Search of human proteins with 7669520

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
         (462 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]                  929   0.0  
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]               887   0.0  
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]              853   0.0  
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]            811   0.0  
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]           811   0.0  
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]            808   0.0  
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]           743   0.0  
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]           700   0.0  
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]           662   0.0  
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]               606   e-173
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]            431   e-121
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]            418   e-117
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]           375   e-104
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]           350   2e-96
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]           337   1e-92
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]                 286   4e-77
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                      275   5e-74
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                      270   2e-72
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                      270   3e-72
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                      266   3e-71
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]                   109   6e-24
gi|66730481 neuregulin 3 [Homo sapiens]                                91   2e-18
gi|110349719 titin isoform N2-A [Homo sapiens]                         56   6e-08
gi|110349717 titin isoform novex-2 [Homo sapiens]                      56   6e-08
gi|110349713 titin isoform novex-1 [Homo sapiens]                      56   6e-08
gi|110349715 titin isoform N2-B [Homo sapiens]                         56   6e-08
gi|93102361 palladin [Homo sapiens]                                    54   2e-07
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             51   2e-06
gi|221316757 neurotrimin isoform 3 [Homo sapiens]                      51   3e-06
gi|45594240 limbic system-associated membrane protein [Homo sapi...    51   3e-06

>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
          Length = 462

 Score =  929 bits (2401), Expect = 0.0
 Identities = 462/462 (100%), Positives = 462/462 (100%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240

Query: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300
           KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
Sbjct: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300

Query: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360
           PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
Sbjct: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360

Query: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420
           ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
Sbjct: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420

Query: 421 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 462
           SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
Sbjct: 421 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 462


>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
          Length = 459

 Score =  887 bits (2293), Expect = 0.0
 Identities = 447/462 (96%), Positives = 449/462 (97%), Gaps = 3/462 (0%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V   + +  KAEELYQ
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFYKAEELYQ 237

Query: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300
           KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
Sbjct: 238 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 297

Query: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360
           PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
Sbjct: 298 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 357

Query: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420
           ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
Sbjct: 358 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 417

Query: 421 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 462
           SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
Sbjct: 418 SERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 459


>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
          Length = 640

 Score =  853 bits (2204), Expect = 0.0
 Identities = 423/424 (99%), Positives = 424/424 (100%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240

Query: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300
           KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
Sbjct: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300

Query: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360
           PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
Sbjct: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360

Query: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420
           ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
Sbjct: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420

Query: 421 SERH 424
           SER+
Sbjct: 421 SERY 424


>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
          Length = 637

 Score =  811 bits (2096), Expect = 0.0
 Identities = 408/424 (96%), Positives = 411/424 (96%), Gaps = 3/424 (0%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V   + +  KAEELYQ
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFYKAEELYQ 237

Query: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300
           KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
Sbjct: 238 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 297

Query: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360
           PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
Sbjct: 298 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 357

Query: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420
           ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
Sbjct: 358 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 417

Query: 421 SERH 424
           SER+
Sbjct: 418 SERY 421


>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
          Length = 420

 Score =  811 bits (2094), Expect = 0.0
 Identities = 408/423 (96%), Positives = 410/423 (96%), Gaps = 3/423 (0%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQ 240
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V   + +  KAEELYQ
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV---MASFYKAEELYQ 237

Query: 241 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 300
           KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN
Sbjct: 238 KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN 297

Query: 301 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 360
           PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT
Sbjct: 298 PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT 357

Query: 361 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 420
           ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
Sbjct: 358 ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH 417

Query: 421 SER 423
           SER
Sbjct: 418 SER 420


>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
          Length = 645

 Score =  808 bits (2087), Expect = 0.0
 Identities = 407/429 (94%), Positives = 409/429 (95%), Gaps = 5/429 (1%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKA 235
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V             +A
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240

Query: 236 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 295
           EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300

Query: 296 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 355
           PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360

Query: 356 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 415
           SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420

Query: 416 RDSPHSERH 424
           RDSPHSER+
Sbjct: 421 RDSPHSERY 429


>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
          Length = 624

 Score =  743 bits (1918), Expect = 0.0
 Identities = 374/396 (94%), Positives = 376/396 (94%), Gaps = 5/396 (1%)

Query: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72

Query: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132

Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
           IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 
Sbjct: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192

Query: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
             FTG RC   V             +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252

Query: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312

Query: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372

Query: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 424
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 408


>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
          Length = 607

 Score =  700 bits (1807), Expect = 0.0
 Identities = 356/396 (89%), Positives = 359/396 (90%), Gaps = 22/396 (5%)

Query: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72

Query: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS   
Sbjct: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129

Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 
Sbjct: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175

Query: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
             FTG RC   V             +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235

Query: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295

Query: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355

Query: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 424
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 391


>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
          Length = 590

 Score =  662 bits (1707), Expect = 0.0
 Identities = 339/396 (85%), Positives = 342/396 (86%), Gaps = 39/396 (9%)

Query: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72

Query: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112

Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 
Sbjct: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158

Query: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
             FTG RC   V             +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218

Query: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278

Query: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338

Query: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 424
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 374


>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
          Length = 308

 Score =  606 bits (1562), Expect = e-173
 Identities = 294/296 (99%), Positives = 296/296 (100%)

Query: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 226
           ++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP
Sbjct: 13  TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72

Query: 227 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 286
           MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
Sbjct: 73  MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132

Query: 287 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 346
           NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
Sbjct: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192

Query: 347 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 406
           VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
Sbjct: 193 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 252

Query: 407 HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 462
           HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
Sbjct: 253 HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 308


>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
          Length = 241

 Score =  431 bits (1109), Expect = e-121
 Identities = 218/225 (96%), Positives = 218/225 (96%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 225
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225


>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
          Length = 211

 Score =  418 bits (1075), Expect = e-117
 Identities = 211/211 (100%), Positives = 211/211 (100%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211


>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
          Length = 194

 Score =  375 bits (964), Expect = e-104
 Identities = 193/211 (91%), Positives = 194/211 (91%), Gaps = 17/211 (8%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESNEIITGMPASTEGAYV                 SS+TSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYV-----------------SSATSTSTTGTSHLV 163

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 164 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194


>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
          Length = 207

 Score =  350 bits (898), Expect = 2e-96
 Identities = 183/225 (81%), Positives = 184/225 (81%), Gaps = 34/225 (15%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESN                                  +TSTSTTGTSHLV
Sbjct: 121 DSASANITIVESN----------------------------------ATSTSTTGTSHLV 146

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 225
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V
Sbjct: 147 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 191


>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
          Length = 177

 Score =  337 bits (864), Expect = 1e-92
 Identities = 176/211 (83%), Positives = 177/211 (83%), Gaps = 34/211 (16%)

Query: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
           MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1   MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60

Query: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
           SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61  SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120

Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
           DSASANITIVESN                                  +TSTSTTGTSHLV
Sbjct: 121 DSASANITIVESN----------------------------------ATSTSTTGTSHLV 146

Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
           KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 147 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177


>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
          Length = 422

 Score =  286 bits (731), Expect = 4e-77
 Identities = 153/204 (75%), Positives = 155/204 (75%), Gaps = 34/204 (16%)

Query: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296

Query: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348

Query: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382

Query: 202 LSNPSRYLCKCQPGFTGARCTENV 225
           LSNPSRYLCKC   FTG RC   V
Sbjct: 383 LSNPSRYLCKCPNEFTGDRCQNYV 406


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score =  275 bits (704), Expect = 5e-74
 Identities = 169/428 (39%), Positives = 242/428 (56%), Gaps = 67/428 (15%)

Query: 11  GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
           GK  KKE G     + A         P+LK+MKSQ    G K  L+CE ++      ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270

Query: 71  FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
           FK+G ELNR    ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + 
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327

Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
           +                                  N+ S+T +S +G  H  KC E  K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351

Query: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV---QNQEKAEELYQKRVLT 245
           +CVNGG C+ ++ ++  S   CKC  GF G RC E +P+++     ++KAEELYQKRVLT
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLT 408

Query: 246 ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPEN 305
           ITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N  ++ANGP HP   PE 
Sbjct: 409 ITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEE 467

Query: 306 VQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHT 360
           +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T T      SH+WS   +
Sbjct: 468 IQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERS 526

Query: 361 ESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYR 416
           ES+ S+S S I++SSV  S+ +SP        R         R   +   H  ++ DS R
Sbjct: 527 ESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLR 584

