Search of human proteins with 71361682

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
         (2115 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]       4009   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       289   2e-77
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       289   2e-77
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        289   2e-77
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        289   2e-77
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        289   2e-77
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        289   2e-77
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        289   2e-77
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        289   2e-77
gi|21735548 centrosomal protein 2 [Homo sapiens]                      282   2e-75
gi|148746195 trichohyalin [Homo sapiens]                              262   3e-69
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               255   3e-67
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    241   5e-63
gi|71061468 centromere protein E [Homo sapiens]                       228   6e-59
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   225   3e-58
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      220   1e-56
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   215   3e-55
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          210   1e-53
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          210   1e-53
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          210   1e-53
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            210   1e-53
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   208   4e-53
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   207   1e-52
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   207   1e-52
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   206   3e-52
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   206   3e-52
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   204   6e-52
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   204   7e-52
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    203   2e-51
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   201   8e-51

>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 4009 bits (10398), Expect = 0.0
 Identities = 2115/2115 (100%), Positives = 2115/2115 (100%)

Query: 1    MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER 60
            MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER
Sbjct: 1    MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER 60

Query: 61   LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE 120
            LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE
Sbjct: 61   LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFE 120

Query: 121  YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR 180
            YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR
Sbjct: 121  YKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIR 180

Query: 181  FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN 240
            FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN
Sbjct: 181  FLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAEN 240

Query: 241  RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ 300
            RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ
Sbjct: 241  RKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ 300

Query: 301  DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA 360
            DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA
Sbjct: 301  DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA 360

Query: 361  QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ 420
            QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ
Sbjct: 361  QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ 420

Query: 421  EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 480
            EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ
Sbjct: 421  EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 480

Query: 481  AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 540
            AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ
Sbjct: 481  AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 540

Query: 541  QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD 600
            QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD
Sbjct: 541  QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD 600

Query: 601  AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660
            AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE
Sbjct: 601  AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660

Query: 661  TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720
            TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE
Sbjct: 661  TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720

Query: 721  EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780
            EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA
Sbjct: 721  EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780

Query: 781  ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 840
            ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE
Sbjct: 781  ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 840

Query: 841  ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 900
            ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD
Sbjct: 841  ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 900

Query: 901  DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960
            DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF
Sbjct: 901  DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960

Query: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020
            CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL
Sbjct: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020

Query: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080
            ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL
Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080

Query: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140
            EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ
Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140

Query: 1141 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
            EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ
Sbjct: 1141 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200

Query: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260
            DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260

Query: 1261 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1320
            KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE
Sbjct: 1261 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1320

Query: 1321 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
            RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR
Sbjct: 1321 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380

Query: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1440
            HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1440

Query: 1441 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS 1500
            KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS
Sbjct: 1441 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS 1500

Query: 1501 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560
            TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD
Sbjct: 1501 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560

Query: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1620
            SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH
Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1620

Query: 1621 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680
            YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV
Sbjct: 1621 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680

Query: 1681 RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 1740
            RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK
Sbjct: 1681 RSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 1740

Query: 1741 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS 1800
            LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS
Sbjct: 1741 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS 1800

Query: 1801 GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL 1860
            GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL
Sbjct: 1801 GRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARL 1860

Query: 1861 GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI 1920
            GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI
Sbjct: 1861 GSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRI 1920

Query: 1921 AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG 1980
            AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG
Sbjct: 1921 AELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTG 1980

Query: 1981 ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK 2040
            ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK
Sbjct: 1981 ITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTK 2040

Query: 2041 QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA 2100
            QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA
Sbjct: 2041 QADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATA 2100

Query: 2101 AAIGATPRAKGKAKH 2115
            AAIGATPRAKGKAKH
Sbjct: 2101 AAIGATPRAKGKAKH 2115


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 1004 VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1061

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1062 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1121

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1122 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1181 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1228

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1525

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1582

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1643 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1877

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2118 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2167

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2227 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2282

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2343 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2515 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2571

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2572 E--LQQLEQQRRQQEELLAEENQRLRE 2596



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1216 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1273

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1390

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1391 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1446

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1685

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1736

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1737 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1970

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2029

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2205

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2266 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2323

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 916  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 975

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 976  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1036 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1095

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1096 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1146

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1196

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1249

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1369

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1370 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1408

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1409 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1449

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1555

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1556 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1603

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1604 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1711

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1712 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1828 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1882

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1941

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1942 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 848  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 882

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 883  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 941

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 942  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1001

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 1002 RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1059

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1060 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1110

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1111 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1169

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1170 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1218

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1219 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1270

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1271 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1379

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1380 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1417

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1418 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1471 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1520

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1576

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1577 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1632

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1686

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1906

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1907 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1964 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 2003

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 2004 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2046

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2102

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2103 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2156

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 381  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 423

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 424  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 478

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 479  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 538

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 539  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 598

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 599  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 658

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 659  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 718

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 719  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 778

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 779  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 836

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 837  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 896

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 897  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 952

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 953  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 1009

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 1010 -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1050

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1051 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1228 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1286

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1342

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1391

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1392 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1507

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1566

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1627 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1681

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1741

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 379  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 435

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 436  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 491

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 492  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 544

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 545  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 599

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 600  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 659

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 660  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 715

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 716  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 770

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 771  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 828

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 829  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 888

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 889  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 948

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 949  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 1008

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 1009 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1068

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1069 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1188

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1189 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1249 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1360

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1535

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 1008 VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1065

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1066 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1125

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1126 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1185 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1232

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1529

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1586

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1647 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1881

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2122 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2171

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2231 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2286

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2347 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2519 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2575

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2576 E--LQQLEQQRRQQEELLAEENQRLRE 2600



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1220 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1277

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1278 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1394

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1395 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1450

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1689

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1740

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1741 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1797

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1798 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1857 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1916

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1974

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2033

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2209

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2270 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2327

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2448 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2568 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2628 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 920  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 979

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 980  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1039

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1040 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1099

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1100 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1150

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1151 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1200

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1201 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1253

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1254 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1373

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1374 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1412

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1413 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1453

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1559

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1560 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1607

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1608 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1715

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1716 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1771

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1831

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1832 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1886

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1945

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1946 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 852  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 886

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 887  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 945

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 946  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1005

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 1006 RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1063

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1064 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1114

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1115 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1173

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1174 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1222

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1223 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1274

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1275 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1334

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1383

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1384 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1421

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1422 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1475 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1524

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1580

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1581 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1636

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1690

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1744

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1804

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1910

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1911 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1968 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 2007

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 2008 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2050

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2106

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2107 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2160

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 385  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 427

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 428  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 482

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 483  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 542

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 543  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 602

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 603  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 662

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 663  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 722

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 723  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 782

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 783  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 840

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 841  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 900

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 901  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 956

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 957  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 1013

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 1014 -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1054

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1055 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1112 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1171

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1172 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1231

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1232 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1290

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1346

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1395

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1396 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1511

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1570

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1631 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1685

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1745

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 383  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 439

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 440  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 495

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 496  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 548

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 549  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 603

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 604  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 663

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 664  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 719

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 720  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 774

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 775  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 832

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 833  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 892

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 893  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 952

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 953  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 1012

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 1013 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1072

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1073 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1132

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1133 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1192

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1193 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1252

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1253 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1311

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1364

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1539

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 1004 VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1061

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1062 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1121

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1122 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1181 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1228

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1525

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1582

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1643 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1877

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2118 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2167

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2227 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2282

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2343 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2515 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2571

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2572 E--LQQLEQQRRQQEELLAEENQRLRE 2596



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1216 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1273

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1390

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1391 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1446

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1685

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1736

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1737 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1970

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2029

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2205

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2266 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2323

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 916  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 975

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 976  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1036 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1095

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1096 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1146

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1196

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1249

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1369

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1370 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1408

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1409 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1449

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1555

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1556 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1603

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1604 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1711

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1712 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1828 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1882

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1941

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1942 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 848  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 882

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 883  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 941

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 942  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1001

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 1002 RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1059

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1060 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1110

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1111 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1169

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1170 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1218

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1219 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1270

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1271 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1379

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1380 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1417

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1418 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1471 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1520

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1576

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1577 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1632

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1686

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1906

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1907 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1964 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 2003

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 2004 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2046

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2102

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2103 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2156

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 381  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 423

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 424  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 478

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 479  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 538

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 539  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 598

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 599  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 658

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 659  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 718

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 719  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 778

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 779  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 836

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 837  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 896

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 897  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 952

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 953  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 1009

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 1010 -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1050

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1051 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1228 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1286

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1342

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1391

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1392 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1507

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1566

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1627 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1681

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1741

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 379  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 435

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 436  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 491

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 492  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 544

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 545  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 599

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 600  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 659

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 660  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 715

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 716  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 770

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 771  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 828

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 829  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 888

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 889  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 948

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 949  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 1008

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 1009 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1068

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1069 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1188

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1189 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1249 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1360

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1535

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 972  VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1029

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1030 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1089

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1090 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1149 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1196

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1493

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1550

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1611 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1845

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2086 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2135

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2195 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2250

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2311 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2483 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2539

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2540 E--LQQLEQQRRQQEELLAEENQRLRE 2564



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1184 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1241

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1242 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1358

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1359 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1414

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1653

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1704

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1705 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1761

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1762 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1821 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1880

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1938

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 1997

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2173

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2234 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2291

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2412 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2532 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2592 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 884  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 943

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 944  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1003

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1004 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1063

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1064 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1114

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1115 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1164

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1165 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1217

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1218 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1337

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1338 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1376

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1377 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1417

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1523

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1524 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1571

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1572 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1679

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1680 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1735

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1795

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1796 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1850

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1909

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1910 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 816  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 850

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 851  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 909

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 910  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 969

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 970  RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1027

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1028 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1078

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1079 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1137

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1138 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1186

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1187 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1238

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1239 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1298

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1347

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1348 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1385

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1386 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1439 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1488

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1544

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1545 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1600

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1654

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1708

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1768

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1874

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1875 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1932 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 1971

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 1972 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2014

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2070

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2071 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2124

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 349  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 391

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 392  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 446

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 447  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 506

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 507  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 566

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 567  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 626

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 627  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 686

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 687  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 746

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 747  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 804

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 805  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 864

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 865  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 920

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 921  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 977

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 978  -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1018

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1019 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1076 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1135

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1136 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1195

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1196 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1254

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1310

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1359

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1360 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1475

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1534

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1595 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1649

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1709

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 347  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 403

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 404  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 459

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 460  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 512

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 513  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 567

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 568  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 627

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 628  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 683

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 684  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 738

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 739  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 796

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 797  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 856

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 857  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 916

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 917  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 976

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 977  LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1036

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1037 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1096

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1097 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1156

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1157 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1216

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1217 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1275

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1328

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1503

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 1141 VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1198

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1199 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1258

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1259 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1318 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1365

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1662

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1719

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1780 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 2014

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2255 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2304

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2305 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2364 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2419

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2480 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2652 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2708

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2709 E--LQQLEQQRRQQEELLAEENQRLRE 2733



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1353 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1410

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1527

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1528 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1583

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1822

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1873

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1874 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1930

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1931 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 2049

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 2107

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2166

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2342

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2403 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2460

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 1053 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1112

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 1113 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1172

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1173 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1232

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1233 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1283

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1284 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1333

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1334 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1386

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1506

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1507 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1545

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1546 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1586

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1692

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1693 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1740

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1741 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1848

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1849 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1904

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1964

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1965 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 2019

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 2078

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 2079 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 985  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 1019

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 1020 WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 1078

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 1079 DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1138

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 1139 RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1196

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1197 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1247

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1248 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1306

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1307 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1355

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1356 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1407

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1408 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1467

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1516

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1517 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1554

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1555 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1608 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1657

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1713

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1714 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1769

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1823

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1877

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1937

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 2043

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 2044 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 2101 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 2140

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 2141 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2183

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2239

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2240 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2293

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 518  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 560

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 561  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 615

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 616  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 675

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 676  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 735

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 736  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 795

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 796  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 855

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 856  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 915

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 916  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 973

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 974  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 1033

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 1034 QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 1089

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 1090 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 1146

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 1147 -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1187

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1188 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1245 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1304

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1305 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1364

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1365 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1423

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1479

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1528

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1529 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1644

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1703

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1764 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1818

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1878

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 516  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 572

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 573  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 628

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 629  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 681

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 682  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 736

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 737  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 796

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 797  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 852

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 853  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 907

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 908  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 965

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 966  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 1025

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 1026 DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 1085

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 1086 EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 1145

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 1146 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1205

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1206 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1325

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1326 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1385

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1386 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1444

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1497

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1672

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 982  VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1039

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1040 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1099

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1100 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1159 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1206

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1503

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1560

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1621 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1855

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2096 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2145

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2146 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2205 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2260

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2321 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2493 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2549

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2550 E--LQQLEQQRRQQEELLAEENQRLRE 2574



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1194 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1251

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1368

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1369 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1424

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1663

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1714

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1715 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1771

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1772 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1890

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1948

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2007

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2183

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2184 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2244 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2301

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2422 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2542 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2602 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 894  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 953

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 954  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1013

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1014 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1073

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1074 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1124

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1125 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1174

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1175 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1227

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1347

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1348 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1386

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1387 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1427

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1533

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1534 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1581

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1582 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1689

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1690 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1745

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1805

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1806 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1860

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1919

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1920 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 826  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 860

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 861  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 919

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 920  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 979

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 980  RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1037

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1038 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1088

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1147

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1148 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1196

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1197 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1248

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1249 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1308

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1357

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1358 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1395

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1396 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1449 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1498

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1554

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1555 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1610

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1664

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1718

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1778

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1884

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1885 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1942 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 1981

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 1982 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2024

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2080

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2081 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2134

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 359  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 401

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 456

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 457  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 516

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 517  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 576

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 577  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 636

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 637  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 696

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 697  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 757  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 814

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 815  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 874

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 875  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 930

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 931  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 987

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 988  -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1028

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1029 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1086 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1145

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1146 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1205

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1206 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1264

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1320

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1369

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1370 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1485

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1544

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1605 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1659

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1719

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 357  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 413

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 414  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 469

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 470  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 522

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 523  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 577

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 578  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 638  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 693

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 694  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 748

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 749  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 806

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 807  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 866

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 867  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 926

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 927  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 986

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 987  LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1046

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1047 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1166

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1167 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1226

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1227 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1285

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1338

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1513

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 990  VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1047

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1048 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1107

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1108 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1166

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1167 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1214

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1511

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1568

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1629 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1686

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1807 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1863

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2104 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2153

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2154 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2213 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2268

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2329 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2501 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2557

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2558 E--LQQLEQQRRQQEELLAEENQRLRE 2582



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1202 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1259

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1376

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1377 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1432

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1671

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1722

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1723 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1779

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1780 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1839 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1898

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1956

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2015

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2191

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2252 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2309

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2430 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2550 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2610 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 902  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 961

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 962  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1021

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1022 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1081

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1082 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1132

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1133 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1182

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1183 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1235

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1236 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1355

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1356 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1394

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1395 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1435

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1541

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1542 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1589

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1590 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1697

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1698 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1753

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1813

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1814 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1868

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1927

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1928 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2203



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 834  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 868

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 869  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 927

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 928  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 987

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 988  RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1045

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1046 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1096

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1097 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1155

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1156 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1204

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1205 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1256

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1257 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1316

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1365

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1366 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1403

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1404 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1457 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1506

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1562

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1563 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1618

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1672

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1726

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1786

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1892

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1893 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1950 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 1989

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 1990 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2032

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2088

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2089 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2142

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 367  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 409

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 410  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 464

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 465  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 524

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 525  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 584

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 585  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 644

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 645  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 704

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 705  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 764

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 765  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 822

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 823  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 882

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 883  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 938

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 939  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 995

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 996  -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1036

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1037 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1213

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1214 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1272

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1328

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1377

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1378 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1493

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1552

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1613 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1667

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1727

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 365  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 421

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 422  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 477

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 478  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 530

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 531  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 585

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 586  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 645

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 646  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 701

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 702  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 756

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 757  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 814

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 815  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 874

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 875  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 934

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 935  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 994

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 995  LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1054

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1055 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1114

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1115 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1174

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1175 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1234

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1235 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1293

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1346

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1521

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  289 bits (740), Expect = 2e-77
 Identities = 399/1647 (24%), Positives = 712/1647 (43%), Gaps = 220/1647 (13%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQ---IAMMQQRIDRLALLNEKQAASP 272
            + RL+  L  E +   E    +AE +K   E +     +A +    +++  L E   A+P
Sbjct: 1031 VHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1088

Query: 273  LEPKELEELRDKNESL--------------------------TMRLHET-LKQCQ----- 300
                ELE    K E +                           +R HE  LK+ Q     
Sbjct: 1089 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1148

Query: 301  --DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
              +L+  K+ + +K+   +E        LR+     Q++ + L +   E     + W E+
Sbjct: 1149 LPELEATKASL-KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1207

Query: 359  QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
             AQL +   A L        + ++ Q +L QL   L   +     E  + LG  LQ    
Sbjct: 1208 VAQLLERWQAVLA-------QTDVRQRELEQLGRQLRYYR-----ESADPLGAWLQDARR 1255

Query: 419  KQE---AATLAANNT------QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
            +QE   A  LA +        Q QA +E +E    + E      + +    K     L+T
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA--------TIQQQDQEL 521
                     S AK+   Q+      +    + +  SELTTL +        T+++ ++E 
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375

Query: 522  AGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
               +QQ  E++ +LA+    L++Q Q ++       Q     K+ +Q+++E   ++E   
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435

Query: 579  QDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAA---KLEILQQQLQVANEAR 631
             D  QQ  +  EE    R++S  E  A  +Q EA E+ +     ++ +++ QL+     R
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 632  DSAQTSVT-------QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
              A+  +        +A+ +K +   + E L+  V+   Q + +A+ ++A    ++++E 
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---RVKAEA 1552

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAET 743
            + A EK+R  Q  ++L+ Q +  +  L+  +    E  R+   ALE  QR   +EL+++ 
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAE---VERARQVQVALETAQRSAEAELQSKR 1609

Query: 744  RSLVEQHKRERKELEEERAG----RKGLEARLQQLGEAHQAETEVLRR------ELAEAM 793
             S  E+  +  + L+EE       R+  E R QQ  EA +A  E  R       +  EA+
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669

Query: 794  AAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKE----ECEKARQE 848
              +  AE   +Q  K +A A  E+ ++  + EA+     +EQ +  +E    E EK RQ 
Sbjct: 1670 RLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1727

Query: 849  LQ-EAKEKVAG----IESHSELQISRQQN-----ELAELHANLARALQQVQEKEVRAQKL 898
             +  A++++A     I   +E +   QQ      ELA L    A A Q+ QE E    K+
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1787

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA------GDRQPEWL 952
              ++  L    A   +E        ++  E +    REL +E AR         RQ +  
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847

Query: 953  EEQQGRQFCSTQAALQ---AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--- 1006
            EE   RQ    +  L    A   EA ++  E E    AL E + + +  R   E E    
Sbjct: 1848 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEKEAENERLRRLAEDEAFQR 1904

Query: 1007 ARLTQERGRAQADLA-----LEKAARAELEMR---LQNALNEQRV---EFATLQEALAHA 1055
             RL ++  + +AD+      L KA+ +ELE +   +++ L ++R    E   L+ +   A
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964

Query: 1056 LTEKEGKDQELAKLRG-----LEAAQIKELEELRQTVKQLKEQLAKKEKEHA--SGSGAQ 1108
               K   + EL ++R      L + +  ELE  RQ     +E+  ++E E        A+
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQK-QQEQADSLERSLEA-ERASRAERDSALET 1166
             EAA + +    ++E L+A+V +  +  ++ +QE A  L+ + EA ++  +AE  +    
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
            +Q + +E  Q L   QS L   + E  A R   ++  +A  + + + A+ R++ E    L
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144

Query: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
              S EE+         + +  +++L++      E  Q+   R +  QA      A  AE 
Sbjct: 2145 KQSAEEQAQAR----AQAQAAAEKLRK------EAEQEAARRAQAEQAALRQKQAADAEM 2194

Query: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
                +   Q+LR++A+ ++  +  LR +L     +   L +EL+  + +  +  +  S +
Sbjct: 2195 EKHKKFAEQTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2253

Query: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--------EELEQSKQAAGGLRAE 1398
            + E  S +  + EL   K    +++AE  A   R +        EE E+ KQ A    A 
Sbjct: 2254 EEELFSVRVQMEELSKLK---ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-AR 2309

Query: 1399 LLRAQRELGELIPLRQK-VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
            L  A +E   L  L ++ +A+Q   A+++  EK    ++ + LK    LL ++     E+
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369

Query: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRL-AEVQR--EAQSTARELEVMTAKYEG 1514
            A          L + +E+  Q+LA      +  L AE QR  E  + A  L++  A+   
Sbjct: 2370 AR--------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421

Query: 1515 AKVKVLEERQRFQEE---------RQKLTAQ-----VEQLEVFQREQTKQVEELSKKLAD 1560
            A+ +  E+ QRF+++         R +L  Q     V+ LE+ +++     E L + +A+
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481

Query: 1561 SDQASKVQQQKLKAVQAQGGESQ--------QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
             ++  +  QQ+ K +Q +  E Q        QE Q LQ      +  L Q+E+  E  K 
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541

Query: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGHELQQAGLKTKEA 1669
            ++E+      AK QQ +E  EQ R  +Q+++E + L A   EA R  HE ++ G++ K+ 
Sbjct: 2542 KLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEE-GVRRKQE 2598

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            E   + L  Q R  E  +A  +Q+LR+
Sbjct: 2599 E--LQQLEQQRRQQEELLAEENQRLRE 2623



 Score =  252 bits (644), Expect = 2e-66
 Identities = 351/1491 (23%), Positives = 634/1491 (42%), Gaps = 196/1491 (13%)

Query: 202  ASPMGDILQTPQFQMRRLKKQ-LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
            A P+G  LQ  + +  +++   LAD ++ R++L  E A   ++  E+  +     QR  +
Sbjct: 1243 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI--ERHGEKVEECQRFAK 1300

Query: 261  ----------LALLNEKQAASPL-EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ- 308
                      L L+  K    P+  P +  +++  +ES+     +      +L T  SQ 
Sbjct: 1301 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360

Query: 309  ---MDRKINQLSEENGDLSFKLREFASHLQQLQDALN---ELTEEHSKATQEWLEKQAQL 362
               +   + ++ EE      +  E    L +++ AL    +L E H++A  +  E++A  
Sbjct: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREA-- 1417

Query: 363  EKELSAALQDKKCLEEKNEI-LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
             KEL   +Q++    E+  +  Q +   ++E L QL+ +    + E+     Q E  ++ 
Sbjct: 1418 -KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAEAAERS 1473

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEE---EKQQLSSLITDLQSSISNL 478
               +      ++ ++E  E +RG  E +L A R   EE   +K+Q       L+  + + 
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 479  SQAKEELE-----------------------------QASQAHGARLTAQVASLTSELTT 509
            SQ K + E                             QA +A      A+V         
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
            L    +  + EL   +    EK AQL ++LQ++  A   LR + E+ +    + E+  +E
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653

Query: 570  VAEKQEA--TRQDHAQQLATAAEE--REASLRERDAALKQLEALEKE-----KAAKLEIL 620
               + E    + + A +L   AEE  ++ SL + +A  KQ E  E+E     KA +  + 
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVR 1712

Query: 621  QQQL--QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
            Q++L  Q   + R  A+ +  Q    + EL R           A  EQ E Q Q+ E EL
Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRL---------RAETEQGEQQRQLLEEEL 1763

Query: 679  -QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ---- 733
             +L+ E   AT+K    QE +    +++A  E L  +K   EEE R  ++  +++     
Sbjct: 1764 ARLQREAAAATQKR---QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1820

Query: 734  ---RCISELKAETRSLVEQHKRERKELEEERAGRKGLEA------RLQQLGEAHQ----- 779
               R ++E  A  R+L E+ KR+R +L EE A R+  EA      +L  +GEA +     
Sbjct: 1821 GRFRELAEEAARLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879

Query: 780  -----------------AETEVLRRELAEAMAAQHTA--ESECEQLVKEVAAWRERYEDS 820
                             AE E  +R   E  AAQH A  E    QL K   +  ER +  
Sbjct: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1939

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
             ++  +     +E+++ LK   EKA     E + ++  I S++E  +  +  E AEL A 
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEAA 1997

Query: 881  LARALQQVQEK-----EVRAQK-LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              R L   +E+     E R QK LA +    +++ AA  +EV RL+  V +A   +E A 
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAE 2056

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA---ALMES 991
            +E  ++   A +   + L+ ++     + Q   Q +++  +Q  + L++LR    A   +
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116

Query: 992  QGQQQEERGQQEREVA---RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
              + +E R Q ERE A   R  +E  R +     +  ARA+ +   +    E   E A  
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
             +A   AL +K+  D E+ K +      +++  ++ Q +  L+ QL  +E +H       
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL--EETDHQ--KNLL 2232

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS--RAERDSALET 1166
             E   R +    +    R++V +     + Q E+   L+  +EAE  +    ++D+    
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFR-----TKVQDHSKAEDEWKAQVARGRQEAE 1221
            LQ +  EK +++    + L+ A +E A  R        Q  + AE   K ++ +  QEA 
Sbjct: 2293 LQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM-QAVQEAT 2350

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLV---------MAESEKSQKLE-----E 1267
            R  +    L+++  +   Q    + + +++ + +           E+E+ ++LE     E
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410

Query: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS----------ENLRQELTS 1317
            RL+L  AE +   ARA E +   R++ + + E+  +  +A+          E  RQ+   
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470

Query: 1318 QAERAEELGQELKAWQEKFFQ-------KEQALSTLQLEH--TSTQALVSELLPAKHLCQ 1368
             AER  E   EL+  +EK  Q       K + + T+Q E     TQAL    L  K    
Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530

Query: 1369 Q----LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
            Q    ++ E+A  E+  ++E+ +++Q     + +  + ++E   L+   ++   ++  A+
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590

Query: 1425 QLRAEKASYAEQLSMLKK-AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
            +    K    +QL   ++    LLAEEN+ L E+  L  +     L  + E    ++AA 
Sbjct: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650

Query: 1484 RADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
            +     R       AE + E        +V   + + A +   EE QR  +
Sbjct: 2651 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701



 Score =  242 bits (617), Expect = 3e-63
 Identities = 356/1418 (25%), Positives = 612/1418 (43%), Gaps = 217/1418 (15%)

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQ---QEAKLLAERG------HFEEEKQQLSSL 467
            TLK E    A ++ +L  +  + +++       E +L+AER       H+++  Q L   
Sbjct: 943  TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1002

Query: 468  ITD---LQSSISNLSQAKEELE--QASQAHGARL------TAQVASLTSELTTLNATIQQ 516
              +    Q  IS L   + +LE  +    H  RL        + A   +E     A ++ 
Sbjct: 1003 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1062

Query: 517  QDQELAGLKQQAKE-----KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
              + +A L  +A++     + +  A TL+ + + + G   QV  LS+   +K + +  V 
Sbjct: 1063 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1122

Query: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
               +      A+++  A EE+    +   A L +LEA +    A L+ L+ Q +      
Sbjct: 1123 RGTQG-----AEEVLRAHEEQLKEAQAVPATLPELEATK----ASLKKLRAQAEAQQPTF 1173

Query: 632  DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
            D+ +  +  AQ     L ++  E    VE  R+       +VA+L   L   Q    + +
Sbjct: 1174 DALRDELRGAQEVGERLQQRHGERDVEVERWRE-------RVAQL---LERWQAVLAQTD 1223

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
               +E +QL  QL+  +ES       L++ +RR       Q++  +   A+++++ EQ +
Sbjct: 1224 VRQRELEQLGRQLRYYRESADPLGAWLQDARRR-------QEQIQAMPLADSQAVREQLR 1276

Query: 752  RERKELEE-ERAGRKGLEARL---QQLGEAHQAETEVL----RRELAEAMAAQHTAESEC 803
            +E+  LEE ER G K  E +    Q +      E +++    + E   + A +   +S  
Sbjct: 1277 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E +++E    R  Y +     +QY     E L  ++EE   A Q+  E +E++A +E+  
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1396

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            E     +Q +LAE HA  A+A  + + KE            LQ++M    +EV R E   
Sbjct: 1397 E-----KQRQLAEAHAQ-AKAQAEREAKE------------LQQRM---QEEVVRREEAA 1435

Query: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL-- 981
              A +Q+ +   EL                 QQ RQ  S++A +QA  R+AE        
Sbjct: 1436 VDAQQQKRSIQEEL-----------------QQLRQ--SSEAEIQAKARQAEAAERSRLR 1476

Query: 982  --ERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
              E +R   ++ +  +++  G + E +  R   E   AQ   A E+A R   +++ ++  
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 1039 NEQ-RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
              Q  VE A+  +A A A  EK+         R L+A     LEELR   ++ + +L + 
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQ---------RALQA-----LEELRLQAEEAERRLRQA 1582

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            E E A       E A R+     +L++ RA  +          E+   LERSL+ E  + 
Sbjct: 1583 EVERARQVQVALETAQRSAEA--ELQSKRASFA----------EKTAQLERSLQEEHVAV 1630

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELA--------AFRTKVQDHSKAEDEW 1209
            A+       L+ + E +AQ+   ++ A   A+REL         A R ++Q    A+ + 
Sbjct: 1631 AQ-------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1683

Query: 1210 KAQVARGRQ--EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL-- 1265
             AQ    +Q  EAER+       EE+ ++  R++ E+E E    K+  +AE    Q+L  
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQELE----KQRQLAEGTAQQRLAA 1738

Query: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS-QAERAEE 1324
            E+ L  L+AET        ++   L EE+  L+ EA       + L  EL   +AE    
Sbjct: 1739 EQELIRLRAETEQGE----QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1794

Query: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ------QLQAEQAAAE 1378
            L  + +A +E     E++   L+ E    + L  E    + L +      QL  E AA +
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854

Query: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA--------------Q 1424
            +   E +   K AA G  A  L+ + E    I L++K AE ER                +
Sbjct: 1855 RAEAERVLAEKLAAIG-EATRLKTEAE----IALKEKEAENERLRRLAEDEAFQRRRLEE 1909

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            Q    KA   E+L+ L+KA     E  +GL E     R+ +E E+   +  + ++ AA +
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAGK 1968

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----EERQRFQEER-QKLTAQVEQ 1539
            A+ E  L  ++  A+ T R  E   A+ E A+ + L    E R+R  EER QK  A  E+
Sbjct: 1969 AELELELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026

Query: 1540 LEVFQREQTKQVEELSKKL---------ADSDQASKVQ------QQKLKAVQ-AQGGESQ 1583
                ++   ++VE L  K+         A+ + A ++Q      Q++L+A + A     Q
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086

Query: 1584 QEAQRLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
            Q+ Q LQ  L + Q+ L Q   + +AA     + E+A+   + +  Q++   E+   L+Q
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146

Query: 1641 LQKENKELRAEA----ERLGHELQQAGLKTKEAEQTC-RHLTAQVRSLEAQVAHADQQLR 1695
              +E  + RA+A    E+L  E +Q   +  +AEQ   R   A    +E     A+Q LR
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
               + +     L+ +  +   Q +L  + L     E T
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2244



 Score =  236 bits (601), Expect = 2e-61
 Identities = 396/1598 (24%), Positives = 658/1598 (41%), Gaps = 244/1598 (15%)

Query: 153  KAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTP 212
            +A VPS C       + PP+ +A+  +  LE Q  A                    L T 
Sbjct: 875  EAAVPSVCFL-----VPPPNQEAQEAVTRLEAQHQA--------------------LVTL 909

Query: 213  QFQMRRLKKQLADERSNRDELEL----ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
              Q+    K L   +S R +++L     LA  R L  E+  Q A+    +   A L + Q
Sbjct: 910  WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQ-ALHSLELHYQAFLRDSQ 968

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             A    P++      +  S +    + L+  +    E+S+  R I++L +    L     
Sbjct: 969  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1028

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE------KELSAALQDKKCLEEKNEI 382
                 L+   D   E   E ++   E  + QA++E        LSA  +    L E +  
Sbjct: 1029 RTVHRLRLPLD--KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA 1086

Query: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442
                 S+LE  L +L+              + LE LK    +L    TQ    V     E
Sbjct: 1087 APTLRSELELTLGKLEQVRSLS-------AIYLEKLK--TISLVIRGTQGAEEVLRAHEE 1137

Query: 443  RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
            + ++   + A     E  K  L  L    ++        ++EL  A +  G RL  +   
Sbjct: 1138 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV-GERLQQRHGE 1196

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
               E       +++  + +A L ++    QA LAQT  +Q +  Q L  Q+     S   
Sbjct: 1197 RDVE-------VERWRERVAQLLERW---QAVLAQTDVRQRELEQ-LGRQLRYYRESADP 1245

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
                L++   +QE   Q  A  LA +   RE  LR+  A L+++E        K+E  Q+
Sbjct: 1246 LGAWLQDARRRQE---QIQAMPLADSQAVRE-QLRQEQALLEEIE----RHGEKVEECQR 1297

Query: 623  -QLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               Q  N  +D     VT +AQ E      K  ++Q+  E+  QE  + +   +EL    
Sbjct: 1298 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1357

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
                +  +E  R  +E+++L EQ +A            E E+    +A  E+QR ++E  
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAE-----------ERERLAEVEAALEKQRQLAEAH 1406

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT 798
            A+ ++   Q +RE KEL++          R+Q+         EV+RRE A  +A   + +
Sbjct: 1407 AQAKA---QAEREAKELQQ----------RMQE---------EVVRREEAAVDAQQQKRS 1444

Query: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
             + E +QL       R+  E   Q +A+     +   + ++EE    R +L+  + +  G
Sbjct: 1445 IQEELQQL-------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497

Query: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
             E   ELQ  R + E AE         +Q QE+  R ++   D S  Q K  A  +  +R
Sbjct: 1498 AEG--ELQALRARAEEAEAQK------RQAQEEAERLRRQVQDES--QRKRQAEVELASR 1547

Query: 919  LETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
            ++     A E+Q      E ++  A   +R+    E ++ RQ    Q AL+  +R AE  
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ---VQVALETAQRSAEA- 1603

Query: 978  GNELERLRAALMESQGQQQEERGQQEREVARLTQERGR-----AQADLALEKAARAELEM 1032
              EL+  RA+  E   Q +    ++   VA+L +E  R     A+A+ A E+A R ELE 
Sbjct: 1604 --ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELE- 1659

Query: 1033 RLQNALNEQ-----RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
            R Q   NE      + E    Q++LA A  EK+ ++ E       EA +  + EE     
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER------EARRRGKAEEQAVRQ 1713

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L EQ  +K+++ A G+  Q  AA +      +L  LRAE  + EQQ Q  +E+   L+
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQ------ELIRLRAETEQGEQQRQLLEEELARLQ 1767

Query: 1148 RSLEAERASRAERDSALETLQGQLE------EKAQELGHSQS--------ALASAQRELA 1193
            R   A    R E ++ L  ++ ++E       +A+E   S S        A A   RELA
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1827

Query: 1194 A----FRTKVQDHSKAEDEWKAQVARGRQEAER----KNSLISSLEEEVSILNRQVLEKE 1245
                  R   ++  +     +   AR R EAER    K + I       +     + EKE
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
             E++ L+RL   E+ + ++LEE+              AA+  + + E +  LR+ ++ + 
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQ--------------AAQHKADIEERLAQLRKASDSEL 1933

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               + L ++   Q  + EE   E+ A +  F +     + L+LE    ++   + L +K 
Sbjct: 1934 ERQKGLVEDTLRQRRQVEE---EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
                 QAE  AA +R              L AE  R +RE  E +  ++ +A +E  A+Q
Sbjct: 1991 -----QAELEAARQRQ-------------LAAEEERRRREAEERV--QKSLAAEEEAARQ 2030

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE-KYVQELAAVR 1484
             +A      E++  LK       EE R L ERA         E + AR+ +  QE A  R
Sbjct: 2031 RKAA----LEEVERLKAK----VEEARRLRERA---------EQESARQLQLAQEAAQKR 2073

Query: 1485 ADAETR-----LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
              AE +     + + ++E Q T ++ + +  +  G      E  +R  EE ++   Q E+
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA----EAARRAAEEAEEARVQAER 2129

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
                 R Q ++ E L  K +  +QA    Q +  A + +    Q+ A+R QA+    QA 
Sbjct: 2130 EAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE----QAA 2183

Query: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659
            L QK+ A    +   + A+     K Q  QEL      LE+   +   L  E +RL  E 
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243

Query: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             +A  +  + E+    +  Q+  L    A  + + R L
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281



 Score =  159 bits (403), Expect = 2e-38
 Identities = 347/1497 (23%), Positives = 590/1497 (39%), Gaps = 227/1497 (15%)

Query: 363  EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
            EK+L +  +  +CL+     LQ +    EE L+Q              D L    L+ + 
Sbjct: 408  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ-------------ADAL----LQSDV 450

Query: 423  ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
              LAA     +A     + ++     +LL     F + +          +     + +  
Sbjct: 451  RLLAAGKVPQRAGEVERDLDKADSMIRLL-----FNDVQTLKDGRHPQGEQMYRRVYRLH 505

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA-GLKQQAKEKQAQLAQTLQQ 541
            E L      +  RL A VA+  +++  +     Q+  EL     +  ++  A + +   +
Sbjct: 506  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 565

Query: 542  QEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREAS---- 595
             + A  G+    VE    S +   Q ++E   K E  R D  Q   AT    R+      
Sbjct: 566  VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLD 625

Query: 596  ------LRERDAALKQLEALEKEKAAKLEIL-----QQQLQVANEARD------SAQTSV 638
                  L    A L+ LE+L    AA  + L     +++ +V  +  D      + + S 
Sbjct: 626  LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685

Query: 639  TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---------KATE 689
            +   RE     +K++ELQ   +   +E H A+  V   +  L+++           +A  
Sbjct: 686  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745

Query: 690  KERVA-----QEKDQLQEQLQALKESLK--------VTKGSLEEEKRRAADA---LEEQQ 733
            KE  A      +  + + QLQ L+E+L+         T   LE+  + A D    L E +
Sbjct: 746  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 805

Query: 734  RCISELKAETRSLVEQHKRE-----RKEL---------EEERAGRKGLEARLQQLGEAHQ 779
              +S L    +++V+   R      R  L         + E    KG E +L  +G A  
Sbjct: 806  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL--VGPAQP 863

Query: 780  AETEVLRRELAEA----------------------MAAQHTA-ESECEQL---VKEVAAW 813
            +  +VL    +EA                      + AQH A  +   QL   +K + AW
Sbjct: 864  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 923

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLK-EECEKARQELQ-------EAKEKVAGIESHSEL 865
            +    D Q   +   A F+    TLK EE  +A   L+          +   G      L
Sbjct: 924  QSLRRDVQLIRSWSLATFR----TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 979

Query: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM-AATSKEVARLETLVR 924
               R+    +  +  L ++L+Q  ++E R Q+   +L  ++ ++ A  ++ V RL     
Sbjct: 980  MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL--- 1036

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
                        L KEPAR   ++   + EQQ       QA ++ + +   ++  E E++
Sbjct: 1037 -----------PLDKEPARECAQR---IAEQQ-----KAQAEVEGLGKGVARLSAEAEKV 1077

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRV 1043
              AL E        R + E  + +L  E+ R+ + + LEK     L +R  Q A    R 
Sbjct: 1078 -LALPEPSPAAPTLRSELELTLGKL--EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1134

Query: 1044 EFATLQEALA--HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
                L+EA A    L E E     L KLR    AQ    + LR  ++  +E   + ++ H
Sbjct: 1135 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1194

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRA-------EVSKLEQQCQKQQEQADSLERSLEAER 1154
                        R      + +A+ A       E+ +L +Q +  +E AD L   L+  R
Sbjct: 1195 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1254

Query: 1155 ASRAERDSALETLQGQL------EEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
              R E+  A+     Q       +E+A  +E+      +   QR    +   ++D+    
Sbjct: 1255 R-RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1313

Query: 1207 DEWKAQ---VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ 1263
              +KAQ   VA   ++ + ++   S ++E V +           S+ +K +    SE  +
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI----SETLR 1369

Query: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
            ++EE  RL + + A    R AE  +AL           EKQR  +E   Q        A+
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAEREAK 1418

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
            EL Q +   QE+  ++E+A    Q +  S Q  + +L  +     Q +A QA A +R R 
Sbjct: 1419 ELQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475

Query: 1384 -----------ELEQSKQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAE- 1429
                       +LE +++  GG   EL  LRA+ E  E    RQ   E ER  +Q++ E 
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA-QKRQAQEEAERLRRQVQDES 1534

Query: 1430 ---KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
               + +  E  S +K       E+ R L     L  Q  E E  + R+  V+    V+  
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER-RLRQAEVERARQVQVA 1593

Query: 1487 AETRLAEVQREAQSTARELEVMTAKYEG-------AKVKVLEERQR-FQEERQKLTAQVE 1538
             ET     + E QS        TA+ E        A  ++ EE +R  Q++ +   A+ E
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
                 +R Q K  E L  +L    QA +V QQK  A QA+  + ++EA+R   +  + + 
Sbjct: 1654 AERELERWQLKANEALRLRL----QAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKAEE 1708

Query: 1599 Q-LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            Q + Q+E A +  + Q + A+     +    QEL       EQ +++ + L  E  RL  
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1768

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR---DLGKFQVATDALKSRE 1711
            E   A  K +E E     + A++  L A  A A+++ R   +  K ++  +A + RE
Sbjct: 1769 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 274/1240 (22%), Positives = 492/1240 (39%), Gaps = 241/1240 (19%)

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
            E+E+  + + +  E LQ +   L++  G  EE+  +A   L+   R ++  K   R+   
Sbjct: 406  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA--- 462

Query: 749  QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQ 805
                  ++L++  +  + L   +Q L +    + E + R    L E + A  T  +   +
Sbjct: 463  --GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYN--LR 518

Query: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL----QEAKEKVAGIES 861
            L   VAA          + AQ      ++   L++   +  Q+L    +E + +V G E 
Sbjct: 519  LKAGVAA-------PATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 571

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
              +L     Q      H  L +++++ + K  RA+     LS       A    + RL+ 
Sbjct: 572  GVDLPSVEAQ---LGSHRGLHQSIEEFRAKIERARSDEGQLSPATR--GAYRDCLGRLDL 626

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAE 975
               K     +    S E +     A  ++  WL    EE+ G  +      + A +    
Sbjct: 627  QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 686

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
             +  ELE     + E   Q   +R  +E   AR T E    QA L  + +   +L   ++
Sbjct: 687  ALMRELELKEKKIKEL--QNAGDRLLREDHPARPTVE--SFQAALQTQWSWMLQLCCCIE 742

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQEL-----AKLRGLEAAQIKELEELRQTVKQL 1090
              L E    F    +     + E EG+ Q+L      K     +A +  LE+L Q  +  
Sbjct: 743  AHLKENAAYFQFFSD-----VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 797

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--------------QQC 1136
            KEQL  + K H SG   +++A  + +P  P    +R  +  L                +C
Sbjct: 798  KEQL-NEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCDYKQVEVTVHKGDEC 855

Query: 1137 QKQQEQADSLERSLEA----------------------ERASRAE-RDSALETLQGQLEE 1173
            Q       S  + L +                      E  +R E +  AL TL  QL  
Sbjct: 856  QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHV 915

Query: 1174 KAQELGHSQSALASAQR----ELAAFRT-KVQDHSKA----EDEWKA-----QVARG--- 1216
              + L   QS     Q      LA FRT K ++  +A    E  ++A     Q A G   
Sbjct: 916  DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 975

Query: 1217 --RQEAERKNSLISSLEEEVSILNRQVLEKEGESK----ELKRLVMAESEKSQKLEERLR 1270
              R  AER+    S   +++     Q  ++E   +    ELK + +       +   RLR
Sbjct: 976  EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 1035

Query: 1271 L-LQAETASNSARAAERSSALREEVQSL-----REEAEKQRV--------ASENLRQELT 1316
            L L  E A   A+        + EV+ L     R  AE ++V        A+  LR EL 
Sbjct: 1036 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1095

Query: 1317 SQAERAEEL----------------------GQE--LKAWQEKFFQKEQALSTL-QLEHT 1351
                + E++                      G E  L+A +E+  + +   +TL +LE T
Sbjct: 1096 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155

Query: 1352 ST----------------QALVSELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAA 1392
                               AL  EL  A+ + ++LQ    E+    +R RE + Q  +  
Sbjct: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1215

Query: 1393 GGLRAELLRAQRELGEL-----------IPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
              + A+    QREL +L            PL   + +  R  +Q++A   + ++ +    
Sbjct: 1216 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1275

Query: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQR 1496
            +    L EE    GE+    ++F +  ++  ++ Y  +L   +A  E      +  +VQ 
Sbjct: 1276 RQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQS 1334

Query: 1497 EAQSTAR----------ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
             ++S  +          EL  +T++Y    +K + E  R  EE ++L    EQ    +RE
Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQY----IKFISETLRRMEEEERL---AEQQRAEERE 1387

Query: 1547 QTKQVE---ELSKKLADSDQASKVQ--------QQKLKA-----------VQAQGGESQQ 1584
            +  +VE   E  ++LA++   +K Q        QQ+++             Q Q    Q+
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447

Query: 1585 EAQRL-QAQLNELQAQLSQKEQAAEHYKLQMEK----AKTHYDAKKQQNQELQEQLRSL- 1638
            E Q+L Q+   E+QA+  Q E AAE  +L++E+     +   +A ++Q    + +L++L 
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506

Query: 1639 ---EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ-L 1694
               E+ + + ++ + EAERL  ++Q    + ++AE     L ++V++ EA+ A   Q+ L
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV---ELASRVKA-EAEAAREKQRAL 1562

Query: 1695 RDLGKFQVATDALKSREPQAK----PQLDLSIDSLDLSCE 1730
            + L + ++  +  + R  QA+     Q+ +++++   S E
Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  282 bits (722), Expect = 2e-75
 Identities = 421/1752 (24%), Positives = 739/1752 (42%), Gaps = 295/1752 (16%)

Query: 207  DILQTPQFQMRRLKKQL--------ADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258
            ++L+   +++RR+  +L          +   ++EL L + E  +L        A   + +
Sbjct: 480  EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL 539

Query: 259  DRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD----LKTEKSQMDRKIN 314
              L  L E   +S LE + L + + +  +   R  +++ +       LKTE + +     
Sbjct: 540  SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599

Query: 315  QLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKK 374
            +LS  N  L+         L QL++    +      A Q     +  L+ +L+ A + ++
Sbjct: 600  KLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA----RNALQVDLAEAEKRRE 655

Query: 375  CLEEKNEILQGKLSQLEEHLSQLQDN--PPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
             L EKN  L+ +L + EE  ++LQ +    QE+ E +   L     +QEAAT        
Sbjct: 656  ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715

Query: 433  QA-RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE----Q 487
            +A R E +     Q++  L+ E+   E   Q +     DL   +  LS AKE LE    +
Sbjct: 716  EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775

Query: 488  ASQAHGA------RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541
            A Q +        +L  Q+ ++T     +   ++    EL   + QA++++   A+ L Q
Sbjct: 776  AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ 835

Query: 542  QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDA 601
             EQ  +        L       E+++ ++ EK E  R  H Q+LA A E  E    E + 
Sbjct: 836  AEQEGK------TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM 889

Query: 602  ALKQ----LEAL----------------------EKEKAAKLE-ILQQQLQVAN------ 628
             LK+    +EA+                      EKE+ + LE +LQ Q ++A+      
Sbjct: 890  RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949

Query: 629  --------------EARDSAQTSVTQAQREKAELSRKVEE----LQACVETARQEQHEAQ 670
                          E     QT + +AQRE  E +R+  +    LQ    +  Q++ + Q
Sbjct: 950  RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009

Query: 671  AQVAELELQL-------RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
             QV +L+ QL       R  +Q+  EK R  QE +++Q++L+  K SL  T   +E+E+R
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL--TLSLMEKEQR 1067

Query: 724  ----RAADALEEQQ-----RCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774
                + AD++ +Q+     + + E + E + L  Q +  R+E++E+ A     EA+L + 
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127

Query: 775  GEAHQAETEVLRREL--AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ 832
             EA     + LR  L   EA AAQ        +   E  A  ++  +  Q +AQ  +++ 
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS 1187

Query: 833  EQLMTLKEECEKARQELQ---EAKEKVAGIE--SHSELQISRQQNELAELHAN-LARALQ 886
                 L   CE +R EL    ++   V G+E   +    + ++   L  L A  +A AL 
Sbjct: 1188 ALQQALGSVCE-SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH 1246

Query: 887  QVQEKEVRAQK----LADDLSTLQEKMAATSKEVARLET----LVRKAGEQQETASRELV 938
            ++ +   + Q+    L D +  L+E++  T  E +++ T    L R+  + QE  S+   
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306

Query: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ---------MGNELERLRAALM 989
            K+ +   +   E  E     Q    +A LQ ME + E+         +  ++E L+AA++
Sbjct: 1307 KQNSLESELM-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365

Query: 990  ESQGQQQ-----EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
            E++ Q       EE  +  R   +L  E   ++ + A     + EL++    AL E    
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN--- 1422

Query: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASG 1104
             A L + LA        +++E+  LRG    QI+ELE+ R+  K   E L+   K+    
Sbjct: 1423 LALLTQTLAE-------REEEVETLRG----QIQELEKQREMQKAALELLSLDLKKRNQE 1471

Query: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER-------ASR 1157
               Q E     E     LE L   V + EQ+   Q+EQ   LE+  E +R          
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531

Query: 1158 AERDSALETLQGQLEEK----------AQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207
             ++D  +E+ +GQ+++           A EL  +   +   Q+ +     + +    A  
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591

Query: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESK-------ELKRL------ 1254
                 +    QE + ++S I  LE   ++L R++ E++ E K       EL+R       
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651

Query: 1255 --------VMAESEKSQKLEER----LRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
                    +M + E+ Q LE++     ++L+ +         ER   L  + Q ++E AE
Sbjct: 1652 DLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE 1711

Query: 1303 K-------QRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
            +       QR + E+++  L  + +  E   + +   QE   Q EQ L  L  +   T  
Sbjct: 1712 EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL 1771

Query: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG----ELIP 1411
            L+S          Q + E    +++ +E  EQ +     L+++L  AQR L     EL  
Sbjct: 1772 LLS----------QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821

Query: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD- 1470
            L+Q+  +Q+   Q+ R ++ + A Q   L++AH  L E +  L +     R+ LE EL  
Sbjct: 1822 LQQE--QQQAQGQEERVKEKADALQ-GALEQAHMTLKERHGELQDHKEQARR-LEEELAV 1877

Query: 1471 -----QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVK---VLEE 1522
                 QA E+ + +L A   + E  L  +Q++    A+E EV T   + + ++   VL+E
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937

Query: 1523 RQ-------------RFQEERQKLTAQV---------------EQLEVFQREQTKQVEEL 1554
            R              R QEE  +  A+                EQ  + Q E ++ +E  
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997

Query: 1555 SKKLADSDQASKVQQQKLK-AVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQ 1613
            +  L  S  A +   ++L+ A++ Q GE Q +  R Q  + +LQ  L+Q+++   H    
Sbjct: 1998 TATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH---- 2053

Query: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673
                       +Q+ ++L E  +SL Q  +EN  +  E + LG E +         E+  
Sbjct: 2054 -----------QQEREQLLE--KSLAQRVQEN--MIQEKQNLGQERE---------EEEI 2089

Query: 1674 RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
            R L   VR L+  +A  +Q++ +L            RE Q +  L+    S   S  E  
Sbjct: 2090 RGLHQSVRELQLTLAQKEQEILEL------------RETQQRNNLEALPHSHKTSPMEEQ 2137

Query: 1734 PLSITSKLPRTQ 1745
             L + S  PR Q
Sbjct: 2138 SLKLDSLEPRLQ 2149



 Score =  269 bits (688), Expect = 2e-71
 Identities = 396/1675 (23%), Positives = 712/1675 (42%), Gaps = 253/1675 (15%)

Query: 232  ELELELAENRK----LLTEKDAQIAMMQQRIDRL-ALLNEKQAASPLEPKELEELRDKNE 286
            ELE E  E  +    L ++ D + A +Q R+  L ALL + Q  +    K ++ LR+  E
Sbjct: 255  ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314

Query: 287  SLTMRLHETL-------KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL-- 337
             L     E +       +  Q+ K    Q+ + I Q+  E GD    + + + H   L  
Sbjct: 315  ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGD---NIAQGSGHENSLEL 371

Query: 338  ----------QDALNELTEEHS------KATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381
                      QDA   LT   S      +A Q+  ++ A  ++ ++   Q     EE+ +
Sbjct: 372  DSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431

Query: 382  ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL----------------QLETLKQEAATL 425
             L+ +L +L      L       +GEV  D L                QLE L+QEA  L
Sbjct: 432  ALRQRLQKLTGERDTLAGQTVDLQGEV--DSLSKERELLQKAREELRQQLEVLEQEAWRL 489

Query: 426  AANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL 485
               N +LQ + +  + ++ +Q+ +L       E  ++ L  L      S+S L   +E L
Sbjct: 490  RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549

Query: 486  EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA 545
            E +S   G  L  +   +T+ L    A  +Q   EL+  +   K + A L     +    
Sbjct: 550  E-SSHLEGELLRQEQTEVTAAL----ARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL 604

Query: 546  SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD-HAQQLATA-AEEREASLRERDAAL 603
            ++ L      L+  L Q E++ + V  + EA  Q  +A Q+  A AE+R  +L E++  L
Sbjct: 605  NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL 664

Query: 604  KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663
            +    L+K + A  E LQ  L+   E ++  Q  +++++ ++   + ++E+L    E  R
Sbjct: 665  EA--QLQKAEEAGAE-LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ--EAKR 719

Query: 664  QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES------------- 710
            QE+  A+A V E E  +R +       + V +++  L EQLQ L  +             
Sbjct: 720  QEEVLARA-VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778

Query: 711  ----LKVTKGSLEEEKR---RAADALEEQQRCIS------------ELKAETRSLVEQHK 751
                ++VTKG LE + +   +A + ++ + RC+             E  A  R L +  +
Sbjct: 779  QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838

Query: 752  RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
              +  LE+++A     E  + QL E  + E    ++ELA+A+ +    + E E  +KE  
Sbjct: 839  EGKTALEQQKAAH---EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895

Query: 812  AWRERYEDSQQEEAQYG--AMFQEQLMTLKEECE------KARQELQEAKEKVAGIESHS 863
               E  +  ++EE      A+ Q QL T KE         + ++EL +A +++  +    
Sbjct: 896  TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
            ++Q  ++Q     L   L  A ++++E    A++  DDL+ LQE+ ++  ++   L+  V
Sbjct: 956  KVQKLKEQETTGILQTQLQEAQRELKEA---ARQHRDDLAALQEESSSLLQDKMDLQKQV 1012

Query: 924  RKAGEQ--QETASRELVKEPARAGDRQPEW---LEEQQGRQFCSTQAALQAMER------ 972
                 Q   +  S+ LV++  +   R+ +    ++++  R+  S   +L   E+      
Sbjct: 1013 EDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072

Query: 973  EAEQMGN-ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAE-- 1029
            EA+ +   EL  LR  + E+QG+Q+E   Q E     L QE    +AD   ++A   E  
Sbjct: 1073 EADSIRQQELSALRQDMQEAQGEQKELSAQMEL----LRQEVKEKEADFLAQEAQLLEEL 1128

Query: 1030 -----LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
                  E +L+ +L  Q  + A LQ  L    ++ E    E  +  G +A    +L  L 
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQAQAQAQLASLY 1186

Query: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT----------GPKLEALRAE-----V 1129
              ++Q    + +   E  SG G  + +    EP           GP L AL AE     +
Sbjct: 1187 SALQQALGSVCESRPE-LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASAL 1245

Query: 1130 SKLEQQCQKQQE-------QADSLERSLEAERASRAERDSALETLQGQL----EEKAQ-- 1176
             KL Q   K Q+       Q   LE  L    A +++  + L+ LQ QL    EEK++  
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE 1305

Query: 1177 -----------ELGHSQSALASAQRELAAFRTKVQDHSK----AEDEWKAQVARGRQ--- 1218
                       EL  + ++L S  R     R + Q   +    A++   AQV   +    
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365

Query: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL------- 1271
            EA  + S    LEE++    R  L+ + E  E      +E E++Q L+E+  L       
Sbjct: 1366 EARAQASAAGILEEDLRTA-RSALKLKNEEVE------SERERAQALQEQGELKVAQGKA 1418

Query: 1272 LQAETASNSARAAERSS---ALREEVQSLREEAEKQRVASENL-------RQELTSQAER 1321
            LQ   A  +   AER      LR ++Q L ++ E Q+ A E L        QE+  Q E+
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478

