: 571  YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630

Query: 736  EQSALQAELEKERQALKNALGKAQFSEEKEQENSELH-----------------AKLKHL 778
             +  +Q   E E++  +   G  +  +EK+Q + +L                  A++K L
Sbjct: 631  VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690

Query: 779  QDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAAR--VDELRRKLKLGTGEMNIHSPSDVL 836
             ++NN L  + K     L      L + E+V  +  + +L +KL+L   E       D L
Sbjct: 691  YEENNKLSSEKKQLSRDLEVF---LSQKEDVILKEHITQLEKKLQLMVEE------QDNL 741

Query: 837  GKSLAD--LQKQFSEILARSKWERDEAQVRERKLQEEM--ALQQ--EKLATGQEE----F 886
             K L +  +QK F +       +   ++V E   ++++   LQ   E LA   EE     
Sbjct: 742  NKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLA 801

Query: 887  RQACERALEARMNFDKRQHEARIQQMENEI---HYLQENL---KSMEEIQGLTD------ 934
             Q  E+ LE        Q E+ +Q  E +     Y QE +   K +EEIQ   +      
Sbjct: 802  FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL 861

Query: 935  LQLQEADE----EKERILAQLRELEKK-KKLEDAKSQEQVFGLDKE-LKKLKKAVATSDK 988
            L+++ A+E    E + +L Q+ E+ +   K E    +E+ F  + E LK L +     D+
Sbjct: 862  LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR 921

Query: 989  LATAELTIAKDQL--------------KSLHGTVMKINQERAEELQEAERFSRKAAQAAR 1034
               AEL + KD L              K L   +  + +E  E+ ++  +    A +A +
Sbjct: 922  --RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKK 979

Query: 1035 DLTRAEAEIELLQNLLRQ-KGEQFRLEMEKTGVGTGANSQ---VLEIEKLNETMERQRTE 1090
            +L  +  E + ++  L   + E+ +L      +  GA S    +LE EK +E ++ ++  
Sbjct: 980  ELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK-- 1037

Query: 1091 IARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISS 1132
                         +    FE+ +E++    R  + Q + I+S
Sbjct: 1038 -------------ERANNFEHRIEDLTRQLRNSTLQCETINS 1066



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 50/221 (22%), Positives = 102/221 (46%), Gaps = 26/221 (11%)

Query: 906  EARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKS 965
            ++R  ++E EI    E L+S    +G  D+ ++   E  + +L           LE A++
Sbjct: 45   KSRCTELEKEI----EELRSKPVTEGTGDI-IKALTERLDALL-----------LEKAET 88

Query: 966  QEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLH-GTVMKINQERAEELQEAER 1024
            ++Q   L KE  K+K+ V  S      ++  A  +L+  H   V +I   + E +    +
Sbjct: 89   EQQCLSLKKENIKMKQEVEDS----VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144

Query: 1025 FSRKAAQAARDLTRA-EAEIELLQNLLRQKGEQF---RLEMEKTGVGTGANSQVLEIEK- 1079
            +S   A   + L  A   ++EL + L  Q   +    +L+ E   +  G   Q+L ++K 
Sbjct: 145  YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204

Query: 1080 LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELR 1120
            L+ T + ++  + +LQN+++      +    ++ EE+ +L+
Sbjct: 205  LDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLK 245


>gi|50083279 centrosome protein 4 [Homo sapiens]
          Length = 1140

 Score =  159 bits (401), Expect = 4e-38
 Identities = 199/918 (21%), Positives = 398/918 (43%), Gaps = 130/918 (14%)

Query: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
            E E+ RL   +   +S   +   + +  + +EK +  L+  +D L Q  K LE  + EL 
Sbjct: 238  EREIERLSVALDGGRSP--DVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELM 295

Query: 1382 RTVQKRQQQKDFIDGNVESLMTEL----EIEKSLKHHEDIV-----DEIECIEKTLLKRR 1432
             T +    +   +    E L  EL    ++ + L+ H++ V      E+   +K + ++ 
Sbjct: 296  ETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKL 355

Query: 1433 SELREADRLLAEAESELS-CTKEKTKNAVEKF--TDAKRSLLQTESDAEELERRAQETAV 1489
            SE+++ +  +A+ + EL+ C KEK + + E    +D +  + Q E + + L ++ +  AV
Sbjct: 356  SEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAV 415

Query: 1490 N----------------LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDF 1533
                             + + D+    L    K +E+ +   ++ L+ +  I+  +    
Sbjct: 416  TERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCST 475

Query: 1534 QCLSKKKEKL--TEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKR-------AELEK 1584
               +++K  +  T E      +I    R  D   ++L+  E  ++  +       AE +K
Sbjct: 476  SYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDK 535

Query: 1585 LKSQVTSQQQEMAVLDRQ------------LGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
            L       Q+E++ L ++            L  K++EL L     + A+   +EALR   
Sbjct: 536  LSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAE---KEALR--- 589

Query: 1633 TEVTEKCNHIREV--------KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
                EK  HI EV        +  +E L+    +L  +  E K+++ ++K+ IE  E  L
Sbjct: 590  ----EKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL 645

Query: 1685 QVVLRQMSK---HKTELKNILDMLQLENHELQGLKLQHDQRVS----ELE--KTQVAVLE 1735
            +V  ++ S      +  K  ++ L++ N +LQ     +  R+S    ELE  + Q+ +LE
Sbjct: 646  KVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILE 705

Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
            EK++  NL+  SQ +                       E+  ++  +  + KEK+ LQE 
Sbjct: 706  EKIDELNLKMTSQDE-----------------------EAHVMKKTIGVIDKEKDFLQET 742

Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
             D   +K+A  +  LA  E+     +  + + E +V +L++ L   +R+  SL   + A 
Sbjct: 743  VDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAA 802

Query: 1856 QQQLQE---KREAV----NSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI 1908
             ++L E    RE        LQ++LA +         +L    + ++ + S   +   ++
Sbjct: 803  HKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEV 862

Query: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
            S W +     +KE +    + Q+L N  E+ ++K  Q E     ++ E  S    ++T +
Sbjct: 863  SRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLS----IDTER 918

Query: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
              L+E+   LEKE+ +  +      S++ +  + +  L+EE R  E  + T+      L 
Sbjct: 919  RHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR 978

Query: 2029 E-----------REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
            E             QQL  K+ E   +  E ++++++  LL+ Q   ER      V +L+
Sbjct: 979  ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHT----VKNLE 1034

Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQ--KEMATIELVAQDNHERARRLMK-ELNQMQYEYT 2134
              L   R +   + L   ++++ IQ  KE  T+      +  R   +++ ++ Q+Q +Y 
Sbjct: 1035 SLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYD 1094

Query: 2135 ELKKQMANQKDLERRQME 2152
             LK+Q++ ++    R ++
Sbjct: 1095 ALKRQISTERYERERAIQ 1112



 Score =  125 bits (313), Expect = 6e-28
 Identities = 208/1023 (20%), Positives = 429/1023 (41%), Gaps = 183/1023 (17%)

Query: 1353 EKEMEELHHNIDDLLQEKKS-LECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSL 1411
            EK   +L H  + L Q K S ++ E E  +        + +    + E+    LE+ K  
Sbjct: 34   EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93

Query: 1412 KHHEDIVDEIECIEKTLLKRRSELR-----EADRL-LAEAESE-----LSCTKEKTKNAV 1460
            +H +  V E++   K   +  ++L+      A +L L E ES+     +   +EK  +AV
Sbjct: 94   EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153

Query: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVN---------------LVKADQQLRSLQADA 1505
             +    K+  +       +++     + V+               L  AD +++ LQ + 
Sbjct: 154  VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213

Query: 1506 KDLEQHKIKQEEILKEINKIVAAKDSDFQCLS------------------KKKEKLTEEL 1547
              L++     E  +++ +K +  ++ + + LS                  K  EKL   L
Sbjct: 214  HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273

Query: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607
                  ++ A ++ +  ++ L E++  + ++   L     ++  +  E+  L +QL   K
Sbjct: 274  NIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHK 333

Query: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER- 1666
            EE+      +  A  +L EA +    E+  K + +++++  + +L     ELN+   E+ 
Sbjct: 334  EEV------LETADKELGEAKK----EIKRKLSEMQDLEETMAKLQL---ELNLCQKEKE 380

Query: 1667 --------KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQ 1718
                    K+ L  +  ++E+E++ L   +   +  + +L   ++ ++LE+    G+K +
Sbjct: 381  RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEH----GIK-R 435

Query: 1719 HDQRVSELEKTQVAVLEE----KLELENLQQISQQ-------------------QKGEIE 1755
             D+  S L+     + EE    K ELE LQ I Q+                   +KG+  
Sbjct: 436  RDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYN 495

Query: 1756 WQKQLLERDKREIERMTAESRA----LQSCVECLSKEKEDL-------QEKCDIWEKKLA 1804
             +   + R++ E++RM          +QS V+ L+ E++ L       QE+     K+  
Sbjct: 496  SEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555

Query: 1805 QTK---RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI-------SA 1854
            QT     +++  E+  ++  S+L ++      L+++L+ +    L   +++       + 
Sbjct: 556  QTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTC 615

Query: 1855 MQQQLQEKREAVNS----LQEELANVQDHLNLAKQDLLHT---TKHQDVLLSE----QTR 1903
            +  QL+ ++  + S    ++E + ++++ L +  Q   H    + HQ   ++       +
Sbjct: 616  VNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQ 675

Query: 1904 LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK 1963
            LQ+ + ++ +R    + E E+ Q Q+++L+ +I+E  LK+  Q+            EE+ 
Sbjct: 676  LQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD------------EEAH 723

Query: 1964 LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQT 2023
            +    + + +++    +E  D+K+             E++  LQE      + EK ++Q 
Sbjct: 724  VMKKTIGVIDKEKDFLQETVDEKT-------------EKIANLQEN---LANKEKAVAQM 767

Query: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
            K  +SE E  + +    L+   +E +S       LR Q     K+ ++   S + A K  
Sbjct: 768  KIMISECESSVNQLKETLVNRDREINS-------LRRQLDAAHKELDEVGRSREIAFKEN 820

Query: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQM-QYEYTELKKQMAN 2142
            R +L+ +L    +EN  I  E   +E   Q+  E   R+ K + ++ ++E     K+  N
Sbjct: 821  R-RLQDDLATMARENQEISLE---LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKEN 876

Query: 2143 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 2202
            Q  L+R QM  + A        + E  +S   L         +L +I     +L   +E 
Sbjct: 877  QDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRL---------ELLSIDTERRHLRERVEL 927

Query: 2203 LKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEV 2262
            L++ +   +N     E    S    M        L E+LRH+ED  KA + + +S   E+
Sbjct: 928  LEKEIQEHINAHHAYESQISSMAKAMSR------LEEELRHQEDE-KATVLNDLSSLREL 980

Query: 2263 LIK 2265
             IK
Sbjct: 981  CIK 983



 Score =  105 bits (263), Expect = 4e-22
 Identities = 148/803 (18%), Positives = 363/803 (45%), Gaps = 86/803 (10%)

Query: 1317 EHHNLENEVSRLE---DIMQHLKSKKREERWMRASKR----QSEKEMEELHHNIDDLLQE 1369
            E  +LE  +++L+   ++ Q  K +  +E  +++       Q E+E + L   ++     
Sbjct: 357  EMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT 416

Query: 1370 KKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI-EKSLKHHEDIVDEIECIEK 1426
            ++ L  EVE   L   +++R +    +D  ++ +  E +  +K L+  + I+    C   
Sbjct: 417  ERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTS 476

Query: 1427 TLLKRRSEL-READRLLAEAE-SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
               + +S + R  ++    +E  +++  +++ +  +E+F   ++ +   +S+ + L    
Sbjct: 477  YSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERF---EKYMEDIQSNVKLLTAER 533

Query: 1485 QETAVNLVKADQQLRSLQADA-KDLEQHKI-----KQEEI-LKEINKIVAAKDSDFQCLS 1537
             + +V   +A ++L +L+ ++ +    H I     K++E+ L ++ +I+A K++  + L 
Sbjct: 534  DKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLE 593

Query: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLK---ESEVLLQAKRAELEKLKSQVTSQQQ 1594
              +E       +L+K IE      +H L+  K   +S+VL+   +  +E L++++  Q Q
Sbjct: 594  HIEEVSLFGKSELEKTIEHLTC-VNHQLESEKYELKSKVLIM--KETIESLENKLKVQAQ 650

Query: 1595 EMAVLDRQLGHKKEE---LHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
            + + +     H+K E   L ++   + ++  D Q  L +   E+      I+ ++  ++E
Sbjct: 651  KFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDE 710

Query: 1652 LSFQKGELNVQISERKTQLTLIKQEI--------EKEEE--NLQVVLRQMSKHKTELKNI 1701
            L+ +    + +    K  + +I +E         EK E+  NLQ  L    K   ++K +
Sbjct: 711  LNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIM 770

Query: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
            +   +   ++L+   +  D+ ++ L +   A  +E  E+   ++I+ ++   ++     +
Sbjct: 771  ISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATM 830

Query: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
             R+ +EI      S  L++ V+    EKE+++ +   +  ++++ + ++AA E+ ++   
Sbjct: 831  ARENQEI------SLELEAAVQ----EKEEMKSRVHKYITEVSRWESLMAAKEKENQDLL 880

Query: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
               + L       + +  Q   +  S+  ++ ++  + +  RE V  L++E   +Q+H+N
Sbjct: 881  DRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKE---IQEHIN 937

Query: 1882 L--AKQDLLHTTKHQDVLLSEQTRLQKD-----ISEWANRFEDCQKEEETKQQQLQVLQN 1934
               A +  + +       L E+ R Q+D     +++ ++  E C K +  K    Q L +
Sbjct: 938  AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997

Query: 1935 EIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLS 1994
            +            + F+R+  E E+ +S+ +  K  L  ++H ++   +   +  D+   
Sbjct: 998  K-----------NLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFH 1046

Query: 1995 KVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD 2054
              L + E+              +  +   K +L+  E +L  +S E   L+ +   ++ D
Sbjct: 1047 SHLTSHEK--------------DTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTD 1092

Query: 2055 FSLLRNQFLTERKKAEKQVASLK 2077
            +  L+ Q  TER + E+ +  ++
Sbjct: 1093 YDALKRQISTERYERERAIQEMR 1115



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 169/824 (20%), Positives = 339/824 (41%), Gaps = 147/824 (17%)

Query: 322  EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKID-AKFEPLNYYPSEYAEIDK 380
            E+L SDL    E L+Q  +   +A ++    +  L  YK++ A+    N     Y E+ K
Sbjct: 34   EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENN--ELYLELMK 91

Query: 381  APDESP-YIGKSRYKRNMFATESY---IIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
              + S  ++ + +      A E+     +++  A ++K +E + + +N+ +         
Sbjct: 92   LREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQ-------- 143

Query: 437  TQLEDKEKKISAAQTRLSELHDEIEK--AEQQILRATEEFKQLEEAIQLKKISEAG---- 490
             QL++K             LH  ++    +++ +    +  Q++E +   ++S       
Sbjct: 144  -QLQEKN------------LHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQP 190

Query: 491  -----KDLLY---KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
                  DLL     ++    Q V++L+++   +E  +    ++I  +++EI+ L +A+D 
Sbjct: 191  DDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDG 250

Query: 543  LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
               + P    ++++    E+ +  +N Q   L+              +  KDLE+++ E 
Sbjct: 251  --GRSPDVLSLESRNKTNEKLIAHLNIQVDFLQ--------------QANKDLEKRIRE- 293

Query: 603  QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
                              L E   T+  +     N       + E L Q LTE++Q   Q
Sbjct: 294  ------------------LMETKETVTSEVVNLSN-------KNEKLCQELTEIDQLAQQ 328

Query: 663  LEIVAMDA-ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQ 721
            LE    +  E   KEL E +       E+   L + Q DL    A+L+  LNL   E  +
Sbjct: 329  LERHKEEVLETADKELGEAKK------EIKRKLSEMQ-DLEETMAKLQLELNLCQKEKER 381

Query: 722  LKEEL----EKVTRLTQLEQ--------------SALQAELEKERQALKNALGKAQFSEE 763
            L +EL    +  T + QLEQ              +  Q  LE ER  L++ +      + 
Sbjct: 382  LSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGI------KR 435

Query: 764  KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAAR-VDELRRKLKL 822
            +++  S L   LK ++++ +  K++L+     L H++         +AR    + R  + 
Sbjct: 436  RDRSPSRLDTFLKGIEEERDYYKKELE----RLQHIIQRRSCSTSYSAREKSSIFRTPEK 491

Query: 823  GTGEMNIHS---PSDVLGKSLADLQKQFSEILARSKW---ERDEAQVRERKLQEEMALQQ 876
            G     IH      D L + L   +K   +I +  K    ERD+  V   + QEE++   
Sbjct: 492  GDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS--- 548

Query: 877  EKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQ 936
               A  +E  +      + + M  +K    + ++++  E   L+E L+ +EE+      +
Sbjct: 549  ---ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605

Query: 937  LQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTI 996
            L++  E    +  QL   + + K +    +E +  L+ +L    K  A        + + 
Sbjct: 606  LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL----KVQAQKFSHVAGDSSH 661

Query: 997  AKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
             K ++ SL     +I  E+ +  +  + +  + +    +L  A+A+I++L+  + +   +
Sbjct: 662  QKTEVNSL-----RIVNEQLQ--RSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLK 714

Query: 1057 FRLEMEKTGVGTGANSQVLEIEK--LNETMERQRTEIARLQNVL 1098
               + E+  V       V++ EK  L ET++ +  +IA LQ  L
Sbjct: 715  MTSQDEEAHV-MKKTIGVIDKEKDFLQETVDEKTEKIANLQENL 757



 Score = 81.6 bits (200), Expect = 8e-15
 Identities = 171/877 (19%), Positives = 361/877 (41%), Gaps = 141/877 (16%)

Query: 257  TQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ-DKLNKSLKEEAM 315
            T ++  A     ++ +++  +DLEK++ E  E K   T  +  + N+ +KL + L E   
Sbjct: 265  TNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQ 324

Query: 316  LQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEY 375
            L +Q     +  L T ++ L +   E+ R   +  +LE+ +A  +++     LN    E 
Sbjct: 325  LAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLE-----LNLCQKEK 379

Query: 376  AEID-----KAPDESPYIGKSRYKRNMF-ATESYIIDSAQ-AVQIKKMEPDEQLRNDHMN 428
              +      K+  E+      + K+ +    ES+ +   Q  +++++M  +  ++     
Sbjct: 380  ERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRD-- 437

Query: 429  LRGHTPLDTQLEDKEKKISAAQTRL----------------------------------S 454
             R  + LDT L+  E++    +  L                                  S
Sbjct: 438  -RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNS 496

Query: 455  ELHDEIEKAEQQILRATEEFKQLEEAIQLK-KISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
            E+H +I +   ++ R  E F++  E IQ   K+  A +D L    +   + ++ LR+E+ 
Sbjct: 497  EIH-QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555

Query: 514  ------DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQ 563
                  ++   MEK+K E+A     + DL+  +   ++   K  H++      KS  E+ 
Sbjct: 556  QTTAPHNIVSLMEKEK-ELA-----LSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT 609

Query: 564  LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL----------------TEGQIAAN 607
            ++ +     QLES   E+ S++    E I+ LE +L                 + ++ + 
Sbjct: 610  IEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSL 669

Query: 608  EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
              + + L+  +   Q  L   +G+   AQ + + L ++ + L  ++T  ++E     ++ 
Sbjct: 670  RIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEE---AHVMK 726

Query: 668  MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE--- 724
                 + KE   L+  + E+ E  A+LQ+   +     A+++  ++  ++  NQLKE   
Sbjct: 727  KTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLV 786

Query: 725  ------------------ELEKVTRLTQL---EQSALQ---AELEKERQALKNALGKAQF 760
                              EL++V R  ++   E   LQ   A + +E Q +   L  A  
Sbjct: 787  NRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAA-- 844

Query: 761  SEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHL-------NHVVDGLVRPEEVAARV 813
             +EKE+  S +H  +  +    +L+  + K+ Q+ L       N   D  V+  +     
Sbjct: 845  VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904

Query: 814  DELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE-ILARSKWERDEAQVRE--RKLQE 870
              +R +L      ++I +    L + +  L+K+  E I A   +E   + + +   +L+E
Sbjct: 905  SSVRLEL------LSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEE 958

Query: 871  EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQ 930
            E+  Q+++ AT   +     E  ++     D        QQ+ ++    +  +  +E ++
Sbjct: 959  ELRHQEDEKATVLNDLSSLRELCIKLDSGKD-----IMTQQLNSKNLEFERVVVELENVK 1013

Query: 931  GLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA 990
              +DL  ++   E+  +   L  L    + ++  S       D E++ LK+ +  S+   
Sbjct: 1014 SESDLLKKQLSNERHTV-KNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKL 1072

Query: 991  TA---ELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
            T+   E T+ + ++  L      + ++ + E  E ER
Sbjct: 1073 TSQSRENTMLRAKVAQLQTDYDALKRQISTERYERER 1109



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 50/220 (22%), Positives = 91/220 (41%), Gaps = 20/220 (9%)

Query: 908  RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQE 967
            RIQ+++ E+H LQE L  ME   G+ D   Q        I  + RE+E+     D     
Sbjct: 205  RIQELQQEVHQLQEKLAMME--SGVRDYSKQ--------IELREREIERLSVALDGGRSP 254

Query: 968  QVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSR 1027
             V  L+   K  +K +A        ++   +   K L   + ++ + +     E    S 
Sbjct: 255  DVLSLESRNKTNEKLIAH----LNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSN 310

Query: 1028 KAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVL-EIEKLNETMER 1086
            K  +  ++LT  +   +L Q L R K E      ++ G       + L E++ L ETM +
Sbjct: 311  KNEKLCQELTEID---QLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAK 367

Query: 1087 QRTEIARLQNVLDLTGSD--NKGGFENVLEEIAELRREVS 1124
             + E+   Q   +    +   K   E V+ ++ + ++ +S
Sbjct: 368  LQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLS 407



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 108/563 (19%), Positives = 229/563 (40%), Gaps = 65/563 (11%)

Query: 567  MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLG 626
            + ++Y  +  RLD++  R    T E   L E+L    +   E+L++              
Sbjct: 5    VERKYINIRKRLDQLGYRQTL-TVECLPLVEKLFSDLVHTTESLRQS------------- 50

Query: 627  TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA-ENMRKELAELESALQ 685
              K  A +A+ E        E        + +E ++L +  M   E+  + + EL+++L+
Sbjct: 51   --KLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLK 108

Query: 686  EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE-LEKVTRLTQLEQSALQAEL 744
            +     A L+      +     LE     ++    QL+E+ L  V +    ++ ++    
Sbjct: 109  KCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIA--F 166

Query: 745  EKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQDDN-NLLKQQLKDFQNHLNHVVDG 802
             ++R  +   +  ++ S     Q +    A L  + D+    L+Q++   Q  L  +  G
Sbjct: 167  RRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESG 226

Query: 803  LVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
            +    + + +++   R+++  +  ++     DVL  SL    K   +++A    + D  Q
Sbjct: 227  V---RDYSKQIELREREIERLSVALDGGRSPDVL--SLESRNKTNEKLIAHLNIQVDFLQ 281

Query: 863  VRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQEN 922
               + L++ +            E  +  E      +N   +    ++ Q   EI  L + 
Sbjct: 282  QANKDLEKRI-----------RELMETKETVTSEVVNLSNKNE--KLCQELTEIDQLAQQ 328

Query: 923  L-KSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKK 981
            L +  EE+    D +L EA +E +R L+++++LE+      AK Q ++    KE ++L  
Sbjct: 329  LERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETM----AKLQLELNLCQKEKERL-- 382

Query: 982  AVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEA 1041
                SD+L      + K  L+++   V ++ QE+    ++ E F    A   R LT    
Sbjct: 383  ----SDEL------LVKSDLETV---VHQLEQEKQRLSKKVESF----AVTERQLTLEVE 425

Query: 1042 EIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIA-RLQNVLDL 1100
             + L   + R+     RL+    G+    +    E+E+L   ++R+    +   +    +
Sbjct: 426  RMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSI 485

Query: 1101 TGSDNKGGFENVLEEIAELRREV 1123
              +  KG + + + +I   R E+
Sbjct: 486  FRTPEKGDYNSEIHQITRERDEL 508


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  157 bits (398), Expect = 9e-38
 Identities = 219/1048 (20%), Positives = 447/1048 (42%), Gaps = 124/1048 (11%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ +  + ++     + A KR+ E E  EL  +IDDL      +E E       V+
Sbjct: 923  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 982

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
               ++   +D  +  L  E   +K+L+  H+  +D+++  E    TL K + +L ++ D 
Sbjct: 983  NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039

Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
            L    E E +L    E+ K  +E     A+ S++  E++ ++L+ + ++    +     +
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099

Query: 1498 LRSLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            +   QA    L Q KIK+ +  ++E+ + + A+ +      K++  L+ EL+++ + +E 
Sbjct: 1100 IEDEQALGIQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQQ 1594
            A       +++ K+ E   Q  R +LE+                      L  Q+ + Q+
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 1595 EMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
                L+++    K E+  L  ++    +AK +L++  R  E +++E  +   E + L+ +
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL------KNIL-DM 1704
            L+ Q+G L  +  E   QL   +  + +     Q   +Q+ + K +L      KN L   
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 1705 LQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIE 1755
            LQ   H+   L+ Q++         QR      T+VA    K E + +Q+  + ++ + +
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 1756 WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ-------EKCDIWEKKLAQTKR 1808
               Q L+  +  +E + A+  +L+   + L  E EDL          C   +KK     +
Sbjct: 1399 LA-QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457

Query: 1809 VLAAAEENSKMEQSNLEKLELNVRKL-----------QQELDQLN---RDKLSLHNDISA 1854
            +LA  ++  +   + LE  +   R L           ++ LDQL    R+  +L  +IS 
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517

Query: 1855 MQQQLQEKREAVNSLQEELANVQD---HLNLAKQDLLHTTKHQD-VLLSEQTRLQKDISE 1910
            + +Q+ E  + ++ L++    V+     L  A ++   + +H++  +L  Q  L +  SE
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577

Query: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
               +    +K+EE  Q         ++ N +++V  E M   L  E  S    +   K  
Sbjct: 1578 VDRKI--AEKDEEIDQ---------LKRNHIRIV--ESMQSTLDAEIRSRNDAIRLKK-- 1622

Query: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
                  ++E +L + + +L+        A E +R  +  +   +  +  L    R   + 
Sbjct: 1623 ------KMEGDLNEMEIQLNHANR---MAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673

Query: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKN 2090
            ++QL         LQ E + +RA       Q    RK AE+++    E +++  +Q    
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 2091 LLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQ 2150
            +  +K+  + I +    +E + Q+      +  K +        ELKK+      LER +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1789

Query: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT 2210
              +   ++ L+  + +  + +LK   + + +L A       R   LEGE+ES ++     
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA-------RVRELEGEVESEQKRNAEA 1842

Query: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQT 2270
            + +G  + +    ++    E  R   LR  L+   D+L+A+++    +QAE   + + Q+
Sbjct: 1843 V-KGLRKHERRVKELTYQTEEDRKNILR--LQDLVDKLQAKVK-SYKRQAE---EAEEQS 1895

Query: 2271 EGTLHSLRRQVDALGELVTSTSADSASS 2298
               L   R+    L E      AD A S
Sbjct: 1896 NTNLAKFRKLQHELEE--AEERADIAES 1921



 Score =  154 bits (390), Expect = 7e-37
 Identities = 202/1027 (19%), Positives = 445/1027 (43%), Gaps = 126/1027 (12%)

Query: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
            ++ L+   E EK +     + +E + I+  L K  ++ +E +  +     E +  + + +
Sbjct: 842  IKPLLKSAETEKEMA---TMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898

Query: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
               E   DA+    Q      +LE + +E        ++    L A  + LE    + ++
Sbjct: 899  AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESEV 1573
             + ++   +A  + +      K + LTEE+  L + I    +     ++ H Q L +   
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD--- 1015

Query: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633
             LQA+  ++  L       +Q++  L+  L  +K+    L+  + +AK  L+  L+L + 
Sbjct: 1016 -LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK----LRMDLERAKRKLEGDLKLAQE 1070

Query: 1634 EVTEKCNHIREVKSLLEELSFQKG--------------ELNVQISERKTQLTLIKQEIEK 1679
             + +  N  +++   L++  F+                +L  +I E + ++  +++EIE 
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 1680 EEENLQVVLRQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSELE 1727
            E  +     +Q S    EL+ I + L         Q+E     E +  K++ D   + L+
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190

Query: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
                A    K   +++ ++  +Q   ++  KQ LE++K E   M  E   L S VE +SK
Sbjct: 1191 HEATAATLRKKHADSVAELG-EQIDNLQRVKQKLEKEKSE---MKMEIDDLASNVETVSK 1246

Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ---SNLEKLELNVRKLQQELD----- 1839
             K +L++ C   E +L++ K   +  EE  ++     +   +L+    +  ++LD     
Sbjct: 1247 AKGNLEKMCRTLEDQLSELK---SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303

Query: 1840 --QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
              QL+R K +    I  +++QL+E+ +A N+L   L + +   +L ++      + +  L
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 1898 LSEQTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMM 1949
                ++   ++++W  ++E    Q+ EE ++      Q+LQ  +  +E    K    E  
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423

Query: 1950 FQRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
             QRLQ E E    +  +   +   L ++Q   +K L + K K ++  +++ A+++  R+L
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483

