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Search of human proteins with 82880648
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
(800 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 1635 0.0
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 673 0.0
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 228 2e-59
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 225 1e-58
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 223 4e-58
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 218 1e-56
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 213 6e-55
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 206 9e-53
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 165 1e-40
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 165 1e-40
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 165 1e-40
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 165 1e-40
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 157 5e-38
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 157 5e-38
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 157 5e-38
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 157 5e-38
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 154 3e-37
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 154 3e-37
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 151 3e-36
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 143 7e-34
gi|4503787 fyn-related kinase [Homo sapiens] 143 7e-34
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 141 2e-33
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 141 2e-33
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 140 5e-33
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 140 5e-33
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 135 1e-31
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 135 1e-31
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 134 3e-31
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 132 1e-30
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 132 1e-30
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 1635 bits (4234), Expect = 0.0
Identities = 800/800 (100%), Positives = 800/800 (100%)
Query: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
Sbjct: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
Query: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
Sbjct: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240
Query: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
Sbjct: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300
Query: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE 360
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
Sbjct: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE 360
Query: 361 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL 420
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
Sbjct: 361 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL 420
Query: 421 IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT 480
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
Sbjct: 421 IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT 480
Query: 481 NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ 540
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
Sbjct: 481 NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ 540
Query: 541 DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP 600
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
Sbjct: 541 DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP 600
Query: 601 FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS 660
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
Sbjct: 601 FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS 660
Query: 661 SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS 720
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
Sbjct: 661 SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS 720
Query: 721 ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP 780
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
Sbjct: 721 ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP 780
Query: 781 SPAKTNKERARGDHRGWRNF 800
SPAKTNKERARGDHRGWRNF
Sbjct: 781 SPAKTNKERARGDHRGWRNF 800
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 673 bits (1737), Expect = 0.0
Identities = 331/331 (100%), Positives = 331/331 (100%)
Query: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
Sbjct: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
Query: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
Sbjct: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240
Query: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
Sbjct: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300
Query: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLL 331
LSFKEQELKERERRLKMWEQKLTEQSNTPLL
Sbjct: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLL 331
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 228 bits (580), Expect = 2e-59
Identities = 135/344 (39%), Positives = 195/344 (56%), Gaps = 32/344 (9%)
Query: 9 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKK------------LLKIEKEAEI 56
++I F +L E G G FG VYRA WI EVAVK + + +EA++
Sbjct: 137 LEIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQEAKL 194
Query: 57 LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 116
++L H NII GV L+ PN +V E+A G L ++ R + D ++ WA +A+
Sbjct: 195 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIAR 251
