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Search of human proteins with 87298937
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|87298937 centrosomal protein 110kDa [Homo sapiens]
(2325 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 4489 0.0
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 198 6e-50
gi|21735548 centrosomal protein 2 [Homo sapiens] 182 3e-45
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 180 1e-44
gi|71061468 centromere protein E [Homo sapiens] 180 2e-44
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 177 1e-43
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 177 1e-43
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 177 1e-43
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 177 1e-43
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 174 9e-43
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 173 2e-42
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 173 2e-42
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 170 2e-41
gi|156104908 myosin heavy chain 6 [Homo sapiens] 169 3e-41
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 168 6e-41
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 167 8e-41
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 164 9e-40
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 164 1e-39
gi|4506751 restin isoform a [Homo sapiens] 162 5e-39
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 161 6e-39
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 159 2e-38
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 159 3e-38
gi|50083279 centrosome protein 4 [Homo sapiens] 159 4e-38
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 157 9e-38
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 157 9e-38
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 157 1e-37
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 157 1e-37
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 157 1e-37
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 157 1e-37
gi|55770834 centromere protein F [Homo sapiens] 157 1e-37
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 4489 bits (11643), Expect = 0.0
Identities = 2325/2325 (100%), Positives = 2325/2325 (100%)
Query: 1 MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD 60
MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD
Sbjct: 1 MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD 60
Query: 61 ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN 120
ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN
Sbjct: 61 ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN 120
Query: 121 LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE 180
LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE
Sbjct: 121 LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE 180
Query: 181 IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT 240
IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT
Sbjct: 181 IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT 240
Query: 241 IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI 300
IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI
Sbjct: 241 IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI 300
Query: 301 KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK
Sbjct: 301 KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
Query: 361 IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE 420
IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE
Sbjct: 361 IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE 420
Query: 421 QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA 480
QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA
Sbjct: 421 QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA 480
Query: 481 IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI 540
IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI
Sbjct: 481 IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI 540
Query: 541 DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT 600
DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT
Sbjct: 541 DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT 600
Query: 601 EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER
Sbjct: 601 EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
Query: 661 DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720
DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN
Sbjct: 661 DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720
Query: 721 QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780
QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD
Sbjct: 721 QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780
Query: 781 DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL 840
DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL
Sbjct: 781 DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL 840
Query: 841 ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF
Sbjct: 841 ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
Query: 901 DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL 960
DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL
Sbjct: 901 DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL 960
Query: 961 EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ
Sbjct: 961 EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
Query: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL 1080
EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL
Sbjct: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL 1080
Query: 1081 NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140
NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR
Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140
Query: 1141 GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW 1200
GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW
Sbjct: 1141 GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW 1200
Query: 1201 VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM 1260
VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM
Sbjct: 1201 VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM 1260
Query: 1261 ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN 1320
ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN
Sbjct: 1261 ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN 1320
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
Query: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 1560
LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN
Sbjct: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 1560
Query: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620
EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA
Sbjct: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620
Query: 1621 KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE
Sbjct: 1621 KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
Query: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
Query: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
Query: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK 1920
EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK
Sbjct: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK 1920
Query: 1921 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1980
EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK
Sbjct: 1921 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1980
Query: 1981 ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE 2040
ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE
Sbjct: 1981 ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE 2040
Query: 2041 LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC 2100
LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC
Sbjct: 2041 LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC 2100
Query: 2101 IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL 2160
IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL
Sbjct: 2101 IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL 2160
Query: 2161 KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL 2220
KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL
Sbjct: 2161 KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL 2220
Query: 2221 NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ
Sbjct: 2221 NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
Query: 2281 VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR
Sbjct: 2281 VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 198 bits (503), Expect = 6e-50
Identities = 248/1086 (22%), Positives = 474/1086 (43%), Gaps = 138/1086 (12%)
Query: 1322 ENEVSRLEDIMQHLKSKK--------------REERWMRASKRQSEKEMEELHHNIDDLL 1367
EN ++ +E + L ++K E +RA ++E+EE+ H+++ +
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924
Query: 1368 QEKKS----LECEVEELHRTVQKRQQQKDFIDG-----NVESLMTELEIEKSLKHHEDIV 1418
+E++ L+ E +++ + +Q+ ++Q + + +E + TE +++K L+ + I+
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK-LEEEQIIL 983
Query: 1419 DEIEC---IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE-KFTDAKRSLLQTE 1474
++ C EK LL+ R + E L E E E S + K KN E TD + L + E
Sbjct: 984 EDQNCKLAKEKKLLEDR--IAEFTTNLTE-EEEKSKSLAKLKNKHEAMITDLEERLRREE 1040
Query: 1475 SDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQ 1534
+ELE+ ++ + Q+ LQA +L+ K+EE L+ V + +
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 1535 CLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQ 1594
KK +L ++ +LQ+D+E + + + ++ L+A + ELE +QQ+
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 1595 EMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE--- 1651
+ ++++ K+ L + ++++ E+ E+ + VK+ LE+
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 1652 -LSFQKGELNVQIS---ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQL 1707
L ++GEL ++ + K ++++E + + LQV + + +TEL + + LQ+
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 1708 ENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKRE 1767
E + GL Q D + S+L K A+ + + + L Q +QK + + + +E +K
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Query: 1768 I-ERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEK 1826
E++ E A + L K+ L + +KK+ + L AEE + Q +LE
Sbjct: 1341 FREQLEEEEEAKHN----LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 1827 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
L + D+L + K L ++ + L +R++ +L+++
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK-------------- 1442
Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
K D LL+E+ + +E +R E +E+ETK L E E K +L
Sbjct: 1443 ----QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL--- 1495
Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
+RL K+ +E L +SK + + H+LEK + +++++ +++ E+ ++
Sbjct: 1496 ----ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Query: 2007 QEEERWCE-SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTE 2065
++ + E +L+ +Q +R L R++Q EK +L+ +E ++ D R+ +
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 2066 RKKAE---------------------KQVASLKEALKIQRSQLE------KNLLEQKQEN 2098
RKK E KQ+ L+ +K +L+ + +L Q +EN
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671
Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL------ERRQME 2152
K M + Q+ A R + Q Q E EL ++AN E+R++E
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKR---QAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 2153 ISDAMRTLKSEVKDE------IRTSLKNLNQFLPELPADL---EAILERNENLEGELESL 2203
A L+ E+++E I LK N + ++ DL + ++NEN +LE
Sbjct: 1729 ARIAQ--LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1786
Query: 2204 KENLPFTMN--EGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAE 2261
+ L + EG + K S AL K+ E++L + +K+ +
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASIT----------ALEAKIAQLEEQLDNE-----TKERQ 1831
Query: 2262 VLIKGKRQTEGTLHSLRRQVD--ALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQE 2319
K R+TE L + QVD AD AS+ L QL+ L E + + Q
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST-RLKQLKRQLEEAEE--EAQR 1888
Query: 2320 KNASAR 2325
NAS R
Sbjct: 1889 ANASRR 1894
Score = 139 bits (350), Expect = 3e-32
Identities = 211/963 (21%), Positives = 423/963 (43%), Gaps = 133/963 (13%)
Query: 251 EGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSL 310
E + V +++Q A E L E+E L+ L + ++ +E +T E ++L L
Sbjct: 851 EEELVKVREKQLAAEN-RLTEMETLQSQLMAEKLQLQEQLQAETELCAEA---EELRARL 906
Query: 311 KEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNY 370
+ ++ C +L++ + + E + E + Q ELE++L + + L
Sbjct: 907 TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 371 YPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLR 430
+E A++ K +E + K A E +++ A + +E+ L+
Sbjct: 967 VTTE-AKLKKLEEEQIILEDQNCK---LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 431 G-HTPLDTQLEDKEKKISAAQTRL-----------SELHDEIEKAEQQILRATEEFKQLE 478
H + T LE++ ++ + L ++L D+I + + QI + + E
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082
Query: 479 EAIQ--LKKISE--AGKDLLYKQLSGRLQLVNKLRQEALDLEL----QMEKQKQEIAGKQ 530
E +Q L ++ E A K++ K++ +++L QE L+ E + EKQK+++ +
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRNKAEKQKRDLGEEL 1141
Query: 531 KEIK-DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY-QQLESRLDEILSRIAKE 588
+ +K +L+ D+LDS + + +S +EQ+++I+ K ++ ++ +I K
Sbjct: 1142 EALKTELE---DTLDST----AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
++ +++L EQL + + V + L++ T++ + + NE + L K
Sbjct: 1195 SQAVEELAEQL------------EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQ-EQHEVNASLQQTQG-------D 700
+ +VE + +L++ + E +R ELA+ + LQ E V L Q+ D
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 701 LSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQF 760
SA E++L+ L E N+ K L + + E+++ + +LE+E +A N
Sbjct: 1303 FSALESQLQDTQELLQ-EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL------ 1355
Query: 761 SEEKEQENSELHAK---LKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEVAARVDEL 816
E++ + LHA+ +K +D+ + ++ + L ++GL R EE A D+L
Sbjct: 1356 ----EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411
Query: 817 RR-KLKLGTGEMNIHSPSDVLGKSLADL---QKQFSEILARSKW---------ERDEAQV 863
+ K +L ++ D +S +L QK+F ++LA K +R EA+
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471
Query: 864 RERKLQ--------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQH---------E 906
RE++ + EE Q+ +L ++FR E + ++ + K H E
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 907 ARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERIL-AQLRELEKKKKLEDAKS 965
++++M+ ++ L++ L++ E+ + ++ LQ + ER L + + E+KKK +
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 966 QEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERF 1025
+E L+ E K+ AVA KL + LK L + N+ R E +++ +
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKL--------EMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 1026 SRKAAQAARDL--TRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
+ R+L TRA E E+L + + +E E + ++ E+
Sbjct: 1644 QAQMKDCMRELDDTRASRE-EILAQAKENEKKLKSMEAEMIQL----QEELAAAERAKRQ 1698
Query: 1084 MERQRTEIARLQNVLDLTGSDNKGGFENVLEE-------IAELRREVSYQNDYISSMADP 1136
+++R E+A ++ S KG LEE IA+L E+ + + D
Sbjct: 1699 AQQERDELAD-----EIANSSGKGAL--ALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 1137 FKR 1139
K+
Sbjct: 1752 LKK 1754
Score = 132 bits (333), Expect = 3e-30
Identities = 209/915 (22%), Positives = 385/915 (42%), Gaps = 156/915 (17%)
Query: 244 LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ 303
L+ + LE Q Q+ E+ ER S + E+ +RDL + E E LK++ L+ Q
Sbjct: 1103 LKKIRELESQISELQEDLES-ERASRNKAEKQKRDLGE---ELEALKTELEDTLDSTAAQ 1158
Query: 304 DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
+L ++E + K++ EE + + ++QK + +Q E + + A
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
K + L E A K + G S +KR + Q +Q+K E E++R
Sbjct: 1219 K-QTLENERGELANEVKVLLQGK--GDSEHKRKKVEAQ------LQELQVKFNE-GERVR 1268
Query: 424 ND--------HMNLRGHTPLDTQLEDKEKKI----SAAQTRLSELHDEIEKAEQQILRAT 471
+ + L T L +Q + K K+ SA +++L + + +++ +Q L +
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLS 1328
Query: 472 EEFKQLEEAI-----QLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQME------ 520
+ KQ+E+ QL++ EA K L KQ++ L + D++ +ME
Sbjct: 1329 TKLKQVEDEKNSFREQLEEEEEA-KHNLEKQIA-------TLHAQVADMKKKMEDSVGCL 1380
Query: 521 KQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLD--IMNKQYQQL---- 574
+ +E+ K+K KDL+ + K + ++ K+ +Q+LD +++ +Q+
Sbjct: 1381 ETAEEV--KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 575 ----ESRLDEILSRIAKETEEIKDLEEQ-LTEGQIAANEALKKDLEGVISGLQEYLGTIK 629
+ + D++L+ ++T K EE+ E + E L + E ++
Sbjct: 1439 LEKKQKKFDQLLAE--EKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 630 GQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE 689
Q + E L K+ + + + E+E+ + LE E M+ +L ELE LQ +
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE---QQVEEMKTQLEELEDELQATED 1553
Query: 690 VNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
L+ +L A +A+ E L RD ++ + K++L + R ++AELE ER+
Sbjct: 1554 AKLRLEV---NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR-------EMEAELEDERK 1603
Query: 750 ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL-----LKQQLKDFQNHLNHVVDGLV 804
A+ A+ E + ++ E H + D + L+ Q+KD L+ D
Sbjct: 1604 QRSMAVA-ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELD---DTRA 1659
Query: 805 RPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
EE+ A+ E +KLK EM Q E LA ++ + +AQ
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMI-----------------QLQEELAAAERAKRQAQQE 1702
Query: 865 ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLK 924
+L +E+A K A EE KR+ EARI Q+E E+ Q N +
Sbjct: 1703 RDELADEIANSSGKGALALEE----------------KRRLEARIAQLEEELEEEQGNTE 1746
Query: 925 ---------SMEEIQGLTDLQLQEADEEKERILAQLRELEKKK---KLED------AKSQ 966
+++ Q TDL L+ + +K Q E + K+ KL++ +K +
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 967 EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ---EAE 1023
+ L+ ++ +L++ + K A + K L +++++ ER Q +A+
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Query: 1024 RFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
+ S + Q R L AE E Q+ R ++++ E+E ET
Sbjct: 1867 KASTRLKQLKRQLEEAEEE--------AQRANASRRKLQR------------ELEDATET 1906
Query: 1084 MERQRTEIARLQNVL 1098
+ E++ L+N L
Sbjct: 1907 ADAMNREVSSLKNKL 1921
Score = 127 bits (319), Expect = 1e-28
Identities = 171/789 (21%), Positives = 338/789 (42%), Gaps = 94/789 (11%)
Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEK-------KSLECEVEEL 1380
+E++ + L+ KR + + +K+ E E EL + + LLQ K K +E +++EL
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
+ ++ + + V L EL+ L D + + K S+L++
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD--SKSSKLTKDFSALESQLQDTQE 1315
Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
LL E + K K ++ + L + E LE++ + +++
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA--- 1557
+ E+ K K ++ L+ +++ K + + L K K +L +EL L D++
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 1558 ----ERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
E+ + Q+L E E + AK AE E+ +++ ++++E L L EE
Sbjct: 1436 ACNLEKKQKKFDQLLAE-EKTISAKYAE-ERDRAEAEAREKETKALS--LARALEEA--- 1488
Query: 1614 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLI 1673
++ KA+L+ + TE+ + + +V + EL K L Q+ E KTQL +
Sbjct: 1489 ----MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 1674 KQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAV 1733
+ E++ E+ +K + E+ N+ M +LQG Q +++ +L + QV
Sbjct: 1545 EDELQATED---------AKLRLEV-NLQAMKAQFERDLQGRDEQSEEKKKQLVR-QVRE 1593
Query: 1734 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-RMTAESRALQSCVECLSKEKEDL 1792
+E +LE E ++Q+ ++ LE D +++E + + ++ ++ L K + +
Sbjct: 1594 MEAELEDE------RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 1793 QEKCDIWEKKLAQTKRVLAAAEENSK----ME------QSNLEKLELNVRKLQQELDQLN 1842
++ + A + +LA A+EN K ME Q L E R+ QQE D+L
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL- 1706
Query: 1843 RDKLSLHNDISAMQQQLQEKREA-VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
D+++ + A+ + + + EA + L+EEL Q + L L D +
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI---N 1763
Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN------------KLKLVQQEMM 1949
T L + S A + E+ +++ E + ++L+V E+E + K+ Q E
Sbjct: 1764 TDLNLERSH-AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 1950 FQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE 2009
KER++ ++ ++ LK+ Q++ E + + DQ ++ R L+E
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 2010 ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ-------F 2062
E + + + +R+L + + AD+M + S L+N+ F
Sbjct: 1883 EEEAQRANASRRKLQRELEDATE--------------TADAMNREVSSLKNKLRRGDLPF 1928
Query: 2063 LTERKKAEK 2071
+ R+ A K
Sbjct: 1929 VVPRRMARK 1937
Score = 108 bits (270), Expect = 6e-23
Identities = 125/662 (18%), Positives = 302/662 (45%), Gaps = 49/662 (7%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
S+L+D + L+ + R++ + +Q E E +++ + K +LE ++ LH V
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLK--------HHEDIVDEIECIEKTLLKRRSELRE 1437
+++ ++ +V L T E+++ L+ HE+ V + +EKT + + EL
Sbjct: 1368 DMKKK---MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL-- 1422
Query: 1438 ADRLLAEAESEL--SCTKEKTKNAVEKFTDAKRSL---LQTESDAEELERRAQET-AVNL 1491
D LL + + + +C EK + ++ ++++ E D E E R +ET A++L
Sbjct: 1423 -DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 1492 VKADQQLRSLQADAKDL-EQHKIKQEEILK---EINKIVAAKDSDFQCLSKKKEKLTEEL 1547
+A ++ +A+ + L +Q + + E+++ ++ K V + + L ++ E++ +L
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 1548 QKLQKDIEMAERNE---DHHLQVLK-ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQL 1603
++L+ +++ E + + +LQ +K + E LQ + + E+ K Q+ Q +EM + +L
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM---EAEL 1598
Query: 1604 GHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQI 1663
++++ + + + + DL++ ++ + I++++ L ++ EL+
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRV 1723
+ R+ L K+ EK+ ++++ + Q+ + + Q E EL D+
Sbjct: 1659 ASREEILAQAKEN-EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA------DEIA 1711
Query: 1724 SELEKTQVAVLEEKLELE----NLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
+ K +A LEEK LE L++ ++++G E L++ +I+++ + +
Sbjct: 1712 NSSGKGALA-LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1770
Query: 1780 SCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD 1839
S + ++ L+ + + KL + + + SK + S + LE + +L+++LD
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTV-----KSKYKAS-ITALEAKIAQLEEQLD 1824
Query: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
+++ + + +++L++ V+ + +D + A L + +
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
Query: 1900 EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERES 1959
E R + ED + + +++ L+N++ L V M ++ +
Sbjct: 1885 EAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSD 1944
Query: 1960 EE 1961
EE
Sbjct: 1945 EE 1946
Score = 107 bits (268), Expect = 1e-22
Identities = 120/536 (22%), Positives = 246/536 (45%), Gaps = 54/536 (10%)
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNR--DKLSLHNDISAMQ 1856
W + + K +L S+ E+ + K E V+ +++L NR + +L + + A +
Sbjct: 827 WWRLFTKVKPLLQV----SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEK 882
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
QLQE+ +A L E ++ L KQ+L +++ + R++++ R +
Sbjct: 883 LQLQEQLQAETELCAEAEELRARLTAKKQEL------EEICHDLEARVEEE----EERCQ 932
Query: 1917 DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKER---ESEESKLETSKVTLKE 1973
Q E++ QQ +Q L+ ++EE +E Q+LQ E+ E++ KLE ++ L++
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEE-------EESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL----QEEERWCESLEKTLSQTKRQLSE 2029
Q +L KE + ++ + + + EE+ ++L + E LE+ L + ++Q E
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 2030 REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEK 2089
E+ + G+ L + ++A + L+ Q + ++ + +A ++E Q++ K
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE-AAQKNMALK 1104
Query: 2090 NLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL-ER 2148
+ E + + S +Q+++ + ++ R L +EL ++ E + A Q++L +
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 2149 RQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLP 2208
R+ E++ +TL+ E K ++ + Q + +L LE+ + ++ LE K+ L
Sbjct: 1165 REQEVNILKKTLEEEAKTH-EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 2209 FTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKR 2268
E E K+ +G++ H+ +++AQL+ K E G+R
Sbjct: 1224 NERGELANEVKVLL--------QGKGDS-----EHKRKKVEAQLQELQVKFNE----GER 1266
Query: 2269 -QTEGTLHSLRRQVD---ALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEK 2320
+TE + QV+ G L S S S + S LES L + +L Q + +
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Score = 100 bits (250), Expect = 1e-20
Identities = 171/774 (22%), Positives = 305/774 (39%), Gaps = 162/774 (20%)
Query: 466 QILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSG--RLQLVNKLRQEALDLELQMEKQK 523
Q+ R EE EE +L K+ E KQL+ RL + L+ + + +LQ+++Q
Sbjct: 839 QVSRQEEEMMAKEE--ELVKVRE-------KQLAAENRLTEMETLQSQLMAEKLQLQEQL 889
Query: 524 QEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILS 583
Q E ++L+ + + A+K E+ + + ++ E R + +
Sbjct: 890 QAETELCAEAEELR-------------ARLTAKKQELEEICHDLEARVEEEEERCQHLQA 936
Query: 584 RIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIKGQATQAQNECRK 641
K + I++LEEQL E + A + K E + L+E ++ Q + E +
Sbjct: 937 EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 996
Query: 642 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQT---- 697
L D LTE E++ L + E M + +LE L+ + + L++T
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQRQELEKTRRKL 1053
Query: 698 QGD---------------------LSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLE 736
+GD L+ E EL+A L + EA Q L+K+ L + +
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL-ESQ 1112
Query: 737 QSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD--DNNLLKQQLKDFQN 794
S LQ +LE ER + A ++K EL A L+D D+ +Q+L+ +
Sbjct: 1113 ISELQEDLESERASRNKA------EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 795 HLNHVVDGLVRPEEVA--ARVDELRRKLKLGTGEM------------NIHSPSDVLGKSL 840
+++ + E A++ E+R+K E+ N+ L
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 841 ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
+L + +L + +++ + +K++ ++ Q K G+ + ++ + ++
Sbjct: 1227 GELANEVKVLLQ----GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 901 DK----------------RQHEARIQQMENEIHYLQE----------NLKSMEEIQGLTD 934
D + A Q+++ LQE LK +E+ +
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 935 LQLQEADEEKERILAQLREL-----EKKKKLEDA-----KSQEQVFGLDKELKKL----K 980
QL+E +E K + Q+ L + KKK+ED+ ++E L K+L+ L +
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 981 KAVATSDKL-------------ATAELTIAKDQLKSLHGTVMKINQERAEE----LQEAE 1023
+ VA DKL +L + +L K +Q AEE + AE
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 1024 RFSRKAAQAARDLTRAEAEIELLQNLLRQKGE------QFRLEME-----KTGVGTGANS 1072
R A+A T+A + L+ + QK E QFR EME K VG +
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 1073 QVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
L + +E +T++ L++ L T E A+LR EV+ Q
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQAT-------------EDAKLRLEVNLQ 1563
Score = 100 bits (250), Expect = 1e-20
Identities = 170/727 (23%), Positives = 315/727 (43%), Gaps = 132/727 (18%)
Query: 155 SYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRV--------LNLKGNKIS 206
S +K K+E LQ+L + NE E + L K+ L+V L+ +K S
Sbjct: 1243 SEHKRKKVEA-----QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 207 SL-QDISKLKP-LQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAF 264
L +D S L+ LQD L+ EN R SL + +D + +F
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEEN----------------RQKLSLSTKLKQVEDEKNSF 1341
Query: 265 ERFSLEEVERLERDLEKKMI----ETEELKSKQTRFL------EEIKNQDKLNKSLK--- 311
R LEE E + +LEK++ + ++K K + EE+K KL K L+
Sbjct: 1342 -REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR--KLQKDLEGLS 1398
Query: 312 ---EEAMLQKQSCEELKSDLNTK-NELLKQKTIELTRAC---QKQYELEQELAFYK-IDA 363
EE + E+ K+ L + ++LL + AC +KQ + +Q LA K I A
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
K+ E D+A E+ R K + + ++ A + + ++Q R
Sbjct: 1459 KYAE---------ERDRAEAEA------REKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 424 NDHMNLRGHTP-LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ 482
+ +L + + + EK A + ++ E+ ++E+ E + L+ATE+ K ++
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE-LQATEDAK-----LR 1557
Query: 483 LKKISEAGKDLLYKQLSGR--------LQLVNKLRQEALDLELQMEKQKQEIAGKQK--- 531
L+ +A K + L GR QLV ++R+ +LE + +++ +A ++K
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617
Query: 532 EIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
++KDL+ IDS + + +K + + Q D M + SR +EIL++ + ++
Sbjct: 1618 DLKDLEAHIDSANKN--RDEAIKQLRKLQAQMKDCMRELDDTRASR-EEILAQAKENEKK 1674
Query: 592 IKDLEEQLTEGQ--IAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649
+K +E ++ + Q +AA E K+ + L + + G+ A E R+L L
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQL 1734
Query: 650 LQRLTEVEQERD-----------QLEIVAMDAENMRKELAELESALQ----EQHEVNASL 694
+ L E + + Q++ + D R + E+A Q + E+ L
Sbjct: 1735 EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794
Query: 695 QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA 754
Q+ +G + +++ +A + +A+ QL+E+L+ T+ E+ A ++ + + LK+
Sbjct: 1795 QEMEGTV---KSKYKASITALEAKIAQLEEQLDNETK----ERQAACKQVRRTEKKLKDV 1847
Query: 755 LGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVD 814
L + E+ N+E + +D + +LK + L EE A R +
Sbjct: 1848 L----LQVDDERRNAEQY------KDQADKASTRLKQLKRQLEEA-------EEEAQRAN 1890
Query: 815 ELRRKLK 821
RRKL+
Sbjct: 1891 ASRRKLQ 1897
Score = 88.2 bits (217), Expect = 9e-17
Identities = 113/506 (22%), Positives = 225/506 (44%), Gaps = 70/506 (13%)
Query: 1320 NLENEVSRLEDIMQHLKS---KKREER-WMRASKRQSEKEMEELHHNIDDLLQEKKSLE- 1374
NLE + + + ++ K+ K EER A R+ E + L +++ +++K LE
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497
Query: 1375 ------CEVEELH-------RTVQKRQQQKDFIDGNVESLMTELE-IEKSLKHHEDIVDE 1420
E+E+L ++V + ++ K ++ VE + T+LE +E L+ ED
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557
Query: 1421 IEC--------IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQ 1472
+E E+ L R + E + L E+ E + A++ L
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-- 1615
Query: 1473 TESDAEELERRAQETAVNLVKADQQLRSLQADAKD----LEQHKIKQEEILKEINKIVAA 1528
E D ++LE N +A +QLR LQA KD L+ + +EEIL + A
Sbjct: 1616 -EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ------A 1668
Query: 1529 KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQ 1588
K+++ KK + + E+ +LQ+++ AER + Q +E + L E+ +
Sbjct: 1669 KENE-----KKLKSMEAEMIQLQEELAAAERAKR---QAQQERDELAD----EIANSSGK 1716
Query: 1589 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEA-LRLGE--TEVTEKCNHIREV 1645
+E L+ ++ +EEL QG+ L++A L++ + T++ + +H ++
Sbjct: 1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN 1776
Query: 1646 KSLLEELSFQKGELNVQISER--------KTQLTLIKQEIEKEEENL-------QVVLRQ 1690
++ ++L Q EL V++ E K +T ++ +I + EE L Q +Q
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836
Query: 1691 MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQ 1750
+ + + +LK++L + E + K Q D+ + L++ + + E + E + ++
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
Query: 1751 KGEIEWQKQLLERDKREIERMTAESR 1776
+ E+E + + RE+ + + R
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLR 1922
Score = 38.9 bits (89), Expect = 0.059
Identities = 52/226 (23%), Positives = 107/226 (47%), Gaps = 28/226 (12%)
Query: 888 QACERALEARMNFDKRQHEARIQQM--ENEIHYLQ----ENLKSMEEIQGLTDLQLQEAD 941
QAC R AR F KRQ + ++ N YL+ + + +++ L + QE +
Sbjct: 787 QACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEE 846
Query: 942 ---EEKERILAQLRELEKKKKLEDAKS-QEQVFG----LDKELKKLKKAVATSDKLATAE 993
+E+E + + ++L + +L + ++ Q Q+ L ++L+ + A +++L A
Sbjct: 847 MMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL-RAR 905
Query: 994 LTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
LT K +L+ + + +E E Q + +K Q + EL + L ++
Sbjct: 906 LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ---------ELEEQLEEEE 956
Query: 1054 GEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
+ +L++EK V T A + LE E++ +E Q ++A+ + +L+
Sbjct: 957 SARQKLQLEK--VTTEAKLKKLEEEQI--ILEDQNCKLAKEKKLLE 998
Score = 35.8 bits (81), Expect = 0.50
Identities = 53/281 (18%), Positives = 115/281 (40%), Gaps = 34/281 (12%)
Query: 245 RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQD 304
+ L+S+E + + Q+ A ER + +++ ++ E K LEE + +
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAK----RQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 305 KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
L+EE ++ + E + L N + Q +L ++ + + E A +++ +
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN--LERSHAQKNENARQQLERQ 1786
Query: 365 FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
+ E+ E KS+YK ++ A E+ I + +EQL N
Sbjct: 1787 NK----------ELKVKLQEMEGTVKSKYKASITALEAKIA-----------QLEEQLDN 1825
Query: 425 DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL----EEA 480
+ + Q+ EKK+ ++ + E+ + Q +A+ KQL EEA
Sbjct: 1826 ETKERQAACK---QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 481 IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEK 521
+ + + A + L ++L + + + +E L+ ++ +
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 182 bits (463), Expect = 3e-45
Identities = 215/981 (21%), Positives = 425/981 (43%), Gaps = 102/981 (10%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
+ L+D+ + L + E+ + E E+ ELH + L + E + E +
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
Q K+ + VE L + ++ I++E ++ LK ++E E++R A+A
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 1446 ESELSCTKEKTKNAV-EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQAD 1504
E K A+ E ++L + E + E L + QE L L D
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
Query: 1505 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLT---EELQKLQKDIEMAERNE 1561
K Q Q+E ++E+ K + + + ++++KLT E++++L+KD E
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524
Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK 1621
+H L L++ + +++++R +++ LK Q+ + E L+ + H K E Q +++
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTL--ECLALELEENHHKMEC---QQKLIKEL 1579
Query: 1622 ADLQEALRLGETEVT----EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
+E R+ T +T E+ ++ S + +L L ++ ER QE+
Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD-------QEV 1632
Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS----ELEKTQVAV 1733
+ + E ++ + RQ +L+ L L+ +Q L+ Q ++ +LE+ ++++
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692
Query: 1734 LEEKLELENLQQISQQQ----KGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEK 1789
E EL +Q+ Q++ KG + Q+ LE K + E Q + L + K
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKL----ELNVRKLQQELDQLNRDK 1845
+ L+++ +K+ +T +L+ E+ + Q L++ EL + LQ +LD+ R
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL 1812
Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
++ A+QQ+ Q+ + ++E+ +Q L A H T L E+
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA-----HMT------LKERHGEL 1861
Query: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE 1965
+D E A R E+ E + +++Q L+ + + + + +QE LQ++ + + E
Sbjct: 1862 QDHKEQARRLEE---ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
Query: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE--ERWCESLEKTLSQT 2023
L++ Q + L ++ +L+ L AE + QEE E+L++ L +
Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELE-----ALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
L +EQ L+E++ +L+ +++A + L+EAL+IQ
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEASTATLQASLDA-----------CQAHSRQLEEALRIQ 2022
Query: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ 2143
+++ L +++ +Q+ +A + + ER + L K L Q E +KQ Q
Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ 2082
Query: 2144 KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESL 2203
ER + EI R L V+ E++ +L Q + EL ++ NLE
Sbjct: 2083 ---EREEEEI----RGLHQSVR-ELQLTLAQKEQEILELRE-----TQQRNNLEA----- 2124
Query: 2204 KENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQ---- 2259
LP + P EE + + ++L +L+ +RL+A LR +++
Sbjct: 2125 ---LPHSHKTSPMEE-----------QSLKLDSLEPRLQRELERLQAALRQTEAREIEWR 2170
Query: 2260 --AEVLIKGKRQTEGTLHSLR 2278
A+ L QT+ ++ SL+
Sbjct: 2171 EKAQDLALSLAQTKASVSSLQ 2191
Score = 169 bits (427), Expect = 4e-41
Identities = 235/1114 (21%), Positives = 490/1114 (43%), Gaps = 139/1114 (12%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRAS-----KRQSEKEMEELHHNIDDLLQEKK 1371
E LE + + M+ +++++ EER S + ++EKE L ++ LLQ +K
Sbjct: 883 EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL---LETLLQTQK 939
Query: 1372 SLECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEK 1426
L ++L R Q + QK L T+L E++++ + H D + ++
Sbjct: 940 ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999
Query: 1427 TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
+LL+ + +L++ + + +S+L + + ++ + R + +ELER
Sbjct: 1000 SLLQDKMDLQKQ---VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS 1056
Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEE 1546
++L++ +Q+L LQ E I+Q+E L + + + + + LS + E L +E
Sbjct: 1057 LTLSLMEKEQRLLVLQ------EADSIRQQE-LSALRQDMQEAQGEQKELSAQMELLRQE 1109
Query: 1547 LQKLQKDI-----EMAERNEDHHL--QVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL 1599
+++ + D ++ E E H+ Q L+ S +AK A+L+ L+ + T Q E
Sbjct: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAA 1168
Query: 1600 DRQLGHKKEELHLLQGSMVQAKADLQEALRL---GETEVTEKCNHIREVKSLLEELS--- 1653
++Q G++ + Q + + LQ+AL E++ + V L + +
Sbjct: 1169 EQQPGNQAQA----QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224
Query: 1654 --FQKGELNVQISER--------------KTQLT--LIKQEIEKEEENLQVVLRQMSKHK 1695
F++G L +S KTQ T +++ +++K EE L + S+
Sbjct: 1225 SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
Query: 1696 TELKNI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKG 1752
TEL+++ L Q E + +G + + + EL +T +A L+ +L LQ++ Q +
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGER 1343
Query: 1753 EI-EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLA 1811
E+ + K+ L ++ E+RA S L ++ + + +++ +
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403
Query: 1812 AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE 1871
A +E +++ + + L+ N+ L Q L + + +L I +++Q + ++ A+ L
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSL 1463
Query: 1872 ELANVQDHLNLAKQDLLHTTKHQDVL----LSEQTRLQKDISEWANRFEDCQKEEETKQQ 1927
+L ++L ++ + K + VL ++ Q R QK ++ + + +K+ ET++
Sbjct: 1464 DLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK-LTVQREQIRELEKDRETQRN 1522
Query: 1928 QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE------KE 1981
L+ E+E+ + Q Q L+K+ + LE + L+E H++E KE
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVT----LECLALELEENHHKMECQQKLIKE 1578
Query: 1982 LTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE 2040
L Q+ L+ + L EER + LQ + LE + R+L ER+Q++ + +
Sbjct: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638
Query: 2041 LLALQKEADSMRAD--------------FSLLRNQFLTERKKAEKQVASLKEALK----- 2081
+ LQ++ + + D +L +Q + K E+ + +K +L+
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698
Query: 2082 --IQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQ 2139
QR +++ E K + + + ++L+ +D + + ++++Q ELK Q
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ----ELKDQ 1754
Query: 2140 MANQKD------------LERRQMEISDAMRTL-----KSEVKDE-IRTSLKNLNQFLPE 2181
+ Q L +R+ EI + L + E+K++ +++ L + L +
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814
Query: 2182 LPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKL 2241
+LEA+ + + +G+ E +KE +G E+ + + + + H + +E+
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADAL--QGALEQ----AHMTLKERHGELQDHKEQA 1868
Query: 2242 RHREDRLKAQLRHCMSKQAEV--LIKGKRQTEGTLHSLRRQVDALG---ELVTSTSADS- 2295
R E+ L + R + + + L R+ E L +L++Q E+ T DS
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Query: 2296 ----ASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
A Q +L +SQ ++QE+ A AR
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962
Score = 152 bits (383), Expect = 5e-36
Identities = 220/1014 (21%), Positives = 429/1014 (42%), Gaps = 92/1014 (9%)
Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKR 1387
++D+ Q L + ++ Q E+E + L + L E+ +L + +L V
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461
Query: 1388 QQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIECIEKTLLKRRSELREADRLL 1442
++++ + E L +LE+ + + + ++ + + + +++ EL A R
Sbjct: 462 SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521
Query: 1443 AEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQ 1502
+ L + K ++ + + +L + + E L + E L +A+Q + L
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 1503 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
+ L+ +++ + A D L+++ +L EE Q + +E AE+ +
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
L E+E +A + L++Q+ ++ A L L +EE +Q + +++
Sbjct: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
Query: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1682
QEA T + + + EE+ + + + K L + Q +E++ +
Sbjct: 702 Q-QEA-------ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 1683 NLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE----KL 1738
+L L+ +S K L++ L Q +N ++ K Q + ++ + + + + E KL
Sbjct: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKL 813
Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
EL+ + ++Q++ Q E++ + AL+ KE L+EK
Sbjct: 814 ELDTERSQAEQERDAAARQLAQAEQEGK---------TALEQQKAAHEKEVNQLREK--- 861
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
WEK+ + ++ LA A E+ + E+ LE + L ++ + E Q R++ + + Q Q
Sbjct: 862 WEKERSWHQQELAKALESLEREKMELE-MRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920
Query: 1859 LQEKREAVNSL------QEELANVQDHLNLAKQDL-LHTTKHQDVLLSEQTRL---QKDI 1908
L+ ++E V+ L Q+ELA+ L +QD+ + K Q+ QT+L Q+++
Sbjct: 921 LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL 980
Query: 1909 SEWANRFED----CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
E A + D Q+E + Q LQ ++E+ K +LV Q+ QRL E+E +E
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS-QRL-VEQEVQEKLR 1038
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTK 2024
ET ++ ++++KEL +K+ L L + E+R+ LQE + ++ LS +
Sbjct: 1039 ET------QEYNRIQKELEREKASLTLSL---MEKEQRLLVLQEAD---SIRQQELSALR 1086
Query: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKA--------------E 2070
+ + E + + E S ++ L++E ADF Q L E + + E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146
Query: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSC-IQKEMATIELVAQDNHERARRLMKELN-- 2127
+ A L+ L+ SQLE EQ+ N Q ++A++ Q EL+
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206
Query: 2128 -QMQYEYTELKKQMANQKDLERR--------QMEISDAMRTLKSEV--KDEIRTSLKNLN 2176
L+ + L +R ++ A+ L ++ + R L++
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQV 1266
Query: 2177 QFLPELPADLEAILERNENLEGELESLKENLPFTMNE-GPFEEKLNFSQVHIMDEHWRGE 2235
Q L E D EA + EL+ L+ L E +E K N + +M+ H
Sbjct: 1267 QKLEERLTDTEA---EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA 1323
Query: 2236 ALREKLRHRE-DRLKAQ-LRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGEL 2287
+L+ +LR E R++AQ R + E L + + R Q A G L
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGIL 1377
Score = 150 bits (380), Expect = 1e-35
Identities = 197/986 (19%), Positives = 415/986 (42%), Gaps = 103/986 (10%)
Query: 1325 VSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTV 1384
+S L + + L+S E +R + + + +I +L + +L+ EV +L
Sbjct: 539 LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598
Query: 1385 QKRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLA 1443
K + + + L +L ++E+ ++ + +E E+ + +L EA++
Sbjct: 599 VKLSALNEALALDKVGLNQQLLQLEEE---NQSVCSRMEAAEQARNALQVDLAEAEKRRE 655
Query: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 1503
+ + + + + A E + + L + + EE++++ E+ A QL L
Sbjct: 656 ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
Query: 1504 DAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE----- 1558
+AK E+ + + + + + AA + Q + + ++ L E+LQ L E+ E
Sbjct: 716 EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
Query: 1559 -RNEDHHLQVLK-ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
+ ++ ++V K + EV +Q E ++ +V + E LD + ++E
Sbjct: 776 AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE---LDTERSQAEQERDAAARQ 832
Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLE----ELSFQKGELNVQISERKTQLTL 1672
+ QA+ + + AL +K H +EV L E E S+ + EL + + +
Sbjct: 833 LAQAEQEGKTALE------QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886
Query: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELE---KT 1729
++ +++++ ++ + Q + +T+ ++ L +QLE + +RVS LE +T
Sbjct: 887 LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK---------ERVSLLETLLQT 937
Query: 1730 QVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE-SRALQSCVECLSKE 1788
Q + + +LE L+Q + QK + + +L+ +E +R E +R + + L +E
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
Query: 1789 KED-LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLS 1847
LQ+K D+ +K++ K L A +++ ++ +E V++ +E + NR +
Sbjct: 998 SSSLLQDKMDL-QKQVEDLKSQLVAQDDSQRL-------VEQEVQEKLRETQEYNRIQKE 1049
Query: 1848 LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1907
L + +++ L EK + + LQE + Q L+ +QD+
Sbjct: 1050 LEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM-------------------- 1089
Query: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETS 1967
++ Q E++ Q+++L+ E++E + + QE + E +L S
Sbjct: 1090 --------QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRAS 1141
Query: 1968 KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
+ + QL+ L +S+L+ LAAE++ + + SL L Q +
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLE-----ALAAEQQPGNQAQAQAQLASLYSALQQALGSV 1196
Query: 2028 SEREQQLV---EKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR 2084
E +L + + + L+ + + R+ F R LT A K + +
Sbjct: 1197 CESRPELSGGGDSAPSVWGLEPDQNGARSLFK--RGPLLTALSAEAVASALHKLHQDLWK 1254
Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQK 2144
+Q +++L + + +++ + E H + L ++L+Q Q E K Q
Sbjct: 1255 TQQTRDVLRDQVQK--LEERLTDTEAEKSQVHTELQDLQRQLSQNQ---EEKSKWEGKQN 1309
Query: 2145 DLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLK 2204
LE ME+ + M +L+S ++ R L+ + E + E + ENL ++E L+
Sbjct: 1310 SLESELMELHETMASLQSRLR---RAELQRM-----EAQGERELLQAAKENLTAQVEHLQ 1361
Query: 2205 ----ENLPFTMNEGPFEEKLNF--SQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
E G EE L S + + +E E R + + LK + +
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
Query: 2259 QAEVLIKGKRQTEGTLHSLRRQVDAL 2284
+L + + E + +LR Q+ L
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQEL 1447
Score = 135 bits (340), Expect = 5e-31
Identities = 226/1077 (20%), Positives = 459/1077 (42%), Gaps = 109/1077 (10%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
E NL+ + RLE+ Q +S +R +++ + L +++ L +
Sbjct: 92 EEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR-- 149
Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIE--------- 1422
+EL R + Q +++F G ++ L E+ +H ++ +
Sbjct: 150 -DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAE 208
Query: 1423 -----------CIEKTLLKRRSELREADRLLAEAESEL----SCTKEKTKNAVEKFTDAK 1467
C+ T+ + E + R+ ++L + T+E K A E+ +
Sbjct: 209 HVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI 268
Query: 1468 RSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
+ Q + + EL+ R E + L ++ +Q + K L + EIL E N
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE----TVEIL-ETNHTEL 323
Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIE--MAERNED------HHLQVLKESEVLLQAKR 1579
+ + ++EKL+ LQ++ KDI M E ++ H + +S + Q
Sbjct: 324 MEHEASLSRNAQEEKLS--LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDY 381
Query: 1580 AELEK----LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD---LQEALRLGE 1632
+ +K ++S +T ++Q + L +QL +E ++LLQ Q + + L++ L+
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
Query: 1633 TEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE---IEKEEENLQVVLR 1689
E +++ ++ LS ++ L E + QL +++QE + + LQ+
Sbjct: 442 GERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD 501
Query: 1690 QMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ-QISQ 1748
K E + L + E LQ + + + + SE +++ L E LE +L+ ++ +
Sbjct: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-SLSELITLREALESSHLEGELLR 560
Query: 1749 QQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKR 1808
Q++ E+ L R ++ I +++ L++ V L L + +
Sbjct: 561 QEQTEV---TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQ 617
Query: 1809 VLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNS 1868
L EE ++ S +E E LQ +L + + + +L + ++ QLQ+ EA
Sbjct: 618 QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Query: 1869 LQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET---K 1925
LQ +L ++Q+ ++ L + Q+ ++ +L ++ +E+E +
Sbjct: 678 LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVRE 737
Query: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQ 1985
+ L+V +E ++ L +Q Q L +E ES L + QQ E+T
Sbjct: 738 KAALEVRLQAVERDRQDLAEQ---LQGLSSAKELLESSL------FEAQQQNSVIEVT-- 786
Query: 1986 KSKLDQVLSKVLAAEERVRTLQEEERWCE---SLEKTLSQTKRQLSEREQQLVEKSGELL 2042
K +L+ + V A+E +Q E R + E++ ++ +R + R+ E+ G+
Sbjct: 787 KGQLEVQIQTVTQAKE---VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK-T 842
Query: 2043 ALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCI- 2101
AL+++ + + + LR ++ ER ++++A E+L+ ++ +LE L EQ+ E I
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 2102 --------QKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM----ANQKDLERR 2149
Q E A ++ + ER L++ L Q Q E + +Q+ + K + +
Sbjct: 903 AQREEERTQAESALCQMQLETEKERV-SLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
Query: 2150 QMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENL-- 2207
+ E + ++T E + E++ + + L L + ++L+ +L+ ++E LK L
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
Query: 2208 ---PFTMNEGPFEEKLNFSQVH--IMDEHWRGEA-LREKLRHREDRLKAQLRHCMSKQAE 2261
+ E +EKL +Q + I E R +A L L +E RL +Q E
Sbjct: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
Query: 2262 V--LIKGKRQTEGTLHSLRRQVDALGELVTSTSAD--SASSPSLSQLESSLTEDSQL 2314
+ L + ++ +G L Q++ L + V AD + + L +LE+S + QL
Sbjct: 1082 LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
Score = 124 bits (310), Expect = 1e-27
Identities = 226/961 (23%), Positives = 400/961 (41%), Gaps = 144/961 (14%)
Query: 232 TLPHYLQFTIFHLRSL-----ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
TL LQ + RS + LE R E E +L+E+ L R LE++
Sbjct: 54 TLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDEL--LVR-LEEEQQRC 110
Query: 287 EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRAC 346
E L T+ ++ D +NK+L+E+ E+L D + + L +K
Sbjct: 111 ESLAEVNTQLRLHMEKADVVNKALREDV-------EKLTVDWSRARDELMRK-------- 155
Query: 347 QKQYELEQELAFYKIDAKFE---------PLNYYPSEYAEIDKAPDESPYIGKSRYKRNM 397
+ Q+++EQE F+K K E + + + E+ A D K+ + R
Sbjct: 156 ESQWQMEQE--FFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLS 213
Query: 398 FATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELH 457
+ + + Q + EP+ R D L + ++ EK+ L +L
Sbjct: 214 GSLLTCCLRLTVGAQSR--EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLK 271
Query: 458 DE--IEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDL 515
+ +EKAE Q + +L + + + + K L ++++ E ++
Sbjct: 272 SQGDLEKAELQ-----DRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEH 326
Query: 516 ELQMEKQKQEIA-GKQKEIKDL-QIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK---- 569
E + + QE Q+ IKD+ Q+ ++ D+ AQ SG E L++ +
Sbjct: 327 EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI--------AQGSGHENSLELDSSIFSQ 378
Query: 570 -QYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN------EALKKDLEGVISGLQ 622
YQ + L + S + + + ++DL +QL Q A N + +++ + + LQ
Sbjct: 379 FDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ 438
Query: 623 EYLG---TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAE 679
+ G T+ GQ Q E L E+E LLQ+ E+ R QLE++ +A +R+ E
Sbjct: 439 KLTGERDTLAGQTVDLQGEVDSLSKERE-LLQKAR--EELRQQLEVLEQEAWRLRRVNVE 495
Query: 680 L----ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
L +SA ++ E QQ + L+ E E + L EA Q + E +T L
Sbjct: 496 LQLQGDSAQGQKEE-----QQEELHLAVRERERLQEM-LMGLEAKQSESLSELITLREAL 549
Query: 736 EQSALQAELEKERQA-LKNALGKAQ--FSEEKEQENS-------------ELHAKLKHLQ 779
E S L+ EL ++ Q + AL +A+ +E EN+ +L A + L
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609
Query: 780 DDNNLLKQQLKDFQNHLNHVVDGLVRPEEV--AARVDELR-RKLKLGTGEMNIHSPSDV- 835
D L QQL + V + E+ A +VD K + E N H + +
Sbjct: 610 LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQ 669
Query: 836 --------LGKSLADLQKQFSEI---LARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
L L D+Q++ EI L+ S+ +++ A + +L +E Q+E LA +
Sbjct: 670 KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729
Query: 885 EFRQACER---ALEARMNFDKRQHEARIQQ----------MENEIHYLQENLKSMEEIQG 931
E ++A R ALE R+ +R + +Q +E+ + Q+ +E +G
Sbjct: 730 E-KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 932 LTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 991
++Q+Q + KE I ++R L+ + E ++++++ + A A A
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE-----------RDAAARQLAQAE 837
Query: 992 AELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIE--LLQNL 1049
E A +Q K+ H ++NQ R + +E ++ A+A L R + E+E L +
Sbjct: 838 QEGKTALEQQKAAH--EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895
Query: 1050 LRQKGEQFRLEMEKTGVGTGANSQVLEIEK----LNETMERQRTEIARLQNVLDLTGSDN 1105
+ Q + E E+T + LE EK L ET+ + + E+A L+ D
Sbjct: 896 TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955
Query: 1106 K 1106
K
Sbjct: 956 K 956
Score = 116 bits (290), Expect = 3e-25
Identities = 220/1048 (20%), Positives = 436/1048 (41%), Gaps = 147/1048 (14%)
Query: 88 IKKLTKQDNL--ALIKSLNLSLSKDGGK---KFKYIENLEKCVKLEVLNLSYNLIGKIEK 142
I++L KQ + A ++ L+L L K + + + I+ LEKC + +E
Sbjct: 1444 IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV------------LEH 1491
Query: 143 LDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKG 202
L ++ RE L+ + +I +E Q+ N +EH + L KK + +
Sbjct: 1492 LPMAVQEREQKLTVQR-EQIRELEKDRETQR-----NVLEHQLLELEKKDQMIE------ 1539
Query: 203 NKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQE 262
++ +QD+ K + ++L L EN H ++ + ++ LEGQ T ++
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENH-----HKMEC---QQKLIKELEGQRET---QRV 1588
Query: 263 AFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
A +L+ ER ++L+ + + +L+S T E++ +D+ KS +E+ ++ E
Sbjct: 1589 ALTHLTLDLEER-SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE 1647
Query: 323 ELKSDLNTKN-ELLKQK----TIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE 377
L DL ++ EL+ QK +E R Q + LE++L K+ +
Sbjct: 1648 HLTQDLERRDQELMLQKERIQVLEDQRTRQTKI-LEEDLEQIKLSLRERGRELTTQRQLM 1706
Query: 378 IDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDT 437
++A + G S+ +R I+ + K++E ++ ++ L+ L+
Sbjct: 1707 QERAEEGK---GPSKAQRGSLEHMKLILRDKE----KEVECQQEHIHELQELKDQ--LEQ 1757
Query: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
QL+ +K+ LS+ EI +QQ+ A E+ + E+++Q ++ EA +
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ-SQLDEA-----QRA 1811
Query: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 557
L+ R Q + L+QE + Q E+ K++ Q ++ + + + H K Q
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH---KEQA 1868
Query: 558 SGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 617
E++L + ++ Q LE L ++ + ++ + + L++Q E +A + ++E
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE------QAQEHEVE-- 1920
Query: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
++ QAQ ++ E E L E + R Q E AE +++ L
Sbjct: 1921 -------TRALQDSWLQAQAVLKERDQELEALR---AESQSSRHQEEAARARAEALQEAL 1970
Query: 678 AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
+ +ALQ + + + L A A L+A L+ A + QL+E L R+ + E
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL----RIQEGEI 2026
Query: 738 SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN 797
+++ Q L+ AL + +QE +L K + N+++++ QN
Sbjct: 2027 QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEK----QNL-- 2080
Query: 798 HVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE 857
G R EE + + R+L+L +LA +++ E+ +
Sbjct: 2081 ----GQEREEEEIRGLHQSVRELQL----------------TLAQKEQEILELRETQQRN 2120
Query: 858 RDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEAR--IQQMENE 915
EA K M Q KL + + ++ ER A + R+ E R Q +
Sbjct: 2121 NLEALPHSHK-TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
Query: 916 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975
+ + ++ S++E+ + E D E++R+ +L EL ++ L+KE
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL-ELTRR-------------ALEKE 2225
Query: 976 LKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035
A +T++ + E + ++ + E+ Q E + A+ D
Sbjct: 2226 RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID 2285
Query: 1036 LTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQ 1095
+R + L++ L Q E+ R ++++ + A + LEI K + Q+
Sbjct: 2286 RSRLQRHNVQLRSTLEQV-ERERRKLKREAM-RAAQAGSLEISKATASSPTQQ------- 2336
Query: 1096 NVLDLTGSDNKGGFENVLEEIAELRREV 1123
D +G + + +AEL++EV
Sbjct: 2337 --------DGRGQKNSDAKCVAELQKEV 2356
Score = 111 bits (278), Expect = 7e-24
Identities = 181/776 (23%), Positives = 333/776 (42%), Gaps = 123/776 (15%)
Query: 1336 KSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFID 1395
K+++ M+ R EKE+E +I +L + K LE +++ LHR V
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV----------- 1766
Query: 1396 GNVESLMT--ELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTK 1453
G L++ E EI + ++ ++ E E++L +S+L EA R LA+ + EL +
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL---QSQLDEAQRALAQRDQELEALQ 1823
Query: 1454 EKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKD-LEQHK 1512
++ + Q + E ++ +A L +A L+ + +D EQ +
Sbjct: 1824 QEQQ--------------QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR 1869
Query: 1513 IKQEEILKEINKIVAAKD--SDFQCLSKKKEKLTEELQKLQKDIEMAERNE-------DH 1563
+EE+ E ++ A ++ D + S+++EK LQ Q+ E A+ +E D
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ--QQCAEQAQEHEVETRALQDS 1927
Query: 1564 HLQ---VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH-----KKEELHLLQG 1615
LQ VLKE + L+A RAE + + Q + + L LG + +E HLL+
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ 1987
Query: 1616 S-----------MVQAKAD--------LQEALRLGETEVTEK-CNHIREVKSLLEELSFQ 1655
+ +QA D L+EALR+ E E+ ++ + +V+ L + L+ +
Sbjct: 1988 AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR 2047
Query: 1656 KGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
EL Q + + QL L K ++ +EN+ + + + + E + + L ELQ
Sbjct: 2048 DEELRHQ--QEREQL-LEKSLAQRVQENMIQEKQNLGQEREEEE--IRGLHQSVRELQLT 2102
Query: 1716 KLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAES 1775
Q +Q + EL +TQ + NL+ + K ++Q L+ D E R+ E
Sbjct: 2103 LAQKEQEILELRETQ--------QRNNLEALPHSHKTS-PMEEQSLKLDSLE-PRLQREL 2152
Query: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQ 1835
LQ+ + + + +EK LAQTK +++ +E + Q+++ + + ++LQ
Sbjct: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ 2212
Query: 1836 QELDQLNR--DKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1893
EL+ R +K LH+ + +L + E L E++ V+
Sbjct: 2213 DELELTRRALEKERLHSPGATSTAELGSRGEQGVQL-GEVSGVE---------------- 2255
Query: 1894 QDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRL 1953
+E + + W R E Q+ + LQ + + L Q E ++L
Sbjct: 2256 -----AEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
Query: 1954 QKE--RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER 2011
++E R ++ LE SK T Q + + +K L K + + TL+ +++
Sbjct: 2311 KREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQK 2370
Query: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK-------EADSMRADFSLLRN 2060
+ +QT R+L+ L S LLA+ + EA++ R D SL ++
Sbjct: 2371 --QDYITRSAQTSRELAGLHHSL---SHSLLAVAQAPEATVLEAETRRLDESLTQS 2421
Score = 106 bits (265), Expect = 2e-22
Identities = 198/950 (20%), Positives = 388/950 (40%), Gaps = 145/950 (15%)
Query: 269 LEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDL 328
+E L R+ +++ + +++ T+ + ++ D + + E L+ S + D
Sbjct: 324 MEHEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHENSLELDSSIFSQFDY 381
Query: 329 NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
++ L LTR Q +L Q+LA + E +N ++ + ++
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ-----EAVNLLQQQHDQWEEE------- 429
Query: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKI-- 446
GK+ +R T + Q V ++ E D + + + L QLE E++
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQG-EVDSLSKERELLQKAREELRQQLEVLEQEAWR 488
Query: 447 ------------SAAQTRLSELHDEIEKAEQQILRATE-----EFKQLEEAIQLKKISEA 489
+AQ + E +E+ A ++ R E E KQ E +L + EA
Sbjct: 489 LRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA 548
Query: 490 GKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPK 549
L L G L LRQE ++ + + +Q IA L+ + L + K
Sbjct: 549 ---LESSHLEGEL-----LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 550 HSHMKA----QKSGKEQQLDIMNKQYQQLESRLDEI----------LSRIAKETEEIKD- 594
S + K G QQL + ++ Q + SR++ L+ K E + +
Sbjct: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
Query: 595 ---LEEQLTEGQIAANE--ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE---- 645
LE QL + + A E A +D++ +Q+ L + Q A + +L E
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 646 KETLLQRLTEVE---QERDQLEIVAMDAENMRKELAE-----------LESALQEQHEVN 691
+E L + + E E +E+ LE+ E R++LAE LES+L E + N
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
Query: 692 ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL 751
+ ++ T+G L + + E LK EL+ + E+ A +L + Q
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG 840
Query: 752 KNALGKAQFSEEK---------EQENS----ELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
K AL + + + EK E+E S EL L+ L+ + L+ +LK+ Q +
Sbjct: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM-- 898
Query: 799 VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSD--VLGKSLADLQKQFSEILARSKW 856
E + A+ +E R + + +M + + + L ++L QK+ ++ + +
Sbjct: 899 --------EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER 950
Query: 857 ERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENE- 915
R + +V++ K QE + Q +L Q E ++A RQH + ++ E
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA------------RQHRDDLAALQEES 998
Query: 916 IHYLQENLKSMEEIQGLTDLQLQEADEEK---ERILAQLRELEK----KKKLEDAKSQEQ 968
LQ+ + ++++ L + + D ++ + + +LRE ++ +K+LE K+
Sbjct: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
Query: 969 VFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE----RAEELQEAER 1024
+ ++KE + L + +D + EL+ + ++ G +++ + R E ++
Sbjct: 1059 LSLMEKEQRLL--VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116
Query: 1025 FSRKAAQAARDLTRAE-AEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
F + AQ +L + E +L +L Q+ + +L++ T + + L E+
Sbjct: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR--STESQLEALAAEQQPGN 1174
Query: 1084 MERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
+ + ++A L + L + L + E R E+S D S+
Sbjct: 1175 QAQAQAQLASLYSAL-----------QQALGSVCESRPELSGGGDSAPSV 1213
Score = 104 bits (259), Expect = 1e-21
Identities = 172/925 (18%), Positives = 376/925 (40%), Gaps = 154/925 (16%)
Query: 245 RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQD 304
+ +E L+ Q V D Q +E+++++K+ ET+E Q LE K
Sbjct: 1010 KQVEDLKSQLVAQDDSQRL-----------VEQEVQEKLRETQEYNRIQKE-LEREKASL 1057
Query: 305 KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
L+ KE+ +L Q + ++ + L+Q ++ A +Q EL ++ + + K
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQ---ELSALRQ---DMQEAQGEQKELSAQMELLRQEVK 1111
Query: 365 FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
+ ++ E +++ E+ +I + + + +++A E+ A +Q++ + QL
Sbjct: 1112 EKEADFLAQEAQLLEEL--EASHITEQQLRASLWAQEA----KAAQLQLRLRSTESQLEA 1165
Query: 425 DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ-- 482
E + + AQ +L+ L+ +++A + + E ++
Sbjct: 1166 ------------LAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
Query: 483 ---------LKKISEAGKDLLYKQLSGRLQLVNKLRQEALD-------LELQMEKQKQEI 526
+ + + G L ++KL Q+ L Q++K ++ +
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 527 AGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIA 586
+ E + + L + ++ K++ GK+ L+ + +L + + SR+
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE---SELMELHETMASLQSRLR 1330
Query: 587 KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
+ +L+ +G+ +A K++L + LQ + + QA+ A LR +
Sbjct: 1331 RA-----ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTAR 1385
Query: 647 ETLLQRLTEVEQER-------DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQG 699
L + EVE ER +Q E+ + +++ LA L L E+ E ++ +G
Sbjct: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE---EVETLRG 1442
Query: 700 DLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQ 759
+ ELE + ++ A L +L+K + L+Q +Q ELEK R L++ Q
Sbjct: 1443 QIQ----ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ-ELEKCRSVLEHLPMAVQ 1497
Query: 760 FSEEKEQENSELHAKLKHLQDD----NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDE 815
E+EQ+ + +++ L+ D N+L+ QL + + D ++ E +V +
Sbjct: 1498 ---EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK-----DQMI--ESQRGQVQD 1547
Query: 816 LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQ 875
L+++L E LA E ++KL +E+ Q
Sbjct: 1548 LKKQLVT-------------------------LECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 876 QEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDL 935
+E +R + D + +Q ++IH L+ + +
Sbjct: 1583 RE------------TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR------- 1623
Query: 936 QLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELT 995
+LQE D+E + Q+ EL+++K+ + + D+EL K+ + + T +
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKE----HLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679
Query: 996 IAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE-AEIELLQNLLRQKG 1054
I ++ L+ + ++ +ER EL + ++ A+ + ++A+ +E ++ +LR K
Sbjct: 1680 ILEEDLEQIKLSL----RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735
Query: 1055 EQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLE 1114
++ + E + E+++L + +E+Q + R L S + + +
Sbjct: 1736 KEVECQQE----------HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785
Query: 1115 EIAELRREVSYQNDYISSMADPFKR 1139
++ E R + + + S D +R
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQR 1810
Score = 49.7 bits (117), Expect = 3e-05
Identities = 71/340 (20%), Positives = 141/340 (41%), Gaps = 56/340 (16%)
Query: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQ 1985
++Q+ LQ ++ EN+ ++ Q Q+ + + KL+ + + +LEK L
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80
Query: 1986 KSKLDQVLSKVLA--AEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLA 2043
+ Q V +E + L+EE++ CESL + T+ +L + +V K A
Sbjct: 81 GGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEV--NTQLRLHMEKADVVNK-----A 133
Query: 2044 LQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQL---------------- 2087
L+++ + + D+S R++ + + + + + K LK + +L
Sbjct: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
Query: 2088 -----EKNLLEQKQENSCIQKEMAT----IELVAQDNHERARRLMKELNQMQYEYTELKK 2138
+++L+E K E+ + + T + + AQ M E +L
Sbjct: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-----GREPAQLLL 248
Query: 2139 QMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG 2198
+A ++LE+ E S + LKS+ E L + EL A L ++NE+ E
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLE----KAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 2199 ELESLKENLPF-------------TMNEGPFEEKLNFSQV 2225
+++L+E + +++ EEKL+ QV
Sbjct: 305 MIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV 344
Score = 47.0 bits (110), Expect = 2e-04
Identities = 55/268 (20%), Positives = 117/268 (43%), Gaps = 13/268 (4%)
Query: 1963 KLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEER----VRTLQEE----ERWCE 2014
K ++ ++ L+EQ L++++ + ++ + L A++R VR LQ + WC+
Sbjct: 12 KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ 71
Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD-FSLLRNQFLTERKKAEKQV 2073
LEK L T + +R + + E + + L ++ E + R + + + Q +KA+
Sbjct: 72 ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
+L+E ++ + E ++ S Q E + + H R L +E+ + +
Sbjct: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
Query: 2134 TELKKQM-ANQKDLERRQMEISDAMRT--LKSEVKDEIRTSLKNLNQFLPELPADLEAIL 2190
E+K + +L+ + +S ++ T L+ V + R + PA L +L
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP-NGSGRMDGREPAQLLLLL 250
Query: 2191 ERNENLEGELESLKENLPFTMNEGPFEE 2218
+ + LE E + L ++G E+
Sbjct: 251 AKTQELEKEAHERSQELIQLKSQGDLEK 278
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 180 bits (457), Expect = 1e-44
Identities = 234/1067 (21%), Positives = 463/1067 (43%), Gaps = 143/1067 (13%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD----------- 1365
+H L E + L + +Q E MRA ++E+EE+ H+++
Sbjct: 881 KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI 940
Query: 1366 LLQEKKSLECEVEELHRTV-------QKRQQQKDFIDGNV-----ESLMTELEIEKSLKH 1413
L EKK ++ +++L + QK Q +K + + E L+ E + K +K
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
Query: 1414 HEDIVDEI-ECI-----EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAK 1467
+ + D I EC E+ K +++R ++ E +EKT+ +EK AK
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK---AK 1057
Query: 1468 RSLLQTESDAE----ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEIN 1523
R L +D + EL+ + E + L K +++L+ A D HK ++++E+
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 1524 KIVAAKDSDFQC-------LSKKKEKLTEELQKLQKDIE--MAERNEDHHLQVLKESEV- 1573
+A DF+ K+K L+EEL+ L+ ++E + L+ +E EV
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 1574 -LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
L +A E + ++Q+ +Q A +L + E+ + ++ + K L E
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL-------E 1230
Query: 1633 TEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVL-RQM 1691
T+ E ++ ++ + E ++ +L+ Q+ E +++ E + L+V L +
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS--------EGDRLRVELAEKA 1282
Query: 1692 SKHKTELKNILDMLQLENHELQGLKLQHD--QRVSELEKTQVAVLEE---KLELENLQQI 1746
SK + EL N+ + LE E +G+K D S+L+ TQ + EE KL L + +
Sbjct: 1283 SKLQNELDNVSTL--LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED---LQEKCDIWEKKL 1803
+++K ++ Q++ E ++ +E+ ALQS + K+ +D E + +KKL
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVL---ALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
+ L+ E + LEK + +LQQELD L D L +R
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTK---NRLQQELDDLTVD--------------LDHQR 1440
Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
+ ++L+++ K D LL+E+ + +E +R E +E+E
Sbjct: 1441 QVASNLEKK------------------QKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Query: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELT 1983
TK L E E K + F+R K+ ++ L +SK + + H+LEK
Sbjct: 1483 TKALSLARALEEALEAKEE-------FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 1984 DQKSKLDQVLSKVLAAEERVRTLQEEERWCE-SLEKTLSQTKRQLSEREQQLVEKSGELL 2042
+ +++++ +++ E+ ++ ++ + E +++ +Q +R L R++Q EK L+
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 2043 ALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK---EALKIQRSQLEKNLLEQKQENS 2099
+E ++ D R + +KK E + L+ EA R ++ K L + + +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 2100 CIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT 2159
Q+E+ + +++ K+L ++ E +L++++A+ + R + D
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD---- 1711
Query: 2160 LKSEVKDEIRTSLKNLNQFLPE---LPADLEAILERNENLEGELESLKENLPFTMNEGPF 2216
E+ DEI S + L E L A + + E E + +E L + T +
Sbjct: 1712 ---ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ--- 1765
Query: 2217 EEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHS 2276
+ LN + + R++L + LKA+L ++ E +K K + T+ +
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL-----QELEGAVKSK--FKATISA 1818
Query: 2277 LRRQVDALGELVTSTSADSASSPSL-SQLESSLTEDSQLGQNQEKNA 2322
L ++ L E + + + A++ L + E L E +++ ++A
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA 1865
Score = 145 bits (365), Expect = 6e-34
Identities = 225/969 (23%), Positives = 424/969 (43%), Gaps = 144/969 (14%)
Query: 1453 KEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS---LQADAKDLE 1509
+E+ + E+ K + E + EE+ER+ Q+ +QL++ L A+A+++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 1510 QH----KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAER------ 1559
K + EEIL ++ V ++ Q L +K+K+ +Q L++ ++ E
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 1560 ----NEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
+ ++ ++E +LL+ + ++ K K + + E + + K + L ++
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQ 1675
+DL+E RL + E T +E++ +L + +L QI+E + Q+ +K
Sbjct: 1031 KQEVMISDLEE--RLKKEEKTR-----QELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 1676 EIEKEEENLQVVLRQ---MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
++ K+EE LQ L + + HK ++ LQ + ELQ ++ EK +
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 1733 VLEE----KLELEN-LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
+ EE K ELE+ L + QQ+ + ++++ E K E +Q + +
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203
Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQ-------ELDQ 1840
E+L E +L Q KR A E+N + +++ ++L V+ LQQ + +
Sbjct: 1204 ALEELSE-------QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKH------- 1893
L+ LH +S + E E + LQ EL NV L A++ + K
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 1894 -QDV--LLSEQTRLQKDIS-------EWANRFEDCQKEEETKQQQLQ----VLQNE---- 1935
QD LL E+TR + ++S E N ++ Q+EEE ++ L+ LQ++
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 1936 -------------IEENKLKLVQQ-EMMFQRLQKERESEESKLETSKVTLKEQ------- 1974
+EE K KL++ E + QRL+ E+ KLE +K L+++
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE-EKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 1975 ---QHQLEKELTDQKSKLDQVLSKVLA-----AEERVRTLQEEERWCESLEKTLSQTKRQ 2026
Q Q+ L ++ K DQ+L++ + AEER R + E R E+ +L++ +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA-EAEAREKETKALSLARALEE 1494
Query: 2027 LSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQ 2086
E +++ ++ +L A ++ S + D ++ ++ E+QV E ++ Q +
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV----EEMRTQLEE 1550
Query: 2087 LEKNLLEQKQENSCIQKEMATIELVAQ----------DNHERARRLMKELNQMQYEYTEL 2136
LE L Q E++ ++ E+ + AQ N E+ R L+K++ +++ E +
Sbjct: 1551 LEDEL--QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 2137 KKQMA-----------NQKDLE-------RRQMEISDAMRTLKSEVKDEIRTSLKNLNQF 2178
+KQ A + KDLE + + E+ +R L++++KD R L+
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR-ELEEARAS 1667
Query: 2179 LPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGE-AL 2237
E+ A + ++ ++LE E+ L+E L + E+ + G+ AL
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDAL-GELVTSTSADSA 2296
++ R E R+ +Q+ + + R + TL QVD L EL SA
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL-----QVDTLNAELAAERSAAQK 1782
Query: 2297 SSPSLSQLE 2305
S + QLE
Sbjct: 1783 SDNARQQLE 1791
Score = 136 bits (342), Expect = 3e-31
Identities = 192/874 (21%), Positives = 382/874 (43%), Gaps = 126/874 (14%)
Query: 1321 LENEVSRLEDIM------QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE 1374
LE + LED + Q L++K+ +E + K+ E+E + I D+ Q +
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQE--VAELKKALEEETKNHEAQIQDMRQRHATA- 1204
Query: 1375 CEVEELHRTVQKRQQQKDFIDGNVESLMTE-LEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
+EEL +++ ++ K ++ N + L T+ E+ +K + + E E K L +
Sbjct: 1205 --LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 1434 ELR----EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
EL E DRL E + S + + N +A++ ++ DA LE + Q+T
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
L + +Q +L + + LE+ K +E +E + A K+ + Q L+ + + L + +K
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE--ARKNLEKQVLALQSQ-LADTKKK 1379
Query: 1550 LQKDIEMAERNEDHHLQVLKESEVL---LQAKRAELEKLKSQVTSQQQEMAVLDRQLGHK 1606
+ D+ E E+ ++LK++E L L+ K +KL+ QQE+ L L H+
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 1607 KEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 1666
++ L+ Q K D + E KS+ + ++ + E+
Sbjct: 1440 RQVASNLEKK--QKKFD----------------QLLAEEKSISARYAEERDRAEAEAREK 1481
Query: 1667 KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQGLKLQHDQRV 1723
+T+ + + +E+ E + RQ + + ++++++ D + HEL+ K +Q+V
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Query: 1724 SELEKTQVAVLEE--------KLELE-NLQQISQQQKGEI-------EWQKQLLERDKRE 1767
E+ +TQ+ LE+ KL LE N+Q + Q + ++ E +K+LL + RE
Sbjct: 1542 EEM-RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 1768 IERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKL 1827
+E + R Q + SK+K ++ K AQ + A +E K L KL
Sbjct: 1601 LEAELEDERK-QRALAVASKKKMEIDLK-----DLEAQIEAANKARDEVIKQ----LRKL 1650
Query: 1828 ELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD- 1886
+ ++ Q+EL++ + + +++L+ + LQEELA+ + A+Q+
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 1887 ------LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENK 1940
+ ++ + LL E+ RL+ I++ ++E E +Q +++L + +
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQ-------LEEELEEEQSNMELLNDRFRKTT 1763
Query: 1941 LKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAE 2000
L++ L E +E S + S + QLE++ + K+KL ++ V +
Sbjct: 1764 LQV-------DTLNAELAAERSAAQKSD----NARQQLERQNKELKAKLQELEGAVKS-- 1810
Query: 2001 ERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRN 2060
+ T+S + ++ + E+QL +++ E A K +
Sbjct: 1811 --------------KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 2061 QFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERAR 2120
Q ER+ A++ +++A + QL++ L E ++E A + R
Sbjct: 1857 QVEDERRHADQYKEQMEKA-NARMKQLKRQLEEAEEE--------------ATRANASRR 1901
Query: 2121 RLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
+L +EL+ L ++++ K+ RR IS
Sbjct: 1902 KLQRELDDATEANEGLSREVSTLKNRLRRGGPIS 1935
Score = 134 bits (336), Expect = 1e-30
Identities = 171/737 (23%), Positives = 317/737 (43%), Gaps = 99/737 (13%)
Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKS 1647
QVT Q++E+ D +L KE+ ++G + E+ K + E K+
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGEL---------------EEMERKHQQLLEEKN 890
Query: 1648 LLEELSFQKGELNVQISERKTQLTLIKQE-----------IEKEEENLQVVLRQMSKHKT 1696
+L E + EL + E + +L KQE +E+EEE Q++ + K +
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVL-----------EEKLELENLQQ 1745
++++ + L E Q L+L+ ++++K + +L E+KL + + +
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 1746 ISQQQKGEIEWQKQLLE-RDKREI------ERMTAESRA---LQSCVECLSKEKEDLQEK 1795
S Q E E K L + R+K+E+ ER+ E + L+ L E DLQ++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 1796 CDIWEKKLAQTKRVLAAAEE--NSKMEQSNLEKLELN-----VRKLQQELDQLNRDKLSL 1848
+ ++ + K LA EE + + + E L N VR+LQ ++ +L D S
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 1849 HNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV-----LLSEQTR 1903
+ ++Q ++ E + +L+ EL + D A Q L T + Q+V L E+T+
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLD--TTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 1904 -LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENK-------LKLVQQEMMFQRLQK 1955
+ I + R +E + +Q + + +E+NK +L + + Q+++
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 1956 ERESEESKLETSKVTLK---EQQHQLEKELTDQKSKLDQVLSKV-LAAEERVRTLQEEER 2011
E E + KL+ L + +L EL ++ SKL L V EE + + +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEK 2071
SLE L T+ L E +Q + S + L++E +S++ + + RK EK
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ----QEEEEEARKNLEK 1364
Query: 2072 QVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA---RRLMKELNQ 2128
QV +L+ L + +++ +L + +K + E ++Q E+A +L K N+
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 2129 MQYEYTELKKQMANQK----DLERRQMEISDAMRTLKS------EVKDEIRTSLKNLNQF 2178
+Q E +L + +Q+ +LE++Q + + KS E +D +
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK 1484
Query: 2179 LPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRG---- 2234
L LE LE E E + + L+ ++ M+ K VH +++ R
Sbjct: 1485 ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK----NVHELEKSKRALEQQ 1540
Query: 2235 -EALREKLRHREDRLKA 2250
E +R +L ED L+A
Sbjct: 1541 VEEMRTQLEELEDELQA 1557
Score = 127 bits (320), Expect = 1e-28
Identities = 199/931 (21%), Positives = 394/931 (42%), Gaps = 116/931 (12%)
Query: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
+ L+ + VT + + + E L ++ + +++K + + + ++ EE + L
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 308 KSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367
K ++ ++ E LK + T+ EL K K + + +L+ ++A ++ A+ +
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKR----KLDGETTDLQDQIA--ELQAQIDE 1080
Query: 368 LNYYPSEYAE-----IDKAPDESPYIGKS-RYKRNMFATESYIIDSAQAVQIKKMEPDEQ 421
L ++ E + + DE+ + + + R + A + + + ++ + + + ++Q
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 422 LRNDHMNLRGHTPLDTQLED--------------KEKKISAAQTRLSEL---HD-EIEKA 463
R+ L L T+LED +E++++ + L E H+ +I+
Sbjct: 1141 KRDLSEELEA---LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 464 EQQILRATEEF-KQLEEAIQLKKISEAGKDLLY---KQLSGRLQLVNKLRQEALDLELQM 519
Q+ A EE +QLE+A + K E K L K+L+ ++++ +++ E+ ++
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 520 EKQKQEIAGKQKEIKDLQIAIDSLDSK-DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL 578
+ Q QE+ K E L++ + SK + ++ E++ K LES+L
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 579 DEILSRIAKETEE-------IKDLEEQ---LTEGQIAANEALKKDLEGVISGLQEYLGTI 628
+ + +ET + I+ LEE+ L E Q EA +K+LE + LQ L
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA-RKNLEKQVLALQSQLADT 1376
Query: 629 K-------GQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
K G + +KL + E L QRL E D+LE +++EL +L
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE---KTKNRLQQELDDLT 1433
Query: 682 SALQEQHEVNASLQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQ 737
L Q +V ++L++ Q L A E + AR RD + +E+ K L + +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 738 SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN 797
AL+A+ E ERQ + K+ +H L+ L+QQ+++ + L
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH----ELEKSKRALEQQVEEMRTQLE 1549
Query: 798 HVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE 857
+ D L E+ R+ E+N+ + + L +Q E K
Sbjct: 1550 ELEDELQATEDAKLRL------------EVNMQAMKAQFERDLQTRDEQNEE-----KKR 1592
Query: 858 RDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIH 917
QVRE + + E +Q LA ++ + + LEA++ + + I+Q+
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK--- 1649
Query: 918 YLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELK 977
LQ +K + +L+EA ++ I AQ +E EKK K L+ E+
Sbjct: 1650 -LQAQMKDYQR-------ELEEARASRDEIFAQSKESEKKLK-----------SLEAEIL 1690
Query: 978 KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
+L++ +A+S++ A+ + L + ++ L E R + AQ +L
Sbjct: 1691 QLQEELASSERARRH----AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE 1746
Query: 1038 RAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGA-NSQVLEIEKLNETMERQRTEI-ARLQ 1095
++ +ELL + R+ L+++ A S + + + +ERQ E+ A+LQ
Sbjct: 1747 EEQSNMELLNDRFRKT----TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 1096 NVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
+ S K + +I +L ++ +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833
Score = 123 bits (309), Expect = 2e-27
Identities = 209/984 (21%), Positives = 427/984 (43%), Gaps = 132/984 (13%)
Query: 209 QDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFS 268
Q +S LK LQ + L L H+ + +F + +P+ RQE +
Sbjct: 811 QQLSALKVLQRNCAAYL------KLRHWQWWRVF-------TKVKPLLQVTRQEEELQAK 857
Query: 269 LEEVERLERDLEKKMIETEELKSKQTRFLEE---IKNQDKLNKSLKEEA-------MLQK 318
EE+ +++ K E EE++ K + LEE + Q + L EA +K
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 319 QSCEELKSDLNTKNELLKQKTIELTRACQKQ----YELEQELAFYKIDAKFEPLNYYPSE 374
Q EE+ DL ++ E +++ L +K +LE++L + + L +E
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 375 YAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH-- 432
A+I K +E + K F E +++ A ++ +E+ + +R
Sbjct: 978 -AKIKKMEEEILLLEDQNSK---FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 433 ---TPLDTQLEDKEK---KISAAQTRL----SELHDEIEKAEQQILRATEEFKQLEEAIQ 482
+ L+ +L+ +EK ++ A+ +L ++L D+I + + QI + + EE +Q
Sbjct: 1034 VMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQ 1093
Query: 483 LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
++ + L+K + L++V +L+ + +L+ E +K +K+ +DL +++
Sbjct: 1094 -GALARGDDETLHK--NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 543 L-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE 597
L D+ D + + + +++ ++ ++ ++ +I + +++L E
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210
Query: 598 QLTEG-QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEV 656
QL + + AN L+K+ +G+ + +E +K Q + E R + + +Q L
Sbjct: 1211 QLEQAKRFKAN--LEKNKQGLETDNKELACEVK-VLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 657 EQERDQLEI-VAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLR 715
E D+L + +A A ++ EL + + L+E + + D ++ E++L+ L
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK---DAASLESQLQDTQELL 1324
Query: 716 DAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKL 775
E Q K L R + E+++LQ + E+E +A KN ++ S+L
Sbjct: 1325 QEETRQ-KLNLSSRIRQLEEEKNSLQEQQEEEEEARKN------LEKQVLALQSQLADTK 1377
Query: 776 KHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEVAARVDEL---RRKLKLGTGEMNIH- 830
K + DD + + L++ + L + L R EE A D+L + +L+ ++ +
Sbjct: 1378 KKVDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 831 SPSDVLGKSLADLQKQFSEILARSK---------WERDEAQVRERKLQ--------EEMA 873
+ +L QK+F ++LA K +R EA+ RE++ + EE
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 874 LQQEKLATGQEEFRQACERALEARMNFDKRQH---------EARIQQMENEIHYLQENLK 924
+E+ ++ R E + ++ + K H E ++++M ++ L++ L+
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Query: 925 SMEEIQGLTDLQLQ--------------EADEEKERIL-AQLRELEKKKKLEDAKSQEQV 969
+ E+ + ++ +Q E +EEK+R+L Q+RELE +LED + Q +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE--AELEDERKQRAL 1614
Query: 970 FGLDK-----ELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
K +LK L+ + ++K + QL+ L + +E E +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVI----KQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 1025 FSRKAAQAARDLTRAEAEIELLQNLL------RQKGEQFRLEM--EKTGVGTGANSQVLE 1076
++ ++ + L EAEI LQ L R+ EQ R E+ E T +G ++ + E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 1077 IEKLNETMERQRTEIARLQNVLDL 1100
+L + + E+ Q+ ++L
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMEL 1754
Score = 122 bits (306), Expect = 4e-27
Identities = 169/767 (22%), Positives = 341/767 (44%), Gaps = 94/767 (12%)
Query: 1635 VTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL---QVVLRQM 1691
V K + +V EEL + EL +++ E++T++ +E+E++ + L + +L +
Sbjct: 837 VFTKVKPLLQVTRQEEELQAKDEEL-LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ 895
Query: 1692 SKHKTEL----KNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQIS 1747
+ +TEL + + L + EL+ + + RV E E+ + EK +++ Q
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 1748 QQQKGEIEWQKQLLERDK----REIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
++Q E E +Q L+ +K +I++M E L+ KEK+ + E ++
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK-------LMEDRI 1008
Query: 1804 AQTKRVLAAAEENSK-------MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
A+ LA EE +K ++ + LE ++K ++ +L + K L + + +Q
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 1857 QQLQEKREAVNSLQEELANVQDHLN--LAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
Q+ E + ++ L+ +LA ++ L LA+ D T H++ L LQ I+E
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGD--DETLHKNNALKVVRELQAQIAELQED 1126
Query: 1915 FED-------CQKEEETKQQQLQVLQNEIEEN-KLKLVQQEMMFQRLQKERE-----SEE 1961
FE +K++ ++L+ L+ E+E+ QQE+ +R Q+ E EE
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 1962 SKLETSKVTLKEQQHQLE-KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTL 2020
+K +++ Q+H +EL++Q L+Q E+ + L+ + + K L
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQ---LEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRADF----SLLRNQF--------LTERK- 2067
Q K + + ++L + EL A E D +R + S L+N+ E+K
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 2068 -KAEKQVASLKEALKIQRSQLEKNLLEQKQENSCI---QKEMATIELVAQDNHERARRLM 2123
K K ASL+ L+ + L++ ++ +S I ++E +++ ++ E + L
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 2124 KELNQMQYEYTELKKQMANQ----KDLERRQMEISDAMRTLKSEVK------DEIRTSLK 2173
K++ +Q + + KK++ + + LE + ++ L ++ D++ +
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 2174 NLNQFLPELPADLEAILERNENLEGELESLKENLPFTMN-EGPFEEKLNFSQVHIMDEHW 2232
L Q L +L DL+ + NLE + + + L + + E+ + ++ ++
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 2233 R----GEALREKLRHRED------RLKAQLRHCMSKQAEV------LIKGKRQTEGTLHS 2276
+ AL E L +E+ +L+A + MS + +V L K KR E +
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 2277 LRRQVDAL-GELVTSTSADSASSPSLSQLESSLTEDSQL--GQNQEK 2320
+R Q++ L EL + A ++ +++ D Q QN+EK
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Score = 110 bits (276), Expect = 1e-23
Identities = 231/1064 (21%), Positives = 451/1064 (42%), Gaps = 152/1064 (14%)
Query: 55 QVEIADENNMLLDYQDHKGADSHAGVRYIT-EALIKKLTKQDNLALIKSLNLSLSKDGGK 113
Q I D L + +GA + +T EA IKK+ ++ + L++ N K+
Sbjct: 949 QAHIQDLEEQL---DEEEGARQKLQLEKVTAEAKIKKM--EEEILLLEDQNSKFIKE--- 1000
Query: 114 KFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQK 173
+K ++ + S L + EK L K+R N IS +E L+K
Sbjct: 1001 --------KKLMEDRIAECSSQLAEEEEKAKNLAKIR--NKQEVMISDLEE-----RLKK 1045
Query: 174 LNLAGNEIEHIPVWLGKKLKSLR--VLNLKGNKIS-SLQDISKLKPLQDLISL----ILV 226
E+E L + L+ + L+ LQ K + LQ ++ L
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105
Query: 227 ENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
+N + + LQ I L+ E E + + +++ E +R EE+E L+ +LE + T
Sbjct: 1106 KNNALKVVRELQAQIAELQ--EDFESEKAS-RNKAEKQKRDLSEELEALKTELEDTLDTT 1162
Query: 287 ---EELKSKQTRFL--------EEIKNQDKLNKSLK-------EEAMLQKQSCEELKSDL 328
+EL++K+ + + EE KN + + ++ EE Q + + K++L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 329 NTKNELLKQKTIELTRACQ----KQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
+ L+ EL AC+ +Q + E E K+DA+ + L+ SE + E
Sbjct: 1223 EKNKQGLETDNKEL--ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280
Query: 385 SPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEP----DEQLRNDHMNLRGHTPLDTQLE 440
K+ +N S +++ A+ IK + + QL++ L+ T L
Sbjct: 1281 -----KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 441 DKEKKISAAQTRLSELHDEIEKA----EQQILRATEEFKQLEEAIQ-----LKKISEAGK 491
+ +++ + L E +E E+A E+Q+L + ++ + ++ + EA K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 492 DLLY--KQLSGRLQ-----------LVNKLRQEALDLELQMEKQKQEIAGKQKEIK--DL 536
LL + LS RL+ N+L+QE DL + ++ Q+Q + +K+ K D
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 537 QIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLE 596
+A + S +A+ +E++ ++ L L+E L + + K L
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALS-----LARALEEALEAKEEFERQNKQLR 1510
Query: 597 EQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK---ETLLQ 651
+ + + ++ K +LE L++ + ++ Q + ++E + D K E +Q
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 652 RLTEVEQERDQLEIVAMDAENMR---KELAELESALQEQHEVNA----SLQQTQGDLSAY 704
+ + + ERD + E R K++ ELE+ L+++ + A S ++ + DL
Sbjct: 1571 AM-KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 705 EAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK 764
EA++EA AN+ ++E+ K R Q + Q ELE+ R + +++ SE+K
Sbjct: 1630 EAQIEA--------ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 765 ----EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDG----LVRPEEVAARVDEL 816
E E +L +L + +Q+ + + + + G L + AR+ +L
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 817 RRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA-RSKWERDE--AQVRERKLQEEMA 873
+L+ + N+ +D K+ + +E+ A RS ++ + Q ER+ +E A
Sbjct: 1742 EEELE--EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799
Query: 874 LQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT 933
QE + +F+ A ALEA++ + Q E ++ ++ K ++EI
Sbjct: 1800 KLQELEGAVKSKFK-ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 934 DLQLQEADEEKERI-LAQLRELEKKKKLEDAKSQ-------------------EQVFGLD 973
+ + + AD+ KE++ A R + K++LE+A+ + E GL
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Query: 974 KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAE 1017
+E+ LK + ++ + + QL L G ++++ + E
Sbjct: 1919 REVSTLKNRLRRGGPISFSSSRSGRRQL-HLEGASLELSDDDTE 1961
Score = 108 bits (270), Expect = 6e-23
Identities = 182/744 (24%), Positives = 302/744 (40%), Gaps = 152/744 (20%)
Query: 517 LQMEKQKQEIAGKQKE---IKDLQIAIDS-LDSKDPKHSHMKAQKSGKEQQLDIMNKQY- 571
LQ+ +Q++E+ K +E +K+ Q ++ L+ + KH + +K+ +QL + +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 572 -------------QQLESRLDEILSRIAKETEE--------------IKDLEEQLTEGQI 604
Q+LE L ++ SR+ +E E I+DLEEQL E +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 605 AAN--EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
A + K E I ++E + ++ Q ++ E + + D +L E E++
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 663 LEIVAMDAENMRKELAEL----ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAE 718
L + E M +L E E QE + L DL AEL+A+++ +
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 719 ANQLKEELE-----------------KVTRLTQLEQSALQAELEKERQALKNA-LGKAQF 760
+ +EEL+ KV R Q + + LQ + E E+ + A K
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 761 SEEKEQENSELHAKL-----------KHLQDDNNLLKQQLKDFQNHLNHVVDGLVRP--- 806
SEE E +EL L K Q+ L K ++ +NH + D R
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 807 -EEVAARVDELRR-KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD--EAQ 862
EE++ ++++ +R K L + + + + K LA K ++ A S+ +R +AQ
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDN----KELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 863 VRE--------RKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK------------ 902
V+E +L+ E+A + KL + E A + + F K
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 903 --------RQH---EARIQQMENEIHYLQENLKSMEEI-----QGLTDLQLQEADEEK-- 944
RQ +RI+Q+E E + LQE + EE + + LQ Q AD +K
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 945 ERILAQLRELE--KKKKLEDAKS-----QEQVFGLDKELKKLKKAVATSDKLATAELTIA 997
+ L + LE KKK L+DA++ +E+ DK L+K K + T +L
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK-LEKTKNRLQQELDDLTVDLDHQ 1439
Query: 998 KDQLKSLHGTVMKINQERAEE----LQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
+ +L K +Q AEE + AE R A+A T+A + L+ L K
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 1054 GE------QFRLEME-----KTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTG 1102
E Q R +ME K VG + L + +E RT++ L++ L T
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT- 1558
Query: 1103 SDNKGGFENVLEEIAELRREVSYQ 1126
E A+LR EV+ Q
Sbjct: 1559 ------------EDAKLRLEVNMQ 1570
Score = 101 bits (252), Expect = 7e-21
Identities = 128/556 (23%), Positives = 246/556 (44%), Gaps = 86/556 (15%)
Query: 1320 NLENEVSRLEDIMQHLKS---KKREER-WMRASKRQSEKEMEELHHNIDDLLQEKKSLEC 1375
NLE + + + ++ KS + EER A R+ E + L +++ L+ K+ E
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504
Query: 1376 EVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
+ ++L ++ KD + NV E+EKS + E V+E+ R++L
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVH------ELEKSKRALEQQVEEM----------RTQL 1548
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
E E EL T E K +E A ++ Q E D + + + +E L+K
Sbjct: 1549 EEL-------EDELQAT-EDAKLRLEVNMQAMKA--QFERDLQTRDEQNEEKKRLLIK-- 1596
Query: 1496 QQLRSLQADAKDLEQH-------KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
Q+R L+A+ +D + K K E LK++ + A + + K+ KL +++
Sbjct: 1597 -QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
Q+++E A + D KESE L++ AE+ +L Q+E+A +R H ++
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL-------QEELASSERARRHAEQ 1708
Query: 1609 ELHLLQGSMVQA---KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISE 1665
E L + + K+ L + R E + + + E +S +E L+ + + +Q+
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768
Query: 1666 RKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQG-LKLQHDQRVS 1724
+L + +K + Q + RQ + K +L+ EL+G +K + +S
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQ-----------ELEGAVKSKFKATIS 1817
Query: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
LE ++ LEE+LE E ++ + + L+ R +++++ + + VE
Sbjct: 1818 ALE-AKIGQLEEQLEQEAKERAAANK---------LVRRTEKKLKEIFMQ-------VED 1860
Query: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
+ + +E+ + ++ Q KR L AEE + ++ RKLQ+ELD
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR-------RKLQRELDDATEA 1913
Query: 1845 KLSLHNDISAMQQQLQ 1860
L ++S ++ +L+
Sbjct: 1914 NEGLSREVSTLKNRLR 1929
Score = 76.3 bits (186), Expect = 3e-13
Identities = 80/452 (17%), Positives = 192/452 (42%), Gaps = 41/452 (9%)
Query: 1320 NLENEVSRLEDIMQHL----KSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC 1375
++E+ +S +D+ +++ KSK+ E+ + + Q E+ +EL D L+ + +++
Sbjct: 1512 DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 1376 EVEELHRTVQKRQQQ----KDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKR 1431
+ R +Q R +Q K + V L ELE E+ K V + +E L
Sbjct: 1572 MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER--KQRALAVASKKKMEIDLKDL 1629
Query: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
+++ A++ E +L + + K+ + +A+ S + + ++E E++ + +
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
++ ++L S + + EQ + +E+ EI + K + L +K +L + +L+
Sbjct: 1690 LQLQEELASSERARRHAEQER---DELADEITNSASGKSA----LLDEKRRLEARIAQLE 1742
Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH 1611
+++E + N + +++ + + AEL +S L+RQ K +L
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 1612 LLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLT 1671
L+G++ + K+ + L + G+L Q+ + +
Sbjct: 1803 ELEGAVKS------------------------KFKATISALEAKIGQLEEQLEQEAKERA 1838
Query: 1672 LIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQV 1731
+ + + E+ L+ + Q+ + + ++ N ++ LK Q ++ E +
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 1732 AVLEEKLELENLQQISQQQKGEIEWQKQLLER 1763
+ + + EL++ + ++ E+ K L R