Query: 2007 -----------QEEERWCESLEKTLSQTKRQLSEREQQLVE---KSGELLALQKEADSMR 2052
                       +E     E+L++     ++++S+  +Q+ E   +  EL  ++K+ +  +
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543

Query: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI---- 2108
             +      +     +  E ++  ++  L   +S++++ + E+ +E   +++    I    
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603

Query: 2109 ------ELVAQDNHERARRLMK-ELNQMQYEYTELKKQMA--------NQKDLERRQMEI 2153
                  E+ ++++  R ++ M+ +LN+M+ +     +  A         Q  L+  Q+ +
Sbjct: 1604 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL 1663

Query: 2154 SDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NL 2207
             DA+R+ + ++K+++    +  N    E+  +L A LE+ E      E EL    E   L
Sbjct: 1664 DDALRS-QEDLKEQLAMVERRANLLQAEI-EELRATLEQTERSRKIAEQELLDASERVQL 1721

Query: 2208 PFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAE 2261
              T N      K    +  I       E + ++ R+ E++ K      A +   + K+ +
Sbjct: 1722 LHTQNTSLINTKKKL-ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780

Query: 2262 V---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQN 2317
                L + K+  E T+  L+ ++D   +L     A       + +LE+ + E + ++   
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQL-----ALKGGKKQIQKLEARVRELEGEVESE 1835

Query: 2318 QEKNASA 2324
            Q++NA A
Sbjct: 1836 QKRNAEA 1842



 Score =  120 bits (301), Expect = 2e-26
 Identities = 175/858 (20%), Positives = 359/858 (41%), Gaps = 142/858 (16%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRAS--KRQSE--KEMEELHHNIDDL-------LQE 1369
            L+ ++  L+  ++ L+ +   ER  RA   K++S+  +E+EE+   +++        ++ 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169

Query: 1370 KKSLECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSL 1411
             K  E E +++ R +++            R++  D +        N++ +  +LE EKS 
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229

Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
               E  +D++    +T+ K +  L +  R L +  SEL   +E+ +  +   T A+R  L
Sbjct: 1230 MKME--IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT-AQRGRL 1286

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
            QTES     +   +E  V+     Q  R  QA  + +E+ K + EE +K  N +  A  S
Sbjct: 1287 QTESGEFSRQLDEKEALVS-----QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341

Query: 1532 ---DFQCLSKKKEKLTEELQKLQKDI-----EMAERNEDHHLQVLKESEVLLQAKRAELE 1583
               D   L ++ E+  E   +LQ+ +     E+A+    +    ++ +E L +AK+    
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK---- 1397

Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1643
            KL  ++ + ++ +  ++ +    ++    LQ  +     D++           ++ N  +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457

Query: 1644 EVKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
             +    ++      EL     E +   T+L  IK   E+  + L+ + R+    + E+ +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517

Query: 1701 ILDMLQLEN---HELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGE 1753
            + + +       HEL+ +K Q +Q   EL    E+ + ++  E+ ++  +Q    Q K E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577

Query: 1754 IEWQKQLLERDK----------REIERMT----AESRALQSCVECLSKEKEDLQEKCDIW 1799
            ++  +++ E+D+          R +E M     AE R+    +    K + DL E     
Sbjct: 1578 VD--RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM---- 1631

Query: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
            E +L    R+ A A  N +  Q  L+  +++       LD   R +  L   ++ ++++ 
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIH-------LDDALRSQEDLKEQLAMVERRA 1684

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEWA 1912
               +  +  L+  L   +    +A+Q+LL  ++   +L ++ T       +L+ DIS+  
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSKV 1969
               ED           LQ  +N  E+ K  +    MM + L+KE+++    E   +  + 
Sbjct: 1745 GEMEDI----------LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1794

Query: 1970 TLKEQQ-------------------------HQLEKELTDQKSKLDQVLSKVLAAEERVR 2004
            T+K+ Q                          +LE E+  ++ +  + +  +   E RV+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 2005 TLQ---EEER--------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
             L    EE+R          + L+  +   KRQ  E E+Q      +   LQ E +    
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914

Query: 2054 DFSLLRNQFLTERKKAEK 2071
               +  +Q    R K+ +
Sbjct: 1915 RADIAESQVNKLRVKSRE 1932



 Score =  117 bits (292), Expect = 2e-25
 Identities = 209/981 (21%), Positives = 397/981 (40%), Gaps = 169/981 (17%)

Query: 248  ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK--KMIETE-ELKSKQTRFLEEIKNQD 304
            + LE + VT    +   +     E E L    E+  ++I+T+ +L++K     E  ++++
Sbjct: 877  KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936

Query: 305  KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
            ++N  L  +    +  C ELK D++          +ELT A   + E E+     K+   
Sbjct: 937  EINAELTAKKRKLEDECSELKKDID---------DLELTLA---KVEKEKHATENKVKNL 984

Query: 365  FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIK-------KME 417
             E +       A++ K             K+ +       +D  QA + K       K++
Sbjct: 985  TEEMAGLDETIAKLTKE------------KKALQEAHQQTLDDLQAEEDKVNTLTKAKIK 1032

Query: 418  PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
             ++Q+ +          L+  LE ++K     +    +L  +++ A++ I+    E +QL
Sbjct: 1033 LEQQVDD----------LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 478  EEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ 537
            +E  +LKK     K+     L  +++      ++AL ++L            QK+IK+LQ
Sbjct: 1083 DE--KLKK-----KEFEISNLQSKIE-----DEQALGIQL------------QKKIKELQ 1118

Query: 538  IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK---- 593
              I+ L+ +       +A ++  E+Q   ++++ +++  RL+E     + + E  K    
Sbjct: 1119 ARIEELEEEIEAE---RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175

Query: 594  -------DLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
                   DLEE   + +  A    KK  + V + L E +  ++    + + E  +++ E 
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEI 1234

Query: 647  ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
            + L   +  V + +  LE +    E+   +L+EL+S  +EQ  +   L   +G L     
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLED---QLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 707  ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFS----- 761
            E   +L+ ++A  +QL    +  T+  Q+E+  L+ +LE+E +A KNAL  A  S     
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQ--QIEE--LKRQLEEEIKA-KNALAHALQSSRHDC 1346

Query: 762  -------EEKEQENSELHAKL----------------------KHLQDDNNLLKQQLKDF 792
                   EE+++  +EL   L                      + L++    L Q+L+  
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406

Query: 793  QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA 852
            + H+  V       E+   R+      L L     N          +L   Q+ F +ILA
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN------AACAALDKKQRNFDKILA 1460

Query: 853  RSKWERDEAQVRERKLQEE---MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARI 909
              K + +E        Q+E   +  +  K+    EE     E       N  +   +   
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520

Query: 910  QQME--NEIHYLQENLKSMEEIQGLTDLQLQEA----DEEKERILAQLRELEKKKKLEDA 963
            Q  E    IH L++  K +E+ +      L+EA    + E+ +IL    EL + K   D 
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580

Query: 964  KSQEQVFGLDKELKKLK----KAVATSDKLATAELTIAKDQL---KSLHGTV--MKINQE 1014
            K  E+    D+E+ +LK    + V +      AE+    D +   K + G +  M+I   
Sbjct: 1581 KIAEK----DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636

Query: 1015 RAEEL-QEAERFSRK--------------AAQAARDLTRAEAEIELLQNLLRQKGEQFRL 1059
             A  +  EA R  R               A ++  DL    A +E   NLL+ + E+ R 
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696

Query: 1060 EMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAE 1118
             +E+T      A  ++L+  +  + +  Q T +   +  L+   S  +G  E++L+E   
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

Query: 1119 LRREVSYQNDYISSMADPFKR 1139
               +        + MA+  K+
Sbjct: 1757 AEEKAKKAITDAAMMAEELKK 1777



 Score =  114 bits (284), Expect = 1e-24
 Identities = 149/714 (20%), Positives = 314/714 (43%), Gaps = 106/714 (14%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
            NLE     LED +  LKSK+ E++ +      +  + Q+E     ++++E    +  L +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309

Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLM---------------TELEIEKSL-K 1412
             K++   ++EEL R +++  + K+ +   ++S                 ++ E++++L K
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLAE----AE----------SELSCTKEKTKN 1458
             + ++       E   ++R  EL EA + LA+    AE          + L  TK++ +N
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429

Query: 1459 AVEKF------TDAKRSLLQTESD-----AEELERRAQETAVNLVKADQQLRSLQADA-- 1505
             VE        T+A  + L  +         E +++ +ET   L  + ++ RSL  +   
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489

Query: 1506 -KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
             K+  +  + Q E LK  NK +  + SD      +  K   EL+K++K +E     E   
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKCE 1545

Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
            LQ  L+E+E  L+ +  ++ +++ ++   + E+   DR++  K EE+  L+ + ++    
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHIRIVES 1602

Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
            +Q  L   + E+  + + IR  K +   L E+  Q    N   +E        +  ++  
Sbjct: 1603 MQSTL---DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDT 1659

Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGL--KLQHDQRVSELEKTQVAVLE 1735
            + +L   LR     K +L  +    ++LQ E  EL+    + +  ++++E E    +   
Sbjct: 1660 QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1719

Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKE 1790
            + L  +N   I+ ++K E +  +   E +    E   AE +A ++  +        K+++
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779

Query: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENS-----KMEQSNLEKLELNVRKLQQELDQLNRDK 1845
            D     +  +K + QT + L    + +     K  +  ++KLE  VR+L+ E++      
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES----- 1834

Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
                        + +   EAV  L++    V++     ++D  +  + QD++     +LQ
Sbjct: 1835 ------------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV----DKLQ 1878

Query: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ-KERE 1958
              +  +  + E+ +++  T   + + LQ+E+EE + +    E    +L+ K RE
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 121/613 (19%), Positives = 248/613 (40%), Gaps = 87/613 (14%)

Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
            C++      E + S+ E  +Q   SK   E  +W    +  + +  EEL      L Q  
Sbjct: 1346 CDLLREQYEEEQESKAE--LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403

Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
            ++ E  VE ++      ++ K  +   VE LM ++E        ++K  ++ + I+ E  
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK 1463

Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
                     +E  +K      +EL +      E+  +L   K + KN  ++ +D    + 
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLE----QHKIKQEEILKEINKIVA 1527
            +      ELE+  ++      +    L   +A  +  E    + +++  ++  E+++ +A
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583

Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV-----LKESEVLLQ-AKRAE 1581
             KD +   L +   ++ E +Q    D E+  RN+   L+      L E E+ L  A R  
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642

Query: 1582 LEKLKSQVTSQQ-------------QEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEAL 1628
             E L++   +Q              +    L  QL   +   +LLQ  + + +A L++  
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702

Query: 1629 R---LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
            R   + E E+ +    ++ + +    L   K +L   IS+ + ++  I QE    EE  +
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762

Query: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL-----EKTQVAVLEEKLEL 1740
              +   +    ELK   D     +  L+ +K   +Q V +L     E  Q+A+   K ++
Sbjct: 1763 KAITDAAMMAEELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818

Query: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
            + L+   ++ +GE+E +++   R+   ++ +    R ++       ++++++    D+ +
Sbjct: 1819 QKLEARVRELEGEVESEQK---RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875

Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
            K  A+ K     AEE  +   +NL K     RKLQ EL                     +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKF----RKLQHEL---------------------E 1910

Query: 1861 EKREAVNSLQEEL 1873
            E  E  +  + ++
Sbjct: 1911 EAEERADIAESQV 1923



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 132/695 (18%), Positives = 298/695 (42%), Gaps = 44/695 (6%)

Query: 1644 EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD 1703
            ++K LL+    +K     +++  K +   IK E+ K E   + +  +M    T LK   D
Sbjct: 841  KIKPLLKSAETEK-----EMATMKEEFQKIKDELAKSEAKRKELEEKMV---TLLKEKND 892

Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLER 1763
            +      E +GL    ++R  +L KT++ +  +  E+    +  ++   E+  +K+ LE 
Sbjct: 893  LQLQVQAEAEGLA-DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 951

Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
            +  E+++   +     + VE   KEK   + K     +++A     +A   +  K  Q  
Sbjct: 952  ECSELKKDIDDLELTLAKVE---KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008

Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
             ++   +++  + +++ L + K+ L   +  ++  L+++++    L+     ++  L LA
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068

Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
            ++ ++     +  L  +  + + +IS   ++ ED Q      Q++++ LQ  IEE + ++
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128

Query: 1944 VQQEMMFQRLQKERESEESKLETSKVTLKE------QQHQLEKELTDQKSKLDQVLSK-V 1996
              +     + +K+R     +LE     L+E       Q ++ K+   +  K+ + L +  
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188

Query: 1997 LAAEERVRTLQEEE--------RWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
            L  E    TL+++            ++L++   + +++ SE + ++ + +  +  + K  
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248

Query: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
             ++      L +Q L+E K  E++   L   L  QR +L+    E  + +  + ++ A +
Sbjct: 1249 GNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEALV 1304

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
              +++      +++ +EL +   E  + K  +A+     R   ++       + E K E+
Sbjct: 1305 SQLSRGKQAFTQQI-EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 2169 RTSLKNLNQFLPELPADLEA-ILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHI 2227
            + +L   N  + +     E   ++R E LE   + L + L          E +N     +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH---VEAVNAKCASL 1420

Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQA---EVLIKGKRQTEGT---LHSLRRQV 2281
                 R +   E L    +R  A       KQ    ++L + K++ E T   L + +++ 
Sbjct: 1421 EKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA 1480

Query: 2282 DALGELVTSTSADSASSPSLSQLESSLTEDSQLGQ 2316
             +LG  +      +A   SL QLE+   E+  L Q
Sbjct: 1481 RSLGTELFKIK--NAYEESLDQLETLKRENKNLQQ 1513



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 161/724 (22%), Positives = 323/724 (44%), Gaps = 119/724 (16%)

Query: 245  RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK-KMIETEELKSKQTRFLEEIKNQ 303
            R +  L  Q    Q     F R  L+E E L   L + K   T++++  + +  EEIK +
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSR-QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332

Query: 304  DKLNKSL----------KEEAMLQKQSCEELKSDLNTKN-ELLKQKTIELTRACQKQYEL 352
            + L  +L          +E+   +++S  EL+  L+  N E+ + +T   T A Q+  EL
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392

Query: 353  EQ---ELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID--- 406
            E+   +LA  ++ A  E +    ++ A ++K         K R +  +   E  ++D   
Sbjct: 1393 EEAKKKLA-QRLQAAEEHVEAVNAKCASLEKT--------KQRLQNEV---EDLMLDVER 1440

Query: 407  --SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE 464
              +A A   KK    +++  +       T    +LE  +K+  +  T L ++ +  E++ 
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEET--HAELEASQKEARSLGTELFKIKNAYEESL 1498

Query: 465  QQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQ 522
             Q+     E K L++ I    ++I+E GK +   +     ++  ++ QE  +L+  +E+ 
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-----KIKKQVEQEKCELQAALEEA 1553

Query: 523  KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY----QQLESRL 578
            +  +  ++ +I  +Q+ ++ + S+      +  + + K++++D + + +    + ++S L
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSE------VDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607

Query: 579  D-EILSR-----IAKETE-EIKDLEEQLTEGQIAANEALK--KDLEGVISGLQEYLGTIK 629
            D EI SR     + K+ E ++ ++E QL      A EAL+  ++ +G++   Q +L    
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD--- 1664

Query: 630  GQATQAQNECRK---LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQE 686
              A ++Q + ++   + + +  LLQ   E+E+ R  LE      +   +EL +    +Q 
Sbjct: 1665 -DALRSQEDLKEQLAMVERRANLLQ--AEIEELRATLEQTERSRKIAEQELLDASERVQL 1721

Query: 687  QHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEK 746
             H  N SL  T+  L              + + +Q++ E+E +       Q A  AE EK
Sbjct: 1722 LHTQNTSLINTKKKL--------------ETDISQMQGEMEDIL------QEARNAE-EK 1760

Query: 747  ERQALKNALGKAQFSEE--KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD--- 801
             ++A+ +A   A  +EE  KEQ+ S       HL+     ++Q +KD Q  L+       
Sbjct: 1761 AKKAITDA---AMMAEELKKEQDTSA------HLERMKKNMEQTVKDLQLRLDEAEQLAL 1811

Query: 802  --GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLG-KSLADLQKQFSEILARSKWER 858
              G  + +++ ARV EL        GE+      +    K L   +++  E+     ++ 
Sbjct: 1812 KGGKKQIQKLEARVRELE-------GEVESEQKRNAEAVKGLRKHERRVKELT----YQT 1860

Query: 859  DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHY 918
            +E +    +LQ+ +   Q K+ + + +  +A E++      F K QHE    +   +I  
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE 1920

Query: 919  LQEN 922
             Q N
Sbjct: 1921 SQVN 1924



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 129/612 (21%), Positives = 256/612 (41%), Gaps = 108/612 (17%)

Query: 564  LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE-QLTEGQIAANEALKKDLEGVISGLQ 622
            +++ +  + +L  ++  +L     E E     EE Q  + ++A +EA +K+LE  +  L 
Sbjct: 828  MNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLL 887

Query: 623  EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
            +    ++    Q Q E   L D +E   Q +    Q   +++ V   AE+  +  AEL +
Sbjct: 888  KEKNDLQ---LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 944

Query: 683  ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQLEQS 738
              ++  +  + L++   DL    A++E   +  + +   L EE+    E + +LT+ E+ 
Sbjct: 945  KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK-EKK 1003

Query: 739  ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
            ALQ   E  +Q L +         E+++ N+   AK+K        L+QQ+ D +  L  
Sbjct: 1004 ALQ---EAHQQTLDD------LQAEEDKVNTLTKAKIK--------LEQQVDDLEGSLE- 1045

Query: 799  VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
                    +E   R+D  R K KL  G++ +        +S+ D++            E+
Sbjct: 1046 --------QEKKLRMDLERAKRKL-EGDLKLAQ------ESIMDIEN-----------EK 1079

Query: 859  DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI-- 916
             +   + +K + E++  Q K+           E+AL  ++    ++ +ARI+++E EI  
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIED---------EQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 917  ----------------HYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK---- 956
                              L+E  + +EE  G T  Q++   + +       R+LE+    
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190

Query: 957  --------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
                    +KK  D+ ++  EQ+  L +  +KL+K   +  K+   +L    + +    G
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEMKMEIDDLASNVETVSKAKG 1249

Query: 1007 TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK--- 1063
             + K+ +   ++L E +    +  +   DLT     ++       + GE  R   EK   
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ------TESGEFSRQLDEKEAL 1303

Query: 1064 -TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFENVLEEIAEL 1119
             + +  G  +   +IE+L   +E +      L + L  +  D    +  +E   E  AEL
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 1120 RREVSYQNDYIS 1131
            +R +S  N  ++
Sbjct: 1364 QRALSKANTEVA 1375



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 73/363 (20%), Positives = 159/363 (43%), Gaps = 48/363 (13%)

Query: 270  EEVERLERD---LEKKMIET--EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEEL 324
            EE+++L+R+   + + M  T   E++S+      + K +  LN+   +     + + E L
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 325  KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
            ++  NT+  +LK   I L  A + Q +L+++LA  +  A     N   +E  E+    ++
Sbjct: 1647 RNYRNTQG-ILKDTQIHLDDALRSQEDLKEQLAMVERRA-----NLLQAEIEELRATLEQ 1700

Query: 385  SPYIGKSRYKRNMFATESYIIDSAQAVQI------KKMEPDEQLRNDHMNLRGHTP-LDT 437
            +        +R+    E  ++D+++ VQ+        +   ++L  D   ++G    +  
Sbjct: 1701 T--------ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ 1752

Query: 438  QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEA------ 489
            +  + E+K   A T  + + +E++K +          K +E+ ++    ++ EA      
Sbjct: 1753 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812

Query: 490  -GKDLLYK------QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQI 538
             GK  + K      +L G ++   K   EA+    + E++ +E+  +    +K I  LQ 
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872

Query: 539  AIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
             +D L +K   +   K Q    E+Q +    ++++L+  L+E   R      ++  L  +
Sbjct: 1873 LVDKLQAKVKSY---KRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVK 1929

Query: 599  LTE 601
              E
Sbjct: 1930 SRE 1932


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  157 bits (398), Expect = 9e-38
 Identities = 219/1048 (20%), Positives = 447/1048 (42%), Gaps = 124/1048 (11%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            ++++++ +  + ++     + A KR+ E E  EL  +IDDL      +E E       V+
Sbjct: 923  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 982

Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
               ++   +D  +  L  E   +K+L+  H+  +D+++  E    TL K + +L ++ D 
Sbjct: 983  NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039

Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
            L    E E +L    E+ K  +E     A+ S++  E++ ++L+ + ++    +     +
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099

Query: 1498 LRSLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
            +   QA    L Q KIK+ +  ++E+ + + A+ +      K++  L+ EL+++ + +E 
Sbjct: 1100 IEDEQALGIQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQQ 1594
            A       +++ K+ E   Q  R +LE+                      L  Q+ + Q+
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 1595 EMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
                L+++    K E+  L  ++    +AK +L++  R  E +++E  +   E + L+ +
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL------KNIL-DM 1704
            L+ Q+G L  +  E   QL   +  + +     Q   +Q+ + K +L      KN L   
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 1705 LQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIE 1755
            LQ   H+   L+ Q++         QR      T+VA    K E + +Q+  + ++ + +
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 1756 WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ-------EKCDIWEKKLAQTKR 1808
               Q L+  +  +E + A+  +L+   + L  E EDL          C   +KK     +
Sbjct: 1399 LA-QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457

Query: 1809 VLAAAEENSKMEQSNLEKLELNVRKL-----------QQELDQLN---RDKLSLHNDISA 1854
            +LA  ++  +   + LE  +   R L           ++ LDQL    R+  +L  +IS 
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517

Query: 1855 MQQQLQEKREAVNSLQEELANVQD---HLNLAKQDLLHTTKHQD-VLLSEQTRLQKDISE 1910
            + +Q+ E  + ++ L++    V+     L  A ++   + +H++  +L  Q  L +  SE
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577

Query: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
               +    +K+EE  Q         ++ N +++V  E M   L  E  S    +   K  
Sbjct: 1578 VDRKI--AEKDEEIDQ---------LKRNHIRIV--ESMQSTLDAEIRSRNDAIRLKK-- 1622

Query: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
                  ++E +L + + +L+        A E +R  +  +   +  +  L    R   + 
Sbjct: 1623 ------KMEGDLNEMEIQLNHANR---MAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673

Query: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKN 2090
            ++QL         LQ E + +RA       Q    RK AE+++    E +++  +Q    
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 2091 LLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQ 2150
            +  +K+  + I +    +E + Q+      +  K +        ELKK+      LER +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1789

Query: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT 2210
              +   ++ L+  + +  + +LK   + + +L A       R   LEGE+ES ++     
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA-------RVRELEGEVESEQKRNAEA 1842

Query: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQT 2270
            + +G  + +    ++    E  R   LR  L+   D+L+A+++    +QAE   + + Q+
Sbjct: 1843 V-KGLRKHERRVKELTYQTEEDRKNILR--LQDLVDKLQAKVK-SYKRQAE---EAEEQS 1895

Query: 2271 EGTLHSLRRQVDALGELVTSTSADSASS 2298
               L   R+    L E      AD A S
Sbjct: 1896 NTNLAKFRKLQHELEE--AEERADIAES 1921



 Score =  154 bits (390), Expect = 7e-37
 Identities = 202/1027 (19%), Positives = 445/1027 (43%), Gaps = 126/1027 (12%)

Query: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
            ++ L+   E EK +     + +E + I+  L K  ++ +E +  +     E +  + + +
Sbjct: 842  IKPLLKSAETEKEMA---TMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898

Query: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
               E   DA+    Q      +LE + +E        ++    L A  + LE    + ++
Sbjct: 899  AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESEV 1573
             + ++   +A  + +      K + LTEE+  L + I    +     ++ H Q L +   
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD--- 1015

Query: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633
             LQA+  ++  L       +Q++  L+  L  +K+    L+  + +AK  L+  L+L + 
Sbjct: 1016 -LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK----LRMDLERAKRKLEGDLKLAQE 1070

Query: 1634 EVTEKCNHIREVKSLLEELSFQKG--------------ELNVQISERKTQLTLIKQEIEK 1679
             + +  N  +++   L++  F+                +L  +I E + ++  +++EIE 
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 1680 EEENLQVVLRQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSELE 1727
            E  +     +Q S    EL+ I + L         Q+E     E +  K++ D   + L+
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190

Query: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
                A    K   +++ ++  +Q   ++  KQ LE++K E   M  E   L S VE +SK
Sbjct: 1191 HEATAATLRKKHADSVAELG-EQIDNLQRVKQKLEKEKSE---MKMEIDDLASNVETVSK 1246

Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ---SNLEKLELNVRKLQQELD----- 1839
             K +L++ C   E +L++ K   +  EE  ++     +   +L+    +  ++LD     
Sbjct: 1247 AKGNLEKMCRTLEDQLSELK---SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303

Query: 1840 --QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
              QL+R K +    I  +++QL+E+ +A N+L   L + +   +L ++      + +  L
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 1898 LSEQTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMM 1949
                ++   ++++W  ++E    Q+ EE ++      Q+LQ  +  +E    K    E  
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423

Query: 1950 FQRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
             QRLQ E E    +  +   +   L ++Q   +K L + K K ++  +++ A+++  R+L
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483

Query: 2007 -----------QEEERWCESLEKTLSQTKRQLSEREQQLVE---KSGELLALQKEADSMR 2052
                       +E     E+L++     ++++S+  +Q+ E   +  EL  ++K+ +  +
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543

Query: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI---- 2108
             +      +     +  E ++  ++  L   +S++++ + E+ +E   +++    I    
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603

Query: 2109 ------ELVAQDNHERARRLMK-ELNQMQYEYTELKKQMA--------NQKDLERRQMEI 2153
                  E+ ++++  R ++ M+ +LN+M+ +     +  A         Q  L+  Q+ +
Sbjct: 1604 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL 1663

Query: 2154 SDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NL 2207
             DA+R+ + ++K+++    +  N    E+  +L A LE+ E      E EL    E   L
Sbjct: 1664 DDALRS-QEDLKEQLAMVERRANLLQAEI-EELRATLEQTERSRKIAEQELLDASERVQL 1721

Query: 2208 PFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAE 2261
              T N      K    +  I       E + ++ R+ E++ K      A +   + K+ +
Sbjct: 1722 LHTQNTSLINTKKKL-ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780

Query: 2262 V---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQN 2317
                L + K+  E T+  L+ ++D   +L     A       + +LE+ + E + ++   
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQL-----ALKGGKKQIQKLEARVRELEGEVESE 1835

Query: 2318 QEKNASA 2324
            Q++NA A
Sbjct: 1836 QKRNAEA 1842



 Score =  120 bits (301), Expect = 2e-26
 Identities = 175/858 (20%), Positives = 359/858 (41%), Gaps = 142/858 (16%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRAS--KRQSE--KEMEELHHNIDDL-------LQE 1369
            L+ ++  L+  ++ L+ +   ER  RA   K++S+  +E+EE+   +++        ++ 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169

Query: 1370 KKSLECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSL 1411
             K  E E +++ R +++            R++  D +        N++ +  +LE EKS 
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229

Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
               E  +D++    +T+ K +  L +  R L +  SEL   +E+ +  +   T A+R  L
Sbjct: 1230 MKME--IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT-AQRGRL 1286

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
            QTES     +   +E  V+     Q  R  QA  + +E+ K + EE +K  N +  A  S
Sbjct: 1287 QTESGEFSRQLDEKEALVS-----QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341

Query: 1532 ---DFQCLSKKKEKLTEELQKLQKDI-----EMAERNEDHHLQVLKESEVLLQAKRAELE 1583
               D   L ++ E+  E   +LQ+ +     E+A+    +    ++ +E L +AK+    
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK---- 1397

Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1643
            KL  ++ + ++ +  ++ +    ++    LQ  +     D++           ++ N  +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457

Query: 1644 EVKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
             +    ++      EL     E +   T+L  IK   E+  + L+ + R+    + E+ +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517

Query: 1701 ILDMLQLEN---HELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGE 1753
            + + +       HEL+ +K Q +Q   EL    E+ + ++  E+ ++  +Q    Q K E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577

Query: 1754 IEWQKQLLERDK----------REIERMT----AESRALQSCVECLSKEKEDLQEKCDIW 1799
            ++  +++ E+D+          R +E M     AE R+    +    K + DL E     
Sbjct: 1578 VD--RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM---- 1631

Query: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
            E +L    R+ A A  N +  Q  L+  +++       LD   R +  L   ++ ++++ 
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIH-------LDDALRSQEDLKEQLAMVERRA 1684

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEWA 1912
               +  +  L+  L   +    +A+Q+LL  ++   +L ++ T       +L+ DIS+  
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSKV 1969
               ED           LQ  +N  E+ K  +    MM + L+KE+++    E   +  + 
Sbjct: 1745 GEMEDI----------LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1794

Query: 1970 TLKEQQ-------------------------HQLEKELTDQKSKLDQVLSKVLAAEERVR 2004
            T+K+ Q                          +LE E+  ++ +  + +  +   E RV+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 2005 TLQ---EEER--------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
             L    EE+R          + L+  +   KRQ  E E+Q      +   LQ E +    
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914

Query: 2054 DFSLLRNQFLTERKKAEK 2071
               +  +Q    R K+ +
Sbjct: 1915 RADIAESQVNKLRVKSRE 1932



 Score =  117 bits (292), Expect = 2e-25
 Identities = 209/981 (21%), Positives = 397/981 (40%), Gaps = 169/981 (17%)

