Search of human proteins with 7657335

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo
sapiens]
         (1295 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]     2633   0.0  
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]    2626   0.0  
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]    2615   0.0  
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]    2563   0.0  
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...  1671   0.0  
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...  1665   0.0  
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...  1655   0.0  
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...  1650   0.0  
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...  1587   0.0  
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...  1581   0.0  
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...  1581   0.0  
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...  1575   0.0  
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...  1550   0.0  
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...  1470   0.0  
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...   791   0.0  
gi|118600963 Nik related kinase [Homo sapiens]                        405   e-112
gi|145275208 myosin IIIA [Homo sapiens]                               310   8e-84
gi|134288915 myosin IIIB isoform 1 [Homo sapiens]                     292   2e-78
gi|134288892 myosin IIIB isoform 2 [Homo sapiens]                     292   2e-78
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   264   4e-70
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   262   2e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   257   4e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   257   4e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 256   8e-68
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 256   1e-67
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   253   8e-67
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      249   9e-66
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       249   9e-66
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   243   7e-64
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   242   1e-63

>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 2633 bits (6826), Expect = 0.0
 Identities = 1295/1295 (100%), Positives = 1295/1295 (100%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
            ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
            LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
            QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
            KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600

Query: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
            SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660

Query: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720
            DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH
Sbjct: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720

Query: 721  LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPP 780
            LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPP
Sbjct: 721  LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPP 780

Query: 781  KKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGT 840
            KKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGT
Sbjct: 781  KKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGT 840

Query: 841  QPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDY 900
            QPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDY
Sbjct: 841  QPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDY 900

Query: 901  QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNV 960
            QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNV
Sbjct: 901  QSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNV 960

Query: 961  NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR 1020
            NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR
Sbjct: 961  NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR 1020

Query: 1021 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG 1080
            RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG
Sbjct: 1021 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG 1080

Query: 1081 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL 1140
            HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL
Sbjct: 1081 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL 1140

Query: 1141 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV 1200
            KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV
Sbjct: 1141 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV 1200

Query: 1201 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK 1260
            NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK
Sbjct: 1201 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK 1260

Query: 1261 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Sbjct: 1261 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 2626 bits (6807), Expect = 0.0
 Identities = 1295/1303 (99%), Positives = 1295/1303 (99%), Gaps = 8/1303 (0%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
            ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
            LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
            QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
            KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600

Query: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
            SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660

Query: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720
            DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH
Sbjct: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720

Query: 721  LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA--------DFVLLKERT 772
            LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA        DFVLLKERT
Sbjct: 721  LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERT 780

Query: 773  LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH 832
            LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH
Sbjct: 781  LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH 840

Query: 833  DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP 892
            DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP
Sbjct: 841  DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP 900

Query: 893  SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV 952
            SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV
Sbjct: 901  SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV 960

Query: 953  RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1012
            RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 961  RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020

Query: 1013 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1072
            KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT
Sbjct: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080

Query: 1073 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1132
            VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL
Sbjct: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140

Query: 1133 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1192
            TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC
Sbjct: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200

Query: 1193 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1252
            YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260

Query: 1253 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Sbjct: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 2615 bits (6778), Expect = 0.0
 Identities = 1295/1332 (97%), Positives = 1295/1332 (97%), Gaps = 37/1332 (2%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
            ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
            LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
            QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
            KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600

Query: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
            SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660

Query: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
            DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA                         
Sbjct: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720

Query: 696  ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
                        SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 721  PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780

Query: 744  LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803
            LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 781  LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 840

Query: 804  EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 863
            EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 841  EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 900

Query: 864  ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 923
            ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 901  ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 960

Query: 924  QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 983
            QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 961  QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020

Query: 984  EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1043
            EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080

Query: 1044 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1103
            KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140

Query: 1104 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1163
            YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200

Query: 1164 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1223
            YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260

Query: 1224 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1283
            ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320

Query: 1284 FMTLNRNCIMNW 1295
            FMTLNRNCIMNW
Sbjct: 1321 FMTLNRNCIMNW 1332


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 2563 bits (6644), Expect = 0.0
 Identities = 1275/1332 (95%), Positives = 1275/1332 (95%), Gaps = 57/1332 (4%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
            ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
            LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
            QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
            KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL                  
Sbjct: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 582

Query: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
              QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 583  --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 640

Query: 661  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
            DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA                         
Sbjct: 641  DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 700

Query: 696  ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
                        SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 701  PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 760

Query: 744  LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803
            LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
Sbjct: 761  LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 820

Query: 804  EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 863
            EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
Sbjct: 821  EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH 880

Query: 864  ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 923
            ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
Sbjct: 881  ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY 940

Query: 924  QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 983
            QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
Sbjct: 941  QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1000

Query: 984  EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1043
            EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
Sbjct: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060

Query: 1044 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1103
            KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
Sbjct: 1061 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1120

Query: 1104 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1163
            YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
Sbjct: 1121 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1180

Query: 1164 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1223
            YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
Sbjct: 1181 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1240

Query: 1224 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1283
            ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1241 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1300

Query: 1284 FMTLNRNCIMNW 1295
            FMTLNRNCIMNW
Sbjct: 1301 FMTLNRNCIMNW 1312


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
            sapiens]
          Length = 1323

 Score = 1671 bits (4327), Expect = 0.0
 Identities = 899/1362 (66%), Positives = 1036/1362 (76%), Gaps = 106/1362 (7%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+EVEER+R+N+Q +SP    
Sbjct: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524

Query: 541  KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
            K  +   +P +P  S          ++TPPM RPV+PQ       + H V +K     + 
Sbjct: 525  KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577

Query: 598  RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
             SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P     
Sbjct: 578  ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626

Query: 653  -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704
             +  +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++
Sbjct: 627  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686

Query: 705  PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746
            P  E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL   
Sbjct: 687  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746

