Guide to the Human Genome
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Search of human proteins with 73466520

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
         (508 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]      1014   0.0  
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]        962   0.0  
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]                 639   0.0  
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]                639   0.0  
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]                639   0.0  
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]      508   e-144
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]        508   e-144
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]       470   e-132
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]                 410   e-114
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]                 410   e-114
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]                150   3e-36
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]                148   1e-35
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]       142   9e-34
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa...   139   6e-33
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]                 139   8e-33
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]       133   4e-31
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]       133   4e-31
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ...   131   2e-30
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]       127   3e-29
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo...   125   1e-28
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap...   123   5e-28
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho...   122   6e-28
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]       118   1e-26
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]       117   2e-26
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]        94   4e-19
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa...    91   2e-18
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    64   4e-10
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]       64   4e-10
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    64   4e-10
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform...    38   0.019

>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
          Length = 508

 Score = 1014 bits (2622), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
           MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
Sbjct: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60

Query: 61  VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120
           VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
Sbjct: 61  VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120

Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180
           PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
Sbjct: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180

Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240
           IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
Sbjct: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240

Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300
           CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
Sbjct: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300

Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360
           AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
Sbjct: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360

Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420
           LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
Sbjct: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420

Query: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480
           HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
Sbjct: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480

Query: 481 KKYQAVLRRKALLIFLVVHRLRWSSKQR 508
           KKYQAVLRRKALLIFLVVHRLRWSSKQR
Sbjct: 481 KKYQAVLRRKALLIFLVVHRLRWSSKQR 508


>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  962 bits (2488), Expect = 0.0
 Identities = 481/481 (100%), Positives = 481/481 (100%)

Query: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
           MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
Sbjct: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60

Query: 61  VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120
           VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
Sbjct: 61  VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120

Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180
           PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
Sbjct: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180

Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240
           IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
Sbjct: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240

Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300
           CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
Sbjct: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300

Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360
           AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
Sbjct: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360

Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420
           LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
Sbjct: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420

Query: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480
           HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
Sbjct: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV 480

Query: 481 K 481
           K
Sbjct: 481 K 481


>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  639 bits (1648), Expect = 0.0
 Identities = 297/439 (67%), Positives = 377/439 (85%)

Query: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
           V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 8   VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67

Query: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
           L EI++M++ LPEW   +PV+K   T  DE YI  +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 68  LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127

Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
           AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187

Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
           G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247

Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
           DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307

Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
             D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367

Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
           S N K+IK+MI ETSSGGV  NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R 
Sbjct: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427

Query: 425 CLLKSLKREGANKLRYPPN 443
           CL++ L  +   K+RYPP+
Sbjct: 428 CLVRPLMNDEGLKVRYPPS 446


>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  639 bits (1648), Expect = 0.0
 Identities = 297/439 (67%), Positives = 377/439 (85%)

Query: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
           V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 8   VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67

Query: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
           L EI++M++ LPEW   +PV+K   T  DE YI  +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 68  LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127

Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
           AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187

Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
           G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247

Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
           DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307

Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
             D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367

Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
           S N K+IK+MI ETSSGGV  NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R 
Sbjct: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427

Query: 425 CLLKSLKREGANKLRYPPN 443
           CL++ L  +   K+RYPP+
Sbjct: 428 CLVRPLMNDEGLKVRYPPS 446


>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  639 bits (1648), Expect = 0.0
 Identities = 297/439 (67%), Positives = 377/439 (85%)

Query: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
           V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 8   VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67

Query: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
           L EI++M++ LPEW   +PV+K   T  DE YI  +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 68  LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127

Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
           AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187

Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
           G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247

Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
           DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307

Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
             D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367

Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
           S N K+IK+MI ETSSGGV  NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R 
Sbjct: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427

Query: 425 CLLKSLKREGANKLRYPPN 443
           CL++ L  +   K+RYPP+
Sbjct: 428 CLVRPLMNDEGLKVRYPPS 446


>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  508 bits (1308), Expect = e-144
 Identities = 245/444 (55%), Positives = 324/444 (72%)

Query: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
           +RR+R+AF +GR+RP  FR  QL+ L R +QE ++ +  A+A DL KS F     EV   
Sbjct: 8   LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67