Query: 248  ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK--KMIETE-ELKSKQTRFLEEIKNQD 304
            + LE + VT    +   +     E E L    E+  ++I+T+ +L++K     E  ++++
Sbjct: 877  KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936

Query: 305  KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
            ++N  L  +    +  C ELK D++          +ELT A   + E E+     K+   
Sbjct: 937  EINAELTAKKRKLEDECSELKKDID---------DLELTLA---KVEKEKHATENKVKNL 984

Query: 365  FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIK-------KME 417
             E +       A++ K             K+ +       +D  QA + K       K++
Sbjct: 985  TEEMAGLDETIAKLTKE------------KKALQEAHQQTLDDLQAEEDKVNTLTKAKIK 1032

Query: 418  PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
             ++Q+ +          L+  LE ++K     +    +L  +++ A++ I+    E +QL
Sbjct: 1033 LEQQVDD----------LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 478  EEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ 537
            +E  +LKK     K+     L  +++      ++AL ++L            QK+IK+LQ
Sbjct: 1083 DE--KLKK-----KEFEISNLQSKIE-----DEQALGIQL------------QKKIKELQ 1118

Query: 538  IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK---- 593
              I+ L+ +       +A ++  E+Q   ++++ +++  RL+E     + + E  K    
Sbjct: 1119 ARIEELEEEIEAE---RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175

Query: 594  -------DLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
                   DLEE   + +  A    KK  + V + L E +  ++    + + E  +++ E 
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEI 1234

Query: 647  ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
            + L   +  V + +  LE +    E+   +L+EL+S  +EQ  +   L   +G L     
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLED---QLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 707  ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFS----- 761
            E   +L+ ++A  +QL    +  T+  Q+E+  L+ +LE+E +A KNAL  A  S     
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQ--QIEE--LKRQLEEEIKA-KNALAHALQSSRHDC 1346

Query: 762  -------EEKEQENSELHAKL----------------------KHLQDDNNLLKQQLKDF 792
                   EE+++  +EL   L                      + L++    L Q+L+  
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406

Query: 793  QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA 852
            + H+  V       E+   R+      L L     N          +L   Q+ F +ILA
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN------AACAALDKKQRNFDKILA 1460

Query: 853  RSKWERDEAQVRERKLQEE---MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARI 909
              K + +E        Q+E   +  +  K+    EE     E       N  +   +   
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520

Query: 910  QQME--NEIHYLQENLKSMEEIQGLTDLQLQEA----DEEKERILAQLRELEKKKKLEDA 963
            Q  E    IH L++  K +E+ +      L+EA    + E+ +IL    EL + K   D 
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580

Query: 964  KSQEQVFGLDKELKKLK----KAVATSDKLATAELTIAKDQL---KSLHGTV--MKINQE 1014
            K  E+    D+E+ +LK    + V +      AE+    D +   K + G +  M+I   
Sbjct: 1581 KIAEK----DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636

Query: 1015 RAEEL-QEAERFSRK--------------AAQAARDLTRAEAEIELLQNLLRQKGEQFRL 1059
             A  +  EA R  R               A ++  DL    A +E   NLL+ + E+ R 
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696

Query: 1060 EMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAE 1118
             +E+T      A  ++L+  +  + +  Q T +   +  L+   S  +G  E++L+E   
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

Query: 1119 LRREVSYQNDYISSMADPFKR 1139
               +        + MA+  K+
Sbjct: 1757 AEEKAKKAITDAAMMAEELKK 1777



 Score =  114 bits (284), Expect = 1e-24
 Identities = 149/714 (20%), Positives = 314/714 (43%), Gaps = 106/714 (14%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
            NLE     LED +  LKSK+ E++ +      +  + Q+E     ++++E    +  L +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309

Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLM---------------TELEIEKSL-K 1412
             K++   ++EEL R +++  + K+ +   ++S                 ++ E++++L K
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLAE----AE----------SELSCTKEKTKN 1458
             + ++       E   ++R  EL EA + LA+    AE          + L  TK++ +N
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429

Query: 1459 AVEKF------TDAKRSLLQTESD-----AEELERRAQETAVNLVKADQQLRSLQADA-- 1505
             VE        T+A  + L  +         E +++ +ET   L  + ++ RSL  +   
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489

Query: 1506 -KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
             K+  +  + Q E LK  NK +  + SD      +  K   EL+K++K +E     E   
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKCE 1545

Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
            LQ  L+E+E  L+ +  ++ +++ ++   + E+   DR++  K EE+  L+ + ++    
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHIRIVES 1602

Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
            +Q  L   + E+  + + IR  K +   L E+  Q    N   +E        +  ++  
Sbjct: 1603 MQSTL---DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDT 1659

Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGL--KLQHDQRVSELEKTQVAVLE 1735
            + +L   LR     K +L  +    ++LQ E  EL+    + +  ++++E E    +   
Sbjct: 1660 QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1719

Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKE 1790
            + L  +N   I+ ++K E +  +   E +    E   AE +A ++  +        K+++
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779

Query: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENS-----KMEQSNLEKLELNVRKLQQELDQLNRDK 1845
            D     +  +K + QT + L    + +     K  +  ++KLE  VR+L+ E++      
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES----- 1834

Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
                        + +   EAV  L++    V++     ++D  +  + QD++     +LQ
Sbjct: 1835 ------------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV----DKLQ 1878

Query: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ-KERE 1958
              +  +  + E+ +++  T   + + LQ+E+EE + +    E    +L+ K RE
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 121/613 (19%), Positives = 248/613 (40%), Gaps = 87/613 (14%)

Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
            C++      E + S+ E  +Q   SK   E  +W    +  + +  EEL      L Q  
Sbjct: 1346 CDLLREQYEEEQESKAE--LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403

Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
            ++ E  VE ++      ++ K  +   VE LM ++E        ++K  ++ + I+ E  
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK 1463

Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
                     +E  +K      +EL +      E+  +L   K + KN  ++ +D    + 
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523

Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLE----QHKIKQEEILKEINKIVA 1527
            +      ELE+  ++      +    L   +A  +  E    + +++  ++  E+++ +A
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583

Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV-----LKESEVLLQ-AKRAE 1581
             KD +   L +   ++ E +Q    D E+  RN+   L+      L E E+ L  A R  
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642

Query: 1582 LEKLKSQVTSQQ-------------QEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEAL 1628
             E L++   +Q              +    L  QL   +   +LLQ  + + +A L++  
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702

Query: 1629 R---LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
            R   + E E+ +    ++ + +    L   K +L   IS+ + ++  I QE    EE  +
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762

Query: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL-----EKTQVAVLEEKLEL 1740
              +   +    ELK   D     +  L+ +K   +Q V +L     E  Q+A+   K ++
Sbjct: 1763 KAITDAAMMAEELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818

Query: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
            + L+   ++ +GE+E +++   R+   ++ +    R ++       ++++++    D+ +
Sbjct: 1819 QKLEARVRELEGEVESEQK---RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875

Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
            K  A+ K     AEE  +   +NL K     RKLQ EL                     +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKF----RKLQHEL---------------------E 1910

Query: 1861 EKREAVNSLQEEL 1873
            E  E  +  + ++
Sbjct: 1911 EAEERADIAESQV 1923



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 132/695 (18%), Positives = 298/695 (42%), Gaps = 44/695 (6%)

Query: 1644 EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD 1703
            ++K LL+    +K     +++  K +   IK E+ K E   + +  +M    T LK   D
Sbjct: 841  KIKPLLKSAETEK-----EMATMKEEFQKIKDELAKSEAKRKELEEKMV---TLLKEKND 892

Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLER 1763
            +      E +GL    ++R  +L KT++ +  +  E+    +  ++   E+  +K+ LE 
Sbjct: 893  LQLQVQAEAEGLA-DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 951

Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
            +  E+++   +     + VE   KEK   + K     +++A     +A   +  K  Q  
Sbjct: 952  ECSELKKDIDDLELTLAKVE---KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008

Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
             ++   +++  + +++ L + K+ L   +  ++  L+++++    L+     ++  L LA
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068

Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
            ++ ++     +  L  +  + + +IS   ++ ED Q      Q++++ LQ  IEE + ++
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128

Query: 1944 VQQEMMFQRLQKERESEESKLETSKVTLKE------QQHQLEKELTDQKSKLDQVLSK-V 1996
              +     + +K+R     +LE     L+E       Q ++ K+   +  K+ + L +  
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188

Query: 1997 LAAEERVRTLQEEE--------RWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
            L  E    TL+++            ++L++   + +++ SE + ++ + +  +  + K  
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248

Query: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
             ++      L +Q L+E K  E++   L   L  QR +L+    E  + +  + ++ A +
Sbjct: 1249 GNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEALV 1304

Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
              +++      +++ +EL +   E  + K  +A+     R   ++       + E K E+
Sbjct: 1305 SQLSRGKQAFTQQI-EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 2169 RTSLKNLNQFLPELPADLEA-ILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHI 2227
            + +L   N  + +     E   ++R E LE   + L + L          E +N     +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH---VEAVNAKCASL 1420

Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQA---EVLIKGKRQTEGT---LHSLRRQV 2281
                 R +   E L    +R  A       KQ    ++L + K++ E T   L + +++ 
Sbjct: 1421 EKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA 1480

Query: 2282 DALGELVTSTSADSASSPSLSQLESSLTEDSQLGQ 2316
             +LG  +      +A   SL QLE+   E+  L Q
Sbjct: 1481 RSLGTELFKIK--NAYEESLDQLETLKRENKNLQQ 1513



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 161/724 (22%), Positives = 323/724 (44%), Gaps = 119/724 (16%)

Query: 245  RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK-KMIETEELKSKQTRFLEEIKNQ 303
            R +  L  Q    Q     F R  L+E E L   L + K   T++++  + +  EEIK +
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSR-QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332

Query: 304  DKLNKSL----------KEEAMLQKQSCEELKSDLNTKN-ELLKQKTIELTRACQKQYEL 352
            + L  +L          +E+   +++S  EL+  L+  N E+ + +T   T A Q+  EL
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392

Query: 353  EQ---ELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID--- 406
            E+   +LA  ++ A  E +    ++ A ++K         K R +  +   E  ++D   
Sbjct: 1393 EEAKKKLA-QRLQAAEEHVEAVNAKCASLEKT--------KQRLQNEV---EDLMLDVER 1440

Query: 407  --SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE 464
              +A A   KK    +++  +       T    +LE  +K+  +  T L ++ +  E++ 
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEET--HAELEASQKEARSLGTELFKIKNAYEESL 1498

Query: 465  QQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQ 522
             Q+     E K L++ I    ++I+E GK +   +     ++  ++ QE  +L+  +E+ 
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-----KIKKQVEQEKCELQAALEEA 1553

Query: 523  KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY----QQLESRL 578
            +  +  ++ +I  +Q+ ++ + S+      +  + + K++++D + + +    + ++S L
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSE------VDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607

Query: 579  D-EILSR-----IAKETE-EIKDLEEQLTEGQIAANEALK--KDLEGVISGLQEYLGTIK 629
            D EI SR     + K+ E ++ ++E QL      A EAL+  ++ +G++   Q +L    
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD--- 1664

Query: 630  GQATQAQNECRK---LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQE 686
              A ++Q + ++   + + +  LLQ   E+E+ R  LE      +   +EL +    +Q 
Sbjct: 1665 -DALRSQEDLKEQLAMVERRANLLQ--AEIEELRATLEQTERSRKIAEQELLDASERVQL 1721

Query: 687  QHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEK 746
             H  N SL  T+  L              + + +Q++ E+E +       Q A  AE EK
Sbjct: 1722 LHTQNTSLINTKKKL--------------ETDISQMQGEMEDIL------QEARNAE-EK 1760

Query: 747  ERQALKNALGKAQFSEE--KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD--- 801
             ++A+ +A   A  +EE  KEQ+ S       HL+     ++Q +KD Q  L+       
Sbjct: 1761 AKKAITDA---AMMAEELKKEQDTSA------HLERMKKNMEQTVKDLQLRLDEAEQLAL 1811

Query: 802  --GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLG-KSLADLQKQFSEILARSKWER 858
              G  + +++ ARV EL        GE+      +    K L   +++  E+     ++ 
Sbjct: 1812 KGGKKQIQKLEARVRELE-------GEVESEQKRNAEAVKGLRKHERRVKELT----YQT 1860

Query: 859  DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHY 918
            +E +    +LQ+ +   Q K+ + + +  +A E++      F K QHE    +   +I  
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE 1920

Query: 919  LQEN 922
             Q N
Sbjct: 1921 SQVN 1924



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 129/612 (21%), Positives = 256/612 (41%), Gaps = 108/612 (17%)

Query: 564  LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE-QLTEGQIAANEALKKDLEGVISGLQ 622
            +++ +  + +L  ++  +L     E E     EE Q  + ++A +EA +K+LE  +  L 
Sbjct: 828  MNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLL 887

Query: 623  EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
            +    ++    Q Q E   L D +E   Q +    Q   +++ V   AE+  +  AEL +
Sbjct: 888  KEKNDLQ---LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 944

Query: 683  ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQLEQS 738
              ++  +  + L++   DL    A++E   +  + +   L EE+    E + +LT+ E+ 
Sbjct: 945  KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK-EKK 1003

Query: 739  ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
            ALQ   E  +Q L +         E+++ N+   AK+K        L+QQ+ D +  L  
Sbjct: 1004 ALQ---EAHQQTLDD------LQAEEDKVNTLTKAKIK--------LEQQVDDLEGSLE- 1045

Query: 799  VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
                    +E   R+D  R K KL  G++ +        +S+ D++            E+
Sbjct: 1046 --------QEKKLRMDLERAKRKL-EGDLKLAQ------ESIMDIEN-----------EK 1079

Query: 859  DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI-- 916
             +   + +K + E++  Q K+           E+AL  ++    ++ +ARI+++E EI  
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIED---------EQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 917  ----------------HYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK---- 956
                              L+E  + +EE  G T  Q++   + +       R+LE+    
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190

Query: 957  --------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
                    +KK  D+ ++  EQ+  L +  +KL+K   +  K+   +L    + +    G
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEMKMEIDDLASNVETVSKAKG 1249

Query: 1007 TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK--- 1063
             + K+ +   ++L E +    +  +   DLT     ++       + GE  R   EK   
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ------TESGEFSRQLDEKEAL 1303

Query: 1064 -TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFENVLEEIAEL 1119
             + +  G  +   +IE+L   +E +      L + L  +  D    +  +E   E  AEL
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 1120 RREVSYQNDYIS 1131
            +R +S  N  ++
Sbjct: 1364 QRALSKANTEVA 1375



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 73/363 (20%), Positives = 159/363 (43%), Gaps = 48/363 (13%)

Query: 270  EEVERLERD---LEKKMIET--EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEEL 324
            EE+++L+R+   + + M  T   E++S+      + K +  LN+   +     + + E L
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 325  KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
            ++  NT+  +LK   I L  A + Q +L+++LA  +  A     N   +E  E+    ++
Sbjct: 1647 RNYRNTQG-ILKDTQIHLDDALRSQEDLKEQLAMVERRA-----NLLQAEIEELRATLEQ 1700

Query: 385  SPYIGKSRYKRNMFATESYIIDSAQAVQI------KKMEPDEQLRNDHMNLRGHTP-LDT 437
            +        +R+    E  ++D+++ VQ+        +   ++L  D   ++G    +  
Sbjct: 1701 T--------ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ 1752

Query: 438  QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEA------ 489
            +  + E+K   A T  + + +E++K +          K +E+ ++    ++ EA      
Sbjct: 1753 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812

Query: 490  -GKDLLYK------QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQI 538
             GK  + K      +L G ++   K   EA+    + E++ +E+  +    +K I  LQ 
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872

Query: 539  AIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
             +D L +K   +   K Q    E+Q +    ++++L+  L+E   R      ++  L  +
Sbjct: 1873 LVDKLQAKVKSY---KRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVK 1929

Query: 599  LTE 601
              E
Sbjct: 1930 SRE 1932


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  157 bits (397), Expect = 1e-37
 Identities = 232/1082 (21%), Positives = 468/1082 (43%), Gaps = 149/1082 (13%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEE--LHHNIDDLLQEKKSLECE- 1376
            NLE EVS  + +++  ++K  + + M   K QS +E +E  +   +D L Q K+    E 
Sbjct: 295  NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAER 354

Query: 1377 --------VEELHRTVQKRQQQKDFIDGNVESLMTELEI-EKSL----KHHEDIVDEIEC 1423
                     EEL +     QQ K  +   +E +  E EI E++L    K ++ + +    
Sbjct: 355  QRNEALYNAEELSKAF---QQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGL 411

Query: 1424 IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERR 1483
             +  L   + +LR+        + +L     K    + + T++++S+L+ ES+ E  +  
Sbjct: 412  YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEI 471

Query: 1484 AQETAVNLVKADQQLR---SLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKK 1539
             ++   +L+  +++L+   + Q +  DL Q +I+   + L+ + KI++      +    K
Sbjct: 472  LRD-KFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFK 530

Query: 1540 ----KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
                K +++    K  + I   E N+     V+ E  + L  K AE++KL + +T+ Q  
Sbjct: 531  SYLSKYQMSSFSNKEDRCIGCCEANK----LVISELRIKLAIKEAEIQKLHANLTANQLS 586

Query: 1596 MAVL---DRQLGHKKEELHL----LQGSMVQAKADLQEALRLG---ETEVTEKCNHIREV 1645
             +++   D Q   K   L      L G  V      Q    +    E E       I E+
Sbjct: 587  QSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEEL 646

Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
            ++ L ++  +  +L V ++ R +Q  LI++E+ ++  N   +  +M+K  ++L  +   L
Sbjct: 647  RTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQL 706

Query: 1706 Q----------LENHELQGLKLQHDQRVSELEKTQVAVLEEK--LELENLQQISQQQKGE 1753
            +           +N EL+   ++ ++++  LE T +    EK  L  E  ++I  +Q  E
Sbjct: 707  EEKIVAYSSIAAKNAELEQELMEKNEKIRSLE-TNINTEHEKICLAFEKAKKIHLEQHKE 765

Query: 1754 IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1813
            +E          ++IER+ A+             EK+D Q K         + ++ ++  
Sbjct: 766  ME----------KQIERLEAQ------------LEKKDQQFK---------EQEKTMSML 794

Query: 1814 EENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL 1873
            +++   +Q +LE L+   R L +   ++ ++ +     + A+Q Q+ E+   V  L    
Sbjct: 795  QQDIICKQHHLESLD---RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA- 850

Query: 1874 ANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVL- 1932
                  L + K++L+    H + L   + + +K + + +      QKE + K   LQ   
Sbjct: 851  ------LEICKEELV---LHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETS 901

Query: 1933 -QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQ 1991
             QN I ++ L+  QQ+ M Q    +      +LE ++  L++Q  +LE+EL  Q+    +
Sbjct: 902  EQNVILQHTLQ--QQQQMLQ----QETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE 955

Query: 1992 VLSKVLAAEERVRTLQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKE 2047
             L K+   EE+  +   E     +    L  T  Q K ++ + +++L +   E++ L+++
Sbjct: 956  KLRKM---EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 1012

Query: 2048 ADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMAT 2107
             ++     S L       + + EK+  ++KE  K+Q S  E  L E  Q+   ++ E+  
Sbjct: 1013 GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHS-TETELTEALQKREVLETEL-- 1069

Query: 2108 IELVAQDNHERARRLMKELNQ----MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSE 2163
                 Q+ H   +  +++L +    +Q     L+++    KDL     E    +   K E
Sbjct: 1070 -----QNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQE 1124

Query: 2164 VKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFS 2223
            +  E+  +LK  N  L +  A +  +        GE+E     L  T+ +   E K    
Sbjct: 1125 LL-EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK 1183

Query: 2224 QVHIMDEHWRG--EALREK----LRHRED--RLKAQLRHCMS--KQAEVLIKGKRQTEGT 2273
            Q+  +++  +   E LREK    L++ ++  +LK ++       K+ E ++K + Q   T
Sbjct: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243

Query: 2274 -----------LHSLRRQV-DALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
                       L   R QV ++  EL  +      +   + +L S L +  QL + ++ +
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAH 1303

Query: 2322 AS 2323
             +
Sbjct: 1304 GN 1305



 Score =  155 bits (392), Expect = 4e-37
 Identities = 200/1080 (18%), Positives = 461/1080 (42%), Gaps = 130/1080 (12%)

Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQ 1389
            D+++  K  KR ER    +   +E+  +        + ++ + ++ E E L R +   ++
Sbjct: 341  DLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK 400

Query: 1390 QKDFIDGNVESLMTELEIEKS----LKH---------------HEDIVDEIECIEKTLLK 1430
            +   +        +ELEI K     LK                + +++ ++    +++LK
Sbjct: 401  ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK 460

Query: 1431 RRSELREADRLLAEAESELSCTKE-KTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
              SEL   D +L +  S ++  +E K + A +   + +  L Q E ++  +E R+ E  +
Sbjct: 461  LESELENKDEILRDKFSLMNENRELKVRVAAQ---NERLDLCQQEIESSRVELRSLEKII 517

Query: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEE------------ILKEINKIVAAKDSDFQCL- 1536
            + +   ++L   ++     +      +E            ++ E+   +A K+++ Q L 
Sbjct: 518  SQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLH 577

Query: 1537 --------------------SKKKEKLTEELQKLQKDIEMAERNEDHHLQVL-KESEVLL 1575
                                S K   L  E  KL    ++AE  +D +   + K+ E   
Sbjct: 578  ANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGH-QVAESVKDQNQHTMNKQYEKER 636

Query: 1576 QAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEV 1635
            Q     +E+L++++   + E + L   + H+  +  L+Q  +++  ++  +     E+E+
Sbjct: 637  QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL----ESEM 692

Query: 1636 TEKCNHIREVKSLLEE-------LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVL 1688
            T+KC+ +  ++  LEE       ++ +  EL  ++ E+  ++  ++  I  E E + +  
Sbjct: 693  TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF 752

Query: 1689 RQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKT----QVAVLEEKLELENLQ 1744
             +  K   E    ++  Q+E  E Q  K   DQ+  E EKT    Q  ++ ++  LE+L 
Sbjct: 753  EKAKKIHLEQHKEMEK-QIERLEAQLEK--KDQQFKEQEKTMSMLQQDIICKQHHLESLD 809

Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESR--------ALQSCVECLSKEKEDLQEKC 1796
            ++  + KGE++ +    +   + ++   +E          AL+ C E L      L+   
Sbjct: 810  RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869

Query: 1797 DIWEKKLAQTKRVLAAAEENSKMEQSNLEKL-ELNV---RKLQQELDQLNRDKL------ 1846
            + +EK+L +    +   ++  K++  +L++  E NV     LQQ+   L ++ +      
Sbjct: 870  EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELE 929

Query: 1847 ----SLHNDISAMQQQLQEKREA----VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
                 L   +S ++Q+LQ++RE+    +  ++E+  +     +L +Q ++  T     + 
Sbjct: 930  DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVK 989

Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
             E  + ++++S+        +++ E K   L  L   +++ K +L ++    + L+K + 
Sbjct: 990  IEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH 1049

Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEK 2018
            S E++L  +    +  + +L+    + KS L Q+       ++   +L+E+    + L  
Sbjct: 1050 STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109

Query: 2019 TLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASL-- 2076
             L + K ++ +++Q+L+E    L     E     A  + L       R + E+++  L  
Sbjct: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169

Query: 2077 ---KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
               K  L+++    +   L  K +N+  ++++   E +   N +   +L KE+ + Q   
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNA--KEQLREKEFIMLQNEQEISQLKKEIERTQQRM 1227

Query: 2134 TELKKQMANQKDLERRQ----MEISDAMRTLKSEVKD------EIRTSLKNLNQFLPELP 2183
             E++  M  Q+     Q    +++   +R  + +V++      E R       + +  L 
Sbjct: 1228 KEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLS 1287

Query: 2184 ADLEAILERNENLEGELESLKENLPFT-MNEGPFEEKLN------FSQVHIMDEHWRGEA 2236
            ++LE + + ++  +     L E L  + + E   E ++        ++V  + E +  E 
Sbjct: 1288 SELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEM 1347

Query: 2237 LREKLRHREDRLKAQLRHCMSKQA-EVLIKGK---RQTEGTLHSLRRQVDALGELVTSTS 2292
            +  +  H + ++ A  +    +Q  E L K K    + + T+ +L +QV    E++ + +
Sbjct: 1348 ISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAAN 1407



 Score =  141 bits (356), Expect = 7e-33
 Identities = 235/1185 (19%), Positives = 501/1185 (42%), Gaps = 176/1185 (14%)

Query: 1299 PNFSIPFIPMGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRAS---KRQSEKE 1355
            P  S+P   +G +  +  +++N +NE   L   +  L+ + +   W   S   +  S   
Sbjct: 107  PGGSLPSDDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP 166

Query: 1356 MEELHHNIDDLLQEKKSLE-----------------CEVEELHRTVQKRQQQKDF----- 1393
             E   +  +    EK  L+                 C++       QK+ + K F     
Sbjct: 167  SENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAP 226

Query: 1394 IDGNVESLMTELEIEKS-----LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESE 1448
            +D  ++SL  +L   +      +  +  ++ + E I   L + R+++   +    +A S 
Sbjct: 227  VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS- 285

Query: 1449 LSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDL 1508
            +   +E+  N   + +   + L + E+  E+ ++   E   +L ++ ++   L+ D   L
Sbjct: 286  VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDL--L 343

Query: 1509 EQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVL 1568
            EQ K + +   ++ N+ +   +   +   + K+K+ E+L+K+Q + E+ ERN  +  +  
Sbjct: 344  EQTK-QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402

Query: 1569 KESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS--MVQAKADLQE 1626
            K  +      ++ELE LK ++   ++E        G +K  +  ++ S  M Q     Q 
Sbjct: 403  KRLQERCGLYKSELEILKEKLRQLKEE-----NNNGKEKLRIMAVKNSEVMAQLTESRQS 457

Query: 1627 ALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQV 1686
             L+L E+E+  K   +R+  SL+ E      EL V+++ +  +L L +QEIE     L+ 
Sbjct: 458  ILKL-ESELENKDEILRDKFSLMNE----NRELKVRVAAQNERLDLCQQEIESSRVELRS 512

Query: 1687 VLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL----EN 1742
            + + +S+   + +       L  +++     + D+ +   E  ++ + E +++L      
Sbjct: 513  LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 572

Query: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMTA----------------------------- 1773
            +Q++          Q  +   D +E  ++++                             
Sbjct: 573  IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY 632

Query: 1774 --ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNV 1831
              E + L + +E L  +   ++ +    +  +A         +E    + SN  KLE  +
Sbjct: 633  EKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEM 692

Query: 1832 RKLQQELDQLNR---DKLSLHNDISA----MQQQLQEKREAVNSLQEELANVQDHLNLA- 1883
             K   +L  L +   +K+  ++ I+A    ++Q+L EK E + SL+  +    + + LA 
Sbjct: 693  TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF 752

Query: 1884 -KQDLLHTTKH----------------QDVLLSEQTR----LQKDISEWANRFE------ 1916
             K   +H  +H                +D    EQ +    LQ+DI    +  E      
Sbjct: 753  EKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL 812

Query: 1917 -----DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE-------RESEESKL 1964
                 + +KE   K + L+ LQN++ E  +K+ Q +   +  ++E        E  + K 
Sbjct: 813  TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKF 872

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVL----AAEERVRTLQEEERWCESLEKTL 2020
            E       E+ + L+KEL  +   L +   + +      +++ + LQ+E      LE T 
Sbjct: 873  EKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQ 932

Query: 2021 SQTKRQLSEREQQLV---EKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
            ++ ++Q+S+ EQ+L    E S E L   +E     A  + L+ Q + E     +QV    
Sbjct: 933  TKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEM 992

Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNH---ERARRLMKELNQMQY--- 2131
            +  K + S++EK ++  K++       ++ ++++        E+    +KEL ++Q+   
Sbjct: 993  DQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE 1052

Query: 2132 -EYTE-LKKQMANQKDLERRQMEISDAMRTLKSEVKDEIR----------TSLKNLNQFL 2179
             E TE L+K+   + +L+    E+   +R L+ E++D ++          T++K+L   L
Sbjct: 1053 TELTEALQKREVLETELQNAHGELKSTLRQLQ-ELRDVLQKAQLSLEEKYTTIKDLTAEL 1111

Query: 2180 PELPADLE----AILERNENLEGELESLKE------NLPFTMNE--GPFEEK-------L 2220
             E   ++E     +LE ++ L+     LK+      +L  T+ E  G  E+K       L
Sbjct: 1112 RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTL 1171

Query: 2221 NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
              S++ + + + + E+L +KL++ +++L+ +    M +  + + + K++ E T   ++  
Sbjct: 1172 EKSELELKECNKQIESLNDKLQNAKEQLR-EKEFIMLQNEQEISQLKKEIERTQQRMKEM 1230

Query: 2281 VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
               + E     +     +  L Q E  LT + Q+  +  + A AR
Sbjct: 1231 ESVMKEQEQYIATQYKEAIDLGQ-ELRLTRE-QVQNSHTELAEAR 1273



 Score =  117 bits (293), Expect = 1e-25
 Identities = 179/844 (21%), Positives = 360/844 (42%), Gaps = 129/844 (15%)

Query: 266  RFSLEEVERLERDLEKKMIE-TEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEEL 324
            R  L ++E    DL+  M   T + +  Q   LE+  N  KL   + ++           
Sbjct: 647  RTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC---------- 696

Query: 325  KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
             S L T  + L++K +  +    K  ELEQEL       +    N   +E+ +I  A ++
Sbjct: 697  -SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNIN-TEHEKICLAFEK 754