Query: 747  GNKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDE 800
              K KP++ R  +RP RPAD   L    +E  ++E  RP KK  DYSSSSEE ESSE++E
Sbjct: 747  PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 806

Query: 801  EEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----G 847
            E+GE    +G+    D P     G     +  +V  +  H +E  T     + G     G
Sbjct: 807  EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREG 864

Query: 848  TMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGD 899
            T++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++  SG 
Sbjct: 865  TLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGT 924

Query: 900  YQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVR 953
                G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +  + R
Sbjct: 925  EYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEAR 981

Query: 954  KGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1013
            K SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK
Sbjct: 982  KISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1041

Query: 1014 VYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTV 1073
            VY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TV
Sbjct: 1042 VYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITV 1101

Query: 1074 GDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLT 1133
            GD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLT
Sbjct: 1102 GDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLT 1161

Query: 1134 VEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCY 1193
            VEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+CY
Sbjct: 1162 VEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCY 1221

Query: 1194 EDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMH 1253
            EDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMH
Sbjct: 1222 EDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMH 1281

Query: 1254 KRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            KRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1282 KRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
            sapiens]
          Length = 1331

 Score = 1665 bits (4313), Expect = 0.0
 Identities = 898/1370 (65%), Positives = 1036/1370 (75%), Gaps = 114/1370 (8%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+EVEER+R+N+Q +SP    
Sbjct: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524

Query: 541  KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
            K  +   +P +P  S          ++TPPM RPV+PQ       + H V +K     + 
Sbjct: 525  KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577

Query: 598  RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
             SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P     
Sbjct: 578  ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626

Query: 653  -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704
             +  +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++
Sbjct: 627  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686

Query: 705  PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746
            P  E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL   
Sbjct: 687  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746

Query: 747  GNKAKPDDHR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMDYSSSSEE 792
              K KP++ R  +RP RPA +              L+E  ++E  RP KK  DYSSSSEE
Sbjct: 747  PAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEE 806

Query: 793  VESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPY 844
             ESSE++EE+GE    +G+    D P     G     +  +V  +  H +E  T     +
Sbjct: 807  SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSF 864

Query: 845  GG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPP 892
             G     GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  
Sbjct: 865  SGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTH 924

Query: 893  SKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLD 946
            S++  SG     G   +  K+SFT FVD  +YQ   + +          AL   E  R +
Sbjct: 925  SQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQE 981

Query: 947  QLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1005
            Q +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML
Sbjct: 982  QAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1041

Query: 1006 LDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVE 1065
            LDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVE
Sbjct: 1042 LDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVE 1101

Query: 1066 KKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPH 1125
            KKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H
Sbjct: 1102 KKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQH 1161

Query: 1126 RPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTD 1185
            +PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TD
Sbjct: 1162 KPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTD 1221

Query: 1186 GMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETG 1245
            GMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETG
Sbjct: 1222 GMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETG 1281

Query: 1246 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1282 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
            sapiens]
          Length = 1352

 Score = 1655 bits (4287), Expect = 0.0
 Identities = 899/1391 (64%), Positives = 1036/1391 (74%), Gaps = 135/1391 (9%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
             QE+EQ+R  E+   +RREEERR+AE EQEY                             
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475

Query: 452  KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
            KRKQLEEQRQ+ERLQRQL+QE  YL SLQ Q+Q+Q+          P ++KPLYHY  GM
Sbjct: 476  KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525

Query: 512  NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
            +P++KPAWA+EVEER+R+N+Q +SP    K  +   +P +P  S          ++TPPM
Sbjct: 526  SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584

Query: 569  QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
             RPV+PQ       + H V +K     +  SQS+ +QPT+ L+ F  + +          
Sbjct: 585  LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627

Query: 629  TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATAL--- 679
              S R  + RQNSDPTSE P P P      +  +W+R + + PPKVPQRT+SI+ AL   
Sbjct: 628  VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686

Query: 680  ----NTSGAGGSRPAQAVRASNPDLRRSDPGWER----------SDSVLPASH-----GH 720
                N S  G    +Q +RASNPDLRR++P  E           S S  P+S      G 
Sbjct: 687  NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 746

Query: 721  LP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KER 771
             P  QAGS ER RV  +SK + SPVL     K KP++ R  +RP RPAD   L    +E 
Sbjct: 747  QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELREL 806

Query: 772  TLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDT 823
             ++E  RP KK  DYSSSSEE ESSE++EE+GE    +G+    D P     G     + 
Sbjct: 807  RIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQ 866

Query: 824  DSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDV 875
             +V  +  H +E  T     + G     GT++++ T  E++   H+DSNG+    NLPD+
Sbjct: 867  YNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL 924

Query: 876  VQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGD 930
            VQ SHSP    TE     S  S++  SG     G   +  K+SFT FVD  +YQ   + +
Sbjct: 925  VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDE 981

Query: 931  S-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSE 984
                      AL   E  R +Q +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNSE
Sbjct: 982  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1041

Query: 985  ILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNK 1044
            ILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NK
Sbjct: 1042 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1101

Query: 1045 LRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVY 1104
            LRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+Y
Sbjct: 1102 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1161

Query: 1105 AWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIY 1164
            AWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIY
Sbjct: 1162 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1221

Query: 1165 IPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYI 1224
            IP HIQ  ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI
Sbjct: 1222 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1281

Query: 1225 CSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYF 1284
             SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+F
Sbjct: 1282 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1341

Query: 1285 MTLNRNCIMNW 1295
            MTLNRN +MNW
Sbjct: 1342 MTLNRNSMMNW 1352


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
          Length = 1360

 Score = 1650 bits (4273), Expect = 0.0
 Identities = 898/1399 (64%), Positives = 1036/1399 (74%), Gaps = 143/1399 (10%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
             QE+EQ+R  E+   +RREEERR+AE EQEY                             
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475