Query: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
            GE+   L NL  W+  + V KN+ T LD A+I+ +P G+VLII  WNYP  LT+ PL+G
Sbjct: 68  QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127

Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
           A+AAGN V++KPSE+S+N  KILA++LPQY+DQ  + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187

Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
           G+  VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD   V  R+ W +Y N GQTC+AP
Sbjct: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247

Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
           DY+LC   +Q +++  ++ T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG
Sbjct: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307

Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
           ++DE+ RYIAPTVL DV     VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367

Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
           S++ +++KR++ +TSSGG  GND  MH TL S PFGGVG+SGMG YHGK SFDTFSH R 
Sbjct: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427

Query: 425 CLLKSLKREGANKLRYPPNSQSKV 448
           CLL+S   E  N LRYPP S  ++
Sbjct: 428 CLLRSPGMEKLNALRYPPQSPRRL 451


>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  508 bits (1308), Expect = e-144
 Identities = 245/444 (55%), Positives = 324/444 (72%)

Query: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
           +RR+R+AF +GR+RP  FR  QL+ L R +QE ++ +  A+A DL KS F     EV   
Sbjct: 8   LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAIS 67

Query: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
            GE+   L NL  W+  + V KN+ T LD A+I+ +P G+VLII  WNYP  LT+ PL+G
Sbjct: 68  QGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 127

Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
           A+AAGN V++KPSE+S+N  KILA++LPQY+DQ  + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 128 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 187

Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
           G+  VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD   V  R+ W +Y N GQTC+AP
Sbjct: 188 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 247

Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
           DY+LC   +Q +++  ++ T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG
Sbjct: 248 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 307

Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
           ++DE+ RYIAPTVL DV     VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 308 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 367

Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
           S++ +++KR++ +TSSGG  GND  MH TL S PFGGVG+SGMG YHGK SFDTFSH R 
Sbjct: 368 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 427

Query: 425 CLLKSLKREGANKLRYPPNSQSKV 448
           CLL+S   E  N LRYPP S  ++
Sbjct: 428 CLLRSPGMEKLNALRYPPQSPRRL 451


>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
          Length = 431

 Score =  470 bits (1210), Expect = e-132
 Identities = 232/444 (52%), Positives = 308/444 (69%), Gaps = 37/444 (8%)

Query: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
           +RR+R+AF +GR+RP  FR  QL+ L R +QE ++ +  A+A DL K+            
Sbjct: 8   LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKA------------ 55

Query: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
                                    T LD A+I+ +P G+VLII  WNYP  LT+ PL+G
Sbjct: 56  -------------------------TQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 90

Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
           A+AAGN V++KPSE+S+N  KILA++LPQY+DQ  + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 91  ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 150

Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
           G+  VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD   V  R+ W +Y N GQTC+AP
Sbjct: 151 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 210

Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
           DY+LC   +Q +++  ++ T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG
Sbjct: 211 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 270

Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
           ++DE+ RYIAPTVL DV     VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 271 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 330

Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
           S++ +++KR++ +TSSGG  GND  MH TL S PFGGVG+SGMG YHGK SFDTFSH R 
Sbjct: 331 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 390

Query: 425 CLLKSLKREGANKLRYPPNSQSKV 448
           CLL+S   E  N LRYPP S  ++
Sbjct: 391 CLLRSPGMEKLNALRYPPQSPRRL 414


>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  410 bits (1054), Expect = e-114
 Identities = 195/373 (52%), Positives = 266/373 (71%), Gaps = 3/373 (0%)

Query: 82  KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141
           +P   N+   LD  +I  +P G+VLII  WNYP  LT+  L+GA+AAG+ V++KPSE+S+
Sbjct: 4   EPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQ 63

Query: 142 NTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHL 201
            T K+LA++LPQYLDQ  + V+ GG +ET +LL+ + D+IF+TG+  VGKIVM AA KHL
Sbjct: 64  GTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHL 123

Query: 202 TPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKI 261
           TPVTLELGGK+PCY+D +CD   V  R+ W  Y N GQTC+APDY+LC   +Q +++  +
Sbjct: 124 TPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPAL 183