Query: 385  SPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK 444
            +  I   ++K                 QI+++E   + +            D Q +++EK
Sbjct: 755  AKKIHLEQHKE-------------MEKQIERLEAQLEKK------------DQQFKEQEK 789

Query: 445  KISAAQTRLSELHDEIEKAEQQILRATEEFKQ----LEEAIQLKKISEAGKDLLYKQLSG 500
             +S  Q  +      +E  ++ +  +  E K+     +EA++  +   + + +  +QL  
Sbjct: 790  TMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDS 849

Query: 501  RLQL--------VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSH 552
             L++        +N+L       E Q++K+ +E+   QKE+K    ++     ++    H
Sbjct: 850  ALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQH 909

Query: 553  MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE--------TEEIKDLEEQLTEGQI 604
               Q+    QQ  I N + +  +++L++ +S++ +E         E+++ +EE+    + 
Sbjct: 910  TLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKC---ES 966

Query: 605  AANEA-LKK----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE 659
            AA+EA LK+    +L G    ++  +   K + ++ + E   L+ + E     L++++  
Sbjct: 967  AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026

Query: 660  RDQLEIVAMDAENMRKEL--------AELESALQEQHEVNASLQQTQGDLSAYEAELEAR 711
             DQ +       N  KEL         EL  ALQ++  +   LQ   G+L +   +L+  
Sbjct: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQEL 1086

Query: 712  LNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSEL 771
             ++       L+E+   +  LT  E    + E+E ++Q L   L   Q  +E+  E  + 
Sbjct: 1087 RDVLQKAQLSLEEKYTTIKDLT-AELRECKMEIEDKKQEL---LEMDQALKERNWELKQR 1142

Query: 772  HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHS 831
             A++ HL              + H   +   +++ E         + +L+L      I S
Sbjct: 1143 AAQVTHLD----------MTIREHRGEMEQKIIKLEGTLE-----KSELELKECNKQIES 1187

Query: 832  PSDVLGKSLADLQK------QFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE 885
             +D L  +   L++      Q  + +++ K E +  Q R ++++  M  Q++ +AT   +
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT---Q 1244

Query: 886  FRQACERALEARMNFDKRQH------EARIQQM--ENEIHYLQENLKSMEEIQGLTDLQL 937
            +++A +   E R+  ++ Q+      EAR QQ+  + EI  L   L+ M+++        
Sbjct: 1245 YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS------- 1297

Query: 938  QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAV---ATSDKLATAEL 994
            +E D     +  +L   + ++   +A+ Q ++  L  E++ LK+A      S +   A+ 
Sbjct: 1298 KEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKW 1357

Query: 995  TIAKDQLKSLHGTVMKINQ--ERAE-ELQEAERFSRKAAQAARDLTRAEAEIELLQNLLR 1051
             I+ D  KS   +V ++N+  E+A+ EL+EA+       Q  +D       IE     L 
Sbjct: 1358 KISADSQKS---SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEV---IEAANEALL 1411

Query: 1052 QKGE 1055
             KGE
Sbjct: 1412 TKGE 1415



 Score =  114 bits (284), Expect = 1e-24
 Identities = 209/1019 (20%), Positives = 419/1019 (41%), Gaps = 192/1019 (18%)

Query: 258  QDRQEAFERFSLEEVERLERDLEKKM----IETEELKSKQTRFLEEIKN-QDKL------ 306
            Q  +E  ER +L   E+  + L+++      E E LK K  +  EE  N ++KL      
Sbjct: 385  QAEEEILER-NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVK 443

Query: 307  NKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE 366
            N  +  +    +QS  +L+S+L  K+E+L+ K   +     ++ ++       ++D   +
Sbjct: 444  NSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNE--NRELKVRVAAQNERLDLCQQ 501

Query: 367  PLNYYPSEYAEIDKAPDESPYIGK--------SRYKRNMFAT-ESYIIDSAQA------- 410
             +     E   ++K   + P   +        S+Y+ + F+  E   I   +A       
Sbjct: 502  EIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE 561

Query: 411  VQIKKMEPDEQLRNDHMNLRGH-------TPLDTQLEDKEKKISAAQTRLS--------- 454
            ++IK    + +++  H NL  +       T  D+Q   K   +     +L          
Sbjct: 562  LRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVK 621

Query: 455  -----ELHDEIEKAEQQILRATEEFK----QLEEAIQLKKISEAGK----DLLYKQLSGR 501
                  ++ + EK  Q+++   EE +    Q+E      K++ A +     L+ ++L  +
Sbjct: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681

Query: 502  LQLVNKLRQE-------ALDLELQMEKQ--------------KQEIAGKQKEIKDLQIAI 540
                +KL  E        L LE Q+E++              +QE+  K ++I+ L+  I
Sbjct: 682  ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNI 741

Query: 541  DSLDSKD------------PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
            ++   K              +H  M+ Q    E QL+  ++Q+++ E  +  +   I  +
Sbjct: 742  NTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801

Query: 589  TEEIKDLEEQLTEGQ-IAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE-- 645
               ++ L+  LTE +     E +KKD         E L  ++ Q ++   + R+L     
Sbjct: 802  QHHLESLDRLLTESKGEMKKENMKKD---------EALKALQNQVSEETIKVRQLDSALE 852

Query: 646  --KETLLQRLTEVEQERD----QLEIVAMDAENMRKELAELESALQEQHEVNASLQQT-- 697
              KE L+  L ++E  ++    QL+  + +   ++KEL     +LQE  E N  LQ T  
Sbjct: 853  ICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ 912

Query: 698  ------------QGDLSAYEAELEARLNLRDAEANQLKE-ELEKVTRLTQLEQSALQAEL 744
                         G+L   + +LE +++  + E  + +E   EK+ ++ +  +SA   E 
Sbjct: 913  QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH-EA 971

Query: 745  EKERQALKNALGKAQ----FSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVV 800
            + +RQ +    G A+      ++ ++E S++  ++ HL+ D       L      L+   
Sbjct: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK 1031

Query: 801  DGLVRPEEVAARVDELRRKLK------------LGTGEMNIHSP-----------SDVLG 837
              L +       +++L+   +            L T   N H              DVL 
Sbjct: 1032 TELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQ 1091

Query: 838  KSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQE-KLATGQEEFRQACERALEA 896
            K+   L+++++ I   +   R+     E K QE + + Q  K    + + R A    L+ 
Sbjct: 1092 KAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDM 1151

Query: 897  RMNFDKRQHEARIQQMENEIHYLQENLKSM-EEIQGLTDLQLQEADE---EKERILAQLR 952
             +   + + E +I ++E  +   +  LK   ++I+ L D +LQ A E   EKE I+ Q  
Sbjct: 1152 TIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND-KLQNAKEQLREKEFIMLQNE 1210

Query: 953  ELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT---AELTIAKDQLKSLHGTVM 1009
            +   + K E  ++Q+++  ++  +K+ ++ +AT  K A     EL + ++Q+++ H  + 
Sbjct: 1211 QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELA 1270

Query: 1010 KINQERAEELQEAERFSRK----------------------AAQAARDL---TRAEAEIE 1044
            +   ++ +  +E ER S +                       A   R+     R +AEI+
Sbjct: 1271 EARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIK 1330

Query: 1045 LLQNLLRQKGEQFRLEM-----EKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVL 1098
             L   +    E + +EM             A+SQ   +++LNE +E+ + E+   Q+ +
Sbjct: 1331 KLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTV 1389



 Score =  108 bits (270), Expect = 6e-23
 Identities = 126/589 (21%), Positives = 283/589 (48%), Gaps = 78/589 (13%)

Query: 1329 EDIMQHLKSKK-REERWMRASKRQSE------KEMEELHHNIDDLLQEKKSLECEVEELH 1381
            E+++ HL   +  +E++ +  K++SE      KE++  +H++ +  ++   L+  +++  
Sbjct: 856  EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ- 914

Query: 1382 RTVQKRQQQKDFIDGNVESLMTELE-----IEKSL-KHHEDIVDEIECIEKTLLKRRSEL 1435
               Q+  QQ+   +G +E   T+LE     +E+ L K  E   +++  +E+   K  S  
Sbjct: 915  ---QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE---KCESAA 968

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
             EAD L  +   EL+ T  + K  ++++   K  L + E +   L+R  +  A++L + D
Sbjct: 969  HEAD-LKRQKVIELTGTARQVKIEMDQY---KEELSKMEKEIMHLKRDGENKAMHLSQLD 1024

Query: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
              L   + + +       K+   +KE+ K+  + +++     +K+E L  ELQ    +++
Sbjct: 1025 MILDQTKTELE-------KKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK 1077

Query: 1556 MAERNEDHHLQVLKESEVLLQAK-------RAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
               R       VL+++++ L+ K        AEL + K ++  ++QE+  +D+ L  +  
Sbjct: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137

Query: 1609 EL--------HL------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSF 1654
            EL        HL       +G M Q    L+  L   E E+ E CN  ++++SL ++L  
Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE-CN--KQIESLNDKLQN 1194

Query: 1655 QKGELNVQ---ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK----TELKNILDM--- 1704
             K +L  +   + + + +++ +K+EIE+ ++ ++ +   M + +    T+ K  +D+   
Sbjct: 1195 AKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254

Query: 1705 LQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERD 1764
            L+L   ++Q    +  +   +  + Q  +     ELE+++Q+S+++        + L   
Sbjct: 1255 LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314

Query: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNL 1824
            K  +     E+R +Q+ ++ LS E E L+E    +  ++   +   A  + ++  ++S++
Sbjct: 1315 K--VREAHLEAR-MQAEIKKLSAEVESLKEA---YHMEMISHQENHAKWKISADSQKSSV 1368

Query: 1825 EKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL 1873
            ++L   + K + EL++         + +S + QQ+Q++ E + +  E L
Sbjct: 1369 QQLNEQLEKAKLELEE-------AQDTVSNLHQQVQDRNEVIEAANEAL 1410



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 72/368 (19%), Positives = 172/368 (46%), Gaps = 26/368 (7%)

Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
            + L++    LKS  R+ + +R   ++++  +EE +  I DL  E +  + E+E+  + + 
Sbjct: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELL 1126

Query: 1386 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHE-DIVDEIECIEKTLLKRRSELREADRLLA 1443
            +  Q     +  ++    ++  ++ +++ H  ++  +I  +E TL K   EL+E ++ + 
Sbjct: 1127 EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIE 1186

Query: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 1503
                +L   KE+ +         ++ + Q + + E  ++R +E    + + +Q + +   
Sbjct: 1187 SLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYK 1246

Query: 1504 DAKDLEQH-KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
            +A DL Q  ++ +E++     ++  A+    Q   ++ E+L+ EL+ +++  +  + + +
Sbjct: 1247 EAIDLGQELRLTREQVQNSHTELAEARHQQVQA-QREIERLSSELEDMKQLSKEKDAHGN 1305

Query: 1563 H---HLQVLKESEVLLQAK-RAELEKLKSQVTSQQQ--EMAVLDRQLGHKKEELHLLQGS 1616
            H    L   K  E  L+A+ +AE++KL ++V S ++   M ++  Q  H K ++      
Sbjct: 1306 HLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKI------ 1359

Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
                 AD Q      ++ V +    + + K  LEE       L+ Q+ +R   +    + 
Sbjct: 1360 ----SADSQ------KSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409

Query: 1677 IEKEEENL 1684
            +  + EN+
Sbjct: 1410 LLTKGENV 1417



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 134/701 (19%), Positives = 288/701 (41%), Gaps = 101/701 (14%)

Query: 520  EKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLD 579
            +K     A   +EIK L+   + L+    +++ +  Q      + + ++ +  Q  +++ 
Sbjct: 218  DKMFSSSAPVDQEIKSLR---EKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVS 274

Query: 580  EILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
             +L    ++   +  LEEQ+   E +++A + + ++ E  +   Q+ +   +    +++ 
Sbjct: 275  -MLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333

Query: 638  ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE-VNASLQQ 696
            EC KL   K  LL++  + ++   Q      +AE + K   + +  + E+ E V A  + 
Sbjct: 334  ECIKL---KVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI 390

Query: 697  TQGDLSAYEAE---LEARLNLRDAEANQLKEELEKV----------TRLTQLEQSALQAE 743
             + +L+  E E   L+ R  L  +E   LKE+L ++           R+  ++ S + A+
Sbjct: 391  LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450

Query: 744  LEKERQALKNALGKAQFSEE-------KEQENSELHAKLKHLQDDNNLLKQQLKDFQ--- 793
            L + RQ++     + +  +E          EN EL  ++    +  +L +Q+++  +   
Sbjct: 451  LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL 510

Query: 794  NHLNHVVDGLVRPEEVAARVDEL----------RRKLKLGTGEMNIHSPSDV---LGKSL 840
              L  ++  L    E+      L          +    +G  E N    S++   L    
Sbjct: 511  RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE 570

Query: 841  ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
            A++QK  + + A    +        ++  +  +L+ E +  G  +  ++ +   +  MN 
Sbjct: 571  AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMN- 629

Query: 901  DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK---- 956
              +Q+E   Q++   I  L+  L  +E     +DL++  A    +  L Q   LEK    
Sbjct: 630  --KQYEKERQRLVTGIEELRTKLIQIEAEN--SDLKVNMAHRTSQFQLIQEELLEKASNS 685

Query: 957  -KKKLEDAKSQEQVFGLDKELKK---LKKAVATSDKLATAELTIAKDQLKSLHGTV---- 1008
             K + E  K   Q+  L+K+L++      ++A  +     EL    ++++SL   +    
Sbjct: 686  SKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEH 745

Query: 1009 ----------MKINQERAEELQ-EAERFSRKAAQAARDLTRAEAEIELLQN--------- 1048
                       KI+ E+ +E++ + ER   +  +  +     E  + +LQ          
Sbjct: 746  EKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHL 805

Query: 1049 ------LLRQKGEQFRLEMEKTGVGTGANSQV----LEIEKLNETMERQRTEIARLQNVL 1098
                  L   KGE  +  M+K        +QV    +++ +L+  +E  + E+    N L
Sbjct: 806  ESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL 865

Query: 1099 DLTGSDNKGGFENVL----EEIAELRREVSYQNDYISSMAD 1135
            +     NK  FE  L    EE+  L++E+  +N  +   ++
Sbjct: 866  E----GNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 902



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 81/388 (20%), Positives = 160/388 (41%), Gaps = 45/388 (11%)

Query: 764  KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKL- 822
            K+ E   L A +  L+ +  + +  L+     L+ V      P E +       R  KL 
Sbjct: 129  KDNEEESLLANVASLRHELKITEWSLQSLGEELSSV-----SPSENSDYAPNPSRSEKLI 183

Query: 823  ------GTGEMNIHSPSDVLGK---SLADLQKQFSEILARSKWERDEAQVRERKLQEEMA 873
                    G +N +SP + + K   S  D QK+  + +  S    D+     R+   ++ 
Sbjct: 184  LDVQPSHPGLLN-YSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLR 242

Query: 874  LQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN------EIHYLQENLKSME 927
             Q   L T         E      ++F+  Q  A++  +E+       +  L+E + ++E
Sbjct: 243  QQNACLVTQNHSLMTKFES-----IHFELTQSRAKVSMLESAQQQAASVPILEEQIINLE 297

Query: 928  EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
                  D  L+EA+ + E+  +Q   +EK++ L+++K  E+   L  +L +  K    ++
Sbjct: 298  AEVSAQDKVLREAENKLEQ--SQKMVIEKEQSLQESK--EECIKLKVDLLEQTKQGKRAE 353

Query: 988  KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE------- 1040
            +     L  A++  K+      K+ ++  +   E E   R      ++  R +       
Sbjct: 354  RQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYK 413

Query: 1041 AEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDL 1100
            +E+E+L+  LRQ  E+     EK  +    NS+V+        +   R  I +L++ L+ 
Sbjct: 414  SELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVM------AQLTESRQSILKLESELEN 467

Query: 1101 TGSDNKGGFENVLEEIAELRREVSYQND 1128
                 +  F +++ E  EL+  V+ QN+
Sbjct: 468  KDEILRDKF-SLMNENRELKVRVAAQNE 494


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  157 bits (396), Expect = 1e-37
 Identities = 223/1044 (21%), Positives = 430/1044 (41%), Gaps = 144/1044 (13%)

Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE--------- 1374
            +V+R ++++Q   ++ +E + ++  ++QS +E+ EL   +  L +E+  L          
Sbjct: 871  QVTRQDEVLQ---ARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 927

Query: 1375 -CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
              E EE    +  R+Q+ + +           E+E  +   E+   +++  +K L +   
Sbjct: 928  CAEAEETRGRLAARKQELELVVS---------ELEARVGEEEECSRQMQTEKKRLQQHIQ 978

Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
            EL         A  +L   K  T+  ++KF   +  LL  E    +L +  +     L +
Sbjct: 979  ELEAHLEAEEGARQKLQLEKVTTEAKMKKF---EEDLLLLEDQNSKLSKERKLLEDRLAE 1035

Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
               Q    +   K L + ++K E           A  +D +   +K+EK  +EL+KL++ 
Sbjct: 1036 FSSQAAEEEEKVKSLNKLRLKYE-----------ATIADMEDRLRKEEKGRQELEKLKRR 1084

Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL- 1612
            ++                         E  +L+ Q+  QQQ    L  QLG K+EEL   
Sbjct: 1085 LD------------------------GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA 1120

Query: 1613 -------------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
                         L  S+ +A+A L EA    E+E   +    ++ + L EEL   +GEL
Sbjct: 1121 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1180

Query: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQ 1718
               +     Q     QE+  + E          +  TELK  L +  ++    +Q L+ +
Sbjct: 1181 EDTLDSTNAQ-----QELRSKRE----------QEVTELKKTLEEETRIHEAAVQELRQR 1225

Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
            H Q + EL                 +Q+ Q ++G+  W+K  L  +  E+  + AE  +L
Sbjct: 1226 HGQALGEL----------------AEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1268

Query: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
            Q+  +   + +  L+ +    + +    +R  A A E  +  Q+ LE +   + + + + 
Sbjct: 1269 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328

Query: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
             +L+++  S    +   Q+ LQE+  A  +L   +  ++      ++ L      ++   
Sbjct: 1329 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAG 1388

Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
             E    Q  +SEW  R E+     E  ++  +    E E    +L ++     RL++ R 
Sbjct: 1389 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1448

Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCE 2014
              + +L+ + + L EQQ QL   L  ++ K DQ+L++  AA   +R ++E ER      E
Sbjct: 1449 RLQQELDDATMDL-EQQRQLVSTLEKKQRKFDQLLAEEKAAV--LRAVEERERAEAEGRE 1505

Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
               + LS T+    E EQ+  E+      L+++  ++RA+   L    L+ +    K V 
Sbjct: 1506 REARALSLTR--ALEEEQEAREE------LERQNRALRAELEAL----LSSKDDVGKSVH 1553

Query: 2075 SLKEALKIQR---SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQ 2128
             L+ A ++     + L   + E + E +  +     +E+  Q     HER  +   E  +
Sbjct: 1554 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1613

Query: 2129 MQYEYTELKKQMAN---QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
             +    +L KQ+ +   ++D ER+Q  ++ A R       +E++  + +  Q   E    
Sbjct: 1614 ERRR--QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1671

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKL 2241
            L  +  + + L  E+E  + +     ++    EK    L    + + +E    +  R + 
Sbjct: 1672 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1731

Query: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
            +   D +  ++ +    +A +L + KRQ EG L  L  +++   E   S   +      L
Sbjct: 1732 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEE--EQSNSELLNDRYRKLL 1788

Query: 2302 SQLESSLTEDSQLGQNQEKNASAR 2325
             Q+ES  TE S       K  S R
Sbjct: 1789 LQVESLTTELSAERSFSAKAESGR 1812



 Score =  145 bits (367), Expect = 3e-34
 Identities = 220/1036 (21%), Positives = 441/1036 (42%), Gaps = 139/1036 (13%)

Query: 1368 QEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIE 1422
            ++ + L+   +EL + VQ+ QQQ     G ++  + +LE E++     L+   ++  E E
Sbjct: 874  RQDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 932

Query: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
                 L  R+ EL   + +++E E+ +   +E ++    +    ++ + + E+  E  E 
Sbjct: 933  ETRGRLAARKQEL---ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 989

Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
              Q+  +  V  + +++  + D   LE    K    L +  K++  + ++F   + ++E+
Sbjct: 990  ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK----LSKERKLLEDRLAEFSSQAAEEEE 1045

Query: 1543 LTEELQKLQ-------KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
              + L KL+        D+E   R E+   Q L++ +  L  + +EL++   Q+  QQQ 
Sbjct: 1046 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQR 1102

Query: 1596 MAVLDRQLGHKKEELHL--------------LQGSMVQAKADLQEALRLGETEVTEKCNH 1641
               L  QLG K+EEL                L  S+ +A+A L EA    E+E   +   
Sbjct: 1103 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1162

Query: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
             ++ + L EEL   +GEL   +     Q     QE+  + E          +  TELK  
Sbjct: 1163 EKQRRDLGEELEALRGELEDTLDSTNAQ-----QELRSKRE----------QEVTELKKT 1207

Query: 1702 LDM-LQLENHELQGLKLQHDQRVSEL--------------EKTQVA----VLEEKLELEN 1742
            L+   ++    +Q L+ +H Q + EL              EKT++A    V E + EL +
Sbjct: 1208 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1267

Query: 1743 LQ---QISQQQKGEIEWQKQ------------------LLERDKREIERMTAESRALQSC 1781
            LQ   Q  +Q++  +E Q Q                   L+R + E+E ++      +S 
Sbjct: 1268 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1327

Query: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
               LSKE    + +    ++ L +  R   A     +  ++    L   + +     ++ 
Sbjct: 1328 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1387

Query: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
             R+  +    +S  +++ +E+  A+ + +E             Q L   T+  D L   +
Sbjct: 1388 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1447

Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
             RLQ+++ +     E  ++   T +++ +     + E K  +++     +R + E    E
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507

Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV-RTLQEEERWCESLEKTL 2020
            ++  +    L+E+Q +  +EL  Q   L   L  +L++++ V +++ E ER C   E+  
Sbjct: 1508 ARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA 1566

Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRA----DFSLLRNQFLTERKKAEKQVASL 2076
            +  + Q++E E +L       L L+    +++     D           R++  KQ+   
Sbjct: 1567 NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA 1626

Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
            +     +R Q    +  +K+    +++  A +    Q   E  ++L K   QM+  + E+
Sbjct: 1627 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1686

Query: 2137 KKQMANQKDLERRQMEISDAMRTLKSEV---KDEIRTS---LKNLNQFLPELPADL---- 2186
            ++   +++++  +  E    ++ L++EV   ++E+  S    +   Q   E+  ++    
Sbjct: 1687 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1746

Query: 2187 ---EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRH 2243
                AILE    LEG L  L+E L         EE+ + S+  ++++ +R      KL  
Sbjct: 1747 LSKAAILEEKRQLEGRLGQLEEEL---------EEEQSNSE--LLNDRYR------KLLL 1789

Query: 2244 REDRLKAQL--RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
            + + L  +L      S +AE    G++Q E  +  LR +   LGE      A +    ++
Sbjct: 1790 QVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGR---LGE--EDAGARARHKMTI 1841

Query: 2302 SQLESSLTE-DSQLGQ 2316
            + LES L + + QL Q
Sbjct: 1842 AALESKLAQAEEQLEQ 1857



 Score =  116 bits (290), Expect = 3e-25
 Identities = 203/951 (21%), Positives = 386/951 (40%), Gaps = 131/951 (13%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            ++  L  E   LED +    S+  EE     S  +   + E    +++D L++++    E
Sbjct: 1018 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1077

Query: 1377 VEELHRTVQ----KRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
            +E+L R +     + Q+Q        E L  +L     E++ +L   ED           
Sbjct: 1078 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA----RAQ 1133

Query: 1428 LLKRRSELREADRLLAEAESELSCTK------EKTKNAVEKFTDAKRSLLQTESDA---- 1477
            LLK    LREA   LAEA+ +L   +      EK +  + +  +A R  L+   D+    
Sbjct: 1134 LLK---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1190

Query: 1478 EELERRAQETAVNLVKA-DQQLRSLQADAKDLEQHKIKQ----EEILKEINKIVAAKDSD 1532
            +EL  + ++    L K  +++ R  +A  ++L Q   +      E L++  +   A +  
Sbjct: 1191 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1250

Query: 1533 FQCLSKKKEKLTEELQKLQ---KDIEMAERNEDHHLQVLK-----------ESEVLLQAK 1578
               L  +  +L  EL  LQ   ++ E   R  +  LQ ++           E+   LQ  
Sbjct: 1251 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1310

Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEV 1635
            +AELE +   +   + +   L ++L   + +LH  Q  +    +AK  L   +R  E E 
Sbjct: 1311 QAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEA 1370

Query: 1636 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ---MS 1692
                  + E  +  E    +      Q+SE + +       +E  EE  +   R+   ++
Sbjct: 1371 AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALT 1430

Query: 1693 KHKTELKNILDMLQLENHELQG------LKL-QHDQRVSELEKTQ----VAVLEEKLELE 1741
            +   E    +D L+     LQ       + L Q  Q VS LEK Q      + EEK  + 
Sbjct: 1431 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV- 1489

Query: 1742 NLQQISQQQKGEIEWQKQ---------LLERDKREIERMTAESRALQSCVECLSKEKED- 1791
             L+ + ++++ E E +++          LE ++   E +  ++RAL++ +E L   K+D 
Sbjct: 1490 -LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1548

Query: 1792 ------LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR--KLQQELDQLNR 1843
                  L+  C + E+     +  +   E+     +    +LE+ V+  K Q E D   R
Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608

Query: 1844 DKLS------LHNDISAMQQQLQEKRE-------AVNSLQEELANVQDHLNLAKQDLLHT 1890
            D+        L   +   + +  E+R+       A   L+ EL  ++  +  A Q     
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668

Query: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
             K    + ++   L +++ E     E+   +    +++L+ L+ E+   + +L   +   
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728

Query: 1951 QRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSK-----------V 1996
            ++ Q++R+    E +    SK  + E++ QLE  L   + +L++  S            +
Sbjct: 1729 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1788

Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK------EADS 2050
            L  E     L  E  +    E    Q +RQ+ E   +L E+     A  K      E+  
Sbjct: 1789 LQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKL 1848

Query: 2051 MRADFSL---LRNQFLTER--KKAEKQ----VASLKEALKIQ---RSQLEKNLLEQKQEN 2098
             +A+  L    R + L+ +  ++AEK+    V  ++E  ++    R QLEK  L  KQ  
Sbjct: 1849 AQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ-- 1906

Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
              +++++   E  A       RRL +EL  +      + +++   ++  RR
Sbjct: 1907 --LKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955



 Score =  113 bits (282), Expect = 2e-24
 Identities = 176/868 (20%), Positives = 361/868 (41%), Gaps = 136/868 (15%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL------QEKKSL 1373
            +L    + L +  + L+S++         +R   +E+E L   ++D L      QE +S 
Sbjct: 1137 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1196

Query: 1374 -ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKR 1431
             E EV EL +T+++            E+ + E  +++  + H   + E+ E +E+   +R
Sbjct: 1197 REQEVTELKKTLEE------------ETRIHEAAVQELRQRHGQALGELAEQLEQA--RR 1242

Query: 1432 RSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
                 E  RL  EAE     +ELS  +   +   ++    +  L + +  A + ER   E
Sbjct: 1243 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1302

Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIK--------------QEEILKEINKIVAAKDSD 1532
             A  L +A  +L ++     + E   I+               +E+L+E  +   A  S 
Sbjct: 1303 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1362

Query: 1533 FQCLSKK--------------KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
             + +  +              +E+   ELQ  Q  +    R ++     L+  E   +  
Sbjct: 1363 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1422

Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
              E E L  ++  + + +  L+R  G ++     LQ  +  A  DL++  +L  T   ++
Sbjct: 1423 AREAEALTQRLAEKTETVDRLER--GRRR-----LQQELDDATMDLEQQRQLVSTLEKKQ 1475

Query: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
                  + E K+ +     ++     +  ER+ +   + + +E+E+E  + + RQ    +
Sbjct: 1476 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1535

Query: 1696 TELKNIL---DMLQLENHELQGLKLQHDQ-------RVSELEKTQVAVLEEKLELE-NLQ 1744
             EL+ +L   D +    HEL+      +Q       +V+ELE    A  + KL LE  +Q
Sbjct: 1536 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1595

Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK-- 1802
             +  Q + +++ + +  E  +R++ +   ++         + +++E  Q    +  +K  
Sbjct: 1596 ALKTQHERDLQGRDEAGEERRRQLAKQLRDAE--------VERDEERKQRTLAVAARKKL 1647

Query: 1803 ---LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
               L + K  +A+A +  +     L K++  +++L +E+++    +  + +     +++L
Sbjct: 1648 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1707

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDISEWA 1912
            +     V  LQEELA        A+QD       + +    +  +L E+ +L+  + +  
Sbjct: 1708 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1767

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
               E+ Q   E    + + L  ++E    +L  +     + +  R+  E +++  +  L 
Sbjct: 1768 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1827

Query: 1973 EQ------QHQ-----LEKELTDQKSKLDQ-----VLSKVLA--AEERVRTL----QEEE 2010
            E+      +H+     LE +L   + +L+Q     +LS  L   AE+R++ +    +EE 
Sbjct: 1828 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1887

Query: 2011 RWCESLEKTLS-------QTKRQLSEREQQLVEKSGELLALQKE-------ADSMRADFS 2056
            R  + L   L        Q KRQL E E++          LQ+E       A+SM  + +
Sbjct: 1888 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1947

Query: 2057 LLRNQF----LTERKKAEKQVASLKEAL 2080
             LRN+     LT   +  +QV  L+E +
Sbjct: 1948 TLRNRLRRGPLTFTTRTVRQVFRLEEGV 1975