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 58.5 bits (140), Expect = 7e-08
Identities = 93/474 (19%), Positives = 193/474 (40%), Gaps = 66/474 (13%)
Query: 247 LESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKS---KQTRFLEEIKNQ 303
LE LE + T+D + E + ERDL+ + + EE K KQ R LE
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 304 DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
++ ++L A+ K+ E DL + E + E+ + + K+ A
Sbjct: 1608 ERKQRAL---AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR------------KLQA 1652
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
+ + Y E E + DE +FA ++++ + ++ E+L
Sbjct: 1653 QMKD---YQRELEEARASRDE------------IFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 424 NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
+ R + + ++ +I+ + + S L DE + E +I + EE ++ + ++L
Sbjct: 1698 SSE---RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 484 KKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS- 542
L L+ L Q++ + Q+E+Q +E+ K +++L+ A+ S
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK---LQELEGAVKSK 1811
Query: 543 ----LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
+ + + K ++ Q + ++ NK ++ E +L EI ++ E +EQ
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ 1871
Query: 599 LTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQ 658
+ + AN +K+ L+ L + +AT+A RKL+ E + + + +
Sbjct: 1872 MEK----ANARMKQ--------LKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSR 1919
Query: 659 ERDQLEIVAMDAENMRK----ELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
E L+ +R+ + S ++ H ASL+ + D + +++
Sbjct: 1920 EVSTLK------NRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 180 bits (456), Expect = 2e-44
Identities = 225/1050 (21%), Positives = 485/1050 (46%), Gaps = 126/1050 (12%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
E ++ +++ +E++ LK+K+ M + + +++ E + + + +E+K L+ E
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-E 1207
Query: 1377 VEELHRTVQKRQQQKDFI-DGNVESLMTELEIEKS---LKHHEDIVDEI--ECIEKT--- 1427
+++ T +R + +I + L T+ E++ + LK H++ +DE+ EKT
Sbjct: 1208 LQKSFET--ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265
Query: 1428 -----LLKRRSELREADRLLAEAESELSCTKE-----KTKNAVEKFTDAKRSLLQTESDA 1477
L K ++L+E +L E + L KE +T N +E T+ + T
Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325
Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK-DSDFQCL 1536
E+ER ++ +++ + Q + K L K+ + LK I + + K D + +
Sbjct: 1326 IEMER---------LRLNEKFQESQEEIKSL----TKERDNLKTIKEALEVKHDQLKEHI 1372
Query: 1537 SKKKEKLTEELQKLQKDIEMAERNED-----HHLQVLKESEVLLQAKRAELEKLKSQVTS 1591
+ K+ E K ++ + M E++ + ++ K + L E+ L ++
Sbjct: 1373 RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432
Query: 1592 QQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
EM + + +K++L LQ + L+E ++ + E ++ L+E
Sbjct: 1433 SHDEM----KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN-- 1709
EL V +SE++T+++ I++++E + LQ ++++ + K E NI + +++
Sbjct: 1489 QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE-KEEQFNIKQISEVQEKV 1547
Query: 1710 HELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE 1769
+EL+ K + S L+ ++ + LEL N Q SQ+ + Q++ ++K E++
Sbjct: 1548 NELKQFKEHRKAKDSALQ----SIESKMLELTNRLQESQE-------EIQIMIKEKEEMK 1596
Query: 1770 RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLEL 1829
R+ ALQ + L + +++ K ++K Q ++ A E KM + K +
Sbjct: 1597 RV---QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF 1653
Query: 1830 NVRKLQQELDQLNRDKLS--LHNDISAMQQQLQEKREAVNSLQEELANVQDHL------- 1880
+KL E + +L+ LH ++ M+ +E R+ + S++E L +D L
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKE-RDDLRSVEETLKVERDQLKENLRET 1712
Query: 1881 ---NLAKQDLL-----HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVL 1932
+L KQ+ L H +HQ+ + +L+ +SE N + QK+ E L+
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQETI----DKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 1933 QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQV 1992
+I+E +L++ + KE++ KL ++ ++K+L + +KL
Sbjct: 1769 DLKIQE-ELRIAHMHL------KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL--- 1818
Query: 1993 LSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK-EADSM 2051
+E+++ L+ E +L+K +++T++++SE EQ + + L L K E +++
Sbjct: 1819 -------QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENL 1871
Query: 2052 RADFSLLRNQFLTERKKAEKQVASLK---EALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
L N L E K K+ +L+ E LK++R QL+++L E K + IQ+E+ T
Sbjct: 1872 NLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
++++++ E +L +++++ + ++++K + KD +++++ VK+++
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLK-ENLPFTMNEGPFEEKLNFSQVHI 2227
S K +N+ + +L EA +NL ++S++ +N T E++ +
Sbjct: 1990 NMSHKKINE-MEQLKKQFEA-----QNL--SMQSVRMDNFQLTKKLHESLEEIRI----V 2037
Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQA---EVLIKGKRQTEGTLH---SLRRQV 2281
E ++E L+ D+ A LR +++ +V + + ++G H SLR +
Sbjct: 2038 AKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
Query: 2282 DALGELVTSTSADSASSPSLSQLESSLTED 2311
+ EL+ S L++L L ++
Sbjct: 2098 SRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127
Score = 165 bits (417), Expect = 6e-40
Identities = 221/1079 (20%), Positives = 472/1079 (43%), Gaps = 156/1079 (14%)
Query: 1323 NEVSRLEDIMQH----LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE 1378
NE+ +L++ +++ L++ +RE+ + +Q+ +E++ L DDL Q ++SL+ E +
Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946
Query: 1379 EL----HRTVQKRQQQKDFIDGNVESLMTELEIEKSLK-----------HHEDIVDEI-- 1421
+L H TV ++ + +ESL E +LK H E+ E
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
Query: 1422 ECIEKTL---LKRRSELREADRLLAEA-ESELSCTKEKTKNAVEKFTDAKRSLLQTESDA 1477
E +K + K+ E + L A+ ++E+ + K + +++ + ++ L ++
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066
Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
E+L+ +E ++ ++LR L + K KQ+EI+ + K+ + LS
Sbjct: 1067 EQLKTDLKENIEMTIENQEELRLLGDELK-------KQQEIVAQEKNHAIKKEGE---LS 1116
Query: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQ---Q 1594
+ ++L E +KL++ + + + L V +E +Q K E+E LK+++ +++ +
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE-MQKKINEIENLKNELKNKELTLE 1175
Query: 1595 EMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSF 1654
M +L K E + S+ + + L+E + ETE +IRE+++ +
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235
Query: 1655 QKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ-MSKHKTELKNILDMLQLENHELQ 1713
+ ++ + E + + +++ + E+ Q++ Q + K T+L+ + +L E L
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSV--SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293
Query: 1714 GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQK----QLLERDKREIE 1769
+K E+ +TQ + E +L E IE ++ + + + EI+
Sbjct: 1294 NVK--------EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK 1345
Query: 1770 RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEEN-SKMEQS-NLEKL 1827
+T E L++ E L + + L+E + LA +E+ SK EQS N+++
Sbjct: 1346 SLTKERDNLKTIKEALEVKHDQLKE----------HIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 1828 ELNVRKLQQELDQLN-RDKLSLHNDIS--AMQQQLQEKREAVNSLQEELANVQDHLNLAK 1884
+ K+ E++Q +D L +I + ++LQE + + S+ +E K
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-----------K 1444
Query: 1885 QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLV 1944
DL + Q+VL SE +L+++I E + + ++E + L+ + I E ++ L
Sbjct: 1445 DDL---QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501
Query: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE-KELTDQKSK--------------- 1988
++E +QK+ E+ KL+ + E++ Q K++++ + K
Sbjct: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561
Query: 1989 --LDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK 2046
L + SK+L R++ QEE + ++ + + + L QL E + E++A K
Sbjct: 1562 SALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK 1621
Query: 2047 EADSMRADF----------------SLLRNQFLTER------------------------ 2066
E+ F L+ QF T++
Sbjct: 1622 ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM 1681
Query: 2067 ---KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLM 2123
K + S++E LK++R QL++NL E + Q+E+ + + +++ E +L
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLR 1741
Query: 2124 KELNQMQYEYTELKKQMANQKD-LERRQMEISDAMRTLKSEVK------DEIRTSLKNLN 2176
+++ E + ++K + + D L+ + ++I + +R +K D++R +
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
Query: 2177 QFLPELPADLEAILERNENLEGELESLK--ENLPFTMNEGPFEEKLNFSQVHIMDEHWRG 2234
L + DLE N L+ +++ LK E+ T+ + E + S++ + + +
Sbjct: 1802 DKLSNMQKDLE---NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Query: 2235 EALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSA 2293
++L E+ AQ H ++ + ++K + +L+ + D L E + T A
Sbjct: 1859 QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917
Score = 139 bits (351), Expect = 2e-32
Identities = 212/1023 (20%), Positives = 437/1023 (42%), Gaps = 184/1023 (17%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASK----RQSEKEMEELHHNIDDLLQEKKSLECE 1376
++ V D+ + E W A+K E E+ L + D+L+ + + L E
Sbjct: 461 IDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520
Query: 1377 VEELHRTVQKRQQQKDFI--------DGNVESLMTELEIEKSLKHHE----DIVDEIECI 1424
EE+ ++++ +F D ++ + ++ +KH E D+ +E+
Sbjct: 521 KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580
Query: 1425 EKTLLKRRSELREADRL-----LAEAESELSCTKEKTKN----------AVEKFTDAKRS 1469
+ L ++ ++++ L + +LS + E ++ A DAKR
Sbjct: 581 VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
Query: 1470 LLQTESDAEELERRAQETAVNL--VKADQQLRSLQADAKDLEQHKIKQE--EILKEINKI 1525
S+ EL+ + +E A ++ D QL Q +AK Q +++E EI K+
Sbjct: 641 SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 1526 VAAKDS----DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAE 1581
+ D D C + + K+T+ ++L K++E E L+E +LL +E
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENE--------ALREEVILL----SE 748
Query: 1582 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH 1641
L+ L S+V L +++ K EELH++ + +E +
Sbjct: 749 LKSLPSEVER-------LRKEIQDKSEELHIITSEK--------------DKLFSEVVHK 787
Query: 1642 IREVKSLLEELSFQKGELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKHKTEL 1698
V+ LLEE+ K +L S K+ + K E+ ++VL + + E+
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 1699 KNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQK 1758
N+ Q + L LK + + EL++ V E E+E L K ++E +
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL-------KEQLENRD 900
Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
L+ +RE +T + + V+ L++EK+DL++
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ------------------------ 936
Query: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQD 1878
+++S LQ E DQL D +H+ ++ ++ R A+ SL++ Q+
Sbjct: 937 LQES-----------LQIERDQLKSD---IHDTVNMNIDTQEQLRNALESLKQH----QE 978
Query: 1879 HLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEE 1938
+N K + +++ + E T KD E+ + K+++ + + Q L ++++
Sbjct: 979 TINTLKSKISEEVS-RNLHMEENTGETKD--EFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035
Query: 1939 NKLKLVQQEMMFQRLQKERESEE------SKLETSKVTLKEQ-----QHQLEKELTDQKS 1987
N++ + QQ +F +Q++ E ++ ++ E K LKE ++Q E L +
Sbjct: 1036 NEI-IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094
Query: 1988 KLDQVLSKVLAAEERVRTLQEE---ERWCESL---EKTLSQTKRQLSEREQQLVEKSGEL 2041
K Q + A+E+ +++E R C+ L E+ L + +QL E++QQL+ E+
Sbjct: 1095 KKQQ----EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150
Query: 2042 LALQKEADSMRADFSLLRNQFLT----ERKKAE---------KQVASLKEALKIQRSQLE 2088
+QK+ + + + L+N+ LT E ++ E ++V S+ + K+ + +L+
Sbjct: 1151 SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-ELQ 1209
Query: 2089 KNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKE----LNQMQYEYTELKKQMANQK 2144
K+ ++ +E+ L ++ + A +KE +++++ +E Q+ N +
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 2145 DLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG------ 2198
DLE+ ++ + + L E E+ ++K +++ E +LE + E++ +
Sbjct: 1270 DLEKSHTKLQEEIPVLHEE--QELLPNVKEVSE-TQETMNELELLTEQSTTKDSTTLARI 1326
Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
E+E L+ N F ++ + + E + ++E L + D+LK +R ++K
Sbjct: 1327 EMERLRLNEKFQESQEEIKS--------LTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 2259 QAE 2261
E
Sbjct: 1379 IQE 1381
Score = 133 bits (335), Expect = 2e-30
Identities = 220/1062 (20%), Positives = 446/1062 (41%), Gaps = 170/1062 (16%)
Query: 1322 ENEVSRLEDIMQHLKSKKRE--ERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
+ E+ R+++ +Q + + +E + + K EKE + L + QEK CE+E
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM---CEIEH 1648
Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIV---DEIECIEKTLLKRRSELR 1436
L + ++ + I+ E++ + ++L+ + D++ +E+TL R +L+
Sbjct: 1649 LKEQFETQKLNLENIE--TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLK 1706
Query: 1437 EADRLLA----EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
E R E + EL K E D R ++ +++ ++ E + + +
Sbjct: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETI-DKLRGIVSEKTNEISNMQKDLEHSNDAL 1765
Query: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
KA Q L+ +Q + + H +Q+E + ++ IV+ K LS ++ L KLQ+
Sbjct: 1766 KA-QDLK-IQEELRIAHMHLKEQQETIDKLRGIVSEKTDK---LSNMQKDLENSNAKLQE 1820
Query: 1553 DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH- 1611
I+ + NE H L LK+ Q K +E+E+LK Q+ Q ++ L+ + + ++LH
Sbjct: 1821 KIQELKANE-HQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879
Query: 1612 -LLQGSMVQAKAD----LQEALRLGETEVTEKCNH-----------IREVKSLLEELSFQ 1655
L + V + D ++E L+L ++ E ++ + L +E
Sbjct: 1880 NLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKET 1939
Query: 1656 KGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL-----------KNILDM 1704
+L +ISE+ Q++ I+++++K ++ LQ ++++ K + +L K I +M
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 1705 LQLENH-ELQGLKLQ-----------------HDQRVSELEKTQVAVLEEKLELENLQQI 1746
QL+ E Q L +Q + R+ E+ ++ ++E L++E Q I
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFI 2059
Query: 1747 S--------QQQKGEIEWQKQLLE----------RDK-REIERMTAESRALQSCVECLSK 1787
+ +Q +++ +K+LL R+K I+ + + ECL++
Sbjct: 2060 ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNR 2119
Query: 1788 EKEDLQEKCDIWEKKLA------------QTKRV--LAAAEENSKMEQSNLEKLELNVRK 1833
DL+++ + ++K+L+ QTK + L A + ME + K K
Sbjct: 2120 LSLDLEKEIE-FQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMK------K 2172
Query: 1834 LQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL--LHTT 1891
L+ L + + K H I+ + ++ E L ++ ++Q ++ ++L L
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232
Query: 1892 KHQDVLLSEQTRLQKDISE-------------WANRFEDCQKEEETKQQQLQV--LQNEI 1936
++ D+ + E + KD SE +NR E Q EE + + L+N I
Sbjct: 2233 QNMDLHIEE---ILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGI 2289
Query: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLD---QVL 1993
++ ++ Q F +E ++ E T+ ++ Q K L ++ KL Q L
Sbjct: 2290 QKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTL 2349
Query: 1994 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
LA+ +V ++ + + T ++ E E L E A+ KE+
Sbjct: 2350 KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKES--AMHKES----- 2402
Query: 2054 DFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQ 2113
++ +++ L++ + K + + N C++K TI+++
Sbjct: 2403 ------------------KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD 2444
Query: 2114 DNHERARRLMKELNQMQYEYTELK-KQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSL 2172
A+ +E+ ++ + ++ ++M N K+ E+ EIS T++ + K+ IR
Sbjct: 2445 KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEK---EISATKATVEYQ-KEVIRLLR 2500
Query: 2173 KNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHW 2232
+NL + + D I E + N P T G + N + + EH
Sbjct: 2501 ENLRR--SQQAQDTSVISEHT-------DPQPSNKPLTCGGGSGIVQ-NTKALILKSEHI 2550
Query: 2233 RGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
R E KL+ + ++L Q +S + + K E TL
Sbjct: 2551 RLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTL 2592
Score = 126 bits (317), Expect = 2e-28
Identities = 225/1009 (22%), Positives = 452/1009 (44%), Gaps = 142/1009 (14%)
Query: 141 EKLDKLLKLRE-LNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLN 199
EK +LL ++E ++ KI++IE ++N ++L L E E +L+ + LN
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETE--------RLELAQKLN 1189
Query: 200 LKGNKISSLQDISK-LKPLQDLISLILVENPVVTLPHYL-QFTIFHLRSLESLEGQPVTT 257
++ S+ K LK LQ E L Y+ + L++ E L+ +
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSF-----ETERDHLRGYIREIEATGLQTKEELKIAHIHL 1244
Query: 258 QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIK---NQDKLNKSLKEEA 314
++ QE +++E+ R + ++I T++L+ T+ EEI + +L ++KE +
Sbjct: 1245 KEHQE-----TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299
Query: 315 MLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSE 374
Q ++ EL ELL +++ + E+E+ K E + E
Sbjct: 1300 ETQ-ETMNEL--------ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Query: 375 YAEIDKAPDESPYIGKSRYKRNMFATESYIIDSA--QAVQIKKMEPDEQLRNDHMNLRGH 432
+ K E+ + + K ++ T + I +S Q + E D + +
Sbjct: 1351 RDNL-KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
Query: 433 TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLK--KISEAG 490
P D+ L E ++ RL E HDE++ + + ++ ++L+E +Q + ++ E
Sbjct: 1410 KPKDSALLRIEIEMLGLSKRLQESHDEMKS----VAKEKDDLQRLQEVLQSESDQLKENI 1465
Query: 491 KDLLYKQLSGRLQL-------------VNKLR-------QEALDLELQMEKQKQEIAGKQ 530
K+++ K L +L +N+LR E ++ Q+E ++ K
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525
Query: 531 KEI--KDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
+EI K+ Q I + K + +K K ++ + + Q +ES++ E+ +R+ +
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK----DSALQSIESKMLELTNRLQES 1581
Query: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
EEI+ + ++ E + EAL+ + + + +E + +K ++ + + + K+ ET
Sbjct: 1582 QEEIQIMIKEKEEMK-RVQEALQIERDQLKENTKEIVAKMK-ESQEKEYQFLKMTAVNET 1639
Query: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
+++ E+E ++Q E ++ EN+ E L L E E S+ + + DL + E L
Sbjct: 1640 Q-EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL 1698
Query: 709 EARLNLRDAEANQLKEEL-EKVTR--LTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
+ E +QLKE L E +TR Q E + L++ ++ + G EK
Sbjct: 1699 K-------VERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRG---IVSEKT 1748
Query: 766 QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTG 825
E S + L+H N+ LK Q Q L L +E +D+LR + T
Sbjct: 1749 NEISNMQKDLEH---SNDALKAQDLKIQEELRIAHMHLKEQQET---IDKLRGIVSEKTD 1802
Query: 826 EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE 885
+++ + L S A LQ++ E+ A +E Q+ L++++ Q+K++ ++
Sbjct: 1803 KLS--NMQKDLENSNAKLQEKIQELKA------NEHQL--ITLKKDVNETQKKVSEMEQL 1852
Query: 886 FRQACERALE------ARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQE 939
+Q +++L +N ++ HE +++M++ + ++NL+ +EE L QL+E
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHE-NLEEMKS-VMKERDNLRRVEETLKLERDQLKE 1910
Query: 940 ADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKL--ATAELTIA 997
+ +E + R+LE +++L+ A+ L KE K+ T DKL +E TI
Sbjct: 1911 SLQE-----TKARDLEIQQELKTARM------LSKEHKE------TVDKLREKISEKTI- 1952
Query: 998 KDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF 1057
Q+ + + K E +++QE ++ + + D+ + +I ++ L +Q Q
Sbjct: 1953 --QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ- 2009
Query: 1058 RLEMEKTGVGTGANSQVLEIEKLNETME------RQRTEIARLQNVLDL 1100
L M+ + N Q+ +KL+E++E ++R E+ R++ L +
Sbjct: 2010 NLSMQSVRMD---NFQL--TKKLHESLEEIRIVAKERDELRRIKESLKM 2053
Score = 118 bits (296), Expect = 6e-26
Identities = 201/965 (20%), Positives = 408/965 (42%), Gaps = 126/965 (13%)
Query: 244 LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETE---------ELKSKQT 294
L +L +E P T QE E E+ L D + +++ E ELK K+
Sbjct: 476 LDTLSEIEWNPATKLLNQENIE----SELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK 531
Query: 295 RFLEEIKNQDKLNKSLKEEAMLQKQSC------------EELKSDLNTKNELLKQKTIEL 342
L+E + ++ K +E ++ + S ++L+++L++K ELL++K ++
Sbjct: 532 NDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQI 591
Query: 343 TRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATES 402
+ ++Y Q+L K+D Y E E K + K+ +F E+
Sbjct: 592 KKL--QEYIDSQKLENIKMDLS------YSLESIEDPK-----------QMKQTLFDAET 632
Query: 403 YIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEK 462
+D+ + + E E + ++ ++ + ++ A + +L E++
Sbjct: 633 VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692
Query: 463 AEQQILRATEEFKQLEEAIQLKKISEAGKDL-LYKQLSGRLQLVNKLRQEALDLELQMEK 521
A +I + T L + GK L K+L+ ++ LR+E + L +++
Sbjct: 693 AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS-ELKS 751
Query: 522 QKQEIAGKQKEIKDLQIAIDSLDS-KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDE 580
E+ +KEI+D + + S KD S + ++S + L+ + K L +
Sbjct: 752 LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811
Query: 581 ILSRIAKETEEIKDLE---EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
S +E + K L EQ + + NE + +++ + Q++ ++ T+
Sbjct: 812 YKST-DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870
Query: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQT 697
+ ++L+++ + +RL E+EQ ++QLE + + +E + LQ+ E +L Q
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930
Query: 698 QGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELE--KERQALKNAL 755
+ DL + L+ E +QLK ++ + Q L+ LE K+ Q N L
Sbjct: 931 KDDLKQLQESLQ-------IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983
Query: 756 GKAQFSEEKE-----QENS------------------ELHAK----LKHLQDDNNLLKQQ 788
K++ SEE +EN+ +L AK L DN +++QQ
Sbjct: 984 -KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1042
Query: 789 LKDF-----QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
K F +N L ++ E V A ++L+ LK EM I + ++ + L D
Sbjct: 1043 RKIFSLIQEKNELQQML------ESVIAEKEQLKTDLKENI-EMTIENQEEL--RLLGDE 1093
Query: 844 QKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKR 903
K+ EI+A+ K + + + + +A +EKL ++ ++ ++ L + +
Sbjct: 1094 LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM 1153
Query: 904 QHEA-RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQ---LRELEKKKK 959
Q + I+ ++NE+ + L+ ME + +L E EE + I + L+EL+K +
Sbjct: 1154 QKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFE 1213
Query: 960 LEDAKSQEQVFGLD-------KELK----KLKKAVATSDKL--ATAELTIAKDQLKSLHG 1006
E + + ++ +ELK LK+ T D+L + +E T + L
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK 1273
Query: 1007 TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV 1066
+ K+ +E +E E + T E E+ Q+ + R+EME+ +
Sbjct: 1274 SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333
Query: 1067 GTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
N + E ++ +++ ++R + ++ L++ K E++ E +A+++ S Q
Sbjct: 1334 ----NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK---EHIRETLAKIQESQSKQ 1386
Query: 1127 NDYIS 1131
++
Sbjct: 1387 EQSLN 1391
Score = 108 bits (270), Expect = 6e-23
Identities = 177/834 (21%), Positives = 369/834 (44%), Gaps = 117/834 (14%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEK---EMEELHHNIDDLLQEKKSLECE 1376
+LEN ++L++ +Q LK+ + + ++ +++K EME+L I D LE E
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE 1869
Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDE-IECIEKTLLKRRSEL 1435
L + + + ++ + ++L +E++LK D + E ++ + L+ + EL
Sbjct: 1870 NLNLAQKLHENLEEMKSVMKERDNLR---RVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
+ A L E + + +EK + +D ++ L + +EL+++ QE L K +
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTIQISDIQKDL---DKSKDELQKKIQE----LQKKE 1979
Query: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
QL ++ D ++ KI + E LK K A++ Q + +LT++L + ++I
Sbjct: 1980 LQLLRVKEDV-NMSHKKINEMEQLK---KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035
Query: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
+ + D L+ +KES L+ + Q + +EM DRQ K E LL
Sbjct: 2036 IVAKERDE-LRRIKES----------LKMERDQFIATLREMIARDRQNHQVKPEKRLLS- 2083
Query: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKS------------------LLEELSFQKG 1657
+ L E+LR EKC+ I+E+ L +E+ FQK
Sbjct: 2084 ---DGQQHLTESLR-------EKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK- 2132
Query: 1658 ELNVQISERKTQLTLIKQEIEKE--------------EENLQVVLRQMSKHKTELKNILD 1703
EL++++ + L + IEK + L+ VL ++K K E ++
Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESIN 2192
Query: 1704 MLQL------ENHELQGLKLQHDQRVSELEKTQVAVLE--EKLEL---ENLQQISQQQKG 1752
++ E + +K+QH Q+ ++ ++ L+ + ++L E L+ S+ +
Sbjct: 2193 KFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFP 2252
Query: 1753 EIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD-IWEKKLAQTKRVLA 1811
I+ + Q + +++E+ + E + +E K K +Q++ D I + R++A
Sbjct: 2253 SIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE---KLKNGIQKENDRICQVNNFFNNRIIA 2309
Query: 1812 AAEENSKMEQSNL---EKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ---QLQEKRE- 1864
E+++ E+ + ++ E +++ L+++ ++L ++ +L +++ Q Q+ +
Sbjct: 2310 IMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNP 2369
Query: 1865 -----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI-SEWANRFEDC 1918
A E++ +++ L+ AK+ +H + + + + ++ + DI ++ + +
Sbjct: 2370 HVTSRATQLTTEKIRELENSLHEAKESAMHK-ESKIIKMQKELEVTNDIIAKLQAKVHES 2428
Query: 1919 QKEEETKQQQLQVLQN-----------EIEENKLKLVQQEMMFQRLQKERESEESKLETS 1967
K E ++ +QVLQ+ EIE+ K+KLV+ ++ + KE E E + +
Sbjct: 2429 NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKE---ISAT 2485
Query: 1968 KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
K T+ E Q ++ + L + + Q + +E + C + TK +
Sbjct: 2486 KATV-EYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI 2544
Query: 2028 SEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK 2081
+ E +EK L Q E + + L NQ L+ K K+ +EA K
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHK 2598
Score = 107 bits (267), Expect = 1e-22
Identities = 214/1061 (20%), Positives = 435/1061 (40%), Gaps = 162/1061 (15%)
Query: 57 EIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFK 116
E+ ++ N L +++H+ A A +++ K+ + N + + ++ K
Sbjct: 1542 EVQEKVNELKQFKEHRKAKDSA-----LQSIESKMLELTNRLQESQEEIQIMIKEKEEMK 1596
Query: 117 YIENLEKCVKLEVLNLSYNLIGKI----EKLDKLLKLRELNLSYNKISKIEGIENMCNLQ 172
++ + + ++ + ++ K+ EK + LK+ +N + K+ +IE ++ Q
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656
Query: 173 KLNLAGNEIEHIPVW--LGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPV 230
KLNL E E+I + L + L+ +R + + + + S+++ K++ +D + L E
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE--RDQLKENLRETIT 1714
Query: 231 VTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELK 290
L + I H+ E E T D+ E+ +++DLE + LK
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQE-----TIDKLRGIVSEKTNEISNMQKDLEHS---NDALK 1766
Query: 291 SKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQY 350
++ + EE++ + LKE Q+++ ++L+ ++ K + L +L + K
Sbjct: 1767 AQDLKIQEELRIA---HMHLKE----QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819
Query: 351 ELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQA 410
E QEL A L + E K E + K +++ ++ I + A
Sbjct: 1820 EKIQELK-----ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 411 VQI-KKMEPDEQLRNDHMNLRG-HTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
++ + +E + + + NLR L + + ++ + + R E+ E++ A
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSK 1934
Query: 469 RATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAG 528
E +L E I K I + + K L + K QE ELQ+ + K+++
Sbjct: 1935 EHKETVDKLREKISEKTIQISD---IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991
Query: 529 KQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRI--- 585
K+I +++ +K Q + + + QL +L E L I
Sbjct: 1992 SHKKINEME--------------QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037
Query: 586 AKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE 645
AKE +E++ ++E +LK + + I+ L+E + + Q Q + E R L D
Sbjct: 2038 AKERDELRRIKE-----------SLKMERDQFIATLREMIARDR-QNHQVKPEKRLLSDG 2085
Query: 646 KE--------------TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVN 691
++ LL+R +E++ + L +++D E KE+ E + L + + N
Sbjct: 2086 QQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE---KEI-EFQKELSMRVKAN 2141
Query: 692 ASLQ--QTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
SL QT+ + A + +LK L VT++ KE Q
Sbjct: 2142 LSLPYLQTKHIEKLFTANQRCSMEFHRI-MKKLKYVLSYVTKI-------------KEEQ 2187
Query: 750 ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDF---QN---HLNHVVDGL 803
+ F +E E++ EL K++HLQ D ++ ++L+D QN H+ ++
Sbjct: 2188 HESINKFEMDFIDEVEKQK-ELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDF 2246
Query: 804 VRPE---------EVAARVDELRR-------------KLKLGTGEMN--IHSPSDVLGKS 839
E +V + E+ + KLK G + N I ++
Sbjct: 2247 SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNR 2306
Query: 840 LADLQKQFSEILARS-----KWERDEAQVRER--KLQEEMALQQEKLATGQEEFRQACER 892
+ + + +E RS +WE+D ++E+ KL + + LA+G + +
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366
Query: 893 ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLR 952
+ + +I+++EN +H +E+ A ++ +I+ +
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKES-----------------AMHKESKIIKMQK 2409
Query: 953 ELEKKKKLEDAKSQEQVFGLDKELKKLKKAV-ATSDKLATAELTIAKDQLKSLHGTVMKI 1011
ELE + AK Q +V +K L+K K+ + DK+A AK + + MK+
Sbjct: 2410 ELEVTNDI-IAKLQAKVHESNKCLEKTKETIQVLQDKVALG----AKPYKEEIEDLKMKL 2464
Query: 1012 NQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQ 1052
+ E+++ A+ F ++ + + + I LL+ LR+
Sbjct: 2465 VKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
Score = 75.9 bits (185), Expect = 4e-13
Identities = 140/689 (20%), Positives = 282/689 (40%), Gaps = 134/689 (19%)
Query: 1315 VPEHHNLENE-VSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNI-------DDL 1366
V E N+ ++ ++ +E + + +++ + +R Q K++ E I D+L
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044
Query: 1367 LQEKKSLECEVEELHRTV-----------QKRQQQKDFIDGN---VESLMTELE-IEKSL 1411
+ K+SL+ E ++ T+ Q + +++ DG ESL + I++ L
Sbjct: 2045 RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104
Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
K + ++ D EC+ + L E+ L ++ LS +TK+ + FT +R +
Sbjct: 2105 KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM 2164
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
+ ++K + + S K+ EQH + INK +
Sbjct: 2165 EFH---------------RIMKKLKYVLSYVTKIKE-EQH--------ESINKF----EM 2196
Query: 1532 DFQCLSKKKEKLTEELQKLQKDIEMAER---------NEDHHLQVLKESEVLLQAKRAEL 1582
DF +K+++L ++Q LQ+D ++ R N D H++ E+L +E
Sbjct: 2197 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIE-----EILKDFSESEF 2251
Query: 1583 EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHI 1642
+K++ + L ++KE L+ + + D+ E L+ G + ++ + I
Sbjct: 2252 PSIKTE----------FQQVLSNRKEMTQFLE-EWLNTRFDI-EKLKNG---IQKENDRI 2296
Query: 1643 REVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL 1702
+V + + + ER I +E E++ ++L+ ++ K+ LK L
Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFEERS---ATISKEWEQDLKSLKEKNEKLFKNYQTLKTSL 2353
Query: 1703 DMLQLENHELQGLKLQH-DQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
N Q K H R ++L ++ LE L E + ++ I+ QK+ L
Sbjct: 2354 ASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH-EAKESAMHKESKIIKMQKE-L 2411
Query: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
E I ++ A+ + +CL K KE +Q + Q K L A ++E
Sbjct: 2412 EVTNDIIAKLQAK---VHESNKCLEKTKETIQ---------VLQDKVALGAKPYKEEIED 2459
Query: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
++ +++++ K+ ++ +ISA + ++ ++E + L+E L Q
Sbjct: 2460 LKMKLVKIDLEKM--------KNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQ--- 2508
Query: 1882 LAKQDLLHTTKHQD-----------------------VLLSEQTRLQKDISEWANRFEDC 1918
QD ++H D +L SE RL+K+IS+ + E
Sbjct: 2509 --AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL 2566
Query: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
K++ Q L NE++ K + +++E
Sbjct: 2567 IKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
Score = 70.5 bits (171), Expect = 2e-11
Identities = 159/773 (20%), Positives = 313/773 (40%), Gaps = 135/773 (17%)
Query: 474 FKQLEEAIQLKKISEAGKDLLY-KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKE 532
F + A+Q ++ K+ Y ++S L+ + R+E +DL+ Q+E+ E + E
Sbjct: 313 FDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAME 372
Query: 533 IKDLQIAIDSLD-------SKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRI 585
L ++ D K + M S Q ++ K+ +++ L +I
Sbjct: 373 KDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMK 432
Query: 586 AKETEEIKDLEEQLTEGQIAANEALKKDL-EGVISGLQEYLGTIKGQATQAQNECRKLRD 644
+ ++ +T + L +++ E V S + T+ + N KL +
Sbjct: 433 NSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLN 492
Query: 645 EKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH---EVNASLQQTQGDL 701
+ E + L + + D L +D E +R E E+E L+E++ E A ++T+ D
Sbjct: 493 Q-ENIESELNSLRADYDNL---VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548
Query: 702 SA----------------------YEAELEARLNLRDAEANQLKE--------------- 724
E EL +++ L + +Q+K+
Sbjct: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608
Query: 725 ----ELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780
LE + Q++Q+ AE ++A +++ E KE + EL K +++
Sbjct: 609 DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKE-KMKELATTYKQMEN 667
Query: 781 DNNLLKQQL-----------KDFQNHLNHV------VDGLVRPE-----EVAARVDELRR 818
D L + QL K+ Q+ N + +DG V + E+ ++ +L++
Sbjct: 668 DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 819 KLKLGTGE--------------MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
+L E ++ S + L K + D ++ I + E +
Sbjct: 728 ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 865 ERKLQ---EEMALQQEKLATGQEEFR---QACERALEARMNFDKRQHEA--RIQQMENEI 916
E ++Q EE+ ++ LAT Q ++ Q + M+F+++ ++M EI
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 917 HYLQENLKSMEEIQGLTDLQL----QEADEEKERILAQLRELEK-KKKLEDAKSQEQVF- 970
L + + + G +L QE E+ + +L E+E+ K++LE+ S Q
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 971 --------GLDKELKKLKKAVATSDKLATAE--LTIAKDQLKS-LHGTVMKINQERAEEL 1019
L + L+++K D L + L I +DQLKS +H TV +N + E+L
Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV-NMNIDTQEQL 966
Query: 1020 QEAERFSRKAAQAARDLTRAEAEIELLQNL-LRQKGEQFRLEMEKTGVG-------TGAN 1071
+ A S K Q + +++ E+ +NL + + + + E ++ VG N
Sbjct: 967 RNALE-SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 1072 SQVLEIE-KLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREV 1123
+Q L + K NE +E+QR + +Q +L + E+V+ E +L+ ++
Sbjct: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNEL-----QQMLESVIAEKEQLKTDL 1073
Score = 43.9 bits (102), Expect = 0.002
Identities = 66/315 (20%), Positives = 147/315 (46%), Gaps = 29/315 (9%)
Query: 1914 RFEDCQKEEETKQQQLQVLQNEIEENKL-KLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
R E +++ ++ L+ +E+++L +L++++ + Q++Q E+ +++ + +L
Sbjct: 349 RKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLT 408
Query: 1973 EQQH---QLEKELTDQKSKLDQVLSKVLAAEERVRT-------------LQEEERWCESL 2016
QQ + ++ +T K++++ + A + + T L+E + S
Sbjct: 409 LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSE 468
Query: 2017 EKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLL---RNQFLTERKKAE--- 2070
S T LSE E K ++ E +S+RAD+ L Q TE+++ E
Sbjct: 469 SDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL 528
Query: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 2130
K+ L E ++R + ++ E S ++ + E+ QD ++ L + +
Sbjct: 529 KEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588
Query: 2131 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAIL 2190
+ +L++ + +QK LE +M++S ++ ++ E +++ +L + L A E+
Sbjct: 589 DQIKKLQEYIDSQK-LENIKMDLSYSLESI--EDPKQMKQTLFDAETV--ALDAKRESAF 643
Query: 2191 ERNENLEGELESLKE 2205
R+ENLE + E +KE
Sbjct: 644 LRSENLELK-EKMKE 657
Score = 36.6 bits (83), Expect = 0.30
Identities = 99/569 (17%), Positives = 221/569 (38%), Gaps = 79/569 (13%)
Query: 57 EIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFK 116
++ E +L D Q H I E L + D+ + L+L L K+ +
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE----IE 2129
Query: 117 YIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNL 176
+ + L VK L+L Y IEKL + ++ +++I K
Sbjct: 2130 FQKELSMRVKAN-LSLPYLQTKHIEKL--FTANQRCSMEFHRIMK--------------- 2171
Query: 177 AGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHY 236
+++++ ++ K+K + ++ ++ + ++ K K L ++ + H
Sbjct: 2172 ---KLKYVLSYV-TKIKEEQHESINKFEMDFIDEVEKQKEL------------LIKIQHL 2215
Query: 237 LQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRF 296
Q R L L+ +E + FS E ++ + ++ + +E+ T+F
Sbjct: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEM----TQF 2271
Query: 297 LEEIKNQ----DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYEL 352
LEE N +KL +++E + C+ N ++ + T R+ E
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKE---NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEW 2328
Query: 353 EQELAFYK-----IDAKFEPLNYYPSEYAEIDKAPDES--PYIGKSRYK---RNMFATES 402
EQ+L K + ++ L + A+++ ++ P++ + + E+
Sbjct: 2329 EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELEN 2388
Query: 403 YIIDSAQAVQIK-----KMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELH 457
+ ++ ++ K KM+ + ++ ND + L ++ + K + + + L
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDII-----AKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 458 DEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLEL 517
D++ + E+ K I L+K+ A + K++S V ++ L
Sbjct: 2444 DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE--FEKEISATKATVEYQKEVIRLLRE 2501
Query: 518 QMEKQKQ--------EIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK 569
+ + +Q E Q K L S ++ K +K++ E+++ + +
Sbjct: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQ 2561
Query: 570 QYQQLESRLDEILSRIAKETEEIKDLEEQ 598
Q +QL + +E+LS + E+K +E+
Sbjct: 2562 QNEQLIKQKNELLSNNQHLSNEVKTWKER 2590
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 177 bits (448), Expect = 1e-43
Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)
Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
L++ + + + DE++ ++ K +EL+E ++ ++ E + +E+ + E +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
+A+ ++ + +ELE E L + + + + LQA+ K + Q + EE L+E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
+ K+ A D LSK+++ L E + L ++ E
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
++ H ++ E EV L + R ELEKLK Q+ Q ++A L Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
L K+EEL + A AL+ ++ E HI +++ L+ + + Q
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
+ +L +K E+E ++ Q + + + T LK LD + +HE +Q ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1199
Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
+H Q V EL + K L+ +Q +++ ++ + ++L + K+E+E ++ A
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
+ + LQS + + +L +K + ++ +L AE + ++ L ++
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
Q+ L + R KL+ L + +++Q QL E+ EA +L+ ++ + L+ +K+
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
L + L + R QK+I ++E+ + ++ LQ E+++ + L Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
+ L+K++ + L K + + ++ + + K + LS A EE +
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
+E ER LEK+ + Q+ E + QL E EL A +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
+ + L+ QF + + ++Q + L+ Q + E L +++++ +
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
++ ++ +EL A + +K+L ++Q + + ++++ +
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
+ DL + Q +++ A R K E+ +E+ +SL N E L A +
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
+ E E +G +E++ + + + E+L+ + E+ R++L +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
L+++L + E +K K + T+ +L ++ L E V + + A++ SL Q +
Sbjct: 1797 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 2307 SLTE 2310
L E
Sbjct: 1850 KLKE 1853
Score = 160 bits (405), Expect = 1e-38
Identities = 201/1045 (19%), Positives = 453/1045 (43%), Gaps = 126/1045 (12%)
Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
D+ + L+ ++ + ++ K +E ++++L I DD L +E+K LE + +L
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
+ + +++ + ES+++ELE+ LK E E+E +++ L
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
++++ E LA+ E EL + + + + +A + + + E +L+
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
KA++Q R L ++LE K + E+ L ++ A ++ + L K ++ T
Sbjct: 1132 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
++Q++++ A L+ K ++ L + LEK + + + + + +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
++ HKK++L Q +Q+K E R + K N + V +L E + +L
Sbjct: 1249 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
++ +QL ++ Q +L++ ++ K + L L+ E + LQ D
Sbjct: 1308 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1350
Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
Q E+E Q LE + N+Q ++K L+ +E + + Q
Sbjct: 1351 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1399
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
+E L+++ E+ D KL +TK L ++ ++ N +L N+ K Q++ DQ
Sbjct: 1400 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
L ++ ++ + + + + + + + LA + AK++L T K + +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
+ D+ + + E ++ ET+ + QL+ L++E+ E+ KL+L V + + +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
+++ ++ + + E + L+ Q H+ E EL D+ K KL+ L + L A+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
++ +E + L+ + +R+L + E +K+A S+ AD L+
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
L + + AE+ +SL + AL+ ++ +LE + + ++E +++E +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1752
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
E ++ + ++ + N++ E + +K + ++ LER+ E+ + ++ VK +
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
++++ L + +L +E + + +SLK+ ++KL + +
Sbjct: 1813 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1859
Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
DE E +E+ R+K + +Q E + ++ L+R++D
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1908
Query: 2289 TSTSADSASSPSLSQLESSLTEDSQ 2313
+T ++ A ++ L+S L ++
Sbjct: 1909 EATESNEAMGREVNALKSKLRRGNE 1933
Score = 135 bits (340), Expect = 5e-31
Identities = 193/934 (20%), Positives = 393/934 (42%), Gaps = 137/934 (14%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
S + ++ LK +++ + + KR+ E + + H I DL + ++ EL +
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-------QAQIAELKMQLA 1086
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
K++++ ++ + + +LK ++ I +++ L R+ +A++ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKN--NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 1446 ESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA 1505
EL K T+ + +L T + E +R QE V D++ RS +A
Sbjct: 1145 GEELEALK----------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 1506 KDLEQ-HKIKQEEILKEINKIVAAK---DSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 1561
+++ Q H EE+ +++ + AK D + Q L K+ L EL+ L + A++
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----AKQEV 1250
Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQ----QQEMAVLDRQLGHKKEELHLLQGSM 1617
+H + L+ LQ+K ++ E+ ++++ + Q E+ + L + + L +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
+ LQ+ L + E +K N V + L +L ++ L Q+ E KQ +
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEA----KQNL 1362
Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENH----ELQGLKLQHDQRVS---ELEKTQ 1730
E+ L + L K + + ++ L+ E++ L Q++++ + +LEKT+
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1731 VAVLEEK----LELENLQQ-ISQQQKGEIEWQKQLLE-----------RDKREIERMTAE 1774
+ +E ++L+N +Q +S +K + ++ + L E RD+ E E E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 1775 S------RALQSCVEC----------LSKEKEDL-QEKCDIWEK--KLAQTKRVLAAAEE 1815
+ RAL+ +E L E EDL K D+ + +L ++KR L E
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 1816 NSKMEQSNLE-----------KLELNVRKLQ-------QELDQLNRDKL-SLHNDISAMQ 1856
K + LE +LE+N++ L+ Q D+ N +K L + +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
+L+++R+ ++ L + K ++ + + +LQ + ++ E
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 1917 DCQ----------KEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE----- 1961
D + KE E K + L+ +++E+ L ++ L+KE +EE
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQED-LAAAERARKQADLEKEELAEELASSL 1721
Query: 1962 ---SKLETSKVTLKEQQHQLEKELTDQKSKL----DQVLSKVLAAEERVRTLQEEERWCE 2014
+ L+ K L+ + QLE+EL +++ + D+V AE+ L E +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA-DSMRADFSLLRNQFLTERKKAEKQV 2073
E Q +RQ E +L E G + + K ++ A + L Q E ++ +
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 2074 ASLKEALKIQRSQL-----EKNLLEQKQENS--------CIQKEMATIELVAQDNHERAR 2120
SLK+ K + L E+ + EQ +E + +++++ E +Q + R
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 2121 RLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
+L +EL++ + +++ K RR E S
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935
Score = 134 bits (336), Expect = 1e-30
Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)
Query: 285 ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
+ EE+++K+ + + Q K LKE Q EE L+ L + EL +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 342 LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
R K+ ELE+ L ++++A+ E
Sbjct: 910 RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 935
Query: 402 SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
D Q +Q ++ + +Q+ + L+ QLE++E +K+ A+ ++
Sbjct: 936 ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
+L DEI + Q + ++E K LEE I + A ++ K L+ +L NK +
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1038
Query: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
LE++++K+++ ++E++ L+ ++ D+ D ++Q L
Sbjct: 1039 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1074
Query: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
++++ E+ ++AK+ EE++ +L + N ALKK +LEG IS LQE L + +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
+A+ + R L +E E L TE+E D +E+ L+ AL E
Sbjct: 1135 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1185
Query: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
+ ++EA+++ +L E+LE+ R +A L+K +Q L
Sbjct: 1186 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1229
Query: 753 NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
E+EN++L +L+ ++ L+ Q+++ Q+ + DG
Sbjct: 1230 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1274
Query: 806 PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
E+ +V +L+ +++ TG +N + L K +A L Q E+L ++
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 862 QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
+ R+L+EE Q++L + E +Q ER + + +N + ++Q + + L+E
Sbjct: 1335 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 922 NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
K + EI+ LT ++ E A +LEK K + + V LD + +
Sbjct: 1393 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 978 KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
L+K D+L E I+ K ER EA KA AR L
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1493
Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
A EA+ EL + K E L K VG + L ME +T++ L++
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
L T KG FE L E+ E RR++ Q ++Y + + D K+R
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Score = 131 bits (329), Expect = 9e-30
Identities = 218/976 (22%), Positives = 424/976 (43%), Gaps = 126/976 (12%)
Query: 247 LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
++ LE + + D+ ER LEE + L +L E+K +LK+K + E+
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 301 KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
+ + K + ++E K+ E SD + + L+ + EL K+ E E + A +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1098
Query: 361 IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
+D + N + E++ D + R RN E D + ++ K E +
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1156
Query: 420 EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
+ L + T +L K E++++ + L E H+ ++++ Q+ +A EE
Sbjct: 1157 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 475 -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
+QLE+ + K + K L K+ L+G L+++ + +QE + ++E Q QE+ K
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268
Query: 530 ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
++ +L + L ++ + M + GK +L D+ ++ Q Q + L E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 583 SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
+ + +++ LEE+ Q +E + K++LE IS L L K +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 635 AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
A E +K + E E L Q+ E D+LE +++EL +L L Q ++ ++
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 694 LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
L++ Q L A E + ++ + RD + +E+ K L + + AL+A+ E ER
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 750 ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
N + KA+ E+ ++ + L+ L+ Q+++ + L + D L E+
Sbjct: 1506 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
R++ + LK G E ++ + + + LQ+Q E LA + +
Sbjct: 1562 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Query: 858 RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
+ E +++ +LQ + A+ Q KL ++F++ E A +R +++E
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
+ + +E ++ LQE+L + E + DL+ +E E EK R+ A++ +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 954 LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
LE ++LE+ + + D+ K ++A S++LAT T K+ +L
Sbjct: 1741 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
+S LH T+ + + A+ ++ E+ +R+ A + L + + EI L
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
R+ EQ++ + EK G Q+ ++E+ E +R +LQ LD N
Sbjct: 1858 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 1106 KGGFENVLEEIAELRR 1121
+ V ++LRR
Sbjct: 1915 EAMGREVNALKSKLRR 1930
Score = 130 bits (328), Expect = 1e-29
Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)
Query: 247 LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
+++ E + T++RQ+ E L+E+E+ L E+K + E+L+++ + E + + +
Sbjct: 854 MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 306 LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
L +E EA L+++ E+ L + + + Q+ ++L +++ Q+L
Sbjct: 913 LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
K+ A+ A+I K DE K +R + + + A +
Sbjct: 971 LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 414 KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
+K + +L+N H ++ + + E+K EK + S+ H++I + QI
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 469 RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
+ + EE +Q LKKI E + L + L NK +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 511 EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
+ DL ++E K E+ A +++E+ L+ A+D S + + M+
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
+ + ++L +Q+++ ++ LD+ + KE ++ K LE
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 598 QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
Q+ E + + E + +L + LQ + ++ G +A+ + KL + +L +L +
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 656 ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
+++E Q V+ + +E L+ L E+ E +N L ++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 701 LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
L + + +EA L + E ++LEK Q E L +L+ +
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 748 RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
RQ + N E+K+++ +L A+ K++ D+ + + + ++ + + L
Sbjct: 1440 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 804 VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
EE +EL R K+ EM ++ S D +GK++ +L+K S+ ++ E + Q
Sbjct: 1493 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1547
Query: 863 VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
+ E L++E+ ++ +L + + ER L+AR Q+E + +Q++ ++H
Sbjct: 1548 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1601
Query: 920 QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
+ L+ + ++++G L DL+LQ A + +E + QLR+L+ + K L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 961 EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
EDA+ S++++F KE +K K++ +L A+ K ++ +E A L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
E R + AQ +L + +E + + +R Q+ EQ E+
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1775
Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
S + E + +ERQ E+ ++L + S K + +IA+L +V +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Score = 101 bits (251), Expect = 1e-20
Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)
Query: 563 QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
Q+ ++ Q E L + R K E+K+LE+ QLTE + E L+ + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 901
Query: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
+ +A + + + E E +L + +E+E D+ + + + + M +++
Sbjct: 902 --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
+LE L+E+ LQ + A +LE + + D + N+L +E E+++ LT
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 735 --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
E+ L K + ++ + + + +KE+++ + KLK L+ D + +Q+ D
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 792 FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
Q + + L + EE +A DE+ +K N L ++DLQ+
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1126
Query: 847 F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
SE AR+K E+ + + E L+ E+ + AT Q+E R E+ L+ ++
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1185
Query: 901 DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
+ R HEA++Q+M + + L E L+ + + D Q ++E + +LR L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 957 KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
K+ + K ++ L+ ++++L+ + ++ A AEL D++ L V +
Sbjct: 1246 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1293
Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
L EAE KA + A+D+ ++++ Q LL+++ Q K V T E
Sbjct: 1294 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1344
Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
L + ++ + + + R + L++ SD+K ++ + L I ++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 1134 ADPFKRRGYWY 1144
++ + Y
Sbjct: 1405 TQQYEEKAAAY 1415
Score = 97.4 bits (241), Expect = 1e-19
Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)
Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
+++ L Q+++Q++ E++ ++ L++ K ++ E + L+ L++EK LQE+
Sbjct: 840 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
+ A+ + + + + L ++E + + + QL ++ + + +++Q
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
L+E+ A LQ E + + + ++L + L E+ L++ IS+
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1015
Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
EEE K + L L+N+ I E +++L ++E Q L+K + E + L
Sbjct: 1016 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
+ LK Q + E+EL ++LD L K+ E + LQE+ +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
+ KR L E + L +E + + A Q+E + R + ++L+ E + E QV
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
+++ +L + L + K+ + + K T+E ++N + A L + L Q + E
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1250
Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
KK++ Q D ER + E++D + L++EV + + L +L D
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1309
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
+ ++ + L+ E L+E +N +L + + D+ ++ L
Sbjct: 1310 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
L QL K E L +GK++ + + +L +Q + +
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
L L L QL N EK
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEK 1448
Score = 96.7 bits (239), Expect = 2e-19
Identities = 128/549 (23%), Positives = 234/549 (42%), Gaps = 133/549 (24%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
+E+ VS +D+ +++ + SKR E +MEE ++ ++EEL
Sbjct: 1513 MEDLVSSKDDVGKNVHE-------LEKSKRALETQMEE--------------MKTQLEEL 1551
Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
+Q + K ++ N+++L + E + + ++ + R+ R
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---------------EEKRRQLQR 1596
Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
L E E+EL +++ A AK+ L E D ++LE +A +A +QLR
Sbjct: 1597 QLHEYETELEDERKQRALAAA----AKKKL---EGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 1501 LQADAKD----LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
LQA KD LE + ++EI AK+++ KK + L +L +LQ+D+
Sbjct: 1650 LQAQMKDFQRELEDARASRDEI------FATAKENE-----KKAKSLEADLMQLQEDLAA 1698
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
AER K+A+LEK +E+A EEL S
Sbjct: 1699 AER----------------ARKQADLEK---------EELA----------EEL----AS 1719
Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
+ + LQ+ R E + + + E + +E +S + + Q + +L +
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736
+K E Q + RQ + +++L HE++G V K+ +A LE
Sbjct: 1780 AQKNESARQQLERQNKELRSKL-----------HEMEG-------AVKSKFKSTIAALEA 1821
Query: 1737 KL-ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
K+ +LE +Q+ Q+ + + K L ++DK+ E + VE K E +E+
Sbjct: 1822 KIAQLE--EQVEQEAREKQAATKSLKQKDKKLKEILLQ--------VEDERKMAEQYKEQ 1871
Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
+ ++ Q KR L AEE S +++ N RKLQ+ELD+ ++ +++A+
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEES-------QRINANRRKLQRELDEATESNEAMGREVNAL 1924
Query: 1856 QQQLQEKRE 1864
+ +L+ E
Sbjct: 1925 KSKLRRGNE 1933
Score = 81.6 bits (200), Expect = 8e-15
Identities = 117/551 (21%), Positives = 239/551 (43%), Gaps = 73/551 (13%)
Query: 265 ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
+R + +E+ +R ++ + E + + SK R E + ++K K+L L++
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1496
Query: 323 ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
E K +L N++LK + +L + + EL K ++ + E + E + +
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 381 APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
A +++ K R + NM A + QA + E QL+ R +T+LE
Sbjct: 1557 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1606
Query: 441 DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
D+ K+ + A +L +++ E L+A K EEAI QL+K+ KD +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 500 GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
R N+ + ++L+ ++LQ + E A KQ +++ ++A + S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
+++ ++ +K E ++ + ++ ++ + ++ + R+ K T++ + L +L + A
Sbjct: 1724 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 607 NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
NE+ ++ LE + S L E G +K +A + Q +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 641 KLRDEKETLLQRLTEVEQERDQLEIVAMDAEN----MRKELAELESALQEQHEVNASLQQ 696
L+ + + L + L +VE ER E AE +++ +LE A +E +NA+ ++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 697 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALG 756
Q +L EA E N LK +L + E S + + R+ ++NA G
Sbjct: 1903 LQRELDEATESNEAM----GREVNALKSKLRRGN-----ETSFVPSRRSGGRRVIENADG 1953
Query: 757 KAQFSEEKEQE 767
+ ++ ++ +
Sbjct: 1954 SEEETDTRDAD 1964
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 177 bits (448), Expect = 1e-43
Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)
Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
L++ + + + DE++ ++ K +EL+E ++ ++ E + +E+ + E +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
+A+ ++ + +ELE E L + + + + LQA+ K + Q + EE L+E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
+ K+ A D LSK+++ L E + L ++ E
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
++ H ++ E EV L + R ELEKLK Q+ Q ++A L Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
L K+EEL + A AL+ ++ E HI +++ L+ + + Q
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
+ +L +K E+E ++ Q + + + T LK LD + +HE +Q ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1206
Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
+H Q V EL + K L+ +Q +++ ++ + ++L + K+E+E ++ A
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
+ + LQS + + +L +K + ++ +L AE + ++ L ++
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
Q+ L + R KL+ L + +++Q QL E+ EA +L+ ++ + L+ +K+
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
L + L + R QK+I ++E+ + ++ LQ E+++ + L Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
+ L+K++ + L K + + ++ + + K + LS A EE +
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
+E ER LEK+ + Q+ E + QL E EL A +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
+ + L+ QF + + ++Q + L+ Q + E L +++++ +
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
++ ++ +EL A + +K+L ++Q + + ++++ +
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
+ DL + Q +++ A R K E+ +E+ +SL N E L A +
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
+ E E +G +E++ + + + E+L+ + E+ R++L +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
L+++L + E +K K + T+ +L ++ L E V + + A++ SL Q +
Sbjct: 1804 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 2307 SLTE 2310
L E
Sbjct: 1857 KLKE 1860
Score = 160 bits (405), Expect = 1e-38
Identities = 201/1045 (19%), Positives = 453/1045 (43%), Gaps = 126/1045 (12%)
Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
D+ + L+ ++ + ++ K +E ++++L I DD L +E+K LE + +L
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
+ + +++ + ES+++ELE+ LK E E+E +++ L
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
++++ E LA+ E EL + + + + +A + + + E +L+
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
KA++Q R L ++LE K + E+ L ++ A ++ + L K ++ T
Sbjct: 1139 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
++Q++++ A L+ K ++ L + LEK + + + + + +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
++ HKK++L Q +Q+K E R + K N + V +L E + +L
Sbjct: 1256 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
++ +QL ++ Q +L++ ++ K + L L+ E + LQ D
Sbjct: 1315 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1357
Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
Q E+E Q LE + N+Q ++K L+ +E + + Q
Sbjct: 1358 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1406
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
+E L+++ E+ D KL +TK L ++ ++ N +L N+ K Q++ DQ
Sbjct: 1407 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
L ++ ++ + + + + + + + LA + AK++L T K + +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
+ D+ + + E ++ ET+ + QL+ L++E+ E+ KL+L V + + +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
+++ ++ + + E + L+ Q H+ E EL D+ K KL+ L + L A+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
++ +E + L+ + +R+L + E +K+A S+ AD L+
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
L + + AE+ +SL + AL+ ++ +LE + + ++E +++E +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1759
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
E ++ + ++ + N++ E + +K + ++ LER+ E+ + ++ VK +
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
++++ L + +L +E + + +SLK+ ++KL + +
Sbjct: 1820 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1866
Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
DE E +E+ R+K + +Q E + ++ L+R++D
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1915
Query: 2289 TSTSADSASSPSLSQLESSLTEDSQ 2313
+T ++ A ++ L+S L ++
Sbjct: 1916 EATESNEAMGREVNALKSKLRRGNE 1940
Score = 135 bits (340), Expect = 5e-31
Identities = 193/934 (20%), Positives = 393/934 (42%), Gaps = 137/934 (14%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
S + ++ LK +++ + + KR+ E + + H I DL + ++ EL +
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-------QAQIAELKMQLA 1093
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
K++++ ++ + + +LK ++ I +++ L R+ +A++ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKN--NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 1446 ESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA 1505
EL K T+ + +L T + E +R QE V D++ RS +A
Sbjct: 1152 GEELEALK----------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 1506 KDLEQ-HKIKQEEILKEINKIVAAK---DSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 1561
+++ Q H EE+ +++ + AK D + Q L K+ L EL+ L + A++
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----AKQEV 1257
Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQ----QQEMAVLDRQLGHKKEELHLLQGSM 1617
+H + L+ LQ+K ++ E+ ++++ + Q E+ + L + + L +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
+ LQ+ L + E +K N V + L +L ++ L Q+ E KQ +
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEA----KQNL 1369
Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENH----ELQGLKLQHDQRVS---ELEKTQ 1730
E+ L + L K + + ++ L+ E++ L Q++++ + +LEKT+
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1731 VAVLEEK----LELENLQQ-ISQQQKGEIEWQKQLLE-----------RDKREIERMTAE 1774
+ +E ++L+N +Q +S +K + ++ + L E RD+ E E E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 1775 S------RALQSCVEC----------LSKEKEDL-QEKCDIWEK--KLAQTKRVLAAAEE 1815
+ RAL+ +E L E EDL K D+ + +L ++KR L E
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 1816 NSKMEQSNLE-----------KLELNVRKLQ-------QELDQLNRDKL-SLHNDISAMQ 1856
K + LE +LE+N++ L+ Q D+ N +K L + +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
+L+++R+ ++ L + K ++ + + +LQ + ++ E
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 1917 DCQ----------KEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE----- 1961
D + KE E K + L+ +++E+ L ++ L+KE +EE
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQED-LAAAERARKQADLEKEELAEELASSL 1728
Query: 1962 ---SKLETSKVTLKEQQHQLEKELTDQKSKL----DQVLSKVLAAEERVRTLQEEERWCE 2014
+ L+ K L+ + QLE+EL +++ + D+V AE+ L E +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA-DSMRADFSLLRNQFLTERKKAEKQV 2073
E Q +RQ E +L E G + + K ++ A + L Q E ++ +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 2074 ASLKEALKIQRSQL-----EKNLLEQKQENS--------CIQKEMATIELVAQDNHERAR 2120
SLK+ K + L E+ + EQ +E + +++++ E +Q + R
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 2121 RLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
+L +EL++ + +++ K RR E S
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942
Score = 134 bits (336), Expect = 1e-30
Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)
Query: 285 ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
+ EE+++K+ + + Q K LKE Q EE L+ L + EL +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 342 LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
R K+ ELE+ L ++++A+ E
Sbjct: 917 RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 942
Query: 402 SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
D Q +Q ++ + +Q+ + L+ QLE++E +K+ A+ ++
Sbjct: 943 ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
+L DEI + Q + ++E K LEE I + A ++ K L+ +L NK +
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1045
Query: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
LE++++K+++ ++E++ L+ ++ D+ D ++Q L
Sbjct: 1046 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1081
Query: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
++++ E+ ++AK+ EE++ +L + N ALKK +LEG IS LQE L + +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
+A+ + R L +E E L TE+E D +E+ L+ AL E
Sbjct: 1142 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1192
Query: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
+ ++EA+++ +L E+LE+ R +A L+K +Q L
Sbjct: 1193 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1236
Query: 753 NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
E+EN++L +L+ ++ L+ Q+++ Q+ + DG
Sbjct: 1237 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1281
Query: 806 PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
E+ +V +L+ +++ TG +N + L K +A L Q E+L ++
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 862 QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
+ R+L+EE Q++L + E +Q ER + + +N + ++Q + + L+E
Sbjct: 1342 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 922 NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
K + EI+ LT ++ E A +LEK K + + V LD + +
Sbjct: 1400 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 978 KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
L+K D+L E I+ K ER EA KA AR L
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1500
Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
A EA+ EL + K E L K VG + L ME +T++ L++
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
L T KG FE L E+ E RR++ Q ++Y + + D K+R
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Score = 131 bits (329), Expect = 9e-30
Identities = 218/976 (22%), Positives = 424/976 (43%), Gaps = 126/976 (12%)
Query: 247 LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
++ LE + + D+ ER LEE + L +L E+K +LK+K + E+
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 301 KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
+ + K + ++E K+ E SD + + L+ + EL K+ E E + A +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1105
Query: 361 IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
+D + N + E++ D + R RN E D + ++ K E +
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1163
Query: 420 EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
+ L + T +L K E++++ + L E H+ ++++ Q+ +A EE
Sbjct: 1164 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 475 -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
+QLE+ + K + K L K+ L+G L+++ + +QE + ++E Q QE+ K
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275
Query: 530 ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
++ +L + L ++ + M + GK +L D+ ++ Q Q + L E
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 583 SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
+ + +++ LEE+ Q +E + K++LE IS L L K +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 635 AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
A E +K + E E L Q+ E D+LE +++EL +L L Q ++ ++
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 694 LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
L++ Q L A E + ++ + RD + +E+ K L + + AL+A+ E ER
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 750 ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
N + KA+ E+ ++ + L+ L+ Q+++ + L + D L E+
Sbjct: 1513 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
R++ + LK G E ++ + + + LQ+Q E LA + +
Sbjct: 1569 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627
Query: 858 RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
+ E +++ +LQ + A+ Q KL ++F++ E A +R +++E
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
+ + +E ++ LQE+L + E + DL+ +E E EK R+ A++ +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 954 LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
LE ++LE+ + + D+ K ++A S++LAT T K+ +L
Sbjct: 1748 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
+S LH T+ + + A+ ++ E+ +R+ A + L + + EI L
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
R+ EQ++ + EK G Q+ ++E+ E +R +LQ LD N
Sbjct: 1865 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 1106 KGGFENVLEEIAELRR 1121
+ V ++LRR
Sbjct: 1922 EAMGREVNALKSKLRR 1937
Score = 130 bits (328), Expect = 1e-29
Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)
Query: 247 LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
+++ E + T++RQ+ E L+E+E+ L E+K + E+L+++ + E + + +
Sbjct: 861 MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 306 LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
L +E EA L+++ E+ L + + + Q+ ++L +++ Q+L
Sbjct: 920 LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
K+ A+ A+I K DE K +R + + + A +
Sbjct: 978 LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 414 KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
+K + +L+N H ++ + + E+K EK + S+ H++I + QI
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 469 RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
+ + EE +Q LKKI E + L + L NK +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 511 EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
+ DL ++E K E+ A +++E+ L+ A+D S + + M+
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
+ + ++L +Q+++ ++ LD+ + KE ++ K LE
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 598 QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
Q+ E + + E + +L + LQ + ++ G +A+ + KL + +L +L +
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 656 ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
+++E Q V+ + +E L+ L E+ E +N L ++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 701 LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
L + + +EA L + E ++LEK Q E L +L+ +
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 748 RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
RQ + N E+K+++ +L A+ K++ D+ + + + ++ + + L
Sbjct: 1447 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 804 VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
EE +EL R K+ EM ++ S D +GK++ +L+K S+ ++ E + Q
Sbjct: 1500 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1554
Query: 863 VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
+ E L++E+ ++ +L + + ER L+AR Q+E + +Q++ ++H
Sbjct: 1555 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1608
Query: 920 QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
+ L+ + ++++G L DL+LQ A + +E + QLR+L+ + K L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 961 EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
EDA+ S++++F KE +K K++ +L A+ K ++ +E A L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
E R + AQ +L + +E + + +R Q+ EQ E+
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1782
Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
S + E + +ERQ E+ ++L + S K + +IA+L +V +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Score = 101 bits (251), Expect = 1e-20
Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)
Query: 563 QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
Q+ ++ Q E L + R K E+K+LE+ QLTE + E L+ + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 908
Query: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
+ +A + + + E E +L + +E+E D+ + + + + M +++
Sbjct: 909 --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
+LE L+E+ LQ + A +LE + + D + N+L +E E+++ LT
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 735 --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
E+ L K + ++ + + + +KE+++ + KLK L+ D + +Q+ D
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 792 FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
Q + + L + EE +A DE+ +K N L ++DLQ+
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1133
Query: 847 F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
SE AR+K E+ + + E L+ E+ + AT Q+E R E+ L+ ++
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1192
Query: 901 DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
+ R HEA++Q+M + + L E L+ + + D Q ++E + +LR L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 957 KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
K+ + K ++ L+ ++++L+ + ++ A AEL D++ L V +
Sbjct: 1253 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1300
Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
L EAE KA + A+D+ ++++ Q LL+++ Q K V T E
Sbjct: 1301 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1351
Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
L + ++ + + + R + L++ SD+K ++ + L I ++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 1134 ADPFKRRGYWY 1144
++ + Y
Sbjct: 1412 TQQYEEKAAAY 1422
Score = 97.4 bits (241), Expect = 1e-19
Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)
Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
+++ L Q+++Q++ E++ ++ L++ K ++ E + L+ L++EK LQE+
Sbjct: 847 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
+ A+ + + + + L ++E + + + QL ++ + + +++Q
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
L+E+ A LQ E + + + ++L + L E+ L++ IS+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1022
Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
EEE K + L L+N+ I E +++L ++E Q L+K + E + L
Sbjct: 1023 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
+ LK Q + E+EL ++LD L K+ E + LQE+ +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
+ KR L E + L +E + + A Q+E + R + ++L+ E + E QV
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
+++ +L + L + K+ + + K T+E ++N + A L + L Q + E
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1257
Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
KK++ Q D ER + E++D + L++EV + + L +L D
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1316
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
+ ++ + L+ E L+E +N +L + + D+ ++ L
Sbjct: 1317 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
L QL K E L +GK++ + + +L +Q + +
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
L L L QL N EK
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEK 1455
Score = 96.7 bits (239), Expect = 2e-19
Identities = 128/549 (23%), Positives = 234/549 (42%), Gaps = 133/549 (24%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
+E+ VS +D+ +++ + SKR E +MEE ++ ++EEL
Sbjct: 1520 MEDLVSSKDDVGKNVHE-------LEKSKRALETQMEE--------------MKTQLEEL 1558
Query: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
+Q + K ++ N+++L + E + + ++ + R+ R
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---------------EEKRRQLQR 1603
Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
L E E+EL +++ A AK+ L E D ++LE +A +A +QLR
Sbjct: 1604 QLHEYETELEDERKQRALAAA----AKKKL---EGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 1501 LQADAKD----LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
LQA KD LE + ++EI AK+++ KK + L +L +LQ+D+
Sbjct: 1657 LQAQMKDFQRELEDARASRDEI------FATAKENE-----KKAKSLEADLMQLQEDLAA 1705
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
AER K+A+LEK +E+A EEL S
Sbjct: 1706 AER----------------ARKQADLEK---------EELA----------EEL----AS 1726
Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
+ + LQ+ R E + + + E + +E +S + + Q + +L +
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736
+K E Q + RQ + +++L HE++G V K+ +A LE
Sbjct: 1787 AQKNESARQQLERQNKELRSKL-----------HEMEG-------AVKSKFKSTIAALEA 1828
Query: 1737 KL-ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
K+ +LE +Q+ Q+ + + K L ++DK+ E + VE K E +E+
Sbjct: 1829 KIAQLE--EQVEQEAREKQAATKSLKQKDKKLKEILLQ--------VEDERKMAEQYKEQ 1878
Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
+ ++ Q KR L AEE S +++ N RKLQ+ELD+ ++ +++A+
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEES-------QRINANRRKLQRELDEATESNEAMGREVNAL 1931
Query: 1856 QQQLQEKRE 1864
+ +L+ E
Sbjct: 1932 KSKLRRGNE 1940
Score = 81.6 bits (200), Expect = 8e-15
Identities = 117/551 (21%), Positives = 239/551 (43%), Gaps = 73/551 (13%)
Query: 265 ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
+R + +E+ +R ++ + E + + SK R E + ++K K+L L++
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1503
Query: 323 ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
E K +L N++LK + +L + + EL K ++ + E + E + +
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 381 APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
A +++ K R + NM A + QA + E QL+ R +T+LE
Sbjct: 1564 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1613
Query: 441 DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
D+ K+ + A +L +++ E L+A K EEAI QL+K+ KD +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 500 GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
R N+ + ++L+ ++LQ + E A KQ +++ ++A + S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
+++ ++ +K E ++ + ++ ++ + ++ + R+ K T++ + L +L + A
Sbjct: 1731 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 607 NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
NE+ ++ LE + S L E G +K +A + Q +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 641 KLRDEKETLLQRLTEVEQERDQLEIVAMDAEN----MRKELAELESALQEQHEVNASLQQ 696
L+ + + L + L +VE ER E AE +++ +LE A +E +NA+ ++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 697 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALG 756
Q +L EA E N LK +L + E S + + R+ ++NA G
Sbjct: 1910 LQRELDEATESNEAM----GREVNALKSKLRRGN-----ETSFVPSRRSGGRRVIENADG 1960
Query: 757 KAQFSEEKEQE 767
+ ++ ++ +
Sbjct: 1961 SEEETDTRDAD 1971
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 177 bits (448), Expect = 1e-43
Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)
Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
L++ + + + DE++ ++ K +EL+E ++ ++ E + +E+ + E +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
+A+ ++ + +ELE E L + + + + LQA+ K + Q + EE L+E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
+ K+ A D LSK+++ L E + L ++ E
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
++ H ++ E EV L + R ELEKLK Q+ Q ++A L Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
L K+EEL + A AL+ ++ E HI +++ L+ + + Q
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
+ +L +K E+E ++ Q + + + T LK LD + +HE +Q ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1206
Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
+H Q V EL + K L+ +Q +++ ++ + ++L + K+E+E ++ A
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
+ + LQS + + +L +K + ++ +L AE + ++ L ++
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
Q+ L + R KL+ L + +++Q QL E+ EA +L+ ++ + L+ +K+
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
L + L + R QK+I ++E+ + ++ LQ E+++ + L Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
+ L+K++ + L K + + ++ + + K + LS A EE +
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
+E ER LEK+ + Q+ E + QL E EL A +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
+ + L+ QF + + ++Q + L+ Q + E L +++++ +
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
++ ++ +EL A + +K+L ++Q + + ++++ +
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
+ DL + Q +++ A R K E+ +E+ +SL N E L A +
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
+ E E +G +E++ + + + E+L+ + E+ R++L +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
L+++L + E +K K + T+ +L ++ L E V + + A++ SL Q +
Sbjct: 1804 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 2307 SLTE 2310
L E
Sbjct: 1857 KLKE 1860
Score = 160 bits (404), Expect = 2e-38
Identities = 201/1040 (19%), Positives = 451/1040 (43%), Gaps = 126/1040 (12%)
Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
D+ + L+ ++ + ++ K +E ++++L I DD L +E+K LE + +L
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
+ + +++ + ES+++ELE+ LK E E+E +++ L
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
++++ E LA+ E EL + + + + +A + + + E +L+
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
KA++Q R L ++LE K + E+ L ++ A ++ + L K ++ T
Sbjct: 1139 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
++Q++++ A L+ K ++ L + LEK + + + + + +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
++ HKK++L Q +Q+K E R + K N + V +L E + +L
Sbjct: 1256 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
++ +QL ++ Q +L++ ++ K + L L+ E + LQ D
Sbjct: 1315 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1357
Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
Q E+E Q LE + N+Q ++K L+ +E + + Q
Sbjct: 1358 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1406
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
+E L+++ E+ D KL +TK L ++ ++ N +L N+ K Q++ DQ
Sbjct: 1407 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
L ++ ++ + + + + + + + LA + AK++L T K + +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
+ D+ + + E ++ ET+ + QL+ L++E+ E+ KL+L V + + +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
+++ ++ + + E + L+ Q H+ E EL D+ K KL+ L + L A+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
++ +E + L+ + +R+L + E +K+A S+ AD L+
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
L + + AE+ +SL + AL+ ++ +LE + + ++E +++E +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1759
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
E ++ + ++ + N++ E + +K + ++ LER+ E+ + ++ VK +
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
++++ L + +L +E + + +SLK+ ++KL + +
Sbjct: 1820 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1866
Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
DE E +E+ R+K + +Q E + ++ L+R++D
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1915
Query: 2289 TSTSADSASSPSLSQLESSL 2308
+T ++ A ++ L+S L
Sbjct: 1916 EATESNEAMGREVNALKSKL 1935
Score = 134 bits (336), Expect = 1e-30
Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)
Query: 285 ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
+ EE+++K+ + + Q K LKE Q EE L+ L + EL +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 342 LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
R K+ ELE+ L ++++A+ E
Sbjct: 917 RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 942
Query: 402 SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
D Q +Q ++ + +Q+ + L+ QLE++E +K+ A+ ++
Sbjct: 943 ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
+L DEI + Q + ++E K LEE I + A ++ K L+ +L NK +
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1045
Query: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
LE++++K+++ ++E++ L+ ++ D+ D ++Q L
Sbjct: 1046 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1081
Query: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
++++ E+ ++AK+ EE++ +L + N ALKK +LEG IS LQE L + +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
+A+ + R L +E E L TE+E D +E+ L+ AL E
Sbjct: 1142 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1192
Query: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
+ ++EA+++ +L E+LE+ R +A L+K +Q L
Sbjct: 1193 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1236
Query: 753 NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
E+EN++L +L+ ++ L+ Q+++ Q+ + DG
Sbjct: 1237 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1281
Query: 806 PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
E+ +V +L+ +++ TG +N + L K +A L Q E+L ++
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 862 QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
+ R+L+EE Q++L + E +Q ER + + +N + ++Q + + L+E
Sbjct: 1342 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 922 NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
K + EI+ LT ++ E A +LEK K + + V LD + +
Sbjct: 1400 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 978 KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
L+K D+L E I+ K ER EA KA AR L
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1500
Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
A EA+ EL + K E L K VG + L ME +T++ L++
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
L T KG FE L E+ E RR++ Q ++Y + + D K+R
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Score = 130 bits (328), Expect = 1e-29
Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)
Query: 247 LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
+++ E + T++RQ+ E L+E+E+ L E+K + E+L+++ + E + + +
Sbjct: 861 MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 306 LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
L +E EA L+++ E+ L + + + Q+ ++L +++ Q+L
Sbjct: 920 LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
K+ A+ A+I K DE K +R + + + A +
Sbjct: 978 LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 414 KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
+K + +L+N H ++ + + E+K EK + S+ H++I + QI
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 469 RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
+ + EE +Q LKKI E + L + L NK +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 511 EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
+ DL ++E K E+ A +++E+ L+ A+D S + + M+
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
+ + ++L +Q+++ ++ LD+ + KE ++ K LE
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 598 QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
Q+ E + + E + +L + LQ + ++ G +A+ + KL + +L +L +
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 656 ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
+++E Q V+ + +E L+ L E+ E +N L ++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 701 LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
L + + +EA L + E ++LEK Q E L +L+ +
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 748 RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
RQ + N E+K+++ +L A+ K++ D+ + + + ++ + + L
Sbjct: 1447 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 804 VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
EE +EL R K+ EM ++ S D +GK++ +L+K S+ ++ E + Q
Sbjct: 1500 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1554
Query: 863 VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
+ E L++E+ ++ +L + + ER L+AR Q+E + +Q++ ++H
Sbjct: 1555 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1608
Query: 920 QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
+ L+ + ++++G L DL+LQ A + +E + QLR+L+ + K L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 961 EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
EDA+ S++++F KE +K K++ +L A+ K ++ +E A L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
E R + AQ +L + +E + + +R Q+ EQ E+
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1782
Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
S + E + +ERQ E+ ++L + S K + +IA+L +V +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Score = 129 bits (325), Expect = 3e-29
Identities = 214/961 (22%), Positives = 418/961 (43%), Gaps = 126/961 (13%)
Query: 247 LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
++ LE + + D+ ER LEE + L +L E+K +LK+K + E+
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 301 KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
+ + K + ++E K+ E SD + + L+ + EL K+ E E + A +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1105
Query: 361 IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
+D + N + E++ D + R RN E D + ++ K E +
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1163
Query: 420 EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
+ L + T +L K E++++ + L E H+ ++++ Q+ +A EE
Sbjct: 1164 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 475 -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
+QLE+ + K + K L K+ L+G L+++ + +QE + ++E Q QE+ K
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275
Query: 530 ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
++ +L + L ++ + M + GK +L D+ ++ Q Q + L E
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 583 SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
+ + +++ LEE+ Q +E + K++LE IS L L K +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 635 AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
A E +K + E E L Q+ E D+LE +++EL +L L Q ++ ++
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 694 LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
L++ Q L A E + ++ + RD + +E+ K L + + AL+A+ E ER
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 750 ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
N + KA+ E+ ++ + L+ L+ Q+++ + L + D L E+
Sbjct: 1513 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
R++ + LK G E ++ + + + LQ+Q E LA + +
Sbjct: 1569 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627
Query: 858 RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
+ E +++ +LQ + A+ Q KL ++F++ E A +R +++E
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
+ + +E ++ LQE+L + E + DL+ +E E EK R+ A++ +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 954 LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
LE ++LE+ + + D+ K ++A S++LAT T K+ +L
Sbjct: 1748 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
+S LH T+ + + A+ ++ E+ +R+ A + L + + EI L
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
R+ EQ++ + EK G Q+ ++E+ E +R +LQ LD N
Sbjct: 1865 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 1106 K 1106
+
Sbjct: 1922 E 1922
Score = 129 bits (324), Expect = 3e-29
Identities = 221/1024 (21%), Positives = 443/1024 (43%), Gaps = 145/1024 (14%)
Query: 85 EALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLD 144
EA IKKL +D + ++ N LSK+ K ++ + +L+ NL + EK
Sbjct: 984 EAKIKKL--EDEILVMDDQNNKLSKE-----------RKLLEERISDLTTNLAEEEEKAK 1030
Query: 145 KLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNK 204
L KL+ N + IS++E L+K + E+E + L +
Sbjct: 1031 NLTKLK--NKHESMISELE-----VRLKKEEKSRQELEKLKRKLEGDASDFH------EQ 1077
Query: 205 ISSLQ-DISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
I+ LQ I++LK +Q ++ + L + L+ + LEG Q+ ++
Sbjct: 1078 IADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 264 FERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323
ER + + E+ +RDL + E E LK++ L+ Q +L ++E + K++ +E
Sbjct: 1137 -ERAARNKAEKQKRDLGE---ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 324 LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD 383
+ + ++QK + +Q E F + A + N E D A
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLE-----QFKRAKANLDK-NKQTLEKENADLA-G 1245
Query: 384 ESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE 443
E +G+++ Q V+ KK + L+ Q+++ +
Sbjct: 1246 ELRVLGQAK----------------QEVEHKKKK-----------------LEAQVQELQ 1272
Query: 444 KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE-EAIQLKK----ISEAGKD---LLY 495
K S + +EL+D++ K + ++ T + E +AI+L K +S +D LL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 496 KQLSGRLQLVNKLRQ---EALDLELQMEKQKQEIAGKQKEIKDLQIAI-DSLDSKDPKHS 551
++ +L + KLRQ E L+ Q++++ + ++ I L I + DS S
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 552 HMKAQKSGK---EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL-TEGQIAAN 607
++A + GK +++++ + +QY++ + D++ + +E+ DL L + Q+ +N
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 608 -EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI- 665
E ++ + +++ + + +A+ E R+ + +L + L E + +++LE
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 666 ----------VAMDAENMRKELAELES---ALQEQ-HEVNASLQQTQGDLSAYE-AELEA 710
+ +++ K + ELE AL+ Q E+ L++ + +L A E A+L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 711 RLNL--------RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE 762
+N+ RD +A + E ++ QL + + E E++++AL A K +
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 763 EKE---QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK 819
K+ Q +S + + + ++ L + Q+KDFQ L D +E+ A E +K
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELE---DARASRDEIFATAKENEKK 1688
Query: 820 LKLGTGEMNIHSPSDVLG----KSLADLQKQ-FSEILARSKWERDEAQVRERKLQEEMAL 874
K ++ + D+ + ADL+K+ +E LA S R+ Q +R+L+ +A
Sbjct: 1689 AKSLEADL-MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 875 QQEKLATGQEEFRQACERALEARMNFDK------------RQHEARIQQMENEIHYLQEN 922
+E+L Q +R +A ++ +++E+ QQ+E + L+
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Query: 923 LKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKA 982
L ME G + + E +AQL E +++ E + + + DK+LK++
Sbjct: 1808 LHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 983 VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
V K+A K+Q + + V ++ ++ E +E++R + + R+L A
Sbjct: 1865 VEDERKMAEQY----KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 1043 IELL 1046
E +
Sbjct: 1921 NEAM 1924
Score = 103 bits (258), Expect = 2e-21
Identities = 139/642 (21%), Positives = 279/642 (43%), Gaps = 134/642 (20%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
S+L+D + L+ + R++ + RQ E+E L +D+ ++ K++LE + L+ +
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 1386 KRQQQKDFIDGNVESL-----MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL----- 1435
+++ VE+L + EIE + +E+ + +EKT + + EL
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1436 ----------------READRLLAEAE------------SELSCTKEKTK-----NAVEK 1462
R+ D+LLAE + +E +++TK A+E+
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 1463 FTDAKRSLLQT----ESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI 1518
+AK L +T +++ E+L + N+ + ++ R+L+ +E+ K + EE+
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEEL 1558
Query: 1519 LKEINKIVAAK--------------DSDFQCLSKKKEKLTEELQKL--QKDIEMAERNED 1562
E+ AK + D Q ++ E+ +LQ+ + + E+ + +
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 1563 HHLQVLKE-------SEVLLQAKRA---------ELEKLKSQVTSQQQEM----AVLDRQ 1602
L + ++ LQA A +L KL++Q+ Q+E+ A D
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1603 LGHKKE---ELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
KE + L+ ++Q + DL A R + EK + L EEL+
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-------EELAEELASSLSGR 1731
Query: 1660 NVQISERK---TQLTLIKQEIEKEEENLQVV---LRQMSKHKTELKNIL----------- 1702
N E++ ++ +++E+E+E+ N++ + +R+ ++ +L N L
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1703 ---DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL-ELENLQQISQQQKGEIEWQK 1758
L+ +N EL+ + + V K+ +A LE K+ +LE +Q+ Q+ + + K
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE--EQVEQEAREKQAATK 1849
Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
L ++DK+ E + VE K E +E+ + ++ Q KR L AEE S
Sbjct: 1850 SLKQKDKKLKEILLQ--------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES- 1900
Query: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
+++ N RKLQ+ELD+ ++ +++A++ +L+
Sbjct: 1901 ------QRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 101 bits (251), Expect = 1e-20
Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)
Query: 563 QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
Q+ ++ Q E L + R K E+K+LE+ QLTE + E L+ + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 908
Query: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
+ +A + + + E E +L + +E+E D+ + + + + M +++
Sbjct: 909 --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
+LE L+E+ LQ + A +LE + + D + N+L +E E+++ LT
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 735 --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
E+ L K + ++ + + + +KE+++ + KLK L+ D + +Q+ D
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 792 FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
Q + + L + EE +A DE+ +K N L ++DLQ+
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1133
Query: 847 F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
SE AR+K E+ + + E L+ E+ + AT Q+E R E+ L+ ++
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1192
Query: 901 DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
+ R HEA++Q+M + + L E L+ + + D Q ++E + +LR L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 957 KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
K+ + K ++ L+ ++++L+ + ++ A AEL D++ L V +
Sbjct: 1253 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1300
Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
L EAE KA + A+D+ ++++ Q LL+++ Q K V T E
Sbjct: 1301 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1351
Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
L + ++ + + + R + L++ SD+K ++ + L I ++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 1134 ADPFKRRGYWY 1144
++ + Y
Sbjct: 1412 TQQYEEKAAAY 1422
Score = 97.4 bits (241), Expect = 1e-19
Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)
Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
+++ L Q+++Q++ E++ ++ L++ K ++ E + L+ L++EK LQE+
Sbjct: 847 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
+ A+ + + + + L ++E + + + QL ++ + + +++Q
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
L+E+ A LQ E + + + ++L + L E+ L++ IS+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1022
Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
EEE K + L L+N+ I E +++L ++E Q L+K + E + L
Sbjct: 1023 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
+ LK Q + E+EL ++LD L K+ E + LQE+ +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
+ KR L E + L +E + + A Q+E + R + ++L+ E + E QV
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
+++ +L + L + K+ + + K T+E ++N + A L + L Q + E
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1257
Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
KK++ Q D ER + E++D + L++EV + + L +L D
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1316
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
+ ++ + L+ E L+E +N +L + + D+ ++ L
Sbjct: 1317 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
L QL K E L +GK++ + + +L +Q + +
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
L L L QL N EK
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEK 1455
Score = 77.8 bits (190), Expect = 1e-13
Identities = 111/510 (21%), Positives = 221/510 (43%), Gaps = 68/510 (13%)
Query: 265 ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
+R + +E+ +R ++ + E + + SK R E + ++K K+L L++
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1503
Query: 323 ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
E K +L N++LK + +L + + EL K ++ + E + E + +
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 381 APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
A +++ K R + NM A + QA + E QL+ R +T+LE
Sbjct: 1564 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1613
Query: 441 DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
D+ K+ + A +L +++ E L+A K EEAI QL+K+ KD +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 500 GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
R N+ + ++L+ ++LQ + E A KQ +++ ++A + S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
+++ ++ +K E ++ + ++ ++ + ++ + R+ K T++ + L +L + A
Sbjct: 1731 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 607 NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
NE+ ++ LE + S L E G +K +A + Q +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 641 KLRDEKETLLQRLTEVEQERDQLEIVAMDAE----NMRKELAELESALQEQHEVNASLQQ 696
L+ + + L + L +VE ER E AE +++ +LE A +E +NA+ ++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 697 TQGDLSAYEAELEARLNLRDAEANQLKEEL 726
Q +L EA E N LK +L
Sbjct: 1910 LQRELDEATESNEA----MGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 177 bits (448), Expect = 1e-43
Identities = 204/1024 (19%), Positives = 432/1024 (42%), Gaps = 133/1024 (12%)
Query: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
L++ + + + DE++ ++ K +EL+E ++ ++ E + +E+ + E +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE--- 1521
+A+ ++ + +ELE E L + + + + LQA+ K + Q + EE L+E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 1522 ------INKIVA------------AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN--- 1560
+ K+ A D LSK+++ L E + L ++ E
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 1561 ----EDHHLQVLKESEVLL---QAKRAELEKLK-----------SQVTSQQQEMAVLDRQ 1602
++ H ++ E EV L + R ELEKLK Q+ Q ++A L Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
L K+EEL + A AL+ ++ E HI +++ L+ + + Q
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1663 ISERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHE--LQGLKL 1717
+ +L +K E+E ++ Q + + + T LK LD + +HE +Q ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQ 1199
Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTA 1773
+H Q V EL + K L+ +Q +++ ++ + ++L + K+E+E ++ A
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 1774 ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK 1833
+ + LQS + + +L +K + ++ +L AE + ++ L ++
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 1834 LQQELDQLNRDKLS-------LHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
Q+ L + R KL+ L + +++Q QL E+ EA +L+ ++ + L+ +K+
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
L + L + R QK+I ++E+ + ++ LQ E+++ + L Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
+ L+K++ + L K + + ++ + + K + LS A EE +
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 2007 QEEERW---------------------CESLEKTLSQTKRQLSEREQQLVEKSGELLALQ 2045
+E ER LEK+ + Q+ E + QL E EL A +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 2046 KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC----- 2100
+ + L+ QF + + ++Q + L+ Q + E L +++++ +
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 2101 --IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN---------------- 2142
++ ++ +EL A + +K+L ++Q + + ++++ +
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 2143 ------QKDLERRQMEISDAMRTL------KSEVKDEIRTSLKNLNQFLPE---LPADLE 2187
+ DL + Q +++ A R K E+ +E+ +SL N E L A +
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 2188 AILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
+ E E +G +E++ + + + E+L+ + E+ R++L +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQA---EQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSAD-SASSPSLSQLES 2306
L+++L + E +K K + T+ +L ++ L E V + + A++ SL Q +
Sbjct: 1797 LRSKLH-----EMEGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 2307 SLTE 2310
L E
Sbjct: 1850 KLKE 1853
Score = 160 bits (404), Expect = 2e-38
Identities = 201/1040 (19%), Positives = 451/1040 (43%), Gaps = 126/1040 (12%)
Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNI---DD----LLQEKKSLECEVEELHR 1382
D+ + L+ ++ + ++ K +E ++++L I DD L +E+K LE + +L
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 1383 TVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTL----------- 1428
+ + +++ + ES+++ELE+ LK E E+E +++ L
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
++++ E LA+ E EL + + + + +A + + + E +L+
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI---NKIVAAKDSDFQCLSKKKEKLTE 1545
KA++Q R L ++LE K + E+ L ++ A ++ + L K ++ T
Sbjct: 1132 AARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 1546 ----ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
++Q++++ A L+ K ++ L + LEK + + + + + +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
++ HKK++L Q +Q+K E R + K N + V +L E + +L
Sbjct: 1249 EVEHKKKKLE-AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
++ +QL ++ Q +L++ ++ K + L L+ E + LQ D
Sbjct: 1308 KDVASLSSQL-----------QDTQELLQEETRQKLNVSTKLRQLEEERNSLQ------D 1350
Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
Q E+E Q LE + N+Q ++K L+ +E + + Q
Sbjct: 1351 QLDEEMEAKQ--NLERHISTLNIQLSDSKKK---------LQDFASTVEALEEGKKRFQK 1399
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
+E L+++ E+ D KL +TK L ++ ++ N +L N+ K Q++ DQ
Sbjct: 1400 EIENLTQQYEEKAAAYD----KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
L ++ ++ + + + + + + + LA + AK++L T K + +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 1901 QTRLQKDISEWANRFEDCQKEEETKQQ----QLQVLQNEI---EENKLKL-VQQEMMFQR 1952
+ D+ + + E ++ ET+ + QL+ L++E+ E+ KL+L V + + +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 1953 LQKERESEESKLETSKVTLKEQQHQLEKELTDQ----------KSKLDQVLSKV-LAAEE 2001
+++ ++ + + E + L+ Q H+ E EL D+ K KL+ L + L A+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
++ +E + L+ + +R+L + E +K+A S+ AD L+
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 2062 F-----------LTERKKAEKQVASL--KEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
L + + AE+ +SL + AL+ ++ +LE + + ++E +++E +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM 1752
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
E ++ + ++ + N++ E + +K + ++ LER+ E+ + ++ VK +
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
++++ L + +L +E + + +SLK+ ++KL + +
Sbjct: 1813 KSTIAALEAKIAQLEEQVE---QEAREKQAATKSLKQK----------DKKLKEILLQVE 1859
Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
DE E +E+ R+K + +Q E + ++ L+R++D
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANRRKLQRELD------ 1908
Query: 2289 TSTSADSASSPSLSQLESSL 2308
+T ++ A ++ L+S L
Sbjct: 1909 EATESNEAMGREVNALKSKL 1928
Score = 134 bits (336), Expect = 1e-30
Identities = 206/899 (22%), Positives = 371/899 (41%), Gaps = 179/899 (19%)
Query: 285 ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIE 341
+ EE+++K+ + + Q K LKE Q EE L+ L + EL +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 342 LTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE 401
R K+ ELE+ L ++++A+ E
Sbjct: 910 RVRLAAKKQELEEIL--HEMEARLEEEE-------------------------------- 935
Query: 402 SYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE---KKIS----AAQTRLS 454
D Q +Q ++ + +Q+ + L+ QLE++E +K+ A+ ++
Sbjct: 936 ----DRGQQLQAERKKMAQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
+L DEI + Q + ++E K LEE I + A ++ K L+ +L NK +
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT---KLKNKHESMISE 1038
Query: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
LE++++K+++ ++E++ L+ ++ D+ D ++Q L
Sbjct: 1039 LEVRLKKEEK----SRQELEKLKRKLEG-DASD-------------------FHEQIADL 1074
Query: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQEYLGTIKGQA 632
++++ E+ ++AK+ EE++ +L + N ALKK +LEG IS LQE L + +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
+A+ + R L +E E L TE+E D +E+ L+ AL E
Sbjct: 1135 NKAEKQKRDLGEELEAL---KTELEDTLDSTATQQELRAKREQEVTVLKKALDE------ 1185
Query: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
+ ++EA+++ +L E+LE+ R +A L+K +Q L
Sbjct: 1186 -------ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR--------AKANLDKNKQTL- 1229
Query: 753 NALGKAQFSEEKEQENSELHAKLK-------HLQDDNNLLKQQLKDFQNHLNHVVDGLVR 805
E+EN++L +L+ ++ L+ Q+++ Q+ + DG
Sbjct: 1230 ------------EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS---DGERA 1274
Query: 806 PEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQKQF---SEILARSKWERDEA 861
E+ +V +L+ +++ TG +N + L K +A L Q E+L ++
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 862 QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
+ R+L+EE Q++L + E +Q ER + + +N + ++Q + + L+E
Sbjct: 1335 STKLRQLEEERNSLQDQL-DEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 922 NLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE---LK 977
K + EI+ LT ++ E A +LEK K + + V LD + +
Sbjct: 1393 GKKRFQKEIENLT--------QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 978 KLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLT 1037
L+K D+L E I+ K ER EA KA AR L
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISS-----------KYADERDRAEAEAREKETKALSLARALE 1493
Query: 1038 RA-EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQN 1096
A EA+ EL + K E L K VG + L ME +T++ L++
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 1097 VLDLTGSDN----------KGGFENVL----EEIAELRREVSYQ-NDYISSMADPFKRR 1140
L T KG FE L E+ E RR++ Q ++Y + + D K+R
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Score = 130 bits (328), Expect = 1e-29
Identities = 209/1018 (20%), Positives = 430/1018 (42%), Gaps = 176/1018 (17%)
Query: 247 LESLEGQPVTTQDRQEAFERFSLEEVERLERDL-EKKMIETEELKSKQTRFLEEIKNQDK 305
+++ E + T++RQ+ E L+E+E+ L E+K + E+L+++ + E + + +
Sbjct: 854 MQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 306 LNKSLKE--------EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
L +E EA L+++ E+ L + + + Q+ ++L +++ Q+L
Sbjct: 913 LAAKKQELEEILHEMEARLEEE--EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDE----SPYIGKSRYKRNMFATESYIIDSAQAVQI 413
K+ A+ A+I K DE K +R + + + A +
Sbjct: 971 LEKVTAE-----------AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 414 KKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSELHDEIEKAEQQIL 468
+K + +L+N H ++ + + E+K EK + S+ H++I + QI
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 469 RATEEFKQLEEAIQ----------------LKKISEAGKDL--LYKQLSGRLQLVNKLRQ 510
+ + EE +Q LKKI E + L + L NK +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 511 EALDLELQMEKQKQEI--------------AGKQKEIKDLQIAID-SLDSKDPKHSHMKA 555
+ DL ++E K E+ A +++E+ L+ A+D S + + M+
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEI------------------KDLEE 597
+ + ++L +Q+++ ++ LD+ + KE ++ K LE
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 598 QLTE--GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
Q+ E + + E + +L + LQ + ++ G +A+ + KL + +L +L +
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 656 ----VEQERDQLEIVAMDAENMRKELAELESALQEQHE-----------VNASLQQTQGD 700
+++E Q V+ + +E L+ L E+ E +N L ++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 701 LSAYEAELEA-------------RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
L + + +EA L + E ++LEK Q E L +L+ +
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 748 RQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDFQNHLNHVVDGL 803
RQ + N E+K+++ +L A+ K++ D+ + + + ++ + + L
Sbjct: 1440 RQLVSNL-------EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 804 VRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
EE +EL R K+ EM ++ S D +GK++ +L+K S+ ++ E + Q
Sbjct: 1493 ---EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQ 1547
Query: 863 VRERKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
+ E L++E+ ++ +L + + ER L+AR Q+E + +Q++ ++H
Sbjct: 1548 LEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQAR----DEQNEEKRRQLQRQLHEY 1601
Query: 920 QENLK-----------SMEEIQG-LTDLQLQ--EADEEKERILAQLRELEKKKK-----L 960
+ L+ + ++++G L DL+LQ A + +E + QLR+L+ + K L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 961 EDAK-SQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
EDA+ S++++F KE +K K++ +L A+ K ++ +E A L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 1020 -------QEAERFSRKAAQAARDLTRAEAEIELLQNLLR---QKGEQFRLEMEKTGVGTG 1069
E R + AQ +L + +E + + +R Q+ EQ E+
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL------AT 1775
Query: 1070 ANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQ 1126
S + E + +ERQ E+ ++L + S K + +IA+L +V +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Score = 129 bits (325), Expect = 3e-29
Identities = 214/961 (22%), Positives = 418/961 (43%), Gaps = 126/961 (13%)
Query: 247 LESLEGQPVTTQDRQEAF--ERFSLEE-VERLERDL---EKKMIETEELKSKQTRFLEEI 300
++ LE + + D+ ER LEE + L +L E+K +LK+K + E+
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 301 KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360
+ + K + ++E K+ E SD + + L+ + EL K+ E E + A +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE-ELQAALAR 1098
Query: 361 IDAKFEPLNYYPSEYAEID-KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD 419
+D + N + E++ D + R RN E D + ++ K E +
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK--AEKQKRDLGEELEALKTELE 1156
Query: 420 EQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSE---LHD-EIEKAEQQILRATEEF 474
+ L + T +L K E++++ + L E H+ ++++ Q+ +A EE
Sbjct: 1157 DTLDS--------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 475 -KQLEEAIQLKKISEAGKDLLYKQ---LSGRLQLVNKLRQEALDLELQMEKQKQEIAGK- 529
+QLE+ + K + K L K+ L+G L+++ + +QE + ++E Q QE+ K
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268
Query: 530 ---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL--DI--MNKQYQQLESRLDEIL 582
++ +L + L ++ + M + GK +L D+ ++ Q Q + L E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 583 SRIAKETEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIK------GQATQ 634
+ + +++ LEE+ Q +E + K++LE IS L L K +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 635 AQNECRK-LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
A E +K + E E L Q+ E D+LE +++EL +L L Q ++ ++
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLE---KTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 694 LQQTQ---GDLSAYEAELEARL-NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQ 749
L++ Q L A E + ++ + RD + +E+ K L + + AL+A+ E ER
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 750 ALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
N + KA+ E+ ++ + L+ L+ Q+++ + L + D L E+
Sbjct: 1506 ---NKMLKAEM-EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI------------LARSKWE 857
R++ + LK G E ++ + + + LQ+Q E LA + +
Sbjct: 1562 KLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Query: 858 RDEAQVRERKLQEEMAL--------QQEKLATGQEEFRQACERALEARMNF--DKRQHEA 907
+ E +++ +LQ + A+ Q KL ++F++ E A +R +++E
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE--------------EKERILAQLRE 953
+ + +E ++ LQE+L + E + DL+ +E E EK R+ A++ +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 954 LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD------------QL 1001
LE ++LE+ + + D+ K ++A S++LAT T K+ +L
Sbjct: 1741 LE--EELEEEQGNMEAMS-DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 1002 KS-LH-----------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELL 1046
+S LH T+ + + A+ ++ E+ +R+ A + L + + EI L
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEIARLQNVLDLTGSDN 1105
R+ EQ++ + EK G Q+ ++E+ E +R +LQ LD N
Sbjct: 1858 VEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 1106 K 1106
+
Sbjct: 1915 E 1915
Score = 129 bits (324), Expect = 3e-29
Identities = 221/1024 (21%), Positives = 443/1024 (43%), Gaps = 145/1024 (14%)
Query: 85 EALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLD 144
EA IKKL +D + ++ N LSK+ K ++ + +L+ NL + EK
Sbjct: 977 EAKIKKL--EDEILVMDDQNNKLSKE-----------RKLLEERISDLTTNLAEEEEKAK 1023
Query: 145 KLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNK 204
L KL+ N + IS++E L+K + E+E + L +
Sbjct: 1024 NLTKLK--NKHESMISELE-----VRLKKEEKSRQELEKLKRKLEGDASDFH------EQ 1070
Query: 205 ISSLQ-DISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
I+ LQ I++LK +Q ++ + L + L+ + LEG Q+ ++
Sbjct: 1071 IADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 264 FERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323
ER + + E+ +RDL + E E LK++ L+ Q +L ++E + K++ +E
Sbjct: 1130 -ERAARNKAEKQKRDLGE---ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 324 LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD 383
+ + ++QK + +Q E F + A + N E D A
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLE-----QFKRAKANLDK-NKQTLEKENADLA-G 1238
Query: 384 ESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE 443
E +G+++ Q V+ KK + L+ Q+++ +
Sbjct: 1239 ELRVLGQAK----------------QEVEHKKKK-----------------LEAQVQELQ 1265
Query: 444 KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE-EAIQLKK----ISEAGKD---LLY 495
K S + +EL+D++ K + ++ T + E +AI+L K +S +D LL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 496 KQLSGRLQLVNKLRQ---EALDLELQMEKQKQEIAGKQKEIKDLQIAI-DSLDSKDPKHS 551
++ +L + KLRQ E L+ Q++++ + ++ I L I + DS S
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 552 HMKAQKSGK---EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL-TEGQIAAN 607
++A + GK +++++ + +QY++ + D++ + +E+ DL L + Q+ +N
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 608 -EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI- 665
E ++ + +++ + + +A+ E R+ + +L + L E + +++LE
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 666 ----------VAMDAENMRKELAELES---ALQEQ-HEVNASLQQTQGDLSAYE-AELEA 710
+ +++ K + ELE AL+ Q E+ L++ + +L A E A+L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 711 RLNL--------RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE 762
+N+ RD +A + E ++ QL + + E E++++AL A K +
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 763 EKE---QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK 819
K+ Q +S + + + ++ L + Q+KDFQ L D +E+ A E +K
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKL-QAQMKDFQRELE---DARASRDEIFATAKENEKK 1681
Query: 820 LKLGTGEMNIHSPSDVLG----KSLADLQKQ-FSEILARSKWERDEAQVRERKLQEEMAL 874
K ++ + D+ + ADL+K+ +E LA S R+ Q +R+L+ +A
Sbjct: 1682 AKSLEADL-MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 875 QQEKLATGQEEFRQACERALEARMNFDK------------RQHEARIQQMENEIHYLQEN 922
+E+L Q +R +A ++ +++E+ QQ+E + L+
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 923 LKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKA 982
L ME G + + E +AQL E +++ E + + + DK+LK++
Sbjct: 1801 LHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 983 VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
V K+A K+Q + + V ++ ++ E +E++R + + R+L A
Sbjct: 1858 VEDERKMAEQY----KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 1043 IELL 1046
E +
Sbjct: 1914 NEAM 1917
Score = 103 bits (258), Expect = 2e-21
Identities = 139/642 (21%), Positives = 279/642 (43%), Gaps = 134/642 (20%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
S+L+D + L+ + R++ + RQ E+E L +D+ ++ K++LE + L+ +
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 1386 KRQQQKDFIDGNVESL-----MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL----- 1435
+++ VE+L + EIE + +E+ + +EKT + + EL
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 1436 ----------------READRLLAEAE------------SELSCTKEKTK-----NAVEK 1462
R+ D+LLAE + +E +++TK A+E+
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 1463 FTDAKRSLLQT----ESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI 1518
+AK L +T +++ E+L + N+ + ++ R+L+ +E+ K + EE+
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET---QMEEMKTQLEEL 1551
Query: 1519 LKEINKIVAAK--------------DSDFQCLSKKKEKLTEELQKL--QKDIEMAERNED 1562
E+ AK + D Q ++ E+ +LQ+ + + E+ + +
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 1563 HHLQVLKE-------SEVLLQAKRA---------ELEKLKSQVTSQQQEM----AVLDRQ 1602
L + ++ LQA A +L KL++Q+ Q+E+ A D
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1603 LGHKKE---ELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
KE + L+ ++Q + DL A R + EK + L EEL+
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-------EELAEELASSLSGR 1724
Query: 1660 NVQISERK---TQLTLIKQEIEKEEENLQVV---LRQMSKHKTELKNIL----------- 1702
N E++ ++ +++E+E+E+ N++ + +R+ ++ +L N L
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 1703 ---DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL-ELENLQQISQQQKGEIEWQK 1758
L+ +N EL+ + + V K+ +A LE K+ +LE +Q+ Q+ + + K
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE--EQVEQEAREKQAATK 1842
Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
L ++DK+ E + VE K E +E+ + ++ Q KR L AEE S
Sbjct: 1843 SLKQKDKKLKEILLQ--------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES- 1893
Query: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
+++ N RKLQ+ELD+ ++ +++A++ +L+
Sbjct: 1894 ------QRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 101 bits (251), Expect = 1e-20
Identities = 133/611 (21%), Positives = 268/611 (43%), Gaps = 70/611 (11%)
Query: 563 QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS 619
Q+ ++ Q E L + R K E+K+LE+ QLTE + E L+ + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE---- 901
Query: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQLEIVAMDAENMRKELA 678
+ +A + + + E E +L + +E+E D+ + + + + M +++
Sbjct: 902 --------LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQ 734
+LE L+E+ LQ + A +LE + + D + N+L +E E+++ LT
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 735 --LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQQLKD 791
E+ L K + ++ + + + +KE+++ + KLK L+ D + +Q+ D
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 792 FQNHLNHVVDGLVRPEE-----VAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
Q + + L + EE +A DE+ +K N L ++DLQ+
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQK-------NNALKKIRELEGHISDLQED 1126
Query: 847 F-SEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACER---ALEARMNF 900
SE AR+K E+ + + E L+ E+ + AT Q+E R E+ L+ ++
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE 1185
Query: 901 DKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
+ R HEA++Q+M + + L E L+ + + D Q ++E + +LR L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 957 KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA 1016
K+ + K ++ L+ ++++L+ + ++ A AEL D++ L V +
Sbjct: 1246 AKQEVEHKKKK----LEAQVQELQSKCSDGER-ARAEL---NDKVHKLQNEVESV----T 1293
Query: 1017 EELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE 1076
L EAE KA + A+D+ ++++ Q LL+++ Q K V T E
Sbjct: 1294 GMLNEAE---GKAIKLAKDVASLSSQLQDTQELLQEETRQ------KLNVSTKLRQLEEE 1344
Query: 1077 IEKLNETMERQ---RTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
L + ++ + + + R + L++ SD+K ++ + L I ++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 1134 ADPFKRRGYWY 1144
++ + Y
Sbjct: 1405 TQQYEEKAAAY 1415
Score = 97.4 bits (241), Expect = 1e-19
Identities = 129/622 (20%), Positives = 260/622 (41%), Gaps = 53/622 (8%)
Query: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
+++ L Q+++Q++ E++ ++ L++ K ++ E + L+ L++EK LQE+
Sbjct: 840 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
+ A+ + + + + L ++E + + + QL ++ + + +++Q
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
L+E+ A LQ E + + + ++L + L E+ L++ IS+
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL--- 1015
Query: 1919 QKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQKERESEE----------SKL 1964
EEE K + L L+N+ I E +++L ++E Q L+K + E + L
Sbjct: 1016 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEEERWCESLE 2017
+ LK Q + E+EL ++LD L K+ E + LQE+ +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 2018 KTLSQTKRQLSEREQQL---VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQV 2073
+ KR L E + L +E + + A Q+E + R + ++L+ E + E QV
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
+++ +L + L + K+ + + K T+E ++N + A L + L Q + E
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEV 1250
Query: 2134 TELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
KK++ Q D ER + E++D + L++EV + + L +L D
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKD 1309
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE 2245
+ ++ + L+ E L+E +N +L + + D+ ++ L
Sbjct: 1310 VASL---SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 2246 DRLKAQLRHCMSK------QAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASS 2298
L QL K E L +GK++ + + +L +Q + +
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 2299 PSLSQLESSLTEDSQLGQNQEK 2320
L L L QL N EK
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEK 1448
Score = 77.8 bits (190), Expect = 1e-13
Identities = 111/510 (21%), Positives = 221/510 (43%), Gaps = 68/510 (13%)
Query: 265 ERFSLEEVERLERDLEKKMIETEELKSKQT--RFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
+R + +E+ +R ++ + E + + SK R E + ++K K+L L++
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-- 1496
Query: 323 ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK--IDAKFEPLNYYPSEYAEIDK 380
E K +L N++LK + +L + + EL K ++ + E + E + +
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 381 APDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE 440
A +++ K R + NM A + QA + E QL+ R +T+LE
Sbjct: 1557 ATEDA----KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ------RQLHEYETELE 1606
Query: 441 DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLS 499
D+ K+ + A +L +++ E L+A K EEAI QL+K+ KD +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLE---LQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 500 GRLQL--------VNKLRQEALD---LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP 548
R N+ + ++L+ ++LQ + E A KQ +++ ++A + S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA-- 606
+++ ++ +K E ++ + ++ ++ + ++ + R+ K T++ + L +L + A
Sbjct: 1724 RNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 607 NEALKKDLEG----VISGLQEYLGTIKG----------------------QATQAQNECR 640
NE+ ++ LE + S L E G +K +A + Q +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 641 KLRDEKETLLQRLTEVEQERDQLEIVAMDAE----NMRKELAELESALQEQHEVNASLQQ 696
L+ + + L + L +VE ER E AE +++ +LE A +E +NA+ ++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 697 TQGDLSAYEAELEARLNLRDAEANQLKEEL 726
Q +L EA E N LK +L
Sbjct: 1903 LQRELDEATESNEA----MGREVNALKSKL 1928
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 174 bits (441), Expect = 9e-43
Identities = 223/1064 (20%), Positives = 472/1064 (44%), Gaps = 115/1064 (10%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + L+ ++ + A KR+ E E EL +IDDL +E E V+
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
++ +D + L E +K+L+ H+ +D+++ E TL K + +L ++ D
Sbjct: 977 NLTEEMAGLDEIIAKLTKE---KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD 1033
Query: 1441 LLA--EAESELSCTKEKTKNAVE---KFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
L E E ++ E+ K +E K T + S++ E+D ++L+ R ++ L +
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLT--QESIMDLENDKQQLDERLKKKDFELNALN 1091
Query: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
++ QA L++ + + ++E+ + + A+ + + K + L+ EL+++ + +E
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQ 1593
A +++ K+ E Q R +LE+ L Q+ + Q
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 1594 QEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
+ L+++ K EL + +M ++AKA+L++ R E ++ E + E + +
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 1651 ELSFQK-------GELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
+L+ Q+ GEL+ Q+ E++ +QLT K ++ E+L+ L + K K L +
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331
Query: 1701 ILDMLQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQK 1751
L Q H+ L+ Q++ QRV ++VA K E + +Q+ + ++
Sbjct: 1332 AL---QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1388
Query: 1752 GEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD-------IWEKKLA 1804
+ + ++L E ++ +E + A+ +L+ L E EDL + +KK
Sbjct: 1389 AKKKLAQRLQEAEEA-VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 1805 QTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKRE 1864
++LA ++ + QS LE + R L EL L N + L+ +
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL-------FKLKNAYEESLEHLETFKR 1500
Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
+LQEE++++ + L + + + K + L +E+ LQ + E E
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE---------AEASL 1551
Query: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV-----TLKEQQHQLE 1979
+ ++ ++L+ ++E N++K E+ + +K+ E E++K +V T + + +
Sbjct: 1552 EHEEGKILRAQLEFNQIKA---EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR 1608
Query: 1980 KELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
E K K++ L+++ + R E ++ +SL+ L T+ QL + + +
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668
Query: 2039 GELLALQKEADSMRADFSLLR---NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQK 2095
+ +++ + ++A+ LR Q RK AE+++ E +++ SQ + ++K
Sbjct: 1669 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK 1728
Query: 2096 QENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISD 2155
+ ++ + + +E Q+ + K + ELKK+ LER + +
Sbjct: 1729 KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788
Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGP 2215
++ L+ + + + +LK + L +L A R LE ELE+ ++ ++ +G
Sbjct: 1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEA-------RVRELENELEAEQKRNAESV-KGM 1840
Query: 2216 FEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 2275
+ + ++ E R LR L+ D+L+ +++ +QAE + + Q L
Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLR--LQDLVDKLQLKVK-AYKRQAE---EAEEQANTNLS 1894
Query: 2276 SLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQE 2319
R+ L E AD A S +++L + + G N+E
Sbjct: 1895 KFRKVQHELDE--AEERADIAES-QVNKLRAKSRDIGTKGLNEE 1935
Score = 152 bits (384), Expect = 4e-36
Identities = 225/1034 (21%), Positives = 451/1034 (43%), Gaps = 140/1034 (13%)
Query: 1398 VESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKRRSELREADRLLAEAESELSCTKEKT 1456
++ L+ E EK + ++ + E +EK+ RR EL E L + +++L +
Sbjct: 836 IKPLLKSAEREKEMASMKEEFTRLKEALEKSEA-RRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 1457 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
+ + DA+ Q + +LE + +E L ++ L A + LE + +
Sbjct: 895 Q---DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951
Query: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESE 1572
+ ++ +A + + K + LTEE+ L + I + ++ H Q L +
Sbjct: 952 RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD-- 1009
Query: 1573 VLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
LQA+ ++ L +Q++ L+ L +K+ ++ + +AK L+ L+L +
Sbjct: 1010 --LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK----VRMDLERAKRKLEGDLKLTQ 1063
Query: 1633 TEVTEKCNHIREVKSLLEELSFQKGELNVQI-------SERKTQLTLIKQEIEKEEENLQ 1685
+ + N +++ L++ F+ LN +I S+ + +L ++ IE+ EE L+
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 1686 V-------VLRQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSEL 1726
V + S EL+ I + L Q+E E + K++ D + L
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183
Query: 1727 EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS 1786
+ A K +++ ++ +Q ++ KQ LE++K E + E + S +E +
Sbjct: 1184 QHEATAAALRKKHADSVAELG-EQIDNLQRVKQKLEKEKSEFK---LELDDVTSNMEQII 1239
Query: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD------- 1839
K K +L++ C E ++ + + + + S KL+ +L ++LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299
Query: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
QL R KL+ + +++QL+E+ +A N+L L + + +L ++ T+ + L
Sbjct: 1300 QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR 1359
Query: 1900 EQTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQ 1951
++ ++++W ++E Q+ EE ++ Q+LQ + +E K E
Sbjct: 1360 VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419
Query: 1952 RLQKERESEESKLETSK---VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE 2008
RLQ E E +E S L ++Q +K L + K K ++ S++ ++++ R+L
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 2009 E-----ERWCESLE--KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
E + ESLE +T + + L E L E+ G E + +R + +
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 2062 FLTERKKAEKQVASLK-EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA- 2119
+ ++AE ASL+ E KI R+QLE N ++ + E +K+ + A+ NH R
Sbjct: 1540 LQSALEEAE---ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ--AKRNHLRVV 1594
Query: 2120 ---------------------RRLMKELNQMQYEYT-------ELKKQMAN-QKDLERRQ 2150
+++ +LN+M+ + + E +KQ+ + Q L+ Q
Sbjct: 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654
Query: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE- 2205
+++ DA+R ++K+ I + N EL +L A++E+ E E EL E
Sbjct: 1655 IQLDDAVRA-NDDLKENIAIVERRNNLLQAEL-EELRAVVEQTERSRKLAEQELIETSER 1712
Query: 2206 -NLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRH 2254
L + N +K + SQ+ E EA++E R+ E++ K A +
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVE----EAVQE-CRNAEEKAKKAITDAAMMAE 1767
Query: 2255 CMSKQAEV---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE- 2310
+ K+ + L + K+ E T+ L+ ++D ++ A L +LE+ + E
Sbjct: 1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI-----ALKGGKKQLQKLEARVREL 1822
Query: 2311 DSQLGQNQEKNASA 2324
+++L Q++NA +
Sbjct: 1823 ENELEAEQKRNAES 1836
Score = 124 bits (311), Expect = 1e-27
Identities = 180/802 (22%), Positives = 350/802 (43%), Gaps = 93/802 (11%)
Query: 1542 KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
K+ L+ +++ EMA E+ LKE+ +A+R ELE+ ++ S QE L
Sbjct: 835 KIKPLLKSAEREKEMASMKEE--FTRLKEALEKSEARRKELEE---KMVSLLQEKNDLQL 889
Query: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNV 1661
Q+ +++ L + Q ++ ++L E +V E + + + + EL+ +K +L
Sbjct: 890 QVQAEQDNLADAEERCDQL---IKNKIQL-EAKVKEMNERLEDEEEMNAELTAKKRKLED 945
Query: 1662 QISERKTQ---LTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQ 1718
+ SE K L L ++EKE+ + ++ +++ L I+ L E LQ
Sbjct: 946 ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA--- 1002
Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQL---LERDKREIERMTAES 1775
H Q + +L+ + V L+Q +G +E +K++ LER KR++E +
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE---GDL 1059
Query: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME---QSNLEKLELNVR 1832
+ Q + L +K+ L E+ +KK + + A E+ + Q L++L+ +
Sbjct: 1060 KLTQESIMDLENDKQQLDERL---KKKDFELNALNARIEDEQALGSQLQKKLKELQARIE 1116
Query: 1833 KLQQEL--DQLNRDKL-SLHNDISAMQQQLQEKRE---AVNSLQEELANVQD-HLNLAKQ 1885
+L++EL ++ R K+ L +D+S +++ E+ E S+Q E+ ++ ++
Sbjct: 1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 1886 DLLHTT-KHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLV 1944
DL T +H+ + + + ++E + ++ Q+ + Q L+ E E KL+L
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK-------QKLEKEKSEFKLELD 1229
Query: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK------ELTDQKSKLDQVLSKVLA 1998
+++ K + + E T + + E + + E+ +LT Q++KL
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ------TE 1283
Query: 1999 AEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLL 2058
E R L E+E L + +QL + ++QL E+ AL S R D LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 2059 RNQFLTERK-KAEKQVASLKEALKIQ--RSQLEKNLLEQKQENSCIQKEMA----TIELV 2111
R Q+ E + KAE Q K ++ R++ E + +++ +E +K++A E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 2112 AQDNHERARRLMKELNQMQYEYTEL---------------KKQMANQKDLERRQMEISDA 2156
+ + + L K +++Q E +L KKQ K L + + ++
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Query: 2157 MRTLKSEVKD--EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT---- 2210
L+S K+ + T L L E LE N+NL+ E+ L E L +
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 2211 ---------MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAE 2261
+ E + + EH G+ LR +L +++KA++ ++++ E
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF--NQIKAEIERKLAEKDE 1581
Query: 2262 VLIKGKRQTEGTLHSLRRQVDA 2283
+ + KR + SL+ +DA
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDA 1603
Score = 113 bits (282), Expect = 2e-24
Identities = 196/954 (20%), Positives = 396/954 (41%), Gaps = 147/954 (15%)
Query: 271 EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNT 330
+++ LE L K E ++K EE+ D++ L +E +++ ++ DL
Sbjct: 953 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012
Query: 331 KNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK 390
+ + K LT+A + +LEQ+ +D L ++++A K
Sbjct: 1013 EED----KVNTLTKA---KVKLEQQ-----VDDLEGSLEQEKKVRMDLERA--------K 1052
Query: 391 SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
+ + ++ T+ I+D ++ K + DE+L+ L L+ ++ED++ S Q
Sbjct: 1053 RKLEGDLKLTQESIMD----LENDKQQLDERLKKKDFELNA---LNARIEDEQALGSQLQ 1105
Query: 451 TRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQ 510
+L EL IE +LEE ++ ++ + A + L LS L+ +++ +
Sbjct: 1106 KKLKELQARIE--------------ELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 511 EALD-LELQMEKQKQEIAGKQKEIKDLQIA---------------IDSLDSKDPKHSHMK 554
EA +Q+E K+ A QK +DL+ A DS+ + +++
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 555 AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALK--K 612
K E++ + + S +++I+ A + + LE+Q+ E + A E +
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 613 DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA-- 670
DL + LQ G + Q + + +L K T Q+L +++++ ++ E+ A +A
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE-EVKAKNALA 1330
Query: 671 ---ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE 727
++ R + L +E+ E A LQ+ LS +E+ + +A Q EELE
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 728 KV-TRLTQLEQSALQA---------ELEKERQALKN-----------------ALGK--- 757
+ +L Q Q A +A LEK + L+N AL K
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 758 ------AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA 811
A++ ++ E+ SEL + K + + L + ++ L H+ + +
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1507
Query: 812 RVDELRRKLKLGTGEMNIHSPSDV---LGKSLADLQKQFSEILARSKWERDEAQVRERKL 868
+ +L +LG+ IH V L +LQ E A + E +E ++ +L
Sbjct: 1508 EISDLTE--QLGSSGKTIHELEKVRKQLEAEKMELQSALEE--AEASLEHEEGKILRAQL 1563
Query: 869 Q--EEMALQQEKLATGQEEFRQACERAL------------EARMNFD----KRQHEARIQ 910
+ + A + KLA EE QA L E R + K++ E +
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623
Query: 911 QMENEIHY-------LQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDA 963
+ME ++ + Q+ +KS++ + T +QL +A + + + +E++ L A
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 964 KSQE--QVFGLDKELKKL--KKAVATSDK--LATAELTIAKDQLKSLHGTVMKINQERAE 1017
+ +E V + +KL ++ + TS++ L ++ T +Q K + + ++ E E
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEE 1743
Query: 1018 ELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG---ANSQV 1074
+QE KA +A D E++ Q+ E+ + ME+T ++
Sbjct: 1744 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNMEQTIKDLQHRLDEAEQ 1802
Query: 1075 LEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQND 1128
+ ++ + +++ + L+N L+ N + + + + +E++YQ +
Sbjct: 1803 IALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTE 1855
Score = 112 bits (281), Expect = 3e-24
Identities = 185/874 (21%), Positives = 372/874 (42%), Gaps = 122/874 (13%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
EE RL+ LEK +EL+ K L+E KN +L +++ + ++ C++L
Sbjct: 854 EEFTRLKEALEKSEARRKELEEKMVSLLQE-KNDLQLQVQAEQDNLADAEERCDQL---- 908
Query: 329 NTKNEL-LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
KN++ L+ K E+ + + E+ EL K K E E +E+ + D+
Sbjct: 909 -IKNKIQLEAKVKEMNERLEDEEEMNAELTAKK--RKLE------DECSELKRDIDDLE- 958
Query: 388 IGKSRYKRNMFATESYIIDSAQAVQ-----IKKMEPDEQ-LRNDHMNLRGHTPLDTQLED 441
+ ++ ++ ATE+ + + + + I K+ +++ L+ H + ED
Sbjct: 959 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE---ED 1015
Query: 442 KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLS 499
K ++ A+ +L + D++E + +Q + + ++ + ++ LK E+ DL +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL----EN 1071
Query: 500 GRLQLVNKLRQEALDLE-LQMEKQKQEIAGK--QKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
+ QL +L+++ +L L + ++ G QK++K+LQ I+ L+ + ++A+
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEE------LEAE 1125
Query: 557 KSGK---EQQLDIMNKQYQQLESRLDEI-----------LSRIAKETEEIKDLEEQLTEG 602
++ + E+ ++++ +++ RL+E R A+ + +DLEE +
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
+ A KK + V + Q Q +KL EK L +V +Q
Sbjct: 1186 EATAAALRKKHADSV--------AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1237
Query: 663 LEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA-------ELEARLNLR 715
+ N+ K LE + E Q++ DL++ A EL +L+ +
Sbjct: 1238 ---IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294
Query: 716 DAEANQLKEELEKVTRLTQLEQSALQAELE-KERQALKNALGKAQFS----EEKEQENSE 770
+A +QL K+T QLE Q E E K + AL +AL A+ E+ +E +E
Sbjct: 1295 EALISQLTR--GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 771 LHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN-I 829
A+L+ + L K + Q + D + R EE+ +L ++L+ + +
Sbjct: 1353 AKAELQRV-----LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 830 HSPSDVLGKSLADLQKQFSEILA---RSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
++ L K+ LQ + +++ RS ++R + +A ++K Q E
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467
Query: 887 R--QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944
Q R+L + K +E ++ +E + +EN EEI LT+ QL + +
Sbjct: 1468 ESSQKEARSLSTELFKLKNAYEESLEHLET---FKRENKNLQEEISDLTE-QLGSSGK-- 1521
Query: 945 ERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004
+ ELEK +K +A+ E L++ L+ K+ A+L + +
Sbjct: 1522 -----TIHELEKVRKQLEAEKMELQSALEEAEASLEH---EEGKILRAQL-----EFNQI 1568
Query: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064
+ + E+ EE+++A+R + + + AE R + E R++ +
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET---------RSRNEALRVKKKME 1619
Query: 1065 GVGTGANSQVLEIEKLNETMERQRTEIARLQNVL 1098
G N +++ N + ++ LQ++L
Sbjct: 1620 G---DLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650
Score = 110 bits (276), Expect = 1e-23
Identities = 151/726 (20%), Positives = 316/726 (43%), Gaps = 70/726 (9%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
NLE LED M +SK EE +++DL ++ L+ E E
Sbjct: 1244 NLEKMCRTLEDQMNEHRSK-----------------AEETQRSVNDLTSQRAKLQTENGE 1286
Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHH-EDIVDEIECIEKTLLKRRSE---L 1435
L R + +++ I +T + + LK E+ V + L R + L
Sbjct: 1287 LSRQLDEKEA---LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTES--DAEELERRAQETAVNLVK 1493
RE EA++EL K + V ++ R+ +T++ EELE ++ A L +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQW----RTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
A++ + ++ A LE+ K + + ++++ V ++ L KK+ + L + ++
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 1554 IEMAERN-EDHHLQVLKESEVLLQAKRA------ELEKLKSQVTSQQQEMAVLDRQLGHK 1606
E ++ E + S L + K A LE K + + Q+E++ L QLG
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSS 1519
Query: 1607 KEELHLLQGSMVQAKA---DLQEALRLGETEVTEKCNHIREVKSLLEELSFQ--KGELNV 1661
+ +H L+ Q +A +LQ AL E + + E K L +L F K E+
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE-----EGKILRAQLEFNQIKAEIER 1574
Query: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQ 1721
+++E+ ++ K+ + ++LQ L ++ + E + ++ + +E++ ++L H
Sbjct: 1575 KLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME-IQLSHAN 1633
Query: 1722 RVSELEKTQVAVLEEKLELENLQ-QISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
R++ + QV L+ L+ +Q + + +++ ++ER ++ E RA+
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
E K E QE + E+ + + + KM+ ++L +L+ V + QE
Sbjct: 1694 QTERSRKLAE--QELIETSERVQLLHSQNTSLINQKKKMD-ADLSQLQTEVEEAVQECRN 1750
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREA-------VNSLQEELANVQDHLNLAKQDLLHTTKH 1893
D + M ++L+++++ ++++ + ++Q L+ A+Q L K
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 1894 QDVLLSEQTR-LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR 1952
Q L + R L+ ++ R + K +++++ L + EE++ L++ + + +
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Query: 1953 LQ-------KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005
LQ ++ E E + T+ ++ QH+L+ E ++ + ++K+ A + T
Sbjct: 1871 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD-EAEERADIAESQVNKLRAKSRDIGT 1929
Query: 2006 --LQEE 2009
L EE
Sbjct: 1930 KGLNEE 1935
Score = 80.9 bits (198), Expect = 1e-14
Identities = 125/608 (20%), Positives = 258/608 (42%), Gaps = 100/608 (16%)
Query: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGL 621
+ + N + +L ++ +L +E +E+ ++E+ T + + +EA +K+LE + L
Sbjct: 822 MGVKNWPWMKLYFKIKPLLKSAERE-KEMASMKEEFTRLKEALEKSEARRKELEEKMVSL 880
Query: 622 QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
+ ++ Q Q+ + + L++ ++E + ++ D E M EL +
Sbjct: 881 LQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Query: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ 741
L+++ + L++ DL A++E + + + L EE+ + +
Sbjct: 941 RKLEDEC---SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII-------- 989
Query: 742 AELEKERQALKNALGKA--QFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
A+L KE++AL+ A +A E+++ N+ AK+K L+QQ+ D + L
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK--------LEQQVDDLEGSLE-- 1039
Query: 800 VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
+E R+D R K KL G++ + +S+ DL E D
Sbjct: 1040 -------QEKKVRMDLERAKRKL-EGDLKLTQ------ESIMDL-------------END 1072
Query: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI--- 916
+ Q+ ER +++ L R E+AL +++ ++ +ARI+++E E+
Sbjct: 1073 KQQLDERLKKKDFELNALNA-------RIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 917 ---------------HYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK----- 956
L+E + +EE G T +Q++ + + R+LE+
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 957 -------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGT 1007
+KK D+ ++ EQ+ L + +KL+K + KL ++T +Q+
Sbjct: 1186 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 1008 VMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQ-NLLRQKGEQFRLEMEKTGV 1066
+ K+ + +++ E + + ++ DLT A+++ L RQ E+ L + T
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT-- 1302
Query: 1067 GTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFENVLEEIAELRREV 1123
G + ++E L +E + L + L D + +E E AEL+R +
Sbjct: 1303 -RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Query: 1124 SYQNDYIS 1131
S N ++
Sbjct: 1362 SKANSEVA 1369
Score = 79.0 bits (193), Expect = 5e-14
Identities = 152/745 (20%), Positives = 314/745 (42%), Gaps = 93/745 (12%)
Query: 126 KLEVLNLSYNLIGKIE---KLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIE 182
KLE+ +++ N+ I+ L+K+ + E ++ ++ SK E + N A + E
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTE 1283
Query: 183 HIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIF 242
+ + K + L K++ Q + LK + L + +N L H LQ
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLK--RQLEEEVKAKN---ALAHALQSARH 1338
Query: 243 HLRSL-ESLEGQPVTTQDRQEAFERFSLEEVE---RLERDLEKKMIETEELKSKQTRFLE 298
L E E + + Q + + E + + E D ++ E EE K K + L+
Sbjct: 1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Query: 299 EIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAF 358
E + E + S E+ K L + E L +E + A + +Q F
Sbjct: 1399 EAEEA-------VEAVNAKCSSLEKTKHRLQNEIEDL-MVDVERSNAAAAALDKKQR-NF 1449
Query: 359 YKIDAKFEPLNYYPSEYAEIDKAPDESPYIG------KSRYKRNMFATESYIIDSAQAVQ 412
KI A+++ Y +E++ + E+ + K+ Y+ ++ E++ ++ +Q
Sbjct: 1450 DKILAEWK--QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN-LQ 1506
Query: 413 IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE 472
+ + EQL + + + QLE ++ ++ +A L E +E E +ILRA
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA---LEEAEASLEHEEGKILRAQL 1563
Query: 473 EFKQLEEAIQLKKISEAGKDL---------LYKQLSGRLQLVNKLRQEAL---------- 513
EF Q++ I+ +K++E +++ + L L + R EAL
Sbjct: 1564 EFNQIKAEIE-RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622
Query: 514 -DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQ 572
++E+Q+ + A QK++K LQ + D++ ++A KE + I+ ++
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLK--DTQIQLDDAVRANDDLKEN-IAIVERRNN 1679
Query: 573 QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 632
L++ L+E L + ++TE + L EQ + E + + Q
Sbjct: 1680 LLQAELEE-LRAVVEQTERSRKLAEQ------------------ELIETSERVQLLHSQN 1720
Query: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
T N+ +K+ + L Q TEVE+ + A+ + A + L+++ + +A
Sbjct: 1721 TSLINQKKKMDAD---LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA 1777
Query: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQL-----KEELEKVTRLTQLEQSALQAELEKE 747
L++ + ++ +L+ RL+ EA Q+ K++L+K+ + ++ L+AE ++
Sbjct: 1778 HLERMKKNMEQTIKDLQHRLD----EAEQIALKGGKKQLQKLEARVRELENELEAEQKRN 1833
Query: 748 RQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD----GL 803
+++K + +E + E L LQD + L+ ++K ++ + L
Sbjct: 1834 AESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1893
Query: 804 VRPEEVAARVDELRRKLKLGTGEMN 828
+ +V +DE + + ++N
Sbjct: 1894 SKFRKVQHELDEAEERADIAESQVN 1918
Score = 65.9 bits (159), Expect = 5e-10
Identities = 121/516 (23%), Positives = 225/516 (43%), Gaps = 88/516 (17%)
Query: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
S E+E +++ E +LK+ LE ++ + NK+L+EE E+L S
Sbjct: 1463 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI---SDLTEQLGSS 1519
Query: 328 LNTKNEL------LKQKTIELTRACQK-----QYE----LEQELAFYKIDAKFEPLNYYP 372
T +EL L+ + +EL A ++ ++E L +L F +I A+ E
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE------ 1573
Query: 373 SEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH 432
+ AE D+ +++ KRN ++DS Q D + R+ + LR
Sbjct: 1574 RKLAEKDEEMEQA--------KRNHLR----VVDSLQT------SLDAETRSRNEALRVK 1615
Query: 433 TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ----LKK--- 485
++ L + E ++S A +E ++ K+ Q +L+ T+ QL++A++ LK+
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQV-KSLQSLLKDTQ--IQLDDAVRANDDLKENIA 1672
Query: 486 ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS 545
I E +LL +L +LR E + +QE+ + ++ L SL +
Sbjct: 1673 IVERRNNLLQAEL-------EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1725
Query: 546 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIA 605
+ K M A S + +++ ++ + E + + ++ A EE+K +EQ T +
Sbjct: 1726 QKKK---MDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK--KEQDTSAHL- 1779
Query: 606 ANEALKKDLEGVISGLQEYLG-----TIKGQATQAQN---ECRKLRDEKETLLQRLTE-- 655
E +KK++E I LQ L +KG Q Q R+L +E E +R E
Sbjct: 1780 --ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Query: 656 --VEQERDQLEIVAMDAENMRKELAELESALQE-QHEVNASLQQTQGDLSAYEAELEARL 712
+ + +++ + E RK L L+ + + Q +V A +Q A EAE +A
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ------AEEAEEQANT 1891
Query: 713 NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER 748
NL ++ +++ EL++ + +S + K R
Sbjct: 1892 NL--SKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 173 bits (439), Expect = 2e-42
Identities = 222/1020 (21%), Positives = 447/1020 (43%), Gaps = 135/1020 (13%)
Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS 1410
++EKEM + + + +E E +EL + Q+K+ + +L+++
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDL---------QLQVQSE 898
Query: 1411 LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
++ D + E + K+ + ++++E L E E S K +N +K + KR +
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 1471 LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
E ++E+ T + +++ +L+ + L + K +E ++ + ++
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 1531 SDFQCLSK---KKEKLTEELQ-------KLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
L K K E+ T++L+ KL+ D+E A+R + L++ +ES + L+ +
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 1581 EL-EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC 1639
++ EKLK + Q A +D E++H LQ + ++ E
Sbjct: 1079 QIEEKLKKKEFELSQLQAKID------DEQVHSLQ----------------FQKKIKELQ 1116
Query: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
I E++ +E + ++ Q S+ +L I + +E+ + K + E +
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 1700 NILDMLQLENHELQGLKLQHDQRVSELEKTQV-AVLEEKLELENLQQISQQQKGEIEWQK 1758
+ LE LQ H+ + L K Q +V E +++NLQ++ K
Sbjct: 1177 KM--RRDLEEATLQ-----HEATAATLRKKQADSVAELGEQIDNLQRV-----------K 1218
Query: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKC--------DIWEKKLAQTKRVL 1810
Q LE++K E++ E + S +E LSK K +++ C +I K QT+ +
Sbjct: 1219 QKLEKEKSELK---MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 1811 AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQ 1870
+ ++++ N E L V + + + QL + K +L + +++Q++E+ +A N++
Sbjct: 1276 DLNMQKARLQTQNGE-LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334
Query: 1871 EELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED--CQKEEETKQ-- 1926
L + + +L ++ + + L ++ ++++W ++E Q+ EE ++
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 1927 ----QQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE---TSKVTLKEQQHQLE 1979
Q+LQ + E K E QRLQ E E LE T+ TL ++Q +
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFD 1454
Query: 1980 KELTDQKSKLDQVLSKVLAAEERVRTLQEE--------ERWCESLEKTLSQTKRQLSERE 2031
K L + K KLD+ +++ AA++ R+L E E + LE TL + + L E
Sbjct: 1455 KVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLE-TLRRENKNLQEEI 1513
Query: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA------SLK-EALKIQR 2084
L E+ E +EA+ + + L E++K++ QVA SL+ E KI R
Sbjct: 1514 SDLTEQIAETGKNLQEAE---------KTKKLVEQEKSDLQVALEEVEGSLEHEESKILR 1564
Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELN---QMQYEYTELKKQM- 2140
QLE + ++ + + I+K+ IE + +++ A L L+ + + + LKK+M
Sbjct: 1565 VQLELSQVKSELDRKVIEKD-EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
Query: 2141 --ANQKDLE-----RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERN 2193
N+ +++ R+ E +RT++ ++KD + L + + +L L + RN
Sbjct: 1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS-QLHLDDALRSNEDLKEQLAIVERRN 1682
Query: 2194 ENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK---LRHREDRLKA 2250
L ELE +K L T E S+ ++D R + L + L + + +L+A
Sbjct: 1683 GLLLEELEEMKVALEQT------ERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEA 1736
Query: 2251 QLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE 2310
+ C + + E I+ R E ++ + + + +S L +++ +L +
Sbjct: 1737 DIAQCQA-EVENSIQESRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792
Score = 167 bits (423), Expect = 1e-40
Identities = 220/1057 (20%), Positives = 460/1057 (43%), Gaps = 147/1057 (13%)
Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQ-------KDFIDGNVESLMT 1403
+SE +EL + LLQEK L+ +V+ + +++ K ++ V+ L
Sbjct: 869 RSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTE 928
Query: 1404 ELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKF 1463
LE E+ + + ++V + +E + ++ + + L + E E T+ K KN E+
Sbjct: 929 RLEEEEEM--NSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEM 986
Query: 1464 TDAKRSLLQTESDAEELERRAQETAVNL--------------VKADQQLRSLQADAK--- 1506
T + ++ + + + L+ Q+T +L K +QQ L+ +
Sbjct: 987 TALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK 1046
Query: 1507 ----DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
DLE+ K K E LK + + ++D Q + +K +K EL +LQ I+ +
Sbjct: 1047 KLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID---DEQV 1103
Query: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
H LQ K+ + L +A +E+L+ ++ ++ A +++Q EL + + +A
Sbjct: 1104 HSLQFQKKIKEL----QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASG 1159
Query: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQ-----------KGELNVQISERKTQLT 1671
+ + + E ++++ LEE + Q + + ++ E+ L
Sbjct: 1160 ATSAQIEMNKKREAE----FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 1672 LIKQEIEKEEENLQVVLRQM-------SKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
+KQ++EKE+ L++ + M SK K+ ++ ++ + E++ Q Q +
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER-MTAESRALQSCVE 1783
+L + + + EL + + + ++ KQ L + E++R M E++A +
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335
Query: 1784 CLSKEKED---LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
L + D L+E+ + ++ A+ +R L+ A NS++ Q K E + + +EL++
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRALSKA--NSEVAQWRT-KYETDAIQRTEELEE 1392
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV---- 1896
+ ++ Q+ +E E NS L + L +DL+ +
Sbjct: 1393 AKKK-------LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445
Query: 1897 LLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
L +Q K ++EW + ++ Q E E Q++ + L E+ K++ +E++ Q
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL--FKMRNAYEEVVDQLETLR 1503
Query: 1957 RESEESKLETSKVTLKEQQHQLEKELTD---QKSKLDQVLSKVLAAEERVR-TLQEEERW 2012
RE++ + E S +T EQ + K L + K ++Q S + A E V +L+ EE
Sbjct: 1504 RENKNLQEEISDLT--EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 2013 CESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSL---------LRNQFL 2063
++ LSQ K SE +++++EK E+ L++ +S RA +L RN L
Sbjct: 1562 ILRVQLELSQVK---SELDRKVIEKDEEIEQLKR--NSQRAAEALQSVLDAEIRSRNDAL 1616
Query: 2064 TERKKAE--------------KQVASLKEALKIQRSQLEKNLL---EQKQENSCIQKEMA 2106
+KK E +Q+A ++ L+ + QL+ + L + + N +++++A
Sbjct: 1617 RLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676
Query: 2107 TIELVAQDNHERARRLMKELNQMQ--YEYTELKKQMANQKDLERRQMEISDAMRTLKSEV 2164
+E R L++EL +M+ E TE ++++ E+ ++ SD ++ L S+
Sbjct: 1677 IVE-------RRNGLLLEELEEMKVALEQTERTRRLS-----EQELLDASDRVQLLHSQN 1724
Query: 2165 KDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQ 2224
I T K L + + A++E ++ + N E E K+ + +K +
Sbjct: 1725 TSLINTK-KKLEADIAQCQAEVENSIQESRNAE---EKAKKAITDAAMMAEELKKEQDTS 1780
Query: 2225 VHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDAL 2284
H+ E+++ ++ L+H + + ++ +KG ++ L + R+++
Sbjct: 1781 AHL-----------ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE-- 1827
Query: 2285 GELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
EL + + + E + E + + KN
Sbjct: 1828 NELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKN 1864
Score = 115 bits (288), Expect = 5e-25
Identities = 187/969 (19%), Positives = 409/969 (42%), Gaps = 110/969 (11%)
Query: 244 LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMI---------------ETEE 288
L+S E+ + +D + E + E R ++LE+KM+ ETE
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARR--KELEEKMVSLLQEKNDLQLQVQSETEN 901
Query: 289 LKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQK 348
L + R IK++ L +KE ++ EE+ S+L K L+ K L R
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEE-EEMNSELVAKKRNLEDKCSSLKRDID- 959
Query: 349 QYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK-SRYKRNMFATESYIIDS 407
+ EL K++ + +E A +E+ I K ++ K+++ +D
Sbjct: 960 ----DLELTLTKVEKEKHATENKVKNLSEEMTALEEN--ISKLTKEKKSLQEAHQQTLDD 1013
Query: 408 AQAVQIK-----KMEPDEQLRNDHM--NLRGHTPLDTQLEDKEKKISA----AQTRLSEL 456
Q + K K+ + + D + +L L LE ++K+ +Q + +L
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDL 1073
Query: 457 HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLE 516
++ ++ E+++ + E QL+ I +++ K+L R++ + + + L
Sbjct: 1074 ENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133
Query: 517 LQMEKQKQEIAGKQKEIKD-LQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLE 575
++EKQ+ ++A + +EI + L+ A + ++ + +A+ + L+ Q++
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193
Query: 576 SRLDEILSRIAKETEEIKDLEEQLTEGQIAAN--EALKKDLEGVISGLQEYLGTIKGQAT 633
+ L + K+ + + +L EQ+ Q E K +L+ I + + + +
Sbjct: 1194 ATLRK------KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 634 QAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNAS 693
+ CR + D+ + + EQ+ + + M ++ + EL ++E+ + +
Sbjct: 1248 NIERTCRTVEDQFSEI---KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ 1304
Query: 694 LQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQA--- 750
L +++ L+ EL+ ++ E + K + + ++ + L+ + E+E++A
Sbjct: 1305 LTKSKQALTQQLEELKRQME----EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 751 LKNALGKA--QFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEE 808
L+ AL KA + ++ + + ++ + + L++ L Q+L++ + + E+
Sbjct: 1361 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420
Query: 809 VAAR----VDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
R V++L R L+ H+ L K Q+ F ++LA K + DE+Q
Sbjct: 1421 TKQRLQGEVEDLMRDLE------RSHTACATLDKK----QRNFDKVLAEWKQKLDESQAE 1470
Query: 865 ERKLQEEMALQQEKLATGQEEFRQACERALE--ARMNFDKRQHEARIQQMENEIHYLQEN 922
Q+E L+T + R A E ++ + + + + I + +I +N
Sbjct: 1471 LEAAQKE----SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKN 1526
Query: 923 LKSMEEIQGLTDLQ---LQEADEEKERIL--AQLRELEKKKKLEDAKSQ--EQVFGLDKE 975
L+ E+ + L + + LQ A EE E L + + L + +L KS+ +V D+E
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586
Query: 976 LKKLK----KAVATSDKLATAELTIAKDQL---KSLHGTVMKI-------NQERAE---- 1017
+++LK +A + AE+ D L K + G + ++ N++ AE
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646
Query: 1018 ------ELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGAN 1071
+L++++ A ++ DL A +E LL ++ E+ ++ +E+T +
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 1072 SQ-VLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYI 1130
Q +L+ + + Q T + + L+ + + EN ++E +
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766
Query: 1131 SSMADPFKR 1139
+ MA+ K+
Sbjct: 1767 AMMAEELKK 1775
Score = 115 bits (287), Expect = 7e-25
Identities = 197/931 (21%), Positives = 396/931 (42%), Gaps = 89/931 (9%)
Query: 161 KIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLK--GNKISSLQDISKLKPLQ 218
K+EG M ++L N+ + I L KK L L K ++ SLQ K+K LQ
Sbjct: 1058 KLEGDLKMSQESIMDLE-NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 219 DLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLE-------- 270
I + E + H L+ I RS + E + ++ + +EA S +
Sbjct: 1117 ARIEELEEE---IEAEHTLRAKIEKQRSDLARELEEISER-LEEASGATSAQIEMNKKRE 1172
Query: 271 -EVERLERDLEKKMIETEE----LKSKQTRFL----EEIKNQDKLNKSLKEEAMLQKQSC 321
E +++ RDLE+ ++ E L+ KQ + E+I N ++ + L++E K
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232
Query: 322 EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKA 381
+++ S++ E L + + R C+ + E+ K + + + ++ + A +
Sbjct: 1233 DDMASNI----EALSKSKSNIERTCRTVEDQFSEIKA-KDEQQTQLIHDLNMQKARLQTQ 1287
Query: 382 PDESPYIGKSRYKRNMFATESYIIDSAQAVQIKK-MEPDEQLRNDHMNLRGHTPLDTQLE 440
E + + + T+S + Q ++K+ ME + + +N + + D L
Sbjct: 1288 NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL- 1346
Query: 441 DKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSG 500
++ Q +EL + KA ++ + +++ +AIQ + E K K+L+
Sbjct: 1347 -LREQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAK----KKLAQ 1399
Query: 501 RLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK 560
RLQ + + A +EK KQ + G E++DL +D + SH K
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQG---EVEDLM--------RDLERSHTACATLDK 1448
Query: 561 EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISG 620
+Q+ +K + + +LDE + + +E + L +L + + A E +
Sbjct: 1449 KQRN--FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV---------- 1496
Query: 621 LQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAEL 680
+ L T++ + Q E L ++ + L E E+ + ++V + +++ L E+
Sbjct: 1497 --DQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK---KLVEQEKSDLQVALEEV 1551
Query: 681 ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSAL 740
E +L+ + + + + Q +LS ++EL+ ++ +D E QLK + R + QS L
Sbjct: 1552 EGSLEHEE---SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ---RAAEALQSVL 1605
Query: 741 QAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL--LKQQLKDFQNHLNH 798
AE+ AL+ L K + E E H+ + + +L ++ QLKD Q HL+
Sbjct: 1606 DAEIRSRNDALR--LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663
Query: 799 VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
+ +E A V+ L EM + + L++ + + + +
Sbjct: 1664 ALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQ 1723
Query: 859 DEAQVR-ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ-----M 912
+ + + ++KL+ ++A Q ++ +E R A E+A +A + E + +Q +
Sbjct: 1724 NTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783
Query: 913 ENEIHYLQENLKSMEE-IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFG 971
E L++ +K ++ + L L+ ++ +++ ++RELE + +E + E + G
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843
Query: 972 LDKELKKLKKAV--ATSDKLATAELTIAKDQL----KSLHGTVMKINQERAEELQEAERF 1025
K +K+K+ A D L D+L KS + ++ +L R
Sbjct: 1844 AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903
Query: 1026 SRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
+ +AA AE+++ L+ R G Q
Sbjct: 1904 QHELEEAAERADIAESQVNKLRAKSRDVGSQ 1934
Score = 106 bits (264), Expect = 3e-22
Identities = 118/606 (19%), Positives = 252/606 (41%), Gaps = 59/606 (9%)
Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
C++ E + ++ E +Q SK E +W + + + EEL L Q
Sbjct: 1344 CDLLREQYEEEQEAKAE--LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
+ E E + ++ K + G VE LM +LE ++K ++ + ++ E
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
+E +K +EL + E +L + + KN E+ +D +
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 1472 QTESDAEELERRA----QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
+T + +E E+ QE + V ++ SL+ + + + +++ ++ E+++ V
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI 1581
Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKS 1587
KD + + L + ++ E LQ + D E+ RN+ L+ +K++
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVL-DAEIRSRNDALRLK----------------KKMEG 1624
Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKS 1647
+ + ++ +RQ+ ++ L +QG + ++ L +ALR E + R
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684
Query: 1648 LLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ-MSKHKTELKNILDMLQ 1706
LLEEL E+ V + + + L +QE+ + +Q++ Q S T+ K D+ Q
Sbjct: 1685 LLEELE----EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ 1740
Query: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766
+ ++ + R +E EK + A+ + + E L++ Q +E K+ LE+ +
Sbjct: 1741 CQAEVENSIQ---ESRNAE-EKAKKAITDAAMMAEELKK-EQDTSAHLERMKKNLEQTVK 1795
Query: 1767 EIERMTAESRAL-----QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
+++ E+ L + ++ L +L+ + D+ +K+ A+ + E K
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMT 1855
Query: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
E+ N+ +LQ +D+L S ++Q + +Q EL + +
Sbjct: 1856 YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERAD 1915
Query: 1882 LAKQDL 1887
+A+ +
Sbjct: 1916 IAESQV 1921
Score = 98.6 bits (244), Expect = 6e-20
Identities = 122/609 (20%), Positives = 251/609 (41%), Gaps = 43/609 (7%)
Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
S + + E+ K+ ER K E+ R A + L+ + L +EK DLQ
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 1794 -EKCD-IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
E+C+ + + K+ +V E + E+ N E L R L+ + L RD L
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEEEMNSE-LVAKKRNLEDKCSSLKRDIDDLELT 964
Query: 1852 ISAMQQQLQEKREAVNSLQEELANVQDHLN-LAKQDLLHTTKHQDVLLSEQTRLQK--DI 1908
++ ++++ V +L EE+ ++++++ L K+ HQ L Q K +
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
+ + E + E +Q + L+ ++E K KL M Q + E+++ ++E
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084
Query: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE----EERWCESLEKTLSQTK 2024
+ + QL+ ++ D++ Q K+ + R+ L+E E +EK S
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144
Query: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR 2084
R+L E ++L E SG A + A+F +R + E A+L++
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204
Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQK 2144
++L + + ++ ++KE + +++ D L K + ++ ++ Q + K
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK 1264
Query: 2145 DLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLK 2204
+ +Q ++ + K+ ++T L+ + E + + + + + L +LE LK
Sbjct: 1265 AKDEQQTQLIHDLNMQKA----RLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 2205 ENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLI 2264
M E E K + H + L + E KA+L+ +SK +
Sbjct: 1321 RQ----MEE---ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373
Query: 2265 KGK--------RQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLT-EDSQLG 2315
+ + ++TE + ++ L E +T ++ SL + + L E L
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Query: 2316 QNQEKNASA 2324
++ E++ +A
Sbjct: 1434 RDLERSHTA 1442
Score = 75.5 bits (184), Expect = 6e-13
Identities = 92/508 (18%), Positives = 212/508 (41%), Gaps = 64/508 (12%)
Query: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL 1888
L + ++E+ + D +++ + + +E E + SL +E ++Q + ++L+
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 1889 HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN----KLKLV 1944
+ + L+ + L+ + E R E EEE +L + +E+ K +
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLE----EEEEMNSELVAKKRNLEDKCSSLKRDID 959
Query: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK---ELTDQKSKLDQVLSKVLAAEE 2001
E+ +++KE+ + E+K++ L E+ LE+ +LT +K L + A ++
Sbjct: 960 DLELTLTKVEKEKHATENKVK----NLSEEMTALEENISKLTKEKKSLQE------AHQQ 1009
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
+ LQ EE L K ++ ++Q + E L ++ +RAD + +
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL-----------EQEKKLRADLERAKRK 1058
Query: 2062 FLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARR 2121
+ K +++ + L+ + Q+E+ L +++ E S +Q ++ D + +
Sbjct: 1059 LEGDLKMSQESIMDLEN----DKQQIEEKLKKKEFELSQLQAKI-------DDEQVHSLQ 1107
Query: 2122 LMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPE 2181
K++ ++Q EL++ ++E +R + + ++ L+ +++ L E
Sbjct: 1108 FQKKIKELQARIEELEE-----------EIEAEHTLRAKIEKQRSDLARELEEISERLEE 1156
Query: 2182 LPADLEAILERNENLEGELESLKEN-----LPFTMNEGPFEEKLNFSQVHIMDEHWRGEA 2236
A +E N+ E E + ++ + L +K S + ++ +
Sbjct: 1157 ASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQR 1216
Query: 2237 LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSA 2296
+++KL + LK ++ M+ E L K K E T ++ D E+ +
Sbjct: 1217 VKQKLEKEKSELKMEIDD-MASNIEALSKSKSNIERTCRTVE---DQFSEIKAKDEQQTQ 1272
Query: 2297 SSPSLSQLESSL-TEDSQLGQNQEKNAS 2323
L+ ++ L T++ +L E+ S
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKES 1300
Score = 46.6 bits (109), Expect = 3e-04
Identities = 49/230 (21%), Positives = 105/230 (45%), Gaps = 27/230 (11%)
Query: 2063 LTERKKAEKQVASLKEAL----------KIQRSQLEKNLLEQKQENSCIQKEMATIELVA 2112
L + +AEK++A++KE + +R +LE+ ++ QE + +Q ++ +
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 2113 QDNHERARRLMKELNQMQYEYTELKKQMANQK----DLERRQMEISDAMRTLKSEVKDEI 2168
D ER L+K ++ + EL +++ ++ +L ++ + D +LK ++ D
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD-- 960
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEE--KLNFSQV 2225
L L ++ + A + +NL E+ +L+EN+ T + +E + +
Sbjct: 961 ------LELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDL 1014
Query: 2226 HIMDEHWRG-EALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
+ ++ G + KL + D L+ L +A+ L + KR+ EG L
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD-LERAKRKLEGDL 1063
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 173 bits (439), Expect = 2e-42
Identities = 246/1080 (22%), Positives = 463/1080 (42%), Gaps = 176/1080 (16%)
Query: 1315 VPEHHNLENEVSRLEDIMQHLKSK--KREERWMRASKRQSEKEMEE------LHHNIDDL 1366
V E L++ V+ L Q L K+E+ + + ++ +E+ + + LH D
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 1367 LQEKKSLECEVEELHR----------TVQKRQQQKDFIDGNVESLMTEL-----EIEKSL 1411
Q + L LHR QK +++ ++ + L E + E+
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
+H + EI + LL+ +L EA L E + + EK + ++ D + L
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKE---QRQLSSEKLMDKEQQVADLQLKLS 463
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
+ E +E + E L K QQ + QA + + + L+++ + + KD
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
Query: 1532 DFQCLSKKKEKLTEELQKLQKDIE------MAERNEDHHLQVLKESEVLLQAKRAEL-EK 1584
Q L +K E + L+K+ E A E L L+E LQ + +L EK
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 1585 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
LK+Q S +Q +E LH +V E+ H+R
Sbjct: 584 LKNQSESHKQA-----------QENLH---------------------DQVQEQKAHLRA 611
Query: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDM 1704
+ + L ELN Q++E K +++ + +I+ + E L + + +L+N LD
Sbjct: 612 AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671
Query: 1705 ----LQLENHELQGLKLQHDQRVSELEKTQ--VAVLEEKLELENLQQISQQQKGE-IEWQ 1757
LQ + EL + Q DQ ++L+ Q + LE L+ + +S +QK E +E Q
Sbjct: 672 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731
Query: 1758 KQLLERDKREIERMTAESRALQSCVECLSKEKE---DLQEKCDIWEKKLAQTKRVLAAAE 1814
+ LE D E++ ++ +ALQ L ++++ DL+ + K+L K ++++
Sbjct: 732 IKKLEADSLEVK--ASKEQALQD----LQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRD-----------KLSLHNDISAMQQQLQEKR 1863
+ + + LE ++ + K ++E L +D L+N I +LQ+ +
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
+L EL+ V+D L+ K D L + ++ +K+ + D +K +
Sbjct: 846 MEKEALMTELSTVKDKLS----------KVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 1924 TKQQQLQV-LQNEIEENK---LKLVQQEMMFQRLQKERESEESKLETSKVTLKE---QQH 1976
+ QLQV ++N ++E K L +++ +L+ E S + +L ++ TLK+ ++
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 1977 QLEKELTDQKSKLDQVLSKV--LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQL 2034
QL+ + + K +Q ++ L E ++ LQ+ E LE L Q QL++ Q+L
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE-----LENKLQQ---QLTQAAQEL 1007
Query: 2035 VEKSGELLALQKEADSMRADFSLLRNQFL---TERKKAEKQVASLKEALKIQRSQLEKNL 2091
+ ++ LQ + + F L++ F +E + + S++E L + + L N
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 2092 LEQKQENSCIQKEMATIELVAQDNHERARRLM---KELNQMQYEYTELKKQMANQK---- 2144
+ +N IQ+ + QD+ ++ ++L K L +Q E + +K++ N+K
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 2145 DLE----RRQMEISDAMRTLKSEVKDEIR--TSLKNLNQFLPELPADLEAILERNENLEG 2198
++E R++ EI+ LKS + I+ T+LK+ Q L +++ L+G
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL----------IQQKLELQG 1177
Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQL------ 2252
+ +SLK + +EK N + L+++++ E+ LK +
Sbjct: 1178 KADSLKAAVE--------QEKRN------------QQILKDQVKKEEEELKKEFIEKEAK 1217
Query: 2253 RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGE-LVTSTSADSASSPSLSQLESSLTED 2311
H K+ EV +K + E L Q+ AL E L T +S +S+LE T+D
Sbjct: 1218 LHSEIKEKEVGMKKHEENEA---KLTMQITALNENLGTVKKEWQSSQRRVSELEKQ-TDD 1273
Score = 172 bits (436), Expect = 3e-42
Identities = 214/966 (22%), Positives = 416/966 (43%), Gaps = 101/966 (10%)
Query: 1323 NEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHN-------IDDLLQEKKSLEC 1375
++V+ L +Q L++ +EE+W ++ ++ + L + D E +SLE
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142
Query: 1376 EVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
++EE +Q KD + L TE+ KS E + E E+ + + EL
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE--AAEQKVTRLTEEL 200
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE----ELERRAQETAVNL 1491
+ ++ + ++EL + +E K+ L+Q ++ + E ER +++
Sbjct: 201 NKEATVIQDLKTELL-----QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
Query: 1492 VKADQQLRSLQADAKDLEQHKIK-QEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
K Q S +A L K +E+ + ++ K S + L++K + LTE L K
Sbjct: 256 KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE-LTQKNQTLTENLLKK 314
Query: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHK---- 1606
++D E + K + L K + ++L+S++++ + + + +L K
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 1607 ---KEELHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELN 1660
KEEL ++ KA+ LQ+ E + + I ++ S L E Q GE +
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 1661 VQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHD 1720
++ E++ + + E++ +LQ+ L ++ + E + + +L+ H+L K QH
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE--KVTNSTELQ-HQLDKTKQQHQ 491
Query: 1721 QRVSELEKTQVAVLEEKLELEN-LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
++ + + T + E + +LE L+QI + + +I+ + LL++ K I + E L
Sbjct: 492 EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLY 550
Query: 1780 SCVECLSKEK---EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQ 1836
+ ++ E LQEK ++++ Q L E+ K Q NL V++ +
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD---QVQEQKA 607
Query: 1837 ELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------------------ANVQD 1878
L LSL ++ + QL E +E V+ L ++ A++Q+
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 1879 HLNLAK---QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNE 1935
HL+ A+ QD L + T +D E ++ E KE + K L+ E
Sbjct: 668 HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 1936 IEENKLKL--------VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKS 1987
+E KL +E Q LQ++R+ + LE + T +Q ++EKE+ +
Sbjct: 728 LEGQIKKLEADSLEVKASKEQALQDLQQQRQL-NTDLEL-RATELSKQLEMEKEIV-SST 784
Query: 1988 KLD-QVLSKVLAAEERVRTLQEEERWC--ESLEKTLSQTKRQLSEREQQLVEKSGELLAL 2044
+LD Q S+ L + ++ T QEEE+ + E +TK Q E ++ EL +
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 2045 QKEADSMRADFSLL--------------RNQFLTERKKAEKQVASLKEALKIQRSQL--- 2087
+ E +++ + S + +++F E +K + + L++ K + QL
Sbjct: 845 KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ 904
Query: 2088 -EKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL 2146
E L EQK+ ++KE + + + +L++ N ++ E ++ N +L
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964
Query: 2147 ERRQMEISDAMRTLKSEVKDEI--RTSLKN-----LNQFLPELPADLEAILERNENLEGE 2199
++ + + L+ E+K + +T L+N L Q EL A+ E I N E
Sbjct: 965 KQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024
Query: 2200 LESLKE 2205
E+ K+
Sbjct: 1025 QETFKQ 1030
Score = 167 bits (423), Expect = 1e-40
Identities = 200/928 (21%), Positives = 414/928 (44%), Gaps = 117/928 (12%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
+L+ ++SRLE+ ++ + E + +Q +E + L + L+E ++ ++E+
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---DLEQ 513
Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSL--KHHEDIVDEIECIEKTLLKRRSELRE 1437
+ R + + Q+ N+E+L+ + + SL K ED+ +I+ E ++L+E
Sbjct: 514 VLRQIGDKDQKIQ----NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL-NQLQE 568
Query: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
+ L E ++L+ EK KN E A+ E L + QE +L A +
Sbjct: 569 KNHTLQEQVTQLT---EKLKNQSESHKQAQ----------ENLHDQVQEQKAHLRAAQDR 615
Query: 1498 LRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA 1557
+ SL+ +L + +E + +++ + AK K +LQ + A
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 1558 ERNEDHHLQV----LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
+++ L L + LQ K+ +L+S + +++ L+++ + ++ L
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 1614 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLI 1673
+ ++ KA ++AL+ +++ + L +L + EL+ Q+ K ++
Sbjct: 736 EADSLEVKASKEQALQ-----------DLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 1674 KQEIEKEEENLQVVLRQMSKHKTE---LKNILDMLQLENHELQGLKLQHDQRVSELEKTQ 1730
+ +++K+ E L+ + ++++K + E LK + L E K+QH++ + ++ T
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET------KIQHEELNNRIQTTV 838
Query: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKE-K 1789
+ + K+E E L K ++ L+ K E E+ + +A +E KE K
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLH 1849
LQ + + K+ + K+ L +E S + L ++ + + Q L Q +++ L
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 1850 NDISAMQQQLQEKREAVNSLQEELA-----------NVQDHLNLAKQDLLHTTKHQDVLL 1898
+I+ ++Q ++K++ + +LQ EL +Q L A Q+L + VL
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
+ + Q+ + + F + E +Q L+ + E KL L Q++++ R Q +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSV-----EEKLSLAQEDLISNRNQIGNQ 1073
Query: 1959 SEE-SKLETSKVTL------KEQQHQ---------------LEKELTDQKSKLDQVLSKV 1996
++ +L+T+K TL KEQQ Q EKEL ++KSKL ++ ++
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI-EEI 1132
Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS 2056
+E+ T EE LE T L + +Q L+++ L LQ +ADS++A
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITN--LKDAKQLLIQQK---LELQGKADSLKA--- 1184
Query: 2057 LLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNH 2116
E++K +Q+ LK+ +K + +L+K +E++ + + E+ E+ + +
Sbjct: 1185 ------AVEQEKRNQQI--LKDQVKKEEEELKKEFIEKEAK---LHSEIKEKEVGMKKHE 1233
Query: 2117 ERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLN 2176
E +L ++ + +KK+ + +RR E+ + D++R + L
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSS---QRRVSELE--------KQTDDLRGEIAVLE 1282
Query: 2177 QFLPELPADLEAILERNENLEGELESLK 2204
+ + A+LER EGE+E L+
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQ 1310
Score = 162 bits (411), Expect = 3e-39
Identities = 190/871 (21%), Positives = 393/871 (45%), Gaps = 115/871 (13%)
Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKR 1387
LE +++ + K ++ + + A ++S++ + L +DL + ++ E E L++ +K
Sbjct: 511 LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
Query: 1388 QQQKDFIDGNVESLMTELEIEKSLKH--HEDIV----------DEIECIEKTLLKRRSEL 1435
++ + E L + E K + H+ + D + +E ++ + S+L
Sbjct: 571 HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
Query: 1436 READRLLAE------AESELSCTKEKTKNA----VEKFTDAKRSLLQT-ESDAEELERRA 1484
E+ +++ A++EL + E K A ++ D ++ LQ + + ++ +
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 1485 QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLT 1544
+ L + L++ K+ ++ + E+ +E+ + ++D + KE+
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 1545 EELQK---LQKDIEMAERNEDHHLQVLKE----SEVLLQAKRAELEKLKSQVTSQQQEMA 1597
++LQ+ L D+E+ L++ KE + + LQ K LE +K ++T Q++E
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 1598 VLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKG 1657
+L + +E K +E +T VTE E ++L+ ELS K
Sbjct: 811 ILKQDFETLSQE----------TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
Query: 1658 ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKL 1717
+L S+ L K E EKE + + + + K ELK+ L + Q+EN LK
Sbjct: 861 KL----SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV-QMENT----LKE 911
Query: 1718 QHDQRVSELEKTQVAVLEEKLELENLQQI--------------SQQQKGEIEWQKQLLER 1763
Q + + S LEK + A + KLEL ++Q+ QQ +G I KQ E+
Sbjct: 912 QKELKKS-LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
K++IE ALQ ++ +K +L+ K +++L Q + LAA +E + Q+N
Sbjct: 971 KKKQIE-------ALQGELKIAVLQKTELENKL---QQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
EK Q+ QL D +++ A +Q L+ E ++ QE+L + ++ +
Sbjct: 1021 YEKS-------QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
+ + + L + + ++ + E +D QKE+ K+++L ++++ E +
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133
Query: 1944 VQQEMMFQRLQKERESEESKLETSK--VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
+QE +L +E +S KLE+ K LK+ + L ++ + + K D + + V
Sbjct: 1134 CRQEKEITKLNEELKSH--KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV----- 1186
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
E+E+ + + K Q K++ E +++ +EK +L + KE + + +
Sbjct: 1187 ------EQEKRNQQILK--DQVKKEEEELKKEFIEKEAKLHSEIKEKE-------VGMKK 1231
Query: 2062 FLTERKKAEKQVASLKEAL---KIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHER 2118
K Q+ +L E L K + ++ + E +++ ++ E+A +E Q+N +
Sbjct: 1232 HEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291
Query: 2119 ARRLMK-------ELNQMQYEYTELKKQMAN 2142
R L++ E+ ++Q + EL++++ N
Sbjct: 1292 RRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
Score = 139 bits (350), Expect = 3e-32
Identities = 200/937 (21%), Positives = 416/937 (44%), Gaps = 118/937 (12%)
Query: 240 TIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEE 299
TI LRS + Q V ++ + S+ E+ + + L + +++ E+ +K LEE
Sbjct: 268 TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK----LEE 323
Query: 300 IKNQDKLNKSLKEEAMLQKQ-SCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAF 358
N++ ++K + + QK C++L+S L+ L + +EL+ + +L++EL+
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS- 382
Query: 359 YKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEP 418
+++ K++ L +E+ ++ + +E G + + K +E
Sbjct: 383 -EVETKYQHLK---AEFKQLQQQREEKEQHGLQ------------LQSEINQLHSKLLET 426
Query: 419 DEQLRNDHMNLRGHTPLDTQ-LEDKEKKISAAQTRLSELHDEIEKAE------QQILRAT 471
+ QL H L+ L ++ L DKE++++ Q +LS L +++++ Q L T
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 472 EEFKQLEEAIQLK---KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAG 528
++ Q ++A+Q K+ EA DL +Q+ L+ + Q+ +LE ++K K+ I+
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDL--EQV---LRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 529 KQKEIKDLQIAIDSLDS--------------------------KDPKHSHMKAQKSGKEQ 562
+KE +DL I + + K+ SH +AQ++ +Q
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
Query: 563 ------QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL---TEGQIAANEA---- 609
L + LE+ ++E+ S++ + E++ L+ Q+ TE ++A A
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
Query: 610 ---LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIV 666
L+ L+ + LQ+ + TQ KL+D++E Q + +++ +++ +
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 667 AMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN---QLK 723
E + ++ +LE+ + EV AS +Q DL + +L L LR E + +++
Sbjct: 722 EQKTEELEGQIKKLEA---DSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLEME 777
Query: 724 EELEKVTRLT-QLEQSALQA------ELEKERQALKNALGKAQFSEEKEQENSELH---- 772
+E+ TRL Q + AL++ + E+E+Q LK S+E + ++ EL+
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF--ETLSQETKIQHEELNNRIQ 835
Query: 773 ---AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK--LKLGTGEM 827
+L+ ++ + L +L ++ L+ V D L + + ++ + L L
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 828 NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR 887
+ V ++ QK+ + L + K + ++ +QE++ Q L ++E +
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 888 QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
Q E + + ++++ + Q E +I LQ+ + Q LT QE EKE+I
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ-AAQELAAEKEKI 1014
Query: 948 LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLK---KAVATSDKLATAELTIAKDQLKSL 1004
EK ++ + Q +G + EL + K+V LA +L ++Q+ +
Sbjct: 1015 SVLQNNYEKSQE-TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQ-NLLRQKGEQFRLEMEK 1063
+ + ++ +A Q++ + ++ + + L + E L + L+ +K + +E K
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133
Query: 1064 TGVGTGANSQVLEIEKLNETMERQRTE-IARLQNVLD 1099
Q EI KLNE ++ + E I + N+ D
Sbjct: 1134 C-------RQEKEITKLNEELKSHKLESIKEITNLKD 1163
Score = 125 bits (314), Expect = 5e-28
Identities = 181/922 (19%), Positives = 402/922 (43%), Gaps = 126/922 (13%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
+EV+ L+ L+++ +EELK + ++ + ++ Q+ L ++ + QS E+ +
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKY-QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ 148
Query: 330 TKN-------ELLKQKTIELTRAC---QKQYELEQEL---AFYKIDAKFEPLNYYPSEYA 376
T+N +L +QK +L + +Y+ E+ L A K+ E LN +
Sbjct: 149 TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQ 208
Query: 377 EIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
++ + P I E + + VQ++ + + L + R L
Sbjct: 209 DLKTELLQRPGI------------EDVAVLKKELVQVQTLMDNMTLERE----RESEKLK 252
Query: 437 TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLY 495
+ + + + ++++ +S+L E+ K Q++ +E ++L+ ++ +L + ++ + L
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 496 KQLSGRLQLVNKLRQEALDL----------ELQMEKQKQEIAGKQKEIKDLQIAI----- 540
K+ +L K +E++ +L ++ + ++ + + + + +
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 541 ------DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKD 594
+ L + K+ H+KA+ +QQ + + QL+S ++++ S++ + ++ +
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 595 LEEQLTEGQIAANEALK------KDLEGVISGLQEYLGTIKGQATQAQNECRKLR---DE 645
+L E + ++E L DL+ +S L+E L +T+ Q++ K + E
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
Query: 646 KETLLQRLT-EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDL--- 701
++ L Q T ++ + ++ LE V + +++ LE+ LQ+ E + L++ + DL
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
Query: 702 -------SAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA 754
+A +L+ + + + QL E+L+ + + Q L ++++++ L+ A
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
Query: 755 LGK------------AQFSEEKE---QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
+ +Q +E KE Q + ++ AK + L Q D QNHL+
Sbjct: 613 QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 800 VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
+ L ++ EL + I + D + L D Q+ S++ + K ++
Sbjct: 673 QNALQDKQQ------ELNK----------ITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
Query: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
+ E+K EE+ Q +KL E + + E+AL+ D +Q +E L
Sbjct: 717 KYLSLEQK-TEELEGQIKKLEADSLEVKASKEQALQ-----DLQQQRQLNTDLELRATEL 770
Query: 920 QENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL---------EDAKSQEQVF 970
+ L+ +EI T L LQ+ E E I +L + E++K++ ++ K Q +
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Query: 971 G--LDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRK 1028
+ + +L+K + L T EL+ KD+L + ++ E +E Q+ +
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMT-ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889
Query: 1029 AAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTG---VGTGANSQVLEIEKLNETME 1085
+ ++L + + ++++ L QK + LE EK + NS ++ + T++
Sbjct: 890 LEKTCKEL-KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948
Query: 1086 RQRTEIARLQ-NVLDLTGSDNK 1106
+ E +LQ N+ +L S +
Sbjct: 949 QNEKEEQQLQGNINELKQSSEQ 970
Score = 124 bits (310), Expect = 1e-27
Identities = 148/685 (21%), Positives = 308/685 (44%), Gaps = 85/685 (12%)
Query: 1312 HCNVPEHH---------NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHN 1362
HC+ E H +LE + LE ++ L++ E ++ASK Q+ +++++
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE---VKASKEQALQDLQQQRQL 759
Query: 1363 IDDL----LQEKKSLECE-----------------VEELHRTVQKRQQQKDFIDGNVESL 1401
DL + K LE E +E + + + K++++K + + E+L
Sbjct: 760 NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Query: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE 1461
E +I+ HE++ + I+ L K + E L+ + +LS + KN+
Sbjct: 820 SQETKIQ-----HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 1462 KFTD----AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
+F K ++L E +EL+ + Q N +K ++L+ K LE+ K +
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK------KSLEKEKEASHQ 928
Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQA 1577
+ E+N + + Q K+ EK ++LQ +++ + + ++ L+ +
Sbjct: 929 LKLELNSM-QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
Query: 1578 KRAELE-KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1636
++ ELE KL+ Q+T QE+A +KE++ +LQ + +++ ++ +
Sbjct: 988 QKTELENKLQQQLTQAAQELAA-------EKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
Query: 1637 EKCNHIREVKSLLEELSF----------QKGELNVQISERKTQLTLIKQEIEKEEENLQV 1686
E +++KS+ E+LS Q G N I E KT ++Q+ K+E+ LQ
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 1687 ---VLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL-EKTQVAVLEEKLELEN 1742
L+ + K K+ + L + + E++ +K + ++ +++L E+ + LE E+ N
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160
Query: 1743 LQQISQ---QQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIW 1799
L+ Q QQK E++ + L K +E+ E R Q + + KE+E+L+++ +
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSL---KAAVEQ---EKRNQQILKDQVKKEEEELKKE---F 1211
Query: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
+K A+ + E K + N KL + + L + L + ++ S +S +++Q
Sbjct: 1212 IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQT 1271
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQ 1919
+ R + L+ + N QD + L + L ++ LQ+ + ++
Sbjct: 1272 DDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331
Query: 1920 KEEETKQ-QQLQVLQNE-IEENKLK 1942
+E ++ Q + Q L + E+N+++
Sbjct: 1332 RENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 119 bits (297), Expect = 5e-26
Identities = 151/769 (19%), Positives = 335/769 (43%), Gaps = 88/769 (11%)
Query: 1319 HNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE 1378
++L+ + L+D Q L + + A + ++ +L ++ + ++ SLE + E
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLK-----HHEDIVDEIECIEKTLLKRRS 1433
EL ++K + + + E + +L+ ++ L ++ ++E ++ + R
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
+L++ L + +L TK++ + + K D + +T+ EEL R Q T L K
Sbjct: 787 DLQKKSEALESIKQKL--TKQEEEKQILK-QDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
+ +L + ++ K + LK S+F+ ++K + +L+K K+
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKN-------SKSEFEKENQKGKAAILDLEKTCKE 896
Query: 1554 IE-MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL 1612
++ + ++ L+ KE + L+ ++ +LK ++ S Q+++ L ++E
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 1613 LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTL 1672
LQG++ + K + +K I ++ L+ QK EL ++ + QLT
Sbjct: 957 LQGNINELKQSSE-----------QKKKQIEALQGELKIAVLQKTELENKLQQ---QLTQ 1002
Query: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
QE+ E+E + V+ K + K LQ + + + L Q + +E+ +++
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFK----QLQSDFYGRESELLATRQDLKSVEE-KLS 1057
Query: 1733 VLEEKLELENLQQISQQQK--GEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKE 1790
+ +E L + N QI Q K E++ K LE+D + E+ E K +
Sbjct: 1058 LAQEDL-ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER----------CKALQ 1106
Query: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN 1850
D+Q++ + EK+L K LA EE ++ + KL ++L KL
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN----------EELKSHKLESIK 1156
Query: 1851 DISAMQQQLQEKREAVNSLQEELANVQDHLNLA-KQDLLHTTKHQDVLLSEQTRLQKDIS 1909
+I+ L++ ++ + + EL D L A +Q+ + +D + E+ L+K+
Sbjct: 1157 EIT----NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
Query: 1910 EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV 1969
E ++ + E K++++ + ++ EEN+ KL Q + L +
Sbjct: 1213 E-----KEAKLHSEIKEKEVGMKKH--EENEAKLTMQ--------------ITALNENLG 1251
Query: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCESLEKTLSQTKR 2025
T+K++ ++ +++ + + D + ++ E V+ Q+E R C E + + +
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT 1311
Query: 2026 QLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
++ E +++L + + L +E S++ + N+ E + + +A
Sbjct: 1312 KVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMA 1360
Score = 117 bits (293), Expect = 1e-25
Identities = 200/910 (21%), Positives = 410/910 (45%), Gaps = 112/910 (12%)
Query: 173 KLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKL-KPLQDLISLI------- 224
KL A N++E + +G K ++ NL+ S ++IS L K +DL + I
Sbjct: 503 KLREAQNDLEQVLRQIGDK--DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 225 LVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQE----------AFERFSLEEVER 274
V N + H LQ + L E L+ Q + + QE A R + + V
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLT--EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
Query: 275 LERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL 334
LE + + + E K K ++ +IK + +L S + Q+ +L++ L+T
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA---DLQNHLDTAQNA 675
Query: 335 LKQKTIELTRACQKQYELEQELAFYKIDAKFEP-------LNYYPSEYAEIDKAPDESPY 387
L+ K EL + +L+Q A K+ K E L Y +Y +++ +E
Sbjct: 676 LQDKQQELNKITT---QLDQVTA--KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL-- 728
Query: 388 IGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKIS 447
+ + K+ +S + +++ ++ ++ QL D + LR T L QLE +++ +S
Sbjct: 729 --EGQIKK--LEADSLEVKASKEQALQDLQQQRQLNTD-LELRA-TELSKQLEMEKEIVS 782
Query: 448 AAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVN- 506
+ + L + + +E +Q++ + EE + L++ + +S+ K + +++L+ R+Q
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQ--DFETLSQETK-IQHEELNNRIQTTVT 839
Query: 507 -----KLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKE 561
K+ +EAL EL K K L DSL K+ K K + GK
Sbjct: 840 ELQKVKMEKEALMTELSTVKDK------------LSKVSDSL--KNSKSEFEKENQKGKA 885
Query: 562 QQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGL 621
LD+ K ++L+ +L + KE +E+K E+ E A+ LK +L + L
Sbjct: 886 AILDL-EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE----ASHQLKLELNSMQEQL 940
Query: 622 QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL---- 677
+ T+K + Q + + K++ Q+ ++E + +L+I + + +L
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 678 --------AELE--SALQEQHEVNA-SLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL 726
AE E S LQ +E + + +Q Q D E+EL A +D ++ + K L
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA--TRQDLKSVEEKLSL 1058
Query: 727 EKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLK 786
+ ++ Q Q +L +E + K L Q S +KEQ+ E L+ +Q + +L +
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATL--EQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
Query: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE--MNIHSPSDVLGKSLADLQ 844
++L + ++ L + + R E+ +++E + KL + + N+ +L + +LQ
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176
Query: 845 KQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF--RQACERALEARMNFDK 902
+ + A + E+ Q+ L++++ ++E+L ++EF ++A +
Sbjct: 1177 GKADSLKAAVEQEKRNQQI----LKDQVKKEEEEL---KKEFIEKEAKLHSEIKEKEVGM 1229
Query: 903 RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