Query: 262 KETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDV 321
           + T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG+++E+ RYIAPTVL DV
Sbjct: 184 QSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDV 243

Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
                VMQEEIFGPILPIV V++VDEAI FIN +EKPLALY FS++ +++ +M++ TSSG
Sbjct: 244 QETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSG 303

Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYP 441
              GN+   + +L S PFGGVG SGMG YHGK +FDTFSH R CLL     E   ++ YP
Sbjct: 304 SFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHYP 363

Query: 442 PN---SQSKVDWG 451
           P    +Q  + WG
Sbjct: 364 PYTDWNQQLLRWG 376


>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  410 bits (1054), Expect = e-114
 Identities = 195/373 (52%), Positives = 266/373 (71%), Gaps = 3/373 (0%)

Query: 82  KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141
           +P   N+   LD  +I  +P G+VLII  WNYP  LT+  L+GA+AAG+ V++KPSE+S+
Sbjct: 4   EPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQ 63

Query: 142 NTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHL 201
            T K+LA++LPQYLDQ  + V+ GG +ET +LL+ + D+IF+TG+  VGKIVM AA KHL
Sbjct: 64  GTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHL 123

Query: 202 TPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKI 261
           TPVTLELGGK+PCY+D +CD   V  R+ W  Y N GQTC+APDY+LC   +Q +++  +
Sbjct: 124 TPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPAL 183

Query: 262 KETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDV 321
           + T+  FYG++ + SP+  RIIN + F+R+ +LL   ++A GG+++E+ RYIAPTVL DV
Sbjct: 184 QSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDV 243

Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
                VMQEEIFGPILPIV V++VDEAI FIN +EKPLALY FS++ +++ +M++ TSSG
Sbjct: 244 QETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSG 303

Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYP 441
              GN+   + +L S PFGGVG SGMG YHGK +FDTFSH R CLL     E   ++ YP
Sbjct: 304 SFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHYP 363

Query: 442 PN---SQSKVDWG 451
           P    +Q  + WG
Sbjct: 364 PYTDWNQQLLRWG 376


>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
          Length = 518

 Score =  150 bits (378), Expect = 3e-36
 Identities = 122/439 (27%), Positives = 209/439 (47%), Gaps = 30/439 (6%)

Query: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
           + L V+  + AF     +    R + L    R+++ERE +I T    +  KS F      
Sbjct: 75  VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-- 132

Query: 61  VITVLGEIDFMLENLPEW--VTAKPVKKNV-LTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117
                 +ID   + L  +  + A    +++ L      Y + +PLGV + IGAWNYPF +
Sbjct: 133 ------DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 186

Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 176
                  A+A GNA++ KPS  +  +A +LA++  +  +   L+ V+ GG   T + L Q
Sbjct: 187 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFLCQ 245

Query: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
             D   + +TG+   G  +ME +AK + PVTLELGGKSP  I  DCD++   +      +
Sbjct: 246 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 305

Query: 235 MNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGENIKESPDYERIINLRHFKRILS 293
           +  GQ C     +  +  + ++   + +K+T +   G+ + E      +IN  H +R+L 
Sbjct: 306 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 365

Query: 294 LL-----EGQKIAFGGE----TDEATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341
            +     +G K+  GG+     D   +   Y+ P VLT+       ++EEIFGP++ I+ 
Sbjct: 366 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 425

Query: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 401
                E +   N+    LA  VF+ + +   R++ E  +G    N+   + +    PFGG
Sbjct: 426 FDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGG 483

Query: 402 VGSSGMGAYHGKHSFDTFS 420
              SG G  +G+ + + +S
Sbjct: 484 YKKSGFGRENGRVTIEYYS 502


>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
          Length = 512

 Score =  148 bits (374), Expect = 1e-35
 Identities = 102/344 (29%), Positives = 169/344 (49%), Gaps = 13/344 (3%)

Query: 96  YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
           + + +P+GV   I  WN+P ++ +  L  A+  GN +++KP+E +  TA  L  L+ +  
Sbjct: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224