Query: 417 DSPHSERH 424
           DSPHSER+
Sbjct: 585 DSPHSERY 592


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score =  270 bits (691), Expect = 2e-72
 Identities = 168/425 (39%), Positives = 238/425 (56%), Gaps = 67/425 (15%)

Query: 11  GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
           GK  KKE G     + A         P+LK+MKSQ    G K  L+CE ++      ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270

Query: 71  FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
           FK+G ELNR    ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + 
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327

Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
           +                                  N+ S+T +S +G  H  KC E  K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351

Query: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITG 248
           +CVNGG C+ ++ ++  S   CKC  G+TG RC +     + N  KAEELYQKRVLTITG
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQ---FAMVNFSKAEELYQKRVLTITG 405

Query: 249 ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQL 308
           IC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N  ++ANGP HP   PE +Q+
Sbjct: 406 ICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQM 464

Query: 309 VNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESI 363
            + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T T      SH+WS   +ES+
Sbjct: 465 AD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESL 523

Query: 364 LSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP 419
            S+S S I++SSV  S+ +SP        R         R   +   H  ++ DS RDSP
Sbjct: 524 TSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSP 581

Query: 420 HSERH 424
           HSER+
Sbjct: 582 HSERY 586


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score =  270 bits (689), Expect = 3e-72
 Identities = 168/436 (38%), Positives = 241/436 (55%), Gaps = 75/436 (17%)

Query: 11  GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
           GK  KKE G     + A         P+LK+MKSQ    G K  L+CE ++      ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270

Query: 71  FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
           FK+G ELNR    ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + 
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327

Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
           +                                  N+ S+T +S +G  H  KC E  K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351

Query: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQE-----------KAEE 237
           +CVNGG C+ ++ ++  S   CKC  GF G RC E +P+++   +           +AEE
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEE 408

Query: 238 LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPH 297
           LYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N  ++ANGP 
Sbjct: 409 LYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPS 467

Query: 298 HPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PS 352
           HP   PE +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T T      S
Sbjct: 468 HPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHES 526

Query: 353 HSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHA 408
           H+WS   +ES+ S+S S I++SSV  S+ +SP        R         R   +   H 
Sbjct: 527 HTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH- 585

Query: 409 RETPDSYRDSPHSERH 424
            ++ DS RDSPHSER+
Sbjct: 586 -DSVDSLRDSPHSERY 600


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score =  266 bits (680), Expect = 3e-71
 Identities = 166/430 (38%), Positives = 238/430 (55%), Gaps = 69/430 (16%)

Query: 11  GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
           GK  KKE G     + A         P+LK+MKSQ    G K  L+CE ++      ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270

Query: 71  FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
           FK+G ELNR    ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + 
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327

Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
           +                                  N+ S+T +S +G  H  KC E  K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351

Query: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKAEELYQKRV 243
           +CVNGG C+ ++ ++  S   CKC  G+TG RC +   +          ++AEELYQKRV
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408

Query: 244 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 303
           LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N  ++ANGP HP   P
Sbjct: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467

Query: 304 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 358
           E +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T T      SH+WS  
Sbjct: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526

Query: 359 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 414
            +ES+ S+S S I++SSV  S+ +SP        R         R   +   H  ++ DS
Sbjct: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584

Query: 415 YRDSPHSERH 424
            RDSPHSER+
Sbjct: 585 LRDSPHSERY 594


>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
          Length = 296

 Score =  109 bits (272), Expect = 6e-24
 Identities = 51/58 (87%), Positives = 51/58 (87%)

Query: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 225
           STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG RC   V
Sbjct: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280


>gi|66730481 neuregulin 3 [Homo sapiens]
          Length = 696

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 71/269 (26%), Positives = 126/269 (46%), Gaps = 31/269 (11%)

Query: 149 SSESPIRISVSTEGANTSSS-----TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 203
           SS S    S +T    TS+S     T+ ST  + H   C +K+  +C+N GECF+++ L+
Sbjct: 252 SSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLT 311

Query: 204 NPSRYLCKCQPGFTGARCTENVP------------MKVQNQEKAEELYQKRVLTITGICI 251
              ++ C+C+ G+ G RC + +P            + ++  E +EE+YQ++VL+I+ I  
Sbjct: 312 GSHKH-CRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFME-SEEVYQRQVLSISCIIF 369

Query: 252 ALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVN- 310
            +++VG+ C   Y K+KKQ K++ ++L+     +  ++   +      N    +VQL N 
Sbjct: 370 GIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNY 429

Query: 311 QYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH-SWSNGHTESILSESHS 369
             V ++ +++   +E+  E+SF           S     +P   S S  H  S+ S    
Sbjct: 430 SKVERHPVTA---LEKMMESSF-------VGPQSFPEVPSPDRGSQSVKHHRSLSSCCSP 479

Query: 370 VIVMSSVENSRHSSPTGGPRGRLNGTGGP 398
                 +  +        PR RL G  GP
Sbjct: 480 GQRSGMLHRNAFRRTPPSPRSRLGGIVGP 508


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189

Query: 96    ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
              L I  AS++DSG+Y  K  +  G  SA+A++ ++      S E++  T    S +G++ 
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 33248

Query: 149   SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
              S   +++S S + A+ SS +S+S +  + +
Sbjct: 33249 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 33278



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 4/99 (4%)

Query: 34   ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509

Query: 94   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 132
             S L I +  + D GEY CK  ++ G+ S +A +T+ E+
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEA 3548



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 26/98 (26%), Positives = 49/98 (50%), Gaps = 5/98 (5%)

Query: 35   LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
            +PP   K++   +   GS + + C+ S     +  +WFK+G E++   K + +  ++   
Sbjct: 5235 IPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVCHERSVS 5293

Query: 94   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
               L +N   L D+  Y CKV +  G+D+ S  +T+ E
Sbjct: 5294 ---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKE 5328



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 42/165 (25%), Positives = 72/165 (43%), Gaps = 21/165 (12%)

Query: 31   QSPALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQ 89
            Q   LPP   +++K  E   G  + L C  +   + ++  W+++G  L      +N++  
Sbjct: 6169 QERQLPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQTS 6224

Query: 90   KKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE------------SNEIIT 137
                 + L+I +  L+ SG+Y C   + LG  S+SA +T  E            S ++I 
Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIA 6284

Query: 138  GMPASTEGAYVSSESPIRISVSTEGANT---SSSTSTSTTGTSHL 179
            G  A  E  +V+   P+RI+ S +        + T T    T HL
Sbjct: 6285 GESADFE-CHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHL 6328



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 37/126 (29%), Positives = 67/126 (53%), Gaps = 8/126 (6%)

Query: 36   PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
            PP+ +K++++ + A  G  + L C+ S     ++  WF+N +EL+   K     I     
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419

Query: 94   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
             + L IN+AS  DSG+Y+C+  + +G+ S S  +T V++  + T  P S  GA   S+  
Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALT-VKAPPVFTQKP-SPVGALKGSDVI 6476

Query: 154  IRISVS 159
            ++  +S
Sbjct: 6477 LQCEIS 6482



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 45/201 (22%), Positives = 83/201 (41%), Gaps = 33/201 (16%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +++ +S       L C+ +     +R  WFK+G E+   ++    +I    G + L I
Sbjct: 4117 KPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR---YRIAFVEGTASLEI 4172

Query: 100  NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
             +  + D+G + C+  + +G+  +S  + + E    +T  P S +   V   S + +  +
Sbjct: 4173 IRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVT-KPGSKD---VLPGSAVCLKST 4228

Query: 160  TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSR 207
             +G         ST  T    K   KE    V+GG C++ K+             S+   
Sbjct: 4229 FQG---------STPLTIRWFK-GNKE---LVSGGSCYITKEALESSLELYLVKTSDSGT 4275

Query: 208  YLCKCQPGFTGARCTENVPMK 228
            Y CK      G  C+ N+ +K
Sbjct: 4276 YTCKVSNVAGGVECSANLFVK 4296



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 5/98 (5%)

Query: 35   LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
            +PP   K++K  +S  GS + L C  +  +  +  +WFK+  E++   K    K      
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKDDQEISASEK---YKFSFHDN 4728

Query: 94   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
             + L I++    DSG Y C   +K G++  S ++T+ E
Sbjct: 4729 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 4/96 (4%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P   +++K     +GS +V+ C+       +   WF  GNE++   K Q           
Sbjct: 7682 PSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNT---C 7737

