Search of human proteins with 75709200

Search of human proteins with 75709200

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|75709200 glutathione peroxidase 4 isoform A precursor [Homo
sapiens]
         (197 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|75709200 glutathione peroxidase 4 isoform A precursor [Homo s...   416   e-117
gi|90903240 glutathione peroxidase 4 isoform C precursor [Homo s...   362   e-100
gi|90903238 glutathione peroxidase 4 isoform B precursor [Homo s...   355   2e-98
gi|15618997 glutathione peroxidase 7 [Homo sapiens]                   116   1e-26
gi|192455698 glutathione peroxidase 8 [Homo sapiens]                  108   2e-24
gi|41406084 glutathione peroxidase 1 isoform 1 [Homo sapiens]         101   5e-22
gi|32967607 glutathione peroxidase 2 [Homo sapiens]                    92   3e-19
gi|6006001 glutathione peroxidase 3 precursor [Homo sapiens]           84   6e-17
gi|4557629 glutathione peroxidase 5 isoform 1 precursor [Homo sa...    75   5e-14
gi|33186887 glutathione peroxidase 6 [Homo sapiens]                    75   5e-14
gi|41406082 glutathione peroxidase 1 isoform 2 [Homo sapiens]          62   3e-10
gi|16945972 kelch domain containing 3 [Homo sapiens]                   28   5.0  
gi|13376840 WD repeat domain 61 [Homo sapiens]                         27   8.6  

>gi|75709200 glutathione peroxidase 4 isoform A precursor [Homo
           sapiens]
          Length = 197

 Score =  416 bits (1070), Expect = e-117
 Identities = 197/197 (100%), Positives = 197/197 (100%)

Query: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60
           MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
Sbjct: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60

Query: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120
           GFVCIVTNVASQ GKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
Sbjct: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120

Query: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY 180
           AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY
Sbjct: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY 180

Query: 181 GPMEEPLVIEKDLPHYF 197
           GPMEEPLVIEKDLPHYF
Sbjct: 181 GPMEEPLVIEKDLPHYF 197


>gi|90903240 glutathione peroxidase 4 isoform C precursor [Homo
           sapiens]
          Length = 234

 Score =  362 bits (928), Expect = e-100
 Identities = 169/169 (100%), Positives = 169/169 (100%)

Query: 29  CASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHA 88
           CASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQ GKTEVNYTQLVDLHA
Sbjct: 66  CASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHA 125

Query: 89  RYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMK 148
           RYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMK
Sbjct: 126 RYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMK 185

Query: 149 IQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF 197
           IQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
Sbjct: 186 IQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF 234


>gi|90903238 glutathione peroxidase 4 isoform B precursor [Homo
           sapiens]
          Length = 227

 Score =  355 bits (910), Expect = 2e-98
 Identities = 168/168 (100%), Positives = 168/168 (100%)

Query: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60
           MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
Sbjct: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60

Query: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120
           GFVCIVTNVASQ GKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
Sbjct: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120

Query: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKF 168
           AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKF
Sbjct: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKF 168


>gi|15618997 glutathione peroxidase 7 [Homo sapiens]
          Length = 187

 Score =  116 bits (290), Expect = 1e-26
 Identities = 65/145 (44%), Positives = 88/145 (60%), Gaps = 7/145 (4%)

Query: 39  RSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRIL 98
           +  ++F A +I G +V+L+KYRG V +V NVAS+ G T+ +Y  L  L          +L
Sbjct: 23  QDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVL 82

Query: 99  AFPCNQFGKQEPGSNEEIKEFA-AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGIL 157
           AFPCNQFG+QEP SN+EI+ FA   Y+V F MFSKI V G  AHP +K++  Q  GK   
Sbjct: 83  AFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYL-AQTSGK--- 138

Query: 158 GNAIKWNFTKFLIDKNGCVVKRYGP 182
                WNF K+L+  +G VV  + P
Sbjct: 139 --EPTWNFWKYLVAPDGKVVGAWDP 161


>gi|192455698 glutathione peroxidase 8 [Homo sapiens]
          Length = 209

 Score =  108 bits (271), Expect = 2e-24
 Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 7/155 (4%)