Query: 452  KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
            KRKQLEEQRQ+ERLQRQL+QE  YL SLQ Q+Q+Q+          P ++KPLYHY  GM
Sbjct: 476  KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525

Query: 512  NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
            +P++KPAWA+EVEER+R+N+Q +SP    K  +   +P +P  S          ++TPPM
Sbjct: 526  SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584

Query: 569  QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
             RPV+PQ       + H V +K     +  SQS+ +QPT+ L+ F  + +          
Sbjct: 585  LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627

Query: 629  TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATAL--- 679
              S R  + RQNSDPTSE P P P      +  +W+R + + PPKVPQRT+SI+ AL   
Sbjct: 628  VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686

Query: 680  ----NTSGAGGSRPAQAVRASNPDLRRSDPGWER----------SDSVLPASH-----GH 720
                N S  G    +Q +RASNPDLRR++P  E           S S  P+S      G 
Sbjct: 687  NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 746

Query: 721  LP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL-------- 767
             P  QAGS ER RV  +SK + SPVL     K KP++ R  +RP RPA +          
Sbjct: 747  QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTA 806

Query: 768  ----LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP----- 815
                L+E  ++E  RP KK  DYSSSSEE ESSE++EE+GE    +G+    D P     
Sbjct: 807  LAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPT 866

Query: 816  GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT 870
            G     +  +V  +  H +E  T     + G     GT++++ T  E++   H+DSNG+ 
Sbjct: 867  GAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 924

Query: 871  ---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGI 922
               NLPD+VQ SHSP    TE     S  S++  SG     G   +  K+SFT FVD  +
Sbjct: 925  GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRV 981

Query: 923  YQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRK 976
            YQ   + +          AL   E  R +Q +  + RK SVVNVNPTN R HS+TPEIRK
Sbjct: 982  YQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRK 1041

Query: 977  YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI 1036
            YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+
Sbjct: 1042 YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV 1101

Query: 1037 TISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIA 1096
            TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIA
Sbjct: 1102 TISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIA 1161

Query: 1097 LKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVD 1156
            LK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS  GFH +DVD
Sbjct: 1162 LKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVD 1221

Query: 1157 SGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGE 1216
            SGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGE
Sbjct: 1222 SGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGE 1281

Query: 1217 MPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS 1276
            MPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS
Sbjct: 1282 MPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS 1341

Query: 1277 GGSSQVYFMTLNRNCIMNW 1295
            GGSSQV+FMTLNRN +MNW
Sbjct: 1342 GGSSQVFFMTLNRNSMMNW 1360


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
            sapiens]
          Length = 1268

 Score = 1587 bits (4108), Expect = 0.0
 Identities = 872/1359 (64%), Positives = 997/1359 (73%), Gaps = 155/1359 (11%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
             Q       +Q+Q                           R VE++         PL   
Sbjct: 476  HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492

Query: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
            K G +                     P ++P   +E PH       V +K     +  SQ
Sbjct: 493  KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525

Query: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
            S+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P      + 
Sbjct: 526  SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574

Query: 655  PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707
             +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++P  
Sbjct: 575  SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634

Query: 708  ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749
            E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL     K
Sbjct: 635  ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694

Query: 750  AKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG 803
             KP++ R  +RP RPAD   L    +E  ++E  RP KK  DYSSSSEE ESSE++EE+G
Sbjct: 695  VKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDG 754

Query: 804  EGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMV 850
            E    +G+    D P     G     +  +V  +  H +E  T     + G     GT++
Sbjct: 755  ESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLM 812

Query: 851  VQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQS 902
            ++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++  SG    
Sbjct: 813  IRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYG 872

Query: 903  RGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGS 956
             G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +  + RK S
Sbjct: 873  MG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKIS 929

Query: 957  VVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYG 1016
            VVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 
Sbjct: 930  VVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYN 989

Query: 1017 LIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDM 1076
            LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+
Sbjct: 990  LINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDL 1049

Query: 1077 EGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEE 1136
            EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEE
Sbjct: 1050 EGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEE 1109

Query: 1137 GQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDE 1196
            GQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+CYEDE
Sbjct: 1110 GQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDE 1169

Query: 1197 GVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRA 1256
            GVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRA
Sbjct: 1170 GVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRA 1229

Query: 1257 QRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            QRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1230 QRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
            sapiens]
          Length = 1276

 Score = 1581 bits (4094), Expect = 0.0
 Identities = 871/1367 (63%), Positives = 997/1367 (72%), Gaps = 163/1367 (11%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475

Query: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
             Q       +Q+Q                           R VE++         PL   
Sbjct: 476  HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492

Query: 541  KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
            K G +                     P ++P   +E PH       V +K     +  SQ
Sbjct: 493  KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525

Query: 601  SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
            S+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P      + 
Sbjct: 526  SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574

Query: 655  PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707
             +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++P  
Sbjct: 575  SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634

Query: 708  ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749
            E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL     K
Sbjct: 635  ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694

Query: 750  AKPDDHR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMDYSSSSEEVES 795
             KP++ R  +RP RPA +              L+E  ++E  RP KK  DYSSSSEE ES
Sbjct: 695  VKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESES 754

Query: 796  SEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG- 846
            SE++EE+GE    +G+    D P     G     +  +V  +  H +E  T     + G 
Sbjct: 755  SEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGS 812

Query: 847  ----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD 895
                GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++
Sbjct: 813  ISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQE 872

Query: 896  -GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQ 949
              SG     G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +
Sbjct: 873  MDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 929

Query: 950  Y-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1008
              + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR
Sbjct: 930  LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 989

Query: 1009 SGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQ 1068
            SGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQ
Sbjct: 990  SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1049

Query: 1069 GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPL 1128
            GW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PL
Sbjct: 1050 GWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPL 1109

Query: 1129 LVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGME 1188
            LVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGME
Sbjct: 1110 LVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGME 1169