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
             L +N    +DSG+Y C   +  G+D  SA +T+ E
Sbjct: 7738 ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE 7773



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 4/96 (4%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  +KE++  +SA   K+ L C+   +   +   W K+G +L      ++ KI  +   +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
             L I  A L DSG Y+C   ++ G+ S SA +T+ E
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVRE 3735



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)

Query: 52    KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
             ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732

Query: 112   CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
             C      G D   AN+T VE+  I    P      +V   +   I +S
Sbjct: 11733 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 11775



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 47/227 (20%), Positives = 91/227 (40%), Gaps = 32/227 (14%)

Query: 31   QSPALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQ 89
            + P  PP   +  +  + + G  + L C        +R +W K G E+   ++       
Sbjct: 8340 KEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR---CSFS 8395

Query: 90   KKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGA--- 146
               G + L +   + ADSG+Y+CK  +  G+D+  + +TI +   +    PA+ + A   
Sbjct: 8396 FASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAV---APATKKAAVDG 8452

Query: 147  ---YVSSESPIRISVSTEGANTSSSTSTSTTGTSHL--VKCAEKEKTFCVNGGECFM--- 198
               +VS    IR+   T      ++T  +  G   +  VK  + +      GG  F+   
Sbjct: 8453 RLFFVSEPQSIRVVEKT------TATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQK 8506

Query: 199  -------VKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEEL 238
                   ++D +     L +C           NV ++V  ++K E++
Sbjct: 8507 GDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKI 8553



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            +++ +S +   G    L C T +    L  KWFK+G EL   NK +     K  G   L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESN--EIITGMPASTEGAYVSS------ 150
            I   + +DSG Y  +V + +G DS +A++ + +       T     T G   SS      
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECK 7704

Query: 151  ---ESPIRISVSTEGANTSSSTSTSTTGTSH 178
                 PI +S   EG   SS     TT T +
Sbjct: 7705 VYGSPPISVSWFHEGNEISSGRKYQTTLTDN 7735



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/172 (24%), Positives = 72/172 (41%), Gaps = 22/172 (12%)

Query: 17   ERGSGKKPESAAGSQSPALPPR--LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNG 74
            E  SGK   SA   Q   L P   +K+++  + + G    L+C+ +     +   W+K  
Sbjct: 7943 ENASGKDSCSA---QILILEPPYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGD 7998

Query: 75   NELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN- 133
             +L         K+  +   + L  N+  + DSGEY+CK  + +G  SAS  +T+ E   
Sbjct: 7999 TKLRPTT---TYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKL 8055

Query: 134  -----------EIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTT 174
                       +   G+P   + A +S   PI +S   +G     S +  T+
Sbjct: 8056 PPSFSRQLRDVQETVGLPVVFDCA-ISGSEPISVSWYKDGKPLKDSPNVQTS 8106



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 13/101 (12%)

Query: 66   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
            ++  WFKN  EL+  N    +++     ++ L I    + DSG Y C+ ++ +G+DS S 
Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823

Query: 126  NITI---------VESNEIITGMPASTEGAYVSSESPIRIS 157
             I I         +E  +I+ G  A  +   VS   P  IS
Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQ-CEVSGTGPFEIS 3863



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 32/130 (24%), Positives = 57/130 (43%), Gaps = 14/130 (10%)

Query: 34   ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
            + PP ++ +K+ E +      L CE S         W+K+  +L    K    KI  K  
Sbjct: 5521 SFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKNF 5570

Query: 94   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
             + + I     +D GEY CK  +++G+D+    + + E    ++ + + T    V +  P
Sbjct: 5571 HTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLT----VVAGEP 5626

Query: 154  IRISVSTEGA 163
              +  S EGA
Sbjct: 5627 AELQASIEGA 5636



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 5/116 (4%)

Query: 17   ERGSGKKPESAAGSQSPALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGN 75
            E  +G    S + + +   PP   +  S   A  GS ++L+CE S         W K+  
Sbjct: 6438 EAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRK 6496

Query: 76   ELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
            ++    K    KI  K   + L I     +D GEY CK  +++G+D+ S ++   E
Sbjct: 6497 QVRNSKK---FKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKE 6549



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 24/89 (26%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 44   SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 103
            SQ    G    L C+ +     ++  WF N  E+   +K +   ++     + LR+    
Sbjct: 4308 SQLLKKGDATQLACKVTGT-PPIKITWFANDREIKESSKHRMSFVEST---AVLRLTDVG 4363

Query: 104  LADSGEYMCKVISKLGNDSASANITIVES 132
            + DSGEYMC+  ++ G+D  S+ + + ES
Sbjct: 4364 IEDSGEYMCEAQNEAGSDHCSSIVIVKES 4392



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 13/113 (11%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  ++++K   +  G+ +VL C  S   + +   WF++GNE+    K Q+          
Sbjct: 6741 PSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQS---SFSENVC 6796

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIITGM 139
             L ++    +D+G Y C   +  G+D  SA +T+ E         S E++ GM
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGM 6849



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/108 (25%), Positives = 45/108 (41%), Gaps = 4/108 (3%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  ++E+K  E    S + L CE +         W KN  E+    K     +  +    
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAST 143
             L I K   +D+GEY C V ++ G+ S S  + + E    I  +  +T
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT 5058



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  ++ ++  E+  G    L+C+       +R  W+K   +L  ++ P   K+Q K   +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             L INK   +D GEY CK  + +G  ++SA + I
Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 35/149 (23%), Positives = 60/149 (40%), Gaps = 16/149 (10%)

Query: 25   ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
            ++  GS +   PPR  +  S  S    K V    T      +   WFK+  E+ R++   
Sbjct: 7480 DTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--D 7537

Query: 85   NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
            NI I      + L+ ++   A++G+Y C++ +  G     A ++++E   I+        
Sbjct: 7538 NIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIV-------- 7589

Query: 145  GAYVSSESPIRISVSTEGANTSSSTSTST 173
                  E P  I V+T    T   T   T
Sbjct: 7590 ------EKPESIKVTTGDTCTLECTVAGT 7612



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 30/111 (27%), Positives = 48/111 (43%), Gaps = 11/111 (9%)

Query: 26   SAAGSQSPALPPRLKEMK-------SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
            +AAGS S +   ++KE           E+  G+ + L CE           W+K+  EL 
Sbjct: 7382 NAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGT-PPFHVSWYKDKRELR 7440

Query: 79   RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
               K    KI  +   + + I     AD GEY CK  + +G+D+   +I +
Sbjct: 7441 SGKK---YKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIAL 7488



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 14/109 (12%)

Query: 57    CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
             CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 12395 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 12449

Query: 117   KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGA 163
                    S  +T++E   + T   A+ E   VS    I++   VS  GA
Sbjct: 12450 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGA 12491



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)

Query: 33   PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
            P  PP L   +K+     G  + L C  S  Y S    W++   ++       + +I  +
Sbjct: 939  PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 994

Query: 92   PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
             G + L I +A   DSG + C  +++ G  S S  + +  S E      A TE
Sbjct: 995  SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 28/115 (24%), Positives = 55/115 (47%), Gaps = 7/115 (6%)

Query: 30   SQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQ 89
            ++ P    +L+  K  ++   S+L  +   S E   +R  WF+N +EL   +K +   I 
Sbjct: 5420 TEPPKFVKKLEASKIVKAGDSSRLECKIAGSPE---IRVVWFRNEHELPASDKYRMTFID 5476

Query: 90   KKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
                 + +++N  S  DSG+++C+  +  G+ S S  + IV+   + +  P   E
Sbjct: 5477 SV---AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKV-IVKEPPVFSSFPPIVE 5527



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 4/94 (4%)

Query: 49   AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 108
            AG      C  +     +R  W K+  E+       N  I        LRI K    DSG
Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339

Query: 109  EYMCKVISKLGNDSASANITIVESNEIITGMPAS 142
            +Y C+  + +G D  SA +++ E  + +  + AS
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEAS 6373



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 45/200 (22%), Positives = 76/200 (38%), Gaps = 16/200 (8%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  + E++  E+A G  + L+C+ +     +   W+K   +L         +       +
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGT-PEITVSWYKGDTKLR---PTPEYRTYFTNNVA 6134

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIR 155
             L  NK ++ DSGEY CK  + +G  S+     I E       +P S        E  + 
Sbjct: 6135 TLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQ-----LPPSFARQLKDIEQTVG 6189