++HE ++ +I L ENL ++++ + ++ E +++ + + ++ LE +
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ--- 1286
Query: 963 AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE-RAEELQE 1021
+Q++ L L++ K +KL T L + + +L + V ++ +E ++ +++
Sbjct: 1287 -NNQDERRAL---LERCLKGEGEIEKLQTKVLELQR-KLDNTTAAVQELGRENQSLQIKH 1341
Query: 1022 AERFSRKAAQ 1031
+ +RK A+
Sbjct: 1342 TQALNRKWAE 1351
Score = 102 bits (254), Expect = 4e-21
Identities = 101/477 (21%), Positives = 217/477 (45%), Gaps = 45/477 (9%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
+LE E + L S + + + + +Q+EKE ++L NI++L Q + + ++E
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
L ++ QK ++ ++ +T+ E + + ++I ++ K + ++
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQELAAEK-----EKISVLQNNYEKSQETFKQLQ 1032
Query: 1440 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESD-------AEELERRAQETAVNLV 1492
ESEL T++ K+ EK + A+ L+ + +EL+ +
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 1493 KADQQLRSLQADAKDLEQHK-IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
K +QQL+ +D+++ K +K++E++ E +K+ A+ + +C +K E+ KL
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL--AEIEEIKCRQEK------EITKLN 1144
Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAEL----EKLKSQVTSQQQEMAVLDRQLGHKK 1607
++++ + + LK+++ LL ++ EL + LK+ V +++ +L Q+ ++
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERK 1667
EE L+ ++ +A L ++ E EV K + E K L +QI+
Sbjct: 1205 EE---LKKEFIEKEAKLHSEIK--EKEVGMKKHEENEAK------------LTMQITALN 1247
Query: 1668 TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELE 1727
L +K+E + + + + +Q + E+ + +Q E + L + + E+E
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
K Q VLE + +L+N Q+ E + L + + + R AE +Q+C+ C
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRE---NQSLQIKHTQALNRKWAEDNEVQNCMAC 1361
Score = 99.0 bits (245), Expect = 5e-20
Identities = 183/859 (21%), Positives = 360/859 (41%), Gaps = 137/859 (15%)
Query: 152 LNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDI 211
L + +++ +E N N Q LN + ++ + + + K K+ +L+ + K + D+
Sbjct: 609 LRAAQDRVLSLETSVNELNSQ-LNESKEKVSQLDIQI--KAKTELLLSAEAAKTAQRADL 665
Query: 212 SK--------LKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
L+ Q ++ I + VT LQ H LES +E
Sbjct: 666 QNHLDTAQNALQDKQQELNKITTQLDQVTAK--LQDKQEHCSQLES---------HLKEY 714
Query: 264 FERF-SLEE-VERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSC 321
E++ SLE+ E LE ++K ++ E+K+ + + L++++ Q +LN L+ A +
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 322 EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKA 381
E K +++ L++K+ L QK + E+E K D FE L+
Sbjct: 775 EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD--FETLS------------ 820
Query: 382 PDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED 441
Q K++ +E +N R T + T+L+
Sbjct: 821 ------------------------------QETKIQHEE------LNNRIQTTV-TELQK 843
Query: 442 KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGR 501
+ + A T LS + D++ K + + EF E+ Q K + + K+L +
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF---EKENQKGKAAILDLEKTCKELKHQ 900
Query: 502 LQL-VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK 560
LQ+ + +E +L+ +EK+K+ + E+ +Q + + ++ + Q G
Sbjct: 901 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 561 EQQLDIMNKQ-YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVIS 619
+L ++Q +Q+E+ E+ + ++TE L++QLT Q A A +K+ V+
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT--QAAQELAAEKEKISVLQ 1018
Query: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAE 679
E K Q T Q + E E L R +++ ++L + D + R ++
Sbjct: 1019 NNYE-----KSQETFKQLQSDFYGRESELLATR-QDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 680 LESALQEQHEVNASLQQTQGDLSAYEAELEARLN-LRDAEANQLKEELEKVTRLTQLEQS 738
+QE A+L+Q D + E +L+ R L+D + + +E E V ++L
Sbjct: 1073 QNKLIQELKTAKATLEQ---DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL--- 1126
Query: 739 ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
AE+E+ + + + K +EE + E ++ +L+D LL QQ + Q
Sbjct: 1127 ---AEIEEIKCRQEKEITK--LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG---- 1177
Query: 799 VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
+ + + A V++ +R N D + K +L+K+F E A+ E
Sbjct: 1178 ------KADSLKAAVEQEKR---------NQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222
Query: 859 DEAQV-------RERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ 911
E +V E KL ++ E L T ++E++ + R E E +
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL---------EKQTDD 1273
Query: 912 MENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFG 971
+ EI L+ +++ ++ + + + + E E++ Q + LE ++KL++ + Q G
Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL--QTKVLELQRKLDNTTAAVQELG 1331
Query: 972 LDKELKKLKKAVATSDKLA 990
+ + ++K A + K A
Sbjct: 1332 RENQSLQIKHTQALNRKWA 1350
Score = 92.0 bits (227), Expect = 6e-18
Identities = 139/666 (20%), Positives = 290/666 (43%), Gaps = 115/666 (17%)
Query: 470 ATEEFKQLEEAIQLKKISEAGKDLLY---KQLSGRLQLVNKLRQEALDLELQMEKQKQEI 526
A E FK E + +AG D + L+ + V LRQE DL+ ++++K
Sbjct: 53 ADELFKHYEA------VHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYS 106
Query: 527 AGKQKEIK---------------------DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLD 565
+KE++ +LQ L+ ++ ++K K EQ+
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166
Query: 566 IMNKQYQQLESRLDE--------------ILSRIAKETEEIKDLEEQLTEGQ-IAANEAL 610
+ + ++S+ DE + + KE I+DL+ +L + I L
Sbjct: 167 QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 611 KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE----KETLLQRLTEVEQERDQLEIV 666
KK+L V + + + ++ + ++EC+KL+ + + T+ Q +E+ + ++ +
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 667 AMDAENMRKELAEL--------ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAE 718
+ + ++ + EL E+ L+++ + L++ + S + ++A L+ +D +
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDY-TKLEEKHNEESVSKKNIQATLHQKDLD 345
Query: 719 ANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHL 778
QL+ +RL+ E S + +E K + +++ ++E SE+ K +HL
Sbjct: 346 CQQLQ------SRLSASETSLHRIHVELSE--------KGEATQKLKEELSEVETKYQHL 391
Query: 779 QDDNNLLKQQLKDFQNH-------LNHVVDGLVRPE----EVAARVDELRR--KLKLGTG 825
+ + L+QQ ++ + H +N + L+ E E R+ E R+ KL
Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 826 EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQE---KLATG 882
E + L L+ L++Q E + S + + +++ QE+ ALQQ KL
Sbjct: 452 EQQVAD----LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 883 QEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQ-EAD 941
Q + Q R DK Q +IQ +E + +EN+ +E+ + DL + +A
Sbjct: 508 QNDLEQV------LRQIGDKDQ---KIQNLEALLQKSKENISLLEKER--EDLYAKIQAG 556
Query: 942 EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
E + +L QL+E + + + E++ + K+ ++ + + A L A+D++
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 1002 KSLHGTVMKINQERAEELQEAERFSRK---------AAQAARDLTRAEAE--IELLQNLL 1050
SL +V ++N + E ++ + + +A+AA+ RA+ + ++ QN L
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
Query: 1051 RQKGEQ 1056
+ K ++
Sbjct: 677 QDKQQE 682
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 170 bits (430), Expect = 2e-41
Identities = 230/1044 (22%), Positives = 473/1044 (45%), Gaps = 116/1044 (11%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + + ++ + A KR+ E E EL +IDDL +E E V+
Sbjct: 921 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
++ +D + L E +K+L+ H+ +D+++ E TL K +++L ++ D
Sbjct: 981 NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD 1037
Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
L E E +L E+ K +E A+ S + TE+D ++L + ++ + +
Sbjct: 1038 LEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGK 1097
Query: 1498 LRSLQADAKDLEQHKIKQ-EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
+ QA A L Q KIK+ + ++E+ + + A+ + K++ L+ EL+++ + +E
Sbjct: 1098 IEDEQALAIQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELE----------------------KLKSQVTSQQQ 1594
A +++ K+ E Q R +LE +L Q+ S Q+
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216
Query: 1595 EMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
L+++ K E++ L +M +AKA+ ++ R E +++E E + L+ E
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE 1276
Query: 1652 LSFQK-------GELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
LS QK GE + Q+ E+ +QL+ KQ ++ E L+ L + +K K+ L +
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHA 1336
Query: 1702 L-------DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI 1754
L D+L+ + E Q K + + +S+ ++VA K E + +Q+ + ++ +
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSK-ANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL-------QEKCDIWEKKLAQTK 1807
+ ++L + ++ +E + ++ +L+ + L E EDL C +KK
Sbjct: 1396 KLAQRLQDAEE-HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454
Query: 1808 RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVN 1867
+VL AE K E++ Q EL+ ++ SL ++ ++ +E + +
Sbjct: 1455 KVL--AEWKQKYEET------------QAELEASQKESRSLSTELFKVKNAYEESLDHLE 1500
Query: 1868 SLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQ---KEEET 1924
+L+ E N+Q ++ + + KH L + +L + SE E+ + + EE
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEG 1560
Query: 1925 KQQQLQVLQNEIE-ENKLKLVQQEMMFQRLQKER----ESEESKLETSKVTLKEQQHQLE 1979
K ++Q+ N+++ E K+ +++ +L++ ES +S L+ +++ + +++
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLD-AEIRSRNDALRIK 1619
Query: 1980 KELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
K++ ++++ L+ A E +R L+ + + + L R + ++QL
Sbjct: 1620 KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE 1679
Query: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKI---QRSQLEKNLLEQK 2095
+Q E + +RA SL R + RK AE+++ E +++ Q + L + +
Sbjct: 1680 RRANLMQAEVEELRA--SLERTE--RGRKMAEQELLDASERVQLLHTQNTSLINTKKKLE 1735
Query: 2096 QENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISD 2155
+ S IQ EM I A++ E+A++ + + M ELKK+ LER + +
Sbjct: 1736 TDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMA---EELKKEQDTSAHLERMKKNMEQ 1792
Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES-LKENLPFTMNEG 2214
++ L+ + + + +LK + + +L A R LE E+ES K N+ +G
Sbjct: 1793 TVKDLQLRLDEAEQLALKGGKKQIQKLEA-------RVRELESEVESEQKHNVEAV--KG 1843
Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
+ + ++ E R LR L+ D+L+ +++ +QAE + + Q+ L
Sbjct: 1844 LRKHERRVKELTYQTEEDRKNILR--LQDLVDKLQTKVK-AYKRQAE---EAEEQSNVNL 1897
Query: 2275 HSLRRQVDALGELVTSTSADSASS 2298
R+ L E AD A S
Sbjct: 1898 AKFRKLQHELEE--AKERADIAES 1919
Score = 163 bits (413), Expect = 2e-39
Identities = 222/1060 (20%), Positives = 463/1060 (43%), Gaps = 153/1060 (14%)
Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS 1410
++EKEM + + +E E + +EL + Q+K+ + +L+++
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL---------QLQVQAE 898
Query: 1411 LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
D + + + KT ++ ++++E AE E E++ + T KR L
Sbjct: 899 ADALADAEERCDQLIKTKIQLEAKIKEVTE-RAEDEEEINA----------ELTAKKRKL 947
Query: 1471 LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
E + EL++ + + L K +E+ K E +K + + +A D
Sbjct: 948 ---EDECSELKKDIDDLELTLAK--------------VEKEKHATENKVKNLTEEMAGLD 990
Query: 1531 SDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590
L+K+K+ L E Q+ D++M E+ + L +++ L+ + +LE +
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQM----EEDKVNTLTKAKTKLEQQVDDLEG-----S 1041
Query: 1591 SQQQEMAVLDRQLGHKKEE--LHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREV 1645
+Q++ +D + +K E L L Q S + + D L E L+ E E++ I +
Sbjct: 1042 LEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE 1101
Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
++L +L + EL +I E +++EIE E + +Q S EL+ I + L
Sbjct: 1102 QALAIQLQKKIKELQARIEE-------LEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 1706 ---------QLE---NHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGE 1753
Q+E E + K++ D S L+ A K +++ ++ +Q
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELG-EQIDS 1213
Query: 1754 IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1813
++ KQ LE++K E++ E L S +E +SK K + ++ C E +L++ K
Sbjct: 1214 LQRVKQKLEKEKSELK---MEINDLASNMETVSKAKANFEKMCRTLEDQLSEIK--TKEE 1268
Query: 1814 EENSKMEQSNLEKLELNV------RKLQQE---LDQLNRDKLSLHNDISAMQQQLQEKRE 1864
E+ + + + +K L+ R+L ++ + QL+R K + I +++QL+E+ +
Sbjct: 1269 EQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETK 1328
Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED--CQKEE 1922
A ++L L + + +L ++ + + L ++ ++++W ++E Q+ E
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 1923 ETKQ------QQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK---VTLKE 1973
E ++ Q+LQ + +E K E QRLQ E E +E S + L +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK 1448
Query: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE-----ERWCESLE--KTLSQTKRQ 2026
+Q +K L + K K ++ +++ A+++ R+L E + ESL+ +TL + +
Sbjct: 1449 KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKN 1508
Query: 2027 LSEREQQLVEKSG-------ELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
L + L E+ EL ++K+ D +++ + + E ++ ++
Sbjct: 1509 LQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLE 1568
Query: 2080 LKIQRSQLEKNLLEQKQENSCIQKEMATI----------ELVAQDNHERARRLMK-ELNQ 2128
L +S++++ + E+ +E +++ + E+ ++++ R ++ M+ +LN+
Sbjct: 1569 LNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNE 1628
Query: 2129 MQYEYTELKKQMA--------NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLP 2180
M+ + +Q A Q L+ Q+ + DA+R + ++K+++ + N
Sbjct: 1629 MEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRG-QDDLKEQLAMVERRANLMQA 1687
Query: 2181 ELPADLEAILERNEN----LEGELESLKE--NLPFTMNEGPFEEKLNFSQVHIMDEHWRG 2234
E+ +L A LER E E EL E L T N K + I
Sbjct: 1688 EV-EELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKL-ETDISQIQGEM 1745
Query: 2235 EALREKLRHREDRLK------AQLRHCMSKQAEV---LIKGKRQTEGTLHSLRRQVDALG 2285
E + ++ R+ E++ K A + + K+ + L + K+ E T+ L+ ++D
Sbjct: 1746 EDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE 1805
Query: 2286 ELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQEKNASA 2324
+L A + +LE+ + E +S++ Q+ N A
Sbjct: 1806 QL-----ALKGGKKQIQKLEARVRELESEVESEQKHNVEA 1840
Score = 138 bits (348), Expect = 6e-32
Identities = 206/954 (21%), Positives = 414/954 (43%), Gaps = 120/954 (12%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
EE E+ + +L K + +EL+ K ++E KN +L + +A+ ++ C++L +
Sbjct: 858 EEFEKTKEELAKTEAKRKELEEKMVTLMQE-KNDLQLQVQAEADALADAEERCDQL---I 913
Query: 329 NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
TK +L + K E+T + + E+ EL K K E E +E+ K D+ +
Sbjct: 914 KTKIQL-EAKIKEVTERAEDEEEINAELTAKK--RKLE------DECSELKKDIDDLE-L 963
Query: 389 GKSRYKRNMFATESYIIDSAQAVQ-----IKKMEPDEQ-LRNDHMNLRGHTPLDTQLEDK 442
++ ++ ATE+ + + + + I K+ +++ L+ H ++ EDK
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME---EDK 1020
Query: 443 EKKISAAQTRLSELHDEIE---KAEQQILRATEEFKQ-LEEAIQLKKISEAGKDLLYKQL 498
++ A+T+L + D++E + E+++ E K+ LE ++L + S + +QL
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL 1080
Query: 499 SGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKS 558
+ +L+ K E +L+ ++E ++ QK+IK+LQ I+ L+ + +A ++
Sbjct: 1081 NEKLK---KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE---RASRA 1134
Query: 559 GKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK-----------DLEEQLTEGQIAAN 607
E+Q ++++ +++ RL+E + + E K DLEE + + A
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA- 1193
Query: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
AL+K ++ L E + +++ + + E +L+ E L + V + + E +
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMC 1253
Query: 668 MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE 727
E+ +L+E+++ +EQ + L + L E +L+ +DA +QL +
Sbjct: 1254 RTLED---QLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQ 1310
Query: 728 KVTRLTQLEQSALQAELE-KERQALKNALGKA---------QFSEEKEQE---------- 767
T+ Q+E+ Q E E K + L +AL A Q+ EE+E +
Sbjct: 1311 AFTQ--QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKA 1368
Query: 768 NSELHA-----------KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816
NSE+ + + L++ L Q+L+D + H+ V A +++
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV-------NSKCASLEKT 1421
Query: 817 RRKLKLGTGEMNIH-SPSDVLGKSLADLQKQFSEILARSKWERDEAQVR-ERKLQEEMAL 874
+++L+ ++ I S+ +L Q+ F ++LA K + +E Q E +E +L
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL 1481
Query: 875 QQE--KLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN--EIHYLQENLKSMEEIQ 930
E K+ EE E N + + Q E IH L++ K ++ +
Sbjct: 1482 STELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEK 1541
Query: 931 GLTDLQLQEAD----EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATS 986
L+EA+ E+ +IL EL + K D K E+ LD+ + + V +
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESM 1601
Query: 987 DKLATAELTIAKDQL---KSLHGTVMKI-------NQERAEELQ----------EAERFS 1026
AE+ D L K + G + ++ N++ AE L+ + +
Sbjct: 1602 QSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHL 1661
Query: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETME 1085
A + DL A +E NL++ + E+ R +E+T G A ++L+ + + +
Sbjct: 1662 DDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLH 1721
Query: 1086 RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKR 1139
Q T + + L+ S +G E++++E + + MA+ K+
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKK 1775
Score = 130 bits (327), Expect = 2e-29
Identities = 159/784 (20%), Positives = 343/784 (43%), Gaps = 99/784 (12%)
Query: 1578 KRAELEK----LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-----EAL 1628
K AE EK +K + ++E+A + K++EL +++Q K DLQ EA
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEA----KRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 1629 RLGETEVTEKCNHIREVKSLLE-------ELSFQKGELNVQISERKTQLTLIKQEIEKEE 1681
L + E E+C+ + + K LE E + + E+N +++ +K +L E++K+
Sbjct: 901 ALADAE--ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 1682 ENLQVVLRQMSKHKTELKNILDMLQLE-----------NHELQGLKLQHDQRVSELEKTQ 1730
++L++ L ++ K K +N + L E E + L+ H Q + +L+ +
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE 1018
Query: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQL---LERDKREIERMTAESRALQSCVECLSK 1787
V L+Q +G +E +K+L LER KR++E + + Q
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE---GDLKLAQESTMDTEN 1075
Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD-------Q 1840
+K+ L EK E +++ + + + + Q +++L+ + +L++E++ +
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT-KHQDVLLS 1899
+ + L ++ + ++L+E A ++ E + ++DL +T +H+ +
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195
Query: 1900 EQTRLQKDISEWANRFEDCQKEE---ETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
+ + ++E + + Q+ + E ++ +L++ N++ N + + + F+++ +
Sbjct: 1196 LRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRT 1255
Query: 1957 RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESL 2016
E + S+++T +E+Q +L EL+ QK++L + E R L E++ L
Sbjct: 1256 LEDQLSEIKTK----EEEQQRLINELSAQKARLH------TESGEFSRQLDEKDAMVSQL 1305
Query: 2017 EKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERK--------- 2067
+ +Q+ E ++QL E++ L S R D LLR Q+ E++
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 2068 -KAEKQVASLK-----------EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDN 2115
KA +VA + E L+ + +L + L + ++ + + A++E Q
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 2116 HERARRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKSEVKD--EIRTSL 2172
LM ++ + L K+ N K L + + + L++ K+ + T L
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485
Query: 2173 KNLNQFLPELPADLEAILERNENLEGELESLKENL-------------PFTMNEGPFEEK 2219
+ E LE + N+NL+ E+ L E + ++ E +
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQ 1545
Query: 2220 LNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRR 2279
+ + EH G+ LR +L +++K+++ ++++ E L + KR + S++
Sbjct: 1546 TSLEEAEASLEHEEGKILRIQL--ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQS 1603
Query: 2280 QVDA 2283
+DA
Sbjct: 1604 TLDA 1607
Score = 118 bits (296), Expect = 6e-26
Identities = 155/759 (20%), Positives = 325/759 (42%), Gaps = 82/759 (10%)
Query: 1349 KRQSEKEMEELHHNIDDLLQEKKSL---ECEVEELHRTVQKRQQQKDFIDGNVESLMTEL 1405
K++ EKE EL I+DL +++ + E++ RT++ + + + + L+ EL
Sbjct: 1218 KQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINEL 1277
Query: 1406 EIEKSLKHHED-----IVDEIECIEKTLLKRRS----ELREADRLLAEAESELSCTKEKT 1456
+K+ H E +DE + + L + + ++ E R L E E++ T
Sbjct: 1278 SAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE-ETKAKSTLAHA 1336
Query: 1457 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA----KDLEQHK 1512
+ D R + E +A+ +R A + V Q + DA ++LE+ K
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVA--QWRTKYETDAIQRTEELEEAK 1394
Query: 1513 IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA-------ERNEDHHL 1565
K + L++ + V A +S L K K++L E++ L D+E + ++ + +
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454
Query: 1566 QVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ 1625
+VL E + + +AELE + + S E+ + + L L+ + +LQ
Sbjct: 1455 KVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLK----RENKNLQ 1510
Query: 1626 EALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
+ + ++ E HI E++ + ++L +K EL + E + L E EE +
Sbjct: 1511 QEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL-------EHEEGKIL 1563
Query: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQ 1745
+ ++++ K+E+ + ++ EL LK H + V ++ T A + + + +++
Sbjct: 1564 RIQLELNQVKSEIDR---KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKK 1620
Query: 1746 ISQQQKGEIEWQKQLLERDKREIERMTAESRAL----QSCVECLSKEKEDLQE------- 1794
+ E+E Q R E R ++ + Q ++ + ++DL+E
Sbjct: 1621 KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVER 1680
Query: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISA 1854
+ ++ + ++ + + L E KM + L V+ L + L K L DIS
Sbjct: 1681 RANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1740
Query: 1855 MQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
+Q ++++ + +E N ++ A D +++E+ + ++D S R
Sbjct: 1741 IQGEMED-------IVQEARNAEEKAKKAITDA--------AMMAEELKKEQDTSAHLER 1785
Query: 1915 FEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 1974
+ K E + LQ+ +E E+ LK ++++ Q+L+ ES++E+ EQ
Sbjct: 1786 MK---KNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELESEVES------EQ 1834
Query: 1975 QHQLE--KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQ 2032
+H +E K L + ++ ++ + + + LQ+ + L+ + KRQ E E+
Sbjct: 1835 KHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQD---LVDKLQTKVKAYKRQAEEAEE 1891
Query: 2033 QLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEK 2071
Q + LQ E + + + +Q R K+ +
Sbjct: 1892 QSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSRE 1930
Score = 107 bits (268), Expect = 1e-22
Identities = 143/715 (20%), Positives = 308/715 (43%), Gaps = 108/715 (15%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM----RASKRQSEKEMEELHHNIDD-------LLQ 1368
N E LED + +K+K+ E++ + A K + E E +D+ L +
Sbjct: 1248 NFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLM---------------TELEIEKSL-- 1411
K++ ++EEL R +++ + K + ++S + E+++ +
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Query: 1412 ----------KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESE---LSCTKEKTKN 1458
K+ D + E +E+ K L++A+ + S+ L TK++ +N
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Query: 1459 AVEKFT-DAKRSLLQT----------ESDAEELERRAQETAVNLVKADQQLRSLQAD--- 1504
VE D +RS + E +++ +ET L + ++ RSL +
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487
Query: 1505 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
K+ + + E LK NK + + SD + K EL+K++K ++ +E
Sbjct: 1488 VKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD----HEKSE 1543
Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
LQ L+E+E L+ + ++ +++ ++ + E +DR++ K EEL L+ + ++
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSE---IDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
+Q L + E+ + + +R K + L E+ Q N Q +E L + ++
Sbjct: 1601 MQSTL---DAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK 1737
+ +L +R K +L + +++Q E EL+ L+ +R ++ + ++ E+
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRA-SLERTERGRKMAEQELLDASER 1716
Query: 1738 LELENLQQISQ-QQKGEIEWQKQLLERDKREI--ERMTAESRALQSCVECLS-----KEK 1789
++L + Q S K ++E ++ + +I E AE +A ++ + K++
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKE 1776
Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAAEENS-----KMEQSNLEKLELNVRKLQQELDQLNRD 1844
+D + +K + QT + L + + K + ++KLE VR+L+ E++ +
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKH 1836
Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
+ EAV L++ V++ ++D + + QD++ +L
Sbjct: 1837 NV-----------------EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV----DKL 1875
Query: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ-KERE 1958
Q + + + E+ +++ + + LQ+E+EE K + E +L+ K RE
Sbjct: 1876 QTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSRE 1930
Score = 79.7 bits (195), Expect = 3e-14
Identities = 105/542 (19%), Positives = 219/542 (40%), Gaps = 92/542 (16%)
Query: 1799 WEKKLAQTKRVLAAAEENSKME--QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
W K + K +L +AE +M + EK + + K + + +L ++L + + +Q
Sbjct: 833 WMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ 892
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
Q+Q + +A+ +E D L+ + +L+ I E R E
Sbjct: 893 LQVQAEADALADAEERC---------------------DQLIKTKIQLEAKIKEVTERAE 931
Query: 1917 DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQH 1976
D ++ + + L++E E K + E+ +++KE+ + E+K+
Sbjct: 932 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV------------ 979
Query: 1977 QLEKELTDQKSKLDQVLSKVL--------AAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
K LT++ + LD+ ++K+ A ++ + LQ EE +L K ++ ++Q+
Sbjct: 980 ---KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036
Query: 2029 EREQQLVEKSGELLALQKEADSMRADFSLLRNQFL-TERKKAEKQVASLKEALKIQRSQL 2087
+ E L ++ + L++ + D L + + TE K + L E LK +
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ-----LNEKLKKK---- 1087
Query: 2088 EKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE 2147
+ EM+ ++ +D A +L K++ ++Q EL++
Sbjct: 1088 --------------EFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE--------- 1124
Query: 2148 RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKEN- 2206
++E A R + + ++ L+ +++ L E A +E N+ E E + ++ +
Sbjct: 1125 --EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182
Query: 2207 ----LPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEV 2262
L +K S + ++ + +++KL + LK ++ ++ E
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIND-LASNMET 1241
Query: 2263 LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSL-TEDSQLG-QNQEK 2320
+ K K E +L D L E+ T LS ++ L TE + Q EK
Sbjct: 1242 VSKAKANFEKMCRTLE---DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298
Query: 2321 NA 2322
+A
Sbjct: 1299 DA 1300
Score = 77.4 bits (189), Expect = 2e-13
Identities = 112/518 (21%), Positives = 227/518 (43%), Gaps = 65/518 (12%)
Query: 650 LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAY-EAEL 708
L + E E+E ++ + E ++ELA+ E+ +E E +L Q + DL +AE
Sbjct: 843 LLKSAETEKEMANMK---EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEA 899
Query: 709 EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQEN 768
+A L DAE R QL ++ +Q E + +K +A E++E+ N
Sbjct: 900 DA---LADAEE-----------RCDQLIKTKIQLEAK-----IKEVTERA---EDEEEIN 937
Query: 769 SELHAKLKHLQDDNNLLKQQLKDFQNHL------NHVVDGLVR--PEEVAARVDELRRKL 820
+EL AK + L+D+ + LK+ + D + L H + V+ EE+A + + +
Sbjct: 938 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 997
Query: 821 KLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK-- 878
K H ++L DLQ + ++ +K + ++ ++ E +L+QEK
Sbjct: 998 KEKKALQEAHQ------QTLDDLQMEEDKVNTLTK---AKTKLEQQVDDLEGSLEQEKKL 1048
Query: 879 ---LATGQEEFRQACERALEARMNF--DKRQHEARIQQMENEIHYLQENLKSMEEIQGLT 933
L + + + A E+ M+ DK+Q ++++ E E+ LQ + E+ Q L
Sbjct: 1049 CMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI---EDEQALA 1105
Query: 934 DLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAE 993
+QLQ+ +E + + +L E + ++ AK+++Q L +EL+++ + + + +A+
Sbjct: 1106 -IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164
Query: 994 LTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
+ + K + + + + A +K A + +L ++ ++ L ++
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224
Query: 1054 GEQFRLEMEKTGVGTGANSQV-LEIEKLNETMERQRTEI-------ARLQNVLDLTGS-- 1103
+ ++E+ S+ EK+ T+E Q +EI RL N L +
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 1104 -DNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140
G F L+E + ++S + + KR+
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322
Score = 76.3 bits (186), Expect = 3e-13
Identities = 131/625 (20%), Positives = 253/625 (40%), Gaps = 64/625 (10%)
Query: 232 TLPHYLQFTIFHLRSL-ESLEGQPVTTQDRQEAFERFSLEEVE---RLERDLEKKMIETE 287
TL H LQ L E E + + Q + + E + + E D ++ E E
Sbjct: 1332 TLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391
Query: 288 ELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ 347
E K K + L++ + + S KQ + DL E I L +
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK--- 1448
Query: 348 KQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDS 407
KQ ++ LA +K Y AE++ + ES + +K ES
Sbjct: 1449 KQRNFDKVLAEWK--------QKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLE 1500
Query: 408 AQAVQIKKMEPD-----EQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEK 462
+ K ++ + EQ+ ++ + QL+ ++ ++ QT L E +E
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSEL---QTSLEEAEASLEH 1557
Query: 463 AEQQILRATEEFKQL------------EEAIQLKK----ISEAGKDLLYKQLSGR---LQ 503
E +ILR E Q+ EE QLK+ + E+ + L ++ R L+
Sbjct: 1558 EEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALR 1617
Query: 504 LVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS----LDSKDPKHSHMKAQKSG 559
+ K+ + ++E+Q+ ++ A + +++ Q + LD +K Q +
Sbjct: 1618 IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAM 1677
Query: 560 KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE--QLTEGQIAANEALKKDLEGV 617
E++ ++M + ++L + L+ +E+ D E QL Q + KK LE
Sbjct: 1678 VERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
IS +Q + I +A A+ + +K + + + E+++E+D + +NM + +
Sbjct: 1738 ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAE---ELKKEQDTSAHLERMKKNMEQTV 1794
Query: 678 AELESALQEQHEV-----NASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRL 732
+L+ L E ++ +Q+ + + E+E+E+ L++ +V L
Sbjct: 1795 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKEL 1854
Query: 733 T-QLEQ---SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQ 788
T Q E+ + L+ + ++ K K Q E +EQ N L AK + LQ + K++
Sbjct: 1855 TYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL-AKFRKLQHELEEAKER 1913
Query: 789 LKDFQNHLNHVVDGLVRPEEVAARV 813
++ +N + V+ EV +V
Sbjct: 1914 ADIAESQVNKL---RVKSREVHTKV 1935
Score = 42.4 bits (98), Expect = 0.005
Identities = 77/369 (20%), Positives = 159/369 (43%), Gaps = 46/369 (12%)
Query: 128 EVLNLSYNLIGKIEKLDKLL--KLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIP 185
E+ L N + +E + L ++R N + K+EG N +Q + H
Sbjct: 1586 ELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ--------LNHAN 1637
Query: 186 VWLGKKLKSLRVLNLKGN-KISSLQDISKLKPLQDLIS-LILVENPVVTLPHYLQFTIFH 243
+ L++LR N +G K + L ++ DL L +VE + +Q +
Sbjct: 1638 RQAAEALRNLR--NTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRA----NLMQAEVEE 1691
Query: 244 LR-SLESLE-GQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETE--ELKSKQTRFLEE 299
LR SLE E G+ + Q+ +A ER L + KK +ET+ +++ + ++E
Sbjct: 1692 LRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQE 1751
Query: 300 IKN-QDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL--LKQKTIELTRACQKQYELEQEL 356
+N ++K K++ + AM+ EELK + +T L +K+ + + Q + + ++L
Sbjct: 1752 ARNAEEKAKKAITDAAMM----AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL 1807
Query: 357 AF-------YKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESY------ 403
A K++A+ L + + + + R K + TE
Sbjct: 1808 ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILR 1867
Query: 404 ---IIDSAQA-VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDE 459
++D Q V+ K + +E ++NL L +LE+ +++ A++++++L +
Sbjct: 1868 LQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVK 1927
Query: 460 IEKAEQQIL 468
+ +++
Sbjct: 1928 SREVHTKVI 1936
Score = 37.0 bits (84), Expect = 0.23
Identities = 46/218 (21%), Positives = 100/218 (45%), Gaps = 34/218 (15%)
Query: 1321 LENEVSRL----EDIMQHLKSKKREERW------MRASKRQSEKE----MEELHHNIDDL 1366
LE ++S++ EDI+Q ++ + + + M A + + E++ +E + N++
Sbjct: 1734 LETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1793
Query: 1367 LQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI----- 1421
+++ + E E+L K+Q QK ++ V L E E+E KH+ + V +
Sbjct: 1794 VKDLQLRLDEAEQLALKGGKKQIQK--LEARVREL--ESEVESEQKHNVEAVKGLRKHER 1849
Query: 1422 ---ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE 1478
E +T R++ LR D L+ + ++++ K + + A E+ + + + E
Sbjct: 1850 RVKELTYQTEEDRKNILRLQD-LVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908
Query: 1479 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
E + RA A+ Q+ L+ ++++ I +E
Sbjct: 1909 EAKERAD-------IAESQVNKLRVKSREVHTKVISEE 1939
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 169 bits (428), Expect = 3e-41
Identities = 216/1065 (20%), Positives = 468/1065 (43%), Gaps = 120/1065 (11%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + L+ ++ + A KR+ E E EL +IDDL +E E V+
Sbjct: 919 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE-------KTLLKRRSELRE 1437
++ +D + L E +K+L+ H+ +D+++ E K+ +K ++ +
Sbjct: 979 NLTEEMAGLDEIIAKLTKE---KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDD 1035
Query: 1438 ADRLLAEAESELSCTKEKTKNAVE---KFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
+ L E E ++ E+ K +E K T + S++ E+D +LE + ++ ++ +
Sbjct: 1036 LEGSL-EQEKKVRMDLERAKRKLEGDLKLT--QESIMDLENDKLQLEEKLKKKEFDINQQ 1092
Query: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI 1554
+ ++ Q A L++ + + ++E+ + + A+ + + K + L+ EL+++ + +
Sbjct: 1093 NSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152
Query: 1555 EMAERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQ 1592
E A +++ K+ E Q R +LE+ L Q+ +
Sbjct: 1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1212
Query: 1593 QQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649
Q+ L+++ K EL + +M ++AKA+L++ R E + E + E + L
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Query: 1650 EELSFQK-------GELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
+ + Q+ GEL Q+ E++ +QLT K ++ E+L+ L + K K L
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332
Query: 1700 NILDMLQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQ 1750
+ L Q H+ L+ Q++ QRV ++VA K E + +Q+ + +
Sbjct: 1333 HAL---QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1389
Query: 1751 KGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD-------IWEKKL 1803
+ + + ++L + ++ +E + A+ +L+ L E EDL + +KK
Sbjct: 1390 EAKKKLAQRLQDAEEA-VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Query: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
++LA ++ + QS LE + R L EL L N + L+ +
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTEL-------FKLKNAYEESLEHLETFK 1501
Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
+LQEE++++ + L +++ K + L E+ LQ + E E
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE---------AEAS 1552
Query: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV-----TLKEQQHQL 1978
+ ++ ++L+ ++E N++K E+ + +K+ E E++K +V T + + +
Sbjct: 1553 LEHEEGKILRAQLEFNQIKA---EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Query: 1979 EKELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
E+ K K++ L+++ + R E ++ +SL+ L T+ QL + + +
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669
Query: 2038 SGELLALQKEADSMRADFSLLR---NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ 2094
+ +++ + ++A+ LR Q RK AE+++ E +++ SQ + ++
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729
Query: 2095 KQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
K+ S + + + +E Q+ + K + ELKK+ LER + +
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 2155 DAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEG 2214
++ L+ + + + +LK + L +L A R LEGELE+ ++ ++ +G
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEA-------RVRELEGELEAEQKRNAESV-KG 1841
Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
+ + ++ E + LR L+ D+L+ +++ +QAE + + Q L
Sbjct: 1842 MRKSERRIKELTYQTEEDKKNLLR--LQDLVDKLQLKVK-AYKRQAE---EAEEQANTNL 1895
Query: 2275 HSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQE 2319
R+ L E A+ + + SQ+ + +G Q+
Sbjct: 1896 SKFRKVQHELDE------AEERADIAESQVNKLRAKSRDIGAKQK 1934
Score = 157 bits (398), Expect = 9e-38
Identities = 218/1025 (21%), Positives = 445/1025 (43%), Gaps = 122/1025 (11%)
Query: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
++ L+ E EK + + +E I++TL K + +E + + E + + + +
Sbjct: 838 IKPLLKSAETEKEMA---TMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894
Query: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
+ DA+ Q + +LE + +E L ++ L A + LE + ++
Sbjct: 895 AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK 954
Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEE----------LQKLQKDIEMAERNEDHHLQV 1567
+ ++ +A + + K + LTEE L K +K ++ A + LQV
Sbjct: 955 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQV 1014
Query: 1568 LKESEVLLQAKRAELEK----LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
++ L + +LE+ L+ + +++ L+R + +L L Q S++ + D
Sbjct: 1015 EEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1074
Query: 1624 ---LQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQL---TLIKQEI 1677
L+E L+ E ++ ++ + I + + L +L + E +I E + +L + ++
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Query: 1678 EKEEENLQVVLRQMSKHKTELKNILDM-----------LQLENHELQGLKLQHDQRVSEL 1726
EK +L L ++S+ E + Q +L+ LQH+ + L
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 1727 EKTQV-AVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECL 1785
K +V E +++NLQ++ Q+ + E K E++ +T+ + L
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKE-------KSEFKLELDDVTSNMEQIIKAKANL 1247
Query: 1786 SKEKEDLQEKCDIWEKKLAQTKRVL-AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
K L+++ + + KL + +R L + +K++ N E L + + + + QL R
Sbjct: 1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE-LARQLEEKEALISQLTRG 1306
Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
KLS + +++QL+E+ +A N+L L + + +L ++ T+ + L ++
Sbjct: 1307 KLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1366
Query: 1905 QKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
++++W ++E Q+ EE ++ Q+LQ + +E K E RLQ E
Sbjct: 1367 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Query: 1957 RESEESKLETSK---VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE---- 2009
E +E S L ++Q +K L + K K ++ S++ ++++ R+L E
Sbjct: 1427 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486
Query: 2010 -ERWCESLE--KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 2066
+ ESLE +T + + L E L E+ GE E + +R + + + +
Sbjct: 1487 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSAL 1546
Query: 2067 KKAEKQVASLK-EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA------ 2119
++AE ASL+ E KI R+QLE N ++ + E +K+ + A+ NH+R
Sbjct: 1547 EEAE---ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ--AKRNHQRVVDSLQT 1601
Query: 2120 ----------------RRLMKELNQMQYEYT-------ELKKQMAN-QKDLERRQMEISD 2155
+++ +LN+M+ + + E +KQ+ + Q L+ Q+++ D
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661
Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NLPF 2209
A+R ++K+ I + N EL +L A++E+ E E EL E L
Sbjct: 1662 AVRA-NDDLKENIAIVERRNNLLQAEL-EELRAVVEQTERSRKLAEQELIETSERVQLLH 1719
Query: 2210 TMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAEV- 2262
+ N +K + EA++E R+ E++ K A + + K+ +
Sbjct: 1720 SQNTSLINQKKKMESDLTQLQSEVEEAVQE-CRNAEEKAKKAITDAAMMAEELKKEQDTS 1778
Query: 2263 --LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQE 2319
L + K+ E T+ L+ ++D ++ A L +LE+ + E + +L Q+
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQI-----ALKGGKKQLQKLEARVRELEGELEAEQK 1833
Query: 2320 KNASA 2324
+NA +
Sbjct: 1834 RNAES 1838
Score = 140 bits (354), Expect = 1e-32
Identities = 178/843 (21%), Positives = 371/843 (44%), Gaps = 105/843 (12%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDL-------LQEKKSL 1373
L+ +R+E++ + L++++ + + +E+EE+ +++ ++ K
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1169
Query: 1374 ECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSLKHHE 1415
E E +++ R +++ R++ D + N++ + +LE EKS E
Sbjct: 1170 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1229
Query: 1416 DIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTES 1475
+D++ + ++K ++ L + R L + +E E+ + ++ FT +R+ LQTE+
Sbjct: 1230 --LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT-TQRAKLQTEN 1286
Query: 1476 DAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS---D 1532
EL R+ +E + Q R + + +E K + EE K N + A S D
Sbjct: 1287 G--ELARQLEEKEALI---SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHD 1341
Query: 1533 FQCLSKKKEKLTEELQKLQK-----DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKS 1587
L ++ E+ TE +LQ+ + E+A+ + ++ +E L +AK+ KL
Sbjct: 1342 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK----KLAQ 1397
Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH---IRE 1644
++ ++ + ++ + ++ H LQ + D++ + ++ N + E
Sbjct: 1398 RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1457
Query: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDM 1704
K EE + + T+L +K E+ E+L+ R+ + E+ ++ +
Sbjct: 1458 WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
Query: 1705 L---QLENHELQGLKLQHD----QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757
L HEL+ ++ Q + + S LE+ + ++ E+ ++ Q Q K EIE
Sbjct: 1518 LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-- 1575
Query: 1758 KQLLERD------KREIER--------MTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
++L E+D KR +R + AE+R+ + K + DL E E +L
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNE----MEIQL 1631
Query: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
+ R+ A A++ K QS L+ ++ + + D L + + + +Q +L+E R
Sbjct: 1632 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1691
Query: 1864 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEE 1923
V + LA+Q+L+ T++ +L S+ T L + + Q E E
Sbjct: 1692 AVVEQTERS-------RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVE 1744
Query: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSKVTLKEQQHQLEK 1980
+ +Q +N E+ K + MM + L+KE+++ E + + T+K+ QH+L++
Sbjct: 1745 ---EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
Query: 1981 ----ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVE 2036
L K +L ++ ++V E + E++R ES+ K + +++R++ E Q E
Sbjct: 1802 AEQIALKGGKKQLQKLEARVRELEGELEA--EQKRNAESV-KGMRKSERRIKELTYQTEE 1858
Query: 2037 KSGELLALQKEADSMRADFSLLRNQF----------LTERKKAEKQVASLKEALKIQRSQ 2086
LL LQ D ++ + Q L++ +K + ++ +E I SQ
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1918
Query: 2087 LEK 2089
+ K
Sbjct: 1919 VNK 1921
Score = 117 bits (294), Expect = 1e-25
Identities = 194/908 (21%), Positives = 406/908 (44%), Gaps = 116/908 (12%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
EE R++ LEK +EL+ K L+E KN +L +++ + ++ C++L
Sbjct: 856 EEFGRIKETLEKSEARRKELEEKMVSLLQE-KNDLQLQVQAEQDNLNDAEERCDQL---- 910
Query: 329 NTKNEL-LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
KN++ L+ K E+ + + E+ EL K K E E +E+ K D+
Sbjct: 911 -IKNKIQLEAKVKEMNERLEDEEEMNAELTAKK--RKLE------DECSELKKDIDDLE- 960
Query: 388 IGKSRYKRNMFATESYIIDSAQAVQ-----IKKMEPDEQ-LRNDHMNLRGHTPLDTQLED 441
+ ++ ++ ATE+ + + + + I K+ +++ L+ H ++ ED
Sbjct: 961 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE---ED 1017
Query: 442 KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLS 499
K +S ++ +L + D++E + +Q + + ++ + ++ LK E+ DL +
Sbjct: 1018 KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL----EN 1073
Query: 500 GRLQLVNKLRQEALDLELQMEKQKQE---IAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
+LQL KL+++ D+ Q K + E QK++K+ Q I+ L+ + ++A+
Sbjct: 1074 DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE------LEAE 1127
Query: 557 KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEG 616
++ + + + K L L+EI R+ +E ++ ++ + + A + +++DLE
Sbjct: 1128 RTARAK----VEKLRSDLSRELEEISERL-EEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 617 VISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE-RDQLEIVAMDAENMRK 675
+ ++ + + E + D + + Q+L + + E + +L+ V + E + K
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242
Query: 676 ELAELES---ALQEQ-HEVNASLQQTQGDLSAYEAELEARLNLRDAE-ANQLKEELEKVT 730
A LE L++Q +E L++ Q L+ + + A+L + E A QL+E+ ++
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAKLQTENGELARQLEEKEALIS 1301
Query: 731 RLTQ------LEQSALQAELEKERQALKNALGKAQFS--------EEKEQENSELHAKLK 776
+LT+ + L+ +LE+E +A KNAL A S E+ +E +E A+L+
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEEGKA-KNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360
Query: 777 HLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN-IHSPSDV 835
+ L K + Q + D + R EE+ +L ++L+ + +++
Sbjct: 1361 RV-----LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 836 LGKSLADLQKQFSEILA---RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR--QAC 890
L K+ LQ + +++ RS ++R + +A ++K Q E Q
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 891 ERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE-----EKE 945
R+L + K +E ++ +E + +EN EEI LT+ QL E + EK
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLET---FKRENKNLQEEISDLTE-QLGEGGKNVHELEKV 1531
Query: 946 RILAQLRELEKKKKLEDAKS-----QEQVFGLDKELKKLKKAVATSDKLATAELTIAK-- 998
R ++ +LE + LE+A++ + ++ E ++K + E+ AK
Sbjct: 1532 RKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1591
Query: 999 -----DQLKS-------LHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELL 1046
D L++ V+++ ++ +L E E + + A R A+ +++ L
Sbjct: 1592 HQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME---IQLSHANRMAAEAQKQVKSL 1648
Query: 1047 QNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNK 1106
Q+LL K Q +L+ + + +E+ N ++ E+ L+ V++ T K
Sbjct: 1649 QSLL--KDTQIQLD-DAVRANDDLKENIAIVERRNNLLQ---AELEELRAVVEQTERSRK 1702
Query: 1107 GGFENVLE 1114
+ ++E
Sbjct: 1703 LAEQELIE 1710
Score = 106 bits (265), Expect = 2e-22
Identities = 187/904 (20%), Positives = 380/904 (42%), Gaps = 129/904 (14%)
Query: 273 ERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKN 332
ER ++ ++ K+ +L++K E +++++++N L + + C ELK D++
Sbjct: 905 ERCDQLIKNKI----QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE 960
Query: 333 ELLKQKTIELTRACQKQYELEQELA-----FYKIDAKFEPL-NYYPSEYAEIDKAPDESP 386
L + E K L +E+A K+ + + L + ++ D+
Sbjct: 961 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN 1020
Query: 387 YIGKSRYKRNMFATE-SYIIDSAQAVQI------KKMEPDEQLRNDH-MNLRG-HTPLDT 437
+ KS+ K + ++ + V++ +K+E D +L + M+L L+
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
+L+ KE I+ +++ + + ++++ ++LEE ++ ++ + A + L
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 498 LSGRLQLVNKLRQEALD-LELQMEKQKQEIAGKQKEIKDLQIAI----DSLDSKDPKHSH 552
LS L+ +++ +EA +Q+E K+ A QK +DL+ A + + KH+
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200
Query: 553 MKAQKSGKEQQLDIMNKQYQQLES-------RLDEILSRIAKETEEIKDLEEQLTEGQIA 605
A+ +Q+D + + Q+LE LD++ S + + + +LE+ +
Sbjct: 1201 SVAELG---EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQ 1257
Query: 606 ANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT----------- 654
ANE K LE L ++ T + + E + +EKE L+ +LT
Sbjct: 1258 ANEYRVK-LEEAQRSLNDFT-TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQME 1315
Query: 655 ----EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEA 710
++E+E +A ++ R + L +E+ E A LQ+ LS +E+
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSEVAQ 1372
Query: 711 RLNLRDAEANQLKEELEKV-TRLTQLEQSALQA---------ELEKERQALKN------- 753
+ +A Q EELE+ +L Q Q A +A LEK + L+N
Sbjct: 1373 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV 1432
Query: 754 ----------ALGK---------AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQN 794
AL K A++ ++ E+ SEL + K + + L + ++
Sbjct: 1433 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1492
Query: 795 HLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV---LGKSLADLQKQFSEIL 851
L H+ + + + +L +LG G N+H V L +LQ E
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTE--QLGEGGKNVHELEKVRKQLEVEKLELQSALEE-- 1548
Query: 852 ARSKWERDEAQVRERKLQ--EEMALQQEKLATGQEEFRQACER------ALEARMNFD-- 901
A + E +E ++ +L+ + A + KLA EE QA +L+ ++ +
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608
Query: 902 --------KRQHEARIQQMENEIHY-------LQENLKSMEEIQGLTDLQLQEADEEKER 946
K++ E + +ME ++ + Q+ +KS++ + T +QL +A +
Sbjct: 1609 SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668
Query: 947 ILAQLRELEKKKKLEDAKSQE--QVFGLDKELKKL--KKAVATSDK--LATAELTIAKDQ 1000
+ + +E++ L A+ +E V + +KL ++ + TS++ L ++ T +Q
Sbjct: 1669 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1728
Query: 1001 LKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLE 1060
K + + ++ E E +QE KA +A D E++ Q+ E+ +
Sbjct: 1729 KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKN 1787
Query: 1061 MEKT 1064
ME+T
Sbjct: 1788 MEQT 1791
Score = 86.3 bits (212), Expect = 3e-16
Identities = 120/571 (21%), Positives = 245/571 (42%), Gaps = 56/571 (9%)
Query: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
K + + + + +++ + + ++ E+R E+ ++ +E DL+ Q+ Q N+
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 609 ALKK---------DLEGVISGLQEYL-------GTIKGQATQAQNECRKLRDEKETLLQR 652
A ++ LE + + E L + + + ++EC +L+ + + L
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 653 LTEVEQERDQLEIVAMDAENMRKELAELESAL----QEQHEVNASLQQTQGDLSAYEAEL 708
L +VE+E+ E +N+ +E+A L+ + +E+ + + QQ DL E ++
Sbjct: 963 LAKVEKEKHATE---NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKV 1019
Query: 709 EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFS-EEKEQE 767
+ L+ + Q ++LE ++ ++ +LE+ ++ L+ L Q S + E +
Sbjct: 1020 NS-LSKSKVKLEQQVDDLEGSLE----QEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1074
Query: 768 NSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKL-GTGE 826
+L KLK + D N +++D Q + L +E AR++EL +L+ T
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL---KENQARIEELEEELEAERTAR 1131
Query: 827 MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
+ L + L ++ ++ E + + + + RE + Q+ +E AT Q E
Sbjct: 1132 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE--ATLQHEA 1189
Query: 887 RQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKER 946
A R ++H + ++ +I LQ + +E+ + L+L + E+
Sbjct: 1190 TAAALR----------KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 947 ILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
I+ LEK + + ++ E L++ + L KL T +A+ QL+
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELAR-QLEEKEA 1298
Query: 1007 TVMKINQERAEELQEAERFSR------KAAQA-ARDLTRAEAEIELLQNLLRQKGEQFRL 1059
+ ++ + + Q+ E R KA A A L A + +LL+ Q E+
Sbjct: 1299 LISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR---EQYEEETEA 1355
Query: 1060 EMEKTGVGTGANSQVLEIEKLNETMERQRTE 1090
+ E V + ANS+V + ET QRTE
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386
Score = 84.0 bits (206), Expect = 2e-15
Identities = 126/575 (21%), Positives = 246/575 (42%), Gaps = 105/575 (18%)
Query: 613 DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE----VEQERDQLEIVAM 668
+ E ++ ++E G IK +++ ++L ++ +LLQ + V+ E+D L
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE-----ARLNLRDAEANQLK 723
+ + K +LE+ ++E +E ++ +L+A + +LE + ++ D E K
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 724 EELEK------VTRLTQLEQSALQ---AELEKERQALKNALGKA--QFSEEKEQENSELH 772
E EK V LT+ E + L A+L KE++AL+ A +A E+++ NS
Sbjct: 966 VEKEKHATENKVKNLTE-EMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024
Query: 773 AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSP 832
+K+K L+QQ+ D + L +E R+D R K KL G++ +
Sbjct: 1025 SKVK--------LEQQVDDLEGSLE---------QEKKVRMDLERAKRKL-EGDLKLTQ- 1065
Query: 833 SDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACER 892
+S+ DL+ KLQ E L++++ Q+ + E+
Sbjct: 1066 -----ESIMDLEND--------------------KLQLEEKLKKKEFDINQQNSKIEDEQ 1100
Query: 893 ALEARMNFDKRQHEARIQQMENEI------------------HYLQENLKSMEEIQGLTD 934
L ++ ++++ARI+++E E+ L+E + +EE G T
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160
Query: 935 LQLQEADEEKERILAQLRELEK------------KKKLEDAKSQ--EQVFGLDKELKKLK 980
+Q++ + + R+LE+ +KK D+ ++ EQ+ L + +KL+
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220
Query: 981 KAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE 1040
K + KL ++T +Q+ + K+++ ++ E +A ++ D T
Sbjct: 1221 KE-KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279
Query: 1041 AEIELLQ-NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
A+++ L RQ E+ L + T G S ++E L +E + L + L
Sbjct: 1280 AKLQTENGELARQLEEKEALISQLT---RGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336
Query: 1100 LTGSD---NKGGFENVLEEIAELRREVSYQNDYIS 1131
D + +E E AEL+R +S N ++
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Score = 78.6 bits (192), Expect = 7e-14
Identities = 115/590 (19%), Positives = 253/590 (42%), Gaps = 88/590 (14%)
Query: 258 QDRQEAFERF-----SLEEVE-RLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLK 311
QD +EA E SLE+ + RL+ ++E M++ E + ++ +N DK+ L
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI---LA 1456
Query: 312 EEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYY 371
E KQ EE +S+L + + + + EL + E + L +K + K
Sbjct: 1457 E----WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK------- 1505
Query: 372 PSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRG 431
+ EI ++ GK+ ++ + ++++K+E L
Sbjct: 1506 -NLQEEISDLTEQLGEGGKNVHELEKVRKQ---------LEVEKLELQSALEE------- 1548
Query: 432 HTPLDTQLEDKEKKISAAQTRLSELHDEIEKA----EQQILRATEEFKQLEEAIQLKKIS 487
+ LE +E KI AQ +++ EIE+ ++++ +A +++ +++Q +
Sbjct: 1549 ---AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDA 1605
Query: 488 EAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKD 547
E + + L++ K+ + ++E+Q+ + A QK++K LQ + D++
Sbjct: 1606 ET------RSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK--DTQI 1657
Query: 548 PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
++A KE + I+ ++ L++ L+E L + ++TE + L EQ
Sbjct: 1658 QLDDAVRANDDLKEN-IAIVERRNNLLQAELEE-LRAVVEQTERSRKLAEQ--------- 1706
Query: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
+ E + + Q T N+ +K+ + L Q +EVE+ +
Sbjct: 1707 ---------ELIETSERVQLLHSQNTSLINQKKKMESD---LTQLQSEVEEAVQECRNAE 1754
Query: 668 MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQL----- 722
A+ + A + L+++ + +A L++ + ++ +L+ RL+ EA Q+
Sbjct: 1755 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD----EAEQIALKGG 1810
Query: 723 KEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
K++L+K+ + + L+AE ++ +++K + +E + E L LQD
Sbjct: 1811 KKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLV 1870
Query: 783 NLLKQQLKDFQNHLNHVVD----GLVRPEEVAARVDELRRKLKLGTGEMN 828
+ L+ ++K ++ + L + +V +DE + + ++N
Sbjct: 1871 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
Score = 63.2 bits (152), Expect = 3e-09
Identities = 101/503 (20%), Positives = 218/503 (43%), Gaps = 91/503 (18%)
Query: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEE-AMLQKQSCEELKS 326
S E+E +++ E +LK+ LE ++ + NK+L+EE + L +Q E K+
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524
Query: 327 --DLNTKNELLKQKTIELTRACQK-----QYE----LEQELAFYKIDAKFEPLNYYPSEY 375
+L + L+ + +EL A ++ ++E L +L F +I A+ E +
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE------RKL 1578
Query: 376 AEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH--- 432
AE D+ +++ KRN ++DS Q ++ + + RN+ + ++
Sbjct: 1579 AEKDEEMEQA--------KRN----HQRVVDSLQT----SLDAETRSRNEVLRVKKKMEG 1622
Query: 433 --TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI---LRATEEFK------------ 475
++ QL + + AQ ++ L ++ + Q+ +RA ++ K
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682
Query: 476 ---QLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKE 532
+LEE + + +E + L ++L + V L + L Q +K + ++ Q E
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742
Query: 533 IKDLQIAIDSLDSKDPK---HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
+++ + + K K + M A++ KEQ L R+ K
Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH--------------LERMKKNM 1788
Query: 590 EE-IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
E+ IKDL+ +L E + A + KK L+ + + ++E G ++ + + + +R +
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848
Query: 649 LLQRLTEVEQER-------DQLEIVAMDAENMRKELAELESALQEQHEVNAS-LQQTQGD 700
+ + + E+++ D ++ + + + +++ E E EQ N S ++ Q +
Sbjct: 1849 IKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAE----EQANTNLSKFRKVQHE 1904
Query: 701 LSAYEAELEARLNLRDAEANQLK 723
L E E R ++ +++ N+L+
Sbjct: 1905 LD----EAEERADIAESQVNKLR 1923
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 168 bits (425), Expect = 6e-41
Identities = 201/944 (21%), Positives = 415/944 (43%), Gaps = 97/944 (10%)
Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL-------QEKKSLECEVEE 1379
+++++ + L+ ++ + A +R+ E E EL +IDDL +EK++ E +V+
Sbjct: 967 KVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKN 1026
Query: 1380 L-------HRTVQKRQQQKDFIDGNVESLMTELEIE--------KSLKHHEDIVDEIECI 1424
L +V + ++K + + + +L+ E K+ E V+++EC
Sbjct: 1027 LTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECS 1086
Query: 1425 EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
+ K R + A R L E +L T+E +A + + L + +S+ +L R
Sbjct: 1087 LEQEKKLRMDTERAKRKL---EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRV 1143
Query: 1485 QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE--- 1541
++ + + ++++ LQA A++LE+ + + K A + + LS++ E
Sbjct: 1144 EDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAG 1203
Query: 1542 -----------KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590
K EL +L++++E A + + L+ QA+ A +L QV
Sbjct: 1204 GASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRK----QAEGAA--ELGEQVD 1257
Query: 1591 SQQQEMAVLDRQLGHKKEELHLLQGS---MVQAKADLQEALRLGETEVTEKCNHIREVKS 1647
S Q+ L+++ + E+ L + + +AKA ++ R E +++E + E++
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQR 1317
Query: 1648 LLEELSFQKGELNVQISERK----------TQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
L + S Q+G L + E +QL+ K + E L+ L + SK K+
Sbjct: 1318 QLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSA 1377
Query: 1698 LKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757
L + + L+ H+ L+ QH++ + ++ L K E Q S+ + I+
Sbjct: 1378 LAHAVQALR---HDCDLLREQHEEEAEA--QAELQRLLSKANAEVAQWRSKYEADAIQRT 1432
Query: 1758 KQLLERDKREIERMTAESRALQSC-VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEEN 1816
++L E K+ R+ +++ +C S EK L+ + + + L + AAA +
Sbjct: 1433 EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALD 1492
Query: 1817 SKME--QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSL----- 1869
K + LE+ ++Q+EL+ R+ L ++ ++ +E EA+ +L
Sbjct: 1493 KKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENK 1552
Query: 1870 --QEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQ 1927
QEE++++ D ++L+ + + K + L E++ +Q + E E +E +T +
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE--LEETKTLRI 1610
Query: 1928 QLQVLQNEIE-ENKLKLVQQEMMFQRLQKER--ESEESKLETSKVTLKEQ---QHQLEKE 1981
QL++ Q + E + KL +E R +R ES ++ L+ E + ++E +
Sbjct: 1611 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 1670
Query: 1982 LTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGEL 2041
L D + +L + A+ R +Q + L + + E ++ E +
Sbjct: 1671 LNDLELQLGHATRQATEAQAATRLMQAQ----------LKEEQAGRDEEQRLAAELHEQA 1720
Query: 2042 LALQKEADSMRADFSLLR---NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
AL++ A + A+ LR Q R+ AE+++ E L + SQ L ++K+
Sbjct: 1721 QALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1780
Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMR 2158
+ + + +E AQ+ E + K + ELKK+ LER + + +R
Sbjct: 1781 ADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVR 1840
Query: 2159 TLKSEVKDEIRTSLKNLNQFLPELPA---DLEAILERNENLEGE 2199
L++ +++ + +L+ + + +L A +LEA L+ + E
Sbjct: 1841 ELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884
Score = 146 bits (369), Expect = 2e-34
Identities = 232/1047 (22%), Positives = 445/1047 (42%), Gaps = 135/1047 (12%)
Query: 1333 QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV-----------EELH 1381
+ L + + E R +R + +E + +EL + QEK L ++ E H
Sbjct: 896 EELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCH 955
Query: 1382 RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
++ + Q ++G V+ L LE E+ + + D+ +E + + ++ +
Sbjct: 956 LLIKSKVQ----LEGKVKELSERLEDEEEV--NADLAARRRKLEDECTELKKDIDDLKLT 1009
Query: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL---------- 1491
LA+AE E T+ K KN E+ S+ + + + L+ Q+ +L
Sbjct: 1010 LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSAL 1069
Query: 1492 ----VKADQQLRSLQADAK-------DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKK 1540
++ +QQ+ L+ + D E+ K K E LK + VA D Q L +K
Sbjct: 1070 TKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKL 1129
Query: 1541 EKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD 1600
+K EL +L +E + + +KE + + ELE ++ +++ A
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189
Query: 1601 RQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV----KSLLEELSFQK 1656
R+L E L G A A +E R E E+ + E ++ + L ++
Sbjct: 1190 RELEELSERLEEAGG----ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQ 1245
Query: 1657 GELNVQISERKTQLTLIKQEIEKEEENLQVV-------LRQMSKHKTELKNILDMLQLEN 1709
E ++ E+ L ++Q++EKE+ L++ + +++ K + + + +
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 1710 HELQGLKLQHDQRVSELEKTQVAVLE-EKLELENLQQ-----ISQQQKGEIEWQKQLLER 1763
E + +K++ QR TQ L+ E EL L + ISQ +G+ Q LE
Sbjct: 1306 SEAK-IKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGK-ALAAQSLEE 1363
Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
+R++E + AL V+ L + + L+E+ + + A+ +R+L+ A N+++ Q
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKA--NAEVAQWR 1421
Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
K E + + +EL++ + KL+L Q+ +E EA N+ L + L
Sbjct: 1422 -SKYEADAIQRTEELEEAKK-KLALR------LQEAEEGVEAANAKCSSLEKAKLRLQTE 1473
Query: 1884 KQD----LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1939
+D L T L +Q L++ + E + E+ Q+E E Q++ + L E+
Sbjct: 1474 SEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533
Query: 1940 KLKLVQQEMMFQRLQKERESEESKLE--TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVL 1997
+ + + L++E ++ + ++ T +V+L + Q EL K L+ S++
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQ---ELEKTKKALEGEKSEIQ 1590
Query: 1998 AA-EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLAL----QKEADSMR 2052
AA EE L+ EE ++ LSQ K +E +++L EK E L Q+ +S++
Sbjct: 1591 AALEEAEGALELEETKTLRIQLELSQVK---AEVDRKLAEKDEECANLRRNHQRAVESLQ 1647
Query: 2053 ADF---SLLRNQFLTERKKAE--------------KQVASLKEALKIQRSQLEKNLLEQK 2095
A + RN+ L +KK E +Q + A ++ ++QL++ +
Sbjct: 1648 ASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRD 1707
Query: 2096 QENSCIQKEMATIELVAQDNHERARRLMKELNQMQ--YEYTELKKQMANQKDLE-RRQME 2152
+E Q+ A + AQ RA L EL +++ E E +++A Q+ LE ++
Sbjct: 1708 EE----QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLN 1763
Query: 2153 ISDAMRTLKSEVKDEIRTSLKNLNQFLPEL-----------------PADLEAILERNEN 2195
+ + T K ++ L L+ + E A + L++ ++
Sbjct: 1764 LLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD 1823
Query: 2196 LEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHC 2255
LE +K+ L T+ E + +L ++ + G+ +KL + L+A+L
Sbjct: 1824 TSAHLERMKKTLEQTVRE--LQARLEEAEQAALR---GGKKQVQKLEAKVRELEAELDAE 1878
Query: 2256 MSKQAEVLIKGKRQTEGTLHSLRRQVD 2282
K AE L KG R+ E + L Q +
Sbjct: 1879 QKKHAEAL-KGVRKHERRVKELAYQAE 1904
Score = 135 bits (341), Expect = 4e-31
Identities = 204/972 (20%), Positives = 425/972 (43%), Gaps = 115/972 (11%)
Query: 1425 EKTLLKRRSELREADRLLAEAESE--------LSCTKEKTKNAVE------KFTDAK--- 1467
E+ L R+ELR LA AE++ +S T+EK A++ DA+
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954
Query: 1468 ----RSLLQTESDAEELERRAQET-------AVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
+S +Q E +EL R ++ A K + + L+ D DL+ K E
Sbjct: 955 HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAE 1014
Query: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMA---ERNEDHHLQVLKESEV 1573
+ + V + L + +LT+E + LQ+ + A + E+ + L ++++
Sbjct: 1015 KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL 1074
Query: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE--LHLLQGSMVQAKADLQEALRLG 1631
L+ + +LE + +Q++ +D + +K E L L Q S+ A D Q+
Sbjct: 1075 RLEQQVEDLE-----CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL---- 1125
Query: 1632 ETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQM 1691
E ++ +K + + ++ +E+ ++ +I E + + +++E+E E V +Q
Sbjct: 1126 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR 1185
Query: 1692 SKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQIS 1747
++ EL+ + + L+ G + +R +EL + + A L + + L++
Sbjct: 1186 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQ 1245
Query: 1748 QQQKGEIEWQKQLLERDKREIERMTAESRA----LQSCVECLSKEKEDLQEKCDIWEKKL 1803
+ E+ Q L+R ++++E+ +E R L + VE L++ K ++ C +E +L
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 1804 AQTK-------RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
++ K R LA A Q+ +L + + + + QL+R K + ++
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
+QL+E+ +A ++L + ++ +L ++ + Q L ++ ++++W +++E
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425
Query: 1917 --DCQKEEETKQQ------QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE--- 1965
Q+ EE ++ +LQ + +E K E RLQ E E +LE
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485
Query: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE--------ERWCESLE 2017
++ L ++Q LE+ L +++ + +++ ++ AA+ R L E E E+LE
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545
Query: 2018 KTLSQTKRQLSEREQQLVEK---SGE-LLALQKEADSMRADFSLLRNQFLTERKKAEKQV 2073
TL + + L E L ++ SG+ + L+K ++ + S + + E +
Sbjct: 1546 -TLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEI------QAALEEAEG 1598
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA-RRLMKELN---QM 2129
A E K R QLE + ++ + + +K+ L + NH+RA L L+ +
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANL--RRNHQRAVESLQASLDAETRA 1656
Query: 2130 QYEYTELKKQM-ANQKDLE-------RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPE 2181
+ E LKK+M + DLE R+ E A R +++++K+E + + E
Sbjct: 1657 RNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE-QAGRDEEQRLAAE 1715
Query: 2182 LPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK- 2240
L +A+ R L ELE L+ + +G E ++ +++ R L +
Sbjct: 1716 LHEQAQALERRASLLAAELEELRA----ALEQG--ERSRRLAEQELLEATERLNLLHSQN 1769
Query: 2241 --LRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASS 2298
L +++ +L+A L +S + E + +R+ E ++ + + + +S
Sbjct: 1770 TGLLNQKKKLEADLAQ-LSGEVEEAAQERREAE---EKAKKAITDAAMMAEELKKEQDTS 1825
Query: 2299 PSLSQLESSLTE 2310
L +++ +L +
Sbjct: 1826 AHLERMKKTLEQ 1837
Score = 123 bits (308), Expect = 2e-27
Identities = 165/792 (20%), Positives = 339/792 (42%), Gaps = 103/792 (13%)
Query: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
E E+ RL ++ ++ R E + A +R+ + EL +D L + ++ LE E EL
Sbjct: 1217 EAELGRLRRELE--EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274
Query: 1382 RTVQKRQQQKDFIDGNVESLM-TELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
V D + NVE+L + EK + +ED + E + + L ++ ++
Sbjct: 1275 MEV-------DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRG 1327
Query: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
L ELS E+ + + + + K Q+ EEL R+ +E + +++
Sbjct: 1328 RLQTESGELSRLLEEKECLISQLSRGKALAAQS---LEELRRQLEEESKAKSALAHAVQA 1384
Query: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE----KLTEELQKLQKDIEM 1556
L+ D L + ++ E E+ ++++ +++ K E + TEEL++ +K + +
Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLAL 1444
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEM-----------AVLDRQLGH 1605
LQ +E AK + LEK K ++ ++ +++ A LD++ H
Sbjct: 1445 -------RLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRH 1497
Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGE---TEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
+ L + + + +L+ A R TE+ + E LE L + L +
Sbjct: 1498 LERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEE 1557
Query: 1663 ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQR 1722
IS+ Q++L + I++ E+ + + + S+ + L+ L+LE + ++L+ Q
Sbjct: 1558 ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQV 1617
Query: 1723 VSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV 1782
+E+++ + E+ E NL++ Q+ ++ + AE+RA +
Sbjct: 1618 KAEVDRK---LAEKDEECANLRRNHQRAVESLQ-------------ASLDAETRARNEAL 1661
Query: 1783 ECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN 1842
K + DL + E +L R A+ +++ Q+ L++ + + Q+ +L+
Sbjct: 1662 RLKKKMEGDLNDL----ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH 1717
Query: 1843 RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT 1902
+L S + +L+E R A+ + LA+Q+LL T+ ++L S+ T
Sbjct: 1718 EQAQALERRASLLAAELEELRAALEQGERSR-------RLAEQELLEATERLNLLHSQNT 1770
Query: 1903 -------RLQKDISEWANRFEDCQKEEETKQQQLQ-------VLQNEIEENKLKLVQQEM 1948
+L+ D+++ + E+ +E +++ + ++ E+++ + E
Sbjct: 1771 GLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1830
Query: 1949 MFQRLQKERESEESKLETSKVT-----------LKEQQHQLEKELTDQKSKLDQVLSKVL 1997
M + L++ +++LE ++ L+ + +LE EL ++ K + L V
Sbjct: 1831 MKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR 1890
Query: 1998 AAEERVRTLQ---EEER--------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK 2046
E RV+ L EE+R + L+ + KRQ E EQQ + Q
Sbjct: 1891 KHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQH 1950
Query: 2047 EADSM--RADFS 2056
E D RAD +
Sbjct: 1951 ELDDAEERADMA 1962
Score = 122 bits (306), Expect = 4e-27
Identities = 195/893 (21%), Positives = 366/893 (40%), Gaps = 163/893 (18%)
Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE-------CEVEE 1379
++ED+ L+ +K+ +KR+ E +++ ++ D Q+K+ LE E+ +
Sbjct: 1079 QVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQ 1138
Query: 1380 LHRTVQKRQ-----QQKDF--IDGNVESLMTELEIEKSL-----KHHEDIVDEIECIEKT 1427
L V+ Q QK + E L ELE E++ K + E+E + +
Sbjct: 1139 LSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSER 1198
Query: 1428 L--------------LKRRSELREADRLLAEA----ESELSCTKEKTKNAV----EKFTD 1465
L KR +EL R L EA E+ ++ + K E+
Sbjct: 1199 LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDS 1258
Query: 1466 AKRSLLQTESDAEELERRAQETAVN---LVKADQQLRSLQADAKD-LEQHKIKQEEILK- 1520
+R + E + EL + A N L +A L +D L + KIK EE+ +
Sbjct: 1259 LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 1318
Query: 1521 ----------------EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED-- 1562
E+++++ K+ LS+ K + L++L++ +E + +
Sbjct: 1319 LADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSAL 1378
Query: 1563 -HHLQVLKESEVLLQAK-------RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQ 1614
H +Q L+ LL+ + +AEL++L S+ ++ + K E +Q
Sbjct: 1379 AHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW--------RSKYEADAIQ 1430
Query: 1615 GSMVQAKADLQEALRLGETE-----VTEKCNHIREVKSLLE------------------E 1651
+ +A + ALRL E E KC+ + + K L+
Sbjct: 1431 RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAA 1490
Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIE---KEEENLQVVLRQMSKHKTELKNILDMLQLE 1708
L ++ L + ER+ Q +++E+E +E L L ++ E L+ L+ E
Sbjct: 1491 LDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRE 1550
Query: 1709 NHELQGLKLQHDQRVS-------ELEKTQVAVLEEKLELENLQQISQQQKG--EIEWQKQ 1759
N LQ +VS ELEKT+ A+ EK E +Q ++ +G E+E K
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSE---IQAALEEAEGALELEETKT 1607
Query: 1760 L-----LERDKREIERMTAE------------SRALQSCVECLSKEKEDLQEKCDIWEK- 1801
L L + K E++R AE RA++S L E E + +K
Sbjct: 1608 LRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKM 1667
Query: 1802 --KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
L + L A + Q+ ++ +++ Q D+ R LH A++++
Sbjct: 1668 EGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRA 1727
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEWA 1912
+ L+ L + LA+Q+LL T+ ++L S+ T +L+ D+++ +
Sbjct: 1728 SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLS 1787
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
E+ +E + E+ K + MM + L+KE+++ + LE K TL+
Sbjct: 1788 GEVEEAAQERREAE----------EKAKKAITDAAMMAEELKKEQDT-SAHLERMKKTLE 1836
Query: 1973 EQQHQLEKELTD-QKSKLDQVLSKVLAAEERVRTLQ-----EEERWCESLEKTLSQTKRQ 2026
+ +L+ L + +++ L +V E +VR L+ E+++ E+L K + + +R+
Sbjct: 1837 QTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL-KGVRKHERR 1895
Query: 2027 LSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
+ E Q E L +Q D +++ + QF ++A +A ++A
Sbjct: 1896 VKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKA 1948
Score = 120 bits (301), Expect = 2e-26
Identities = 172/862 (19%), Positives = 368/862 (42%), Gaps = 88/862 (10%)
Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
EEL + + L++A + R ++ + + L + I I A K+ + L
Sbjct: 823 EELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLF 882
Query: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMA 1597
K + L L+ Q + E+A + L+ L+ + +AKR ELE+ +T ++ ++A
Sbjct: 883 FKMKPL---LRSAQAEEELAALRAE--LRGLRGALAAAEAKRQELEETHVSITQEKNDLA 937
Query: 1598 VL----DRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELS 1653
+ L +E HLL S VQ + ++E ++E+ EV + +L+
Sbjct: 938 LQLQAEQDNLADAEERCHLLIKSKVQLEGKVKE--------LSERLEDEEEVNA---DLA 986
Query: 1654 FQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQ 1713
++ +L + +E K + +K + K E+ Q ++ E+ + + + E +
Sbjct: 987 ARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKK 1046
Query: 1714 GLKLQHDQRVSELEKTQ---VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER 1770
L+ H Q + +L+ + A+ + KL LE QQ+ + + +E +K+L +R +
Sbjct: 1047 ALQEAHQQALGDLQAEEDRVSALTKAKLRLE--QQV-EDLECSLEQEKKLRMDTERAKRK 1103
Query: 1771 MTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELN 1830
+ + + Q V +++K+ L+EK + +L+Q + + Q +++L+
Sbjct: 1104 LEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQAR 1163
Query: 1831 VRKLQQELD-------QLNRDKLSLHNDISAMQQQLQE-------KREAVNSLQEELANV 1876
+L++EL+ ++ + + ++ + ++L+E +RE + EL +
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRL 1223
Query: 1877 QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
+ L A +H+ + + + + + +E + + Q+ + +++ L+ E+
Sbjct: 1224 RRELEEA------ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEV 1277
Query: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV 1996
++ + +K + E +L +K+ ++E Q QL + + Q+ +L
Sbjct: 1278 DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQL-ADASTQRGRLQ------ 1330
Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS 2056
+ E R L+E+E L + + + L E +QL E+S AL ++R D
Sbjct: 1331 TESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCD 1390
Query: 2057 LLRNQFLTERK-KAEKQVASLKEALKIQ--RSQLEKNLLEQKQENSCIQKEMATIELVAQ 2113
LLR Q E + +AE Q K ++ RS+ E + +++ +E +K++A A+
Sbjct: 1391 LLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE 1450
Query: 2114 DNHERAR-----------RLMKELNQMQYEYTEL--------KKQMANQKDLERRQMEIS 2154
+ E A RL E + E KKQ ++ LE R+ +
Sbjct: 1451 EGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEE 1510
Query: 2155 DAMRTLKSEVKDE--IRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMN 2212
+ R L++ ++ + T L L E LE + N+NL+ E+ L + + +
Sbjct: 1511 EMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGK 1570
Query: 2213 EGPFEEKL------NFSQVHIMDEHWRG-----EALREKLRHREDRLKAQLRHCMSKQAE 2261
EK S++ E G E +++ ++KA++ ++++ E
Sbjct: 1571 SIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE 1630
Query: 2262 VLIKGKRQTEGTLHSLRRQVDA 2283
+R + + SL+ +DA
Sbjct: 1631 ECANLRRNHQRAVESLQASLDA 1652
Score = 113 bits (282), Expect = 2e-24
Identities = 212/941 (22%), Positives = 388/941 (41%), Gaps = 190/941 (20%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
++++ L+ L K E + ++K EE+ D+ L +E +++ ++ DL
Sbjct: 1001 KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQ 1060
Query: 330 TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
+ + + LT+A + LEQ++ + + E +E A
Sbjct: 1061 AEED----RVSALTKA---KLRLEQQVEDLECSLEQEKKLRMDTERA------------- 1100
Query: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKE------ 443
K + + ++ T+ + D+AQ K + +E+L+ L + L ++ED++
Sbjct: 1101 KRKLEGDLKLTQESVADAAQ----DKQQLEEKLKKKDSEL---SQLSLRVEDEQLLGAQM 1153
Query: 444 -KKISAAQTRLSELHDEIE-------KAEQQILRATEEFKQLEEAIQLKKISEAGKDLLY 495
KKI Q R EL +E+E + E+Q A E ++L E ++ + AG+
Sbjct: 1154 QKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGC 1213
Query: 496 KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKE-IKDLQIAIDSLDSKDPKHSHMK 554
++ L +LR+E + L+ E + KQ E +L +DSL + K
Sbjct: 1214 RKREAEL---GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL-----QRVRQK 1265
Query: 555 AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDL 614
+K E ++++ L + ++ + A + + E+QL+E +I E L++ L
Sbjct: 1266 LEKEKSELRMEV-----DDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE-LQRQL 1319
Query: 615 EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMR 674
T +G+ E +L +EKE L+ +L+ + + A E +R
Sbjct: 1320 ADA--------STQRGRLQTESGELSRLLEEKECLISQLSRGKA------LAAQSLEELR 1365
Query: 675 KELAELESA-----------------LQEQHEVNASLQ-QTQGDLSAYEAELEARLNLRD 716
++L E A L+EQHE A Q + Q LS AE+ + +
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425
Query: 717 AEANQLKEELEKV-------------------TRLTQLEQSALQAELEKERQALK----- 752
A+A Q EELE+ + + LE++ L+ + E E L+
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485
Query: 753 ---NALGKAQFS-----EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLV 804
AL K Q EE+ ++ E+ +L+ Q ++ L +L F+ H
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTEL--FRLRHGH------ 1537
Query: 805 RPEEVAARVDELRRKLKLGTGEMN-IHSPSDVLGKSLADLQK-------QFSEILARSKW 856
EE ++ L+R+ K E++ + + GKS+ +L+K + SEI A +
Sbjct: 1538 --EEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595
Query: 857 ERDEAQVRERK-LQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENE 915
++ E K L+ ++ L Q K A + + E R N +R E+ ++ E
Sbjct: 1596 AEGALELEETKTLRIQLELSQVK-AEVDRKLAEKDEECANLRRNH-QRAVESLQASLDAE 1653
Query: 916 IHYLQENLKSMEEIQG-LTDLQLQ---------EADEEKERILAQLRELEKKKKLED--- 962
E L+ ++++G L DL+LQ EA + AQL+E + + E
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLA 1713
Query: 963 AKSQEQVFGLDK-------ELKKLKKAVATSDK---LATAELTIAKDQLKSLH------- 1005
A+ EQ L++ EL++L+ A+ ++ LA EL A ++L LH
Sbjct: 1714 AELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1773
Query: 1006 --------------GTVMKINQERAEELQEAERFSRKAAQAARDLTRAE---AEIELLQN 1048
G V + QER E ++A++ AA A +L + + A +E ++
Sbjct: 1774 NQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1833
Query: 1049 LLRQ--KGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQ 1087
L Q + Q RLE + G QV ++E +E +
Sbjct: 1834 TLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874
Score = 113 bits (282), Expect = 2e-24
Identities = 145/690 (21%), Positives = 303/690 (43%), Gaps = 92/690 (13%)
Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK 1386
++E++ + L + ++ + + +EE I L + K +EEL R +++
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 1370
Query: 1387 RQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR------EADR 1440
+ K + V++L + ++ + +H E+ + E +++ L K +E+ EAD
Sbjct: 1371 ESKAKSALAHAVQALRHDCDLLRE-QHEEEAEAQAE-LQRLLSKANAEVAQWRSKYEADA 1428
Query: 1441 L-----LAEAESELSCTKEKTKNAVEKFTDAKRSL------LQTESDAEELE-RRAQETA 1488
+ L EA+ +L+ ++ + VE SL LQTES+ LE RA A
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAA 1488
Query: 1489 VNLVKADQQL---------------RSLQADAKDLE-------------QHKIKQEEILK 1520
L K + L R L+A ++ + ++ E LK
Sbjct: 1489 AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 1548
Query: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
NK + + SD K +EL+K +K +E E++E L+E+E L+ +
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALE-GEKSEIQ--AALEEAEGALELEET 1605
Query: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640
+ +++ +++ Q A +DR+L K EE L+ + +A LQ +L E
Sbjct: 1606 KTLRIQLELS---QVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR 1662
Query: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE---ENLQVVLRQMSKHKTE 1697
++++ L +L Q G Q +E + L++ ++++E+ + Q + ++ +
Sbjct: 1663 LKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQA 1722
Query: 1698 LKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL---ENLQQISQQQKGEI 1754
L+ +L E EL+ L+ +R L + ++ E+L L +N ++Q++K E
Sbjct: 1723 LERRASLLAAELEELRAA-LEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEA 1781
Query: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKEDLQEKCDIWEKKLAQTKRV 1809
+ + E ++ ER AE +A ++ + K+++D + +K L QT R
Sbjct: 1782 DLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRE 1841
Query: 1810 LAAAEENSKME-----QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKRE 1864
L A E ++ + ++KLE VR+L+ ELD + ++ E
Sbjct: 1842 LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDA-----------------EQKKHAE 1884
Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
A+ +++ V++ A++D + + QD++ +LQ + + +FE+ +++ T
Sbjct: 1885 ALKGVRKHERRVKELAYQAEEDRKNLARMQDLV----DKLQSKVKSYKRQFEEAEQQANT 1940
Query: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQ 1954
+ + Q+E+++ + + E +L+
Sbjct: 1941 NLAKYRKAQHELDDAEERADMAETQANKLR 1970
Score = 100 bits (248), Expect = 2e-20
Identities = 184/788 (23%), Positives = 347/788 (44%), Gaps = 120/788 (15%)
Query: 414 KKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEE 473
+++E +E++ D R L+ + + +K I + L++ E + E ++ TEE
Sbjct: 973 ERLEDEEEVNADLAARR--RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEE 1030
Query: 474 FKQLEEAI-----QLKKISEAGKDLL------YKQLSGRLQLVNKLRQEALDLELQMEKQ 522
L+E++ + K + EA + L ++S + +L Q+ DLE +E++
Sbjct: 1031 MAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE 1090
Query: 523 KQ----EIAGKQKEIKDLQIAIDSL--DSKDPKHSHMKAQKSGKE-QQLDIMNKQYQQLE 575
K+ K+K DL++ +S+ ++D + K +K E QL + + Q L
Sbjct: 1091 KKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLG 1150
Query: 576 SRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIK--GQAT 633
+++ + + + EE LEE+L E + AA ++K L+E ++ G A+
Sbjct: 1151 AQMQKKIKELQARAEE---LEEEL-EAERAARARVEKQRAEAARELEELSERLEEAGGAS 1206
Query: 634 QAQNE-CRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
Q E CRK R+ + L+R E R + + A +R++ AE + L EQ +
Sbjct: 1207 AGQREGCRK-REAELGRLRRELEEAALRHEATVAA-----LRRKQAEGAAELGEQVD--- 1257
Query: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALK 752
SLQ+ + L ++EL R+ + D AN +E +TR +A EK + +
Sbjct: 1258 SLQRVRQKLEKEKSEL--RMEVDDLAAN-----VETLTR--------AKASAEKLCRTYE 1302
Query: 753 NALGKAQFS-EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA 811
+ L +A+ EE +++ ++ + LQ ++ L + L++ + ++ L R + +AA
Sbjct: 1303 DQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE----CLISQLSRGKALAA 1358
Query: 812 R-VDELRRKLK--------LGTGEMNIHSPSDVL-------GKSLADLQKQFSEILA--- 852
+ ++ELRR+L+ L + D+L ++ A+LQ+ S+ A
Sbjct: 1359 QSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVA 1418
Query: 853 --RSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQAC------------------ 890
RSK+E D Q E + ++++AL+ ++ G E C
Sbjct: 1419 QWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478
Query: 891 ---ERALEARMNFDKRQH--EARIQQMENEIHYLQENLKSME-EIQGL-TDL-QLQEADE 942
ERA A DK+Q E +++ + +Q L++ + E +GL T+L +L+ E
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE 1538
Query: 943 EKERILAQLRELEK--KKKLEDAKSQEQVFGLD-KELKKLKKAVATSDKLATAELTIAKD 999
E L L+ K ++++ D Q + G +EL+K KKA+ A L A+
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598
Query: 1000 QLKSLHGTVMKINQERAEELQEAER-FSRKAAQAARDLTRAEAEIELLQNLL----RQKG 1054
L+ ++I E ++ E +R + K + A + +E LQ L R +
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658
Query: 1055 EQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLE 1114
E RL+ + G + LE++ + T RQ TE ++ + + G +
Sbjct: 1659 EALRLKKKMEG-----DLNDLELQLGHAT--RQATEAQAATRLMQAQLKEEQAGRDEEQR 1711
Query: 1115 EIAELRRE 1122
AEL +
Sbjct: 1712 LAAELHEQ 1719
Score = 95.1 bits (235), Expect = 7e-19
Identities = 157/709 (22%), Positives = 300/709 (42%), Gaps = 112/709 (15%)
Query: 517 LQMEKQKQEIAGKQKEIKDLQIAIDSLDSK----DPKHSHMKAQKSGKEQQLDIMNKQYQ 572
L+ + ++E+A + E++ L+ A+ + ++K + H + +K+ QL
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 573 QLESRLDEILSRIAKETEEIKDLEEQLT-EGQIAAN-EALKKDLEGVISGLQEYLGTIKG 630
E R ++ + ++K+L E+L E ++ A+ A ++ LE + L++ + +K
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 631 QATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690
+A+ E + E ++ LTE E+ A+D R L + + ALQE H
Sbjct: 1009 TLAKAEKE----KQATENKVKNLTE--------EMAALDESVAR--LTKEKKALQEAH-- 1052
Query: 691 NASLQQTQGDLSAYE----AELEARLNL-RDAEANQLKEELEKVTRL-TQLEQSALQAEL 744
QQ GDL A E A +A+L L + E + E EK R+ T+ + L+ +L
Sbjct: 1053 ----QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL 1108
Query: 745 EKERQALKNAL-GKAQFSEEKEQENSELHAKLKHLQDDNNL---LKQQLKDFQNHLNHVV 800
+ ++++ +A K Q E+ ++++SEL ++D+ L +++++K+ Q +
Sbjct: 1109 KLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168
Query: 801 DGLVRPEEVAARVDELRRKLKLGTGEMN--IHSPSDVLGKSLADLQKQFSEILARSKWER 858
+ L ARV++ R + E++ + +K+ +E L R + E
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAE-LGRLRREL 1227
Query: 859 DEAQVRE-------RKLQEEMALQQEKLATGQEEFRQACER-ALEARMNFDK-------- 902
+EA +R R+ Q E A + + + RQ E+ E RM D
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETL 1287
Query: 903 -----------RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEAD---EEKERIL 948
R +E ++ + + ++ LQ L +G + E EEKE ++
Sbjct: 1288 TRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLI 1347
Query: 949 AQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK------ 1002
+QL + K A+S E++ +E K K A+A + + + + ++Q +
Sbjct: 1348 SQL----SRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 1403
Query: 1003 -SLHGTVMKINQE--------------RAEELQEA-ERFSRKAAQAARDLTRAEAEIELL 1046
L + K N E R EEL+EA ++ + + +A + A A+ L
Sbjct: 1404 AELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSL 1463
Query: 1047 QNL---LRQKGEQFRLEMEK-TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTG 1102
+ L+ + E LE+E+ T + + +E+ E RQ E +Q L+
Sbjct: 1464 EKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE---MQRELEAAQ 1520
Query: 1103 SDNKG----------GFENVLEEIAELRREVSYQNDYISSMADPFKRRG 1141
+++G G E LE + L+RE + IS + D G
Sbjct: 1521 RESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSG 1569
Score = 94.7 bits (234), Expect = 9e-19
Identities = 148/748 (19%), Positives = 315/748 (42%), Gaps = 118/748 (15%)
Query: 271 EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNT 330
+VE L+R L + L+++ ++ ++ L L L QS EEL+ L
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 1370
Query: 331 KNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK 390
+++ K +A + +L +E + +A+ E AE+ + +
Sbjct: 1371 ESKA-KSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQ--------WR 1421
Query: 391 SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
S+Y+ + + ++ + + ++ E +E + + +L+ + + ++
Sbjct: 1422 SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481
Query: 451 TRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDL---LYKQLSGR---L 502
R + ++K ++ + RA EE ++ EE +Q L+ + L L++ G L
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
+ + L++E +L+ ++ +++ K I++L+ +L+ + S ++A E
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK---SEIQAALEEAEG 1598
Query: 563 QLDIMNKQYQQLESRLDEILS----RIAKETEE-----------IKDLEEQLTEGQIAAN 607
L++ + +++ L ++ + ++A++ EE ++ L+ L A N
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658
Query: 608 EAL--KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI 665
EAL KK +EG ++ L+ LG QAT+AQ R ++ + L E + RD+ +
Sbjct: 1659 EALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ-------LKEEQAGRDEEQR 1711
Query: 666 VAMDAENMRKELAELESALQ-EQHEVNASLQQTQGDLSAYEAEL---EARLNLRDAEANQ 721
+A + + L S L E E+ A+L+Q + E EL RLNL ++
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG 1771
Query: 722 LKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDD 781
L + +K+ + + + L E+E E QE E K K D
Sbjct: 1772 LLNQKKKL----EADLAQLSGEVE-----------------EAAQERREAEEKAKKAITD 1810
Query: 782 NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLA 841
++ ++LK + ++ +A ++ +++ L+ E+ A
Sbjct: 1811 AAMMAEELK--------------KEQDTSAHLERMKKTLEQTVRELQ------------A 1844
Query: 842 DLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFD 901
L++ L K + + + + R+L+ E+ +Q+K A AL+
Sbjct: 1845 RLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHA-----------EALKG----- 1888
Query: 902 KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLE 961
R+HE R++++ + +E+ K++ +Q L D +LQ + +R Q E E++
Sbjct: 1889 VRKHERRVKEL---AYQAEEDRKNLARMQDLVD-KLQSKVKSYKR---QFEEAEQQANTN 1941
Query: 962 DAKSQEQVFGLDKELKKLKKAVATSDKL 989
AK ++ LD ++ A ++KL
Sbjct: 1942 LAKYRKAQHELDDAEERADMAETQANKL 1969
Score = 84.3 bits (207), Expect = 1e-15
Identities = 127/549 (23%), Positives = 236/549 (42%), Gaps = 46/549 (8%)
Query: 270 EEVERLERDLEKKMIETEELKSK-------QTRFLEEIKNQDKLNKSLKEE----AMLQK 318
E L+R L K E + +SK +T LEE K + L EE A +
Sbjct: 1401 EAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKC 1460
Query: 319 QSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEI 378
S E+ K L T++E T+EL RA L+++ + A E E+
Sbjct: 1461 SSLEKAKLRLQTESE---DVTLELERATSAAAALDKKQRHLE-RALEERRRQEEEMQREL 1516
Query: 379 DKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQ 438
+ A ES +G ++ E+ + K ++ + D ++L G + + +
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELE 1576
Query: 439 LEDK--EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK 496
K E + S Q L E +E E + LR E Q++ + +K++E KD
Sbjct: 1577 KTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVD-RKLAE--KDEECA 1633
Query: 497 QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQK-EIKDLQI--------AIDSLDSKD 547
L Q + Q +LD E + + + K + ++ DL++ A ++ +
Sbjct: 1634 NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATR 1693
Query: 548 PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
+ +K +++G++++ + + ++Q ++ L+ S +A E EE++ EQ + A
Sbjct: 1694 LMQAQLKEEQAGRDEEQRLAAELHEQAQA-LERRASLLAAELEELRAALEQGERSRRLAE 1752
Query: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
+ L LE E L + Q T N+ +KL + L + E QER + E A
Sbjct: 1753 QEL---LEAT-----ERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA 1804
Query: 668 MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQL---KE 724
A +AE L+++ + +A L++ + L EL+ARL +AE L K+
Sbjct: 1805 KKAITDAAMMAE---ELKKEQDTSAHLERMKKTLEQTVRELQARLE--EAEQAALRGGKK 1859
Query: 725 ELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL 784
+++K+ + ++ L AE +K +ALK + +E + E L +QD +
Sbjct: 1860 QVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDK 1919
Query: 785 LKQQLKDFQ 793
L+ ++K ++
Sbjct: 1920 LQSKVKSYK 1928
Score = 80.5 bits (197), Expect = 2e-14
Identities = 111/503 (22%), Positives = 220/503 (43%), Gaps = 36/503 (7%)
Query: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL 1888
L + ++EL L + L ++A + + QE E S+ +E ++ L + +L
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 1889 HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM 1948
+ +L+ + +L+ + E + R ED ++ + + L++E E K + ++
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 1949 MFQRLQKERESEESK---LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005
+ +KE+++ E+K L L E +L KE + Q L + A E+RV
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068
Query: 2006 LQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
L + E+ E LE +L Q K+ + E+ + G+L Q+ AD + + Q
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESV----ADAAQDKQQ 1124
Query: 2062 FLTERKKAEKQVASLK---EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHER 2118
+ KK + +++ L E ++ +Q++K + E + +++E+ E A+ E+
Sbjct: 1125 LEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA-ERAARARVEK 1183
Query: 2119 AR-RLMKELNQMQYEYTELKKQMANQKD-LERRQMEISDAMRTLKSEVKDEIRTSLKNLN 2176
R +EL ++ E A Q++ +R+ E+ R L+ E ++ L
Sbjct: 1184 QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELE-EAALRHEATVAALR 1242
Query: 2177 QFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEA 2236
+ E A+L ++ + + +LE K L +++ ++ R +A
Sbjct: 1243 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD----------LAANVETLTRAKA 1292
Query: 2237 LREKL-RHREDRL---KAQLRHCMSKQAEVLI-KGKRQTE-GTLHSLRRQVDALGELVTS 2290
EKL R ED+L K ++ + A+ +G+ QTE G L L + + L ++
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 2291 TSADSASSPSLSQLESSLTEDSQ 2313
A +A SL +L L E+S+
Sbjct: 1353 GKALAAQ--SLEELRRQLEEESK 1373
Score = 73.9 bits (180), Expect = 2e-12
Identities = 108/515 (20%), Positives = 203/515 (39%), Gaps = 76/515 (14%)
Query: 1319 HNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE 1378
H E + LE + + K+ + E + S K ++EL L EK ++ +E
Sbjct: 1535 HGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALE 1594
Query: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREA 1438
E ++ + + I +E + E+++ L ++ EC RR+ R
Sbjct: 1595 EAEGALELEETKTLRI--QLELSQVKAEVDRKLAEKDE-----ECAN----LRRNHQRAV 1643
Query: 1439 DRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQL 1498
+ L A ++E E A R + E D +LE + +A
Sbjct: 1644 ESLQASLDAETRARNE-----------ALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692
Query: 1499 RSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE 1558
R +QA K+ + + +++ + E+++ Q L ++ L EL++L+ +E E
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHE-------QAQALERRASLLAAELEELRAALEQGE 1745
Query: 1559 RNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMV 1618
R+ + L E E+L +R L L SQ T + L+ L L G +
Sbjct: 1746 RS-----RRLAEQELLEATERLNL--LHSQNTGLLNQKKKLEADLAQ-------LSGEVE 1791
Query: 1619 QAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIE 1678
+A + +EA + +T+ E+K ++ + + + K L +E++
Sbjct: 1792 EAAQERREAEEKAKKAITDAAMMAEELK--------KEQDTSAHLERMKKTLEQTVRELQ 1843
Query: 1679 -KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK 1737
+ EE Q LR K +L + +V ELE A E+K
Sbjct: 1844 ARLEEAEQAALRGGKKQVQKL---------------------EAKVRELEAELDA--EQK 1880
Query: 1738 LELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD 1797
E L+ + + ++ E Q E D++ + RM LQS V+ ++ E+ +++ +
Sbjct: 1881 KHAEALKGVRKHERRVKELAYQ-AEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQAN 1939
Query: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
K + + L AEE + M ++ KL R
Sbjct: 1940 TNLAKYRKAQHELDDAEERADMAETQANKLRARTR 1974
Score = 52.4 bits (124), Expect = 5e-06
Identities = 81/380 (21%), Positives = 158/380 (41%), Gaps = 64/380 (16%)
Query: 243 HLRSLESLEGQ-PVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIK 301
H R++ESL+ T+ R EA RL++ +E + + E TR E +
Sbjct: 1639 HQRAVESLQASLDAETRARNEAL---------RLKKKMEGDLNDLELQLGHATRQATEAQ 1689
Query: 302 NQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKT------IELTRACQKQYELEQE 355
+L ++ +E + + L ++L+ + + L+++ +E RA +Q E +
Sbjct: 1690 AATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1749
Query: 356 LAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKK 415
LA ++ E LN S+ G K+ + A + + + ++
Sbjct: 1750 LAEQELLEATERLNLLHSQNT------------GLLNQKKKLEADLAQLSGEVEEAAQER 1797
Query: 416 MEPDEQLRNDHMN-------LRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
E +E+ + + L+ LE +K + + + EL +E+AEQ L
Sbjct: 1798 REAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTL---EQTVRELQARLEEAEQAAL 1854
Query: 469 RATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAG 528
R + KQ+++ + EA D K+ + L+ V K + +L Q E+ ++ +A
Sbjct: 1855 RGGK--KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLAR 1912
Query: 529 KQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
Q DL +D L SK +K+ K +Q+++ E + + L++ K
Sbjct: 1913 MQ----DL---VDKLQSK------VKSYK-----------RQFEEAEQQANTNLAKYRKA 1948
Query: 589 TEEIKDLEEQLTEGQIAANE 608
E+ D EE+ + AN+
Sbjct: 1949 QHELDDAEERADMAETQANK 1968
Score = 50.4 bits (119), Expect = 2e-05
Identities = 94/424 (22%), Positives = 186/424 (43%), Gaps = 55/424 (12%)
Query: 245 RSLESLEGQPVTTQDR-QEAFERFSLEEVERLERDLE---------KKMIETEE----LK 290
++ ++LEG+ Q +EA LEE + L LE +K+ E +E L+
Sbjct: 1577 KTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR 1636
Query: 291 SKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ-KQ 349
R +E ++ + EA+ K+ E +DL + ++ E A + Q
Sbjct: 1637 RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQ 1696
Query: 350 YELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409
+L++E A + + +E E +A + + + + A E Q
Sbjct: 1697 AQLKEEQAGRDEEQRLA------AELHEQAQALERRASLLAAELEELRAALE-------Q 1743
Query: 410 AVQIKKMEPDEQLR-NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
+ +++ E L + +NL H+ +T L +++KK+ A L++L E+E+A Q+
Sbjct: 1744 GERSRRLAEQELLEATERLNLL-HSQ-NTGLLNQKKKLEAD---LAQLSGEVEEAAQERR 1798
Query: 469 RATEEFKQ-LEEAIQLKKISEAGKDLLYKQLSGRLQLVNK-LRQEALDLELQMEKQKQE- 525
A E+ K+ + +A + + + +D S L+ + K L Q +L+ ++E+ +Q
Sbjct: 1799 EAEEKAKKAITDAAMMAEELKKEQDT-----SAHLERMKKTLEQTVRELQARLEEAEQAA 1853
Query: 526 IAGKQKEIKDLQIAIDSL----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESR--LD 579
+ G +K+++ L+ + L D++ KH+ +A K ++ + + YQ E R L
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHA--EALKGVRKHERRVKELAYQAEEDRKNLA 1911
Query: 580 EILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC 639
+ + K ++K + Q E + AN L K + Q L + +A A+ +
Sbjct: 1912 RMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKA-----QHELDDAEERADMAETQA 1966
Query: 640 RKLR 643
KLR
Sbjct: 1967 NKLR 1970
Score = 40.0 bits (92), Expect = 0.027
Identities = 35/167 (20%), Positives = 77/167 (46%), Gaps = 18/167 (10%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
+LE LE ++ L+++ E +A+ R +K++++L + +L E + + + E
Sbjct: 1827 HLERMKKTLEQTVRELQARLEEAE--QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884
Query: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
+ V+K +++ + E E K+L +D+VD+++ S+++
Sbjct: 1885 ALKGVRKHERRVKELAYQAE------EDRKNLARMQDLVDKLQ----------SKVKSYK 1928
Query: 1440 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
R EAE + + K + A + DA+ E+ A +L R ++
Sbjct: 1929 RQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 167 bits (424), Expect = 8e-41
Identities = 225/1054 (21%), Positives = 459/1054 (43%), Gaps = 105/1054 (9%)