Query: 156 DQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
                + I  G   T         + + I +TG+T VGK+V EAA++ +L  VTLELGGK
Sbjct: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284

Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
           +PC +  D DLD+       G + N GQ C A   +  E  + ++ V +  E  K+   G
Sbjct: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344

Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
           +      +    I+ + F +IL L+     EG K+  GG   ++   +I PTV ++V   
Sbjct: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404

Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
            ++ +EEIFGP+ PI+  K+++E I   N  +  L   VF+ N     ++     SG V 
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464

Query: 385 GNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
            N    +      PFGG   SG G   G+++   ++  +   +K
Sbjct: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506


>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
          Length = 487

 Score =  142 bits (357), Expect = 9e-34
 Identities = 123/450 (27%), Positives = 210/450 (46%), Gaps = 32/450 (7%)

Query: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
           +E  V+  R+AF S  SR  + R + L  +  ++++  ++   A + D  K+        
Sbjct: 47  IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99

Query: 61  VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
            +    +I   ++N   + ++     +  T +D      Y    P+GV  +I  WN P  
Sbjct: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159

Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
           L    +  A+AAGN VI KPSEL+  TA +L KLL +  +   +  ++ G      E L 
Sbjct: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219

Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
                  I +TG+    + + + +A H   ++LELGGK+P  I +D +LD          
Sbjct: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSS 279

Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESP--DYERIINLRHFKRI 291
           + N G+ C+    I  + S+ ++ + +  E  ++ +   I   P      +I+  H +++
Sbjct: 280 FANQGEICLCTSRIFVQKSIYSEFLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKV 338

Query: 292 LS-----LLEGQKIAFGGETD--------EATRYIAPTVLTDVDPKTKVMQEEIFGPILP 338
            S     L EG +I  G   D        +A  ++ PTV+TD+  ++  M EEIFGP+  
Sbjct: 339 RSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTC 398

Query: 339 IVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFP 398
           +VP  + +E I   N  +  LA  V+S N   + R+  +  SG V  N  ++   LN  P
Sbjct: 399 VVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LP 456

Query: 399 FGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
           FGG+ SSG+G    K S+D F+  +   +K
Sbjct: 457 FGGMKSSGIGREGAKDSYDFFTEIKTITVK 486


>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
           sapiens]
          Length = 923

 Score =  139 bits (350), Expect = 6e-33
 Identities = 100/337 (29%), Positives = 172/337 (51%), Gaps = 15/337 (4%)

Query: 96  YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQY 154
           + + +PLGV  II  WNYP ++        +AAGN +++KP++++  TA   A+L +   
Sbjct: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638

Query: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
             + +  +I G      + L +  D   + +TG+T +GK +M++ A  +L  V+LELGGK
Sbjct: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698

Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
           SP  I  DC+LD   R      + N G+ CIA   +  E S+ ++ V ++ E +K+   G
Sbjct: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758

Query: 271 ENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPK 324
           + +  S D+    +  H +++L      + EG  + +GG +      ++ PTV TDV+  
Sbjct: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818

Query: 325 TKVMQEEIFGPILPIVPVKN--VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382
             + +EE FGPI+ I   +N  +D  +   N  E  LA  VF+ +      + ++  +G 
Sbjct: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878

Query: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
           V  N    + T  + PFGGV  SG G   G+ + + +
Sbjct: 879 VFIN--TYNKTDVAAPFGGVKQSGFGKDLGEEALNEY 913


>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
          Length = 501

 Score =  139 bits (349), Expect = 8e-33
 Identities = 107/357 (29%), Positives = 169/357 (47%), Gaps = 18/357 (5%)

Query: 83  PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142
           P+  N  T     Y + +P+GV   I  WN+P V+ I  +  A++ GN V++KP+E +  
Sbjct: 146 PIDGNFFT-----YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200

Query: 143 TAKILAKLLPQYLDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK 199
           TA  +A L+ +       + I  G   T           D + +TG+T VGK++ EAA K
Sbjct: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260

Query: 200 -HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258
            +L  VTLELGGKSPC +  D DLD        G + + GQ CIA   I  E S+ ++ V
Sbjct: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320