Query: 1322 AEELGQ-----------ELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370
             +EL +             +  Q+   Q+EQ     +   T    L  +LL  +   Q +
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538

Query: 1371 QAEQAAAEKRHRE---------ELEQS--KQAAGGLRAELLRAQRELGELIPLRQKVAEQ 1419
            ++++   +   ++         ELE++  K        + L  QRE  + + L     + 
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRET-QRVALTHLTLDL 1597

Query: 1420 ERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQE 1479
            E  +Q+L+A+ +    Q+  L+    +LA E +   +     R+ +E EL + +E   Q+
Sbjct: 1598 EERSQELQAQSS----QIHDLESHSTVLARELQERDQEVKSQREQIE-ELQRQKEHLTQD 1652

Query: 1480 LAAVRADAETRLAE--VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537
            L   R D E  L +  +Q       R+ +++    E  K+ + E  +    +RQ +  + 
Sbjct: 1653 LE--RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597
            E+ +   + Q   +E +   L D ++  + QQ+ +  +Q    + +Q+ Q L  ++ E  
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770

Query: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKK---------------QQNQELQEQLRSLEQLQ 1642
              LSQ+EQ     + Q+++A+   + K+               Q++QEL+   +  +Q Q
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830

Query: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
             + + ++ +A+ L   L+QA +  KE     +    Q R LE ++A   ++++ L
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885



 Score =  238 bits (608), Expect = 4e-62
 Identities = 371/1645 (22%), Positives = 703/1645 (42%), Gaps = 221/1645 (13%)

Query: 113  PRDWEQFEYKIQAELAVILKFVLDHEDGL-NLNEDLENFLQKAPVPSTCSSTFPEELSPP 171
            P+ WE  E     EL V L+      + L  +N  L   ++KA V +       E+L+  
Sbjct: 85   PQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVD 144

Query: 172  SHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRD 231
              +A+ E+   E Q          +L G     +    +   F+   L+ + A   ++RD
Sbjct: 145  WSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSA---TDRD 201

Query: 232  ELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPL---EPKELEELRDKNESL 288
             +EL+ AE+ +L       +     R+   A   E   +  +   EP +L  L  K + L
Sbjct: 202  LMELK-AEHVRL----SGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256

Query: 289  TMRLHETLKQCQDLKT----EKSQMDRKINQLS-------EENGDLSFKLREFASHLQQL 337
                HE  ++   LK+    EK+++  ++ +LS       ++N D    ++     ++ L
Sbjct: 257  EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316

Query: 338  QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK--LSQLEEHLS 395
            +    EL E  +  ++   E++  L++ +    Q    +EE + I QG    + LE   S
Sbjct: 317  ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ--VMVEEGDNIAQGSGHENSLELDSS 374

Query: 396  QLQDNPPQEKGEVLGDVLQLETLKQEAAT-LAANNTQLQARVEMLETERGQQEAKLLAER 454
                   Q+  + L  V  + T +++A   L       Q  V +L+ +  Q E +  A R
Sbjct: 375  IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434

Query: 455  GHFEE---EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE---LT 508
               ++   E+  L+    DLQ  + +LS+ +E L++A +     L  Q+  L  E   L 
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE----ELRQQLEVLEQEAWRLR 490

Query: 509  TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
             +N  +Q Q     G K+   E+Q +L   ++++E+  + L      +    KQ E  L 
Sbjct: 491  RVNVELQLQGDSAQGQKE---EQQEELHLAVRERERLQEML------MGLEAKQSES-LS 540

Query: 569  EVAEKQEATRQDHAQQLATAAEERE--ASLRERDAALKQLEALE---KEKAAKLEILQQQ 623
            E+   +EA    H +      E+ E  A+L   + ++ +L + E   K + A L     +
Sbjct: 541  ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600

Query: 624  LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683
            L   NEA    +  + Q   +  +L  + + + + +E A Q ++  Q  +AE E +    
Sbjct: 601  LSALNEALALDKVGLNQ---QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR---- 653

Query: 684  QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
                  +E + ++   L+ QLQ  +E+                          +EL+A+ 
Sbjct: 654  ------REALWEKNTHLEAQLQKAEEAG-------------------------AELQADL 682

Query: 744  RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803
            R + E+ +  +K+L E R  ++    +L+QL +  + + EVL R           A  E 
Sbjct: 683  RDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR-----------AVQEK 731

Query: 804  EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
            E LV+E AA   R +  +++         EQL  L    E     L EA+++      +S
Sbjct: 732  EALVREKAALEVRLQAVERDRQDLA----EQLQGLSSAKELLESSLFEAQQQ------NS 781

Query: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL--STLQEKMAATSKEVARLET 921
             +++++ Q    E+        ++V + EVR  KL  D   S  +++  A ++++A+ E 
Sbjct: 782  VIEVTKGQ---LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838

Query: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
              + A EQQ+ A  + V +     +++  W +++  +       AL+++ERE  ++   L
Sbjct: 839  EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK-------ALESLEREKMELEMRL 891

Query: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
            +  +  +   Q Q++EER Q E  +          Q  L  EK   + LE  LQ    ++
Sbjct: 892  KEQQTEMEAIQAQREEERTQAESALC---------QMQLETEKERVSLLETLLQT--QKE 940

Query: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE-ELRQTVKQLKEQLAKKEKE 1100
              + +   E L   +  ++ K+QE     G+   Q++E + EL++  +Q ++ LA  ++E
Sbjct: 941  LADASQQLERLRQDMKVQKLKEQETT---GILQTQLQEAQRELKEAARQHRDDLAALQEE 997

Query: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ---KQQEQADSLERSLEAERASR 1157
             +S    + +   + E    +L A       +EQ+ Q   ++ ++ + +++ LE E+AS 
Sbjct: 998  SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS- 1056

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR 1217
                     L   L EK Q L   Q A +  Q+EL+A R  +Q+            A+G 
Sbjct: 1057 ---------LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE------------AQGE 1095

Query: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277
            Q+          L  ++ +L ++V EKE +    +  ++ E E S   E++LR   A   
Sbjct: 1096 QK---------ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR---ASLW 1143

Query: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERA--EELGQELKAWQEK 1335
            +  A+AA+    LR     L   A +Q+  ++   Q   +    A  + LG   ++  E 
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPEL 1203

Query: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQ-AAAEKRHREELEQSKQAAGG 1394
                + A S   LE     A    L     L   L AE  A+A  +  ++L +++Q    
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGA--RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261

Query: 1395 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1454
            LR ++ +          L +++ + E    Q+  E      QLS  ++      E+++  
Sbjct: 1262 LRDQVQK----------LEERLTDTEAEKSQVHTELQDLQRQLSQNQE------EKSKWE 1305

Query: 1455 GERANLGRQFLEVELDQAREKYV---QELAAVRADAETRLAEVQRE---AQSTARELEVM 1508
            G++ +L  + +E+    A  +      EL  + A  E  L +  +E   AQ    +  V+
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365

Query: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK-KLADSDQASKV 1567
             A+ + +   +LEE  R    R  L  + E++E  +RE+ + ++E  + K+A      K 
Sbjct: 1366 EARAQASAAGILEEDLR--TARSALKLKNEEVES-ERERAQALQEQGELKVAQG----KA 1418

Query: 1568 QQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ 1627
             Q+ L  +     E ++E + L+ Q+ EL+ Q   ++ A E   L ++K     D +++Q
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478

Query: 1628 NQELQEQLRSLEQL----QKENKELRAEAERLGHELQQAGLKTKEAEQ-TCRHLTAQVRS 1682
             QEL++    LE L    Q+  ++L  + E++  EL+    K +E ++    H   ++  
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQI-RELE----KDRETQRNVLEHQLLELEK 1533

Query: 1683 LEAQVAHADQQLRDLGKFQVATDAL 1707
             +  +     Q++DL K  V  + L
Sbjct: 1534 KDQMIESQRGQVQDLKKQLVTLECL 1558



 Score =  228 bits (582), Expect = 4e-59
 Identities = 381/1669 (22%), Positives = 700/1669 (41%), Gaps = 234/1669 (14%)

Query: 167  ELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQ-------FQMRRL 219
            EL     QA++E      Q   +   G   L    A+   ++ Q  +       +  + L
Sbjct: 814  ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873

Query: 220  KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE 279
             K L      + ELE+ L E +   TE +A  A  ++           QA S L   +LE
Sbjct: 874  AKALESLEREKMELEMRLKEQQ---TEMEAIQAQREEE--------RTQAESALCQMQLE 922

Query: 280  ELRDKNESLTMRLHETLKQCQDL--KTEKSQMDRKINQLSEEN--GDLSFKLREFASHLQ 335
              +++  SL   L +T K+  D   + E+ + D K+ +L E+   G L  +L+E    L+
Sbjct: 923  TEKER-VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981

Query: 336  ----QLQDALNELTEEHSKATQEWLEKQAQLE--KELSAALQDKKCLEEKNEILQGKLSQ 389
                Q +D L  L EE S   Q+ ++ Q Q+E  K    A  D + L E+   +Q KL +
Sbjct: 982  EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQE--VQEKLRE 1039

Query: 390  LEEHLSQLQDNPPQEKGEVLGDVLQ------------------LETLKQEAATLAANNTQ 431
             +E+ +++Q    +EK  +   +++                  L  L+Q+         +
Sbjct: 1040 TQEY-NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098

Query: 432  LQARVEMLETERGQQEAKLLAERGHFEEE-------KQQLSSLITDLQSSISNL------ 478
            L A++E+L  E  ++EA  LA+     EE       +QQL + +   ++  + L      
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158

Query: 479  SQAKEELEQASQAHG--ARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAK-----EK 531
            ++++ E   A Q  G  A+  AQ+ASL S L     ++ +   EL+G    A      E 
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP 1218

Query: 532  QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
                A++L ++      L    E ++S+L +  Q L +  + ++  R D  Q+L     +
Sbjct: 1219 DQNGARSLFKRGPLLTAL--SAEAVASALHKLHQDLWKTQQTRDVLR-DQVQKLEERLTD 1275

Query: 592  REASLRERDAAL----KQLEALEKEKA---AKLEILQQQLQVANEARDSAQTSVTQAQRE 644
             EA   +    L    +QL   ++EK+    K   L+ +L   +E   S Q+ + +A+ +
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335

Query: 645  KAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS----EQQKATEKERVAQEKDQL 700
            + E   + E LQA  E    +    QA V E   Q  +    E+   T +  +  + +++
Sbjct: 1336 RMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEV 1395

Query: 701  Q---EQLQALKES--LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
            +   E+ QAL+E   LKV +G           AL+E    +++  AE    VE  + + +
Sbjct: 1396 ESERERAQALQEQGELKVAQGK----------ALQENLALLTQTLAEREEEVETLRGQIQ 1445

Query: 756  ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES---ECEQLVKEVAA 812
            ELE++R  +K     L    +    E ++ + ++ E    +   E      ++  +++  
Sbjct: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV 1505

Query: 813  WRERYEDSQQEEAQYGAMFQEQLMTLKEE---CEKARQELQEAKEKVAGIESHSELQISR 869
             RE+  + +++      + + QL+ L+++    E  R ++Q+ K+++  +E  + L++  
Sbjct: 1506 QREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLA-LELEE 1564

Query: 870  QQNELAELHANLARALQ-QVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET----LVR 924
              +++ E    L + L+ Q + + V    L  DL    +++ A S ++  LE+    L R
Sbjct: 1565 NHHKM-ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR 1623

Query: 925  KAGE--QQETASRELVKEPARAGDR-----------------QPEWLEEQQGRQFCSTQA 965
            +  E  Q+  + RE ++E  R  +                  + + LE+Q+ RQ    + 
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683

Query: 966  ALQAMEREAEQMGNELERLRAALME----SQGQQQEERGQQE--REVARLTQERGRAQAD 1019
             L+ ++    + G EL   R  + E     +G  + +RG  E  + + R  ++    Q +
Sbjct: 1684 DLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE 1743

Query: 1020 LALE-KAARAELEMRLQNA----------LNEQRVEFATLQEALAHALTEKEGKDQ---- 1064
               E +  + +LE +LQ            L+++  E   LQ+ L  A  + E K+Q    
Sbjct: 1744 HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS 1803

Query: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
            +L + +   A + +ELE L+Q  +Q + Q  + +++  +  GA  +A    +    +L+ 
Sbjct: 1804 QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863

Query: 1125 LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG----- 1179
             + +  +LE++   +  +  +LE  L   RA   E++ AL  LQ Q  E+AQE       
Sbjct: 1864 HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923

Query: 1180 ------HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233
                   +Q+ L    +EL A R + Q     E+  +A+    ++   + ++ +   E+ 
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983

Query: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR----------- 1282
            +          E  +  L+  + A    S++LEE LR+ + E      R           
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043

Query: 1283 AAERSSALR--EEVQSLREEAEKQRVASENLRQELTSQAERAEE----LGQELKAWQEKF 1336
             A+R   LR  +E + L E++  QRV    ++++     ER EE    L Q ++  Q   
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103

Query: 1337 FQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQA---AAEKRHREELEQSKQAAG 1393
             QKEQ +  L+L  T  Q    E LP  H    ++ +     + E R + ELE       
Sbjct: 2104 AQKEQEI--LELRETQ-QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELE------- 2153

Query: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRG 1453
              R +    Q E  E I  R+K  +   +  Q +A  +S  E    L+ +      E + 
Sbjct: 2154 --RLQAALRQTEARE-IEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQR 2210

Query: 1454 LGERANLGRQFLEVE-LDQAREKYVQELAAVRADAETRLAEVQ----------REAQSTA 1502
            L +   L R+ LE E L         EL + R +   +L EV            E QS  
Sbjct: 2211 LQDELELTRRALEKERLHSPGATSTAELGS-RGEQGVQLGEVSGVEAEPSPDGMEKQSWR 2269

Query: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE----VFQREQTKQVEELSKKL 1558
            + LE +    + A  ++  +R R Q    +L + +EQ+E      +RE  +  +  S ++
Sbjct: 2270 QRLEHL----QQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI 2325

Query: 1559 ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY-----KLQ 1613
            + +  +S  QQ      + Q     +    LQ ++  LQAQL+ + +  + Y     +  
Sbjct: 2326 SKATASSPTQQDG----RGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381

Query: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
             E A  H+         L   L ++ Q   E   L AE  RL   L Q+
Sbjct: 2382 RELAGLHH--------SLSHSLLAVAQ-APEATVLEAETRRLDESLTQS 2421


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  262 bits (669), Expect = 3e-69
 Identities = 367/1574 (23%), Positives = 672/1574 (42%), Gaps = 183/1574 (11%)

Query: 210  QTPQFQMRRLKKQLA-DERSNRDE--LELELAENRKLLTEKDAQIAMMQQ--RIDRLALL 264
            +T + +  R K+QL  D+   R E  L+LE  E R+    ++ Q+   Q+  R  RL   
Sbjct: 463  ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522

Query: 265  NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLS 324
             E++        E +  R++ E    R  + LK+ ++ + E+ + ++++ +  EE  D  
Sbjct: 523  EEEERLQQRLRSEQQLRREQEE----RREQLLKREEEKRLEQERREQRLKREQEERRDQL 578

Query: 325  FKLREFASHLQQLQDALNELTEEHSKATQ-EWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
             K RE     Q+L+    E  E+  K  + E LE++ + E+ L     +    EE+ + L
Sbjct: 579  LK-REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE----EERRQQL 633

Query: 384  QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443
                 Q E    QL+    + + + L    + E L+Q    L   + + +   E+ E E+
Sbjct: 634  LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR---LKREHEEERREQELAEEEQ 690

Query: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503
             Q   ++   +    + + QL S     QS + +  + +E   +  +    R   +    
Sbjct: 691  EQARERI---KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE---- 743

Query: 504  TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563
                    + +Q Q++E A  +QQ +E++       Q +E++ +G R ++       +Q+
Sbjct: 744  --------SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG-RQRLSARPPLREQR 794

Query: 564  EQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
            E+QL+  AE+    RQ   Q+     EE+E   R+R    K+L+ LE+E+  +     QQ
Sbjct: 795  ERQLR--AEE----RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848

Query: 624  LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683
            LQ   E  D  Q    Q +R   E  R  +      E  ++ +H   A+ A L+ QLR E
Sbjct: 849  LQ---EEEDGLQED--QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA-LQEQLRKE 902

Query: 684  QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
            QQ   E+E          E+LQ             EE ++R     E Q R   +L+ E 
Sbjct: 903  QQLLQEEE----------EELQR------------EEREKRRRQEQERQYREEEQLQQEE 940

Query: 744  RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR--ELAEAMAAQHTAES 801
              L+ + + +R+  E ER  RK  + +LQQ  E    E    RR  E  +    +   + 
Sbjct: 941  EQLLREEREKRRRQERERQYRK--DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998

Query: 802  ECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR-----------QELQ 850
            E EQL++E    R R E  +Q   +   + QE+   L+EE EK R           +ELQ
Sbjct: 999  EEEQLLREEREKRRRQEWERQYRKK-DELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057

Query: 851  EAKEKVAGIESHSEL--QISRQQNELAELHANLARALQQVQEKEVRAQKLA-----DDLS 903
            + +E++ G E  +    ++ RQ  +  EL     + L++  EK  R ++       ++L 
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117

Query: 904  TLQEKMAATSKEVARLETLVRKAGEQQETASRE--LVKEPARAGDRQPEWLEEQQGRQFC 961
              +E++    +E  R + L R+  E++E    E  L++E       +PE    Q+     
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE-------EPEKRRRQE----- 1165

Query: 962  STQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA 1021
                 L+   RE E++  E E+L     E + Q++E + ++E E+ R  Q+R +   D  
Sbjct: 1166 -----LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR--QKRKQRYRDED 1218

Query: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD----QELAKLRGLEAAQI 1077
                 + + E   +NA+ + +V     +      L + + +D    Q+L  L G +  + 
Sbjct: 1219 QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278

Query: 1078 KELEELRQTVKQL----KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAE--VSK 1131
            +E E  R   +      +EQL ++E         Q EA  R   +  + + LR E    +
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREE---------QKEAKRRDRKSQEEKQLLREEREEKR 1329

Query: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
              Q+  ++  + + L +  E +   R ERD      + + +E+ ++    +  L   +RE
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE 1389

Query: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLI-SSLEEEVSILNRQVLEKEGESKE 1250
               F  + Q     E E + +  R R+  E +  L     + +     +QV  +E E K 
Sbjct: 1390 -RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448

Query: 1251 LKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN 1310
            L+       E+ +K  E  +LLQ E         ER     EE Q LR +   ++   + 
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQ-EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507

Query: 1311 LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370
            LR +   +    EE     +  Q KF Q+EQ L   +      Q    +    + L Q+ 
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567

Query: 1371 QAEQAAAEKRHRE-ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAE 1429
            + +Q + ++R R+  LE+ K          +R Q +  + +   Q++  QE   QQLR E
Sbjct: 1568 EEQQLSRQERDRKFRLEEQK----------VRRQEQERKFMEDEQQLRRQEGQ-QQLRQE 1616

Query: 1430 ---KASYAEQLSMLKKAHGLLAEEN--RGLGERANLGRQFLEVELDQAREKYV------- 1477
               K    EQL   ++   L  +E   + L E   L RQ  E +L   R++         
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676

Query: 1478 -----QELAAVRADAETRLAE------------VQREAQSTARELEVMTAKYEGAKVKVL 1520
                 Q+L     D + R  E            +Q E Q   +ELE    + E  + +  
Sbjct: 1677 QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736

Query: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKV-QQQKLKAVQAQG 1579
            +E+ R QE  +K+  + EQL   + EQ  + +E  +K  + +Q  +  ++Q+L++ ++  
Sbjct: 1737 QEQLRRQERYRKILEE-EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795

Query: 1580 GESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE 1639
               ++E  R + +  +L+ Q    +   E  +LQ+E+ +     ++ +    +EQ  + E
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855

Query: 1640 QLQKENKELRAEAERLGHELQQAGLK----TKEAEQTCRHLTAQVRSLEAQVAHADQQLR 1695
            + ++E +EL  E E+   + ++  L+     ++ ++  RH   QV  +++Q      +L 
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH--RQVGEIKSQEGKGHGRLL 1913

Query: 1696 DLGKFQVATDALKS 1709
            + G  Q A+  ++S
Sbjct: 1914 EPGTHQFASVPVRS 1927



 Score =  251 bits (640), Expect = 7e-66
 Identities = 353/1592 (22%), Positives = 668/1592 (41%), Gaps = 192/1592 (12%)

Query: 217  RRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK 276
            ++L+++  +ER  +     +  E R+    ++ Q+   QQ      L  E+Q     + +
Sbjct: 349  QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408

Query: 277  ELEELRDKNESLTMRLHETLKQCQ-----DLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
              ++LR + +   +R  + L++ Q     + K E+ + ++++ +  EE  D   +  E  
Sbjct: 409  REQQLRREQQ---LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465

Query: 332  SH-----LQQLQDALNE--------LTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEE 378
             H      QQL+    E        L EE  +  QE  E+Q + E+E     + K+  +E
Sbjct: 466  RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR--QE 523

Query: 379  KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
            + E LQ +L + E+ L + Q    +E+ E L    + + L+QE         Q + R ++
Sbjct: 524  EEERLQQRL-RSEQQLRREQ----EERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578

Query: 439  LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ-------ASQA 491
            L+ E  +++ +L  E+    E++ +   +    Q         +EE E+        S+ 
Sbjct: 579  LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638

Query: 492  HGARLTAQVASLTSELTTLNATIQQQDQEL-AGLKQQAKEKQAQLAQTLQQQEQASQGLR 550
               R   Q+     E        +++++ L   LK++ +E++ +     ++QEQA + ++
Sbjct: 639  QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698

Query: 551  HQVE----QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL 606
             ++     QL S    ++ ++     KQE  R+   Q+      E E   +E + A +Q 
Sbjct: 699  SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758

Query: 607  EALEKEKAAKLEILQQQLQVANEARDSAQTSV-TQAQREKAELSRKVEELQACVETARQE 665
            +  E+ +    +   ++       R SA+  +  Q +R+     R+  E +   E   +E
Sbjct: 759  QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818

Query: 666  QHEAQAQVAELELQLRSEQQKATEKERVAQ---EKDQLQEQLQ----------------- 705
            Q   Q +  E ELQ   E+++   +ER  Q   E+D LQE  +                 
Sbjct: 819  QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878

Query: 706  ---------------ALKESLKVTKGSLEEE---------KRRAADALEEQQRCISELKA 741
                           AL+E L+  +  L+EE         ++R     E Q R   +L+ 
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 742  ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR--ELAEAMAAQHTA 799
            E   L+ + + +R+  E ER  RK  + +LQQ  E    E    RR  E  +    +   
Sbjct: 939  EEEQLLREEREKRRRQERERQYRK--DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996

Query: 800  ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR-----------QE 848
            + E EQL++E    R R E  +Q   +   + QE+   L+EE EK R           +E
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYRKK-DELQQEEEQLLREEREKRRLQERERQYREEEE 1055

Query: 849  LQEAKEKVAG--IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQ-----KLADD 901
            LQ+ +E++ G   E+    ++ RQ  +  EL     + L++  EK  R +     +  ++
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115

Query: 902  LSTLQEKMAATSKEVARLETLVRKAGEQQETASRE--LVKEPARAGDRQPEWLEEQQGRQ 959
            L   +E++    +E  R + L R+  E++E    E  L++E       +PE    Q+   
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE-------EPEKRRRQE--- 1165

Query: 960  FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD 1019
                   L+   RE E++  E E+L     E + Q++E + ++E E+ R  Q+R +   D
Sbjct: 1166 -------LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR--QKRKQRYRD 1216

Query: 1020 LALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD----QELAKLRGLEAA 1075
                   + + E   +NA+ + +V     +      L + + +D    Q+L  L G +  
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276

Query: 1076 QIKELEELRQTVKQL----KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR--AEV 1129
            + +E E  R   +      +EQL ++E         Q EA  R   +  + + LR   E 
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREE---------QKEAKRRDRKSQEEKQLLREEREE 1327

Query: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
             +  Q+  ++  + + L +  E +   R ERD      + + +E+ ++    +  L   +
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387

Query: 1190 RELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLI-SSLEEEVSILNRQVLEKEGES 1248
            RE   F  + Q     E E + +  R R+  E +  L     + +     +QV  +E E 
Sbjct: 1388 RE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446

Query: 1249 KELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS 1308
            K L+       E+ +K  E  +LLQ E         ER     EE Q LR +   ++   
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQ-EREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505

Query: 1309 ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ 1368
            + LR +   +    EE     +  Q KF Q+EQ L   +      Q    +    + L Q
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565

Query: 1369 QLQAEQAAAEKRHRE-ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427
            + + +Q + ++R R+  LE+ K          +R Q +  + +   Q++  QE   QQLR
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQK----------VRRQEQERKFMEDEQQLRRQE-GQQQLR 1614

Query: 1428 AEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADA 1487
             E+          ++   LL E       R    R+FLE E    R++  Q+L   R D 
Sbjct: 1615 QERD------RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL---RHDR 1665

Query: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
            + +            RE E +  + E  +++  E  ++F+EE Q+L  Q  + +  Q EQ
Sbjct: 1666 DRKF-----------REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714

Query: 1548 TKQVEELSKKLADSDQ-ASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
              + +EL +K  + +Q   + +Q++L+  +      ++E  R + +  +L+ Q   ++  
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR 1774

Query: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE--LRAEAERLGHELQQAGL 1664
             E      E+ +   + ++ ++QE   + R  EQL++E +E  LR +     +  ++  L
Sbjct: 1775 EE------EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828

Query: 1665 KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRD 1696
            + +E EQ  R    +    E Q A  ++  R+
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRRE 1860



 Score =  240 bits (612), Expect = 1e-62
 Identities = 347/1574 (22%), Positives = 672/1574 (42%), Gaps = 157/1574 (9%)

Query: 221  KQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEE 280
            ++  DE   R    LEL   RK   EK  Q    Q R+ +     E +    +  KE E+
Sbjct: 202  EEFPDEEQLRRRELLEL--RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259

Query: 281  LRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDA 340
            L+++       L E  +Q + L+ ++ + +R+  +  ++      +LR      QQL+  
Sbjct: 260  LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ------RLR----REQQLRRK 309

Query: 341  LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDN 400
              E   E  +  +E  E++ Q E+     L+ ++  EE+ E    +  + E    QL+  
Sbjct: 310  QEEERREQQEERREQQERREQQEERREQQLRREQ--EERREQQLRREQEEERREQQLRRE 367

Query: 401  PPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEE 460
              +E+ E        + L++E         QL+   ++   ++ ++E +L  E+    E+
Sbjct: 368  QEEERRE--------QQLRRE--------QQLRREQQLRREQQLRREQQLRREQQLRREQ 411

Query: 461  KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ-QQDQ 519
            + +    +   Q       + + E +   +    RL  +       L     T + +Q++
Sbjct: 412  QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471

Query: 520  ELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE-ATR 578
                LK+  +E++ +    L+++E+  Q  R + +      +++EQ+LK   E++    R
Sbjct: 472  RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531

Query: 579  QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
                QQL    EER   L +R+   K+LE   +E+  K E  +++ Q+     +  Q  +
Sbjct: 532  LRSEQQLRREQEERREQLLKREEE-KRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590

Query: 639  TQAQREKAELSRKVEELQACVETARQEQH---------------EAQAQVAELELQLRSE 683
             + Q E+ E   K EE++   +  R+EQ                +++ Q    + QLR E
Sbjct: 591  KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650

Query: 684  QQKATEKE-RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE----------EQ 732
            QQ+  E+  +  +E+++L+++L+   E  +  +   EEE+ +A + ++          E 
Sbjct: 651  QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710

Query: 733  QRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAH-QAETEVLRRELAE 791
            +    + K  +R   ++ +R R+E EE+R  R+  E + Q+   AH Q + E  RR+   
Sbjct: 711  EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES-ELQWQEEERAHRQQQEEEQRRDFTW 769

Query: 792  AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE 851
               A+  +E   ++L        +R    + EE Q     +++ +  +EE E+ R++ +E
Sbjct: 770  QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ---QREQRFLPEEEEKEQRRRQRRE 826

Query: 852  AKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRA-QKLADDLSTLQEKMA 910
             ++++  +E   +LQ   +  +L E    L    ++ + +E R  QK    L   +++  
Sbjct: 827  REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886

Query: 911  ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970
             T      L+  +RK  +  +    EL +E      RQ +  + ++  Q    +  L   
Sbjct: 887  HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946

Query: 971  EREAEQ---------------------MGNELERLRAALMESQGQQQEERGQQEREVARL 1009
            ERE  +                     +G E E+ R    E + +++EE  Q+E ++ R 
Sbjct: 947  EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006

Query: 1010 TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE--------- 1060
             +E+ R Q +   +   + EL+   +  L E+R E   LQE       E+E         
Sbjct: 1007 EREKRRRQ-EWERQYRKKDELQQEEEQLLREER-EKRRLQERERQYREEEELQQEEEQLL 1064

Query: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQ-LKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
            G+++E  + + LE    KE EEL+Q  +Q L+E+  K+ ++       + E   + E   
Sbjct: 1065 GEERETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123

Query: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSL----------EAERASRAERDSALE---T 1166
             + E  +    +LE+Q ++++E     E+ L          E ER  R E +   E    
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD-HSKAEDEWKAQ----------VAR 1215
            L+ + E++ QE           QR+    R + +D  S  + +W+ +            +
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243

Query: 1216 GRQEAERKNSLISSLEEEVSILNRQVL--EKEGESKELKRLVMAESEKSQKLEERL-RLL 1272
            GR+  + +    S L +  S  + Q L  E++   +E +R    + ++    EE+L R  
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303

Query: 1273 QAETASNSARAAERSSALREEVQS--LREEAEKQRVASENLRQELTSQAERAEELGQELK 1330
            Q E      ++ E    LREE +    R+E +++    E L QE   Q  R +E  ++ K
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE--RDRK 1361

Query: 1331 AWQEKFFQKEQALSTLQLE-HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
              +E+   +EQ    L+ E     Q    + L  +   +  + EQ   + R R+  E+ +
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421

Query: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAE 1449
            Q +   R E  R  RE        Q+V  QER  + L  E+    E+    ++   LL E
Sbjct: 1422 QLS---RQERDRKFRE------EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472

Query: 1450 ENRGLGERANLGRQFLEVELD---QAREKYVQELAAVRADAETRLAEVQREAQSTARELE 1506
                   R    R+FLE E     Q R++  +E      + E +  E +++     R+ +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532

Query: 1507 VMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASK 1566
             +    E  +++  E  Q+ +++R +   + EQL   + EQ    +E  +K    +Q  +
Sbjct: 1533 FL---QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589

Query: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
             Q+Q+ K +     E +Q+ +R + Q  +L+ +  +K +  E    + E+ + H   + +
Sbjct: 1590 RQEQERKFM-----EDEQQLRRQEGQ-QQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643

Query: 1627 QNQELQEQLRSLE---QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR-- 1681
            +  E + QLR  E   QL+ +      E E+L  E ++  L+ +E ++  R    Q+R  
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703

Query: 1682 SLEAQVAHADQQLR 1695
              E +    +QQLR
Sbjct: 1704 ERERKFLQEEQQLR 1717



 Score =  233 bits (595), Expect = 1e-60
 Identities = 316/1376 (22%), Positives = 600/1376 (43%), Gaps = 142/1376 (10%)

Query: 357  EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL- 415
            EK+A+ + + S  LQD++  EE     + +  QLEE   Q +    QE+   L +  +  
Sbjct: 98   EKRARCDGKESL-LQDRR-QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155

Query: 416  ---ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH----FEEEKQQLSSLI 468
               E L+Q            Q +      ER  +E +L + +GH    F +E+Q     +
Sbjct: 156  EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215

Query: 469  TDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQA 528
             +L+       + +EE +Q  +    R+  +      E       +++++++L       
Sbjct: 216  LELRR------KGREEKQQQRRERQDRVFQEEEE--KEWRKRETVLRKEEEKL------- 260

Query: 529  KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
            +E++ Q  + LQ++E+  + L  Q  +L    +++EQQ + +  +Q+  R+         
Sbjct: 261  QEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQQQRLRREQQLRRKQE------- 311

Query: 589  AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
             EER     ER    ++ E  E+ +       +QQL+   E R   Q    Q +  + + 
Sbjct: 312  -EERREQQEERREQQERREQQEERR-------EQQLRREQEERREQQLRREQEEERREQQ 363

Query: 649  SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE----KERVAQEKDQLQEQL 704
             R+ +E +   +  R+EQ   + Q    E QLR EQQ   E    +E+  + + QL+ + 
Sbjct: 364  LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423

Query: 705  QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER-----KELEE 759
            Q  +E  +       E++RR      EQ+     LK E  +  E+H++ER     K  +E
Sbjct: 424  QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET--ERHEQERRKQQLKRDQE 481

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
            E    + L+   ++  E  +   + LRRE  E    +   + E E+L + + + ++   +
Sbjct: 482  EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541

Query: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ-ISRQQNELAE-- 876
             ++   Q     +E+ +  +   ++ ++E +E ++++   E     Q + R+Q E  E  
Sbjct: 542  QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601

Query: 877  LHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRE 936
            L       L+Q + +E R ++   +    Q+ + +  +E  R + L R   EQQE   + 
Sbjct: 602  LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR---EQQERREQR 658

Query: 937  LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ-Q 995
            L +E       + E LE++  R+    +   +  E E EQ     ER+++ + + Q Q +
Sbjct: 659  LKRE------EEEERLEQRLKREHEEERREQELAEEEQEQ---ARERIKSRIPKWQWQLE 709

Query: 996  QEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHA 1055
             E   +Q +  +R  ++ G+ +     EK  R E E++ Q    E+R      +E     
Sbjct: 710  SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ---EEERAHRQQQEEEQRRD 766

Query: 1056 LT----EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
             T     +E  ++   +L      + +   +LR   +Q +EQ    E+E       Q   
Sbjct: 767  FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 1112 AGRTEPTGPKLEALRAEVS-KLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
              +      +L+ L  E   +  ++ Q+ QE+ D L+   E  R+    RD   +  + Q
Sbjct: 827  REK------ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD---QKWRWQ 877

Query: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSL 1230
            LEE+ +   H+  A  + Q +L   +  +Q+  + E + + +  R RQE ER+      L
Sbjct: 878  LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-ELQREEREKRRRQEQERQYREEEQL 936

Query: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA---AERS 1287
            ++E   L R+  E+E   ++ +     + +K Q+ EE+L   + E      R     E  
Sbjct: 937  QQEEEQLLRE--EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994

Query: 1288 SALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ 1347
               +EE Q LREE EK+R      RQE   Q  + +EL QE    +E+  ++E+     +
Sbjct: 995  ELQQEEEQLLREEREKRR------RQEWERQYRKKDELQQE----EEQLLREER--EKRR 1042

Query: 1348 LEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG 1407
            L+    Q    E L  +   +QL  E+   E R R+ELE+  +       EL + + +L 
Sbjct: 1043 LQERERQYREEEELQQEE--EQLLGEE--RETRRRQELERQYRK----EEELQQEEEQLL 1094

Query: 1408 ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV 1467
               P +++  E+ER   Q R E+    E+  +L+        E R    R  L RQ+ E 
Sbjct: 1095 REEPEKRRRQERER---QCREEEELQQEEEQLLR--------EEREKRRRQELERQYREE 1143

Query: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
            E  Q  E+ +     +R + E R    ++E +   RE E +  + E     + EE+++ +
Sbjct: 1144 EEVQQEEEQL-----LREEPEKRR---RQELERQYREEEELQQEEEQL---LREEQEKRR 1192

Query: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
            +ER++   + E+L+  +R+Q  + E+    L    +  K    +   V  +G E++Q  Q
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252

Query: 1588 RLQAQLNELQAQL-------SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
               +QL + Q+Q         Q+E+  E  + + ++   H+  ++Q  +E Q++ +  ++
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312

Query: 1641 LQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ-VRSLEAQVAHADQQLR 1695
              +E K+L  E        Q+   K +E EQ  +    Q +R  E      +++LR
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368



 Score =  214 bits (546), Expect = 5e-55
 Identities = 313/1431 (21%), Positives = 597/1431 (41%), Gaps = 176/1431 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
            L+  + + +RLK++  +E   +  L+ E  E R+    +  Q    +QR+ R        
Sbjct: 610  LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-------- 661

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
                      EE  ++ E    R HE  ++ Q+L  E+ +  R+  ++        ++L 
Sbjct: 662  ----------EEEEERLEQRLKREHEEERREQELAEEEQEQARE--RIKSRIPKWQWQL- 708

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS 388
            E  +  +Q +       +E  +  QE  EK+ + E EL    +++   +++ E       
Sbjct: 709  ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE------E 762

Query: 389  QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEA 448
            Q  +   Q Q     E+G         + L            QL+A       ER Q+E 
Sbjct: 763  QRRDFTWQWQAEEKSERGR--------QRLSARPPLREQRERQLRAE------ERQQREQ 808

Query: 449  KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT 508
            + L E    EEEK+Q      + +  +  L + +E+L++  +A   +L  +   L  +  
Sbjct: 809  RFLPE----EEEKEQRRRQRREREKELQFLEE-EEQLQRRERAQ--QLQEEEDGLQEDQE 861

Query: 509  TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
               +  Q++DQ+    + Q +E++ +   TL  +    + LR + + L    ++ +++ +
Sbjct: 862  RRRSQEQRRDQK---WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918

Query: 569  EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL---- 624
            E   +QE  RQ + ++     EE +    ER+   +Q    +  K  KL+  ++QL    
Sbjct: 919  EKRRRQEQERQ-YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977

Query: 625  --QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
              +   + R+       + Q+E+ +L R+  E +   E  RQ + + + Q  E +L LR 
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL-LRE 1036

Query: 683  EQQK--ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
            E++K    E+ER  +E+++LQ++ + L           EE + R    LE Q R   EL+
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLG---------EERETRRRQELERQYRKEEELQ 1087

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
             E   L+ +   +R+  E ER  R+  E + ++     +   +  R+EL      +   +
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147

Query: 801  SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
             E EQL++E    R R E  +Q   +   + QE+   L+EE EK RQE    +E+    E
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREE-EELQQEEEQLLREEQEKRRQE----RERQYREE 1202

Query: 861  SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKL------ADDLSTLQEKMAATSK 914
               + Q  +Q+    +  ++L    +  +E  VR  K+       +    L++      +
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262

Query: 915  EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREA 974
                L+ L+   GEQQE   R+  +E  R   R   + EE+Q             +ERE 
Sbjct: 1263 SQQDLQHLL---GEQQE---RDREQERRRWQQRDRHFPEEEQ-------------LERE- 1302

Query: 975  EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
                   E+  A   + + Q++++  ++ERE  R  QE  R   +       R E  +R 
Sbjct: 1303 -------EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355

Query: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
            Q    + R E    QE     L E++   ++  + + L+  Q    +E  Q ++Q +++ 
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154
             ++E++  S    + +   R E                EQQ ++Q+ +     + LE E+
Sbjct: 1416 FREEEQQLSRQ--ERDRKFREE----------------EQQVRRQERE----RKFLEEEQ 1453

Query: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214
              R ER       +  L+E+ ++  H Q        E    R + +D    E E ++   
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS--- 1510

Query: 1215 RGRQEAERKNSLISSLEEEVSI----LNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
               QE ERK      LEEE  +      R+ L++E + +  +R      ++ +K  E  +
Sbjct: 1511 ---QEPERK-----FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562

Query: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRV-----------ASENLRQELTSQA 1319
            L Q       +R  ER    R E Q +R + ++++              + LRQE   + 
Sbjct: 1563 LRQEREEQQLSR-QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621

Query: 1320 ERAEELGQELKAWQ-------EKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372
               E+L QE +  Q        KF ++E  L   + E         +    + L Q+ + 
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 1373 EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKAS 1432
            +Q   ++R R+  E+ +Q     R      + +      L +K  E+E+  Q+   E+  
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741

Query: 1433 YAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE-LDQAREKYVQELAAVRADAETRL 1491
              E+   + +   L  E       R    R+F E E L Q RE+  Q+L +  +D + R 
Sbjct: 1742 RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE--QQLRSQESDRKFRE 1799

Query: 1492 AE---VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQT 1548
             E    +RE Q    +      ++E  ++++ E+ QR ++ER +     EQ    Q +  
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT-QEKSR 1858

Query: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
            ++ +EL +     ++  K +Q++ + ++ +    QQ+ ++   Q+ E+++Q
Sbjct: 1859 REEQELWQ-----EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904



 Score =  192 bits (488), Expect = 3e-48
 Identities = 296/1187 (24%), Positives = 521/1187 (43%), Gaps = 152/1187 (12%)

Query: 606  LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
            LE L+ +   +++  +  L +   A+ +   ++ QA     E   + +  ++ ++  RQE
Sbjct: 58   LELLDLDSNGRVDFNEFLLFIFKVAQ-ACYYALGQATGLDEEKRARCDGKESLLQDRRQE 116

Query: 666  QHEAQAQVAELELQLRSEQ---QKATEKERVAQEKDQLQEQLQALKESLKVTKGS----- 717
            + + + +  + +L+    Q   QK  E+ER   E ++  E+ + L++  +  +       
Sbjct: 117  EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQ 176

Query: 718  ----LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
                 E E+RRA +  E+ Q C      ET    ++ +  R+EL E R  RKG E + QQ
Sbjct: 177  RQEWQEREERRAEE--EQLQSCKGH---ETEEFPDEEQLRRRELLELR--RKGREEKQQQ 229

Query: 774  LGE----AHQAETE--------VLRRE----LAEAMAAQHTAESECEQLVKEVAAWRERY 817
              E      Q E E        VLR+E      E    Q   + E EQL K     +E  
Sbjct: 230  RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK--LERQELR 287

Query: 818  EDSQQEEAQYGAMFQEQLMTLKEECEKARQ--ELQEAKEKVAGIESHSELQISRQQNELA 875
             + Q+EE Q   + +EQ +  K+E E+  Q  E +E +E+    E   E Q+ R+Q E  
Sbjct: 288  RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347

Query: 876  EL-------HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK--- 925
            E             + L++ QE+E R Q+L  +    +E+     +++ R + L R+   
Sbjct: 348  EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407

Query: 926  ------AGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGN 979
                    EQQ    ++L +E       Q    E ++ R     +     ++RE E   +
Sbjct: 408  RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467

Query: 980  ELERLRAALMESQGQQQEERG-QQEREVARLTQER-----GRAQADLALEKAARAELEMR 1033
            E ER +  L   Q +++ ER  + E E  R  QER      R Q +   ++  R E E R
Sbjct: 468  EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527

Query: 1034 LQNALNEQRVEFATLQEALAHALTEKEGK--DQELAKLRGLEAAQIKELEELRQTVKQLK 1091
            LQ  L  ++      +E     L  +E K  +QE  + R L+  Q +  ++L +  ++ +
Sbjct: 528  LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR-LKREQEERRDQLLKREEERR 586

Query: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE--QQCQKQQEQAD----S 1145
            +Q  K+E+E       + E   R E    + + L+ E  + E  QQ  K +EQ +     
Sbjct: 587  QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 1146 LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV------ 1199
            L R  +  R  R +R+   E L+ +L+ + +E    Q  LA  ++E A  R K       
Sbjct: 647  LRREQQERREQRLKREEEEERLEQRLKREHEEERREQE-LAEEEQEQARERIKSRIPKWQ 705

Query: 1200 -QDHSKAEDEW--------KAQVARGRQEAE----RKNSLISSLEEEVSILNRQVLEKEG 1246
             Q  S+A+           K +  R RQE E    R+ S +   EEE +  +RQ  E+E 
Sbjct: 706  WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA--HRQQQEEE- 762

Query: 1247 ESKELKRLVMAESEKSQKLEERL--RLLQAETASNSARAAERSSALR-------EEVQSL 1297
            + ++      AE EKS++  +RL  R    E      RA ER    +       E+ Q  
Sbjct: 763  QRRDFTWQWQAE-EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQE---LKAWQEKFFQKEQALS---TLQLEHT 1351
            R+  E+++       +E   + ERA++L +E   L+  QE+   +EQ        QLE  
Sbjct: 822  RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881

Query: 1352 STQ---ALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408
              +    L ++    + L ++ Q  Q   E+  REE E+ +      R E  R  RE  +
Sbjct: 882  RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR------RQEQERQYREEEQ 935

Query: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAE--ENRGLGERANLGRQFLE 1466
            L    +++  +ER  ++ +  +  Y +   + +K   LL E  E R   ER    R+  E
Sbjct: 936  LQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE--E 993

Query: 1467 VELDQAREKYVQELAAVRADAE-----TRLAEVQREAQSTARELEVMTAKYEGAKVKVLE 1521
             EL Q  E+ ++E    R   E      +  E+Q+E +   R         E  + + L+
Sbjct: 994  EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR---------EEREKRRLQ 1044

Query: 1522 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581
            ER+R   E ++L  + EQL   +RE T++ +EL ++    ++  + ++Q L+    +   
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERE-TRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103

Query: 1582 SQQEAQ-RLQAQLNELQAQLSQKE-----------QAAEHYKLQMEKAK-THYDAKKQQN 1628
             ++E Q R + +L + + QL ++E           Q  E  ++Q E+ +    + +K++ 
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163

Query: 1629 QELQEQLRSLEQLQKENKE-LRAEAERLGHELQQAGLKTKEAEQTCR 1674
            QEL+ Q R  E+LQ+E ++ LR E E+   E ++   + +E ++  R
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210



 Score =  139 bits (350), Expect = 3e-32
 Identities = 194/799 (24%), Positives = 343/799 (42%), Gaps = 77/799 (9%)

Query: 948  QPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ-EERGQQEREV 1006
            Q   L+E++  +    ++ LQ   +E +Q     E     L E  GQ++ ++R +QERE+
Sbjct: 91   QATGLDEEKRARCDGKESLLQDRRQEEDQ--RRFEPRDRQLEEEPGQRRRQKRQEQEREL 148

Query: 1007 ARLTQERGRAQADLALEKAARAEL--EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
            A      G  Q+    EK  R E     R    L  QR E+   +E  A     +  K  
Sbjct: 149  A-----EGEEQS----EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH 199

Query: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
            E  +    E  + +EL ELR+  ++ K+Q  ++ ++       + E   R      + E 
Sbjct: 200  ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259

Query: 1125 LRAEVSKLEQQCQKQQEQADSLER-SLEAERASRAERDSALETLQGQLEEKAQELGHSQS 1183
            L+ E  + +++ Q+++EQ   LER  L  ER    ++   L   Q QL  K +E      
Sbjct: 260  LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLRRKQEE------ 312

Query: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN-RQVL 1242
                 +RE    R + Q+  + ++E + Q  R  QE  R+  L    EEE      R+  
Sbjct: 313  ----ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368

Query: 1243 EKEGESKELKRLVMAESEKSQKLEERLR---LLQAETASNSARAAERSSALREEVQSLRE 1299
            E+E   ++L+R      E+  + E++LR    L+ E      +   R   LR E Q  RE
Sbjct: 369  EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428

Query: 1300 EAE---KQRVASENLRQEL-TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
            + E   +Q+   E   Q L   Q ER + L +E +  + +  +++Q L   Q E    + 
Sbjct: 429  QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 1356 LVSELLPAKHLC----QQLQAEQAAAEKRHREELEQSKQAAGGLRAE--LLRAQRELGEL 1409
            L  E    +       QQL+ EQ    ++  +  E+ ++    LR+E  L R Q E  E 
Sbjct: 489  LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 1410 IPLR--QKVAEQERTAQQLRAEKASYAEQL---SMLKKAHGLLAEENRGLGERANLGRQF 1464
            +  R  +K  EQER  Q+L+ E+    +QL      ++   L  E+   L +R  L R+ 
Sbjct: 549  LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR--LKRE- 605

Query: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV-LEER 1523
             EVE  +  E+  Q L     + E R   ++ E Q   R+ ++   + E  + ++  EE 
Sbjct: 606  -EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 1524 QRFQEERQKLTAQVE--QLEVFQREQTKQVEELSKKL----------ADSDQASKVQQQK 1571
            +   E+R K   + E  + E+ + EQ +  E +  ++          AD+ Q+    + +
Sbjct: 665  EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 1572 LKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKL----------QMEKAKTHY 1621
             +  Q +  E +++ +R +++L   + + + ++Q  E  +           + E+ +   
Sbjct: 725  KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784

Query: 1622 DAKKQQNQELQEQLRSLEQLQKENKELRAEAE-----RLGHELQQAGLKTKEAEQTCRHL 1676
             A+    ++ + QLR+ E+ Q+E + L  E E     R   E ++     +E EQ  R  
Sbjct: 785  SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 1677 TAQVRSLEAQVAHADQQLR 1695
             AQ    E      DQ+ R
Sbjct: 845  RAQQLQEEEDGLQEDQERR 863



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 83/364 (22%), Positives = 160/364 (43%), Gaps = 31/364 (8%)

Query: 1371 QAEQAAAEKRHREELEQSKQAAGGL-------RAELLRAQRELGELIPLRQKVAEQERTA 1423
            Q E+   ++R ++  EQ ++ A G        R E    QR   EL   RQ+  E+E   
Sbjct: 128  QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187

Query: 1424 ---QQLRAEKASYAEQL---SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1477
               +QL++ K    E+      L++   LL    +G  E+    R+  +    +  EK  
Sbjct: 188  AEEEQLQSCKGHETEEFPDEEQLRRRE-LLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246

Query: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537
            ++   V    E +L E + + Q   +E E    K E         RQ  + ERQ+   Q 
Sbjct: 247  RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE---------RQELRRERQEEEQQQ 297

Query: 1538 EQLEVFQREQTKQVEELSKKLAD--SDQASKVQQQKLKAVQAQGGESQQEAQRL-QAQLN 1594
            ++L   Q+ + KQ EE  ++  +    Q  + QQ++ +  Q +  + ++  Q+L + Q  
Sbjct: 298  QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357

Query: 1595 ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAER 1654
            E + Q  ++EQ  E  + Q+ + +     +++Q    ++QLR  +QL++E +  R +  R
Sbjct: 358  ERREQQLRREQEEERREQQLRREQ---QLRREQQLRREQQLRREQQLRREQQLRREQQLR 414

Query: 1655 LGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQA 1714
               +L++     +E E+       +    E ++    ++ RD  K +  T+  +  + + 
Sbjct: 415  REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE--RHEQERR 472

Query: 1715 KPQL 1718
            K QL
Sbjct: 473  KQQL 476



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 78/341 (22%), Positives = 152/341 (44%), Gaps = 45/341 (13%)

Query: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
            L++ K+A    +  LL+ +R+  +      +  + E    Q R +K    E+    + A 
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER----ELAE 150

Query: 1445 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1504
            G    E +   E+ +  RQ  + EL + R+++ QE    RA+ E   +    E +    E
Sbjct: 151  GEEQSEKQERLEQRD--RQRRDEELWRQRQEW-QEREERRAEEEQLQSCKGHETEEFPDE 207

Query: 1505 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQT---KQVEELSKKLADS 1561
             ++   +    + K  EE+Q+ + ERQ    Q E+ + +++ +T   K+ E+L ++    
Sbjct: 208  EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267

Query: 1562 DQASKVQQQKLKAVQAQG--GESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
             +  + ++++L+ ++ Q    E Q+E Q+ Q    E Q +  Q+E+  E    Q E+ + 
Sbjct: 268  QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE----QQEERRE 323

Query: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1679
              + ++QQ +  ++QLR  EQ ++  ++LR E E    E Q   L+ ++ E+        
Sbjct: 324  QQERREQQEERREQQLRR-EQEERREQQLRREQEEERREQQ---LRREQEEER------- 372

Query: 1680 VRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDL 1720
                  Q    +QQLR              RE Q + +  L
Sbjct: 373  ----REQQLRREQQLR--------------REQQLRREQQL 395


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  255 bits (652), Expect = 3e-67
 Identities = 387/1557 (24%), Positives = 646/1557 (41%), Gaps = 226/1557 (14%)

Query: 237  LAENRKLLTEKDAQIAMMQQRI----DRLALLNEKQAASPLEPKELEE----LRDKNESL 288
            LA     L ++  Q+  M+ R     D L  L ++ + S  E + LEE    LRDK +  
Sbjct: 521  LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDG- 579

Query: 289  TMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEH 348
             M+ HE  +             R++ +L   N  LS +    A  LQ  Q    EL +E 
Sbjct: 580  AMQAHEDAQ-------------REVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER 626

Query: 349  SK--ATQEWLEKQA-QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405
             K  A QE L +Q  +LE+E   A+QD   +  + E    +L QLE   S L     + +
Sbjct: 627  EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686

Query: 406  GEVLGDVLQLETLKQEAATLAANNTQLQA---RVEMLETERGQQEA-------KLLAERG 455
              +    LQ + L+ E A +A   T+ +A    +E+  T+   +EA       KL A   
Sbjct: 687  EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746

Query: 456  HFEEEKQQLSSLITDLQSSISNLS----QAKEEL----EQASQAHGARLTAQVA--SLTS 505
               ++K  L+ L+  L+   S L     QA++E     E+  +    RL  +VA   L  
Sbjct: 747  SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806

Query: 506  ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL-------QQQEQASQGLRHQVEQLSS 558
             L       +  +Q+L  L+ +  + Q QLAQ         Q+ EQA +  + QVE L  
Sbjct: 807  SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 866

Query: 559  SLKQKEQQLKE---------VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA- 608
            + ++KE   KE          AE++  T  + A +L    E  E SL E    L QLEA 
Sbjct: 867  AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR 926

Query: 609  ---LEKEKAA----------KLEILQQQLQVANEA----RDSAQTSVTQAQRE-----KA 646
               LE E  A          +L  L+QQ+    E     ++     + QA+RE     + 
Sbjct: 927  REQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLRE 986

Query: 647  ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706
            + +   E+LQ           E +A+ A+L+ QL+ EQ++     R+  EK++L E++ A
Sbjct: 987  QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA--RLEAEKEELSEEIAA 1044

Query: 707  LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG 766
            L++         E EK++A    E ++  +SE    TR     H      LE ER  R  
Sbjct: 1045 LQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTR-----HSLATISLEMERQKRDA 1099

Query: 767  LEARLQQLGEAHQAETEVLR--RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 824
             ++R +Q      A T  LR  R   E  AA H  E    + ++E A    +  DS   E
Sbjct: 1100 -QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEV---RRLQEQARDLGKQRDSCLRE 1155

Query: 825  AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ------ISRQQNELAELH 878
            A+     + QL  L++  +  R+EL EA+ K+   +   E+Q      + R   E A+  
Sbjct: 1156 AEE---LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKER 1212

Query: 879  ANLARALQQVQEKEVRAQ------KLADD-----LSTLQEKMAATSKEVARLETLVRKAG 927
              L R+ ++++    +A+      KLA++     L+ L+E   A  KE   L T +++  
Sbjct: 1213 EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVE 1272

Query: 928  EQQETASRELVKEPARAGDRQPEWLEEQQ---GRQFCSTQAALQAMEREAEQMGNELERL 984
              +  A REL +       RQ + L+ +    GR+    Q  L   ER  ++   E   L
Sbjct: 1273 RSRLEARRELQELR-----RQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGL 1327

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERG----RAQADLALEKAARAELEMRLQNA--- 1037
            R  L++ +   +  R + +    +L ++ G    R +  L   + AR   + +L +A   
Sbjct: 1328 RQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGL 1387

Query: 1038 ---LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ----- 1089
               L   R E A L   L+ A    +G + ELA++     A   +L  LR  +++     
Sbjct: 1388 ELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLG 1447

Query: 1090 ---------LKEQLAKKEKEHASGSGAQSEAA-------------GRTEPTGPKL--EAL 1125
                     +    A+      SG G  S +                T P  P L  EA+
Sbjct: 1448 RAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAV 1507

Query: 1126 RAEVSKLEQQCQKQQEQADSLERSLEAERAS----RAERDSALET---LQGQLEEKAQEL 1178
            R  + +  Q+ +  Q + D L     A         AERDSA      LQ  + E  +  
Sbjct: 1508 RGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEAR 1567

Query: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238
                  L+  Q ELA     V+   +       QVA   +  +   S + + +E++S + 
Sbjct: 1568 RSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627

Query: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS---ALREEVQ 1295
                + EG+ + LK ++ A   ++ KLE + R L+ E   +    ++R +   AL++ V 
Sbjct: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687

Query: 1296 SLREEAEKQRVASENLR---QELTSQAERAEE----LGQELKAWQEKFFQKEQALSTLQL 1348
            SL+ +     V +  L+   + L     + EE    L  +++   E   Q   +L++ + 
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747