Query: 40  SMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILA 99
           S + F  KD  G  V+L+KY+G V +V NVAS    T+ NY  L +LH  +      +LA
Sbjct: 46  SFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLA 105

Query: 100 FPCNQFGKQEPGSNEEIKEFA-AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILG 158
           FPCNQFG+ EP  ++E++ FA   Y V F +F KI + G +  P ++++    K +    
Sbjct: 106 FPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEP--- 162

Query: 159 NAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDL 193
              +WNF K+L++  G VVK + P E   VI  D+
Sbjct: 163 ---RWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDI 194


>gi|41406084 glutathione peroxidase 1 isoform 1 [Homo sapiens]
          Length = 203

 Score =  101 bits (251), Expect = 5e-22
 Identities = 69/192 (35%), Positives = 97/192 (50%), Gaps = 26/192 (13%)

Query: 28  MCASR--DDWRCARSMHEFSAKDI-DGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLV 84
           MCA+R       A+S++ FSA+ +  G  V+L   RG V ++ NVAS  G T  +YTQ+ 
Sbjct: 1   MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMN 60

Query: 85  DLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEF------AAGYNVKFDMFSKICVNGD 138
           +L  R    GL +L FPCNQFG QE   NEEI           G+   F +F K  VNG 
Sbjct: 61  ELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGA 120

Query: 139 DAHPLWKWMK--------------IQPK---GKGILGNAIKWNFTKFLIDKNGCVVKRYG 181
            AHPL+ +++                PK      +  N + WNF KFL+  +G  ++RY 
Sbjct: 121 GAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYS 180

Query: 182 PMEEPLVIEKDL 193
              + + IE D+
Sbjct: 181 RRFQTIDIEPDI 192


>gi|32967607 glutathione peroxidase 2 [Homo sapiens]
          Length = 190

 Score = 92.0 bits (227), Expect = 3e-19
 Identities = 61/179 (34%), Positives = 89/179 (49%), Gaps = 24/179 (13%)

Query: 38  ARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRI 97
           A+S ++ SA  +DG  V+ + +RG   ++ NVAS  G T  ++TQL +L  R+    L +
Sbjct: 5   AKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPR-RLVV 63

Query: 98  LAFPCNQFGKQEPGSNEEIKEF------AAGYNVKFDMFSKICVNGDDAHPLWKWMK--- 148
           L FPCNQFG QE   NEEI           GY   F +  K  VNG + HP++ ++K   
Sbjct: 64  LGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKL 123

Query: 149 ---------IQPKGKGILGNAIK-----WNFTKFLIDKNGCVVKRYGPMEEPLVIEKDL 193
                    +    K I+ + ++     WNF KFLI   G   +RY      + IE D+
Sbjct: 124 PYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDI 182


>gi|6006001 glutathione peroxidase 3 precursor [Homo sapiens]
          Length = 226

 Score = 84.3 bits (207), Expect = 6e-17
 Identities = 64/199 (32%), Positives = 93/199 (46%), Gaps = 25/199 (12%)

Query: 6   LCRLLKPALLCGALAAPGLAGTMCASRDDWRC----ARSMHEFSAKDIDGH-MVNLDKYR 60
           + RLL+ + L   L A  ++ +    +    C    + +++E+ A  IDG   +   +Y 
Sbjct: 1   MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYA 60

Query: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEF- 119
           G   +  NVAS  G T   Y +L  L    A  GL IL FPCNQFGKQEPG N EI    
Sbjct: 61  GKYVLFVNVASYUGLTG-QYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTL 119

Query: 120 -----AAGYNVKFDMFSKICVNGDDAHPLWKWMKIQ-PKGKGILGNA------------I 161
                  G+   F +F K  VNG+     + ++K   P    +LG +            I
Sbjct: 120 KYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDI 179