Query: 259 WKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKI-AFGGETDEATR 311
            +  E  K++  G  +         I+   + +IL L+     EG K+   GG       
Sbjct: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380

Query: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371
           ++ PTV ++V  + ++ +EEIFGP+  I+  K++D+ I   N     L+  VF+ +    
Sbjct: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440

Query: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
             +     +G V  N           PFGG   SG G   G++ F  ++  +   +K
Sbjct: 441 ITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495


>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
          Length = 422

 Score =  133 bits (334), Expect = 4e-31
 Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)

Query: 96  YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
           + + +P+GV   I  WN+P ++    +  A+  GN V+IKP+E +  +A  +  L+ +  
Sbjct: 75  FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134

Query: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
                I I  G   T           D I +TG+T VGK++ EAA + +L  VTLELGGK
Sbjct: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194

Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
           SP  I  D DLD    +   G + N GQ C A   I  E S+  + V +  E  K    G
Sbjct: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254

Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
                + +    I+ + + +IL L+     EG K+  GG+       +I PTV ++V   
Sbjct: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314

Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
            ++ +EEIFGP+  I+  K +DE I   N  +  L   VF+++      +     +G V 
Sbjct: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374

Query: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
            N    +  LN+  PFGG   SG G   G+     +S  +   +K
Sbjct: 375 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416


>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
          Length = 518

 Score =  133 bits (334), Expect = 4e-31
 Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)

Query: 96  YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
           + + +P+GV   I  WN+P ++    +  A+  GN V+IKP+E +  +A  +  L+ +  
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230

Query: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
                I I  G   T           D I +TG+T VGK++ EAA + +L  VTLELGGK
Sbjct: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290

Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
           SP  I  D DLD    +   G + N GQ C A   I  E S+  + V +  E  K    G
Sbjct: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350

Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
                + +    I+ + + +IL L+     EG K+  GG+       +I PTV ++V   
Sbjct: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410

Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
            ++ +EEIFGP+  I+  K +DE I   N  +  L   VF+++      +     +G V 
Sbjct: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470

Query: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
            N    +  LN+  PFGG   SG G   G+     +S  +   +K
Sbjct: 471 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512


>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
           sapiens]
          Length = 535

 Score =  131 bits (329), Expect = 2e-30
 Identities = 92/339 (27%), Positives = 160/339 (47%), Gaps = 16/339 (4%)

Query: 95  AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
           A +  QP+GV  +I  WN+P  +  + +  A+AAG  V++KP+E +  +A  LA+L  Q 
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247

Query: 155 -LDQDLYIVINGGVEETTEL-----LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 208
            +   +Y VI    +   E+            I +TG+T  GKI++  AA  +  V++EL
Sbjct: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307

Query: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE- 267
           GG +P  +    ++D         K+ N GQTC+  +  L +  + +  V    E +K+ 
Sbjct: 308 GGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKN 367

Query: 268 -FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE-ATRYIAPTVLTD 320
              G   +E      +IN +  +++      ++ +G  +  GG+  +    +  PT+L +
Sbjct: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 427

Query: 321 VDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 380
           V        EE FGP+ P++     +EAI   N  +  LA Y +S +   I R+ ++   
Sbjct: 428 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 487

Query: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
           G V  N+ ++       PFGGV  SG+G    K+  D +
Sbjct: 488 GMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 524


>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
          Length = 517

 Score =  127 bits (318), Expect = 3e-29
 Identities = 99/347 (28%), Positives = 157/347 (45%), Gaps = 19/347 (5%)

Query: 96  YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY- 154
           + + +P+GV   I  WN+P V+    L  A+A GN V++K +E +  +A  LA L+ +  
Sbjct: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229

Query: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
               +  +I G        + Q  D   + +TG+T VG ++ +AA   +L  VTLELGGK
Sbjct: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289

Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYG 270
           SP  +  D D++    +     + N GQ C A      E S+ N+ + +  E  K+   G
Sbjct: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349

Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
              +        ++   F+R+L  +     EG K+  GGE   E   +I PTV   V   
Sbjct: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409

Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV- 383
            ++ +EEIFGP+ P+   K ++E +   N     LA  VF+ +            +G V 
Sbjct: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469