Query: 117 GMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVG 168
GM+YLH EA V +IHRDLKS N++I ++ +LKI DFG +R + TT MS G
Sbjct: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 311
Query: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIP 228
T+ WMAPEVI++ S+ D +SYGV+LWE+LT EVPF+G++GL VA+ V L IP
Sbjct: 312 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 371
Query: 229 SSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIE 288
S+CP FA+L+ CW D RPSF I+ L ++ +SF + W+ EI+
Sbjct: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQ 431
Query: 289 ATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
++L+ E++L E+EL K +E L+ EQ+L E+
Sbjct: 432 EMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAER 475
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 225 bits (573), Expect = 1e-58
Identities = 134/343 (39%), Positives = 191/343 (55%), Gaps = 32/343 (9%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL------------KIEKEAEIL 57
+I F +LQ E G G FG VYRA W + +EVAVK ++ +EA +
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALW--RGEEVAVKAARLDPEKDPAVTAEQVCQEARLF 149
Query: 58 SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117
L H NII G L PP+ +V EYA G+L + R + ++ WA VA+G
Sbjct: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARG 206
Query: 118 MHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVGT 169
M+YLH +APV +IHRDLKS N++I AD VLKI DFG +R + TT MS GT
Sbjct: 207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT 266
Query: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPS 229
+ WMAPEVI+ S++ D +S+GV+LWE+LT EVP++ ++ L VA+ V L IPS
Sbjct: 267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPS 326
Query: 230 SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEA 289
+CP FA LL +CW+ D RP F I+ LE + SF + +W+ EI+
Sbjct: 327 TCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQH 386
Query: 290 TLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
+ L+ E++L +E+EL + +E +L+ EQ+L E+
Sbjct: 387 MFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAER 429
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 223 bits (569), Expect = 4e-58
Identities = 133/359 (37%), Positives = 198/359 (55%), Gaps = 41/359 (11%)
Query: 6 ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKE 53
+S V + F+ L+ E G G FG VYRA W Q +EVAVK + + +E
Sbjct: 114 SSPVHVAFERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRRE 171
Query: 54 AEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS------------NRSEE 101
A + ++L H NII+ GV L+ P+ +V E+A G+L + + R+
Sbjct: 172 ARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARR 231
Query: 102 MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFG 153
+ ++ WA +A+GM YLH EA V ++HRDLKS N+++ + LKI DFG
Sbjct: 232 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 291
Query: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213
+R + TT MS GT+ WMAPEVI+S S+ D +SYGV+LWE+LT EVP++G++GL
Sbjct: 292 LAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 351
Query: 214 VAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKC 273
VA+ V L IPS+CP FA+L+ +CW+ D RPSF I+ L ++
Sbjct: 352 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQ 411
Query: 274 NSFLHNKAEWRCEIEATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
SF + +W+ EI+ + L+ E++L +E+EL K +E LK EQ+L E+
Sbjct: 412 ESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAER 470
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 218 bits (556), Expect = 1e-56
Identities = 131/352 (37%), Positives = 192/352 (54%), Gaps = 37/352 (10%)
Query: 13 FDDLQFFENCGGGSFGSVYRAKWISQ-----------DKEVAVKKLLKIEKEAEILSVLS 61
F +L+ E G G FG VYR W + D++++V + +EA + ++L+
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE-SVRQEARLFAMLA 172
Query: 62 HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121
H NII V LE PN +V EYA+ G L + R + ++ WA +A+GMHYL
Sbjct: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229
Query: 122 HMEAPVKVIHRDLKSRNVV----IAADGV----LKICDFGASRFHNHTTHMSLVGTFPWM 173
H EA V VIHRDLKS N++ I +D + LKI DFG +R + TT MS GT+ WM
Sbjct: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
Query: 174 APEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPR 233
APEVI++ S+ D +S+GV+LWE+LT EVP++G++ L VA+ V L IPS+CP
Sbjct: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349
Query: 234 SFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER 293
FA+L+ CW D +RP F I+ LE++ +SF + W+ EI+ +
Sbjct: 350 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDE 409
Query: 294 LKKLERDLSFKEQE--------------LKERERRLKMWEQKLTEQSNTPLL 331
L+ E++L +E+E L+ RE L WE ++ E+ T LL
Sbjct: 410 LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLL 461
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 213 bits (542), Expect = 6e-55
Identities = 122/307 (39%), Positives = 184/307 (59%), Gaps = 12/307 (3%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEI--LSVLSHRNIIQ 67
++ F+++ + G G+ G+V+ ++ +EVAVKK+ + KE +I L L H NII
Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRDL-KETDIKHLRKLKHPNIIT 175
Query: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
F GV + P Y I+ E+ + G LY+ + + R + ++ W+ +A GM+YLH+
Sbjct: 176 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL--LVDWSMGIAGGMNYLHLH--- 230
Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
K+IHRDLKS N++I D V+KI DFG S+ + +T MS GT WMAPEVI++ PVSE
Sbjct: 231 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 290
Query: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
D +S+GVVLWE+LT E+P+K ++ + W V + L +PSSCP F LL QCW +