Query: 1333 QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE-ELHRTVQKRQQQK 1391
+ + + K E + + +SE + +EL + LL+EK L+ +V+ E ++ +
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCE 909
Query: 1392 DFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR----EADRLLAEAES 1447
I ++ E+ + + E+I E+ ++ L SEL+ + + LA+ E
Sbjct: 910 QLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 969
Query: 1448 ELSCTKEKTKNAVE----------KFTDAKRSLLQTESDAEELERRAQETAVNLV----- 1492
E T+ K KN E K + K++L +T + + +A+E VN++
Sbjct: 970 EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLD-DLQAEEDKVNILTKAKT 1028
Query: 1493 KADQQLRSLQADAK-------DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTE 1545
K +QQ+ L+ + DLE+ K K E LK + ++D Q L +K EK
Sbjct: 1029 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEF 1088
Query: 1546 ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1605
E+ L IE + E + +KE + ++ E+E ++ +++ + L R+L
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 1606 KKEELHLLQGSMVQAKADLQ-------EALRLGETEVTEKCNHIREVKSLLEELSFQKGE 1658
E L G A+ +L + LR E T H V +L ++ + E
Sbjct: 1149 ISERLE-EAGGATSAQVELNKKREAEFQKLRRDLEEAT--LQHEAMVAALRKKHADSMAE 1205
Query: 1659 LNVQISER---KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
L QI K +L K E++ E ++L +SK K L+ + L+ + EL+
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK 1265
Query: 1716 KLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERM 1771
+ + + +++L + Q E +L+ + Q + Q +E K ++E
Sbjct: 1266 EEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 1772 TAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNV 1831
T AL ++ + + L+E+ + ++ A+ +R L+ A NS++ Q K E +
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA--NSEVAQWR-TKYETDA 1382
Query: 1832 RKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT 1891
+ +EL++ + ++ Q+ +E EAVN+ L + L +DL+
Sbjct: 1383 IQRTEELEEAKK-------KLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1435
Query: 1892 KHQD----VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
+ + L +Q K +SEW ++E+ Q E E Q++ + L E+ K+K V +E
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL--FKVKNVYEE 1493
Query: 1948 MMFQRLQKERESEESKLETSKVTLK-----EQQHQLEKELTDQKSKLDQVLSKVLAA-EE 2001
+ Q RE++ + E S +T + +Q H+LEK K +++Q ++ AA EE
Sbjct: 1494 SLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEK----IKKQVEQEKCEIQAALEE 1549
Query: 2002 RVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKE----ADSMRADFSL 2057
+L+ EE ++ L+Q K SE ++++ EK E+ L++ ++M++
Sbjct: 1550 AEASLEHEEGKILRIQLELNQVK---SEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606
Query: 2058 ---LRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELV--- 2111
RN L +KK E + ++ L ++L + +++ ++
Sbjct: 1607 EIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG 1666
Query: 2112 AQDNHERARRLMKELNQMQYEYTE----LKKQMANQKDLERRQMEISDAMRTLKSEVKDE 2167
+D E+ + + N +Q E E L++ ++K E+ ++ S+ ++ L ++
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 2168 IRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHI 2227
I T K L + +L +++E +++ + N E E K+ + +K + H+
Sbjct: 1727 INTK-KKLENDVSQLQSEVEEVIQESRNAE---EKAKKAITDAAMMAEELKKEQDTSAHL 1782
Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGEL 2287
E+++ ++ L+H + + ++ +KG ++ L + R+++ GE+
Sbjct: 1783 -----------ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE--GEV 1829
Query: 2288 VTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
++ + L + E + E + + KN
Sbjct: 1830 ENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1863
Score = 162 bits (410), Expect = 4e-39
Identities = 220/1032 (21%), Positives = 444/1032 (43%), Gaps = 133/1032 (12%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHN-IDDLLQEKKSLEC 1375
E H EN+V L + M L +E + SK + K ++E H +DDL E E
Sbjct: 970 EKHATENKVKNLTEEMAGL-----DETIAKLSKEK--KALQETHQQTLDDLQAE----ED 1018
Query: 1376 EVEELHRTVQKRQQQKDFIDGNVES-LMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
+V L + K +QQ D ++G++E +++E++ + E +++ +++ + ++
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG---DLKLAQESTMDMEND 1075
Query: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
++ D L + E E+S N + K D + +Q + +EL+ R +E +
Sbjct: 1076 KQQLDEKLEKKEFEIS-------NLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128
Query: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI 1554
+ DL + + EEI + + + A + + L+KK+E E QKL++D+
Sbjct: 1129 RASRAKAEKQRSDLSR---ELEEISERLEEAGGATSAQVE-LNKKREA---EFQKLRRDL 1181
Query: 1555 EMAERNEDHHLQVLKESEVLLQAKRAE----LEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
E A + + L++ A+ E L+++K ++ ++ E+ + L E +
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241
Query: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQL 1670
+AK +L++ R E +V+E E + L+ +L+ Q+ L + E QL
Sbjct: 1242 S-------KAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL 1294
Query: 1671 ----TLIKQEIEKEEENLQVV--LRQMSKHKTELKNIL-DMLQLENHELQGLKLQHD--- 1720
L+ Q ++ + Q + L+ + +T+ KN L LQ H+ L+ Q++
Sbjct: 1295 DEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ 1354
Query: 1721 ------QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE 1774
QR ++VA K E + +Q+ + ++ + + ++L E ++ +E + A+
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEH-VEAVNAK 1413
Query: 1775 SRALQSCVECLSKEKEDLQ---------------------EKCDIWEKKLAQTKRVLAAA 1813
+L+ + L E EDL + W++K +T+ L A+
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 1814 EENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSL---- 1869
++ S+ + L K++ + +L+ L R+ +L +IS + +Q+ E + ++ L
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533
Query: 1870 ---QEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQ 1926
++E +Q L A+ L H + +L Q L + SE + +K+EE Q
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEH---EEGKILRIQLELNQVKSEVDRKI--AEKDEEIDQ 1588
Query: 1927 QQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQK 1986
++ N ++V E M L E S L K ++E +L + +
Sbjct: 1589 ---------LKRNHTRVV--ETMQSTLDAEIRSRNDALRVKK--------KMEGDLNEME 1629
Query: 1987 SKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK 2046
+L+ + LAAE +R + + + + L R + ++QL LQ
Sbjct: 1630 IQLNH--ANRLAAES-LRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQA 1686
Query: 2047 EADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMA 2106
E + + A Q RK AE+++ E +++ +Q + +K+ + + + +
Sbjct: 1687 EIEELWATL----EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQS 1742
Query: 2107 TIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD 2166
+E V Q++ + K + ELKK+ LER + + ++ L+ + +
Sbjct: 1743 EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1802
Query: 2167 EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVH 2226
+ +LK + + +L A R LEGE+E+ ++ + +G + + ++
Sbjct: 1803 AEQLALKGGKKQIQKLEA-------RVRELEGEVENEQKRNAEAV-KGLRKHERRVKELT 1854
Query: 2227 IMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGE 2286
E R LR L+ D+L+A+++ +QAE + + Q+ L R+ L E
Sbjct: 1855 YQTEEDRKNVLR--LQDLVDKLQAKVK-SYKRQAE---EAEEQSNANLSKFRKLQHELEE 1908
Query: 2287 LVTSTSADSASS 2298
AD A S
Sbjct: 1909 --AEERADIAES 1918
Score = 154 bits (388), Expect = 1e-36
Identities = 208/1024 (20%), Positives = 442/1024 (43%), Gaps = 172/1024 (16%)
Query: 1443 AEAESELSCTKE---KTKNAVEKFTDAKRSLLQTE-----SDAEELERRAQETAVNLVKA 1494
AE E E++ KE KTK+ + K ++AKR L+ + + +L+ + Q A +L A
Sbjct: 846 AETEKEMATMKEEFQKTKDELAK-SEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI 1554
+++ + L ++KI+ E +KE+ + ++ L+ KK KL +E +L+KDI
Sbjct: 905 EER-------CEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957
Query: 1555 EMAE-----------------RNEDHHLQVLKESEVLLQAKRAELEKLKSQ----VTSQQ 1593
+ E +N + L E+ L ++ L++ Q + +++
Sbjct: 958 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017
Query: 1594 QEMAVLDRQLGHKKEELHLLQGSMVQ----------AKADLQEALRLGETEVTEKCNHIR 1643
++ +L + ++++ L+GS+ Q AK L+ L+L + + N +
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ 1077
Query: 1644 EVKSLLEELSFQ--------------KGELNVQISERKTQLTLIKQEIEKEEENLQVVLR 1689
++ LE+ F+ + +L +I E + ++ + +EIE E + +
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEK 1137
Query: 1690 QMSKHKTELKNILDML---------------------QLENHELQGLKLQHDQRVSELEK 1728
Q S EL+ I + L Q +L+ LQH+ V+ L K
Sbjct: 1138 QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRK 1197
Query: 1729 TQVAVLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
+ E E ++NLQ++ KQ LE++K E++ T + L S E +SK
Sbjct: 1198 KHADSMAELGEQIDNLQRV-----------KQKLEKEKSELKMETDD---LSSNAEAISK 1243
Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD-------Q 1840
K +L++ C E ++++ K + + +L+ + ++LD Q
Sbjct: 1244 AKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQ 1303
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
L+R K + I ++ QL+E+ +A N+L L + + +L ++ + + L
Sbjct: 1304 LSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1363
Query: 1901 QTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQR 1952
++ ++++W ++E Q+ EE ++ Q+LQ + +E K E QR
Sbjct: 1364 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQR 1423
Query: 1953 LQKERESEESKLETSK---VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL--- 2006
LQ E E +E S L ++Q +K L++ K K ++ +++ A+++ R+L
Sbjct: 1424 LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 2007 --------QEEERWCESLEKTLSQTKRQLSEREQQLVE---KSGELLALQKEADSMRADF 2055
+E E+L + ++++S+ +Q+ E + EL ++K+ + + +
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543
Query: 2056 SLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI------- 2108
+ + E ++ ++ L +S++++ + E+ +E +++ +
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST 1603
Query: 2109 ---ELVAQDNHERARRLMK-ELNQMQYEYT--------ELKKQMANQKDLERRQMEISDA 2156
E+ ++++ R ++ M+ +LN+M+ + L+ Q L+ Q+ + DA
Sbjct: 1604 LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663
Query: 2157 MRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NLPFT 2210
+R + ++K+++ + N E+ +L A LE+ E E EL E L T
Sbjct: 1664 LRG-QEDLKEQLAIVERRANLLQAEI-EELWATLEQTERSRKIAEQELLDASERVQLLHT 1721
Query: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAEV-- 2262
N K + E + ++ R+ E++ K A + + K+ +
Sbjct: 1722 QNTSLINTKKKLEN-DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA 1780
Query: 2263 -LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQEK 2320
L + K+ E T+ L+ ++D +L A + +LE+ + E + ++ Q++
Sbjct: 1781 HLERMKKNLEQTVKDLQHRLDEAEQL-----ALKGGKKQIQKLEARVRELEGEVENEQKR 1835
Query: 2321 NASA 2324
NA A
Sbjct: 1836 NAEA 1839
Score = 117 bits (292), Expect = 2e-25
Identities = 194/911 (21%), Positives = 366/911 (40%), Gaps = 147/911 (16%)
Query: 245 RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSK-------QTRFL 297
R+ LEG Q+ E + ++L+ LEKK E L SK + +
Sbjct: 1053 RAKRKLEGDLKLAQESTMDMEN----DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108
Query: 298 EEIKNQDKLNKSLKEEAMLQKQS---CEELKSDLNTKNELLKQKTIELTRACQKQYEL-- 352
++IK + L EE ++ S E+ +SDL+ + E + ++ E A Q EL
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168
Query: 353 EQELAFYKI--DAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQA 410
++E F K+ D + L + A K D +G+ ID+ Q
Sbjct: 1169 KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ-------------IDNLQR 1215
Query: 411 VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDK-EKKISAAQTRLSELHDEIEKAEQQILR 469
V+ K + +L+ + +L + ++ + EK + + ++SEL + E+ ++ I
Sbjct: 1216 VKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIND 1275
Query: 470 ATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK 529
T + +L+ +EAG+ +QL + LV++L + Q+E+ K ++ +
Sbjct: 1276 LTAQRARLQ--------TEAGE--YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 530 QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
K L A+ S D++ +QY++ + E+ ++K
Sbjct: 1326 TKAKNALAHALQS-----------------SRHDCDLLREQYEEEQEGKAELQRALSKAN 1368
Query: 590 EEIKDLEEQLTEGQIAANEAL---KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
E+ + I E L KK L + +E++ + + + ++L++E
Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEV 1428
Query: 647 ETLLQRLTEVEQERDQLEIVAMDAE--NMRKELAELESALQE-QHEVNASLQQTQG---- 699
E L+ ++ ER A+D + N K L+E + +E Q E+ AS ++++
Sbjct: 1429 EDLM-----LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 700 ---DLSAYEAELEARLNLRDAEANQLKE----------------ELEKVTRLTQLEQSAL 740
+ YE L+ LR N +E ELEK+ + + E+ +
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543
Query: 741 QAELEKERQALKNALGK-AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
QA LE+ +L++ GK + E Q SE+ K+ ++ + LK+ +
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST 1603
Query: 800 VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
+D +R A RV + + + L E+ ++ + + +SL + + IL ++ D
Sbjct: 1604 LDAEIRSRNDALRVKK-KMEGDLNEMEIQLNHANRLAAESLRN-YRNTQGILKETQLHLD 1661
Query: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
+A + L+E++A+ E R ++ EI L
Sbjct: 1662 DALRGQEDLKEQLAIV------------------------------ERRANLLQAEIEEL 1691
Query: 920 QENLKSMEEIQGLTDLQLQEADEEKERILAQLREL-EKKKKLEDAKSQ-----EQVFGLD 973
L+ E + + + +L +A E + + Q L KKKLE+ SQ E+V
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES 1751
Query: 974 KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERA-----EELQEAERFSRK 1028
+ ++ K T + EL K+Q S H MK N E+ L EAE+ + K
Sbjct: 1752 RNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1809
Query: 1029 AAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQR 1088
+ + + + EA + L+ GE + G +++L E R
Sbjct: 1810 GGK--KQIQKLEARVRELE------GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1861
Query: 1089 TEIARLQNVLD 1099
+ RLQ+++D
Sbjct: 1862 KNVLRLQDLVD 1872
Score = 115 bits (288), Expect = 5e-25
Identities = 210/1014 (20%), Positives = 404/1014 (39%), Gaps = 164/1014 (16%)
Query: 213 KLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLES----LEGQPVTTQDRQEAFERFS 268
K+KPL + E + T+ Q T L E+ LE + VT + +
Sbjct: 838 KIKPL---LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 269 LEEVERL---ERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELK 325
E + L E E+ + +L++K E + ++++N L + + C ELK
Sbjct: 895 QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK 954
Query: 326 SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDES 385
D++ +ELT A + E E+ K+ E E A +D+
Sbjct: 955 KDID---------DLELTLA---KVEKEKHATENKVKNLTE-------EMAGLDET---- 991
Query: 386 PYIGK-SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK 444
I K S+ K+ + T +D QA EDK
Sbjct: 992 --IAKLSKEKKALQETHQQTLDDLQAE----------------------------EDKVN 1021
Query: 445 KISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRL 502
++ A+T+L + D++E + +Q + + ++ + ++ LK E+ D+ + +
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM----ENDKQ 1077
Query: 503 QLVNKLRQEALDLELQMEKQKQEIAGK---QKEIKDLQIAIDSLDSKDPKHSHMKAQKSG 559
QL KL ++ ++ + K + E A + QK+IK+LQ I+ L + +A ++
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE---RASRAK 1134
Query: 560 KEQQLDIMNKQYQQLESRLDEILSRIAKETE-------EIKDLEEQLTEGQI---AANEA 609
E+Q ++++ +++ RL+E + + E E + L L E + A A
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194
Query: 610 LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMD 669
L+K ++ L E + ++ + + E +L+ E + L + + + LE +
Sbjct: 1195 LRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRS 1254
Query: 670 AENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV 729
E+ +++EL++ +EQ + L + L E +L+ +DA +QL +
Sbjct: 1255 LED---QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 730 TRLTQLEQSALQAELEKERQALKNALGKA-------------QFSEEKE----------Q 766
T+ Q+E+ L+ +LE+E +A KNAL A Q+ EE+E +
Sbjct: 1312 TQ--QIEE--LKHQLEEETKA-KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 767 ENSELH-----------AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDE 815
NSE+ + + L++ L Q+L++ + H+ V E+ R+
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 816 LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQ 875
L L S+ +L Q+ F ++L+ K + +E Q Q+E
Sbjct: 1427 EVEDLMLDV------ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL 1480
Query: 876 QEKLATGQEEFRQACERALEARMNFDKRQHE-----ARIQQMENEIHYLQENLKSMEEIQ 930
+L + + ++ ++ R Q E +I + +IH L++ K +E+ +
Sbjct: 1481 STELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540
Query: 931 GLTDLQLQEA----DEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATS 986
L+EA + E+ +IL EL + K D K E+ +D+ + + V T
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETM 1600
Query: 987 DKLATAELTIAKDQL---KSLHGTV--MKINQERAEE---------------LQEAERFS 1026
AE+ D L K + G + M+I A L+E +
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHL 1660
Query: 1027 RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETME 1085
A + DL A +E NLL+ + E+ +E+T A ++L+ + + +
Sbjct: 1661 DDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLH 1720
Query: 1086 RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKR 1139
Q T + + L+ S + E V++E + + MA+ K+
Sbjct: 1721 TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKK 1774
Score = 108 bits (269), Expect = 8e-23
Identities = 148/720 (20%), Positives = 317/720 (44%), Gaps = 107/720 (14%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
NLE LED + LK+K+ E++ + + ++ Q+E ++++E + L +
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306
Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVES------LMTE---------LEIEKSL-K 1412
K++ ++EEL +++ + K+ + ++S L+ E E++++L K
Sbjct: 1307 SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLA----EAE----------SELSCTKEKTKN 1458
+ ++ E ++R EL EA + LA EAE + L TK++ +N
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 1459 AVEKFT-DAKRSLLQT----------ESDAEELERRAQETAVNLVKADQQLRSLQAD--- 1504
VE D +RS + E +++ +ET L + ++ RSL +
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK 1486
Query: 1505 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
K++ + + Q E L+ NK + + SD + K EL+K++K +E E
Sbjct: 1487 VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ----EKCE 1542
Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
+Q L+E+E L+ + ++ +++ ++ + E+ DR++ K EE+ L+ + +
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHTRVVET 1599
Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
+Q L + E+ + + +R K + L E+ Q N +E + +++
Sbjct: 1600 MQSTL---DAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKET 1656
Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK 1737
+ +L LR K +L + ++LQ E EL L+ +R ++ + ++ E+
Sbjct: 1657 QLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWAT-LEQTERSRKIAEQELLDASER 1715
Query: 1738 LELENLQQISQ-QQKGEIEWQKQLLERDKREI--ERMTAESRALQSCVECLS-----KEK 1789
++L + Q S K ++E L+ + E+ E AE +A ++ + K++
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE 1775
Query: 1790 EDLQEKCDIWEKKLAQTKRVLA-----AAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
+D + +K L QT + L A + K + ++KLE VR+L+ E++
Sbjct: 1776 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN---- 1831
Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
+ + EAV L++ V++ ++D + + QD++ +L
Sbjct: 1832 -------------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLV----DKL 1874
Query: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
Q + + + E+ +++ + + LQ+E+EE + + E +L+ + +K+
Sbjct: 1875 QAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 105 bits (262), Expect = 5e-22
Identities = 122/625 (19%), Positives = 255/625 (40%), Gaps = 73/625 (11%)
Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
S + + E+ K+ ++ K E+ + A+ + L+ + L KEK DLQ
Sbjct: 845 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 1794 -EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
E+C+ K Q + + E ++ E+ +L RKL+ E +L +D L +
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 1853 SAMQQQLQEKREAVNSLQEELANVQDHL-NLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911
+ ++++ V +L EE+A + + + L+K+ HQ L D+
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL--------DDLQAE 1016
Query: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
++ K + +QQ+ L+ +E+ K + M +R +++ E + + S + +
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEK----KLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 1972 KEQQHQLEKELTDQKSKLDQVLSKV-------LAAEERVRTLQ----------EEERWCE 2014
+ + QL+++L ++ ++ ++SK+ + +++++ LQ E ER
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 2015 S-LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQV 2073
+ EK S R+L E ++L E G A + A+F LR + E V
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
A+L++ ++L + + ++ ++KE + +++ D A + K ++
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252
Query: 2134 TELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQ---FLPELPADLEAIL 2190
L+ Q++ K E Q + + + ++ ++ E + L++ + +L +A
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312
Query: 2191 ERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKA 2250
++ E L+ +LE E K + H + L + E KA
Sbjct: 1313 QQIEELKHQLEE--------------ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1358
Query: 2251 QLRHCMSK-QAEV----------LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSP 2299
+L+ +SK +EV I+ + E L +++ E V + +A AS
Sbjct: 1359 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLE 1418
Query: 2300 SLSQLESSLTEDSQLGQNQEKNASA 2324
Q + ED L + A A
Sbjct: 1419 KTKQRLQNEVEDLMLDVERSNAACA 1443
Score = 86.7 bits (213), Expect = 2e-16
Identities = 157/718 (21%), Positives = 319/718 (44%), Gaps = 107/718 (14%)
Query: 245 RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK-KMIETEELKSKQTRFLEEIKNQ 303
R + L Q Q + R L+E + L L + K T++++ + + EE K +
Sbjct: 1271 RLINDLTAQRARLQTEAGEYSR-QLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAK 1329
Query: 304 DKLNKSL----------KEEAMLQKQSCEELKSDLNTKN-ELLKQKTIELTRACQKQYEL 352
+ L +L +E+ +++ EL+ L+ N E+ + +T T A Q+ EL
Sbjct: 1330 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1389
Query: 353 EQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID-----S 407
E+ A K+ + + E+ E A S K R + + E ++D +
Sbjct: 1390 EE--AKKKLAQRLQEAE----EHVEAVNAKCASLEKTKQRLQNEV---EDLMLDVERSNA 1440
Query: 408 AQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI 467
A A KK +++ ++ T +LE +K+ + T L ++ + E++ Q+
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQKYEET--QAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 468 LRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQE 525
E K L++ I ++I+E GK Q+ ++ ++ QE +++ +E+ +
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGK-----QIHELEKIKKQVEQEKCEIQAALEEAEAS 1553
Query: 526 IAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY----QQLESRLD-E 580
+ ++ +I +Q+ ++ + S+ + + + K++++D + + + + ++S LD E
Sbjct: 1554 LEHEEGKILRIQLELNQVKSE------VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAE 1607
Query: 581 ILSR-----IAKETE-EIKDLEEQLTEGQIAANEALK--KDLEGVISGLQEYLG-TIKGQ 631
I SR + K+ E ++ ++E QL A E+L+ ++ +G++ Q +L ++GQ
Sbjct: 1608 IRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667
Query: 632 ATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVN 691
+ E + + + LLQ E+E+ LE + +EL + +Q H N
Sbjct: 1668 --EDLKEQLAIVERRANLLQ--AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 692 ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL 751
SL T+ L + + +QL+ E+E+V Q + AE EK ++A+
Sbjct: 1724 TSLINTKKKL--------------ENDVSQLQSEVEEVI------QESRNAE-EKAKKAI 1762
Query: 752 KNALGKAQFSEE--KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD-----GLV 804
+A A +EE KEQ+ S HL+ L+Q +KD Q+ L+ G
Sbjct: 1763 TDA---AMMAEELKKEQDTSA------HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1813
Query: 805 RPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
+ +++ ARV EL +++ N + K L +++ E+ ++ +E +
Sbjct: 1814 QIQKLEARVRELEGEVE------NEQKRNAEAVKGLRKHERRVKELT----YQTEEDRKN 1863
Query: 865 ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQEN 922
+LQ+ + Q K+ + + + +A E++ F K QHE + +I Q N
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVN 1921
Score = 76.3 bits (186), Expect = 3e-13
Identities = 98/490 (20%), Positives = 206/490 (42%), Gaps = 78/490 (15%)
Query: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
K A+T++ +A +E + + L K E ++L++++ L ++K ND+ QLQ
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEK----NDL-----QLQV 894
Query: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
+ EA + LA+ ++ + L+ + +L+ I E R E+ ++
Sbjct: 895 QSEA-----DSLADAEERC--------------EQLIKNKIQLEAKIKEVTERAEEEEEI 935
Query: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
+ + L++E E K + E+ +++KE+ + E+K+ K
Sbjct: 936 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---------------KN 980
Query: 1982 LTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGEL 2041
LT++ + LD+ ++K L +E++ +L++T QT L E ++ +
Sbjct: 981 LTEEMAGLDETIAK----------LSKEKK---ALQETHQQTLDDLQAEEDKVNILTKAK 1027
Query: 2042 LALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCI 2101
L+++ D + + + + K LK A Q S ++ +Q+ +
Sbjct: 1028 TKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---QESTMDMENDKQQLDEKLE 1084
Query: 2102 QKEMATIELVAQDNHERA--RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT 2159
+KE L+++ E+A +L K++ ++Q EL + ++E A R
Sbjct: 1085 KKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGE-----------EIEAERASRA 1133
Query: 2160 LKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNE-----G 2214
+ + ++ L+ +++ L E A +E N+ E E + L+ +L +
Sbjct: 1134 KAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
+K S + ++ + +++KL + LK + +S AE + K K E
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD-LSSNAEAISKAKGNLEKMC 1252
Query: 2275 HSLRRQVDAL 2284
SL QV L
Sbjct: 1253 RSLEDQVSEL 1262
Score = 60.8 bits (146), Expect = 1e-08
Identities = 76/333 (22%), Positives = 141/333 (42%), Gaps = 35/333 (10%)
Query: 1993 LSKVLAAEERVRTLQEE-ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
L K E+ + T++EE ++ + L K+ ++ K + L EK+ L +Q EADS+
Sbjct: 842 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 2052 RADF-----SLLRNQFLTERKKAE-----KQVASLKEALKIQRSQLEKNLLEQKQENSCI 2101
AD L++N+ E K E ++ + L ++ +LE E K++ +
Sbjct: 902 -ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL 960
Query: 2102 QKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLK 2161
+ +A +E + + L +E+ + +L K+ +K L+ + D ++ +
Sbjct: 961 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKE---KKALQETHQQTLDDLQAEE 1017
Query: 2162 SEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLN 2221
+V + K L + DLE LE+ + L +LE K L E L
Sbjct: 1018 DKVNILTKAKTK-----LEQQVDDLEGSLEQEKKLRMDLERAKRKL---------EGDLK 1063
Query: 2222 FSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQV 2281
+Q MD + L EKL +E + + +QA + Q + + L+ ++
Sbjct: 1064 LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEI-----QLQKKIKELQARI 1118
Query: 2282 DALGELVTSTSADSA-SSPSLSQLESSLTEDSQ 2313
+ LGE + + A A + S L L E S+
Sbjct: 1119 EELGEEIEAERASRAKAEKQRSDLSRELEEISE 1151
Score = 50.8 bits (120), Expect = 2e-05
Identities = 73/364 (20%), Positives = 161/364 (44%), Gaps = 50/364 (13%)
Query: 270 EEVERLERDLEKKMIET------EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323
EE+++L+R+ +++ET E++S+ + K + LN+ + + + E
Sbjct: 1584 EEIDQLKRN-HTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES 1642
Query: 324 LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD 383
L++ NT+ +LK+ + L A + Q +L+++LA + A N +E E+ +
Sbjct: 1643 LRNYRNTQG-ILKETQLHLDDALRGQEDLKEQLAIVERRA-----NLLQAEIEELWATLE 1696
Query: 384 ESPYIGKSRYKRNMFATESYIIDSAQAVQI------KKMEPDEQLRNDHMNLRGHTP-LD 436
++ +R+ E ++D+++ VQ+ + ++L ND L+ +
Sbjct: 1697 QT--------ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748
Query: 437 TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEA----- 489
+ + E+K A T + + +E++K + K LE+ ++ ++ EA
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1808
Query: 490 --GKDLLYK------QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQ 537
GK + K +L G ++ K EA+ + E++ +E+ + +K + LQ
Sbjct: 1809 KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQ 1868
Query: 538 IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE 597
+D L +K + K Q E+Q + ++++L+ L+E R ++ L
Sbjct: 1869 DLVDKLQAKVKSY---KRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRV 1925
Query: 598 QLTE 601
+ E
Sbjct: 1926 KSRE 1929
Score = 38.9 bits (89), Expect = 0.059
Identities = 49/239 (20%), Positives = 105/239 (43%), Gaps = 28/239 (11%)
Query: 2082 IQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMA 2141
++ ++ EK + K+E + E+A E ++ E+ L+KE N +Q +++ +
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQSEAD 899
Query: 2142 NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELE 2201
+ D E R ++ L++++K+ + + E+ A+L A + E+ EL+
Sbjct: 900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-----EEINAELTAKKRKLEDECSELK 954
Query: 2202 SLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAE 2261
++L T+ + E+ ++V + E G L E + +SK+ +
Sbjct: 955 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAK------------LSKEKK 1000
Query: 2262 VLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEK 2320
L + +QT L + +V+ L T A + + LE SL ++ +L + E+
Sbjct: 1001 ALQETHQQTLDDLQAEEDKVNIL------TKAKTKLEQQVDDLEGSLEQEKKLRMDLER 1053
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 164 bits (415), Expect = 9e-40
Identities = 229/1053 (21%), Positives = 462/1053 (43%), Gaps = 134/1053 (12%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + + ++ + A KR+ E E EL +IDDL +E E V+
Sbjct: 921 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
++ +D + L E +K+L+ H+ +D+++ E TL K + +L ++ D
Sbjct: 981 NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1037
Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
L E E ++ E+ K +E A+ S + E+D ++L+ + ++ + +
Sbjct: 1038 LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK 1097
Query: 1498 LRSLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
+ QA L Q KIK+ + ++E+ + + A+ + K++ L+ EL+++ + +E
Sbjct: 1098 IEDEQALGMQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQQ 1594
A +++ K+ E Q R +LE+ L Q+ + Q+
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216
Query: 1595 EMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
L+++ K E+ L +M +AK +L++ R E +++E E + L+ +
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 1652 LSFQK-------GELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
L+ Q+ GE + Q+ E+ T QL+ KQ ++ E L+ L + K K+ L +
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 1702 L-------DMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI 1754
L D+L+ + E Q K + QR ++VA K E + +Q+ + ++ +
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAEL-QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ---EKCDI------------- 1798
+ ++L + ++ +E + A+ +L+ + L E EDL E+ +
Sbjct: 1396 KLAQRLQDAEEH-VEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 1799 -----WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDIS 1853
W++K +T L A+++ S+ + L K++ + +L+ L R+ +L +IS
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 1854 AMQQQLQEKREAVNSLQ---EELANVQDHLNLAKQDLLHTTKHQD-VLLSEQTRLQKDIS 1909
+ +Q+ E + ++ L+ +++ + L A ++ + +H++ +L Q L + S
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 1910 EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV 1969
E + +K+EE Q ++ N +++V E M L E S + K
Sbjct: 1575 EVDRKI--AEKDEEIDQ---------MKRNHIRIV--ESMQSTLDAEIRSRNDAIRLKK- 1620
Query: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSE 2029
++E +L + + +L+ A E +R + + + + L R +
Sbjct: 1621 -------KMEGDLNEMEIQLNHANR---MAAEALRNYRNTQAILKDTQLHLDDALRSQED 1670
Query: 2030 REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKI---QRSQ 2086
++QL LQ E + +RA Q RK AE+++ E +++ Q +
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 2087 LEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL 2146
L + + + S IQ EM I A++ E+A++ + + M ELKK+ L
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMA---EELKKEQDTSAHL 1783
Query: 2147 ERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES-LKE 2205
ER + + ++ L+ + + + +LK + + +L A R LEGE+ES K
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEA-------RVRELEGEVESEQKR 1836
Query: 2206 NLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIK 2265
N+ E K+ ++ E R LR L+ D+L+A+++ +QAE +
Sbjct: 1837 NVEAVKGLRKHERKV--KELTYQTEEDRKNILR--LQDLVDKLQAKVK-SYKRQAE---E 1888
Query: 2266 GKRQTEGTLHSLRRQVDALGELVTSTSADSASS 2298
+ Q+ L RR L E AD A S
Sbjct: 1889 AEEQSNVNLSKFRRIQHELEE--AEERADIAES 1919
Score = 156 bits (395), Expect = 2e-37
Identities = 201/1050 (19%), Positives = 451/1050 (42%), Gaps = 133/1050 (12%)
Query: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS 1410
++EKEM + + +E E + +EL + Q+K+ + +L+++
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL---------QLQVQAE 898
Query: 1411 LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
D + + + KT ++ ++++E AE E E++ + T KR L
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTE-RAEDEEEINA----------ELTAKKRKL 947
Query: 1471 LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
E + EL++ + + L K +++ + + K+L + +E + ++ K A
Sbjct: 948 ---EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 1531 -------SDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELE 1583
D Q K LT+ KL++ ++ E + + ++ + E + +L+
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK 1064
Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG-ETEVTEKCNHI 1642
+ + + LD +L K+ E+ S +Q+K + ++AL + + ++ E I
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEM-----SGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 1643 REVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL 1702
E++ +E + + Q S+ +L I + +E+ + K + E + +
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM- 1178
Query: 1703 DMLQLENHELQGLKLQHDQRVSELEKTQV-AVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
+L+ LQH+ + L K +V E +++NLQ++ KQ L
Sbjct: 1179 ------RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV-----------KQKL 1221
Query: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
E++K E M E L S +E +SK K +L++ C E +L++ K +
Sbjct: 1222 EKEKSE---MKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278
Query: 1822 SNLEKLELNVRKLQQELD-------QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELA 1874
+ +L+ + ++LD QL+R K + I +++QL+E+ +A ++L L
Sbjct: 1279 AQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQ 1338
Query: 1875 NVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED--CQKEEETKQ------ 1926
+ + +L ++ + + L ++ ++++W ++E Q+ EE ++
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 1927 QQLQVLQNEIEENKLKLVQQEMMFQRLQKERES---EESKLETSKVTLKEQQHQLEKELT 1983
Q+LQ + +E K E QRLQ E E + + + L ++Q +K L
Sbjct: 1399 QRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILA 1458
Query: 1984 DQKSKLDQVLSKVLAAEERVRTL-----------QEEERWCESLEKTLSQTKRQLSEREQ 2032
+ K K ++ +++ A+++ R+L +E E+L++ ++++S+ +
Sbjct: 1459 EWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1518
Query: 2033 QLVE---KSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEK 2089
Q+ E + EL ++K+ + +++ + + E ++ ++ L +S++++
Sbjct: 1519 QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1578
Query: 2090 NLLEQKQENSCIQKEMATI----------ELVAQDNHERARRLMK-ELNQMQYEYTELKK 2138
+ E+ +E +++ I E+ ++++ R ++ M+ +LN+M+ + +
Sbjct: 1579 KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638
Query: 2139 QMA--------NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAIL 2190
A Q L+ Q+ + DA+R+ + ++K+++ + N E+ +L A L
Sbjct: 1639 MAAEALRNYRNTQAILKDTQLHLDDALRS-QEDLKEQLAMVERRANLLQAEI-EELRATL 1696
Query: 2191 ERNEN----LEGELESLKE--NLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHR 2244
E+ E E EL E L T N K + I E + ++ R+
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL-ETDISQIQGEMEDIIQEARNA 1755
Query: 2245 EDRLK------AQLRHCMSKQAEV---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADS 2295
E++ K A + + K+ + L + K+ E T+ L+ ++D +L A
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL-----ALK 1810
Query: 2296 ASSPSLSQLESSLTE-DSQLGQNQEKNASA 2324
+ +LE+ + E + ++ Q++N A
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESEQKRNVEA 1840
Score = 121 bits (304), Expect = 7e-27
Identities = 174/859 (20%), Positives = 366/859 (42%), Gaps = 144/859 (16%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRAS--KRQSE--KEMEELHHNIDDL-------LQE 1369
L+ ++ L+ ++ L+ + ER RA K++S+ +E+EE+ +++ ++
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167
Query: 1370 KKSLECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSL 1411
K E E +++ R +++ R++ D + N++ + +LE EKS
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1227
Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
E +D++ +T+ K + L + R L + SE+ +E+ + + T A+R+ L
Sbjct: 1228 MKME--IDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT-AQRARL 1284
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
QTES + ++T V+ Q R QA + +E+ K + EE +K + + A S
Sbjct: 1285 QTESGEYSRQLDEKDTLVS-----QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQS 1339
Query: 1532 ---DFQCLSKKKEKLTEELQKLQKDI-----EMAERNEDHHLQVLKESEVLLQAKRAELE 1583
D L ++ E+ E +LQ+ + E+A+ + ++ +E L +AK+
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK---- 1395
Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1643
KL ++ ++ + ++ + ++ LQ + D++ ++ N +
Sbjct: 1396 KLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDK 1455
Query: 1644 EVKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
+ ++ EL E + T+L IK E+ + L+ + R+ + E+ +
Sbjct: 1456 ILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1515
Query: 1701 ILDMLQLEN---HELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGE 1753
+ + + HEL+ +K Q +Q SEL E+ + ++ E+ ++ +Q Q K E
Sbjct: 1516 LTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1575
Query: 1754 IEWQKQLLERDKREIERMT---------------AESRALQSCVECLSKEKEDLQEKCDI 1798
++ +++ E+D+ EI++M AE R+ + K + DL E
Sbjct: 1576 VD--RKIAEKDE-EIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM--- 1629
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
E +L R+ A A N + Q+ L+ +L+ LD R + L ++ ++++
Sbjct: 1630 -EIQLNHANRMAAEALRNYRNTQAILKDTQLH-------LDDALRSQEDLKEQLAMVERR 1681
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEW 1911
+ + L+ L + +A+Q+LL ++ +L ++ T +L+ DIS+
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741
Query: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSK 1968
ED +Q +N E+ K + MM + L+KE+++ E + +
Sbjct: 1742 QGEMEDI----------IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 1969 VTLKEQQHQLEKE----LTDQKSKLDQVLSKVLAAE-----------ERVRTLQEEER-- 2011
T+K+ QH+L++ L K ++ ++ ++V E E V+ L++ ER
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKV 1851
Query: 2012 -------------------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMR 2052
+ L+ + KRQ E E+Q + +Q E +
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Query: 2053 ADFSLLRNQFLTERKKAEK 2071
+ +Q R K+ +
Sbjct: 1912 ERADIAESQVNKLRVKSRE 1930
Score = 117 bits (292), Expect = 2e-25
Identities = 181/906 (19%), Positives = 373/906 (41%), Gaps = 122/906 (13%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDK-LNKSLKEEAMLQK---QSCEELK 325
++++ LE L K E ++K EE+ D+ + K KE+ LQ+ Q+ ++L+
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 326 SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDES 385
++ + N L K K + + LEQE KI E
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK---KIRMDLE------------------- 1053
Query: 386 PYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKK 445
R KR + +S ++ K + DE+L+ + G L +++ED++
Sbjct: 1054 ------RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG---LQSKIEDEQAL 1104
Query: 446 ISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLV 505
Q ++ EL IE +LEE I+ ++ S A + LS L+ +
Sbjct: 1105 GMQLQKKIKELQARIE--------------ELEEEIEAERASRAKAEKQRSDLSRELEEI 1150
Query: 506 NKLRQEALD-LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL 564
++ +EA Q+E K+ A QK +DL+ + H + +++
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLE---------EATLQHEATAATLRKKHA 1201
Query: 565 DIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY 624
D + + +Q+++ L + ++ KE E+K + L ++A K +LE + L++
Sbjct: 1202 DSVAELGEQIDN-LQRVKQKLEKEKSEMKMEIDDLASNMETVSKA-KGNLEKMCRALEDQ 1259
Query: 625 LGTIKGQATQAQ-----------------NECRKLRDEKETLLQRLTEVEQE-RDQLEIV 666
L IK + + Q E + DEK+TL+ +L+ +Q Q+E +
Sbjct: 1260 LSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 667 AMDAENMRKELAELESALQ-EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE 725
E K + L ALQ +H+ + +Q YE E EA+ L+ A + K
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQ-------YEEEQEAKAELQRAMS---KAN 1369
Query: 726 LEKVTRLTQLEQSALQ--AELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNN 783
E T+ E A+Q ELE+ ++ L AQ ++ E+ ++AK L+
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKL------AQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 784 LLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
L+ +++D + ++ D++ + K E H+ + K L
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEE--THAELEASQKESRSL 1481
Query: 844 QKQFSEILARSKWERDEAQVRERK---LQEEMALQQEKLATGQEEFRQACERALEARMNF 900
+ +I + D+ + +R+ LQ+E++ E++A G + + ++ ++
Sbjct: 1482 STELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--EKIKKQVEQ 1539
Query: 901 DKRQHEARIQQMENEIHYLQENL----KSMEEIQGLTDLQLQEADEEKERILAQLRELEK 956
+K + +A +++ E + + + + + +++ D ++ E DEE +++ K
Sbjct: 1540 EKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQM--------K 1591
Query: 957 KKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA--TAELTIAKDQLKSLHGTVMKINQE 1014
+ + +S + LD E++ A+ K+ E+ I + + ++ +
Sbjct: 1592 RNHIRIVESMQST--LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1649
Query: 1015 RAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTG-ANSQ 1073
L++ + A ++ DL A +E NLL+ + E+ R +E+T A +
Sbjct: 1650 TQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1709
Query: 1074 VLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
+L+ + + + Q T + + L+ S +G E++++E + + M
Sbjct: 1710 LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMM 1769
Query: 1134 ADPFKR 1139
A+ K+
Sbjct: 1770 AEELKK 1775
Score = 110 bits (275), Expect = 2e-23
Identities = 145/709 (20%), Positives = 312/709 (44%), Gaps = 98/709 (13%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
NLE LED + +K+K+ E++ + + ++ Q+E ++++E + L +
Sbjct: 1248 NLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307
Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVES------LMTE---------LEIEKSL-K 1412
K++ ++EEL R +++ + K + ++S L+ E E+++++ K
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLAE----AE----------SELSCTKEKTKN 1458
+ ++ E ++R EL EA + LA+ AE + L TK++ +N
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 1459 AVEKF------TDAKRSLLQTESD-----AEELERRAQETAVNLVKADQQLRSLQADA-- 1505
VE T+A + L + E +++ +ET L + ++ RSL +
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 1506 -KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
K+ + + Q E LK NK + + SD + K EL+K++K +E E
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKSE 1543
Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
LQ L+E+E L+ + ++ +++ ++ + E+ DR++ K EE+ ++ + ++
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQMKRNHIRIVES 1600
Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
+Q L + E+ + + IR K + L E+ Q N +E + ++
Sbjct: 1601 MQSTL---DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657
Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGL--KLQHDQRVSELEKTQVAVLE 1735
+ +L LR K +L + ++LQ E EL+ + + ++++E E +
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1717
Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKE 1790
+ L +N I+ ++K E + + E + E AE +A ++ + K+++
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 1791 DLQEKCDIWEKKLAQTKRVLA-----AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
D + +K L QT + L A + K + ++KLE VR+L+ E++ +
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837
Query: 1846 LSL-------HNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
+ + + Q +E R+ + LQ+ + +Q + K+ + +V L
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897
Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
S+ R+Q ++ E+ ++ + + Q+ L+ + E K++ +E
Sbjct: 1898 SKFRRIQHEL-------EEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 108 bits (271), Expect = 5e-23
Identities = 226/1051 (21%), Positives = 425/1051 (40%), Gaps = 138/1051 (13%)
Query: 85 EALIKKLTKQDNLALIKS----LNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKI 140
E KK +D + +K L L+L+K +E + + +V NL+ + G
Sbjct: 939 ELTAKKRKLEDECSELKKDIDDLELTLAK--------VEKEKHATENKVKNLTEEMAGLD 990
Query: 141 EKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNL 200
E + KL K ++ ++ + + +LQ N + + L +++ L
Sbjct: 991 ETIAKLTKEKKALQEAHQ-------QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1043
Query: 201 KGNKISSLQDISKLKPLQDLI----SLILVENPVVTLPHYLQFTIFHLRSLES-LEGQPV 255
+ KI + +K K DL S + +EN L L+ F + L+S +E +
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQA 1103
Query: 256 TTQDRQEAFERFSLEEVERLERDLEKKMI---ETEELKSKQTRFLEEIKN---------- 302
Q+ + +E LE ++E + + E+ +S +R LEEI
Sbjct: 1104 LGMQLQKKIKELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 303 -QDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQK----TIELTRACQKQYELEQELA 357
Q ++NK + E ++ EE L++K EL ++Q+L
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222
Query: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKME 417
K + K E ++ S + KA K ++ A E Q +IK E
Sbjct: 1223 KEKSEMKME-IDDLASNMETVSKA--------KGNLEKMCRALED------QLSEIKTKE 1267
Query: 418 PDEQ-LRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFK- 475
++Q L ND R L T+ + +++ T +S+L + +Q + EE K
Sbjct: 1268 EEQQRLINDLTAQRAR--LQTESGEYSRQLDEKDTLVSQL----SRGKQAFTQQIEELKR 1321
Query: 476 QLEEAIQLKKI-------SEAGKDLLYKQLSGRLQLVNKLRQEA-LDLELQMEKQKQEIA 527
QLEE I+ K S DLL +Q QEA +L+ M K E+A
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEE--------QEAKAELQRAMSKANSEVA 1373
Query: 528 GKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAK 587
Q K AI + + + + E+ ++ +N + LE + R+
Sbjct: 1374 --QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE----KTKQRLQN 1427
Query: 588 ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKE 647
E E++ ++ + T AA + +++ + +++ ++ + +Q E R L E
Sbjct: 1428 EVEDLM-IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTE-- 1484
Query: 648 TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ----HE---VNASLQQTQGD 700
L + E+ DQLE + + +N+++E+++L + E HE + ++Q + +
Sbjct: 1485 -LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 701 LSAYEAELEARLNLRDA-------EANQLKEELEKVT---------------RLTQLEQS 738
L A E EA L + E NQ+K E+++ R+ + QS
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 739 ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQ--LKDFQNHL 796
L AE+ A++ L K + E E HA + N Q LKD Q HL
Sbjct: 1604 TLDAEIRSRNDAIR--LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL 1661
Query: 797 NHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK-QFSEILARSK 855
+ + +E A V+ L+ E+ + +A+ + SE +
Sbjct: 1662 DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1721
Query: 856 WERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ---- 911
+ ++KL+ +++ Q ++ +E R A E+A +A + E + +Q
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1781
Query: 912 -MENEIHYLQENLKSMEE-IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQV 969
+E L++ +K ++ + L L+ ++ +++ A++RELE + + E ++ E V
Sbjct: 1782 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAV 1841
Query: 970 FGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFS-RK 1028
GL K +K+K+ +++ L + +D + L V K + +AEE +E + K
Sbjct: 1842 KGLRKHERKVKELTYQTEEDRKNILRL-QDLVDKLQAKV-KSYKRQAEEAEEQSNVNLSK 1899
Query: 1029 AAQAARDLTRAEAEIELLQ---NLLRQKGEQ 1056
+ +L AE ++ + N LR K +
Sbjct: 1900 FRRIQHELEEAEERADIAESQVNKLRVKSRE 1930
Score = 103 bits (257), Expect = 2e-21
Identities = 130/624 (20%), Positives = 253/624 (40%), Gaps = 71/624 (11%)
Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
S + + E+ K+ E+ K E+ + A+ + L+ + L +EK DLQ
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 1794 -EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
E+CD K Q + + E ++ E+ +L RKL+ E +L +D L +
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 1853 SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWA 1912
+ ++++ V +L EE+A + + +AK TK + L + D+
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDE--TIAK-----LTKEKKALQEAHQQTLDDLQAEE 1018
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ---KERESEESKLETSKV 1969
++ K + +QQ+ L+ +E+ K + E ++L+ K + +E K
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQ 1078
Query: 1970 TLKEQQHQLEKELTDQKSKLD-------QVLSKVLAAEERVRTLQEE---ERWCES-LEK 2018
L E+ + E E++ +SK++ Q+ K+ + R+ L+EE ER + EK
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEK 1138
Query: 2019 TLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQF-----------LTERK 2067
S R+L E ++L E G A + A+F +R T RK
Sbjct: 1139 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 2068 KAEKQVASLKEAL-KIQR--SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMK 2124
K VA L E + +QR +LEK E K E + M T+ + + R L
Sbjct: 1199 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED 1258
Query: 2125 ELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKN----LNQFLP 2180
+L++++ + E ++++ N +R +++ + + + KD + + L Q +
Sbjct: 1259 QLSEIKTKEEE-QQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIE 1317
Query: 2181 ELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK 2240
EL LE ++ L L+S + + + +EE+ + + +
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ--YEEE---------------QEAKAE 1360
Query: 2241 LRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPS 2300
L+ + +++ +K I+ + E L +++ E V + +A AS
Sbjct: 1361 LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420
Query: 2301 LSQLESSLTEDSQLGQNQEKNASA 2324
Q + ED + + A A
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACA 1444
Score = 90.9 bits (224), Expect = 1e-17
Identities = 155/720 (21%), Positives = 313/720 (43%), Gaps = 121/720 (16%)
Query: 510 QEALDLELQMEKQKQEIA---GKQKEIKDLQIAIDSLDSKDPKHSHMKAQK---SGKEQQ 563
+E +++ + EK K+E+A K+KE+++ + + + K+ ++A+ + E++
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTL--MQEKNDLQLQVQAEADSLADAEER 908
Query: 564 LDIMNKQYQQLESRLDEILSRIAKETE---------------------EIKDLEEQL--T 600
D + K QLE+++ E+ R E E +I DLE L
Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 968
Query: 601 EGQIAANEALKKDLEGVISGLQEYLGTIKGQA-------TQAQNECRKLRDEKETLLQRL 653
E + A E K+L ++GL E + + + Q ++ + D+ TL +
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 654 TEVEQERDQLE-------IVAMDAENMRKEL-AELESALQEQHEVNASLQQTQGDLSAYE 705
++EQ+ D LE + MD E +++L +L+ A + ++ QQ L E
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE 1088
Query: 706 AE---LEARLNLRDAEANQLKEELEKV-TRLTQLEQS-----ALQAELEKERQALKNALG 756
E L++++ A QL+++++++ R+ +LE+ A +A+ EK+R L L
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL- 1147
Query: 757 KAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA----- 811
+ SE E+ A+++ + K++ +FQ + + ++ E AA
Sbjct: 1148 -EEISERLEEAGGATSAQIE-------MNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 812 ----------RVDELRR---KLKLGTGEM-----NIHSPSDVLGKSLADLQKQ---FSEI 850
++D L+R KL+ EM ++ S + + K+ +L+K +
Sbjct: 1200 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQ 1259
Query: 851 LARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF-RQACER-ALEARMNFDKRQHEAR 908
L+ K + +E Q +L ++ Q+ +L T E+ RQ E+ L ++++ K+ +
Sbjct: 1260 LSEIKTKEEEQQ----RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 909 IQ----QMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDA- 963
I+ Q+E EI +++ + DL L+E EE++ A+L+ K E A
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDL-LREQYEEEQEAKAELQRAMSKANSEVAQ 1374
Query: 964 ---KSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
K + +EL++ KK +A + A + + SL T ++ E + +
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434
Query: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL 1080
+ ER AA AA D + + + + +QK E+ E+E + + S E+ K+
Sbjct: 1435 DVER--TNAACAALD--KKQRNFDKILAEWKQKCEETHAELEAS--QKESRSLSTELFKI 1488
Query: 1081 NETMERQRTEIARL--------QNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISS 1132
E ++ L Q + DLT +GG + E+ +++++V + + +
Sbjct: 1489 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG--KRIHELEKIKKQVEQEKSELQA 1546
Score = 89.4 bits (220), Expect = 4e-17
Identities = 127/613 (20%), Positives = 258/613 (42%), Gaps = 87/613 (14%)
Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
C++ E + ++ E +Q SK E +W + + + EEL L Q
Sbjct: 1344 CDLLREQYEEEQEAKAE--LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
+ E VE ++ ++ K + VE LM ++E ++K ++ + I+ E
Sbjct: 1402 QDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWK 1461
Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
+E +K +EL + E+ +L K + KN ++ +D +
Sbjct: 1462 QKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1521
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAK-DLEQHKIKQ-----EEILKEINKI 1525
+ ELE+ ++ V K++ Q +A+A + E+ KI + ++ E+++
Sbjct: 1522 EGGKRIHELEKIKKQ--VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1579
Query: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV-----LKESEVLLQ-AKR 1579
+A KD + + + ++ E +Q D E+ RN+ L+ L E E+ L A R
Sbjct: 1580 IAEKDEEIDQMKRNHIRIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638
Query: 1580 AELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC 1639
E L++ +Q A+L K +LHL ++++ DL+E L + E
Sbjct: 1639 MAAEALRNYRNTQ----AIL------KDTQLHL--DDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
I E+++ LE+ +ER ++ +QE+ E +Q++ Q T L
Sbjct: 1687 AEIEELRATLEQ------------TERSRKIA--EQELLDASERVQLLHTQ----NTSLI 1728
Query: 1700 NILDMLQLENHELQGLK---LQHDQRVSELEK---TQVAVLEEKLELE------------ 1741
N L+ + ++QG +Q + E K T A++ E+L+ E
Sbjct: 1729 NTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 1742 NLQQISQQQKGEIEWQKQL-LERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
NL+Q + + ++ +QL L+ K++I+++ A R L+ VE K + + E
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE 1848
Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
+K+ + +N Q ++KL+ V+ +++ ++ + +Q +L+
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELE 1908
Query: 1861 EKREAVNSLQEEL 1873
E E + + ++
Sbjct: 1909 EAEERADIAESQV 1921
Score = 80.5 bits (197), Expect = 2e-14
Identities = 122/560 (21%), Positives = 240/560 (42%), Gaps = 75/560 (13%)
Query: 613 DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT----EVEQERDQLEIVAM 668
+ E ++ ++E K + + + + ++L ++ TL+Q +V+ E D L
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL-----EARLNLRDAEANQLK 723
+ + K +LE+ ++E E ++ +L+A + +L E + ++ D E K
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 724 EELE------KVTRLTQLEQSALQ---AELEKERQALKNALGKA--QFSEEKEQENSELH 772
E E KV LT+ E + L A+L KE++AL+ A + E+++ N+
Sbjct: 968 VEKEKHATENKVKNLTE-EMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1026
Query: 773 AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSP 832
AK+K L+QQ+ D + L +E R+D R K KL G++ +
Sbjct: 1027 AKIK--------LEQQVDDLEGSLE---------QEKKIRMDLERAKRKL-EGDLKLAQE 1068
Query: 833 SDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACER 892
S + + + ++Q E L + ++E Q K+++E AL + +E QA
Sbjct: 1069 STM---DIENDKQQLDEKLKKKEFEMSGLQ---SKIEDEQALGMQLQKKIKE--LQARIE 1120
Query: 893 ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLR 952
LE + ++ +Q + L+E + +EE G T Q++ + + R
Sbjct: 1121 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 953 ELEK------------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAK 998
+LE+ +KK D+ ++ EQ+ L + +KL+K + K+ +L
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEMKMEIDDLASNM 1239
Query: 999 DQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFR 1058
+ + G + K+ + ++L E + + + DLT A ++ + GE R
Sbjct: 1240 ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ------TESGEYSR 1293
Query: 1059 LEMEK----TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFEN 1111
EK + + G + +IE+L +E + + L + L + D + +E
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 1112 VLEEIAELRREVSYQNDYIS 1131
E AEL+R +S N ++
Sbjct: 1354 EQEAKAELQRAMSKANSEVA 1373
Score = 79.3 bits (194), Expect = 4e-14
Identities = 108/505 (21%), Positives = 224/505 (44%), Gaps = 61/505 (12%)
Query: 650 LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
L + E E+E ++ + E ++ELA+ E+ +E E +L Q + DL +L+
Sbjct: 843 LLKSAETEKEMANMK---EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL-----QLQ 894
Query: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENS 769
+ AEA+ L + E R QL ++ +Q E + +K +A E++E+ N+
Sbjct: 895 VQ-----AEADSLADAEE---RCDQLIKTKIQLEAK-----IKEVTERA---EDEEEINA 938
Query: 770 ELHAKLKHLQDDNNLLKQQLKDFQNHL------NHVVDGLVR--PEEVAARVDELRRKLK 821
EL AK + L+D+ + LK+ + D + L H + V+ EE+A + + + K
Sbjct: 939 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 998
Query: 822 LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMALQQEKLA 880
H ++L DLQ + ++ +K + + E QV + E +L+QEK
Sbjct: 999 EKKALQEAHQ------QTLDDLQAEEDKVNTLTKAKIKLEQQVDDL----EGSLEQEK-- 1046
Query: 881 TGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME-EIQGLTD----- 934
+ R ERA + ++ D + + +EN+ L E LK E E+ GL
Sbjct: 1047 ----KIRMDLERA-KRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101
Query: 935 ----LQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA 990
+QLQ+ +E + + +L E + ++ AK+++Q L +EL+++ + + +
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Query: 991 TAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLL 1050
+A++ + K + + + + A +K A + +L ++ ++ L
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1221
Query: 1051 RQKGEQFRLEMEKTGVGTGANSQVL-EIEKLNETMERQRTEIARLQNVLDLTGSDNKGGF 1109
++ + ++E++ S+ +EK+ +E Q +EI + +D
Sbjct: 1222 EKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQR 1281
Query: 1110 ENVLEEIAELRREVSYQNDYISSMA 1134
+ E E R++ ++ +S ++
Sbjct: 1282 ARLQTESGEYSRQLDEKDTLVSQLS 1306
Score = 77.0 bits (188), Expect = 2e-13
Identities = 105/538 (19%), Positives = 228/538 (42%), Gaps = 92/538 (17%)
Query: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
K A+T++ +A +E + + L K E ++L++++ L ++K ND+ QLQ
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEK----NDL-----QLQV 895
Query: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
+ EA + LA+ ++ D L+ + +L+ I E R ED ++
Sbjct: 896 QAEA-----DSLADAEERC--------------DQLIKTKIQLEAKIKEVTERAEDEEEI 936
Query: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
+ + L++E E K + E+ +++KE+ + E+K+ K
Sbjct: 937 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---------------KN 981
Query: 1982 LTDQKSKLDQVLSKVL----AAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
LT++ + LD+ ++K+ A +E + ++ + E TL++ K +L EQQ+ +
Sbjct: 982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKL---EQQVDDL 1038
Query: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097
G L ++ +R D + + + K A++ ++ + QL++ L +++ E
Sbjct: 1039 EGSL----EQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN----DKQQLDEKLKKKEFE 1090
Query: 2098 NSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAM 2157
S +Q ++ +D +L K++ ++Q EL++ ++E A
Sbjct: 1091 MSGLQSKI-------EDEQALGMQLQKKIKELQARIEELEE-----------EIEAERAS 1132
Query: 2158 RTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKEN-----LPFTMN 2212
R + + ++ L+ +++ L E A +E N+ E E + ++ + L
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 2213 EGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQL------RHCMSKQAEVLIKG 2266
+K S + ++ + +++KL + +K ++ +SK L K
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKM 1252
Query: 2267 KRQTEGTLHSLRRQVDALGELVTSTSADSA-----SSPSLSQLESSLTEDSQLGQNQE 2319
R E L ++ + + L+ +A A S QL+ T SQL + ++
Sbjct: 1253 CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Score = 42.7 bits (99), Expect = 0.004
Identities = 54/256 (21%), Positives = 117/256 (45%), Gaps = 28/256 (10%)
Query: 237 LQFTIFHLRS-LESLE-GQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETE--ELKSK 292
LQ I LR+ LE E + + Q+ +A ER L + KK +ET+ +++ +
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 293 QTRFLEEIKN-QDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL--LKQKTIELTRACQKQ 349
++E +N ++K K++ + AM+ EELK + +T L +K+ + + Q +
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMM----AEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800
Query: 350 YELEQELAFYKIDAKFEPLNYYPSEY---AEIDKAPDESPYIGKSRYKRNM----FATES 402
+ ++LA + + L E E ++ + G +++R + + TE
Sbjct: 1801 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEE 1860
Query: 403 Y---------IIDSAQA-VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTR 452
++D QA V+ K + +E ++NL + +LE+ E++ A+++
Sbjct: 1861 DRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920
Query: 453 LSELHDEIEKAEQQIL 468
+++L + + +I+
Sbjct: 1921 VNKLRVKSREVHTKII 1936
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 164 bits (414), Expect = 1e-39
Identities = 232/1062 (21%), Positives = 467/1062 (43%), Gaps = 131/1062 (12%)
Query: 1321 LENEVSRLEDIMQHLK-------SKKREERWMRASKRQSEKEMEELHHNIDDLLQ-EKKS 1372
LE+EVSR ++ + ++ K + + + +K E ++E D L + EK++
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMT-ELEIEKSLKHHEDIVDEIECIEKTLLKR 1431
L+ + + LH +R + I+ +E MT E+ ++S+ + E+E I +T
Sbjct: 385 LQLKAK-LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT---- 439
Query: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
SEL EA + E E T + + K +SL +T + + A +
Sbjct: 440 -SELSEAPQKSLGHE-----VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
Query: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
+K +++ + L K+ EIL+ N+IV K S C + K+ + E+ Q L+
Sbjct: 494 LKMEKENQRLS-----------KKVEILE--NEIVQEKQSLQNCQNLSKDLMKEKAQ-LE 539
Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ------QQEMAVLDRQLGH 1605
K IE N + +++L++ L + L + +SQ++++ ++E +L +
Sbjct: 540 KTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAEARVKDIEKENKILHESIKE 598
Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGET--EVTEKCNHIREVKSLLEELSFQKGELNVQI 1663
+L ++ Q K +L+ GE E+ + +H+ + LL QK N++I
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL-----QKKITNLKI 653
Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHD 1720
+ K + +E+E L+ R++ K KN+ L+ L+ EN +L L+
Sbjct: 654 TCEKIEA------LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
+ V L+ + + + +LE + L+ +Q K +E K ++ +R L+
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER-----------LEV 756
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK------- 1833
+ L E + LQ+ + KK+ Q + L E ++ Q NLE+L+++ ++
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 1834 ---LQQELDQLNRDKLSLHNDISAMQQQ-------LQEKREAVNSLQEELANVQDHLNLA 1883
L+QE QL +DK L + ++QQ L+E + +L++E + + +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQ---QLQVLQNEIEE-- 1938
K+ + + + R DI ED E+ QQ L+ L +E+E+
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 1939 -NKLKLVQQEMMFQRLQKERESE-ESKLETSKVTLKEQQHQLE---KELTDQKSKLDQVL 1993
NK +L+ E K ES+ ES L+ S +E+ LE +E T+ +L Q L
Sbjct: 937 LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
Query: 1994 SKVLAAEERVRTLQEEERWCES---LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADS 2050
V E ++ Q+EER +S + ++ +R+ E ++L++ L+ +++ +
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 2051 MRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIEL 2110
++A+ L+ Q KQ+ + L+ Q L++ + +++N+ +Q + A +++
Sbjct: 1057 LQAEKQALKTQL--------KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 2111 VAQDNHERARRLMKELNQMQYEYTELKKQ----MANQKDL---------ERRQMEISDAM 2157
+ ++ LM + Q+ + + L+ + + ++DL + ++E+
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168
Query: 2158 RTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFE 2217
+ + E +LK+ ++ L DLE + +G+LE L++ L + E
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228
Query: 2218 EKLNFSQVHIMDEHWRGEALREKLRHREDRL--KAQLRHCMSKQAEVLIKGKR----QTE 2271
K N V + GE ++L H +L + ++ K + L+ + + E
Sbjct: 1229 NK-NHETVAAEYKKLCGE--NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 2272 GTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQ 2313
L+ Q L +TST ++ LSQL+ +L E+++
Sbjct: 1286 AEFSKLKEQYQQLD--ITSTKLNN-QCELLSQLKGNLEEENR 1324
Score = 147 bits (372), Expect = 9e-35
Identities = 198/941 (21%), Positives = 419/941 (44%), Gaps = 108/941 (11%)
Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
+KR + LA+A++++ +++ + E+ D K+ L Q E + +R Q+
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL----KRLQQEN 295
Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
+NL+ + R + + L + ++ +++ E+++ + D + + E+L E+ Q
Sbjct: 296 MNLLSDARSARMYRDELDALREKAVRVDKLESEVSR-YKERLHDIEFYKARVEELKEDNQ 354
Query: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
L + M E E K ELEK Q+ ++ +M ++R + KK
Sbjct: 355 VLLETKTMLEDQ--------LEGTRARSDKLHELEKENLQLKAKLHDME-MERDMDRKKI 405
Query: 1609 ELHLLQGSM---VQAKADLQEALRLG-ETEVTEKCNHIREVKSLLEELSFQKGELNVQIS 1664
E L++ +M + K + E+L LG E E + + + E + L + EL
Sbjct: 406 E-ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ--KSLGHEVNEL----- 457
Query: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
T L+K E+E + ++K EL+ +D ++ ++ ++ ++ +
Sbjct: 458 ---TSSRLLKLEMENQ---------SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505
Query: 1725 ELEKTQVAVLEEKLELENLQQISQ---QQKGEIEWQ-KQLLERDKREIERMTAESRALQS 1780
++E + +++EK L+N Q +S+ ++K ++E + L E +R+I+ + E+ L
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
V L ++ Q + K + + ++L E+ K S L K+E R++++EL+
Sbjct: 566 TVSSL---RQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEH 619
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
++K ++ L+++ E LQ+++ N L + + + + L E
Sbjct: 620 Y-KEKGERAEELENELHHLEKENEL---LQKKITN----LKITCEKIEALEQENSELERE 671
Query: 1901 QTRLQKDISEWAN---RFEDCQKEEETKQQQLQVLQNEIEENK---LKLVQQEMMFQRLQ 1954
+L+K + + N + E +KE ++ L+ +E K +K+ Q ++ + L+
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 1955 KERESEESKLETSKVTLKE-------------QQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
E+E + LE K + K+ + +L+K L + K+ Q+ S++ E
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 2002 RVRTLQE-------EERWCESLE---KTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
+TLQ+ + E LE K+L Q QL + ++QL +++ L + D+
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 2052 RADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELV 2111
+ ++ E K K++ KE+ ++ +LEK E + + K + T+
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESC-VRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 2112 AQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTS 2171
+ +++ +L ++ + EL+K N++ L + D + L+S+++ ++ S
Sbjct: 911 LVSEKLKTQQMNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 2172 LKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM--D 2229
L+ + + L A LE N+ L EL+++K+N + + EE++ S I D
Sbjct: 968 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGED 1026
Query: 2230 EHWRGEA---LREKLRHRE-----DRLKAQL---RHCMSKQAEVLIKGKRQTEGTLHSLR 2278
W E+ RE L+ ++ +R A L + + Q + L + + +L+
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
Query: 2279 RQVDALGELVTSTSADSA-----SSPSLSQLESSLTEDSQL 2314
RQ +L E T+ +A +S SQ S + +++QL
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Score = 123 bits (309), Expect = 2e-27
Identities = 186/873 (21%), Positives = 379/873 (43%), Gaps = 101/873 (11%)
Query: 1318 HHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
H +++ S+L I + K+E + K + E+ EEL + + L +E + L+ ++
Sbjct: 593 HESIKETSSKLSKIEFEKRQIKKE---LEHYKEKGERA-EELENELHHLEKENELLQKKI 648
Query: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELRE 1437
L T +K + + N E +++K+L +++ ++E +E K S+L E
Sbjct: 649 TNLKITCEKIEALE---QENSELERENRKLKKTLDSFKNLTFQLESLE----KENSQLDE 701
Query: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD-Q 1496
+ L L C K + LQ E+ E E+ + + L+KA +
Sbjct: 702 ENLELRRNVESLKC------------ASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
+ L+ + L+ + ++ L+ NK + +S+ Q L + + L + L++L
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL------ 803
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
+ L+ L++ L+ + ++LEK K Q+ + + + EE ++ G+
Sbjct: 804 --KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
+ + L + + + E C ++E++ +EL ++ +++ KT +TL +++
Sbjct: 862 LEKENKTLSKEIGI----YKESCVRLKELEKENKEL-VKRATIDI-----KTLVTL-RED 910
Query: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736
+ E+ Q QM+ +L + L+ + L L + D R LE + L++
Sbjct: 911 LVSEKLKTQ----QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK 966
Query: 1737 KLEL--ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794
LE+ E + + + + + +QL R + + + E+ + E + + +
Sbjct: 967 SLEIKEEKIAALEARLEESTNYNQQL--RQELKTVKKNYEALKQRQDEERMVQSSPPISG 1024
Query: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISA 1854
+ + WE++ +T R L ++ + N L+ + L+ +L QL +L I A
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 1855 MQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
+Q+Q +E +LQ + A +Q + LL +Q+ L+ N
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE-------NE 1137
Query: 1915 FEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 1974
E KE E L+ L + + ++ KL E++ +R E ES SK TLK
Sbjct: 1138 NESVIKERE----DLKSLYDSLIKDHEKL---ELLHERQASEYESLISK----HGTLKSA 1186
Query: 1975 QHQLEKELTDQKSKLDQVLSKVLAAE--ERVRTLQEEERWCESL-EKTLSQTKRQLSERE 2031
LE E D + + +Q+L + E E++ +++E+ E+ +T++ ++L
Sbjct: 1187 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246
Query: 2032 QQLVEKSGELLALQKEADSMRADF----SLLRNQFLTERKKAEKQVASLKEALKIQRSQL 2087
+L +LL KE + ++ D SLL N L E+ + E + + LKE Q QL
Sbjct: 1247 DRLNHTYSQLL---KETEVLQTDHKNLKSLLNNSKL-EQTRLEAEFSKLKE----QYQQL 1298
Query: 2088 EKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQMQYEYTELKKQMANQK 2144
+ + K N C EL++Q + E R L+ ++ + + L +Q K
Sbjct: 1299 D--ITSTKLNNQC--------ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 2145 DL----ERRQMEISDAMRTLKSEVKDEIRTSLK 2173
DL +R+ ++ + +R K +++++I K
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
Score = 115 bits (288), Expect = 5e-25
Identities = 182/897 (20%), Positives = 369/897 (41%), Gaps = 150/897 (16%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
E H+LE E L+ + +LK + + + E+E +L +D K+L +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF----KNLTFQ 688
Query: 1377 VEELHRTVQKRQQQKDFIDGNVESL------MTELEIEKSLKHHEDIVDEIECIEKTLLK 1430
+E L + + ++ + NVESL M +L++E ++++ E E ++K L
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE-----NKELESEKEQLKKGLEL 743
Query: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490
++ ++ +RL + L ++ + +E ++ + + Q ES+ ++LE Q N
Sbjct: 744 LKASFKKTERLEVSYQG-LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKN 799
Query: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
L L+ +K LEQ L K+ + L +E +L
Sbjct: 800 -------LEELKISSKRLEQ-------------------------LEKENKSLEQETSQL 827
Query: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
+KD + E+ Q + + L+ ++ L+ + + +E+ + KE
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKC------NHIREVKSLLEELSFQKGEL----- 1659
+ + +A D++ + L E V+EK N + ++ LE++ K L
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 1660 ----NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
++ E K + TL K+ +E +EE + + ++ + + + L+ + L
Sbjct: 948 STDDRYKLLESKLESTL-KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006
Query: 1716 KLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAES 1775
K + D+ ++ + K E E SQ+ E+ K L +R + AE
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERE-----SQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQ 1835
+AL++ ++ L + +LQ + LA ++ ++ E+N+ ++ N KLQ
Sbjct: 1062 QALKTQLKQLETQNNNLQAQI------LALQRQTVSLQEQNTTLQTQN--------AKLQ 1107
Query: 1836 QELDQLNRDKLSLHN---DISAMQQQLQEKREAVNSLQEELANVQDHL--NLAKQDLLH- 1889
E LN SL N + Q L+ + E+V +E+L ++ D L + K +LLH
Sbjct: 1108 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHE 1167
Query: 1890 -TTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM 1948
+ L+S+ L ++ + L+V ++E+ +L++Q+
Sbjct: 1168 RQASEYESLISKHGTL------------------KSAHKNLEVEHRDLEDRYNQLLKQKG 1209
Query: 1949 MFQRLQKERESEESKLETSKVTLKEQQHQL----EKELTDQKSKLDQVLSKVLAAEERVR 2004
+ L+K K+E K+ L+ + H+ K+L + +L+ S++L E
Sbjct: 1210 QLEDLEK-----MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--- 1261
Query: 2005 TLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLT 2064
LQ + + +SL + +L +L E+ +L + ++ S L+
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321
Query: 2065 ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMK 2124
E + Q+ + L +Q + LLEQ E+ + H R+ +
Sbjct: 1322 ENRHLLDQI----QTLMLQ----NRTLLEQNMESKDL-------------FHVEQRQYID 1360
Query: 2125 ELNQMQYEYTELKKQMANQKDL------ERRQMEISDAMRTLKSEVKDEIRTSLKNL 2175
+LN+++ + +L++++ +Q RR I+ MR L KD R K+L
Sbjct: 1361 KLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL 1417
Score = 107 bits (266), Expect = 2e-22
Identities = 143/684 (20%), Positives = 302/684 (44%), Gaps = 104/684 (15%)
Query: 445 KISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL-- 502
+++ A+ ++ L E+E+ +Q+L +E +Q+E I+LK++ + +LL S R+
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQME--IELKRLQQENMNLLSDARSARMYR 309
Query: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
++ LR++A ++++K + E++ ++ + D++ ++ + + K+ E
Sbjct: 310 DELDALREKA----VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 563 QLD----------IMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK 612
QL+ + K+ QL+++L ++ + ++I++L E+ ++A +++ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 613 DL------------EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
L + Q+ LG + T ++ KL E ++L + + E+
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR--LLKLEMENQSLTKTVEELRTTV 483
Query: 661 DQLE-----IVAMDAENMR--KELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLN 713
D +E I+ M+ EN R K++ LE+ + ++ + + Q DL +A+LE +
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI- 542
Query: 714 LRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHA 773
L+E E+ ++ + E L + RQ ++ + ++ E+EN LH
Sbjct: 543 ------ETLRENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHE 594
Query: 774 KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPS 833
+K + ++ + + + L H +E R +EL +L ++ +
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHY-------KEKGERAEELENELH------HLEKEN 641
Query: 834 DVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQ------EEMALQQEKLATGQEEFR 887
++L K + +L+ +I A + E E + RKL+ + + Q E L ++E
Sbjct: 642 ELLQKKITNLKITCEKIEALEQ-ENSELERENRKLKKTLDSFKNLTFQLESL---EKENS 697
Query: 888 QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
Q E LE R N E+LK L+ +E + EKE++
Sbjct: 698 QLDEENLELRRNV--------------------ESLKCASMKMAQLQLENKELESEKEQL 737
Query: 948 LAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
L L+ KK E + Q GLD E ++L+K + S+K +L L+ +
Sbjct: 738 KKGLELLKASFKKTERLEVSYQ--GLDIENQRLQKTLENSNK-KIQQLESELQDLEMENQ 794
Query: 1007 TVMKINQE---RAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK 1063
T+ K +E ++ L++ E+ ++ Q L + + ++E LRQ+ E +E+
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Query: 1064 TGVGTGANSQVLEIEKLNETMERQ 1087
V G +EK N+T+ ++
Sbjct: 855 NNVKIG------NLEKENKTLSKE 872
Score = 105 bits (263), Expect = 4e-22
Identities = 206/965 (21%), Positives = 409/965 (42%), Gaps = 161/965 (16%)
Query: 260 RQEAFERFSLE------EVERLERDLEKKM--------------IETEELKSKQTRFLEE 299
R E+ + S+E ++ RL ++LE+K IE + L+ + L +
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 300 IKN----QDKLNKSLKEEAM--------------------LQKQSCEELKSD----LNTK 331
++ +D+L+ +L+E+A+ K EELK D L TK
Sbjct: 302 ARSARMYRDELD-ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 332 NELLKQKTIELTRA-CQKQYELEQELAFYKI---------DAKFEPLNYYPSEYAEIDKA 381
L Q +E TRA K +ELE+E K D + + E ++ A
Sbjct: 361 TMLEDQ--LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 382 P----DESPYIG--KSRYKRNMFATES------YIIDSAQAVQIKKMEPD--------EQ 421
DES ++G + R +E+ + ++ + ++ K+E + E+
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 422 LRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL-EEA 480
LR ++ G+ ++E + +++S ++ L +EI + +Q + K L +E
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLS---KKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 481 IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ--- 537
QL+K E ++ +Q+ + + E L+ + +Q+ +I+ + + +KD++
Sbjct: 536 AQLEKTIETLRENSERQIK-----ILEQENEHLNQTVSSLRQRSQISAEAR-VKDIEKEN 589
Query: 538 -IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE--EIKD 594
I +S+ K S ++ +K +++L+ ++ ++ E L+ L + KE E + K
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKI 648
Query: 595 LEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT 654
++T +I A E +LE L++ L + K Q ++ L E L +
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENL 704
Query: 655 EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNL 714
E+ + + L+ +M ++ E ELES E+ ++ L+ + E LE
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELES---EKEQLKKGLELLKASFKKTE-RLEVSYQG 760
Query: 715 RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK---------- 764
D E +L++ LE + Q +S LQ +LE E Q L+ L + + S ++
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQ-DLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 765 -EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLG 823
EQE S+L K L+ +N L+QQ + L EE ++ L ++ K
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL----------EENNVKIGNLEKENKTL 869
Query: 824 TGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMALQQ-----E 877
+ E+ I+ S V L +L+K+ E++ R+ + + +RE + E++ QQ E
Sbjct: 870 SKEIGIYKESCV---RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
Query: 878 KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIH-YLQENLKSMEEIQGLTDLQ 936
KL E+ ER L D++ + R + +E+++ L+++L+ EE + +
Sbjct: 927 KLTHELEKIGLNKERLLH-----DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEAR 981
Query: 937 LQEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELT 995
L+E+ +++ +L+ ++K + L+ + +E++ + + T EL
Sbjct: 982 LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
Query: 996 IAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGE 1055
KD+L +++ + A E + + Q +A+I LQ E
Sbjct: 1042 KVKDRL-------IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1094
Query: 1056 QFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEE 1115
Q T +Q +++ N T+ Q T + L + S + E+V++E
Sbjct: 1095 Q----------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 1116 IAELR 1120
+L+
Sbjct: 1145 REDLK 1149
Score = 103 bits (256), Expect = 3e-21
Identities = 189/832 (22%), Positives = 349/832 (41%), Gaps = 122/832 (14%)
Query: 265 ERFSLEEVERLERDLEK------KMIET-EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
E+ SL+ + L +DL K K IET E +Q + LE+ + LN+++
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ--ENEHLNQTVSSLRQRS 574
Query: 318 KQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE 377
+ S E D+ +N++L + E + K + F K K E L +Y +
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSK-------IEFEKRQIKKE-LEHYKEKGER 626
Query: 378 IDKAPDESPYIGKSRYKRNMFATESYII-DSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
++ +E ++ K T I + +A++ + E + + R L L
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
Query: 437 TQLEDKEKKISAAQTRLSELHDEIEK---AEQQILRATEEFKQLE-EAIQLKK------- 485
QLE EK+ S EL +E A ++ + E K+LE E QLKK
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 486 ---------ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL 536
+S G D+ ++L L+ NK Q+ LE +++ + E QK +++L
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ---LESELQDLEMENQTLQKNLEEL 803
Query: 537 QIAIDSLDSKDPKHSHMKAQKSGKEQ---QLDIMNKQYQQ----LESRLDEILSRIAKET 589
+I+ L+ + ++ ++ + S E+ QL+ NK+ +Q ++ L+E +I
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 590 EEIKDLEEQL---TEGQIAANEALKKDLEGV---------ISGLQEYLGTIKGQATQAQN 637
+E K L +++ E + E K++ E V + L+E L + K + Q N
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 638 ECRKLRDEKETL---LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
+ KL E E + +RL EQ D + + ++LES L++ SL
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTD---------DRYKLLESKLESTLKK------SL 968
Query: 695 QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER--QALK 752
+ + ++A EA LE N QL++EL+ V + AL+ ++ER Q+
Sbjct: 969 EIKEEKIAALEARLEESTNYN----QQLRQELKTVKK----NYEALKQRQDEERMVQSSP 1020
Query: 753 NALGKAQFSEEKEQENSELHAKLKH-----------LQDDNNLLKQQLKDFQNHLNHVVD 801
G+ E + QE + K+K LQ + LK QLK + N++
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080
Query: 802 GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR--SKWERD 859
++ + + E L+ ++ + + L L Q +++L + S +
Sbjct: 1081 QILALQRQTVSLQEQNTTLQTQNAKLQVE--NSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138
Query: 860 EAQVRERK----LQEEMALQQEKLATGQEEFRQACE-RALEARMNFDKRQH---EARIQQ 911
E+ ++ER+ L + + EKL E RQA E +L ++ K H E +
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHE--RQASEYESLISKHGTLKSAHKNLEVEHRD 1196
Query: 912 MENEIHYLQENLKSMEEIQGLTDLQLQE---ADEEKERILAQLREL-EKKKKLEDAKSQ- 966
+E+ + L + +E+++ + ++ ++ ++ E + A+ ++L + +L SQ
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
Query: 967 ---EQVFGLD-KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE 1014
+V D K LK L AE + K+Q + L T K+N +
Sbjct: 1257 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1308
Score = 77.8 bits (190), Expect = 1e-13
Identities = 146/678 (21%), Positives = 292/678 (43%), Gaps = 95/678 (14%)
Query: 505 VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL 564
V KL L +Q +K+++ I + I+ L D+K +H++ +E
Sbjct: 121 VKKLLLLLLGCAVQCQKKEEFI----ERIQGLDF-----DTKAAVAAHIQEVTHNQENVF 171
Query: 565 DIMNKQYQQLESR-LDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKD----LEGVIS 619
D+ + + ++ +L +A + + D ++ +E I +E ++D L S
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE--ERDGLHFLPHASS 229
Query: 620 GLQEYLGT-----------IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI--V 666
Q G+ + + A+ + R+LR E E ++L + +QE +Q+EI
Sbjct: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 667 AMDAENMRKELAELESALQEQHEVNA------SLQQTQGDLSAYEAELEARLNLRDAEAN 720
+ ENM L++ SA + E++A + + + ++S Y+ L + A
Sbjct: 290 RLQQENMNL-LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH-DIEFYKARVE 347
Query: 721 QLKEE----LEKVTRL-TQLEQSALQA----ELEKERQALKNALGKAQFSEEKEQENSEL 771
+LKE+ LE T L QLE + ++ ELEKE LK L + E E
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL------HDMEMERDMD 401
Query: 772 HAKLKHLQDDN---NLLKQQLKDFQNHLNHVVDGLVRPEEVAA--------RVDEL--RR 818
K++ L ++N + ++Q D HL ++ + R E++ V+EL R
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 819 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878
LKL ++ + L ++ ++ S+IL K E + L+ E+ +++
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQS 520
Query: 879 LATGQEEFRQACER--ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT-DL 935
L Q + + LE + + E +I+ +E E +L + + S+ + ++ +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 936 QLQEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAEL 994
++++ ++E + + ++E K K+E K Q + KEL+ K+ +++L
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQ-----IKKELEHYKEKGERAEELENELH 635
Query: 995 TIAKD-QLKSLHGTVMKINQERAEELQ----EAERFSRKAAQAARDLTRAEAEIELLQNL 1049
+ K+ +L T +KI E+ E L+ E ER +RK + ++E L+
Sbjct: 636 HLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE 695
Query: 1050 LRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGG 1108
Q E+ LE+ + A+ ++ +++ N+ +E ++ ++ + +L K
Sbjct: 696 NSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL-------KAS 747
Query: 1109 FENVLEEIAELRREVSYQ 1126
F+ R EVSYQ
Sbjct: 748 FKKT------ERLEVSYQ 759
Score = 73.9 bits (180), Expect = 2e-12
Identities = 157/777 (20%), Positives = 316/777 (40%), Gaps = 153/777 (19%)
Query: 53 CEQVEIADENNMLLDYQDHK---GADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSK 109
CE++E ++ N L+ ++ K DS + + E+L K+ ++ D NL L +
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE------NLELRR 708
Query: 110 DGGKKFKYIENLEKCVKLEVLNLSYN---LIGKIEKLDKLLKLRELNLSYNKISKIEGIE 166
+ +E+L KC +++ L L + E+L K L+L L S+ K ++E
Sbjct: 709 N-------VESL-KCASMKMAQLQLENKELESEKEQLKKGLEL--LKASFKKTERLE--- 755
Query: 167 NMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILV 226
+ Q L++ ++ KK++ L S LQD+ +
Sbjct: 756 --VSYQGLDIENQRLQKTLENSNKKIQQLE---------SELQDLE-------------M 791
Query: 227 ENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
EN TL L+ + LE LE + + + +E +LE+D KK +E
Sbjct: 792 ENQ--TLQKNLEELKISSKRLEQLEKENKSLE-----------QETSQLEKD--KKQLEK 836
Query: 287 EELKSKQTRFLEE---------IKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQ 337
E + +Q +++ I N +K NK+L +E + K+SC LK EL+K+
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 338 KTIELTRACQKQYELEQELA--------FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
TI++ + +L E K+ + E + +++ D+ +
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEP---DEQLRNDHMNLRGHTPLDTQLEDKEKKI 446
+S+ + + + + A++ + E ++QLR + ++ + Q +D+E+ +
Sbjct: 957 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 447 SAAQTRLSELHDEIEKAEQQILRATEEFK-QLEEAIQLKKISEAGKDLLYKQLSGRLQLV 505
++ +S ++ E+ Q+ R + K +L E + +A K L QL
Sbjct: 1017 QSSPP-ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075
Query: 506 NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP----KHSHMKAQKSGKE 561
N L+ + L L+ Q +++ Q + LQ+ +L+S+ +++ + Q+S E
Sbjct: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Query: 562 QQLDIMNKQYQQLESRLDEILS----------RIAKETEEI-----------KDLEEQLT 600
+ + + K+ + L+S D ++ R A E E + K+LE +
Sbjct: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
Query: 601 EGQIAANEALKK-----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL------ 649
+ + N+ LK+ DLE ++ QE + E +KL E + L
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 650 LQRLTEV-----------------------------EQERDQLEIVAMDAENMRKELAEL 680
L + TEV +++ QL+I + N + L++L
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315
Query: 681 ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
+ L+E++ L Q Q + LE + +D + ++ ++K+ L + ++
Sbjct: 1316 KGNLEEEN--RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 162 bits (409), Expect = 5e-39
Identities = 221/1014 (21%), Positives = 453/1014 (44%), Gaps = 127/1014 (12%)
Query: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNI----DDLLQEKKSLECEVEELHRT 1383
L++ QH++ E RA ++ + E+ + D Q LE ++++L
Sbjct: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416
Query: 1384 VQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLA 1443
V+ ++K L+ +LE EK E E I K L+ +++L A +
Sbjct: 417 VEAADREK-------VELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR--IK 467
Query: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER----RAQETAVNLVK------ 1493
E E L K K + D + + + +S ELE+ R QE A +
Sbjct: 468 ELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKP 527
Query: 1494 ---ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
D L LQ + E+ ++ + + +EI + + + K+ + L +KL
Sbjct: 528 AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKL 587
Query: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL----DRQLGHK 1606
K+ E + +H + + S+V+ K KL++ + S QQ M L + LG +
Sbjct: 588 SKENESLKSKLEHANK--ENSDVIALWK----SKLETAIASHQQAMEELKVSFSKGLGTE 641
Query: 1607 KEELHLLQGSMVQAKADLQEALR-LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISE 1665
E L+ + + + D Q + L + +E+ H +E+++L + +L I E
Sbjct: 642 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL-------RAKLMKVIKE 694
Query: 1666 RKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQ---LENHELQGLKLQHDQR 1722
++ L I+ +++K E+ +H E+++ L+ LQ ++ EL+ L+ + +++
Sbjct: 695 KENSLEAIRSKLDKAED----------QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 744
Query: 1723 VSELEK--TQVAVLEEKL-ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
++ +Q+ EEKL +L+ L++ S + K E++ +Q LE +++I+ + E A
Sbjct: 745 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804
Query: 1780 SCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD 1839
S +++E + + K ++ L++ +V E LE ++ L+++
Sbjct: 805 SKASSITRELQGRELKLTNLQENLSEVSQVK--------------ETLEKELQILKEKFA 850
Query: 1840 QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
+ + + +S+ + +L +K E N L +L ++++L + + ++ L+
Sbjct: 851 EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 910
Query: 1900 EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE- 1958
+ +L+ DI+E D + +L++ + ++EE +LKL + LQK E
Sbjct: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
Query: 1959 ----SEESKLETSKVTLKEQQHQLEKELTDQKSKLD---QVLSKVLAAEERV--RTLQEE 2009
+E+S+ E +K +E++ +LE++L+D + K++ ++ A ER T +
Sbjct: 971 MTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 1029
Query: 2010 ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKA 2069
E ++L+KTL T+ +L ++ EL L+K+AD +A +
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA-------------AQT 1076
Query: 2070 EKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE---LVAQDNHERARRLMKEL 2126
+ + E + ++++ +L + KQ N+ +Q E+ T++ L + +++ L+
Sbjct: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
Query: 2127 NQMQYEY---TELKKQMANQKD-----LERRQMEISDAMRTLKSEV----KDEIRTSLKN 2174
NQ E+ E KQ A QK L+ +++++ + + EV K E S+ N
Sbjct: 1137 NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLN 1196
Query: 2175 LNQFLPELPADLEAILERNENLEGELESLKENLPFT---MNEGPFE-EKLNFSQVHIMDE 2230
NQ L + + I + +E E SL++++ T + E E EKL + E
Sbjct: 1197 -NQLLEMKKRESKFIKDADE----EKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE 1251
Query: 2231 HWRGEALREKLRHRE-DRLKAQLRHCMSKQAEVLIK-GKRQTEGTLHSLRRQVD 2282
+ ++L ++ E D++K +L+ K E+ +K KRQ + + Q D
Sbjct: 1252 NASAKSLHSVVQTLESDKVKLELK---VKNLELQLKENKRQLSSSSGNTDTQAD 1302
Score = 112 bits (279), Expect = 6e-24
Identities = 212/970 (21%), Positives = 397/970 (40%), Gaps = 169/970 (17%)
Query: 196 RVLNLKGNKISSLQDISKL-------KPLQDLISLILVENPVVTLPHYLQFT-IFHLRSL 247
R++ L+ + +Q++++L KP D+ + + + +L L+ T H R +
Sbjct: 500 RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 559
Query: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
SL+ + A E +E++ L EK E E LKSK +E + L
Sbjct: 560 TSLK-------EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW 612
Query: 308 KSLKEEAMLQ-KQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE 366
KS E A+ +Q+ EELK + L +T E EL+ ++ ++D + E
Sbjct: 613 KSKLETAIASHQQAMEELKVSFSKG---LGTETAEFA-------ELKTQIEKMRLDYQHE 662
Query: 367 PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDH 426
N + DS +A K+ME LR
Sbjct: 663 IENLQNQQ-------------------------------DSERAAHAKEMEA---LRAKL 688
Query: 427 MNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKI 486
M + +++KE + A +++L +KAE Q L E+ L K+
Sbjct: 689 MKV---------IKEKENSLEAIRSKL-------DKAEDQHLVEMED--------TLNKL 724
Query: 487 SEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK 546
EA ++ K+L L+ + +Q + I ++K + + LD+
Sbjct: 725 QEA--EIKVKELEV--------------LQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 768
Query: 547 DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA 606
S K++ QQL+ KQ + LE + S+ + T E++ E +LT Q
Sbjct: 769 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 607 NEA--LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
+E +K+ LE + L+E +A Q R +ET+ ++ Q+ +Q
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEASEEAVSVQ------RSMQETV----NKLHQKEEQFN 878
Query: 665 IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE 724
+++ D E +R+ LA++E+ +E+ E L + + L AE+ ++ ++ +
Sbjct: 879 MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938
Query: 725 ELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNL 784
EL RL + + LQ +L K + + L K+ + E S+ A KH +++
Sbjct: 939 EL----RLKERDVEELQLKLTKANEN-ASFLQKSIEDMTVKAEQSQQEAAKKH-EEEKKE 992
Query: 785 LKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQ 844
L+++L D + + E + EL+ + + T E + L +LQ
Sbjct: 993 LERKLSDLEKKM----------ETSHNQCQELKARYERATSETKTKHE-----EILQNLQ 1037
Query: 845 KQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQ--EEFRQACERALEARMNF-- 900
K + + K R+E ++L EE+ Q +K Q E+ Q E+ + +
Sbjct: 1038 KTLLDTEDKLKGAREENSGLLQEL-EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096
Query: 901 ---DKRQHEARIQQMENEIHYLQE-NLKSMEEIQGLTDLQLQEAD--EEKERILAQLREL 954
D +Q A++Q NE+ L+E NLK++EE+ +L E EE + + L++
Sbjct: 1097 SLEDTKQTNAKLQ---NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA 1153
Query: 955 EKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE 1014
+K + + QE+ L +EL + + V + KL E ++ +QL + K ++
Sbjct: 1154 AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL-EEERSVLNNQLLEMKKRESKFIKD 1212
Query: 1015 RAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQV 1074
EE + + + + LT +AE+E L+N + V G N+
Sbjct: 1213 ADEEKASLQ---KSISITSALLTEKDAELEKLRN--------------EVTVLRGENASA 1255
Query: 1075 LEIEKLNETMERQRTEIARLQNVLDLTGSDNK----GGFENVLEEIAELRREVSYQNDYI 1130
+ + +T+E + ++ L+L +NK N + E R Q D++
Sbjct: 1256 KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFL 1315
Query: 1131 SSMADPFKRR 1140
+S+ +R+
Sbjct: 1316 NSVIVDLQRK 1325
Score = 103 bits (258), Expect = 2e-21
Identities = 181/799 (22%), Positives = 351/799 (43%), Gaps = 132/799 (16%)
Query: 430 RGHTPLDTQLEDKEKKISAAQTRLSE--------------LHDEIEKAEQQIL----RAT 471
R L QLE++++K+ Q R+ E H I++ EQ +L +A
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD 481
Query: 472 EEFKQLEEAIQLKKISEAGKDL-LYKQLSGRLQLVNKLRQE------ALDLELQMEKQKQ 524
+ ++LE+ ++ +SE + + L K L+ R+Q V +LR+ A D+++ + Q
Sbjct: 482 KLQRELEDT-RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL-SLLQ 539
Query: 525 EIAGKQKEIK----DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDE 580
EI+ Q++++ D Q I SL H A++ ++++ + ++L +
Sbjct: 540 EISSLQEKLEVTRTDHQREITSL------KEHFGAREETHQKEIKALYTATEKLSKENES 593
Query: 581 ILSRIA---KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
+ S++ KE ++ L + E IA+++ ++L+ S + LGT + + +
Sbjct: 594 LKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS---KGLGTETAEFAELKT 650
Query: 638 ECRKLRDEKETLLQRL------------TEVEQERDQLEIVAMDAENMRKELAELESALQ 685
+ K+R + + ++ L E+E R +L V + EN + + +
Sbjct: 651 QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 710
Query: 686 EQH--EVNASLQQTQ------GDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
+QH E+ +L + Q +L +A+ + + D +QLK EK+ L L +
Sbjct: 711 DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770
Query: 738 SALQ--AELEKERQALKNALGKAQFSE-EKEQENSELHA----------KLKHLQDDNNL 784
++ + +E++K RQ L+ A + + E EK E+S+ + KL +LQ++ +
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 785 LKQQLKDFQNHLNHVVDGLVRPEEVAARV----DELRRKLKLGTGEMN-IHSPSDVLGKS 839
+ Q + + L + + E A V E KL + N + S + L ++
Sbjct: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 890
Query: 840 LADLQKQFSEILARSKWERDEAQVR-ERKLQEEMALQQEKLATGQEEFRQACERALEARM 898
LAD++ +F R K ER+E ++ + KL+ ++A + + +M
Sbjct: 891 LADMEAKF-----REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL---------TKM 936
Query: 899 NFDKRQHEARIQQMENEIHYLQENL----KSMEEIQGLTDLQLQEA----DEEKERILAQ 950
N + R E +++++ ++ EN KS+E++ + QEA +EEK+ + +
Sbjct: 937 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK 996
Query: 951 LRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMK 1010
L +LEKK + + QE K + ATS+ T I ++ K+L T K
Sbjct: 997 LSDLEKKMETSHNQCQE---------LKARYERATSE-TKTKHEEILQNLQKTLLDTEDK 1046
Query: 1011 INQERAEE---LQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF-RLEMEK--- 1063
+ R E LQE E RK A A+ AE +++++ + ++K E LE K
Sbjct: 1047 LKGAREENSGLLQELEEL-RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1105
Query: 1064 ----TGVGTGANSQVLEIEKLNE-----TMERQRTEIARLQ-NVLDLTGSDNKGGFENVL 1113
+ T + + +E+LN+ T+E Q+ E R + L + +
Sbjct: 1106 AKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1165
Query: 1114 EEIAELRREVSYQNDYISS 1132
EE +L E+ D ++S
Sbjct: 1166 EENVKLAEELGRSRDEVTS 1184
Score = 99.0 bits (245), Expect = 5e-20
Identities = 160/755 (21%), Positives = 328/755 (43%), Gaps = 128/755 (16%)
Query: 1658 ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKL 1717
E + + + + + T +++ +++++++++ +L + + E+ + EL +
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
Query: 1718 QHDQRVSELE--------------KTQVAVL----EEKLELENLQQISQQQ---KGEIEW 1756
HDQ V ELE + +V +L EEK ++E+LQ +++ KG++E
Sbjct: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLET 457
Query: 1757 QKQLLERDKREIERMTAESRALQSCVECLSKEKED-----LQEKCDIWEKKLAQTKRVLA 1811
Q +L +E+E+ + + + L +E ED + EK I E + RV
Sbjct: 458 QTKLEHARIKELEQSLLFEK---TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQE 514
Query: 1812 AAEENSKMEQ-----------SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
AE ++E S L+++ KL+ R+ SL A ++ Q
Sbjct: 515 VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ 574
Query: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTK-HQDVLLSEQTRLQKDISEWANRFEDCQ 1919
++ +A+ + E+L+ + L K L H K + DV+ +++L+ I+ E+ +
Sbjct: 575 KEIKALYTATEKLSKENESL---KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK 631
Query: 1920 ----KEEETKQQQLQVLQNEIEENKLKLVQQ-EMMFQRLQKERESEESKLETSKVTLKEQ 1974
K T+ + L+ +IE+ +L + E + + ER + ++E + L +
Sbjct: 632 VSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKV 691
Query: 1975 QHQLEKELTDQKSKLDQ-----------VLSKVLAAEERVRTLQEEERWCESLEKTLSQT 2023
+ E L +SKLD+ L+K+ AE +V+ L+ + C K +
Sbjct: 692 IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF 751
Query: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK------ 2077
QL E++L+ +L AL+K + +++ LR Q + AEKQ+ L+
Sbjct: 752 TSQLKATEEKLL----DLDALRKASSEGKSEMKKLRQQL----EAAEKQIKHLEIEKNAE 803
Query: 2078 -----------EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA---RRLM 2123
+ +++ + L++NL E Q ++KE+ ++ + E A +R M
Sbjct: 804 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 863
Query: 2124 KE----LNQMQYEY----TELKKQMANQKDLE-------RRQMEISDAMRTLKSEVKDEI 2168
+E L+Q + ++ ++L+K N D+E R+ ++ A L++++ + +
Sbjct: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM 2228
+ S N +Q L ++ +L L+ + E +L+ K N E +F Q I
Sbjct: 924 KMSGDNSSQ-LTKMNDELR--LKERDVEELQLKLTKAN-----------ENASFLQKSIE 969
Query: 2229 DEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
D + E +++ + + K +L +S ++ K +T H+ +++ A E
Sbjct: 970 DMTVKAEQSQQEAAKKHEEEKKELERKLSD-----LEKKMETS---HNQCQELKARYERA 1021
Query: 2289 TSTSADSASSPSLSQLESSL--TEDSQLGQNQEKN 2321
TS + L L+ +L TED G +E +
Sbjct: 1022 TS-ETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055
Score = 87.8 bits (216), Expect = 1e-16
Identities = 151/664 (22%), Positives = 276/664 (41%), Gaps = 120/664 (18%)
Query: 556 QKSGKEQQLDIMNKQYQQLESR------LDEILSRIAKETEEIKDLEEQLTEGQIAANEA 609
++S L M+ + SR L E SR A++ L+E L E Q +
Sbjct: 308 KRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQL 367
Query: 610 L-KKDLEGV-ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
L ++DLE ++ ++G I+ + A RD + Q + E+E + DQL +
Sbjct: 368 LAERDLERAEVAKATSHVGEIEQELALA-------RDGHD---QHVLELEAKMDQLRTMV 417