Query: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408
            ++   Q     L   +H  Q LQ    AA +   E  +QS     G + + LR     GE
Sbjct: 1748 KNLHLQ---KALTACEHDRQVLQERLDAARQALSEARKQSSSL--GEQVQTLR-----GE 1797

Query: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468
            +  L  +  E E   QQLR       E  +        L +E R L ER           
Sbjct: 1798 VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG--------- 1848

Query: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
               + ++ + +L A + + E     ++++  +  R L+    K E  K++  E+  R   
Sbjct: 1849 ---SLQRALAQLEAEKREVERSALRLEKDRVALRRTLD----KVEREKLRSHEDTVRLSA 1901

Query: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588
            E+ +L   +   E+   E  +Q+++L  ++   +Q+    Q ++ A Q Q  E QQE +R
Sbjct: 1902 EKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVER 1960

Query: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE-QLQKE 1644
            L++     QAQ  +  +A E              A +Q+ + L+EQ+ +L+ QLQ+E
Sbjct: 1961 LRS----AQAQTERTLEARER-------------AHRQRVRGLEEQVSTLKGQLQQE 2000



 Score =  237 bits (605), Expect = 8e-62
 Identities = 434/1902 (22%), Positives = 783/1902 (41%), Gaps = 269/1902 (14%)

Query: 247  KDAQIAMMQQRIDRLALLNEKQAASPL-----EPKELEELRDKNESLTMRLHETLKQCQD 301
            +DAQI  +   I  +   N  Q  SP+     E   L  L+++N+ L   L         
Sbjct: 40   QDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQ 99

Query: 302  LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
             + E+ ++  K N +SE    L   LR     L+  +     L  +  +  ++  E+QA 
Sbjct: 100  SRAERDELAIKYNAVSER---LEQALRLEPGELETQEP--RGLVRQSVELRRQLQEEQAS 154

Query: 362  LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
              ++L A  + ++   +  + LQGK+ Q ++  S+L+    +  GE          L+Q+
Sbjct: 155  YRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGE----------LEQQ 204

Query: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS----LITDLQSSISN 477
                  ++  L++ +  LE E+ Q+ A L        E+  Q  S    L  D++   ++
Sbjct: 205  RLRDTEHSQDLESALIRLEEEQ-QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTND 263

Query: 478  LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE----KQA 533
             ++ ++ELE    A      +  A  ++E + L    +Q    + G ++   E     + 
Sbjct: 264  WTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQ----VVGFRRLVSEVKMFTER 319

Query: 534  QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
             L Q   +  + S+ ++     LS+ L+  E + +   EKQ   +    +QL      R+
Sbjct: 320  DLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL------RD 373

Query: 594  ASLRERDAALKQLEA-LEK----EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
              LRE+D A +Q+++ L+K     +  +L +  ++L+  N  +D     +T  ++ +A  
Sbjct: 374  KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLT--EKLEALE 431

Query: 649  SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL- 707
            S +++E QA +ET  ++    Q  + +L   + S+ +   +     +  D     L+ L 
Sbjct: 432  SLRLQE-QAALET--EDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLS 488

Query: 708  -----KESLKVTKGSLEEEKRRAA-------------DALEEQQRCISELKAETRSLVEQ 749
                     + + G     +R  +              AL ++Q  + +++    +  + 
Sbjct: 489  GQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDL 548

Query: 750  HKRERKELEEERAGRKGLEARLQQLG-------EAHQ----------AETEVLRRELAEA 792
                RK+L +  + R+ LE +LQ+L        +AH+          +  E+L RE +  
Sbjct: 549  LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL 608

Query: 793  MAAQHTAESECEQL----------VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK--- 839
              +   A+ + E+L           +E+   R+R E+ Q++  Q GA  + +L       
Sbjct: 609  AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668

Query: 840  EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA----------LQQVQ 889
            E+ E  R  L +   +V    S + LQ    Q E AE+   L +A          + +++
Sbjct: 669  EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728

Query: 890  EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQP 949
             +E   Q     LS L E +A    ++ RL   + +     +   R+  +E   A + Q 
Sbjct: 729  AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ- 787

Query: 950  EWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVA-- 1007
            E LEE +  Q  + Q  L+   R AEQ    LE+    L   + Q QE+  Q  R+++  
Sbjct: 788  ERLEELRLEQEVARQ-GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR 846

Query: 1008 --RLTQERGRAQADL-ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
               L Q R  AQ  + ALE+AAR       + AL +   E A L   L  A  E     +
Sbjct: 847  EQELEQARREAQRQVEALERAARE------KEALAK---EHAGLAVQLVAAEREGRTLSE 897

Query: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
            E  +LR        E E L  ++ +++ QLA+ E         Q EA G+        E 
Sbjct: 898  EATRLR-------LEKEALEGSLFEVQRQLAQLEARR-----EQLEAEGQALLLAK--ET 943

Query: 1125 LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA 1184
            L  E++ L QQ    QE+A SL++ L A++  +AER+ A  +L+ Q     ++L   Q  
Sbjct: 944  LTGELAGLRQQIIATQEKA-SLDKELMAQKLVQAERE-AQASLREQRAAHEEDLQRLQRE 1001

Query: 1185 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 1244
              +A REL A R ++Q   + E E        R EAE++      L EE++ L ++    
Sbjct: 1002 KEAAWRELEAERAQLQSQLQREQE----ELLARLEAEKE-----ELSEEIAALQQE--RD 1050

Query: 1245 EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ 1304
            EG       L++AESEK Q L  +         S     +E+    R  + ++  E E+Q
Sbjct: 1051 EG-------LLLAESEKQQALSLK--------ESEKTALSEKLMGTRHSLATISLEMERQ 1095

Query: 1305 RVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAK 1364
            +  +++ +++  S         ++L+A      Q+E+A +    E    Q    +L   +
Sbjct: 1096 KRDAQSRQEQDRSTVNALTSELRDLRA------QREEAAAAHAQEVRRLQEQARDLGKQR 1149

Query: 1365 HLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
              C + +AE+       R +L   + A  GLR ELL AQR+L E    R+    Q + A 
Sbjct: 1150 DSCLR-EAEEL------RTQLRLLEDARDGLRRELLEAQRKLRESQEGRE---VQRQEAG 1199

Query: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
            +LR      A++   L++++    EE R   ++A   R    + L  A E   Q+LA + 
Sbjct: 1200 ELRRSLGEGAKEREALRRSN----EELRSAVKKAESER----ISLKLANEDKEQKLALLE 1251

Query: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ 1544
             +A T + +   E ++  +E+E                R   + E Q+L  Q++ L+   
Sbjct: 1252 -EARTAVGKEAGELRTGLQEVE--------------RSRLEARRELQELRRQMKMLDSEN 1296

Query: 1545 REQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKE 1604
                +++ EL  +LA  ++A K              ES++E   L+ +L + +A L    
Sbjct: 1297 TRLGRELAELQGRLALGERAEK--------------ESRRETLGLRQRLLKGEASLEVMR 1342

Query: 1605 QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK---ELRAEAERLGHELQQ 1661
            Q  +  + ++++ +  +  ++++     E+ R  E+ Q ++    EL+ EA R   E  +
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARA--EAAE 1400

Query: 1662 AGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLS 1721
             GL+   AE   + L A++  +E Q   A+ QL  L +  +       R P   P+    
Sbjct: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL-RSALRRGLGLGRAPSPAPRPVPG 1459

Query: 1722 IDSLDLSCE-EGTPLSITSKL---PRTQPDGTSVPGEPASPISQRLPPKV---ESLESLY 1774
              + D   E  G  L+  S L   P +QP     PG   SP S  L P+       E L 
Sbjct: 1460 SPARDAPAEGSGEGLNSPSTLECSPGSQPPS---PGPATSPASPDLDPEAVRGALREFLQ 1516

Query: 1775 FTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSS 1834
                  R +  L +   +L     +   +  SA  R  Q+       +  V E + A  S
Sbjct: 1517 ELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL-------QKAVAESEEARRS 1569

Query: 1835 FYSTRSAPASQASLRATSSTQS-LARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSS 1893
                 S   ++ +L+  S  +S   R  + D     + +L      T S  R SQ  +S 
Sbjct: 1570 VDGRLSGVQAELALQEESVRRSERERRATLD----QVATLERSLQATESELRASQEKISK 1625

Query: 1894 GAPPGRNSFYMGTCQDEPEQLD-DWNRIAELQQRNRVCPPHLK-----------TCYPLE 1941
                   +   G  +   E LD   +R  +L+ + R     L+               L+
Sbjct: 1626 --MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ 1683

Query: 1942 SRPSLSLGTITDEEMKTGDPQETLRR--ASMQPIQIAEGT------GITTRQQRKRVSLE 1993
             R       + D E+K G  Q T+ R   ++  ++ +EG       G+T    +   SL 
Sbjct: 1684 DRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLN 1743

Query: 1994 PHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAA 2035
              +       K  T+C       ++R +  +Q+ +EA+K+++
Sbjct: 1744 STRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785



 Score =  232 bits (591), Expect = 3e-60
 Identities = 360/1593 (22%), Positives = 677/1593 (42%), Gaps = 196/1593 (12%)

Query: 237  LAENRKLLTEKD-----AQIAMMQQRIDRLAL-------LNEKQAASPLEPKEL------ 278
            L    K+ TE+D      ++A   + +    L       L E +A + LE + L      
Sbjct: 309  LVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLE 368

Query: 279  EELRDK---NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
            E+LRDK    + L  +  ++     DL    +++   + +L ++N +     ++    L+
Sbjct: 369  EQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLE 428

Query: 336  QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC---LEEKNEILQGKLSQLEE 392
             L+     L E+ +  T++    Q  L     A L D +    L             L  
Sbjct: 429  ALESL--RLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG 486

Query: 393  HLSQLQDNPPQEKGEVLGDVLQL--ETLKQEAATLAANNTQLQARVEMLETERGQQEAK- 449
               Q   +PP+      G   +        +++TLA  ++ L  R   ++  RG+ EA  
Sbjct: 487  LSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQ 546

Query: 450  -----LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504
                 L  +    E E++ L   +  L+       QA E+ ++  Q    RL +    L+
Sbjct: 547  DLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ----RLRSANELLS 602

Query: 505  SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564
             E + L  ++Q   Q+   L+Q+ ++ QA   +  +Q+++  +     V+  +   ++ E
Sbjct: 603  REKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662

Query: 565  QQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624
            +  +++ E+ E  R   A++L    E REA  R    A  Q + L+ EKA   E L +  
Sbjct: 663  RSHRQL-EQLEGKRSVLAKELV---EVREALSR----ATLQRDMLQAEKAEVAEALTK-- 712

Query: 625  QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ---LR 681
              A   R   + S+T+ + E+A L   + +L A  E+  Q++ +    VA+LE +   L+
Sbjct: 713  --AEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ 770

Query: 682  SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
              Q++A ++  VA+E+   QE+L+ L+   +V +  LE   R A  A E  ++ +  L+ 
Sbjct: 771  GRQRQAEQEATVAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827

Query: 742  ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL--AEAMAAQHTA 799
            E   L EQ  +  ++L        G E  L+Q     Q + E L R     EA+A +H  
Sbjct: 828  ERSQLQEQLAQLSRQL-------SGREQELEQARREAQRQVEALERAAREKEALAKEHAG 880

Query: 800  ESECEQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQ-----EQLMTLKEECEKARQ 847
             +     V+ VAA RE    S+       ++EA  G++F+      QL   +E+ E   Q
Sbjct: 881  LA-----VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935

Query: 848  ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907
             L  AKE + G     EL   RQQ    +  A+L + L  + +K V+A++ A   ++L+E
Sbjct: 936  ALLLAKETLTG-----ELAGLRQQIIATQEKASLDKEL--MAQKLVQAEREAQ--ASLRE 986

Query: 908  KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967
            + AA  +++ RL+        ++E A REL  E A+        L+ Q  R+    +  L
Sbjct: 987  QRAAHEEDLQRLQ-------REKEAAWRELEAERAQ--------LQSQLQRE---QEELL 1028

Query: 968  QAMEREAEQMGNELERLR----AALMESQGQQQEERGQQEREVARLTQE-----RGRAQA 1018
              +E E E++  E+  L+      L+ ++ ++Q+    +E E   L+++        A  
Sbjct: 1029 ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI 1088

Query: 1019 DLALEK-----AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE 1073
             L +E+      +R E +    NAL  +  +    +E  A A  ++  + QE A+  G +
Sbjct: 1089 SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148

Query: 1074 A-AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
              + ++E EELR  ++ L++      +E         EA  +   +    E  R E  +L
Sbjct: 1149 RDSCLREAEELRTQLRLLEDARDGLRRE-------LLEAQRKLRESQEGREVQRQEAGEL 1201

Query: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192
             +   +  ++ ++L RS E  R++  + +S   +L+   E+K Q+L   + A  +  +E 
Sbjct: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261

Query: 1193 AAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
               RT +Q+  ++  E + ++   R++ +  +S  + L  E++ L  ++   E   KE +
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR 1321

Query: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL---REEA---EKQRV 1306
            R  +   ++  K E  L +++ E      +  E+    R   + L    EEA   EKQ++
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381

Query: 1307 -ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL----- 1360
              +  L  +L +    A ELG  L A + +    E  L+ ++++  + +A +  L     
Sbjct: 1382 DHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALR 1441

Query: 1361 ---------LPAKHLCQQLQAEQAAAE-----KRHREELEQS------------------ 1388
                      PA        A  A AE           LE S                  
Sbjct: 1442 RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPD 1501

Query: 1389 ---KQAAGGLR---AELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
               +   G LR    EL  AQRE  E   LR + +   R   ++ AE+ S   +   L+K
Sbjct: 1502 LDPEAVRGALREFLQELRSAQRERDE---LRTQTSALNRQLAEMEAERDSATSRARQLQK 1558

Query: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502
            A     E  R +  R +  +  L ++ +  R    +  A +      ++A ++R  Q+T 
Sbjct: 1559 AVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATL-----DQVATLERSLQATE 1613

Query: 1503 REL---EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
             EL   +   +K +  + K+  +++R +E      ++  +LE+ +R    +++     L+
Sbjct: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673

Query: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
            D +  ++  Q ++ ++Q Q  +S+ +A  LQ  +  L   L++ E++    +   +K + 
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR---DKVRG 1730

Query: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1679
              +A  Q +  L         LQK       + + L   L  A     EA +    L  Q
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQ 1790

Query: 1680 VRSLEAQVAHAD-QQLRDLGKFQVATDALKSRE 1711
            V++L  +VA  + Q++   G+ Q   + L+ R+
Sbjct: 1791 VQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823



 Score =  143 bits (361), Expect = 2e-33
 Identities = 282/1268 (22%), Positives = 512/1268 (40%), Gaps = 194/1268 (15%)

Query: 48   EGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHST 107
            EG   + +   E L+     L+  R      E L    + L G E EL +          
Sbjct: 805  EGSLRVAEQAQEALEQQLPTLRHERSQLQ--EQLAQLSRQLSGREQELEQARREAQRQVE 862

Query: 108  MSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENF-LQKAPVPSTCSSTFPE 166
               ++ R+ E    K  A LAV L  V    +G  L+E+     L+K            E
Sbjct: 863  ALERAAREKEALA-KEHAGLAVQL--VAAEREGRTLSEEATRLRLEK------------E 907

Query: 167  ELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADE 226
             L     + +R++  LE ++    + G   L            +T   ++  L++Q+   
Sbjct: 908  ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK---------ETLTGELAGLRQQIIAT 958

Query: 227  RSNRDELELELAENRKLLTEKDAQIAMMQQRI----DRLALLNEKQAASPLEPKELEELR 282
            +  +  L+ EL   + +  E++AQ ++ +QR     D   L  EK+AA     +ELE  R
Sbjct: 959  QE-KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW----RELEAER 1013

Query: 283  DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGD---LSFKLREFASHLQQLQ- 338
             + +S   R  E L     L+ EK ++  +I  L +E  +   L+   ++ A  L++ + 
Sbjct: 1014 AQLQSQLQREQEEL--LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071

Query: 339  DALNE--LTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE---- 392
             AL+E  +   HS AT   LE + Q     S   QD+  +      L+   +Q EE    
Sbjct: 1072 TALSEKLMGTRHSLATIS-LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAA 1130

Query: 393  HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
            H  +++    QE+   LG   Q ++  +EA  L      L+   + L  E  + + KL  
Sbjct: 1131 HAQEVR--RLQEQARDLGK--QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186

Query: 453  ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512
             +   E ++Q+      +L+ S+   ++ +E L ++++     L + V    SE  +L  
Sbjct: 1187 SQEGREVQRQEAG----ELRRSLGEGAKEREALRRSNE----ELRSAVKKAESERISLKL 1238

Query: 513  TIQQQDQELAGLKQ--QAKEKQA-QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
              + ++Q+LA L++   A  K+A +L   LQ+ E++    R ++++L   +K  + +   
Sbjct: 1239 ANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1298

Query: 570  VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
            +  +    +   A       E R  +L  R   LK          A LE+++Q+LQVA  
Sbjct: 1299 LGRELAELQGRLALGERAEKESRRETLGLRQRLLK--------GEASLEVMRQELQVAQR 1350

Query: 630  ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE--------------AQAQVAE 675
                      + Q ++ E   +   L   +E AR  + +              A+A+ AE
Sbjct: 1351 ----------KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400

Query: 676  LELQLRSEQQKA----TEKERVAQEKDQLQEQLQALKESLKVTKG--------------- 716
            L L+L + + +A     E  RV  ++   + QL  L+ +L+   G               
Sbjct: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460

Query: 717  -SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG 775
             + +     + + L           ++  S          +L+ E A R  L   LQ+L 
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPE-AVRGALREFLQELR 1519

Query: 776  EAH------QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE--RYEDSQQEEAQY 827
             A       + +T  L R+LAE  A + +A S   QL K VA   E  R  D +    Q 
Sbjct: 1520 SAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQA 1579

Query: 828  GAMFQE---------------QLMTLKEECEKARQELQEAKEKVAGIESH---------- 862
                QE               Q+ TL+   +    EL+ ++EK++ ++++          
Sbjct: 1580 ELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRR 1639

Query: 863  -------SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 915
                   SE +  + + +   L   L R+   + ++E +AQ L D + +LQ ++A +  +
Sbjct: 1640 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVK 1699

Query: 916  VARLETLVRKAG------EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQA 969
               L+  V +        E+ E A R+ V+    A  +    L   + +     Q AL A
Sbjct: 1700 AGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNL-HLQKALTA 1758

Query: 970  MEREAEQMGNELERLRAALMESQGQQQEERGQQER----EVARLTQERGRAQADLAL--- 1022
             E + + +   L+  R AL E++ +Q    G+Q +    EVA L  +R  A+  L     
Sbjct: 1759 CEHDRQVLQERLDAARQALSEAR-KQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817

Query: 1023 -------EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAA 1075
                    +AA      +LQ+     +    +LQ ALA    EK   ++   +L     A
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877

Query: 1076 QIKELEELRQTVKQLKEQL----AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
              + L+++ +   +  E      A+K +   + +GA+ E A        +++ L A+V  
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQR----QIQQLEAQVVV 1933

Query: 1132 LEQQCQKQQEQADSLERSLEAE------RASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
            LEQ     Q + D+ ++ LE +      R+++A+ +  LE  +    ++ + L    S L
Sbjct: 1934 LEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL 1993

Query: 1186 -ASAQREL 1192
                Q+EL
Sbjct: 1994 KGQLQQEL 2001



 Score =  141 bits (355), Expect = 8e-33
 Identities = 214/969 (22%), Positives = 385/969 (39%), Gaps = 134/969 (13%)

Query: 215  QMRRLKKQLADERSNRDELELELAENR-KLLTEKDAQIAMMQQRIDRLALLNEKQAASPL 273
            ++RRL++Q  D    RD    E  E R +L   +DA+  + ++ ++    L E Q    +
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193

Query: 274  EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASH 333
            + +E  ELR         L E  K+ + L+    ++   + +   E   L     +    
Sbjct: 1194 QRQEAGELRRS-------LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246

Query: 334  LQQLQDALNELTEEHSK---ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL 390
            L  L++A   + +E  +     QE    + +  +EL    +  K L+ +N  L  +L++L
Sbjct: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306

Query: 391  EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL 450
            +  L+  +    + + E LG  L+   LK EA+            +E++  E    + KL
Sbjct: 1307 QGRLALGERAEKESRRETLG--LRQRLLKGEAS------------LEVMRQELQVAQRKL 1352

Query: 451  LAERGHFEEEKQQLSSLITDLQSSISNLSQAK-EELEQASQAHGARLT-----AQVASLT 504
              + G F   +++L          + +L +A+  E +Q   A G  L      A+ A L 
Sbjct: 1353 QEQEGEFRTRERRL----------LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402

Query: 505  SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564
              L+      Q  + ELA ++ Q +  +AQL   L+   +   GL          +    
Sbjct: 1403 LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRSALRRGLGLGRAPSPAPRPVPGSP 1461

Query: 565  QQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624
             +        E        + +  ++          A+   L+  E  + A  E LQ+ L
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPAS-PDLDP-EAVRGALREFLQE-L 1518

Query: 625  QVANEARDSAQTSVTQAQREKAEL-------SRKVEELQACVETARQEQHEAQAQVA--E 675
            + A   RD  +T  +   R+ AE+       + +  +LQ  V  + + +     +++  +
Sbjct: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQ 1578

Query: 676  LELQLRSEQQKATEKERVA--QEKDQLQEQLQALKESL----------KVTKGSLEEEKR 723
             EL L+ E  + +E+ER A   +   L+  LQA +  L          K  +  LE +KR
Sbjct: 1579 AELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKR 1638

Query: 724  RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
            R  + L+  +    +L+ + RSL  + +R R  L +  A  + L+ R+  L +   A++E
Sbjct: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSL-QRQVADSE 1697

Query: 784  VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQE------QLMT 837
            V    L   +   + A ++ E+      A R++     +  AQ  A           L  
Sbjct: 1698 VKAGTLQLTVERLNGALAKVEE---SEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754

Query: 838  LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897
                CE  RQ LQE  +      S +  Q S    ++  L   +A    Q  E E + Q+
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814

Query: 898  LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG 957
            L + L   QE  AA    V +L+              R L++E  R G  Q         
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQD------------ERRLLQE--RLGSLQ--------- 1851

Query: 958  RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017
                   A L+A +RE E+    LE+ R AL  +  + + E+ +   +  RL+ E+GR  
Sbjct: 1852 ----RALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLD 1907

Query: 1018 ADLALEKAARAELEM-RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
              L       AELE+   Q  + +   +   L+++ + A  E + + Q+      LE  Q
Sbjct: 1908 RTL-----TGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ------LELQQ 1956

Query: 1077 IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136
              E+E LR    Q +  L  +E+ H                   ++  L  +VS L+ Q 
Sbjct: 1957 --EVERLRSAQAQTERTLEARERAHRQ-----------------RVRGLEEQVSTLKGQL 1997

Query: 1137 QKQQEQADS 1145
            Q++  ++ +
Sbjct: 1998 QQELRRSSA 2006



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 106/442 (23%), Positives = 191/442 (43%), Gaps = 75/442 (16%)

Query: 217  RRLKKQLADERSNRDELEL-------ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQA 269
            RRLK+ L    S   +LEL       EL  +R  L++++AQ   +Q R+D L    ++Q 
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSL----QRQV 1693

Query: 270  ASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLRE 329
            A         E++     LT+                 +++  + ++ E  G L  K+R 
Sbjct: 1694 AD-------SEVKAGTLQLTV----------------ERLNGALAKVEESEGALRDKVRG 1730

Query: 330  FASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQ 389
                L Q   +LN              +K   L+K L+A   D++ L+E+ +  +  LS+
Sbjct: 1731 LTEALAQSSASLNSTR-----------DKNLHLQKALTACEHDRQVLQERLDAARQALSE 1779

Query: 390  LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAK 449
              +  S L +     +GEV    L+L+ ++ E         QLQ   E+L  +R + EA 
Sbjct: 1780 ARKQSSSLGEQVQTLRGEVAD--LELQRVEAEG--------QLQQLREVLR-QRQEGEAA 1828

Query: 450  LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTT 509
             L      ++E++ L   +  LQ +++ L   K E+E+++     RL     +L   L  
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSA----LRLEKDRVALRRTLDK 1884

Query: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ---- 565
            +     +  ++   L  +    + +L +TL   E      + Q++QL + +   EQ    
Sbjct: 1885 VEREKLRSHEDTVRLSAE----KGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSP 1940

Query: 566  -QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ-LEALEKEKAAKLEILQQQ 623
             QL+  A++Q+   Q   ++L +A  + E +L  R+ A +Q +  LE++ +     LQQ+
Sbjct: 1941 AQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000

Query: 624  LQVANEARDSAQTSVTQAQREK 645
            L+     R SA  S      EK
Sbjct: 2001 LR-----RSSAPFSPPSGPPEK 2017


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  241 bits (615), Expect = 5e-63
 Identities = 377/1839 (20%), Positives = 777/1839 (42%), Gaps = 235/1839 (12%)

Query: 12   LSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKN 71
            L  +  LH+A+  + + QL+D    I+ +++  G    +   K+ + E L+     + + 
Sbjct: 330  LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE--TKRQMHETLEMKEEEIAQL 387

Query: 72   RKHPSSPECLVSAQKVLEGSEL--ELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAV 129
            R            Q   +G EL  +  K           +  + +  E+   K++AE+  
Sbjct: 388  RSR--------IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439

Query: 130  ILKFV--LDHEDGLNLNEDLENFLQKAPVPSTCSS---------TFPEELSPPSHQ---- 174
             +K +     E+ ++L ++L    Q+       SS            +EL+    +    
Sbjct: 440  QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499

Query: 175  -AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRD-E 232
               RE  F E  KVA   S + +L  S      + L   + ++++       E   RD +
Sbjct: 500  LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559

Query: 233  LELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRL 292
             E E    R L  E   + ++ + +     L    +A      KE+  + +K+++     
Sbjct: 560  QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL--- 616

Query: 293  HETLKQCQD-LKTEKSQMDR--------KINQLSEENGDLSFKLRE--FASHLQQLQDAL 341
             E+LK  QD L TEK Q+ +        K+ +  E+  +   K +E  F +H+++    +
Sbjct: 617  -ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE----M 671

Query: 342  NELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNP 401
            NE T E     Q  LE    L  ELS  L+ +  LEE+  +L+ +  ++++ L    D  
Sbjct: 672  NEKTLEKLDVKQTELE---SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728

Query: 402  PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG-HFEEE 460
                 + +  +     +K+   ++      L+ ++  LE         LL ER  H +E 
Sbjct: 729  KNHHQQQVDSI-----IKEHEVSIQRTEKALKDQINQLEL--------LLKERDKHLKEH 775

Query: 461  KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520
            +  + +L  D++ S   L QA  +L+   Q++ +    Q  +   +L  L   +   + E
Sbjct: 776  QAHVENLEADIKRSEGELQQASAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834

Query: 521  LAGLKQQAKEKQAQ---LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE-KQEA 576
               L +Q  E +AQ   +   L   +   Q L  Q+E+ +S ++QK + L +V E K E 
Sbjct: 835  RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894

Query: 577  TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
              ++  Q      E+    L+ R+   K++E L ++ +AK    +  + + NE     +T
Sbjct: 895  GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK----EDSIHILNE---EYET 947

Query: 637  SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
                 +++  ++ +K +E+Q   ET +++  +   Q A+L+ +L +   + ++KE+  Q 
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQ---ETLKKKLLD---QEAKLKKELENTALELSQKEK--QF 999

Query: 697  KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE-QQRCISELKAETRSLVEQHKRERK 755
              ++ E  QA    +      LE  ++   ++L E  +R ++++ +     + Q   E +
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059

Query: 756  ELEEERAGRKGLE-ARLQQLGEAHQAETEVLRRE---LAEAMAAQHTAESECEQLVKE-- 809
            E+ E +   K  E A L+Q       E E + +E   L E    Q T  +E ++ +K+  
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119

Query: 810  ------------VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
                        + A  E+ E    +  +     QEQL+ LK   E+ ++++ E   K+ 
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179

Query: 858  GIE--------SHSE---------LQISRQQNELA---ELHANLARALQQVQEKE---VR 894
              +        SH +         L+  +   ELA   ++      AL + +  E   + 
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239

Query: 895  AQKLADDLSTLQEKMAATSK----------EVARLETLVRKAGEQQETASRELVKEPARA 944
            + K    LS +      T+K           V+ LE  +R+  E+Q T +          
Sbjct: 1240 SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF------- 1292

Query: 945  GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG---QQQEERGQ 1001
              +Q     E++  Q  S +A ++++  E E +  E    + A  E +    Q ++E  +
Sbjct: 1293 --QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350

Query: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQN--ALNEQRVEFATLQEALAHALTEK 1059
                V  + +E    + +++       +L ++LQN  +L+E+    ++L++       E 
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410

Query: 1060 EGKDQELA-KLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT 1118
              + Q+L+ K+  L   +I  LE++     +  E   K +           E   + E  
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470

Query: 1119 GPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178
              +      +++ L+++  +Q ++ D L+  +E +++   +++S LET   +L+ +   +
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET---ELKSQTARI 1527

Query: 1179 GHSQSALASAQRELAAFRTKVQDHSKAED----EWKAQVARGRQEAERKNSLISSLEEEV 1234
               +  +     E+ +    ++++++ +D    E   ++   ++  E K++ +   EE++
Sbjct: 1528 MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI 1587

Query: 1235 SILNRQV----LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA----RAAER 1286
              L  QV     E E + KEL+ + ++   K ++L+     L++E+A+  A    +A ++
Sbjct: 1588 LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQK 1647

Query: 1287 SSALREEVQSLREEAEKQ-RVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345
             +A+++++ S  EE E+Q +  +E+   EL ++ +  E   +E+   +EK    E + S 
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE---REVHILEEKLKSVESSQSE 1704

Query: 1346 LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE 1405
              +   S + +      A +  Q+    Q   +K + E++                 QR 
Sbjct: 1705 TLIVPRSAKNV------AAYTEQEEADSQGCVQKTYEEKISV--------------LQRN 1744

Query: 1406 LGELIPLRQKVA-EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQF 1464
            L E   L Q+V  E+E T       +  Y E+L  L+ A     E+   +G         
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH-------- 1796

Query: 1465 LEVELDQAREKY--------VQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK 1516
            L+ EL++  +KY         +E       A+  L  V  + Q T +E E +T +    K
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE-LTCQILEQK 1855

Query: 1517 VKVLE-----ERQRFQEERQKLTAQVEQLEVFQR--EQTKQVEELSKKLADSDQASKVQQ 1569
            +K L+     +++  + E ++LT++ E+L+  Q+   + K  E L +   +  ++  VQ 
Sbjct: 1856 IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQP 1915

Query: 1570 QKLKAVQAQGGE-------SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYD 1622
            + L  ++AQ  +       +++E Q+L  ++  LQ  L       + ++ ++E  K  YD
Sbjct: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL---RMLRKEHQQELEILKKEYD 1972

Query: 1623 AKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS 1682
              +++ ++++++   LE   K N  L+        +L Q   K +E E T +    + + 
Sbjct: 1973 --QEREEKIKQEQEDLE--LKHNSTLKQLMREFNTQLAQ---KEQELEMTIKETINKAQE 2025

Query: 1683 LEAQV--AHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
            +EA++  +H ++  + L K     D LK    + +  LD
Sbjct: 2026 VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILD 2064



 Score =  224 bits (570), Expect = 9e-58
 Identities = 314/1536 (20%), Positives = 659/1536 (42%), Gaps = 171/1536 (11%)

Query: 306  KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365
            K Q+ +++ ++         K  E  +  Q LQ    +L    S++  + L + A+L +E
Sbjct: 136  KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195

Query: 366  LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK------ 419
            L    Q KK L+E+       L + ++++S LQ      K  +    + ++ LK      
Sbjct: 196  LQMDQQAKKHLQEE---FDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLE 252

Query: 420  -------------QEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS 466
                          +   +  + T ++  +E L+    +QE  L   +   +  K+Q + 
Sbjct: 253  PQAEVFTKEENPESDGEPVVEDGTSVKT-LETLQQRVKRQENLLKRCKETIQSHKEQCTL 311

Query: 467  LITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ 526
            L ++ ++    L +  +ELE+    H A  T     L ++L      I+Q +Q+   +  
Sbjct: 312  LTSEKEALQEQLDERLQELEKIKDLHMAEKT----KLITQLRDAKNLIEQLEQDKGMVIA 367

Query: 527  QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 586
            + K    Q+ +TL+ +E+    LR +++Q+++    + ++L+E  EK E    +  ++  
Sbjct: 368  ETKR---QMHETLEMKEEEIAQLRSRIKQMTT----QGEELREQKEKSERAAFEELEKAL 420

Query: 587  TAAEEREASLRERDAAL-KQLEALEKEKAAKLEILQQQL-----QVANEARDSAQTSVTQ 640
            + A++ E + R+  A + +Q++ +EK    +   LQQ+L     +V +  + S++  + +
Sbjct: 421  STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK 480

Query: 641  AQR-EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
             Q+  + EL+RK +EL   ++T  +E  E      ++++ L   Q   +E  +++QEK+Q
Sbjct: 481  LQKLHEKELARKEQELTKKLQTREREFQE------QMKVALEKSQ---SEYLKISQEKEQ 531

Query: 700  LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
             QE L AL+E     K  L E + +  D  +E +         TR ++E      K L+E
Sbjct: 532  -QESL-ALEELELQKKAILTESENKLRDLQQEAETY------RTR-ILELESSLEKSLQE 582

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
             +   K L   L+     H  E  V        M  +H  E E  +  ++ A W E+ + 
Sbjct: 583  NKNQSKDLAVHLEAEKNKHNKEITV--------MVEKHKTELESLKHQQD-ALWTEKLQV 633

Query: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV--AGIESHSELQISR---QQNEL 874
             +Q+       +Q ++  L+E+CE+ ++ L + KE +  A IE  +E  + +   +Q EL
Sbjct: 634  LKQQ-------YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL 686

Query: 875  AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
              L + L+  L+   + E     L D    +++++ A   E          +  ++   S
Sbjct: 687  ESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS 746

Query: 935  RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ 994
             +  ++  +    Q E L +++ +     QA ++ +E + ++   EL++  A L   Q  
Sbjct: 747  IQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSY 806

Query: 995  QQ---EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA 1051
            Q    E+    E ++A+L Q+    + +  L     AE+E + ++   E       +Q+ 
Sbjct: 807  QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866

Query: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS-GSGAQSE 1110
            +     EK+  + E  K++ L      +LE+  +  +Q K+ L +KE        G + E
Sbjct: 867  MQQL--EKQNSEME-QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923

Query: 1111 AAGRTEPTGPKLEAL-----------RAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
                T+    K +++           + +  K+E+  QK +E  ++L++ L  + A   +
Sbjct: 924  IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983

Query: 1160 R--DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE--------- 1208
               ++ALE  Q + +  A+ L  +Q+  A     ++   T  ++  ++  E         
Sbjct: 984  ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV 1043

Query: 1209 ---WKAQVARGRQEAERKNSL-ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK 1264
               W+ ++ +  +E +  + + +   E+EV+ L +++L    E +E+ + +    E+  K
Sbjct: 1044 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103

Query: 1265 LEERLRLLQAETASNSARA---AERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
             +  L  LQ +    SA     A+  + L+  ++ L  +  K    +  L+++L      
Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163

Query: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHT-STQALVSELLPAKHLCQQLQAE------- 1373
            AEE  +++     K    ++   +L+  H  S ++L  + L  K L ++L  +       
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223

Query: 1374 -QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE----LIPLRQKVAEQERTAQQLRA 1428
             +A  E +  E +  S      + + +   Q    +    L+     V+E E   +QL  
Sbjct: 1224 TEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE 1283

Query: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488
            E+ +    +S  +  H L  +EN+    +A++     E E  Q      Q+ A+ +    
Sbjct: 1284 EQNTL--NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI 1341

Query: 1489 TRLA------------------EVQREAQSTARELEVMTAKYEGA------KVKVLEERQ 1524
            T+L                   E + E  S +++L  +  + + +      +  +   R+
Sbjct: 1342 TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRK 1401

Query: 1525 RFQEERQKLTAQVEQL----EVFQREQT---KQVEELSKKLADSDQASKVQ----QQKLK 1573
            ++ EE+ +L  QV+ L    +   +E+    +QV++ S K ++  + ++ +    Q  +K
Sbjct: 1402 QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461

Query: 1574 AVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ-NQELQ 1632
             +Q Q     +EA     Q+N L+ +L Q+ +  +  K +ME  K+  + K+     EL+
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELK 1521

Query: 1633 EQLRSLEQLQKENKELRAEAERLGHEL----QQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
             Q   + +L+    +   E E L   L    QQ  ++ KE  Q  +H        + +V 
Sbjct: 1522 SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK 1581

Query: 1689 HADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDS 1724
             A++++  L     +  A    + +    ++LS+ S
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617



 Score =  221 bits (562), Expect = 8e-57
 Identities = 400/1809 (22%), Positives = 766/1809 (42%), Gaps = 298/1809 (16%)

Query: 40   IDRIHGTEEGQQI-LKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKM 98
            I  I  T E ++I L+Q +S     V   ++K     SS E +   QK+    E ELA+ 
Sbjct: 441  IKTIEKTSEEERISLQQELSRVKQEVVDVMKK-----SSEEQIAKLQKL---HEKELARK 492

Query: 99   TMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLN-EDLENFLQKAPVP 157
               L     + ++     EQ +  ++   +  LK   + E   +L  E+LE  LQK  + 
Sbjct: 493  EQELT--KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE--LQKKAIL 548

Query: 158  STCSSTFPEELSPPSHQAKR-EIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQM 216
            +   +    +L     +A+    R LEL+     S   N       +   D+    + + 
Sbjct: 549  TESEN----KLRDLQQEAETYRTRILELESSLEKSLQEN------KNQSKDLAVHLEAEK 598

Query: 217  RRLKKQLADE-RSNRDELELELAENRKLLTEKDAQIAMMQQ-RIDRLALLNEKQAASPLE 274
             +  K++      ++ ELE    +   L TEK   +    Q  +++L    E++  + L+
Sbjct: 599  NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658

Query: 275  PKEL------EELRDKN-----------ESLTMRLHETLKQCQDLKTEKSQMDRKINQLS 317
             KE+      EE+ +K            ESL+  L E LK    L+ E S +  + +++ 
Sbjct: 659  DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718

Query: 318  EENGDLSFKLREFASHLQQ-------------------LQDALNELT------EEHSKAT 352
            +E   L  K+ E  +H QQ                   L+D +N+L       ++H K  
Sbjct: 719  QE---LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775

Query: 353  QEWLE------KQAQLEKELSAALQD-----KKCLEEKNEILQGKLSQLEEHLSQLQDNP 401
            Q  +E      K+++ E + ++A  D     +    E+ +  + +L+QL++ L  L+   
Sbjct: 776  QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET-- 833

Query: 402  PQEKGEVLGDVLQLETLKQEAAT-LAANNTQLQARVEMLETERGQQEAKLLAERGHFE-- 458
              E+  +   V ++E  K++  T L A+  Q+Q  ++ LE +  + E K+ +    +E  
Sbjct: 834  --ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891

Query: 459  -----EEKQQLSSLITDLQSSISNLSQA-KEELEQASQAHGARLTAQVASLTSELTTLNA 512
                 +E++Q   ++ + ++ I  + +  K+E+E  +Q    +L+A+  S+         
Sbjct: 892  LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ----KLSAKEDSIHILNEEYET 947

Query: 513  TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK---- 568
              + Q++++  +KQ+AKE Q  L + L  QE     L+ ++E  +  L QKE+Q      
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKML 1004

Query: 569  EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL-QVA 627
            E+A+   A   D   +L T  +E+  SL E            +E    + I +++L Q A
Sbjct: 1005 EMAQANSAGISDAVSRLETNQKEQIESLTE---------VHRRELNDVISIWEKKLNQQA 1055

Query: 628  NEARDSAQTSVTQAQREKAELSRKV-------EELQACVETARQEQHEAQAQVAELELQL 680
             E ++  +  + + ++E AEL +K+       EE+   +   ++E  +    + EL+ QL
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGS---LEEEKRRAADALEEQQRCIS 737
            +   QK+     +AQ++ +L+  L+ L+  L  +      L+E+        EE +R +S
Sbjct: 1116 K---QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172

Query: 738  ELKA-------ETRSLVEQHKRERKELEEERAGRKGL-------------------EARL 771
            EL +       E +SL   H++  K LE++    K L                   EA+ 
Sbjct: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKT 1232

Query: 772  QQLGEAHQAETEVLRRELA----------EAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
             +L     ++T  +   ++          EA+  +    SE E  ++++   +     S 
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF 1292

Query: 822  QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE----SHSELQISRQQNELAEL 877
            Q+        + Q+ ++K + E    E +EA +K  G +    S  E  I++ + EL+E 
Sbjct: 1293 QQATHQLEEKENQIKSMKADIESLVTE-KEALQKEGGNQQQAASEKESCITQLKKELSEN 1351

Query: 878  HANLARALQQVQEKEVRAQKLADDLS----------TLQEKMAATS-------KEVARLE 920
               +    ++++EK+V    L+  L+          +L EK AA S       +E   L 
Sbjct: 1352 INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411

Query: 921  TLVRKAGEQQETASRELVKEPARAGD---RQPEWLEEQQGR--QFCST----QAALQAME 971
              V+    + +T S+E +    +  D   +  EW ++ Q R  Q  +T    Q  L+   
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471

Query: 972  REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELE 1031
            +EA +   ++  L+  L +   +    +G+ E + +++ ++    + +L  + A   ELE
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531

Query: 1032 MRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL-EELRQTVKQL 1090
                + + ++ +E  +L E L +   +K+ + +EL +    +    +EL EE    VK+ 
Sbjct: 1532 ----DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ----KLQHFQELGEEKDNRVKEA 1583

Query: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL 1150
            +E++   E +  S            E    +LE +   V   E++ +  +++ +S   + 
Sbjct: 1584 EEKILTLENQVYS-------MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636

Query: 1151 EAERASRAERDSAL--ETLQGQLEEKAQE--------LGHSQSALASAQRELAAFRTKVQ 1200
             AE   +AE+  A   + L  Q+EEK ++        L    + L   +RE+     K++
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696

Query: 1201 DHSKAEDEW--------KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE------G 1246
                ++ E                ++EA+ +  +  + EE++S+L R + EKE      G
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756

Query: 1247 ESKELKRLVMAESEKSQKLEERL-RLLQAETASNSARAAERSSALREEVQSLREEAEK-- 1303
            + KE    V +  E   + +ERL +L  AE     A+  E  S +    + L E+ +K  
Sbjct: 1757 QEKE--ETVSSHFEMRCQYQERLIKLEHAE-----AKQHEDQSMIGHLQEELEEKNKKYS 1809

Query: 1304 ----QRVASENLRQELTSQAERAEELGQELKAWQEKFF------QKEQALSTLQLEHTST 1353
                Q V  E  +  + ++           K  QEK        QK + L +  +     
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869

Query: 1354 QALVSELLPAKHLCQQLQA-EQAAAEKRHREELEQS---KQAAGGLRAELLRAQRELGEL 1409
              +  E L +K+  ++LQA +Q     +  E LE++   K  +  ++ +LL       + 
Sbjct: 1870 HRVEMEELTSKY--EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNME--AQH 1925

Query: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG-----LLAEENRGLGERANLGRQF 1464
              L  K+A  ER  Q+L  E     + L ML+K H      L  E ++   E+    ++ 
Sbjct: 1926 NDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED 1985

Query: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ 1524
            LE++ +   ++ ++E     A  E  L    +E  + A+E+E    +    +   L ++ 
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045

Query: 1525 RFQEERQKLTAQ--VEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGES 1582
              +++  K TA+   E L+  + E T +V +L  +L   ++  K  QQKL+  +  G ++
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQL---EELQKKYQQKLEQEENPGNDN 2102

Query: 1583 QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE-QL 1641
                      + ELQ QL+QK       KL              + QE +EQ+ +LE +L
Sbjct: 2103 --------VTIMELQTQLAQKTTLISDSKL--------------KEQEFREQIHNLEDRL 2140

Query: 1642 QKENKELRA 1650
            +K  K + A
Sbjct: 2141 KKYEKNVYA 2149



 Score =  164 bits (416), Expect = 7e-40
 Identities = 256/1316 (19%), Positives = 560/1316 (42%), Gaps = 157/1316 (11%)

Query: 413  LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ 472
            LQ      +A++ ++  T++++R      +    E     E G  +   Q+L   +  ++
Sbjct: 16   LQQALAPAQASSNSSTPTRMRSRTSSFTEQL--DEGTPNRESGDTQSFAQKLQLRVPSVE 73

Query: 473  SSISNLSQAKEELEQASQAHGARLTAQVASLTS-ELTTLNAT------IQQQDQELAGLK 525
            S     S  KE L ++S       T+   SL   +L +  A+      +  + ++L G  
Sbjct: 74   SLFR--SPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNS 131

Query: 526  QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQL 585
                ++Q  L Q L++ E++    R +  +L ++ +  +++ K++      ++    +++
Sbjct: 132  DSLNKEQ--LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI 189

Query: 586  ATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645
            A   EE +   + +    ++ +A  +EK   + +LQ Q+ +  +   +   +V       
Sbjct: 190  AELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNV------- 242

Query: 646  AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQ 705
             ++ + + +L            E QA+V   E    S+ +   E     +  + LQ++++
Sbjct: 243  -DVLKPLPQL------------EPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVK 289

Query: 706  ALKESLKVTKGSLEEEKRRAA------DALEEQQRCISELKAETRSLVEQHKRERKELEE 759
              +  LK  K +++  K +        +AL+EQ   + E   E   + + H  E+ +L  
Sbjct: 290  RQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ---LDERLQELEKIKDLHMAEKTKLIT 346

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
            +    K L  +L+Q      AET   +R++ E +  +    ++    +K++    E   +
Sbjct: 347  QLRDAKNLIEQLEQDKGMVIAET---KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403

Query: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQ-EAKEKVAGIESHSELQISRQQNELAELH 878
             +++  +      E+ ++  ++ E+AR++L+ E  E++  IE  SE +    Q EL+ + 
Sbjct: 404  QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463

Query: 879  ANLARALQQVQEKEV-RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL 937
              +   +++  E+++ + QKL +             KE+AR E  + K  + +E   +E 
Sbjct: 464  QEVVDVMKKSSEEQIAKLQKLHE-------------KELARKEQELTKKLQTREREFQEQ 510

Query: 938  VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE 997
            +K        Q E+L+  Q ++    Q +L   E E ++        +A L ES+ + ++
Sbjct: 511  MKVALEKS--QSEYLKISQEKE---QQESLALEELELQK--------KAILTESENKLRD 557

Query: 998  ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALT 1057
             + + E    R+ +     +  L   K    +L + L+   N+   E   + E     L 
Sbjct: 558  LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617

Query: 1058 EKEGKDQEL--AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE---HASGSGAQSEAA 1112
              + +   L   KL+ L+     E+E+LR+  +Q KE L K +KE    A       +  
Sbjct: 618  SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK-DKEIIFQAHIEEMNEKTL 676

Query: 1113 GRTEPTGPKLEALRAEVS-------KLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
             + +    +LE+L +E+S       KLE++    ++Q D +++ LEA+     +++   +
Sbjct: 677  EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE--QKNHHQQ 734

Query: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTK----VQDHSKAEDEWKAQVARGRQEAE 1221
             +   ++E    +  ++ AL     +L     +    +++H    +  +A + R   E +
Sbjct: 735  QVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ 794

Query: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
            + ++ +   +   S  + Q    E +  +L+       +K   LE    LL  + A   A
Sbjct: 795  QASAKLDVFQSYQSATHEQTKAYEEQLAQLQ-------QKLLDLETERILLTKQVAEVEA 847

Query: 1282 RAAERSSAL---REEVQSLREEAEKQRVASENLRQELTSQAE-RAEELGQELKAWQEKFF 1337
            +  +  + L   + +VQ L ++ EKQ    E   + LT   E + E+  +E +  ++   
Sbjct: 848  QKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 907

Query: 1338 QKEQALSTLQLEHTSTQALVSELLPAKH-LCQQLQAEQAAAEKRHREELEQSKQAAGGLR 1396
            +KE  +  ++        ++++ L AK      L  E     K   +++E+ KQ A    
Sbjct: 908  EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA---- 963

Query: 1397 AELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE 1456
                   +E+ E   L++K+ +QE    +L+ E  + A +LS  +K              
Sbjct: 964  -------KEMQET--LKKKLLDQEA---KLKKELENTALELSQKEK-------------- 997

Query: 1457 RANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK 1516
                  QF    L+ A     Q  +A  +DA +RL   Q+E      ++E +T  +    
Sbjct: 998  ------QFNAKMLEMA-----QANSAGISDAVSRLETNQKE------QIESLTEVHRREL 1040

Query: 1517 VKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQ 1576
              V+   ++   ++ +   ++ ++++ ++EQ  +V EL +K+       +   +++  ++
Sbjct: 1041 NDVISIWEKKLNQQAEELQEIHEIQLQEKEQ--EVAELKQKILLFGCEKEEMNKEITWLK 1098

Query: 1577 AQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR 1636
             +G +       LQ QL +  A ++   Q     K  +EK +   +   ++N  LQEQL 
Sbjct: 1099 EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV 1158

Query: 1637 SLEQLQKENK----ELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
             L+ L +E+K    EL ++ +    E Q      +++ ++    + + + L  ++A
Sbjct: 1159 ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  228 bits (580), Expect = 6e-59
 Identities = 359/1631 (22%), Positives = 702/1631 (43%), Gaps = 239/1631 (14%)

Query: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
            ++  LK  +        +LE EL+   +LL EK+ QI  +Q+ ID   L N K   S   
Sbjct: 555  EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS--- 611

Query: 275  PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
               LE + D  +     + +TL    D +T      R+   L  EN +L  K++E A+  
Sbjct: 612  -YSLESIEDPKQ-----MKQTL---FDAETVALDAKRESAFLRSENLELKEKMKELATTY 662

Query: 335  QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS------ 388
            +Q+++ + +L +   +A +   + Q  LEKEL +A  +   + +   ++ GK+       
Sbjct: 663  KQMENDI-QLYQSQLEAKK---KMQVDLEKELQSAFNE---ITKLTSLIDGKVPKDLLCN 715

Query: 389  -QLEEHLSQLQD--NPPQEKGEVL-GDVLQLETLKQEAATLAANNTQLQARVEMLETERG 444
             +LE  ++ LQ   N   E+ E L  +V+ L  LK   + +     ++Q + E L     
Sbjct: 716  LELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITS 775

Query: 445  QQEAKLLAERGHFEEEKQQLSSLI----TDLQSSISNLSQAKEELEQASQAH-------- 492
            +++ KL +E  H E   Q L   I     DL ++ SN     +E +     H        
Sbjct: 776  EKD-KLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834

Query: 493  -----GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
                   R+  ++ +L+ E    ++++     EL+   Q+ +EK  ++ + L + EQ   
Sbjct: 835  MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ--- 891

Query: 548  GLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLE 607
             L+ Q+E   S+L+  E++   + EK + T     +++ T  +E++   + +++   + +
Sbjct: 892  -LKEQLENRDSTLQTVEREKTLITEKLQQT----LEEVKTLTQEKDDLKQLQESLQIERD 946

Query: 608  ALEKEKAAKLEI---LQQQLQVANEARDSAQTSV-TQAQREKAELSRKVEELQACVETAR 663
             L+ +    + +    Q+QL+ A E+    Q ++ T   +   E+SR +   +   ET  
Sbjct: 947  QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006

Query: 664  QEQHEAQAQVAELELQLRSEQ--------QKATEKER----VAQEKDQLQEQLQA----- 706
            + Q +      + +L+ ++ Q         +  E++R    + QEK++LQ+ L++     
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066

Query: 707  ------LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
                  LKE++++T  + +EE R   D L++QQ  +++ K        +  R    L E 
Sbjct: 1067 EQLKTDLKENIEMTIEN-QEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV 1125

Query: 761  RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
                + L+ + QQL E  Q    V + E++E     +  E+   +L K      E  E  
Sbjct: 1126 ---EEKLKEKSQQLQEKQQQLLNV-QEEMSEMQKKINEIENLKNEL-KNKELTLEHMETE 1180

Query: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE-------------KVAGIESHSELQI 867
            + E AQ      E++ ++ +E  K  +ELQ++ E             +  G+++  EL+I
Sbjct: 1181 RLELAQKLNENYEEVKSITKE-RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1239

Query: 868  S-----RQQNELAELHANLARALQQV---QEKEVRAQKLADDLSTLQE---------KMA 910
            +       Q  + EL  +++    Q+   Q+ E    KL +++  L E         +++
Sbjct: 1240 AHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299

Query: 911  ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG--RQFCSTQAALQ 968
             T + +  LE L  ++  +  T    +  E  R  ++  E  EE +   ++  + +   +
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359

Query: 969  AMEREAEQMGNELERLRAALMESQGQQQEERGQQERE------VARLTQERGRAQADLAL 1022
            A+E + +Q+   +    A + ESQ +Q++    +E++      V+ + Q + +  A L +
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRI 1419

Query: 1023 EKAARAELEMRLQNALNE------QRVEFATLQEALAHALTE-KEGKDQELAK-LRGLEA 1074
            E      L  RLQ + +E      ++ +   LQE L     + KE   + +AK L   E 
Sbjct: 1420 E-IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 1075 AQIKE--LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
             ++    L+E  +T+ +L+  L++KE E        S    + E    KL+    E+ + 
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETE-------ISTIQKQLEAINDKLQNKIQEIYEK 1531

Query: 1133 EQQCQ-KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ--------- 1182
            E+Q   KQ  +       L+  +  R  +DSAL++++ ++ E    L  SQ         
Sbjct: 1532 EEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKE 1591

Query: 1183 -SALASAQRELAAFRTKVQDHSK---------AEDEWKAQVARGRQEAERKNSLISSLEE 1232
               +   Q  L   R ++++++K          E E++        E + K   I  L+E
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651

Query: 1233 --EVSILNRQVLEKEG--------ESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR 1282
              E   LN + +E E         E+ E  R V  E +  + +EE L++ + +   N   
Sbjct: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1711

Query: 1283 AAERSSALREEVQSLREEAEKQRVASENLR-------QELTSQAERAEELGQELKAWQEK 1335
               R    +EE++ +    ++ +   + LR        E+++  +  E     LKA Q+ 
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA-QDL 1770

Query: 1336 FFQKEQALSTLQLEH-----TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
              Q+E  ++ + L+         + +VSE        Q+      A  +   +EL+ ++ 
Sbjct: 1771 KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEH 1830

Query: 1391 AAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
                L+ ++   Q+++ E+  L++++ +Q  T  +L        E L++ +K H  L E 
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE------IENLNLAQKLHENLEEM 1884

Query: 1451 NRGLGERANLGR--QFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
               + ER NL R  + L++E DQ +E  +QE  A       R  E+Q+E + TAR L   
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKES-LQETKA-------RDLEIQQELK-TARMLS-- 1933

Query: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
                        E ++   + R+K++ +  Q+   Q++  K  +EL KK+       ++Q
Sbjct: 1934 -----------KEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI------QELQ 1976

Query: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN 1628
            +++L+ +            R++  +N    ++++ EQ  + ++ Q    ++      Q  
Sbjct: 1977 KKELQLL------------RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024

Query: 1629 QELQEQLRSLEQLQKENKELRAEAERLGHELQQ--AGLKTKEAEQTCRH-LTAQVRSLEA 1685
            ++L E L  +  + KE  ELR   E L  E  Q  A L+   A     H +  + R L  
Sbjct: 2025 KKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSD 2084

Query: 1686 QVAHADQQLRD 1696
               H  + LR+
Sbjct: 2085 GQQHLTESLRE 2095



 Score =  216 bits (550), Expect = 2e-55
 Identities = 342/1575 (21%), Positives = 682/1575 (43%), Gaps = 185/1575 (11%)

Query: 263  LLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGD 322
            LLN++   S     EL  LR   ++L +         + L+TEK +M+ K   L E+N  
Sbjct: 490  LLNQENIES-----ELNSLRADYDNLVL-------DYEQLRTEKEEMELK---LKEKNDL 534

Query: 323  LSFKLREFASHLQQLQDALNELTE-----EHSKATQEWLEKQAQLEKELSAALQDK-KCL 376
              F+  E  +   Q    ++E++      +H++   + LE +   + EL    +D+ K L
Sbjct: 535  DEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKL 594

Query: 377  EE--KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA 434
            +E   ++ L+     L   L  ++D P Q K  +          K+E+A L + N +L+ 
Sbjct: 595  QEYIDSQKLENIKMDLSYSLESIED-PKQMKQTLFDAETVALDAKRESAFLRSENLELKE 653