 Score =  107 bits (267), Expect = 1e-22
 Identities = 198/959 (20%), Positives = 406/959 (42%), Gaps = 110/959 (11%)

Query: 255  VTTQDRQEAFERFSLEEVERLERDLEKKMIETE----ELKSKQTRFLEEIKNQDKLNKSL 310
            VT QD         L++V+ L++   +++ E +    +L+ ++ R  E+++ + +L    
Sbjct: 872  VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 931

Query: 311  KE---EAMLQKQSCE----ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
            +E       +KQ  E    EL++ +  + E  +Q   E  R  Q   ELE  L   +   
Sbjct: 932  EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 991

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            +   L    +E A++ K  ++   +     K  +      + D       +  E +E+++
Sbjct: 992  QKLQLEKVTTE-AKMKKFEEDLLLLEDQNSK--LSKERKLLEDRLAEFSSQAAEEEEKVK 1048

Query: 424  NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
            + +     +      +ED+ +K    +  L +L   ++    ++     E +Q  E ++ 
Sbjct: 1049 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108

Query: 484  ---KKISEAGKDLLYKQLSG--RLQLVNKLRQ-EALDLELQMEKQKQEIAGK--QKEIKD 535
               +K  E    L   +  G  R QL+  LR+ +A   E Q + + + +A    +K+ +D
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1168

Query: 536  LQIAIDSL-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL----ESRLDEILSRIA 586
            L   +++L     D+ D  ++  +  +S +EQ++  + K  ++     E+ + E+  R  
Sbjct: 1169 LGEELEALRGELEDTLDSTNAQQEL-RSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227

Query: 587  KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
            +   E+ +  EQ   G+  A E  +  LE  +S L+  L +++    + +   R+L  + 
Sbjct: 1228 QALGELAEQLEQARRGK-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1286

Query: 647  ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
            + +  R  + E+ R      A  AE +++  AELE+     +E  +   +   +LS+ EA
Sbjct: 1287 QEVQGRAGDGERAR------AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1340

Query: 707  ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA-----LGKAQFS 761
            +L     L   E  + K  L    R  + E + L+ +LE+E  A + A       +AQ S
Sbjct: 1341 QLHDAQELLQEET-RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1399

Query: 762  EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
            E + ++  E  A    L+      ++  ++ +     +   L    E   R++  RR+L+
Sbjct: 1400 EWRRRQEEEAGA----LEAGEEARRRAAREAEA----LTQRLAEKTETVDRLERGRRRLQ 1451

Query: 822  --LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---------ERDEAQVRERKLQ- 869
              L    M++     ++  +L   Q++F ++LA  K          ER EA+ RER+ + 
Sbjct: 1452 QELDDATMDLEQQRQLVS-TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1510

Query: 870  -------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE---------------- 906
                   EE    +E+L       R   E  L ++ +  K  HE                
Sbjct: 1511 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1570

Query: 907  ARIQQMENEIHYLQENLKSME------EIQGLTDLQ-LQEADEEKERILA-QLRELE--- 955
            A++ ++E+E+   ++    +E      + Q   DLQ   EA EE+ R LA QLR+ E   
Sbjct: 1571 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1630

Query: 956  ---KKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
               +K++     +++++ G  +ELK    +     + A  +L   + Q+K L   V +  
Sbjct: 1631 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1690

Query: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-EKTGVGTGAN 1071
              R E   +     ++      ++ R + E+    +  R++ +Q R EM ++   G  + 
Sbjct: 1691 TSREEIFSQNRESEKRLKGLEAEVLRLQEEL-AASDRARRQAQQDRDEMADEVANGNLSK 1749

Query: 1072 SQVLEIEK-LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
            + +LE ++ L   + +   E+   Q+  +L        +  +L ++  L  E+S +  +
Sbjct: 1750 AAILEEKRQLEGRLGQLEEELEEEQSNSELLND----RYRKLLLQVESLTTELSAERSF 1804



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 180/860 (20%), Positives = 350/860 (40%), Gaps = 133/860 (15%)

Query: 247  LESLEGQPVTTQDRQEAFERFSL---EEVERLERDLEKKM----IETEELKSKQTRFLEE 299
            LE+L G+   T D   A +       +EV  L++ LE++        +EL+ +  + L E
Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1232

Query: 300  IKNQ---DKLNKSLKEEAMLQKQS-CEELKSDLNTKNELLKQKTIELTRACQKQYELEQE 355
            +  Q    +  K   E+  L  ++   EL+++L++  +  +Q+  +  R  + Q +  Q 
Sbjct: 1233 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL-QTARQEGEQRRRRLELQLQEVQG 1291

Query: 356  LAFYKIDAKFEPLNYYPSEYAEIDKAPD-----ESPYIGKSRYKRNMFATESYIIDSAQA 410
             A     A+ E         AE++         ES  I   R  + + +TE+ + D+ + 
Sbjct: 1292 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI---RLSKELSSTEAQLHDAQEL 1348

Query: 411  VQIK---KMEPDEQLRNDHMNLRGHTPLDTQLEDKE-------KKISAAQTRLSELHDE- 459
            +Q +   K+    ++R       G   L  QLE++        +++  AQ +LSE     
Sbjct: 1349 LQEETRAKLALGSRVRAMEAEAAG---LREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1405

Query: 460  ------IEKAEQQILRATEEFKQLEEAIQLKKIS----EAGKDLLYKQLSG-------RL 502
                  +E  E+   RA  E + L + +  K  +    E G+  L ++L         + 
Sbjct: 1406 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1465

Query: 503  QLVNKLR------------QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
            QLV+ L             ++A  L    E+++ E  G+++E + L +   +L+ +    
Sbjct: 1466 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT-RALEEEQEAR 1524

Query: 551  SHMKAQKSGKEQQLDIMNKQYQQLESRLDEI--LSRIAKETE-----EIKDLEEQLTEGQ 603
              ++ Q      +L+ +      +   + E+    R+A++       ++ +LE++LT  +
Sbjct: 1525 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1584

Query: 604  IA------ANEALK----KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
             A        +ALK    +DL+G     +E    +  Q   A+ E  + R ++   +   
Sbjct: 1585 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1644

Query: 654  TEVEQERDQLEIVAMDA----ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
             ++E E ++L+     A    E   K+L ++++ ++E        + ++ ++ +   E E
Sbjct: 1645 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1704

Query: 710  ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ--- 766
             RL   +AE  +L+EEL    R     + A Q   E   +     L KA   EEK Q   
Sbjct: 1705 KRLKGLEAEVLRLQEELAASDR---ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1761

Query: 767  ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
               +L  +L+  Q ++ LL  + +     +  +   L      +A+ +  R++       
Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ------- 1814

Query: 827  MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
                            L++Q  E+  R   E   A+ R +     +A  + KLA  +E+ 
Sbjct: 1815 ----------------LERQIQELRGRLGEEDAGARARHKM---TIAALESKLAQAEEQL 1855

Query: 887  RQAC-ERALEARM--NFDKRQHEARIQQMENE--IHYLQENLKSMEEIQGLTDLQLQEAD 941
             Q   ER L  ++    +KR  E  +Q  E       L++ L+           QL+EA+
Sbjct: 1856 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1915

Query: 942  EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
            EE  R  A  R L+  ++LED    E    +++E+  L+      ++L    LT     +
Sbjct: 1916 EEASRAQAGRRRLQ--RELEDV--TESAESMNREVTTLR------NRLRRGPLTFTTRTV 1965

Query: 1002 KSLHGTVMKI-NQERAEELQ 1020
            + +      + + E AEE Q
Sbjct: 1966 RQVFRLEEGVASDEEAEEAQ 1985



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 121/654 (18%), Positives = 273/654 (41%), Gaps = 69/654 (10%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD--LLQEKKSLECEVE 1378
            L +  ++L D  + L+ + R +  + +  R  E E   L   +++    +E+   E +  
Sbjct: 1335 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1394

Query: 1379 ELHRTVQKRQQQKD---FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
            +   +  +R+Q+++      G         E E   +   +  + ++ +E+   + + EL
Sbjct: 1395 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1454

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET---AVNLV 1492
             +A   L +    +S  ++K +   +   + K ++L+   + E  E   +E    A++L 
Sbjct: 1455 DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1514

Query: 1493 KA-----------DQQLRSLQADAKDLEQHKIKQEEILKEINKIV-----AAKDSDFQCL 1536
            +A           ++Q R+L+A+ + L   K    + + E+ +       AA D   Q  
Sbjct: 1515 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1574

Query: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE- 1595
              + E    E  KL+ ++ +      H   +    E   + +R   ++L+     + +E 
Sbjct: 1575 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1634

Query: 1596 ----MAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
                +AV  R+ L  + EEL     S  Q K +  + LR  + ++ E    + E ++  E
Sbjct: 1635 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1694

Query: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN-------ILD 1703
            E+  Q  E   ++   + ++  +++E+   +   +   +   +   E+ N       IL+
Sbjct: 1695 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1754

Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK-----LELENLQ-QISQQQK--GEIE 1755
                E  +L+G   Q ++ + E E++   +L ++     L++E+L  ++S ++    + E
Sbjct: 1755 ----EKRQLEGRLGQLEEELEE-EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1809

Query: 1756 WQKQLLERDKREIERMTAESRA---------LQSCVECLSKEKEDLQEKCD--IWEKKLA 1804
              +Q LER  +E+     E  A         + +    L++ +E L+++    I   KL 
Sbjct: 1810 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1869

Query: 1805 QT-----KRVLAAAEENSKME---QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
            +      K V+   EE  ++    +  LEK  L V++L+++L++   +          +Q
Sbjct: 1870 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1929

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
            ++L++  E+  S+  E+  +++ L          T  Q   L E     ++  E
Sbjct: 1930 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1983


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  157 bits (396), Expect = 1e-37
 Identities = 223/1044 (21%), Positives = 430/1044 (41%), Gaps = 144/1044 (13%)

Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE--------- 1374
            +V+R ++++Q   ++ +E + ++  ++QS +E+ EL   +  L +E+  L          
Sbjct: 863  QVTRQDEVLQ---ARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 919

Query: 1375 -CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
              E EE    +  R+Q+ + +           E+E  +   E+   +++  +K L +   
Sbjct: 920  CAEAEETRGRLAARKQELELVVS---------ELEARVGEEEECSRQMQTEKKRLQQHIQ 970

Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
            EL         A  +L   K  T+  ++KF   +  LL  E    +L +  +     L +
Sbjct: 971  ELEAHLEAEEGARQKLQLEKVTTEAKMKKF---EEDLLLLEDQNSKLSKERKLLEDRLAE 1027

Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
               Q    +   K L + ++K E           A  +D +   +K+EK  +EL+KL++ 
Sbjct: 1028 FSSQAAEEEEKVKSLNKLRLKYE-----------ATIADMEDRLRKEEKGRQELEKLKRR 1076

Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL- 1612
            ++                         E  +L+ Q+  QQQ    L  QLG K+EEL   
Sbjct: 1077 LD------------------------GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA 1112

Query: 1613 -------------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
                         L  S+ +A+A L EA    E+E   +    ++ + L EEL   +GEL
Sbjct: 1113 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1172

Query: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQ 1718
               +     Q     QE+  + E          +  TELK  L +  ++    +Q L+ +
Sbjct: 1173 EDTLDSTNAQ-----QELRSKRE----------QEVTELKKTLEEETRIHEAAVQELRQR 1217

Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
            H Q + EL                 +Q+ Q ++G+  W+K  L  +  E+  + AE  +L
Sbjct: 1218 HGQALGEL----------------AEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1260

Query: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
            Q+  +   + +  L+ +    + +    +R  A A E  +  Q+ LE +   + + + + 
Sbjct: 1261 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320

Query: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
             +L+++  S    +   Q+ LQE+  A  +L   +  ++      ++ L      ++   
Sbjct: 1321 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAG 1380

Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
             E    Q  +SEW  R E+     E  ++  +    E E    +L ++     RL++ R 
Sbjct: 1381 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1440

Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCE 2014
              + +L+ + + L EQQ QL   L  ++ K DQ+L++  AA   +R ++E ER      E
Sbjct: 1441 RLQQELDDATMDL-EQQRQLVSTLEKKQRKFDQLLAEEKAAV--LRAVEERERAEAEGRE 1497

Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
               + LS T+    E EQ+  E+      L+++  ++RA+   L    L+ +    K V 
Sbjct: 1498 REARALSLTR--ALEEEQEAREE------LERQNRALRAELEAL----LSSKDDVGKSVH 1545

Query: 2075 SLKEALKIQR---SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQ 2128
             L+ A ++     + L   + E + E +  +     +E+  Q     HER  +   E  +
Sbjct: 1546 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1605

Query: 2129 MQYEYTELKKQMAN---QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
             +    +L KQ+ +   ++D ER+Q  ++ A R       +E++  + +  Q   E    
Sbjct: 1606 ERRR--QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1663

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKL 2241
            L  +  + + L  E+E  + +     ++    EK    L    + + +E    +  R + 
Sbjct: 1664 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1723

Query: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
            +   D +  ++ +    +A +L + KRQ EG L  L  +++   E   S   +      L
Sbjct: 1724 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEE--EQSNSELLNDRYRKLL 1780

Query: 2302 SQLESSLTEDSQLGQNQEKNASAR 2325
             Q+ES  TE S       K  S R
Sbjct: 1781 LQVESLTTELSAERSFSAKAESGR 1804



 Score =  145 bits (367), Expect = 3e-34
 Identities = 220/1036 (21%), Positives = 441/1036 (42%), Gaps = 139/1036 (13%)

Query: 1368 QEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIE 1422
            ++ + L+   +EL + VQ+ QQQ     G ++  + +LE E++     L+   ++  E E
Sbjct: 866  RQDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 924

Query: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
                 L  R+ EL   + +++E E+ +   +E ++    +    ++ + + E+  E  E 
Sbjct: 925  ETRGRLAARKQEL---ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 981

Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
              Q+  +  V  + +++  + D   LE    K    L +  K++  + ++F   + ++E+
Sbjct: 982  ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK----LSKERKLLEDRLAEFSSQAAEEEE 1037

Query: 1543 LTEELQKLQ-------KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
              + L KL+        D+E   R E+   Q L++ +  L  + +EL++   Q+  QQQ 
Sbjct: 1038 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQR 1094

Query: 1596 MAVLDRQLGHKKEELHL--------------LQGSMVQAKADLQEALRLGETEVTEKCNH 1641
               L  QLG K+EEL                L  S+ +A+A L EA    E+E   +   
Sbjct: 1095 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1154

Query: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
             ++ + L EEL   +GEL   +     Q     QE+  + E          +  TELK  
Sbjct: 1155 EKQRRDLGEELEALRGELEDTLDSTNAQ-----QELRSKRE----------QEVTELKKT 1199

Query: 1702 LDM-LQLENHELQGLKLQHDQRVSEL--------------EKTQVA----VLEEKLELEN 1742
            L+   ++    +Q L+ +H Q + EL              EKT++A    V E + EL +
Sbjct: 1200 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1259

Query: 1743 LQ---QISQQQKGEIEWQKQ------------------LLERDKREIERMTAESRALQSC 1781
            LQ   Q  +Q++  +E Q Q                   L+R + E+E ++      +S 
Sbjct: 1260 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1319

Query: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
               LSKE    + +    ++ L +  R   A     +  ++    L   + +     ++ 
Sbjct: 1320 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1379

Query: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
             R+  +    +S  +++ +E+  A+ + +E             Q L   T+  D L   +
Sbjct: 1380 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1439

Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
             RLQ+++ +     E  ++   T +++ +     + E K  +++     +R + E    E
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499

Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV-RTLQEEERWCESLEKTL 2020
            ++  +    L+E+Q +  +EL  Q   L   L  +L++++ V +++ E ER C   E+  
Sbjct: 1500 ARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA 1558

Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRA----DFSLLRNQFLTERKKAEKQVASL 2076
            +  + Q++E E +L       L L+    +++     D           R++  KQ+   
Sbjct: 1559 NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA 1618

Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
            +     +R Q    +  +K+    +++  A +    Q   E  ++L K   QM+  + E+
Sbjct: 1619 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1678

Query: 2137 KKQMANQKDLERRQMEISDAMRTLKSEV---KDEIRTS---LKNLNQFLPELPADL---- 2186
            ++   +++++  +  E    ++ L++EV   ++E+  S    +   Q   E+  ++    
Sbjct: 1679 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1738

Query: 2187 ---EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRH 2243
                AILE    LEG L  L+E L         EE+ + S+  ++++ +R      KL  
Sbjct: 1739 LSKAAILEEKRQLEGRLGQLEEEL---------EEEQSNSE--LLNDRYR------KLLL 1781

Query: 2244 REDRLKAQL--RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
            + + L  +L      S +AE    G++Q E  +  LR +   LGE      A +    ++
Sbjct: 1782 QVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGR---LGE--EDAGARARHKMTI 1833

Query: 2302 SQLESSLTE-DSQLGQ 2316
            + LES L + + QL Q
Sbjct: 1834 AALESKLAQAEEQLEQ 1849



 Score =  116 bits (290), Expect = 3e-25
 Identities = 203/951 (21%), Positives = 386/951 (40%), Gaps = 131/951 (13%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            ++  L  E   LED +    S+  EE     S  +   + E    +++D L++++    E
Sbjct: 1010 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1069

Query: 1377 VEELHRTVQ----KRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
            +E+L R +     + Q+Q        E L  +L     E++ +L   ED           
Sbjct: 1070 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA----RAQ 1125

Query: 1428 LLKRRSELREADRLLAEAESELSCTK------EKTKNAVEKFTDAKRSLLQTESDA---- 1477
            LLK    LREA   LAEA+ +L   +      EK +  + +  +A R  L+   D+    
Sbjct: 1126 LLK---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1182

Query: 1478 EELERRAQETAVNLVKA-DQQLRSLQADAKDLEQHKIKQ----EEILKEINKIVAAKDSD 1532
            +EL  + ++    L K  +++ R  +A  ++L Q   +      E L++  +   A +  
Sbjct: 1183 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1242

Query: 1533 FQCLSKKKEKLTEELQKLQ---KDIEMAERNEDHHLQVLK-----------ESEVLLQAK 1578
               L  +  +L  EL  LQ   ++ E   R  +  LQ ++           E+   LQ  
Sbjct: 1243 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1302

Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEV 1635
            +AELE +   +   + +   L ++L   + +LH  Q  +    +AK  L   +R  E E 
Sbjct: 1303 QAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEA 1362

Query: 1636 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ---MS 1692
                  + E  +  E    +      Q+SE + +       +E  EE  +   R+   ++
Sbjct: 1363 AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALT 1422

Query: 1693 KHKTELKNILDMLQLENHELQG------LKL-QHDQRVSELEKTQ----VAVLEEKLELE 1741
            +   E    +D L+     LQ       + L Q  Q VS LEK Q      + EEK  + 
Sbjct: 1423 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV- 1481

Query: 1742 NLQQISQQQKGEIEWQKQ---------LLERDKREIERMTAESRALQSCVECLSKEKED- 1791
             L+ + ++++ E E +++          LE ++   E +  ++RAL++ +E L   K+D 
Sbjct: 1482 -LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1540

Query: 1792 ------LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR--KLQQELDQLNR 1843
                  L+  C + E+     +  +   E+     +    +LE+ V+  K Q E D   R
Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600

Query: 1844 DKLS------LHNDISAMQQQLQEKRE-------AVNSLQEELANVQDHLNLAKQDLLHT 1890
            D+        L   +   + +  E+R+       A   L+ EL  ++  +  A Q     
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660

Query: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
             K    + ++   L +++ E     E+   +    +++L+ L+ E+   + +L   +   
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720

Query: 1951 QRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSK-----------V 1996
            ++ Q++R+    E +    SK  + E++ QLE  L   + +L++  S            +
Sbjct: 1721 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1780

Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK------EADS 2050
            L  E     L  E  +    E    Q +RQ+ E   +L E+     A  K      E+  
Sbjct: 1781 LQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKL 1840

Query: 2051 MRADFSL---LRNQFLTER--KKAEKQ----VASLKEALKIQ---RSQLEKNLLEQKQEN 2098
             +A+  L    R + L+ +  ++AEK+    V  ++E  ++    R QLEK  L  KQ  
Sbjct: 1841 AQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ-- 1898

Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
              +++++   E  A       RRL +EL  +      + +++   ++  RR
Sbjct: 1899 --LKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947



 Score =  113 bits (282), Expect = 2e-24
 Identities = 176/868 (20%), Positives = 361/868 (41%), Gaps = 136/868 (15%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL------QEKKSL 1373
            +L    + L +  + L+S++         +R   +E+E L   ++D L      QE +S 
Sbjct: 1129 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1188

Query: 1374 -ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKR 1431
             E EV EL +T+++            E+ + E  +++  + H   + E+ E +E+   +R
Sbjct: 1189 REQEVTELKKTLEE------------ETRIHEAAVQELRQRHGQALGELAEQLEQA--RR 1234

Query: 1432 RSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
                 E  RL  EAE     +ELS  +   +   ++    +  L + +  A + ER   E
Sbjct: 1235 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1294

Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIK--------------QEEILKEINKIVAAKDSD 1532
             A  L +A  +L ++     + E   I+               +E+L+E  +   A  S 
Sbjct: 1295 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1354

Query: 1533 FQCLSKK--------------KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
             + +  +              +E+   ELQ  Q  +    R ++     L+  E   +  
Sbjct: 1355 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1414

Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
              E E L  ++  + + +  L+R  G ++     LQ  +  A  DL++  +L  T   ++
Sbjct: 1415 AREAEALTQRLAEKTETVDRLER--GRRR-----LQQELDDATMDLEQQRQLVSTLEKKQ 1467

Query: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
                  + E K+ +     ++     +  ER+ +   + + +E+E+E  + + RQ    +
Sbjct: 1468 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1527

Query: 1696 TELKNIL---DMLQLENHELQGLKLQHDQ-------RVSELEKTQVAVLEEKLELE-NLQ 1744
             EL+ +L   D +    HEL+      +Q       +V+ELE    A  + KL LE  +Q
Sbjct: 1528 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1587

Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK-- 1802
             +  Q + +++ + +  E  +R++ +   ++         + +++E  Q    +  +K  
Sbjct: 1588 ALKTQHERDLQGRDEAGEERRRQLAKQLRDAE--------VERDEERKQRTLAVAARKKL 1639

Query: 1803 ---LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
               L + K  +A+A +  +     L K++  +++L +E+++    +  + +     +++L
Sbjct: 1640 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1699

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDISEWA 1912
            +     V  LQEELA        A+QD       + +    +  +L E+ +L+  + +  
Sbjct: 1700 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1759

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
               E+ Q   E    + + L  ++E    +L  +     + +  R+  E +++  +  L 
Sbjct: 1760 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1819

Query: 1973 EQ------QHQ-----LEKELTDQKSKLDQ-----VLSKVLA--AEERVRTL----QEEE 2010
            E+      +H+     LE +L   + +L+Q     +LS  L   AE+R++ +    +EE 
Sbjct: 1820 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1879

Query: 2011 RWCESLEKTLS-------QTKRQLSEREQQLVEKSGELLALQKE-------ADSMRADFS 2056
            R  + L   L        Q KRQL E E++          LQ+E       A+SM  + +
Sbjct: 1880 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1939

Query: 2057 LLRNQF----LTERKKAEKQVASLKEAL 2080
             LRN+     LT   +  +QV  L+E +
Sbjct: 1940 TLRNRLRRGPLTFTTRTVRQVFRLEEGV 1967



 Score =  107 bits (267), Expect = 1e-22
 Identities = 198/959 (20%), Positives = 406/959 (42%), Gaps = 110/959 (11%)

Query: 255  VTTQDRQEAFERFSLEEVERLERDLEKKMIETE----ELKSKQTRFLEEIKNQDKLNKSL 310
            VT QD         L++V+ L++   +++ E +    +L+ ++ R  E+++ + +L    
Sbjct: 864  VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 923

Query: 311  KE---EAMLQKQSCE----ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
            +E       +KQ  E    EL++ +  + E  +Q   E  R  Q   ELE  L   +   
Sbjct: 924  EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 983

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            +   L    +E A++ K  ++   +     K  +      + D       +  E +E+++
Sbjct: 984  QKLQLEKVTTE-AKMKKFEEDLLLLEDQNSK--LSKERKLLEDRLAEFSSQAAEEEEKVK 1040

Query: 424  NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
            + +     +      +ED+ +K    +  L +L   ++    ++     E +Q  E ++ 
Sbjct: 1041 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100

Query: 484  ---KKISEAGKDLLYKQLSG--RLQLVNKLRQ-EALDLELQMEKQKQEIAGK--QKEIKD 535
               +K  E    L   +  G  R QL+  LR+ +A   E Q + + + +A    +K+ +D
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1160

Query: 536  LQIAIDSL-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL----ESRLDEILSRIA 586
            L   +++L     D+ D  ++  +  +S +EQ++  + K  ++     E+ + E+  R  
Sbjct: 1161 LGEELEALRGELEDTLDSTNAQQEL-RSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219

Query: 587  KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
            +   E+ +  EQ   G+  A E  +  LE  +S L+  L +++    + +   R+L  + 
Sbjct: 1220 QALGELAEQLEQARRGK-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1278

Query: 647  ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
            + +  R  + E+ R      A  AE +++  AELE+     +E  +   +   +LS+ EA
Sbjct: 1279 QEVQGRAGDGERAR------AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1332

Query: 707  ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA-----LGKAQFS 761
            +L     L   E  + K  L    R  + E + L+ +LE+E  A + A       +AQ S
Sbjct: 1333 QLHDAQELLQEET-RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1391

Query: 762  EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
            E + ++  E  A    L+      ++  ++ +     +   L    E   R++  RR+L+
Sbjct: 1392 EWRRRQEEEAGA----LEAGEEARRRAAREAEA----LTQRLAEKTETVDRLERGRRRLQ 1443

Query: 822  --LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---------ERDEAQVRERKLQ- 869
              L    M++     ++  +L   Q++F ++LA  K          ER EA+ RER+ + 
Sbjct: 1444 QELDDATMDLEQQRQLVS-TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1502

Query: 870  -------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE---------------- 906
                   EE    +E+L       R   E  L ++ +  K  HE                
Sbjct: 1503 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1562

Query: 907  ARIQQMENEIHYLQENLKSME------EIQGLTDLQ-LQEADEEKERILA-QLRELE--- 955
            A++ ++E+E+   ++    +E      + Q   DLQ   EA EE+ R LA QLR+ E   
Sbjct: 1563 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1622

Query: 956  ---KKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
               +K++     +++++ G  +ELK    +     + A  +L   + Q+K L   V +  
Sbjct: 1623 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1682

Query: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-EKTGVGTGAN 1071
              R E   +     ++      ++ R + E+    +  R++ +Q R EM ++   G  + 
Sbjct: 1683 TSREEIFSQNRESEKRLKGLEAEVLRLQEEL-AASDRARRQAQQDRDEMADEVANGNLSK 1741

Query: 1072 SQVLEIEK-LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
            + +LE ++ L   + +   E+   Q+  +L        +  +L ++  L  E+S +  +
Sbjct: 1742 AAILEEKRQLEGRLGQLEEELEEEQSNSELLND----RYRKLLLQVESLTTELSAERSF 1796



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 180/860 (20%), Positives = 350/860 (40%), Gaps = 133/860 (15%)

Query: 247  LESLEGQPVTTQDRQEAFERFSL---EEVERLERDLEKKM----IETEELKSKQTRFLEE 299
            LE+L G+   T D   A +       +EV  L++ LE++        +EL+ +  + L E
Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1224

Query: 300  IKNQ---DKLNKSLKEEAMLQKQS-CEELKSDLNTKNELLKQKTIELTRACQKQYELEQE 355
            +  Q    +  K   E+  L  ++   EL+++L++  +  +Q+  +  R  + Q +  Q 
Sbjct: 1225 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL-QTARQEGEQRRRRLELQLQEVQG 1283

Query: 356  LAFYKIDAKFEPLNYYPSEYAEIDKAPD-----ESPYIGKSRYKRNMFATESYIIDSAQA 410
             A     A+ E         AE++         ES  I   R  + + +TE+ + D+ + 
Sbjct: 1284 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI---RLSKELSSTEAQLHDAQEL 1340

Query: 411  VQIK---KMEPDEQLRNDHMNLRGHTPLDTQLEDKE-------KKISAAQTRLSELHDE- 459
            +Q +   K+    ++R       G   L  QLE++        +++  AQ +LSE     
Sbjct: 1341 LQEETRAKLALGSRVRAMEAEAAG---LREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1397

Query: 460  ------IEKAEQQILRATEEFKQLEEAIQLKKIS----EAGKDLLYKQLSG-------RL 502
                  +E  E+   RA  E + L + +  K  +    E G+  L ++L         + 
Sbjct: 1398 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1457

Query: 503  QLVNKLR------------QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
            QLV+ L             ++A  L    E+++ E  G+++E + L +   +L+ +    
Sbjct: 1458 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT-RALEEEQEAR 1516

Query: 551  SHMKAQKSGKEQQLDIMNKQYQQLESRLDEI--LSRIAKETE-----EIKDLEEQLTEGQ 603
              ++ Q      +L+ +      +   + E+    R+A++       ++ +LE++LT  +
Sbjct: 1517 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1576

Query: 604  IA------ANEALK----KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
             A        +ALK    +DL+G     +E    +  Q   A+ E  + R ++   +   
Sbjct: 1577 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1636

Query: 654  TEVEQERDQLEIVAMDA----ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
             ++E E ++L+     A    E   K+L ++++ ++E        + ++ ++ +   E E
Sbjct: 1637 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1696