Query: 384 --TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
             T N V  H      PFGG   SG G   G+     ++  +   +K
Sbjct: 470 VNTYNIVTCH-----TPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511


>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
           sapiens]
          Length = 548

 Score =  125 bits (313), Expect = 1e-28
 Identities = 92/352 (26%), Positives = 162/352 (46%), Gaps = 29/352 (8%)

Query: 95  AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
           A +  QP+GV  +I  WN+P  +  + +  A+AAG  V++KP+E +  +A  LA++   +
Sbjct: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247

Query: 155 L-DQDLYIV-----INGGVEETTELLKQR-------------FDHIFYTGNTAVGKIVME 195
           L D D  ++     I  GV       ++                 I +TG+T  GKI++ 
Sbjct: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307

Query: 196 AAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255
            AA  +  V++ELGG +P  +    ++D         K+ N GQTC+  +  L +  + +
Sbjct: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 367

Query: 256 QIVWKIKETVKE--FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE 308
             V    E +K+    G   +E      +IN +  +++      ++ +G  +  GG+  +
Sbjct: 368 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 427

Query: 309 -ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHN 367
               +  PT+L +V        EE FGP+ P++     +EAI   N  +  LA Y +S +
Sbjct: 428 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 487

Query: 368 HKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
              I R+ ++   G V  N+ ++       PFGGV  SG+G    K+  D +
Sbjct: 488 PAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 537


>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
           sapiens]
          Length = 902

 Score =  123 bits (308), Expect = 5e-28
 Identities = 98/333 (29%), Positives = 164/333 (49%), Gaps = 15/333 (4%)

Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQD 158
           +P+GV  II  WNYP ++        +AAGN V+IKP++++  TA   A+L L   + + 
Sbjct: 562 EPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKG 621

Query: 159 LYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGKSPCY 215
           +  V+ G      + L    D   I +TG+T VGK +M++ A  ++  V+LELGGKSP  
Sbjct: 622 VVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLI 681

Query: 216 IDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIK 274
           I  DCDL+   +      + N G+ CIA   +  E S+ ++ V ++ E V++   G  + 
Sbjct: 682 IFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLD 741

Query: 275 ESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVM 328
              D+    +  H  +++      + EG  +  GG +      +  PTV TDV+    + 
Sbjct: 742 RDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIA 801

Query: 329 QEEIFGPILPIVPVK--NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386
           +EE FGP++ I      ++D  ++  N  E  LA  VF+ +      + D+  +G V  N
Sbjct: 802 KEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN 861

Query: 387 DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
               + T  + PFGG   SG G   G+ + + +
Sbjct: 862 --TYNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892


>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
           sapiens]
          Length = 517

 Score =  122 bits (307), Expect = 6e-28
 Identities = 98/347 (28%), Positives = 158/347 (45%), Gaps = 17/347 (4%)

Query: 95  AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
           +Y + +P+GV   I  WN+P ++    L  A+A GN V++K +E +  TA  +A L+ + 
Sbjct: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228

Query: 155 LDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAA-AKHLTPVTLELGG 210
                 + I  G   T        +  D + +TG+T +G+++  AA + +L  VTLELGG
Sbjct: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288

Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFY 269
           KSP  I  D D+D    +  +  + N GQ C A      +  + ++ V + +        
Sbjct: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348

Query: 270 GENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATRY-IAPTVLTDVDP 323
           G       +    ++   FK+IL  +     EG K+  GG       Y I PTV  DV  
Sbjct: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408

Query: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV 383
              + +EEIFGP++ I+  K ++E +   N     LA  VF+ +      +     +G V
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468

Query: 384 TGN--DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
             N  DV   F   S PFGG   SG G   G++    ++  +   +K
Sbjct: 469 WVNCYDV---FGAQS-PFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511


>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
          Length = 433

 Score =  118 bits (296), Expect = 1e-26
 Identities = 118/439 (26%), Positives = 195/439 (44%), Gaps = 64/439 (14%)

Query: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
           +E  V+  R+AF S  SR  + R + L  +  ++++  ++   A + D  K+        
Sbjct: 47  IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99