Query: 435  RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH-- 492
            +++ L T   Q E  +   +   E +K+    L  +LQS+ + +++    ++        
Sbjct: 654  KMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLL 713

Query: 493  -GARLTAQVASLTSELTTL---NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
                L  ++  L  EL      N  ++++   L+ LK    E + +L + +Q + +    
Sbjct: 714  CNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVE-RLRKEIQDKSEELHI 772

Query: 549  LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHA----QQLATAAEEREASLRERDAALK 604
            +  + ++L S +  KE +++ + E+   T+ D A       +T  E +       D   K
Sbjct: 773  ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQK 832

Query: 605  QLEALEKEKAAKLEI--LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA 662
                LE+ +    EI  L ++ Q  + +  + +T ++   +E  E +R+V+E    +E  
Sbjct: 833  YKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL 892

Query: 663  RQ--EQHEAQAQVAELELQLRSE--QQKATEKERVAQEKD---QLQEQLQALKESLKVT- 714
            ++  E  ++  Q  E E  L +E  QQ   E + + QEKD   QLQE LQ  ++ LK   
Sbjct: 893  KEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI 952

Query: 715  ------KGSLEEEKRRAADALEEQQRCISELKAE-----TRSL-VEQHKRERK-ELEEER 761
                      +E+ R A ++L++ Q  I+ LK++     +R+L +E++  E K E +++ 
Sbjct: 953  HDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012

Query: 762  AG---RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
             G   ++ LEA+  Q   A   + E++ ++       Q   ++E +Q+++ V A +E+ +
Sbjct: 1013 VGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE--KNELQQMLESVIAEKEQLK 1070

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
               +E  +     QE+L  L +E +K ++ +  A+EK   I+   EL  SR  + LAE+ 
Sbjct: 1071 TDLKENIEMTIENQEELRLLGDELKKQQEIV--AQEKNHAIKKEGEL--SRTCDRLAEVE 1126

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG---EQQETASR 935
              L    QQ+QEK+ +   + +++S +Q+K+     E+  L+  ++      E  ET   
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI----NEIENLKNELKNKELTLEHMETERL 1182

Query: 936  ELVK------EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG----NELERLR 985
            EL +      E  ++  ++ + L+E Q + F + +  L+   RE E  G     EL+   
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQ-KSFETERDHLRGYIREIEATGLQTKEELKIAH 1241

Query: 986  AALMESQGQQQEERGQQEREVARL--TQERGRAQADLALEKAARAELEMRLQNALN-EQR 1042
              L E Q    E R     + A++  TQ+  ++   L  E     E +  L N     + 
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301

Query: 1043 VEFATLQEALAHALTEKEGKDQ---ELAKLRGLEAAQ-----IKELEELRQTVKQLKEQL 1094
             E     E L    T K+       E+ +LR  E  Q     IK L + R  +K +KE L
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361

Query: 1095 AKKE---KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE 1151
              K    KEH   + A+ + +   +     ++    E +K+  + ++ + +  +L R +E
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR-IE 1420

Query: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA-FRTKVQDHSKAEDEWK 1210
             E    ++R          + ++  +L   Q  L S   +L    +  V  H + E+E K
Sbjct: 1421 IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK 1480

Query: 1211 AQVARGRQEAERKNSL----------ISSLEEEVSILNRQVLEKEGE--SKELKRLVMAE 1258
                  +++ E  N L          IS++++++  +N ++  K  E   KE +  +   
Sbjct: 1481 VAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQI 1540

Query: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSAL---------REEVQSLREEAEKQRVASE 1309
            SE  +K+ E  +  +   A +SA  +  S  L         +EE+Q + +E E+ +   E
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600

Query: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQ--KEQALSTLQLEHTSTQALVSELLPAKHLC 1367
             L+ E     E  +E+  ++K  QEK +Q  K  A++  Q +    + L  +    K   
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL 1660

Query: 1368 QQLQAEQAAAEKRHREELEQSK---------------------QAAGGLRAELLRAQREL 1406
            + ++ E     +   E LE+ +                     Q    LR  + R   + 
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQ 1720

Query: 1407 GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK----AHGLLAEENRGLGERANLGR 1462
             EL  +   + E + T  +LR   +    ++S ++K    ++  L  ++  + E   +  
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780

Query: 1463 QFLEVE---LDQAR---EKYVQELAAVRADAETRLAEVQREAQST-ARELEVMTAKYE-- 1513
              L+ +   +D+ R    +   +L+ ++ D E   A++Q + Q   A E +++T K +  
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840

Query: 1514 --GAKVKVLEERQRFQEER---------------QKLTAQVEQLE--VFQREQTKQVEEL 1554
                KV  +E+ ++  +++               QKL   +E+++  + +R+  ++VEE 
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900

Query: 1555 SK----KLADSDQASKVQ----QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
             K    +L +S Q +K +    QQ+LK  +    E ++   +L+ +++E   Q+S  ++ 
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKD 1960

Query: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666
             +  K +++K       K+ Q   ++E +    +   E ++L+ + E     +Q   +  
Sbjct: 1961 LDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDN 2020

Query: 1667 KEAEQTCRHLTAQVR 1681
             +  +       ++R
Sbjct: 2021 FQLTKKLHESLEEIR 2035



 Score =  216 bits (549), Expect = 2e-55
 Identities = 359/1700 (21%), Positives = 722/1700 (42%), Gaps = 209/1700 (12%)

Query: 208  ILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEK 267
            +L+  + ++  LKKQL +         +E  +  +LL EKD    +  ++I+ L  +   
Sbjct: 344  LLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVT 403

Query: 268  QAASPLEPK--------------ELEELRDKN--------ESLTMRLHE----------- 294
             ++  L+ +              ++ ++++ N         ++T + H+           
Sbjct: 404  SSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDE 463

Query: 295  -----------TLKQCQDLK-------TEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
                       TL    +++         +  ++ ++N L  +  +L     +  +  ++
Sbjct: 464  SVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEE 523

Query: 337  LQDAL---NELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS----- 388
            ++  L   N+L E  +   +   +++ QL  E+S      K  E  N+ L+ +LS     
Sbjct: 524  MELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVEL 583

Query: 389  --QLEEHLSQLQ----------------------DNPPQEKGEVLGDVLQLETLKQEAAT 424
              + E+ + +LQ                      ++P Q K  +          K+E+A 
Sbjct: 584  LREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF 643

Query: 425  LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE 484
            L + N +L+ +++ L T   Q E  +   +   E +K+    L  +LQS+ + +++    
Sbjct: 644  LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSL 703

Query: 485  LE---QASQAHGARLTAQVASLTSEL---TTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538
            ++            L  ++  L  EL      N  ++++   L+ LK    E + +L + 
Sbjct: 704  IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVE-RLRKE 762

Query: 539  LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD----HAQQLATAAEEREA 594
            +Q + +    +  + ++L S +  KE +++ + E+   T+ D     +   +T  E +  
Sbjct: 763  IQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF 822

Query: 595  SLRERDAALKQLEALEKEKAAKLEI--LQQQLQVANEARDSAQTSVTQAQREKAELSRKV 652
                 D   K    LE+ +    EI  L ++ Q  + +  + +T ++   +E  E +R+V
Sbjct: 823  KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV 882

Query: 653  EELQACVETARQ--EQHEAQAQVAELELQLRSE--QQKATEKERVAQEKD---QLQEQLQ 705
            +E    +E  ++  E  ++  Q  E E  L +E  QQ   E + + QEKD   QLQE LQ
Sbjct: 883  QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942

Query: 706  ALKESLKV-------TKGSLEEEKRRAADALEEQQRCISELKAE-----TRSL-VEQHKR 752
              ++ LK             +E+ R A ++L++ Q  I+ LK++     +R+L +E++  
Sbjct: 943  IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG 1002

Query: 753  ERK-ELEEERAG---RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
            E K E +++  G   ++ LEA+  Q   A   + E++ ++       Q   ++E +Q+++
Sbjct: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE--KNELQQMLE 1060

Query: 809  EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
             V A +E+ +   +E  +     QE+L  L +E +K +QE+  A+EK   I+   EL  S
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK-QQEI-VAQEKNHAIKKEGEL--S 1116

Query: 869  RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG- 927
            R  + LAE+   L    QQ+QEK+ +   + +++S +Q+K+     E+  L+  ++    
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI----NEIENLKNELKNKEL 1172

Query: 928  --EQQETASRELVK------EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG- 978
              E  ET   EL +      E  ++  ++ + L+E Q + F + +  L+   RE E  G 
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ-KSFETERDHLRGYIREIEATGL 1231

Query: 979  ---NELERLRAALMESQGQQQEERGQQEREVARL--TQERGRAQADLALEKAARAELEMR 1033
                EL+     L E Q    E R     + A++  TQ+  ++   L  E     E +  
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291

Query: 1034 LQNALN-EQRVEFATLQEALAHALTEKEGKDQ---ELAKLRGLEAAQ-----IKELEELR 1084
            L N     +  E     E L    T K+       E+ +LR  E  Q     IK L + R
Sbjct: 1292 LPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351

Query: 1085 QTVKQLKEQLAKKE---KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
              +K +KE L  K    KEH   + A+ + +   +     ++    E +K+  +  +Q +
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSE-MEQFK 1410

Query: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA-FRTKVQ 1200
              DS    +E E    ++R          + ++  +L   Q  L S   +L    +  V 
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVA 1470

Query: 1201 DHSKAEDEWKAQVARGRQEAERKNSL----------ISSLEEEVSILNRQVLEKEGE--S 1248
             H + E+E K      +++ E  N L          IS++++++  +N ++  K  E   
Sbjct: 1471 KHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE 1530

Query: 1249 KELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL---------REEVQSLRE 1299
            KE +  +   SE  +K+ E  +  +   A +SA  +  S  L         +EE+Q + +
Sbjct: 1531 KEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIK 1590

Query: 1300 EAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQ--KEQALSTLQLEHTSTQALV 1357
            E E+ +   E L+ E     E  +E+  ++K  QEK +Q  K  A++  Q +    + L 
Sbjct: 1591 EKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLK 1650

Query: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA---GGLRA--ELLRAQR-ELGELIP 1411
             +    K   + ++ E     +   E LE+ +        LR+  E L+ +R +L E   
Sbjct: 1651 EQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE--N 1708

Query: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD- 1470
            LR+ +       ++L+       E    + K  G+++E+     E +N+ +  LE   D 
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT---NEISNMQKD-LEHSNDA 1764

Query: 1471 -QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529
             +A++  +QE   +   A   L E Q         +   T K    +  +     + QE+
Sbjct: 1765 LKAQDLKIQEELRI---AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK 1821

Query: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589
             Q+L A   QL   +    K V E  KK+++ +Q  K  + +   +     E+   AQ+L
Sbjct: 1822 IQELKANEHQLITLK----KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877

Query: 1590 QAQLNELQAQLSQKE---QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK 1646
               L E+++ + +++   +  E  KL+ ++ K      K ++ E+Q++L++   L KE+K
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHK 1937

Query: 1647 E-LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATD 1705
            E +    E++  +  Q     K+ +++   L  +++ L+ +     +   D+       +
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN 1997

Query: 1706 ALKSREPQAKPQLDLSIDSL 1725
             ++  + Q + Q +LS+ S+
Sbjct: 1998 EMEQLKKQFEAQ-NLSMQSV 2016



 Score =  204 bits (520), Expect = 6e-52
 Identities = 358/1662 (21%), Positives = 691/1662 (41%), Gaps = 212/1662 (12%)

Query: 146  DLENFLQKAPVPSTCSSTFPEELSPPSHQAKREI--RFLELQKVASSSSGNNFLSGSPAS 203
            DLE  LQ A    T  ++  +   P       E+  +  +LQK  +     N        
Sbjct: 685  DLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVI 744

Query: 204  PMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL 263
             + ++   P  ++ RL+K++ D+    +EL +  +E  KL +E    +   + R+  L  
Sbjct: 745  LLSELKSLPS-EVERLRKEIQDKS---EELHIITSEKDKLFSE----VVHKESRVQGLL- 795

Query: 264  LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDL 323
                        +E+ + +D   +       T ++ Q+ KT     ++K   + EEN  +
Sbjct: 796  ------------EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERM 843

Query: 324  SFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
            + ++   +   Q+   +L  L  E S  TQE  EK  ++++ L+   Q K+ LE ++  L
Sbjct: 844  NQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTL 903

Query: 384  QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443
            Q     +E   + + +   Q   EV     + + LKQ   +L     QL++ +       
Sbjct: 904  Q----TVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMN 959

Query: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS-------NLSQAKEELEQASQAHGARL 496
               + +L       ++ ++ +++L + +   +S       N  + K+E +Q       + 
Sbjct: 960  IDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ 1019

Query: 497  TAQVASLTSELT--TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
              + A  T  LT    +  I +Q +++  L Q+  E Q  L   + ++EQ    L+  +E
Sbjct: 1020 DLE-AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 555  QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
                + ++      E+ ++QE   Q+        A ++E  L      L ++E   KEK+
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQE-----KNHAIKKEGELSRTCDRLAEVEEKLKEKS 1133

Query: 615  AKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR----QEQHEAQ 670
             +L+  QQQL    E     Q  + + +  K EL  K   L+  +ET R    Q+ +E  
Sbjct: 1134 QQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH-METERLELAQKLNENY 1192

Query: 671  AQVAEL--ELQLRSEQQKATEKERVAQEKDQLQEQLQAL-------KESLKVTKGSLEEE 721
             +V  +  E ++  E QK+ E ER     D L+  ++ +       KE LK+    L+E 
Sbjct: 1193 EEVKSITKERKVLKELQKSFETER-----DHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247

Query: 722  KRRAADALEEQQRCISELKAE---TRSLVEQHKRERKE---LEEERAGRKGLEARLQQLG 775
            +    + ++E +R +SE  A+   T+ L + H + ++E   L EE+     L   ++++ 
Sbjct: 1248 Q----ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE----LLPNVKEVS 1299

Query: 776  EAHQAETEV-LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQ 834
            E  +   E+ L  E +    +   A  E E+L        E++++S QEE +     ++ 
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERL-----RLNEKFQES-QEEIKSLTKERDN 1353

Query: 835  LMTLKEECEKARQELQE-AKEKVAGI-ESHSELQISRQQNELAELHANLARALQQVQEK- 891
            L T+KE  E    +L+E  +E +A I ES S+ + S    E       +   ++Q + K 
Sbjct: 1354 LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKD 1413

Query: 892  ------EVRAQKLADDLSTLQEKMAATSKE---VARLETLVRKAGEQQETASRELVKEPA 942
                  E+    L+  L    ++M + +KE   + RL+ +++   +Q +   +E+V +  
Sbjct: 1414 SALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHL 1473

Query: 943  RAGD----------RQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQ 992
               +           Q E + E +       +  +  ++++ E + ++L+     + E +
Sbjct: 1474 ETEEELKVAHCCLKEQEETINELR-VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532

Query: 993  GQ----QQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE------QR 1042
             Q    Q  E  ++  E+ +  + R    + L   ++   EL  RLQ +  E      ++
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592

Query: 1043 VEFATLQEALAHALTE-KEGKDQELAKLRG--------LEAAQIKELEELRQTVKQLKEQ 1093
             E   +QEAL     + KE   + +AK++         L+   + E +E    ++ LKEQ
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652

Query: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRA------------EVSKLEQQCQKQQE 1141
                E +  +    ++E    T+     LE +R+            E  K+E+  Q ++ 
Sbjct: 1653 F---ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD-QLKEN 1708

Query: 1142 QADSLERSLEAERASR------AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195
              +++ R LE +   +       E    ++ L+G + EK  E+ + Q  L  +   L A 
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768

Query: 1196 RTKVQDHSKAE----DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESK-- 1249
              K+Q+  +       E +  + + R     K   +S++++++   N ++ EK  E K  
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828

Query: 1250 -----ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALR------EEVQSLR 1298
                  LK+ V    +K  ++E+  + ++ ++ + S    E  +  +      EE++S+ 
Sbjct: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888

Query: 1299 EEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS 1358
            +E +  R   E L+ E     ++ +E  QE KA   +  Q+ +    L  EH  T   + 
Sbjct: 1889 KERDNLRRVEETLKLE----RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944

Query: 1359 ELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAE 1418
            E +  K +  Q+   Q   +K  ++EL++  Q       +LLR + ++       +K+ E
Sbjct: 1945 EKISEKTI--QISDIQKDLDK-SKDELQKKIQELQKKELQLLRVKEDVN---MSHKKINE 1998

Query: 1419 QERTAQQLRAEKASY----AEQLSMLKKAHGLLAEENRGLGERANLGR--QFLEVELDQ- 1471
             E+  +Q  A+  S      +   + KK H  L E      ER  L R  + L++E DQ 
Sbjct: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQF 2058

Query: 1472 --------AREK---YVQELAAVRADAETRLAEVQREAQSTAREL----EVMTAKYE--G 1514
                    AR++    V+    + +D +  L E  RE  S  +EL      M   YE   
Sbjct: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLN 2118

Query: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
                 LE+   FQ+E   L+ +V+        QTK +E+L               +KLK 
Sbjct: 2119 RLSLDLEKEIEFQKE---LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY 2175

Query: 1575 VQAQGGESQQEAQRL--QAQLNELQAQLSQKEQAAEHYKLQME---KAKTHYDAKKQQNQ 1629
            V +   + ++E      + +++ +     QKE   +   LQ +    ++   D K  QN 
Sbjct: 2176 VLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235

Query: 1630 ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQ 1671
            +L      +E++ K+  E  +E   +  E QQ     KE  Q
Sbjct: 2236 DLH-----IEEILKDFSE--SEFPSIKTEFQQVLSNRKEMTQ 2270



 Score =  133 bits (335), Expect = 2e-30
 Identities = 230/1180 (19%), Positives = 491/1180 (41%), Gaps = 133/1180 (11%)

Query: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
            +E   + Q + T    +      +V   +A ++  R+E  + + Q+ E+ L+ R++  + 
Sbjct: 314  DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK 373

Query: 688  TEKERVAQEKDQLQ----EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL-KAE 742
             +  ++ +EKD LQ    E+++ L   L VT  SL  ++   A        C+ ++ K +
Sbjct: 374  DQLAQLLEEKDLLQKVQNEKIENLTRML-VTSSSLTLQQELKAKRKRRVTWCLGKINKMK 432

Query: 743  TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESE 802
              +  +Q         +       L   L+++ E+  +E++V    L      +    ++
Sbjct: 433  NSNYADQFNIPTNITTKTHKLSINL---LREIDESVCSESDVFSNTLDTLSEIEWNPATK 489

Query: 803  C---EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE---KARQELQEAKEKV 856
                E +  E+ + R  Y++          +  EQL T KEE E   K + +L E +   
Sbjct: 490  LLNQENIESELNSLRADYDNL--------VLDYEQLRTEKEEMELKLKEKNDLDEFEALE 541

Query: 857  AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
               +   E+Q+  + + L  L          V+  EV  Q L ++LS+  E +     ++
Sbjct: 542  RKTKKDQEMQLIHEISNLKNL----------VKHAEVYNQDLENELSSKVELLREKEDQI 591

Query: 917  ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ 976
             +L+       E  ++   E +K          E  ++ +   F +   AL A    A  
Sbjct: 592  KKLQ-------EYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFL 644

Query: 977  MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQN 1036
                LE     L E   +      Q E ++          Q+ L  +K  + +LE  LQ+
Sbjct: 645  RSENLE-----LKEKMKELATTYKQMENDIQLY-------QSQLEAKKKMQVDLEKELQS 692

Query: 1037 ALN---------------------EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAA 1075
            A N                     E   +   LQ+ L   + E E   +E+  L  L++ 
Sbjct: 693  AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSL 752

Query: 1076 QIKELEELRQTVKQLKEQL----AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
               E+E LR+ ++   E+L    ++K+K  +     +S   G  E  G   + L    S 
Sbjct: 753  P-SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811

Query: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
             +   Q+ Q    +L    E +     E +  +      L ++AQ+     S+L + + E
Sbjct: 812  YKSTDQEFQ-NFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF---DSSLGALKTE 867

Query: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251
            L+    ++Q+ ++   E   ++ + +++ E ++S + ++E E +++  ++ +   E K L
Sbjct: 868  LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927

Query: 1252 KRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENL 1311
             +    E +  ++L+E L++ + +  S+       +   +E++++  E  ++ +     L
Sbjct: 928  TQ----EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983

Query: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ-LEHTSTQALVSELLPAKHLCQQL 1370
            + +++ +  R   + +     +++F QK   +   Q LE  +TQ L +++   + + QQ 
Sbjct: 984  KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043

Query: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430
            +      EK   +++ +S      + AE  + + +L E I +  +  E+ R    L  ++
Sbjct: 1044 KIFSLIQEKNELQQMLES------VIAEKEQLKTDLKENIEMTIENQEELR----LLGDE 1093

Query: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREK--YVQELAAVRADAE 1488
                +++   +K H +  E     GE +    +  EVE ++ +EK   +QE      + +
Sbjct: 1094 LKKQQEIVAQEKNHAIKKE-----GELSRTCDRLAEVE-EKLKEKSQQLQEKQQQLLNVQ 1147

Query: 1489 TRLAEVQR---EAQSTARELEVMTAKYEGAKVKVLEERQRFQ---EERQKLTAQVEQLEV 1542
              ++E+Q+   E ++   EL+      E  + + LE  Q+     EE + +T + + L+ 
Sbjct: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKE 1207

Query: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ-LS 1601
             Q+    + + L   + + +      +++LK       E Q+    L+  ++E  AQ ++
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN 1267

Query: 1602 QKEQAAEHYKLQMEKAKTHYDAKKQQN----QELQEQLRSLEQLQKENKE------LRAE 1651
             ++    H KLQ E    H + +   N     E QE +  LE L +++         R E
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327

Query: 1652 AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711
             ERL     +   K +E+++  + LT +  +L+  +  A +   D  K  +     K +E
Sbjct: 1328 MERL-----RLNEKFQESQEEIKSLTKERDNLKT-IKEALEVKHDQLKEHIRETLAKIQE 1381

Query: 1712 PQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSV 1751
             Q+K +      SL++  ++     I S++ + +P  +++
Sbjct: 1382 SQSKQE-----QSLNMKEKDNETTKIVSEMEQFKPKDSAL 1416



 Score =  132 bits (331), Expect = 5e-30
 Identities = 241/1224 (19%), Positives = 520/1224 (42%), Gaps = 170/1224 (13%)

Query: 207  DILQTPQFQMRRLKKQLADERSNRDELELELA------------ENRKLLTEKDAQIAMM 254
            ++LQ+   Q++   K++  +    +E EL++A            E R  L+EK+ +I+ +
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEE-ELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510

Query: 255  QQRIDRL--ALLNEKQAASPLEP----KELEELRDK-NESLTMRLHETLKQCQDLKTEKS 307
            Q++++ +   L N+ Q     E     K++ E+++K NE    + H   K    L++ +S
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA-LQSIES 1569

Query: 308  QMDRKINQLSEENGDLSFKLRE------FASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
            +M    N+L E   ++   ++E          LQ  +D L E T+E     +E  EK+ Q
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629

Query: 362  LEKELSA-ALQDKKC----LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416
              K  +    Q+K C    L+E+ E  +  L  +E    +L     +   E+     + +
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689

Query: 417  TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476
             L+    TL     QL+  +    T   +++ +L     H +E ++ +  L   +    +
Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN 1749

Query: 477  NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLA 536
             +S  +++LE ++ A    L AQ   +  EL   +  +++Q + +  L+    EK  +L+
Sbjct: 1750 EISNMQKDLEHSNDA----LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805

Query: 537  QTLQQQEQASQGLRHQVEQLS--------------------SSLKQKEQQLKEVA---EK 573
               +  E ++  L+ ++++L                     S ++Q ++Q+K+ +    K
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865

Query: 574  QEATRQDHAQQLATAAEEREASLRERDAALK----------QL-EALEKEKAAKLEILQQ 622
             E    + AQ+L    EE ++ ++ERD   +          QL E+L++ KA  LEI QQ
Sbjct: 1866 LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI-QQ 1924

Query: 623  QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
            +L+ A       + +V + + + +E + ++ ++Q  ++ ++ E  +   ++ + ELQL  
Sbjct: 1925 ELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLR 1984

Query: 683  EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
             ++      +   E +QL++Q +A   S++  +    +  ++  ++LEE  R +++ + E
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI-RIVAKERDE 2043

Query: 743  TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESE 802
             R + E  K ER +     A  + + AR +Q    HQ + E  +R L++    QH  ES 
Sbjct: 2044 LRRIKESLKMERDQFI---ATLREMIARDRQ---NHQVKPE--KRLLSDGQ--QHLTES- 2092

Query: 803  CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH 862
                                               L+E+C + ++ L+   E     E  
Sbjct: 2093 -----------------------------------LREKCSRIKELLKRYSEMDDHYECL 2117

Query: 863  SELQISRQ-----QNELA-ELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
            + L +  +     Q EL+  + ANL+  L  +Q K +     A+   +++       K++
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLS--LPYLQTKHIEKLFTANQRCSME--FHRIMKKL 2173

Query: 917  ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEE-QQGRQFCSTQAALQAMEREAE 975
              + + V K  E+Q  +  +   +     ++Q E L + Q  +Q C   +      +  +
Sbjct: 2174 KYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ 2233

Query: 976  QMGNELERLRAALMESQGQQQEERGQQ----EREVARLTQERGRAQADLA-LEKAARAEL 1030
             M   +E +     ES+    +   QQ     +E+ +  +E    + D+  L+   + E 
Sbjct: 2234 NMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN 2293

Query: 1031 EM--RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL-EELRQTV 1087
            +   ++ N  N + +       A+ +  TE E +   ++K    +   +KE  E+L +  
Sbjct: 2294 DRICQVNNFFNNRII-------AIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNY 2346

Query: 1088 KQLKEQLAKKEKEHASGSGAQSE--AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADS 1145
            + LK  LA   + + +    ++    +  T+ T  K+  L   + + ++    ++ +   
Sbjct: 2347 QTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIK 2406

Query: 1146 LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA----FRTKVQD 1201
            +++ LE         +  +  LQ ++ E  + L  ++  +   Q ++A     ++ +++D
Sbjct: 2407 MQKELEVT-------NDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459

Query: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEE---EVSILNRQVLEKEGESKELKRLVMAE 1258
                  +   +  +  +E E++ S   +  E   EV  L R+ L +  ++++    V++E
Sbjct: 2460 LKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTS--VISE 2517

Query: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSAL--REEVQSLREEAEKQRVASENLRQELT 1316
                Q   + L      T    +   + + AL  + E   L +E  K +  +E L ++  
Sbjct: 2518 HTDPQPSNKPL------TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKN 2571

Query: 1317 SQAERAEELGQELKAWQEKFFQKE 1340
                  + L  E+K W+E+  ++E
Sbjct: 2572 ELLSNNQHLSNEVKTWKERTLKRE 2595



 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 197/1082 (18%), Positives = 425/1082 (39%), Gaps = 177/1082 (16%)

Query: 843  EKARQELQEAKEKVAGIESHSELQISRQQNELAEL--HANLARALQQVQEKEVRAQKLAD 900
            ++ R+E+ + K+++  +   +  Q + ++++LA+L    +L + +Q  + + +    +  
Sbjct: 346  KRYRKEIMDLKKQLEEVSLETRAQ-AMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTS 404

Query: 901  DLSTLQEKMAATSKE-----VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQ 955
               TLQ+++ A  K      + ++  +       Q      +  +  +        ++E 
Sbjct: 405  SSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDES 464

Query: 956  ---QGRQFCSTQAALQAME-------REAEQMGNELERLRAALMESQGQQQEERGQQERE 1005
               +   F +T   L  +E          E + +EL  LRA         ++ R ++E  
Sbjct: 465  VCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEM 524

Query: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
              +L ++    + + ALE+  + + EM+L +       E + L+  + HA    +  + E
Sbjct: 525  ELKLKEKNDLDEFE-ALERKTKKDQEMQLIH-------EISNLKNLVKHAEVYNQDLENE 576

Query: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
            L+       ++++ L E    +K+L+E +  ++ E+                   K++ L
Sbjct: 577  LS-------SKVELLREKEDQIKKLQEYIDSQKLENI------------------KMD-L 610

Query: 1126 RAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
               +  +E   Q +Q   D+   +L+A+R S   R   LE     L+EK +EL  +   +
Sbjct: 611  SYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE-----LKEKMKELATTYKQM 665

Query: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE 1245
               + ++  ++++++   K + + + ++     E  +  SLI     +  + N   LE E
Sbjct: 666  ---ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCN---LELE 719

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREE----- 1300
            G+  +L++ +  E E+++ L E + LL     S           LR+E+Q   EE     
Sbjct: 720  GKITDLQKELNKEVEENEALREEVILL-----SELKSLPSEVERLRKEIQDKSEELHIIT 774

Query: 1301 AEKQRVASENLRQELTSQAERAEELGQ---ELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
            +EK ++ SE + +E   Q    EE+G+   +L   Q  +   +Q     +  H   +   
Sbjct: 775  SEKDKLFSEVVHKESRVQG-LLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY 833

Query: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE----LGELIPLR 1413
              +L       Q     +   ++    L   K        EL    RE    L E+  L+
Sbjct: 834  KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893

Query: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR 1473
            +++  ++ T Q +  EK    E+L    +    L +E   L +     ++ L++E DQ +
Sbjct: 894  EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL----QESLQIERDQLK 949

Query: 1474 --------------EKYVQELAAVRADAET------------------------------ 1489
                          E+    L +++   ET                              
Sbjct: 950  SDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQ 1009

Query: 1490 -RLAEVQREAQSTARELEVMTAKYEGAKV--------KVLEERQRFQEERQKLTAQVEQL 1540
             ++  + ++    A+  + +TA  +  ++         +++E+   Q+  + + A+ EQL
Sbjct: 1010 QKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQL 1069

Query: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
            +   +E  +   E  ++L       K QQ+ +   +    + + E  R   +L E++ +L
Sbjct: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129

Query: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE--NKELRAE------- 1651
             +K Q  +  + Q+          +++  E+Q+++  +E L+ E  NKEL  E       
Sbjct: 1130 KEKSQQLQEKQQQLLNV-------QEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182

Query: 1652 --AERLGHELQQAGLKTKEA----------EQTCRHLTAQVRSLEAQVAHADQQLR---- 1695
              A++L    ++    TKE           E    HL   +R +EA      ++L+    
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242

Query: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEP 1755
             L + Q   D L+    +   Q+   I++ DL   E +   +  ++P    +   +P   
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQI---INTQDL---EKSHTKLQEEIPVLHEEQELLPNVK 1296

Query: 1756 ASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQII 1815
                +Q    ++E L     T   + + A +E     L + F +S  + +S  +    + 
Sbjct: 1297 EVSETQETMNELELLTE-QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355

Query: 1816 NI 1817
             I
Sbjct: 1356 TI 1357


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  225 bits (574), Expect = 3e-58
 Identities = 408/1832 (22%), Positives = 746/1832 (40%), Gaps = 310/1832 (16%)

Query: 84   AQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAE---LAVILKFVLDHEDG 140
            AQ   +  E+E  K+ + L   ST S  + +  E F+ + Q     L +     + HE  
Sbjct: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364

Query: 141  LNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGN-NFLSG 199
            ++  E L+  L+ + +          +++   H  + + +  ELQK+ S    + ++LSG
Sbjct: 1365 VHA-ESLQQKLESSQL----------QIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413

Query: 200  SPASPMGDI--LQTPQFQMRRLKKQL-------ADERSNR-DELELELAENRKLLTE--K 247
              +     +  +QT   +   L K L       A E   R  +L++EL E ++   E  +
Sbjct: 1414 QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473

Query: 248  DAQIAMMQQRIDRLALLNEKQAASPLEPKELEE----LRDKNESLTMRLHETLKQCQDLK 303
            +++     QR  + AL++ K+A    E K L+E     R   E LT  L +   Q     
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALK--ENKSLQEELSLARGTIERLTKSLADVESQVSAQN 1531

Query: 304  TEKSQMDRKINQLSEENGDLSFKL-------REFASHLQQLQDALNELTEEHSKATQE-- 354
             EK  +  ++  L EE   L  ++       +  +S  + L+ AL  LTE+  K  +E  
Sbjct: 1532 KEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591

Query: 355  ------------WLEKQAQLEKELSAALQDKKCLEEKNEILQ--------------GKLS 388
                        W EK  +L+KE    LQ  + +  + E +Q              GKL 
Sbjct: 1592 SLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR 1651

Query: 389  QLE----EHLSQLQDNPPQEKGEVLGD-----------VLQLE---------------TL 418
              E    E   QLQ+   QE  E+              +L+LE               T 
Sbjct: 1652 STEANKKETEKQLQE-AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA 1710

Query: 419  KQEAATLAANNTQLQARVEMLETERGQQEAK---LLAERGHFEEEKQQLSSLITDLQSSI 475
            K+   TL ++N  ++  +E ++ E      K   L++E+    EE Q L   I    S  
Sbjct: 1711 KECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ 1770

Query: 476  SNLSQAK--------------------EELEQASQAHGARLTAQVASLTSELTTLNATIQ 515
            +NL   +                    EE +  S +     +  V S  S    ++    
Sbjct: 1771 ANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFS 1830

Query: 516  QQDQELAGLKQ--QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573
              D+    L+Q  Q KE+ A L +  Q+ ++ SQ L ++   L S +  K+ +LK + E 
Sbjct: 1831 SHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE- 1889

Query: 574  QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
             E T+ +   Q       R   L+E           E+EK    E L  QL   N +  +
Sbjct: 1890 -EVTKMNLLNQQIQEELSRVTKLKE---------TAEEEKDDLEERLMNQLAELNGSIGN 1939

Query: 634  AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE---------- 683
                VT AQ +   L  +++ L+ CV    +E+ +   +  ++E ++R E          
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999

Query: 684  ----QQKATEKERVAQEKDQ-----------LQEQLQALKESLKV-------TKGSLEEE 721
                +  A E + + +EK Q            QE++ AL+ ++K        ++  LE  
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059

Query: 722  KRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE 781
            K   A A+E +++  +EL +    L +      + L +    +K L++  + +    + +
Sbjct: 2060 KENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQK 2119

Query: 782  TEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841
             E L R L +A           E+ +KE    +E+ +  ++E+        E  +TL ++
Sbjct: 2120 DEDLERRLEQAE----------EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169

Query: 842  CEKARQELQE-----AKEKVAGIESHSELQISRQQ--NELAELHANLARALQQVQE---- 890
             +K  Q+LQE       +  A  +S S LQ  R +  +E  +     + A+Q  +E    
Sbjct: 2170 -DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228

Query: 891  KEVRAQKLADDLSTLQEKMAATSKEVARLE--TLVRKAGEQQETASRELVKEPARAGDRQ 948
            KE     L D L  +   M      ++RLE    + ++  Q E   ++ V +  +  +++
Sbjct: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE 2288

Query: 949  PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG---QQERE 1005
                 E+    + S+Q  L  +E E + + ++L  L  +L + + Q+    G   QQE +
Sbjct: 2289 LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD 2348

Query: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
            +        + + DL     A  EL  RL   +N +  +  +L         ++E     
Sbjct: 2349 IQNSKFSYEQLETDLQ----ASRELTSRLHEEINMKEQKIISLLSG------KEEAIQVA 2398

Query: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
            +A+LR     +IKELE L          L+++E+E+        +A  +T      L+ +
Sbjct: 2399 IAELRQQHDKEIKELENL----------LSQEEEENIVLEEENKKAVDKTNQLMETLKTI 2448

Query: 1126 RAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
            + E  +       Q+ Q DS  +S+ +    + +RD  +   Q QLEE+     H    L
Sbjct: 2449 KKENIQ-------QKAQLDSFVKSMSS---LQNDRDRIVGDYQ-QLEER-----HLSIIL 2492

Query: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV----SILNRQV 1241
               Q         +Q+ +   ++ K ++   R   +  NS  + L+ E+      LN+ +
Sbjct: 2493 EKDQL--------IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544

Query: 1242 LEKEGESKELKRLVMAESE----KSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297
              K+ + K+L  + + +++    K  KLEE+L+  ++E A+   R +   +AL+EE Q L
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLK--ESEEANEDLRRS--FNALQEEKQDL 2600

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
             +E E  +V+   L +++T+  E        L  +  +   KE+ +  L    +S+Q  +
Sbjct: 2601 SKEIESLKVSISQLTRQVTALQEEGT-----LGLYHAQLKVKEEEVHRLSALFSSSQKRI 2655

Query: 1358 SELLPAKHLCQQLQAEQAAAE--KRHREELEQSKQAAGGLRAELLRAQRELGEL----IP 1411
            +EL   + +C Q +A +   E   + ++EL+     AG +R E   A+  + EL    + 
Sbjct: 2656 AEL-EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714

Query: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471
            + QK+    +  + L A+  S+   +S L+ +                  R     ELD+
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS------------------RDHANEELDE 2756

Query: 1472 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ 1531
             + KY   L  +    E  L   +R+A  +      M +  E +   + +  Q+   + +
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFS-MNSTEENSLSHLEKLNQQLLSKDE 2815

Query: 1532 KLTAQVEQLEVFQREQTKQVEELSKKLA-----------DSDQASKVQQQKLKAVQAQGG 1580
            +L     QLE    +   QV+  SK +A           + ++  K ++ K ++  AQ  
Sbjct: 2816 QLLHLSSQLE----DSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA-AQPS 2870

Query: 1581 ESQQEAQRLQAQLNELQAQ----LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR 1636
             S  E Q L+  ++ LQ      L + +   + Y LQ+ +  T     K Q QE Q++ +
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQY-LQINQEITELHPLKAQLQEYQDKTK 2929

Query: 1637 SLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ----VRSLEAQVAHADQ 1692
            + + +Q   +ELR E     HEL Q  ++    E   R +  Q    +   + Q++H   
Sbjct: 2930 AFQIMQ---EELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN 2986

Query: 1693 QLRDLGKFQVATDALKSR-EPQAKPQLDLSID 1723
             +R+L      T  LK + + QA P+   S D
Sbjct: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPD 3018



 Score =  223 bits (567), Expect = 2e-57
 Identities = 347/1698 (20%), Positives = 705/1698 (41%), Gaps = 270/1698 (15%)

Query: 208  ILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI-----DRLA 262
            IL+  Q + R L+++L  ++ + + L+ +  E  K       Q+  +Q ++      +L 
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP 1249

Query: 263  LLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGD 322
              +++++ S     E    +   +  T  + E+   C D  +     D    Q       
Sbjct: 1250 STDQQESCSSTPGLEEPLFKATEQHHTQPVLES-NLCPDWPSHSE--DASALQGGTSVAQ 1306

Query: 323  LSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEI 382
            +  +L+E  +   +L+  ++  T E +K ++E  + Q Q+ K+    ++  K +  + E+
Sbjct: 1307 IKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ-GLEIESLKTVSHEAEV 1365

Query: 383  ----LQGKL--SQLE----EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT-LAANNTQ 431
                LQ KL  SQL+    EHL +LQ          L ++ +L + K+E  + L+   ++
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPK--------LDELQKLISKKEEDVSYLSGQLSE 1417

Query: 432  LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
             +A +  ++TE  +QE  + A     E + ++    I  LQ  +  + Q  EE+ + S+A
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477

Query: 492  --------HGARLTAQVA-----SLTSELTTLNATIQQQDQELAGLKQQA----KEKQAQ 534
                      A ++ + A     SL  EL+    TI++  + LA ++ Q     KEK   
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537

Query: 535  LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREA 594
            L +    QE+  +     + ++  SL +  Q L    E  +   +   +      +E E+
Sbjct: 1538 LGRLALLQEERDK----LITEMDRSLLEN-QSLSSSCESLKLALEGLTEDKEKLVKEIES 1592

Query: 595  SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE 654
                + A   + +   KE   + EIL Q  +  +   +  Q  V   ++EK EL  K+  
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652

Query: 655  LQACVETARQEQHEAQAQVAELELQLR----SEQQKATEKERVAQEKDQLQEQL------ 704
             +A  +   ++  EA+ ++ E++ ++R    S+QQK  E E   +E D+L+ ++      
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHPAGDT 1709

Query: 705  -QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAG 763
             +   E+L  +  S++EE  R     E   +    L +E  SL E+ +  + ++E   + 
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769

Query: 764  RKGLEARLQQLGEAHQAE--TEVLRRELAE------------------------AMAAQH 797
            +  LEA  +   + +  E  T+ +  E  E                        A++   
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF 1829

Query: 798  TAESECEQLVKEVAAWRERY---EDSQQEEAQYGAMFQEQ--------------LMTLKE 840
            ++  E    ++++   +ER    E+ +Q+  ++    + +              L  L+E
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE 1889

Query: 841  ECEKAR---QELQEAKEKVAGIESHSELQIS----RQQNELAELHANLARALQQVQEKEV 893
            E  K     Q++QE   +V  ++  +E +      R  N+LAEL+ ++    Q V + ++
Sbjct: 1890 EVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI 1949

Query: 894  RAQKLADDL-------STLQEKMAATSKEVARLETLVRKA------GEQQETASRELVKE 940
            + + L  ++       S L+E+     KE  ++E+ +RK       G Q+E  ++   KE
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE 2009

Query: 941  PARAGDRQPEWLEEQQGRQFCSTQAALQAMEREA---EQMGNELERLRAALMESQGQQQE 997
                   + + +++ Q +     Q  + A+ER     E +  E ++      E+  Q  E
Sbjct: 2010 LQELLKEKQQEVKQLQ-KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068

Query: 998  ERGQQEREVARLT-------QERGRAQAD-LALEKAARA--------------ELEMRLQ 1035
             R + + E+A           E  R  AD L L+K  ++              +LE RL+
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095
             A  +   E   +QE L     EK   ++ + +++     + KE+++L++ +     QLA
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLA 2188

Query: 1096 KKEKEHASGSGAQSEAAGRTEPTGPK----LEALRAEVSKLEQQCQKQQEQADSLERSLE 1151
               K  +S    +       +    K    +++   E+   E  C   ++Q   +   +E
Sbjct: 2189 AFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME 2248

Query: 1152 AERA--SRAERDSAL----------------ETLQG-------QLEEKAQELGHSQSALA 1186
              +   SR E D  +                +TLQG       QLEE       SQ+ LA
Sbjct: 2249 ELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA 2308

Query: 1187 SAQRELAAFRTKVQDHSKAEDEWKAQVAR-----GRQEAERKNS---------------- 1225
              + EL + + ++ D S + ++ K Q         +QEA+ +NS                
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368

Query: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAE--SEKSQKLEERLRLLQAETASN---- 1279
            L S L EE+++  ++++      +E  ++ +AE   +  ++++E   LL  E   N    
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2428

Query: 1280 --SARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK-- 1335
              + +A ++++ L E ++++++E  +Q+   ++  + ++S     + +  + +  +E+  
Sbjct: 2429 EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHL 2488

Query: 1336 --FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK---RHREELEQSKQ 1390
                +K+Q +     E+     L  E+   +     L +E A  +    ++RE+L Q   
Sbjct: 2489 SIILEKDQLIQEAAAENNK---LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545

Query: 1391 AAGGLRAELLRAQ----REL-GELIPLRQKVAEQERTAQQLRA-------EKASYAEQLS 1438
                 + +LL  Q    +EL  +   L +K+ E E   + LR        EK   ++++ 
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605

Query: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA 1498
             LK +   L  +   L E   LG    ++++   +E+ V  L+A+ + ++ R+AE++ E 
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKV---KEEEVHRLSALFSSSQKRIAELEEEL 2662

Query: 1499 QSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKL 1558
                +E      + E    K+ +E +    +   +  + E  E       ++V EL++ L
Sbjct: 2663 VCVQKEAAKKVGEIED---KLKKELKHLHHDAGIMRNETETAE-------ERVAELARDL 2712

Query: 1559 ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAK 1618
             +        +QKL  V        +E + L AQ+      +S  + + +H   ++++ K
Sbjct: 2713 VE-------MEQKLLMVT-------KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758

Query: 1619 THYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTA 1678
              YDA  ++  +L+EQ      L +E   L +E     +  ++  L   E       L  
Sbjct: 2759 RKYDASLKELAQLKEQ----GLLNRERDALLSETAFSMNSTEENSLSHLE------KLNQ 2808

Query: 1679 QVRSLEAQVAHADQQLRD 1696
            Q+ S + Q+ H   QL D
Sbjct: 2809 QLLSKDEQLLHLSSQLED 2826



 Score =  222 bits (565), Expect = 3e-57
 Identities = 349/1640 (21%), Positives = 685/1640 (41%), Gaps = 205/1640 (12%)

Query: 213  QFQ--MRRLKKQLADERSNRDELELELAENR----KLLTEK-DAQIAMMQQRIDRLALLN 265
            QFQ  ++++ + L D+ +  D L+ E++EN+    KL+T   DA         D +AL+ 
Sbjct: 1089 QFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG------DSVALVK 1142

Query: 266  EKQAASP------------LEPK------ELEELRDK-NESLTMRLHETLKQCQD----L 302
            E    SP            LE K      E E+L+ K  E+LT R    LK+ Q+    L
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSR-KAILKKAQEKERHL 1201

Query: 303  KTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT--QEWLEKQA 360
            + E  Q     N+L E+  + S +       L+QLQ  + E  +    +T  QE      
Sbjct: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP 1261

Query: 361  QLEKELSAA---------LQDKKCLE-----EKNEILQG--KLSQLEEHLSQLQDNPPQE 404
             LE+ L  A         L+   C +     E    LQG   ++Q++  L +++    + 
Sbjct: 1262 GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1321

Query: 405  KGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQL 464
            + +V     +L    +E   L     +    +E L+T   + E    + +   E  + Q+
Sbjct: 1322 ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI 1381

Query: 465  SSL--ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA 522
            + L  + +LQ  +  L +   + E+       +L+ + A+LT   T +   I+Q+D   A
Sbjct: 1382 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI---IEQEDLIKA 1438

Query: 523  ---GLKQQAKEK-------QAQLAQTLQQQEQASQGLRHQVE---QLSSSLKQKEQQLKE 569
                L+ QAKE        Q +L +  Q+ E+  +  R + +   +L ++L  +++ LKE
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498

Query: 570  VAEKQE------ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
                QE       T +   + LA    +  A  +E+D  L +L  L++E+   +  + + 
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558

Query: 624  L---QVANEARDSAQTSVTQAQREKAELSRKVEELQA---CVETARQEQHEAQAQVAELE 677
            L   Q  + + +S + ++     +K +L +++E L++      T  QE+H+   +  E E
Sbjct: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK--EYE 1616

Query: 678  LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737
            + L+S +  + E ER+    + ++++ Q L   L+ T+ + +E +++  +A +E +    
Sbjct: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME---- 1672

Query: 738  ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
            E+K + R   +  +++  ELEEE                          R  AE   A  
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEEND------------------------RLRAEVHPAGD 1708

Query: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
            TA+   E L+   A+ +E  E  + E       FQ    +L  E +   +E+Q+ K ++ 
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQ----SLMSEKDSLSEEVQDLKHQIE 1764

Query: 858  GIESHSELQISRQQN-ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
            G        +S+Q N E  E H N     ++  +      +  D LS       + S   
Sbjct: 1765 G-------NVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPS 1817

Query: 917  ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ 976
            A+              ++   V +   + D    +L  QQ  Q     A L+  +++ ++
Sbjct: 1818 AK--------------SANPAVSKDFSSHDEINNYL--QQIDQLKERIAGLEEEKQKNKE 1861

Query: 977  MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA----LEKAARAE--- 1029
                LE  +  L+     +  E    + EV ++     + Q +L+    L++ A  E   
Sbjct: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDD 1921

Query: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
            LE RL N L E         + +  A  + E  + E+  L+   +   +E ++L +   +
Sbjct: 1922 LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTK 1981

Query: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
            ++ ++ K+  E   G+  +       +     L+  + EV +L++ C + QE+  +LER+
Sbjct: 1982 VESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT 2041

Query: 1150 LEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
            ++A    + E    LE  +   E  AQ + H +     AQ ELA+F+  + D        
Sbjct: 2042 VKALEFVQTESQKDLEITK---ENLAQAVEHRK----KAQAELASFKVLLDDTQSEAARV 2094

Query: 1210 KAQVARGRQEAE-RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268
             A   + ++E +  K S+ S ++++   L R++  ++ E K LK        + + ++E+
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRL--EQAEEKHLK--------EKKNMQEK 2144

Query: 1269 LRLLQAETASNSARAAERSSALR---EEVQSLREEAEKQRVASENLRQELTSQAERAEEL 1325
            L  L+ E         E    L    +EVQ L+E  +          + ++S  +  + +
Sbjct: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204

Query: 1326 GQELKAWQEKFFQKEQAL-STLQLEHTSTQALVSELL-------PAKHLCQQLQAEQAAA 1377
              E K W+ KF    Q+    ++L+  +   L  +L          K    +L+ ++   
Sbjct: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264

Query: 1378 EKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQL 1437
            E + + E++  ++    L+ E    +  L +L   R      +    +L +E  S  +QL
Sbjct: 2265 ESKAQTEVQLQQKVCDTLQGE---NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321

Query: 1438 SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497
            + L  +     E+    G    + RQ  E ++  ++  Y Q    ++A  E      +  
Sbjct: 2322 TDLSNSLEKCKEQK---GNLEGIIRQ-QEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377

Query: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQ---EERQKLTAQVEQLEVFQREQTKQVEEL 1554
                 + + +++ K E  +V + E RQ+     +E + L +Q E+  +   E+ K+  + 
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437

Query: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614
            + +L ++ +  K +  + K   AQ     +    LQ   + +     Q E+   H  + +
Sbjct: 2438 TNQLMETLKTIKKENIQQK---AQLDSFVKSMSSLQNDRDRIVGDYQQLEE--RHLSIIL 2492

Query: 1615 EKAKTHYDAKKQQNQELQEQLRSL----EQLQKENKELRAEAERLGHELQQA-GLKTKEA 1669
            EK +   +A   +N +L+E++R L    + L  EN +L AE  +   +L Q   +K  + 
Sbjct: 2493 EKDQLIQEA-AAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQ 2551

Query: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSC 1729
            +Q       Q + LE + A  +++L++  +         +   + K  L   I+SL +S 
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611

Query: 1730 EEGTPLSITSKLPRTQPDGT 1749
             +     +T ++   Q +GT
Sbjct: 2612 SQ-----LTRQVTALQEEGT 2626



 Score =  216 bits (551), Expect = 1e-55
 Identities = 394/1845 (21%), Positives = 750/1845 (40%), Gaps = 227/1845 (12%)

Query: 147  LENFLQKAPVPSTCSSTFP---EELSPPSHQAK--REIRFLE--LQKVASSSSGNNFLSG 199
            LE+  Q  P+     S+ P   +E +   HQ++   EI   +  ++  ++   G+  LS 
Sbjct: 615  LEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSA 674

Query: 200  SPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRID 259
             P     DI Q  Q ++ RLK Q+ +   N  + + E+ E  K L EK  +I+ + Q I+
Sbjct: 675  VP-----DIGQCHQDELERLKSQILELELNFHKAQ-EIYE--KNLDEKAKEISNLNQLIE 726

Query: 260  RL-----------ALLNEKQAASPLEPKELE---ELRDKNESLTMRL------------- 292
                           L+E++     + KEL    ELR + + L M L             
Sbjct: 727  EFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYES 786

Query: 293  ---HETL--KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEE 347
               H+ L  +Q   L  E    D KI  L  E  D+  +  E ++ ++ LQ  L     E
Sbjct: 787  QTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846

Query: 348  ---------HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
                     H  +  E L  QA  +KEL     D+  LE+K ++         E L Q  
Sbjct: 847  VLEGAERVRHISSKVEELS-QALSQKELEITKMDQLLLEKKRDV---------ETLQQTI 896

Query: 399  DNPPQEKGEVLGDVLQ-LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 457
            +   Q+  E+   + + +  L +E  +L      L+ ++ +L      ++ ++       
Sbjct: 897  EEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQV------- 949

Query: 458  EEEKQQLSSLITDLQSSISNLSQ-AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ 516
             EE  ++SS +      +S   Q +KEEL+            +   L + L      +Q+
Sbjct: 950  -EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQR 1008

Query: 517  Q---DQELAGLKQQAKEKQAQLAQTLQQQ-EQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
                ++ELA LK ++K K+  L++T + + E+  +   +  + ++S  ++ E  LK+   
Sbjct: 1009 VSRLEEELANLKDESK-KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS 1067

Query: 573  KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
            ++E   Q   + L    EE+ A+  +  A +KQ+    ++K  ++++LQ ++        
Sbjct: 1068 EKEVELQHIRKDL----EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQ 1123

Query: 633  SAQTSVTQAQR--EKAELSRKVEELQACVETARQEQHEAQAQVAELEL---QLRSEQQKA 687
               TS T A      A +   V     C  ++   + E + ++  LE    QL+ + Q+A
Sbjct: 1124 KLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA 1183

Query: 688  TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRC---ISELKAETR 744
                +   +K   QE+ + L+E LK  K      + +  +  +E +     + +L+ + R
Sbjct: 1184 LTSRKAILKK--AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241

Query: 745  SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
              ++  K    + +E  +   GLE  L +  E H  +  VL   L     + H+ ++   
Sbjct: 1242 ESIDG-KLPSTDQQESCSSTPGLEEPLFKATEQHHTQP-VLESNLCPDWPS-HSEDASAL 1298

Query: 805  QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE 864
            Q    VA  + + ++ + E+ +           L ++ E+  Q LQE   K  G+E  S 
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQ-LQEQINK-QGLEIESL 1356

Query: 865  LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
              +S +    AE+HA    +LQQ  E         + L  LQ K+         L+ L+ 
Sbjct: 1357 KTVSHE----AEVHAE---SLQQKLESSQLQIAGLEHLRELQPKLD-------ELQKLIS 1402

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
            K  E     S +L ++ A     Q E +E++   +   TQ  +QA E +       +++L
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD-----ERIKQL 1457

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
            +  L E + Q+ EE G++ R   ++ +   + QA L   K A  E    LQ  L+  R  
Sbjct: 1458 QVELCEMK-QKPEEIGEESRAKQQIQR---KLQAALISRKEALKE-NKSLQEELSLARGT 1512

Query: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASG 1104
               L ++LA   ++   +++E   + G  A   +E ++L   + ++   L + +   +S 
Sbjct: 1513 IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL---ITEMDRSLLENQSLSSSC 1569

Query: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL 1164
               +    G TE     ++ + +  S    +  + QE+   L++  E    S     +  
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1629

Query: 1165 ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKN 1224
            E +Q  +E   QE       L S +        ++Q+   AE E +    + R+ A+ K 
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE---AEQEMEEMKEKMRKFAKSKQ 1686

Query: 1225 SLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
              I  LEEE   L  +V      +KE    +++ +   ++  ER+++     +       
Sbjct: 1687 QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLM 1746

Query: 1285 ERSSALREEVQSLREEAEKQRVASENLR--QELTSQAERAEELGQELKAWQEKFFQKEQA 1342
                +L EEVQ L+ + E       NL   ++  +Q    EE  Q +    E+    + +
Sbjct: 1747 SEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE----QDS 1802

Query: 1343 LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE---KRHREELEQSKQAAGGLRAE- 1398
            LS       ST+   SE +P+        ++  ++      + ++++Q K+   GL  E 
Sbjct: 1803 LSM------STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856

Query: 1399 -----------------LLRAQRELGELIPLRQKVAEQERTAQQLRAE--------KASY 1433
                             L +   + GEL  L+++V +     QQ++ E        + + 
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916

Query: 1434 AEQLSMLKKAHGLLAEENRGLGER------ANLGRQFLEVE----------LDQAREKYV 1477
             E+  + ++    LAE N  +G        A +  + LE E          L++ +++ V
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976

Query: 1478 QELAAVRADAETRLAEVQREAQ------STARELEVMTAKYEGAKVKVLEERQRFQEERQ 1531
            +E   V ++      E  + AQ      S A+EL+ +  + +    ++ ++  R+QE+  
Sbjct: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKIS 2036

Query: 1532 KLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQA 1591
             L   V+ LE  Q E  K +E   + LA + +  K  Q +L + +    ++Q EA R+ A
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA 2096

Query: 1592 QLNELQAQL--------SQKEQAAEHYKLQMEKAKT-HYDAKKQQNQELQEQLRSLEQLQ 1642
               +L+ +L        SQ +Q  E  + ++E+A+  H   KK   ++L    R    L+
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156

Query: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQV 1702
            +   E++    +   E+QQ     +  + T   L A  +S+ +     D+ + +  K++ 
Sbjct: 2157 ETIGEIQVTLNKKDKEVQQL---QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213