Query: 156  ISVS-TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV--KDLSNPSRYLCKC 212
            + V+ T   N S+           L++  E  +T  V+      +   DLS+  +Y C  
Sbjct: 6190 LPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSA 6249

Query: 213  Q----PGFTGARCTENVPMK 228
                    + AR T   P K
Sbjct: 6250 SNPLGTASSSARLTAREPKK 6269



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 13/123 (10%)

Query: 44   SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 103
            S++   GS + L+  T    + L  +WFK   EL       +  I K+  +S L +    
Sbjct: 4214 SKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG---SCYITKEALESSLELYLVK 4269

Query: 104  LADSGEYMCKVISKLGNDSASANITI---------VESNEIITGMPASTEGAYVSSESPI 154
             +DSG Y CKV +  G    SAN+ +         +E ++++    A+     V+   PI
Sbjct: 4270 TSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPI 4329

Query: 155  RIS 157
            +I+
Sbjct: 4330 KIT 4332



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 4/102 (3%)

Query: 36   PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 94
            PPR +K++    +  G  + LR      +  +   W K+  E+ R++  +N +I      
Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606

Query: 95   SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
            + L++     ++SG+Y+C++ +  G    SA +T++E   II
Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARII 6648



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 43/206 (20%), Positives = 83/206 (40%), Gaps = 16/206 (7%)

Query: 46   ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 105
            ++  G      C  +     ++  W K+  E+    K Q   ++     + L+++K    
Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218

Query: 106  DSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEG--A 163
            DSG+Y C  ++++G DS +A + I E   +I   P+ T+    + E     S   EG  A
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKE--RLIP--PSFTKRLSETVEETEGNSFKLEGRVA 8274

Query: 164  NTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVK--DLSNPSRYLCKCQPGFTGARC 221
             +   T         +   +  E TF  N      V+   +++   Y CK       A C
Sbjct: 8275 GSQPITVAWYKNNIEIQPTSNCEITF-KNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALC 8333

Query: 222  TENVPMKVQNQEKAEELYQKRVLTIT 247
            T ++ +K   + K   ++ + +  +T
Sbjct: 8334 TSSIVIK---EPKKPPVFDQHLTPVT 8356



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)

Query: 25   ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
            E  AG   PA P  + +   Q+   G  +V  C+         + W K+G  L    +  
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1128

Query: 85   NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
             +   K+ G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1129 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 32717 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 32771

Query: 93    GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
             G  EL+IN  + +D GEY+C++  + G    +           +E ++ +  + +    +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 32831

Query: 150   SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
             +ES +      +     SS     TG       ++    F V
Sbjct: 32832 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 32873



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)

Query: 69   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
            KWFK+G EL   +K    KI      S L+I      DSGEY  +V + +G  S  A I 
Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667

Query: 129  IVE 131
            +++
Sbjct: 4668 VLD 4670



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 44/193 (22%), Positives = 77/193 (39%), Gaps = 17/193 (8%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            KE K  E      ++L  E +         WFK+ N + R  +     IQ       L+I
Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452

Query: 100  NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
             K   AD+GEY C+V +++G+   SA +T+ E    I           + S S +R   +
Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFI---------KKIESTSSLRGGTA 4503

Query: 160  TEGANTSSSTSTSTTGTSHLVKCAEKEK---TFCVNGGECFMVK-DLSNPSRYLCKCQPG 215
               A    S   + T      +  E +    TF  N    ++   ++ +  +Y+C+ +  
Sbjct: 4504 AFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563

Query: 216  FTGARCTENVPMK 228
                RC+  + +K
Sbjct: 4564 AGIQRCSALLSVK 4576



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 37/202 (18%), Positives = 83/202 (41%), Gaps = 26/202 (12%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  +++ +SQ+    +++ L+       + +  KWFK+  EL+         + K    +
Sbjct: 4768 PYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWKDDTST 4823

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNE---------IITGMPASTEGA 146
             L +  A   DSG Y+C++ + +G  ++ A + + E  +         ++    ++T   
Sbjct: 4824 SLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFEC 4883

Query: 147  YVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPS 206
             ++    IR+S   +G       +  T    H +   +   TF ++G        + N  
Sbjct: 4884 QITGTPKIRVSWYLDG-------NEITAIQKHGISFIDGLATFQISGAR------VENSG 4930

Query: 207  RYLCKCQPGFTGARCTENVPMK 228
             Y+C+ +     A C+  + +K
Sbjct: 4931 TYVCEARNDAGTASCSIELKVK 4952



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)

Query: 14    KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
             +K   GSG  K P+ A  + Q  A+P + +KE+K    ++    GS  +  C  S   S+
Sbjct: 11089 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 11146

Query: 66    LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
                 W K+G+ +    K + I   K     +L I    L+D+GEY C  + +LGN   ++
Sbjct: 11147 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 11201

Query: 126   NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
                +V     +  +    E   V    P+ +S
Sbjct: 11202 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 11233



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 16/60 (26%), Positives = 28/60 (46%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 8/120 (6%)

Query: 23   KPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLR------FKWFKNGNE 76
            K ++  GS +     +LKE     S   S  V+  E +   +S+        +W K   E
Sbjct: 5590 KAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEE 5649

Query: 77   LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
            + R++  +NI+I      + L+  KA  A++G+Y+C++ +  G     A + ++E   I+
Sbjct: 5650 VIRES--ENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIV 5707



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 28/116 (24%), Positives = 48/116 (41%), Gaps = 13/116 (11%)

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            WFK  +EL   ++     +  +   +EL +     + SGEY C V ++ G  S + ++ I
Sbjct: 7808 WFKGSSELVPGDR---CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI 7864

Query: 130  ---------VESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGT 176
                     +    I  G P   EG +  +  PI ++    G N + S   + T T
Sbjct: 7865 KAPAKFVKRLNDYSIEKGKPLILEGTFTGT-PPISVTWKKNGINVTPSQRCNITTT 7919



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 32/139 (23%), Positives = 52/139 (37%), Gaps = 16/139 (11%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            +K +       G  L+L   T +    +   W KNG  +      Q   I      + L 
Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISV 158
            I  +++ D+G+Y C + +  G DS SA I I+E               +V    P+++SV
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE------------PPYFVKQLEPVKVSV 7974

Query: 159  STEGANTSSSTSTSTTGTS 177
                +       T   G S
Sbjct: 7975 GDSASLQCQLAGTPEIGVS 7993



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +TI
Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 37/176 (21%), Positives = 69/176 (39%), Gaps = 11/176 (6%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK +       G  ++L   T +    +   W K+G  +    K   +  +K      L 
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISV 158
            I  ++  D+G+Y C++ ++ G D   A ++ +E    +T +    E A   S     +S+
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTEL-EPLEAAVGDS-----VSL 6098

Query: 159  STEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVK-DLSNPSRYLCKCQ 213
              + A T   T +   G + L    E    F  N       K ++++   Y CK +
Sbjct: 6099 QCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAE 6154



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 4/80 (5%)

Query: 50   GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 109
            G+   L C  +     L  KWFK+G EL+  +K     I K    + L+I  A ++D G 
Sbjct: 6659 GNPFALECVVTGT-PELSAKWFKDGRELSADSKHHITFINK---VASLKIPCAEMSDKGL 6714

Query: 110  YMCKVISKLGNDSASANITI 129
            Y  +V + +G  + + ++ +
Sbjct: 6715 YSFEVKNSVGKSNCTVSVHV 6734



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 13/119 (10%)

Query: 67   RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 126
            + KWFK   EL      ++  I  +   +EL + +    +SG+Y C V +  G+ S + +
Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920

Query: 127  ITIVESNEII---------TGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGT 176
            + + E    +         TG P   E  Y  +  PI +S   +    S S   S T T
Sbjct: 6921 LFVKEPATFVKRLADFSVETGSPIVLEATYTGT-PPISVSWIKDEYLISQSERCSITMT 6978



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 40    KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
             K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 4/96 (4%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  +K ++  +   G+  +L+CE S         WFK+  ++ R +K   +  QK     
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
             L I   + AD GEY C V +++G     A   + E
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKE 3922



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 5/104 (4%)

Query: 34   ALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 92
            A PP  L   KS  +  G      C T +    +   W K+G  L+      N +I    
Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFIC-TVTGTPVIETIWQKDGAALSPS---PNWRISDAE 3603

Query: 93   GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
             K  L ++  ++ D G Y CK  +K G D   A + I++    I
Sbjct: 3604 NKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFI 3647