Query: 61  VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
            +    +I   ++N   + ++     +  T +D      Y    P+GV  +I  WN P  
Sbjct: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159

Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
           L    +  A+AAGN VI KPSEL+  TA +L KLL +  +   +  ++ G      E L 
Sbjct: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219

Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
                  I +TG+    + + + +A H   ++LELGGK+P  I +D +LD          
Sbjct: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLD---------- 269

Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE----FYGENIKESPDYERIINLRHFK 289
                  CI        +S  NQ+   +K  + E    + GE + +              
Sbjct: 270 ------ECIP---ATVRSSFANQVRSYVKRALAEGAQIWCGEGVDK-------------- 306

Query: 290 RILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAI 349
             LSL            ++A  ++ PTV+TD+  ++  M EEIFGP+  +VP  + +E I
Sbjct: 307 --LSL---------PARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVI 355

Query: 350 NFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 409
              N  +  LA  V+S N   + R+  +  SG V  N  ++   LN  PFGG+ SSG+G 
Sbjct: 356 ERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LPFGGMKSSGIGR 413

Query: 410 YHGKHSFDTFSHQRPCLLK 428
              K S+D F+  +   +K
Sbjct: 414 EGAKDSYDFFTEIKTITVK 432


>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
          Length = 480

 Score =  117 bits (294), Expect = 2e-26
 Identities = 96/342 (28%), Positives = 151/342 (44%), Gaps = 47/342 (13%)

Query: 96  YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
           + + +P+GV   I  WN+P ++    +  A+  GN V+IKP+E +  +A  +  L+ +  
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228

Query: 156 DQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPC 214
                                            VGK++ EAA + +L  VTLELGGKSP 
Sbjct: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255

Query: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYGENI 273
            I  D DLD    +   G + N GQ C A   I  E S+  + V +  E  K    G   
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315

Query: 274 KESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPKTKV 327
             + +    I+ + + +IL L+     EG K+  GG+       +I PTV ++V    ++
Sbjct: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375

Query: 328 MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387
            +EEIFGP+  I+  K +DE I   N  +  L   VF+++      +     +G V  N 
Sbjct: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434

Query: 388 VIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
              +  LN+  PFGG   SG G   G+     +S  +   +K
Sbjct: 435 --CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474


>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
          Length = 535

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 101/455 (22%), Positives = 185/455 (40%), Gaps = 32/455 (7%)

Query: 1   MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAAD----LCKSEFNV 56
           M+  +   ++AF +     +  R Q L   +++++E  K+I   I  +    L  +E +V
Sbjct: 79  MDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDV 138

Query: 57  YSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116
           +    +    E    + +L    T   + K++     + Y    PLGV   I  +N+P +
Sbjct: 139 FRGLQVV---EHACSVTSLMMGETMPSITKDM-----DLYSYRLPLGVCAGIAPFNFPAM 190

Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQ 176
           + +     A+  GN  ++KPSE       +LAKLL      D  + I  G  E    +  
Sbjct: 191 IPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICD 250

Query: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
             D   I + G+   G+ + E  ++H   V   +G K+   +  D + +    ++    +
Sbjct: 251 HPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAF 310

Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSL 294
              GQ C+A    +     +  +   ++           +   D   +I  +  +R+ +L
Sbjct: 311 GAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNL 370

Query: 295 ------------LEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV 342
                       L+G+KI   G   E   ++ PT++++V P     +EEIFGP+L ++  
Sbjct: 371 IDSGTKEGASILLDGRKIKVKGY--ENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLET 428

Query: 343 KNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGV 402
           + +DEAI  +N         +F+ N    ++       G V G +V +   L  F F G 
Sbjct: 429 ETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQV-GVNVPIPVPLPMFSFTGS 487

Query: 403 GSSGMG--AYHGKHSFDTFSHQRPCLLKSLKREGA 435
            SS  G   ++GK     F  Q   +    K E A
Sbjct: 488 RSSFRGDTNFYGKQGIQ-FYTQLKTITSQWKEEDA 521


>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
           sapiens]
          Length = 539