Query: 1189 MLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLD 1248
            ML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLD
Sbjct: 1170 MLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLD 1229

Query: 1249 GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1230 GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1276


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
            sapiens]
          Length = 1297

 Score = 1581 bits (4093), Expect = 0.0
 Identities = 868/1363 (63%), Positives = 1000/1363 (73%), Gaps = 134/1363 (9%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE-QRQSERLQRQLQQEHAYLKSL 479
             QE+EQ+R  E+   +RREEERR+AE EQEY R+QLEE QRQ E LQ+QL  E A L   
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475

Query: 480  QQQQQQQQLQKQQQQQLLPGDRK---PLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
            +++Q ++Q Q ++ Q+ L  +R     L H  +   P +K                   P
Sbjct: 476  KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK------------------KP 517

Query: 537  LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
            L   K G +                     P ++P   +E PH       V +K     +
Sbjct: 518  LYHYKEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPAL 550

Query: 597  PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP---- 652
              SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P    
Sbjct: 551  TASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIE 599

Query: 653  --NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRS 703
              +  +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR+
Sbjct: 600  KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRT 659

Query: 704  DPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS- 745
            +P  E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL  
Sbjct: 660  EPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPH 719

Query: 746  PGNKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDD 799
               K KP++ R  +RP RPAD   L    +E  ++E  RP KK  DYSSSSEE ESSE++
Sbjct: 720  EPAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEE 779

Query: 800  EEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG----- 846
            EE+GE    +G+    D P     G     +  +V  +  H +E  T     + G     
Sbjct: 780  EEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISRE 837

Query: 847  GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSG 898
            GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++  SG
Sbjct: 838  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 897

Query: 899  DYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DV 952
                 G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +  + 
Sbjct: 898  TEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEA 954

Query: 953  RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1012
            RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 955  RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1014

Query: 1013 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1072
            KVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW T
Sbjct: 1015 KVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWIT 1074

Query: 1073 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1132
            VGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDL
Sbjct: 1075 VGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDL 1134

Query: 1133 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1192
            TVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+C
Sbjct: 1135 TVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVC 1194

Query: 1193 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1252
            YEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1195 YEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFM 1254

Query: 1253 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            HKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1255 HKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
            sapiens]
          Length = 1305

 Score = 1575 bits (4079), Expect = 0.0
 Identities = 867/1371 (63%), Positives = 1000/1371 (72%), Gaps = 142/1371 (10%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417

Query: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE-QRQSERLQRQLQQEHAYLKSL 479
             QE+EQ+R  E+   +RREEERR+AE EQEY R+QLEE QRQ E LQ+QL  E A L   
Sbjct: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475

Query: 480  QQQQQQQQLQKQQQQQLLPGDRK---PLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
            +++Q ++Q Q ++ Q+ L  +R     L H  +   P +K                   P
Sbjct: 476  KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK------------------KP 517

Query: 537  LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
            L   K G +                     P ++P   +E PH       V +K     +
Sbjct: 518  LYHYKEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPAL 550

Query: 597  PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP---- 652
              SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P    
Sbjct: 551  TASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIE 599

Query: 653  --NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRS 703
              +  +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR+
Sbjct: 600  KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRT 659

Query: 704  DPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS- 745
            +P  E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL  
Sbjct: 660  EPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPH 719

Query: 746  PGNKAKPDDHR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMDYSSSSE 791
               K KP++ R  +RP RPA +              L+E  ++E  RP KK  DYSSSSE
Sbjct: 720  EPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSE 779

Query: 792  EVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPP 843
            E ESSE++EE+GE    +G+    D P     G     +  +V  +  H +E  T     
Sbjct: 780  ESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADS 837

Query: 844  YGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSP 891
            + G     GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S 
Sbjct: 838  FSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVST 897

Query: 892  PSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRL 945
             S++  SG     G   +  K+SFT FVD  +YQ   + +          AL   E  R 
Sbjct: 898  HSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQ 954

Query: 946  DQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM 1004
            +Q +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM
Sbjct: 955  EQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM 1014

Query: 1005 LLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEV 1064
            LLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEV
Sbjct: 1015 LLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEV 1074

Query: 1065 EKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLP 1124
            EKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL 
Sbjct: 1075 EKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQ 1134

Query: 1125 HRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNT 1184
            H+PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP T
Sbjct: 1135 HKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKT 1194

Query: 1185 DGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVET 1244
            DGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVET
Sbjct: 1195 DGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1254

Query: 1245 GHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
            GHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1255 GHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 2 [Homo sapiens]
          Length = 1320

 Score = 1550 bits (4014), Expect = 0.0
 Identities = 866/1385 (62%), Positives = 982/1385 (70%), Gaps = 155/1385 (11%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNPPPRLKSKKWSKKF  FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
            QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++   E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 360  QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
            QENK  SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 420  KLQEKEQQRR-------LEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
            + QE+EQ+RR       LE+++  R+EEE        +R+ EREQEY R+QLEE+     
Sbjct: 421  RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 460  ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
                                    RQ+ERLQRQLQQE AYL SLQ   ++   Q  QQ  
Sbjct: 481  VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540

Query: 496  LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
                +R KP +H         PAD+   AREVE+R R     +SP A+SK      EPP+
Sbjct: 541  PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596

Query: 552  PQASPGPPGPLSQT--PPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRN 609
            P  S       S++  P +QRP EPQ        +H   LK   +PV RS S  D   + 
Sbjct: 597  PSRSESFSNGNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSRSHSFSDPSPKF 651

Query: 610  LAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKV 668
                  S DP          P +R  V+ Q+SD  SE P P+    AW R D+ E PP+V
Sbjct: 652  AHHHLRSQDP---------CPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRV 700

Query: 669  PQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP--------- 715
            P RT+S +  L+   +     G + +QA + ++         WER + ++P         
Sbjct: 701  PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 760