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 4/99 (4%)

Query: 44   SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 103
            S + A G     +C  +   + ++  W K+  E+       N K+      + L + K  
Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275

Query: 104  LADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAS 142
              D+G+Y C   +  G DS SA + + E    I  +  S
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS 7314



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 33/164 (20%), Positives = 65/164 (39%), Gaps = 11/164 (6%)

Query: 67   RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 126
            + KWFK+  EL    K     I  +   S L +     + +G+Y C V + +G+DS +  
Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416

Query: 127  ITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKE 186
            + + E  + +  + AS     V +    R+     G   S           H +  ++K 
Sbjct: 5417 LLVTEPPKFVKKLEAS---KIVKAGDSSRLECKIAG---SPEIRVVWFRNEHELPASDKY 5470

Query: 187  KTFCVNGGECFMVKDLS--NPSRYLCKCQPGFTGARCTENVPMK 228
            +   ++      + +LS  +   ++C+ Q       C+  V +K
Sbjct: 5471 RMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVK 5514



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 23/99 (23%), Positives = 41/99 (41%), Gaps = 5/99 (5%)

Query: 34   ALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 92
            A+PP   + +K+     G+  +L C+ +   S +   WF    ++    K Q        
Sbjct: 5797 AVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF---SD 5852

Query: 93   GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
                L++N    +D G Y C   +  G+D   A +T+ E
Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)

Query: 57    CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 31589 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 31645

Query: 117   KLGNDSASANITIVESNEI 135
               G DS+ A + +    E+
Sbjct: 31646 DYGEDSSYAELFVKGVREV 31664



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)

Query: 49    AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 20392 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 20447

Query: 108   GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
             GEY     +  G       +T+++    + G P   E + VS+E
Sbjct: 20448 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 20487



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 4/82 (4%)

Query: 50   GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 109
            G      C+ +     +R  W+ +GNE+    K     I    G +  +I+ A + +SG 
Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931

Query: 110  YMCKVISKLGNDSASANITIVE 131
            Y+C+  +  G  S S  + + E
Sbjct: 4932 YVCEARNDAGTASCSIELKVKE 4953



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 25/119 (21%), Positives = 48/119 (40%), Gaps = 13/119 (10%)

Query: 67   RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 126
            +  WF+   EL + ++     I  +   +EL +    ++ SGEY C V +  G  S +  
Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979

Query: 127  ITIVE---------SNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGT 176
            + + E          + +  G     E  Y  +  PI ++   +G N ++S   +   T
Sbjct: 5980 LFVKEPAAFLKRLSDHSVEPGKSIILESTYTGT-LPISVTWKKDGFNITTSEKCNIVTT 6037



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 15/66 (22%), Positives = 35/66 (53%), Gaps = 3/66 (4%)

Query: 66   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
            ++  W+K+  E+   +K    ++      + L ++  S+ DSG+Y C+  +  G+ S+S 
Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391

Query: 126  NITIVE 131
            ++ + E
Sbjct: 7392 SLKVKE 7397



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)

Query: 39    LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
             LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 12646 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 12697

Query: 99    INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
             I  A L D   Y   + +  G +  SA   IVE  ++
Sbjct: 12698 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 12734



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 39    LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
             ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880

Query: 99    INKASLADSGEYMCKV 114
             I    L D  EY C V
Sbjct: 12881 IKDCRLDDECEYACGV 12896



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476

Query: 130   V 130
             +
Sbjct: 14477 I 14477



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678

Query: 100  NKASLADSGEYMCKV 114
                L D GEY  KV
Sbjct: 2679 AATKLDDIGEYTYKV 2693



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026

Query: 99   INKASLADSGEY 110
            I      D+ +Y
Sbjct: 3027 IRNVHFGDAADY 3038



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)

Query: 69   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1737 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1793

Query: 129  IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
            + +   ++  + +P   +G     E      ++ EGA T  +T
Sbjct: 1794 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1833



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)

Query: 67    RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
             + +W KN   + +      I   ++ +   K+EL I KA   D G Y     ++LG+   
Sbjct: 15429 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 15488

Query: 124   SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
             + ++ + +      N  +T + A  E  Y++ ++P+
Sbjct: 15489 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 15522



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 32/163 (19%), Positives = 65/163 (39%), Gaps = 16/163 (9%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            P  +K+++S  S  G     +         +   W K+ +E+   +   NI++  +   +
Sbjct: 4486 PSFIKKIESTSSLRGGTAAFQATLKGSLP-ITVTWLKDSDEITEDD---NIRMTFENNVA 4541

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIITGMPASTEGA 146
             L ++   +   G+Y+C+  +  G    SA +++ E         S ++  G PA+ +  
Sbjct: 4542 SLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVK 4601

Query: 147  YVSSESPIRISVSTEGANTS--SSTSTSTTGTSHLVKCAEKEK 187
            + S    I      +G   +  S    S T T  ++K    EK
Sbjct: 4602 F-SGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEK 4643



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 39    LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
             LK++ ++E  +    V   E S  + ++R KWFKN   L   +  +++ +Q +     + 
Sbjct: 11935 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 11986

Query: 99    INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
                 S+ D+ +   + +      S+ A +T++E +   TG
Sbjct: 11987 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 12022



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 21/80 (26%), Positives = 34/80 (42%), Gaps = 4/80 (5%)

Query: 50   GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 109
            G    L C+ +     L  +W+K+G  L    K +     K    S LRI      D+G 
Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773

Query: 110  YMCKVISKLGNDSASANITI 129
            Y  +V + +G  S +A + +
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDV 5793



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293

Query: 130   VE 131
             ++
Sbjct: 18294 LD 18295



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)

Query: 35    LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
             +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   I+    
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 33384

Query: 94    KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 33385 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 29.3 bits (64), Expect = 7.9
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3062 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3116

Query: 100  NKASLADSGEY 110
                ++D+G+Y
Sbjct: 3117 PSTRMSDAGKY 3127


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884

Query: 96    ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
              L I  AS++DSG+Y  K  +  G  SA+A++ ++      S E++  T    S +G++ 
Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26943

Query: 149   SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
              S   +++S S + A+ SS +S+S +  + +
Sbjct: 26944 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26973



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)

Query: 20   SGKKPESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
            SGK   SA  +      P +K +++  E A G      CE  S   ++RF+WFK G E+ 
Sbjct: 4512 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIY 4570

Query: 79   RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              +K     I+     S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4571 ESDK---CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)

Query: 52   KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427

Query: 112  CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
            C      G D   AN+T VE+  I    P      +V   +   I +S
Sbjct: 5428 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5470



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 14/109 (12%)

Query: 57   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
            CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 6090 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6144

Query: 117  KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGA 163
                   S  +T++E   + T   A+ E   VS    I++   VS  GA
Sbjct: 6145 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGA 6186



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)

Query: 33   PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
            P  PP L   +K+     G  + L C  S  Y S    W++   ++       + +I  +
Sbjct: 893  PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 948

Query: 92   PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
             G + L I +A   DSG + C  +++ G  S S  + +  S E      A TE
Sbjct: 949  SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 3/135 (2%)

Query: 10   KGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK 69
            KG+G K         +S      P  P  LKE+K    A G   +       E +     
Sbjct: 3741 KGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VT 3799

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            WFK   +L          I    G     +N     DSG Y+CK  + LG  + +A + +
Sbjct: 3800 WFKENKQLC--TSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3857

Query: 130  VESNEIITGMPASTE 144
            +  +  +T  P   +
Sbjct: 3858 LLEDTDMTDTPCKAK 3872



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)

Query: 25   ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
            E  AG   PA P  + +   Q+   G  +V  C+         + W K+G  L    +  
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1082

Query: 85   NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
             +   K+ G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1083 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 26412 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26466

Query: 93    GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
             G  EL+IN  + +D GEY+C++  + G    +           +E ++ +  + +    +
Sbjct: 26467 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26526

Query: 150   SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
             +ES +      +     SS     TG       ++    F V
Sbjct: 26527 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26568



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)

Query: 14   KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
            +K   GSG  K P+ A  + Q  A+P + +KE+K    ++    GS  +  C  S   S+
Sbjct: 4784 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 4841

Query: 66   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
                W K+G+ +    K + I   K     +L I    L+D+GEY C  + +LGN   ++
Sbjct: 4842 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 4896

Query: 126  NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
               +V     +  +    E   V    P+ +S
Sbjct: 4897 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 4928