Query: 1703 A-TDALKSREPQAK-------------PQLDLSIDSLDLSCEE-GTPLSITSKLPRTQPD 1747
              +DA++S+E + +              Q+ + ++ L ++         I     +T+  
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ 2273

Query: 1748 GTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSA 1807
                  +     ++ L  ++E    LY +       A LES L SL D   D        
Sbjct: 2274 LQQKVCDTLQGENKELLSQLEETRHLYHSS--QNELAKLESELKSLKDQLTDLSNSLEKC 2331

Query: 1808 RRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATS 1852
            + +   +  I   ++ D++     NS F   +     QAS   TS
Sbjct: 2332 KEQKGNLEGIIRQQEADIQ-----NSKFSYEQLETDLQASRELTS 2371



 Score =  205 bits (521), Expect = 4e-52
 Identities = 346/1700 (20%), Positives = 702/1700 (41%), Gaps = 233/1700 (13%)

Query: 207  DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
            DI++    Q+++  + L +ER   D       + +KL     A++  + + I+ +    +
Sbjct: 66   DIIRQKDVQLQQKDEALQEERKAADN------KIKKLKLHAKAKLTSLNKYIEEMKA--Q 117

Query: 267  KQAASPLEPKELEELRDKNESLT---MRLHETLKQCQDLKTEKSQMDRKINQL-SEENGD 322
                 P EP+  E+L   ++S T   M + +   + Q+ +   S +  ++ Q  +E+   
Sbjct: 118  GGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQ 177

Query: 323  LSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ-LEKELSAALQDKKCLEEKNE 381
             S ++ EF    QQLQ+    ++   ++ +Q   E+ AQ + +E  A  + +  L E +E
Sbjct: 178  SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE-DE 236

Query: 382  ILQ-----GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARV 436
            +LQ        +++++ L  LQ    + +  ++G    ++ L+QE       N  L  ++
Sbjct: 237  LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296

Query: 437  EMLETERG---------QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL-------SQ 480
            + +E E           ++E+K+L E+   E  +++LS    +LQ  + +L        Q
Sbjct: 297  QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS--FHNLQEEMHHLLEQFEQAGQ 354

Query: 481  AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ-------AKEKQA 533
            A+ ELE    A   +  A++   TS + +L  T Q+       LK Q         E+  
Sbjct: 355  AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414

Query: 534  QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
            Q AQT+QQ E     L+ + +++S  L +   Q  E A  Q +    + +      EE  
Sbjct: 415  QSAQTIQQLEDQ---LQQKSKEISQFLNRLPLQQHETA-SQTSFPDVYNEGTQAVTEENI 470

Query: 594  ASLRERDAALKQLEALEKEKAAKL--EILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
            ASL+      K++  LE EK A L   I  ++L+  NE + S+Q ++ +AQ    E  R+
Sbjct: 471  ASLQ------KRVVELENEKGALLLSSIELEELKAENE-KLSSQITLLEAQNRTGEADRE 523

Query: 652  VEEL-----------------QACVETARQEQH-----------EAQAQVAELELQLRSE 683
            V E+                 Q  +E    ++H           EAQ ++A L+LQL+ +
Sbjct: 524  VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583

Query: 684  QQKATEKERVAQEKDQLQEQLQALKESLKV------TKGSLEEEKRRAADALEEQQRCIS 737
            + +  + E + Q++ +  E        +KV          L   +  +  A+E++Q   +
Sbjct: 584  RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ-AST 642

Query: 738  ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEA----M 793
            E ++ T   +  +    +    ++ G K L A +  +G+ HQ E E L+ ++ E      
Sbjct: 643  EHQSRTSEEISLNDAGVELKSTKQDGDKSLSA-VPDIGQCHQDELERLKSQILELELNFH 701

Query: 794  AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMF------QEQLMTLKEECE---K 844
             AQ   E   ++  KE++   +  E+ ++      + F      ++QL++  +E     +
Sbjct: 702  KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE 761

Query: 845  ARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLST 904
             R ++++ +  +A  E    L    Q      L   +     + + K+V+ + L ++L  
Sbjct: 762  LRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDD 821

Query: 905  LQEKMAATSKEVARLET-LVRKAGEQQETASR-----ELVKEPARAGDRQPEWLEEQQGR 958
            +Q + +  S  +  L++ L  K  E  E A R       V+E ++A   Q E    +  +
Sbjct: 822  VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS-QKELEITKMDQ 880

Query: 959  QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE---RGR 1015
                 +  ++ +++  E+   ++  +  ++ E   Q  EE+     E+  L ++     R
Sbjct: 881  LLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR 940

Query: 1016 AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHA--LTEKEGKDQELAKLRGLE 1073
            A+     +     E+   L+   +E        +E L H   L +KE + ++    R L+
Sbjct: 941  AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK----RKLQ 996

Query: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK-- 1131
            AA I   +EL Q V +L+E+LA  + E            G  E      E     V+   
Sbjct: 997  AALINR-KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKC 1055

Query: 1132 ------LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
                  L+Q   +++ +   + + LE + A+  +  + ++ +   L++K  ++   Q+ +
Sbjct: 1056 QEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEI 1115

Query: 1186 ASAQ---RELAAFRTKVQD----------------------HSKAE--------DEWKAQ 1212
            +  Q   ++L    T   D                      H K E        ++ K Q
Sbjct: 1116 SENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQ 1175

Query: 1213 VARGRQEA-ERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271
            + +  QEA   + +++   +E+   L  ++ +++ +   L+     +S++++ + ++LR 
Sbjct: 1176 LQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ 1235

Query: 1272 LQAET---------ASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERA 1322
            LQ +          +++   +   +  L E +    E+   Q V   NL  +  S +E A
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295

Query: 1323 EELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA---------- 1372
              L       Q K   KE     ++LE     +  SEL        QLQ           
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELE-LKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354

Query: 1373 -------EQAAAEKRHREELEQSKQAAGGLR--AELLRAQRELGELIPLRQ--------K 1415
                   E     +  +++LE S+    GL    EL     EL +LI  ++        +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414

Query: 1416 VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREK 1475
            ++E+E    +++ E     EQ  ++K  H  L  + +   ER     + L+VEL + ++K
Sbjct: 1415 LSEKEAALTKIQTE---IIEQEDLIKALHTQLEMQAKEHDERI----KQLQVELCEMKQK 1467

Query: 1476 --YVQELAAVRADAETRL-------AEVQREAQSTARELEVMTAKYEGAKVKVLEERQRF 1526
               + E +  +   + +L        E  +E +S   EL +     E     + +   + 
Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527

Query: 1527 QEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS--------------KVQQQKL 1572
              + ++    + +L + Q E+ K + E+ + L ++   S              + +++ +
Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587

Query: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
            K +++       E+   Q +  ELQ +     Q+ E+   + E+ +   +A +Q+ QEL 
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647

Query: 1633 EQLRSLEQLQKENKELRAEAERLGHELQQAGLK-TKEAEQTCRHLTAQVRSLEAQVAHAD 1691
             +LRS E  +KE ++   EAE+   E+++   K  K  +Q    L  +   L A+V  A 
Sbjct: 1648 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAG 1707

Query: 1692 QQLRDLGKFQVATDALKSRE 1711
               ++  +  ++++A    E
Sbjct: 1708 DTAKECMETLLSSNASMKEE 1727



 Score =  197 bits (502), Expect = 7e-50
 Identities = 340/1681 (20%), Positives = 700/1681 (41%), Gaps = 229/1681 (13%)

Query: 92   ELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLE-NF 150
            EL LA+ T+  L  S    +S     Q   + + +  V+ +  L  E+   L  +++ + 
Sbjct: 1505 ELSLARGTIERLTKSLADVES-----QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL 1559

Query: 151  LQKAPVPSTCSST--FPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDI 208
            L+   + S+C S     E L+    +  +EI  L+  K+A S+               +I
Sbjct: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--KHKELQKEYEI 1617

Query: 209  L----QTPQFQMRRLKKQLADERSNRDEL--ELELAENRKLLTEKDAQIAMMQQRIDRLA 262
            L    +    +  R++  +   R  + EL  +L   E  K  TEK  Q A  +Q ++ + 
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA--EQEMEEMK 1675

Query: 263  LLNEKQAASPLEPKELEELRDKNESLTMRLH---ETLKQCQD-LKTEKSQMDRKINQLSE 318
                K A S  + +++ EL ++N+ L   +H   +T K+C + L +  + M  ++ ++  
Sbjct: 1676 EKMRKFAKS--KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733

Query: 319  ENGDLSFKLREFASHLQQLQDALNELTE--EHSKATQEWLEKQAQLEKELSAALQDKKCL 376
            E   LS K +   S    L + + +L    E + + Q  LE   + + + +   +  + +
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793

Query: 377  ----EEKNEILQGKLSQLEEHLSQLQD-NPPQEKG-----EVLGDVLQLETLKQEAATLA 426
                EE++ +         E +   +  NP   K      E+   + Q++ LK+  A L 
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853

Query: 427  ANNTQLQARVEMLETERGQQEAKLLAERGHF---EEEKQQLSSLITDLQSSISNLSQAKE 483
                + +   + LE E+    +++  + G     +EE  +++ L   +Q  +S +++ KE
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913

Query: 484  ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
              E+       RL  Q+A L       N +I    Q++           AQ+   L + E
Sbjct: 1914 TAEEEKDDLEERLMNQLAEL-------NGSIGNYCQDVT---------DAQIKNELLESE 1957

Query: 544  QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL 603
               + L+  V +L    ++K+Q +KE  + +   R+++ +++  A +E         +  
Sbjct: 1958 M--KNLKKCVSELE---EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPG-----NKSHA 2007

Query: 604  KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663
            K+L+ L KEK  +++ LQ+      E   + + +V   +  + E  + +E  +  +  A 
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067

Query: 664  QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
            + + +AQA++A  ++ L   Q +A    RV  +  +L+++LQ+ KES+K      +E+  
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAA---RVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124

Query: 724  RAADALEEQQRCISELKAETRSLVEQHKRERKELEEE----RAGRKGLEARLQQLGEAHQ 779
            R  +  EE+     + K   +  ++  +RE+  LEE     +      +  +QQL    Q
Sbjct: 2125 RRLEQAEEKHL---KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL----Q 2177

Query: 780  AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK 839
               +    +LA    +  + + + ++++ E   W  ++ D+ Q + +   + ++    LK
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLK 2237

Query: 840  EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899
            ++  +    ++E K  ++ +E   ++  S+ Q E+ +L   +   LQ  + KE+ +Q   
Sbjct: 2238 DQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV-QLQQKVCDTLQG-ENKELLSQ--- 2292

Query: 900  DDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQ 959
              L   +    ++  E+A+LE+ ++   +Q    S  L K   + G+   E +  QQ   
Sbjct: 2293 --LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL--EGIIRQQ--- 2345

Query: 960  FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD 1019
                +A +Q  +   EQ+  +L+  R    E   +  EE   +E+++  L   +  A   
Sbjct: 2346 ----EADIQNSKFSYEQLETDLQASR----ELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397

Query: 1020 LALEKAARAELEMR-LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078
               E   + + E++ L+N L+++  E   L+E    A+ +    +Q +  L+ ++   I+
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKT---NQLMETLKTIKKENIQ 2454

Query: 1079 ELEELRQTVKQLK-------------EQLAKK------EKEHASGSGAQSEAAGRTEPTG 1119
            +  +L   VK +              +QL ++      EK+      A      + E  G
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG 2514

Query: 1120 PK--LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE----RDSALETLQGQLEE 1173
             +  ++ L +E +KL+ +  + +E  + +    ++++    E    ++  LE    +LEE
Sbjct: 2515 LRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574

Query: 1174 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK----------------------- 1210
            K +E   S+ A    +R   A + + QD SK  +  K                       
Sbjct: 2575 KLKE---SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631

Query: 1211 AQVARGRQEAERKNSLISS-------LEEEVSILNRQVLEKEGE-----SKELKRL---- 1254
            AQ+    +E  R ++L SS       LEEE+  + ++  +K GE      KELK L    
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691

Query: 1255 --VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLR 1312
              +  E+E +++    L     E         + +  L  ++QS        + + ++  
Sbjct: 2692 GIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751

Query: 1313 QELTSQAERAEELGQELKAWQEKFF---QKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369
            +EL     + +   +EL   +E+     +++  LS       ST+   + L   + L QQ
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEE--NSLSHLEKLNQQ 2809

Query: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAE 1429
            L ++          +LE S          +   Q E   L    +K  + E   Q+  A+
Sbjct: 2810 LLSKDEQL-LHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQ 2868

Query: 1430 KASYAEQLSMLKKAHGLLAEE-NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488
             ++   ++  LKKA   L  + +R L E  NL +Q+L++  +      + EL  ++A  +
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE------ITELHPLKAQLQ 2922

Query: 1489 TRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR--- 1545
                    E Q   +  ++M       + ++ +E   +Q E  +L  +    E+ +R   
Sbjct: 2923 --------EYQDKTKAFQIM-------QEELRQENLSWQHELHQLRMEKSSWEIHERRMK 2967

Query: 1546 -----------EQTKQVEELSKKLADSD---QASKVQQQKLKAVQAQGGESQQ-----EA 1586
                       +Q   ++ L ++L  S    Q  KVQ Q+  + +             E 
Sbjct: 2968 EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYET 3027

Query: 1587 QRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK 1646
            + L+ QLN+   ++ QKE       L++++  +++    ++   L  QL    Q  +EN+
Sbjct: 3028 ELLRTQLNDSLKEIHQKE-------LRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQ 3080

Query: 1647 E 1647
            +
Sbjct: 3081 Q 3081



 Score =  173 bits (439), Expect = 1e-42
 Identities = 320/1522 (21%), Positives = 634/1522 (41%), Gaps = 224/1522 (14%)

Query: 79   ECLVSAQKVLEGSELELAKM---TMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVL 135
            E L+S+   ++  ELE  KM   T+   + S MS K     E  + K Q E  V  +  L
Sbjct: 1715 ETLLSSNASMK-EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANL 1773

Query: 136  D----HEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSS 191
            +    H++  N+ E+     Q  P  +    +      P   ++           V S+ 
Sbjct: 1774 EATEKHDNQTNVTEE---GTQSIPGETEEQDSLSMSTRPTCSES-----------VPSAK 1819

Query: 192  SGNNFLSGSPASPMGDILQTPQFQMRRLKKQLA--DERSNRDELELELAENRK-----LL 244
            S N  +S   +S   D +     Q+ +LK+++A  +E   +++   +  EN K      +
Sbjct: 1820 SANPAVSKDFSSH--DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQI 1877

Query: 245  TEKDAQIAMMQQRIDRLALLNEK-----QAASPLEPKELEELRDKNESLTMRLHETL--- 296
            + KD ++ M+Q+ + ++ LLN++        + L+    EE  D  E L  +L E     
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937

Query: 297  -KQCQD----------LKTEKSQMDRKINQLSEENGDLSFKLREFAS-----HLQQLQDA 340
               CQD          L++E   + + +++L EE   L  +  +  S     +L+++Q A
Sbjct: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGA 1997

Query: 341  LNEL-TEEHSKATQEWLEKQAQLEKEL-----------SAALQDKKCLEEKNEILQGKLS 388
              E   + H+K  QE L+++ Q  K+L           SA  +  K LE      Q  L 
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE 2057

Query: 389  QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANN---------------TQLQ 433
              +E+L+Q  ++  + + E+    + L+  + EAA + A+N               +Q++
Sbjct: 2058 ITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK 2117

Query: 434  ARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN----LSQAKEELEQAS 489
             + E LE    Q E K L E+ + +E+   L      L+ +I      L++  +E++Q  
Sbjct: 2118 QKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQ 2177

Query: 490  QAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL 549
            +   + +T Q+A+ T  +++L     Q D++   +  +AK+ + + +  +Q +E+  +  
Sbjct: 2178 ENLDSTVT-QLAAFTKSMSSL-----QDDRDR--VIDEAKKWERKFSDAIQSKEEEIRLK 2229

Query: 550  RHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEAL 609
                  L   L+Q    ++E+  K   +R +H +Q+  +  + E  L+++     Q E  
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEEL--KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287

Query: 610  EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
            E         L  QL+       S+Q  + + + E   L  ++ +L   +E  ++++   
Sbjct: 2288 E---------LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338

Query: 670  QAQVAELELQLR----SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA 725
            +  + + E  ++    S +Q  T+ +   +   +L E++  +KE   ++  S +EE  + 
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEIN-MKEQKIISLLSGKEEAIQV 2397

Query: 726  ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785
            A A E +Q+   E+K E  +L+ Q + E   LEEE         +L +  +  + E    
Sbjct: 2398 AIA-ELRQQHDKEIK-ELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ 2455

Query: 786  RRELAEAMAAQHTAESECEQLVKEVAAWRERY-----EDSQ--QEEAQYGAMFQEQLMTL 838
            + +L   + +  + +++ +++V +     ER+     E  Q  QE A      +E++  L
Sbjct: 2456 KAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGL 2515

Query: 839  KEECEKARQE----------LQEAKEKVAGIESHSE---LQISRQQNELAELHANLARAL 885
            +   +    E           +E   +V  I+   +   L++  QQN+  EL    A+  
Sbjct: 2516 RSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK--ELENKYAKLE 2573

Query: 886  QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG 945
            ++++E E   + L    + LQE+    SKE+  L+  + +   Q      E       A 
Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633

Query: 946  DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQERE 1005
             +  E    +    F S+Q  +  +E E          L     E+  +  E   + ++E
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEE----------LVCVQKEAAKKVGEIEDKLKKE 2683

Query: 1006 VARLTQERG--RAQADLALEKAAR-----AELEMRLQNALNEQRVEFATLQE---ALAHA 1055
            +  L  + G  R + + A E+ A       E+E +L     E +   A +Q    +++  
Sbjct: 2684 LKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743

Query: 1056 LTEKEGKDQELAKLRGLEAAQIKELEELRQT----------------------------V 1087
               ++  ++EL +L+    A +KEL +L++                             +
Sbjct: 2744 QNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHL 2803

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            ++L +QL  K+++    S    ++  + +     + +L+ E   L  + +K ++  +  +
Sbjct: 2804 EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQ 2863

Query: 1148 RSLEAERASRAERDS---ALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1204
            RS      S AE  S   A+ +LQ   +   +EL + Q       +E+           +
Sbjct: 2864 RSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQE 2923

Query: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK-RLVMAESEKSQ 1263
             +D+ KA   +  QE  R+ +L  S + E+  L  +    E   + +K + +MA S+K Q
Sbjct: 2924 YQDKTKA--FQIMQEELRQENL--SWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQ 2979

Query: 1264 KLEERLRLLQAETASNS----------ARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313
            +L     L++   +S+S           +A+  +SA  +  Q+L  E E  R    +  +
Sbjct: 2980 QLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLK 3039

Query: 1314 ELTSQAERAEELGQEL-KAWQEKFFQKEQALSTLQLEHTSTQ---ALVSELLPAKHLCQQ 1369
            E+  +  R ++L     +  +EK     Q   T Q    + Q    L++     +   Q+
Sbjct: 3040 EIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQE 3099

Query: 1370 LQA--------------EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415
            LQA              +     K   EEL + +Q+    + +L   ++E+ EL    +K
Sbjct: 3100 LQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNEL----RK 3155

Query: 1416 VAEQERTAQQLRAEKA-SYAEQ 1436
            + E+ER  Q++ AE A S AE+
Sbjct: 3156 LLEEERD-QRVAAENALSVAEE 3176



 Score =  168 bits (426), Expect = 5e-41
 Identities = 296/1431 (20%), Positives = 574/1431 (40%), Gaps = 214/1431 (14%)

Query: 458  EEEKQQLSSLITDLQSSISN----LSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
            +E       L+ +L+  I      L Q  E L++  +A   ++        ++LT+LN  
Sbjct: 51   QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110

Query: 514  IQQ---QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQV---EQLSSSLKQKEQQL 567
            I++   Q   +   + Q++E+ ++  ++  ++E   + ++H++   E+L S+L+ +  Q 
Sbjct: 111  IEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170

Query: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
            +     Q +T  +    +    +E+E  +    A L Q +A   E+AA+  + ++  +  
Sbjct: 171  QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA---EQAAQQVVREKDARFE 227

Query: 628  NEAR---DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
             + R   D     VTQA  E  E+ +K+  LQ  +E   +E    +AQV +L       Q
Sbjct: 228  TQVRLHEDELLQLVTQADVE-TEMQQKLRVLQRKLEE-HEESLVGRAQVVDLL------Q 279

Query: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
            Q+ T  E   Q    L +QLQ ++      + ++E E+  +   LE+ +  ++E K    
Sbjct: 280  QELTAAE---QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336

Query: 745  SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
            +L E+     ++ E+    +  LE+R   L + H+AE E     +          +S C+
Sbjct: 337  NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACD 396

Query: 805  QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA------- 857
             L  + +   +   +   + AQ     ++QL    +E  +    L   + + A       
Sbjct: 397  ALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD 456

Query: 858  ----GIESHSELQISRQQNELAEL-HANLARALQQVQEKEVRA--QKLADDLSTL--QEK 908
                G ++ +E  I+  Q  + EL +   A  L  ++ +E++A  +KL+  ++ L  Q +
Sbjct: 457  VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNR 516

Query: 909  MAATSKEVARLE---------------------------------TLVRKAGEQQETASR 935
                 +EV+ +                                   L+     Q+E A  
Sbjct: 517  TGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL 576

Query: 936  ELVKEPARAGDRQPEWLEEQQGRQF-------CSTQAALQAMEREAEQMGNELERLRAAL 988
            +L  +  RA +   E L++++ +Q           +  L+   ++   M NE   L A  
Sbjct: 577  KLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVE 636

Query: 989  MESQGQQQEERGQQEREV--ARLTQERGRAQADLALE------KAARAELEMRLQNALNE 1040
             E    + + R  +E  +  A +  +  +   D +L       +  + ELE RL++ + E
Sbjct: 637  KEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE-RLKSQILE 695

Query: 1041 QRVEFATLQEALAHALTEKEGKDQELAKL---------------------RGLEAAQIKE 1079
              + F   QE     L EK  +   L +L                     R    +Q+KE
Sbjct: 696  LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755

Query: 1080 LE---ELRQTVKQLKEQLAKKEKEHASGSGAQS-----------EAAGRTEPTGPKLEAL 1125
            L    ELR  VKQL+  LA+ E++      +Q+             +   +    K+E L
Sbjct: 756  LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815

Query: 1126 RAEVSKLEQQCQKQQEQADSLERSL---EAERASRAER----DSALETLQGQLEEKAQEL 1178
            + E+  ++ Q  +Q     SL+  L   E+E    AER     S +E L   L +K  E+
Sbjct: 816  QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEI 875

Query: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWK-AQVARGRQEAERKNSL---ISSLEEEV 1234
                  L   +R++   +  +++  +   E   +   +  Q  E K SL   I +L+E++
Sbjct: 876  TKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL 935

Query: 1235 SILNR-------QVLEKEGESKELKRLVMAESEKSQ---------------KLEERLRLL 1272
            ++L+R       QV E    S  LK+     S   Q               + E+R R L
Sbjct: 936  NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKL 995

Query: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAW 1332
            QA    N     +R S L EE+ +L++E++K+   SE  R E+    E  E         
Sbjct: 996  QA-ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKE--------- 1045

Query: 1333 QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA 1392
               + +K       ++E    Q +  + +  +H+ + L+ E+ AAE++ +  ++Q  Q  
Sbjct: 1046 ---YSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLE-EKLAAEEQFQALVKQMNQT- 1100

Query: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
                      Q +  ++  L+ +++E +   Q+L       ++  S+       L +E  
Sbjct: 1101 ---------LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV------ALVKETV 1145

Query: 1453 GLGERANLGRQFLEVELDQ---AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMT 1509
             +        +  + EL++   A EK  ++L     +A T    + ++AQ   R L    
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREEL 1205

Query: 1510 AKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE-------QTKQVEELSKKLADSD 1562
             + +    ++ E+     +E + +  Q+ QL++  RE        T Q E  S      +
Sbjct: 1206 KQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEE 1265

Query: 1563 QASKVQQQKLKAVQAQGG------ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEK 1616
               K  +Q       +           ++A  LQ   +  Q +   KE  AE  +L+++ 
Sbjct: 1266 PLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV 1325

Query: 1617 AKTHYDAKKQQNQ--ELQEQLR----SLEQLQKENKELRAEAERLGHELQQAGLKTKEAE 1670
            + T  +  K+  +  +LQEQ+      +E L+  + E    AE L  +L+ + L+    E
Sbjct: 1326 SSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE 1385

Query: 1671 QTCRHLTAQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQAKPQLDL 1720
               R L  ++  L+  ++  ++ +  L G+      AL   + +   Q DL
Sbjct: 1386 H-LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435



 Score =  154 bits (388), Expect = 1e-36
 Identities = 255/1203 (21%), Positives = 502/1203 (41%), Gaps = 179/1203 (14%)

Query: 220  KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE 279
            K+ LA    +R + + ELA  + LL +  ++ A +    D L L  E Q+    +     
Sbjct: 2060 KENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA--DNLKLKKELQSN---KESVKS 2114

Query: 280  ELRDKNESLTMRLHET----LKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
            +++ K+E L  RL +     LK+ ++++ +   + R+   L E  G++   L +    +Q
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174

Query: 336  QLQDALNELTEEHSKATQEW----------LEKQAQLEKELSAALQDK----KCLEEKNE 381
            QLQ+ L+    + +  T+            +++  + E++ S A+Q K    +  E+   
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234

Query: 382  ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLET 441
            +L+ +L Q+  H+ +L+ N           + +LE  KQ   + A    QLQ +V   +T
Sbjct: 2235 VLKDQLRQMSIHMEELKIN-----------ISRLEHDKQIWESKAQTEVQLQQKV--CDT 2281

Query: 442  ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVA 501
             +G              E K+ LS L            +    L  +SQ   A+L +++ 
Sbjct: 2282 LQG--------------ENKELLSQL------------EETRHLYHSSQNELAKLESELK 2315

Query: 502  SLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK 561
            SL  +LT L+ ++++            KE++  L   ++QQE   Q  +   EQL + L+
Sbjct: 2316 SLKDQLTDLSNSLEK-----------CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364

Query: 562  QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE----RDAALKQLEALEKEKAAKL 617
               +    + E+     Q     L+   E  + ++ E     D  +K+LE L  ++  + 
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424

Query: 618  EILQQQLQVA----NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV 673
             +L+++ + A    N+  ++ +T   +  ++KA+L   V+ + + ++  R        Q+
Sbjct: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSS-LQNDRDRIVGDYQQL 2483

Query: 674  AELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ 733
             E  L +  E+ +  ++   A E ++L+E+++ L+  +        +         E+  
Sbjct: 2484 EERHLSIILEKDQLIQE--AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541

Query: 734  RCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAM 793
            + I+   ++ + L+E   ++ KELE + A    LE +L++  EA+    E LRR      
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAK---LEEKLKESEEAN----EDLRRSFNALQ 2594

Query: 794  AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK-------AR 846
              +     E E L   ++    R   + QEE   G ++  QL   +EE  +       ++
Sbjct: 2595 EEKQDLSKEIESLKVSISQLT-RQVTALQEEGTLG-LYHAQLKVKEEEVHRLSALFSSSQ 2652

Query: 847  QELQEAKEKVAGIESHSELQIS----RQQNELAELHANLARALQQVQEKEVRAQKLADDL 902
            + + E +E++  ++  +  ++     + + EL  LH +      + +  E R  +LA DL
Sbjct: 2653 KRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDL 2712

Query: 903  STLQEKMAATSKEVARLETLVRKAGEQQET-------ASREL--VKEPARAGDRQPEWLE 953
              +++K+   +KE   L   ++  G    +       A+ EL  +K    A  ++   L+
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772

Query: 954  EQ----QGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARL 1009
            EQ    + R    ++ A  +M    E   + LE+L   L+ S+ +Q      Q  +    
Sbjct: 2773 EQGLLNRERDALLSETAF-SMNSTEENSLSHLEKLNQQLL-SKDEQLLHLSSQLEDSYNQ 2830

Query: 1010 TQERGRAQADLALEKAAR-AELEMRLQNALNEQR---------VEFATLQEALAHALTEK 1059
             Q   +A A L  E+     ELE   ++   +QR          E  +L++A++    ++
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR 2890

Query: 1060 EGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
               D+ L +L+ L+   ++  +E+ + +  LK QL + + +  +    Q E         
Sbjct: 2891 ---DRLLKELKNLQQQYLQINQEITE-LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ 2946

Query: 1120 PKLEALRAEVSKLEQQCQKQQEQ-----ADSLERSLEAERASRAERDSALET--LQGQLE 1172
             +L  LR E S  E   ++ +EQ     +D  ++    +   R  R S+ +T  L+ Q +
Sbjct: 2947 HELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006

Query: 1173 EKAQ-ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLE 1231
             +A  E   S     +   E    RT++ D  K       ++ +     ++ NS  S L 
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLK-------EIHQKELRIQQLNSNFSQLL 3059

Query: 1232 EEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQA----------------- 1274
            EE + L+ Q+ +     +E ++           LE++++ LQA                 
Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119

Query: 1275 -----------ETASNSARAAERSSALREEVQSLR---EEAEKQRVASENLRQELTSQAE 1320
                       E   + + A ++    R+EV  LR   EE   QRVA+EN       Q  
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179

Query: 1321 RAE 1323
            R E
Sbjct: 3180 RLE 3182



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 171/832 (20%), Positives = 335/832 (40%), Gaps = 175/832 (21%)

Query: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA------------ 1095
            L   + H L+  +  DQ +      E  Q  ++E    T + ++E+LA            
Sbjct: 8    LANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDI 67

Query: 1096 --------------------------KKEKEHASGS--------GAQSEAAGRTEPTGPK 1121
                                      KK K HA                  G   PT P+
Sbjct: 68   IRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127

Query: 1122 LEAL-----------RAEVSKLEQQCQKQQEQADSLERSL-EAERASRAERDSALE---T 1166
             E               E+ K++ + Q+++E   +L+  L +A+    A+  + +E    
Sbjct: 128  SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM 187

Query: 1167 LQGQLEEKAQELGHSQSALASAQRELAA----------FRTKVQDHSKAEDEWKAQVARG 1216
            ++ QL+EK + +   Q+ L+  Q E AA          F T+V+ H   EDE    V + 
Sbjct: 188  MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH---EDELLQLVTQA 244

Query: 1217 RQEAERKNSLISSLEEEVSILNRQVLEKE----GESKE---LKRLVMAESEKSQKLEERL 1269
              E E        +++++ +L R++ E E    G ++    L++ + A  +++Q L ++L
Sbjct: 245  DVETE--------MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296

Query: 1270 RLLQAE--TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ 1327
            + ++AE  T  N+       S +  E   L  E  +++++  NL++E+    E+ E+ GQ
Sbjct: 297  QQMEAEHNTLRNTVETEREESKILLEKMEL--EVAERKLSFHNLQEEMHHLLEQFEQAGQ 354

Query: 1328 ---ELKAWQEKFFQKEQALSTLQLEH-TSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
               EL++      QK +A    +  H  S Q    EL  A   C  L+ + +   +   E
Sbjct: 355  AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA---CDALKDQNSKLLQDKNE 411

Query: 1384 ELEQSKQAAGGLRAELLRAQRELGEL---IPLRQKVAEQERTAQQLRAE--KASYAEQLS 1438
            +  QS Q    L  +L +  +E+ +    +PL+Q     + +   +  E  +A   E ++
Sbjct: 412  QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIA 471

Query: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEV-ELDQAREKYVQELAAVRAD----------A 1487
             L+K   ++  EN    E+  L    +E+ EL    EK   ++  + A           +
Sbjct: 472  SLQKR--VVELEN----EKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVS 525

Query: 1488 ETRLAEVQREAQSTAREL------EVMTAKYEGAKVKVLEERQRFQE------ERQKLTA 1535
            E  + ++  +  S+A E          + K++   V +LE ++  +E      + Q   A
Sbjct: 526  EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRA 585

Query: 1536 QVEQLEVFQREQTKQVE-------ELSKKLADSDQASKV---QQQKLKAVQAQGGESQQE 1585
            +    EV  +++ KQ+E       ++   L D+ Q   +   ++  L AV+ +   ++ +
Sbjct: 586  EEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ 645

Query: 1586 AQRL-QAQLNELQAQLSQKEQAAEH-----------YKLQMEKAKTH--------YDAKK 1625
            ++   +  LN+   +L   +Q  +            ++ ++E+ K+         + A++
Sbjct: 646  SRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQE 705

Query: 1626 QQNQELQEQLRSLEQLQKENKELRAEAER-------LGHELQQAGLKTKEAEQTCRHLTA 1678
               + L E+ + +  L +  +E +  A+        L  E  Q   + KE       L A
Sbjct: 706  IYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV-TELRA 764

Query: 1679 QVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCE 1730
            QV+ LE  +A A++Q R   + Q A D L + +  +   L +   S D+  E
Sbjct: 765  QVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS---LSIEAKSKDVKIE 813



 Score = 61.6 bits (148), Expect = 8e-09
 Identities = 117/563 (20%), Positives = 226/563 (40%), Gaps = 123/563 (21%)

Query: 249  AQIAMMQQRIDRLALL---NEKQAASPLEP---------KELEELRDKNESLTMRLH--- 293
            AQ+ + ++ + RL+ L   ++K+ A   E          K++ E+ DK +     LH   
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691

Query: 294  -------ETLKQ-CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345
                   ET ++   +L  +  +M++K+  +++EN  L+ +++ F   +  LQ++ +   
Sbjct: 2692 GIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751

Query: 346  EEHSKATQEW---------LEKQAQLEKELSAALQDKKC------------LEEKNEILQ 384
            EE  +  +++         L++Q  L +E  A L +               LE+ N+ L 
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811

Query: 385  GKLSQLEEHLSQLQDNPPQ-------------EKGEVLGDVLQLETLKQEAATLAANNTQ 431
             K  QL    SQL+D+  Q             E+  +  ++ +    ++     AA  + 
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPST 2871

Query: 432  LQARVEMLETERGQQEA---KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
              A V+ L+      +    +LL E  + +++  Q++  IT+L    + L + +++ + A
Sbjct: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK-A 2930

Query: 489  SQAHGARLTAQVASLTSELTTLNA------------------TIQQQDQELAGLKQQAKE 530
             Q     L  +  S   EL  L                     I  +DQ+L+ L+   +E
Sbjct: 2931 FQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE 2990

Query: 531  KQAQLAQT----LQQQEQAS----------QGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576
             ++  +QT    +Q Q QAS          Q L ++ E L + L      LKE+ +K+  
Sbjct: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDS---LKEIHQKELR 3047

Query: 577  TRQ---------DHAQQLATAAEEREASLRERDA----ALKQLEALEKE----KAAKLEI 619
             +Q         +    L+    +   SLRE        L     LEK+    +A  L I
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107

Query: 620  -----LQQQLQVANEARD-----SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
                   Q+    +   D       Q S ++AQ++     ++V EL+  +E  R ++  A
Sbjct: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAA 3167

Query: 670  QAQVAELELQLRSEQQKATEKER 692
            +  ++  E Q+R  +    +  R
Sbjct: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  220 bits (560), Expect = 1e-56
 Identities = 265/1170 (22%), Positives = 518/1170 (44%), Gaps = 149/1170 (12%)

Query: 356  LEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
            L K A+ EKE++   ++   ++E  E  + +  +LEE +  L       + +V  +   L
Sbjct: 841  LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900

Query: 416  ETLKQEAATLAANNTQLQARV----EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDL 471
               ++    L  N  QL+A+V    E LE E  +  A+L A++   E+E  +L   I DL
Sbjct: 901  NDAEERCDQLIKNKIQLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDECSELKKDIDDL 959

Query: 472  QSSISNLSQAKEELEQASQ---AHGARLTAQVASLTSELTTLNATIQQ----------QD 518
            + +++ + + K   E   +      A L   +A LT E   L    QQ          + 
Sbjct: 960  ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKV 1019

Query: 519  QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
              L+  K + +++   L  +L+Q+++    L     +L   LK  ++ + ++ E  +   
Sbjct: 1020 NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL-ENDKLQL 1078

Query: 579  QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
            ++  ++      ++ + + +      QL+   KE  A++E L+++L+    AR   +   
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138

Query: 639  TQAQREKAELSRKVEEL--QACVETARQEQHEAQAQVAELELQLRSEQQKATE---KERV 693
            +   RE  E+S ++EE      V+    ++ EA+ Q    +L+  + Q +AT    +++ 
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198

Query: 694  AQEKDQLQEQ---LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
            A    +L EQ   LQ +K+ L+  K   + E       +E+  +  + L+  +R+L +Q 
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258

Query: 751  KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEV 810
               R +LEE +        +  +L    Q E   L R+L E        E+   QL +  
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKL----QTENGELARQLEE-------KEALISQLTRGK 1307

Query: 811  AAWRERYEDSQ---QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI 867
             ++ ++ ED +   +EE +        L + + +C+  R++ +E  E  A ++      +
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR----VL 1363

Query: 868  SRQQNELAELHANL-ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
            S+  +E+A+        A+Q+ +E E   +KLA  L   +E + A + + + LE    + 
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRL 1423

Query: 927  GEQQETASRELVKEPARAG-----DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
              + E    ++ +  A A       R  + +  +  +++  +Q+ L++ ++EA  +  EL
Sbjct: 1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483

Query: 982  ERLRAALMES----QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA 1037
             +L+ A  ES    +  ++E +  QE E++ LT++ G    ++   +  R +LE      
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQE-EISDLTEQLGEGGKNVHELEKVRKQLE------ 1536

Query: 1038 LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK 1097
                 VE   LQ AL  A    E ++ ++ + + LE  QIK          +++ +LA+K
Sbjct: 1537 -----VEKLELQSALEEAEASLEHEEGKILRAQ-LEFNQIK---------AEIERKLAEK 1581

Query: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
            ++E                               +EQ  +  Q   DSL+ SL+AE  SR
Sbjct: 1582 DEE-------------------------------MEQAKRNHQRVVDSLQTSLDAETRSR 1610

Query: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT-------KVQDHSKAEDEWK 1210
             E     + ++G L E   +L H+    A AQ+++ + ++       ++ D  +A D+ K
Sbjct: 1611 NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1670

Query: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
              +A      ER+N+L+ +  EE+    R V+E+   S++L    + E+       ER++
Sbjct: 1671 ENIA----IVERRNNLLQAELEEL----RAVVEQTERSRKLAEQELIET------SERVQ 1716

Query: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEEL--GQE 1328
            LL ++  S   +  +  S L +    + E  ++ R A E  ++ +T  A  AEEL   Q+
Sbjct: 1717 LLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1776

Query: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
              A  E+  +K    +   L+H   +A    L   K   Q+L+A     E     E +++
Sbjct: 1777 TSAHLER-MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRN 1835

Query: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
             ++  G+R    +++R + E   L  +  E ++   +L+       ++L +  KA+   A
Sbjct: 1836 AESVKGMR----KSERRIKE---LTYQTEEDKKNLLRLQ----DLVDKLQLKVKAYKRQA 1884

Query: 1449 EENRGLGERANLG-RQFLEV--ELDQAREK 1475
            EE     E+AN    +F +V  ELD+A E+
Sbjct: 1885 EEAE---EQANTNLSKFRKVQHELDEAEER 1911



 Score =  197 bits (500), Expect = 1e-49
 Identities = 258/1162 (22%), Positives = 518/1162 (44%), Gaps = 120/1162 (10%)

Query: 529  KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR--QDHAQQLA 586
            KE+  ++ +TL++ E   + L    E++ S L++K     +V  +Q+     ++   QL 
Sbjct: 855  KEEFGRIKETLEKSEARRKELE---EKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLI 911

Query: 587  TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 646
                + EA ++E +  L+  E +  E  AK   L+ +     +  D  + ++ + ++EK 
Sbjct: 912  KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971

Query: 647  ELSRKV----------EELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
                KV          +E+ A +   ++   EA  Q  + +LQ+  ++  +  K +V  E
Sbjct: 972  ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD-DLQVEEDKVNSLSKSKVKLE 1030

Query: 697  KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756
              Q  + L+   E  K  +  LE  KR+    L+  Q  I +L+ +   L E+ K++  +
Sbjct: 1031 --QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD 1088

Query: 757  LEEERA---GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAW 813
            + ++ +     + L  +LQ+  + +QA  E    EL E + A+ TA ++ E+L  +++  
Sbjct: 1089 INQQNSKIEDEQVLALQLQKKLKENQARIE----ELEEELEAERTARAKVEKLRSDLS-- 1142

Query: 814  RERYEDSQQEEAQYGAMFQEQLMTLKEECE--KARQELQEAKEKVAGIESHSELQISRQQ 871
            RE  E S++ E   GA   +  M  K E E  K R++L+EA  +     +    + +   
Sbjct: 1143 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1202

Query: 872  NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931
             EL E   NL R  Q++++++   +   DD+++  E++    K  A LE + R   +Q  
Sbjct: 1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII---KAKANLEKVSRTLEDQ-- 1257

Query: 932  TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991
                        A + + +  E Q+     +TQ A   ++ E  ++  +LE  + AL+  
Sbjct: 1258 ------------ANEYRVKLEEAQRSLNDFTTQRA--KLQTENGELARQLEE-KEALISQ 1302

Query: 992  QGQQQEERGQQEREVARLTQERGRAQADLALE-KAARAELEMRLQNALNEQRVEFATLQE 1050
              + +    QQ  ++ R  +E G+A+  LA   ++AR + ++ L+    E+    A LQ 
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQR 1361

Query: 1051 ALAHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
             L+ A       + E+A+ R   E   I+  EEL +  K+L ++L   E+          
Sbjct: 1362 VLSKA-------NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA--------- 1405

Query: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169
                        +EA+ A+ S LE+   + Q + + L   +E   A+ A  D        
Sbjct: 1406 ------------VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1453

Query: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229
             L E  Q+   SQS L S+Q+E  +  T++     A +E    +   ++E +     IS 
Sbjct: 1454 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1513

Query: 1230 LEEEVSILNRQVLEKEGESKELK------RLVMAESEKSQKLEERLRLLQAETASNSARA 1283
            L E++    + V E E   K+L+      +  + E+E S + EE  ++L+A+   N  + 
Sbjct: 1514 LTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEG-KILRAQLEFNQIK- 1571

Query: 1284 AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1343
            AE    L E+ + + +     +   ++L+  L ++     E+ +  K  +    + E   
Sbjct: 1572 AEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME--- 1628

Query: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ 1403
              +QL H +  A  ++        +Q+++ Q+   K  + +L+ + +A   L+  +   +
Sbjct: 1629 --IQLSHANRMAAEAQ--------KQVKSLQSLL-KDTQIQLDDAVRANDDLKENIAIVE 1677

Query: 1404 RE----LGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
            R       EL  LR  V + ER+ +    E    +E++ +L   +  L  + + +   ++
Sbjct: 1678 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM--ESD 1735

Query: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519
            L +   EVE      +  +E A         +AE  ++ Q T+  LE M    E    + 
Sbjct: 1736 LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME----QT 1791

Query: 1520 LEERQRFQEERQKLT-----AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
            +++ Q   +E +++       Q+++LE   RE   ++E   K+ A+S +  +  ++++K 
Sbjct: 1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851

Query: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
            +  Q  E ++   RLQ  +++LQ ++   ++ AE  +   E+A T+    ++   EL E 
Sbjct: 1852 LTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAE---EQANTNLSKFRKVQHELDEA 1908

Query: 1635 LRSLEQLQKENKELRAEAERLG 1656
                +  + +  +LRA++  +G
Sbjct: 1909 EERADIAESQVNKLRAKSRDIG 1930



 Score =  175 bits (444), Expect = 4e-43
 Identities = 251/1168 (21%), Positives = 507/1168 (43%), Gaps = 147/1168 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEK-DAQIAMM---------QQRI 258
            + T + +  R+K+ L    + R ELE ++     LL EK D Q+ +          ++R 
Sbjct: 851  MATMKEEFGRIKETLEKSEARRKELEEKMVS---LLQEKNDLQLQVQAEQDNLNDAEERC 907

Query: 259  DRLALLNEKQAASPLEPKE-LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLS 317
            D+L     +  A   E  E LE+  + N  LT +  +   +C +LK +   ++  + ++ 
Sbjct: 908  DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967

Query: 318  EENGDLSFKLREFASHLQQLQDALNELTEEH---SKATQEWLEKQAQLEKELSAALQDKK 374
            +E      K++     +  L + + +LT+E     +A Q+ L+     E ++++  + K 
Sbjct: 968  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027

Query: 375  CLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA 434
             LE++ + L+G L Q ++    L+    + K ++ GD   L+  ++    L  +  QL+ 
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLE----RAKRKLEGD---LKLTQESIMDLENDKLQLEE 1080

Query: 435  RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494
            +++  E +  QQ +K+       E+E+     L   L+ + + + + +EELE A +   A
Sbjct: 1081 KLKKKEFDINQQNSKI-------EDEQVLALQLQKKLKENQARIEELEEELE-AERTARA 1132

Query: 495  RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
            ++    + L+ EL  ++  +++     +   +  K+++A+  +  +  E+A+  L+H  E
Sbjct: 1133 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT--LQH--E 1188

Query: 555  QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR-ERDAALKQLEALEKEK 613
              +++L++K      VAE  E  + D+ Q++    E+ ++  + E D     +E + K K
Sbjct: 1189 ATAAALRKKHAD--SVAELGE--QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1244

Query: 614  AAKLEILQQQLQVANEAR---DSAQTSV-------TQAQREKAELSRKVEELQACVETAR 663
            A   ++ +     ANE R   + AQ S+        + Q E  EL+R++EE +A +    
Sbjct: 1245 ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT 1304

Query: 664  QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
            + +     Q+ +L+ QL  E           + K+ L   LQ+ +    + +   EEE  
Sbjct: 1305 RGKLSYTQQMEDLKRQLEEE----------GKAKNALAHALQSARHDCDLLREQYEEE-- 1352

Query: 724  RAADALEEQQRCISELKAETRSLVEQHKRER-KELEEERAGRKGLEARLQQLGEAHQA-- 780
               +A  E QR +S+  +E      +++ +  +  EE    +K L  RLQ   EA +A  
Sbjct: 1353 --TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410

Query: 781  ---------------ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEA 825
                           E E L  ++  + AA    + +     K +A W+++YE+SQ E  
Sbjct: 1411 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1470

Query: 826  QYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARAL 885
                  Q++  +L  E  K +   +E+ E +   +  ++      Q E+++L   L    
Sbjct: 1471 S----SQKEARSLSTELFKLKNAYEESLEHLETFKRENK----NLQEEISDLTEQLGEGG 1522

Query: 886  QQVQEKE-VRAQKLADDL---STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941
            + V E E VR Q   + L   S L+E  A+   E  ++     +  + +    R+L ++ 
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK- 1581

Query: 942  ARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ 1001
                D + E  +    R   S Q +L A  R      NE+ R++  +     + + +   
Sbjct: 1582 ----DEEMEQAKRNHQRVVDSLQTSLDAETRSR----NEVLRVKKKMEGDLNEMEIQLSH 1633

Query: 1002 QEREVARLTQERGRAQA-----DLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
              R  A   ++    Q+      + L+ A RA  +++   A+ E+R      +     A+
Sbjct: 1634 ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAV 1693

Query: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116
             E+  + ++LA+   +E ++  +L   + T   L  Q  K E +                
Sbjct: 1694 VEQTERSRKLAEQELIETSERVQLLHSQNT--SLINQKKKMESD---------------- 1735

Query: 1117 PTGPKLEALRAEVSKLEQQCQKQQEQADS--LERSLEAERASRAERDSA-LETLQGQLEE 1173
                 L  L++EV +  Q+C+  +E+A     + ++ AE   + +  SA LE ++  +E+
Sbjct: 1736 -----LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1790

Query: 1174 KAQELGH-----SQSALASAQRELAAFRTKVQD---HSKAEDEWKAQVARGRQEAER--K 1223
              ++L H      Q AL   +++L     +V++     +AE +  A+  +G +++ER  K
Sbjct: 1791 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIK 1850

Query: 1224 NSLISSLEEEVSILNRQVL--EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
                 + E++ ++L  Q L  + + + K  KR      E++     + R +Q E      
Sbjct: 1851 ELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEE 1910

Query: 1282 RAAERSSALREEVQSLREEAEKQRVASE 1309
            RA    S + +     R+   KQ++  E
Sbjct: 1911 RADIAESQVNKLRAKSRDIGAKQKMHDE 1938



 Score =  162 bits (411), Expect = 2e-39
 Identities = 241/1102 (21%), Positives = 473/1102 (42%), Gaps = 175/1102 (15%)

Query: 651  KVEELQACVETARQ--EQHEAQAQVAELELQLRSEQQKATEKERVA--QEKDQLQEQLQA 706
            K++ L    ET ++     E   ++ E  L+    ++K  E++ V+  QEK+ LQ Q+QA
Sbjct: 837  KIKPLLKSAETEKEMATMKEEFGRIKET-LEKSEARRKELEEKMVSLLQEKNDLQLQVQA 895

Query: 707  LKESLK----------VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756
             +++L             K  LE + +   + LE+++   +EL A+ R L ++    +K+
Sbjct: 896  EQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD 955

Query: 757  LEEERAGRKGLEARLQQLG-EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
            +++       LE  L ++  E H  E +V  + L E MA     +    +L KE  A +E
Sbjct: 956  IDD-------LELTLAKVEKEKHATENKV--KNLTEEMAG---LDEIIAKLTKEKKALQE 1003

Query: 816  RYE----DSQQEEAQYGAM------FQEQLMTLK---EECEKARQELQEAKEKVAGIESH 862
             ++    D Q EE +  ++       ++Q+  L+   E+ +K R +L+ AK K+ G    
Sbjct: 1004 AHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1063

Query: 863  SELQISRQQNELAELHANLARAL-------QQVQEKEVRAQKLADDLSTLQEKMAATSKE 915
            ++  I   +N+  +L   L +          ++++++V A +L   L   Q ++    +E
Sbjct: 1064 TQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE 1123

Query: 916  VARLETLVRKAGEQQETASRELVKEPAR---AGDRQPEWLEEQQGRQFCSTQAALQAMER 972
            +    T   K  + +   SREL +   R   AG      +E  + R+     A  Q M R
Sbjct: 1124 LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMRR 1178

Query: 973  EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE--------- 1023
            + E+   + E   AAL +       E G+Q   + R+ Q+  + +++  LE         
Sbjct: 1179 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238

Query: 1024 -----KAARAELEMRLQNALNEQRVEFATLQEALAHALTEK---EGKDQELAKLRGLEAA 1075
                 KA   ++   L++  NE RV+    Q +L    T++   + ++ ELA+    + A
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEA 1298

Query: 1076 QIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135
             I +L   + +  Q  E L ++ +E      A + A          L++ R +   L +Q
Sbjct: 1299 LISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHA----------LQSARHDCDLLREQ 1348

Query: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195
             +++ E    L+R L    +  A+  +  ET   Q  E+ +E          A+++LA  
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE----------AKKKLAQ- 1397

Query: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
              ++QD  +A +   A+ +   +   R  + I  L  +V   N      + + +   +++
Sbjct: 1398 --RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1455

Query: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL 1315
                +K ++ +  L   Q E  S S    +  +A  E ++ L    E  +  ++NL++E+
Sbjct: 1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL----ETFKRENKNLQEEI 1511

Query: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS-ELLPAKHLCQQLQAEQ 1374
            +   E+  E G+ +   ++   +K+  +  L+L+    +A  S E    K L  QL+  Q
Sbjct: 1512 SDLTEQLGEGGKNVHELEK--VRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569

Query: 1375 AAAEKRHR-----EELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAE 1429
              AE   +     EE+EQ+K+                       Q+V +  +T+  L AE
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRN---------------------HQRVVDSLQTS--LDAE 1606

Query: 1430 KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET 1489
              S  E L + KK  G L E               +E++L  A          + A+A+ 
Sbjct: 1607 TRSRNEVLRVKKKMEGDLNE---------------MEIQLSHANR--------MAAEAQK 1643

Query: 1490 RLAEVQREAQSTARELEVMTAKYEGAK--VKVLEERQRF-QEERQKLTAQVEQLEVFQRE 1546
            ++  +Q   + T  +L+      +  K  + ++E R    Q E ++L A VEQ E     
Sbjct: 1644 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE----- 1698

Query: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
                    S+KLA+ +       ++++ + +Q      + +++++ L +LQ+++   E+A
Sbjct: 1699 -------RSRKLAEQELIET--SERVQLLHSQNTSLINQKKKMESDLTQLQSEV---EEA 1746

Query: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA-GLK 1665
             +  +   EKAK          +EL+++  +   L++  K +    + L H L +A  + 
Sbjct: 1747 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1806

Query: 1666 TKEAEQTCRHLTAQVRSLEAQV 1687
             K  ++  + L A+VR LE ++
Sbjct: 1807 LKGGKKQLQKLEARVRELEGEL 1828



 Score =  140 bits (353), Expect = 1e-32
 Identities = 199/875 (22%), Positives = 384/875 (43%), Gaps = 77/875 (8%)

Query: 865  LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
            L+ +  + E+A +     R  + +++ E R ++L + + +L ++      +V   +  + 
Sbjct: 842  LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
             A E+ +   +  ++  A+  +   E LE+++        A L A +R+ E   +EL++ 
Sbjct: 902  DAEERCDQLIKNKIQLEAKVKEMN-ERLEDEE-----EMNAELTAKKRKLEDECSELKKD 955

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
               L  +  + ++E+   E +V  LT+E       +A     +  L+   Q AL++ +VE
Sbjct: 956  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015

Query: 1045 ------FATLQEALAHALTEKEGKDQELAKLR-GLEAAQIKELEELRQTVK--------- 1088
                   +  +  L   + + EG  ++  K+R  LE A+ K   +L+ T +         
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075

Query: 1089 -QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
             QL+E+L KKE +                    K+E  +    +L+++ ++ Q + + LE
Sbjct: 1076 LQLEEKLKKKEFD--------------INQQNSKIEDEQVLALQLQKKLKENQARIEELE 1121

Query: 1148 RSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-----AAFRTKVQDH 1202
              LEAER +RA+ +     L  +LEE ++ L  +  A  S Q E+     A F+   +D 
Sbjct: 1122 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDL 1180

Query: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS 1262
             +A  + +A  A  R+   +    ++ L E++  L R   + E E  E K  +   +   
Sbjct: 1181 EEATLQHEATAAALRK---KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1237

Query: 1263 QKLEERLRLLQAETASNSARAAERSSALREEVQSLRE-EAEKQRVASENLRQELTSQAER 1321
            +++ +    L+  + +   +A E    L E  +SL +   ++ ++ +EN   EL  Q E 
Sbjct: 1238 EQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN--GELARQLEE 1295

Query: 1322 AEELGQELKAWQEKFFQKEQALST-LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
             E L  +L   +  + Q+ + L   L+ E  +  AL   L  A+H C  L+ EQ   E  
Sbjct: 1296 KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR-EQYEEETE 1354

Query: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR-AEKASYA--EQL 1437
             + EL++    A    A+  R + E   +    +    +++ AQ+L+ AE+A  A   + 
Sbjct: 1355 AKAELQRVLSKANSEVAQW-RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413

Query: 1438 SMLKKAHGLLAEENRGLG---ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV 1494
            S L+K    L  E   L    ER+N     L+ +  +  +K + E      ++++ L   
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK-QRNFDKILAEWKQKYEESQSELESS 1472

Query: 1495 QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554
            Q+EA+S + EL  +   YE +    LE  + F+ E + L  ++  L     E  K V EL
Sbjct: 1473 QKEARSLSTELFKLKNAYEES----LEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL 1528

Query: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614
             K     +      Q  L+  +A     + +  R Q + N+++A++ +K    +    +M
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE---EM 1585

Query: 1615 EKAKTHYDAKKQQNQ-ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673
            E+AK ++       Q  L  + RS  ++ +  K++  +   +  +L  A     EA++  
Sbjct: 1586 EQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQK-- 1643

Query: 1674 RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALK 1708
                 QV+SL++ +     QL D  +   A D LK
Sbjct: 1644 -----QVKSLQSLLKDTQIQLDDAVR---ANDDLK 1670



 Score =  114 bits (284), Expect = 1e-24
 Identities = 158/744 (21%), Positives = 313/744 (42%), Gaps = 117/744 (15%)

Query: 1001 QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
            + E+E+A + +E GR +  L   +A R ELE ++ + L E+  +     +A    L + E
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKN-DLQLQVQAEQDNLNDAE 904

Query: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGP 1120
             +  +L          IK   +L   VK++ E+L  +E+ +A                  
Sbjct: 905  ERCDQL----------IKNKIQLEAKVKEMNERLEDEEEMNAE----------------- 937