Query: 668 MDAENMRKELA-ELESALQEQHEVNASLQQ---TQGDLS-------AYEAELEARLNLRD 716
A+ + EL +LE ++ ++ +++ T+GDL A ELE L
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477
Query: 717 AEANQLKEELEKVTRLTQLEQSALQAELEKE-------------RQALKNALGKAQFSEE 763
+A++L+ ELE TR+ + + + ELEK+ R G S
Sbjct: 478 TKADKLQRELED-TRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 536
Query: 764 KEQENSELHAKLKHLQDDNNLLKQQLKDF-----QNHLNHVVDGLVRPEEVAARVDELRR 818
QE S L KL+ + D+ LK+ + H + E+++ + L+
Sbjct: 537 LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS 596
Query: 819 KLKLGTGEMNIHSPSDVLG--------------KSLADLQKQFSEILARSKWERDEAQVR 864
KL+ E SDV+ +++ +L+ FS+ L E E + +
Sbjct: 597 KLEHANKE-----NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651
Query: 865 ERKLQEEMALQQEKLATGQEEFRQACERALEA-------------------RMNFDKRQH 905
K++ + + E L Q+ R A + +EA R DK +
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE- 710
Query: 906 EARIQQMENEIHYLQE---NLKSMEEIQGLTDLQLQ---------EADEEKERILAQLRE 953
+ + +ME+ ++ LQE +K +E +Q + Q + +A EEK L LR+
Sbjct: 711 DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770
Query: 954 LEKKKKLEDAKSQEQVFGLDKELKKL---KKAVATSDKLATAELTIAKDQLKSLHGTVMK 1010
+ K E K ++Q+ +K++K L K A ++ T EL + +L +L + +
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 1011 INQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRL---EMEKTGVG 1067
++Q + +E + K A+A+ + + ++ N L QK EQF + ++EK
Sbjct: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK---- 886
Query: 1068 TGANSQVLEIE-KLNETMERQRTEI---ARLQN----VLDLTGSDNKGGFENVLEEIAEL 1119
+ ++E K E ER+ I +L+N ++ ++G DN + +E+
Sbjct: 887 --LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-DNSSQLTKMNDELRLK 943
Query: 1120 RREV 1123
R+V
Sbjct: 944 ERDV 947
Score = 84.7 bits (208), Expect = 9e-16
Identities = 102/514 (19%), Positives = 230/514 (44%), Gaps = 74/514 (14%)
Query: 1311 LHCNVPEHHNLENEVSRLEDIMQHLKSKKRE----ERWMRASKRQSEKEMEELHHNIDD- 1365
LH + + L +++ +L + + +++K RE E + +K + E ++ E+ D
Sbjct: 870 LHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDN 929
Query: 1366 ------LLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI--EKSLKHHEDI 1417
+ E + E +VEEL + K + F+ ++E + + E +++ K HE+
Sbjct: 930 SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE- 988
Query: 1418 VDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDA 1477
E +E +R L++ E ++ + + + ++ +R+ +T++
Sbjct: 989 ----------------EKKELERKLSDLEKKMETSHNQCQELKARY---ERATSETKTKH 1029
Query: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSD--FQC 1535
EE+ + Q+T L+ + +L+ + + L Q + EE+ K+ +K AA+ ++ Q
Sbjct: 1030 EEILQNLQKT---LLDTEDKLKGAREENSGLLQ---ELEELRKQADKAKAAQTAEDAMQI 1083
Query: 1536 LSKKKEKLTEELQ----------KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1585
+ + ++ TE L KLQ +++ + N +++ L +S+ LL + ++E+
Sbjct: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEF 1143
Query: 1586 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV 1645
+ ++ + +Q A +QL +EE L E L EVT
Sbjct: 1144 RKEIETLKQAAAQKSQQLSALQEE-----------NVKLAEELGRSRDEVTSH------- 1185
Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
++L ++ LN Q+ E K + + ++ ++E+ +LQ + S TE L+ L
Sbjct: 1186 ----QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1241
Query: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765
+ E L+G S ++ + ++ +L+++NL+ ++ K ++ +
Sbjct: 1242 RNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1301
Query: 1766 REIER-MTAESRALQSCVECLSKEKEDLQEKCDI 1798
E ER ++ L S + L ++ +DL+ K ++
Sbjct: 1302 DEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEM 1335
Score = 54.3 bits (129), Expect = 1e-06
Identities = 111/578 (19%), Positives = 236/578 (40%), Gaps = 64/578 (11%)
Query: 54 EQVEIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTK-QDNLALIKSLNLSLSKDGG 112
+Q+E A++ L+ + + + + + + KLT Q+NL+ + + +L K+
Sbjct: 784 QQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 843
Query: 113 -KKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNL 171
K K+ E E+ V ++ ++ + KL + K + N+ + + K+ EN+ ++
Sbjct: 844 ILKEKFAEASEEAVSVQ-----RSMQETVNKLHQ--KEEQFNMLSSDLEKLR--ENLADM 894
Query: 172 QKLNLAGNEIEHIPVWLGKKLKS--LRVLNLKGNKISSLQDISKLKPLQDLISLILVENP 229
+ +E E + +KL++ ++ + G+ S L ++ L++ VE
Sbjct: 895 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD----VEEL 950
Query: 230 VVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLE--EVERLERDLEKKM---- 283
+ L + F +S+E + + Q +QEA ++ E E+ER DLEKKM
Sbjct: 951 QLKLTKANENASFLQKSIEDMTVK--AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008
Query: 284 IETEELKSKQTRFLEEIK----------------NQDKLNKSLKEEAMLQKQSCEELKSD 327
+ +ELK++ R E K +DKL K +EE Q EEL+
Sbjct: 1009 NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL-KGAREENSGLLQELEELRKQ 1067
Query: 328 LNTKN---------ELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEI 378
+ ++++Q T E T + +Q A K+ + + L + +
Sbjct: 1068 ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA--KLQNELDTLK--ENNLKNV 1123
Query: 379 DKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQ 438
++ + K F E I++ + +K + L+ +++ L
Sbjct: 1124 EELNKSKELLTVENQKMEEFRKE---IETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180
Query: 439 LEDKEKKISAAQTRLSELHDEIEKAEQQILR-ATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
+K+ ++ L+ E++K E + ++ A EE L+++I + KD ++
Sbjct: 1181 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK 1240
Query: 498 LSGRLQLVNKLRQEALDLE-----LQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSH 552
L + ++ A L L+ +K K E+ K E++ + S +
Sbjct: 1241 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1300
Query: 553 MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
+ +E Q+D +N L+ + ++ ++ +E
Sbjct: 1301 ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
Score = 48.1 bits (113), Expect = 1e-04
Identities = 80/345 (23%), Positives = 145/345 (42%), Gaps = 43/345 (12%)
Query: 244 LRSLESLEGQP------VTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFL 297
L+ LE L Q T +D + E+ + E+ E L + K + T
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 298 EEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQEL- 356
+KN ++LNKS KE ++ Q EE + ++ T + QK+ +L+ ++ +L +EL
Sbjct: 1118 NNLKNVEELNKS-KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1176
Query: 357 -------AFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409
+ K++ + LN ++ E+ K ES +I + ++ A+ I
Sbjct: 1177 RSRDEVTSHQKLEEERSVLN---NQLLEMKKR--ESKFIKDADEEK---ASLQKSISITS 1228
Query: 410 AVQIKKMEPDEQLRNDHMNLRG--------HTPLDTQLEDK---EKKISAAQTRLSELHD 458
A+ +K E+LRN+ LRG H+ + T DK E K+ + +L E
Sbjct: 1229 ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1288
Query: 459 EIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL----- 513
++ + +E ++ +E+ Q+ ++ DL K +++ V + + AL
Sbjct: 1289 QLSSSSGNTDTQADEDERAQES-QIDFLNSVIVDLQRKNQDLKMK-VEMMSEAALNGNGD 1346
Query: 514 DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKS 558
DL + QE K+K I D D D + +AQ S
Sbjct: 1347 DLN-NYDSDDQEKQSKKKPRLFCDIC-DCFDLHDTEDCPTQAQMS 1389
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 161 bits (408), Expect = 6e-39
Identities = 230/1064 (21%), Positives = 468/1064 (43%), Gaps = 134/1064 (12%)
Query: 1321 LENEVSRLEDIMQHLK-------SKKREERWMRASKRQSEKEMEELHHNIDDLLQ-EKKS 1372
LE+EVSR ++ + ++ K + + + +K E ++E D L + EK++
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMT-ELEIEKSLKHHEDIVDEIECIEKTLLKR 1431
L+ + + LH +R + I+ +E MT E+ ++S+ + E+E I +T
Sbjct: 385 LQLKAK-LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT---- 439
Query: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
SEL EA + E E T + + K +SL +T + + A +
Sbjct: 440 -SELSEAPQKSLGHE-----VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
Query: 1492 VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
+K +++ + L K+ EIL+ N+IV K S C + K+ + E+ Q L+
Sbjct: 494 LKMEKENQRLS-----------KKVEILE--NEIVQEKQSLQNCQNLSKDLMKEKAQ-LE 539
Query: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ------QQEMAVLDRQLGH 1605
K IE N + +++L++ L + L + +SQ++++ ++E +L +
Sbjct: 540 KTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAEARVKDIEKENKILHESIKE 598
Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGET--EVTEKCNHIREVKSLLEELSFQKGELNVQI 1663
+L ++ Q K +L+ GE E+ + +H+ + LL QK N++I
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL-----QKKITNLKI 653
Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGLKLQHD 1720
+ K + +E+E L+ R++ K KN+ L+ L+ EN +L L+
Sbjct: 654 TCEKIEA------LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 1721 QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
+ V L+ + + + +LE + L+ +Q K +E K ++ +R L+
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER-----------LEV 756
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK------- 1833
+ L E + LQ+ + KK+ Q + L E ++ Q NLE+L+++ ++
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 1834 ---LQQELDQLNRDKLSLHNDISAMQQQ-------LQEKREAVNSLQEELANVQDHLNLA 1883
L+QE QL +DK L + ++QQ L+E + +L++E + + +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQ---QLQVLQNEIEE-- 1938
K+ + + + R DI ED E+ QQ L+ L +E+E+
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 1939 -NKLKLVQQEM-----MFQRLQKERESEESK-LETSKVTLKEQQHQLEKELTDQKSKLDQ 1991
NK +L+ E ++ L+ + ES K LE + + + +LE E T+ +L Q
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQLRQ 995
Query: 1992 VLSKVLAAEERVRTLQEEERWCES---LEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
L V E ++ Q+EER +S + ++ +R+ E ++L++ L+ +++
Sbjct: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
+++A+ L+ Q KQ+ + L+ Q L++ + +++N+ +Q + A +
Sbjct: 1056 ATLQAEKQALKTQL--------KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1107
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQ----MANQKDL---------ERRQMEISD 2155
++ + ++ LM + Q+ + + L+ + + ++DL + ++E+
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167
Query: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGP 2215
+ + E +LK+ ++ L DLE + +G+LE L++ L +
Sbjct: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1227
Query: 2216 FEEKLNFSQVHIMDEHWRGEALREKLRHREDRL--KAQLRHCMSKQAEVLIKGKR----Q 2269
E K N V + GE ++L H +L + ++ K + L+ + +
Sbjct: 1228 LENK-NHETVAAEYKKLCGE--NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR 1284
Query: 2270 TEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQ 2313
E L+ Q L +TST ++ LSQL+ +L E+++
Sbjct: 1285 LEAEFSKLKEQYQQLD--ITSTKLNN-QCELLSQLKGNLEEENR 1325
Score = 144 bits (362), Expect = 1e-33
Identities = 198/942 (21%), Positives = 420/942 (44%), Gaps = 109/942 (11%)
Query: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
+KR + LA+A++++ +++ + E+ D K+ L Q E + +R Q+
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL----KRLQQEN 295
Query: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
+NL+ + R + + L + ++ +++ E+++ + D + + E+L E+ Q
Sbjct: 296 MNLLSDARSARMYRDELDALREKAVRVDKLESEVSR-YKERLHDIEFYKARVEELKEDNQ 354
Query: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
L + M E E K ELEK Q+ ++ +M ++R + KK
Sbjct: 355 VLLETKTMLEDQ--------LEGTRARSDKLHELEKENLQLKAKLHDME-MERDMDRKKI 405
Query: 1609 ELHLLQGSM---VQAKADLQEALRLG-ETEVTEKCNHIREVKSLLEELSFQKGELNVQIS 1664
E L++ +M + K + E+L LG E E + + + E + L + EL
Sbjct: 406 E-ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ--KSLGHEVNEL----- 457
Query: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
T L+K E+E + ++K EL+ +D ++ ++ ++ ++ +
Sbjct: 458 ---TSSRLLKLEMENQ---------SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505
Query: 1725 ELEKTQVAVLEEKLELENLQQISQ---QQKGEIEWQ-KQLLERDKREIERMTAESRALQS 1780
++E + +++EK L+N Q +S+ ++K ++E + L E +R+I+ + E+ L
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
V L ++ Q + K + + ++L E+ K S L K+E R++++EL+
Sbjct: 566 TVSSL---RQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEH 619
Query: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
++K ++ L+++ E LQ+++ N L + + + + L E
Sbjct: 620 Y-KEKGERAEELENELHHLEKENEL---LQKKITN----LKITCEKIEALEQENSELERE 671
Query: 1901 QTRLQKDISEWAN---RFEDCQKEEETKQQQLQVLQNEIEENK---LKLVQQEMMFQRLQ 1954
+L+K + + N + E +KE ++ L+ +E K +K+ Q ++ + L+
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 1955 KERESEESKLETSKVTLKE-------------QQHQLEKELTDQKSKLDQVLSKVLAAEE 2001
E+E + LE K + K+ + +L+K L + K+ Q+ S++ E
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 2002 RVRTLQE-------EERWCESLE---KTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
+TLQ+ + E LE K+L Q QL + ++QL +++ L + D+
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 2052 RADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELV 2111
+ ++ E K K++ KE+ ++ +LEK E + + K + T+
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESC-VRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 2112 AQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDA-MRTLKSEVKDEIRT 2170
+ +++ +L ++ + EL+K N++ L + D+ + L+S+++ ++
Sbjct: 911 LVSEKLKTQQMNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967
Query: 2171 SLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIM-- 2228
SL+ + + L A LE N+ L EL+++K+N + + EE++ S I
Sbjct: 968 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGE 1026
Query: 2229 DEHWRGEA---LREKLRHRE-----DRLKAQL---RHCMSKQAEVLIKGKRQTEGTLHSL 2277
D W E+ RE L+ ++ +R A L + + Q + L + + +L
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
Query: 2278 RRQVDALGELVTSTSADSA-----SSPSLSQLESSLTEDSQL 2314
+RQ +L E T+ +A +S SQ S + +++QL
Sbjct: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Score = 124 bits (311), Expect = 1e-27
Identities = 189/876 (21%), Positives = 380/876 (43%), Gaps = 106/876 (12%)
Query: 1318 HHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
H +++ S+L I + K+E + K + E+ EEL + + L +E + L+ ++
Sbjct: 593 HESIKETSSKLSKIEFEKRQIKKE---LEHYKEKGERA-EELENELHHLEKENELLQKKI 648
Query: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELRE 1437
L T +K + + N E +++K+L +++ ++E +E K S+L E
Sbjct: 649 TNLKITCEKIEALE---QENSELERENRKLKKTLDSFKNLTFQLESLE----KENSQLDE 701
Query: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD-Q 1496
+ L L C K + LQ E+ E E+ + + L+KA +
Sbjct: 702 ENLELRRNVESLKC------------ASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
+ L+ + L+ + ++ L+ NK + +S+ Q L + + L + L++L
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL------ 803
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616
+ L+ L++ L+ + ++LEK K Q+ + + + EE ++ G+
Sbjct: 804 --KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ----ISERKTQLTL 1672
+ + L + + + E C ++E++ +EL ++ ++++ + E L
Sbjct: 862 LEKENKTLSKEIGI----YKESCVRLKELEKENKEL-VKRATIDIKTLVTLREDLVSEKL 916
Query: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS-ELEKTQV 1731
Q++ + E L L ++ +K L + ++L KL+ + S E+++ ++
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976
Query: 1732 AVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
A LE + LE +QQ + E++ K+ E K+ + E R +QS ++ +
Sbjct: 977 AALEAR--LEESTNYNQQLRQELKTVKKNYEALKQRQD----EERMVQSSPPISGEDNK- 1029
Query: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
WE++ +T R L ++ + N L+ + L+ +L QL +L
Sbjct: 1030 -------WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 1852 ISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911
I A+Q+Q +E +LQ + A +Q + LL +Q+ L+
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE------ 1136
Query: 1912 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
N E KE E L+ L + + ++ KL E++ +R E ES SK TL
Sbjct: 1137 -NENESVIKERE----DLKSLYDSLIKDHEKL---ELLHERQASEYESLISK----HGTL 1184
Query: 1972 KEQQHQLEKELTDQKSKLDQVLSKVLAAE--ERVRTLQEEERWCESL-EKTLSQTKRQLS 2028
K LE E D + + +Q+L + E E++ +++E+ E+ +T++ ++L
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244
Query: 2029 EREQQLVEKSGELLALQKEADSMRADF----SLLRNQFLTERKKAEKQVASLKEALKIQR 2084
+L +LL KE + ++ D SLL N L E+ + E + + LKE Q
Sbjct: 1245 GENDRLNHTYSQLL---KETEVLQTDHKNLKSLLNNSKL-EQTRLEAEFSKLKE----QY 1296
Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQMQYEYTELKKQMA 2141
QL+ + K N C EL++Q + E R L+ ++ + + L +Q
Sbjct: 1297 QQLD--ITSTKLNNQC--------ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1346
Query: 2142 NQKDL----ERRQMEISDAMRTLKSEVKDEIRTSLK 2173
KDL +R+ ++ + +R K +++++I K
Sbjct: 1347 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1382
Score = 107 bits (267), Expect = 1e-22
Identities = 159/790 (20%), Positives = 344/790 (43%), Gaps = 139/790 (17%)
Query: 445 KISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL-- 502
+++ A+ ++ L E+E+ +Q+L +E +Q+E I+LK++ + +LL S R+
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQME--IELKRLQQENMNLLSDARSARMYR 309
Query: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
++ LR++A ++++K + E++ ++ + D++ ++ + + K+ E
Sbjct: 310 DELDALREKA----VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 563 QLD----------IMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK 612
QL+ + K+ QL+++L ++ + ++I++L E+ ++A +++ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 613 DL------------EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660
L + Q+ LG + T ++ KL E ++L + + E+
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR--LLKLEMENQSLTKTVEELRTTV 483
Query: 661 DQLE-----IVAMDAENMR--KELAELESALQEQHEVNASLQQTQGDLSAYEAEL----- 708
D +E I+ M+ EN R K++ LE+ + ++ + + Q DL +A+L
Sbjct: 484 DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
Query: 709 ------EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL-------KNAL 755
E ++ + + E L + + + + +Q+ A ++EKE + L + L
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 756 GKAQFS-----------EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLV 804
K +F +EK + EL +L HL+ +N LL++++ +L + +
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI----TNLKITCEKIE 659
Query: 805 RPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEI------------- 850
E+ + ++ RKLK N+ + L K + L ++ E+
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
Query: 851 LARSKWERDEAQVRERKLQEEMAL------QQEKLATGQEEFRQACERALEARMNFDKR- 903
+A+ + E E + + +L++ + L + E+L + +R + N +K+
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
Query: 904 -QHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
Q E+ +Q +E E LQ+NL+ ++ ++ +L++ ++E + + + +LEK KK
Sbjct: 780 QQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKK--- 832
Query: 963 AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMK---INQERAEEL 1019
L+KE K+L++ D E + L+ + T+ K I +E L
Sbjct: 833 --------QLEKENKRLRQQAEIKD-TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL 883
Query: 1020 QEAERFSRKAAQAARDLTRAEAEIELLQNLL------RQKGEQFRLEMEKTGVGTGANSQ 1073
+E E+ +++ + RA +I+ L L + K +Q ++EK
Sbjct: 884 KELEKENKELVK------RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL--------- 928
Query: 1074 VLEIEKLNETMER-----QRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQND 1128
E+EK+ ER Q T+ +R + + S K E E+IA L + +
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988
Query: 1129 YISSMADPFK 1138
Y + K
Sbjct: 989 YNQQLRQELK 998
Score = 107 bits (266), Expect = 2e-22
Identities = 205/964 (21%), Positives = 407/964 (42%), Gaps = 158/964 (16%)
Query: 260 RQEAFERFSLE------EVERLERDLEKKM--------------IETEELKSKQTRFLEE 299
R E+ + S+E ++ RL ++LE+K IE + L+ + L +
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 300 IKN----QDKLNKSLKEEAM--------------------LQKQSCEELKSD----LNTK 331
++ +D+L+ +L+E+A+ K EELK D L TK
Sbjct: 302 ARSARMYRDELD-ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 332 NELLKQKTIELTRA-CQKQYELEQELAFYKI---------DAKFEPLNYYPSEYAEIDKA 381
L Q +E TRA K +ELE+E K D + + E ++ A
Sbjct: 361 TMLEDQ--LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 382 P----DESPYIG--KSRYKRNMFATES------YIIDSAQAVQIKKMEPD--------EQ 421
DES ++G + R +E+ + ++ + ++ K+E + E+
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 422 LRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL-EEA 480
LR ++ G+ ++E + +++S ++ L +EI + +Q + K L +E
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLS---KKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 481 IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ--- 537
QL+K E ++ +Q+ + + E L+ + +Q+ +I+ + + +KD++
Sbjct: 536 AQLEKTIETLRENSERQIK-----ILEQENEHLNQTVSSLRQRSQISAEAR-VKDIEKEN 589
Query: 538 -IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE--EIKD 594
I +S+ K S ++ +K +++L+ ++ ++ E L+ L + KE E + K
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKI 648
Query: 595 LEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLT 654
++T +I A E +LE L++ L + K Q ++ L E L +
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENL 704
Query: 655 EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNL 714
E+ + + L+ +M ++ E ELES E+ ++ L+ + E LE
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELES---EKEQLKKGLELLKASFKKTE-RLEVSYQG 760
Query: 715 RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK---------- 764
D E +L++ LE + Q +S LQ +LE E Q L+ L + + S ++
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQ-DLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 765 -EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLG 823
EQE S+L K L+ +N L+QQ + L EE ++ L ++ K
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL----------EENNVKIGNLEKENKTL 869
Query: 824 TGEMNIHSPSDVLGKSLADLQKQFSEILARSKWE-RDEAQVRERKLQEEMALQQ-----E 877
+ E+ I+ S V L +L+K+ E++ R+ + + +RE + E++ QQ E
Sbjct: 870 SKEIGIYKESCV---RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
Query: 878 KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQL 937
KL E+ ER L + D +++ ++E+ L+++L+ EE + +L
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST---LKKSLEIKEEKIAALEARL 983
Query: 938 QEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTI 996
+E+ +++ +L+ ++K + L+ + +E++ + + T EL
Sbjct: 984 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1043
Query: 997 AKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
KD+L +++ + A E + + Q +A+I LQ EQ
Sbjct: 1044 VKDRL-------IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
Query: 1057 FRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEI 1116
T +Q +++ N T+ Q T + L + S + E+V++E
Sbjct: 1097 ----------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1146
Query: 1117 AELR 1120
+L+
Sbjct: 1147 EDLK 1150
Score = 104 bits (260), Expect = 9e-22
Identities = 189/832 (22%), Positives = 349/832 (41%), Gaps = 121/832 (14%)
Query: 265 ERFSLEEVERLERDLEK------KMIET-EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
E+ SL+ + L +DL K K IET E +Q + LE+ + LN+++
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ--ENEHLNQTVSSLRQRS 574
Query: 318 KQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE 377
+ S E D+ +N++L + E + K + F K K E L +Y +
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSK-------IEFEKRQIKKE-LEHYKEKGER 626
Query: 378 IDKAPDESPYIGKSRYKRNMFATESYII-DSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
++ +E ++ K T I + +A++ + E + + R L L
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
Query: 437 TQLEDKEKKISAAQTRLSELHDEIEK---AEQQILRATEEFKQLE-EAIQLKK------- 485
QLE EK+ S EL +E A ++ + E K+LE E QLKK
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 486 ---------ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL 536
+S G D+ ++L L+ NK Q+ LE +++ + E QK +++L
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ---LESELQDLEMENQTLQKNLEEL 803
Query: 537 QIAIDSLDSKDPKHSHMKAQKSGKEQ---QLDIMNKQYQQ----LESRLDEILSRIAKET 589
+I+ L+ + ++ ++ + S E+ QL+ NK+ +Q ++ L+E +I
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 590 EEIKDLEEQL---TEGQIAANEALKKDLEGV---------ISGLQEYLGTIKGQATQAQN 637
+E K L +++ E + E K++ E V + L+E L + K + Q N
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 638 ECRKLRDEKETL---LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
+ KL E E + +RL EQ D ++ ++LES L++ SL
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE--------SKLESTLKK------SL 969
Query: 695 QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER--QALK 752
+ + ++A EA LE N QL++EL+ V + AL+ ++ER Q+
Sbjct: 970 EIKEEKIAALEARLEESTNYN----QQLRQELKTVKK----NYEALKQRQDEERMVQSSP 1021
Query: 753 NALGKAQFSEEKEQENSELHAKLKH-----------LQDDNNLLKQQLKDFQNHLNHVVD 801
G+ E + QE + K+K LQ + LK QLK + N++
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1081
Query: 802 GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR--SKWERD 859
++ + + E L+ ++ + + L L Q +++L + S +
Sbjct: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVE--NSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 860 EAQVRERK----LQEEMALQQEKLATGQEEFRQACE-RALEARMNFDKRQH---EARIQQ 911
E+ ++ER+ L + + EKL E RQA E +L ++ K H E +
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHE--RQASEYESLISKHGTLKSAHKNLEVEHRD 1197
Query: 912 MENEIHYLQENLKSMEEIQGLTDLQLQE---ADEEKERILAQLREL-EKKKKLEDAKSQ- 966
+E+ + L + +E+++ + ++ ++ ++ E + A+ ++L + +L SQ
Sbjct: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
Query: 967 ---EQVFGLD-KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE 1014
+V D K LK L AE + K+Q + L T K+N +
Sbjct: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309
Score = 77.8 bits (190), Expect = 1e-13
Identities = 146/678 (21%), Positives = 292/678 (43%), Gaps = 95/678 (14%)
Query: 505 VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQL 564
V KL L +Q +K+++ I + I+ L D+K +H++ +E
Sbjct: 121 VKKLLLLLLGCAVQCQKKEEFI----ERIQGLDF-----DTKAAVAAHIQEVTHNQENVF 171
Query: 565 DIMNKQYQQLESR-LDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKD----LEGVIS 619
D+ + + ++ +L +A + + D ++ +E I +E ++D L S
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE--ERDGLHFLPHASS 229
Query: 620 GLQEYLGT-----------IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI--V 666
Q G+ + + A+ + R+LR E E ++L + +QE +Q+EI
Sbjct: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 667 AMDAENMRKELAELESALQEQHEVNA------SLQQTQGDLSAYEAELEARLNLRDAEAN 720
+ ENM L++ SA + E++A + + + ++S Y+ L + A
Sbjct: 290 RLQQENMNL-LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH-DIEFYKARVE 347
Query: 721 QLKEE----LEKVTRL-TQLEQSALQA----ELEKERQALKNALGKAQFSEEKEQENSEL 771
+LKE+ LE T L QLE + ++ ELEKE LK L + E E
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL------HDMEMERDMD 401
Query: 772 HAKLKHLQDDN---NLLKQQLKDFQNHLNHVVDGLVRPEEVAA--------RVDEL--RR 818
K++ L ++N + ++Q D HL ++ + R E++ V+EL R
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 819 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878
LKL ++ + L ++ ++ S+IL K E + L+ E+ +++
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQS 520
Query: 879 LATGQEEFRQACER--ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT-DL 935
L Q + + LE + + E +I+ +E E +L + + S+ + ++ +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 936 QLQEADEEKERILAQLRELEKK-KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAEL 994
++++ ++E + + ++E K K+E K Q + KEL+ K+ +++L
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQ-----IKKELEHYKEKGERAEELENELH 635
Query: 995 TIAKD-QLKSLHGTVMKINQERAEELQ----EAERFSRKAAQAARDLTRAEAEIELLQNL 1049
+ K+ +L T +KI E+ E L+ E ER +RK + ++E L+
Sbjct: 636 HLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE 695
Query: 1050 LRQKGEQFRLEMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGG 1108
Q E+ LE+ + A+ ++ +++ N+ +E ++ ++ + +L K
Sbjct: 696 NSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL-------KAS 747
Query: 1109 FENVLEEIAELRREVSYQ 1126
F+ R EVSYQ
Sbjct: 748 FKKT------ERLEVSYQ 759
Score = 75.1 bits (183), Expect = 7e-13
Identities = 159/778 (20%), Positives = 318/778 (40%), Gaps = 154/778 (19%)
Query: 53 CEQVEIADENNMLLDYQDHK---GADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSK 109
CE++E ++ N L+ ++ K DS + + E+L K+ ++ D NL L +
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE------NLELRR 708
Query: 110 DGGKKFKYIENLEKCVKLEVLNLSYN---LIGKIEKLDKLLKLRELNLSYNKISKIEGIE 166
+ +E+L KC +++ L L + E+L K L+L L S+ K ++E
Sbjct: 709 N-------VESL-KCASMKMAQLQLENKELESEKEQLKKGLEL--LKASFKKTERLE--- 755
Query: 167 NMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILV 226
+ Q L++ ++ KK++ L S LQD+ +
Sbjct: 756 --VSYQGLDIENQRLQKTLENSNKKIQQLE---------SELQDLE-------------M 791
Query: 227 ENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET 286
EN TL L+ + LE LE + + + +E +LE+D KK +E
Sbjct: 792 ENQ--TLQKNLEELKISSKRLEQLEKENKSLE-----------QETSQLEKD--KKQLEK 836
Query: 287 EELKSKQTRFLEE---------IKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQ 337
E + +Q +++ I N +K NK+L +E + K+SC LK EL+K+
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 338 KTIELTRACQKQYELEQELA--------FYKIDAKFEPLNYYPSEYAEIDKAPDESPY-I 388
TI++ + +L E K+ + E + +++ D+S Y +
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEP---DEQLRNDHMNLRGHTPLDTQLEDKEKK 445
+S+ + + + + A++ + E ++QLR + ++ + Q +D+E+
Sbjct: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
Query: 446 ISAAQTRLSELHDEIEKAEQQILRATEEFK-QLEEAIQLKKISEAGKDLLYKQLSGRLQL 504
+ ++ +S ++ E+ Q+ R + K +L E + +A K L QL
Sbjct: 1017 VQSSPP-ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
Query: 505 VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP----KHSHMKAQKSGK 560
N L+ + L L+ Q +++ Q + LQ+ +L+S+ +++ + Q+S
Sbjct: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135
Query: 561 EQQLDIMNKQYQQLESRLDEILS----------RIAKETEEI-----------KDLEEQL 599
E + + + K+ + L+S D ++ R A E E + K+LE +
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
Query: 600 TEGQIAANEALKK-----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL----- 649
+ + N+ LK+ DLE ++ QE + E +KL E + L
Sbjct: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS 1255
Query: 650 -LQRLTEV-----------------------------EQERDQLEIVAMDAENMRKELAE 679
L + TEV +++ QL+I + N + L++
Sbjct: 1256 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1315
Query: 680 LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
L+ L+E++ L Q Q + LE + +D + ++ ++K+ L + ++
Sbjct: 1316 LKGNLEEEN--RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1371
Score = 42.0 bits (97), Expect = 0.007
Identities = 89/402 (22%), Positives = 152/402 (37%), Gaps = 51/402 (12%)
Query: 1318 HHNLENEVSRLED-IMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
H NLE E LED Q LK K + E + K + EK + E + N + + E K L E
Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGE 1246
Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
+ L+ T + ++ E L T+ + KSL ++ + ++ L
Sbjct: 1247 NDRLNHTYSQLLKE-------TEVLQTDHKNLKSLLNNSKL-------------EQTRLE 1286
Query: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
L E +L T K N E + K +L EE R + L+ ++
Sbjct: 1287 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL-------EEENRHLLDQIQTLMLQNR 1339
Query: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
L ++KDL ++Q + + ++N+ L ++KEKL E++ K +
Sbjct: 1340 TLLEQNMESKDL--FHVEQRQYIDKLNE-----------LRRQKEKLEEKIMDQYKFYDP 1386
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKS-QVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
+ + LK +++ K E+ KS +T + + + QL H+ Q
Sbjct: 1387 SPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDS-----QD 1441
Query: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNV--QISERKTQLTLI 1673
S L++ LG T+ + N + + L + + L V IS K + L
Sbjct: 1442 SSSVGSNSLEDGQTLG-TKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELG 1500
Query: 1674 KQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
N V +L N D E+ QG+
Sbjct: 1501 AMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGV 1542
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 159 bits (403), Expect = 2e-38
Identities = 216/1045 (20%), Positives = 453/1045 (43%), Gaps = 138/1045 (13%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + + ++ + A KR+ E E EL +IDDL +E +E H T
Sbjct: 918 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE---KEKHATEN 974
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE-------KTLLKRRSELRE 1437
K + + + G E++ +K+L+ H+ +D+++ E KT K ++ +
Sbjct: 975 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVED 1034
Query: 1438 ADRLLAEAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
+ L E E +L E+ K +E A+ S+L E+D ++L+ R L K D
Sbjct: 1035 LESSL-EQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER-------LKKKDF 1086
Query: 1497 QLRSLQADAKDLE------QHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
+ LQ+ +D + Q KIK+ + ++E+ + + A+ + K++ EL++
Sbjct: 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE 1146
Query: 1550 LQKDIEMA--------ERNEDHHLQVLK----------ESEVLLQAKRAE----LEKLKS 1587
L + +E A E N+ + LK + E ++ A R + + +L
Sbjct: 1147 LSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE 1206
Query: 1588 QVTSQQQEMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIRE 1644
Q+ + Q+ L+++ K E+ L SM ++KA+L++ R E +++E E
Sbjct: 1207 QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE 1266
Query: 1645 VKSLLEELSFQK-------GELNVQISERKT---QLTLIKQEIEKEEENLQVVLRQMSKH 1694
++ L EL+ QK GEL+ Q+ E+++ QL+ KQ ++ E L+ L + +K
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Query: 1695 KTELKNILDMLQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQ 1745
K L + L Q H+ L+ Q++ QR ++VA K E + +Q+
Sbjct: 1327 KNALAHAL---QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1383
Query: 1746 ISQQQKGEIEWQKQL----------------LERDKR----EIERMTAESRALQSCVECL 1785
+ ++ + + ++L LE+ K+ E+E + + S L
Sbjct: 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Query: 1786 SKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
K++ + + W+ K +++ L A+ + S+ + L KL+ + +L+ + R+
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQE-------ELANVQDHLNLAKQDLLHTTKHQDVLL 1898
+L +I+ + +Q+ E + ++ L++ E A++Q L A+ L H +
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 1899 SEQTRLQKDIS-EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKER 1957
E T+++ +I + A + E+ ++ + Q+ ++ +Q+ ++ V+ RL+K+
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE----VRSRNEAIRLKKKM 1619
Query: 1958 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLE 2017
E + +++E + L Q + L +S Q+ L ++ +R ++
Sbjct: 1620 EGDLNEIE---IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED--------- 1667
Query: 2018 KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
K QL+ +VE+ L LQ E + +RA Q RK AE+++
Sbjct: 1668 -----LKEQLA-----IVERRANL--LQAEVEELRATL----EQTERARKLAEQELLDSN 1711
Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELK 2137
E +++ +Q + +K+ + + + + +E ++D + K + ELK
Sbjct: 1712 ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK 1771
Query: 2138 KQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLE 2197
K+ LER + + ++ L+ + + + +LK + + +L I E LE
Sbjct: 1772 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLET---RIRELEFELE 1828
Query: 2198 GELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMS 2257
GE + E++ ++L + R + L +KL+ + K Q
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEA-D 1887
Query: 2258 KQAEVLIKGKRQTEGTLHSLRRQVD 2282
+QA + R+ + L + D
Sbjct: 1888 EQANAHLTKFRKAQHELEEAEERAD 1912
Score = 159 bits (401), Expect = 4e-38
Identities = 214/1015 (21%), Positives = 447/1015 (44%), Gaps = 139/1015 (13%)
Query: 1425 EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
EK + + E ++ LA++E++ +EK V++ D + LQ ++++E L A
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ---LQVQAESENL-LDA 902
Query: 1485 QETAVNLVKADQQL----RSLQADAKDLEQ---------HKIKQE--EILKEINKI---V 1526
+E L+KA QL + + A+D E+ K++ E E+ K+I+ + +
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 1527 AAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESEVLLQAKRAEL 1582
A + + K + LTEEL L + I R ++ H Q L + LQA+ ++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDD----LQAEEDKV 1018
Query: 1583 EKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHI 1642
L + +Q++ L+ L +K+ L+ + + K L+ L+L + + + N
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKK----LRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 1643 REVKSLLEELSFQKGELNVQISERKT--------------QLTLIKQEIEKEEENLQVVL 1688
+++ L++ F+ +L ++ + +T ++ +++EIE E
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 1689 RQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSELEKTQVAVLEE 1736
+Q S + EL+ + + L Q+E E + LKL+ D + L+ +
Sbjct: 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194
Query: 1737 KLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKC 1796
K +++ ++ +Q ++ KQ LE++K E + E L S +E +SK K +L++ C
Sbjct: 1195 KKHADSVAELG-EQIDNLQRVKQKLEKEKSEFK---LEIDDLSSSMESVSKSKANLEKIC 1250
Query: 1797 DIWEKKLAQTK-------RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLH 1849
E +L++ + R L+ Q+ +L + + + + QL+R K +
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 1850 NDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDIS 1909
+++QL+E+ +A N+L L + + +L ++ + + L ++ +++
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
Query: 1910 EWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMMFQRLQKERES-- 1959
+W ++E Q+ EE ++ Q+LQ + ++E K E QRLQ E E
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLM 1430
Query: 1960 -EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE--------E 2010
+ + + L ++Q +K L + K+K ++ +++ A+ + R+L E E
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490
Query: 2011 RWCESLEKTLSQTK---RQLSEREQQLVEKS---GELLALQKEADSMRADFSLLRNQFLT 2064
+ LE + K +++++ +Q+ E EL +K+ + +AD L +
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550
Query: 2065 ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKE-MATIELV--AQDNHERAR- 2120
+ E ++ ++ L +S++++ + E+ +E +++ T+E + A D R+R
Sbjct: 1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN 1610
Query: 2121 ---RLMK----ELNQMQYEYTELKKQMAN--------QKDLERRQMEISDAMRTLKSEVK 2165
RL K +LN+++ + + +Q A Q L+ Q+ + DA+R + ++K
Sbjct: 1611 EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG-QEDLK 1669
Query: 2166 DEIRTSLKNLNQFLPELPADLEAILERNENLE--GELESLKEN----LPFTMNEGPFEEK 2219
+++ + N E+ +L A LE+ E E E L N L T N K
Sbjct: 1670 EQLAIVERRANLLQAEV-EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK 1728
Query: 2220 LNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAEV---LIKGKRQT 2270
+ +M E R+ E++ K A + + K+ + L + K+
Sbjct: 1729 KKL-ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787
Query: 2271 EGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQNQEKNASA 2324
E T+ L+ ++D +L A + +LE+ + E + +L Q+KN +
Sbjct: 1788 EQTVKDLQHRLDEAEQL-----ALKGGKKQIQKLETRIRELEFELEGEQKKNTES 1837
Score = 126 bits (316), Expect = 3e-28
Identities = 213/943 (22%), Positives = 407/943 (43%), Gaps = 129/943 (13%)
Query: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ-KQSCEELKSDL 328
EE ++ + +L K + +EL+ K ++E KN +L + E +L ++ C++L +
Sbjct: 855 EEFQKTKDELAKSEAKRKELEEKLVTLVQE-KNDLQLQVQAESENLLDAEERCDQL---I 910
Query: 329 NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
K +L + K E+T + + E+ EL K K E E +E+ K D+ +
Sbjct: 911 KAKFQL-EAKIKEVTERAEDEEEINAELTAKK--RKLE------DECSELKKDIDDLE-L 960
Query: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISA 448
++ ++ ATE+ + + + + + R H L+ +E K+++
Sbjct: 961 TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020
Query: 449 AQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLS------GRL 502
S+L ++E E + E+ K+L ++ K G DL Q S +
Sbjct: 1021 LNKTKSKLEQQVEDLESSL----EQEKKLRVDLERNKRKLEG-DLKLAQESILDLENDKQ 1075
Query: 503 QLVNKLRQEALDL-ELQMEKQKQEIAGKQ--KEIKDLQIAIDSLDSKDPKHSHMKAQKSG 559
QL +L+++ + +LQ + + ++ G Q K+IK+LQ I+ L+ + +A ++
Sbjct: 1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE---RATRAK 1132
Query: 560 KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVIS 619
E+Q ++ ++L RL+E + + E K E + + + EA + V +
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192
Query: 620 GLQEYLGTIKGQATQAQNECR-KLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELA 678
+++ ++ Q N R K + EKE +L E++ +E V+ N+ K
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-EIDDLSSSMESVSKSKANLEKICR 1251
Query: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK----VTRLTQ 734
LE L E N +Q++ +L+ ++ L+ EA +L +LE+ V++L++
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQT-------EAGELSRQLEEKESIVSQLSR 1304
Query: 735 LEQS------ALQAELEKERQALKNALGKA-------------QFSEEKE---------- 765
+Q+ L+ +LE+E +A KNAL A Q+ EE+E
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKA-KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Query: 766 QENSELHAKLKHLQDDNNLLKQQLKDFQNHL-NHVVDGLVRPEEVAARVDELRRKLKLGT 824
+ NSE+ + D ++L++ + L + D + E V A+ L + +
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 825 GE----MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR-ERKLQEEMALQQE-- 877
GE M ++ L +L Q+ F ++LA K + +E+Q E L+E +L E
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 1483
Query: 878 KLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN--EIHYLQENLKSMEEIQGLTDL 935
KL EE E N ++ + Q EN IH L+++ K +E + L
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Query: 936 QLQEAD----EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKK----AVATSD 987
L+EA+ E+ +IL EL + K D K E+ D+E+++LK+ V T
Sbjct: 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK----DEEIEQLKRNYQRTVETMQ 1599
Query: 988 KLATAELTIAKDQL---KSLHGTVMKI-------NQERAE----------ELQEAERFSR 1027
AE+ + + K + G + +I N++ AE +L++ +
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659
Query: 1028 KAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTG----------VGTGANSQVLEI 1077
A + DL A +E NLL+ + E+ R +E+T + + Q+L
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHT 1719
Query: 1078 E--KLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAE 1118
+ L T ++ T++ +LQ+ ++ D + E + I +
Sbjct: 1720 QNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 1762
Score = 119 bits (298), Expect = 3e-26
Identities = 163/756 (21%), Positives = 342/756 (45%), Gaps = 85/756 (11%)
Query: 440 EDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA-----IQLKKISEAGKDL- 493
E +EK ++ Q + ++L +++ + +L A E QL +A ++K+++E +D
Sbjct: 873 ELEEKLVTLVQEK-NDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEE 931
Query: 494 -LYKQLSGRLQLV----NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS--- 545
+ +L+ + + + ++L+++ DLEL + K ++E + ++K+L + LD
Sbjct: 932 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA 991
Query: 546 ------KDPKHSHMKA--QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLE- 596
K + +H +A +E +++ +NK +LE +++++ S + +E + DLE
Sbjct: 992 KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051
Query: 597 -EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE 655
++ EG + + DLE L E L + Q Q+ K+ DE+ LQ +
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS---KVEDEQTLGLQFQKK 1108
Query: 656 VEQERDQLEIVAMDAENMRKELAELESA----LQEQHEVNASLQQTQGDLSAYEAELEAR 711
+++ + ++E + + E R A+ E +E E++ L++ G +++ + EL +
Sbjct: 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA-GGVTSTQIELNKK 1167
Query: 712 LNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKA-----QFSEEKEQ 766
R+AE +L+ +LE+ T L+ A+ A L K+ LG+ + ++ E+
Sbjct: 1168 ---REAEFLKLRRDLEEAT----LQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 767 ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKL-KLGTG 825
E SE ++ L + + + + + D L E + +E++R L +L T
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL---SEARGKNEEIQRSLSELTTQ 1277
Query: 826 EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEM--------ALQQE 877
+ + + + L + L + + S++ + + + +R+L+EE ALQ
Sbjct: 1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS 1337
Query: 878 KLATG--QEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDL 935
+ +E++ + E E + K E + + E +Q + +EE +
Sbjct: 1338 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQ 1396
Query: 936 QLQEADEEKERILAQLRELEKKKK-----LEDA-----KSQEQVFGLDKELKKLKKAVA- 984
+LQ+++E+ E + A+ LEK K+ +ED ++ LDK+ + K +A
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456
Query: 985 --TSDKLATAELTIAKDQLKSLHGTVMKIN---QERAEELQEAERFSRKAAQAARDLTRA 1039
T + + AEL + + +SL + K+ +E ++L+ +R ++ Q DLT
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 1516
Query: 1040 EAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
AE + L + +Q +E+EK + L +E+ +E + +I R+Q L
Sbjct: 1517 IAENGKTIHELEKSRKQ--IELEKADIQ-------LALEEAEAALEHEEAKILRIQLELT 1567
Query: 1100 LTGSDNKGGFENVLEEIAELRREVSYQNDYISSMAD 1135
S+ EEI +L+R + + S D
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Score = 119 bits (298), Expect = 3e-26
Identities = 230/1089 (21%), Positives = 449/1089 (41%), Gaps = 204/1089 (18%)
Query: 125 VKLEVLNLSYNLIGKIEKLDKLLKLR----------------ELNLSYNKISKIEGIENM 168
++L+V S NL+ E+ D+L+K + E ++ +K +E+
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 169 CNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVEN 228
C+ K +I+ + + L K K NK+ +L + +L L + I+ + E
Sbjct: 948 CSELK-----KDIDDLELTLAKVEKEKHATE---NKVKNLTE--ELSGLDETIAKLTREK 997
Query: 229 PVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEE 288
+ H ++L+ L+ + +D+ + + + ++E+ DLE + + ++
Sbjct: 998 KALQEAHQ--------QALDDLQAE----EDKVNSLNK-TKSKLEQQVEDLESSLEQEKK 1044
Query: 289 LKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQK 348
L+ R N+ KL LK L ++S +L++D +E LK+K E CQ
Sbjct: 1045 LRVDLER------NKRKLEGDLK----LAQESILDLENDKQQLDERLKKKDFEY---CQL 1091
Query: 349 QYELEQE----LAFYK----IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFAT 400
Q ++E E L F K + A+ E L E E ++A +S Y R +
Sbjct: 1092 QSKVEDEQTLGLQFQKKIKELQARIEELE----EEIEAERATRAKTEKQRSDYARELEEL 1147
Query: 401 ESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDK-----EKKISAAQTRLSE 455
S ++ A V ++E +++ + + LR T + KK + + L E
Sbjct: 1148 -SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE 1206
Query: 456 LHDEIEKAEQQILRATEEFK--------QLEEAIQLK------------KISEA-GK-DL 493
D +++ +Q++ + EFK +E + K ++SEA GK +
Sbjct: 1207 QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE 1266
Query: 494 LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIA----GKQKEIKDLQIAIDSLDSKDPK 549
+ + LS ++L+ EA +L Q+E+++ ++ KQ + + L+ ++
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Query: 550 HSHMKAQKSGKEQQLDIMNKQYQQ-------LESRLDEILSRIAK-----------ETEE 591
+ + D++ +QY++ L+ L + S +A+ TEE
Sbjct: 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1386
Query: 592 IKDLEEQLTE-------------GQIAANEALKKDLEGVISGLQ---------------- 622
+++ +++L + + A+ E K+ L+G + L
Sbjct: 1387 LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK 1446
Query: 623 -----EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEV----EQERDQLEIVAMDAENM 673
+ L K + ++Q E E +L L ++ E+ DQLE V + +N+
Sbjct: 1447 QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL 1506
Query: 674 RKELAELESALQEQ----HEVNASLQQTQ---GDLSAYEAELEARLNLRDA-------EA 719
+E+A+L + E HE+ S +Q + D+ E EA L +A E
Sbjct: 1507 EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 720 NQLKEEL-----EKVTRLTQLE----------QSALQAELEKERQALKNALGKAQFSEEK 764
Q+K E+ EK + QL+ QSAL AE+ +A++ L K +
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR--LKKKMEGDLN 1624
Query: 765 EQENSELHAK------LKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRR 818
E E HA LKHL+ ++ QLKD Q HL+ + G +E A V+
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRS----VQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 819 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR-ERKLQEEMALQQE 877
L+ E+ + LA+ + S + ++ + + ++KL+ ++ Q
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Query: 878 KLATGQEEFRQACERALEARMNFDKRQHEARIQQ-----MENEIHYLQENLKSME-EIQG 931
++ + R A E+A +A + E + +Q +E L++ +K ++ +
Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1800
Query: 932 LTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 991
L L+ ++ +++ ++RELE + + E K+ E V GL K +++K+ S++
Sbjct: 1801 AEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRK 1860
Query: 992 AELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQ---N 1048
L + +D + L V ++ E ++A K +A +L AE ++ + N
Sbjct: 1861 NVLRL-QDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVN 1919
Query: 1049 LLRQKGEQF 1057
LR K F
Sbjct: 1920 KLRAKTRDF 1928
Score = 108 bits (269), Expect = 8e-23
Identities = 130/608 (21%), Positives = 261/608 (42%), Gaps = 63/608 (10%)
Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
C++ E + + E +Q SK E +W + + + EEL L Q
Sbjct: 1341 CDLLREQYEEEQEGKAE--LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398
Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
+ E +VE ++ ++ K + G VE LM ++E ++K ++ + ++ E
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK 1458
Query: 1421 IEC------IEKTLLKRRS---ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
+C +E +L + RS EL + EA +L K + KN ++ D +
Sbjct: 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIA 1518
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAK-DLEQHKIKQ-----EEILKEINKI 1525
+ ELE+ ++ + L KAD QL +A+A + E+ KI + ++ EI++
Sbjct: 1519 ENGKTIHELEKSRKQ--IELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRK 1576
Query: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1585
+A KD + + L + ++ E +Q D E+ RNE L+ +K+
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQSAL-DAEVRSRNEAIRLK----------------KKM 1619
Query: 1586 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV 1645
+ + + +++ +RQ + L +QG + + L +ALR G+ ++ E+ +
Sbjct: 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR-GQEDLKEQLAIVERR 1678
Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ-MSKHKTELKNILDM 1704
+LL+ + EL + + + L +QE+ E +Q++ Q S T+ K D+
Sbjct: 1679 ANLLQA---EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDL 1735
Query: 1705 LQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERD 1764
+QL++ + D R +E EK + A+ + + E L++ Q +E K+ LE+
Sbjct: 1736 MQLQSEVEDASR---DARNAE-EKAKKAITDAAMMAEELKK-EQDTSAHLERMKKNLEQT 1790
Query: 1765 KREIERMTAESRAL-----QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819
++++ E+ L + ++ L +L+ + + +KK ++ + L E K
Sbjct: 1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE 1850
Query: 1820 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1879
E+ NV +LQ +D+L S +Q Q EL ++
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Query: 1880 LNLAKQDL 1887
++A+ +
Sbjct: 1911 ADIAESQV 1918
Score = 102 bits (253), Expect = 6e-21
Identities = 123/617 (19%), Positives = 260/617 (42%), Gaps = 57/617 (9%)
Query: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ------------- 1793
S + + E+ K+ ++ K E+ + A+ + L+ + L +EK DLQ
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 1794 -EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
E+CD K Q + + E ++ E+ +L RKL+ E +L +D L +
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 1853 SAMQQQLQEKREAVNSLQEELANVQDHL-NLAKQDLLHTTKHQDVLLSEQTRLQK--DIS 1909
+ ++++ V +L EEL+ + + + L ++ HQ L Q K ++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 1910 EWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKV 1969
+ ++ E ++ E+ +Q + L+ ++E NK KL + Q + E+++ +L+
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Query: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSE 2029
+ QL+ ++ D+++ Q K+ + R+ L+EE E+ T ++T++Q S+
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE---IEAERATRAKTEKQRSD 1139
Query: 2030 REQQL------VEKSGELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQVASLKEALKI 2082
++L +E++G + + Q E + R A+F LR + E VA+L++
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 2083 QRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMA- 2141
++L + + ++ ++KE + +L D + K ++ L+ Q++
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259
Query: 2142 ---NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG 2198
++++R E++ L++E E+ L+ + +L +A ++ E L+
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQTEA-GELSRQLEEKESIVSQLSRSKQAFTQQTEELKR 1318
Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
+LE E K + H + L + E KA+L+ +SK
Sbjct: 1319 QLEE--------------ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 2259 -QAEV----------LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESS 2307
+EV I+ + E L +++ E V + +A AS Q
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Query: 2308 LTEDSQLGQNQEKNASA 2324
ED + + + +A
Sbjct: 1425 EVEDLMVDVERANSLAA 1441
Score = 89.4 bits (220), Expect = 4e-17
Identities = 130/683 (19%), Positives = 286/683 (41%), Gaps = 80/683 (11%)
Query: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRV 1723
+E + ++ +K+E +K ++ L + +K K EL+ L L E ++LQ + +
Sbjct: 844 AETEKEMATMKEEFQKTKDELA---KSEAKRK-ELEEKLVTLVQEKNDLQLQVQAESENL 899
Query: 1724 SELEKTQVAVLEEKLELE-NLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV 1782
+ E+ +++ K +LE +++++++ + E E + AE
Sbjct: 900 LDAEERCDQLIKAKFQLEAKIKEVTERAEDE---------------EEINAE-------- 936
Query: 1783 ECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN 1842
L+ +K L+++C +K + + LA E+ ++ ++ L + L + + +L
Sbjct: 937 --LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT 994
Query: 1843 RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT 1902
R+K +L LQ + + VNSL + + ++ + + L K + L +
Sbjct: 995 REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKR 1054
Query: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQ-------VLQNEIEENKLKLVQQEMMFQRLQK 1955
+L+ D+ D + +++ ++L+ LQ+++E+ + +Q + + LQ
Sbjct: 1055 KLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114
Query: 1956 ERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCES 2015
E E ++E + T + + EK+ +D +L++ LS+ L V + Q E +
Sbjct: 1115 RIEELEEEIEAERAT----RAKTEKQRSDYARELEE-LSERLEEAGGVTSTQIELN--KK 1167
Query: 2016 LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVAS 2075
E + +R L E+ ++ + AL+K+ A+ + ++K EK+
Sbjct: 1168 REAEFLKLRRDL---EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE--- 1221
Query: 2076 LKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE---LVAQDNHERARRLMKEL----NQ 2128
K K++ L ++ + + ++K T+E A+ +E +R + EL ++
Sbjct: 1222 -KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 2129 MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPA---D 2185
+Q E EL +Q+ ++ + + A E+K ++ K N L + D
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD 1340
Query: 2186 LEAILER-NENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDE-HWRGEALREKLRH 2243
+ + E+ E EG+ E + + K + +E + L ++L+
Sbjct: 1341 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1400
Query: 2244 REDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSAS------ 2297
E++++A C S L K K++ +G + L V+ L + +
Sbjct: 1401 SEEQVEAVNAKCAS-----LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Query: 2298 ------SPSLSQLESSLTEDSQL 2314
S ++LE+SL E L
Sbjct: 1456 EWKTKCEESQAELEASLKESRSL 1478
Score = 82.8 bits (203), Expect = 4e-15
Identities = 111/543 (20%), Positives = 221/543 (40%), Gaps = 102/543 (18%)
Query: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
K A+T++ +A +E + + L K E ++L+++L L ++K ND+ QLQ
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEK----NDL-----QLQV 892
Query: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
+ E+ N L E + D L+ + +L+ I E R ED ++
Sbjct: 893 QAESENLLDAE-------------------ERCDQLIKAKFQLEAKIKEVTERAEDEEEI 933
Query: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
+ + L++E E K + E+ +++KE+ + E+K+ K
Sbjct: 934 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---------------KN 978
Query: 1982 LTDQKSKLDQVLSKVL--------AAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQ 2033
LT++ S LD+ ++K+ A ++ + LQ EE SL KT S+ ++Q+ + E
Sbjct: 979 LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038
Query: 2034 LVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLE 2093
L ++ + L++ + D L + L L+ + QL++ L +
Sbjct: 1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILD---------------LENDKQQLDERLKK 1083
Query: 2094 QKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEI 2153
+ E +Q ++ +D + K++ ++Q EL++ ++E
Sbjct: 1084 KDFEYCQLQSKV-------EDEQTLGLQFQKKIKELQARIEELEE-----------EIEA 1125
Query: 2154 SDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNE 2213
A R + + + L+ L++ L E +E N+ E E L+ +L +
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ 1185
Query: 2214 -----GPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKR 2268
+K S + ++ + +++KL + K ++ +S E + K K
Sbjct: 1186 HEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD-LSSSMESVSKSKA 1244
Query: 2269 QTEGTLHSLRRQVD-----------ALGELVTSTSADSASSPSLS-QLESSLTEDSQLGQ 2316
E +L Q+ +L EL T S + LS QLE + SQL +
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 1304
Query: 2317 NQE 2319
+++
Sbjct: 1305 SKQ 1307
Score = 37.0 bits (84), Expect = 0.23
Identities = 39/162 (24%), Positives = 79/162 (48%), Gaps = 15/162 (9%)
Query: 1320 NLENEVSRLEDIMQH-----LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE 1374
NLE V L+ + LK K++ + + R+ E E+E + ++ + E
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845
Query: 1375 CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE-KSLKHHEDIVDEIECIEKTLLKR-R 1432
V+EL T Q + +K+ + ++ L+ +L+++ KS K + DE T ++ +
Sbjct: 1846 RRVKEL--TYQSEEDRKNVL--RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQ 1901
Query: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTE 1474
EL EA+ AES+++ + KT++ FT ++ + ++E
Sbjct: 1902 HELEEAEERADIAESQVNKLRAKTRD----FTSSRMVVHESE 1939
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 159 bits (402), Expect = 3e-38
Identities = 221/1097 (20%), Positives = 468/1097 (42%), Gaps = 161/1097 (14%)
Query: 1321 LENEVSRL----EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
LE +++ L +D + LK+ E + E+ + EL ++ +Q LE +
Sbjct: 585 LEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQK 644
Query: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
V EL +++ ++KD D +E LM ++ K L + + L
Sbjct: 645 VNELTGGLEETLKEKDQNDQKLEKLMVQM--------------------KVLSEDKEVLS 684
Query: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
+ L E ++LS K++ +E F K ++ E +LE++ Q L+ +Q
Sbjct: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEH-ITQLEKKLQ-----LMVEEQ 738
Query: 1497 QLRSLQADAKDLEQHKIKQE--EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD- 1553
+ + + +++ +K + LKE+ V+ +DS+ + + + + E L K+ ++
Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVS-EDSEEKDVVNVLQAVGESLAKINEEK 797
Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
+A + ++ L++ KE + L + + E+LKS + +QE +L ++L + E L
Sbjct: 798 CNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEAL 857
Query: 1614 QGSMVQAKADLQEALRLGET-------EVTEKCN----HIREVKSLLEELSFQKGELNV- 1661
Q +++ K + E RL EV++ C+ H + K ++E K L
Sbjct: 858 QSDLLEMK-NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK 916
Query: 1662 QISERKTQLTLIK-----------------QEIEKEEENLQVVLRQMS-----------K 1693
++ +R+ +L L+K +E+E++ ENL+ ++ K
Sbjct: 917 ELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVK 976
Query: 1694 HKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGE 1753
K EL + Q EL+ L+ + DQ L + +++ +NL ++Q +
Sbjct: 977 AKKELDSSRKETQTVKEELESLRSEKDQ----LSASMRDLIQGAESYKNLLLEYEKQSEQ 1032
Query: 1754 IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL-------QEKCDIWEKKLAQT 1806
++ +K+ + IE +T + R E ++ + EDL Q + E ++ +
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092
Query: 1807 KRVLAAAEENSKMEQ--------------SNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
+R A ++ + E+ + LE+L++ ++K +++L + ++ + D
Sbjct: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152
Query: 1853 ---SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDIS 1909
+ M ++ + + L ++L N + + +Q++ + Q+ L E T LQ +
Sbjct: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212
Query: 1910 EWANRFEDCQKEEETKQQQLQV-LQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
++ +E+ TK +QL V + E+ ++K ++ L+ E E+ + ++E K
Sbjct: 1213 QY--------EEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYK 1264
Query: 1969 VTLKE---QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKR 2025
+ L E ++H++ + L + + LS A ++RV LQEE R ++ + T++
Sbjct: 1265 IQLAEITSEKHKIHEHLKTSAEQHQRTLS---AYQQRVTALQEECRAAKAEQATVTSEFE 1321
Query: 2026 QLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRS 2085
R ++++ Q E + + ER+ E + LK L+ ++
Sbjct: 1322 SYKVRVHNVLKQQKNKSMSQAETEGAK-----------QEREHLEMLIDQLKIKLQDSQN 1370
Query: 2086 QLEKNLLE----QKQENSCIQKEMATIELVAQDNHERARRL---MKELNQMQYEYTELKK 2138
L+ N+ E Q + ++ +++ ++ E +L E M+ E+T+
Sbjct: 1371 NLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVS 1430
Query: 2139 QMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPEL-----PADLEAILERN 2193
Q+ +Q ++ R D +R L+ E + + T + L++ +L + +
Sbjct: 1431 QLTSQNEVLRNSFR--DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ 1488
Query: 2194 ENLEGELESLKENLPF------TMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDR 2247
++L+ E +LP T EG E + V + ++L + L E +
Sbjct: 1489 QSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTY--TQSLEQLLNSPETK 1546
Query: 2248 LKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESS 2307
L+ L H + E++ K L S + D L L+ T A +A + Q++
Sbjct: 1547 LEPPLWHAEFTKEELVQK--------LSSTTKSADHLNGLLRETEATNAI--LMEQIKLL 1596
Query: 2308 LTEDSQLGQNQEKNASA 2324
+E +L +NQE+ SA
Sbjct: 1597 KSEIRRLERNQEREKSA 1613
Score = 153 bits (386), Expect = 2e-36
Identities = 235/1093 (21%), Positives = 487/1093 (44%), Gaps = 136/1093 (12%)
Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLE----CEVE 1378
E+ L++ ++L+ +K+E S R+ + ++ EL + + QE +S++ +V
Sbjct: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 517
Query: 1379 ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS----E 1434
EL + ++ +KD + V L E E L +++V E+E K L ++
Sbjct: 518 ELQQKLRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIKNLQEKNGVYLLS 574
Query: 1435 LREADRLLAEAESELSCTKE-------KTKNAVEKFTDAKRSLLQTESDAEELERRAQET 1487
L + D +L E E +++ E K KN+ E+ + + + E EL ++ ++T
Sbjct: 575 LSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQT 634
Query: 1488 AVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL 1547
+ +Q++ L ++ + K + ++ L+++ + D + LS + + L EE
Sbjct: 635 IQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN 694
Query: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELE-KLKSQVTSQQQEMAVLDRQLGHK 1606
KL E + + D + + ++ +V+L+ +LE KL+ V Q +L+ + K
Sbjct: 695 NKLSS--EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQK 752
Query: 1607 ---KEELHLL---QGSMVQAKADLQEALR----LGETEV---TEKCN----HIREVKSLL 1649
K +L+ GS V ++ ++ + +GE+ EKCN +V L
Sbjct: 753 LFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELE 812
Query: 1650 EELSFQKGELNVQISERKTQLTLIKQE---IEKEEENLQVVLRQMSKHKTELKNILDMLQ 1706
+E+ + E VQ E K+ L +QE + KE E +Q + E+KN + +
Sbjct: 813 KEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTR 872
Query: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKL---ELENLQQISQQQKGEIEWQKQLLER 1763
LEN Q L +Q ++ K+++ +EK E ENL+ + +Q+ E+ ++ L
Sbjct: 873 LEN---QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK--ELRDRRAELIL 927
Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
K + + + S V+ L ++ E+L+++C E+K+ + K V A++ +
Sbjct: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
Query: 1824 LEKLELNVRKLQQELDQLN---RDKL-------SLHNDISAMQQQLQEKREAVNSLQEEL 1873
+ ++ + L+ E DQL+ RD + +L + +QL ++E N+ + +
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 1874 ANVQ----------DHLNLAKQDLL---HTTKHQDVLLSEQ---TRLQKDISEWANRFED 1917
++ + +N +DLL T + LL Q + K + + E
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEK 1107
Query: 1918 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE-----RESEESKLETSKVTLK 1972
QKE++ K+ V NE+EE +++L +++ Q+ +E ++++++ L ++
Sbjct: 1108 LQKEQKIKEHATTV--NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADY 1165
Query: 1973 EQ-QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSERE 2031
E+ +L ++LT++ +K++ + ++ +++ TLQEE SL+ ++ Q + + ++ +
Sbjct: 1166 ERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEE---ITSLQSSVQQYEEKNTKIK 1222
Query: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK-------------- 2077
Q LV+ E LA K+A++ D +L+ E + +++QV K
Sbjct: 1223 QLLVKTKKE-LADSKQAET---DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIH 1278
Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQK-------EMATIELVAQDNHERARRLMKELNQMQ 2130
E LK Q ++ L +Q + +Q+ E AT+ + R ++K+
Sbjct: 1279 EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKS 1338
Query: 2131 YEYTELKKQMANQKDLE----RRQMEISDAMRTLKSEVKD------EIRTSLKNLNQFLP 2180
E + ++ LE + ++++ D+ L+ V + E T L+ N+ L
Sbjct: 1339 MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ 1398
Query: 2181 ELPADLEAILER-----NENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRG- 2234
E + + E+ +EN+ + E + T H+ +EH +
Sbjct: 1399 ETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV 1458
Query: 2235 EALREKLRHREDRLKAQLRH-------CMSKQAEVLIKGKRQTEGTLHSLRRQVDALGEL 2287
E L+++L E +L QL++ S+Q+ ++ +R T+ L + GE
Sbjct: 1459 ETLQQQLSKMEAQL-FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEG 1517
Query: 2288 VTSTSADSASSPS 2300
+ +T +S SS S
Sbjct: 1518 METTDTESVSSAS 1530
Score = 135 bits (341), Expect = 4e-31
Identities = 234/1049 (22%), Positives = 461/1049 (43%), Gaps = 164/1049 (15%)
Query: 1329 EDIMQHLKSKKREERWMRASKRQSEKEMEELH----------------HNIDDLLQEKKS 1372
ED+++ K + + ++ + EKE+EEL +D LL EK
Sbjct: 28 EDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAE 87
Query: 1373 LECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
E + L + K +Q+ VE +T++ E+E+S H + V EIE ++
Sbjct: 88 TEQQCLSLKKENIKMKQE-------VEDSVTKMGDAHKELEQS---HINYVKEIENLKNE 137
Query: 1428 LLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET 1487
L+ RS+ +E ++ L E+ N + ++ + +E + ++L+ ++
Sbjct: 138 LMAVRSKY-------SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI 190
Query: 1488 AVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL 1547
++Q+ LQ K L+ +++E + ++ I+ A +Q K L EEL
Sbjct: 191 RPGF---EEQILYLQ---KQLDATTDEKKETVTQLQNIIEANSQHYQ---KNINSLQEEL 241
Query: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607
+L K I E E ++ + E + AE+ KL + ++ ++ + K
Sbjct: 242 LQL-KAIHQEEVKE-----LMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKY 295
Query: 1608 E-ELHLLQGSMVQAKADLQ------EALRLGETEVTEKCNHIRE-VKSLLEELSFQKGEL 1659
E EL L+ + A D Q + E V EK H+ + +K L + S K E+
Sbjct: 296 ECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEV 355
Query: 1660 NVQISERKTQLTL----IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE------- 1708
++ K +L + IK E E E+L+ + ++ K E +++ L+ E
Sbjct: 356 TY-MNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414
Query: 1709 --------NHELQGLKLQHDQRVSELEKTQVAVLE-EKLEL-----------ENLQQISQ 1748
N E+Q LK QH + +SEL +T ++ E EKL L ENLQQ Q
Sbjct: 415 FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQ 474
Query: 1749 QQKGEIEWQKQLLERDKREIERMTAE-SRALQSCVECLSKEKEDLQEKC-DIWEKKLAQT 1806
+ E ++++E + E+ + S+ +S + + + +LQ+K + +K A
Sbjct: 475 EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALL 534
Query: 1807 KRVLAAAEENSKM--EQSNLEKLELNVRKLQQE-----LDQLNRDKL--SLHNDISAMQQ 1857
+ V EN K+ +Q + +LE ++ LQ++ L RD + L I+++ +
Sbjct: 535 ETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTE 594
Query: 1858 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1917
+ + + + EE+ N ++ +L K + + + L++ ++E E+
Sbjct: 595 EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEE 654
Query: 1918 CQKEEETKQQQLQVL---------QNEIEENKLKLVQQE---MMFQRLQKERESEESKLE 1965
KE++ Q+L+ L E+ ++K + +E + ++ Q R+ E +
Sbjct: 655 TLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ 714
Query: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKR 2025
V LKE QLEK+L + D L+K+L E+V+ L + + L++ S+
Sbjct: 715 KEDVILKEHITQLEKKLQLMVEEQDN-LNKLL-ENEQVQKLFVKTQLYGFLKEMGSEVSE 772
Query: 2026 QLSERE-QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR 2084
E++ +++ GE LA + + + + + R++ + E EK++ L+E +Q
Sbjct: 773 DSEEKDVVNVLQAVGESLA---KINEEKCNLAFQRDEKVLE---LEKEIKCLQEESVVQC 826
Query: 2085 SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQK 2144
+L+ L + +QE ++KE+ I+ E +Q + E+K AN+K
Sbjct: 827 EELKSLLRDYEQEKVLLRKELEEIQ--------------SEKEALQSDLLEMKN--ANEK 870
Query: 2145 DLERRQ---MEISDAMRTL-KSEVKDEIRTSLKNLNQFLPELPADLEAILERNE--NLEG 2198
Q +++ + +T KSE+ +E F+ E +L+ +LE+ E +
Sbjct: 871 TRLENQNLLIQVEEVSQTCSKSEIHNEKEKC------FIKE-HENLKPLLEQKELRDRRA 923
Query: 2199 ELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK 2258
EL LK++L + P + S V ++E + E L ++ + +E+++ +++ K
Sbjct: 924 ELILLKDSLA----KSPSVKNDPLSSVKELEE--KIENLEKECKEKEEKIN-KIKLVAVK 976
Query: 2259 QAEVLIKGKRQTEGT---LHSLRRQVDAL 2284
+ L +++T+ L SLR + D L
Sbjct: 977 AKKELDSSRKETQTVKEELESLRSEKDQL 1005
Score = 107 bits (268), Expect = 1e-22
Identities = 152/707 (21%), Positives = 297/707 (42%), Gaps = 93/707 (13%)
Query: 1320 NLENEVSRLEDIMQHLK-----------SKKREERWMRASKRQSEKEMEELHHNIDDLLQ 1368
NLE E E+ + +K S ++E + ++ E ++L ++ DL+Q
Sbjct: 955 NLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014
Query: 1369 ---EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDE 1420
K+L E E+ + +++ + + +E L +L + E +ED++
Sbjct: 1015 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLAR 1074
Query: 1421 IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEEL 1480
IE ++ ++ E R A + EL K + + +++ T ++ EEL
Sbjct: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHAT-------TVNELEEL 1127
Query: 1481 ERRAQETAVNLVKADQQLRSLQADAKD---LEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
+ + Q+ L K Q+L ++ DA+ + E ++KE+N+ + K++ + L
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
Query: 1538 K-------KKEKLTEELQKLQKDIEMAERNEDHHLQVL-KESEVLLQAKRAELE------ 1583
+ K+E L EE+ LQ ++ E Q+L K + L +K+AE +
Sbjct: 1188 QEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247
Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT---EKCN 1640
LK ++ + QQ++ V QL E H + + + Q L + VT E+C
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307
Query: 1641 HIR-EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIE---KEEENLQVVLRQMSKHKT 1696
+ E ++ E K ++ + ++K + ++ + E E +E E+L++++ Q+ K
Sbjct: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNK-SMSQAETEGAKQEREHLEMLIDQL---KI 1363
Query: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSELEK------TQVAVLEEKL---ELENLQQIS 1747
+L++ + LQ+ ELQ L+ +HD + K ++ A L EKL + EN+ S
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
Query: 1748 Q--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQ 1805
+ Q ++ Q ++L R+ R E K E LQ++ E +L Q
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHR---------KTVETLQQQLSKMEAQLFQ 1474
Query: 1806 TKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK-RE 1864
K E ++ S+ + L+ N+R E + L +H + ++ E
Sbjct: 1475 LKN-----EPTTRSPVSSQQSLK-NLR----ERRNTDLPLLDMHTVTREEGEGMETTDTE 1524
Query: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
+V+S +++ LN + L H + E + ++ A+ +E E
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEA 1584
Query: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 1971
N I ++KL++ E+ +ERE + LE K L
Sbjct: 1585 T--------NAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL 1623
Score = 103 bits (258), Expect = 2e-21
Identities = 203/1004 (20%), Positives = 426/1004 (42%), Gaps = 131/1004 (13%)
Query: 83 ITEALIKKLTKQDNLA------LIKSLNLSLSKDGGKKFK-YIENLEKCVKLEVLNLSYN 135
+ A +K L +++N L + L + LS+ K +I LEK ++L
Sbjct: 682 VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL-------- 733
Query: 136 LIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSL 195
++ + + L+KLL+ ++ + K ++ M + + ++ ++ +G+ L +
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793
Query: 196 RV--LNLKGNKISSLQDISK-LKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEG 252
NL + + ++ K +K LQ+ S++ E L Y Q + + LE ++
Sbjct: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEE-SVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852
Query: 253 QPVTTQ----DRQEAFERFSLE------EVERLERDLEKKMIETEELKS--KQTRFLEEI 300
+ Q + + A E+ LE +VE + + K I E+ K K+ L+ +
Sbjct: 853 EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPL 912
Query: 301 KNQDKLNKSLKEEAMLQKQSCEE---LKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
Q +L + + E +L K S + +K+D + + L++K L + C+++ E ++
Sbjct: 913 LEQKEL-RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971
Query: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKME 417
+ AK E S E +E + K + A+ +I A++ + +E
Sbjct: 972 LVAVKAKKE----LDSSRKETQTVKEELESLRSE--KDQLSASMRDLIQGAESYKNLLLE 1025
Query: 418 PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
++Q + + ++ED +++ + + ++ + E +I K L
Sbjct: 1026 YEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL 1085
Query: 478 EEAIQLKKISEAGKDLLYKQLSG-RLQLVNKLRQEAL------DLELQMEKQKQEIAGKQ 530
E +Q+ ++ A K ++ K+L +LQ K+++ A +L++Q++K+K+++ Q
Sbjct: 1086 E--VQILEVQRA-KAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL---Q 1139
Query: 531 KEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
K +++L++ KD QQ +MN + E + E+ ++ +
Sbjct: 1140 KTMQELELV-----KKDA-------------QQTTLMNMEIADYERLMKELNQKLTNKNN 1181
Query: 591 EIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLL 650
+I+DLE+++ + Q E L++++ + S +Q+Y ++L D K+
Sbjct: 1182 KIEDLEQEI-KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240
Query: 651 QRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE-VNASLQQTQGDLSAYEAELE 709
L + +LE E + +LAE+ S + HE + S +Q Q LSAY+ +
Sbjct: 1241 DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT 1300
Query: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENS 769
A L++ R + EQ+ + +E E + + N L + + + E
Sbjct: 1301 A---------------LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETE 1345
Query: 770 ELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL---------------VRPEEVAARVD 814
+ +HL+ + LK +L+D QN+L V L +E ++
Sbjct: 1346 GAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
Query: 815 ELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEE--- 871
ELR KL +I S + ++ ++ + S++ ++++ R+ + + R LQEE
Sbjct: 1406 ELREKL------CSIQSENMMM---KSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456
Query: 872 --MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEI 929
LQQ+ + F+ E + ++ + R ++ ++ L + + EE
Sbjct: 1457 TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLR-ERRNTDLPLLDMHTVTREEG 1515
Query: 930 QGL--TDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
+G+ TD + + + L QL + KLE + F ++ ++KL ++D
Sbjct: 1516 EGMETTDTESVSSASTYTQSLEQLLN-SPETKLEPPLWHAE-FTKEELVQKLSSTTKSAD 1573
Query: 988 KL------ATAELTIAKDQLKSLHGTVMKI--NQERAEELQEAE 1023
L A I +Q+K L + ++ NQER + E
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLE 1617
Score = 98.6 bits (244), Expect = 6e-20
Identities = 162/734 (22%), Positives = 314/734 (42%), Gaps = 107/734 (14%)
Query: 431 GHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAG 490
G + L+T ++ K + Q L I+KA+ R TE K++EE ++ K ++E
Sbjct: 18 GKSKLETLPKEDLIKFAKKQMML------IQKAKS---RCTELEKEIEE-LRSKPVTEGT 67
Query: 491 KDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
D++ K L+ RL +AL LE + E ++Q ++ K++ IK Q DS+ H
Sbjct: 68 GDII-KALTERL--------DALLLE-KAETEQQCLSLKKENIKMKQEVEDSVTKMGDAH 117
Query: 551 SHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEA- 609
++ ++++ + + + S+ E + + K+ EE + + +L+E N +
Sbjct: 118 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSE 177
Query: 610 -----LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
L++++E + G +E + ++ Q +E + E T LQ + E + Q
Sbjct: 178 DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDE----KKETVTQLQNIIEANSQHYQKN 233
Query: 665 IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE 724
I ++++EL +L++ QE+ + ++EA +AE N+L E
Sbjct: 234 I-----NSLQEELLQLKAIHQEE-------------VKELMCQIEASAKEHEAEINKLNE 275
Query: 725 ELEKVTRLTQLEQSALQ----AELEKERQALKNALGKAQFSEEKEQENS----ELHAKLK 776
E + + + + +Q ELE R+A NA Q QEN+ ++ K+K
Sbjct: 276 LKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK 335
Query: 777 HLQDDNNLLKQQ---LKDFQNHLNHV-----VDGLVRPEEVAARVDELRRKL-KLGTGEM 827
HL+D L+ Q LKD ++N++ +D +E ++L K+ +L +
Sbjct: 336 HLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKE 395
Query: 828 NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE-- 885
+ L LA L KQF + + R+ ++E+ +E L + L+ ++E
Sbjct: 396 EQGCVIEKLKSELAGLNKQFCYTV--EQHNREVQSLKEQHQKEISELNETFLSDSEKEKL 453
Query: 886 --------FRQACE----RALEARMNFDKRQHEARIQQME--NEIHYLQENLKSMEEIQG 931
++ CE EA +N++ + I Q E + + +SM++ Q
Sbjct: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 932 LTDLQLQE----ADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
+LQ+ A EK+ +L + L+ + E SQ++ L EL+ K + +
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGEN--EKLLSQQE---LVPELENTIKNLQEKN 568
Query: 988 KLATAELTIAKDQLKSLHGTVMKINQERAEEL-------QEAERFSRKAAQAARDLTRAE 1040
+ L+ LK L G + + +E+ + + +E + F +K + R +
Sbjct: 569 GVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELG 628
Query: 1041 AEIE---LLQNLLRQKGEQFRLEMEKTGVGTGANSQVLE-----IEKLNETMERQRTEIA 1092
++E + L QK + +E+T N Q LE ++ L+E E E+
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVK 688
Query: 1093 RLQNVLDLTGSDNK 1106
L + S+ K
Sbjct: 689 SLYEENNKLSSEKK 702
Score = 94.4 bits (233), Expect = 1e-18
Identities = 172/915 (18%), Positives = 375/915 (40%), Gaps = 152/915 (16%)
Query: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
+L+E ++ ++ LEK M++ + L + E+K+ + N L E +KQ +L+
Sbjct: 655 TLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE---KKQLSRDLEVF 711
Query: 328 LNTKNE-LLKQKTIELTRACQKQYELEQEL-------AFYKIDAKFEPLNYYPSEYAEID 379
L+ K + +LK+ +L + Q E + L K+ K + + +E+
Sbjct: 712 LSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVS 771
Query: 380 KAPDESPY------IGKSRYKRN------MFATESYIIDSAQAVQIKKMEPDEQLRNDHM 427
+ +E +G+S K N F + +++ + ++ + E Q
Sbjct: 772 EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE--- 828
Query: 428 NLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKIS 487
L + L D E++ + L E+ E E + +L E K E +L+
Sbjct: 829 -------LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLL----EMKNANEKTRLE--- 874
Query: 488 EAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKD 547
++LL + V ++ Q E+ EK+K I KE ++L+ ++ + +D
Sbjct: 875 --NQNLLIQ--------VEEVSQTCSKSEIHNEKEKCFI----KEHENLKPLLEQKELRD 920
Query: 548 PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
+ + + K + + N S + E+ +I +E K+ EE++ + ++ A
Sbjct: 921 -RRAELILLKDSLAKSPSVKNDPL----SSVKELEEKIENLEKECKEKEEKINKIKLVAV 975
Query: 608 EALKKDLEG---VISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
+A KK+L+ ++E L +++ + Q R L E+ L E E++ +QL+
Sbjct: 976 KA-KKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
Query: 665 IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNL---------- 714
+ A N + +L L+ ++ DL A L++ L
Sbjct: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094
Query: 715 ------RDAEANQLKEE---LEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
++ EA +L++E E T + +LE+ LQ +L+KE++ L+ + + + ++
Sbjct: 1095 AKAMVDKELEAEKLQKEQKIKEHATTVNELEE--LQVQLQKEKKQLQKTMQELELVKKDA 1152
Query: 766 QENS--------------ELHAKL-------KHLQDDNNLLKQQLKDFQNHLNHVVDGLV 804
Q+ + EL+ KL + L+ + + KQ+ + Q + + +
Sbjct: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212
Query: 805 RPEEVAARVDELRRKLKLGTGEM------NIHSPSDVLGKSLADLQK------QFSEILA 852
+ EE ++ +L K K + ++ + + G+ A Q+ Q +EI +
Sbjct: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1272
Query: 853 RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARI--- 909
+ + + Q ++ Q+++ QEE R A +A +A + + ++ R+
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA--KAEQATVTSEFESYKVRVHNV 1330
Query: 910 -QQMEN------EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL-- 960
+Q +N E ++ + +E + ++LQ++ + +++L+ L+ +
Sbjct: 1331 LKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLL 1390
Query: 961 -EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL 1019
K ++ + EL++ ++ + + + +E T QL S + + +++ L
Sbjct: 1391 ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450
Query: 1020 QEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEK 1079
QE R + + Q Q L + + + F+L+ E T S V +
Sbjct: 1451 QEEHRKTVETLQ---------------QQLSKMEAQLFQLKNEPT-----TRSPVSSQQS 1490
Query: 1080 LNETMERQRTEIARL 1094
L ER+ T++ L
Sbjct: 1491 LKNLRERRNTDLPLL 1505
Score = 87.0 bits (214), Expect = 2e-16
Identities = 234/1062 (22%), Positives = 425/1062 (40%), Gaps = 222/1062 (20%)
Query: 245 RSLESLEGQPVT--TQDRQEAF-ERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIK 301
+ +E L +PVT T D +A ER +E+ E + + ++ E +K KQ +
Sbjct: 53 KEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQ-------E 105
Query: 302 NQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKT----------IELTRACQKQYE 351
+D + K L++ +K N KNEL+ ++ +L A Q E
Sbjct: 106 VEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLE 165
Query: 352 LEQELAFY---------------KIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRN 396
L ++L F KI FE Y + ++D DE K
Sbjct: 166 LSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK--QLDATTDEK--------KET 215
Query: 397 MFATESYIIDSAQAVQ--IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLS 454
+ ++ I ++Q Q I ++ +E L+ ++ L Q+E K+ A +L+
Sbjct: 216 VTQLQNIIEANSQHYQKNINSLQ-EELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274
Query: 455 ELHDEI----EKAEQQILRATE-EFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNK-- 507
EL + + E +E+ I + E E + L +A +L ++ + Q+VN+
Sbjct: 275 ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334
Query: 508 ----------------LRQEAL---DLELQMEKQKQEIAGK-QKEIKDLQIAIDSL---- 543
L+ E +L+L++E Q I + E +DL+ I+ L
Sbjct: 335 KHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAK 394
Query: 544 DSKDPKHSHMKAQKSGKEQQ-----------LDIMNKQYQQLESRLDE-ILSRIAKE--- 588
+ + +K++ +G +Q + + +Q+Q+ S L+E LS KE
Sbjct: 395 EEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT 454
Query: 589 -TEEIKDLEEQLTEGQIAANEAL--KKDLEGVISGLQEYLGTIKGQATQ----------- 634
EI+ L+EQ Q EA+ + L ++ LQ LG G+ +Q
Sbjct: 455 LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQAS 514
Query: 635 ----AQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690
Q + R EK+ LL+ + ++ E ++L + + + EL LQE++ V
Sbjct: 515 DVHELQQKLRTAFTEKDALLETVNRLQGENEKL----LSQQELVPELENTIKNLQEKNGV 570
Query: 691 N-ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK--------------VTRLTQL 735
SL Q L E ++ + +D N+LK E+ + L +
Sbjct: 571 YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630
Query: 736 EQSALQAELEKERQALKNALGKAQFSEEKEQENSELH-----------------AKLKHL 778
+ +Q E E++ + G + +EK+Q + +L A++K L
Sbjct: 631 VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690
Query: 779 QDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAAR--VDELRRKLKLGTGEMNIHSPSDVL 836
++NN L + K L L + E+V + + +L +KL+L E D L
Sbjct: 691 YEENNKLSSEKKQLSRDLEVF---LSQKEDVILKEHITQLEKKLQLMVEE------QDNL 741
Query: 837 GKSLAD--LQKQFSEILARSKWERDEAQVRERKLQEEM--ALQQ--EKLATGQEE----F 886
K L + +QK F + + ++V E ++++ LQ E LA EE
Sbjct: 742 NKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLA 801
Query: 887 RQACERALEARMNFDKRQHEARIQQMENEI---HYLQENL---KSMEEIQGLTD------ 934
Q E+ LE Q E+ +Q E + Y QE + K +EEIQ +
Sbjct: 802 FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL 861
Query: 935 LQLQEADE----EKERILAQLRELEKK-KKLEDAKSQEQVFGLDKE-LKKLKKAVATSDK 988
L+++ A+E E + +L Q+ E+ + K E +E+ F + E LK L + D+
Sbjct: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR 921
Query: 989 LATAELTIAKDQL--------------KSLHGTVMKINQERAEELQEAERFSRKAAQAAR 1034
AEL + KD L K L + + +E E+ ++ + A +A +
Sbjct: 922 --RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKK 979
Query: 1035 DLTRAEAEIELLQNLLRQ-KGEQFRLEMEKTGVGTGANSQ---VLEIEKLNETMERQRTE 1090
+L + E + ++ L + E+ +L + GA S +LE EK +E ++ ++
Sbjct: 980 ELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK-- 1037
Query: 1091 IARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISS 1132
+ FE+ +E++ R + Q + I+S
Sbjct: 1038 -------------ERANNFEHRIEDLTRQLRNSTLQCETINS 1066
Score = 50.1 bits (118), Expect = 3e-05
Identities = 50/221 (22%), Positives = 102/221 (46%), Gaps = 26/221 (11%)
Query: 906 EARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKS 965
++R ++E EI E L+S +G D+ ++ E + +L LE A++
Sbjct: 45 KSRCTELEKEI----EELRSKPVTEGTGDI-IKALTERLDALL-----------LEKAET 88
Query: 966 QEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLH-GTVMKINQERAEELQEAER 1024
++Q L KE K+K+ V S ++ A +L+ H V +I + E + +
Sbjct: 89 EQQCLSLKKENIKMKQEVEDS----VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 1025 FSRKAAQAARDLTRA-EAEIELLQNLLRQKGEQF---RLEMEKTGVGTGANSQVLEIEK- 1079
+S A + L A ++EL + L Q + +L+ E + G Q+L ++K
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204
Query: 1080 LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELR 1120
L+ T + ++ + +LQN+++ + ++ EE+ +L+
Sbjct: 205 LDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLK 245
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 159 bits (401), Expect = 4e-38
Identities = 199/918 (21%), Positives = 398/918 (43%), Gaps = 130/918 (14%)
Query: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
E E+ RL + +S + + + + +EK + L+ +D L Q K LE + EL
Sbjct: 238 EREIERLSVALDGGRSP--DVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELM 295
Query: 1382 RTVQKRQQQKDFIDGNVESLMTEL----EIEKSLKHHEDIV-----DEIECIEKTLLKRR 1432
T + + + E L EL ++ + L+ H++ V E+ +K + ++
Sbjct: 296 ETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKL 355
Query: 1433 SELREADRLLAEAESELS-CTKEKTKNAVEKF--TDAKRSLLQTESDAEELERRAQETAV 1489
SE+++ + +A+ + EL+ C KEK + + E +D + + Q E + + L ++ + AV
Sbjct: 356 SEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAV 415
Query: 1490 N----------------LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDF 1533
+ + D+ L K +E+ + ++ L+ + I+ +
Sbjct: 416 TERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCST 475
Query: 1534 QCLSKKKEKL--TEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKR-------AELEK 1584
+++K + T E +I R D ++L+ E ++ + AE +K
Sbjct: 476 SYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDK 535
Query: 1585 LKSQVTSQQQEMAVLDRQ------------LGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
L Q+E++ L ++ L K++EL L + A+ +EALR
Sbjct: 536 LSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAE---KEALR--- 589
Query: 1633 TEVTEKCNHIREV--------KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
EK HI EV + +E L+ +L + E K+++ ++K+ IE E L
Sbjct: 590 ----EKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL 645
Query: 1685 QVVLRQMSK---HKTELKNILDMLQLENHELQGLKLQHDQRVS----ELE--KTQVAVLE 1735
+V ++ S + K ++ L++ N +LQ + R+S ELE + Q+ +LE
Sbjct: 646 KVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILE 705
Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
EK++ NL+ SQ + E+ ++ + + KEK+ LQE
Sbjct: 706 EKIDELNLKMTSQDE-----------------------EAHVMKKTIGVIDKEKDFLQET 742
Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
D +K+A + LA E+ + + + E +V +L++ L +R+ SL + A
Sbjct: 743 VDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAA 802
Query: 1856 QQQLQE---KREAV----NSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI 1908
++L E RE LQ++LA + +L + ++ + S + ++
Sbjct: 803 HKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEV 862
Query: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
S W + +KE + + Q+L N E+ ++K Q E ++ E S ++T +
Sbjct: 863 SRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLS----IDTER 918
Query: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
L+E+ LEKE+ + + S++ + + + L+EE R E + T+ L
Sbjct: 919 RHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR 978
Query: 2029 E-----------REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
E QQL K+ E + E ++++++ LL+ Q ER V +L+
Sbjct: 979 ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHT----VKNLE 1034
Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQ--KEMATIELVAQDNHERARRLMK-ELNQMQYEYT 2134
L R + + L ++++ IQ KE T+ + R +++ ++ Q+Q +Y
Sbjct: 1035 SLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYD 1094
Query: 2135 ELKKQMANQKDLERRQME 2152
LK+Q++ ++ R ++
Sbjct: 1095 ALKRQISTERYERERAIQ 1112
Score = 125 bits (313), Expect = 6e-28
Identities = 208/1023 (20%), Positives = 429/1023 (41%), Gaps = 183/1023 (17%)
Query: 1353 EKEMEELHHNIDDLLQEKKS-LECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSL 1411
EK +L H + L Q K S ++ E E + + + + E+ LE+ K
Sbjct: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
Query: 1412 KHHEDIVDEIECIEKTLLKRRSELR-----EADRL-LAEAESE-----LSCTKEKTKNAV 1460
+H + V E++ K + ++L+ A +L L E ES+ + +EK +AV
Sbjct: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
Query: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVN---------------LVKADQQLRSLQADA 1505
+ K+ + +++ + V+ L AD +++ LQ +
Sbjct: 154 VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213
Query: 1506 KDLEQHKIKQEEILKEINKIVAAKDSDFQCLS------------------KKKEKLTEEL 1547
L++ E +++ +K + ++ + + LS K EKL L
Sbjct: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273
Query: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607
++ A ++ + ++ L E++ + ++ L ++ + E+ L +QL K
Sbjct: 274 NIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHK 333
Query: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER- 1666
EE+ + A +L EA + E+ K + +++++ + +L ELN+ E+
Sbjct: 334 EEV------LETADKELGEAKK----EIKRKLSEMQDLEETMAKLQL---ELNLCQKEKE 380
Query: 1667 --------KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQ 1718
K+ L + ++E+E++ L + + + +L ++ ++LE+ G+K +
Sbjct: 381 RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEH----GIK-R 435
Query: 1719 HDQRVSELEKTQVAVLEE----KLELENLQQISQQ-------------------QKGEIE 1755
D+ S L+ + EE K ELE LQ I Q+ +KG+
Sbjct: 436 RDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYN 495
Query: 1756 WQKQLLERDKREIERMTAESRA----LQSCVECLSKEKEDL-------QEKCDIWEKKLA 1804
+ + R++ E++RM +QS V+ L+ E++ L QE+ K+
Sbjct: 496 SEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555
Query: 1805 QTK---RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI-------SA 1854
QT +++ E+ ++ S+L ++ L+++L+ + L +++ +
Sbjct: 556 QTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTC 615
Query: 1855 MQQQLQEKREAVNS----LQEELANVQDHLNLAKQDLLHT---TKHQDVLLSE----QTR 1903
+ QL+ ++ + S ++E + ++++ L + Q H + HQ ++ +
Sbjct: 616 VNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQ 675
Query: 1904 LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK 1963
LQ+ + ++ +R + E E+ Q Q+++L+ +I+E LK+ Q+ EE+
Sbjct: 676 LQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD------------EEAH 723
Query: 1964 LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQT 2023
+ + + +++ +E D+K+ E++ LQE + EK ++Q
Sbjct: 724 VMKKTIGVIDKEKDFLQETVDEKT-------------EKIANLQEN---LANKEKAVAQM 767
Query: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
K +SE E + + L+ +E +S LR Q K+ ++ S + A K
Sbjct: 768 KIMISECESSVNQLKETLVNRDREINS-------LRRQLDAAHKELDEVGRSREIAFKEN 820
Query: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQM-QYEYTELKKQMAN 2142
R +L+ +L +EN I E +E Q+ E R+ K + ++ ++E K+ N
Sbjct: 821 R-RLQDDLATMARENQEISLE---LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKEN 876
Query: 2143 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 2202
Q L+R QM + A + E +S L +L +I +L +E
Sbjct: 877 QDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRL---------ELLSIDTERRHLRERVEL 927
Query: 2203 LKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEV 2262
L++ + +N E S M L E+LRH+ED KA + + +S E+
Sbjct: 928 LEKEIQEHINAHHAYESQISSMAKAMSR------LEEELRHQEDE-KATVLNDLSSLREL 980
Query: 2263 LIK 2265
IK
Sbjct: 981 CIK 983
Score = 105 bits (263), Expect = 4e-22
Identities = 148/803 (18%), Positives = 363/803 (45%), Gaps = 86/803 (10%)
Query: 1317 EHHNLENEVSRLE---DIMQHLKSKKREERWMRASKR----QSEKEMEELHHNIDDLLQE 1369
E +LE +++L+ ++ Q K + +E +++ Q E+E + L ++
Sbjct: 357 EMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT 416
Query: 1370 KKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI-EKSLKHHEDIVDEIECIEK 1426
++ L EVE L +++R + +D ++ + E + +K L+ + I+ C
Sbjct: 417 ERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTS 476
Query: 1427 TLLKRRSEL-READRLLAEAE-SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
+ +S + R ++ +E +++ +++ + +E+F ++ + +S+ + L
Sbjct: 477 YSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERF---EKYMEDIQSNVKLLTAER 533
Query: 1485 QETAVNLVKADQQLRSLQADA-KDLEQHKI-----KQEEI-LKEINKIVAAKDSDFQCLS 1537
+ +V +A ++L +L+ ++ + H I K++E+ L ++ +I+A K++ + L
Sbjct: 534 DKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLE 593
Query: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLK---ESEVLLQAKRAELEKLKSQVTSQQQ 1594
+E +L+K IE +H L+ K +S+VL+ + +E L++++ Q Q
Sbjct: 594 HIEEVSLFGKSELEKTIEHLTC-VNHQLESEKYELKSKVLIM--KETIESLENKLKVQAQ 650
Query: 1595 EMAVLDRQLGHKKEE---LHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
+ + + H+K E L ++ + ++ D Q L + E+ I+ ++ ++E
Sbjct: 651 KFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDE 710
Query: 1652 LSFQKGELNVQISERKTQLTLIKQEI--------EKEEE--NLQVVLRQMSKHKTELKNI 1701
L+ + + + K + +I +E EK E+ NLQ L K ++K +
Sbjct: 711 LNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIM 770
Query: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
+ + ++L+ + D+ ++ L + A +E E+ ++I+ ++ ++ +
Sbjct: 771 ISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATM 830
Query: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
R+ +EI S L++ V+ EKE+++ + + ++++ + ++AA E+ ++
Sbjct: 831 ARENQEI------SLELEAAVQ----EKEEMKSRVHKYITEVSRWESLMAAKEKENQDLL 880
Query: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
+ L + + Q + S+ ++ ++ + + RE V L++E +Q+H+N
Sbjct: 881 DRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKE---IQEHIN 937
Query: 1882 L--AKQDLLHTTKHQDVLLSEQTRLQKD-----ISEWANRFEDCQKEEETKQQQLQVLQN 1934
A + + + L E+ R Q+D +++ ++ E C K + K Q L +
Sbjct: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997
Query: 1935 EIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLS 1994
+ + F+R+ E E+ +S+ + K L ++H ++ + + D+
Sbjct: 998 K-----------NLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFH 1046
Query: 1995 KVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD 2054
L + E+ + + K +L+ E +L +S E L+ + ++ D
Sbjct: 1047 SHLTSHEK--------------DTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTD 1092
Query: 2055 FSLLRNQFLTERKKAEKQVASLK 2077
+ L+ Q TER + E+ + ++
Sbjct: 1093 YDALKRQISTERYERERAIQEMR 1115
Score = 82.0 bits (201), Expect = 6e-15
Identities = 169/824 (20%), Positives = 339/824 (41%), Gaps = 147/824 (17%)
Query: 322 EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKID-AKFEPLNYYPSEYAEIDK 380
E+L SDL E L+Q + +A ++ + L YK++ A+ N Y E+ K
Sbjct: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENN--ELYLELMK 91
Query: 381 APDESP-YIGKSRYKRNMFATESY---IIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
+ S ++ + + A E+ +++ A ++K +E + + +N+ +
Sbjct: 92 LREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQ-------- 143
Query: 437 TQLEDKEKKISAAQTRLSELHDEIEK--AEQQILRATEEFKQLEEAIQLKKISEAG---- 490
QL++K LH ++ +++ + + Q++E + ++S
Sbjct: 144 -QLQEKN------------LHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQP 190
Query: 491 -----KDLLY---KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
DLL ++ Q V++L+++ +E + ++I +++EI+ L +A+D
Sbjct: 191 DDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDG 250
Query: 543 LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
+ P ++++ E+ + +N Q L+ + KDLE+++ E
Sbjct: 251 --GRSPDVLSLESRNKTNEKLIAHLNIQVDFLQ--------------QANKDLEKRIRE- 293
Query: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
L E T+ + N + E L Q LTE++Q Q
Sbjct: 294 ------------------LMETKETVTSEVVNLSN-------KNEKLCQELTEIDQLAQQ 328
Query: 663 LEIVAMDA-ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQ 721
LE + E KEL E + E+ L + Q DL A+L+ LNL E +
Sbjct: 329 LERHKEEVLETADKELGEAKK------EIKRKLSEMQ-DLEETMAKLQLELNLCQKEKER 381
Query: 722 LKEEL----EKVTRLTQLEQ--------------SALQAELEKERQALKNALGKAQFSEE 763
L +EL + T + QLEQ + Q LE ER L++ + +
Sbjct: 382 LSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGI------KR 435
Query: 764 KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAAR-VDELRRKLKL 822
+++ S L LK ++++ + K++L+ L H++ +AR + R +
Sbjct: 436 RDRSPSRLDTFLKGIEEERDYYKKELE----RLQHIIQRRSCSTSYSAREKSSIFRTPEK 491
Query: 823 GTGEMNIHS---PSDVLGKSLADLQKQFSEILARSKW---ERDEAQVRERKLQEEMALQQ 876
G IH D L + L +K +I + K ERD+ V + QEE++
Sbjct: 492 GDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS--- 548
Query: 877 EKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQ 936
A +E + + + M +K + ++++ E L+E L+ +EE+ +
Sbjct: 549 ---ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605
Query: 937 LQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTI 996
L++ E + QL + + K + +E + L+ +L K A + +
Sbjct: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL----KVQAQKFSHVAGDSSH 661
Query: 997 AKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
K ++ SL +I E+ + + + + + + +L A+A+I++L+ + + +
Sbjct: 662 QKTEVNSL-----RIVNEQLQ--RSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLK 714
Query: 1057 FRLEMEKTGVGTGANSQVLEIEK--LNETMERQRTEIARLQNVL 1098
+ E+ V V++ EK L ET++ + +IA LQ L
Sbjct: 715 MTSQDEEAHV-MKKTIGVIDKEKDFLQETVDEKTEKIANLQENL 757
Score = 81.6 bits (200), Expect = 8e-15
Identities = 171/877 (19%), Positives = 361/877 (41%), Gaps = 141/877 (16%)
Query: 257 TQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ-DKLNKSLKEEAM 315
T ++ A ++ +++ +DLEK++ E E K T + + N+ +KL + L E
Sbjct: 265 TNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQ 324
Query: 316 LQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEY 375
L +Q + L T ++ L + E+ R + +LE+ +A +++ LN E
Sbjct: 325 LAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLE-----LNLCQKEK 379
Query: 376 AEID-----KAPDESPYIGKSRYKRNMF-ATESYIIDSAQ-AVQIKKMEPDEQLRNDHMN 428
+ K+ E+ + K+ + ES+ + Q +++++M + ++
Sbjct: 380 ERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRD-- 437
Query: 429 LRGHTPLDTQLEDKEKKISAAQTRL----------------------------------S 454
R + LDT L+ E++ + L S
Sbjct: 438 -RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNS 496
Query: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLK-KISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
E+H +I + ++ R E F++ E IQ K+ A +D L + + ++ LR+E+
Sbjct: 497 EIH-QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555
Query: 514 ------DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQ 563
++ MEK+K E+A + DL+ + ++ K H++ KS E+
Sbjct: 556 QTTAPHNIVSLMEKEK-ELA-----LSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT 609
Query: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL----------------TEGQIAAN 607
++ + QLES E+ S++ E I+ LE +L + ++ +
Sbjct: 610 IEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSL 669
Query: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
+ + L+ + Q L +G+ AQ + + L ++ + L ++T ++E ++
Sbjct: 670 RIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEE---AHVMK 726
Query: 668 MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE--- 724
+ KE L+ + E+ E A+LQ+ + A+++ ++ ++ NQLKE