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 16/60 (26%), Positives = 28/60 (46%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +TI
Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)

Query: 57    CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 25284 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25340

Query: 117   KLGNDSASANITIVESNEI 135
               G DS+ A + +    E+
Sbjct: 25341 DYGEDSSYAELFVKGVREV 25359



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)

Query: 49    AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 14087 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14142

Query: 108   GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
             GEY     +  G       +T+++    + G P   E + VS+E
Sbjct: 14143 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 14182



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 6341 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6392

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
            I  A L D   Y   + +  G +  SA   IVE  ++
Sbjct: 6393 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6429



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575

Query: 99   INKASLADSGEYMCKV 114
            I    L D  EY C V
Sbjct: 6576 IKDCRLDDECEYACGV 6591



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171

Query: 130  V 130
            +
Sbjct: 8172 I 8172



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 100  NKASLADSGEYMCKV 114
                L D GEY  KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 99   INKASLADSGEY 110
            I      D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)

Query: 69   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747

Query: 129  IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
            + +   ++  + +P   +G     E      ++ EGA T  +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 36/150 (24%), Positives = 55/150 (36%), Gaps = 26/150 (17%)

Query: 97   LRINKASLAD-SGEYMCKVISKLGNDSASANITIV-----------ESNEIITGMPASTE 144
            L I+K +  D  GEY+C+ ++  G  + SA +T+V           E  E+  G  A   
Sbjct: 4490 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFT 4549

Query: 145  GAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSN 204
               + S   +R      G     S   S   +S  +   E  +T  V+ GE         
Sbjct: 4550 -CEIQSAPNVRFQWFKAGREIYESDKCSIR-SSKYISSLEILRTQVVDCGE--------- 4598

Query: 205  PSRYLCKCQPGFTGARCTENVPMKVQNQEK 234
               Y CK    +    CT  + + V   EK
Sbjct: 4599 ---YTCKASNEYGSVSCTATLTVTVPGGEK 4625



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)

Query: 67   RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
            + +W KN   + +      I   ++ +   K+EL I KA   D G Y     ++LG+   
Sbjct: 9124 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 9183

Query: 124  SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
            + ++ + +      N  +T + A  E  Y++ ++P+
Sbjct: 9184 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9217



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E  +    V   E S  + ++R KWFKN   L   +  +++ +Q +     + 
Sbjct: 5630 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5681

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
                S+ D+ +   + +      S+ A +T++E +   TG
Sbjct: 5682 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5717



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988

Query: 130   VE 131
             ++
Sbjct: 11989 LD 11990



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)

Query: 35    LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
             +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   I+    
Sbjct: 27022 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 27079

Query: 94    KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 27080 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115



 Score = 29.3 bits (64), Expect = 7.9
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070

Query: 100  NKASLADSGEY 110
                ++D+G+Y
Sbjct: 3071 PSTRMSDAGKY 3081


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26817

Query: 96    ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
              L I  AS++DSG+Y  K  +  G  SA+A++ ++      S E++  T    S +G++ 
Sbjct: 26818 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26876

Query: 149   SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
              S   +++S S + A+ SS +S+S +  + +
Sbjct: 26877 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26906



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)

Query: 20   SGKKPESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
            SGK   SA  +      P +K +++  E A G      CE  S   ++RF+WFK G E+ 
Sbjct: 4445 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIY 4503

Query: 79   RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              +K     I+     S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4504 ESDK---CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)

Query: 52   KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5307 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5360

Query: 112  CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
            C      G D   AN+T VE+  I    P      +V   +   I +S
Sbjct: 5361 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5403



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 14/109 (12%)

Query: 57   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
            CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 6023 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6077

Query: 117  KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGA 163
                   S  +T++E   + T   A+ E   VS    I++   VS  GA
Sbjct: 6078 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGA 6119



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)

Query: 33   PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
            P  PP L   +K+     G  + L C  S  Y S    W++   ++       + +I  +
Sbjct: 893  PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 948

Query: 92   PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
             G + L I +A   DSG + C  +++ G  S S  + +  S E      A TE
Sbjct: 949  SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 3/135 (2%)

Query: 10   KGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK 69
            KG+G K         +S      P  P  LKE+K    A G   +       E +     
Sbjct: 3674 KGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VT 3732

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            WFK   +L          I    G     +N     DSG Y+CK  + LG  + +A + +
Sbjct: 3733 WFKENKQLC--TSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3790

Query: 130  VESNEIITGMPASTE 144
            +  +  +T  P   +
Sbjct: 3791 LLEDTDMTDTPCKAK 3805



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)

Query: 25   ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
            E  AG   PA P  + +   Q+   G  +V  C+         + W K+G  L    +  
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1082

Query: 85   NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
             +   K+ G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1083 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 26345 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26399

Query: 93    GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
             G  EL+IN  + +D GEY+C++  + G    +           +E ++ +  + +    +
Sbjct: 26400 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26459

Query: 150   SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
             +ES +      +     SS     TG       ++    F V
Sbjct: 26460 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26501



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)

Query: 14   KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
            +K   GSG  K P+ A  + Q  A+P + +KE+K    ++    GS  +  C  S   S+
Sbjct: 4717 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 4774

Query: 66   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
                W K+G+ +    K + I   K     +L I    L+D+GEY C  + +LGN   ++
Sbjct: 4775 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 4829

Query: 126  NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
               +V     +  +    E   V    P+ +S
Sbjct: 4830 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 4861



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 16/60 (26%), Positives = 28/60 (46%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25351 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +TI
Sbjct: 26513 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5917 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5957



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)

Query: 57    CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 25217 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25273

Query: 117   KLGNDSASANITIVESNEI 135
               G DS+ A + +    E+
Sbjct: 25274 DYGEDSSYAELFVKGVREV 25292



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)

Query: 49    AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 14020 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14075

Query: 108   GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
             GEY     +  G       +T+++    + G P   E + VS+E
Sbjct: 14076 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 14115



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 6274 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6325

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
            I  A L D   Y   + +  G +  SA   IVE  ++
Sbjct: 6326 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6362



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6454 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6508

Query: 99   INKASLADSGEYMCKV 114
            I    L D  EY C V
Sbjct: 6509 IKDCRLDDECEYACGV 6524



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 8048 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8104

Query: 130  V 130
            +
Sbjct: 8105 I 8105



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 100  NKASLADSGEYMCKV 114
                L D GEY  KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 99   INKASLADSGEY 110
            I      D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)

Query: 69   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747

Query: 129  IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
            + +   ++  + +P   +G     E      ++ EGA T  +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 36/150 (24%), Positives = 55/150 (36%), Gaps = 26/150 (17%)

Query: 97   LRINKASLAD-SGEYMCKVISKLGNDSASANITIV-----------ESNEIITGMPASTE 144
            L I+K +  D  GEY+C+ ++  G  + SA +T+V           E  E+  G  A   
Sbjct: 4423 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFT 4482

Query: 145  GAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSN 204
               + S   +R      G     S   S   +S  +   E  +T  V+ GE         
Sbjct: 4483 -CEIQSAPNVRFQWFKAGREIYESDKCSIR-SSKYISSLEILRTQVVDCGE--------- 4531

Query: 205  PSRYLCKCQPGFTGARCTENVPMKVQNQEK 234
               Y CK    +    CT  + + V   EK
Sbjct: 4532 ---YTCKASNEYGSVSCTATLTVTVPGGEK 4558



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)

Query: 67   RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
            + +W KN   + +      I   ++ +   K+EL I KA   D G Y     ++LG+   
Sbjct: 9057 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 9116

Query: 124  SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
            + ++ + +      N  +T + A  E  Y++ ++P+
Sbjct: 9117 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9150



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E  +    V   E S  + ++R KWFKN   L   +  +++ +Q +     + 
Sbjct: 5563 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5614

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
                S+ D+ +   + +      S+ A +T++E +   TG
Sbjct: 5615 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5650



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11863 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921

Query: 130   VE 131
             ++
Sbjct: 11922 LD 11923



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)

Query: 35    LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
             +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   I+    
Sbjct: 26955 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 27012

Query: 94    KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 27013 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27048



 Score = 29.3 bits (64), Expect = 7.9
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070

Query: 100  NKASLADSGEY 110
                ++D+G+Y
Sbjct: 3071 PSTRMSDAGKY 3081


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26637 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26692

Query: 96    ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
              L I  AS++DSG+Y  K  +  G  SA+A++ ++      S E++  T    S +G++ 
Sbjct: 26693 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26751