Sbjct: 291 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSK 350
Query: 247 AKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQ 306
+ RPSF+QI+ L+ S D L ++ ++AEWR E++ E++K L E+
Sbjct: 351 PRNRPSFRQILLHLDIASADV-LSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEE 409
Query: 307 ELKERER 313
EL R R
Sbjct: 410 ELVMRRR 416
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 206 bits (523), Expect = 9e-53
Identities = 114/306 (37%), Positives = 182/306 (59%), Gaps = 10/306 (3%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68
++ F+++ + G G+ G+V+ K+ ++ EVA+KK+ + E + + L L H NII F
Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLRKLKHPNIIAF 219
Query: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128
GV + P Y I+ EY + G LY+ + + R + ++ W+T +A GM+YLH+ K
Sbjct: 220 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLH---K 274
Query: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187
+IHRDLKS NV++ +KI DFG S+ + +T MS GT WMAPEVI++ PVSE
Sbjct: 275 IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 334
Query: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247
D +S+GVVLWE+LT E+P+K ++ + W V + L +PS+CP F L+ Q W++
Sbjct: 335 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP 394
Query: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307
+ RPSF+Q + L+ S D L ++ ++AEWR E++ E++K + ++E
Sbjct: 395 RNRPSFRQTLMHLDIASADV-LATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEE 453
Query: 308 LKERER 313
L R R
Sbjct: 454 LIRRRR 459
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 165 bits (418), Expect = 1e-40
Identities = 114/361 (31%), Positives = 183/361 (50%), Gaps = 45/361 (12%)
Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
+F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS +
Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
+H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+
Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
+ SE CD +S+G++LWE++TR PF + G ++ W V R + + P+
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
L+ +CW D +RPS ++I+ I+ E SN S
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
D ++ NK++ E + AT + +K+LE L + + + RL + + + +
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
Query: 329 P 329
P
Sbjct: 380 P 380
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 165 bits (418), Expect = 1e-40
Identities = 114/361 (31%), Positives = 183/361 (50%), Gaps = 45/361 (12%)
Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
+F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS +
Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
+H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+
Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
+ SE CD +S+G++LWE++TR PF + G ++ W V R + + P+
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
L+ +CW D +RPS ++I+ I+ E SN S
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
D ++ NK++ E + AT + +K+LE L + + + RL + + + +
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
Query: 329 P 329
P
Sbjct: 380 P 380
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 165 bits (418), Expect = 1e-40
Identities = 114/361 (31%), Positives = 183/361 (50%), Gaps = 45/361 (12%)
Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
+F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS +
Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
+H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+
Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
+ SE CD +S+G++LWE++TR PF + G ++ W V R + + P+
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
L+ +CW D +RPS ++I+ I+ E SN S
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
D ++ NK++ E + AT + +K+LE L + + + RL + + + +
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
Query: 329 P 329
P
Sbjct: 380 P 380
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 165 bits (418), Expect = 1e-40
Identities = 114/361 (31%), Positives = 183/361 (50%), Gaps = 45/361 (12%)
Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
+F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS +
Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
+H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+
Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
+ SE CD +S+G++LWE++TR PF + G ++ W V R + + P+
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
L+ +CW D +RPS ++I+ I+ E SN S
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
D ++ NK++ E + AT + +K+LE L + + + RL + + + +
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
Query: 329 P 329
P
Sbjct: 380 P 380
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 157 bits (396), Expect = 5e-38
Identities = 111/336 (33%), Positives = 169/336 (50%), Gaps = 20/336 (5%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331
Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL +
Sbjct: 332 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 388
Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE +
Sbjct: 389 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 447
Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C
Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLS 302
W+ RPSF + E+M +D+S+ ++ L +A + L RL L
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL-GRAASSSSVVPYLPRLPILPSKTR 565
Query: 303 FKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGA 338
+++++ +E Q TE S + L P F GA
Sbjct: 566 TLKKQVENKEN--IEGAQDATENSASSLAPGFIRGA 599
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 157 bits (396), Expect = 5e-38