Query: 716  -ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPADF 765
             ++ G  P      Q+GS ER RV  SSK + SP     N  K P+D +   RP +PA  
Sbjct: 761  SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 820

Query: 766  V----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRDTPGG 817
            V    L KE    E  RPP K  DYSSSSEE     E  +D E+EG      G  DT   
Sbjct: 821  VDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 880

Query: 818  RS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLP 873
             S    +G+T+SV TM+VHD  E      P   GT++V++T                   
Sbjct: 881  SSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA---------------- 924

Query: 874  DVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIP 933
                                        S  L K    SSFT F+D  + Q   S  +  
Sbjct: 925  ----------------------------SSTLQKHKSSSSFTPFIDPRLLQISPSSGTT- 955

Query: 934  ITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAAL 990
            +T++VG   +G R + ++ D  RKGSVVNVNPTNTR  S+TPEIRKYKKRFNSEILCAAL
Sbjct: 956  VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAAL 1015

Query: 991  WGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYL 1050
            WGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++KLRVYYL
Sbjct: 1016 WGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYL 1075

Query: 1051 SWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKP 1110
            SWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAWAPKP
Sbjct: 1076 SWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKP 1135

Query: 1111 YHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ 1170
            YHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P HIQ
Sbjct: 1136 YHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQ 1195

Query: 1171 SQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIM 1230
              I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQ M
Sbjct: 1196 CSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTM 1255

Query: 1231 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRN 1290
            GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL R 
Sbjct: 1256 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRT 1315

Query: 1291 CIMNW 1295
             +++W
Sbjct: 1316 SLLSW 1320


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 3 [Homo sapiens]
          Length = 1212

 Score = 1470 bits (3806), Expect = 0.0
 Identities = 816/1334 (61%), Positives = 938/1334 (70%), Gaps = 161/1334 (12%)

Query: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
            M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
            ALFLIPRNPPPRLKSKKWSKKF  FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
            QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++   E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 360  QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
            QENK  SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 420  KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
            + QE+EQ+RR         +EE+R+ E E E +RK+ EE+R++E  +R++++E  Y++  
Sbjct: 421  RQQEREQRRR--------EQEEKRRLE-ELERRRKEEEERRRAEEEKRRVEREQEYIR-- 469

Query: 480  QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
            +Q +++Q+  +  QQQLL      L+ + R                              
Sbjct: 470  RQLEEEQRHLEVLQQQLLQEQAMLLHDHRR------------------------------ 499

Query: 540  SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRS 599
                      P PQ S  PP      PP Q   +P          H    K +  P  R+
Sbjct: 500  ----------PHPQHSQQPP------PPQQERSKPS--------FHAPEPKAHYEPADRA 535

Query: 600  QSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVR 659
            + ++D+  +   + P +             PS   +    NS+            PA  R
Sbjct: 536  REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH---------PALQR 586

Query: 660  PDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP 715
            P   A P+VP RT+S +  L+   +     G + +QA + ++         WER + ++P
Sbjct: 587  P---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVP 643

Query: 716  ----------ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS- 757
                      ++ G  P      Q+GS ER RV  SSK + SP     N  K P+D +  
Sbjct: 644  RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEV 703

Query: 758  -RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPA 808
             RP +PA  V    L KE    E  RPP K  DYSSSSEE     E  +D E+EG     
Sbjct: 704  FRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADEST 763

Query: 809  EGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHA 864
             G  DT    S    +G+T+SV TM+VHD  E      P   GT++V++T          
Sbjct: 764  SGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA------- 816

Query: 865  DSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQ 924
                                                 S  L K    SSFT F+D  + Q
Sbjct: 817  -------------------------------------SSTLQKHKSSSSFTPFIDPRLLQ 839

Query: 925  PGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRF 981
               S  +  +T++VG   +G R + ++ D  RKGSVVNVNPTNTR  S+TPEIRKYKKRF
Sbjct: 840  ISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 898

Query: 982  NSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGK 1041
            NSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK
Sbjct: 899  NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 958

Query: 1042 RNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSV 1101
            ++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSV
Sbjct: 959  KDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSV 1018

Query: 1102 EVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSY 1161
            EVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ Y
Sbjct: 1019 EVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVY 1078

Query: 1162 DIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSV 1221
            DIY+P HIQ  I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSV
Sbjct: 1079 DIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSV 1138

Query: 1222 AYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ 1281
            AYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ
Sbjct: 1139 AYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ 1198

Query: 1282 VYFMTLNRNCIMNW 1295
            VYFMTL R  +++W
Sbjct: 1199 VYFMTLGRTSLLSW 1212


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score =  791 bits (2044), Expect = 0.0
 Identities = 418/566 (73%), Positives = 465/566 (82%), Gaps = 33/566 (5%)

Query: 1   MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
           M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1   MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61  DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
           DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61  DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
           KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
           TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
           ALFLIPRNPPPRLKSKKWSKKF  FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
           QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++   E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
           QENK  SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 420 KLQEKEQ-------QRRLEDMQALRR--------EEERRQAEREQEYKRKQL-EEQRQSE 463
           + QE+EQ       +RRLE+++  R+        EEE+R+ EREQEY R+QL EEQR  E
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 464 RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQQQLLPGDR--KPLYHYGRGMNPADKPA 518
            LQ+QL QE A L    ++   Q  QQ    QQ++  P     +P  HY     PAD+  
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHY----EPADR-- 534

Query: 519 WAREVEERTRMN----KQQNSPLAKS 540
            AREV  RT        +++SPL  S
Sbjct: 535 -AREVPVRTTSRSPVLSRRDSPLQGS 559



 Score =  718 bits (1853), Expect = 0.0
 Identities = 455/984 (46%), Positives = 570/984 (57%), Gaps = 142/984 (14%)