Query: 710  ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ--- 766
             RL   +AE  +L+EEL    R     + A Q   E   +     L KA   EEK Q   
Sbjct: 1697 KRLKGLEAEVLRLQEELAASDR---ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1753

Query: 767  ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
               +L  +L+  Q ++ LL  + +     +  +   L      +A+ +  R++       
Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ------- 1806

Query: 827  MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
                            L++Q  E+  R   E   A+ R +     +A  + KLA  +E+ 
Sbjct: 1807 ----------------LERQIQELRGRLGEEDAGARARHKM---TIAALESKLAQAEEQL 1847

Query: 887  RQAC-ERALEARM--NFDKRQHEARIQQMENE--IHYLQENLKSMEEIQGLTDLQLQEAD 941
             Q   ER L  ++    +KR  E  +Q  E       L++ L+           QL+EA+
Sbjct: 1848 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1907

Query: 942  EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
            EE  R  A  R L+  ++LED    E    +++E+  L+      ++L    LT     +
Sbjct: 1908 EEASRAQAGRRRLQ--RELEDV--TESAESMNREVTTLR------NRLRRGPLTFTTRTV 1957

Query: 1002 KSLHGTVMKI-NQERAEELQ 1020
            + +      + + E AEE Q
Sbjct: 1958 RQVFRLEEGVASDEEAEEAQ 1977



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 121/654 (18%), Positives = 273/654 (41%), Gaps = 69/654 (10%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD--LLQEKKSLECEVE 1378
            L +  ++L D  + L+ + R +  + +  R  E E   L   +++    +E+   E +  
Sbjct: 1327 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1386

Query: 1379 ELHRTVQKRQQQKD---FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
            +   +  +R+Q+++      G         E E   +   +  + ++ +E+   + + EL
Sbjct: 1387 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1446

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET---AVNLV 1492
             +A   L +    +S  ++K +   +   + K ++L+   + E  E   +E    A++L 
Sbjct: 1447 DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1506

Query: 1493 KA-----------DQQLRSLQADAKDLEQHKIKQEEILKEINKIV-----AAKDSDFQCL 1536
            +A           ++Q R+L+A+ + L   K    + + E+ +       AA D   Q  
Sbjct: 1507 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1566

Query: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE- 1595
              + E    E  KL+ ++ +      H   +    E   + +R   ++L+     + +E 
Sbjct: 1567 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1626

Query: 1596 ----MAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
                +AV  R+ L  + EEL     S  Q K +  + LR  + ++ E    + E ++  E
Sbjct: 1627 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1686

Query: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN-------ILD 1703
            E+  Q  E   ++   + ++  +++E+   +   +   +   +   E+ N       IL+
Sbjct: 1687 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1746

Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK-----LELENLQ-QISQQQK--GEIE 1755
                E  +L+G   Q ++ + E E++   +L ++     L++E+L  ++S ++    + E
Sbjct: 1747 ----EKRQLEGRLGQLEEELEE-EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1801

Query: 1756 WQKQLLERDKREIERMTAESRA---------LQSCVECLSKEKEDLQEKCD--IWEKKLA 1804
              +Q LER  +E+     E  A         + +    L++ +E L+++    I   KL 
Sbjct: 1802 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1861

Query: 1805 QT-----KRVLAAAEENSKME---QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
            +      K V+   EE  ++    +  LEK  L V++L+++L++   +          +Q
Sbjct: 1862 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1921

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
            ++L++  E+  S+  E+  +++ L          T  Q   L E     ++  E
Sbjct: 1922 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1975


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score =  157 bits (396), Expect = 1e-37
 Identities = 223/1044 (21%), Positives = 430/1044 (41%), Gaps = 144/1044 (13%)

Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE--------- 1374
            +V+R ++++Q   ++ +E + ++  ++QS +E+ EL   +  L +E+  L          
Sbjct: 904  QVTRQDEVLQ---ARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 960

Query: 1375 -CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
              E EE    +  R+Q+ + +           E+E  +   E+   +++  +K L +   
Sbjct: 961  CAEAEETRGRLAARKQELELVVS---------ELEARVGEEEECSRQMQTEKKRLQQHIQ 1011

Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
            EL         A  +L   K  T+  ++KF   +  LL  E    +L +  +     L +
Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKF---EEDLLLLEDQNSKLSKERKLLEDRLAE 1068

Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
               Q    +   K L + ++K E           A  +D +   +K+EK  +EL+KL++ 
Sbjct: 1069 FSSQAAEEEEKVKSLNKLRLKYE-----------ATIADMEDRLRKEEKGRQELEKLKRR 1117

Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL- 1612
            ++                         E  +L+ Q+  QQQ    L  QLG K+EEL   
Sbjct: 1118 LD------------------------GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA 1153

Query: 1613 -------------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
                         L  S+ +A+A L EA    E+E   +    ++ + L EEL   +GEL
Sbjct: 1154 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1213

Query: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQ 1718
               +     Q     QE+  + E          +  TELK  L +  ++    +Q L+ +
Sbjct: 1214 EDTLDSTNAQ-----QELRSKRE----------QEVTELKKTLEEETRIHEAAVQELRQR 1258

Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
            H Q + EL                 +Q+ Q ++G+  W+K  L  +  E+  + AE  +L
Sbjct: 1259 HGQALGEL----------------AEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1301

Query: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
            Q+  +   + +  L+ +    + +    +R  A A E  +  Q+ LE +   + + + + 
Sbjct: 1302 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1361

Query: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
             +L+++  S    +   Q+ LQE+  A  +L   +  ++      ++ L      ++   
Sbjct: 1362 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAG 1421

Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
             E    Q  +SEW  R E+     E  ++  +    E E    +L ++     RL++ R 
Sbjct: 1422 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1481

Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCE 2014
              + +L+ + + L EQQ QL   L  ++ K DQ+L++  AA   +R ++E ER      E
Sbjct: 1482 RLQQELDDATMDL-EQQRQLVSTLEKKQRKFDQLLAEEKAAV--LRAVEERERAEAEGRE 1538

Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
               + LS T+    E EQ+  E+      L+++  ++RA+   L    L+ +    K V 
Sbjct: 1539 REARALSLTR--ALEEEQEAREE------LERQNRALRAELEAL----LSSKDDVGKSVH 1586

Query: 2075 SLKEALKIQR---SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQ 2128
             L+ A ++     + L   + E + E +  +     +E+  Q     HER  +   E  +
Sbjct: 1587 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1646

Query: 2129 MQYEYTELKKQMAN---QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
             +    +L KQ+ +   ++D ER+Q  ++ A R       +E++  + +  Q   E    
Sbjct: 1647 ERRR--QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1704

Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKL 2241
            L  +  + + L  E+E  + +     ++    EK    L    + + +E    +  R + 
Sbjct: 1705 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1764

Query: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
            +   D +  ++ +    +A +L + KRQ EG L  L  +++   E   S   +      L
Sbjct: 1765 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEE--EQSNSELLNDRYRKLL 1821

Query: 2302 SQLESSLTEDSQLGQNQEKNASAR 2325
             Q+ES  TE S       K  S R
Sbjct: 1822 LQVESLTTELSAERSFSAKAESGR 1845



 Score =  145 bits (367), Expect = 3e-34
 Identities = 220/1036 (21%), Positives = 441/1036 (42%), Gaps = 139/1036 (13%)

Query: 1368 QEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIE 1422
            ++ + L+   +EL + VQ+ QQQ     G ++  + +LE E++     L+   ++  E E
Sbjct: 907  RQDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 965

Query: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
                 L  R+ EL   + +++E E+ +   +E ++    +    ++ + + E+  E  E 
Sbjct: 966  ETRGRLAARKQEL---ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022

Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
              Q+  +  V  + +++  + D   LE    K    L +  K++  + ++F   + ++E+
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK----LSKERKLLEDRLAEFSSQAAEEEE 1078

Query: 1543 LTEELQKLQ-------KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
              + L KL+        D+E   R E+   Q L++ +  L  + +EL++   Q+  QQQ 
Sbjct: 1079 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQR 1135

Query: 1596 MAVLDRQLGHKKEELHL--------------LQGSMVQAKADLQEALRLGETEVTEKCNH 1641
               L  QLG K+EEL                L  S+ +A+A L EA    E+E   +   
Sbjct: 1136 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1195

Query: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
             ++ + L EEL   +GEL   +     Q     QE+  + E          +  TELK  
Sbjct: 1196 EKQRRDLGEELEALRGELEDTLDSTNAQ-----QELRSKRE----------QEVTELKKT 1240

Query: 1702 LDM-LQLENHELQGLKLQHDQRVSEL--------------EKTQVA----VLEEKLELEN 1742
            L+   ++    +Q L+ +H Q + EL              EKT++A    V E + EL +
Sbjct: 1241 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1300

Query: 1743 LQ---QISQQQKGEIEWQKQ------------------LLERDKREIERMTAESRALQSC 1781
            LQ   Q  +Q++  +E Q Q                   L+R + E+E ++      +S 
Sbjct: 1301 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1360

Query: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
               LSKE    + +    ++ L +  R   A     +  ++    L   + +     ++ 
Sbjct: 1361 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1420

Query: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
             R+  +    +S  +++ +E+  A+ + +E             Q L   T+  D L   +
Sbjct: 1421 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1480

Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
             RLQ+++ +     E  ++   T +++ +     + E K  +++     +R + E    E
Sbjct: 1481 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1540

Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV-RTLQEEERWCESLEKTL 2020
            ++  +    L+E+Q +  +EL  Q   L   L  +L++++ V +++ E ER C   E+  
Sbjct: 1541 ARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA 1599

Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRA----DFSLLRNQFLTERKKAEKQVASL 2076
            +  + Q++E E +L       L L+    +++     D           R++  KQ+   
Sbjct: 1600 NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA 1659

Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
            +     +R Q    +  +K+    +++  A +    Q   E  ++L K   QM+  + E+
Sbjct: 1660 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1719

Query: 2137 KKQMANQKDLERRQMEISDAMRTLKSEV---KDEIRTS---LKNLNQFLPELPADL---- 2186
            ++   +++++  +  E    ++ L++EV   ++E+  S    +   Q   E+  ++    
Sbjct: 1720 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1779

Query: 2187 ---EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRH 2243
                AILE    LEG L  L+E L         EE+ + S+  ++++ +R      KL  
Sbjct: 1780 LSKAAILEEKRQLEGRLGQLEEEL---------EEEQSNSE--LLNDRYR------KLLL 1822

Query: 2244 REDRLKAQL--RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
            + + L  +L      S +AE    G++Q E  +  LR +   LGE      A +    ++
Sbjct: 1823 QVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGR---LGE--EDAGARARHKMTI 1874

Query: 2302 SQLESSLTE-DSQLGQ 2316
            + LES L + + QL Q
Sbjct: 1875 AALESKLAQAEEQLEQ 1890



 Score =  116 bits (290), Expect = 3e-25
 Identities = 203/951 (21%), Positives = 386/951 (40%), Gaps = 131/951 (13%)

Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
            ++  L  E   LED +    S+  EE     S  +   + E    +++D L++++    E
Sbjct: 1051 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1110

Query: 1377 VEELHRTVQ----KRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
            +E+L R +     + Q+Q        E L  +L     E++ +L   ED           
Sbjct: 1111 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA----RAQ 1166

Query: 1428 LLKRRSELREADRLLAEAESELSCTK------EKTKNAVEKFTDAKRSLLQTESDA---- 1477
            LLK    LREA   LAEA+ +L   +      EK +  + +  +A R  L+   D+    
Sbjct: 1167 LLK---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1223

Query: 1478 EELERRAQETAVNLVKA-DQQLRSLQADAKDLEQHKIKQ----EEILKEINKIVAAKDSD 1532
            +EL  + ++    L K  +++ R  +A  ++L Q   +      E L++  +   A +  
Sbjct: 1224 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1283

Query: 1533 FQCLSKKKEKLTEELQKLQ---KDIEMAERNEDHHLQVLK-----------ESEVLLQAK 1578
               L  +  +L  EL  LQ   ++ E   R  +  LQ ++           E+   LQ  
Sbjct: 1284 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1343

Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEV 1635
            +AELE +   +   + +   L ++L   + +LH  Q  +    +AK  L   +R  E E 
Sbjct: 1344 QAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEA 1403

Query: 1636 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ---MS 1692
                  + E  +  E    +      Q+SE + +       +E  EE  +   R+   ++
Sbjct: 1404 AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALT 1463

Query: 1693 KHKTELKNILDMLQLENHELQG------LKL-QHDQRVSELEKTQ----VAVLEEKLELE 1741
            +   E    +D L+     LQ       + L Q  Q VS LEK Q      + EEK  + 
Sbjct: 1464 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV- 1522

Query: 1742 NLQQISQQQKGEIEWQKQ---------LLERDKREIERMTAESRALQSCVECLSKEKED- 1791
             L+ + ++++ E E +++          LE ++   E +  ++RAL++ +E L   K+D 
Sbjct: 1523 -LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1581

Query: 1792 ------LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR--KLQQELDQLNR 1843
                  L+  C + E+     +  +   E+     +    +LE+ V+  K Q E D   R
Sbjct: 1582 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1641

Query: 1844 DKLS------LHNDISAMQQQLQEKRE-------AVNSLQEELANVQDHLNLAKQDLLHT 1890
            D+        L   +   + +  E+R+       A   L+ EL  ++  +  A Q     
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1701

Query: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
             K    + ++   L +++ E     E+   +    +++L+ L+ E+   + +L   +   
Sbjct: 1702 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1761

Query: 1951 QRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSK-----------V 1996
            ++ Q++R+    E +    SK  + E++ QLE  L   + +L++  S            +
Sbjct: 1762 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1821

Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK------EADS 2050
            L  E     L  E  +    E    Q +RQ+ E   +L E+     A  K      E+  
Sbjct: 1822 LQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKL 1881

Query: 2051 MRADFSL---LRNQFLTER--KKAEKQ----VASLKEALKIQ---RSQLEKNLLEQKQEN 2098
             +A+  L    R + L+ +  ++AEK+    V  ++E  ++    R QLEK  L  KQ  
Sbjct: 1882 AQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ-- 1939

Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
              +++++   E  A       RRL +EL  +      + +++   ++  RR
Sbjct: 1940 --LKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988



 Score =  113 bits (282), Expect = 2e-24
 Identities = 176/868 (20%), Positives = 361/868 (41%), Gaps = 136/868 (15%)

Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL------QEKKSL 1373
            +L    + L +  + L+S++         +R   +E+E L   ++D L      QE +S 
Sbjct: 1170 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1229

Query: 1374 -ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKR 1431
             E EV EL +T+++            E+ + E  +++  + H   + E+ E +E+   +R
Sbjct: 1230 REQEVTELKKTLEE------------ETRIHEAAVQELRQRHGQALGELAEQLEQA--RR 1275

Query: 1432 RSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
                 E  RL  EAE     +ELS  +   +   ++    +  L + +  A + ER   E
Sbjct: 1276 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1335

Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIK--------------QEEILKEINKIVAAKDSD 1532
             A  L +A  +L ++     + E   I+               +E+L+E  +   A  S 
Sbjct: 1336 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1395

Query: 1533 FQCLSKK--------------KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
             + +  +              +E+   ELQ  Q  +    R ++     L+  E   +  
Sbjct: 1396 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1455

Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
              E E L  ++  + + +  L+R  G ++     LQ  +  A  DL++  +L  T   ++
Sbjct: 1456 AREAEALTQRLAEKTETVDRLER--GRRR-----LQQELDDATMDLEQQRQLVSTLEKKQ 1508

Query: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
                  + E K+ +     ++     +  ER+ +   + + +E+E+E  + + RQ    +
Sbjct: 1509 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1568

Query: 1696 TELKNIL---DMLQLENHELQGLKLQHDQ-------RVSELEKTQVAVLEEKLELE-NLQ 1744
             EL+ +L   D +    HEL+      +Q       +V+ELE    A  + KL LE  +Q
Sbjct: 1569 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1628

Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK-- 1802
             +  Q + +++ + +  E  +R++ +   ++         + +++E  Q    +  +K  
Sbjct: 1629 ALKTQHERDLQGRDEAGEERRRQLAKQLRDAE--------VERDEERKQRTLAVAARKKL 1680

Query: 1803 ---LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
               L + K  +A+A +  +     L K++  +++L +E+++    +  + +     +++L
Sbjct: 1681 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1740

Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDISEWA 1912
            +     V  LQEELA        A+QD       + +    +  +L E+ +L+  + +  
Sbjct: 1741 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1800

Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
               E+ Q   E    + + L  ++E    +L  +     + +  R+  E +++  +  L 
Sbjct: 1801 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1860

Query: 1973 EQ------QHQ-----LEKELTDQKSKLDQ-----VLSKVLA--AEERVRTL----QEEE 2010
            E+      +H+     LE +L   + +L+Q     +LS  L   AE+R++ +    +EE 
Sbjct: 1861 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1920

Query: 2011 RWCESLEKTLS-------QTKRQLSEREQQLVEKSGELLALQKE-------ADSMRADFS 2056
            R  + L   L        Q KRQL E E++          LQ+E       A+SM  + +
Sbjct: 1921 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1980

Query: 2057 LLRNQF----LTERKKAEKQVASLKEAL 2080
             LRN+     LT   +  +QV  L+E +
Sbjct: 1981 TLRNRLRRGPLTFTTRTVRQVFRLEEGV 2008



 Score =  107 bits (267), Expect = 1e-22
 Identities = 198/959 (20%), Positives = 406/959 (42%), Gaps = 110/959 (11%)

Query: 255  VTTQDRQEAFERFSLEEVERLERDLEKKMIETE----ELKSKQTRFLEEIKNQDKLNKSL 310
            VT QD         L++V+ L++   +++ E +    +L+ ++ R  E+++ + +L    
Sbjct: 905  VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 964

Query: 311  KE---EAMLQKQSCE----ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
            +E       +KQ  E    EL++ +  + E  +Q   E  R  Q   ELE  L   +   
Sbjct: 965  EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 1024

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            +   L    +E A++ K  ++   +     K  +      + D       +  E +E+++
Sbjct: 1025 QKLQLEKVTTE-AKMKKFEEDLLLLEDQNSK--LSKERKLLEDRLAEFSSQAAEEEEKVK 1081

Query: 424  NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
            + +     +      +ED+ +K    +  L +L   ++    ++     E +Q  E ++ 
Sbjct: 1082 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141

Query: 484  ---KKISEAGKDLLYKQLSG--RLQLVNKLRQ-EALDLELQMEKQKQEIAGK--QKEIKD 535
               +K  E    L   +  G  R QL+  LR+ +A   E Q + + + +A    +K+ +D
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1201

Query: 536  LQIAIDSL-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL----ESRLDEILSRIA 586
            L   +++L     D+ D  ++  +  +S +EQ++  + K  ++     E+ + E+  R  
Sbjct: 1202 LGEELEALRGELEDTLDSTNAQQEL-RSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260

Query: 587  KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
            +   E+ +  EQ   G+  A E  +  LE  +S L+  L +++    + +   R+L  + 
Sbjct: 1261 QALGELAEQLEQARRGK-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1319

Query: 647  ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
            + +  R  + E+ R      A  AE +++  AELE+     +E  +   +   +LS+ EA
Sbjct: 1320 QEVQGRAGDGERAR------AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1373

Query: 707  ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA-----LGKAQFS 761
            +L     L   E  + K  L    R  + E + L+ +LE+E  A + A       +AQ S
Sbjct: 1374 QLHDAQELLQEET-RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1432

Query: 762  EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
            E + ++  E  A    L+      ++  ++ +     +   L    E   R++  RR+L+
Sbjct: 1433 EWRRRQEEEAGA----LEAGEEARRRAAREAEA----LTQRLAEKTETVDRLERGRRRLQ 1484

Query: 822  --LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---------ERDEAQVRERKLQ- 869
              L    M++     ++  +L   Q++F ++LA  K          ER EA+ RER+ + 
Sbjct: 1485 QELDDATMDLEQQRQLVS-TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1543

Query: 870  -------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE---------------- 906
                   EE    +E+L       R   E  L ++ +  K  HE                
Sbjct: 1544 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1603

Query: 907  ARIQQMENEIHYLQENLKSME------EIQGLTDLQ-LQEADEEKERILA-QLRELE--- 955
            A++ ++E+E+   ++    +E      + Q   DLQ   EA EE+ R LA QLR+ E   
Sbjct: 1604 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1663

Query: 956  ---KKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
               +K++     +++++ G  +ELK    +     + A  +L   + Q+K L   V +  
Sbjct: 1664 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1723

Query: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-EKTGVGTGAN 1071
              R E   +     ++      ++ R + E+    +  R++ +Q R EM ++   G  + 
Sbjct: 1724 TSREEIFSQNRESEKRLKGLEAEVLRLQEEL-AASDRARRQAQQDRDEMADEVANGNLSK 1782

Query: 1072 SQVLEIEK-LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
            + +LE ++ L   + +   E+   Q+  +L        +  +L ++  L  E+S +  +
Sbjct: 1783 AAILEEKRQLEGRLGQLEEELEEEQSNSELLND----RYRKLLLQVESLTTELSAERSF 1837



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 180/860 (20%), Positives = 350/860 (40%), Gaps = 133/860 (15%)

Query: 247  LESLEGQPVTTQDRQEAFERFSL---EEVERLERDLEKKM----IETEELKSKQTRFLEE 299
            LE+L G+   T D   A +       +EV  L++ LE++        +EL+ +  + L E
Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1265

Query: 300  IKNQ---DKLNKSLKEEAMLQKQS-CEELKSDLNTKNELLKQKTIELTRACQKQYELEQE 355
            +  Q    +  K   E+  L  ++   EL+++L++  +  +Q+  +  R  + Q +  Q 
Sbjct: 1266 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL-QTARQEGEQRRRRLELQLQEVQG 1324

Query: 356  LAFYKIDAKFEPLNYYPSEYAEIDKAPD-----ESPYIGKSRYKRNMFATESYIIDSAQA 410
             A     A+ E         AE++         ES  I   R  + + +TE+ + D+ + 
Sbjct: 1325 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI---RLSKELSSTEAQLHDAQEL 1381

Query: 411  VQIK---KMEPDEQLRNDHMNLRGHTPLDTQLEDKE-------KKISAAQTRLSELHDE- 459
            +Q +   K+    ++R       G   L  QLE++        +++  AQ +LSE     
Sbjct: 1382 LQEETRAKLALGSRVRAMEAEAAG---LREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1438

Query: 460  ------IEKAEQQILRATEEFKQLEEAIQLKKIS----EAGKDLLYKQLSG-------RL 502
                  +E  E+   RA  E + L + +  K  +    E G+  L ++L         + 
Sbjct: 1439 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1498

Query: 503  QLVNKLR------------QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
            QLV+ L             ++A  L    E+++ E  G+++E + L +   +L+ +    
Sbjct: 1499 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT-RALEEEQEAR 1557

Query: 551  SHMKAQKSGKEQQLDIMNKQYQQLESRLDEI--LSRIAKETE-----EIKDLEEQLTEGQ 603
              ++ Q      +L+ +      +   + E+    R+A++       ++ +LE++LT  +
Sbjct: 1558 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1617

Query: 604  IA------ANEALK----KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
             A        +ALK    +DL+G     +E    +  Q   A+ E  + R ++   +   
Sbjct: 1618 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1677

Query: 654  TEVEQERDQLEIVAMDA----ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
             ++E E ++L+     A    E   K+L ++++ ++E        + ++ ++ +   E E
Sbjct: 1678 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1737

Query: 710  ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ--- 766
             RL   +AE  +L+EEL    R     + A Q   E   +     L KA   EEK Q   
Sbjct: 1738 KRLKGLEAEVLRLQEELAASDR---ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1794

Query: 767  ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
               +L  +L+  Q ++ LL  + +     +  +   L      +A+ +  R++       
Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ------- 1847

Query: 827  MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
                            L++Q  E+  R   E   A+ R +     +A  + KLA  +E+ 
Sbjct: 1848 ----------------LERQIQELRGRLGEEDAGARARHKM---TIAALESKLAQAEEQL 1888

Query: 887  RQAC-ERALEARM--NFDKRQHEARIQQMENE--IHYLQENLKSMEEIQGLTDLQLQEAD 941
             Q   ER L  ++    +KR  E  +Q  E       L++ L+           QL+EA+
Sbjct: 1889 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1948

Query: 942  EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
            EE  R  A  R L+  ++LED    E    +++E+  L+      ++L    LT     +
Sbjct: 1949 EEASRAQAGRRRLQ--RELEDV--TESAESMNREVTTLR------NRLRRGPLTFTTRTV 1998

Query: 1002 KSLHGTVMKI-NQERAEELQ 1020
            + +      + + E AEE Q
Sbjct: 1999 RQVFRLEEGVASDEEAEEAQ 2018



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 121/654 (18%), Positives = 273/654 (41%), Gaps = 69/654 (10%)

Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD--LLQEKKSLECEVE 1378
            L +  ++L D  + L+ + R +  + +  R  E E   L   +++    +E+   E +  
Sbjct: 1368 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1427

Query: 1379 ELHRTVQKRQQQKD---FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
            +   +  +R+Q+++      G         E E   +   +  + ++ +E+   + + EL
Sbjct: 1428 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1487

Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET---AVNLV 1492
             +A   L +    +S  ++K +   +   + K ++L+   + E  E   +E    A++L 
Sbjct: 1488 DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1547

Query: 1493 KA-----------DQQLRSLQADAKDLEQHKIKQEEILKEINKIV-----AAKDSDFQCL 1536
            +A           ++Q R+L+A+ + L   K    + + E+ +       AA D   Q  
Sbjct: 1548 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1607

Query: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE- 1595
              + E    E  KL+ ++ +      H   +    E   + +R   ++L+     + +E 
Sbjct: 1608 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1667

Query: 1596 ----MAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
                +AV  R+ L  + EEL     S  Q K +  + LR  + ++ E    + E ++  E
Sbjct: 1668 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1727

Query: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN-------ILD 1703
            E+  Q  E   ++   + ++  +++E+   +   +   +   +   E+ N       IL+
Sbjct: 1728 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1787

Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK-----LELENLQ-QISQQQK--GEIE 1755
                E  +L+G   Q ++ + E E++   +L ++     L++E+L  ++S ++    + E
Sbjct: 1788 ----EKRQLEGRLGQLEEELEE-EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1842

Query: 1756 WQKQLLERDKREIERMTAESRA---------LQSCVECLSKEKEDLQEKCD--IWEKKLA 1804
              +Q LER  +E+     E  A         + +    L++ +E L+++    I   KL 
Sbjct: 1843 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1902

Query: 1805 QT-----KRVLAAAEENSKME---QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
            +      K V+   EE  ++    +  LEK  L V++L+++L++   +          +Q
Sbjct: 1903 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1962

Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
            ++L++  E+  S+  E+  +++ L          T  Q   L E     ++  E
Sbjct: 1963 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 2016


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  157 bits (396), Expect = 1e-37
 Identities = 220/1037 (21%), Positives = 456/1037 (43%), Gaps = 187/1037 (18%)

Query: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQS----EKEMEELHHNIDDLLQEKKSLECEV 1377
            + +V  L + M+ L SK   +     +K ++    EK + EL     DL ++ +   C+ 
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853

Query: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECI-----------EK 1426
            +EL + V+             E L ++LE+       EDI D +  +           E 
Sbjct: 1854 QELLQRVETS-----------EGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVEN 1902

Query: 1427 TLLKRRSELR--EADRLLAEAESELS-----CTKEKTKNAVEKFTDAKRSLLQTESDAEE 1479
             L + RSE    E + L  EA+ E+      C ++  +N  +     +  L    S+  +
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962

Query: 1480 LERRAQETAVNLVKADQQLRSLQADAKDLEQHKIK-------QEEILKEINKIVAAKDSD 1532
            L       +      DQ    ++   ++LE H+ +        E  +KE  +++    SD
Sbjct: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD 2022

Query: 1533 FQCLSKKKEKLTEELQKLQKDI------------EMAERNEDHHLQVLKESEVLLQAKRA 1580
               L K K  L E+LQ L+KD             ++A+ N++  L ++KESE  LQA+ +
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL-LVKESE-SLQARLS 2080

Query: 1581 ELEKLKSQVTSQQQEMAVLDR-----QLGHKKEELHLLQGSM----VQAKADLQEALRLG 1631
            E +  K  V S+  E A++++     +L   +EE+H L+  +    V+ +AD ++ L + 
Sbjct: 2081 ESDYEKLNV-SKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139

Query: 1632 ETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE-ENLQVVLRQ 1690
            E ++ E+      +K  +E L     E  +Q+SE   +L ++  E  K E E L+  + +
Sbjct: 2140 E-KLKERERENDSLKDKVENL-----ERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193

Query: 1691 MSKH-----------KTELKNILDMLQLENHELQGL-------------KLQHDQRVSEL 1726
            M++            ++E +N+   +Q +  +L  L             K Q + ++ E 
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253

Query: 1727 EKTQVAVLEEKL------------ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE 1774
             KT V +L+ +L            + E ++   Q     IE + QL    +  IE++ A 
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQL----RNSIEKLRAR 2309

Query: 1775 SRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAA---EENSKMEQSN----LEKL 1827
              A +    C+ ++ ++ +   D+ + ++   +R L  A   +E++ +E  N    +E L
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369

Query: 1828 ELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL 1887
            +  +  + Q L  L  D +++ ++   +  +LQ+++E ++ L+   ++ ++ L   +Q+ 
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429

Query: 1888 LH----TTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQ---------- 1933
            +     ++   ++L ++   L + ++   N  E C+ +E+    Q++ L+          
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489

Query: 1934 ------------------NEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQ 1975
                               E+E+ K KL +++    RL+ + + +E  +  SK++  E +
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV--SKLSQVEGE 2547