Query: 1121 KLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGH 1180
                L A+  KLE +C + ++  D LE +L       A+ +      + +++   +E+  
Sbjct: 938  ----LTAKKRKLEDECSELKKDIDDLELTL-------AKVEKEKHATENKVKNLTEEMAG 986

Query: 1181 SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ 1240
                +A   +E  A +   + H +A D+ +        E ++ NSL  S  +    L +Q
Sbjct: 987  LDEIIAKLTKEKKALQ---EAHQQALDDLQV-------EEDKVNSLSKSKVK----LEQQ 1032

Query: 1241 VLEKEGESKELKRLVMAESEKSQKLEERLRLLQA---ETASNSARAAERSSALREEVQSL 1297
            V + EG  ++ K++ M      +KLE  L+L Q    +  ++  +  E+      ++   
Sbjct: 1033 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQ 1092

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
              + E ++V +  L+++L     R EEL +EL+A +    + E+  S L  E       +
Sbjct: 1093 NSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152

Query: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELE----QSKQAAGGLRAELLRAQRELGELIPLR 1413
             E   A  +  ++  ++ A  ++ R +LE    Q +  A  LR +   +  ELGE I   
Sbjct: 1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1212

Query: 1414 QKVAEQ-ERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA 1472
            Q+V ++ E+   + + E       +  + KA   L + +R L ++AN  R    V+L++A
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR----VKLEEA 1268

Query: 1473 REKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK 1532
            +            D  T+ A++Q E    AR+LE                      E++ 
Sbjct: 1269 QRSL--------NDFTTQRAKLQTENGELARQLE----------------------EKEA 1298

Query: 1533 LTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592
            L +Q+ + ++     T+Q+E+L ++L +  +A       L++       ++ +   L+ Q
Sbjct: 1299 LISQLTRGKL---SYTQQMEDLKRQLEEEGKAKNALAHALQS-------ARHDCDLLREQ 1348

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA 1652
              E      + E  AE   LQ   +K + +  + + +   + ++  E+L++  K+L    
Sbjct: 1349 YEE------ETEAKAE---LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399

Query: 1653 ERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREP 1712
            +     ++    K    E+T   L  ++  L   V  ++     L K Q   D + +   
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--- 1456

Query: 1713 QAKPQLDLSIDSLDLSCEEGTPLS 1736
            + K + + S   L+ S +E   LS
Sbjct: 1457 EWKQKYEESQSELESSQKEARSLS 1480



 Score = 41.2 bits (95), Expect = 0.011
 Identities = 45/199 (22%), Positives = 91/199 (45%), Gaps = 18/199 (9%)

Query: 1531 QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
            ++L+  + +++   R Q  ++E   KK+ +   A  V Q  ++A     G       +L 
Sbjct: 781  ERLSRIITRMQAQARGQLMRIE--FKKIVERRDALLVIQWNIRAFM---GVKNWPWMKLY 835

Query: 1591 AQLNEL-QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELR 1649
             ++  L ++  ++KE A    K +  + K   +  + + +EL+E++ SL Q +K + +L+
Sbjct: 836  FKIKPLLKSAETEKEMAT--MKEEFGRIKETLEKSEARRKELEEKMVSLLQ-EKNDLQLQ 892

Query: 1650 AEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKS 1709
             +AE+             +AE+ C  L      LEA+V   +++L D  +      A K 
Sbjct: 893  VQAEQDN---------LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKR 943

Query: 1710 REPQAKPQLDLSIDSLDLS 1728
            +      +L   ID L+L+
Sbjct: 944  KLEDECSELKKDIDDLELT 962


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  215 bits (548), Expect = 3e-55
 Identities = 284/1270 (22%), Positives = 553/1270 (43%), Gaps = 183/1270 (14%)

Query: 253  MMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEK-SQMDR 311
            M  +R+ R+    + Q+   L   E ++L ++ +SL + +   ++    +K     ++  
Sbjct: 776  MRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLV-IQWNIRAFMGVKNWPWMKLYF 834

Query: 312  KINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQ 371
            KI  L         K  E    +  +++    L E   K+      ++ +LE+++ + LQ
Sbjct: 835  KIKPL--------LKSAEREKEMASMKEEFTRLKEALEKSEA----RRKELEEKMVSLLQ 882

Query: 372  DKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQ 431
            +K  L+ + +  Q  L+  EE   QL  N  Q + +V     +LE  ++  A L A   +
Sbjct: 883  EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK 942

Query: 432  LQARVEMLETERGQQE---AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
            L+     L+ +    E   AK+  E+   E + + L+  +  L   I+ L++ K+ L++A
Sbjct: 943  LEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1002

Query: 489  SQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT-------LQQ 541
             Q     L A+   + + LT     ++QQ  +L G  +Q K+ +  L +        L+ 
Sbjct: 1003 HQQALDDLQAEEDKVNT-LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1061

Query: 542  QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDA 601
             +++   L +  +QL   LK+K+ +L  +                       A + +  A
Sbjct: 1062 TQESIMDLENDKQQLDERLKKKDFELNAL----------------------NARIEDEQA 1099

Query: 602  ALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEEL--QACV 659
               QL+   KE  A++E L+++L+    AR   +   +   RE  E+S ++EE      V
Sbjct: 1100 LGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSV 1159

Query: 660  ETARQEQHEAQAQVAELELQLRSEQQKATE---KERVAQEKDQLQEQ---LQALKESLKV 713
            +    ++ EA+ Q    +L+  + Q +AT    +++ A    +L EQ   LQ +K+ L+ 
Sbjct: 1160 QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219

Query: 714  TKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
             K   + E       +E+  +  + L+   R+L +Q    R + EE +     L ++  +
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK 1279

Query: 774  LGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ---QEEAQYGAM 830
            L    Q E   L R+L E        E+   QL +    + ++ ED +   +EE +    
Sbjct: 1280 L----QTENGELSRQLDE-------KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNA 1328

Query: 831  FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL-ARALQQVQ 889
                L + + +C+  R++ +E  E  A ++      +S+  +E+A+        A+Q+ +
Sbjct: 1329 LAHALQSARHDCDLLREQYEEETEAKAELQR----VLSKANSEVAQWRTKYETDAIQRTE 1384

Query: 890  EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG---- 945
            E E   +KLA  L   +E + A + + + LE    +   + E    ++ +  A A     
Sbjct: 1385 ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1444

Query: 946  -DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES----QGQQQEERG 1000
              R  + +  +  +++  +Q+ L++ ++EA  +  EL +L+ A  ES    +  ++E + 
Sbjct: 1445 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1504

Query: 1001 QQEREVARLTQERGRAQADLALEKAARAELE---MRLQNALNEQRVEFATLQEALAHALT 1057
             QE E++ LT++ G +   +   +  R +LE   M LQ+AL E              +L 
Sbjct: 1505 LQE-EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA-----------SLE 1552

Query: 1058 EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117
             +EGK         +  AQ+    E  Q   +++ +LA+K++E                 
Sbjct: 1553 HEEGK---------ILRAQL----EFNQIKAEIERKLAEKDEE----------------- 1582

Query: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177
                          +EQ  +      DSL+ SL+AE  SR E     + ++G L E   +
Sbjct: 1583 --------------MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ 1628

Query: 1178 LGHSQSALASAQRELAAFRT-------KVQDHSKAEDEWKAQVARGRQEAERKNSLISSL 1230
            L H+    A AQ+++ + ++       ++ D  +A D+ K  +A      ER+N+L+ + 
Sbjct: 1629 LSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA----IVERRNNLLQAE 1684

Query: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290
             EE+    R V+E+   S++L    + E+       ER++LL ++  S   +  +  + L
Sbjct: 1685 LEEL----RAVVEQTERSRKLAEQELIET------SERVQLLHSQNTSLINQKKKMDADL 1734

Query: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEEL--GQELKAWQEKFFQKEQALSTLQL 1348
             +    + E  ++ R A E  ++ +T  A  AEEL   Q+  A  E+  +K    +   L
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER-MKKNMEQTIKDL 1793

Query: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408
            +H   +A    L   K   Q+L+A     E     E +++ ++  G+R    +++R + E
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMR----KSERRIKE 1849

Query: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLG-RQFLEV 1467
               L  +  E  +   +L+       ++L +  KA+   AEE     E+AN    +F +V
Sbjct: 1850 ---LTYQTEEDRKNLLRLQ----DLVDKLQLKVKAYKRQAEEAE---EQANTNLSKFRKV 1899

Query: 1468 --ELDQAREK 1475
              ELD+A E+
Sbjct: 1900 QHELDEAEER 1909



 Score =  197 bits (501), Expect = 9e-50
 Identities = 265/1179 (22%), Positives = 518/1179 (43%), Gaps = 132/1179 (11%)

Query: 516  QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
            ++++E+A +K    E+  +L + L++ E   + L    E++ S L++K     +V  +Q+
Sbjct: 844  EREKEMASMK----EEFTRLKEALEKSEARRKELE---EKMVSLLQEKNDLQLQVQAEQD 896

Query: 576  --ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
              A  ++   QL     + EA ++E +  L+  E +  E  AK   L+ +        D 
Sbjct: 897  NLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDD 956

Query: 634  AQTSVTQAQREKAELSRKV----------EELQACVETARQEQHEAQAQVAELELQLRSE 683
             + ++ + ++EK     KV          +E+ A +   ++   EA  Q  +    L++E
Sbjct: 957  LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD---DLQAE 1013

Query: 684  QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
            + K     +   + +Q  + L+   E  K  +  LE  KR+    L+  Q  I +L+ + 
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073

Query: 744  RSLVEQHKRERKEL-------EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
            + L E+ K++  EL       E+E+A    L+ +L++L    QA  E    EL E + A+
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL----QARIE----ELEEELEAE 1125

Query: 797  HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE--KARQELQEAKE 854
             TA ++ E+L  +++  RE  E S++ E   GA   +  M  K E E  K R++L+EA  
Sbjct: 1126 RTARAKVEKLRSDLS--RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183

Query: 855  KVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914
            +     +    + +    EL E   NL R  Q++++++   +   DD+++  E++    K
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII---K 1240

Query: 915  EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREA 974
              A LE + R   E Q    R   +E  R+ +               S +A LQ    E 
Sbjct: 1241 AKANLEKMCRTL-EDQMNEHRSKAEETQRSVN------------DLTSQRAKLQTENGEL 1287

Query: 975  EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE-KAARAELEMR 1033
             +  +E E L + L   +        QQ  ++ R  +E  +A+  LA   ++AR + ++ 
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYT----QQLEDLKRQLEEEVKAKNALAHALQSARHDCDL- 1342

Query: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQLKE 1092
            L+    E+    A LQ  L+ A       + E+A+ R   E   I+  EEL +  K+L +
Sbjct: 1343 LREQYEEETEAKAELQRVLSKA-------NSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1395

Query: 1093 QLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEA 1152
            +L + E+                      +EA+ A+ S LE+   + Q + + L   +E 
Sbjct: 1396 RLQEAEEA---------------------VEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434

Query: 1153 ERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQ 1212
              A+ A  D         L E  Q+   SQS L S+Q+E  +  T++     A +E    
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494

Query: 1213 VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK------RLVMAESEKSQKLE 1266
            +   ++E +     IS L E++    + + E E   K+L+      +  + E+E S + E
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554

Query: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG 1326
            E  ++L+A+   N  + AE    L E+ + + +         ++L+  L ++     E  
Sbjct: 1555 EG-KILRAQLEFNQIK-AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612

Query: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386
            +  K  +    + E     +QL H +  A  ++        +Q+++ Q+   K  + +L+
Sbjct: 1613 RVKKKMEGDLNEME-----IQLSHANRMAAEAQ--------KQVKSLQSLL-KDTQIQLD 1658

Query: 1387 QSKQAAGGLRAELLRAQRE----LGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
             + +A   L+  +   +R       EL  LR  V + ER+ +    E    +E++ +L  
Sbjct: 1659 DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHS 1718

Query: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502
             +  L  + + +   A+L +   EVE      +  +E A         +AE  ++ Q T+
Sbjct: 1719 QNTSLINQKKKMD--ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1776

Query: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLT-----AQVEQLEVFQREQTKQVEELSKK 1557
              LE M    E    + +++ Q   +E +++       Q+++LE   RE   ++E   K+
Sbjct: 1777 AHLERMKKNME----QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832

Query: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617
             A+S +  +  ++++K +  Q  E ++   RLQ  +++LQ ++   ++ AE  +   E+A
Sbjct: 1833 NAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE---EQA 1889

Query: 1618 KTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLG 1656
             T+    ++   EL E     +  + +  +LRA++  +G
Sbjct: 1890 NTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1928



 Score =  170 bits (430), Expect = 2e-41
 Identities = 211/1021 (20%), Positives = 449/1021 (43%), Gaps = 107/1021 (10%)

Query: 737  SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAH---QAETEVLRRELAEAM 793
            +E + E  S+ E+  R ++ LE+  A RK LE ++  L +     Q + +  +  LA+A 
Sbjct: 843  AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA- 901

Query: 794  AAQHTAESECEQLVK-------EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
                  E  C+QL+K       +V    ER ED ++  A+  A  ++    L++EC + +
Sbjct: 902  ------EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK----LEDECSELK 951

Query: 847  QELQEAKEKVAGIESH---SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
            +++ + +  +A +E     +E ++     E+A L   +A+  ++ +  +   Q+  DDL 
Sbjct: 952  RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011

Query: 904  TLQEKMAATSKEVARLETLV----------RKAGEQQETASREL------VKEPARAGDR 947
              ++K+   +K   +LE  V          +K     E A R+L       +E     + 
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1071

Query: 948  QPEWLEEQQGRQFCSTQAALQAMERE---AEQMGNELERLRAALMESQGQQQEERGQQER 1004
              + L+E+  ++     A    +E E     Q+  +L+ L+A + E + + + ER  + +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131

Query: 1005 EVARLTQERGRAQADLA--LEKAARA---ELEMRLQNALNEQRV----EFATLQ-EALAH 1054
             V +L  +  R   +++  LE+A  A   ++EM  +     Q++    E ATLQ EA A 
Sbjct: 1132 -VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190

Query: 1055 ALTEKEGKD-----------QELAKLRGLEAAQIK-ELEELRQTVKQLKEQLAKKEKEHA 1102
            AL +K               Q + +    E ++ K EL+++   ++Q+ +  A  EK   
Sbjct: 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR 1250

Query: 1103 SGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDS 1162
            +     +E   + E T   +  L ++ +KL+ +  +   Q D  E  +      +     
Sbjct: 1251 TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQ 1310

Query: 1163 ALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAER 1222
             LE L+ QLEE+ +       AL SA+ +    R + ++ ++A+ E +  +++   E  +
Sbjct: 1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370

Query: 1223 KNSLISS----LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETAS 1278
              +   +      EE+    +++ ++  E++E    V A+    +K + RL+    +   
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV 1430

Query: 1279 NSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQ 1338
            +  R+   ++AL ++ ++  +   + +   E  + EL S  + A  L  EL   +  + +
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490

Query: 1339 KEQALSTLQLEHTSTQALVSELLPAK-------HLCQQLQAEQAAAEKRHREELEQSKQA 1391
              + L T + E+ + Q  +S+L           H  ++++ +  A +   +  LE+++ +
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 1550

Query: 1392 AGGLRAELLRAQRELGEL-IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
                  ++LRAQ E  ++   + +K+AE++   +Q +       + L     A      E
Sbjct: 1551 LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 1610

Query: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
               + ++       +E++L  A          + A+A+ ++  +Q   + T  +L+    
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHANR--------MAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662

Query: 1511 KYEGAK--VKVLEERQRF-QEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKV 1567
              +  K  + ++E R    Q E ++L A VEQ E             S+KLA+ +     
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTE------------RSRKLAEQELIET- 1709

Query: 1568 QQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ 1627
              ++++ + +Q      + +++ A L++LQ ++   E+A +  +   EKAK         
Sbjct: 1710 -SERVQLLHSQNTSLINQKKKMDADLSQLQTEV---EEAVQECRNAEEKAKKAITDAAMM 1765

Query: 1628 NQELQEQLRSLEQLQKENKELRAEAERLGHELQQA-GLKTKEAEQTCRHLTAQVRSLEAQ 1686
             +EL+++  +   L++  K +    + L H L +A  +  K  ++  + L A+VR LE +
Sbjct: 1766 AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE 1825

Query: 1687 V 1687
            +
Sbjct: 1826 L 1826



 Score =  159 bits (401), Expect = 4e-38
 Identities = 224/1061 (21%), Positives = 450/1061 (42%), Gaps = 100/1061 (9%)

Query: 217  RRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK 276
            R+L+ + ++ + + D+LEL LA+  K   EK A    ++   + +A L+E  A    E K
Sbjct: 941  RKLEDECSELKRDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997

Query: 277  ELEELR----DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
             L+E      D  ++   +++   K    L+ +   ++  + Q  +   DL    R+   
Sbjct: 998  ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1057

Query: 333  HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
             L+  Q+++ +L  +  +  +   +K  +L   L+A ++D++ L           SQL++
Sbjct: 1058 DLKLTQESIMDLENDKQQLDERLKKKDFEL-NALNARIEDEQALG----------SQLQK 1106

Query: 393  HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
             L +LQ               ++E L++E   L A  T  +A+VE L ++   +E + ++
Sbjct: 1107 KLKELQ--------------ARIEELEEE---LEAERT-ARAKVEKLRSDL-SRELEEIS 1147

Query: 453  ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512
            ER   EE     S  I   +   +   + + +LE+A+  H A   A        +  L  
Sbjct: 1148 ER--LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1205

Query: 513  TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
             I    +    L+++  E + +L       EQ  +  +  +E++  +L+ +  + +  AE
Sbjct: 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA-KANLEKMCRTLEDQMNEHRSKAE 1264

Query: 573  KQEATRQDHAQQ---LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
            + + +  D   Q   L T   E    L E++A + QL   +     +LE L++QL+   +
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1324

Query: 630  ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689
            A+++   ++  A+ +   L  + EE        ++   +A ++VA+   +  ++  + TE
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1384

Query: 690  KERVAQEK--DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
            +   A++K   +LQE  +A+ E++     SLE+ K R  + +E+    +    A   +L 
Sbjct: 1385 ELEEAKKKLAQRLQEAEEAV-EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1443

Query: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807
            ++ +   K L E +   +  ++ L    E+ Q E   L  EL +   A   +    E   
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSEL----ESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499

Query: 808  KEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI 867
            +E    +E   D  ++    G    E L  ++++ E  + ELQ A E+      H E +I
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHE-LEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558

Query: 868  SRQQNELAELHANLARALQQVQEKEVRAQ----KLADDLSTLQEKMAATSKEVAR----- 918
             R Q E  ++ A + R L +  E+  +A+    ++ D L T  +    +  E  R     
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618

Query: 919  ------LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
                  +E  +  A      A +++    +   D Q +  +  +         A+  +ER
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI--VER 1676

Query: 973  EAEQMGNELERLRAALMESQGQQQEERGQQER-EVARLTQERGRAQADLALEKAARAELE 1031
                +  ELE LRA +   Q ++  +  +QE  E +   Q        L  +K       
Sbjct: 1677 RNNLLQAELEELRAVV--EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734

Query: 1032 MRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLK 1091
             +LQ  + E   E    +E    A+T+     +EL K +   A   +  + + QT+K L+
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794

Query: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQ-ADSLERSL 1150
             +L + E+    G   Q             L+ L A V +LE + + +Q++ A+S++   
Sbjct: 1795 HRLDEAEQIALKGGKKQ-------------LQKLEARVRELENELEAEQKRNAESVKGMR 1841

Query: 1151 EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK 1210
            ++ER         ++ L  Q EE  + L   Q  +   Q ++ A++ + ++   AE++  
Sbjct: 1842 KSER--------RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE---AEEQAN 1890

Query: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251
              +++ R+        +   EE   I   QV +   +S+++
Sbjct: 1891 TNLSKFRKVQHE----LDEAEERADIAESQVNKLRAKSRDI 1927



 Score =  154 bits (390), Expect = 7e-37
 Identities = 185/768 (24%), Positives = 339/768 (44%), Gaps = 82/768 (10%)

Query: 967  LQAMEREAEQ--MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK 1024
            L++ ERE E   M  E  RL+ AL +S+ +++E     E ++  L QE+   Q  +  E+
Sbjct: 840  LKSAEREKEMASMKEEFTRLKEALEKSEARRKE----LEEKMVSLLQEKNDLQLQVQAEQ 895

Query: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQEL-AKLRGLEAAQIKELEEL 1083
               A+ E R    + + +++     + +   L ++E  + EL AK R LE     E  EL
Sbjct: 896  DNLADAEERCDQLI-KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE----DECSEL 950

Query: 1084 RQTVKQLKEQLAKKEKE-HASGSGAQS---EAAGRTEPTGP--------------KLEAL 1125
            ++ +  L+  LAK EKE HA+ +  ++   E AG  E                   L+ L
Sbjct: 951  KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1010

Query: 1126 RAE---VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL---EEKAQELG 1179
            +AE   V+ L +   K ++Q D LE SLE E+  R + + A   L+G L   +E   +L 
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE 1070

Query: 1180 HSQSALASAQR----ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235
            + +  L    +    EL A   +++D    E    +Q+ +  +E + +   I  LEEE+ 
Sbjct: 1071 NDKQQLDERLKKKDFELNALNARIED----EQALGSQLQKKLKELQAR---IEELEEEL- 1122

Query: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295
                     E E     ++    S+ S++LEE    L+    + S +  E +     E Q
Sbjct: 1123 ---------EAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI-EMNKKREAEFQ 1172

Query: 1296 SLREEAEKQRVASENLRQELTSQ-AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQ 1354
             +R + E+  +  E     L  + A+   ELG+++   Q    + E+  S  +LE     
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1232

Query: 1355 ALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQ 1414
            + + +++ AK   +++          HR + E+++++   L ++  + Q E GEL    +
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL---SR 1289

Query: 1415 KVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474
            ++ E+E    QL   K +Y +QL  LK+    L EE +     A+   Q    + D  RE
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQ---LEEEVKAKNALAH-ALQSARHDCDLLRE 1345

Query: 1475 KYVQELAAVRADAETRLAEVQREAQSTARELEV----MTAKYEGAKVKVLEERQRFQEER 1530
            +Y +E  A +A+ +  L++   E      + E      T + E AK K+ +  Q  +E  
Sbjct: 1346 QYEEETEA-KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV 1404

Query: 1531 QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK-------LKAVQAQGGESQ 1583
            + + A+   LE  +     ++E+L   +  S+ A+    +K       L   + +  ESQ
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464

Query: 1584 QEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL----RSLE 1639
             E +  Q +   L  +L + + A E     +E  K      +++  +L EQL    +++ 
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH 1524

Query: 1640 QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQV 1687
            +L+K  K+L AE   L   L++A    +  E        +   ++A++
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572



 Score =  142 bits (357), Expect = 5e-33
 Identities = 203/875 (23%), Positives = 374/875 (42%), Gaps = 77/875 (8%)

Query: 865  LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
            L+ + ++ E+A +     R  + +++ E R ++L + + +L ++      +V   +  + 
Sbjct: 840  LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899

Query: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
             A E+ +   +  ++  A+  +   E LE+++        A L A +R+ E   +EL+R 
Sbjct: 900  DAEERCDQLIKNKIQLEAKVKEMN-ERLEDEE-----EMNAELTAKKRKLEDECSELKRD 953

Query: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQ---ADLALEKAARAELEMRLQNALNEQ 1041
               L  +  + ++E+   E +V  LT+E        A L  EK A  E   +  + L  +
Sbjct: 954  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013

Query: 1042 RVEFATLQEA---LAHALTEKEGKDQELAKLR-GLEAAQIK----------ELEELRQTV 1087
              +  TL +A   L   + + EG  ++  K+R  LE A+ K           + +L    
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073

Query: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
            +QL E+L KK+ E                    ++E  +A  S+L+++ ++ Q + + LE
Sbjct: 1074 QQLDERLKKKDFE--------------LNALNARIEDEQALGSQLQKKLKELQARIEELE 1119

Query: 1148 RSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-----AAFRTKVQDH 1202
              LEAER +RA+ +     L  +LEE ++ L  +  A  S Q E+     A F+   +D 
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDL 1178

Query: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK-RLVMAESEK 1261
             +A  + +A  A  R+   +    ++ L E++  L R   + E E  E K  L    S  
Sbjct: 1179 EEATLQHEATAAALRK---KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235

Query: 1262 SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
             Q ++ +  L +            RS A  EE Q    +   QR   +    EL+ Q + 
Sbjct: 1236 EQIIKAKANLEKMCRTLEDQMNEHRSKA--EETQRSVNDLTSQRAKLQTENGELSRQLDE 1293

Query: 1322 AEELGQELKAWQEKFFQKEQALST-LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
             E L  +L   +  + Q+ + L   L+ E  +  AL   L  A+H C  L+ EQ   E  
Sbjct: 1294 KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR-EQYEEETE 1352

Query: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR-AEKASYA--EQL 1437
             + EL++    A    A+  R + E   +    +    +++ AQ+L+ AE+A  A   + 
Sbjct: 1353 AKAELQRVLSKANSEVAQW-RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKC 1411

Query: 1438 SMLKKAHGLLAEENRGLG---ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV 1494
            S L+K    L  E   L    ER+N     L+ +  +  +K + E      ++++ L   
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK-QRNFDKILAEWKQKYEESQSELESS 1470

Query: 1495 QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554
            Q+EA+S + EL  +   YE +    LE  + F+ E + L  ++  L        K + EL
Sbjct: 1471 QKEARSLSTELFKLKNAYEES----LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHEL 1526

Query: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614
             K     +      Q  L+  +A     + +  R Q + N+++A++ +K    +    +M
Sbjct: 1527 EKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE---EM 1583

Query: 1615 EKAK-THYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673
            E+AK  H          L  + RS  +  +  K++  +   +  +L  A     EA++  
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQK-- 1641

Query: 1674 RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALK 1708
                 QV+SL++ +     QL D  +   A D LK
Sbjct: 1642 -----QVKSLQSLLKDTQIQLDDAVR---ANDDLK 1668



 Score =  136 bits (342), Expect = 2e-31
 Identities = 198/946 (20%), Positives = 407/946 (43%), Gaps = 96/946 (10%)

Query: 213  QFQMRRLKKQLADERSNRDELELELAENRKLLTE----KDAQIAMMQQRIDRLALLNEKQ 268
            +  + R K++L  +     E  ++L  +++ L E    KD ++  +  RI+      ++Q
Sbjct: 1045 RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE------DEQ 1098

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
            A      K+L+EL+        R+ E  ++ +  +T ++++++  + LS E  ++S +L 
Sbjct: 1099 ALGSQLQKKLKELQ-------ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ--GK 386
            E A     +Q  +N+  E   +  +  LE +A L+ E +AA   KK  +   E+ +    
Sbjct: 1152 E-AGGATSVQIEMNKKREAEFQKMRRDLE-EATLQHEATAAALRKKHADSVAELGEQIDN 1209

Query: 387  LSQLEEHLSQLQDNPPQEKGEVLGDVLQL----ETLKQEAATLAANNTQLQARVEMLETE 442
            L ++++ L + +     E  +V  ++ Q+      L++   TL     + +++ E  ET+
Sbjct: 1210 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE--ETQ 1267

Query: 443  RG-----QQEAKLLAERGHFEEEKQQLSSLITDLQSS----ISNLSQAKEELEQASQAHG 493
            R       Q AKL  E G    +  +  +LI+ L          L   K +LE+  +A  
Sbjct: 1268 RSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1327

Query: 494  ARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQV 553
            A L   + S   +   L    +++ +  A L++   +  +++AQ   + E  +     ++
Sbjct: 1328 A-LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1386

Query: 554  EQLSSSLKQKEQQLKEVAEKQEA---TRQDHAQQLATAAEEREASLRERDAALKQLEALE 610
            E+    L Q+ Q+ +E  E   A   + +    +L    E+    +   +AA   L+  +
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446

Query: 611  KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
            +     L   +Q+ + +    +S+Q        E  +L    EE    +ET ++E    Q
Sbjct: 1447 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1506

Query: 671  AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730
             ++++L  QL S  +   E E+V   + QL+ +   L+ +L+  + SLE E+ +   A  
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKV---RKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563

Query: 731  EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA 790
            E     +++KAE      + K   K+ E E+A R  L   +  L  +  AET    R   
Sbjct: 1564 E----FNQIKAEI-----ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAET----RSRN 1609

Query: 791  EAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850
            EA+  +   E +  ++  +++       ++Q++     ++ ++  + L ++  +A  +L 
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL-DDAVRANDDL- 1667

Query: 851  EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMA 910
              KE +A +E  + L     Q EL EL A        V E+  R++KLA      ++++ 
Sbjct: 1668 --KENIAIVERRNNL----LQAELEELRA--------VVEQTERSRKLA------EQELI 1707

Query: 911  ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970
             TS+ V  L +       Q++    +L +      +   E    ++  +   T AA+ A 
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767

Query: 971  EREAEQ-MGNELERLRAALMESQGQQQEERGQQER--EVARLTQERGRAQADLALEKAAR 1027
            E + EQ     LER++      +  +Q  +  Q R  E  ++  + G+ Q      +   
Sbjct: 1768 ELKKEQDTSAHLERMK------KNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821

Query: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE-LAKLRGLEAAQIKELEELRQT 1086
             E E+  +   N + V+     E     LT +  +D++ L +L+ L       +++L+  
Sbjct: 1822 LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDL-------VDKLQLK 1874

Query: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
            VK  K Q  + E++  +      +     +    + +   ++V+KL
Sbjct: 1875 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920



 Score =  107 bits (266), Expect = 2e-22
 Identities = 157/744 (21%), Positives = 303/744 (40%), Gaps = 117/744 (15%)

Query: 1001 QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
            ++E+E+A + +E  R +  L   +A R ELE ++ + L E+  +     +A    L + E
Sbjct: 844  EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKN-DLQLQVQAEQDNLADAE 902

Query: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGP 1120
             +  +L          IK   +L   VK++ E+L  +E+ +A                  
Sbjct: 903  ERCDQL----------IKNKIQLEAKVKEMNERLEDEEEMNAE----------------- 935

Query: 1121 KLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGH 1180
                L A+  KLE +C + +   D LE +L       A+ +      + +++   +E+  
Sbjct: 936  ----LTAKKRKLEDECSELKRDIDDLELTL-------AKVEKEKHATENKVKNLTEEMAG 984

Query: 1181 SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ 1240
                +A   +E  A +   + H +A D+ +A       E ++ N+L  +  +    L +Q
Sbjct: 985  LDEIIAKLTKEKKALQ---EAHQQALDDLQA-------EEDKVNTLTKAKVK----LEQQ 1030

Query: 1241 VLEKEGESKELKRLVMAESEKSQKLEERLRLLQA---ETASNSARAAERSSALREEVQSL 1297
            V + EG  ++ K++ M      +KLE  L+L Q    +  ++  +  ER      E+ +L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
                E ++     L+++L     R EEL +EL+A +    + E+  S L  E       +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150

Query: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELE----QSKQAAGGLRAELLRAQRELGELIPLR 1413
             E   A  +  ++  ++ A  ++ R +LE    Q +  A  LR +   +  ELGE I   
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210

Query: 1414 QKVAEQ-ERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA 1472
            Q+V ++ E+   + + E       +  + KA   L +  R L ++ N  R   E      
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE-----E 1265

Query: 1473 REKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK 1532
             ++ V +L + RA  +T   E+ R+       +  +T                    R K
Sbjct: 1266 TQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT--------------------RGK 1305

Query: 1533 LTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592
            LT   +QLE  +R+  ++V+     LA + Q+++     L+    +  E++ E QR+ ++
Sbjct: 1306 LT-YTQQLEDLKRQLEEEVKA-KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSK 1363

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA 1652
             N   AQ                  +T Y+          + ++  E+L++  K+L    
Sbjct: 1364 ANSEVAQW-----------------RTKYET---------DAIQRTEELEEAKKKLAQRL 1397

Query: 1653 ERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREP 1712
            +     ++    K    E+T   L  ++  L   V  ++     L K Q   D + +   
Sbjct: 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--- 1454

Query: 1713 QAKPQLDLSIDSLDLSCEEGTPLS 1736
            + K + + S   L+ S +E   LS
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLS 1478



 Score = 38.9 bits (89), Expect = 0.054
 Identities = 30/128 (23%), Positives = 60/128 (46%), Gaps = 10/128 (7%)

Query: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ 1660
            +++E+     K +  + K   +  + + +EL+E++ SL Q +K + +L+ +AE+      
Sbjct: 843  AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ-EKNDLQLQVQAEQDN---- 897

Query: 1661 QAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDL 1720
                   +AE+ C  L      LEA+V   +++L D  +      A K +      +L  
Sbjct: 898  -----LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKR 952

Query: 1721 SIDSLDLS 1728
             ID L+L+
Sbjct: 953  DIDDLELT 960


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  210 bits (535), Expect = 1e-53
 Identities = 304/1255 (24%), Positives = 521/1255 (41%), Gaps = 187/1255 (14%)

Query: 379  KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
            ++E+LQ +  +L++ + +LQ    +E GE+ G V QLE   +E A LA    QL+A  E+
Sbjct: 875  QDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLE---EERARLAE---QLRAEAEL 927

Query: 439  LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498
                     A+    RG     KQ+L  ++++L++ +      +EE  +  Q    RL  
Sbjct: 928  C--------AEAEETRGRLAARKQELELVVSELEARVGE----EEECSRQMQTEKKRLQQ 975

Query: 499  QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS 558
             +  L + L       Q+   E    K   + K  +  + L   E  +  L  + + L  
Sbjct: 976  HIQELEAHLEAEEGARQKLQLE----KVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED 1031

Query: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
             L +   Q  E  EK ++  +   +  AT A+  E  LR+ +   ++LE L++    +  
Sbjct: 1032 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD-MEDRLRKEEKGRQELEKLKRRLDGESS 1090

Query: 619  ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ----------HE 668
             LQ+Q+    +          +A+  +A+L RK EELQA +  A  E            E
Sbjct: 1091 ELQEQMVEQQQ----------RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLRE 1140

Query: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
            AQA +A        E Q+  E ERVA+ K   ++Q + L E L+  +G LE+      D+
Sbjct: 1141 AQAALA--------EAQEDLESERVARTK--AEKQRRDLGEELEALRGELED----TLDS 1186

Query: 729  LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
               QQ        E RS  EQ   E K+  EE       E R+      H+A  + LR+ 
Sbjct: 1187 TNAQQ--------ELRSKREQEVTELKKTLEE-------ETRI------HEAAVQELRQR 1225

Query: 789  LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
              +A+        + EQ  +   AW +     + E ++  A     L T ++E E+ R+ 
Sbjct: 1226 HGQALG---ELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL-SSLQTARQEGEQRRRR 1281

Query: 849  LQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEK 908
            L              ELQ+   Q    +     A A +++Q  +   + ++  L+  + K
Sbjct: 1282 L--------------ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1327

Query: 909  MAATSKEVARLETLVRKAGE--QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA 966
                SKE++  E  +  A E  Q+ET ++  +    RA + +   L EQ           
Sbjct: 1328 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ----------- 1376

Query: 967  LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE--REVARLTQERGRAQADLALEK 1024
            L+      E+ G EL+  +A L E + +Q+EE G  E   E  R       A      EK
Sbjct: 1377 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436

Query: 1025 AARAEL----EMRLQNALNEQRVEFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKE 1079
                +       RLQ  L++  ++    Q  L   L +K+ K DQ LA+ +   AA ++ 
Sbjct: 1437 TETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEEK---AAVLRA 1492

Query: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
            +EE  +   + +E    +E    S + A  E     E    +  ALRAE+  L       
Sbjct: 1493 VEERERAEAEGRE----REARALSLTRALEEEQEAREELERQNRALRAELEAL------- 1541

Query: 1140 QEQADSLERSL-EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTK 1198
                D + +S+ E ERA R   + A   L+ Q+ E   EL  ++ A    +  + A +T+
Sbjct: 1542 LSSKDDVGKSVHELERACRV-AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1600

Query: 1199 ----VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254
                +Q   +A +E + Q+A+  ++AE +       +  +++  R+ L  EGE +ELK  
Sbjct: 1601 HERDLQGRDEAGEERRRQLAKQLRDAEVERD-EERKQRTLAVAARKKL--EGELEELKAQ 1657

Query: 1255 VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK--QRVASENLR 1312
            + +  +  ++  ++LR +QA+      R  E +   REE+ S   E+EK  + + +E LR
Sbjct: 1658 MASAGQGKEEAVKQLRKMQAQ-MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1716

Query: 1313 -QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ 1371
             QE  + ++RA    Q+          +++    +   + S  A++ E        +QL+
Sbjct: 1717 LQEELAASDRARRQAQQ---------DRDEMADEVANGNLSKAAILEEK-------RQLE 1760

Query: 1372 AEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKA 1431
                  E+   EE   S+      R  LL+ +    EL   R   A+ E   QQL  +  
Sbjct: 1761 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ-- 1818

Query: 1432 SYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL------AAVRA 1485
                    +++  G L EE+ G   R  +    LE +L QA E+  QE         +  
Sbjct: 1819 --------IQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1870

Query: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----------EERQRFQEERQKLTA 1535
             AE RL EV  + +   R  + +  + E   ++V           EE  R Q  R++L  
Sbjct: 1871 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930

Query: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
            ++E +        ++V  L  +L         +  +      +G  S +EA+  Q
Sbjct: 1931 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985



 Score =  200 bits (509), Expect = 1e-50
 Identities = 307/1413 (21%), Positives = 599/1413 (42%), Gaps = 200/1413 (14%)

Query: 392  EHLSQLQDNPP--QEKGEVLGDVLQL--ETLKQEAATLAANNTQ-LQARVEMLETERGQQ 446
            E +S L D PP  + +  +   V QL  E+L +  ATL+  N   ++  V   E   G+ 
Sbjct: 656  EQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKL 715

Query: 447  EAKLLAE--------------------RGHFEEEKQQLSSLITD-LQSSISNLSQAKEEL 485
            E +L+ +                    R  F+E +Q+   L  + +     +  QA E++
Sbjct: 716  EPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKM 775

Query: 486  EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL--KQQAKEKQAQLAQTLQQQE 543
             QA +          + +      L    +++D ++  +    QA  +     +  Q+++
Sbjct: 776  IQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQ 835

Query: 544  QASQGLRHQVEQLSSSLKQKEQQ----LKEVAEKQEATRQDH-----AQQLATAAEEREA 594
            Q    LR      ++ LK +  Q      +V    + TRQD      AQ+L    E ++ 
Sbjct: 836  QQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQ 895

Query: 595  SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK---AELSRK 651
            S RE      ++  LE+E+A   E L+ + ++  EA ++      + Q  +   +EL  +
Sbjct: 896  SAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR 955

Query: 652  VEELQACVETARQEQHEAQAQVAELELQLRSEQ--------QKATEKERVAQEKDQ---L 700
            V E + C    + E+   Q  + ELE  L +E+        +K T + ++ + ++    L
Sbjct: 956  VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1015

Query: 701  QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
            ++Q   L +  K+ +  L E   +AA+  EE+ + +++L+ +  + +   +     L +E
Sbjct: 1016 EDQNSKLSKERKLLEDRLAEFSSQAAEE-EEKVKSLNKLRLKYEATIADME---DRLRKE 1071

Query: 761  RAGRKGLEARLQQL-GEAHQAETEVL-RRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
              GR+ LE   ++L GE+ + + +++ +++ AE + AQ   + E      E+ A   R E
Sbjct: 1072 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE------ELQAALARAE 1125

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            D     A        QL+    E + A  E QE  E      + +E Q      EL  L 
Sbjct: 1126 DEGGARA--------QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALR 1177

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L   L              D  +  QE  +   +EV  L+  + +     E A +EL 
Sbjct: 1178 GELEDTL--------------DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1223

Query: 939  KEPARAGDRQPEWLEE-QQGR-QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
            +   +A     E LE+ ++G+  +  T+ AL+A          E+  LRA L   Q  +Q
Sbjct: 1224 QRHGQALGELAEQLEQARRGKGAWEKTRLALEA----------EVSELRAELSSLQTARQ 1273

Query: 997  EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
            E   ++ R   +L + +GRA       + ARAE   +LQ A  E         E ++ AL
Sbjct: 1274 EGEQRRRRLELQLQEVQGRAGDG----ERARAEAAEKLQRAQAE--------LENVSGAL 1321

Query: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK----EKEHASGSGAQSEAA 1112
             E E K   L+K      AQ+ + +EL Q   + K  L  +    E E A       E A
Sbjct: 1322 NEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEA 1381

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE------- 1165
               E  G +L+  +A++S+     ++Q+E+A +LE   EA R +  E ++  +       
Sbjct: 1382 AARERAGRELQTAQAQLSEWR---RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE 1438

Query: 1166 ----------TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHS----KAEDEWKA 1211
                       LQ +L++   +L   +  +++ +++   F   + +      +A +E + 
Sbjct: 1439 TVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERER 1498

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGES--KELKRLVMAESEKSQKLEERL 1269
              A GR+   R  SL  +LEEE     R+ LE++  +   EL+ L+ ++ +  + + E  
Sbjct: 1499 AEAEGREREARALSLTRALEEEQEA--REELERQNRALRAELEALLSSKDDVGKSVHELE 1556

Query: 1270 RLLQ-AETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
            R  + AE A+N  RA  + + L +E+ +  +   +  V  + L+ +     +  +E G+E
Sbjct: 1557 RACRVAEQAANDLRA--QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE 1614

Query: 1329 -----LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
                  K  ++   ++++      L   + + L  EL       ++L+A+ A+A +   E
Sbjct: 1615 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL-------EELKAQMASAGQGKEE 1667

Query: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ----LRAEKASYAEQLSM 1439
             ++Q ++    ++A++    RE+ E    R+++  Q R +++    L AE     E+L+ 
Sbjct: 1668 AVKQLRK----MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1723

Query: 1440 LKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499
              +A     ++   + +    G       L++ R+             E RL +++ E +
Sbjct: 1724 SDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQ------------LEGRLGQLEEELE 1771

Query: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
                  E++  +Y    ++V         ER   +A+ E     +++  +Q++EL  +L 
Sbjct: 1772 EEQSNSELLNDRYRKLLLQVESLTTELSAER-SFSAKAES---GRQQLERQIQELRGRLG 1827

Query: 1560 DSDQASKVQQQ------KLKAVQAQGGESQQEAQRL---------QAQLNELQAQLSQKE 1604
            + D  ++ + +      + K  QA+    Q+  +R+         + +L E+  Q+ ++ 
Sbjct: 1828 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1887

Query: 1605 QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKELRAEAERLGHELQ 1660
            + A+  + Q+EK        K+Q +E +E+    +    +LQ+E +++   AE +  E+ 
Sbjct: 1888 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1947

Query: 1661 QAGLKTKEAEQTCRHLTA-QVRSLEAQVAHADQ 1692
                + +    T    T  QV  LE  VA  ++
Sbjct: 1948 TLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1980



 Score =  198 bits (504), Expect = 4e-50
 Identities = 284/1172 (24%), Positives = 485/1172 (41%), Gaps = 176/1172 (15%)

Query: 242  KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE----ELRDKNESLTMRLHETLK 297
            K L +   Q  ++Q R   L  + E Q  S  E  EL+    +L ++   L  +L    +
Sbjct: 867  KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 926

Query: 298  QCQD-------LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK 350
             C +       L   K +++  +++L    G+     R+  +  ++LQ  + EL E H +
Sbjct: 927  LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQEL-EAHLE 985

Query: 351  ATQEWLEKQAQLEKELSAAL-----QDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405
            A +E   ++ QLEK  + A      +D   LE++N  L  +   LE+ L++      +E+
Sbjct: 986  A-EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1044

Query: 406  GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS 465
             +V    L    LK E AT+A    +L+      + E+G+QE          E+ K++L 
Sbjct: 1045 EKVKS--LNKLRLKYE-ATIADMEDRLR------KEEKGRQE---------LEKLKRRLD 1086

Query: 466  SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525
               ++LQ  +    Q  EEL            AQ+     EL    A  + +    A L 
Sbjct: 1087 GESSELQEQMVEQQQRAEELR-----------AQLGRKEEELQAALARAEDEGGARAQLL 1135

Query: 526  QQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK---QEATRQ 579
            +  +E QA LA+    L+ +  A      Q   L   L+    +L++  +    Q+  R 
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195

Query: 580  DHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
               Q++    +  E   R  +AA+++   L +     L  L +QL+ A   + + + +  
Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQE---LRQRHGQALGELAEQLEQARRGKGAWEKTRL 1252

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
              + E +EL  ++  LQ    TARQE  + + +   LELQL+  Q +A + ER   E   
Sbjct: 1253 ALEAEVSELRAELSSLQ----TARQEGEQRRRR---LELQLQEVQGRAGDGERARAE--- 1302

Query: 700  LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
              E+LQ  +  L+   G+L E + +              L  E  S   Q    ++ L+E
Sbjct: 1303 AAEKLQRAQAELENVSGALNEAESKTI-----------RLSKELSSTEAQLHDAQELLQE 1351

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
            E   +  L +R++    A +AE   LR +L E  AA+  A  E +    +++ WR R   
Sbjct: 1352 ETRAKLALGSRVR----AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR--- 1404

Query: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879
             Q+EEA      +E       E E   Q L E  E V  +E        R Q EL +   
Sbjct: 1405 -QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR----RLQQELDDATM 1459

Query: 880  NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
            +L +  Q V              STL++K     + +A  +  V +A E++E A  E  +
Sbjct: 1460 DLEQQRQLV--------------STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1505

Query: 940  EPARAGDRQPEWLEEQQGRQFCSTQ-----AALQAMEREAEQMGNELERLRAALMESQGQ 994
              ARA        EEQ+ R+    Q     A L+A+    + +G  +  L  A   ++  
Sbjct: 1506 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1565

Query: 995  QQEERGQQEREVARLTQERGRAQ-ADLALEKAARA-----ELEMRLQNALNEQRVEFATL 1048
              + R Q    V  L  E   A+ A L LE   +A     E +++ ++   E+R      
Sbjct: 1566 ANDLRAQ----VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER------ 1615

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIK----ELEELR-----------QTVKQLKEQ 1093
            +  LA  L + E +  E  K R L  A  K    ELEEL+           + VKQL++ 
Sbjct: 1616 RRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKM 1675

Query: 1094 LAKKE---KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC-----------QKQ 1139
             A+ +   +E      ++ E   +   +  +L+ L AEV +L+++            Q +
Sbjct: 1676 QAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1735

Query: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
             E AD +       +A+  E    LE   GQLEE+ +E   +   L    R+L      +
Sbjct: 1736 DEMADEVANG-NLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1794

Query: 1200 QDHSKAEDEWKAQVARGRQEAERK-NSLISSLEEE-----------VSILNRQVLEKEGE 1247
                 AE  + A+   GRQ+ ER+   L   L EE           ++ L  ++ + E +
Sbjct: 1795 TTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1854

Query: 1248 SKELKRLVMAESEKSQKLEERLR--LLQAETASNSA--------RAAERSSALREEVQSL 1297
             ++  R  +   +  ++ E+RL+  +LQ E     A        +   R   L+ +++  
Sbjct: 1855 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEA 1914

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQEL 1329
             EEA + +     L++EL    E AE + +E+
Sbjct: 1915 EEEASRAQAGRRRLQRELEDVTESAESMNREV 1946



 Score =  191 bits (484), Expect = 8e-48
 Identities = 260/1074 (24%), Positives = 471/1074 (43%), Gaps = 134/1074 (12%)

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
            +V ++ + LQ + Q L++        ++E ++++A  + E Q  +++L+ E   L EQ +
Sbjct: 871  QVTRQDEVLQARAQELQK--------VQELQQQSAREVGELQGRVAQLEEERARLAEQLR 922

Query: 752  RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
             E +   E    R  L AR Q+L E   +E E    E  E      T +   +Q ++E+ 
Sbjct: 923  AEAELCAEAEETRGRLAARKQEL-ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 981

Query: 812  AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871
            A  E  E ++Q+        Q + +T + + +K  ++L   +++ + +    +L     +
Sbjct: 982  AHLEAEEGARQK-------LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLL----E 1030

Query: 872  NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931
            + LAE  +  A   ++V+       K    ++ +++++    K    LE L R+   +  
Sbjct: 1031 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1090

Query: 932  TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLR---AAL 988
                ++V++  RA     E L  Q GR+    QAAL   E E       L+ LR   AAL
Sbjct: 1091 ELQEQMVEQQQRA-----EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1145

Query: 989  MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
             E+Q   + ER      VAR   E+ R      LE A R ELE  L +   +Q +     
Sbjct: 1146 AEAQEDLESER------VARTKAEKQRRDLGEELE-ALRGELEDTLDSTNAQQELRSKRE 1198

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
            QE     +TE +   +E  ++   EAA    ++ELRQ   Q   +LA++ ++   G GA 
Sbjct: 1199 QE-----VTELKKTLEEETRIH--EAA----VQELRQRHGQALGELAEQLEQARRGKGAW 1247

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE--------AERASRAER 1160
             +     E    ++  LRAE+S L+   Q+ +++   LE  L+         ERA RAE 
Sbjct: 1248 EKTRLALEA---EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA-RAEA 1303

Query: 1161 DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA-EDEWKAQVARGRQE 1219
               L+  Q +LE  +  L  ++S      +EL++   ++ D  +  ++E +A++A G   
Sbjct: 1304 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG--- 1360

Query: 1220 AERKNSLISSLEEEVSILNRQVLE----KEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275
                 S + ++E E + L  Q+ E    +E   +EL+      SE  ++ EE    L+A 
Sbjct: 1361 -----SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG 1415

Query: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL---TSQAERAEELGQELKAW 1332
              +   RAA  + AL + +    E  ++       L+QEL   T   E+  +L   L+  
Sbjct: 1416 EEARR-RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKK 1474

Query: 1333 QEKFFQ-----KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQ 1387
            Q KF Q     K   L  ++    +          A  L + L+ EQ A     REELE+
Sbjct: 1475 QRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA-----REELER 1529

Query: 1388 SKQAAGGLRAELLRAQRELGELI-PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGL 1446
              +A       LL ++ ++G+ +  L +     E+ A  LRA+     ++L+  + A   
Sbjct: 1530 QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR 1589

Query: 1447 LAEENRGLG---ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR 1503
            L    + L    ER   GR       D+A E+  ++LA      + R AEV+R+ +   R
Sbjct: 1590 LEVTVQALKTQHERDLQGR-------DEAGEERRRQLAK-----QLRDAEVERDEERKQR 1637

Query: 1504 ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQ 1563
             L V               R++ + E ++L AQ+      + E  KQ+ ++  ++ +  +
Sbjct: 1638 TLAVAA-------------RKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1684

Query: 1564 ASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA---AEHYKLQMEKAKTH 1620
              +  +   + + +Q  ES++  + L+A++  LQ +L+  ++A   A+  + +M     +
Sbjct: 1685 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1744

Query: 1621 YDAKK---------------QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLK 1665
             +  K               Q  +EL+E+  + E L    ++L  + E L  EL      
Sbjct: 1745 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1804

Query: 1666 TKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
            + +AE   + L  Q++ L  ++   D   R   K  +A  AL+S+  QA+ QL+
Sbjct: 1805 SAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIA--ALESKLAQAEEQLE 1856



 Score =  156 bits (394), Expect = 2e-37
 Identities = 225/952 (23%), Positives = 404/952 (42%), Gaps = 134/952 (14%)

Query: 865  LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
            LQ++RQ   L       A+ LQ+VQE +   Q+ A ++  LQ ++A   +E ARL   +R
Sbjct: 870  LQVTRQDEVLQAR----AQELQKVQELQ---QQSAREVGELQGRVAQLEEERARLAEQLR 922

Query: 925  K----AGEQQETASR--------ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
                   E +ET  R        ELV     A   + E    Q   +    Q  +Q +E 
Sbjct: 923  AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEA 982

Query: 973  --EAEQMGNELERLRAALMESQGQQ-QEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
              EAE+   +  +L     E++ ++ +E+    E + ++L++ER   +  LA   +  AE
Sbjct: 983  HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1042

Query: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL----RQ 1085
             E ++++ LN+ R+++      +   L ++E   QEL KL+     +  EL+E     +Q
Sbjct: 1043 EEEKVKS-LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1101

Query: 1086 TVKQLKEQLAKKEKE-HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
              ++L+ QL +KE+E  A+ + A+ E   R +     L++LR      E Q    + Q D
Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQ----LLKSLR------EAQAALAEAQED 1151

Query: 1145 SLERSLEAERASRAERD--SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
                 +   +A +  RD    LE L+G+LE+        Q   +  ++E+   +  +   
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL--- 1208

Query: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV-------LEKEGESKELKRLV 1255
               E+E +   A  ++  +R    +  L E++    R         L  E E  EL+  +
Sbjct: 1209 ---EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1265

Query: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL 1315
             +     Q+ E+R R L+ +      RA +   A  E  + L    ++ +   EN+   L
Sbjct: 1266 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL----QRAQAELENVSGAL 1321

Query: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQA 1375
                 +   L +EL + +    Q   A   LQ E  +  AL S +       + ++AE A
Sbjct: 1322 NEAESKTIRLSKELSSTEA---QLHDAQELLQEETRAKLALGSRV-------RAMEAEAA 1371

Query: 1376 AAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAE 1435
                  RE+LE+   A      EL  AQ +L E    +++ A      ++ R   A  AE
Sbjct: 1372 GL----REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1427

Query: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA----------------REKYVQE 1479
             L+        LAE+   + +R   GR+ L+ ELD A                +++   +
Sbjct: 1428 ALTQR------LAEKTETV-DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQ 1480

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            L A    A  R  E +  A++  RE E        A  +  E R+  + + + L A++E 
Sbjct: 1481 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1540

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
            L   + +  K V EL +    ++QA+   + ++  ++ +   ++    RL+  +  L+ Q
Sbjct: 1541 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1600

Query: 1600 ----LSQKEQAAEHYKLQMEK----AKTHYD-----------AKKQQNQEL--------- 1631
                L  +++A E  + Q+ K    A+   D           A+K+   EL         
Sbjct: 1601 HERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1660

Query: 1632 -----QEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686
                 +E ++ L ++Q + KEL  E E      ++   + +E+E+  + L A+V  L+ +
Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1720

Query: 1687 VAHAD------QQLRDLGKFQVATDAL-KSREPQAKPQLDLSIDSLDLSCEE 1731
            +A +D      QQ RD    +VA   L K+   + K QL+  +  L+   EE
Sbjct: 1721 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1772



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 61/283 (21%), Positives = 130/283 (45%), Gaps = 40/283 (14%)

Query: 1468 ELDQAREKYVQEL-----AAVRADAETRLAEVQREAQSTARELEVMTAKYEG-------- 1514
            +L++ R+  V ++     AA R     R  + +++ QS  R ++   A Y          
Sbjct: 802  QLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWR 861

Query: 1515 --AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
               KVK L +  R  E  Q    ++++++  Q++  ++V EL  ++A  ++      ++L
Sbjct: 862  LFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQL 921

Query: 1573 KAVQAQGGESQQEAQRLQAQ-------LNELQAQLSQKEQAA-----EHYKLQ--MEKAK 1618
            +A      E+++   RL A+       ++EL+A++ ++E+ +     E  +LQ  +++ +
Sbjct: 922  RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 981

Query: 1619 THYDAKKQQNQELQ-------EQLRSLEQ----LQKENKELRAEAERLGHELQQAGLKTK 1667
             H +A++   Q+LQ        +++  E+    L+ +N +L  E + L   L +   +  
Sbjct: 982  AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAA 1041

Query: 1668 EAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSR 1710
            E E+  + L       EA +A  + +LR   K +   + LK R
Sbjct: 1042 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRR 1084



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 75/349 (21%), Positives = 152/349 (43%), Gaps = 43/349 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
            L+  Q QM+ L +++ + R++R+E+  +  E+ K L   +A++  +Q          E+ 
Sbjct: 1672 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ----------EEL 1721

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
            AAS    ++ ++  D++E      +  L +   L+ EK Q++ ++ QL EE       L 
Sbjct: 1722 AASDRARRQAQQ--DRDEMADEVANGNLSKAAILE-EKRQLEGRLGQLEEE-------LE 1771

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA-ALQDKKCLEEKNEILQGKL 387
            E  S+ + L D   +L  +    T E        E+  SA A   ++ LE + + L+G+L
Sbjct: 1772 EEQSNSELLNDRYRKLLLQVESLTTE-----LSAERSFSAKAESGRQQLERQIQELRGRL 1826

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
             +             ++ G      + +  L+ + A  A    + + R  +L  +  ++ 
Sbjct: 1827 GE-------------EDAGARARHKMTIAALESKLAQ-AEEQLEQETRERILSGKLVRRA 1872