Query: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQK---------EERRRVEE 410
            +  S  + LK      Q  +R     +K H+   R++R E+ +         EE   V E
Sbjct: 276  QRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPE 335

Query: 411  QQRR---------EREQRKLQEKEQQRRLEDMQALRREE--ERRQAEREQEYKRKQLEEQ 459
            Q+           E   R+   + QQ   E  +ALRR++  + +Q   ++EYKR+ L E+
Sbjct: 336  QEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAER 395

Query: 460  RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAW 519
            ++  R+++Q +Q     +  +++++ ++ Q+++Q++    +++ L    R     ++   
Sbjct: 396  QK--RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE--- 450

Query: 520  AREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPH 579
             R  EE  R  +++   + +           + Q        L Q   M           
Sbjct: 451  RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQ-------LLQEQAML---------- 493

Query: 580  KSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDP-DPAIPAPTATPSARGAVIR 638
              L  HR P   ++   P  Q  + +P+ +     A ++P D A   P  T S R  V+ 
Sbjct: 494  --LHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTS-RSPVLS 550

Query: 639  QNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP-QRTSSIATALNTSGAGGSRPAQAVRASN 697
            +   P  +G G   +        +   P++  +R   +     +  + GS  + +   S+
Sbjct: 551  RRDSPL-QGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSH 609

Query: 698  PDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHR 756
            P                        Q+GS ER RV  SSK + SP     N  K P+D +
Sbjct: 610  PG----------------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKK 647

Query: 757  S--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGG 806
               RP +PA  V    L KE    E  RPP K  DYSSSSEE     E  +D E+EG   
Sbjct: 648  EVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADE 707

Query: 807  PAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLL 862
               G  DT    S    +G+T+SV TM+VHD  E      P   GT++V++T        
Sbjct: 708  STSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA----- 762

Query: 863  HADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGI 922
                                                   S  L K    SSFT F+D  +
Sbjct: 763  ---------------------------------------SSTLQKHKSSSSFTPFIDPRL 783

Query: 923  YQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKK 979
             Q   S  +  +T++VG   +G R + ++ D  RKGSVVNVNPTNTR  S+TPEIRKYKK
Sbjct: 784  LQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK 842

Query: 980  RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITIS 1039
            RFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TIS
Sbjct: 843  RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS 902

Query: 1040 GKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKS 1099
            GK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKS
Sbjct: 903  GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS 962

Query: 1100 SVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGN 1159
            SVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+
Sbjct: 963  SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS 1022

Query: 1160 SYDIYIPVH--------IQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVV 1211
             YDIY+P H        IQ  I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVV
Sbjct: 1023 VYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVV 1082

Query: 1212 LQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFF 1271
            LQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFF
Sbjct: 1083 LQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFF 1142

Query: 1272 ASVRSGGSSQVYFMTLNRNCIMNW 1295
            ASVRSGGSSQVYFMTL R  +++W
Sbjct: 1143 ASVRSGGSSQVYFMTLGRTSLLSW 1166


>gi|118600963 Nik related kinase [Homo sapiens]
          Length = 1582

 Score =  405 bits (1041), Expect = e-112
 Identities = 244/601 (40%), Positives = 340/601 (56%), Gaps = 74/601 (12%)

Query: 1   MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
           M  P   R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +
Sbjct: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60

Query: 61  ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120

Query: 97  NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156
              QLW+VME C AGSVTD+V+ T   +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180

Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240

Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R   P +KS  WS+KF +F++ C IK +L 
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300

Query: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327
           RP +  +L+ PF+RD   ER V   L  H   I + R+K+G     E+EE  + +Y+   
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360

Query: 328 EEDDS--------------------HGEEGEP-----------SSIMNVPGESTLRREFL 356
               S                    HGE  +P            ++  + G +   R F+
Sbjct: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAA---RVFM 417

Query: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
            LQ  + S  + LK Q Q  Q+ Q      +     Q Q + +  K  + +++   R  R
Sbjct: 418 PLQALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRR 473

Query: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
             R L   + Q R   +  ++ +  ++Q  + Q  + + L++  +  + Q Q+ ++    
Sbjct: 474 AARVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQG 533

Query: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
           ++ +QQQ+  Q+ +Q+ +Q    ++  +    +   PA     A E  E  R+N Q   P
Sbjct: 534 QAPEQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLP 590

Query: 537 L 537
           L
Sbjct: 591 L 591



 Score =  282 bits (721), Expect = 2e-75
 Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)

Query: 775  EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 831
            EAP  P+ +   D S   +  + S   EE   G G    +R   G  +  D  ++     
Sbjct: 986  EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045

Query: 832  HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 889
            H     +  +   G G   V RT EE   L L+ + N   T+ P + +P+    E  + +
Sbjct: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105

Query: 890  SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 936
                 + S    S     AP   S    +     Q              G S D+   +A
Sbjct: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165

Query: 937  LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 996
            ++      + +     ++ S VNVNP       + P I  Y+K F SEI C +LWGVNLL
Sbjct: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223

Query: 997  VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1056
            +GT + L L+DRSG+  +  LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283

Query: 1057 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1108
            IL+NDPE +++Q            +  + GC H+ V+++E   ++ IALKSS+ +YAWAP
Sbjct: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343

Query: 1109 K---------------------------------------PYHKF---------MAFKSF 1120
            K                                       P ++F         +  K F
Sbjct: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403

Query: 1121 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1180
              L H+P+ VDL +   +RLK+ + S+ G+H +D +S    D+ +P +    I P  II 
Sbjct: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463

Query: 1181 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1240
            LP+  G+ M+L +  E + V    ++ K ++  W ++P+S+A+ C+ +  GWG+KAIE+R
Sbjct: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523

Query: 1241 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1289
            S+++  L+     +  ++L+FLC R DK+FF S      S+VYFMTL +
Sbjct: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)