Identities = 111/336 (33%), Positives = 169/336 (50%), Gaps = 20/336 (5%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 346
Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL +
Sbjct: 347 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 403
Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE +
Sbjct: 404 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 462
Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C
Sbjct: 463 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 521
Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLS 302
W+ RPSF + E+M +D+S+ ++ L +A + L RL L
Sbjct: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL-GRAASSSSVVPYLPRLPILPSKTR 580
Query: 303 FKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGA 338
+++++ +E Q TE S + L P F GA
Sbjct: 581 TLKKQVENKEN--IEGAQDATENSASSLAPGFIRGA 614
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 157 bits (396), Expect = 5e-38
Identities = 111/336 (33%), Positives = 169/336 (50%), Gaps = 20/336 (5%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331
Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL +
Sbjct: 332 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 388
Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE +
Sbjct: 389 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 447
Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C
Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLS 302
W+ RPSF + E+M +D+S+ ++ L +A + L RL L
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL-GRAASSSSVVPYLPRLPILPSKTR 565
Query: 303 FKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGA 338
+++++ +E Q TE S + L P F GA
Sbjct: 566 TLKKQVENKEN--IEGAQDATENSASSLAPGFIRGA 599
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 157 bits (396), Expect = 5e-38
Identities = 111/336 (33%), Positives = 169/336 (50%), Gaps = 20/336 (5%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 251 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 310
Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL +
Sbjct: 311 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 367
Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE +
Sbjct: 368 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 426
Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C
Sbjct: 427 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 485
Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLS 302
W+ RPSF + E+M +D+S+ ++ L +A + L RL L
Sbjct: 486 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL-GRAASSSSVVPYLPRLPILPSKTR 544
Query: 303 FKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGA 338
+++++ +E Q TE S + L P F GA
Sbjct: 545 TLKKQVENKEN--IEGAQDATENSASSLAPGFIRGA 578
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 154 bits (389), Expect = 3e-37
Identities = 88/269 (32%), Positives = 145/269 (53%), Gaps = 15/269 (5%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300
Query: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
GV P + I+TE+ + G+L DY+ +E++ ++ AT ++ M YL +
Sbjct: 301 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--- 357
Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVS 184
IHRDL +RN ++ + ++K+ DFG SR T+ + G FP W APE + S
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
Query: 185 ETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 243
D +++GV+LWE+ T + P+ G++ QV + ++EK+ R+ P CP EL+ CW
Sbjct: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYELMRACW 476
Query: 244 EADAKKRPSFKQIISILESMSNDTSLPDK 272
+ + RPSF +I E+M ++S+ D+
Sbjct: 477 QWNPSDRPSFAEIHQAFETMFQESSISDE 505
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 154 bits (389), Expect = 3e-37
Identities = 88/269 (32%), Positives = 145/269 (53%), Gaps = 15/269 (5%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 319
Query: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
GV P + I+TE+ + G+L DY+ +E++ ++ AT ++ M YL +
Sbjct: 320 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--- 376
Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVS 184
IHRDL +RN ++ + ++K+ DFG SR T+ + G FP W APE + S
Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 436
Query: 185 ETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 243
D +++GV+LWE+ T + P+ G++ QV + ++EK+ R+ P CP EL+ CW
Sbjct: 437 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYELMRACW 495
Query: 244 EADAKKRPSFKQIISILESMSNDTSLPDK 272
+ + RPSF +I E+M ++S+ D+
Sbjct: 496 QWNPSDRPSFAEIHQAFETMFQESSISDE 524
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 151 bits (381), Expect = 3e-36
Identities = 95/269 (35%), Positives = 143/269 (53%), Gaps = 17/269 (6%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q
Sbjct: 266 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 325
Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL +
Sbjct: 326 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 382
Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE +
Sbjct: 383 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 441
Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C
Sbjct: 442 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 500
Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPD 271
W+ RPSF + E+M +D+S+ +
Sbjct: 501 WKWSPADRPSFAETHQAFETMFHDSSISE 529
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 143 bits (360), Expect = 7e-34
Identities = 88/263 (33%), Positives = 137/263 (52%), Gaps = 17/263 (6%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL-------KIEKEAEILSVLSH 62
+I + LQ + G G FG V+ W K VA+K L +EA+I+ L H