Sbjct: 727 KTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLV 786
Query: 725 ------------------ELEKVTRLTQL---EQSALQ---AELEKERQALKNALGKAQF 760
EL++V R ++ E LQ A + +E Q + L A
Sbjct: 787 NRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAA-- 844
Query: 761 SEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHL-------NHVVDGLVRPEEVAARV 813
+EKE+ S +H + + +L+ + K+ Q+ L N D V+ +
Sbjct: 845 VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904
Query: 814 DELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE-ILARSKWERDEAQVRE--RKLQE 870
+R +L ++I + L + + L+K+ E I A +E + + + +L+E
Sbjct: 905 SSVRLEL------LSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEE 958
Query: 871 EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQ 930
E+ Q+++ AT + E ++ D QQ+ ++ + + +E ++
Sbjct: 959 ELRHQEDEKATVLNDLSSLRELCIKLDSGKD-----IMTQQLNSKNLEFERVVVELENVK 1013
Query: 931 GLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA 990
+DL ++ E+ + L L + ++ S D E++ LK+ + S+
Sbjct: 1014 SESDLLKKQLSNERHTV-KNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKL 1072
Query: 991 TA---ELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
T+ E T+ + ++ L + ++ + E E ER
Sbjct: 1073 TSQSRENTMLRAKVAQLQTDYDALKRQISTERYERER 1109
Score = 47.4 bits (111), Expect = 2e-04
Identities = 50/220 (22%), Positives = 91/220 (41%), Gaps = 20/220 (9%)
Query: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQE 967
RIQ+++ E+H LQE L ME G+ D Q I + RE+E+ D
Sbjct: 205 RIQELQQEVHQLQEKLAMME--SGVRDYSKQ--------IELREREIERLSVALDGGRSP 254
Query: 968 QVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSR 1027
V L+ K +K +A ++ + K L + ++ + + E S
Sbjct: 255 DVLSLESRNKTNEKLIAH----LNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSN 310
Query: 1028 KAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVL-EIEKLNETMER 1086
K + ++LT + +L Q L R K E ++ G + L E++ L ETM +
Sbjct: 311 KNEKLCQELTEID---QLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAK 367
Query: 1087 QRTEIARLQNVLDLTGSD--NKGGFENVLEEIAELRREVS 1124
+ E+ Q + + K E V+ ++ + ++ +S
Sbjct: 368 LQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLS 407
Score = 47.0 bits (110), Expect = 2e-04
Identities = 108/563 (19%), Positives = 229/563 (40%), Gaps = 65/563 (11%)
Query: 567 MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLG 626
+ ++Y + RLD++ R T E L E+L + E+L++
Sbjct: 5 VERKYINIRKRLDQLGYRQTL-TVECLPLVEKLFSDLVHTTESLRQS------------- 50
Query: 627 TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA-ENMRKELAELESALQ 685
K A +A+ E E + +E ++L + M E+ + + EL+++L+
Sbjct: 51 --KLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLK 108
Query: 686 EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE-LEKVTRLTQLEQSALQAEL 744
+ A L+ + LE ++ QL+E+ L V + ++ ++
Sbjct: 109 KCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIA--F 166
Query: 745 EKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQDDN-NLLKQQLKDFQNHLNHVVDG 802
++R + + ++ S Q + A L + D+ L+Q++ Q L + G
Sbjct: 167 RRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESG 226
Query: 803 LVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
+ + + +++ R+++ + ++ DVL SL K +++A + D Q
Sbjct: 227 V---RDYSKQIELREREIERLSVALDGGRSPDVL--SLESRNKTNEKLIAHLNIQVDFLQ 281
Query: 863 VRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQEN 922
+ L++ + E + E +N + ++ Q EI L +
Sbjct: 282 QANKDLEKRI-----------RELMETKETVTSEVVNLSNKNE--KLCQELTEIDQLAQQ 328
Query: 923 L-KSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKK 981
L + EE+ D +L EA +E +R L+++++LE+ AK Q ++ KE ++L
Sbjct: 329 LERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETM----AKLQLELNLCQKEKERL-- 382
Query: 982 AVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEA 1041
SD+L + K L+++ V ++ QE+ ++ E F A R LT
Sbjct: 383 ----SDEL------LVKSDLETV---VHQLEQEKQRLSKKVESF----AVTERQLTLEVE 425
Query: 1042 EIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIA-RLQNVLDL 1100
+ L + R+ RL+ G+ + E+E+L ++R+ + + +
Sbjct: 426 RMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSI 485
Query: 1101 TGSDNKGGFENVLEEIAELRREV 1123
+ KG + + + +I R E+
Sbjct: 486 FRTPEKGDYNSEIHQITRERDEL 508
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 157 bits (398), Expect = 9e-38
Identities = 219/1048 (20%), Positives = 447/1048 (42%), Gaps = 124/1048 (11%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + + ++ + A KR+ E E EL +IDDL +E E V+
Sbjct: 923 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 982
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
++ +D + L E +K+L+ H+ +D+++ E TL K + +L ++ D
Sbjct: 983 NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
L E E +L E+ K +E A+ S++ E++ ++L+ + ++ + +
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Query: 1498 LRSLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
+ QA L Q KIK+ + ++E+ + + A+ + K++ L+ EL+++ + +E
Sbjct: 1100 IEDEQALGIQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQQ 1594
A +++ K+ E Q R +LE+ L Q+ + Q+
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 1595 EMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
L+++ K E+ L ++ +AK +L++ R E +++E + E + L+ +
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL------KNIL-DM 1704
L+ Q+G L + E QL + + + Q +Q+ + K +L KN L
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 1705 LQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIE 1755
LQ H+ L+ Q++ QR T+VA K E + +Q+ + ++ + +
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398
Query: 1756 WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ-------EKCDIWEKKLAQTKR 1808
Q L+ + +E + A+ +L+ + L E EDL C +KK +
Sbjct: 1399 LA-QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 1809 VLAAAEENSKMEQSNLEKLELNVRKL-----------QQELDQLN---RDKLSLHNDISA 1854
+LA ++ + + LE + R L ++ LDQL R+ +L +IS
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 1855 MQQQLQEKREAVNSLQEELANVQD---HLNLAKQDLLHTTKHQD-VLLSEQTRLQKDISE 1910
+ +Q+ E + ++ L++ V+ L A ++ + +H++ +L Q L + SE
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
+ +K+EE Q ++ N +++V E M L E S + K
Sbjct: 1578 VDRKI--AEKDEEIDQ---------LKRNHIRIV--ESMQSTLDAEIRSRNDAIRLKK-- 1622
Query: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
++E +L + + +L+ A E +R + + + + L R +
Sbjct: 1623 ------KMEGDLNEMEIQLNHANR---MAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673
Query: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKN 2090
++QL LQ E + +RA Q RK AE+++ E +++ +Q
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASERVQLLHTQNTSL 1729
Query: 2091 LLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQ 2150
+ +K+ + I + +E + Q+ + K + ELKK+ LER +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1789
Query: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT 2210
+ ++ L+ + + + +LK + + +L A R LEGE+ES ++
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA-------RVRELEGEVESEQKRNAEA 1842
Query: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQT 2270
+ +G + + ++ E R LR L+ D+L+A+++ +QAE + + Q+
Sbjct: 1843 V-KGLRKHERRVKELTYQTEEDRKNILR--LQDLVDKLQAKVK-SYKRQAE---EAEEQS 1895
Query: 2271 EGTLHSLRRQVDALGELVTSTSADSASS 2298
L R+ L E AD A S
Sbjct: 1896 NTNLAKFRKLQHELEE--AEERADIAES 1921
Score = 154 bits (390), Expect = 7e-37
Identities = 202/1027 (19%), Positives = 445/1027 (43%), Gaps = 126/1027 (12%)
Query: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
++ L+ E EK + + +E + I+ L K ++ +E + + E + + + +
Sbjct: 842 IKPLLKSAETEKEMA---TMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898
Query: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
E DA+ Q +LE + +E ++ L A + LE + ++
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958
Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESEV 1573
+ ++ +A + + K + LTEE+ L + I + ++ H Q L +
Sbjct: 959 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD--- 1015
Query: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633
LQA+ ++ L +Q++ L+ L +K+ L+ + +AK L+ L+L +
Sbjct: 1016 -LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK----LRMDLERAKRKLEGDLKLAQE 1070
Query: 1634 EVTEKCNHIREVKSLLEELSFQKG--------------ELNVQISERKTQLTLIKQEIEK 1679
+ + N +++ L++ F+ +L +I E + ++ +++EIE
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 1680 EEENLQVVLRQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSELE 1727
E + +Q S EL+ I + L Q+E E + K++ D + L+
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
A K +++ ++ +Q ++ KQ LE++K E M E L S VE +SK
Sbjct: 1191 HEATAATLRKKHADSVAELG-EQIDNLQRVKQKLEKEKSE---MKMEIDDLASNVETVSK 1246
Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ---SNLEKLELNVRKLQQELD----- 1839
K +L++ C E +L++ K + EE ++ + +L+ + ++LD
Sbjct: 1247 AKGNLEKMCRTLEDQLSELK---SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303
Query: 1840 --QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
QL+R K + I +++QL+E+ +A N+L L + + +L ++ + + L
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 1898 LSEQTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMM 1949
++ ++++W ++E Q+ EE ++ Q+LQ + +E K E
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 1950 FQRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
QRLQ E E + + + L ++Q +K L + K K ++ +++ A+++ R+L
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 2007 -----------QEEERWCESLEKTLSQTKRQLSEREQQLVE---KSGELLALQKEADSMR 2052
+E E+L++ ++++S+ +Q+ E + EL ++K+ + +
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543
Query: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI---- 2108
+ + + E ++ ++ L +S++++ + E+ +E +++ I
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603
Query: 2109 ------ELVAQDNHERARRLMK-ELNQMQYEYTELKKQMA--------NQKDLERRQMEI 2153
E+ ++++ R ++ M+ +LN+M+ + + A Q L+ Q+ +
Sbjct: 1604 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL 1663
Query: 2154 SDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NL 2207
DA+R+ + ++K+++ + N E+ +L A LE+ E E EL E L
Sbjct: 1664 DDALRS-QEDLKEQLAMVERRANLLQAEI-EELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 2208 PFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAE 2261
T N K + I E + ++ R+ E++ K A + + K+ +
Sbjct: 1722 LHTQNTSLINTKKKL-ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780
Query: 2262 V---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQN 2317
L + K+ E T+ L+ ++D +L A + +LE+ + E + ++
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQL-----ALKGGKKQIQKLEARVRELEGEVESE 1835
Query: 2318 QEKNASA 2324
Q++NA A
Sbjct: 1836 QKRNAEA 1842
Score = 120 bits (301), Expect = 2e-26
Identities = 175/858 (20%), Positives = 359/858 (41%), Gaps = 142/858 (16%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRAS--KRQSE--KEMEELHHNIDDL-------LQE 1369
L+ ++ L+ ++ L+ + ER RA K++S+ +E+EE+ +++ ++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 1370 KKSLECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSL 1411
K E E +++ R +++ R++ D + N++ + +LE EKS
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
E +D++ +T+ K + L + R L + SEL +E+ + + T A+R L
Sbjct: 1230 MKME--IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT-AQRGRL 1286
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
QTES + +E V+ Q R QA + +E+ K + EE +K N + A S
Sbjct: 1287 QTESGEFSRQLDEKEALVS-----QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 1532 ---DFQCLSKKKEKLTEELQKLQKDI-----EMAERNEDHHLQVLKESEVLLQAKRAELE 1583
D L ++ E+ E +LQ+ + E+A+ + ++ +E L +AK+
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK---- 1397
Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1643
KL ++ + ++ + ++ + ++ LQ + D++ ++ N +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 1644 EVKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
+ ++ EL E + T+L IK E+ + L+ + R+ + E+ +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 1701 ILDMLQLEN---HELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGE 1753
+ + + HEL+ +K Q +Q EL E+ + ++ E+ ++ +Q Q K E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 1754 IEWQKQLLERDK----------REIERMT----AESRALQSCVECLSKEKEDLQEKCDIW 1799
++ +++ E+D+ R +E M AE R+ + K + DL E
Sbjct: 1578 VD--RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM---- 1631
Query: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
E +L R+ A A N + Q L+ +++ LD R + L ++ ++++
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIH-------LDDALRSQEDLKEQLAMVERRA 1684
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEWA 1912
+ + L+ L + +A+Q+LL ++ +L ++ T +L+ DIS+
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSKV 1969
ED LQ +N E+ K + MM + L+KE+++ E + +
Sbjct: 1745 GEMEDI----------LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1794
Query: 1970 TLKEQQ-------------------------HQLEKELTDQKSKLDQVLSKVLAAEERVR 2004
T+K+ Q +LE E+ ++ + + + + E RV+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854
Query: 2005 TLQ---EEER--------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
L EE+R + L+ + KRQ E E+Q + LQ E +
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914
Query: 2054 DFSLLRNQFLTERKKAEK 2071
+ +Q R K+ +
Sbjct: 1915 RADIAESQVNKLRVKSRE 1932
Score = 117 bits (292), Expect = 2e-25
Identities = 209/981 (21%), Positives = 397/981 (40%), Gaps = 169/981 (17%)
Query: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK--KMIETE-ELKSKQTRFLEEIKNQD 304
+ LE + VT + + E E L E+ ++I+T+ +L++K E ++++
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936
Query: 305 KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
++N L + + C ELK D++ +ELT A + E E+ K+
Sbjct: 937 EINAELTAKKRKLEDECSELKKDID---------DLELTLA---KVEKEKHATENKVKNL 984
Query: 365 FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIK-------KME 417
E + A++ K K+ + +D QA + K K++
Sbjct: 985 TEEMAGLDETIAKLTKE------------KKALQEAHQQTLDDLQAEEDKVNTLTKAKIK 1032
Query: 418 PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
++Q+ + L+ LE ++K + +L +++ A++ I+ E +QL
Sbjct: 1033 LEQQVDD----------LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082
Query: 478 EEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ 537
+E +LKK K+ L +++ ++AL ++L QK+IK+LQ
Sbjct: 1083 DE--KLKK-----KEFEISNLQSKIE-----DEQALGIQL------------QKKIKELQ 1118
Query: 538 IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK---- 593
I+ L+ + +A ++ E+Q ++++ +++ RL+E + + E K
Sbjct: 1119 ARIEELEEEIEAE---RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 594 -------DLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
DLEE + + A KK + V + L E + ++ + + E +++ E
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEI 1234
Query: 647 ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
+ L + V + + LE + E+ +L+EL+S +EQ + L +G L
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLED---QLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Query: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFS----- 761
E +L+ ++A +QL + T+ Q+E+ L+ +LE+E +A KNAL A S
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQ--QIEE--LKRQLEEEIKA-KNALAHALQSSRHDC 1346
Query: 762 -------EEKEQENSELHAKL----------------------KHLQDDNNLLKQQLKDF 792
EE+++ +EL L + L++ L Q+L+
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 793 QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA 852
+ H+ V E+ R+ L L N +L Q+ F +ILA
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN------AACAALDKKQRNFDKILA 1460
Query: 853 RSKWERDEAQVRERKLQEE---MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARI 909
K + +E Q+E + + K+ EE E N + +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 910 QQME--NEIHYLQENLKSMEEIQGLTDLQLQEA----DEEKERILAQLRELEKKKKLEDA 963
Q E IH L++ K +E+ + L+EA + E+ +IL EL + K D
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 964 KSQEQVFGLDKELKKLK----KAVATSDKLATAELTIAKDQL---KSLHGTV--MKINQE 1014
K E+ D+E+ +LK + V + AE+ D + K + G + M+I
Sbjct: 1581 KIAEK----DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 1015 RAEEL-QEAERFSRK--------------AAQAARDLTRAEAEIELLQNLLRQKGEQFRL 1059
A + EA R R A ++ DL A +E NLL+ + E+ R
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 1060 EMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAE 1118
+E+T A ++L+ + + + Q T + + L+ S +G E++L+E
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756
Query: 1119 LRREVSYQNDYISSMADPFKR 1139
+ + MA+ K+
Sbjct: 1757 AEEKAKKAITDAAMMAEELKK 1777
Score = 114 bits (284), Expect = 1e-24
Identities = 149/714 (20%), Positives = 314/714 (43%), Gaps = 106/714 (14%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
NLE LED + LKSK+ E++ + + + Q+E ++++E + L +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLM---------------TELEIEKSL-K 1412
K++ ++EEL R +++ + K+ + ++S ++ E++++L K
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLAE----AE----------SELSCTKEKTKN 1458
+ ++ E ++R EL EA + LA+ AE + L TK++ +N
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 1459 AVEKF------TDAKRSLLQTESD-----AEELERRAQETAVNLVKADQQLRSLQADA-- 1505
VE T+A + L + E +++ +ET L + ++ RSL +
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 1506 -KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
K+ + + Q E LK NK + + SD + K EL+K++K +E E
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKCE 1545
Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
LQ L+E+E L+ + ++ +++ ++ + E+ DR++ K EE+ L+ + ++
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHIRIVES 1602
Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
+Q L + E+ + + IR K + L E+ Q N +E + ++
Sbjct: 1603 MQSTL---DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDT 1659
Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGL--KLQHDQRVSELEKTQVAVLE 1735
+ +L LR K +L + ++LQ E EL+ + + ++++E E +
Sbjct: 1660 QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1719
Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKE 1790
+ L +N I+ ++K E + + E + E AE +A ++ + K+++
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENS-----KMEQSNLEKLELNVRKLQQELDQLNRDK 1845
D + +K + QT + L + + K + ++KLE VR+L+ E++
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES----- 1834
Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
+ + EAV L++ V++ ++D + + QD++ +LQ
Sbjct: 1835 ------------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV----DKLQ 1878
Query: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ-KERE 1958
+ + + E+ +++ T + + LQ+E+EE + + E +L+ K RE
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 94.4 bits (233), Expect = 1e-18
Identities = 121/613 (19%), Positives = 248/613 (40%), Gaps = 87/613 (14%)
Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
C++ E + S+ E +Q SK E +W + + + EEL L Q
Sbjct: 1346 CDLLREQYEEEQESKAE--LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
++ E VE ++ ++ K + VE LM ++E ++K ++ + I+ E
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK 1463
Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
+E +K +EL + E+ +L K + KN ++ +D +
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLE----QHKIKQEEILKEINKIVA 1527
+ ELE+ ++ + L +A + E + +++ ++ E+++ +A
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV-----LKESEVLLQ-AKRAE 1581
KD + L + ++ E +Q D E+ RN+ L+ L E E+ L A R
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 1582 LEKLKSQVTSQQ-------------QEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEAL 1628
E L++ +Q + L QL + +LLQ + + +A L++
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702
Query: 1629 R---LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
R + E E+ + ++ + + L K +L IS+ + ++ I QE EE +
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762
Query: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL-----EKTQVAVLEEKLEL 1740
+ + ELK D + L+ +K +Q V +L E Q+A+ K ++
Sbjct: 1763 KAITDAAMMAEELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818
Query: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
+ L+ ++ +GE+E +++ R+ ++ + R ++ ++++++ D+ +
Sbjct: 1819 QKLEARVRELEGEVESEQK---RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875
Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
K A+ K AEE + +NL K RKLQ EL +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKF----RKLQHEL---------------------E 1910
Query: 1861 EKREAVNSLQEEL 1873
E E + + ++
Sbjct: 1911 EAEERADIAESQV 1923
Score = 90.5 bits (223), Expect = 2e-17
Identities = 132/695 (18%), Positives = 298/695 (42%), Gaps = 44/695 (6%)
Query: 1644 EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD 1703
++K LL+ +K +++ K + IK E+ K E + + +M T LK D
Sbjct: 841 KIKPLLKSAETEK-----EMATMKEEFQKIKDELAKSEAKRKELEEKMV---TLLKEKND 892
Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLER 1763
+ E +GL ++R +L KT++ + + E+ + ++ E+ +K+ LE
Sbjct: 893 LQLQVQAEAEGLA-DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 951
Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
+ E+++ + + VE KEK + K +++A +A + K Q
Sbjct: 952 ECSELKKDIDDLELTLAKVE---KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
++ +++ + +++ L + K+ L + ++ L+++++ L+ ++ L LA
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
++ ++ + L + + + +IS ++ ED Q Q++++ LQ IEE + ++
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 1944 VQQEMMFQRLQKERESEESKLETSKVTLKE------QQHQLEKELTDQKSKLDQVLSK-V 1996
+ + +K+R +LE L+E Q ++ K+ + K+ + L +
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 1997 LAAEERVRTLQEEE--------RWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
L E TL+++ ++L++ + +++ SE + ++ + + + + K
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
++ L +Q L+E K E++ L L QR +L+ E + + + ++ A +
Sbjct: 1249 GNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEALV 1304
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
+++ +++ +EL + E + K +A+ R ++ + E K E+
Sbjct: 1305 SQLSRGKQAFTQQI-EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 2169 RTSLKNLNQFLPELPADLEA-ILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHI 2227
+ +L N + + E ++R E LE + L + L E +N +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH---VEAVNAKCASL 1420
Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQA---EVLIKGKRQTEGT---LHSLRRQV 2281
R + E L +R A KQ ++L + K++ E T L + +++
Sbjct: 1421 EKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA 1480
Query: 2282 DALGELVTSTSADSASSPSLSQLESSLTEDSQLGQ 2316
+LG + +A SL QLE+ E+ L Q
Sbjct: 1481 RSLGTELFKIK--NAYEESLDQLETLKRENKNLQQ 1513
Score = 89.0 bits (219), Expect = 5e-17
Identities = 161/724 (22%), Positives = 323/724 (44%), Gaps = 119/724 (16%)
Query: 245 RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK-KMIETEELKSKQTRFLEEIKNQ 303
R + L Q Q F R L+E E L L + K T++++ + + EEIK +
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSR-QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332
Query: 304 DKLNKSL----------KEEAMLQKQSCEELKSDLNTKN-ELLKQKTIELTRACQKQYEL 352
+ L +L +E+ +++S EL+ L+ N E+ + +T T A Q+ EL
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 353 EQ---ELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID--- 406
E+ +LA ++ A E + ++ A ++K K R + + E ++D
Sbjct: 1393 EEAKKKLA-QRLQAAEEHVEAVNAKCASLEKT--------KQRLQNEV---EDLMLDVER 1440
Query: 407 --SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE 464
+A A KK +++ + T +LE +K+ + T L ++ + E++
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEET--HAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 465 QQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQ 522
Q+ E K L++ I ++I+E GK + + ++ ++ QE +L+ +E+
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-----KIKKQVEQEKCELQAALEEA 1553
Query: 523 KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY----QQLESRL 578
+ + ++ +I +Q+ ++ + S+ + + + K++++D + + + + ++S L
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSE------VDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607
Query: 579 D-EILSR-----IAKETE-EIKDLEEQLTEGQIAANEALK--KDLEGVISGLQEYLGTIK 629
D EI SR + K+ E ++ ++E QL A EAL+ ++ +G++ Q +L
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD--- 1664
Query: 630 GQATQAQNECRK---LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQE 686
A ++Q + ++ + + + LLQ E+E+ R LE + +EL + +Q
Sbjct: 1665 -DALRSQEDLKEQLAMVERRANLLQ--AEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 687 QHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEK 746
H N SL T+ L + + +Q++ E+E + Q A AE EK
Sbjct: 1722 LHTQNTSLINTKKKL--------------ETDISQMQGEMEDIL------QEARNAE-EK 1760
Query: 747 ERQALKNALGKAQFSEE--KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD--- 801
++A+ +A A +EE KEQ+ S HL+ ++Q +KD Q L+
Sbjct: 1761 AKKAITDA---AMMAEELKKEQDTSA------HLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 802 --GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLG-KSLADLQKQFSEILARSKWER 858
G + +++ ARV EL GE+ + K L +++ E+ ++
Sbjct: 1812 KGGKKQIQKLEARVRELE-------GEVESEQKRNAEAVKGLRKHERRVKELT----YQT 1860
Query: 859 DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHY 918
+E + +LQ+ + Q K+ + + + +A E++ F K QHE + +I
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE 1920
Query: 919 LQEN 922
Q N
Sbjct: 1921 SQVN 1924
Score = 73.2 bits (178), Expect = 3e-12
Identities = 129/612 (21%), Positives = 256/612 (41%), Gaps = 108/612 (17%)
Query: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE-QLTEGQIAANEALKKDLEGVISGLQ 622
+++ + + +L ++ +L E E EE Q + ++A +EA +K+LE + L
Sbjct: 828 MNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLL 887
Query: 623 EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
+ ++ Q Q E L D +E Q + Q +++ V AE+ + AEL +
Sbjct: 888 KEKNDLQ---LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 944
Query: 683 ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQLEQS 738
++ + + L++ DL A++E + + + L EE+ E + +LT+ E+
Sbjct: 945 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK-EKK 1003
Query: 739 ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
ALQ E +Q L + E+++ N+ AK+K L+QQ+ D + L
Sbjct: 1004 ALQ---EAHQQTLDD------LQAEEDKVNTLTKAKIK--------LEQQVDDLEGSLE- 1045
Query: 799 VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
+E R+D R K KL G++ + +S+ D++ E+
Sbjct: 1046 --------QEKKLRMDLERAKRKL-EGDLKLAQ------ESIMDIEN-----------EK 1079
Query: 859 DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI-- 916
+ + +K + E++ Q K+ E+AL ++ ++ +ARI+++E EI
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIED---------EQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 917 ----------------HYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK---- 956
L+E + +EE G T Q++ + + R+LE+
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 957 --------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
+KK D+ ++ EQ+ L + +KL+K + K+ +L + + G
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEMKMEIDDLASNVETVSKAKG 1249
Query: 1007 TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK--- 1063
+ K+ + ++L E + + + DLT ++ + GE R EK
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ------TESGEFSRQLDEKEAL 1303
Query: 1064 -TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFENVLEEIAEL 1119
+ + G + +IE+L +E + L + L + D + +E E AEL
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 1120 RREVSYQNDYIS 1131
+R +S N ++
Sbjct: 1364 QRALSKANTEVA 1375
Score = 48.9 bits (115), Expect = 6e-05
Identities = 73/363 (20%), Positives = 159/363 (43%), Gaps = 48/363 (13%)
Query: 270 EEVERLERD---LEKKMIET--EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEEL 324
EE+++L+R+ + + M T E++S+ + K + LN+ + + + E L
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 325 KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
++ NT+ +LK I L A + Q +L+++LA + A N +E E+ ++
Sbjct: 1647 RNYRNTQG-ILKDTQIHLDDALRSQEDLKEQLAMVERRA-----NLLQAEIEELRATLEQ 1700
Query: 385 SPYIGKSRYKRNMFATESYIIDSAQAVQI------KKMEPDEQLRNDHMNLRGHTP-LDT 437
+ +R+ E ++D+++ VQ+ + ++L D ++G +
Sbjct: 1701 T--------ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ 1752
Query: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEA------ 489
+ + E+K A T + + +E++K + K +E+ ++ ++ EA
Sbjct: 1753 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812
Query: 490 -GKDLLYK------QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQI 538
GK + K +L G ++ K EA+ + E++ +E+ + +K I LQ
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872
Query: 539 AIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
+D L +K + K Q E+Q + ++++L+ L+E R ++ L +
Sbjct: 1873 LVDKLQAKVKSY---KRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVK 1929
Query: 599 LTE 601
E
Sbjct: 1930 SRE 1932
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 157 bits (398), Expect = 9e-38
Identities = 219/1048 (20%), Positives = 447/1048 (42%), Gaps = 124/1048 (11%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
++++++ + + ++ + A KR+ E E EL +IDDL +E E V+
Sbjct: 923 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 982
Query: 1386 KRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEIECIE---KTLLKRRSEL-READR 1440
++ +D + L E +K+L+ H+ +D+++ E TL K + +L ++ D
Sbjct: 983 NLTEEMAGLDETIAKLTKE---KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 1441 LLA--EAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQ 1497
L E E +L E+ K +E A+ S++ E++ ++L+ + ++ + +
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Query: 1498 LRSLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1556
+ QA L Q KIK+ + ++E+ + + A+ + K++ L+ EL+++ + +E
Sbjct: 1100 IEDEQALGIQL-QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 1557 AERNEDHHLQVLKESEVLLQAKRAELEK----------------------LKSQVTSQQQ 1594
A +++ K+ E Q R +LE+ L Q+ + Q+
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 1595 EMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
L+++ K E+ L ++ +AK +L++ R E +++E + E + L+ +
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL------KNIL-DM 1704
L+ Q+G L + E QL + + + Q +Q+ + K +L KN L
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 1705 LQLENHELQGLKLQHD---------QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIE 1755
LQ H+ L+ Q++ QR T+VA K E + +Q+ + ++ + +
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398
Query: 1756 WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ-------EKCDIWEKKLAQTKR 1808
Q L+ + +E + A+ +L+ + L E EDL C +KK +
Sbjct: 1399 LA-QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 1809 VLAAAEENSKMEQSNLEKLELNVRKL-----------QQELDQLN---RDKLSLHNDISA 1854
+LA ++ + + LE + R L ++ LDQL R+ +L +IS
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 1855 MQQQLQEKREAVNSLQEELANVQD---HLNLAKQDLLHTTKHQD-VLLSEQTRLQKDISE 1910
+ +Q+ E + ++ L++ V+ L A ++ + +H++ +L Q L + SE
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
+ +K+EE Q ++ N +++V E M L E S + K
Sbjct: 1578 VDRKI--AEKDEEIDQ---------LKRNHIRIV--ESMQSTLDAEIRSRNDAIRLKK-- 1622
Query: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
++E +L + + +L+ A E +R + + + + L R +
Sbjct: 1623 ------KMEGDLNEMEIQLNHANR---MAAEALRNYRNTQGILKDTQIHLDDALRSQEDL 1673
Query: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKN 2090
++QL LQ E + +RA Q RK AE+++ E +++ +Q
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASERVQLLHTQNTSL 1729
Query: 2091 LLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQ 2150
+ +K+ + I + +E + Q+ + K + ELKK+ LER +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1789
Query: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT 2210
+ ++ L+ + + + +LK + + +L A R LEGE+ES ++
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA-------RVRELEGEVESEQKRNAEA 1842
Query: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQT 2270
+ +G + + ++ E R LR L+ D+L+A+++ +QAE + + Q+
Sbjct: 1843 V-KGLRKHERRVKELTYQTEEDRKNILR--LQDLVDKLQAKVK-SYKRQAE---EAEEQS 1895
Query: 2271 EGTLHSLRRQVDALGELVTSTSADSASS 2298
L R+ L E AD A S
Sbjct: 1896 NTNLAKFRKLQHELEE--AEERADIAES 1921
Score = 154 bits (390), Expect = 7e-37
Identities = 202/1027 (19%), Positives = 445/1027 (43%), Gaps = 126/1027 (12%)
Query: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
++ L+ E EK + + +E + I+ L K ++ +E + + E + + + +
Sbjct: 842 IKPLLKSAETEKEMA---TMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898
Query: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
E DA+ Q +LE + +E ++ L A + LE + ++
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958
Query: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN----EDHHLQVLKESEV 1573
+ ++ +A + + K + LTEE+ L + I + ++ H Q L +
Sbjct: 959 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD--- 1015
Query: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633
LQA+ ++ L +Q++ L+ L +K+ L+ + +AK L+ L+L +
Sbjct: 1016 -LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK----LRMDLERAKRKLEGDLKLAQE 1070
Query: 1634 EVTEKCNHIREVKSLLEELSFQKG--------------ELNVQISERKTQLTLIKQEIEK 1679
+ + N +++ L++ F+ +L +I E + ++ +++EIE
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 1680 EEENLQVVLRQMSKHKTELKNILDML---------QLE---NHELQGLKLQHDQRVSELE 1727
E + +Q S EL+ I + L Q+E E + K++ D + L+
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
A K +++ ++ +Q ++ KQ LE++K E M E L S VE +SK
Sbjct: 1191 HEATAATLRKKHADSVAELG-EQIDNLQRVKQKLEKEKSE---MKMEIDDLASNVETVSK 1246
Query: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ---SNLEKLELNVRKLQQELD----- 1839
K +L++ C E +L++ K + EE ++ + +L+ + ++LD
Sbjct: 1247 AKGNLEKMCRTLEDQLSELK---SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303
Query: 1840 --QLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
QL+R K + I +++QL+E+ +A N+L L + + +L ++ + + L
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 1898 LSEQTRLQKDISEWANRFED--CQKEEETKQ------QQLQVLQNEIEENKLKLVQQEMM 1949
++ ++++W ++E Q+ EE ++ Q+LQ + +E K E
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 1950 FQRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
QRLQ E E + + + L ++Q +K L + K K ++ +++ A+++ R+L
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 2007 -----------QEEERWCESLEKTLSQTKRQLSEREQQLVE---KSGELLALQKEADSMR 2052
+E E+L++ ++++S+ +Q+ E + EL ++K+ + +
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543
Query: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI---- 2108
+ + + E ++ ++ L +S++++ + E+ +E +++ I
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603
Query: 2109 ------ELVAQDNHERARRLMK-ELNQMQYEYTELKKQMA--------NQKDLERRQMEI 2153
E+ ++++ R ++ M+ +LN+M+ + + A Q L+ Q+ +
Sbjct: 1604 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL 1663
Query: 2154 SDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN----LEGELESLKE--NL 2207
DA+R+ + ++K+++ + N E+ +L A LE+ E E EL E L
Sbjct: 1664 DDALRS-QEDLKEQLAMVERRANLLQAEI-EELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 2208 PFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLK------AQLRHCMSKQAE 2261
T N K + I E + ++ R+ E++ K A + + K+ +
Sbjct: 1722 LHTQNTSLINTKKKL-ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780
Query: 2262 V---LIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTE-DSQLGQN 2317
L + K+ E T+ L+ ++D +L A + +LE+ + E + ++
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQL-----ALKGGKKQIQKLEARVRELEGEVESE 1835
Query: 2318 QEKNASA 2324
Q++NA A
Sbjct: 1836 QKRNAEA 1842
Score = 120 bits (301), Expect = 2e-26
Identities = 175/858 (20%), Positives = 359/858 (41%), Gaps = 142/858 (16%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRAS--KRQSE--KEMEELHHNIDDL-------LQE 1369
L+ ++ L+ ++ L+ + ER RA K++S+ +E+EE+ +++ ++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 1370 KKSLECEVEELHRTVQK------------RQQQKDFID------GNVESLMTELEIEKSL 1411
K E E +++ R +++ R++ D + N++ + +LE EKS
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
E +D++ +T+ K + L + R L + SEL +E+ + + T A+R L
Sbjct: 1230 MKME--IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT-AQRGRL 1286
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS 1531
QTES + +E V+ Q R QA + +E+ K + EE +K N + A S
Sbjct: 1287 QTESGEFSRQLDEKEALVS-----QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 1532 ---DFQCLSKKKEKLTEELQKLQKDI-----EMAERNEDHHLQVLKESEVLLQAKRAELE 1583
D L ++ E+ E +LQ+ + E+A+ + ++ +E L +AK+
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK---- 1397
Query: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1643
KL ++ + ++ + ++ + ++ LQ + D++ ++ N +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 1644 EVKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
+ ++ EL E + T+L IK E+ + L+ + R+ + E+ +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 1701 ILDMLQLEN---HELQGLKLQHDQRVSEL----EKTQVAVLEEKLELENLQQISQQQKGE 1753
+ + + HEL+ +K Q +Q EL E+ + ++ E+ ++ +Q Q K E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 1754 IEWQKQLLERDK----------REIERMT----AESRALQSCVECLSKEKEDLQEKCDIW 1799
++ +++ E+D+ R +E M AE R+ + K + DL E
Sbjct: 1578 VD--RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM---- 1631
Query: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
E +L R+ A A N + Q L+ +++ LD R + L ++ ++++
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIH-------LDDALRSQEDLKEQLAMVERRA 1684
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT-------RLQKDISEWA 1912
+ + L+ L + +A+Q+LL ++ +L ++ T +L+ DIS+
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE---ESKLETSKV 1969
ED LQ +N E+ K + MM + L+KE+++ E + +
Sbjct: 1745 GEMEDI----------LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1794
Query: 1970 TLKEQQ-------------------------HQLEKELTDQKSKLDQVLSKVLAAEERVR 2004
T+K+ Q +LE E+ ++ + + + + E RV+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854
Query: 2005 TLQ---EEER--------WCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
L EE+R + L+ + KRQ E E+Q + LQ E +
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914
Query: 2054 DFSLLRNQFLTERKKAEK 2071
+ +Q R K+ +
Sbjct: 1915 RADIAESQVNKLRVKSRE 1932
Score = 117 bits (292), Expect = 2e-25
Identities = 209/981 (21%), Positives = 397/981 (40%), Gaps = 169/981 (17%)
Query: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK--KMIETE-ELKSKQTRFLEEIKNQD 304
+ LE + VT + + E E L E+ ++I+T+ +L++K E ++++
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936
Query: 305 KLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAK 364
++N L + + C ELK D++ +ELT A + E E+ K+
Sbjct: 937 EINAELTAKKRKLEDECSELKKDID---------DLELTLA---KVEKEKHATENKVKNL 984
Query: 365 FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIK-------KME 417
E + A++ K K+ + +D QA + K K++
Sbjct: 985 TEEMAGLDETIAKLTKE------------KKALQEAHQQTLDDLQAEEDKVNTLTKAKIK 1032
Query: 418 PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
++Q+ + L+ LE ++K + +L +++ A++ I+ E +QL
Sbjct: 1033 LEQQVDD----------LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082
Query: 478 EEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ 537
+E +LKK K+ L +++ ++AL ++L QK+IK+LQ
Sbjct: 1083 DE--KLKK-----KEFEISNLQSKIE-----DEQALGIQL------------QKKIKELQ 1118
Query: 538 IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK---- 593
I+ L+ + +A ++ E+Q ++++ +++ RL+E + + E K
Sbjct: 1119 ARIEELEEEIEAE---RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 594 -------DLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
DLEE + + A KK + V + L E + ++ + + E +++ E
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEI 1234
Query: 647 ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
+ L + V + + LE + E+ +L+EL+S +EQ + L +G L
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLED---QLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Query: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFS----- 761
E +L+ ++A +QL + T+ Q+E+ L+ +LE+E +A KNAL A S
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQ--QIEE--LKRQLEEEIKA-KNALAHALQSSRHDC 1346
Query: 762 -------EEKEQENSELHAKL----------------------KHLQDDNNLLKQQLKDF 792
EE+++ +EL L + L++ L Q+L+
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 793 QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA 852
+ H+ V E+ R+ L L N +L Q+ F +ILA
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN------AACAALDKKQRNFDKILA 1460
Query: 853 RSKWERDEAQVRERKLQEE---MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARI 909
K + +E Q+E + + K+ EE E N + +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 910 QQME--NEIHYLQENLKSMEEIQGLTDLQLQEA----DEEKERILAQLRELEKKKKLEDA 963
Q E IH L++ K +E+ + L+EA + E+ +IL EL + K D
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 964 KSQEQVFGLDKELKKLK----KAVATSDKLATAELTIAKDQL---KSLHGTV--MKINQE 1014
K E+ D+E+ +LK + V + AE+ D + K + G + M+I
Sbjct: 1581 KIAEK----DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 1015 RAEEL-QEAERFSRK--------------AAQAARDLTRAEAEIELLQNLLRQKGEQFRL 1059
A + EA R R A ++ DL A +E NLL+ + E+ R
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 1060 EMEKTGVGTG-ANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAE 1118
+E+T A ++L+ + + + Q T + + L+ S +G E++L+E
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756
Query: 1119 LRREVSYQNDYISSMADPFKR 1139
+ + MA+ K+
Sbjct: 1757 AEEKAKKAITDAAMMAEELKK 1777
Score = 114 bits (284), Expect = 1e-24
Identities = 149/714 (20%), Positives = 314/714 (43%), Gaps = 106/714 (14%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWM------RASKRQSE-----KEMEELHHNIDDLLQ 1368
NLE LED + LKSK+ E++ + + + Q+E ++++E + L +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLM---------------TELEIEKSL-K 1412
K++ ++EEL R +++ + K+ + ++S ++ E++++L K
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 1413 HHEDIVDEIECIEKTLLKRRSELREADRLLAE----AE----------SELSCTKEKTKN 1458
+ ++ E ++R EL EA + LA+ AE + L TK++ +N
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 1459 AVEKF------TDAKRSLLQTESD-----AEELERRAQETAVNLVKADQQLRSLQADA-- 1505
VE T+A + L + E +++ +ET L + ++ RSL +
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 1506 -KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1564
K+ + + Q E LK NK + + SD + K EL+K++K +E E
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKCE 1545
Query: 1565 LQV-LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD 1623
LQ L+E+E L+ + ++ +++ ++ + E+ DR++ K EE+ L+ + ++
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHIRIVES 1602
Query: 1624 LQEALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKE 1680
+Q L + E+ + + IR K + L E+ Q N +E + ++
Sbjct: 1603 MQSTL---DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDT 1659
Query: 1681 EENLQVVLRQMSKHKTELKNI---LDMLQLENHELQGL--KLQHDQRVSELEKTQVAVLE 1735
+ +L LR K +L + ++LQ E EL+ + + ++++E E +
Sbjct: 1660 QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1719
Query: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS-----KEKE 1790
+ L +N I+ ++K E + + E + E AE +A ++ + K+++
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENS-----KMEQSNLEKLELNVRKLQQELDQLNRDK 1845
D + +K + QT + L + + K + ++KLE VR+L+ E++
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES----- 1834
Query: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
+ + EAV L++ V++ ++D + + QD++ +LQ
Sbjct: 1835 ------------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV----DKLQ 1878
Query: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ-KERE 1958
+ + + E+ +++ T + + LQ+E+EE + + E +L+ K RE
Sbjct: 1879 AKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 94.4 bits (233), Expect = 1e-18
Identities = 121/613 (19%), Positives = 248/613 (40%), Gaps = 87/613 (14%)
Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREE--RWMRASKRQSEKEMEELHHNIDDLLQEK 1370
C++ E + S+ E +Q SK E +W + + + EEL L Q
Sbjct: 1346 CDLLREQYEEEQESKAE--LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE--------IEKSLKHHEDIVDE-- 1420
++ E VE ++ ++ K + VE LM ++E ++K ++ + I+ E
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK 1463
Query: 1421 ---------IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
+E +K +EL + E+ +L K + KN ++ +D +
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 1472 QTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLE----QHKIKQEEILKEINKIVA 1527
+ ELE+ ++ + L +A + E + +++ ++ E+++ +A
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Query: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV-----LKESEVLLQ-AKRAE 1581
KD + L + ++ E +Q D E+ RN+ L+ L E E+ L A R
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 1582 LEKLKSQVTSQQ-------------QEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEAL 1628
E L++ +Q + L QL + +LLQ + + +A L++
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702
Query: 1629 R---LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
R + E E+ + ++ + + L K +L IS+ + ++ I QE EE +
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762
Query: 1686 VVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL-----EKTQVAVLEEKLEL 1740
+ + ELK D + L+ +K +Q V +L E Q+A+ K ++
Sbjct: 1763 KAITDAAMMAEELKKEQDT----SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818
Query: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
+ L+ ++ +GE+E +++ R+ ++ + R ++ ++++++ D+ +
Sbjct: 1819 QKLEARVRELEGEVESEQK---RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875
Query: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
K A+ K AEE + +NL K RKLQ EL +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKF----RKLQHEL---------------------E 1910
Query: 1861 EKREAVNSLQEEL 1873
E E + + ++
Sbjct: 1911 EAEERADIAESQV 1923
Score = 90.5 bits (223), Expect = 2e-17
Identities = 132/695 (18%), Positives = 298/695 (42%), Gaps = 44/695 (6%)
Query: 1644 EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD 1703
++K LL+ +K +++ K + IK E+ K E + + +M T LK D
Sbjct: 841 KIKPLLKSAETEK-----EMATMKEEFQKIKDELAKSEAKRKELEEKMV---TLLKEKND 892
Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLER 1763
+ E +GL ++R +L KT++ + + E+ + ++ E+ +K+ LE
Sbjct: 893 LQLQVQAEAEGLA-DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED 951
Query: 1764 DKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823
+ E+++ + + VE KEK + K +++A +A + K Q
Sbjct: 952 ECSELKKDIDDLELTLAKVE---KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 1824 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLA 1883
++ +++ + +++ L + K+ L + ++ L+++++ L+ ++ L LA
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
++ ++ + L + + + +IS ++ ED Q Q++++ LQ IEE + ++
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 1944 VQQEMMFQRLQKERESEESKLETSKVTLKE------QQHQLEKELTDQKSKLDQVLSK-V 1996
+ + +K+R +LE L+E Q ++ K+ + K+ + L +
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 1997 LAAEERVRTLQEEE--------RWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
L E TL+++ ++L++ + +++ SE + ++ + + + + K
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
++ L +Q L+E K E++ L L QR +L+ E + + + ++ A +
Sbjct: 1249 GNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQ---TESGEFSRQLDEKEALV 1304
Query: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
+++ +++ +EL + E + K +A+ R ++ + E K E+
Sbjct: 1305 SQLSRGKQAFTQQI-EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 2169 RTSLKNLNQFLPELPADLEA-ILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHI 2227
+ +L N + + E ++R E LE + L + L E +N +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH---VEAVNAKCASL 1420
Query: 2228 MDEHWRGEALREKLRHREDRLKAQLRHCMSKQA---EVLIKGKRQTEGT---LHSLRRQV 2281
R + E L +R A KQ ++L + K++ E T L + +++
Sbjct: 1421 EKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEA 1480
Query: 2282 DALGELVTSTSADSASSPSLSQLESSLTEDSQLGQ 2316
+LG + +A SL QLE+ E+ L Q
Sbjct: 1481 RSLGTELFKIK--NAYEESLDQLETLKRENKNLQQ 1513
Score = 89.0 bits (219), Expect = 5e-17
Identities = 161/724 (22%), Positives = 323/724 (44%), Gaps = 119/724 (16%)
Query: 245 RSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK-KMIETEELKSKQTRFLEEIKNQ 303
R + L Q Q F R L+E E L L + K T++++ + + EEIK +
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSR-QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332
Query: 304 DKLNKSL----------KEEAMLQKQSCEELKSDLNTKN-ELLKQKTIELTRACQKQYEL 352
+ L +L +E+ +++S EL+ L+ N E+ + +T T A Q+ EL
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 353 EQ---ELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID--- 406
E+ +LA ++ A E + ++ A ++K K R + + E ++D
Sbjct: 1393 EEAKKKLA-QRLQAAEEHVEAVNAKCASLEKT--------KQRLQNEV---EDLMLDVER 1440
Query: 407 --SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE 464
+A A KK +++ + T +LE +K+ + T L ++ + E++
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEET--HAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 465 QQILRATEEFKQLEEAIQ--LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQ 522
Q+ E K L++ I ++I+E GK + + ++ ++ QE +L+ +E+
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-----KIKKQVEQEKCELQAALEEA 1553
Query: 523 KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQY----QQLESRL 578
+ + ++ +I +Q+ ++ + S+ + + + K++++D + + + + ++S L
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSE------VDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607
Query: 579 D-EILSR-----IAKETE-EIKDLEEQLTEGQIAANEALK--KDLEGVISGLQEYLGTIK 629
D EI SR + K+ E ++ ++E QL A EAL+ ++ +G++ Q +L
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD--- 1664
Query: 630 GQATQAQNECRK---LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQE 686
A ++Q + ++ + + + LLQ E+E+ R LE + +EL + +Q
Sbjct: 1665 -DALRSQEDLKEQLAMVERRANLLQ--AEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 687 QHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEK 746
H N SL T+ L + + +Q++ E+E + Q A AE EK
Sbjct: 1722 LHTQNTSLINTKKKL--------------ETDISQMQGEMEDIL------QEARNAE-EK 1760
Query: 747 ERQALKNALGKAQFSEE--KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVD--- 801
++A+ +A A +EE KEQ+ S HL+ ++Q +KD Q L+
Sbjct: 1761 AKKAITDA---AMMAEELKKEQDTSA------HLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 802 --GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLG-KSLADLQKQFSEILARSKWER 858
G + +++ ARV EL GE+ + K L +++ E+ ++
Sbjct: 1812 KGGKKQIQKLEARVRELE-------GEVESEQKRNAEAVKGLRKHERRVKELT----YQT 1860
Query: 859 DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHY 918
+E + +LQ+ + Q K+ + + + +A E++ F K QHE + +I
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE 1920
Query: 919 LQEN 922
Q N
Sbjct: 1921 SQVN 1924
Score = 73.2 bits (178), Expect = 3e-12
Identities = 129/612 (21%), Positives = 256/612 (41%), Gaps = 108/612 (17%)
Query: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEE-QLTEGQIAANEALKKDLEGVISGLQ 622
+++ + + +L ++ +L E E EE Q + ++A +EA +K+LE + L
Sbjct: 828 MNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLL 887
Query: 623 EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
+ ++ Q Q E L D +E Q + Q +++ V AE+ + AEL +
Sbjct: 888 KEKNDLQ---LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 944
Query: 683 ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL----EKVTRLTQLEQS 738
++ + + L++ DL A++E + + + L EE+ E + +LT+ E+
Sbjct: 945 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK-EKK 1003
Query: 739 ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
ALQ E +Q L + E+++ N+ AK+K L+QQ+ D + L
Sbjct: 1004 ALQ---EAHQQTLDD------LQAEEDKVNTLTKAKIK--------LEQQVDDLEGSLE- 1045
Query: 799 VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWER 858
+E R+D R K KL G++ + +S+ D++ E+
Sbjct: 1046 --------QEKKLRMDLERAKRKL-EGDLKLAQ------ESIMDIEN-----------EK 1079
Query: 859 DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI-- 916
+ + +K + E++ Q K+ E+AL ++ ++ +ARI+++E EI
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIED---------EQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 917 ----------------HYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK---- 956
L+E + +EE G T Q++ + + R+LE+
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 957 --------KKKLEDAKSQ--EQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG 1006
+KK D+ ++ EQ+ L + +KL+K + K+ +L + + G
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEMKMEIDDLASNVETVSKAKG 1249
Query: 1007 TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEK--- 1063
+ K+ + ++L E + + + DLT ++ + GE R EK
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ------TESGEFSRQLDEKEAL 1303
Query: 1064 -TGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSD---NKGGFENVLEEIAEL 1119
+ + G + +IE+L +E + L + L + D + +E E AEL
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 1120 RREVSYQNDYIS 1131
+R +S N ++
Sbjct: 1364 QRALSKANTEVA 1375
Score = 48.9 bits (115), Expect = 6e-05
Identities = 73/363 (20%), Positives = 159/363 (43%), Gaps = 48/363 (13%)
Query: 270 EEVERLERD---LEKKMIET--EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEEL 324
EE+++L+R+ + + M T E++S+ + K + LN+ + + + E L
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 325 KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
++ NT+ +LK I L A + Q +L+++LA + A N +E E+ ++
Sbjct: 1647 RNYRNTQG-ILKDTQIHLDDALRSQEDLKEQLAMVERRA-----NLLQAEIEELRATLEQ 1700
Query: 385 SPYIGKSRYKRNMFATESYIIDSAQAVQI------KKMEPDEQLRNDHMNLRGHTP-LDT 437
+ +R+ E ++D+++ VQ+ + ++L D ++G +
Sbjct: 1701 T--------ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ 1752
Query: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEA------ 489
+ + E+K A T + + +E++K + K +E+ ++ ++ EA
Sbjct: 1753 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812
Query: 490 -GKDLLYK------QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQI 538
GK + K +L G ++ K EA+ + E++ +E+ + +K I LQ
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872
Query: 539 AIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQ 598
+D L +K + K Q E+Q + ++++L+ L+E R ++ L +
Sbjct: 1873 LVDKLQAKVKSY---KRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVK 1929
Query: 599 LTE 601
E
Sbjct: 1930 SRE 1932
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 157 bits (397), Expect = 1e-37
Identities = 232/1082 (21%), Positives = 468/1082 (43%), Gaps = 149/1082 (13%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEE--LHHNIDDLLQEKKSLECE- 1376
NLE EVS + +++ ++K + + M K QS +E +E + +D L Q K+ E
Sbjct: 295 NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAER 354
Query: 1377 --------VEELHRTVQKRQQQKDFIDGNVESLMTELEI-EKSL----KHHEDIVDEIEC 1423
EEL + QQ K + +E + E EI E++L K ++ + +
Sbjct: 355 QRNEALYNAEELSKAF---QQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGL 411
Query: 1424 IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERR 1483
+ L + +LR+ + +L K + + T++++S+L+ ES+ E +
Sbjct: 412 YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEI 471
Query: 1484 AQETAVNLVKADQQLR---SLQADAKDLEQHKIKQEEI-LKEINKIVAAKDSDFQCLSKK 1539
++ +L+ +++L+ + Q + DL Q +I+ + L+ + KI++ + K
Sbjct: 472 LRD-KFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFK 530
Query: 1540 ----KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
K +++ K + I E N+ V+ E + L K AE++KL + +T+ Q
Sbjct: 531 SYLSKYQMSSFSNKEDRCIGCCEANK----LVISELRIKLAIKEAEIQKLHANLTANQLS 586
Query: 1596 MAVL---DRQLGHKKEELHL----LQGSMVQAKADLQEALRLG---ETEVTEKCNHIREV 1645
+++ D Q K L L G V Q + E E I E+
Sbjct: 587 QSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEEL 646
Query: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
++ L ++ + +L V ++ R +Q LI++E+ ++ N + +M+K ++L + L
Sbjct: 647 RTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQL 706
Query: 1706 Q----------LENHELQGLKLQHDQRVSELEKTQVAVLEEK--LELENLQQISQQQKGE 1753
+ +N EL+ ++ ++++ LE T + EK L E ++I +Q E
Sbjct: 707 EEKIVAYSSIAAKNAELEQELMEKNEKIRSLE-TNINTEHEKICLAFEKAKKIHLEQHKE 765
Query: 1754 IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1813
+E ++IER+ A+ EK+D Q K + ++ ++
Sbjct: 766 ME----------KQIERLEAQ------------LEKKDQQFK---------EQEKTMSML 794
Query: 1814 EENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL 1873
+++ +Q +LE L+ R L + ++ ++ + + A+Q Q+ E+ V L
Sbjct: 795 QQDIICKQHHLESLD---RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA- 850
Query: 1874 ANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVL- 1932
L + K++L+ H + L + + +K + + + QKE + K LQ
Sbjct: 851 ------LEICKEELV---LHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETS 901
Query: 1933 -QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQ 1991
QN I ++ L+ QQ+ M Q + +LE ++ L++Q +LE+EL Q+ +
Sbjct: 902 EQNVILQHTLQ--QQQQMLQ----QETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE 955
Query: 1992 VLSKVLAAEERVRTLQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKE 2047
L K+ EE+ + E + L T Q K ++ + +++L + E++ L+++
Sbjct: 956 KLRKM---EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 1012
Query: 2048 ADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMAT 2107
++ S L + + EK+ ++KE K+Q S E L E Q+ ++ E+
Sbjct: 1013 GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHS-TETELTEALQKREVLETEL-- 1069
Query: 2108 IELVAQDNHERARRLMKELNQ----MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSE 2163
Q+ H + +++L + +Q L+++ KDL E + K E
Sbjct: 1070 -----QNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQE 1124
Query: 2164 VKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFS 2223
+ E+ +LK N L + A + + GE+E L T+ + E K
Sbjct: 1125 LL-EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK 1183
Query: 2224 QVHIMDEHWRG--EALREK----LRHRED--RLKAQLRHCMS--KQAEVLIKGKRQTEGT 2273
Q+ +++ + E LREK L++ ++ +LK ++ K+ E ++K + Q T
Sbjct: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243
Query: 2274 -----------LHSLRRQV-DALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
L R QV ++ EL + + + +L S L + QL + ++ +
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAH 1303
Query: 2322 AS 2323
+
Sbjct: 1304 GN 1305
Score = 155 bits (392), Expect = 4e-37
Identities = 200/1080 (18%), Positives = 461/1080 (42%), Gaps = 130/1080 (12%)
Query: 1330 DIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQ 1389
D+++ K KR ER + +E+ + + ++ + ++ E E L R + ++
Sbjct: 341 DLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK 400
Query: 1390 QKDFIDGNVESLMTELEIEKS----LKH---------------HEDIVDEIECIEKTLLK 1430
+ + +ELEI K LK + +++ ++ +++LK
Sbjct: 401 ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK 460
Query: 1431 RRSELREADRLLAEAESELSCTKE-KTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
SEL D +L + S ++ +E K + A + + + L Q E ++ +E R+ E +
Sbjct: 461 LESELENKDEILRDKFSLMNENRELKVRVAAQ---NERLDLCQQEIESSRVELRSLEKII 517
Query: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEE------------ILKEINKIVAAKDSDFQCL- 1536
+ + ++L ++ + +E ++ E+ +A K+++ Q L
Sbjct: 518 SQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLH 577
Query: 1537 --------------------SKKKEKLTEELQKLQKDIEMAERNEDHHLQVL-KESEVLL 1575
S K L E KL ++AE +D + + K+ E
Sbjct: 578 ANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGH-QVAESVKDQNQHTMNKQYEKER 636
Query: 1576 QAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEV 1635
Q +E+L++++ + E + L + H+ + L+Q +++ ++ + E+E+
Sbjct: 637 QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL----ESEM 692
Query: 1636 TEKCNHIREVKSLLEE-------LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVL 1688
T+KC+ + ++ LEE ++ + EL ++ E+ ++ ++ I E E + +
Sbjct: 693 TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF 752
Query: 1689 RQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKT----QVAVLEEKLELENLQ 1744
+ K E ++ Q+E E Q K DQ+ E EKT Q ++ ++ LE+L
Sbjct: 753 EKAKKIHLEQHKEMEK-QIERLEAQLEK--KDQQFKEQEKTMSMLQQDIICKQHHLESLD 809
Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESR--------ALQSCVECLSKEKEDLQEKC 1796
++ + KGE++ + + + ++ +E AL+ C E L L+
Sbjct: 810 RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
Query: 1797 DIWEKKLAQTKRVLAAAEENSKMEQSNLEKL-ELNV---RKLQQELDQLNRDKL------ 1846
+ +EK+L + + ++ K++ +L++ E NV LQQ+ L ++ +
Sbjct: 870 EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELE 929
Query: 1847 ----SLHNDISAMQQQLQEKREA----VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
L +S ++Q+LQ++RE+ + ++E+ + +L +Q ++ T +
Sbjct: 930 DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVK 989
Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
E + ++++S+ +++ E K L L +++ K +L ++ + L+K +
Sbjct: 990 IEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH 1049
Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEK 2018
S E++L + + + +L+ + KS L Q+ ++ +L+E+ + L
Sbjct: 1050 STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109
Query: 2019 TLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASL-- 2076
L + K ++ +++Q+L+E L E A + L R + E+++ L
Sbjct: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
Query: 2077 ---KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY 2133
K L+++ + L K +N+ ++++ E + N + +L KE+ + Q
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNA--KEQLREKEFIMLQNEQEISQLKKEIERTQQRM 1227
Query: 2134 TELKKQMANQKDLERRQ----MEISDAMRTLKSEVKD------EIRTSLKNLNQFLPELP 2183
E++ M Q+ Q +++ +R + +V++ E R + + L
Sbjct: 1228 KEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLS 1287
Query: 2184 ADLEAILERNENLEGELESLKENLPFT-MNEGPFEEKLN------FSQVHIMDEHWRGEA 2236
++LE + + ++ + L E L + + E E ++ ++V + E + E
Sbjct: 1288 SELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEM 1347
Query: 2237 LREKLRHREDRLKAQLRHCMSKQA-EVLIKGK---RQTEGTLHSLRRQVDALGELVTSTS 2292
+ + H + ++ A + +Q E L K K + + T+ +L +QV E++ + +
Sbjct: 1348 ISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAAN 1407
Score = 141 bits (356), Expect = 7e-33
Identities = 235/1185 (19%), Positives = 501/1185 (42%), Gaps = 176/1185 (14%)
Query: 1299 PNFSIPFIPMGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRAS---KRQSEKE 1355
P S+P +G + + +++N +NE L + L+ + + W S + S
Sbjct: 107 PGGSLPSDDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP 166
Query: 1356 MEELHHNIDDLLQEKKSLE-----------------CEVEELHRTVQKRQQQKDF----- 1393
E + + EK L+ C++ QK+ + K F
Sbjct: 167 SENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAP 226
Query: 1394 IDGNVESLMTELEIEKS-----LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESE 1448
+D ++SL +L + + + ++ + E I L + R+++ + +A S
Sbjct: 227 VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS- 285
Query: 1449 LSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDL 1508
+ +E+ N + + + L + E+ E+ ++ E +L ++ ++ L+ D L
Sbjct: 286 VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDL--L 343
Query: 1509 EQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVL 1568
EQ K + + ++ N+ + + + + K+K+ E+L+K+Q + E+ ERN + +
Sbjct: 344 EQTK-QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
Query: 1569 KESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS--MVQAKADLQE 1626
K + ++ELE LK ++ ++E G +K + ++ S M Q Q
Sbjct: 403 KRLQERCGLYKSELEILKEKLRQLKEE-----NNNGKEKLRIMAVKNSEVMAQLTESRQS 457
Query: 1627 ALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQV 1686
L+L E+E+ K +R+ SL+ E EL V+++ + +L L +QEIE L+
Sbjct: 458 ILKL-ESELENKDEILRDKFSLMNE----NRELKVRVAAQNERLDLCQQEIESSRVELRS 512
Query: 1687 VLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL----EN 1742
+ + +S+ + + L +++ + D+ + E ++ + E +++L
Sbjct: 513 LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 572
Query: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMTA----------------------------- 1773
+Q++ Q + D +E ++++
Sbjct: 573 IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY 632
Query: 1774 --ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNV 1831
E + L + +E L + ++ + + +A +E + SN KLE +
Sbjct: 633 EKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEM 692
Query: 1832 RKLQQELDQLNR---DKLSLHNDISA----MQQQLQEKREAVNSLQEELANVQDHLNLA- 1883
K +L L + +K+ ++ I+A ++Q+L EK E + SL+ + + + LA
Sbjct: 693 TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF 752
Query: 1884 -KQDLLHTTKH----------------QDVLLSEQTR----LQKDISEWANRFE------ 1916
K +H +H +D EQ + LQ+DI + E
Sbjct: 753 EKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL 812
Query: 1917 -----DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE-------RESEESKL 1964
+ +KE K + L+ LQN++ E +K+ Q + + ++E E + K
Sbjct: 813 TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKF 872
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVL----AAEERVRTLQEEERWCESLEKTL 2020
E E+ + L+KEL + L + + + +++ + LQ+E LE T
Sbjct: 873 EKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQ 932
Query: 2021 SQTKRQLSEREQQLV---EKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
++ ++Q+S+ EQ+L E S E L +E A + L+ Q + E +QV
Sbjct: 933 TKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEM 992
Query: 2078 EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNH---ERARRLMKELNQMQY--- 2131
+ K + S++EK ++ K++ ++ ++++ E+ +KEL ++Q+
Sbjct: 993 DQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE 1052
Query: 2132 -EYTE-LKKQMANQKDLERRQMEISDAMRTLKSEVKDEIR----------TSLKNLNQFL 2179
E TE L+K+ + +L+ E+ +R L+ E++D ++ T++K+L L
Sbjct: 1053 TELTEALQKREVLETELQNAHGELKSTLRQLQ-ELRDVLQKAQLSLEEKYTTIKDLTAEL 1111
Query: 2180 PELPADLE----AILERNENLEGELESLKE------NLPFTMNE--GPFEEK-------L 2220
E ++E +LE ++ L+ LK+ +L T+ E G E+K L
Sbjct: 1112 RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTL 1171
Query: 2221 NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
S++ + + + + E+L +KL++ +++L+ + M + + + + K++ E T ++
Sbjct: 1172 EKSELELKECNKQIESLNDKLQNAKEQLR-EKEFIMLQNEQEISQLKKEIERTQQRMKEM 1230
Query: 2281 VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
+ E + + L Q E LT + Q+ + + A AR
Sbjct: 1231 ESVMKEQEQYIATQYKEAIDLGQ-ELRLTRE-QVQNSHTELAEAR 1273
Score = 117 bits (293), Expect = 1e-25
Identities = 179/844 (21%), Positives = 360/844 (42%), Gaps = 129/844 (15%)
Query: 266 RFSLEEVERLERDLEKKMIE-TEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEEL 324
R L ++E DL+ M T + + Q LE+ N KL + ++
Sbjct: 647 RTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC---------- 696
Query: 325 KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDE 384
S L T + L++K + + K ELEQEL + N +E+ +I A ++
Sbjct: 697 -SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNIN-TEHEKICLAFEK 754
Query: 385 SPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK 444
+ I ++K QI+++E + + D Q +++EK
Sbjct: 755 AKKIHLEQHKE-------------MEKQIERLEAQLEKK------------DQQFKEQEK 789
Query: 445 KISAAQTRLSELHDEIEKAEQQILRATEEFKQ----LEEAIQLKKISEAGKDLLYKQLSG 500
+S Q + +E ++ + + E K+ +EA++ + + + + +QL
Sbjct: 790 TMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDS 849
Query: 501 RLQL--------VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSH 552
L++ +N+L E Q++K+ +E+ QKE+K ++ ++ H
Sbjct: 850 ALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQH 909
Query: 553 MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE--------TEEIKDLEEQLTEGQI 604
Q+ QQ I N + + +++L++ +S++ +E E+++ +EE+ +
Sbjct: 910 TLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKC---ES 966
Query: 605 AANEA-LKK----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE 659
AA+EA LK+ +L G ++ + K + ++ + E L+ + E L++++
Sbjct: 967 AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026
Query: 660 RDQLEIVAMDAENMRKEL--------AELESALQEQHEVNASLQQTQGDLSAYEAELEAR 711
DQ + N KEL EL ALQ++ + LQ G+L + +L+
Sbjct: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQEL 1086
Query: 712 LNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSEL 771
++ L+E+ + LT E + E+E ++Q L L Q +E+ E +
Sbjct: 1087 RDVLQKAQLSLEEKYTTIKDLT-AELRECKMEIEDKKQEL---LEMDQALKERNWELKQR 1142
Query: 772 HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHS 831
A++ HL + H + +++ E + +L+L I S
Sbjct: 1143 AAQVTHLD----------MTIREHRGEMEQKIIKLEGTLE-----KSELELKECNKQIES 1187
Query: 832 PSDVLGKSLADLQK------QFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE 885
+D L + L++ Q + +++ K E + Q R ++++ M Q++ +AT +
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT---Q 1244
Query: 886 FRQACERALEARMNFDKRQH------EARIQQM--ENEIHYLQENLKSMEEIQGLTDLQL 937
+++A + E R+ ++ Q+ EAR QQ+ + EI L L+ M+++
Sbjct: 1245 YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS------- 1297
Query: 938 QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAV---ATSDKLATAEL 994
+E D + +L + ++ +A+ Q ++ L E++ LK+A S + A+
Sbjct: 1298 KEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKW 1357
Query: 995 TIAKDQLKSLHGTVMKINQ--ERAE-ELQEAERFSRKAAQAARDLTRAEAEIELLQNLLR 1051
I+ D KS +V ++N+ E+A+ EL+EA+ Q +D IE L
Sbjct: 1358 KISADSQKS---SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEV---IEAANEALL 1411
Query: 1052 QKGE 1055
KGE
Sbjct: 1412 TKGE 1415
Score = 114 bits (284), Expect = 1e-24
Identities = 209/1019 (20%), Positives = 419/1019 (41%), Gaps = 192/1019 (18%)
Query: 258 QDRQEAFERFSLEEVERLERDLEKKM----IETEELKSKQTRFLEEIKN-QDKL------ 306
Q +E ER +L E+ + L+++ E E LK K + EE N ++KL
Sbjct: 385 QAEEEILER-NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVK 443
Query: 307 NKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE 366
N + + +QS +L+S+L K+E+L+ K + ++ ++ ++D +
Sbjct: 444 NSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNE--NRELKVRVAAQNERLDLCQQ 501
Query: 367 PLNYYPSEYAEIDKAPDESPYIGK--------SRYKRNMFAT-ESYIIDSAQA------- 410
+ E ++K + P + S+Y+ + F+ E I +A
Sbjct: 502 EIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE 561
Query: 411 VQIKKMEPDEQLRNDHMNLRGH-------TPLDTQLEDKEKKISAAQTRLS--------- 454
++IK + +++ H NL + T D+Q K + +L
Sbjct: 562 LRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVK 621
Query: 455 -----ELHDEIEKAEQQILRATEEFK----QLEEAIQLKKISEAGK----DLLYKQLSGR 501
++ + EK Q+++ EE + Q+E K++ A + L+ ++L +
Sbjct: 622 DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
Query: 502 LQLVNKLRQE-------ALDLELQMEKQ--------------KQEIAGKQKEIKDLQIAI 540
+KL E L LE Q+E++ +QE+ K ++I+ L+ I
Sbjct: 682 ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNI 741
Query: 541 DSLDSKD------------PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
++ K +H M+ Q E QL+ ++Q+++ E + + I +
Sbjct: 742 NTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801
Query: 589 TEEIKDLEEQLTEGQ-IAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE-- 645
++ L+ LTE + E +KKD E L ++ Q ++ + R+L
Sbjct: 802 QHHLESLDRLLTESKGEMKKENMKKD---------EALKALQNQVSEETIKVRQLDSALE 852
Query: 646 --KETLLQRLTEVEQERD----QLEIVAMDAENMRKELAELESALQEQHEVNASLQQT-- 697
KE L+ L ++E ++ QL+ + + ++KEL +LQE E N LQ T
Sbjct: 853 ICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ 912
Query: 698 ------------QGDLSAYEAELEARLNLRDAEANQLKE-ELEKVTRLTQLEQSALQAEL 744
G+L + +LE +++ + E + +E EK+ ++ + +SA E
Sbjct: 913 QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH-EA 971
Query: 745 EKERQALKNALGKAQ----FSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVV 800
+ +RQ + G A+ ++ ++E S++ ++ HL+ D L L+
Sbjct: 972 DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK 1031
Query: 801 DGLVRPEEVAARVDELRRKLK------------LGTGEMNIHSP-----------SDVLG 837
L + +++L+ + L T N H DVL
Sbjct: 1032 TELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQ 1091
Query: 838 KSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQE-KLATGQEEFRQACERALEA 896
K+ L+++++ I + R+ E K QE + + Q K + + R A L+
Sbjct: 1092 KAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDM 1151
Query: 897 RMNFDKRQHEARIQQMENEIHYLQENLKSM-EEIQGLTDLQLQEADE---EKERILAQLR 952
+ + + E +I ++E + + LK ++I+ L D +LQ A E EKE I+ Q
Sbjct: 1152 TIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND-KLQNAKEQLREKEFIMLQNE 1210
Query: 953 ELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT---AELTIAKDQLKSLHGTVM 1009
+ + K E ++Q+++ ++ +K+ ++ +AT K A EL + ++Q+++ H +
Sbjct: 1211 QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELA 1270
Query: 1010 KINQERAEELQEAERFSRK----------------------AAQAARDL---TRAEAEIE 1044
+ ++ + +E ER S + A R+ R +AEI+
Sbjct: 1271 EARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIK 1330
Query: 1045 LLQNLLRQKGEQFRLEM-----EKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVL 1098
L + E + +EM A+SQ +++LNE +E+ + E+ Q+ +
Sbjct: 1331 KLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTV 1389
Score = 108 bits (270), Expect = 6e-23
Identities = 126/589 (21%), Positives = 283/589 (48%), Gaps = 78/589 (13%)
Query: 1329 EDIMQHLKSKK-REERWMRASKRQSE------KEMEELHHNIDDLLQEKKSLECEVEELH 1381
E+++ HL + +E++ + K++SE KE++ +H++ + ++ L+ +++
Sbjct: 856 EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ- 914
Query: 1382 RTVQKRQQQKDFIDGNVESLMTELE-----IEKSL-KHHEDIVDEIECIEKTLLKRRSEL 1435
Q+ QQ+ +G +E T+LE +E+ L K E +++ +E+ K S
Sbjct: 915 ---QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE---KCESAA 968
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
EAD L + EL+ T + K ++++ K L + E + L+R + A++L + D
Sbjct: 969 HEAD-LKRQKVIELTGTARQVKIEMDQY---KEELSKMEKEIMHLKRDGENKAMHLSQLD 1024
Query: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
L + + + K+ +KE+ K+ + +++ +K+E L ELQ +++
Sbjct: 1025 MILDQTKTELE-------KKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK 1077
Query: 1556 MAERNEDHHLQVLKESEVLLQAK-------RAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
R VL+++++ L+ K AEL + K ++ ++QE+ +D+ L +
Sbjct: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137
Query: 1609 EL--------HL------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSF 1654
EL HL +G M Q L+ L E E+ E CN ++++SL ++L
Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE-CN--KQIESLNDKLQN 1194
Query: 1655 QKGELNVQ---ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK----TELKNILDM--- 1704
K +L + + + + +++ +K+EIE+ ++ ++ + M + + T+ K +D+
Sbjct: 1195 AKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254
Query: 1705 LQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERD 1764
L+L ++Q + + + + Q + ELE+++Q+S+++ + L
Sbjct: 1255 LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314
Query: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNL 1824
K + E+R +Q+ ++ LS E E L+E + ++ + A + ++ ++S++
Sbjct: 1315 K--VREAHLEAR-MQAEIKKLSAEVESLKEA---YHMEMISHQENHAKWKISADSQKSSV 1368
Query: 1825 EKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL 1873
++L + K + EL++ + +S + QQ+Q++ E + + E L
Sbjct: 1369 QQLNEQLEKAKLELEE-------AQDTVSNLHQQVQDRNEVIEAANEAL 1410
Score = 73.2 bits (178), Expect = 3e-12
Identities = 72/368 (19%), Positives = 172/368 (46%), Gaps = 26/368 (7%)
Query: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQ 1385
+ L++ LKS R+ + +R ++++ +EE + I DL E + + E+E+ + +
Sbjct: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELL 1126
Query: 1386 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHE-DIVDEIECIEKTLLKRRSELREADRLLA 1443
+ Q + ++ ++ ++ +++ H ++ +I +E TL K EL+E ++ +
Sbjct: 1127 EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIE 1186
Query: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 1503
+L KE+ + ++ + Q + + E ++R +E + + +Q + +
Sbjct: 1187 SLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYK 1246
Query: 1504 DAKDLEQH-KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
+A DL Q ++ +E++ ++ A+ Q ++ E+L+ EL+ +++ + + + +
Sbjct: 1247 EAIDLGQELRLTREQVQNSHTELAEARHQQVQA-QREIERLSSELEDMKQLSKEKDAHGN 1305
Query: 1563 H---HLQVLKESEVLLQAK-RAELEKLKSQVTSQQQ--EMAVLDRQLGHKKEELHLLQGS 1616
H L K E L+A+ +AE++KL ++V S ++ M ++ Q H K ++
Sbjct: 1306 HLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKI------ 1359
Query: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
AD Q ++ V + + + K LEE L+ Q+ +R + +
Sbjct: 1360 ----SADSQ------KSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
Query: 1677 IEKEEENL 1684
+ + EN+
Sbjct: 1410 LLTKGENV 1417
Score = 64.7 bits (156), Expect = 1e-09
Identities = 134/701 (19%), Positives = 288/701 (41%), Gaps = 101/701 (14%)
Query: 520 EKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLD 579
+K A +EIK L+ + L+ +++ + Q + + ++ + Q +++
Sbjct: 218 DKMFSSSAPVDQEIKSLR---EKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVS 274
Query: 580 EILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
+L ++ + LEEQ+ E +++A + + ++ E + Q+ + + +++
Sbjct: 275 -MLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
Query: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE-VNASLQQ 696
EC KL K LL++ + ++ Q +AE + K + + + E+ E V A +
Sbjct: 334 ECIKL---KVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI 390
Query: 697 TQGDLSAYEAE---LEARLNLRDAEANQLKEELEKV----------TRLTQLEQSALQAE 743
+ +L+ E E L+ R L +E LKE+L ++ R+ ++ S + A+
Sbjct: 391 LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450
Query: 744 LEKERQALKNALGKAQFSEE-------KEQENSELHAKLKHLQDDNNLLKQQLKDFQ--- 793
L + RQ++ + + +E EN EL ++ + +L +Q+++ +
Sbjct: 451 LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL 510
Query: 794 NHLNHVVDGLVRPEEVAARVDEL----------RRKLKLGTGEMNIHSPSDV---LGKSL 840
L ++ L E+ L + +G E N S++ L
Sbjct: 511 RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE 570
Query: 841 ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
A++QK + + A + ++ + +L+ E + G + ++ + + MN
Sbjct: 571 AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMN- 629
Query: 901 DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEK---- 956
+Q+E Q++ I L+ L +E +DL++ A + L Q LEK
Sbjct: 630 --KQYEKERQRLVTGIEELRTKLIQIEAEN--SDLKVNMAHRTSQFQLIQEELLEKASNS 685
Query: 957 -KKKLEDAKSQEQVFGLDKELKK---LKKAVATSDKLATAELTIAKDQLKSLHGTV---- 1008
K + E K Q+ L+K+L++ ++A + EL ++++SL +
Sbjct: 686 SKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEH 745
Query: 1009 ----------MKINQERAEELQ-EAERFSRKAAQAARDLTRAEAEIELLQN--------- 1048
KI+ E+ +E++ + ER + + + E + +LQ
Sbjct: 746 EKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHL 805
Query: 1049 ------LLRQKGEQFRLEMEKTGVGTGANSQV----LEIEKLNETMERQRTEIARLQNVL 1098
L KGE + M+K +QV +++ +L+ +E + E+ N L
Sbjct: 806 ESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL 865
Query: 1099 DLTGSDNKGGFENVL----EEIAELRREVSYQNDYISSMAD 1135
+ NK FE L EE+ L++E+ +N + ++
Sbjct: 866 E----GNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 902
Score = 48.9 bits (115), Expect = 6e-05
Identities = 81/388 (20%), Positives = 160/388 (41%), Gaps = 45/388 (11%)
Query: 764 KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKL- 822
K+ E L A + L+ + + + L+ L+ V P E + R KL
Sbjct: 129 KDNEEESLLANVASLRHELKITEWSLQSLGEELSSV-----SPSENSDYAPNPSRSEKLI 183
Query: 823 ------GTGEMNIHSPSDVLGK---SLADLQKQFSEILARSKWERDEAQVRERKLQEEMA 873
G +N +SP + + K S D QK+ + + S D+ R+ ++
Sbjct: 184 LDVQPSHPGLLN-YSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLR 242
Query: 874 LQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN------EIHYLQENLKSME 927
Q L T E ++F+ Q A++ +E+ + L+E + ++E
Sbjct: 243 QQNACLVTQNHSLMTKFES-----IHFELTQSRAKVSMLESAQQQAASVPILEEQIINLE 297
Query: 928 EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
D L+EA+ + E+ +Q +EK++ L+++K E+ L +L + K ++
Sbjct: 298 AEVSAQDKVLREAENKLEQ--SQKMVIEKEQSLQESK--EECIKLKVDLLEQTKQGKRAE 353
Query: 988 KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE------- 1040
+ L A++ K+ K+ ++ + E E R ++ R +
Sbjct: 354 RQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYK 413
Query: 1041 AEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDL 1100
+E+E+L+ LRQ E+ EK + NS+V+ + R I +L++ L+
Sbjct: 414 SELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVM------AQLTESRQSILKLESELEN 467
Query: 1101 TGSDNKGGFENVLEEIAELRREVSYQND 1128
+ F +++ E EL+ V+ QN+
Sbjct: 468 KDEILRDKF-SLMNENRELKVRVAAQNE 494
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 157 bits (396), Expect = 1e-37
Identities = 223/1044 (21%), Positives = 430/1044 (41%), Gaps = 144/1044 (13%)
Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE--------- 1374
+V+R ++++Q ++ +E + ++ ++QS +E+ EL + L +E+ L
Sbjct: 871 QVTRQDEVLQ---ARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 927
Query: 1375 -CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
E EE + R+Q+ + + E+E + E+ +++ +K L +
Sbjct: 928 CAEAEETRGRLAARKQELELVVS---------ELEARVGEEEECSRQMQTEKKRLQQHIQ 978
Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
EL A +L K T+ ++KF + LL E +L + + L +
Sbjct: 979 ELEAHLEAEEGARQKLQLEKVTTEAKMKKF---EEDLLLLEDQNSKLSKERKLLEDRLAE 1035
Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
Q + K L + ++K E A +D + +K+EK +EL+KL++
Sbjct: 1036 FSSQAAEEEEKVKSLNKLRLKYE-----------ATIADMEDRLRKEEKGRQELEKLKRR 1084
Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL- 1612
++ E +L+ Q+ QQQ L QLG K+EEL
Sbjct: 1085 LD------------------------GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA 1120
Query: 1613 -------------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
L S+ +A+A L EA E+E + ++ + L EEL +GEL
Sbjct: 1121 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1180
Query: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQ 1718
+ Q QE+ + E + TELK L + ++ +Q L+ +
Sbjct: 1181 EDTLDSTNAQ-----QELRSKRE----------QEVTELKKTLEEETRIHEAAVQELRQR 1225
Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
H Q + EL +Q+ Q ++G+ W+K L + E+ + AE +L
Sbjct: 1226 HGQALGEL----------------AEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1268
Query: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
Q+ + + + L+ + + + +R A A E + Q+ LE + + + + +
Sbjct: 1269 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328
Query: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
+L+++ S + Q+ LQE+ A +L + ++ ++ L ++
Sbjct: 1329 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAG 1388
Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
E Q +SEW R E+ E ++ + E E +L ++ RL++ R
Sbjct: 1389 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1448
Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCE 2014
+ +L+ + + L EQQ QL L ++ K DQ+L++ AA +R ++E ER E
Sbjct: 1449 RLQQELDDATMDL-EQQRQLVSTLEKKQRKFDQLLAEEKAAV--LRAVEERERAEAEGRE 1505
Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
+ LS T+ E EQ+ E+ L+++ ++RA+ L L+ + K V
Sbjct: 1506 REARALSLTR--ALEEEQEAREE------LERQNRALRAELEAL----LSSKDDVGKSVH 1553
Query: 2075 SLKEALKIQR---SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQ 2128
L+ A ++ + L + E + E + + +E+ Q HER + E +
Sbjct: 1554 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1613
Query: 2129 MQYEYTELKKQMAN---QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
+ +L KQ+ + ++D ER+Q ++ A R +E++ + + Q E
Sbjct: 1614 ERRR--QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1671
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKL 2241
L + + + L E+E + + ++ EK L + + +E + R +
Sbjct: 1672 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1731
Query: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
+ D + ++ + +A +L + KRQ EG L L +++ E S + L
Sbjct: 1732 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEE--EQSNSELLNDRYRKLL 1788
Query: 2302 SQLESSLTEDSQLGQNQEKNASAR 2325
Q+ES TE S K S R
Sbjct: 1789 LQVESLTTELSAERSFSAKAESGR 1812
Score = 145 bits (367), Expect = 3e-34
Identities = 220/1036 (21%), Positives = 441/1036 (42%), Gaps = 139/1036 (13%)
Query: 1368 QEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIE 1422
++ + L+ +EL + VQ+ QQQ G ++ + +LE E++ L+ ++ E E
Sbjct: 874 RQDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 932
Query: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
L R+ EL + +++E E+ + +E ++ + ++ + + E+ E E
Sbjct: 933 ETRGRLAARKQEL---ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 989
Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
Q+ + V + +++ + D LE K L + K++ + ++F + ++E+
Sbjct: 990 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK----LSKERKLLEDRLAEFSSQAAEEEE 1045
Query: 1543 LTEELQKLQ-------KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
+ L KL+ D+E R E+ Q L++ + L + +EL++ Q+ QQQ
Sbjct: 1046 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQR 1102
Query: 1596 MAVLDRQLGHKKEELHL--------------LQGSMVQAKADLQEALRLGETEVTEKCNH 1641
L QLG K+EEL L S+ +A+A L EA E+E +
Sbjct: 1103 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1162
Query: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
++ + L EEL +GEL + Q QE+ + E + TELK
Sbjct: 1163 EKQRRDLGEELEALRGELEDTLDSTNAQ-----QELRSKRE----------QEVTELKKT 1207
Query: 1702 LDM-LQLENHELQGLKLQHDQRVSEL--------------EKTQVA----VLEEKLELEN 1742
L+ ++ +Q L+ +H Q + EL EKT++A V E + EL +
Sbjct: 1208 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1267
Query: 1743 LQ---QISQQQKGEIEWQKQ------------------LLERDKREIERMTAESRALQSC 1781
LQ Q +Q++ +E Q Q L+R + E+E ++ +S
Sbjct: 1268 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1327
Query: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
LSKE + + ++ L + R A + ++ L + + ++
Sbjct: 1328 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1387
Query: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
R+ + +S +++ +E+ A+ + +E Q L T+ D L +
Sbjct: 1388 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1447
Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
RLQ+++ + E ++ T +++ + + E K +++ +R + E E
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507
Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV-RTLQEEERWCESLEKTL 2020
++ + L+E+Q + +EL Q L L +L++++ V +++ E ER C E+
Sbjct: 1508 ARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA 1566
Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRA----DFSLLRNQFLTERKKAEKQVASL 2076
+ + Q++E E +L L L+ +++ D R++ KQ+
Sbjct: 1567 NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA 1626
Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
+ +R Q + +K+ +++ A + Q E ++L K QM+ + E+
Sbjct: 1627 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1686
Query: 2137 KKQMANQKDLERRQMEISDAMRTLKSEV---KDEIRTS---LKNLNQFLPELPADL---- 2186
++ +++++ + E ++ L++EV ++E+ S + Q E+ ++
Sbjct: 1687 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1746
Query: 2187 ---EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRH 2243
AILE LEG L L+E L EE+ + S+ ++++ +R KL
Sbjct: 1747 LSKAAILEEKRQLEGRLGQLEEEL---------EEEQSNSE--LLNDRYR------KLLL 1789
Query: 2244 REDRLKAQL--RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
+ + L +L S +AE G++Q E + LR + LGE A + ++
Sbjct: 1790 QVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGR---LGE--EDAGARARHKMTI 1841
Query: 2302 SQLESSLTE-DSQLGQ 2316
+ LES L + + QL Q
Sbjct: 1842 AALESKLAQAEEQLEQ 1857
Score = 116 bits (290), Expect = 3e-25
Identities = 203/951 (21%), Positives = 386/951 (40%), Gaps = 131/951 (13%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
++ L E LED + S+ EE S + + E +++D L++++ E
Sbjct: 1018 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1077
Query: 1377 VEELHRTVQ----KRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
+E+L R + + Q+Q E L +L E++ +L ED
Sbjct: 1078 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA----RAQ 1133
Query: 1428 LLKRRSELREADRLLAEAESELSCTK------EKTKNAVEKFTDAKRSLLQTESDA---- 1477
LLK LREA LAEA+ +L + EK + + + +A R L+ D+
Sbjct: 1134 LLK---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1190
Query: 1478 EELERRAQETAVNLVKA-DQQLRSLQADAKDLEQHKIKQ----EEILKEINKIVAAKDSD 1532
+EL + ++ L K +++ R +A ++L Q + E L++ + A +
Sbjct: 1191 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1250
Query: 1533 FQCLSKKKEKLTEELQKLQ---KDIEMAERNEDHHLQVLK-----------ESEVLLQAK 1578
L + +L EL LQ ++ E R + LQ ++ E+ LQ
Sbjct: 1251 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1310
Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEV 1635
+AELE + + + + L ++L + +LH Q + +AK L +R E E
Sbjct: 1311 QAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEA 1370
Query: 1636 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ---MS 1692
+ E + E + Q+SE + + +E EE + R+ ++
Sbjct: 1371 AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALT 1430
Query: 1693 KHKTELKNILDMLQLENHELQG------LKL-QHDQRVSELEKTQ----VAVLEEKLELE 1741
+ E +D L+ LQ + L Q Q VS LEK Q + EEK +
Sbjct: 1431 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV- 1489
Query: 1742 NLQQISQQQKGEIEWQKQ---------LLERDKREIERMTAESRALQSCVECLSKEKED- 1791
L+ + ++++ E E +++ LE ++ E + ++RAL++ +E L K+D
Sbjct: 1490 -LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1548
Query: 1792 ------LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR--KLQQELDQLNR 1843
L+ C + E+ + + E+ + +LE+ V+ K Q E D R
Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608
Query: 1844 DKLS------LHNDISAMQQQLQEKRE-------AVNSLQEELANVQDHLNLAKQDLLHT 1890
D+ L + + + E+R+ A L+ EL ++ + A Q
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668
Query: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
K + ++ L +++ E E+ + +++L+ L+ E+ + +L +
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728
Query: 1951 QRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSK-----------V 1996
++ Q++R+ E + SK + E++ QLE L + +L++ S +
Sbjct: 1729 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1788
Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK------EADS 2050
L E L E + E Q +RQ+ E +L E+ A K E+
Sbjct: 1789 LQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKL 1848
Query: 2051 MRADFSL---LRNQFLTER--KKAEKQ----VASLKEALKIQ---RSQLEKNLLEQKQEN 2098
+A+ L R + L+ + ++AEK+ V ++E ++ R QLEK L KQ
Sbjct: 1849 AQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ-- 1906
Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
+++++ E A RRL +EL + + +++ ++ RR
Sbjct: 1907 --LKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955
Score = 113 bits (282), Expect = 2e-24
Identities = 176/868 (20%), Positives = 361/868 (41%), Gaps = 136/868 (15%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL------QEKKSL 1373
+L + L + + L+S++ +R +E+E L ++D L QE +S
Sbjct: 1137 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1196
Query: 1374 -ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKR 1431
E EV EL +T+++ E+ + E +++ + H + E+ E +E+ +R
Sbjct: 1197 REQEVTELKKTLEE------------ETRIHEAAVQELRQRHGQALGELAEQLEQA--RR 1242
Query: 1432 RSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
E RL EAE +ELS + + ++ + L + + A + ER E
Sbjct: 1243 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1302
Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIK--------------QEEILKEINKIVAAKDSD 1532
A L +A +L ++ + E I+ +E+L+E + A S
Sbjct: 1303 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1362
Query: 1533 FQCLSKK--------------KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
+ + + +E+ ELQ Q + R ++ L+ E +
Sbjct: 1363 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1422
Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
E E L ++ + + + L+R G ++ LQ + A DL++ +L T ++
Sbjct: 1423 AREAEALTQRLAEKTETVDRLER--GRRR-----LQQELDDATMDLEQQRQLVSTLEKKQ 1475
Query: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
+ E K+ + ++ + ER+ + + + +E+E+E + + RQ +
Sbjct: 1476 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1535
Query: 1696 TELKNIL---DMLQLENHELQGLKLQHDQ-------RVSELEKTQVAVLEEKLELE-NLQ 1744
EL+ +L D + HEL+ +Q +V+ELE A + KL LE +Q
Sbjct: 1536 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1595
Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK-- 1802
+ Q + +++ + + E +R++ + ++ + +++E Q + +K
Sbjct: 1596 ALKTQHERDLQGRDEAGEERRRQLAKQLRDAE--------VERDEERKQRTLAVAARKKL 1647
Query: 1803 ---LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
L + K +A+A + + L K++ +++L +E+++ + + + +++L
Sbjct: 1648 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1707
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDISEWA 1912
+ V LQEELA A+QD + + + +L E+ +L+ + +
Sbjct: 1708 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1767
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
E+ Q E + + L ++E +L + + + R+ E +++ + L
Sbjct: 1768 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1827
Query: 1973 EQ------QHQ-----LEKELTDQKSKLDQ-----VLSKVLA--AEERVRTL----QEEE 2010
E+ +H+ LE +L + +L+Q +LS L AE+R++ + +EE
Sbjct: 1828 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1887
Query: 2011 RWCESLEKTLS-------QTKRQLSEREQQLVEKSGELLALQKE-------ADSMRADFS 2056
R + L L Q KRQL E E++ LQ+E A+SM + +
Sbjct: 1888 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1947
Query: 2057 LLRNQF----LTERKKAEKQVASLKEAL 2080
LRN+ LT + +QV L+E +
Sbjct: 1948 TLRNRLRRGPLTFTTRTVRQVFRLEEGV 1975
Score = 107 bits (267), Expect = 1e-22
Identities = 198/959 (20%), Positives = 406/959 (42%), Gaps = 110/959 (11%)
Query: 255 VTTQDRQEAFERFSLEEVERLERDLEKKMIETE----ELKSKQTRFLEEIKNQDKLNKSL 310
VT QD L++V+ L++ +++ E + +L+ ++ R E+++ + +L
Sbjct: 872 VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 931
Query: 311 KE---EAMLQKQSCE----ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
+E +KQ E EL++ + + E +Q E R Q ELE L +
Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 991
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
+ L +E A++ K ++ + K + + D + E +E+++
Sbjct: 992 QKLQLEKVTTE-AKMKKFEEDLLLLEDQNSK--LSKERKLLEDRLAEFSSQAAEEEEKVK 1048
Query: 424 NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
+ + + +ED+ +K + L +L ++ ++ E +Q E ++
Sbjct: 1049 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108
Query: 484 ---KKISEAGKDLLYKQLSG--RLQLVNKLRQ-EALDLELQMEKQKQEIAGK--QKEIKD 535
+K E L + G R QL+ LR+ +A E Q + + + +A +K+ +D
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1168
Query: 536 LQIAIDSL-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL----ESRLDEILSRIA 586
L +++L D+ D ++ + +S +EQ++ + K ++ E+ + E+ R
Sbjct: 1169 LGEELEALRGELEDTLDSTNAQQEL-RSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 587 KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
+ E+ + EQ G+ A E + LE +S L+ L +++ + + R+L +
Sbjct: 1228 QALGELAEQLEQARRGK-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1286
Query: 647 ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
+ + R + E+ R A AE +++ AELE+ +E + + +LS+ EA
Sbjct: 1287 QEVQGRAGDGERAR------AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1340
Query: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA-----LGKAQFS 761
+L L E + K L R + E + L+ +LE+E A + A +AQ S
Sbjct: 1341 QLHDAQELLQEET-RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1399
Query: 762 EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
E + ++ E A L+ ++ ++ + + L E R++ RR+L+
Sbjct: 1400 EWRRRQEEEAGA----LEAGEEARRRAAREAEA----LTQRLAEKTETVDRLERGRRRLQ 1451
Query: 822 --LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---------ERDEAQVRERKLQ- 869
L M++ ++ +L Q++F ++LA K ER EA+ RER+ +
Sbjct: 1452 QELDDATMDLEQQRQLVS-TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1510
Query: 870 -------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE---------------- 906
EE +E+L R E L ++ + K HE
Sbjct: 1511 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1570
Query: 907 ARIQQMENEIHYLQENLKSME------EIQGLTDLQ-LQEADEEKERILA-QLRELE--- 955
A++ ++E+E+ ++ +E + Q DLQ EA EE+ R LA QLR+ E
Sbjct: 1571 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1630
Query: 956 ---KKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
+K++ +++++ G +ELK + + A +L + Q+K L V +
Sbjct: 1631 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1690
Query: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-EKTGVGTGAN 1071
R E + ++ ++ R + E+ + R++ +Q R EM ++ G +
Sbjct: 1691 TSREEIFSQNRESEKRLKGLEAEVLRLQEEL-AASDRARRQAQQDRDEMADEVANGNLSK 1749
Query: 1072 SQVLEIEK-LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
+ +LE ++ L + + E+ Q+ +L + +L ++ L E+S + +
Sbjct: 1750 AAILEEKRQLEGRLGQLEEELEEEQSNSELLND----RYRKLLLQVESLTTELSAERSF 1804
Score = 82.8 bits (203), Expect = 4e-15
Identities = 180/860 (20%), Positives = 350/860 (40%), Gaps = 133/860 (15%)
Query: 247 LESLEGQPVTTQDRQEAFERFSL---EEVERLERDLEKKM----IETEELKSKQTRFLEE 299
LE+L G+ T D A + +EV L++ LE++ +EL+ + + L E
Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1232
Query: 300 IKNQ---DKLNKSLKEEAMLQKQS-CEELKSDLNTKNELLKQKTIELTRACQKQYELEQE 355
+ Q + K E+ L ++ EL+++L++ + +Q+ + R + Q + Q
Sbjct: 1233 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL-QTARQEGEQRRRRLELQLQEVQG 1291
Query: 356 LAFYKIDAKFEPLNYYPSEYAEIDKAPD-----ESPYIGKSRYKRNMFATESYIIDSAQA 410
A A+ E AE++ ES I R + + +TE+ + D+ +
Sbjct: 1292 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI---RLSKELSSTEAQLHDAQEL 1348
Query: 411 VQIK---KMEPDEQLRNDHMNLRGHTPLDTQLEDKE-------KKISAAQTRLSELHDE- 459
+Q + K+ ++R G L QLE++ +++ AQ +LSE
Sbjct: 1349 LQEETRAKLALGSRVRAMEAEAAG---LREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1405
Query: 460 ------IEKAEQQILRATEEFKQLEEAIQLKKIS----EAGKDLLYKQLSG-------RL 502
+E E+ RA E + L + + K + E G+ L ++L +
Sbjct: 1406 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1465
Query: 503 QLVNKLR------------QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
QLV+ L ++A L E+++ E G+++E + L + +L+ +
Sbjct: 1466 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT-RALEEEQEAR 1524
Query: 551 SHMKAQKSGKEQQLDIMNKQYQQLESRLDEI--LSRIAKETE-----EIKDLEEQLTEGQ 603
++ Q +L+ + + + E+ R+A++ ++ +LE++LT +
Sbjct: 1525 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1584
Query: 604 IA------ANEALK----KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
A +ALK +DL+G +E + Q A+ E + R ++ +
Sbjct: 1585 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1644
Query: 654 TEVEQERDQLEIVAMDA----ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
++E E ++L+ A E K+L ++++ ++E + ++ ++ + E E
Sbjct: 1645 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1704
Query: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ--- 766
RL +AE +L+EEL R + A Q E + L KA EEK Q
Sbjct: 1705 KRLKGLEAEVLRLQEELAASDR---ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1761
Query: 767 ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
+L +L+ Q ++ LL + + + + L +A+ + R++
Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ------- 1814
Query: 827 MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
L++Q E+ R E A+ R + +A + KLA +E+
Sbjct: 1815 ----------------LERQIQELRGRLGEEDAGARARHKM---TIAALESKLAQAEEQL 1855
Query: 887 RQAC-ERALEARM--NFDKRQHEARIQQMENE--IHYLQENLKSMEEIQGLTDLQLQEAD 941
Q ER L ++ +KR E +Q E L++ L+ QL+EA+
Sbjct: 1856 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1915
Query: 942 EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
EE R A R L+ ++LED E +++E+ L+ ++L LT +
Sbjct: 1916 EEASRAQAGRRRLQ--RELEDV--TESAESMNREVTTLR------NRLRRGPLTFTTRTV 1965
Query: 1002 KSLHGTVMKI-NQERAEELQ 1020
+ + + + E AEE Q
Sbjct: 1966 RQVFRLEEGVASDEEAEEAQ 1985
Score = 77.8 bits (190), Expect = 1e-13
Identities = 121/654 (18%), Positives = 273/654 (41%), Gaps = 69/654 (10%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD--LLQEKKSLECEVE 1378
L + ++L D + L+ + R + + + R E E L +++ +E+ E +
Sbjct: 1335 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1394
Query: 1379 ELHRTVQKRQQQKD---FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
+ + +R+Q+++ G E E + + + ++ +E+ + + EL
Sbjct: 1395 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1454
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET---AVNLV 1492
+A L + +S ++K + + + K ++L+ + E E +E A++L
Sbjct: 1455 DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1514
Query: 1493 KA-----------DQQLRSLQADAKDLEQHKIKQEEILKEINKIV-----AAKDSDFQCL 1536
+A ++Q R+L+A+ + L K + + E+ + AA D Q
Sbjct: 1515 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1574