Query: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399
           L R+ LR    N +NS+ L   Q L           Q +Q R+ ++ +  L     +R+ 
Sbjct: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700

Query: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459
            ++   +     ++ E    + + + +QRR ED+   + EEE RQ ++++E +    +E 
Sbjct: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759

Query: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511
             S + + Q++    Y+ +       ++++ Q++   +P ++   +H            +
Sbjct: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813

Query: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553
             A KP   R+   + R N         ++ SP+   +  S+ P   I Q
Sbjct: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863


>gi|145275208 myosin IIIA [Homo sapiens]
          Length = 1616

 Score =  310 bits (793), Expect = 8e-84
 Identities = 153/273 (56%), Positives = 189/273 (69%), Gaps = 4/273 (1%)

Query: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHH 79
           DP+  +E+ E +G GTYG+V+K  + K GQ AA+K++D   D +EEI+ E N+LK  S H
Sbjct: 16  DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75

Query: 80  RNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGNALKEDCIAYICREI 137
            N+  +YG + KK    N D+LWLV+E C  GSVTDLVK    +G  + E  IAYI  E 
Sbjct: 76  PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134

Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L GL HLH +K IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194

Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
           EVIAC++  D TYD R D WSLGITAIE+ +G PPL D+HPMRALF IPRNPPP+L+  +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254

Query: 258 -WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
            WS +F DFI  CL K Y  RP   +LL+  FI
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287


>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
          Length = 1314

 Score =  292 bits (747), Expect = 2e-78
 Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)

Query: 13  IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
           + L +L DP   +E++E +G GTYG+VYK  + + G LAA+K++D   D +EEI+ E N+
Sbjct: 15  LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74

Query: 73  LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
           L+   +H N+  +YG F K        QLWLV+E C  GSVT+LVK     G  L E  I
Sbjct: 75  LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133

Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
           +YI    L GL HLH +++IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193

Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
           TP+WMAPEVIAC++  D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253

Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
           P  L  +KW ++F  FI  CLIK +  RP    LL  PFI+         ++Q+   L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313

Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
             H +   K R E+  T   Y   + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340


>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
          Length = 1341

 Score =  292 bits (747), Expect = 2e-78
 Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)

Query: 13  IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
           + L +L DP   +E++E +G GTYG+VYK  + + G LAA+K++D   D +EEI+ E N+
Sbjct: 15  LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74

Query: 73  LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
           L+   +H N+  +YG F K        QLWLV+E C  GSVT+LVK     G  L E  I
Sbjct: 75  LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133

Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
           +YI    L GL HLH +++IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193

Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
           TP+WMAPEVIAC++  D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253

Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
           P  L  +KW ++F  FI  CLIK +  RP    LL  PFI+         ++Q+   L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313

Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
             H +   K R E+  T   Y   + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  264 bits (675), Expect = 4e-70
 Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)

Query: 6   PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
           P R L  +D  +L + P  +F+++E +G G+YG VYK  H +TGQ+ AIK + V  D +E
Sbjct: 10  PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69

Query: 65  EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
            IK+   M +  S H  +  YYG++ K +       LW+VME+CGAGSV+D+++  +   
Sbjct: 70  IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120

Query: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
           L ED IA I +  L+GL +LH  + IHRDIK  N+LL      KL DFGV+ QL  T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180

Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
           RNT IGTP+WMAPEVI      +  Y+  +DIWSLGITAIEMAEG PP  D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235

Query: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
           IP NPPP   K + WS  F DF+  CL+K+   R    QLL+ PF+R   + + V I L+
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291

Query: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
           D I+ +   + +++E++      ++E++S  +E +  +++   G+
Sbjct: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  262 bits (669), Expect = 2e-69
 Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)

Query: 14  DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
           DLS  R+P   FEL++ +G+GTYG VYK R+V TG+LAAIKV+ +   E+  + Q+  ++
Sbjct: 6   DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64

Query: 74  KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
            K   H NI  Y+G+++++      D+LW+ MEFCG GS+ D+   T    L E  IAY+
Sbjct: 65  MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116

Query: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
            RE L+GL +LH+   +HRDIKG N+LLT+N  VKL DFGVSAQ+  T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176

Query: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
           WMAPEV A +      Y+   D+W++GITAIE+AE  PP+ D+HPMRALFL+ ++   PP
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234

Query: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
           +LK K KWS  F  F+   L K    RP  E+LL+ PF+    T R + I+L D ++   
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292

Query: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
                      ++S   + DD      +P  ++ VP    ST R       +E K+ SE 
Sbjct: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331

Query: 369 LKQQQQLQQQQQRDPEAH 386
              Q +     +++ E H
Sbjct: 332 TFGQVKFDPPLRKETEPH 349


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  257 bits (657), Expect = 4e-68
 Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)

Query: 5   APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
           AP R   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+ 
Sbjct: 3   APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59

Query: 64  EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
             I+QEI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T   
Sbjct: 60  SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110

Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
            L E  IAY+CRE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ 
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170

Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
           +R +FIGTPYWMAPEV A ++N    Y+   DIW++GITAIE+ E  PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228

Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
           L+ ++   PP+LK K KWS  F +F+   L K    RP  E+LL   F+      R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288

Query: 301 QLKDHID 307
           +L D ++
Sbjct: 289 ELLDKVN 295


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  257 bits (657), Expect = 4e-68
 Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)

Query: 5   APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
           AP R   DI     R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +   D+ 
Sbjct: 3   APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59

Query: 64  EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
             I+QEI M+K+  H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T   
Sbjct: 60  SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110

Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
            L E  IAY+CRE L+GLA+LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ 
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170

Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
           +R +FIGTPYWMAPEV A ++N    Y+   DIW++GITAIE+ E  PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228

Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
           L+ ++   PP+LK K KWS  F +F+   L K    RP  E+LL   F+      R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288

Query: 301 QLKDHID 307
           +L D ++
Sbjct: 289 ELLDKVN 295


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  256 bits (655), Expect = 8e-68
 Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)