Sbjct: 265 EIPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPESFLEEAQIMKKLKH 323
Query: 63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122
++Q Y V+ E P Y IVTEY + GSL D++ + + +++ A VA GM Y+
Sbjct: 324 DKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 382
Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179
+ IHRDL+S N+++ + KI DFG +R + + G FP W APE
Sbjct: 383 R---MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 439
Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238
+ D +S+G++L E++T+ VP+ G+ +V V E+ R+ P CP S EL
Sbjct: 440 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHEL 498
Query: 239 LHQCWEADAKKRPSFKQIISILE 261
+ CW+ D ++RP+F+ + S LE
Sbjct: 499 MIHCWKKDPEERPTFEYLQSFLE 521
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 143 bits (360), Expect = 7e-34
Identities = 91/283 (32%), Positives = 146/283 (51%), Gaps = 21/283 (7%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62
+I + +Q + G G FG V+ W + VAVK L +EA+I+ L H
Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLW-NNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRH 286
Query: 63 RNIIQFYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121
+IQ Y V LE P Y I+TE GSL +Y+ ++ ++ + + A VA GM YL
Sbjct: 287 PKLIQLYAVCTLEDPIY-IITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
Query: 122 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN------HTTHMSLVGTFPWMAP 175
IHRDL +RNV++ + K+ DFG +R + + + W AP
Sbjct: 346 ESR---NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAP 402
Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234
E I+S S D +S+G++L+E++T ++P+ G+ G QV ++ + N RL PS+CP+
Sbjct: 403 EAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQ-NYRLPQPSNCPQQ 461
Query: 235 FAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFL 277
F ++ +CW A+ K+RP+F+ + LE S N+F+
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFI 504
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 141 bits (356), Expect = 2e-33
Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)
Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55
S ++ +++F E G GSFG VY+ + ++K VA+K+ +E
Sbjct: 454 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 511
Query: 56 ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114
IL L+H +IQF G L +P + IVT+Y S GSL+ ++ + +D+ + A DV
Sbjct: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 570
Query: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171
AKGM YLH +IHRDL S N+++ DG + DFG SRF ++ G
Sbjct: 571 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629
Query: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
WMAPEV Q + D +SY + LWE+LT E+PF L+ A + + R I S
Sbjct: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689
Query: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
P+ + LL + W A + RP F +++ LE
Sbjct: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 141 bits (356), Expect = 2e-33
Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)
Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55
S ++ +++F E G GSFG VY+ + ++K VA+K+ +E
Sbjct: 555 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 612
Query: 56 ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114
IL L+H +IQF G L +P + IVT+Y S GSL+ ++ + +D+ + A DV
Sbjct: 613 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 671
Query: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171
AKGM YLH +IHRDL S N+++ DG + DFG SRF ++ G
Sbjct: 672 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730
Query: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
WMAPEV Q + D +SY + LWE+LT E+PF L+ A + + R I S
Sbjct: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790
Query: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
P+ + LL + W A + RP F +++ LE
Sbjct: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 140 bits (353), Expect = 5e-33
Identities = 94/273 (34%), Positives = 142/273 (52%), Gaps = 26/273 (9%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQD-KEVAVK-KLLKIE------------KEAEILSVL 60
DL+ E G GSFG V R +W + K V+V K LK + +E + L
Sbjct: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
HRN+I+ YGV+L PP +VTE A LGSL D + ++ + + + +A VA+GM Y
Sbjct: 185 DHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGY 242
Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFPWMAP 175
L + + IHRDL +RN+++A ++KI DFG R ++ F W AP
Sbjct: 243 LESK---RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299
Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234
E +++ S DT+ +GV LWEM T + P+ GL G Q+ + ++ ERL P CP+
Sbjct: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359
Query: 235 FAELLHQCWEADAKKRPSFKQIIS-ILESMSND 266
++ QCW + RP+F + +LE+ D
Sbjct: 360 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 392
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 140 bits (353), Expect = 5e-33
Identities = 94/273 (34%), Positives = 142/273 (52%), Gaps = 26/273 (9%)
Query: 15 DLQFFENCGGGSFGSVYRAKWISQD-KEVAVK-KLLKIE------------KEAEILSVL 60
DL+ E G GSFG V R +W + K V+V K LK + +E + L
Sbjct: 188 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 247
Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
HRN+I+ YGV+L PP +VTE A LGSL D + ++ + + + +A VA+GM Y
Sbjct: 248 DHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGY 305
Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFPWMAP 175
L + + IHRDL +RN+++A ++KI DFG R ++ F W AP
Sbjct: 306 LESK---RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 362
Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234
E +++ S DT+ +GV LWEM T + P+ GL G Q+ + ++ ERL P CP+