Query: 1976 HQLEKE--------LTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
            HQL KE          + + K+  + SK  + ++ +  LQ   +  E+  +     K   
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607

Query: 2028 SEREQQLVEKSGELL----ALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK-- 2081
             E+  ++  K  EL      + ++   ++ + S  +N+   E +   +++ S K+ LK  
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667

Query: 2082 -IQRSQLEKNL----LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYE---Y 2133
             ++ S+L+K+L     +Q ++   +++E+A  +L   +  ++ + L+ + N+ QYE    
Sbjct: 2668 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNK-QYEVEIQ 2726

Query: 2134 TELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD-------L 2186
            T  +K  + ++ L  +++EI      LKS  K+E+  SLK   Q L EL          +
Sbjct: 2727 TYREKLTSKEECLSSQKLEID----LLKSS-KEELNNSLKATTQILEELKKTKMDNLKYV 2781

Query: 2187 EAILERNENLEGELESL 2203
              + + NE  +G+++ L
Sbjct: 2782 NQLKKENERAQGKMKLL 2798



 Score =  150 bits (378), Expect = 2e-35
 Identities = 177/852 (20%), Positives = 372/852 (43%), Gaps = 113/852 (13%)

Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK 1386
            RL    + +   +R    +R      EK+   +   + +  +E  SL+ +VE L R +Q 
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165

Query: 1387 RQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAE 1446
             ++ ++ +  + E+   E+E  K+    E++   ++  E  L+  RSE     + + E +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKT--QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223

Query: 1447 SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAK 1506
             +LS         ++K   + +SLL+ +  AE   +   +TAV +++             
Sbjct: 2224 GQLS--------ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ----------- 2264

Query: 1507 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1566
                        LKE+N+ VAA   D + +     K TE  Q L   IE     E+H L 
Sbjct: 2265 ------------LKELNEAVAALCGDQEIM-----KATE--QSLDPPIE-----EEHQL- 2299

Query: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQE 1626
                        R  +EKL++++ + +++   + +QL   +    LL+G +   + +L+ 
Sbjct: 2300 ------------RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI 2347

Query: 1627 ALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKEEEN 1683
            A    E    E  N   EV++L   +E ++     L + +   +++   +  E++KE+E 
Sbjct: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407

Query: 1684 LQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLE-LEN 1742
            +     ++    +  +NIL   + E  +++    +      E+ +TQ+  L E++  L N
Sbjct: 2408 IS----ELEIINSSFENILQEKEQEKVQMK----EKSSTAMEMLQTQLKELNERVAALHN 2459

Query: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMTAESR----ALQSCVECLSKEKEDLQEKCDI 1798
             Q+  + ++  +  Q + LE +K ++ +   E++     LQS V  L +E ED ++K + 
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519

Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
             ++++++ K  +    ++ +   S L ++E   +  +++  +L    + L   I  +Q +
Sbjct: 2520 KDEEISRLKNQI----QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
                ++ +  LQ    N+++ L L K D +   +  + + +++T LQ+++ E A +  + 
Sbjct: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635

Query: 1919 QKEEETKQQ----QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 1974
            Q+E   ++     +LQ+L  EI+ +K +L           KE   E S+L+ S   + + 
Sbjct: 2636 QEELSGEKNRLAGELQLLLEEIKSSKDQL-----------KELTLENSELKKSLDCMHKD 2684

Query: 1975 QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQL 2034
            Q + E ++ ++             AE ++R  + E++    L  T  Q + ++    ++L
Sbjct: 2685 QVEKEGKVREE------------IAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732

Query: 2035 VEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ 2094
              K   L + + E D +++    L N          K    + E LK  +    K + + 
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKEELNNSL--------KATTQILEELKKTKMDNLKYVNQL 2784

Query: 2095 KQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
            K+EN   Q +M  +    +   E    L KEL+Q+Q    + K        ++    EI 
Sbjct: 2785 KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIK 2844

Query: 2155 DAMRTLKSEVKD 2166
            +   TL+ + K+
Sbjct: 2845 ELKETLEEKTKE 2856



 Score =  133 bits (335), Expect = 2e-30
 Identities = 185/969 (19%), Positives = 416/969 (42%), Gaps = 135/969 (13%)

Query: 1342 ERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQK---------- 1391
            E W      ++ ++++EL   +D L +EK+  + +++ L   +QK++Q+           
Sbjct: 6    EEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL 65

Query: 1392 -----------DFIDGNVESLMTELEIEKSLKHHED-----IVDEIECIEKTLLKRRSEL 1435
                       + ++   + +  EL++++S  + ++        +IE +E+ L + +SEL
Sbjct: 66   KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSEL 125

Query: 1436 READRLLAEAESELSCTKEKTK------NAVEKFTDAKRSLLQTESDAEELERR---AQE 1486
              + +    A+  L+      K         + ++ +K   L+ + + E  ER+   A+ 
Sbjct: 126  ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185

Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE----- 1541
             A+   KA Q L     + +D+ +H+        +  K  +   S+ Q    +++     
Sbjct: 186  KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245

Query: 1542 -KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD 1600
                +E+   +  +++ +R+ +        S  LL   +A+ ++L++++   +  +   +
Sbjct: 246  FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305

Query: 1601 RQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH------------------- 1641
            +++  +  +   LQ  + +AK +L E     + +V  KC                     
Sbjct: 306  KEMKGQVNKFQELQLQLEKAKVELIE-----KEKVLNKCRDELVRTTAQYDQASTKYTAL 360

Query: 1642 IREVKSLLEELSFQKG-------ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKH 1694
             +++K L E+LS Q+         L  +I E++ +    ++E+ +++ + Q + ++  + 
Sbjct: 361  EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE---FQEELSRQQRSFQTLDQECIQM 417

Query: 1695 KTEL-------KNILDMLQLENHELQGLKLQHDQRVSELE----KTQVAVLEEKLELENL 1743
            K  L       KN+ ++LQ E  +L  +K Q +  + E +    + + A    +++   L
Sbjct: 418  KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENEL 477

Query: 1744 QQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV--------ECLSKEK------ 1789
            ++  ++ K E    K   E+  RE+  + AE + ++ C+        E  +K        
Sbjct: 478  RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537

Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAA--EENSKMEQSNLEKLELNVRKLQQELDQLNRDKLS 1847
             DLQEK +  E  L   K  LA A  E+     Q  L+K E ++ +L  +L +  ++  +
Sbjct: 538  RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597

Query: 1848 LHNDISAMQ------QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
            L   +SA++      ++L+E++   +  + E   +   +   K++L     H +  L  Q
Sbjct: 598  L---LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654

Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
               Q    E+  R    + + E    +++ L N ++   +++  Q++ +  LQ++ E  +
Sbjct: 655  ---QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD 711

Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLS 2021
             K +     +  +  QL  ++ D + KL  + ++++   ++ R  Q+     ESL   L 
Sbjct: 712  QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM---DKDRCYQDLHAEYESLRDLLK 768

Query: 2022 QTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQV---ASLKE 2078
                 L   E    +    LLA  ++     +  +++  Q     +++E ++    S K 
Sbjct: 769  SKDASLVTNE----DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN 824

Query: 2079 ALKIQR--SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
            +  +Q     LE +L  QKQ NS +QK+    E + Q   E    LMK     Q    E 
Sbjct: 825  SAILQNRVDSLEFSLESQKQMNSDLQKQ---CEELVQIKGEIEENLMKAEQMHQSFVAET 881

Query: 2137 KKQMAN-QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN 2195
             ++++  Q+D    Q  +++ +  L+++ K+     L+ LN  +    A+++ + + N  
Sbjct: 882  SQRISKLQEDTSAHQNVVAETLSALENKEKE-----LQLLNDKVETEQAEIQELKKSNHL 936

Query: 2196 LEGELESLK 2204
            LE  L+ L+
Sbjct: 937  LEDSLKELQ 945



 Score =  128 bits (321), Expect = 7e-29
 Identities = 178/882 (20%), Positives = 367/882 (41%), Gaps = 94/882 (10%)

Query: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTV------QKRQQQKDFIDGNVESL 1401
            S+  S  + E+L    +  ++E+K LE EV+ L          Q     +D       S 
Sbjct: 156  SQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSS 215

Query: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKR--RSELREADRLLAEAESELSCTKEKTKNA 1459
            +   + EK+  H           ++T ++R   +     ++ +  + S L   K    ++
Sbjct: 216  VFSWQQEKTPSHLSSNS------QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSS 269

Query: 1460 VEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS-------LQADAKDLEQHK 1512
                + +   L Q ++  +EL  +  E  + L   +++++        LQ   +  +   
Sbjct: 270  FFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL 329

Query: 1513 IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESE 1572
            I++E++L +    +    + +   S K   L ++L+KL +D+    +N +        + 
Sbjct: 330  IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAE-------SAR 382

Query: 1573 VLLQAKRAELEK-LKSQVTSQQQEMAVLDRQLGHKKEEL--HLLQG----SMVQAKAD-L 1624
              L+ K  E EK  + +++ QQ+    LD++    K  L   L Q     +++QA+ D L
Sbjct: 383  CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442

Query: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
                +  E  + E    +   +   +    ++ EL   + E K +  L+K   E++    
Sbjct: 443  TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA--- 499

Query: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAV--LEEKLELEN 1742
                R++   + ELKNI   L    +  + +K ++  + + L   Q  +   E  L LE 
Sbjct: 500  ----REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555

Query: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMT-------AESRALQSCVECLSKEKEDLQEK 1795
            L+      + + +  + LL++ +  IE++         ES+AL S +E   KE E+L+E+
Sbjct: 556  LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615

Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
              ++    ++ +++L   E   +  QS +  LE  ++  Q +  + N    +L  D   +
Sbjct: 616  KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675

Query: 1856 QQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF 1915
              +++     ++S   E+           Q L +    Q    S+Q + QK+I     + 
Sbjct: 676  SVEIRNLHNVLDSKSVEVET---------QKLAYMELQQKAEFSDQ-KHQKEIENMCLKT 725

Query: 1916 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL-KEQ 1974
                 + E  + +LQ+L NEI       + ++  +Q L  E ES    L++   +L   +
Sbjct: 726  SQLTGQVEDLEHKLQLLSNEI-------MDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778

Query: 1975 QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE---------------ERWCESLEKT 2019
             HQ      DQ+  +    + ++  +  + + + E               +   +SLE +
Sbjct: 779  DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838

Query: 2020 LSQTKRQLSEREQQ---LVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASL 2076
            L   K+  S+ ++Q   LV+  GE+     +A+ M   F    +Q ++   K ++  ++ 
Sbjct: 839  LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS---KLQEDTSAH 895

Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
            +  +    S LE    E +  N  ++ E A I+ + + NH      +KEL  +    +  
Sbjct: 896  QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH-LLEDSLKELQLLSETLSLE 954

Query: 2137 KKQMANQKDLERRQM-EISDAMRTLKSEVKDEIRTSLKNLNQ 2177
            KK+M++   L +R++ E++    TLK E+   +     NL Q
Sbjct: 955  KKEMSSIISLNKREIEELTQENGTLK-EINASLNQEKMNLIQ 995



 Score =  127 bits (319), Expect = 1e-28
 Identities = 234/1048 (22%), Positives = 447/1048 (42%), Gaps = 168/1048 (16%)

Query: 96   NLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYN-LIGKIEKLDK-LLKLRELN 153
            +L ++++  L L KD   K K I  LE+  +L V+    N L G+++ + K    L +L+
Sbjct: 1924 DLEVVQTEKLCLEKDNENKQKVIVCLEE--ELSVVTSERNQLRGELDTMSKKTTALDQLS 1981

Query: 154  LSYN-KISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDIS 212
                 K  ++E  ++ C L  + +A  E++     L  +  S  V  L  +K    + + 
Sbjct: 1982 EKMKEKTQELESHQSEC-LHCIQVAEAEVKEKTELL--QTLSSDVSELLKDKTHLQEKLQ 2038

Query: 213  KLKPLQDLISLIL--VENPVVTLPHYLQFTIFHLRSLES-LEGQPVTTQDRQEAFE---- 265
             L+     +SL    +EN +  L    +  +    SL++ L        +  +A E    
Sbjct: 2039 SLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALV 2098

Query: 266  ---RFSL------EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAML 316
                F+L      EEV +L R +EK  +  E  + KQ    E++K +++ N SLK++   
Sbjct: 2099 EKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV-- 2156

Query: 317  QKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYA 376
                 E L+ +L    E                    QEL                   A
Sbjct: 2157 -----ENLERELQMSEE-------------------NQELVILD---------------A 2177

Query: 377  EIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
            E  KA  E+               ++ I + A+++++ +++    LR++  NL       
Sbjct: 2178 ENSKAEVET--------------LKTQIEEMARSLKVFELDL-VTLRSEKENLT------ 2216

Query: 437  TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLL 494
             Q+++K+ ++S     LS     +E+ EQ  ++  EE K   E +Q  LK+++EA   L 
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276

Query: 495  YKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMK 554
              Q       + K  +++LD  ++ E Q +    K +           L++ + K   + 
Sbjct: 2277 GDQE------IMKATEQSLDPPIEEEHQLRNSIEKLRA---------RLEADEKKQLCVL 2321

Query: 555  AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDL 614
             Q    E   D++  + + LE  L+     IA+  +E   LE + ++G++   E LK  +
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELE-----IARTNQEHAALEAENSKGEV---ETLKAKI 2373

Query: 615  EGV---ISGLQEYLGTIKGQATQAQNECRKLRD---EKETLLQRLTEVEQERDQLEIVAM 668
            EG+   + GL+  + TI+ +     NE +K ++   E E +      + QE++Q ++   
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433

Query: 669  DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK 728
            +  +   E+  L++ L+E +E  A+L   Q    A E  L +++   + E  QL + L++
Sbjct: 2434 EKSSTAMEM--LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491

Query: 729  VTR---LTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLL 785
                  + Q   + L  E+E  +Q L+    +    + + Q+  +L +KL  ++ ++ L 
Sbjct: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW 2551

Query: 786  KQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK-LGTGEMNIHSPSDVLGKSLADLQ 844
            K+Q  + +N                    EL +K++ L +   ++    +VL  S  +L+
Sbjct: 2552 KEQNLELRN-----------------LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594

Query: 845  KQFSEILARSKW----ERDEAQVRERKLQEEMALQQEKLATGQEEFRQACER-ALEARMN 899
             +  E+    K     + ++   +E +LQ EM    +K A  QEE      R A E ++ 
Sbjct: 2595 NEL-ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653

Query: 900  FDK-RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKK 958
             ++ +  + +++++  E   L+++L  M + Q   + +++E   E +    +L E EKK 
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ---LRLHEAEKKH 2710

Query: 959  K---LEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK-SLHGTVMKINQE 1014
            +   L+  K  E      +E    K+   +S KL    L  +K++L  SL  T   + + 
Sbjct: 2711 QALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEEL 2770

Query: 1015 RAEEL----------QEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064
            +  ++          +E ER   K     +   + E E E+LQ  L Q   Q   E +KT
Sbjct: 2771 KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL--QAAQEKQKT 2828

Query: 1065 G--VGTGANSQVLEIEKLNETMERQRTE 1090
            G  + T  +    EI++L ET+E +  E
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKE 2856



 Score =  123 bits (308), Expect = 2e-27
 Identities = 204/1031 (19%), Positives = 429/1031 (41%), Gaps = 131/1031 (12%)

Query: 1314 NVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373
            ++ E  N +     LE +   +   +++    +   ++ E  +E+L+  +    +E K+L
Sbjct: 539  DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598

Query: 1374 ECEVEELHRTVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLK 1430
               +E   +  ++ +++K          E L+T++E EK  ++ +  ++ +E   KT   
Sbjct: 599  LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEK--ENLQSKINHLETCLKTQQI 656

Query: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVE----KFTDAKRSLLQTESDAEELERRAQE 1486
            +  E  E  R L      LS       N ++    +    K + ++ +  AE  +++ Q+
Sbjct: 657  KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716

Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEE 1546
               N+     QL       +DLE HK      L+ ++  +  KD  +Q L  + E L + 
Sbjct: 717  EIENMCLKTSQLTG---QVEDLE-HK------LQLLSNEIMDKDRCYQDLHAEYESLRDL 766

Query: 1547 LQKLQKDIEMAERNEDHHLQVLK-ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1605
            L+   KD  +   NEDH   +L  + +  +    A +   +  + S++ E  +   +   
Sbjct: 767  LKS--KDASLVT-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL---EADQ 820

Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ-IS 1664
              +   +LQ  +   +  L+   ++  +++ ++C  + ++K  +EE   +  +++   ++
Sbjct: 821  SPKNSAILQNRVDSLEFSLESQKQMN-SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA 879

Query: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
            E   +++ ++++    +  +   L  +   + EL+ + D ++ E  E+Q LK  +     
Sbjct: 880  ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLED 939

Query: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
             L++ Q+  L E L LE  +  S            ++  +KREIE +T E+  L+     
Sbjct: 940  SLKELQL--LSETLSLEKKEMSS------------IISLNKREIEELTQENGTLKEINAS 985

Query: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
            L++EK +L +K + +   + + ++ ++   +  K E+  L               Q   +
Sbjct: 986  LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL--------------QRCEE 1031

Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
              + + D+S   +  QEK   +  L  E  ++ ++     + L      ++    E    
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL------KEAFAKEHQEF 1085

Query: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
               ++    R ++   E ET Q   Q L++E+ +N              Q   +SE   L
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQ---QALRSEMTDN--------------QNNSKSEAGGL 1128

Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTK 2024
            +   +TLKE+Q++++KE+ D   + +Q L KV+  +   + L+         E   +  K
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQ-LMKVMKTKHECQNLES--------EPIRNSVK 1179

Query: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADF----SLLRNQFLTERKKAEKQVASLKEAL 2080
             + SER Q   +   +L   +   DS  A      ++LRN+ L + +++EK+   L+  L
Sbjct: 1180 ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKEL-KLQESEKEKECLQHEL 1238

Query: 2081 KIQRSQLEKNLLE--QKQENSCIQK-EMATIELVAQDNHERARRLMKELNQMQYEYTELK 2137
            +  R  LE + L+  Q QE S ++  E+   E      HE    L    N   +    L+
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE----LSTSQNDNAHLQCSLQ 1294

Query: 2138 KQMANQKDLERRQMEISDAMRTLKSEVKD---EIRTSLKNLNQFLPELPADLEAILERNE 2194
              M    +LE+    +      L +E+ D   E  T+ + + + + +L  +++ + + + 
Sbjct: 1295 TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSG 1354

Query: 2195 NLEGEL----------ESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHR 2244
             L GEL          E   E  P ++   P +E  ++  + + D+    E        +
Sbjct: 1355 LLHGELVEDIPGGEFGEQPNEQHPVSL--APLDESNSYEHLTLSDK----EVQMHFAELQ 1408

Query: 2245 EDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQL 2304
            E  L  Q  H      ++L     Q    +  L+  VD+L       + +   S +L   
Sbjct: 1409 EKFLSLQSEH------KILHDQHCQMSSKMSELQTYVDSL------KAENLVLSTNLRNF 1456

Query: 2305 ESSLTEDSQLG 2315
            +  L ++ QLG
Sbjct: 1457 QGDLVKEMQLG 1467



 Score =  111 bits (277), Expect = 9e-24
 Identities = 234/1090 (21%), Positives = 446/1090 (40%), Gaps = 184/1090 (16%)

Query: 170  NLQKLNLAGNEIEHIPVWLGKKLKSL-----RVLNLKGNKISSLQDISKLKPLQDLISLI 224
            +LQ+ NL   E    P    ++L+SL     + L     K+ S Q I K K +Q+L  L+
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMES-QGIMKNKEIQELEQLL 1588

Query: 225  LVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR-QEAFERFSLEEVERLERDLEKKM 283
              E                 + L+ L  Q ++  ++ Q+     +LE   +L    EKK 
Sbjct: 1589 SSER----------------QELDCLRKQYLSENEQWQQKLTSVTLEMESKLAA--EKKQ 1630

Query: 284  IETEELKSKQTRFLEEIKNQDKLNKSL----KEEAML-QKQSCEELKSDLNTKNELLKQK 338
             E   L+ +  R   +++  D  ++SL     E+A+  + +SC+  K   +   E   + 
Sbjct: 1631 TEQLSLELEVARL--QLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKH 1688

Query: 339  TIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD---ESPYIGKSRYKR 395
             +   + C K  + +  L   KI    E     P+     +++PD   E P   K++   
Sbjct: 1689 DVH--QICDKDAQQDLNLDIEKIT---ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743

Query: 396  NMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQL----EDKEKKISAAQT 451
               +  S+   +A  V +  +   E + N  + ++  +  + +L    ED+++K+ +   
Sbjct: 1744 ECISELSFSGPNA-LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802

Query: 452  RLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGRLQLVNKLRQ 510
             + EL  ++   E Q++   E   +LE+ + +LKK +          LS +L+  +   Q
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKEN--------SDLSEKLEYFSCDHQ 1854

Query: 511  EALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQ 570
            E L          Q +   +    DL++  D    +D   +  K   S KE+ LD+    
Sbjct: 1855 ELL----------QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDV---- 1900

Query: 571  YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEG---VISGLQEYLGT 627
                E+ L  I S  A    E   LE  L   Q      L+KD E    VI  L+E L  
Sbjct: 1901 ----ENELSRIRSEKASIEHEALYLEADLEVVQ-TEKLCLEKDNENKQKVIVCLEEELSV 1955

Query: 628  IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ------------------------- 662
            +  +  Q + E   +  +K T L +L+E  +E+ Q                         
Sbjct: 1956 VTSERNQLRGELDTM-SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTE 2014

Query: 663  -LEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL--EARLNLRDAEA 719
             L+ ++ D   + K+   L+  LQ   + + +L  T+ +L    A+L  E  L ++++E+
Sbjct: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074

Query: 720  NQLK---EELEKVTRLTQLEQSALQ--------AELEKERQALKNALGKAQFSEEKEQEN 768
             Q +    + EK+     LE + ++        +  ++E   L+  + K +   E + E 
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD-EK 2133

Query: 769  SELH--AKLKHLQDDNNLLKQQLKDFQNHLN-----------HVVDGLVRPEEVAARVDE 815
             +LH   KLK  + +N+ LK ++++ +  L               +     E +  +++E
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193

Query: 816  LRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEI---------LARSKWERDEAQVRE 865
            + R LK+   ++  + S  + L K + + Q Q SE+         L   K E+ E Q++E
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK-EQAEIQIKE 2252

Query: 866  RK------LQEEMALQQEKLAT--GQEEFRQACERALEARMNFDKRQHEARIQQMENEIH 917
                    LQ ++    E +A   G +E  +A E++L+  +   + +H     Q+ N I 
Sbjct: 2253 ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI---EEEH-----QLRNSIE 2304

Query: 918  YLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELK 977
             L+  L++ E+ Q     QL+E++   + +  ++  LE  ++LE A++ ++   L+ E  
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE--RELEIARTNQEHAALEAENS 2362

Query: 978  K-----LK-KAVATSDKLATAELTIA--KDQLKSLHGTVMKINQERAEELQEAER----- 1024
            K     LK K    +  L   EL +   + + ++L   + K  QER  EL+         
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK-EQERISELEIINSSFENI 2421

Query: 1025 FSRKAAQAARDLTRAEAEIELLQNLLRQKGE--------QFRLEMEKTGVGTGANSQVLE 1076
               K  +  +   ++   +E+LQ  L++  E        Q   + ++  + +      LE
Sbjct: 2422 LQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELE 2481

Query: 1077 IEKLNETMERQRTEIARLQ---NVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
              +L + ++  +     LQ   N L     D K   E   EEI+ L+ ++  Q   +S +
Sbjct: 2482 KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL 2541

Query: 1134 ADPFKRRGYW 1143
            +        W
Sbjct: 2542 SQVEGEHQLW 2551



 Score =  110 bits (276), Expect = 1e-23
 Identities = 227/1074 (21%), Positives = 449/1074 (41%), Gaps = 159/1074 (14%)

Query: 1377 VEELHRTVQKRQQQKDFIDGNVES--LMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
            VEEL    +  +Q  + ++  +ES  +M   EI++  +       E++C+ K  L    +
Sbjct: 1549 VEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQ 1608

Query: 1435 LREA-DRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV---- 1489
             ++    +  E ES+L+  K++T+    +   A+  L   +  +  L     E A+    
Sbjct: 1609 WQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRN 1668

Query: 1490 ---NLVKADQQLRSLQADAKDLEQ--HKIKQEEILKEINKIVA--------------AKD 1530
               ++ K      + +    D+ Q   K  Q+++  +I KI                + D
Sbjct: 1669 ESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPD 1728

Query: 1531 SDFQCLSKKKEKLT------------------------EELQKLQKDIEMAERNEDHHLQ 1566
            ++++   + K + +                        E++  LQ  ++         L 
Sbjct: 1729 TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH 1788

Query: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAV-------LDRQLGHKKEELHLLQGSMVQ 1619
            V+++ +  +++   E+++L S++  Q+ ++         L++ +G  K+E   L   +  
Sbjct: 1789 VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848

Query: 1620 AKADLQEALRLGETEVTEKCNHIREV---KSLLEELSFQKGELNVQISER----KTQLTL 1672
               D QE L+  ET  +E  N   E+   KS  E++     ++N    ER    + +L+ 
Sbjct: 1849 FSCDHQELLQRVET--SEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906

Query: 1673 IKQE---IEKE----EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSE 1725
            I+ E   IE E    E +L+VV  +    + + +N   ++     EL  +  + +Q   E
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE 1966

Query: 1726 LEK-----TQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
            L+      T +  L EK++ E  Q++   Q   +      ++  + E++  T   + L S
Sbjct: 1967 LDTMSKKTTALDQLSEKMK-EKTQELESHQSECLH----CIQVAEAEVKEKTELLQTLSS 2021

Query: 1781 CVECLSKEKEDLQEKCDIWEK-----------------KLAQTKRVLAAAEEN--SKMEQ 1821
             V  L K+K  LQEK    EK                 +L + K +L    E+  +++ +
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081

Query: 1822 SNLEKLE----------------LNVRKLQQELDQLNRDKLSLHNDISA-------MQQQ 1858
            S+ EKL                 L +   Q+E+ QL R    L   I A       + ++
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141

Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
            L+E+    +SL++++ N++  L +++++        +   +E   L+  I E A   +  
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201

Query: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMM---FQRLQKERESEESKL-ETSKVTLKEQ 1974
            + +  T + + + L  +I+E + +L + + +   F+ L +E+E  E ++ E SK  ++  
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261

Query: 1975 QHQLEKELTDQKSKL--DQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQ 2032
            Q+QL KEL +  + L  DQ + K  A E+ +    EEE     L  ++ + + +L   E+
Sbjct: 2262 QNQL-KELNEAVAALCGDQEIMK--ATEQSLDPPIEEE---HQLRNSIEKLRARLEADEK 2315

Query: 2033 QLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLL 2092
            + +    +L   +  AD ++     L  +    R   E        AL+ + S+ E   L
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE------HAALEAENSKGEVETL 2369

Query: 2093 EQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQME 2152
            + K E   + + +  +EL           L  EL + Q   +EL+   ++ +++ + + +
Sbjct: 2370 KAKIEG--MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427

Query: 2153 ISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMN 2212
                M+   S   + ++T LK LN+ +  L  D EA   + +NL  ++E L E     + 
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL-ELEKAQLL 2486

Query: 2213 EGPFEEKLNF----SQVH-IMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGK 2267
            +G  E K N+    S V+ ++ E   G+   EK      RLK Q+     +  E L+   
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI-----QDQEQLVSKL 2541

Query: 2268 RQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
             Q EG  H L ++ +   EL   T         L    +SL +  ++ Q+  KN
Sbjct: 2542 SQVEGE-HQLWKEQNL--ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592



 Score =  109 bits (272), Expect = 4e-23
 Identities = 196/908 (21%), Positives = 373/908 (41%), Gaps = 108/908 (11%)

Query: 276  ERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELL 335
            + D+    +  +E  ++  R L  I+++D+  +SL  E             +L++K  L 
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM-----------KELDSKLHLQ 1814

Query: 336  KQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKR 395
            + + +    AC +  ++  EL     D   E L Y+  ++ E+ +  + S  +       
Sbjct: 1815 EVQLMTKIEACIELEKIVGELKKENSDLS-EKLEYFSCDHQELLQRVETSEGLNSDLEMH 1873

Query: 396  NMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH-TPLDTQLEDKEKKISAAQTRLS 454
               ++   I D+   V     E    + N+   +R     ++ +    E  +   QT   
Sbjct: 1874 ADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKL 1933

Query: 455  ELHDEIEKAEQQILRATEEFKQL-EEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
             L  + E  ++ I+   EE   +  E  QL+       D + K+ +   QL  K++++  
Sbjct: 1934 CLEKDNENKQKVIVCLEEELSVVTSERNQLR----GELDTMSKKTTALDQLSEKMKEKTQ 1989

Query: 514  DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS------KDPKHSHMKAQKSGKEQQLDIM 567
            +LE    +    I   + E+K+    + +L S      KD  H   K Q   K+ Q   +
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049

Query: 568  NKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY--- 624
             K   +LE+++ ++        +E + L+ +L+E        + K LE  +    E+   
Sbjct: 2050 TKC--ELENQIAQLNKEKELLVKESESLQARLSESDYEKLN-VSKALEAALVEKGEFALR 2106

Query: 625  LGTIKGQATQAQNECRKLR-----DEKETL--LQRLTEVEQERDQLEIVAMDAENMRKEL 677
            L + + +  Q +    KLR     DEK+ L   ++L E E+E D L+      EN+ +EL
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD---KVENLEREL 2163