Query: 448  AKLLAERG-HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
             K L E     EEE++    L   L+     + Q K +LE+A +   +R  A    L  E
Sbjct: 1873 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE-EASRAQAGRRRLQRE 1931

Query: 507  LTTLNATIQQQDQELAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVE 554
            L  +  + +  ++E+  L+ + +        +T++Q  +  +G+    E
Sbjct: 1932 LEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1980



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 12/111 (10%)

Query: 1626 QQNQELQEQ-LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
            Q+ QELQ+Q  R + +LQ    +L  E  RL  +L+       EAE+T   L A+ + LE
Sbjct: 887  QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELE 946

Query: 1685 AQVAHADQQLRDLGKFQVATDALKSREPQA-KPQLDLSIDSLD--LSCEEG 1732
              V+  +         +V  +   SR+ Q  K +L   I  L+  L  EEG
Sbjct: 947  LVVSELEA--------RVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 989



 Score = 32.3 bits (72), Expect = 5.1
 Identities = 27/128 (21%), Positives = 59/128 (46%), Gaps = 6/128 (4%)

Query: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
            Q  Q++Q+A   ++       +   +  Q   L  +++ L Q+ ++++ L+A A+    E
Sbjct: 832  QKRQQQQSA--LRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQ----E 885

Query: 1659 LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQL 1718
            LQ+     +++ +    L  +V  LE + A   +QLR   +     +  + R    K +L
Sbjct: 886  LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 945

Query: 1719 DLSIDSLD 1726
            +L +  L+
Sbjct: 946  ELVVSELE 953


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  210 bits (535), Expect = 1e-53
 Identities = 304/1255 (24%), Positives = 521/1255 (41%), Gaps = 187/1255 (14%)

Query: 379  KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
            ++E+LQ +  +L++ + +LQ    +E GE+ G V QLE   +E A LA    QL+A  E+
Sbjct: 867  QDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLE---EERARLAE---QLRAEAEL 919

Query: 439  LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498
                     A+    RG     KQ+L  ++++L++ +      +EE  +  Q    RL  
Sbjct: 920  C--------AEAEETRGRLAARKQELELVVSELEARVGE----EEECSRQMQTEKKRLQQ 967

Query: 499  QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS 558
             +  L + L       Q+   E    K   + K  +  + L   E  +  L  + + L  
Sbjct: 968  HIQELEAHLEAEEGARQKLQLE----KVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED 1023

Query: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
             L +   Q  E  EK ++  +   +  AT A+  E  LR+ +   ++LE L++    +  
Sbjct: 1024 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD-MEDRLRKEEKGRQELEKLKRRLDGESS 1082

Query: 619  ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ----------HE 668
             LQ+Q+    +          +A+  +A+L RK EELQA +  A  E            E
Sbjct: 1083 ELQEQMVEQQQ----------RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLRE 1132

Query: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
            AQA +A        E Q+  E ERVA+ K   ++Q + L E L+  +G LE+      D+
Sbjct: 1133 AQAALA--------EAQEDLESERVARTK--AEKQRRDLGEELEALRGELED----TLDS 1178

Query: 729  LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
               QQ        E RS  EQ   E K+  EE       E R+      H+A  + LR+ 
Sbjct: 1179 TNAQQ--------ELRSKREQEVTELKKTLEE-------ETRI------HEAAVQELRQR 1217

Query: 789  LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
              +A+        + EQ  +   AW +     + E ++  A     L T ++E E+ R+ 
Sbjct: 1218 HGQALG---ELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL-SSLQTARQEGEQRRRR 1273

Query: 849  LQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEK 908
            L              ELQ+   Q    +     A A +++Q  +   + ++  L+  + K
Sbjct: 1274 L--------------ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1319

Query: 909  MAATSKEVARLETLVRKAGE--QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA 966
                SKE++  E  +  A E  Q+ET ++  +    RA + +   L EQ           
Sbjct: 1320 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ----------- 1368

Query: 967  LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE--REVARLTQERGRAQADLALEK 1024
            L+      E+ G EL+  +A L E + +Q+EE G  E   E  R       A      EK
Sbjct: 1369 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1428

Query: 1025 AARAEL----EMRLQNALNEQRVEFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKE 1079
                +       RLQ  L++  ++    Q  L   L +K+ K DQ LA+ +   AA ++ 
Sbjct: 1429 TETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEEK---AAVLRA 1484

Query: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
            +EE  +   + +E    +E    S + A  E     E    +  ALRAE+  L       
Sbjct: 1485 VEERERAEAEGRE----REARALSLTRALEEEQEAREELERQNRALRAELEAL------- 1533

Query: 1140 QEQADSLERSL-EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTK 1198
                D + +S+ E ERA R   + A   L+ Q+ E   EL  ++ A    +  + A +T+
Sbjct: 1534 LSSKDDVGKSVHELERACRV-AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1592

Query: 1199 ----VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254
                +Q   +A +E + Q+A+  ++AE +       +  +++  R+ L  EGE +ELK  
Sbjct: 1593 HERDLQGRDEAGEERRRQLAKQLRDAEVERD-EERKQRTLAVAARKKL--EGELEELKAQ 1649

Query: 1255 VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK--QRVASENLR 1312
            + +  +  ++  ++LR +QA+      R  E +   REE+ S   E+EK  + + +E LR
Sbjct: 1650 MASAGQGKEEAVKQLRKMQAQ-MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1708

Query: 1313 -QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ 1371
             QE  + ++RA    Q+          +++    +   + S  A++ E        +QL+
Sbjct: 1709 LQEELAASDRARRQAQQ---------DRDEMADEVANGNLSKAAILEEK-------RQLE 1752

Query: 1372 AEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKA 1431
                  E+   EE   S+      R  LL+ +    EL   R   A+ E   QQL  +  
Sbjct: 1753 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ-- 1810

Query: 1432 SYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL------AAVRA 1485
                    +++  G L EE+ G   R  +    LE +L QA E+  QE         +  
Sbjct: 1811 --------IQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862

Query: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----------EERQRFQEERQKLTA 1535
             AE RL EV  + +   R  + +  + E   ++V           EE  R Q  R++L  
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922

Query: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
            ++E +        ++V  L  +L         +  +      +G  S +EA+  Q
Sbjct: 1923 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977



 Score =  200 bits (509), Expect = 1e-50
 Identities = 307/1413 (21%), Positives = 599/1413 (42%), Gaps = 200/1413 (14%)

Query: 392  EHLSQLQDNPP--QEKGEVLGDVLQL--ETLKQEAATLAANNTQ-LQARVEMLETERGQQ 446
            E +S L D PP  + +  +   V QL  E+L +  ATL+  N   ++  V   E   G+ 
Sbjct: 648  EQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKL 707

Query: 447  EAKLLAE--------------------RGHFEEEKQQLSSLITD-LQSSISNLSQAKEEL 485
            E +L+ +                    R  F+E +Q+   L  + +     +  QA E++
Sbjct: 708  EPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKM 767

Query: 486  EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL--KQQAKEKQAQLAQTLQQQE 543
             QA +          + +      L    +++D ++  +    QA  +     +  Q+++
Sbjct: 768  IQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQ 827

Query: 544  QASQGLRHQVEQLSSSLKQKEQQ----LKEVAEKQEATRQDH-----AQQLATAAEEREA 594
            Q    LR      ++ LK +  Q      +V    + TRQD      AQ+L    E ++ 
Sbjct: 828  QQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQ 887

Query: 595  SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK---AELSRK 651
            S RE      ++  LE+E+A   E L+ + ++  EA ++      + Q  +   +EL  +
Sbjct: 888  SAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR 947

Query: 652  VEELQACVETARQEQHEAQAQVAELELQLRSEQ--------QKATEKERVAQEKDQ---L 700
            V E + C    + E+   Q  + ELE  L +E+        +K T + ++ + ++    L
Sbjct: 948  VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1007

Query: 701  QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
            ++Q   L +  K+ +  L E   +AA+  EE+ + +++L+ +  + +   +     L +E
Sbjct: 1008 EDQNSKLSKERKLLEDRLAEFSSQAAEE-EEKVKSLNKLRLKYEATIADME---DRLRKE 1063

Query: 761  RAGRKGLEARLQQL-GEAHQAETEVL-RRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
              GR+ LE   ++L GE+ + + +++ +++ AE + AQ   + E      E+ A   R E
Sbjct: 1064 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE------ELQAALARAE 1117

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            D     A        QL+    E + A  E QE  E      + +E Q      EL  L 
Sbjct: 1118 DEGGARA--------QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALR 1169

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L   L              D  +  QE  +   +EV  L+  + +     E A +EL 
Sbjct: 1170 GELEDTL--------------DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1215

Query: 939  KEPARAGDRQPEWLEE-QQGR-QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
            +   +A     E LE+ ++G+  +  T+ AL+A          E+  LRA L   Q  +Q
Sbjct: 1216 QRHGQALGELAEQLEQARRGKGAWEKTRLALEA----------EVSELRAELSSLQTARQ 1265

Query: 997  EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
            E   ++ R   +L + +GRA       + ARAE   +LQ A  E         E ++ AL
Sbjct: 1266 EGEQRRRRLELQLQEVQGRAGDG----ERARAEAAEKLQRAQAE--------LENVSGAL 1313

Query: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK----EKEHASGSGAQSEAA 1112
             E E K   L+K      AQ+ + +EL Q   + K  L  +    E E A       E A
Sbjct: 1314 NEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEA 1373

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE------- 1165
               E  G +L+  +A++S+     ++Q+E+A +LE   EA R +  E ++  +       
Sbjct: 1374 AARERAGRELQTAQAQLSEWR---RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE 1430

Query: 1166 ----------TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHS----KAEDEWKA 1211
                       LQ +L++   +L   +  +++ +++   F   + +      +A +E + 
Sbjct: 1431 TVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERER 1490

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGES--KELKRLVMAESEKSQKLEERL 1269
              A GR+   R  SL  +LEEE     R+ LE++  +   EL+ L+ ++ +  + + E  
Sbjct: 1491 AEAEGREREARALSLTRALEEEQEA--REELERQNRALRAELEALLSSKDDVGKSVHELE 1548

Query: 1270 RLLQ-AETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
            R  + AE A+N  RA  + + L +E+ +  +   +  V  + L+ +     +  +E G+E
Sbjct: 1549 RACRVAEQAANDLRA--QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE 1606

Query: 1329 -----LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
                  K  ++   ++++      L   + + L  EL       ++L+A+ A+A +   E
Sbjct: 1607 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL-------EELKAQMASAGQGKEE 1659

Query: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ----LRAEKASYAEQLSM 1439
             ++Q ++    ++A++    RE+ E    R+++  Q R +++    L AE     E+L+ 
Sbjct: 1660 AVKQLRK----MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1715

Query: 1440 LKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499
              +A     ++   + +    G       L++ R+             E RL +++ E +
Sbjct: 1716 SDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQ------------LEGRLGQLEEELE 1763

Query: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
                  E++  +Y    ++V         ER   +A+ E     +++  +Q++EL  +L 
Sbjct: 1764 EEQSNSELLNDRYRKLLLQVESLTTELSAER-SFSAKAES---GRQQLERQIQELRGRLG 1819

Query: 1560 DSDQASKVQQQ------KLKAVQAQGGESQQEAQRL---------QAQLNELQAQLSQKE 1604
            + D  ++ + +      + K  QA+    Q+  +R+         + +L E+  Q+ ++ 
Sbjct: 1820 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1879

Query: 1605 QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKELRAEAERLGHELQ 1660
            + A+  + Q+EK        K+Q +E +E+    +    +LQ+E +++   AE +  E+ 
Sbjct: 1880 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1939

Query: 1661 QAGLKTKEAEQTCRHLTA-QVRSLEAQVAHADQ 1692
                + +    T    T  QV  LE  VA  ++
Sbjct: 1940 TLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1972



 Score =  198 bits (504), Expect = 4e-50
 Identities = 284/1172 (24%), Positives = 485/1172 (41%), Gaps = 176/1172 (15%)

Query: 242  KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE----ELRDKNESLTMRLHETLK 297
            K L +   Q  ++Q R   L  + E Q  S  E  EL+    +L ++   L  +L    +
Sbjct: 859  KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 918

Query: 298  QCQD-------LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK 350
             C +       L   K +++  +++L    G+     R+  +  ++LQ  + EL E H +
Sbjct: 919  LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQEL-EAHLE 977

Query: 351  ATQEWLEKQAQLEKELSAAL-----QDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405
            A +E   ++ QLEK  + A      +D   LE++N  L  +   LE+ L++      +E+
Sbjct: 978  A-EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1036

Query: 406  GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS 465
             +V    L    LK E AT+A    +L+      + E+G+QE          E+ K++L 
Sbjct: 1037 EKVKS--LNKLRLKYE-ATIADMEDRLR------KEEKGRQE---------LEKLKRRLD 1078

Query: 466  SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525
               ++LQ  +    Q  EEL            AQ+     EL    A  + +    A L 
Sbjct: 1079 GESSELQEQMVEQQQRAEELR-----------AQLGRKEEELQAALARAEDEGGARAQLL 1127

Query: 526  QQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK---QEATRQ 579
            +  +E QA LA+    L+ +  A      Q   L   L+    +L++  +    Q+  R 
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187

Query: 580  DHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
               Q++    +  E   R  +AA+++   L +     L  L +QL+ A   + + + +  
Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQE---LRQRHGQALGELAEQLEQARRGKGAWEKTRL 1244

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
              + E +EL  ++  LQ    TARQE  + + +   LELQL+  Q +A + ER   E   
Sbjct: 1245 ALEAEVSELRAELSSLQ----TARQEGEQRRRR---LELQLQEVQGRAGDGERARAE--- 1294

Query: 700  LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
              E+LQ  +  L+   G+L E + +              L  E  S   Q    ++ L+E
Sbjct: 1295 AAEKLQRAQAELENVSGALNEAESKTI-----------RLSKELSSTEAQLHDAQELLQE 1343

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
            E   +  L +R++    A +AE   LR +L E  AA+  A  E +    +++ WR R   
Sbjct: 1344 ETRAKLALGSRVR----AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR--- 1396

Query: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879
             Q+EEA      +E       E E   Q L E  E V  +E        R Q EL +   
Sbjct: 1397 -QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR----RLQQELDDATM 1451

Query: 880  NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
            +L +  Q V              STL++K     + +A  +  V +A E++E A  E  +
Sbjct: 1452 DLEQQRQLV--------------STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1497

Query: 940  EPARAGDRQPEWLEEQQGRQFCSTQ-----AALQAMEREAEQMGNELERLRAALMESQGQ 994
              ARA        EEQ+ R+    Q     A L+A+    + +G  +  L  A   ++  
Sbjct: 1498 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1557

Query: 995  QQEERGQQEREVARLTQERGRAQ-ADLALEKAARA-----ELEMRLQNALNEQRVEFATL 1048
              + R Q    V  L  E   A+ A L LE   +A     E +++ ++   E+R      
Sbjct: 1558 ANDLRAQ----VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER------ 1607

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIK----ELEELR-----------QTVKQLKEQ 1093
            +  LA  L + E +  E  K R L  A  K    ELEEL+           + VKQL++ 
Sbjct: 1608 RRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKM 1667

Query: 1094 LAKKE---KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC-----------QKQ 1139
             A+ +   +E      ++ E   +   +  +L+ L AEV +L+++            Q +
Sbjct: 1668 QAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1727

Query: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
             E AD +       +A+  E    LE   GQLEE+ +E   +   L    R+L      +
Sbjct: 1728 DEMADEVANG-NLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1786

Query: 1200 QDHSKAEDEWKAQVARGRQEAERK-NSLISSLEEE-----------VSILNRQVLEKEGE 1247
                 AE  + A+   GRQ+ ER+   L   L EE           ++ L  ++ + E +
Sbjct: 1787 TTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1846

Query: 1248 SKELKRLVMAESEKSQKLEERLR--LLQAETASNSA--------RAAERSSALREEVQSL 1297
             ++  R  +   +  ++ E+RL+  +LQ E     A        +   R   L+ +++  
Sbjct: 1847 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEA 1906

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQEL 1329
             EEA + +     L++EL    E AE + +E+
Sbjct: 1907 EEEASRAQAGRRRLQRELEDVTESAESMNREV 1938



 Score =  191 bits (484), Expect = 8e-48
 Identities = 260/1074 (24%), Positives = 471/1074 (43%), Gaps = 134/1074 (12%)

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
            +V ++ + LQ + Q L++        ++E ++++A  + E Q  +++L+ E   L EQ +
Sbjct: 863  QVTRQDEVLQARAQELQK--------VQELQQQSAREVGELQGRVAQLEEERARLAEQLR 914

Query: 752  RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
             E +   E    R  L AR Q+L E   +E E    E  E      T +   +Q ++E+ 
Sbjct: 915  AEAELCAEAEETRGRLAARKQEL-ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 973

Query: 812  AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871
            A  E  E ++Q+        Q + +T + + +K  ++L   +++ + +    +L     +
Sbjct: 974  AHLEAEEGARQK-------LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLL----E 1022

Query: 872  NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931
            + LAE  +  A   ++V+       K    ++ +++++    K    LE L R+   +  
Sbjct: 1023 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1082

Query: 932  TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLR---AAL 988
                ++V++  RA     E L  Q GR+    QAAL   E E       L+ LR   AAL
Sbjct: 1083 ELQEQMVEQQQRA-----EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1137

Query: 989  MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
             E+Q   + ER      VAR   E+ R      LE A R ELE  L +   +Q +     
Sbjct: 1138 AEAQEDLESER------VARTKAEKQRRDLGEELE-ALRGELEDTLDSTNAQQELRSKRE 1190

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
            QE     +TE +   +E  ++   EAA    ++ELRQ   Q   +LA++ ++   G GA 
Sbjct: 1191 QE-----VTELKKTLEEETRIH--EAA----VQELRQRHGQALGELAEQLEQARRGKGAW 1239

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE--------AERASRAER 1160
             +     E    ++  LRAE+S L+   Q+ +++   LE  L+         ERA RAE 
Sbjct: 1240 EKTRLALEA---EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA-RAEA 1295

Query: 1161 DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA-EDEWKAQVARGRQE 1219
               L+  Q +LE  +  L  ++S      +EL++   ++ D  +  ++E +A++A G   
Sbjct: 1296 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG--- 1352

Query: 1220 AERKNSLISSLEEEVSILNRQVLE----KEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275
                 S + ++E E + L  Q+ E    +E   +EL+      SE  ++ EE    L+A 
Sbjct: 1353 -----SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG 1407

Query: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL---TSQAERAEELGQELKAW 1332
              +   RAA  + AL + +    E  ++       L+QEL   T   E+  +L   L+  
Sbjct: 1408 EEARR-RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKK 1466

Query: 1333 QEKFFQ-----KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQ 1387
            Q KF Q     K   L  ++    +          A  L + L+ EQ A     REELE+
Sbjct: 1467 QRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA-----REELER 1521

Query: 1388 SKQAAGGLRAELLRAQRELGELI-PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGL 1446
              +A       LL ++ ++G+ +  L +     E+ A  LRA+     ++L+  + A   
Sbjct: 1522 QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR 1581

Query: 1447 LAEENRGLG---ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR 1503
            L    + L    ER   GR       D+A E+  ++LA      + R AEV+R+ +   R
Sbjct: 1582 LEVTVQALKTQHERDLQGR-------DEAGEERRRQLAK-----QLRDAEVERDEERKQR 1629

Query: 1504 ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQ 1563
             L V               R++ + E ++L AQ+      + E  KQ+ ++  ++ +  +
Sbjct: 1630 TLAVAA-------------RKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1676

Query: 1564 ASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA---AEHYKLQMEKAKTH 1620
              +  +   + + +Q  ES++  + L+A++  LQ +L+  ++A   A+  + +M     +
Sbjct: 1677 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1736

Query: 1621 YDAKK---------------QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLK 1665
             +  K               Q  +EL+E+  + E L    ++L  + E L  EL      
Sbjct: 1737 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1796

Query: 1666 TKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
            + +AE   + L  Q++ L  ++   D   R   K  +A  AL+S+  QA+ QL+
Sbjct: 1797 SAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIA--ALESKLAQAEEQLE 1848



 Score =  156 bits (394), Expect = 2e-37
 Identities = 225/952 (23%), Positives = 404/952 (42%), Gaps = 134/952 (14%)

Query: 865  LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
            LQ++RQ   L       A+ LQ+VQE +   Q+ A ++  LQ ++A   +E ARL   +R
Sbjct: 862  LQVTRQDEVLQAR----AQELQKVQELQ---QQSAREVGELQGRVAQLEEERARLAEQLR 914

Query: 925  K----AGEQQETASR--------ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
                   E +ET  R        ELV     A   + E    Q   +    Q  +Q +E 
Sbjct: 915  AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEA 974

Query: 973  --EAEQMGNELERLRAALMESQGQQ-QEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
              EAE+   +  +L     E++ ++ +E+    E + ++L++ER   +  LA   +  AE
Sbjct: 975  HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1034

Query: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL----RQ 1085
             E ++++ LN+ R+++      +   L ++E   QEL KL+     +  EL+E     +Q
Sbjct: 1035 EEEKVKS-LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1093

Query: 1086 TVKQLKEQLAKKEKE-HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
              ++L+ QL +KE+E  A+ + A+ E   R +     L++LR      E Q    + Q D
Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQ----LLKSLR------EAQAALAEAQED 1143

Query: 1145 SLERSLEAERASRAERD--SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
                 +   +A +  RD    LE L+G+LE+        Q   +  ++E+   +  +   
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL--- 1200

Query: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV-------LEKEGESKELKRLV 1255
               E+E +   A  ++  +R    +  L E++    R         L  E E  EL+  +
Sbjct: 1201 ---EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1257

Query: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL 1315
             +     Q+ E+R R L+ +      RA +   A  E  + L    ++ +   EN+   L
Sbjct: 1258 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL----QRAQAELENVSGAL 1313

Query: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQA 1375
                 +   L +EL + +    Q   A   LQ E  +  AL S +       + ++AE A
Sbjct: 1314 NEAESKTIRLSKELSSTEA---QLHDAQELLQEETRAKLALGSRV-------RAMEAEAA 1363

Query: 1376 AAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAE 1435
                  RE+LE+   A      EL  AQ +L E    +++ A      ++ R   A  AE
Sbjct: 1364 GL----REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1419

Query: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA----------------REKYVQE 1479
             L+        LAE+   + +R   GR+ L+ ELD A                +++   +
Sbjct: 1420 ALTQR------LAEKTETV-DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQ 1472

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            L A    A  R  E +  A++  RE E        A  +  E R+  + + + L A++E 
Sbjct: 1473 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1532

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
            L   + +  K V EL +    ++QA+   + ++  ++ +   ++    RL+  +  L+ Q
Sbjct: 1533 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1592

Query: 1600 ----LSQKEQAAEHYKLQMEK----AKTHYD-----------AKKQQNQEL--------- 1631
                L  +++A E  + Q+ K    A+   D           A+K+   EL         
Sbjct: 1593 HERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1652

Query: 1632 -----QEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686
                 +E ++ L ++Q + KEL  E E      ++   + +E+E+  + L A+V  L+ +
Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1712

Query: 1687 VAHAD------QQLRDLGKFQVATDAL-KSREPQAKPQLDLSIDSLDLSCEE 1731
            +A +D      QQ RD    +VA   L K+   + K QL+  +  L+   EE
Sbjct: 1713 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1764



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 61/283 (21%), Positives = 130/283 (45%), Gaps = 40/283 (14%)

Query: 1468 ELDQAREKYVQEL-----AAVRADAETRLAEVQREAQSTARELEVMTAKYEG-------- 1514
            +L++ R+  V ++     AA R     R  + +++ QS  R ++   A Y          
Sbjct: 794  QLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWR 853

Query: 1515 --AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
               KVK L +  R  E  Q    ++++++  Q++  ++V EL  ++A  ++      ++L
Sbjct: 854  LFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQL 913

Query: 1573 KAVQAQGGESQQEAQRLQAQ-------LNELQAQLSQKEQAA-----EHYKLQ--MEKAK 1618
            +A      E+++   RL A+       ++EL+A++ ++E+ +     E  +LQ  +++ +
Sbjct: 914  RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 973

Query: 1619 THYDAKKQQNQELQ-------EQLRSLEQ----LQKENKELRAEAERLGHELQQAGLKTK 1667
             H +A++   Q+LQ        +++  E+    L+ +N +L  E + L   L +   +  
Sbjct: 974  AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAA 1033

Query: 1668 EAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSR 1710
            E E+  + L       EA +A  + +LR   K +   + LK R
Sbjct: 1034 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRR 1076



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 75/349 (21%), Positives = 152/349 (43%), Gaps = 43/349 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
            L+  Q QM+ L +++ + R++R+E+  +  E+ K L   +A++  +Q          E+ 
Sbjct: 1664 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ----------EEL 1713

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
            AAS    ++ ++  D++E      +  L +   L+ EK Q++ ++ QL EE       L 
Sbjct: 1714 AASDRARRQAQQ--DRDEMADEVANGNLSKAAILE-EKRQLEGRLGQLEEE-------LE 1763

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA-ALQDKKCLEEKNEILQGKL 387
            E  S+ + L D   +L  +    T E        E+  SA A   ++ LE + + L+G+L
Sbjct: 1764 EEQSNSELLNDRYRKLLLQVESLTTE-----LSAERSFSAKAESGRQQLERQIQELRGRL 1818

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
             +             ++ G      + +  L+ + A  A    + + R  +L  +  ++ 
Sbjct: 1819 GE-------------EDAGARARHKMTIAALESKLAQ-AEEQLEQETRERILSGKLVRRA 1864

Query: 448  AKLLAERG-HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
             K L E     EEE++    L   L+     + Q K +LE+A +   +R  A    L  E
Sbjct: 1865 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE-EASRAQAGRRRLQRE 1923

Query: 507  LTTLNATIQQQDQELAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVE 554
            L  +  + +  ++E+  L+ + +        +T++Q  +  +G+    E
Sbjct: 1924 LEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1972



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 12/111 (10%)

Query: 1626 QQNQELQEQ-LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
            Q+ QELQ+Q  R + +LQ    +L  E  RL  +L+       EAE+T   L A+ + LE
Sbjct: 879  QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELE 938

Query: 1685 AQVAHADQQLRDLGKFQVATDALKSREPQA-KPQLDLSIDSLD--LSCEEG 1732
              V+  +         +V  +   SR+ Q  K +L   I  L+  L  EEG
Sbjct: 939  LVVSELEA--------RVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 981



 Score = 32.3 bits (72), Expect = 5.1
 Identities = 27/128 (21%), Positives = 59/128 (46%), Gaps = 6/128 (4%)

Query: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
            Q  Q++Q+A   ++       +   +  Q   L  +++ L Q+ ++++ L+A A+    E
Sbjct: 824  QKRQQQQSA--LRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQ----E 877

Query: 1659 LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQL 1718
            LQ+     +++ +    L  +V  LE + A   +QLR   +     +  + R    K +L
Sbjct: 878  LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 937

Query: 1719 DLSIDSLD 1726
            +L +  L+
Sbjct: 938  ELVVSELE 945


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score =  210 bits (535), Expect = 1e-53
 Identities = 304/1255 (24%), Positives = 521/1255 (41%), Gaps = 187/1255 (14%)

Query: 379  KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
            ++E+LQ +  +L++ + +LQ    +E GE+ G V QLE   +E A LA    QL+A  E+
Sbjct: 908  QDEVLQARAQELQK-VQELQQQSAREVGELQGRVAQLE---EERARLAE---QLRAEAEL 960

Query: 439  LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498
                     A+    RG     KQ+L  ++++L++ +      +EE  +  Q    RL  
Sbjct: 961  C--------AEAEETRGRLAARKQELELVVSELEARVGE----EEECSRQMQTEKKRLQQ 1008

Query: 499  QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS 558
             +  L + L       Q+   E    K   + K  +  + L   E  +  L  + + L  
Sbjct: 1009 HIQELEAHLEAEEGARQKLQLE----KVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED 1064

Query: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
             L +   Q  E  EK ++  +   +  AT A+  E  LR+ +   ++LE L++    +  
Sbjct: 1065 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD-MEDRLRKEEKGRQELEKLKRRLDGESS 1123

Query: 619  ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ----------HE 668
             LQ+Q+    +          +A+  +A+L RK EELQA +  A  E            E
Sbjct: 1124 ELQEQMVEQQQ----------RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLRE 1173

Query: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
            AQA +A        E Q+  E ERVA+ K   ++Q + L E L+  +G LE+      D+
Sbjct: 1174 AQAALA--------EAQEDLESERVARTK--AEKQRRDLGEELEALRGELED----TLDS 1219

Query: 729  LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
               QQ        E RS  EQ   E K+  EE       E R+      H+A  + LR+ 
Sbjct: 1220 TNAQQ--------ELRSKREQEVTELKKTLEE-------ETRI------HEAAVQELRQR 1258

Query: 789  LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
              +A+        + EQ  +   AW +     + E ++  A     L T ++E E+ R+ 
Sbjct: 1259 HGQALG---ELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL-SSLQTARQEGEQRRRR 1314

Query: 849  LQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEK 908
            L              ELQ+   Q    +     A A +++Q  +   + ++  L+  + K
Sbjct: 1315 L--------------ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1360

Query: 909  MAATSKEVARLETLVRKAGE--QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA 966
                SKE++  E  +  A E  Q+ET ++  +    RA + +   L EQ           
Sbjct: 1361 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ----------- 1409

Query: 967  LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE--REVARLTQERGRAQADLALEK 1024
            L+      E+ G EL+  +A L E + +Q+EE G  E   E  R       A      EK
Sbjct: 1410 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1469

Query: 1025 AARAEL----EMRLQNALNEQRVEFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKE 1079
                +       RLQ  L++  ++    Q  L   L +K+ K DQ LA+ +   AA ++ 
Sbjct: 1470 TETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEEK---AAVLRA 1525

Query: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
            +EE  +   + +E    +E    S + A  E     E    +  ALRAE+  L       
Sbjct: 1526 VEERERAEAEGRE----REARALSLTRALEEEQEAREELERQNRALRAELEAL------- 1574

Query: 1140 QEQADSLERSL-EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTK 1198
                D + +S+ E ERA R   + A   L+ Q+ E   EL  ++ A    +  + A +T+
Sbjct: 1575 LSSKDDVGKSVHELERACRV-AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1633

Query: 1199 ----VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254
                +Q   +A +E + Q+A+  ++AE +       +  +++  R+ L  EGE +ELK  
Sbjct: 1634 HERDLQGRDEAGEERRRQLAKQLRDAEVERD-EERKQRTLAVAARKKL--EGELEELKAQ 1690

Query: 1255 VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK--QRVASENLR 1312
            + +  +  ++  ++LR +QA+      R  E +   REE+ S   E+EK  + + +E LR
Sbjct: 1691 MASAGQGKEEAVKQLRKMQAQ-MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1749

Query: 1313 -QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ 1371
             QE  + ++RA    Q+          +++    +   + S  A++ E        +QL+
Sbjct: 1750 LQEELAASDRARRQAQQ---------DRDEMADEVANGNLSKAAILEEK-------RQLE 1793

Query: 1372 AEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKA 1431
                  E+   EE   S+      R  LL+ +    EL   R   A+ E   QQL  +  
Sbjct: 1794 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ-- 1851

Query: 1432 SYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL------AAVRA 1485
                    +++  G L EE+ G   R  +    LE +L QA E+  QE         +  
Sbjct: 1852 --------IQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1903

Query: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL----------EERQRFQEERQKLTA 1535
             AE RL EV  + +   R  + +  + E   ++V           EE  R Q  R++L  
Sbjct: 1904 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963

Query: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
            ++E +        ++V  L  +L         +  +      +G  S +EA+  Q
Sbjct: 1964 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018



 Score =  200 bits (509), Expect = 1e-50
 Identities = 307/1413 (21%), Positives = 599/1413 (42%), Gaps = 200/1413 (14%)

Query: 392  EHLSQLQDNPP--QEKGEVLGDVLQL--ETLKQEAATLAANNTQ-LQARVEMLETERGQQ 446
            E +S L D PP  + +  +   V QL  E+L +  ATL+  N   ++  V   E   G+ 
Sbjct: 689  EQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKL 748

Query: 447  EAKLLAE--------------------RGHFEEEKQQLSSLITD-LQSSISNLSQAKEEL 485
            E +L+ +                    R  F+E +Q+   L  + +     +  QA E++
Sbjct: 749  EPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKM 808

Query: 486  EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL--KQQAKEKQAQLAQTLQQQE 543
             QA +          + +      L    +++D ++  +    QA  +     +  Q+++
Sbjct: 809  IQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQ 868

Query: 544  QASQGLRHQVEQLSSSLKQKEQQ----LKEVAEKQEATRQDH-----AQQLATAAEEREA 594
            Q    LR      ++ LK +  Q      +V    + TRQD      AQ+L    E ++ 
Sbjct: 869  QQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQ 928

Query: 595  SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK---AELSRK 651
            S RE      ++  LE+E+A   E L+ + ++  EA ++      + Q  +   +EL  +
Sbjct: 929  SAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR 988

Query: 652  VEELQACVETARQEQHEAQAQVAELELQLRSEQ--------QKATEKERVAQEKDQ---L 700
            V E + C    + E+   Q  + ELE  L +E+        +K T + ++ + ++    L
Sbjct: 989  VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1048

Query: 701  QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
            ++Q   L +  K+ +  L E   +AA+  EE+ + +++L+ +  + +   +     L +E
Sbjct: 1049 EDQNSKLSKERKLLEDRLAEFSSQAAEE-EEKVKSLNKLRLKYEATIADME---DRLRKE 1104

Query: 761  RAGRKGLEARLQQL-GEAHQAETEVL-RRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
              GR+ LE   ++L GE+ + + +++ +++ AE + AQ   + E      E+ A   R E
Sbjct: 1105 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE------ELQAALARAE 1158

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            D     A        QL+    E + A  E QE  E      + +E Q      EL  L 
Sbjct: 1159 DEGGARA--------QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALR 1210

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L   L              D  +  QE  +   +EV  L+  + +     E A +EL 
Sbjct: 1211 GELEDTL--------------DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1256

Query: 939  KEPARAGDRQPEWLEE-QQGR-QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
            +   +A     E LE+ ++G+  +  T+ AL+A          E+  LRA L   Q  +Q
Sbjct: 1257 QRHGQALGELAEQLEQARRGKGAWEKTRLALEA----------EVSELRAELSSLQTARQ 1306

Query: 997  EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
            E   ++ R   +L + +GRA       + ARAE   +LQ A  E         E ++ AL
Sbjct: 1307 EGEQRRRRLELQLQEVQGRAGDG----ERARAEAAEKLQRAQAE--------LENVSGAL 1354

Query: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK----EKEHASGSGAQSEAA 1112
             E E K   L+K      AQ+ + +EL Q   + K  L  +    E E A       E A
Sbjct: 1355 NEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEA 1414

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE------- 1165
               E  G +L+  +A++S+     ++Q+E+A +LE   EA R +  E ++  +       
Sbjct: 1415 AARERAGRELQTAQAQLSEWR---RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE 1471

Query: 1166 ----------TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHS----KAEDEWKA 1211
                       LQ +L++   +L   +  +++ +++   F   + +      +A +E + 
Sbjct: 1472 TVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERER 1531

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGES--KELKRLVMAESEKSQKLEERL 1269
              A GR+   R  SL  +LEEE     R+ LE++  +   EL+ L+ ++ +  + + E  
Sbjct: 1532 AEAEGREREARALSLTRALEEEQEA--REELERQNRALRAELEALLSSKDDVGKSVHELE 1589

Query: 1270 RLLQ-AETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
            R  + AE A+N  RA  + + L +E+ +  +   +  V  + L+ +     +  +E G+E
Sbjct: 1590 RACRVAEQAANDLRA--QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE 1647

Query: 1329 -----LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
                  K  ++   ++++      L   + + L  EL       ++L+A+ A+A +   E
Sbjct: 1648 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL-------EELKAQMASAGQGKEE 1700

Query: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ----LRAEKASYAEQLSM 1439
             ++Q ++    ++A++    RE+ E    R+++  Q R +++    L AE     E+L+ 
Sbjct: 1701 AVKQLRK----MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1756

Query: 1440 LKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499
              +A     ++   + +    G       L++ R+             E RL +++ E +
Sbjct: 1757 SDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQ------------LEGRLGQLEEELE 1804

Query: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
                  E++  +Y    ++V         ER   +A+ E     +++  +Q++EL  +L 
Sbjct: 1805 EEQSNSELLNDRYRKLLLQVESLTTELSAER-SFSAKAES---GRQQLERQIQELRGRLG 1860

Query: 1560 DSDQASKVQQQ------KLKAVQAQGGESQQEAQRL---------QAQLNELQAQLSQKE 1604
            + D  ++ + +      + K  QA+    Q+  +R+         + +L E+  Q+ ++ 
Sbjct: 1861 EEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1920

Query: 1605 QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKELRAEAERLGHELQ 1660
            + A+  + Q+EK        K+Q +E +E+    +    +LQ+E +++   AE +  E+ 
Sbjct: 1921 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1980

Query: 1661 QAGLKTKEAEQTCRHLTA-QVRSLEAQVAHADQ 1692
                + +    T    T  QV  LE  VA  ++
Sbjct: 1981 TLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 2013



 Score =  198 bits (504), Expect = 4e-50
 Identities = 284/1172 (24%), Positives = 485/1172 (41%), Gaps = 176/1172 (15%)

Query: 242  KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE----ELRDKNESLTMRLHETLK 297
            K L +   Q  ++Q R   L  + E Q  S  E  EL+    +L ++   L  +L    +
Sbjct: 900  KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 959

Query: 298  QCQD-------LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK 350
             C +       L   K +++  +++L    G+     R+  +  ++LQ  + EL E H +
Sbjct: 960  LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQEL-EAHLE 1018

Query: 351  ATQEWLEKQAQLEKELSAAL-----QDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405
            A +E   ++ QLEK  + A      +D   LE++N  L  +   LE+ L++      +E+
Sbjct: 1019 A-EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1077

Query: 406  GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS 465
             +V    L    LK E AT+A    +L+      + E+G+QE          E+ K++L 
Sbjct: 1078 EKVKS--LNKLRLKYE-ATIADMEDRLR------KEEKGRQE---------LEKLKRRLD 1119

Query: 466  SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525
               ++LQ  +    Q  EEL            AQ+     EL    A  + +    A L 
Sbjct: 1120 GESSELQEQMVEQQQRAEELR-----------AQLGRKEEELQAALARAEDEGGARAQLL 1168

Query: 526  QQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK---QEATRQ 579
            +  +E QA LA+    L+ +  A      Q   L   L+    +L++  +    Q+  R 
Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1228

Query: 580  DHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
               Q++    +  E   R  +AA+++   L +     L  L +QL+ A   + + + +  
Sbjct: 1229 KREQEVTELKKTLEEETRIHEAAVQE---LRQRHGQALGELAEQLEQARRGKGAWEKTRL 1285

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
              + E +EL  ++  LQ    TARQE  + + +   LELQL+  Q +A + ER   E   
Sbjct: 1286 ALEAEVSELRAELSSLQ----TARQEGEQRRRR---LELQLQEVQGRAGDGERARAE--- 1335

Query: 700  LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
              E+LQ  +  L+   G+L E + +              L  E  S   Q    ++ L+E
Sbjct: 1336 AAEKLQRAQAELENVSGALNEAESKTI-----------RLSKELSSTEAQLHDAQELLQE 1384

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
            E   +  L +R++    A +AE   LR +L E  AA+  A  E +    +++ WR R   
Sbjct: 1385 ETRAKLALGSRVR----AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR--- 1437

Query: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879
             Q+EEA      +E       E E   Q L E  E V  +E        R Q EL +   
Sbjct: 1438 -QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR----RLQQELDDATM 1492

Query: 880  NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
            +L +  Q V              STL++K     + +A  +  V +A E++E A  E  +
Sbjct: 1493 DLEQQRQLV--------------STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1538

Query: 940  EPARAGDRQPEWLEEQQGRQFCSTQ-----AALQAMEREAEQMGNELERLRAALMESQGQ 994
              ARA        EEQ+ R+    Q     A L+A+    + +G  +  L  A   ++  
Sbjct: 1539 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1598

Query: 995  QQEERGQQEREVARLTQERGRAQ-ADLALEKAARA-----ELEMRLQNALNEQRVEFATL 1048
              + R Q    V  L  E   A+ A L LE   +A     E +++ ++   E+R      
Sbjct: 1599 ANDLRAQ----VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER------ 1648

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIK----ELEELR-----------QTVKQLKEQ 1093
            +  LA  L + E +  E  K R L  A  K    ELEEL+           + VKQL++ 
Sbjct: 1649 RRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKM 1708

Query: 1094 LAKKE---KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC-----------QKQ 1139
             A+ +   +E      ++ E   +   +  +L+ L AEV +L+++            Q +
Sbjct: 1709 QAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1768

Query: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
             E AD +       +A+  E    LE   GQLEE+ +E   +   L    R+L      +
Sbjct: 1769 DEMADEVANG-NLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1827

Query: 1200 QDHSKAEDEWKAQVARGRQEAERK-NSLISSLEEE-----------VSILNRQVLEKEGE 1247
                 AE  + A+   GRQ+ ER+   L   L EE           ++ L  ++ + E +
Sbjct: 1828 TTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1887

Query: 1248 SKELKRLVMAESEKSQKLEERLR--LLQAETASNSA--------RAAERSSALREEVQSL 1297
             ++  R  +   +  ++ E+RL+  +LQ E     A        +   R   L+ +++  
Sbjct: 1888 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEA 1947

Query: 1298 REEAEKQRVASENLRQELTSQAERAEELGQEL 1329
             EEA + +     L++EL    E AE + +E+
Sbjct: 1948 EEEASRAQAGRRRLQRELEDVTESAESMNREV 1979



 Score =  191 bits (484), Expect = 8e-48
 Identities = 260/1074 (24%), Positives = 471/1074 (43%), Gaps = 134/1074 (12%)

Query: 692  RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
            +V ++ + LQ + Q L++        ++E ++++A  + E Q  +++L+ E   L EQ +
Sbjct: 904  QVTRQDEVLQARAQELQK--------VQELQQQSAREVGELQGRVAQLEEERARLAEQLR 955

Query: 752  RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
             E +   E    R  L AR Q+L E   +E E    E  E      T +   +Q ++E+ 
Sbjct: 956  AEAELCAEAEETRGRLAARKQEL-ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 1014

Query: 812  AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871
            A  E  E ++Q+        Q + +T + + +K  ++L   +++ + +    +L     +
Sbjct: 1015 AHLEAEEGARQK-------LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLL----E 1063

Query: 872  NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931
            + LAE  +  A   ++V+       K    ++ +++++    K    LE L R+   +  
Sbjct: 1064 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1123

Query: 932  TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLR---AAL 988
                ++V++  RA     E L  Q GR+    QAAL   E E       L+ LR   AAL
Sbjct: 1124 ELQEQMVEQQQRA-----EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1178

Query: 989  MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
             E+Q   + ER      VAR   E+ R      LE A R ELE  L +   +Q +     
Sbjct: 1179 AEAQEDLESER------VARTKAEKQRRDLGEELE-ALRGELEDTLDSTNAQQELRSKRE 1231

Query: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
            QE     +TE +   +E  ++   EAA    ++ELRQ   Q   +LA++ ++   G GA 
Sbjct: 1232 QE-----VTELKKTLEEETRIH--EAA----VQELRQRHGQALGELAEQLEQARRGKGAW 1280

Query: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE--------AERASRAER 1160
             +     E    ++  LRAE+S L+   Q+ +++   LE  L+         ERA RAE 
Sbjct: 1281 EKTRLALEA---EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA-RAEA 1336

Query: 1161 DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA-EDEWKAQVARGRQE 1219
               L+  Q +LE  +  L  ++S      +EL++   ++ D  +  ++E +A++A G   
Sbjct: 1337 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG--- 1393

Query: 1220 AERKNSLISSLEEEVSILNRQVLE----KEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275
                 S + ++E E + L  Q+ E    +E   +EL+      SE  ++ EE    L+A 
Sbjct: 1394 -----SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG 1448

Query: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL---TSQAERAEELGQELKAW 1332
              +   RAA  + AL + +    E  ++       L+QEL   T   E+  +L   L+  
Sbjct: 1449 EEARR-RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKK 1507

Query: 1333 QEKFFQ-----KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQ 1387
            Q KF Q     K   L  ++    +          A  L + L+ EQ A     REELE+
Sbjct: 1508 QRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA-----REELER 1562

Query: 1388 SKQAAGGLRAELLRAQRELGELI-PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGL 1446
              +A       LL ++ ++G+ +  L +     E+ A  LRA+     ++L+  + A   
Sbjct: 1563 QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR 1622

Query: 1447 LAEENRGLG---ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR 1503
            L    + L    ER   GR       D+A E+  ++LA      + R AEV+R+ +   R
Sbjct: 1623 LEVTVQALKTQHERDLQGR-------DEAGEERRRQLAK-----QLRDAEVERDEERKQR 1670

Query: 1504 ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQ 1563
             L V               R++ + E ++L AQ+      + E  KQ+ ++  ++ +  +
Sbjct: 1671 TLAVAA-------------RKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1717

Query: 1564 ASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA---AEHYKLQMEKAKTH 1620
              +  +   + + +Q  ES++  + L+A++  LQ +L+  ++A   A+  + +M     +
Sbjct: 1718 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1777

Query: 1621 YDAKK---------------QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLK 1665
             +  K               Q  +EL+E+  + E L    ++L  + E L  EL      
Sbjct: 1778 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1837

Query: 1666 TKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
            + +AE   + L  Q++ L  ++   D   R   K  +A  AL+S+  QA+ QL+
Sbjct: 1838 SAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIA--ALESKLAQAEEQLE 1889



 Score =  156 bits (394), Expect = 2e-37
 Identities = 225/952 (23%), Positives = 404/952 (42%), Gaps = 134/952 (14%)

Query: 865  LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
            LQ++RQ   L       A+ LQ+VQE +   Q+ A ++  LQ ++A   +E ARL   +R
Sbjct: 903  LQVTRQDEVLQAR----AQELQKVQELQ---QQSAREVGELQGRVAQLEEERARLAEQLR 955

Query: 925  K----AGEQQETASR--------ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
                   E +ET  R        ELV     A   + E    Q   +    Q  +Q +E 
Sbjct: 956  AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEA 1015

Query: 973  --EAEQMGNELERLRAALMESQGQQ-QEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
              EAE+   +  +L     E++ ++ +E+    E + ++L++ER   +  LA   +  AE
Sbjct: 1016 HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1075

Query: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL----RQ 1085
             E ++++ LN+ R+++      +   L ++E   QEL KL+     +  EL+E     +Q
Sbjct: 1076 EEEKVKS-LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1134

Query: 1086 TVKQLKEQLAKKEKE-HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
              ++L+ QL +KE+E  A+ + A+ E   R +     L++LR      E Q    + Q D
Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQ----LLKSLR------EAQAALAEAQED 1184

Query: 1145 SLERSLEAERASRAERD--SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
                 +   +A +  RD    LE L+G+LE+        Q   +  ++E+   +  +   
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL--- 1241

Query: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV-------LEKEGESKELKRLV 1255
               E+E +   A  ++  +R    +  L E++    R         L  E E  EL+  +
Sbjct: 1242 ---EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1298

Query: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL 1315
             +     Q+ E+R R L+ +      RA +   A  E  + L    ++ +   EN+   L
Sbjct: 1299 SSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL----QRAQAELENVSGAL 1354

Query: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQA 1375
                 +   L +EL + +    Q   A   LQ E  +  AL S +       + ++AE A
Sbjct: 1355 NEAESKTIRLSKELSSTEA---QLHDAQELLQEETRAKLALGSRV-------RAMEAEAA 1404

Query: 1376 AAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAE 1435
                  RE+LE+   A      EL  AQ +L E    +++ A      ++ R   A  AE
Sbjct: 1405 GL----REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1460

Query: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA----------------REKYVQE 1479
             L+        LAE+   + +R   GR+ L+ ELD A                +++   +
Sbjct: 1461 ALTQR------LAEKTETV-DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQ 1513

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            L A    A  R  E +  A++  RE E        A  +  E R+  + + + L A++E 
Sbjct: 1514 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1573

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
            L   + +  K V EL +    ++QA+   + ++  ++ +   ++    RL+  +  L+ Q
Sbjct: 1574 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQ 1633

Query: 1600 ----LSQKEQAAEHYKLQMEK----AKTHYD-----------AKKQQNQEL--------- 1631
                L  +++A E  + Q+ K    A+   D           A+K+   EL         
Sbjct: 1634 HERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1693

Query: 1632 -----QEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686
                 +E ++ L ++Q + KEL  E E      ++   + +E+E+  + L A+V  L+ +
Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE 1753

Query: 1687 VAHAD------QQLRDLGKFQVATDAL-KSREPQAKPQLDLSIDSLDLSCEE 1731
            +A +D      QQ RD    +VA   L K+   + K QL+  +  L+   EE
Sbjct: 1754 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1805



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 61/283 (21%), Positives = 130/283 (45%), Gaps = 40/283 (14%)

Query: 1468 ELDQAREKYVQEL-----AAVRADAETRLAEVQREAQSTARELEVMTAKYEG-------- 1514
            +L++ R+  V ++     AA R     R  + +++ QS  R ++   A Y          
Sbjct: 835  QLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWR 894

Query: 1515 --AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
               KVK L +  R  E  Q    ++++++  Q++  ++V EL  ++A  ++      ++L
Sbjct: 895  LFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQL 954

Query: 1573 KAVQAQGGESQQEAQRLQAQ-------LNELQAQLSQKEQAA-----EHYKLQ--MEKAK 1618
            +A      E+++   RL A+       ++EL+A++ ++E+ +     E  +LQ  +++ +
Sbjct: 955  RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 1014

Query: 1619 THYDAKKQQNQELQ-------EQLRSLEQ----LQKENKELRAEAERLGHELQQAGLKTK 1667
             H +A++   Q+LQ        +++  E+    L+ +N +L  E + L   L +   +  
Sbjct: 1015 AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAA 1074

Query: 1668 EAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSR 1710
            E E+  + L       EA +A  + +LR   K +   + LK R
Sbjct: 1075 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRR 1117



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 75/349 (21%), Positives = 152/349 (43%), Gaps = 43/349 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
            L+  Q QM+ L +++ + R++R+E+  +  E+ K L   +A++  +Q          E+ 
Sbjct: 1705 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ----------EEL 1754

Query: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
            AAS    ++ ++  D++E      +  L +   L+ EK Q++ ++ QL EE       L 
Sbjct: 1755 AASDRARRQAQQ--DRDEMADEVANGNLSKAAILE-EKRQLEGRLGQLEEE-------LE 1804

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA-ALQDKKCLEEKNEILQGKL 387
            E  S+ + L D   +L  +    T E        E+  SA A   ++ LE + + L+G+L
Sbjct: 1805 EEQSNSELLNDRYRKLLLQVESLTTE-----LSAERSFSAKAESGRQQLERQIQELRGRL 1859

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
             +             ++ G      + +  L+ + A  A    + + R  +L  +  ++ 
Sbjct: 1860 GE-------------EDAGARARHKMTIAALESKLAQ-AEEQLEQETRERILSGKLVRRA 1905

Query: 448  AKLLAERG-HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
             K L E     EEE++    L   L+     + Q K +LE+A +   +R  A    L  E
Sbjct: 1906 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE-EASRAQAGRRRLQRE 1964

Query: 507  LTTLNATIQQQDQELAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVE 554
            L  +  + +  ++E+  L+ + +        +T++Q  +  +G+    E
Sbjct: 1965 LEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 2013



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 12/111 (10%)

Query: 1626 QQNQELQEQ-LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
            Q+ QELQ+Q  R + +LQ    +L  E  RL  +L+       EAE+T   L A+ + LE
Sbjct: 920  QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELE 979

Query: 1685 AQVAHADQQLRDLGKFQVATDALKSREPQA-KPQLDLSIDSLD--LSCEEG 1732
              V+  +         +V  +   SR+ Q  K +L   I  L+  L  EEG
Sbjct: 980  LVVSELEA--------RVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022



 Score = 32.3 bits (72), Expect = 5.1
 Identities = 27/128 (21%), Positives = 59/128 (46%), Gaps = 6/128 (4%)

Query: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
            Q  Q++Q+A   ++       +   +  Q   L  +++ L Q+ ++++ L+A A+    E
Sbjct: 865  QKRQQQQSA--LRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQ----E 918

Query: 1659 LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQL 1718
            LQ+     +++ +    L  +V  LE + A   +QLR   +     +  + R    K +L
Sbjct: 919  LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 978

Query: 1719 DLSIDSLD 1726
            +L +  L+
Sbjct: 979  ELVVSELE 986


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  210 bits (535), Expect = 1e-53
 Identities = 286/1401 (20%), Positives = 614/1401 (43%), Gaps = 165/1401 (11%)

Query: 273  LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
            L+  ++  LR + + L   L E     ++LK E  +      Q ++ +G ++    E  S
Sbjct: 80   LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139

Query: 333  HLQQLQDALNELTEEHSKATQEWLE-KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
              QQL++A  E    + K  ++  E K AQL  E++             E  + K+++L 
Sbjct: 140  LEQQLEEAQTE--NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197

Query: 392  EHLSQLQDNPPQEKGEVLGDVLQLETLK----QEAATLAANNTQLQARVEMLETERGQQE 447
            E L++        +  V+ D L+ E L+    ++ A L     Q+Q  ++ +  ER ++ 
Sbjct: 198  EELNK--------EATVIQD-LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248

Query: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA------RLTAQVA 501
             KL          K +   L +   SS + +SQ + EL +  Q          +L + V 
Sbjct: 249  EKL----------KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN 298

Query: 502  SLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ---LAQTLQQQEQASQGLRHQVEQLSS 558
             LT +  TL   + +++Q+   L+++  E+      +  TL Q++   Q L+ ++    +
Sbjct: 299  ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASET 358

Query: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
            SL +   +L   +EK EAT     Q+L     E E   +   A  KQL+   +EK     
Sbjct: 359  SLHRIHVEL---SEKGEAT-----QKLKEELSEVETKYQHLKAEFKQLQQQREEKE---- 406

Query: 619  ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC----VETARQEQHEAQAQVA 674
              Q  LQ+ +E  +   + + + +R+  E   +++E +      +    Q+  + Q +++
Sbjct: 407  --QHGLQLQSEI-NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463

Query: 675  ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
             LE QL+ +   +TE +    +  Q  ++ QAL++S        + +  +    + ++ +
Sbjct: 464  RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523

Query: 735  CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
             I  L+A    L+++ K     LE+ER   + L A++Q    A + ET VL     +   
Sbjct: 524  KIQNLEA----LLQKSKENISLLEKER---EDLYAKIQ----AGEGETAVLN----QLQE 568

Query: 795  AQHTAESECEQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQEQLMTLKEECEKARQ 847
              HT + +  QL +++    E ++ +Q       QE+  +    Q+++++L+    +   
Sbjct: 569  KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628

Query: 848  ELQEAKEKVAG----IESHSELQISRQQNELAE---LHANLARALQQVQEKEVRAQKLAD 900
            +L E+KEKV+     I++ +EL +S +  + A+   L  +L  A   +Q+K+    K+  
Sbjct: 629  QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688

Query: 901  DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960
             L  +  K+    +  ++LE+ +++  E+  +  ++  +   +    + + LE +     
Sbjct: 689  QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK----- 743

Query: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER-EVARLTQERGRAQAD 1019
             S + ALQ ++++  Q+  +LE LRA  +  Q + ++E     R ++ + ++     +  
Sbjct: 744  ASKEQALQDLQQQ-RQLNTDLE-LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801

Query: 1020 LALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE 1079
            L  ++  +  L+   +    E +++   L   +   +TE +    E   L   E + +K+
Sbjct: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM-TELSTVKD 860

Query: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
              +L +    LK   ++ EKE+  G  A  +     +    +L+       ++E   ++Q
Sbjct: 861  --KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV------QMENTLKEQ 912

Query: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
            +E   SLE+  EA    + E                         L S Q +L   +  +
Sbjct: 913  KELKKSLEKEKEASHQLKLE-------------------------LNSMQEQLIQAQNTL 947

Query: 1200 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAES 1259
            + + K E + +  +   +Q +E+K   I +L+ E                 LK  V+ ++
Sbjct: 948  KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE-----------------LKIAVLQKT 990

Query: 1260 EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA 1319
            E   KL+++L            +AA+  +A +E++  L+   EK +   + L+ +   + 
Sbjct: 991  ELENKLQQQL-----------TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039