Query: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE- 1595
+ E E KL+ ++ + H + E + +R ++L+ + +E
Sbjct: 1575 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1634
Query: 1596 ----MAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
+AV R+ L + EEL S Q K + + LR + ++ E + E ++ E
Sbjct: 1635 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1694
Query: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN-------ILD 1703
E+ Q E ++ + ++ +++E+ + + + + E+ N IL+
Sbjct: 1695 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1754
Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK-----LELENLQ-QISQQQK--GEIE 1755
E +L+G Q ++ + E E++ +L ++ L++E+L ++S ++ + E
Sbjct: 1755 ----EKRQLEGRLGQLEEELEE-EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1809
Query: 1756 WQKQLLERDKREIERMTAESRA---------LQSCVECLSKEKEDLQEKCD--IWEKKLA 1804
+Q LER +E+ E A + + L++ +E L+++ I KL
Sbjct: 1810 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1869
Query: 1805 QT-----KRVLAAAEENSKME---QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
+ K V+ EE ++ + LEK L V++L+++L++ + +Q
Sbjct: 1870 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1929
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
++L++ E+ S+ E+ +++ L T Q L E ++ E
Sbjct: 1930 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1983
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 157 bits (396), Expect = 1e-37
Identities = 223/1044 (21%), Positives = 430/1044 (41%), Gaps = 144/1044 (13%)
Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE--------- 1374
+V+R ++++Q ++ +E + ++ ++QS +E+ EL + L +E+ L
Sbjct: 863 QVTRQDEVLQ---ARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 919
Query: 1375 -CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
E EE + R+Q+ + + E+E + E+ +++ +K L +
Sbjct: 920 CAEAEETRGRLAARKQELELVVS---------ELEARVGEEEECSRQMQTEKKRLQQHIQ 970
Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
EL A +L K T+ ++KF + LL E +L + + L +
Sbjct: 971 ELEAHLEAEEGARQKLQLEKVTTEAKMKKF---EEDLLLLEDQNSKLSKERKLLEDRLAE 1027
Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
Q + K L + ++K E A +D + +K+EK +EL+KL++
Sbjct: 1028 FSSQAAEEEEKVKSLNKLRLKYE-----------ATIADMEDRLRKEEKGRQELEKLKRR 1076
Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL- 1612
++ E +L+ Q+ QQQ L QLG K+EEL
Sbjct: 1077 LD------------------------GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA 1112
Query: 1613 -------------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
L S+ +A+A L EA E+E + ++ + L EEL +GEL
Sbjct: 1113 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1172
Query: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQ 1718
+ Q QE+ + E + TELK L + ++ +Q L+ +
Sbjct: 1173 EDTLDSTNAQ-----QELRSKRE----------QEVTELKKTLEEETRIHEAAVQELRQR 1217
Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
H Q + EL +Q+ Q ++G+ W+K L + E+ + AE +L
Sbjct: 1218 HGQALGEL----------------AEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1260
Query: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
Q+ + + + L+ + + + +R A A E + Q+ LE + + + + +
Sbjct: 1261 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320
Query: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
+L+++ S + Q+ LQE+ A +L + ++ ++ L ++
Sbjct: 1321 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAG 1380
Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
E Q +SEW R E+ E ++ + E E +L ++ RL++ R
Sbjct: 1381 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1440
Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCE 2014
+ +L+ + + L EQQ QL L ++ K DQ+L++ AA +R ++E ER E
Sbjct: 1441 RLQQELDDATMDL-EQQRQLVSTLEKKQRKFDQLLAEEKAAV--LRAVEERERAEAEGRE 1497
Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
+ LS T+ E EQ+ E+ L+++ ++RA+ L L+ + K V
Sbjct: 1498 REARALSLTR--ALEEEQEAREE------LERQNRALRAELEAL----LSSKDDVGKSVH 1545
Query: 2075 SLKEALKIQR---SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQ 2128
L+ A ++ + L + E + E + + +E+ Q HER + E +
Sbjct: 1546 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1605
Query: 2129 MQYEYTELKKQMAN---QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
+ +L KQ+ + ++D ER+Q ++ A R +E++ + + Q E
Sbjct: 1606 ERRR--QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1663
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKL 2241
L + + + L E+E + + ++ EK L + + +E + R +
Sbjct: 1664 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1723
Query: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
+ D + ++ + +A +L + KRQ EG L L +++ E S + L
Sbjct: 1724 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEE--EQSNSELLNDRYRKLL 1780
Query: 2302 SQLESSLTEDSQLGQNQEKNASAR 2325
Q+ES TE S K S R
Sbjct: 1781 LQVESLTTELSAERSFSAKAESGR 1804
Score = 145 bits (367), Expect = 3e-34
Identities = 220/1036 (21%), Positives = 441/1036 (42%), Gaps = 139/1036 (13%)
Query: 1368 QEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIE 1422
++ + L+ +EL + VQ+ QQQ G ++ + +LE E++ L+ ++ E E
Sbjct: 866 RQDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 924
Query: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
L R+ EL + +++E E+ + +E ++ + ++ + + E+ E E
Sbjct: 925 ETRGRLAARKQEL---ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 981
Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
Q+ + V + +++ + D LE K L + K++ + ++F + ++E+
Sbjct: 982 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK----LSKERKLLEDRLAEFSSQAAEEEE 1037
Query: 1543 LTEELQKLQ-------KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
+ L KL+ D+E R E+ Q L++ + L + +EL++ Q+ QQQ
Sbjct: 1038 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQR 1094
Query: 1596 MAVLDRQLGHKKEELHL--------------LQGSMVQAKADLQEALRLGETEVTEKCNH 1641
L QLG K+EEL L S+ +A+A L EA E+E +
Sbjct: 1095 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1154
Query: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
++ + L EEL +GEL + Q QE+ + E + TELK
Sbjct: 1155 EKQRRDLGEELEALRGELEDTLDSTNAQ-----QELRSKRE----------QEVTELKKT 1199
Query: 1702 LDM-LQLENHELQGLKLQHDQRVSEL--------------EKTQVA----VLEEKLELEN 1742
L+ ++ +Q L+ +H Q + EL EKT++A V E + EL +
Sbjct: 1200 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1259
Query: 1743 LQ---QISQQQKGEIEWQKQ------------------LLERDKREIERMTAESRALQSC 1781
LQ Q +Q++ +E Q Q L+R + E+E ++ +S
Sbjct: 1260 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1319
Query: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
LSKE + + ++ L + R A + ++ L + + ++
Sbjct: 1320 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1379
Query: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
R+ + +S +++ +E+ A+ + +E Q L T+ D L +
Sbjct: 1380 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1439
Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
RLQ+++ + E ++ T +++ + + E K +++ +R + E E
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499
Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV-RTLQEEERWCESLEKTL 2020
++ + L+E+Q + +EL Q L L +L++++ V +++ E ER C E+
Sbjct: 1500 ARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA 1558
Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRA----DFSLLRNQFLTERKKAEKQVASL 2076
+ + Q++E E +L L L+ +++ D R++ KQ+
Sbjct: 1559 NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA 1618
Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
+ +R Q + +K+ +++ A + Q E ++L K QM+ + E+
Sbjct: 1619 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1678
Query: 2137 KKQMANQKDLERRQMEISDAMRTLKSEV---KDEIRTS---LKNLNQFLPELPADL---- 2186
++ +++++ + E ++ L++EV ++E+ S + Q E+ ++
Sbjct: 1679 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1738
Query: 2187 ---EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRH 2243
AILE LEG L L+E L EE+ + S+ ++++ +R KL
Sbjct: 1739 LSKAAILEEKRQLEGRLGQLEEEL---------EEEQSNSE--LLNDRYR------KLLL 1781
Query: 2244 REDRLKAQL--RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
+ + L +L S +AE G++Q E + LR + LGE A + ++
Sbjct: 1782 QVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGR---LGE--EDAGARARHKMTI 1833
Query: 2302 SQLESSLTE-DSQLGQ 2316
+ LES L + + QL Q
Sbjct: 1834 AALESKLAQAEEQLEQ 1849
Score = 116 bits (290), Expect = 3e-25
Identities = 203/951 (21%), Positives = 386/951 (40%), Gaps = 131/951 (13%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
++ L E LED + S+ EE S + + E +++D L++++ E
Sbjct: 1010 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1069
Query: 1377 VEELHRTVQ----KRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
+E+L R + + Q+Q E L +L E++ +L ED
Sbjct: 1070 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA----RAQ 1125
Query: 1428 LLKRRSELREADRLLAEAESELSCTK------EKTKNAVEKFTDAKRSLLQTESDA---- 1477
LLK LREA LAEA+ +L + EK + + + +A R L+ D+
Sbjct: 1126 LLK---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1182
Query: 1478 EELERRAQETAVNLVKA-DQQLRSLQADAKDLEQHKIKQ----EEILKEINKIVAAKDSD 1532
+EL + ++ L K +++ R +A ++L Q + E L++ + A +
Sbjct: 1183 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1242
Query: 1533 FQCLSKKKEKLTEELQKLQ---KDIEMAERNEDHHLQVLK-----------ESEVLLQAK 1578
L + +L EL LQ ++ E R + LQ ++ E+ LQ
Sbjct: 1243 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1302
Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEV 1635
+AELE + + + + L ++L + +LH Q + +AK L +R E E
Sbjct: 1303 QAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEA 1362
Query: 1636 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ---MS 1692
+ E + E + Q+SE + + +E EE + R+ ++
Sbjct: 1363 AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALT 1422
Query: 1693 KHKTELKNILDMLQLENHELQG------LKL-QHDQRVSELEKTQ----VAVLEEKLELE 1741
+ E +D L+ LQ + L Q Q VS LEK Q + EEK +
Sbjct: 1423 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV- 1481
Query: 1742 NLQQISQQQKGEIEWQKQ---------LLERDKREIERMTAESRALQSCVECLSKEKED- 1791
L+ + ++++ E E +++ LE ++ E + ++RAL++ +E L K+D
Sbjct: 1482 -LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1540
Query: 1792 ------LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR--KLQQELDQLNR 1843
L+ C + E+ + + E+ + +LE+ V+ K Q E D R
Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600
Query: 1844 DKLS------LHNDISAMQQQLQEKRE-------AVNSLQEELANVQDHLNLAKQDLLHT 1890
D+ L + + + E+R+ A L+ EL ++ + A Q
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660
Query: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
K + ++ L +++ E E+ + +++L+ L+ E+ + +L +
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720
Query: 1951 QRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSK-----------V 1996
++ Q++R+ E + SK + E++ QLE L + +L++ S +
Sbjct: 1721 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1780
Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK------EADS 2050
L E L E + E Q +RQ+ E +L E+ A K E+
Sbjct: 1781 LQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKL 1840
Query: 2051 MRADFSL---LRNQFLTER--KKAEKQ----VASLKEALKIQ---RSQLEKNLLEQKQEN 2098
+A+ L R + L+ + ++AEK+ V ++E ++ R QLEK L KQ
Sbjct: 1841 AQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ-- 1898
Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
+++++ E A RRL +EL + + +++ ++ RR
Sbjct: 1899 --LKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947
Score = 113 bits (282), Expect = 2e-24
Identities = 176/868 (20%), Positives = 361/868 (41%), Gaps = 136/868 (15%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL------QEKKSL 1373
+L + L + + L+S++ +R +E+E L ++D L QE +S
Sbjct: 1129 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1188
Query: 1374 -ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKR 1431
E EV EL +T+++ E+ + E +++ + H + E+ E +E+ +R
Sbjct: 1189 REQEVTELKKTLEE------------ETRIHEAAVQELRQRHGQALGELAEQLEQA--RR 1234
Query: 1432 RSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
E RL EAE +ELS + + ++ + L + + A + ER E
Sbjct: 1235 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1294
Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIK--------------QEEILKEINKIVAAKDSD 1532
A L +A +L ++ + E I+ +E+L+E + A S
Sbjct: 1295 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1354
Query: 1533 FQCLSKK--------------KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
+ + + +E+ ELQ Q + R ++ L+ E +
Sbjct: 1355 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1414
Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
E E L ++ + + + L+R G ++ LQ + A DL++ +L T ++
Sbjct: 1415 AREAEALTQRLAEKTETVDRLER--GRRR-----LQQELDDATMDLEQQRQLVSTLEKKQ 1467
Query: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
+ E K+ + ++ + ER+ + + + +E+E+E + + RQ +
Sbjct: 1468 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1527
Query: 1696 TELKNIL---DMLQLENHELQGLKLQHDQ-------RVSELEKTQVAVLEEKLELE-NLQ 1744
EL+ +L D + HEL+ +Q +V+ELE A + KL LE +Q
Sbjct: 1528 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1587
Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK-- 1802
+ Q + +++ + + E +R++ + ++ + +++E Q + +K
Sbjct: 1588 ALKTQHERDLQGRDEAGEERRRQLAKQLRDAE--------VERDEERKQRTLAVAARKKL 1639
Query: 1803 ---LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
L + K +A+A + + L K++ +++L +E+++ + + + +++L
Sbjct: 1640 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1699
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDISEWA 1912
+ V LQEELA A+QD + + + +L E+ +L+ + +
Sbjct: 1700 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1759
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
E+ Q E + + L ++E +L + + + R+ E +++ + L
Sbjct: 1760 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1819
Query: 1973 EQ------QHQ-----LEKELTDQKSKLDQ-----VLSKVLA--AEERVRTL----QEEE 2010
E+ +H+ LE +L + +L+Q +LS L AE+R++ + +EE
Sbjct: 1820 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1879
Query: 2011 RWCESLEKTLS-------QTKRQLSEREQQLVEKSGELLALQKE-------ADSMRADFS 2056
R + L L Q KRQL E E++ LQ+E A+SM + +
Sbjct: 1880 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1939
Query: 2057 LLRNQF----LTERKKAEKQVASLKEAL 2080
LRN+ LT + +QV L+E +
Sbjct: 1940 TLRNRLRRGPLTFTTRTVRQVFRLEEGV 1967
Score = 107 bits (267), Expect = 1e-22
Identities = 198/959 (20%), Positives = 406/959 (42%), Gaps = 110/959 (11%)
Query: 255 VTTQDRQEAFERFSLEEVERLERDLEKKMIETE----ELKSKQTRFLEEIKNQDKLNKSL 310
VT QD L++V+ L++ +++ E + +L+ ++ R E+++ + +L
Sbjct: 864 VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 923
Query: 311 KE---EAMLQKQSCE----ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
+E +KQ E EL++ + + E +Q E R Q ELE L +
Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 983
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
+ L +E A++ K ++ + K + + D + E +E+++
Sbjct: 984 QKLQLEKVTTE-AKMKKFEEDLLLLEDQNSK--LSKERKLLEDRLAEFSSQAAEEEEKVK 1040
Query: 424 NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
+ + + +ED+ +K + L +L ++ ++ E +Q E ++
Sbjct: 1041 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100
Query: 484 ---KKISEAGKDLLYKQLSG--RLQLVNKLRQ-EALDLELQMEKQKQEIAGK--QKEIKD 535
+K E L + G R QL+ LR+ +A E Q + + + +A +K+ +D
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1160
Query: 536 LQIAIDSL-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL----ESRLDEILSRIA 586
L +++L D+ D ++ + +S +EQ++ + K ++ E+ + E+ R
Sbjct: 1161 LGEELEALRGELEDTLDSTNAQQEL-RSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 587 KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
+ E+ + EQ G+ A E + LE +S L+ L +++ + + R+L +
Sbjct: 1220 QALGELAEQLEQARRGK-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1278
Query: 647 ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
+ + R + E+ R A AE +++ AELE+ +E + + +LS+ EA
Sbjct: 1279 QEVQGRAGDGERAR------AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1332
Query: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA-----LGKAQFS 761
+L L E + K L R + E + L+ +LE+E A + A +AQ S
Sbjct: 1333 QLHDAQELLQEET-RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1391
Query: 762 EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
E + ++ E A L+ ++ ++ + + L E R++ RR+L+
Sbjct: 1392 EWRRRQEEEAGA----LEAGEEARRRAAREAEA----LTQRLAEKTETVDRLERGRRRLQ 1443
Query: 822 --LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---------ERDEAQVRERKLQ- 869
L M++ ++ +L Q++F ++LA K ER EA+ RER+ +
Sbjct: 1444 QELDDATMDLEQQRQLVS-TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1502
Query: 870 -------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE---------------- 906
EE +E+L R E L ++ + K HE
Sbjct: 1503 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1562
Query: 907 ARIQQMENEIHYLQENLKSME------EIQGLTDLQ-LQEADEEKERILA-QLRELE--- 955
A++ ++E+E+ ++ +E + Q DLQ EA EE+ R LA QLR+ E
Sbjct: 1563 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1622
Query: 956 ---KKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
+K++ +++++ G +ELK + + A +L + Q+K L V +
Sbjct: 1623 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1682
Query: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-EKTGVGTGAN 1071
R E + ++ ++ R + E+ + R++ +Q R EM ++ G +
Sbjct: 1683 TSREEIFSQNRESEKRLKGLEAEVLRLQEEL-AASDRARRQAQQDRDEMADEVANGNLSK 1741
Query: 1072 SQVLEIEK-LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
+ +LE ++ L + + E+ Q+ +L + +L ++ L E+S + +
Sbjct: 1742 AAILEEKRQLEGRLGQLEEELEEEQSNSELLND----RYRKLLLQVESLTTELSAERSF 1796
Score = 82.8 bits (203), Expect = 4e-15
Identities = 180/860 (20%), Positives = 350/860 (40%), Gaps = 133/860 (15%)
Query: 247 LESLEGQPVTTQDRQEAFERFSL---EEVERLERDLEKKM----IETEELKSKQTRFLEE 299
LE+L G+ T D A + +EV L++ LE++ +EL+ + + L E
Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1224
Query: 300 IKNQ---DKLNKSLKEEAMLQKQS-CEELKSDLNTKNELLKQKTIELTRACQKQYELEQE 355
+ Q + K E+ L ++ EL+++L++ + +Q+ + R + Q + Q
Sbjct: 1225 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL-QTARQEGEQRRRRLELQLQEVQG 1283
Query: 356 LAFYKIDAKFEPLNYYPSEYAEIDKAPD-----ESPYIGKSRYKRNMFATESYIIDSAQA 410
A A+ E AE++ ES I R + + +TE+ + D+ +
Sbjct: 1284 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI---RLSKELSSTEAQLHDAQEL 1340
Query: 411 VQIK---KMEPDEQLRNDHMNLRGHTPLDTQLEDKE-------KKISAAQTRLSELHDE- 459
+Q + K+ ++R G L QLE++ +++ AQ +LSE
Sbjct: 1341 LQEETRAKLALGSRVRAMEAEAAG---LREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1397
Query: 460 ------IEKAEQQILRATEEFKQLEEAIQLKKIS----EAGKDLLYKQLSG-------RL 502
+E E+ RA E + L + + K + E G+ L ++L +
Sbjct: 1398 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1457
Query: 503 QLVNKLR------------QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
QLV+ L ++A L E+++ E G+++E + L + +L+ +
Sbjct: 1458 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT-RALEEEQEAR 1516
Query: 551 SHMKAQKSGKEQQLDIMNKQYQQLESRLDEI--LSRIAKETE-----EIKDLEEQLTEGQ 603
++ Q +L+ + + + E+ R+A++ ++ +LE++LT +
Sbjct: 1517 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1576
Query: 604 IA------ANEALK----KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
A +ALK +DL+G +E + Q A+ E + R ++ +
Sbjct: 1577 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1636
Query: 654 TEVEQERDQLEIVAMDA----ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
++E E ++L+ A E K+L ++++ ++E + ++ ++ + E E
Sbjct: 1637 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1696
Query: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ--- 766
RL +AE +L+EEL R + A Q E + L KA EEK Q
Sbjct: 1697 KRLKGLEAEVLRLQEELAASDR---ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1753
Query: 767 ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
+L +L+ Q ++ LL + + + + L +A+ + R++
Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ------- 1806
Query: 827 MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
L++Q E+ R E A+ R + +A + KLA +E+
Sbjct: 1807 ----------------LERQIQELRGRLGEEDAGARARHKM---TIAALESKLAQAEEQL 1847
Query: 887 RQAC-ERALEARM--NFDKRQHEARIQQMENE--IHYLQENLKSMEEIQGLTDLQLQEAD 941
Q ER L ++ +KR E +Q E L++ L+ QL+EA+
Sbjct: 1848 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1907
Query: 942 EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
EE R A R L+ ++LED E +++E+ L+ ++L LT +
Sbjct: 1908 EEASRAQAGRRRLQ--RELEDV--TESAESMNREVTTLR------NRLRRGPLTFTTRTV 1957
Query: 1002 KSLHGTVMKI-NQERAEELQ 1020
+ + + + E AEE Q
Sbjct: 1958 RQVFRLEEGVASDEEAEEAQ 1977
Score = 77.8 bits (190), Expect = 1e-13
Identities = 121/654 (18%), Positives = 273/654 (41%), Gaps = 69/654 (10%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD--LLQEKKSLECEVE 1378
L + ++L D + L+ + R + + + R E E L +++ +E+ E +
Sbjct: 1327 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1386
Query: 1379 ELHRTVQKRQQQKD---FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
+ + +R+Q+++ G E E + + + ++ +E+ + + EL
Sbjct: 1387 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1446
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET---AVNLV 1492
+A L + +S ++K + + + K ++L+ + E E +E A++L
Sbjct: 1447 DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1506
Query: 1493 KA-----------DQQLRSLQADAKDLEQHKIKQEEILKEINKIV-----AAKDSDFQCL 1536
+A ++Q R+L+A+ + L K + + E+ + AA D Q
Sbjct: 1507 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1566
Query: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE- 1595
+ E E KL+ ++ + H + E + +R ++L+ + +E
Sbjct: 1567 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1626
Query: 1596 ----MAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
+AV R+ L + EEL S Q K + + LR + ++ E + E ++ E
Sbjct: 1627 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1686
Query: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN-------ILD 1703
E+ Q E ++ + ++ +++E+ + + + + E+ N IL+
Sbjct: 1687 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1746
Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK-----LELENLQ-QISQQQK--GEIE 1755
E +L+G Q ++ + E E++ +L ++ L++E+L ++S ++ + E
Sbjct: 1747 ----EKRQLEGRLGQLEEELEE-EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1801
Query: 1756 WQKQLLERDKREIERMTAESRA---------LQSCVECLSKEKEDLQEKCD--IWEKKLA 1804
+Q LER +E+ E A + + L++ +E L+++ I KL
Sbjct: 1802 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1861
Query: 1805 QT-----KRVLAAAEENSKME---QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
+ K V+ EE ++ + LEK L V++L+++L++ + +Q
Sbjct: 1862 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1921
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
++L++ E+ S+ E+ +++ L T Q L E ++ E
Sbjct: 1922 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1975
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 157 bits (396), Expect = 1e-37
Identities = 223/1044 (21%), Positives = 430/1044 (41%), Gaps = 144/1044 (13%)
Query: 1324 EVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE--------- 1374
+V+R ++++Q ++ +E + ++ ++QS +E+ EL + L +E+ L
Sbjct: 904 QVTRQDEVLQ---ARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 960
Query: 1375 -CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
E EE + R+Q+ + + E+E + E+ +++ +K L +
Sbjct: 961 CAEAEETRGRLAARKQELELVVS---------ELEARVGEEEECSRQMQTEKKRLQQHIQ 1011
Query: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
EL A +L K T+ ++KF + LL E +L + + L +
Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKF---EEDLLLLEDQNSKLSKERKLLEDRLAE 1068
Query: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
Q + K L + ++K E A +D + +K+EK +EL+KL++
Sbjct: 1069 FSSQAAEEEEKVKSLNKLRLKYE-----------ATIADMEDRLRKEEKGRQELEKLKRR 1117
Query: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL- 1612
++ E +L+ Q+ QQQ L QLG K+EEL
Sbjct: 1118 LD------------------------GESSELQEQMVEQQQRAEELRAQLGRKEEELQAA 1153
Query: 1613 -------------LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
L S+ +A+A L EA E+E + ++ + L EEL +GEL
Sbjct: 1154 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1213
Query: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQ 1718
+ Q QE+ + E + TELK L + ++ +Q L+ +
Sbjct: 1214 EDTLDSTNAQ-----QELRSKRE----------QEVTELKKTLEEETRIHEAAVQELRQR 1258
Query: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
H Q + EL +Q+ Q ++G+ W+K L + E+ + AE +L
Sbjct: 1259 HGQALGEL----------------AEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1301
Query: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
Q+ + + + L+ + + + +R A A E + Q+ LE + + + + +
Sbjct: 1302 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1361
Query: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
+L+++ S + Q+ LQE+ A +L + ++ ++ L ++
Sbjct: 1362 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAG 1421
Query: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE 1958
E Q +SEW R E+ E ++ + E E +L ++ RL++ R
Sbjct: 1422 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1481
Query: 1959 SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER----WCE 2014
+ +L+ + + L EQQ QL L ++ K DQ+L++ AA +R ++E ER E
Sbjct: 1482 RLQQELDDATMDL-EQQRQLVSTLEKKQRKFDQLLAEEKAAV--LRAVEERERAEAEGRE 1538
Query: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
+ LS T+ E EQ+ E+ L+++ ++RA+ L L+ + K V
Sbjct: 1539 REARALSLTR--ALEEEQEAREE------LERQNRALRAELEAL----LSSKDDVGKSVH 1586
Query: 2075 SLKEALKIQR---SQLEKNLLEQKQENSCIQKEMATIELVAQ---DNHERARRLMKELNQ 2128
L+ A ++ + L + E + E + + +E+ Q HER + E +
Sbjct: 1587 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1646
Query: 2129 MQYEYTELKKQMAN---QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 2185
+ +L KQ+ + ++D ER+Q ++ A R +E++ + + Q E
Sbjct: 1647 ERRR--QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1704
Query: 2186 LEAILERNENLEGELESLKENLPFTMNEGPFEEK----LNFSQVHIMDEHWRGEALREKL 2241
L + + + L E+E + + ++ EK L + + +E + R +
Sbjct: 1705 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1764
Query: 2242 RHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
+ D + ++ + +A +L + KRQ EG L L +++ E S + L
Sbjct: 1765 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEE--EQSNSELLNDRYRKLL 1821
Query: 2302 SQLESSLTEDSQLGQNQEKNASAR 2325
Q+ES TE S K S R
Sbjct: 1822 LQVESLTTELSAERSFSAKAESGR 1845
Score = 145 bits (367), Expect = 3e-34
Identities = 220/1036 (21%), Positives = 441/1036 (42%), Gaps = 139/1036 (13%)
Query: 1368 QEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKS-----LKHHEDIVDEIE 1422
++ + L+ +EL + VQ+ QQQ G ++ + +LE E++ L+ ++ E E
Sbjct: 907 RQDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 965
Query: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
L R+ EL + +++E E+ + +E ++ + ++ + + E+ E E
Sbjct: 966 ETRGRLAARKQEL---ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022
Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
Q+ + V + +++ + D LE K L + K++ + ++F + ++E+
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK----LSKERKLLEDRLAEFSSQAAEEEE 1078
Query: 1543 LTEELQKLQ-------KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
+ L KL+ D+E R E+ Q L++ + L + +EL++ Q+ QQQ
Sbjct: 1079 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQR 1135
Query: 1596 MAVLDRQLGHKKEELHL--------------LQGSMVQAKADLQEALRLGETEVTEKCNH 1641
L QLG K+EEL L S+ +A+A L EA E+E +
Sbjct: 1136 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1195
Query: 1642 IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
++ + L EEL +GEL + Q QE+ + E + TELK
Sbjct: 1196 EKQRRDLGEELEALRGELEDTLDSTNAQ-----QELRSKRE----------QEVTELKKT 1240
Query: 1702 LDM-LQLENHELQGLKLQHDQRVSEL--------------EKTQVA----VLEEKLELEN 1742
L+ ++ +Q L+ +H Q + EL EKT++A V E + EL +
Sbjct: 1241 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1300
Query: 1743 LQ---QISQQQKGEIEWQKQ------------------LLERDKREIERMTAESRALQSC 1781
LQ Q +Q++ +E Q Q L+R + E+E ++ +S
Sbjct: 1301 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1360
Query: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
LSKE + + ++ L + R A + ++ L + + ++
Sbjct: 1361 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1420
Query: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
R+ + +S +++ +E+ A+ + +E Q L T+ D L +
Sbjct: 1421 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1480
Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
RLQ+++ + E ++ T +++ + + E K +++ +R + E E
Sbjct: 1481 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1540
Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV-RTLQEEERWCESLEKTL 2020
++ + L+E+Q + +EL Q L L +L++++ V +++ E ER C E+
Sbjct: 1541 ARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA 1599
Query: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRA----DFSLLRNQFLTERKKAEKQVASL 2076
+ + Q++E E +L L L+ +++ D R++ KQ+
Sbjct: 1600 NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA 1659
Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
+ +R Q + +K+ +++ A + Q E ++L K QM+ + E+
Sbjct: 1660 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1719
Query: 2137 KKQMANQKDLERRQMEISDAMRTLKSEV---KDEIRTS---LKNLNQFLPELPADL---- 2186
++ +++++ + E ++ L++EV ++E+ S + Q E+ ++
Sbjct: 1720 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN 1779
Query: 2187 ---EAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRH 2243
AILE LEG L L+E L EE+ + S+ ++++ +R KL
Sbjct: 1780 LSKAAILEEKRQLEGRLGQLEEEL---------EEEQSNSE--LLNDRYR------KLLL 1822
Query: 2244 REDRLKAQL--RHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSL 2301
+ + L +L S +AE G++Q E + LR + LGE A + ++
Sbjct: 1823 QVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGR---LGE--EDAGARARHKMTI 1874
Query: 2302 SQLESSLTE-DSQLGQ 2316
+ LES L + + QL Q
Sbjct: 1875 AALESKLAQAEEQLEQ 1890
Score = 116 bits (290), Expect = 3e-25
Identities = 203/951 (21%), Positives = 386/951 (40%), Gaps = 131/951 (13%)
Query: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECE 1376
++ L E LED + S+ EE S + + E +++D L++++ E
Sbjct: 1051 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1110
Query: 1377 VEELHRTVQ----KRQQQKDFIDGNVESLMTEL-----EIEKSLKHHEDIVDEIECIEKT 1427
+E+L R + + Q+Q E L +L E++ +L ED
Sbjct: 1111 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA----RAQ 1166
Query: 1428 LLKRRSELREADRLLAEAESELSCTK------EKTKNAVEKFTDAKRSLLQTESDA---- 1477
LLK LREA LAEA+ +L + EK + + + +A R L+ D+
Sbjct: 1167 LLK---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1223
Query: 1478 EELERRAQETAVNLVKA-DQQLRSLQADAKDLEQHKIKQ----EEILKEINKIVAAKDSD 1532
+EL + ++ L K +++ R +A ++L Q + E L++ + A +
Sbjct: 1224 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1283
Query: 1533 FQCLSKKKEKLTEELQKLQ---KDIEMAERNEDHHLQVLK-----------ESEVLLQAK 1578
L + +L EL LQ ++ E R + LQ ++ E+ LQ
Sbjct: 1284 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 1343
Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEV 1635
+AELE + + + + L ++L + +LH Q + +AK L +R E E
Sbjct: 1344 QAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEA 1403
Query: 1636 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ---MS 1692
+ E + E + Q+SE + + +E EE + R+ ++
Sbjct: 1404 AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALT 1463
Query: 1693 KHKTELKNILDMLQLENHELQG------LKL-QHDQRVSELEKTQ----VAVLEEKLELE 1741
+ E +D L+ LQ + L Q Q VS LEK Q + EEK +
Sbjct: 1464 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV- 1522
Query: 1742 NLQQISQQQKGEIEWQKQ---------LLERDKREIERMTAESRALQSCVECLSKEKED- 1791
L+ + ++++ E E +++ LE ++ E + ++RAL++ +E L K+D
Sbjct: 1523 -LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1581
Query: 1792 ------LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR--KLQQELDQLNR 1843
L+ C + E+ + + E+ + +LE+ V+ K Q E D R
Sbjct: 1582 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1641
Query: 1844 DKLS------LHNDISAMQQQLQEKRE-------AVNSLQEELANVQDHLNLAKQDLLHT 1890
D+ L + + + E+R+ A L+ EL ++ + A Q
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1701
Query: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
K + ++ L +++ E E+ + +++L+ L+ E+ + +L +
Sbjct: 1702 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1761
Query: 1951 QRLQKERES---EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSK-----------V 1996
++ Q++R+ E + SK + E++ QLE L + +L++ S +
Sbjct: 1762 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1821
Query: 1997 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQK------EADS 2050
L E L E + E Q +RQ+ E +L E+ A K E+
Sbjct: 1822 LQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKL 1881
Query: 2051 MRADFSL---LRNQFLTER--KKAEKQ----VASLKEALKIQ---RSQLEKNLLEQKQEN 2098
+A+ L R + L+ + ++AEK+ V ++E ++ R QLEK L KQ
Sbjct: 1882 AQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ-- 1939
Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
+++++ E A RRL +EL + + +++ ++ RR
Sbjct: 1940 --LKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988
Score = 113 bits (282), Expect = 2e-24
Identities = 176/868 (20%), Positives = 361/868 (41%), Gaps = 136/868 (15%)
Query: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLL------QEKKSL 1373
+L + L + + L+S++ +R +E+E L ++D L QE +S
Sbjct: 1170 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1229
Query: 1374 -ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI-ECIEKTLLKR 1431
E EV EL +T+++ E+ + E +++ + H + E+ E +E+ +R
Sbjct: 1230 REQEVTELKKTLEE------------ETRIHEAAVQELRQRHGQALGELAEQLEQA--RR 1275
Query: 1432 RSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
E RL EAE +ELS + + ++ + L + + A + ER E
Sbjct: 1276 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1335
Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIK--------------QEEILKEINKIVAAKDSD 1532
A L +A +L ++ + E I+ +E+L+E + A S
Sbjct: 1336 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1395
Query: 1533 FQCLSKK--------------KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
+ + + +E+ ELQ Q + R ++ L+ E +
Sbjct: 1396 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1455
Query: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
E E L ++ + + + L+R G ++ LQ + A DL++ +L T ++
Sbjct: 1456 AREAEALTQRLAEKTETVDRLER--GRRR-----LQQELDDATMDLEQQRQLVSTLEKKQ 1508
Query: 1639 CNH---IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHK 1695
+ E K+ + ++ + ER+ + + + +E+E+E + + RQ +
Sbjct: 1509 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1568
Query: 1696 TELKNIL---DMLQLENHELQGLKLQHDQ-------RVSELEKTQVAVLEEKLELE-NLQ 1744
EL+ +L D + HEL+ +Q +V+ELE A + KL LE +Q
Sbjct: 1569 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1628
Query: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK-- 1802
+ Q + +++ + + E +R++ + ++ + +++E Q + +K
Sbjct: 1629 ALKTQHERDLQGRDEAGEERRRQLAKQLRDAE--------VERDEERKQRTLAVAARKKL 1680
Query: 1803 ---LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL 1859
L + K +A+A + + L K++ +++L +E+++ + + + +++L
Sbjct: 1681 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1740
Query: 1860 QEKREAVNSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDISEWA 1912
+ V LQEELA A+QD + + + +L E+ +L+ + +
Sbjct: 1741 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1800
Query: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLK 1972
E+ Q E + + L ++E +L + + + R+ E +++ + L
Sbjct: 1801 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1860
Query: 1973 EQ------QHQ-----LEKELTDQKSKLDQ-----VLSKVLA--AEERVRTL----QEEE 2010
E+ +H+ LE +L + +L+Q +LS L AE+R++ + +EE
Sbjct: 1861 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1920
Query: 2011 RWCESLEKTLS-------QTKRQLSEREQQLVEKSGELLALQKE-------ADSMRADFS 2056
R + L L Q KRQL E E++ LQ+E A+SM + +
Sbjct: 1921 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1980
Query: 2057 LLRNQF----LTERKKAEKQVASLKEAL 2080
LRN+ LT + +QV L+E +
Sbjct: 1981 TLRNRLRRGPLTFTTRTVRQVFRLEEGV 2008
Score = 107 bits (267), Expect = 1e-22
Identities = 198/959 (20%), Positives = 406/959 (42%), Gaps = 110/959 (11%)
Query: 255 VTTQDRQEAFERFSLEEVERLERDLEKKMIETE----ELKSKQTRFLEEIKNQDKLNKSL 310
VT QD L++V+ L++ +++ E + +L+ ++ R E+++ + +L
Sbjct: 905 VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 964
Query: 311 KE---EAMLQKQSCE----ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
+E +KQ E EL++ + + E +Q E R Q ELE L +
Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 1024
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
+ L +E A++ K ++ + K + + D + E +E+++
Sbjct: 1025 QKLQLEKVTTE-AKMKKFEEDLLLLEDQNSK--LSKERKLLEDRLAEFSSQAAEEEEKVK 1081
Query: 424 NDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL 483
+ + + +ED+ +K + L +L ++ ++ E +Q E ++
Sbjct: 1082 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141
Query: 484 ---KKISEAGKDLLYKQLSG--RLQLVNKLRQ-EALDLELQMEKQKQEIAGK--QKEIKD 535
+K E L + G R QL+ LR+ +A E Q + + + +A +K+ +D
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1201
Query: 536 LQIAIDSL-----DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL----ESRLDEILSRIA 586
L +++L D+ D ++ + +S +EQ++ + K ++ E+ + E+ R
Sbjct: 1202 LGEELEALRGELEDTLDSTNAQQEL-RSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 587 KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK 646
+ E+ + EQ G+ A E + LE +S L+ L +++ + + R+L +
Sbjct: 1261 QALGELAEQLEQARRGK-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1319
Query: 647 ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
+ + R + E+ R A AE +++ AELE+ +E + + +LS+ EA
Sbjct: 1320 QEVQGRAGDGERAR------AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1373
Query: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA-----LGKAQFS 761
+L L E + K L R + E + L+ +LE+E A + A +AQ S
Sbjct: 1374 QLHDAQELLQEET-RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1432
Query: 762 EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
E + ++ E A L+ ++ ++ + + L E R++ RR+L+
Sbjct: 1433 EWRRRQEEEAGA----LEAGEEARRRAAREAEA----LTQRLAEKTETVDRLERGRRRLQ 1484
Query: 822 --LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---------ERDEAQVRERKLQ- 869
L M++ ++ +L Q++F ++LA K ER EA+ RER+ +
Sbjct: 1485 QELDDATMDLEQQRQLVS-TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1543
Query: 870 -------EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE---------------- 906
EE +E+L R E L ++ + K HE
Sbjct: 1544 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1603
Query: 907 ARIQQMENEIHYLQENLKSME------EIQGLTDLQ-LQEADEEKERILA-QLRELE--- 955
A++ ++E+E+ ++ +E + Q DLQ EA EE+ R LA QLR+ E
Sbjct: 1604 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1663
Query: 956 ---KKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
+K++ +++++ G +ELK + + A +L + Q+K L V +
Sbjct: 1664 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1723
Query: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-EKTGVGTGAN 1071
R E + ++ ++ R + E+ + R++ +Q R EM ++ G +
Sbjct: 1724 TSREEIFSQNRESEKRLKGLEAEVLRLQEEL-AASDRARRQAQQDRDEMADEVANGNLSK 1782
Query: 1072 SQVLEIEK-LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
+ +LE ++ L + + E+ Q+ +L + +L ++ L E+S + +
Sbjct: 1783 AAILEEKRQLEGRLGQLEEELEEEQSNSELLND----RYRKLLLQVESLTTELSAERSF 1837
Score = 82.8 bits (203), Expect = 4e-15
Identities = 180/860 (20%), Positives = 350/860 (40%), Gaps = 133/860 (15%)
Query: 247 LESLEGQPVTTQDRQEAFERFSL---EEVERLERDLEKKM----IETEELKSKQTRFLEE 299
LE+L G+ T D A + +EV L++ LE++ +EL+ + + L E
Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1265
Query: 300 IKNQ---DKLNKSLKEEAMLQKQS-CEELKSDLNTKNELLKQKTIELTRACQKQYELEQE 355
+ Q + K E+ L ++ EL+++L++ + +Q+ + R + Q + Q
Sbjct: 1266 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL-QTARQEGEQRRRRLELQLQEVQG 1324
Query: 356 LAFYKIDAKFEPLNYYPSEYAEIDKAPD-----ESPYIGKSRYKRNMFATESYIIDSAQA 410
A A+ E AE++ ES I R + + +TE+ + D+ +
Sbjct: 1325 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTI---RLSKELSSTEAQLHDAQEL 1381
Query: 411 VQIK---KMEPDEQLRNDHMNLRGHTPLDTQLEDKE-------KKISAAQTRLSELHDE- 459
+Q + K+ ++R G L QLE++ +++ AQ +LSE
Sbjct: 1382 LQEETRAKLALGSRVRAMEAEAAG---LREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1438
Query: 460 ------IEKAEQQILRATEEFKQLEEAIQLKKIS----EAGKDLLYKQLSG-------RL 502
+E E+ RA E + L + + K + E G+ L ++L +
Sbjct: 1439 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1498
Query: 503 QLVNKLR------------QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
QLV+ L ++A L E+++ E G+++E + L + +L+ +
Sbjct: 1499 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT-RALEEEQEAR 1557
Query: 551 SHMKAQKSGKEQQLDIMNKQYQQLESRLDEI--LSRIAKETE-----EIKDLEEQLTEGQ 603
++ Q +L+ + + + E+ R+A++ ++ +LE++LT +
Sbjct: 1558 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1617
Query: 604 IA------ANEALK----KDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL 653
A +ALK +DL+G +E + Q A+ E + R ++ +
Sbjct: 1618 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1677
Query: 654 TEVEQERDQLEIVAMDA----ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
++E E ++L+ A E K+L ++++ ++E + ++ ++ + E E
Sbjct: 1678 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1737
Query: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ--- 766
RL +AE +L+EEL R + A Q E + L KA EEK Q
Sbjct: 1738 KRLKGLEAEVLRLQEELAASDR---ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1794
Query: 767 ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
+L +L+ Q ++ LL + + + + L +A+ + R++
Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ------- 1847
Query: 827 MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
L++Q E+ R E A+ R + +A + KLA +E+
Sbjct: 1848 ----------------LERQIQELRGRLGEEDAGARARHKM---TIAALESKLAQAEEQL 1888
Query: 887 RQAC-ERALEARM--NFDKRQHEARIQQMENE--IHYLQENLKSMEEIQGLTDLQLQEAD 941
Q ER L ++ +KR E +Q E L++ L+ QL+EA+
Sbjct: 1889 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1948
Query: 942 EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQL 1001
EE R A R L+ ++LED E +++E+ L+ ++L LT +
Sbjct: 1949 EEASRAQAGRRRLQ--RELEDV--TESAESMNREVTTLR------NRLRRGPLTFTTRTV 1998
Query: 1002 KSLHGTVMKI-NQERAEELQ 1020
+ + + + E AEE Q
Sbjct: 1999 RQVFRLEEGVASDEEAEEAQ 2018
Score = 77.8 bits (190), Expect = 1e-13
Identities = 121/654 (18%), Positives = 273/654 (41%), Gaps = 69/654 (10%)
Query: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDD--LLQEKKSLECEVE 1378
L + ++L D + L+ + R + + + R E E L +++ +E+ E +
Sbjct: 1368 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1427
Query: 1379 ELHRTVQKRQQQKD---FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL 1435
+ + +R+Q+++ G E E + + + ++ +E+ + + EL
Sbjct: 1428 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1487
Query: 1436 READRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET---AVNLV 1492
+A L + +S ++K + + + K ++L+ + E E +E A++L
Sbjct: 1488 DDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1547
Query: 1493 KA-----------DQQLRSLQADAKDLEQHKIKQEEILKEINKIV-----AAKDSDFQCL 1536
+A ++Q R+L+A+ + L K + + E+ + AA D Q
Sbjct: 1548 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1607
Query: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE- 1595
+ E E KL+ ++ + H + E + +R ++L+ + +E
Sbjct: 1608 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1667
Query: 1596 ----MAVLDRQ-LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650
+AV R+ L + EEL S Q K + + LR + ++ E + E ++ E
Sbjct: 1668 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1727
Query: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN-------ILD 1703
E+ Q E ++ + ++ +++E+ + + + + E+ N IL+
Sbjct: 1728 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1787
Query: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEK-----LELENLQ-QISQQQK--GEIE 1755
E +L+G Q ++ + E E++ +L ++ L++E+L ++S ++ + E
Sbjct: 1788 ----EKRQLEGRLGQLEEELEE-EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1842
Query: 1756 WQKQLLERDKREIERMTAESRA---------LQSCVECLSKEKEDLQEKCD--IWEKKLA 1804
+Q LER +E+ E A + + L++ +E L+++ I KL
Sbjct: 1843 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1902
Query: 1805 QT-----KRVLAAAEENSKME---QSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQ 1856
+ K V+ EE ++ + LEK L V++L+++L++ + +Q
Sbjct: 1903 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1962
Query: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
++L++ E+ S+ E+ +++ L T Q L E ++ E
Sbjct: 1963 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 2016
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 157 bits (396), Expect = 1e-37
Identities = 220/1037 (21%), Positives = 456/1037 (43%), Gaps = 187/1037 (18%)
Query: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQS----EKEMEELHHNIDDLLQEKKSLECEV 1377
+ +V L + M+ L SK + +K ++ EK + EL DL ++ + C+
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECI-----------EK 1426
+EL + V+ E L ++LE+ EDI D + + E
Sbjct: 1854 QELLQRVETS-----------EGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVEN 1902
Query: 1427 TLLKRRSELR--EADRLLAEAESELS-----CTKEKTKNAVEKFTDAKRSLLQTESDAEE 1479
L + RSE E + L EA+ E+ C ++ +N + + L S+ +
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962
Query: 1480 LERRAQETAVNLVKADQQLRSLQADAKDLEQHKIK-------QEEILKEINKIVAAKDSD 1532
L + DQ ++ ++LE H+ + E +KE +++ SD
Sbjct: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD 2022
Query: 1533 FQCLSKKKEKLTEELQKLQKDI------------EMAERNEDHHLQVLKESEVLLQAKRA 1580
L K K L E+LQ L+KD ++A+ N++ L ++KESE LQA+ +
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL-LVKESE-SLQARLS 2080
Query: 1581 ELEKLKSQVTSQQQEMAVLDR-----QLGHKKEELHLLQGSM----VQAKADLQEALRLG 1631
E + K V S+ E A++++ +L +EE+H L+ + V+ +AD ++ L +
Sbjct: 2081 ESDYEKLNV-SKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
Query: 1632 ETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE-ENLQVVLRQ 1690
E ++ E+ +K +E L E +Q+SE +L ++ E K E E L+ + +
Sbjct: 2140 E-KLKERERENDSLKDKVENL-----ERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193
Query: 1691 MSKH-----------KTELKNILDMLQLENHELQGL-------------KLQHDQRVSEL 1726
M++ ++E +N+ +Q + +L L K Q + ++ E
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 1727 EKTQVAVLEEKL------------ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE 1774
KT V +L+ +L + E ++ Q IE + QL + IE++ A
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQL----RNSIEKLRAR 2309
Query: 1775 SRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAA---EENSKMEQSN----LEKL 1827
A + C+ ++ ++ + D+ + ++ +R L A +E++ +E N +E L
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 1828 ELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL 1887
+ + + Q L L D +++ ++ + +LQ+++E ++ L+ ++ ++ L +Q+
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429
Query: 1888 LH----TTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQ---------- 1933
+ ++ ++L ++ L + ++ N E C+ +E+ Q++ L+
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
Query: 1934 ------------------NEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQ 1975
E+E+ K KL +++ RL+ + + +E + SK++ E +
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV--SKLSQVEGE 2547
Query: 1976 HQLEKE--------LTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
HQL KE + + K+ + SK + ++ + LQ + E+ + K
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
Query: 2028 SEREQQLVEKSGELL----ALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK-- 2081
E+ ++ K EL + ++ ++ + S +N+ E + +++ S K+ LK
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Query: 2082 -IQRSQLEKNL----LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYE---Y 2133
++ S+L+K+L +Q ++ +++E+A +L + ++ + L+ + N+ QYE
Sbjct: 2668 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNK-QYEVEIQ 2726
Query: 2134 TELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD-------L 2186
T +K + ++ L +++EI LKS K+E+ SLK Q L EL +
Sbjct: 2727 TYREKLTSKEECLSSQKLEID----LLKSS-KEELNNSLKATTQILEELKKTKMDNLKYV 2781
Query: 2187 EAILERNENLEGELESL 2203
+ + NE +G+++ L
Sbjct: 2782 NQLKKENERAQGKMKLL 2798
Score = 150 bits (378), Expect = 2e-35
Identities = 177/852 (20%), Positives = 372/852 (43%), Gaps = 113/852 (13%)
Query: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK 1386
RL + + +R +R EK+ + + + +E SL+ +VE L R +Q
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165
Query: 1387 RQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAE 1446
++ ++ + + E+ E+E K+ E++ ++ E L+ RSE + + E +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKT--QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 1447 SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAK 1506
+LS ++K + +SLL+ + AE + +TAV +++
Sbjct: 2224 GQLS--------ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ----------- 2264
Query: 1507 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1566
LKE+N+ VAA D + + K TE Q L IE E+H L
Sbjct: 2265 ------------LKELNEAVAALCGDQEIM-----KATE--QSLDPPIE-----EEHQL- 2299
Query: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQE 1626
R +EKL++++ + +++ + +QL + LL+G + + +L+
Sbjct: 2300 ------------RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI 2347
Query: 1627 ALRLGETEVTEKCNHIREVKSL---LEELSFQKGELNVQISERKTQLTLIKQEIEKEEEN 1683
A E E N EV++L +E ++ L + + +++ + E++KE+E
Sbjct: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
Query: 1684 LQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLE-LEN 1742
+ ++ + +NIL + E +++ + E+ +TQ+ L E++ L N
Sbjct: 2408 IS----ELEIINSSFENILQEKEQEKVQMK----EKSSTAMEMLQTQLKELNERVAALHN 2459
Query: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMTAESR----ALQSCVECLSKEKEDLQEKCDI 1798
Q+ + ++ + Q + LE +K ++ + E++ LQS V L +E ED ++K +
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
Query: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
++++++ K + ++ + S L ++E + +++ +L + L I +Q +
Sbjct: 2520 KDEEISRLKNQI----QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
++ + LQ N+++ L L K D + + + + +++T LQ+++ E A + +
Sbjct: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635
Query: 1919 QKEEETKQQ----QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 1974
Q+E ++ +LQ+L EI+ +K +L KE E S+L+ S + +
Sbjct: 2636 QEELSGEKNRLAGELQLLLEEIKSSKDQL-----------KELTLENSELKKSLDCMHKD 2684
Query: 1975 QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQL 2034
Q + E ++ ++ AE ++R + E++ L T Q + ++ ++L
Sbjct: 2685 QVEKEGKVREE------------IAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732
Query: 2035 VEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ 2094
K L + + E D +++ L N K + E LK + K + +
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKEELNNSL--------KATTQILEELKKTKMDNLKYVNQL 2784
Query: 2095 KQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
K+EN Q +M + + E L KEL+Q+Q + K ++ EI
Sbjct: 2785 KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIK 2844
Query: 2155 DAMRTLKSEVKD 2166
+ TL+ + K+
Sbjct: 2845 ELKETLEEKTKE 2856
Score = 133 bits (335), Expect = 2e-30
Identities = 185/969 (19%), Positives = 416/969 (42%), Gaps = 135/969 (13%)
Query: 1342 ERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQK---------- 1391
E W ++ ++++EL +D L +EK+ + +++ L +QK++Q+
Sbjct: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL 65
Query: 1392 -----------DFIDGNVESLMTELEIEKSLKHHED-----IVDEIECIEKTLLKRRSEL 1435
+ ++ + + EL++++S + ++ +IE +E+ L + +SEL
Sbjct: 66 KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSEL 125
Query: 1436 READRLLAEAESELSCTKEKTK------NAVEKFTDAKRSLLQTESDAEELERR---AQE 1486
+ + A+ L+ K + ++ +K L+ + + E ER+ A+
Sbjct: 126 ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE----- 1541
A+ KA Q L + +D+ +H+ + K + S+ Q +++
Sbjct: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
Query: 1542 -KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD 1600
+E+ + +++ +R+ + S LL +A+ ++L++++ + + +
Sbjct: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
Query: 1601 RQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNH------------------- 1641
+++ + + LQ + +AK +L E + +V KC
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIE-----KEKVLNKCRDELVRTTAQYDQASTKYTAL 360
Query: 1642 IREVKSLLEELSFQKG-------ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKH 1694
+++K L E+LS Q+ L +I E++ + ++E+ +++ + Q + ++ +
Sbjct: 361 EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE---FQEELSRQQRSFQTLDQECIQM 417
Query: 1695 KTEL-------KNILDMLQLENHELQGLKLQHDQRVSELE----KTQVAVLEEKLELENL 1743
K L KN+ ++LQ E +L +K Q + + E + + + A +++ L
Sbjct: 418 KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENEL 477
Query: 1744 QQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV--------ECLSKEK------ 1789
++ ++ K E K E+ RE+ + AE + ++ C+ E +K
Sbjct: 478 RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 1790 EDLQEKCDIWEKKLAQTKRVLAAA--EENSKMEQSNLEKLELNVRKLQQELDQLNRDKLS 1847
DLQEK + E L K LA A E+ Q L+K E ++ +L +L + ++ +
Sbjct: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
Query: 1848 LHNDISAMQ------QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
L +SA++ ++L+E++ + + E + + K++L H + L Q
Sbjct: 598 L---LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
Q E+ R + + E +++ L N ++ +++ Q++ + LQ++ E +
Sbjct: 655 ---QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD 711
Query: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLS 2021
K + + + QL ++ D + KL + ++++ ++ R Q+ ESL L
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM---DKDRCYQDLHAEYESLRDLLK 768
Query: 2022 QTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQV---ASLKE 2078
L E + LLA ++ + +++ Q +++E ++ S K
Sbjct: 769 SKDASLVTNE----DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN 824
Query: 2079 ALKIQR--SQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
+ +Q LE +L QKQ NS +QK+ E + Q E LMK Q E
Sbjct: 825 SAILQNRVDSLEFSLESQKQMNSDLQKQ---CEELVQIKGEIEENLMKAEQMHQSFVAET 881
Query: 2137 KKQMAN-QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN 2195
++++ Q+D Q +++ + L+++ K+ L+ LN + A+++ + + N
Sbjct: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKE-----LQLLNDKVETEQAEIQELKKSNHL 936
Query: 2196 LEGELESLK 2204
LE L+ L+
Sbjct: 937 LEDSLKELQ 945
Score = 128 bits (321), Expect = 7e-29
Identities = 178/882 (20%), Positives = 367/882 (41%), Gaps = 94/882 (10%)
Query: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTV------QKRQQQKDFIDGNVESL 1401
S+ S + E+L + ++E+K LE EV+ L Q +D S
Sbjct: 156 SQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSS 215
Query: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKR--RSELREADRLLAEAESELSCTKEKTKNA 1459
+ + EK+ H ++T ++R + ++ + + S L K ++
Sbjct: 216 VFSWQQEKTPSHLSSNS------QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSS 269
Query: 1460 VEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS-------LQADAKDLEQHK 1512
+ + L Q ++ +EL + E + L +++++ LQ + +
Sbjct: 270 FFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL 329
Query: 1513 IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESE 1572
I++E++L + + + + S K L ++L+KL +D+ +N + +
Sbjct: 330 IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAE-------SAR 382
Query: 1573 VLLQAKRAELEK-LKSQVTSQQQEMAVLDRQLGHKKEEL--HLLQG----SMVQAKAD-L 1624
L+ K E EK + +++ QQ+ LD++ K L L Q +++QA+ D L
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
+ E + E + + + ++ EL + E K + L+K E++
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA--- 499
Query: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAV--LEEKLELEN 1742
R++ + ELKNI L + + +K ++ + + L Q + E L LE
Sbjct: 500 ----REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMT-------AESRALQSCVECLSKEKEDLQEK 1795
L+ + + + + LL++ + IE++ ES+AL S +E KE E+L+E+
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
++ ++ +++L E + QS + LE ++ Q + + N +L D +
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 1856 QQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF 1915
+++ ++S E+ Q L + Q S+Q + QK+I +
Sbjct: 676 SVEIRNLHNVLDSKSVEVET---------QKLAYMELQQKAEFSDQ-KHQKEIENMCLKT 725
Query: 1916 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL-KEQ 1974
+ E + +LQ+L NEI + ++ +Q L E ES L++ +L +
Sbjct: 726 SQLTGQVEDLEHKLQLLSNEI-------MDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778
Query: 1975 QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE---------------ERWCESLEKT 2019
HQ DQ+ + + ++ + + + + E + +SLE +
Sbjct: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838
Query: 2020 LSQTKRQLSEREQQ---LVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASL 2076
L K+ S+ ++Q LV+ GE+ +A+ M F +Q ++ K ++ ++
Sbjct: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS---KLQEDTSAH 895
Query: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
+ + S LE E + N ++ E A I+ + + NH +KEL + +
Sbjct: 896 QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH-LLEDSLKELQLLSETLSLE 954
Query: 2137 KKQMANQKDLERRQM-EISDAMRTLKSEVKDEIRTSLKNLNQ 2177
KK+M++ L +R++ E++ TLK E+ + NL Q
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLK-EINASLNQEKMNLIQ 995
Score = 127 bits (319), Expect = 1e-28
Identities = 234/1048 (22%), Positives = 447/1048 (42%), Gaps = 168/1048 (16%)
Query: 96 NLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYN-LIGKIEKLDK-LLKLRELN 153
+L ++++ L L KD K K I LE+ +L V+ N L G+++ + K L +L+
Sbjct: 1924 DLEVVQTEKLCLEKDNENKQKVIVCLEE--ELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 154 LSYN-KISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDIS 212
K ++E ++ C L + +A E++ L + S V L +K + +
Sbjct: 1982 EKMKEKTQELESHQSEC-LHCIQVAEAEVKEKTELL--QTLSSDVSELLKDKTHLQEKLQ 2038
Query: 213 KLKPLQDLISLIL--VENPVVTLPHYLQFTIFHLRSLES-LEGQPVTTQDRQEAFE---- 265
L+ +SL +EN + L + + SL++ L + +A E
Sbjct: 2039 SLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALV 2098
Query: 266 ---RFSL------EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAML 316
F+L EEV +L R +EK + E + KQ E++K +++ N SLK++
Sbjct: 2099 EKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV-- 2156
Query: 317 QKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYA 376
E L+ +L E QEL A
Sbjct: 2157 -----ENLERELQMSEE-------------------NQELVILD---------------A 2177
Query: 377 EIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
E KA E+ ++ I + A+++++ +++ LR++ NL
Sbjct: 2178 ENSKAEVET--------------LKTQIEEMARSLKVFELDL-VTLRSEKENLT------ 2216
Query: 437 TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGKDLL 494
Q+++K+ ++S LS +E+ EQ ++ EE K E +Q LK+++EA L
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
Query: 495 YKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMK 554
Q + K +++LD ++ E Q + K + L++ + K +
Sbjct: 2277 GDQE------IMKATEQSLDPPIEEEHQLRNSIEKLRA---------RLEADEKKQLCVL 2321
Query: 555 AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDL 614
Q E D++ + + LE L+ IA+ +E LE + ++G++ E LK +
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELE-----IARTNQEHAALEAENSKGEV---ETLKAKI 2373
Query: 615 EGV---ISGLQEYLGTIKGQATQAQNECRKLRD---EKETLLQRLTEVEQERDQLEIVAM 668
EG+ + GL+ + TI+ + NE +K ++ E E + + QE++Q ++
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
Query: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK 728
+ + E+ L++ L+E +E A+L Q A E L +++ + E QL + L++
Sbjct: 2434 EKSSTAMEM--LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
Query: 729 VTR---LTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLL 785
+ Q + L E+E +Q L+ + + + Q+ +L +KL ++ ++ L
Sbjct: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW 2551
Query: 786 KQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK-LGTGEMNIHSPSDVLGKSLADLQ 844
K+Q + +N EL +K++ L + ++ +VL S +L+
Sbjct: 2552 KEQNLELRN-----------------LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594
Query: 845 KQFSEILARSKW----ERDEAQVRERKLQEEMALQQEKLATGQEEFRQACER-ALEARMN 899
+ E+ K + ++ +E +LQ EM +K A QEE R A E ++
Sbjct: 2595 NEL-ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 900 FDK-RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKK 958
++ + + +++++ E L+++L M + Q + +++E E + +L E EKK
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ---LRLHEAEKKH 2710
Query: 959 K---LEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK-SLHGTVMKINQE 1014
+ L+ K E +E K+ +S KL L +K++L SL T + +
Sbjct: 2711 QALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEEL 2770
Query: 1015 RAEEL----------QEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064
+ ++ +E ER K + + E E E+LQ L Q Q E +KT
Sbjct: 2771 KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL--QAAQEKQKT 2828
Query: 1065 G--VGTGANSQVLEIEKLNETMERQRTE 1090
G + T + EI++L ET+E + E
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKE 2856
Score = 123 bits (308), Expect = 2e-27
Identities = 204/1031 (19%), Positives = 429/1031 (41%), Gaps = 131/1031 (12%)
Query: 1314 NVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373
++ E N + LE + + +++ + ++ E +E+L+ + +E K+L
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 1374 ECEVEELHRTVQKRQQQKDFID---GNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLK 1430
+E + ++ +++K E L+T++E EK ++ + ++ +E KT
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEK--ENLQSKINHLETCLKTQQI 656
Query: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVE----KFTDAKRSLLQTESDAEELERRAQE 1486
+ E E R L LS N ++ + K + ++ + AE +++ Q+
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEE 1546
N+ QL +DLE HK L+ ++ + KD +Q L + E L +
Sbjct: 717 EIENMCLKTSQLTG---QVEDLE-HK------LQLLSNEIMDKDRCYQDLHAEYESLRDL 766
Query: 1547 LQKLQKDIEMAERNEDHHLQVLK-ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1605
L+ KD + NEDH +L + + + A + + + S++ E + +
Sbjct: 767 LKS--KDASLVT-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL---EADQ 820
Query: 1606 KKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ-IS 1664
+ +LQ + + L+ ++ +++ ++C + ++K +EE + +++ ++
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMN-SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA 879
Query: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
E +++ ++++ + + L + + EL+ + D ++ E E+Q LK +
Sbjct: 880 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLED 939
Query: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
L++ Q+ L E L LE + S ++ +KREIE +T E+ L+
Sbjct: 940 SLKELQL--LSETLSLEKKEMSS------------IISLNKREIEELTQENGTLKEINAS 985
Query: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
L++EK +L +K + + + + ++ ++ + K E+ L Q +
Sbjct: 986 LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL--------------QRCEE 1031
Query: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
+ + D+S + QEK + L E ++ ++ + L ++ E
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL------KEAFAKEHQEF 1085
Query: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
++ R ++ E ET Q Q L++E+ +N Q +SE L
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQ---QALRSEMTDN--------------QNNSKSEAGGL 1128
Query: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTK 2024
+ +TLKE+Q++++KE+ D + +Q L KV+ + + L+ E + K
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQ-LMKVMKTKHECQNLES--------EPIRNSVK 1179
Query: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADF----SLLRNQFLTERKKAEKQVASLKEAL 2080
+ SER Q + +L + DS A ++LRN+ L + +++EK+ L+ L
Sbjct: 1180 ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKEL-KLQESEKEKECLQHEL 1238
Query: 2081 KIQRSQLEKNLLE--QKQENSCIQK-EMATIELVAQDNHERARRLMKELNQMQYEYTELK 2137
+ R LE + L+ Q QE S ++ E+ E HE L N + L+
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE----LSTSQNDNAHLQCSLQ 1294
Query: 2138 KQMANQKDLERRQMEISDAMRTLKSEVKD---EIRTSLKNLNQFLPELPADLEAILERNE 2194
M +LE+ + L +E+ D E T+ + + + + +L +++ + + +
Sbjct: 1295 TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSG 1354
Query: 2195 NLEGEL----------ESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHR 2244
L GEL E E P ++ P +E ++ + + D+ E +
Sbjct: 1355 LLHGELVEDIPGGEFGEQPNEQHPVSL--APLDESNSYEHLTLSDK----EVQMHFAELQ 1408
Query: 2245 EDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQL 2304
E L Q H ++L Q + L+ VD+L + + S +L
Sbjct: 1409 EKFLSLQSEH------KILHDQHCQMSSKMSELQTYVDSL------KAENLVLSTNLRNF 1456
Query: 2305 ESSLTEDSQLG 2315
+ L ++ QLG
Sbjct: 1457 QGDLVKEMQLG 1467
Score = 111 bits (277), Expect = 9e-24
Identities = 234/1090 (21%), Positives = 446/1090 (40%), Gaps = 184/1090 (16%)
Query: 170 NLQKLNLAGNEIEHIPVWLGKKLKSL-----RVLNLKGNKISSLQDISKLKPLQDLISLI 224
+LQ+ NL E P ++L+SL + L K+ S Q I K K +Q+L L+
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMES-QGIMKNKEIQELEQLL 1588
Query: 225 LVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR-QEAFERFSLEEVERLERDLEKKM 283
E + L+ L Q ++ ++ Q+ +LE +L EKK
Sbjct: 1589 SSER----------------QELDCLRKQYLSENEQWQQKLTSVTLEMESKLAA--EKKQ 1630
Query: 284 IETEELKSKQTRFLEEIKNQDKLNKSL----KEEAML-QKQSCEELKSDLNTKNELLKQK 338
E L+ + R +++ D ++SL E+A+ + +SC+ K + E +
Sbjct: 1631 TEQLSLELEVARL--QLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKH 1688
Query: 339 TIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPD---ESPYIGKSRYKR 395
+ + C K + + L KI E P+ +++PD E P K++
Sbjct: 1689 DVH--QICDKDAQQDLNLDIEKIT---ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743
Query: 396 NMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQL----EDKEKKISAAQT 451
+ S+ +A V + + E + N + ++ + + +L ED+++K+ +
Sbjct: 1744 ECISELSFSGPNA-LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802
Query: 452 RLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGRLQLVNKLRQ 510
+ EL ++ E Q++ E +LE+ + +LKK + LS +L+ + Q
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKEN--------SDLSEKLEYFSCDHQ 1854
Query: 511 EALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQ 570
E L Q + + DL++ D +D + K S KE+ LD+
Sbjct: 1855 ELL----------QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDV---- 1900
Query: 571 YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEG---VISGLQEYLGT 627
E+ L I S A E LE L Q L+KD E VI L+E L
Sbjct: 1901 ----ENELSRIRSEKASIEHEALYLEADLEVVQ-TEKLCLEKDNENKQKVIVCLEEELSV 1955
Query: 628 IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ------------------------- 662
+ + Q + E + +K T L +L+E +E+ Q
Sbjct: 1956 VTSERNQLRGELDTM-SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTE 2014
Query: 663 -LEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL--EARLNLRDAEA 719
L+ ++ D + K+ L+ LQ + + +L T+ +L A+L E L ++++E+
Sbjct: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074
Query: 720 NQLK---EELEKVTRLTQLEQSALQ--------AELEKERQALKNALGKAQFSEEKEQEN 768
Q + + EK+ LE + ++ + ++E L+ + K + E + E
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD-EK 2133
Query: 769 SELH--AKLKHLQDDNNLLKQQLKDFQNHLN-----------HVVDGLVRPEEVAARVDE 815
+LH KLK + +N+ LK ++++ + L + E + +++E
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193
Query: 816 LRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEI---------LARSKWERDEAQVRE 865
+ R LK+ ++ + S + L K + + Q Q SE+ L K E+ E Q++E
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK-EQAEIQIKE 2252
Query: 866 RK------LQEEMALQQEKLAT--GQEEFRQACERALEARMNFDKRQHEARIQQMENEIH 917
LQ ++ E +A G +E +A E++L+ + + +H Q+ N I
Sbjct: 2253 ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI---EEEH-----QLRNSIE 2304
Query: 918 YLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELK 977
L+ L++ E+ Q QL+E++ + + ++ LE ++LE A++ ++ L+ E
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE--RELEIARTNQEHAALEAENS 2362
Query: 978 K-----LK-KAVATSDKLATAELTIA--KDQLKSLHGTVMKINQERAEELQEAER----- 1024
K LK K + L EL + + + ++L + K QER EL+
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK-EQERISELEIINSSFENI 2421
Query: 1025 FSRKAAQAARDLTRAEAEIELLQNLLRQKGE--------QFRLEMEKTGVGTGANSQVLE 1076
K + + ++ +E+LQ L++ E Q + ++ + + LE
Sbjct: 2422 LQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELE 2481
Query: 1077 IEKLNETMERQRTEIARLQ---NVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
+L + ++ + LQ N L D K E EEI+ L+ ++ Q +S +
Sbjct: 2482 KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL 2541
Query: 1134 ADPFKRRGYW 1143
+ W
Sbjct: 2542 SQVEGEHQLW 2551
Score = 110 bits (276), Expect = 1e-23
Identities = 227/1074 (21%), Positives = 449/1074 (41%), Gaps = 159/1074 (14%)
Query: 1377 VEELHRTVQKRQQQKDFIDGNVES--LMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
VEEL + +Q + ++ +ES +M EI++ + E++C+ K L +
Sbjct: 1549 VEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQ 1608
Query: 1435 LREA-DRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV---- 1489
++ + E ES+L+ K++T+ + A+ L + + L E A+
Sbjct: 1609 WQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRN 1668
Query: 1490 ---NLVKADQQLRSLQADAKDLEQ--HKIKQEEILKEINKIVA--------------AKD 1530
++ K + + D+ Q K Q+++ +I KI + D
Sbjct: 1669 ESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPD 1728
Query: 1531 SDFQCLSKKKEKLT------------------------EELQKLQKDIEMAERNEDHHLQ 1566
++++ + K + + E++ LQ ++ L
Sbjct: 1729 TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH 1788
Query: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAV-------LDRQLGHKKEELHLLQGSMVQ 1619
V+++ + +++ E+++L S++ Q+ ++ L++ +G K+E L +
Sbjct: 1789 VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
Query: 1620 AKADLQEALRLGETEVTEKCNHIREV---KSLLEELSFQKGELNVQISER----KTQLTL 1672
D QE L+ ET +E N E+ KS E++ ++N ER + +L+
Sbjct: 1849 FSCDHQELLQRVET--SEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906
Query: 1673 IKQE---IEKE----EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSE 1725
I+ E IE E E +L+VV + + + +N ++ EL + + +Q E
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE 1966
Query: 1726 LEK-----TQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
L+ T + L EK++ E Q++ Q + ++ + E++ T + L S
Sbjct: 1967 LDTMSKKTTALDQLSEKMK-EKTQELESHQSECLH----CIQVAEAEVKEKTELLQTLSS 2021
Query: 1781 CVECLSKEKEDLQEKCDIWEK-----------------KLAQTKRVLAAAEEN--SKMEQ 1821
V L K+K LQEK EK +L + K +L E+ +++ +
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 1822 SNLEKLE----------------LNVRKLQQELDQLNRDKLSLHNDISA-------MQQQ 1858
S+ EKL L + Q+E+ QL R L I A + ++
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
L+E+ +SL++++ N++ L +++++ + +E L+ I E A +
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMM---FQRLQKERESEESKL-ETSKVTLKEQ 1974
+ + T + + + L +I+E + +L + + + F+ L +E+E E ++ E SK ++
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261
Query: 1975 QHQLEKELTDQKSKL--DQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQ 2032
Q+QL KEL + + L DQ + K A E+ + EEE L ++ + + +L E+
Sbjct: 2262 QNQL-KELNEAVAALCGDQEIMK--ATEQSLDPPIEEE---HQLRNSIEKLRARLEADEK 2315
Query: 2033 QLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLL 2092
+ + +L + AD ++ L + R E AL+ + S+ E L
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE------HAALEAENSKGEVETL 2369
Query: 2093 EQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQME 2152
+ K E + + + +EL L EL + Q +EL+ ++ +++ + + +
Sbjct: 2370 KAKIEG--MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427
Query: 2153 ISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMN 2212
M+ S + ++T LK LN+ + L D EA + +NL ++E L E +
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL-ELEKAQLL 2486
Query: 2213 EGPFEEKLNF----SQVH-IMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGK 2267
+G E K N+ S V+ ++ E G+ EK RLK Q+ + E L+
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI-----QDQEQLVSKL 2541
Query: 2268 RQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKN 2321
Q EG H L ++ + EL T L +SL + ++ Q+ KN
Sbjct: 2542 SQVEGE-HQLWKEQNL--ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
Score = 109 bits (272), Expect = 4e-23
Identities = 196/908 (21%), Positives = 373/908 (41%), Gaps = 108/908 (11%)
Query: 276 ERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELL 335
+ D+ + +E ++ R L I+++D+ +SL E +L++K L
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM-----------KELDSKLHLQ 1814
Query: 336 KQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKR 395
+ + + AC + ++ EL D E L Y+ ++ E+ + + S +
Sbjct: 1815 EVQLMTKIEACIELEKIVGELKKENSDLS-EKLEYFSCDHQELLQRVETSEGLNSDLEMH 1873
Query: 396 NMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH-TPLDTQLEDKEKKISAAQTRLS 454
++ I D+ V E + N+ +R ++ + E + QT
Sbjct: 1874 ADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKL 1933
Query: 455 ELHDEIEKAEQQILRATEEFKQL-EEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
L + E ++ I+ EE + E QL+ D + K+ + QL K++++
Sbjct: 1934 CLEKDNENKQKVIVCLEEELSVVTSERNQLR----GELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 514 DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS------KDPKHSHMKAQKSGKEQQLDIM 567
+LE + I + E+K+ + +L S KD H K Q K+ Q +
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049
Query: 568 NKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY--- 624
K +LE+++ ++ +E + L+ +L+E + K LE + E+
Sbjct: 2050 TKC--ELENQIAQLNKEKELLVKESESLQARLSESDYEKLN-VSKALEAALVEKGEFALR 2106
Query: 625 LGTIKGQATQAQNECRKLR-----DEKETL--LQRLTEVEQERDQLEIVAMDAENMRKEL 677
L + + + Q + KLR DEK+ L ++L E E+E D L+ EN+ +EL
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD---KVENLEREL 2163
Query: 678 AELESALQEQHEVNASLQQTQGDLSAYEAELEAR---LNLRDAEANQLKEELEKVTRLTQ 734
E + Q V + ++ ++ + ++E L + + + L+ E E +T+ Q
Sbjct: 2164 QMSE---ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 735 LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQN 794
+Q L +EL+K + K+ L EEKEQ ++ + K + +L+ QLK+
Sbjct: 2221 EKQGQL-SELDKLLSSFKSLL------EEKEQAEIQIKEESKTAVE---MLQNQLKE--- 2267
Query: 795 HLNHVVDGLVRPEEVAARVDE-----LRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE 849
LN V L +E+ ++ + + +L + + + K + +Q E
Sbjct: 2268 -LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 850 ILARSKWERDEAQVRERKL------QEEMALQQEKLATGQEEFRQACERALEAR--MNFD 901
+ + + ER+L QE AL+ E E + E ++ + D
Sbjct: 2327 SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELD 2386
Query: 902 KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK-----------ERILAQ 950
+ + + NE+ QE + +E I + LQE ++EK E + Q
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 951 LRELEKK-----KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLH 1005
L+EL ++ E K++EQ E +L+KA L AK+ L
Sbjct: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG------LDEAKNNYIVLQ 2500
Query: 1006 GTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGE-----QFRLE 1060
+V + QE + Q+ E+ K + +R + + + +L+ L + +GE + LE
Sbjct: 2501 SSVNGLIQEVEDGKQKLEK---KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE 2557
Query: 1061 MEKTGVGTGANSQVLEIEK--LNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIA- 1117
+ V QVL+ + L +T+E ++ L+N L+LT D E V + A
Sbjct: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Query: 1118 --ELRREV 1123
EL+RE+
Sbjct: 2618 ETELQREM 2625
Score = 106 bits (264), Expect = 3e-22
Identities = 131/613 (21%), Positives = 276/613 (45%), Gaps = 90/613 (14%)
Query: 1319 HNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV- 1377
H+ + R+E++ + L+ + + S+ E+E L I+ + Q + LE +V
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
Query: 1378 ------EELHRTVQKRQQ---QKDFIDGNVESLMTELEIEK-SLKHHEDIVDEIECIEKT 1427
E L +QK Q+ + + I+ + E+++ E E EK +K E+ +
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448
Query: 1428 LLKRRSELREADRLLAEAE-----SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
L R D+ +A+ S++ C + + ++ +AK + + +S L +
Sbjct: 2449 ELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ 2508
Query: 1483 RAQETAVNLVKADQQLRSLQADAKDLEQ-----------HKIKQEEILKEINKIVAAKDS 1531
++ L K D+++ L+ +D EQ H++ +E+ L E+ + +
Sbjct: 2509 EVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL-ELRNLTVELEQ 2567
Query: 1532 DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTS 1591
Q L K L + L+ LQ + E E E+ K + +EK+ +++T+
Sbjct: 2568 KIQVLQSKNASLQDTLEVLQSSYKNLE----------NELELTKMDKMSFVEKV-NKMTA 2616
Query: 1592 QQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
++ E+ + E+H M Q A+LQE L EK E++ LLEE
Sbjct: 2617 KETEL----------QREMH----EMAQKTAELQEELS------GEKNRLAGELQLLLEE 2656
Query: 1652 LSFQKG---ELNVQISERKTQLTLI-KQEIEKE-EENLQVVLRQMSKHKTELKNILDMLQ 1706
+ K EL ++ SE K L + K ++EKE + ++ Q+ H+ E K+ L
Sbjct: 2657 IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH--QALL 2714
Query: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766
L+ ++ +++Q + +L + + +KLE++ L+ ++ ++ Q+LE K+
Sbjct: 2715 LDTNKQYEVEIQTYR--EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772
Query: 1767 E-------IERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK- 1818
+ ++ E+ Q ++ L K + L+E+ +I +K+L+Q L AA+E K
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQ----LQAAQEKQKT 2828
Query: 1819 --MEQSNLEKLELNVRKLQQELDQLNRDK---LSLHNDISAMQQQLQEKREAVNSLQEEL 1873
+ + +++L +++L++ L++ ++ L + + ++L++ +E + + L
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
Query: 1874 ANVQDHLNLAKQD 1886
+ Q +KQD
Sbjct: 2889 CSQQ-----SKQD 2896
Score = 103 bits (256), Expect = 3e-21
Identities = 188/956 (19%), Positives = 402/956 (42%), Gaps = 129/956 (13%)
Query: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
++ E + + + + E+ EE+ R +R + E ++K++ T+ L++ KN +
Sbjct: 376 QNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV- 434
Query: 308 KSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367
+A L K + +K L E KQK +A Q E EL + K E
Sbjct: 435 ----LQAELDKLT--SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488
Query: 368 ---LNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
++ + E+ E I + + FA E +++Q ++ ++ +
Sbjct: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
Query: 425 DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLK 484
+ + L L + D EK+ +Q L + IE+ ++ + +E K L A++LK
Sbjct: 549 NSLTLE---KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 485 KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK--------------- 529
K Y++L L + + E L QME +K+ + K
Sbjct: 606 KKE-------YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
Query: 530 ----------QKEIKDLQIAI----DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLE 575
+ + ++L + I + LDSK + K +Q+ + ++++Q+
Sbjct: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK-- 716
Query: 576 SRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK-----DLEGVISGLQEYLGTIKG 630
++ + + ++ T +++DLE +L Q+ +NE + K DL L++ L +
Sbjct: 717 -EIENMCLKTSQLTGQVEDLEHKL---QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772
Query: 631 QATQAQNECRKLR--DEKETLLQRLTEV-------EQERDQLEIVA----MDAENMRKEL 677
++ R L D++ + + ER + + A ++ ++ +
Sbjct: 773 SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832
Query: 678 AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
LE +L+ Q ++N+ LQ+ +L + E+E NL AE E R+++L++
Sbjct: 833 DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEE--NLMKAEQMHQSFVAETSQRISKLQE 890
Query: 738 --SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNH 795
SA Q + + AL+N + Q +K + A+++ L+ N+LL+ LK+ Q
Sbjct: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETE---QAEIQELKKSNHLLEDSLKELQ-- 945
Query: 796 LNHVVDGLVRPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARS 854
+ E ++ E+ + L E+ + + L + A L ++ ++ +S
Sbjct: 946 --------LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKS 997
Query: 855 KWERDEAQVRERKLQE-EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQME 913
+ + RE+ + E +QEKL Q CE A + ++ A Q+
Sbjct: 998 ESFANYIDEREKSISELSDQYKQEKLI-----LLQRCEETGNAYEDLSQKYKAA--QEKN 1050
Query: 914 NEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLD 973
+++ L + E L + + E ++ KE + +E K + ++Q + L+
Sbjct: 1051 SKLECL------LNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE 1104
Query: 974 KELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSR--KAAQ 1031
+ L+ + + + +E K ++ +L K+ +E + LQE E+ + K
Sbjct: 1105 TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKH 1164
Query: 1032 AARDLTRAEAEIELLQNLLRQKGE---------QFRLEMEKTGVGTGANSQVLEIEKL-- 1080
++L E E ++N ++++ Q LE+++ + + N+Q++++E +
Sbjct: 1165 ECQNL-----ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS-YNAQLVQLEAMLR 1218
Query: 1081 NETMERQRTEIAR--LQNVLD-LTGSDNKGGFENV-LEEIAELRR-EVSYQNDYIS 1131
N+ ++ Q +E + LQ+ L + G +++ +EI+ L+ E+ + YIS
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS 1274
Score = 98.2 bits (243), Expect = 8e-20
Identities = 223/1147 (19%), Positives = 440/1147 (38%), Gaps = 168/1147 (14%)
Query: 1313 CNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDL------ 1366
CN +LE + L+ L + R ++SEKE E L H + +
Sbjct: 1188 CNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLET 1247
Query: 1367 --LQEKKSLE------CEVEELHRTV------QKRQQQKDFIDGNVESLMTEL-EIEKSL 1411
LQ+ +S E CE++ + + Q + ++++ M +L E+EK
Sbjct: 1248 SNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC 1307
Query: 1412 K----HHEDIVDEI-----ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEK 1462
+ ++V E+ ECI T R E +LL E + + VE
Sbjct: 1308 EILQAEKYELVTELNDSRSECITAT----RKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363
Query: 1463 FTDAK------------RSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQ 1510
+ + L + E L +E ++ + ++ SLQ++ K L
Sbjct: 1364 IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHD 1423
Query: 1511 HKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK---------LQKDIEMAERNE 1561
+ + E+ V + ++ LS +L K L + + +
Sbjct: 1424 QHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPD 1483
Query: 1562 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK 1621
L L +S RA LE+ E AV Q + LQ + K
Sbjct: 1484 SSSLSSLGDSSFY----RALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRK 1539
Query: 1622 ADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKG--------ELNVQISERKTQLTLI 1673
+ A G E+ C R+ LEE +G EL +S + +L +
Sbjct: 1540 -ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL 1598
Query: 1674 KQEIEKEEENLQ-----VVLRQMSKHKTELKNILDM---LQLENHELQGLKLQHDQRVSE 1725
+++ E E Q V L SK E K + L++ +LQGL L +
Sbjct: 1599 RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658
Query: 1726 LEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR-----EIERMTAESRALQS 1780
+ + E ++ ++ Q+ ++D + +IE++T E+ A++
Sbjct: 1659 DTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKIT-ETGAVKP 1717
Query: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRV--LAAAEENSKM------EQSNLEKLELNVR 1832
EC ++ D + +K ++ + L+ + N+ + Q ++ L+L V+
Sbjct: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777
Query: 1833 KLQQE--------------LDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE------- 1871
+ E ++ L + L + + + QL K EA L++
Sbjct: 1778 ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKK 1837
Query: 1872 ---ELANVQDHLNLAKQDLLHTTK-----HQDVLLSEQTRLQKDISE--------WANRF 1915
+L+ ++ + Q+LL + + D+ + ++DI + W RF
Sbjct: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF 1897
Query: 1916 EDCQKEEETKQQQLQVLQNE--IEENKLKLVQQEMMFQRLQKERESEESK---LETSKVT 1970
D + E + + +++E E L++VQ E + L+K+ E+++ LE
Sbjct: 1898 LDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC--LEKDNENKQKVIVCLEEELSV 1955
Query: 1971 LKEQQHQLEKELTDQKSK---LDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
+ +++QL EL K LDQ+ K+ +E+ + L+ + C + ++
Sbjct: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKM---KEKTQELESHQSECLHCIQVAEAEVKEK 2012
Query: 2028 SEREQQLVEKSGELLA----LQKEADSMRADFSLLRNQFLTERKKAEKQVASL---KEAL 2080
+E Q L ELL LQ++ S+ D L + + E Q+A L KE L
Sbjct: 2013 TELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS----LTKCELENQIAQLNKEKELL 2068
Query: 2081 KIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM 2140
+ L+ L E E + K +E + E A RL ++ ++K
Sbjct: 2069 VKESESLQARLSESDYEKLNVSK---ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 2141 ANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGEL 2200
+ E++Q+ I++ ++ + E D ++ ++NL + L + E ++ EN + E+
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERE-NDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 2201 ESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE------DRLKAQLRH 2254
E+LK + L ++ ++ E L ++++ ++ D+L + +
Sbjct: 2185 ETLKTQIE------EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKS 2238
Query: 2255 CMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQ-LESSLTEDSQ 2313
+ ++ + I+ K +++ + L+ Q+ L E V + D + Q L+ + E+ Q
Sbjct: 2239 LLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298
Query: 2314 LGQNQEK 2320
L + EK
Sbjct: 2299 LRNSIEK 2305
Score = 96.3 bits (238), Expect = 3e-19
Identities = 137/652 (21%), Positives = 290/652 (44%), Gaps = 66/652 (10%)
Query: 1649 LEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE 1708
++EL Q +L + +R+ QL ++ ++K+++ ++ + + K E + ++++ E
Sbjct: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC--E 77
Query: 1709 NHELQGLKLQHDQRVSELEKTQVAVLEEKL-----ELENLQQISQQQKGEIEWQKQLLER 1763
+ E K+ H+ +V E +QV E +L ++E L+Q ++ K E+E +Q +
Sbjct: 78 SLEKTKQKISHELQVKE---SQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQS 134
Query: 1764 DKREIERMTAESRALQSCV---ECLSKEK-EDLQEKC--DIWEKKLAQTK-RVLAAAEEN 1816
+ + + + + S K EDL+EK ++ E+K + + + L A + +
Sbjct: 135 ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKAS 194
Query: 1817 SKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKRE---AVNSLQEEL 1873
+ Q+ + ++ + + ++K H +S+ Q+ +R+ + S ++E+
Sbjct: 195 QTLPQATMNHRDIARHQASSSVFSWQQEKTPSH--LSSNSQRTPIRRDFSASYFSGEQEV 252
Query: 1874 ANVQDHLNLAKQDL------LHTTKH-QDVLLSEQTRLQKDISEWANRFEDCQKEEETKQ 1926
+ L + K+D ++ H D L ++ L+ I+E R + +KE + +
Sbjct: 253 TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
Query: 1927 QQLQVLQNEIEENKLKLVQQEMMFQRLQKE---RESEESKLETSKVTLKEQQHQLEKELT 1983
+ Q LQ ++E+ K++L+++E + + + E ++ + T L+++ +L ++L+
Sbjct: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
Query: 1984 DQKSKLDQV-LSKVLAAEERVRTLQEE----ERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
Q+ + S +E+ + QEE +R ++L++ Q K +L++ QQ
Sbjct: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
LQ E D + + L N L E K+ + +A +I+ ++L +++ E K+EN
Sbjct: 433 N---VLQAELDKLTSVKQQLENN-LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488
Query: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ----KDLERR--QME 2152
+ ++ + + + LNQ Q E+K + +Q +DL+ + Q E
Sbjct: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
Query: 2153 ISDAMRTLKSEVKD-------------EIRTSLKNLNQFLPELPADLEAILERNENLEGE 2199
S + LK V D + ++ LN L + + +A+L E + E
Sbjct: 549 NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
Query: 2200 LESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ 2251
E LKE EKL + E L+ K+ H E LK Q
Sbjct: 609 YEELKEEKTLFSCWKSENEKL------LTQMESEKENLQSKINHLETCLKTQ 654
Score = 85.9 bits (211), Expect = 4e-16
Identities = 122/637 (19%), Positives = 279/637 (43%), Gaps = 73/637 (11%)
Query: 1713 QGLKLQHDQRVSELEKTQVAVLEEK----LELENLQQISQQQKGEIEWQKQLLERDKREI 1768
+GL + Q++ ELE + +EK +L++L+ Q+QK ++E +K KRE
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69
Query: 1769 ERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE 1828
+R+ +L+ + +S E + + + + E +L K+ + E+ K +S LE+ +
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Query: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQ----QQLQEKREAVNSLQEELANVQDHLNL-- 1882
+ L+ N + ++ Q + ++ +E N EE ++ +
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
Query: 1883 ---AKQDLLHTT-KHQDVLL----------------------SEQTRLQKDISEWANRFE 1916
A Q L T H+D+ S++T +++D S A+ F
Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS--ASYFS 247
Query: 1917 DCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQH 1976
++E + LQ+ + + + + +L+ + + +K+ +++ L+ Q H
Sbjct: 248 G-EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKI--NELELRLQGH 304
Query: 1977 QLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVE 2036
EKE+ Q +K ++ ++ + +V +++ EK L++ + +L Q +
Sbjct: 305 --EKEMKGQVNKFQEL--QLQLEKAKVELIEK--------EKVLNKCRDELVRTTAQYDQ 352
Query: 2037 KSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQ 2096
S + AL+++ + D S +R+ AE SL++ +K + + ++ L Q++
Sbjct: 353 ASTKYTALEQKLKKLTEDLS-------CQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 2097 ENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDA 2156
+ +E ++ ++A+ + L + T +K+Q+ N +LE + ++ A
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLEN--NLEEFKQKLCRA 463
Query: 2157 MRTLK-SEVKD-EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEG 2214
+ + S++K+ E+R S++ + + L + E +LE EL+++K+ L + N
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 2215 PFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
+ N SQ ++ + L+EK+ +E+ L + + L K + ++ L
Sbjct: 524 EEMKAKNTSQETMLRD------LQEKINQQENSLTLEK---LKLAVADLEKQRDCSQDLL 574
Query: 2275 HSLRRQVDALGELVTSTSADSASSPSLSQLESSLTED 2311
++ L + ++ T +S + S +L+ E+
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Score = 75.9 bits (185), Expect = 4e-13
Identities = 152/759 (20%), Positives = 300/759 (39%), Gaps = 139/759 (18%)
Query: 405 IDSAQAVQIKKMEPDEQLRNDHMNLRGHTP---------------LDTQLEDKEKKISAA 449
+DS +A K+ + E + + NL+ + +L+ KE +++
Sbjct: 41 LDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQ 100
Query: 450 QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKI------------------SEAGK 491
+ +L+ +IEK EQ++ R E ++ ++A Q + S+
Sbjct: 101 EGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS 160
Query: 492 DLLYKQLSGRL--QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL--QIAIDSLDS-- 545
Y+ L + ++ + R EA LQ +K Q + +D+ A S+ S
Sbjct: 161 GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220
Query: 546 --KDPKHSHMKAQK------------SGKEQ---------------------------QL 564
K P H +Q+ SG+++ L
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 565 DIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK--DLEGVISGLQ 622
D + Q Q+L ++++E+ R+ +E+K + E Q+ +A + + E V++ +
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 623 EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
+ L Q QA + L + + L + L+ Q + ++ +++ E E
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC------SLEQKIKEKEK 394
Query: 683 ALQEQ-HEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ 741
QE+ S Q + +A L L N L+ EL+K+T + Q L+
Sbjct: 395 EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQ----QLE 450
Query: 742 AELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQ-------------- 787
LE+ +Q L A Q S+ KE +EL ++ ++ +NNLLK
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKE---NELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 788 QLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ- 846
+LK+ + LN + + + + R L+ + + L ++ADL+KQ
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 847 --FSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQ 904
++L + + ++ + K ++E L ++E+ + E + + K +
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE--KTLFSCWKSE 625
Query: 905 HEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADE-------EKERILAQLRELEKK 957
+E + QME+E LQ + +E ++ E +E ++E + ++R L
Sbjct: 626 NEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH-- 683
Query: 958 KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQ--ER 1015
+ D+KS ++ E +KL A + AE + K Q K + +K +Q +
Sbjct: 684 -NVLDSKS------VEVETQKL----AYMELQQKAEFSDQKHQ-KEIENMCLKTSQLTGQ 731
Query: 1016 AEELQ-EAERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
E+L+ + + S + R AE E L++LL+ K
Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
Score = 75.1 bits (183), Expect = 7e-13
Identities = 137/645 (21%), Positives = 264/645 (40%), Gaps = 98/645 (15%)
Query: 504 LVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQ 563
L + Q+ +LE Q++K K KE + Q +DSL++ K + +
Sbjct: 12 LPTRALQKIQELEGQLDKLK-------KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQE 623
L N++ ++ L++ +I+ E ++K+ + EGQ+ + + + LE + +
Sbjct: 65 LKRENQRLMEICESLEKTKQKISHEL-QVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 624 YLGTIKGQATQAQ---NECR-------------------KLRDEKETLLQRLTEVEQERD 661
L + A A N C K D KE + + E++R
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE--ERKRL 181
Query: 662 QLEIVAMDAENMRKELAELESALQE--QHEVNASL-----QQTQGDLSAYEAELEARLNL 714
+ E+ A+ A+ + L + ++ +H+ ++S+ ++T LS+ R
Sbjct: 182 EAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIR--- 238
Query: 715 RDAEANQLKEELEKVTRLTQLEQSALQA---------------ELEKERQALKNALGKAQ 759
RD A+ E E + L+ A +L+ + Q L+N + + +
Sbjct: 239 RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
Query: 760 FS-EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRP----EEVAARVD 814
+ E+E K + LQ K +L + + LN D LVR ++ + +
Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 815 ELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMAL 874
L +KLK T +++ Q+Q +E AR E+ + + +E++ QEE++
Sbjct: 359 ALEQKLKKLTEDLS--------------CQRQNAE-SARCSLEQ-KIKEKEKEFQEELSR 402
Query: 875 QQEKLATGQEEFRQACERALEARMNFDKRQH---EARIQQMENEIHYLQENLKSMEEIQG 931
QQ T +E Q R L + K H +A + ++ + L+ NL+ ++
Sbjct: 403 QQRSFQTLDQECIQMKAR-LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLC 461
Query: 932 LTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQE---QVFGLDKELKKLKKAVATSDK 988
+ Q + ++ + + E++K+ L + S++ +V L+ ELK +K+ + S
Sbjct: 462 RAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 989 LATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQN 1048
A Q L KINQ QE K A DL E + + Q+
Sbjct: 522 FAEEMKAKNTSQETMLRDLQEKINQ------QENSLTLEKLKLAVADL---EKQRDCSQD 572
Query: 1049 LLRQKG---EQFRLEMEKTGVGTGANSQVLEIEKLN-ETMERQRT 1089
LL+++ EQ ++ KT + A LE++K E ++ ++T
Sbjct: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Score = 73.6 bits (179), Expect = 2e-12
Identities = 149/715 (20%), Positives = 290/715 (40%), Gaps = 100/715 (13%)
Query: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ-LKKISEA---G 490
L+ QL+ +K+ Q +L L ++K +Q++ E L+ Q L +I E+
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 491 KDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLD-SKDPK 549
K + +L + VN + + Q+EK +QE+ + E++ Q A S D S +P
Sbjct: 83 KQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
Query: 550 HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEA 609
++ K + +Y+ L+ + ++ + + E+K L+ + +
Sbjct: 143 NTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATM 202
Query: 610 LKKDL------EGVISGLQEYLGTIKGQATQAQNECRK--LRDEKETLLQRLTEVEQERD 661
+D+ V S QE K + + N R RD + EV R
Sbjct: 203 NHRDIARHQASSSVFSWQQE-----KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 662 QLEIVAMDA---------------------ENMRKELAELESALQ-EQHEVNASLQQTQG 699
L+I DA + +R ++ ELE LQ + E+ + + Q
Sbjct: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ- 316
Query: 700 DLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ-AELEKERQALKNALGKA 758
+L + + L ++ N+ ++EL + T Q +Q++ + LE++ + L L
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTT--AQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 759 QFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRR 818
+ + E + + E K K + L +QQ + FQ + R + + +
Sbjct: 375 RQNAESARCSLEQKIKEKEKEFQEELSRQQ-RSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 819 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQ---EEMALQ 875
L+ ++ + + L + ++F + L R++ +Q++E +L+ EEM +
Sbjct: 434 VLQAELDKLT------SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 876 QEKLAT-GQEEFRQAC---------ERALEARMNFDKRQHEARIQQMENEIHYLQENLKS 925
L + +++ R+ C ++ L NF + +A+ E + LQE +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF-AEEMKAKNTSQETMLRDLQEKINQ 546
Query: 926 MEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVAT 985
E L L+L AD EK+R +Q +L KK++ + +++ +KE K L A
Sbjct: 547 QENSLTLEKLKLAVADLEKQRDCSQ--DLLKKREHHIEQLNDKLSKTEKESKALLSA--- 601
Query: 986 SDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER-FSRKAAQAARDLTRAEAEIE 1044
+++ ++ EEL+E + FS ++ + LT+ E+E E
Sbjct: 602 -----------------------LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE 638
Query: 1045 LLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLD 1099
LQ+ + + + K+ N +V +E E + EI L NVLD
Sbjct: 639 NLQSKINHLETCLKTQQIKS---HEYNERVRTLEMDRENLS---VEIRNLHNVLD 687
Score = 71.2 bits (173), Expect = 1e-11
Identities = 163/780 (20%), Positives = 325/780 (41%), Gaps = 81/780 (10%)
Query: 244 LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ 303
L +LE+ E + D+ E E+ ++E+++ LE + E + L + +E+ +
Sbjct: 903 LSALENKEKELQLLNDKVET-EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI 961
Query: 304 DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
LNK EE + + +E+ + LN + L QK+ ++ + EL+
Sbjct: 962 ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE 1021
Query: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLR 423
K L E A ++ K+ ++N E + + + +K E EQL+
Sbjct: 1022 KLILL----QRCEETGNAYEDLSQKYKAAQEKNS-KLECLLNECTSLCENRKNEL-EQLK 1075
Query: 424 NDHMNLRGHTPLDTQL---EDKEKKI-----SAAQTRLSELHDEIEKAEQQILRATEEFK 475
+ H T+L E++ + + + Q SE+ D ++ + +E
Sbjct: 1076 EAF--AKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIM 1133
Query: 476 QLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQ------MEKQKQEIAGK 529
L+E + K+ + DLL Q + +L V K + E +LE + E++ +
Sbjct: 1134 TLKE--EQNKMQKEVNDLL--QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCN 1189
Query: 530 QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
K DL++ SLDS + + ++A KE +L K+ + L+ L I + ET
Sbjct: 1190 FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL--ET 1247
Query: 590 EEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649
++D++ Q G KD E I ++Y+ + + +QN+ L+ +T
Sbjct: 1248 SNLQDMQSQEISG--------LKDCE--IDAEEKYISG-PHELSTSQNDNAHLQCSLQTT 1296
Query: 650 LQRLTEVEQ-----ERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAY 704
+ +L E+E+ + ++ E+V ++ + + +E ++ ++ D
Sbjct: 1297 MNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLL 1356
Query: 705 EAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK 764
EL ++ E + E V+ L L++S E L + + F+E +
Sbjct: 1357 HGELVE--DIPGGEFGEQPNEQHPVS-LAPLDESN-----SYEHLTLSDKEVQMHFAELQ 1408
Query: 765 EQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV-VDGLVRPEEVAARVDELRRKLKLG 823
E+ S L ++ K L D + + ++ + Q +++ + + LV + +L ++++LG
Sbjct: 1409 EKFLS-LQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLG 1467
Query: 824 TGEMNIHS------PSDVLGKSLAD------LQKQFSEILARSKWE----RDEAQVRE-- 865
E + S P SL D L +Q ++ S E ++ V E
Sbjct: 1468 LEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVF 1527
Query: 866 -RKLQEEMALQQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
LQEE ++E A G EE CE ++ +++ I + EI L++
Sbjct: 1528 CSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK-NKEIQELEQ 1586
Query: 922 NLKS-MEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLK 980
L S +E+ L L E ++ ++++ + E+E K E K Q + L+ E+ +L+
Sbjct: 1587 LLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAE--KKQTEQLSLELEVARLQ 1644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,398,281
Number of Sequences: 37866
Number of extensions: 4313798
Number of successful extensions: 79412
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 828
Number of HSP's successfully gapped in prelim test: 2010
Number of HSP's that attempted gapping in prelim test: 21452
Number of HSP's gapped (non-prelim): 24367
length of query: 2325
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2206
effective length of database: 13,741,464
effective search space: 30313669584
effective search space used: 30313669584
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.