Query: 162 KWNFTKFLIDKNGCVVKRY 180
           +WNF KFL+  +G  + R+
Sbjct: 180 RWNFEKFLVGPDGIPIMRW 198


>gi|4557629 glutathione peroxidase 5 isoform 1 precursor [Homo
           sapiens]
          Length = 221

 Score = 74.7 bits (182), Expect = 5e-14
 Identities = 53/162 (32%), Positives = 75/162 (46%), Gaps = 20/162 (12%)

Query: 54  VNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSN 113
           V+  +Y G   +  NVA+  G T   Y +L  L       GL +L FPCNQFGKQEPG N
Sbjct: 54  VSFKQYVGKHILFVNVATYCGLT-AQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDN 112

Query: 114 EEI------KEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQ-PKGKGILG-------- 158
           +EI           G+   F +F K  VNG+    ++ ++K   P    ILG        
Sbjct: 113 KEILPGLKYVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWD 172

Query: 159 ----NAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHY 196
               + I+WNF KFL+  +G  V R+        ++ D+  Y
Sbjct: 173 PVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAY 214


>gi|33186887 glutathione peroxidase 6 [Homo sapiens]
          Length = 221

 Score = 74.7 bits (182), Expect = 5e-14
 Identities = 52/177 (29%), Positives = 85/177 (48%), Gaps = 21/177 (11%)

Query: 40  SMHEFSAKDIDGH-MVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRIL 98
           +++E+ A  ++G   +   ++ G   +  NVA+  G     Y +L  L       G+ +L
Sbjct: 39  TIYEYGALTLNGEEYIQFKQFAGKHVLFVNVAAYUGLA-AQYPELNALQEELKNFGVIVL 97

Query: 99  AFPCNQFGKQEPGSNEEIKEF------AAGYNVKFDMFSKICVNGDDAHPLWKWMKIQ-P 151
           AFPCNQFGKQEPG+N EI          +G+   F +F K  VNG+    ++ ++K   P
Sbjct: 98  AFPCNQFGKQEPGTNSEILLGLKYVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCP 157

Query: 152 KGKGILGNA------------IKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHY 196
               +LG++            I+WNF KFL+  +G  V  +        ++ D+  Y
Sbjct: 158 PTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEY 214


>gi|41406082 glutathione peroxidase 1 isoform 2 [Homo sapiens]
          Length = 98

 Score = 62.0 bits (149), Expect = 3e-10
 Identities = 38/84 (45%), Positives = 51/84 (60%), Gaps = 3/84 (3%)

Query: 28  MCASR--DDWRCARSMHEFSAKDI-DGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLV 84
           MCA+R       A+S++ FSA+ +  G  V+L   RG V ++ NVAS  G T  +YTQ+ 
Sbjct: 1   MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMN 60

Query: 85  DLHARYAECGLRILAFPCNQFGKQ 108
           +L  R    GL +L FPCNQFG Q
Sbjct: 61  ELQRRLGPRGLVVLGFPCNQFGHQ 84


>gi|16945972 kelch domain containing 3 [Homo sapiens]
          Length = 382

 Score = 28.1 bits (61), Expect = 5.0
 Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 17/52 (32%)

Query: 111 GSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWK-------WMKIQPKGKG 155
           G N E+  F  GYN + +            H LWK       W KI+PKGKG
Sbjct: 246 GYNGELYIFG-GYNARLNRHF---------HDLWKFNPVSFTWKKIEPKGKG 287


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 27.3 bits (59), Expect = 8.6
 Identities = 16/47 (34%), Positives = 24/47 (51%), Gaps = 3/47 (6%)

Query: 103 NQFG---KQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKW 146
           NQ+G   KQE   ++ I   A G N K +  + +  + DD   +WKW
Sbjct: 3   NQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW 49


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,054,180
Number of Sequences: 37866
Number of extensions: 330661
Number of successful extensions: 544
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 520
Number of HSP's gapped (non-prelim): 13
length of query: 197
length of database: 18,247,518
effective HSP length: 97
effective length of query: 100
effective length of database: 14,574,516
effective search space: 1457451600
effective search space used: 1457451600
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.