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 85/351 (24%), Positives = 150/351 (42%), Gaps = 20/351 (5%)

Query: 98  QPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIK----PSELSENTAKILAKLLPQ 153
           Q  P+G+V II A+N+P  +       A+  GN  + K     S +S    KI+AK+L  
Sbjct: 181 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 240

Query: 154 Y-LDQDLYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211
             L   +  +  GG +  T + K +R + + +TG+T VGK V     +      LELGG 
Sbjct: 241 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 300

Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271
           +     +D DL +V     +      GQ C     +    S+ +++V ++K+   +    
Sbjct: 301 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI--- 357

Query: 272 NIKESPDYERIINLRHFKRILSLL---------EGQKIAFGGET-DEATRYIAPTVLTDV 321
            +    D   +    H K+ +S+          EG  + +GG+  D    Y+ PT++T +
Sbjct: 358 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 417

Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
                +   E F PIL +   KN +E   + NE ++ L+  +F+ +   I R +    S 
Sbjct: 418 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477

Query: 382 -GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431
            G+   ++          FGG   +G G   G  ++  +  +  C +   K
Sbjct: 478 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSK 528


>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)

Query: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
           L GA A  GN V+ KPS+ +   +  + ++L     P  + Q  ++  +G +   T    
Sbjct: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276

Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
           +    I +TG+    K + +  A++L        +  E GGK+  ++ +  D++ V    
Sbjct: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336

Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
               +   GQ C A   +    SL  QI  ++ E       G+  ++    +  +I+ + 
Sbjct: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396

Query: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
           F RI   LE  +      I  GG+ D++  Y + P ++   DP+  +M+EEIFGP+L   
Sbjct: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456

Query: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
           + P     E +  ++      L   VFS +  +++    +   ++G    ND      + 
Sbjct: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516

Query: 396 SFPFGGVGSSG 406
             PFGG  +SG
Sbjct: 517 QQPFGGARASG 527


>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
          Length = 503

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)

Query: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
           L GA A  GN V+ KPS+ +   +  + ++L     P  + Q  ++  +G +   T    
Sbjct: 159 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 216

Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
           +    I +TG+    K + +  A++L        +  E GGK+  ++ +  D++ V    
Sbjct: 217 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 276

Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
               +   GQ C A   +    SL  QI  ++ E       G+  ++    +  +I+ + 
Sbjct: 277 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 336

Query: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
           F RI   LE  +      I  GG+ D++  Y + P ++   DP+  +M+EEIFGP+L   
Sbjct: 337 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 396

Query: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
           + P     E +  ++      L   VFS +  +++    +   ++G    ND      + 
Sbjct: 397 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 456

Query: 396 SFPFGGVGSSG 406
             PFGG  +SG
Sbjct: 457 QQPFGGARASG 467


>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)

Query: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
           L GA A  GN V+ KPS+ +   +  + ++L     P  + Q  ++  +G +   T    
Sbjct: 219 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 276

Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
           +    I +TG+    K + +  A++L        +  E GGK+  ++ +  D++ V    
Sbjct: 277 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 336

Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
               +   GQ C A   +    SL  QI  ++ E       G+  ++    +  +I+ + 
Sbjct: 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 396

Query: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
           F RI   LE  +      I  GG+ D++  Y + P ++   DP+  +M+EEIFGP+L   
Sbjct: 397 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 456

Query: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
           + P     E +  ++      L   VFS +  +++    +   ++G    ND      + 
Sbjct: 457 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 516

Query: 396 SFPFGGVGSSG 406
             PFGG  +SG
Sbjct: 517 QQPFGGARASG 527


>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
           [Homo sapiens]
          Length = 751

 Score = 38.1 bits (87), Expect = 0.019
 Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)

Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL 159
           +PLGV+ ++    +P +  +  L  A+A GN V++ PS      A  + + +       L
Sbjct: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGL 667

Query: 160 YIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209
             V+ G  +  T    L Q    ++Y G+    + V  A+A +L PV    G
Sbjct: 668 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,369,787
Number of Sequences: 37866
Number of extensions: 805551
Number of successful extensions: 1914
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1822
Number of HSP's gapped (non-prelim): 43
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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