Query: 149   SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
              S   +++S S + A+ SS +S+S +  + +
Sbjct: 26752 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26781



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)

Query: 20   SGKKPESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
            SGK   SA  +      P +K +++  E A G      CE  S   ++RF+WFK G E+ 
Sbjct: 4320 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIY 4378

Query: 79   RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              +K     I+     S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4379 ESDK---CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)

Query: 52   KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5182 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5235

Query: 112  CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
            C      G D   AN+T VE+  I    P      +V   +   I +S
Sbjct: 5236 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5278



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 14/109 (12%)

Query: 57   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
            CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 5898 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 5952

Query: 117  KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGA 163
                   S  +T++E   + T   A+ E   VS    I++   VS  GA
Sbjct: 5953 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGA 5994



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)

Query: 33   PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
            P  PP L   +K+     G  + L C  S  Y S    W++   ++       + +I  +
Sbjct: 893  PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 948

Query: 92   PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
             G + L I +A   DSG + C  +++ G  S S  + +  S E      A TE
Sbjct: 949  SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 3/135 (2%)

Query: 10   KGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK 69
            KG+G K         +S      P  P  LKE+K    A G   +       E +     
Sbjct: 3549 KGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VT 3607

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            WFK   +L          I    G     +N     DSG Y+CK  + LG  + +A + +
Sbjct: 3608 WFKENKQLC--TSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665

Query: 130  VESNEIITGMPASTE 144
            +  +  +T  P   +
Sbjct: 3666 LLEDTDMTDTPCKAK 3680



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)

Query: 25   ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
            E  AG   PA P  + +   Q+   G  +V  C+         + W K+G  L    +  
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1082

Query: 85   NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
             +   K+ G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1083 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)

Query: 36    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 26220 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26274

Query: 93    GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
             G  EL+IN  + +D GEY+C++  + G    +           +E ++ +  + +    +
Sbjct: 26275 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26334

Query: 150   SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
             +ES +      +     SS     TG       ++    F V
Sbjct: 26335 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26376



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)

Query: 14   KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
            +K   GSG  K P+ A  + Q  A+P + +KE+K    ++    GS  +  C  S   S+
Sbjct: 4592 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 4649

Query: 66   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
                W K+G+ +    K + I   K     +L I    L+D+GEY C  + +LGN   ++
Sbjct: 4650 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 4704

Query: 126  NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
               +V     +  +    E   V    P+ +S
Sbjct: 4705 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 4736



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 16/60 (26%), Positives = 28/60 (46%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25226 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25285



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +TI
Sbjct: 26388 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26444



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5792 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5832



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)

Query: 57    CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 25092 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25148

Query: 117   KLGNDSASANITIVESNEI 135
               G DS+ A + +    E+
Sbjct: 25149 DYGEDSSYAELFVKGVREV 25167



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)

Query: 49    AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 13895 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 13950

Query: 108   GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
             GEY     +  G       +T+++    + G P   E + VS+E
Sbjct: 13951 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 13990



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 6149 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6200

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
            I  A L D   Y   + +  G +  SA   IVE  ++
Sbjct: 6201 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6237



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6329 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6383

Query: 99   INKASLADSGEYMCKV 114
            I    L D  EY C V
Sbjct: 6384 IKDCRLDDECEYACGV 6399



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 70   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 7923 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 7979

Query: 130  V 130
            +
Sbjct: 7980 I 7980



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 100  NKASLADSGEYMCKV 114
                L D GEY  KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 99   INKASLADSGEY 110
            I      D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)

Query: 69   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747

Query: 129  IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
            + +   ++  + +P   +G     E      ++ EGA T  +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 36/150 (24%), Positives = 55/150 (36%), Gaps = 26/150 (17%)

Query: 97   LRINKASLAD-SGEYMCKVISKLGNDSASANITIV-----------ESNEIITGMPASTE 144
            L I+K +  D  GEY+C+ ++  G  + SA +T+V           E  E+  G  A   
Sbjct: 4298 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFT 4357

Query: 145  GAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSN 204
               + S   +R      G     S   S   +S  +   E  +T  V+ GE         
Sbjct: 4358 -CEIQSAPNVRFQWFKAGREIYESDKCSIR-SSKYISSLEILRTQVVDCGE--------- 4406

Query: 205  PSRYLCKCQPGFTGARCTENVPMKVQNQEK 234
               Y CK    +    CT  + + V   EK
Sbjct: 4407 ---YTCKASNEYGSVSCTATLTVTVPGGEK 4433



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)

Query: 67   RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
            + +W KN   + +      I   ++ +   K+EL I KA   D G Y     ++LG+   
Sbjct: 8932 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 8991

Query: 124  SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
            + ++ + +      N  +T + A  E  Y++ ++P+
Sbjct: 8992 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9025



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 39   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
            LK++ ++E  +    V   E S  + ++R KWFKN   L   +  +++ +Q +     + 
Sbjct: 5438 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5489

Query: 99   INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
                S+ D+ +   + +      S+ A +T++E +   TG
Sbjct: 5490 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5525



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 70    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11738 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11796

Query: 130   VE 131
             ++
Sbjct: 11797 LD 11798



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)

Query: 35    LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
             +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   I+    
Sbjct: 26830 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 26887

Query: 94    KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
              + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 26888 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 26923



 Score = 29.3 bits (64), Expect = 7.9
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 40   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070

Query: 100  NKASLADSGEY 110
                ++D+G+Y
Sbjct: 3071 PSTRMSDAGKY 3081


>gi|93102361 palladin [Homo sapiens]
          Length = 1106

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 23/221 (10%)

Query: 18  RGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNEL 77
           R S  +P SA     PA P  +++++SQE A GS++ L C  +    + R +WF  G EL
Sbjct: 255 RKSHPQPHSAL--HFPAAPRFIQKLRSQEVAEGSRVYLECRVTGN-PTPRVRWFCEGKEL 311

Query: 78  NRKNKPQNIKIQKKPGK-SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
           +  N P +I+I  + G    L I +A   D+G Y C   +  G+D+ SA + I       
Sbjct: 312 H--NTP-DIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFI------- 361

Query: 137 TGMPASTEGA-YVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGE 195
                  EGA    S+S      S  GA   +   T++   +      +   T  V    
Sbjct: 362 -------EGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVTTAVIQPL 414

Query: 196 CFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE 236
              V+ + +P+ YLC+   G T A        ++QN   AE
Sbjct: 415 SVPVQQVHSPTSYLCR-PDGTTTAYFPPVFTKELQNTAVAE 454


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 36/137 (26%), Positives = 66/137 (48%), Gaps = 20/137 (14%)

Query: 25   ESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 83
            + +  S  P++ P ++ E  S     G  L L C  + +  ++   W+K G  L  +++ 
Sbjct: 2618 QGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAI-ITWYKRGGSLPSRHQT 2676

Query: 84   QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAST 143
                       S LR+++ S+ADSGEY+C+         A+ NI  +E++ +I+  P++ 
Sbjct: 2677 HG---------SHLRLHQMSVADSGEYVCR---------ANNNIDALEASIVISVSPSAG 2718

Query: 144  EGAYVSSESPIRISVST 160
              +   S  PIRI  S+
Sbjct: 2719 SPSAPGSSMPIRIESSS 2735



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 20/137 (14%)

Query: 27   AAGSQSP---ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 83
            +AGS S    ++P R+ E  S   A G  L L C    + +  +  W K G  L   ++ 
Sbjct: 2716 SAGSPSAPGSSMPIRI-ESSSSHVAEGETLDLNCVVPGQ-AHAQVTWHKRGGSLPSHHQT 2773

Query: 84   QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAST 143
            +          S LR++  S ADSGEY+C+V+   G   AS  +TI  S      +PA  
Sbjct: 2774 RG---------SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAP- 2823

Query: 144  EGAYVSSESPIRISVST 160
                     PIRI  S+
Sbjct: 2824 -----GGAPPIRIEPSS 2835



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 22/135 (16%)

Query: 30   SQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 88
            S S A PP +K E  S     G  L L C  +   +  +  W++ G  L     P + ++
Sbjct: 2044 SASDASPPPVKIESSSPSVTEGQTLDLNCVVAGS-AHAQVTWYRRGGSL-----PPHTQV 2097