Query: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74

Query: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E  IA I REI
Sbjct: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124

Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH+ + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184

Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
           EVI       + YD+++DIWSLGITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239

Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
            SK F +F++ CL K    RP  ++LLK  FI     +     +L D     R KR + E
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293

Query: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346
               E S  + + D   E+GE   I   P
Sbjct: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  256 bits (653), Expect = 1e-67
 Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)

Query: 4   PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
           PAP   L  +   +L + P  +F+++E +G G+YG V+K  H ++GQ+ AIK + V  D 
Sbjct: 5   PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64

Query: 63  EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
           +E IK EI+++++      +  YYG++ K +       LW+VME+CGAGSV+D+++  + 
Sbjct: 65  QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115

Query: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
             L ED IA I +  L+GL +LH  + IHRDIK  N+LL      KL DFGV+ QL  T+
Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175

Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
            +RNT IGTP+WMAPEVI      +  Y+  +DIWSLGIT+IEMAEG PP  D+HPMRA+
Sbjct: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230

Query: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
           F+IP NPPP   K + WS  F DF+  CL+K    R    QLL+ PFI++      +R  
Sbjct: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290

Query: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
           + +   I   R +  ++E  E E +  E+E DSH
Sbjct: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  253 bits (646), Expect = 8e-67
 Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)

Query: 18  LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
           + DP  +F  +E +G G++G+V+KG   +T Q+ AIK++D+   EDE E+I+QEI +L +
Sbjct: 17  IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76

Query: 76  YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
                 +  YYG+++K S      +LW++ME+ G GS  DL++        E  IA + +
Sbjct: 77  CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126

Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
           EIL+GL +LH+ K IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186

Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
           APEVI       + YD ++DIWSLGITAIE+A+G PP  DMHPMR LFLIP+N PP L  
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241

Query: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
             ++K F +FID CL K    RP  ++LLK  FI     +     +L D   R + +   
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300

Query: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
            +E++ E S SE    E+++H E        + +P  + N   +  ++            
Sbjct: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360

Query: 355 FLRLQQENKSNSEALKQQQQLQQ 377
           F  L+Q++++N+   +  ++L++
Sbjct: 361 FAELKQQDENNASRNQAIEELEK 383


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  249 bits (637), Expect = 9e-66
 Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)

Query: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
           DP  +F  +E +G G++G+V+KG   +T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 19  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
               +  YYG+++K      D +LW++ME+ G GS  DL++      L E  IA I REI
Sbjct: 79  SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128

Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH+ K IHRDIK  NVLL+E+ EVKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188

Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
           EVI       + YD ++DIWSLGITAIE+A G PP  ++HPM+ LFLIP+N PP L+   
Sbjct: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242

Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
           +SK   +F++ CL K    RP  ++LLK  FI     +     +L   IDR ++ + E+ 
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299

Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
             +     S+ E D     G  S
Sbjct: 300 HDDSSSEDSDAETDGQASGGSDS 322


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  249 bits (637), Expect = 9e-66
 Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)

Query: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
           DP  +F  +E +G G++G+V+KG   +T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 31  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90

Query: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
               +  YYG+++K      D +LW++ME+ G GS  DL++      L E  IA I REI
Sbjct: 91  SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140

Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH+ K IHRDIK  NVLL+E+ EVKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200

Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
           EVI       + YD ++DIWSLGITAIE+A G PP  ++HPM+ LFLIP+N PP L+   
Sbjct: 201 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 254

Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
           +SK   +F++ CL K    RP  ++LLK  FI     +     +L   IDR ++ + E+ 
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 311

Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
             +     S+ E D     G  S
Sbjct: 312 HDDSSSEDSDAETDGQASGGSDS 334


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  243 bits (621), Expect = 7e-64
 Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)

Query: 17  ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
           +L+DP   FEL++ VG GTYG VYK R   T +LAA+K++ +   D+   ++QEI +L++
Sbjct: 8   SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67

Query: 76  YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
              H N+  Y G++++      +D+LW+ MEFCG GS+ ++   T    L+E  IAY+CR
Sbjct: 68  -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118

Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
           E L+GL HLH+   IHRDIKG N+LLT   +VKL DFGVS +L  +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178

Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
           APEV A +      Y+   D+W+LGITAIE+ E  PPL  +HPMRAL L+ ++   PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236

Query: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
           + K +W++ F  F+   L K    RP  E+LL+ PF   Q   R +  QL D        
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295

Query: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
               E+ E E Y    +   S G+ G
Sbjct: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  242 bits (618), Expect = 1e-63
 Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)

Query: 19  RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70

Query: 79  HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122

Query: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
           +GLA+LH+ K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182

Query: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
           V A        Y+   DIWSLGITAIE+AE  PPL D+HP+R LFL+ ++   PPRLK K
Sbjct: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240

Query: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
            KWS  F +FI   L K+   RP   ++L    +      R + + L D +    K    
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300

Query: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
              E EE E   +       +H      SS + +P     RR  EF +L   +    +N+
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355

Query: 367 EALKQQQQLQQQQQR 381
             L+  + L+    R
Sbjct: 356 ARLQPPRDLRSSSPR 370



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 994  NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1053
            +LL+G E G+ +L+R+ Q     ++   R   +  +   N+L+++SGK   L  + +  L
Sbjct: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570

Query: 1054 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1100
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630

Query: 1101 VEVYAWAPKPYHKFM 1115
            V +  W  +P +KF+
Sbjct: 631  VVLLQWY-QPMNKFL 644


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,710,411
Number of Sequences: 37866
Number of extensions: 3480275
Number of successful extensions: 79213
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1660
Number of HSP's successfully gapped in prelim test: 2366
Number of HSP's that attempted gapping in prelim test: 20086
Number of HSP's gapped (non-prelim): 23658
length of query: 1295
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1181
effective length of database: 13,930,794
effective search space: 16452267714
effective search space used: 16452267714
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.