Sbjct: 363 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 422
Query: 235 FAELLHQCWEADAKKRPSFKQIIS-ILESMSND 266
++ QCW + RP+F + +LE+ D
Sbjct: 423 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 455
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 135 bits (341), Expect = 1e-31
Identities = 86/272 (31%), Positives = 146/272 (53%), Gaps = 17/272 (6%)
Query: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 55
SLG ++K +++ + G G FG V KW Q +VAVK + + +EA+
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKMIKEGSMSEDEFFQEAQ 462
Query: 56 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 115
+ LSH +++FYGV + IVTEY S G L +Y+ S+ + ++ ++ DV
Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVC 521
Query: 116 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--W 172
+GM +L + IHRDL +RN ++ D +K+ DFG +R+ ++S VGT FP W
Sbjct: 522 EGMAFLESH---QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKW 578
Query: 173 MAPEVIQSLPVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSC 231
APEV S D +++G+++WE+ + + P+ + QV L V + RL P
Sbjct: 579 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVV-LKVSQGHRLYRPHLA 637
Query: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263
+ ++++ CW +KRP+F+Q++S +E +
Sbjct: 638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 135 bits (341), Expect = 1e-31
Identities = 86/272 (31%), Positives = 146/272 (53%), Gaps = 17/272 (6%)
Query: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 55
SLG ++K +++ + G G FG V KW Q +VAVK + + +EA+
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKMIKEGSMSEDEFFQEAQ 462
Query: 56 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 115
+ LSH +++FYGV + IVTEY S G L +Y+ S+ + ++ ++ DV
Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVC 521
Query: 116 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--W 172
+GM +L + IHRDL +RN ++ D +K+ DFG +R+ ++S VGT FP W
Sbjct: 522 EGMAFLESH---QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKW 578
Query: 173 MAPEVIQSLPVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSC 231
APEV S D +++G+++WE+ + + P+ + QV L V + RL P
Sbjct: 579 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVV-LKVSQGHRLYRPHLA 637
Query: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263
+ ++++ CW +KRP+F+Q++S +E +
Sbjct: 638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 134 bits (337), Expect = 3e-31
Identities = 84/250 (33%), Positives = 130/250 (52%), Gaps = 17/250 (6%)
Query: 23 GGGSFGSVYRAKWISQDKEVAVKKLL-------KIEKEAEILSVLSHRNIIQFYGVILEP 75
G G F V+ W K VA+K L +EA+I+ L H ++Q Y V+ E
Sbjct: 275 GQGCFAEVWLGTWNGNTK-VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE 333
Query: 76 PNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135
P Y IVTEY + GSL D++ + + +++ A VA GM Y+ + IHRDL+
Sbjct: 334 PIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLR 389
Query: 136 SRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVSETCDTYSY 192
S N+++ + KI DFG +R + + G FP W APE + D +S+
Sbjct: 390 SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 449
Query: 193 GVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRP 251
G++L E++T+ VP+ G+ +V V E+ R+ P CP S EL+ CW+ D ++RP
Sbjct: 450 GILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERP 508
Query: 252 SFKQIISILE 261
+F+ + S LE
Sbjct: 509 TFEYLQSFLE 518
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 132 bits (333), Expect = 1e-30
Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62
+I + L+ G G FG V+ W + VA+K L +EA+++ L H
Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322
Query: 63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122
++Q Y V+ E P Y IVTEY S GSL D++ + + + ++ A +A GM Y+
Sbjct: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381
Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179
+ +HRDL++ N+++ + V K+ DFG +R + + G FP W APE
Sbjct: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238
+ D +S+G++L E+ T+ VP+ G+ +V V E+ R+ P CP S +L
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 497
Query: 239 LHQCWEADAKKRPSFKQIISILESMSNDT 267
+ QCW + ++RP+F+ + + LE T
Sbjct: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 132 bits (333), Expect = 1e-30
Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%)
Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62
+I + L+ G G FG V+ W + VA+K L +EA+++ L H
Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322
Query: 63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122
++Q Y V+ E P Y IVTEY S GSL D++ + + + ++ A +A GM Y+
Sbjct: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381
Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179
+ +HRDL++ N+++ + V K+ DFG +R + + G FP W APE
Sbjct: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238
+ D +S+G++L E+ T+ VP+ G+ +V V E+ R+ P CP S +L
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 497
Query: 239 LHQCWEADAKKRPSFKQIISILESMSNDT 267
+ QCW + ++RP+F+ + + LE T
Sbjct: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,862,377
Number of Sequences: 37866
Number of extensions: 1557402
Number of successful extensions: 9149
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 641
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 5917
Number of HSP's gapped (non-prelim): 1666
length of query: 800
length of database: 18,247,518
effective HSP length: 110
effective length of query: 690
effective length of database: 14,082,258
effective search space: 9716758020
effective search space used: 9716758020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.