Query: 89   QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIV---ESNEIITGMPASTEG 145
                  S LR+ + S ADSGEY+C+V +  G   AS  ++++    S    T +P ST  
Sbjct: 2098 HG----SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR- 2152

Query: 146  AYVSSESPIRISVST 160
                   PIRI  S+
Sbjct: 2153 -------PIRIEPSS 2160



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 13/139 (9%)

Query: 26   SAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 85
            S + SQ  A P R+ E  S   A G  L L C  +S+ +     W+K G  L  +++   
Sbjct: 2525 SGSHSQGVAYPVRI-ESSSASLANGHTLDLNCLVASQ-APHTITWYKRGGSLPSRHQIVG 2582

Query: 86   IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEG 145
                     S LRI + + ADSGEY+C V +  G+   S  +TI  S    + +P+ +  
Sbjct: 2583 ---------SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS--SHVPSVSPP 2631

Query: 146  AYVSSESPIRISVSTEGAN 164
              + S SP  +   T   N
Sbjct: 2632 IRIESSSPTVVEGQTLDLN 2650



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 34/117 (29%), Positives = 49/117 (41%), Gaps = 10/117 (8%)

Query: 36   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
            PP   E  S   A G  L L+C    + +  +  W K G  L  +++             
Sbjct: 2827 PPIRIEPSSSRVAEGQTLDLKCVVPGQ-AHAQVTWHKRGGNLPARHQVHG---------P 2876

Query: 96   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSES 152
             LR+N+ S ADSGEY C+V    G   AS  +TI  S+      P   +  Y+ + S
Sbjct: 2877 LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASS 2933



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 10/89 (11%)

Query: 41   EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 100
            E  S + A G  L L C  + + +  +  W K G  L  +++            S LR+ 
Sbjct: 2442 ESSSSQVAEGQTLDLNCLVAGQ-AHAQVTWHKRGGSLPARHQVHG---------SRLRLL 2491

Query: 101  KASLADSGEYMCKVISKLGNDSASANITI 129
            + + ADSGEY+C+V+   G   AS  +TI
Sbjct: 2492 QVTPADSGEYVCRVVGSSGTQEASVLVTI 2520



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 20/126 (15%)

Query: 35   LPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 94
            +PP   E  S   A G  L L C  + + +  +  W+K G  L  +++ +          
Sbjct: 2244 IPPVRIESSSSTVAEGQTLDLSCVVAGQ-AHAQVTWYKRGGSLPARHQVRG--------- 2293

Query: 95   SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPI 154
            S L I +AS AD+G+Y+C+      ++   A+IT+      +TG   +       S  PI
Sbjct: 2294 SRLYIFQASPADAGQYVCR-----ASNGMEASITVT-----VTGTQGANLAYPAGSTQPI 2343

Query: 155  RISVST 160
            RI  S+
Sbjct: 2344 RIEPSS 2349



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 46/183 (25%), Positives = 71/183 (38%), Gaps = 37/183 (20%)

Query: 41   EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 100
            E  S   A G  L L C    + +  +  W K G  L  +++            S LR++
Sbjct: 2157 EPSSSHVAEGQTLDLNCVVPGQ-AHAQVTWHKRGGSLPARHQTHG---------SLLRLH 2206

Query: 101  KASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVST 160
            + + ADSGEY+C V+   G   AS  +TI E++ I   +P            P+RI    
Sbjct: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTI-EASVIPGPIP------------PVRI---- 2249

Query: 161  EGANTSSSTSTSTTGTSHLVKC-----AEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPG 215
                  SS+ST   G +  + C     A  + T+   GG       +     Y+ +  P 
Sbjct: 2250 -----ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPA 2304

Query: 216  FTG 218
              G
Sbjct: 2305 DAG 2307



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 12/112 (10%)

Query: 23   KPESAAGSQSPALP-PRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81
            +P S     +P L  P   E  S     G  L L C    + +  +  W+K G  L  ++
Sbjct: 2911 EPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQ-AHAQVTWYKRGGSLPARH 2969

Query: 82   KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG-NDSASANITIVES 132
            +            S+LR++  S ADSGEY+C+  S  G    AS  +T+  S
Sbjct: 2970 QTHG---------SQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPS 3012



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 10/95 (10%)

Query: 41   EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 100
            E  S + A G  L L C    + S  +  W K G  L  +++            S LR+ 
Sbjct: 2346 EPSSSQVAEGQTLDLNCVVPGQ-SHAQVTWHKRGGSLPVRHQTHG---------SLLRLY 2395

Query: 101  KASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
            +AS ADSGEY+C+V+       AS  +TI  +  +
Sbjct: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSV 2430



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 20/47 (42%), Positives = 25/47 (53%), Gaps = 7/47 (14%)

Query: 175  GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 221
            G SH   C ++    C NGG+C      S  S Y+C C  GFTG+RC
Sbjct: 3841 GISHCPTCRDRP---CQNGGQCHD----SESSSYVCVCPAGFTGSRC 3880



 Score = 35.8 bits (81), Expect = 0.084
 Identities = 36/153 (23%), Positives = 61/153 (39%), Gaps = 26/153 (16%)

Query: 31   QSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 90
            +SP     + E  S +  AG  + L+C        L F+W + G+ L  +   +N     
Sbjct: 3296 ESPPYATTVPEHASVQ--AGETVQLQCLAHGT-PPLTFQWSRVGSSLPGRATARN----- 3347

Query: 91   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 150
                  L   +A+  DSG Y C+V +K+G+  A A +       ++ G P S     + +
Sbjct: 3348 ----ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQL-------LVQGPPGSLPATSIPA 3396

Query: 151  ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCA 183
             S   + V+ +         T + G S    CA
Sbjct: 3397 GSTPTVQVTPQ-------LETKSIGASVEFHCA 3422



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 22/104 (21%), Positives = 41/104 (39%), Gaps = 10/104 (9%)

Query: 45   QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 104
            +  + G+ +   C   S+  + + +WFK G +L   +  Q+           LRI     
Sbjct: 3409 ETKSIGASVEFHCAVPSDRGT-QLRWFKEGGQLPPGHSVQD---------GVLRIQNLDQ 3458

Query: 105  ADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV 148
            +  G Y+C+     G   ASA + I     ++  +  S +   V
Sbjct: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV 3502



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 25/104 (24%), Positives = 42/104 (40%), Gaps = 14/104 (13%)

Query: 49   AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 108
            AG  + L C  +    S    W K G  L  + + +   I      + L I   + AD+G
Sbjct: 1969 AGRTVRLYCRAAG-VPSATITWRKEGGSLPPQARSERTDI------ATLLIPAITTADAG 2021

Query: 109  EYMCKVISKLGNDSASANITIVESNE-------IITGMPASTEG 145
             Y+C   S  G   A   + ++ +++       I +  P+ TEG
Sbjct: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEG 2065



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 32/134 (23%), Positives = 52/134 (38%), Gaps = 14/134 (10%)

Query: 29   GSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 88
            G+ +P  P    E       AG    LRC  +   +     W K  + L  +++ +    
Sbjct: 3205 GAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPLPWQHRLEG--- 3260

Query: 89   QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV 148
                    L I + +  DSG+Y+C   S  G+  A+  I  VES    T +P   E A V
Sbjct: 3261 ------DTLIIPRVAQQDSGQYICNATSPAGHAEATI-ILHVESPPYATTVP---EHASV 3310

Query: 149  SSESPIRISVSTEG 162
             +   +++     G
Sbjct: 3311 QAGETVQLQCLAHG 3324


>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
          Length = 355

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 3/100 (3%)

Query: 36  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
           PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +P  S
Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278

Query: 96  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
           +L     S  D G Y C   +KLG+ +AS  +  V++  +
Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTAL 318


>gi|45594240 limbic system-associated membrane protein [Homo
           sapiens]
          Length = 338

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 4/89 (4%)

Query: 36  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
           PP + E KS E+  G +  L+CE S+   +  F+W+++   +N  N    ++I+   G+S
Sbjct: 218 PPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKSTEGQS 273

Query: 96  ELRINKASLADSGEYMCKVISKLGNDSAS 124
            L +   +    G Y C   +KLG  +AS
Sbjct: 274 SLTVTNVTEEHYGNYTCVAANKLGVTNAS 302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.125    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,061,977
Number of Sequences: 37866
Number of extensions: 912420
Number of successful extensions: 6873
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 299
Number of HSP's that attempted gapping in prelim test: 4808
Number of HSP's gapped (non-prelim): 2237
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.