Query: 678  AELESALQEQHEVNASLQQTQGDLSAYEAELEAR---LNLRDAEANQLKEELEKVTRLTQ 734
               E   + Q  V    + ++ ++   + ++E     L + + +   L+ E E +T+  Q
Sbjct: 2164 QMSE---ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220

Query: 735  LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQN 794
             +Q  L +EL+K   + K+ L      EEKEQ   ++  + K   +   +L+ QLK+   
Sbjct: 2221 EKQGQL-SELDKLLSSFKSLL------EEKEQAEIQIKEESKTAVE---MLQNQLKE--- 2267

Query: 795  HLNHVVDGLVRPEEVAARVDE-----LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE 849
             LN  V  L   +E+    ++     +  + +L      + +  +   K    + +Q  E
Sbjct: 2268 -LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326

Query: 850  ILARSKWERDEAQVRERKL------QEEMALQQEKLATGQEEFRQACERALEAR--MNFD 901
                +   +   +  ER+L      QE  AL+ E      E  +   E   ++   +  D
Sbjct: 2327 SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELD 2386

Query: 902  KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK-----------ERILAQ 950
                 +  + + NE+   QE +  +E I    +  LQE ++EK           E +  Q
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446

Query: 951  LRELEKK-----KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLH 1005
            L+EL ++        E  K++EQ      E  +L+KA           L  AK+    L 
Sbjct: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG------LDEAKNNYIVLQ 2500

Query: 1006 GTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGE-----QFRLE 1060
             +V  + QE  +  Q+ E+   K  + +R   + + + +L+  L + +GE     +  LE
Sbjct: 2501 SSVNGLIQEVEDGKQKLEK---KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE 2557

Query: 1061 MEKTGVGTGANSQVLEIEK--LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIA- 1117
            +    V      QVL+ +   L +T+E  ++    L+N L+LT  D     E V +  A 
Sbjct: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617

Query: 1118 --ELRREV 1123
              EL+RE+
Sbjct: 2618 ETELQREM 2625



 Score =  106 bits (264), Expect = 3e-22
 Identities = 131/613 (21%), Positives = 276/613 (45%), Gaps = 90/613 (14%)

Query: 1319 HNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV- 1377
            H+ +    R+E++ + L+  +  +         S+ E+E L   I+ + Q  + LE +V 
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388

Query: 1378 ------EELHRTVQKRQQ---QKDFIDGNVESLMTELEIEK-SLKHHEDIVDEIECIEKT 1427
                  E L   +QK Q+   + + I+ + E+++ E E EK  +K       E+   +  
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448

Query: 1428 LLKRRSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
             L  R      D+   +A+     S++ C + +    ++   +AK + +  +S    L +
Sbjct: 2449 ELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ 2508

Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQ-----------HKIKQEEILKEINKIVAAKDS 1531
              ++    L K D+++  L+   +D EQ           H++ +E+ L E+  +    + 
Sbjct: 2509 EVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL-ELRNLTVELEQ 2567

Query: 1532 DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTS 1591
              Q L  K   L + L+ LQ   +  E           E E+    K + +EK+ +++T+
Sbjct: 2568 KIQVLQSKNASLQDTLEVLQSSYKNLE----------NELELTKMDKMSFVEKV-NKMTA 2616

Query: 1592 QQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
            ++ E+          + E+H     M Q  A+LQE L        EK     E++ LLEE
Sbjct: 2617 KETEL----------QREMH----EMAQKTAELQEELS------GEKNRLAGELQLLLEE 2656

Query: 1652 LSFQKG---ELNVQISERKTQLTLI-KQEIEKE-EENLQVVLRQMSKHKTELKNILDMLQ 1706
            +   K    EL ++ SE K  L  + K ++EKE +   ++   Q+  H+ E K+    L 
Sbjct: 2657 IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH--QALL 2714

Query: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766
            L+ ++   +++Q  +   +L   +  +  +KLE++ L+   ++    ++   Q+LE  K+
Sbjct: 2715 LDTNKQYEVEIQTYR--EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772

Query: 1767 E-------IERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK- 1818
                    + ++  E+   Q  ++ L K  + L+E+ +I +K+L+Q    L AA+E  K 
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQ----LQAAQEKQKT 2828

Query: 1819 --MEQSNLEKLELNVRKLQQELDQLNRDK---LSLHNDISAMQQQLQEKREAVNSLQEEL 1873
              +  + +++L   +++L++ L++  ++    L  +  +    ++L++ +E + +    L
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888

Query: 1874 ANVQDHLNLAKQD 1886
             + Q     +KQD
Sbjct: 2889 CSQQ-----SKQD 2896



 Score =  103 bits (256), Expect = 3e-21
 Identities = 188/956 (19%), Positives = 402/956 (42%), Gaps = 129/956 (13%)

Query: 248  ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
            ++ E    + + + +  E+   EE+ R +R  +    E  ++K++ T+ L++ KN   + 
Sbjct: 376  QNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV- 434

Query: 308  KSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367
                 +A L K +   +K  L    E  KQK     +A Q     E EL     + K E 
Sbjct: 435  ----LQAELDKLT--SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488

Query: 368  ---LNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
                ++   +  E+     E   I +   +   FA E    +++Q   ++ ++     + 
Sbjct: 489  NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548

Query: 425  DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLK 484
            + + L     L   + D EK+   +Q  L +    IE+   ++ +  +E K L  A++LK
Sbjct: 549  NSLTLE---KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605

Query: 485  KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK--------------- 529
            K         Y++L     L +  + E   L  QME +K+ +  K               
Sbjct: 606  KKE-------YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658

Query: 530  ----------QKEIKDLQIAI----DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLE 575
                      + + ++L + I    + LDSK  +    K      +Q+ +  ++++Q+  
Sbjct: 659  HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK-- 716

Query: 576  SRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK-----DLEGVISGLQEYLGTIKG 630
              ++ +  + ++ T +++DLE +L   Q+ +NE + K     DL      L++ L +   
Sbjct: 717  -EIENMCLKTSQLTGQVEDLEHKL---QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772

Query: 631  QATQAQNECRKLR--DEKETLLQRLTEV-------EQERDQLEIVA----MDAENMRKEL 677
                 ++  R L   D++  +      +         ER +  + A     ++  ++  +
Sbjct: 773  SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832

Query: 678  AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
              LE +L+ Q ++N+ LQ+   +L   + E+E   NL  AE        E   R+++L++
Sbjct: 833  DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEE--NLMKAEQMHQSFVAETSQRISKLQE 890

Query: 738  --SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNH 795
              SA Q  + +   AL+N   + Q   +K +      A+++ L+  N+LL+  LK+ Q  
Sbjct: 891  DTSAHQNVVAETLSALENKEKELQLLNDKVETE---QAEIQELKKSNHLLEDSLKELQ-- 945

Query: 796  LNHVVDGLVRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARS 854
                    +  E ++    E+   + L   E+  +   +  L +  A L ++   ++ +S
Sbjct: 946  --------LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKS 997

Query: 855  KWERDEAQVRERKLQE-EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQME 913
            +   +    RE+ + E     +QEKL        Q CE    A  +  ++   A  Q+  
Sbjct: 998  ESFANYIDEREKSISELSDQYKQEKLI-----LLQRCEETGNAYEDLSQKYKAA--QEKN 1050

Query: 914  NEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLD 973
            +++  L      + E   L + +  E ++ KE    + +E   K    + ++Q  +  L+
Sbjct: 1051 SKLECL------LNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE 1104

Query: 974  KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSR--KAAQ 1031
               + L+  +  +   + +E    K ++ +L     K+ +E  + LQE E+  +  K   
Sbjct: 1105 TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKH 1164

Query: 1032 AARDLTRAEAEIELLQNLLRQKGE---------QFRLEMEKTGVGTGANSQVLEIEKL-- 1080
              ++L     E E ++N ++++           Q  LE+++  + +  N+Q++++E +  
Sbjct: 1165 ECQNL-----ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS-YNAQLVQLEAMLR 1218

Query: 1081 NETMERQRTEIAR--LQNVLD-LTGSDNKGGFENV-LEEIAELRR-EVSYQNDYIS 1131
            N+ ++ Q +E  +  LQ+ L  + G       +++  +EI+ L+  E+  +  YIS
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS 1274



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 223/1147 (19%), Positives = 440/1147 (38%), Gaps = 168/1147 (14%)

Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDL------ 1366
            CN     +LE +   L+     L   +   R      ++SEKE E L H +  +      
Sbjct: 1188 CNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLET 1247

Query: 1367 --LQEKKSLE------CEVEELHRTV------QKRQQQKDFIDGNVESLMTEL-EIEKSL 1411
              LQ+ +S E      CE++   + +         Q     +  ++++ M +L E+EK  
Sbjct: 1248 SNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC 1307

Query: 1412 K----HHEDIVDEI-----ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEK 1462
            +       ++V E+     ECI  T    R    E  +LL E +     +       VE 
Sbjct: 1308 EILQAEKYELVTELNDSRSECITAT----RKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363

Query: 1463 FTDAK------------RSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQ 1510
                +             + L   +  E L    +E  ++  +  ++  SLQ++ K L  
Sbjct: 1364 IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHD 1423

Query: 1511 HKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK---------LQKDIEMAERNE 1561
               +    + E+   V +  ++   LS        +L K         L   +  +   +
Sbjct: 1424 QHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPD 1483

Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK 1621
               L  L +S       RA LE+          E AV   Q    +     LQ   +  K
Sbjct: 1484 SSSLSSLGDSSFY----RALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRK 1539

Query: 1622 ADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKG--------ELNVQISERKTQLTLI 1673
             +   A   G  E+   C   R+    LEE    +G        EL   +S  + +L  +
Sbjct: 1540 -ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL 1598

Query: 1674 KQEIEKEEENLQ-----VVLRQMSKHKTELKNILDM---LQLENHELQGLKLQHDQRVSE 1725
            +++   E E  Q     V L   SK   E K    +   L++   +LQGL L     +  
Sbjct: 1599 RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658

Query: 1726 LEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR-----EIERMTAESRALQS 1780
              +  +    E  ++         ++       Q+ ++D +     +IE++T E+ A++ 
Sbjct: 1659 DTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKIT-ETGAVKP 1717

Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRV--LAAAEENSKM------EQSNLEKLELNVR 1832
              EC  ++  D   +    +K    ++ +  L+ +  N+ +       Q ++  L+L V+
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777

Query: 1833 KLQQE--------------LDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE------- 1871
            +   E              ++ L  +   L + +   + QL  K EA   L++       
Sbjct: 1778 ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKK 1837

Query: 1872 ---ELANVQDHLNLAKQDLLHTTK-----HQDVLLSEQTRLQKDISE--------WANRF 1915
               +L+   ++ +   Q+LL   +     + D+ +      ++DI +        W  RF
Sbjct: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF 1897

Query: 1916 EDCQKEEETKQQQLQVLQNE--IEENKLKLVQQEMMFQRLQKERESEESK---LETSKVT 1970
             D + E    + +   +++E    E  L++VQ E +   L+K+ E+++     LE     
Sbjct: 1898 LDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC--LEKDNENKQKVIVCLEEELSV 1955

Query: 1971 LKEQQHQLEKELTDQKSK---LDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
            +  +++QL  EL     K   LDQ+  K+   +E+ + L+  +  C    +      ++ 
Sbjct: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKM---KEKTQELESHQSECLHCIQVAEAEVKEK 2012

Query: 2028 SEREQQLVEKSGELLA----LQKEADSMRADFSLLRNQFLTERKKAEKQVASL---KEAL 2080
            +E  Q L     ELL     LQ++  S+  D   L       + + E Q+A L   KE L
Sbjct: 2013 TELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS----LTKCELENQIAQLNKEKELL 2068

Query: 2081 KIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM 2140
              +   L+  L E   E   + K    +E    +  E A RL     ++      ++K  
Sbjct: 2069 VKESESLQARLSESDYEKLNVSK---ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125

Query: 2141 ANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGEL 2200
               +  E++Q+ I++ ++  + E  D ++  ++NL + L     + E ++   EN + E+
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERE-NDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184

Query: 2201 ESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE------DRLKAQLRH 2254
            E+LK  +            L   ++ ++      E L ++++ ++      D+L +  + 
Sbjct: 2185 ETLKTQIE------EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKS 2238

Query: 2255 CMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQ-LESSLTEDSQ 2313
             + ++ +  I+ K +++  +  L+ Q+  L E V +   D     +  Q L+  + E+ Q
Sbjct: 2239 LLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298

Query: 2314 LGQNQEK 2320
            L  + EK
Sbjct: 2299 LRNSIEK 2305



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 137/652 (21%), Positives = 290/652 (44%), Gaps = 66/652 (10%)

Query: 1649 LEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE 1708
            ++EL  Q  +L  +  +R+ QL  ++  ++K+++ ++    + +  K E + ++++   E
Sbjct: 20   IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC--E 77

Query: 1709 NHELQGLKLQHDQRVSELEKTQVAVLEEKL-----ELENLQQISQQQKGEIEWQKQLLER 1763
            + E    K+ H+ +V E   +QV   E +L     ++E L+Q  ++ K E+E  +Q  + 
Sbjct: 78   SLEKTKQKISHELQVKE---SQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQS 134

Query: 1764 DKREIERMTAESRALQSCV---ECLSKEK-EDLQEKC--DIWEKKLAQTK-RVLAAAEEN 1816
                +       +   + +   +  S  K EDL+EK   ++ E+K  + + + L A + +
Sbjct: 135  ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKAS 194

Query: 1817 SKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKRE---AVNSLQEEL 1873
              + Q+ +   ++   +    +    ++K   H  +S+  Q+   +R+   +  S ++E+
Sbjct: 195  QTLPQATMNHRDIARHQASSSVFSWQQEKTPSH--LSSNSQRTPIRRDFSASYFSGEQEV 252

Query: 1874 ANVQDHLNLAKQDL------LHTTKH-QDVLLSEQTRLQKDISEWANRFEDCQKEEETKQ 1926
               +  L + K+D         ++ H  D L ++   L+  I+E   R +  +KE + + 
Sbjct: 253  TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312

Query: 1927 QQLQVLQNEIEENKLKLVQQEMMFQRLQKE---RESEESKLETSKVTLKEQQHQLEKELT 1983
             + Q LQ ++E+ K++L+++E +  + + E     ++  +  T    L+++  +L ++L+
Sbjct: 313  NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372

Query: 1984 DQKSKLDQV-LSKVLAAEERVRTLQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
             Q+   +    S     +E+ +  QEE    +R  ++L++   Q K +L++  QQ     
Sbjct: 373  CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432

Query: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
                 LQ E D + +    L N  L E K+   +     +A +I+ ++L +++ E K+EN
Sbjct: 433  N---VLQAELDKLTSVKQQLENN-LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488

Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ----KDLERR--QME 2152
            + ++                 + + + LNQ Q    E+K +  +Q    +DL+ +  Q E
Sbjct: 489  NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548

Query: 2153 ISDAMRTLKSEVKD-------------EIRTSLKNLNQFLPELPADLEAILERNENLEGE 2199
             S  +  LK  V D             +    ++ LN  L +   + +A+L   E  + E
Sbjct: 549  NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608

Query: 2200 LESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ 2251
             E LKE            EKL      +       E L+ K+ H E  LK Q
Sbjct: 609  YEELKEEKTLFSCWKSENEKL------LTQMESEKENLQSKINHLETCLKTQ 654



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 122/637 (19%), Positives = 279/637 (43%), Gaps = 73/637 (11%)

Query: 1713 QGLKLQHDQRVSELEKTQVAVLEEK----LELENLQQISQQQKGEIEWQKQLLERDKREI 1768
            +GL  +  Q++ ELE     + +EK     +L++L+   Q+QK ++E +K      KRE 
Sbjct: 10   EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69

Query: 1769 ERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE 1828
            +R+     +L+   + +S E +  + + +  E +L   K+ +   E+  K  +S LE+ +
Sbjct: 70   QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129

Query: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQ----QQLQEKREAVNSLQEELANVQDHLNL-- 1882
               +     L+  N  +      ++  Q     + ++ +E  N   EE   ++  +    
Sbjct: 130  QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189

Query: 1883 ---AKQDLLHTT-KHQDVLL----------------------SEQTRLQKDISEWANRFE 1916
               A Q L   T  H+D+                        S++T +++D S  A+ F 
Sbjct: 190  AKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS--ASYFS 247

Query: 1917 DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQH 1976
              ++E    +  LQ+ + +   +         +  +L+ + +   +K+  +++ L+ Q H
Sbjct: 248  G-EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKI--NELELRLQGH 304

Query: 1977 QLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVE 2036
              EKE+  Q +K  ++  ++   + +V  +++        EK L++ + +L     Q  +
Sbjct: 305  --EKEMKGQVNKFQEL--QLQLEKAKVELIEK--------EKVLNKCRDELVRTTAQYDQ 352

Query: 2037 KSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQ 2096
             S +  AL+++   +  D S        +R+ AE    SL++ +K +  + ++ L  Q++
Sbjct: 353  ASTKYTALEQKLKKLTEDLS-------CQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405

Query: 2097 ENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDA 2156
                + +E   ++       ++A+ +   L     + T +K+Q+ N  +LE  + ++  A
Sbjct: 406  SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLEN--NLEEFKQKLCRA 463

Query: 2157 MRTLK-SEVKD-EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEG 2214
             +  + S++K+ E+R S++ + +    L +  E       +LE EL+++K+ L  + N  
Sbjct: 464  EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523

Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
               +  N SQ  ++ +      L+EK+  +E+ L  +    +      L K +  ++  L
Sbjct: 524  EEMKAKNTSQETMLRD------LQEKINQQENSLTLEK---LKLAVADLEKQRDCSQDLL 574

Query: 2275 HSLRRQVDALGELVTSTSADSASSPSLSQLESSLTED 2311
                  ++ L + ++ T  +S +  S  +L+    E+
Sbjct: 575  KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 152/759 (20%), Positives = 300/759 (39%), Gaps = 139/759 (18%)

Query: 405  IDSAQAVQIKKMEPDEQLRNDHMNLRGHTP---------------LDTQLEDKEKKISAA 449
            +DS +A   K+ +  E  + +  NL+                   +  +L+ KE +++  
Sbjct: 41   LDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQ 100

Query: 450  QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKI------------------SEAGK 491
            + +L+    +IEK EQ++ R   E ++ ++A Q   +                  S+   
Sbjct: 101  EGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS 160

Query: 492  DLLYKQLSGRL--QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL--QIAIDSLDS-- 545
               Y+ L  +   ++  + R EA    LQ +K  Q +       +D+    A  S+ S  
Sbjct: 161  GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220

Query: 546  --KDPKHSHMKAQK------------SGKEQ---------------------------QL 564
              K P H    +Q+            SG+++                            L
Sbjct: 221  QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280

Query: 565  DIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQ 622
            D +  Q Q+L ++++E+  R+    +E+K    +  E Q+   +A  +  + E V++  +
Sbjct: 281  DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340

Query: 623  EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
            + L     Q  QA  +   L  + + L + L+   Q  +          ++ +++ E E 
Sbjct: 341  DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC------SLEQKIKEKEK 394

Query: 683  ALQEQ-HEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ 741
              QE+      S Q    +    +A L   L       N L+ EL+K+T + Q     L+
Sbjct: 395  EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQ----QLE 450

Query: 742  AELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQ-------------- 787
              LE+ +Q L  A    Q S+ KE   +EL   ++ ++ +NNLLK               
Sbjct: 451  NNLEEFKQKLCRAEQAFQASQIKE---NELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507

Query: 788  QLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ- 846
            +LK+ +  LN   +     +      + + R L+    +       + L  ++ADL+KQ 
Sbjct: 508  ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567

Query: 847  --FSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQ 904
                ++L + +   ++   +  K ++E       L   ++E+ +  E   +   +  K +
Sbjct: 568  DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE--KTLFSCWKSE 625

Query: 905  HEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE-------EKERILAQLRELEKK 957
            +E  + QME+E   LQ  +  +E       ++  E +E       ++E +  ++R L   
Sbjct: 626  NEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH-- 683

Query: 958  KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQ--ER 1015
              + D+KS      ++ E +KL    A  +    AE +  K Q K +    +K +Q   +
Sbjct: 684  -NVLDSKS------VEVETQKL----AYMELQQKAEFSDQKHQ-KEIENMCLKTSQLTGQ 731

Query: 1016 AEELQ-EAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
             E+L+ + +  S +     R      AE E L++LL+ K
Sbjct: 732  VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 137/645 (21%), Positives = 264/645 (40%), Gaps = 98/645 (15%)

Query: 504  LVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQ 563
            L  +  Q+  +LE Q++K K       KE +  Q  +DSL++   K       +  +   
Sbjct: 12   LPTRALQKIQELEGQLDKLK-------KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64

Query: 564  LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQE 623
            L   N++  ++   L++   +I+ E  ++K+ +    EGQ+ + +   + LE  +   + 
Sbjct: 65   LKRENQRLMEICESLEKTKQKISHEL-QVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123

Query: 624  YLGTIKGQATQAQ---NECR-------------------KLRDEKETLLQRLTEVEQERD 661
             L   +  A  A    N C                    K  D KE   + +   E++R 
Sbjct: 124  ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE--ERKRL 181

Query: 662  QLEIVAMDAENMRKELAELESALQE--QHEVNASL-----QQTQGDLSAYEAELEARLNL 714
            + E+ A+ A+   + L +     ++  +H+ ++S+     ++T   LS+       R   
Sbjct: 182  EAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIR--- 238

Query: 715  RDAEANQLKEELEKVTRLTQLEQSALQA---------------ELEKERQALKNALGKAQ 759
            RD  A+    E E     + L+     A               +L+ + Q L+N + + +
Sbjct: 239  RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298

Query: 760  FS-EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRP----EEVAARVD 814
               +  E+E      K + LQ      K +L + +  LN   D LVR     ++ + +  
Sbjct: 299  LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358

Query: 815  ELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMAL 874
             L +KLK  T +++               Q+Q +E  AR   E+ + + +E++ QEE++ 
Sbjct: 359  ALEQKLKKLTEDLS--------------CQRQNAE-SARCSLEQ-KIKEKEKEFQEELSR 402

Query: 875  QQEKLATGQEEFRQACERALEARMNFDKRQH---EARIQQMENEIHYLQENLKSMEEIQG 931
            QQ    T  +E  Q   R L   +   K  H   +A + ++ +    L+ NL+  ++   
Sbjct: 403  QQRSFQTLDQECIQMKAR-LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLC 461

Query: 932  LTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQE---QVFGLDKELKKLKKAVATSDK 988
              +   Q +  ++  +   + E++K+  L  + S++   +V  L+ ELK +K+ +  S  
Sbjct: 462  RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521

Query: 989  LATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQN 1048
             A         Q   L     KINQ      QE      K   A  DL   E + +  Q+
Sbjct: 522  FAEEMKAKNTSQETMLRDLQEKINQ------QENSLTLEKLKLAVADL---EKQRDCSQD 572

Query: 1049 LLRQKG---EQFRLEMEKTGVGTGANSQVLEIEKLN-ETMERQRT 1089
            LL+++    EQ   ++ KT   + A    LE++K   E ++ ++T
Sbjct: 573  LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 149/715 (20%), Positives = 290/715 (40%), Gaps = 100/715 (13%)

Query: 435  LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ-LKKISEA---G 490
            L+ QL+  +K+    Q +L  L   ++K +Q++     E   L+   Q L +I E+    
Sbjct: 23   LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82

Query: 491  KDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLD-SKDPK 549
            K  +  +L  +   VN    +    + Q+EK +QE+   + E++  Q A  S D S +P 
Sbjct: 83   KQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142

Query: 550  HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEA 609
            ++  K   +           +Y+ L+ + ++ +    +   E+K L+ +     +     
Sbjct: 143  NTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATM 202

Query: 610  LKKDL------EGVISGLQEYLGTIKGQATQAQNECRK--LRDEKETLLQRLTEVEQERD 661
              +D+        V S  QE     K  +  + N  R    RD   +      EV   R 
Sbjct: 203  NHRDIARHQASSSVFSWQQE-----KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257

Query: 662  QLEIVAMDA---------------------ENMRKELAELESALQ-EQHEVNASLQQTQG 699
             L+I   DA                     + +R ++ ELE  LQ  + E+   + + Q 
Sbjct: 258  TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ- 316

Query: 700  DLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ-AELEKERQALKNALGKA 758
            +L     + +  L  ++   N+ ++EL + T   Q +Q++ +   LE++ + L   L   
Sbjct: 317  ELQLQLEKAKVELIEKEKVLNKCRDELVRTT--AQYDQASTKYTALEQKLKKLTEDLSCQ 374

Query: 759  QFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRR 818
            + + E  + + E   K K  +    L +QQ + FQ      +    R  +   +   +  
Sbjct: 375  RQNAESARCSLEQKIKEKEKEFQEELSRQQ-RSFQTLDQECIQMKARLTQELQQAKNMHN 433

Query: 819  KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQ---EEMALQ 875
             L+    ++        + + L +  ++F + L R++     +Q++E +L+   EEM  +
Sbjct: 434  VLQAELDKLT------SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487

Query: 876  QEKLAT-GQEEFRQAC---------ERALEARMNFDKRQHEARIQQMENEIHYLQENLKS 925
               L +  +++ R+ C         ++ L    NF   + +A+    E  +  LQE +  
Sbjct: 488  NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF-AEEMKAKNTSQETMLRDLQEKINQ 546

Query: 926  MEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVAT 985
             E    L  L+L  AD EK+R  +Q  +L KK++    +  +++   +KE K L  A   
Sbjct: 547  QENSLTLEKLKLAVADLEKQRDCSQ--DLLKKREHHIEQLNDKLSKTEKESKALLSA--- 601

Query: 986  SDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER-FSRKAAQAARDLTRAEAEIE 1044
                                   +++ ++  EEL+E +  FS   ++  + LT+ E+E E
Sbjct: 602  -----------------------LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE 638

Query: 1045 LLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
             LQ+ +       + +  K+      N +V  +E   E +     EI  L NVLD
Sbjct: 639  NLQSKINHLETCLKTQQIKS---HEYNERVRTLEMDRENLS---VEIRNLHNVLD 687



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 163/780 (20%), Positives = 325/780 (41%), Gaps = 81/780 (10%)

Query: 244  LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ 303
            L +LE+ E +     D+ E  E+  ++E+++    LE  + E + L    +   +E+ + 
Sbjct: 903  LSALENKEKELQLLNDKVET-EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI 961

Query: 304  DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
              LNK   EE   +  + +E+ + LN +   L QK+        ++ +   EL+      
Sbjct: 962  ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE 1021

Query: 364  KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
            K   L        E   A ++     K+  ++N    E  + +     + +K E  EQL+
Sbjct: 1022 KLILL----QRCEETGNAYEDLSQKYKAAQEKNS-KLECLLNECTSLCENRKNEL-EQLK 1075

Query: 424  NDHMNLRGHTPLDTQL---EDKEKKI-----SAAQTRLSELHDEIEKAEQQILRATEEFK 475
                  + H    T+L   E++ + +     +  Q   SE+ D    ++ +     +E  
Sbjct: 1076 EAF--AKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIM 1133

Query: 476  QLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQ------MEKQKQEIAGK 529
             L+E  +  K+ +   DLL  Q + +L  V K + E  +LE +       E++ +     
Sbjct: 1134 TLKE--EQNKMQKEVNDLL--QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCN 1189

Query: 530  QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
             K   DL++   SLDS + +   ++A    KE +L    K+ + L+  L  I   +  ET
Sbjct: 1190 FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL--ET 1247

Query: 590  EEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649
              ++D++ Q   G         KD E  I   ++Y+     + + +QN+   L+   +T 
Sbjct: 1248 SNLQDMQSQEISG--------LKDCE--IDAEEKYISG-PHELSTSQNDNAHLQCSLQTT 1296

Query: 650  LQRLTEVEQ-----ERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAY 704
            + +L E+E+     + ++ E+V    ++  + +       +E  ++   ++    D    
Sbjct: 1297 MNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLL 1356

Query: 705  EAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK 764
              EL    ++   E  +   E   V+ L  L++S        E   L +   +  F+E +
Sbjct: 1357 HGELVE--DIPGGEFGEQPNEQHPVS-LAPLDESN-----SYEHLTLSDKEVQMHFAELQ 1408

Query: 765  EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV-VDGLVRPEEVAARVDELRRKLKLG 823
            E+  S L ++ K L D +  +  ++ + Q +++ +  + LV    +     +L ++++LG
Sbjct: 1409 EKFLS-LQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLG 1467

Query: 824  TGEMNIHS------PSDVLGKSLAD------LQKQFSEILARSKWE----RDEAQVRE-- 865
              E  + S      P      SL D      L +Q  ++   S  E     ++  V E  
Sbjct: 1468 LEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVF 1527

Query: 866  -RKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
               LQEE   ++E     A G EE    CE   ++    +++     I +   EI  L++
Sbjct: 1528 CSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK-NKEIQELEQ 1586

Query: 922  NLKS-MEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLK 980
             L S  +E+  L    L E ++ ++++ +   E+E K   E  K Q +   L+ E+ +L+
Sbjct: 1587 LLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAE--KKQTEQLSLELEVARLQ 1644


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.127    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,398,281
Number of Sequences: 37866
Number of extensions: 4313798
Number of successful extensions: 79412
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 828
Number of HSP's successfully gapped in prelim test: 2010
Number of HSP's that attempted gapping in prelim test: 21452
Number of HSP's gapped (non-prelim): 24367
length of query: 2325
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2206
effective length of database: 13,741,464
effective search space: 30313669584
effective search space used: 30313669584
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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