Query: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
                   Q+LK+ +EK    ++ L + + +  +   L+ EL  AK   +Q  A++    +
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099

Query: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLR-QKVAEQERTAQQLRAEKASYAEQLS 1438
               + L+  ++       EL+  + +L E+  ++ ++  E  +  ++L++ K    ++++
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEIT 1159

Query: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA 1498
             LK A  LL ++   L  +A+  +  +E E    R + + +    + + E +   +++EA
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQE---KRNQQILKDQVKKEEEELKKEFIEKEA 1216

Query: 1499 Q--STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK 1556
            +  S  +E EV   K+E  + K+  +     E    +  + +  +    E  KQ ++L  
Sbjct: 1217 KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRG 1276

Query: 1557 KLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-----KEQAAEHYK 1611
            ++A  +   +  Q + +A+  +  + + E ++LQ ++ ELQ +L       +E   E+  
Sbjct: 1277 EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336

Query: 1612 LQMEKAKTHYDAKKQQNQELQ 1632
            LQ++  +   + K  ++ E+Q
Sbjct: 1337 LQIKHTQA-LNRKWAEDNEVQ 1356



 Score =  191 bits (484), Expect = 8e-48
 Identities = 286/1332 (21%), Positives = 558/1332 (41%), Gaps = 169/1332 (12%)

Query: 436  VEMLETERGQQEAKLLAERGHFEEEKQQLSS-------------LITDLQSSISNLSQAK 482
            V +L  E    +A L  E+ + EE K++L               L+TD  + + +L Q  
Sbjct: 85   VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144

Query: 483  EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ 542
            EE  Q    +  ++        ++L T  A I+ +  E   L++ A++K  +L + L ++
Sbjct: 145  EEA-QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203

Query: 543  EQASQGLRHQVEQLS-----SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597
                Q L+ ++ Q       + LK++  Q++ + +     R+  +++L    ++ ++   
Sbjct: 204  ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263

Query: 598  ERDAALKQLEAL----EKEKAAKLEILQQQLQVANEARDSAQT---SVTQAQREKAELSR 650
              +A + QL +      +E A  ++ LQ+     NE     QT   ++ + +++  +L  
Sbjct: 264  SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323

Query: 651  KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
            K  E     +  +   H+      +L+ +L + +   T   R+  E  +  E  Q LKE 
Sbjct: 324  KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASE---TSLHRIHVELSEKGEATQKLKEE 380

Query: 711  LKVTKGS---LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767
            L   +     L+ E ++     EE+++   +L++E   L        K LE ER      
Sbjct: 381  LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL------HSKLLETER------ 428

Query: 768  EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY 827
                 QLGEAH    E  +R+L+             EQ V ++     R E+  +E+   
Sbjct: 429  -----QLGEAHGRLKE--QRQLSSEKLMDK------EQQVADLQLKLSRLEEQLKEKVTN 475

Query: 828  GAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQ 887
                Q QL       +K +Q+ QE +     ++  +  ++   QN+L ++   +    Q+
Sbjct: 476  STELQHQL-------DKTKQQHQEQQ----ALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524

Query: 888  VQEKEVRAQKLADDLSTLQE-------KMAATSKEVARLETLVRKAGEQQETASR--ELV 938
            +Q  E   QK  +++S L++       K+ A   E A L  L  K    QE  ++  E +
Sbjct: 525  IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584

Query: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998
            K  + +  +  E L +Q   Q    +A L+A +     +   +  L + L ES+    E+
Sbjct: 585  KNQSESHKQAQENLHDQVQEQ----KAHLRAAQDRVLSLETSVNELNSQLNESK----EK 636

Query: 999  RGQQEREVARLTQERGRAQADLALEKAARAELEMRL---QNALNEQRVEFATLQEALAHA 1055
              Q + ++   T+    A+A    + A RA+L+  L   QNAL +++ E   +   L   
Sbjct: 637  VSQLDIQIKAKTELLLSAEA---AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693

Query: 1056 LTEKEGKDQELAKLRGLEAAQIKELEE----LRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
              + + K +  ++L     + +KE +E    L Q  ++L+ Q+ K E +      ++ +A
Sbjct: 694  TAKLQDKQEHCSQLE----SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749

Query: 1112 AG--------------RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR 1157
                            R      +LE  +  VS      QK+ E  +S+++ L  +   +
Sbjct: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809

Query: 1158 AERDSALETLQGQLEEKAQELGH----SQSALASAQRELAAFRTK---VQDH-SKAEDEW 1209
                   ETL  + + + +EL +    + + L   + E  A  T+   V+D  SK  D  
Sbjct: 810  QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL 869

Query: 1210 KAQVARGRQEAERKNSLISSLEEEVSILNRQV-LEKEG---ESKELKRLVMAESEKSQKL 1265
            K   +   +E ++  + I  LE+    L  Q+ ++ E    E KELK+ +  E E S +L
Sbjct: 870  KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929

Query: 1266 EERLRLLQAET--ASNSARAAERSSA-LREEVQSLREEAEKQRVASENLRQELTSQAERA 1322
            +  L  +Q +   A N+ +  E+    L+  +  L++ +E+++   E L+ EL     + 
Sbjct: 930  KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989

Query: 1323 EELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR 1382
             EL  +L+       Q  QA   L  E      L +    ++   +QLQ++    E    
Sbjct: 990  TELENKLQQ------QLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES--- 1040

Query: 1383 EELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
             EL  ++Q    +  +L  AQ +L   I  R ++  Q +  Q+L+  KA+  EQ S  K+
Sbjct: 1041 -ELLATRQDLKSVEEKLSLAQEDL---ISNRNQIGNQNKLIQELKTAKATL-EQDSAKKE 1095

Query: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502
                L E  + L +     +   E EL   + K + E+  ++   E  + ++  E +S  
Sbjct: 1096 QQ--LQERCKALQD-IQKEKSLKEKELVNEKSK-LAEIEEIKCRQEKEITKLNEELKSHK 1151

Query: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562
             E        + AK  +++++   Q +   L A VEQ         K+ +++ K     D
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ--------EKRNQQILK-----D 1198

Query: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYD 1622
            Q  K +++  K       E  ++  +L +++ E +  + + E+      +Q+     +  
Sbjct: 1199 QVKKEEEELKK-------EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251

Query: 1623 AKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS 1682
              K++ Q  Q   R + +L+K+  +LR E   L   +Q    + +   + C     ++  
Sbjct: 1252 TVKKEWQSSQ---RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK 1308

Query: 1683 LEAQVAHADQQL 1694
            L+ +V    ++L
Sbjct: 1309 LQTKVLELQRKL 1320



 Score =  186 bits (473), Expect = 2e-46
 Identities = 253/1149 (22%), Positives = 497/1149 (43%), Gaps = 178/1149 (15%)

Query: 172  SHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQ-MRRLKKQLADERSNR 230
            S + K E + L+ Q  +S ++ +   S     P    +   + Q ++    +L  +    
Sbjct: 248  SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307

Query: 231  DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290
             E  L+  ++   L EK  + ++ ++ I   A L++K     L+ ++L+     +E+   
Sbjct: 308  TENLLKKEQDYTKLEEKHNEESVSKKNIQ--ATLHQKD----LDCQQLQSRLSASETSLH 361

Query: 291  RLHETLKQ----CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTE 346
            R+H  L +     Q LK E S+++ K   L  E   L  +  E   H  QLQ  +N+L  
Sbjct: 362  RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS 421

Query: 347  EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEI--LQGKLSQLEEHLSQ-------- 396
            +  +  ++  E   +L+++    L  +K ++++ ++  LQ KLS+LEE L +        
Sbjct: 422  KLLETERQLGEAHGRLKEQRQ--LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479

Query: 397  ----------------LQDNPPQEKGEVLGD----VLQLETLKQEAATLAANNTQLQARV 436
                            LQ +   +  E   D    + Q+    Q+   L A   + +  +
Sbjct: 480  QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539

Query: 437  EMLETERGQQEAKLLAERG------HFEEEKQQLSSLITDLQSSISNLS----QAKEELE 486
             +LE ER    AK+ A  G        +E+   L   +T L   + N S    QA+E L 
Sbjct: 540  SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599

Query: 487  QASQAHGARLTA---QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
               Q   A L A   +V SL + +  LN+ + +  ++++ L  Q K K   L      + 
Sbjct: 600  DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659

Query: 544  QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT------RQDHAQQLATAAEE------ 591
                 L++ ++   ++L+ K+Q+L ++  + +        +Q+H  QL +  +E      
Sbjct: 660  AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719

Query: 592  -REASLRERDAALKQLEA----LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK- 645
              E    E +  +K+LEA    ++  K   L+ LQQQ Q+  +    A     Q + EK 
Sbjct: 720  SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779

Query: 646  ------AELSRKVEELQACVETARQEQHEAQA-----QVAELELQLRSE------QQKAT 688
                   +L +K E L++  +   +++ E Q      +    E +++ E      Q   T
Sbjct: 780  IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839

Query: 689  EKERVAQEKDQLQEQLQALK-------ESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
            E ++V  EK+ L  +L  +K       +SLK +K   E+E ++   A+ + ++   ELK 
Sbjct: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899

Query: 742  ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEV--LRRELAEAMAAQHTA 799
            + +  +E   +E+KEL      +K LE   ++   +HQ + E+  ++ +L +A       
Sbjct: 900  QLQVQMENTLKEQKEL------KKSLE---KEKEASHQLKLELNSMQEQLIQAQNTLKQN 950

Query: 800  ESECEQL------VKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-LKEECEKARQELQEA 852
            E E +QL      +K+ +  +++  ++ Q E +   + + +L   L+++  +A QEL   
Sbjct: 951  EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010

Query: 853  KEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
            KEK++ ++++ E    + Q    +L ++      ++       + + + LS  QE + + 
Sbjct: 1011 KEKISVLQNNYE----KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066

Query: 913  SKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
              ++     L+    ++ +TA   L ++ A+         +EQQ ++ C    ALQ +++
Sbjct: 1067 RNQIGNQNKLI----QELKTAKATLEQDSAK---------KEQQLQERCK---ALQDIQK 1110

Query: 973  EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD-----LALEKAAR 1027
            E      EL   ++ L E     +E + +QE+E+ +L +E    + +       L+ A +
Sbjct: 1111 EKSLKEKELVNEKSKLAEI----EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ 1166

Query: 1028 AELEMRLQNALNEQRVEFATLQEAL-AHALTEKEGKDQELAKLRGLEA-----AQIKELE 1081
              ++ +L+       ++ A  QE      L ++  K++E  K   +E      ++IKE E
Sbjct: 1167 LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226

Query: 1082 -----------ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
                       +L   +  L E L   +KE  S     SE   +T+        LR E++
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD-------LRGEIA 1279

Query: 1131 KLEQQCQKQQEQADS-LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
             LE   Q  Q++  + LER L+ E          +E LQ ++ E  ++L ++ +A+    
Sbjct: 1280 VLEATVQNNQDERRALLERCLKGE--------GEIEKLQTKVLELQRKLDNTTAAVQELG 1331

Query: 1190 RELAAFRTK 1198
            RE  + + K
Sbjct: 1332 RENQSLQIK 1340



 Score =  177 bits (449), Expect = 1e-43
 Identities = 238/1117 (21%), Positives = 471/1117 (42%), Gaps = 146/1117 (13%)

Query: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
            N++    ++++   + +   L ++V++LQA +   ++E+  ++    ELE     +QQ+A
Sbjct: 68   NDSGHGGESNLALKRDDVTLLRQEVQDLQASL---KEEKWYSEELKKELEKYQGLQQQEA 124

Query: 688  TEKERVAQEKDQLQEQLQALKE------SLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
                 V     +LQ   Q L+E      ++K  K   E++  + A  + + +    E ++
Sbjct: 125  KPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERS 184

Query: 742  ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT--- 798
               +  ++  R  +EL +E    + L+  L Q       +  VL++EL +          
Sbjct: 185  LREAAEQKVTRLTEELNKEATVIQDLKTELLQ--RPGIEDVAVLKKELVQVQTLMDNMTL 242

Query: 799  -AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
              E E E+L  E    + +Y  S+   +Q     + +L    +E     QELQ+ K  V 
Sbjct: 243  ERERESEKLKDECKKLQSQYASSEATISQ----LRSELAKGPQEVAVYVQELQKLKSSVN 298

Query: 858  GIESHSE------LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL--STLQEKM 909
             +   ++      L+  +   +L E H       + V +K ++A     DL    LQ ++
Sbjct: 299  ELTQKNQTLTENLLKKEQDYTKLEEKHNE-----ESVSKKNIQATLHQKDLDCQQLQSRL 353

Query: 910  AATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQA 969
            +A+   + R+   + + GE  +    EL +   +    + E+ + QQ R         + 
Sbjct: 354  SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR---------EE 404

Query: 970  MEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
             E+   Q+ +E+ +L + L+E++ Q  E  G       RL ++R  +   L  ++   A+
Sbjct: 405  KEQHGLQLQSEINQLHSKLLETERQLGEAHG-------RLKEQRQLSSEKLMDKEQQVAD 457

Query: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
            L+++L + L EQ  E  T    L H L + + + QE    + L+ +   +L E +  ++Q
Sbjct: 458  LQLKL-SRLEEQLKEKVTNSTELQHQLDKTKQQHQE---QQALQQSTTAKLREAQNDLEQ 513

Query: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
            +  Q+  K++                            ++  LE   QK +E    LE+ 
Sbjct: 514  VLRQIGDKDQ----------------------------KIQNLEALLQKSKENISLLEKE 545

Query: 1150 LEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
             E +  ++ +       +  QL+EK   L    + L          + + + H +A++  
Sbjct: 546  RE-DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE------KLKNQSESHKQAQENL 598

Query: 1210 KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERL 1269
              QV   +         + SLE  V+ LN Q+ E + +  +L   + A++E         
Sbjct: 599  HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE--------- 649

Query: 1270 RLLQAETASNSARA--AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ 1327
             LL AE A  + RA         +  +Q  ++E  K     + +  +L  + E   +L  
Sbjct: 650  LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709

Query: 1328 ELKAWQEKFFQKEQALSTLQ-----LEHTSTQALVSELLPAKHLCQ--QLQAEQAAAEKR 1380
             LK ++EK+   EQ    L+     LE  S +   S+    + L Q  QL  +       
Sbjct: 710  HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769

Query: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1440
              ++LE  K+     R +L   Q++   L  ++QK+ +QE              E+  +L
Sbjct: 770  LSKQLEMEKEIVSSTRLDL---QKKSEALESIKQKLTKQE--------------EEKQIL 812

Query: 1441 KKAHGLLAEENRGLGERANLGRQFLEVELDQA---REKYVQELAAVRADAETRLAEVQRE 1497
            K+    L++E +   E  N   Q    EL +    +E  + EL+ V+     +L++V   
Sbjct: 813  KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK----DKLSKVSDS 868

Query: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557
             +++  E E    K    K  +L+  +  +E + +L  Q+E          K+ +EL K 
Sbjct: 869  LKNSKSEFEKENQK---GKAAILDLEKTCKELKHQLQVQME-------NTLKEQKELKKS 918

Query: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617
            L    +AS   + +L ++Q Q  ++Q   ++ + +  +LQ  +++ +Q++E  K Q+E  
Sbjct: 919  LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978

Query: 1618 KTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLT 1677
            +        Q  EL+ +L+  +QL +  +EL AE E++   LQ      +++++T + L 
Sbjct: 979  QGELKIAVLQKTELENKLQ--QQLTQAAQELAAEKEKIS-VLQN---NYEKSQETFKQLQ 1032

Query: 1678 AQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQ 1713
            +     E+++    Q L+ +  K  +A + L S   Q
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069



 Score =  100 bits (250), Expect = 1e-20
 Identities = 153/734 (20%), Positives = 317/734 (43%), Gaps = 87/734 (11%)

Query: 81   LVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDG 140
            L +AQ  L+  + EL K+T  L       +   +D ++   ++++ L    +  L  E  
Sbjct: 669  LDTAQNALQDKQQELNKITTQL----DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724

Query: 141  LNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKR-----EIRF------LELQKVAS 189
                E+LE  ++K    S       E+      Q ++     E+R       LE++K   
Sbjct: 725  ---TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781

Query: 190  SSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENR-------- 241
            SS+  +    S A        T Q + +++ KQ  +  S   +++ E   NR        
Sbjct: 782  SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841

Query: 242  -KLLTEKDAQIAMMQQRIDRLALLNE--KQAASPLEPK---------ELEEL-RDKNESL 288
             K+  EK+A +  +    D+L+ +++  K + S  E +         +LE+  ++    L
Sbjct: 842  QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901

Query: 289  TMRLHETLKQCQDLKTE-------KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDAL 341
             +++  TLK+ ++LK           Q+  ++N + E+       L++     QQLQ  +
Sbjct: 902  QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961

Query: 342  NELTEEHSK--------------ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
            NEL +   +              A  +  E + +L+++L+ A Q+    +EK  +LQ   
Sbjct: 962  NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAA----TLAANNTQLQARVEMLETER 443
             + +E   QLQ +    + E+L     L++++++ +     L +N  Q+  + ++++ E 
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ-EL 1080

Query: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503
               +A L  +    E++ Q+    + D+Q   S   + KE + + S+   A +       
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKS--LKEKELVNEKSKL--AEIEEIKCRQ 1136

Query: 504  TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563
              E+T LN  +  +  +L  +K+    K A+  Q L QQ+   QG    ++      K+ 
Sbjct: 1137 EKEITKLNEEL--KSHKLESIKEITNLKDAK--QLLIQQKLELQGKADSLKAAVEQEKRN 1192

Query: 564  EQQLKEVAEKQEATRQDHAQQLATAAEEREASL----RERDAALKQLEALEKEKAAKLEI 619
            +Q LK+  +K+E       ++L     E+EA L    +E++  +K+ E  E +   ++  
Sbjct: 1193 QQILKDQVKKEE-------EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245

Query: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679
            L + L    +   S+Q  V++ +++  +L  ++  L+A V+  + E+     +  + E +
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305

Query: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739
            +   Q K  E +R         ++L    +SL++ K +    ++ A D   E Q C++  
Sbjct: 1306 IEKLQTKVLELQRKLDNTTAAVQELGRENQSLQI-KHTQALNRKWAED--NEVQNCMACG 1362

Query: 740  KAETRSLVEQHKRE 753
            K  + ++   H R+
Sbjct: 1363 KGFSVTVRRHHCRQ 1376


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  208 bits (530), Expect = 4e-53
 Identities = 260/1145 (22%), Positives = 485/1145 (42%), Gaps = 108/1145 (9%)

Query: 269  AASPLEPKELEEL-----RDKNESLTM------RLHETLKQCQDLKTEKSQMDRKINQLS 317
            AA+  + +ELEE      ++KN+           L +  ++C  L   K Q++ K+ +LS
Sbjct: 913  AAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELS 972

Query: 318  EENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE 377
            E   D      + A+  ++L+D   EL     K   +     A+ EKE  A     K L 
Sbjct: 973  ERLEDEEEVNADLAARRRKLEDECTEL----KKDIDDLKLTLAKAEKEKQATENKVKNLT 1028

Query: 378  EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
            E+   L   +++L +    LQ+   Q  G+     LQ E  +  A T A    +L+ +VE
Sbjct: 1029 EEMAALDESVARLTKEKKALQEAHQQALGD-----LQAEEDRVSALTKA--KLRLEQQVE 1081

Query: 438  MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
             LE    +QE KL   R   E  K++L   +   Q S+++ +Q K++LE+          
Sbjct: 1082 DLECSL-EQEKKL---RMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE---------- 1127

Query: 498  AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVE-- 554
             ++    SEL+ L  +++ +D++L G + Q K K+ Q  A+ L+++ +A +  R +VE  
Sbjct: 1128 -KLKKKDSELSQL--SLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQ 1184

Query: 555  --QLSSSLKQKEQQLKEV----AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA 608
              + +  L++  ++L+E     A ++E  R+  A+      E  EA+LR  +A +  L  
Sbjct: 1185 RAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR-HEATVAALRR 1243

Query: 609  LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668
             + E AA+L           E  DS Q    + ++EK+EL  +V++L A VET  + +  
Sbjct: 1244 KQAEGAAEL----------GEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKAS 1293

Query: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
            A+      E QL   + K               E+LQ         +G L+ E    +  
Sbjct: 1294 AEKLCRTYEDQLSEAKIKV--------------EELQRQLADASTQRGRLQTESGELSRL 1339

Query: 729  LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
            LEE++  IS+L        +  +  R++LEEE   +  L   +Q L    + + ++LR +
Sbjct: 1340 LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQAL----RHDCDLLREQ 1395

Query: 789  LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQ- 847
              E   AQ   +    +   EVA WR +YE    +  +     +++L    +E E+  + 
Sbjct: 1396 HEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEA 1455

Query: 848  ------ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901
                   L++AK ++        L++ R  +  A L        + ++E+  + +++  +
Sbjct: 1456 ANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRE 1515

Query: 902  LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFC 961
            L   Q +      E+ RL     +A E  ET  RE         D            Q  
Sbjct: 1516 LEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD---------QVS 1566

Query: 962  STQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA 1021
             +  ++Q +E+  + +  E   ++AAL E++G  + E  +  R    L+Q +      LA
Sbjct: 1567 LSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLA 1626

Query: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
             +    A L    Q A+   +        A   AL  K+  + +L  L        ++  
Sbjct: 1627 EKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAT 1686

Query: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
            E +   + ++ QL    KE  +G   +   A         LE   + ++   ++ +   E
Sbjct: 1687 EAQAATRLMQAQL----KEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1742

Query: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
            Q +   R  E E     ER + L +    L  + ++L    + L+    E A  R + ++
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE 1802

Query: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261
             +K      A +A   +E +++    + LE     L + V E +   +E ++  +   +K
Sbjct: 1803 KAKKAITDAAMMA---EELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKK 1859

Query: 1262 S-QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1320
              QKLE ++R L+AE  +   + AE    +R+  + ++E A +    +E  R+ L    +
Sbjct: 1860 QVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQ----AEEDRKNLARMQD 1915

Query: 1321 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
              ++L  ++K+++ +F + EQ  +T   ++   Q    EL  A+      + +      R
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQ---HELDDAEERADMAETQANKLRAR 1972

Query: 1381 HREEL 1385
             R+ L
Sbjct: 1973 TRDAL 1977



 Score =  196 bits (499), Expect = 2e-49
 Identities = 283/1143 (24%), Positives = 481/1143 (42%), Gaps = 155/1143 (13%)

Query: 449  KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT 508
            K L      EEE   L + +  L+ +++     ++ELE+   +           L +E  
Sbjct: 886  KPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQD 945

Query: 509  TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL---RHQVEQLSSSLKQKEQ 565
             L A  +++   L   K Q + K  +L++ L+ +E+ +  L   R ++E   + LK+   
Sbjct: 946  NL-ADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDID 1004

Query: 566  QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQQL 624
             LK    K E  +Q        A E +  +L E  AAL +  A L KEK A  E  QQ L
Sbjct: 1005 DLKLTLAKAEKEKQ--------ATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQAL 1056

Query: 625  Q--VANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
                A E R SA T      + K  L ++VE+L+  +E  ++ + + +    +LE  L+ 
Sbjct: 1057 GDLQAEEDRVSALT------KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKL 1110

Query: 683  EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
             Q+   +    AQ+K QL+E+L+     L      +E+E+   A    + Q+ I EL+A 
Sbjct: 1111 TQESVAD---AAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA----QMQKKIKELQAR 1163

Query: 743  TRSLVEQHKRERK---ELEEERAGR----KGLEARLQQLGEA----------HQAETEVL 785
               L E+ + ER     +E++RA      + L  RL++ G A           +AE   L
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRL 1223

Query: 786  RRELAEAMAAQHTAE------------SECEQLVKEVAAWRERYEDSQQE---EAQYGAM 830
            RREL EA A +H A             +E  + V  +   R++ E  + E   E    A 
Sbjct: 1224 RRELEEA-ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA 1282

Query: 831  FQEQLMTLKEECEKA----RQELQEAKEKVAGIE---SHSELQISRQQNELAELHANLAR 883
              E L   K   EK       +L EAK KV  ++   + +  Q  R Q E  EL   L  
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEE 1342

Query: 884  A----LQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL------VRKAGEQQETA 933
                  Q  + K + AQ L +    L+E+  A S     ++ L      +R+  E++  A
Sbjct: 1343 KECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA 1402

Query: 934  SRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 993
              EL +  ++A     +W  + +      T+   +A ++ A ++    E + AA  +   
Sbjct: 1403 QAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSS 1462

Query: 994  QQQEE-RGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052
             ++ + R Q E E   L  ER  + A  AL+K  R      L+ AL E+R +   +Q  L
Sbjct: 1463 LEKAKLRLQTESEDVTLELERATSAA-AALDKKQR-----HLERALEERRRQEEEMQREL 1516

Query: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA----------------- 1095
              A  E  G   EL +LR      ++ LE L++  K L+E+++                 
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELE 1576

Query: 1096 --KK--EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL-----------EQQC---- 1136
              KK  E E +    A  EA G  E    K   ++ E+S++           +++C    
Sbjct: 1577 KTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR 1636

Query: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
            +  Q   +SL+ SL+AE  +R E     + ++G L +   +LGH+      AQ      +
Sbjct: 1637 RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQ 1696

Query: 1197 TKVQDHSKAEDEWK---AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
             ++++     DE +   A++    Q  ER+ SL+++  EE+    R  LE+   S+ L  
Sbjct: 1697 AQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL----RAALEQGERSRRLAE 1752

Query: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313
              + E+       ERL LL ++      +  +  + L +    + E A+++R A E  ++
Sbjct: 1753 QELLEA------TERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKK 1806

Query: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE-----LLPAKHLCQ 1368
             +T  A  AEEL +E    Q+     E+   TL+      QA + E     L   K   Q
Sbjct: 1807 AITDAAMMAEELKKE----QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQ 1862

Query: 1369 QLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA 1428
            +L+A+    E     E ++  +A  G+R    R +    +    R+ +A  +    +L++
Sbjct: 1863 KLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQS 1922

Query: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY-VQELAAVRADA 1487
            +  SY  Q    ++      + N  L +         + ELD A E+  + E  A +  A
Sbjct: 1923 KVKSYKRQFEEAEQ------QANTNLAKYRK-----AQHELDDAEERADMAETQANKLRA 1971

Query: 1488 ETR 1490
             TR
Sbjct: 1972 RTR 1974



 Score =  193 bits (490), Expect = 2e-48
 Identities = 274/1161 (23%), Positives = 489/1161 (42%), Gaps = 141/1161 (12%)

Query: 516  QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
            Q ++ELA L+ + +  +  LA        A++  R ++E+   S+ Q++  L    + ++
Sbjct: 893  QAEEELAALRAELRGLRGALA--------AAEAKRQELEETHVSITQEKNDLALQLQAEQ 944

Query: 576  ---ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
               A  ++    L  +  + E  ++E    L+  E +  + AA+   L+ +     +  D
Sbjct: 945  DNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDID 1004

Query: 633  SAQTSVTQAQREKAELSRKV----EELQACVETARQEQHEAQA-----QVAELELQLRSE 683
              + ++ +A++EK     KV    EE+ A  E+  +   E +A     Q A  +LQ   +
Sbjct: 1005 DLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEED 1064

Query: 684  QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
            +  A  K ++  E  Q  E L+   E  K  +   E  KR+    L+  Q  +++   + 
Sbjct: 1065 RVSALTKAKLRLE--QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDK 1122

Query: 744  RSLVEQHKRERKELEE---ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
            + L E+ K++  EL +        + L A++Q+  +  QA  E L  EL    AA+   E
Sbjct: 1123 QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVE 1182

Query: 801  SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
             +  +  +E+    ER E++    A      +E     + E  + R+EL+EA  +     
Sbjct: 1183 KQRAEAARELEELSERLEEAGGASAGQ----REGCRKREAELGRLRRELEEAALRHEATV 1238

Query: 861  SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS----TLQEKMAATSKEV 916
            +    + +    EL E   +L R  Q++++++   +   DDL+    TL    A+  K  
Sbjct: 1239 AALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLC 1298

Query: 917  ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ 976
               E  + +A  + E   R+L     + G  Q E                L  +  E E 
Sbjct: 1299 RTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE-------------SGELSRLLEEKEC 1345

Query: 977  MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA-LEKAARAELEMRLQ 1035
            + ++L R +A   +S             E+ R  +E  +A++ LA   +A R + ++   
Sbjct: 1346 LISQLSRGKALAAQSL-----------EELRRQLEEESKAKSALAHAVQALRHDCDL--- 1391

Query: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQLKEQL 1094
              L EQ  E A  Q  L   L++      E+A+ R   EA  I+  EEL +  K+L  +L
Sbjct: 1392 --LREQHEEEAEAQAELQRLLSKANA---EVAQWRSKYEADAIQRTEELEEAKKKLALRL 1446

Query: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154
             + E+                      +EA  A+ S LE+   + Q +++ +   LE   
Sbjct: 1447 QEAEEG---------------------VEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485

Query: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214
            ++ A  D     L+  LEE+ ++    Q  L +AQRE     T++       +E    + 
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545

Query: 1215 RGRQEAERKNSLISSLEEEVSILNRQV--LEK-----EGESKELKRLVMAESEKSQKLEE 1267
              ++E +     IS L ++VS+  + +  LEK     EGE  E++   + E+E + +LEE
Sbjct: 1546 TLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQA-ALEEAEGALELEE 1604

Query: 1268 RLRL-LQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG 1326
               L +Q E +   A    + +   EE  +LR   ++   A E+L+  L ++     E  
Sbjct: 1605 TKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQR---AVESLQASLDAETRARNEAL 1661

Query: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ-QLQAEQAAAEKRHREEL 1385
            +  K  +      E     LQL H + QA  +E   A  L Q QL+ EQA  ++  R   
Sbjct: 1662 RLKKKMEGDLNDLE-----LQLGHATRQA--TEAQAATRLMQAQLKEEQAGRDEEQRLAA 1714

Query: 1386 EQSKQA-AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
            E  +QA A   RA LL A     EL  LR  + + ER+ +    E     E+L++L   +
Sbjct: 1715 ELHEQAQALERRASLLAA-----ELEELRAALEQGERSRRLAEQELLEATERLNLLHSQN 1769

Query: 1445 -GLLAEENRGLGERANLGRQFLEV-----ELDQAREKYVQELAAV------RADAETRLA 1492
             GLL ++ +   + A L  +  E      E ++  +K + + A +        D    L 
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1829

Query: 1493 EVQREAQSTAREL-----EVMTAKYEGAKVKVLEERQRFQEERQKLTAQ----------V 1537
             +++  + T REL     E   A   G K +V +   + +E   +L A+          V
Sbjct: 1830 RMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGV 1889

Query: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597
             + E   +E   Q EE  K LA         Q K+K+ + Q  E++Q+A    A+  + Q
Sbjct: 1890 RKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQ 1949

Query: 1598 AQLSQKEQAAEHYKLQMEKAK 1618
             +L   E+ A+  + Q  K +
Sbjct: 1950 HELDDAEERADMAETQANKLR 1970



 Score =  189 bits (480), Expect = 2e-47
 Identities = 267/1137 (23%), Positives = 491/1137 (43%), Gaps = 150/1137 (13%)

Query: 640  QAQREKAELSRKVEELQ---ACVETARQEQHEAQAQVAE----LELQLRSEQQKATEKER 692
            QA+ E A L  ++  L+   A  E  RQE  E    + +    L LQL++EQ    + E 
Sbjct: 893  QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952

Query: 693  ----VAQEKDQLQEQLQALKESLK---VTKGSLEEEKRRAADALEEQQRCISELKAETRS 745
                + + K QL+ +++ L E L+        L   +R+  D   E ++ I +LK  T +
Sbjct: 953  RCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL-TLA 1011

Query: 746  LVEQHKRER----KELEEERAGRKGLEARLQQ----LGEAHQAETEVLRRELAEAMAAQH 797
              E+ K+      K L EE A      ARL +    L EAHQ     L+ E  + ++A  
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAE-EDRVSALT 1070

Query: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
             A+   EQ V+++    E+ +  + +  +     +  L   +E    A Q+ Q+ +EK+ 
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1130

Query: 858  GIESH-SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
              +S  S+L +  +  +L       A+  ++++E + RA++L ++L   +   A   K+ 
Sbjct: 1131 KKDSELSQLSLRVEDEQLLG-----AQMQKKIKELQARAEELEEELEAERAARARVEKQR 1185

Query: 917  ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFC-STQAALQAMEREAE 975
            A     + +  E+ E A        A AG R+            C   +A L  + RE E
Sbjct: 1186 AEAARELEELSERLEEAGG------ASAGQREG-----------CRKREAELGRLRRELE 1228

Query: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE------------ 1023
            +     E   AAL   Q +   E G+Q   + R+ Q+  + +++L +E            
Sbjct: 1229 EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLT 1288

Query: 1024 --KAARAELEMRLQNALNEQRVEFATLQEALAHALTEK---EGKDQELAKLRGLEAAQIK 1078
              KA+  +L    ++ L+E +++   LQ  LA A T++   + +  EL++L   +   I 
Sbjct: 1289 RAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLIS 1348

Query: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQK 1138
            +L   +    Q  E+L ++ +E +    A + A          ++ALR +   L +Q ++
Sbjct: 1349 QLSRGKALAAQSLEELRRQLEEESKAKSALAHA----------VQALRHDCDLLREQHEE 1398

Query: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA-LASAQRELAAFRT 1197
            + E    L+R L    A  A+  S  E    Q  E+ +E     +  L  A+  + A   
Sbjct: 1399 EAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA 1458

Query: 1198 KVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
            K     KA+   + +      E ER  S  ++L+++   L R + E+  + +E++R + A
Sbjct: 1459 KCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEA 1518

Query: 1258 ESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS 1317
               +S+ L   L  L+         A E    L+ E ++L+EE         +L  +++ 
Sbjct: 1519 AQRESRGLGTELFRLR----HGHEEALEALETLKRENKNLQEEIS-------DLTDQVSL 1567

Query: 1318 QAERAEELGQELKAWQEKFFQKEQALS----TLQLEHTSTQALVSELLPAKHLCQQLQAE 1373
              +  +EL +  KA + +  + + AL      L+LE T T  +  EL   K    +  AE
Sbjct: 1568 SGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAE 1627

Query: 1374 Q----AAAEKRHR---EELEQSKQAAGGLRAELLRAQREL-GELIPLRQKVAEQERTAQ- 1424
            +    A   + H+   E L+ S  A    R E LR ++++ G+L  L  ++    R A  
Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATE 1687

Query: 1425 ----------QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474
                      QL+ E+A   E+  +  + H    E+ + L  RA+L    L  EL++ R 
Sbjct: 1688 AQAATRLMQAQLKEEQAGRDEEQRLAAELH----EQAQALERRASL----LAAELEELRA 1739

Query: 1475 KYVQELAAVRADAETRLAEVQR----EAQSTA-----RELEVMTAKYEGAKVKVLEERQR 1525
               Q   + R   +  L   +R     +Q+T      ++LE   A+  G   +  +ER+ 
Sbjct: 1740 ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERRE 1799

Query: 1526 FQEERQK-LTAQVEQLEVFQREQ--TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGES 1582
             +E+ +K +T      E  ++EQ  +  +E + K L  + +  + + ++ +    +GG+ 
Sbjct: 1800 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKK 1859

Query: 1583 QQEAQRLQAQLNELQAQL--SQKEQA------AEHYKLQMEKAKTHYDAKKQ--QNQELQ 1632
            Q   Q+L+A++ EL+A+L   QK+ A       +H +   E A    + +K   + Q+L 
Sbjct: 1860 Q--VQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLV 1917

Query: 1633 EQL--------RSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR 1681
            ++L        R  E+ +++     A+  +  HEL  A  +   AE     L A+ R
Sbjct: 1918 DKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTR 1974



 Score =  186 bits (472), Expect = 2e-46
 Identities = 239/1028 (23%), Positives = 438/1028 (42%), Gaps = 121/1028 (11%)

Query: 754  RKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT----AESECEQLVK- 808
            R EL   R      EA+ Q+L E H + T+  + +LA  + A+      AE  C  L+K 
Sbjct: 902  RAELRGLRGALAAAEAKRQELEETHVSITQE-KNDLALQLQAEQDNLADAEERCHLLIKS 960

Query: 809  ------EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH 862
                  +V    ER ED ++  A   A  ++    L++EC + ++++ + K  +A  E  
Sbjct: 961  KVQLEGKVKELSERLEDEEEVNADLAARRRK----LEDECTELKKDIDDLKLTLAKAEKE 1016

Query: 863  SELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL 919
             +   ++ +N   E+A L  ++AR  ++ +  +   Q+   DL   +++++A +K   RL
Sbjct: 1017 KQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRL 1076

Query: 920  ETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGN 979
            E  V     +    S E  K+     +R    LE         TQ ++    ++ +Q+  
Sbjct: 1077 EQQV-----EDLECSLEQEKKLRMDTERAKRKLEGD----LKLTQESVADAAQDKQQLEE 1127

Query: 980  ELERLRAALMESQGQQQEER---GQQEREVARLTQERGRAQADLALEKAARAELEMRLQN 1036
            +L++  + L +   + ++E+    Q ++++  L       + +L  E+AARA +E +   
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187

Query: 1037 ALNEQRVEFATLQEALAHALTEKEG---KDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
            A  E       L+EA   +  ++EG   ++ EL +LR       +ELEE     +     
Sbjct: 1188 AARELEELSERLEEAGGASAGQREGCRKREAELGRLR-------RELEEAALRHEATVAA 1240

Query: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
            L +K+ E A+  G Q ++  R                KLE++  + + + D L  ++E  
Sbjct: 1241 LRRKQAEGAAELGEQVDSLQRVR-------------QKLEKEKSELRMEVDDLAANVETL 1287

Query: 1154 RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK--- 1210
              ++A  +    T + QL E   ++   Q  LA A  +    +T+  + S+  +E +   
Sbjct: 1288 TRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLI 1347

Query: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
            +Q++RG+  A +      SLEE    L RQ+ E+      L   V A       L E+  
Sbjct: 1348 SQLSRGKALAAQ------SLEE----LRRQLEEESKAKSALAHAVQALRHDCDLLREQ-- 1395

Query: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVA-SENLRQELTSQAERAEELGQEL 1329
                E A   A      S    EV   R + E   +  +E L +     A R +E  + +
Sbjct: 1396 --HEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV 1453

Query: 1330 KAWQEKFFQKEQALSTLQLE--------HTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
            +A   K    E+A   LQ E          +T A  +     +HL + L+ E+   E+  
Sbjct: 1454 EAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE-ERRRQEEEM 1512

Query: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
            + ELE +++ + GL  EL R +    E +   + +  + +  Q+   E +   +Q+S+  
Sbjct: 1513 QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQE---EISDLTDQVSLSG 1569

Query: 1442 KAHGLLAEENRGL-GERANLGRQFLE----VELDQAREKYVQ-ELAAVRADAETRLAEVQ 1495
            K+   L +  + L GE++ +     E    +EL++ +   +Q EL+ V+A+ + +LAE  
Sbjct: 1570 KSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKD 1629

Query: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE-- 1553
             E  +  R  +      + +       R      ++K+   +  LE+     T+Q  E  
Sbjct: 1630 EECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQ 1689

Query: 1554 ----LSKKLADSDQASKVQQQKLKA-VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608
                L +     +QA + ++Q+L A +  Q    ++ A  L A+L EL+A L Q E++  
Sbjct: 1690 AATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1749

Query: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE 1668
              + ++ +A    +    QN  L  Q + LE    +  +L  E E    E ++A  K K+
Sbjct: 1750 LAEQELLEATERLNLLHSQNTGLLNQKKKLEA---DLAQLSGEVEEAAQERREAEEKAKK 1806

Query: 1669 A--------------EQTCRHLTAQ-------VRSLEAQVAHADQQLRDLGKFQVATDAL 1707
            A              + T  HL          VR L+A++  A+Q     GK QV     
Sbjct: 1807 AITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEA 1866

Query: 1708 KSREPQAK 1715
            K RE +A+
Sbjct: 1867 KVRELEAE 1874



 Score =  155 bits (392), Expect = 4e-37
 Identities = 228/922 (24%), Positives = 403/922 (43%), Gaps = 119/922 (12%)

Query: 850  QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM 909
            ++A EK+ G      L +   Q +           L  V E E+R Q+LA  L+ LQ   
Sbjct: 788  RKATEKLLG-----SLDLDHTQYQFGHTKVFFKAGLLGVLE-ELRDQRLAKVLTLLQ--- 838

Query: 910  AATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQA 969
            A +   + RLE      G      +   ++   RA +    W      + F   +  L++
Sbjct: 839  ARSRGRLMRLEYQRLLGGRD----ALFTIQWNIRAFNAVKNW---SWMKLFFKMKPLLRS 891

Query: 970  MEREAE--QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
             + E E   +  EL  LR AL  ++ ++QE     E     +TQE+      L  E+   
Sbjct: 892  AQAEEELAALRAELRGLRGALAAAEAKRQE----LEETHVSITQEKNDLALQLQAEQDNL 947

Query: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA-KLRGLEAAQIKELEELRQT 1086
            A+ E R  + L + +V+     + L+  L ++E  + +LA + R LE     E  EL++ 
Sbjct: 948  ADAEERC-HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLE----DECTELKKD 1002

Query: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
            +  LK  LAK EKE  +    +++    TE    ++ AL   V++L ++ +  QE     
Sbjct: 1003 IDDLKLTLAKAEKEKQA---TENKVKNLTE----EMAALDESVARLTKEKKALQEAHQQA 1055

Query: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
               L+AE     +R SAL   + +LE++ ++L  S       + +    + K++   K  
Sbjct: 1056 LGDLQAEE----DRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLT 1111

Query: 1207 DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266
             E  A  A+ +Q+ E K   +   + E+S L+ +V +++    ++++ +     ++++LE
Sbjct: 1112 QESVADAAQDKQQLEEK---LKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168

Query: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLRE---------------EAEKQRVASE-- 1309
            E L   +A  A    + AE +  L E  + L E               EAE  R+  E  
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELE 1228

Query: 1310 --NLRQELT------SQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL 1361
               LR E T       QAE A ELG+++ + Q    + E+  S L++E     A V  L 
Sbjct: 1229 EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLT 1288

Query: 1362 PAKHLCQQL---QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAE 1418
             AK   ++L     +Q +  K   EEL++    A   R  L   Q E GEL  L +   E
Sbjct: 1289 RAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRL---QTESGELSRLLE---E 1342

Query: 1419 QERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQ 1478
            +E    QL   KA  A+ L  L++    L EE++     A+   Q L  + D  RE++ +
Sbjct: 1343 KECLISQLSRGKALAAQSLEELRRQ---LEEESKAKSALAH-AVQALRHDCDLLREQHEE 1398

Query: 1479 ELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1538
            E     A+A+   AE+QR       E+    +KYE   ++  EE    +E ++KL  +++
Sbjct: 1399 E-----AEAQ---AELQRLLSKANAEVAQWRSKYEADAIQRTEE---LEEAKKKLALRLQ 1447

Query: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
            + E       + VE  + K       S +++ KL+ +Q +  +   E +R  +    L  
Sbjct: 1448 EAE-------EGVEAANAK------CSSLEKAKLR-LQTESEDVTLELERATSAAAALDK 1493

Query: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQEL-----------QEQLRSLEQLQKENKE 1647
            +    E+A E  + Q E+ +   +A +++++ L           +E L +LE L++ENK 
Sbjct: 1494 KQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN 1553

Query: 1648 LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707
            L+ E   L  ++  +G   +E E+T + L  +   ++A +  A+  L      +  T  +
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE---LEETKTLRI 1610

Query: 1708 KSREPQAKPQLDLSIDSLDLSC 1729
            +    Q K ++D  +   D  C
Sbjct: 1611 QLELSQVKAEVDRKLAEKDEEC 1632



 Score =  127 bits (320), Expect = 9e-29
 Identities = 188/781 (24%), Positives = 343/781 (43%), Gaps = 120/781 (15%)

Query: 207  DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
            D L   + ++  L++QLAD  + R  L+ E  E  +LL EK+              L+++
Sbjct: 1303 DQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE-------------CLISQ 1349

Query: 267  KQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFK 326
                  L  + LEELR              +Q ++    KS +   +  L  +   L  +
Sbjct: 1350 LSRGKALAAQSLEELR--------------RQLEEESKAKSALAHAVQALRHDCDLLREQ 1395

Query: 327  LREFASHLQQLQDALN----ELTEEHSKATQEWLEKQAQLE---KELSAALQDKKCLEEK 379
              E A    +LQ  L+    E+ +  SK   + +++  +LE   K+L+  LQ+    EE 
Sbjct: 1396 HEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQE---AEEG 1452

Query: 380  NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML 439
             E    K S LE+   +LQ     E  +V    L+LE     AA L      L+  +E  
Sbjct: 1453 VEAANAKCSSLEKAKLRLQ----TESEDV---TLELERATSAAAALDKKQRHLERALE-- 1503

Query: 440  ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
              ER +QE ++  E    + E + L + +  L+       +A E L++ ++     L  +
Sbjct: 1504 --ERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENK----NLQEE 1557

Query: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE-QASQGLRHQVEQLSS 558
            ++ LT +++    +IQ+ ++    L+ +  E QA L +     E + ++ LR Q+E LS 
Sbjct: 1558 ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE-LSQ 1616

Query: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
               + +++L E  E+    R++H + + +     +A  R R+ AL+    L+K+    L 
Sbjct: 1617 VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR----LKKKMEGDLN 1672

Query: 619  ILQQQLQVANEARDSAQ--TSVTQAQREKAELSRKVEELQACV--ETARQEQHEAQAQVA 674
             L+ QL  A      AQ  T + QAQ ++ +  R  E+  A    E A+  +  A    A
Sbjct: 1673 DLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAA 1732

Query: 675  ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
            ELE +LR+  ++     R+A++  +L E  + L        G L ++K+  AD       
Sbjct: 1733 ELE-ELRAALEQGERSRRLAEQ--ELLEATERLNLLHSQNTGLLNQKKKLEAD------- 1782

Query: 735  CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
             +++L  E    VE+  +ER+E  EE+A +   +A +           E L++E  +  A
Sbjct: 1783 -LAQLSGE----VEEAAQERRE-AEEKAKKAITDAAMM---------AEELKKE-QDTSA 1826

Query: 795  AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
                 +   EQ V+E+ A   R E+++Q   + G                 ++++Q+ + 
Sbjct: 1827 HLERMKKTLEQTVRELQA---RLEEAEQAALRGG-----------------KKQVQKLEA 1866

Query: 855  KVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914
            KV  +E+    ++  +Q + AE       AL+ V++ E R ++LA      ++ +A    
Sbjct: 1867 KVRELEA----ELDAEQKKHAE-------ALKGVRKHERRVKELAYQAEEDRKNLARMQD 1915

Query: 915  EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQA-ALQAMERE 973
             V +L++ V+    Q E A ++     A+    Q E  + ++      TQA  L+A  R+
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975

Query: 974  A 974
            A
Sbjct: 1976 A 1976



 Score = 95.1 bits (235), Expect = 6e-19
 Identities = 139/638 (21%), Positives = 281/638 (44%), Gaps = 70/638 (10%)

Query: 167  ELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADE 226
            +L    H+ + E +  ELQ++ S ++    ++   +    D +Q  + ++   KK+LA  
Sbjct: 1390 DLLREQHEEEAEAQ-AELQRLLSKANAE--VAQWRSKYEADAIQRTE-ELEEAKKKLALR 1445

Query: 227  RSNRDELELELAENRKLLTEKDAQIAMMQQRID-RLALLNEKQAASPLEPKE------LE 279
                +E  +E A N K  + + A++ +  +  D  L L     AA+ L+ K+      LE
Sbjct: 1446 LQEAEE-GVEAA-NAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE 1503

Query: 280  ELRDKNESLTMRLHETLKQCQDLKTEKSQM--------------DRKINQLSEENGDLSF 325
            E R + E +   L    ++ + L TE  ++               R+   L EE  DL+ 
Sbjct: 1504 ERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD 1563

Query: 326  KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQG 385
            ++      +Q+L+     L  E S+      E +  LE E +  L+ +  L +    +  
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623

Query: 386  KLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ 445
            KL++ +E  + L+ N  Q   E L   L  ET         A N  L+ + +M E +   
Sbjct: 1624 KLAEKDEECANLRRN-HQRAVESLQASLDAET--------RARNEALRLKKKM-EGDLND 1673

Query: 446  QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ-ASQAH--GARLTAQVAS 502
             E +L    GH   +  +  +    +Q+ +      ++E ++ A++ H     L  + + 
Sbjct: 1674 LELQL----GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1729

Query: 503  LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
            L +EL  L A ++Q ++     ++ A+++  +  + L      + GL +Q ++L + L Q
Sbjct: 1730 LAAELEELRAALEQGERS----RRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQ 1785

Query: 563  KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
               +++E A+++    +   + +  AA   E   +E+D +   LE ++K     +  LQ 
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTS-AHLERMKKTLEQTVRELQA 1844

Query: 623  QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
            +L+ A +A      ++   +++  +L  KV EL+A ++  +++  EA   V + E   R 
Sbjct: 1845 RLEEAEQA------ALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHE---RR 1895

Query: 683  EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
             ++ A + E   +   ++Q+ +  L+  +K  K   EE +++A   L + ++   EL   
Sbjct: 1896 VKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHEL--- 1952

Query: 743  TRSLVEQHKRERKELEEERAGRKGLEARLQQ-LGEAHQ 779
                      ER ++ E +A +  L AR +  LG  H+
Sbjct: 1953 ------DDAEERADMAETQANK--LRARTRDALGPKHK 1982


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  207 bits (526), Expect = 1e-52
 Identities = 255/1169 (21%), Positives = 514/1169 (43%), Gaps = 171/1169 (14%)

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
            Q  R++ E+  K +ELQ      ++ Q +A+ ++ ELE     +  + TE++ + QE+ Q
Sbjct: 853  QVTRQEEEMQAKEDELQK----TKERQQKAENELKELE----QKHSQLTEEKNLLQEQLQ 904

Query: 700  LQEQLQALKESLKVT----KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
             + +L A  E ++V     K  LEE        LEE++    +L+AE + + +Q     +
Sbjct: 905  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 756  ELEEERAGRKGL-------EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
            +LEEE A R+ L       EA++++L +    E  V+  +  +    +   E     L  
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 809  EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
             +A   E+ ++  + + ++ +M  E  + LK+E EK+RQEL++ K K+ G  S    QI 
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI- 1078

Query: 869  RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
                  A+L A +A    Q+ +KE   ++L   L+ L +++A  +  + ++  L     +
Sbjct: 1079 ------ADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIRELEGHISD 1129

Query: 929  QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
             QE    E                           +AA    E++   +G ELE L+  L
Sbjct: 1130 LQEDLDSE---------------------------RAARNKAEKQKRDLGEELEALKTEL 1162

Query: 989  ---MESQGQQQEERGQQEREVA------------------RLTQERGRAQADLALE---- 1023
               ++S   QQE R ++E+EV                    + Q+  +A  +L  +    
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222

Query: 1024 KAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083
            K A+A L+   Q  L ++  + A     L  A  E E K ++L        AQ++EL+  
Sbjct: 1223 KRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLE-------AQVQELQSK 1274

Query: 1084 ----RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
                 +   +L +++ K + E  S +G  +EA G+       + +L +++   ++  Q++
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334

Query: 1140 --------------QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
                          +E+ +SL+  L+ E  ++   +  + TL  QL +  ++L    S +
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394

Query: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ---VL 1242
             + +     F+ ++++ ++  +E   + A   +  + KN L   L++ V  L+ Q   V 
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 1243 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
              E + ++  +L+  E   S K  +     +AE      +A   + AL E +++ +EE E
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELE 1510

Query: 1303 KQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA--LVSEL 1360
            +    ++ L+ E+       +++G+ +   ++     ++AL T Q+E   TQ   L  EL
Sbjct: 1511 R---TNKMLKAEMEDLVSSKDDVGKNVHELEKS----KRALET-QMEEMKTQLEELEDEL 1562

Query: 1361 LPAKHLCQQLQAEQAAAEKRHREEL----EQSKQAAGGLRAELLRAQRELGE------LI 1410
               +    +L+    A + +   +L    EQ+++    L+ +L   + EL +      L 
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 1411 PLRQKVAEQERTAQQLRAEKA--SYAEQLSMLKKAHGLLAEENRGLGE-RANLGRQFLEV 1467
               +K  E +    +L+A+ A     E +  L+K    + +  R L + RA+    F   
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
            +     EK  + L A     +  LA  +R  +    E E +  +   +    L  R   Q
Sbjct: 1683 K---ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS----LSGRNALQ 1735

Query: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
            +E+++L A++ QLE    E+   +E +S ++  + Q ++    +L   ++   +++   Q
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795

Query: 1588 RLQAQLNELQAQLSQKE-------------------QAAEHYKLQMEKAKTHYDAKKQQN 1628
            +L+ Q  EL+++L + E                   Q  E  + +  + +    + KQ++
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 1629 QELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
            ++L+E L  +E  +K  ++ + +AE+    ++Q   + +EAE+  + + A  R L+ ++ 
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 1689 HADQQLRDLGKFQVATDALKSREPQAKPQ 1717
             A +    +G+     +ALKS+     PQ
Sbjct: 1916 EATESNEAMGR---EVNALKSKLRGPPPQ 1941



 Score =  200 bits (509), Expect = 1e-50
 Identities = 257/1170 (21%), Positives = 510/1170 (43%), Gaps = 110/1170 (9%)

Query: 210  QTPQFQMRRLKKQLADERSNRDELELELAENR--KLLTEKDAQIAMMQQRIDRLALLNEK 267
            Q  + Q +  + Q   ER  + E EL+  E +  +L  EK+     +Q   +  A   E 
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 268  QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
            +     + +ELEE+  + E+   RL E   + Q L+ E+ +M +++  L E+       L
Sbjct: 917  RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQMLDLEEQ-------L 966

Query: 328  REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
             E  +  Q+LQ  L ++T E          K  +LE E+         ++++N  L  + 
Sbjct: 967  EEEEAARQKLQ--LEKVTAE---------AKIKKLEDEILV-------MDDQNNKLSKER 1008

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
              LEE +S L  N  +E+ +       L  LK +  ++ +     +  V + + E+ +QE
Sbjct: 1009 KLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMIS-----ELEVRLKKEEKSRQE 1059

Query: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507
             + L  +   E +       I DLQ+ I+ L     + E+  QA  ARL  ++A   + L
Sbjct: 1060 LEKLKRK--LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 508  TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
                  I++ +  ++ L++    ++A       + E+  + L  ++E L + L   E  L
Sbjct: 1118 ----KKIRELEGHISDLQEDLDSERA----ARNKAEKQKRDLGEELEALKTEL---EDTL 1166

Query: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
               A +QE  R    Q++    +  +   R  +A   Q++ + ++ A  +E L +QL+  
Sbjct: 1167 DSTATQQE-LRAKREQEVTVLKKALDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQF 1222

Query: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
              A+ +   +    ++E A+L+ ++  L    +    ++ + +AQV EL       Q K 
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-------QSKC 1275

Query: 688  TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
            ++ ER   E   L +++  L+  ++   G L E + +A            +L  +  SL 
Sbjct: 1276 SDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAI-----------KLAKDVASLS 1321

Query: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807
             Q +  ++ L+EE   +  +  +L+QL E    E   L+ +L E M A+   E     L 
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEE----ERNSLQDQLDEEMEAKQNLERHISTLN 1377

Query: 808  KEVAAWRERYED--SQQEEAQYG-AMFQEQLMTLKEECEK---ARQELQEAKEKVAGIES 861
             +++  +++ +D  S  E  + G   FQ+++  L ++ E+   A  +L++ K ++     
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
               + +  Q+  ++ L     +  Q + E++  + K AD+    + +      +   L  
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
             + +A E +E   R      A   D      ++  G+     + + +A+E + E+M  +L
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSS--KDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
            E L   L      Q  E  +   EV  +   +G+ + DL        E   +LQ  L+E 
Sbjct: 1556 EELEDEL------QATEDAKLRLEV-NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
              E    ++  A A   K+  + +L  L     + IK  EE  + +++L+ Q+   ++E 
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ---CQKQQEQADSLERSLEAERASRA 1158
                 ++ E     +    K ++L A++ +L++     ++ ++QAD  +  L  E AS  
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728

Query: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
               +AL+  + +LE +  +L   +  L   Q  + A   +V+  ++  ++   ++A  R 
Sbjct: 1729 SGRNALQDEKRRLEARIAQL---EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESK-ELKRLVMAESEKSQKLEERLRLLQAETA 1277
             A++  S    LE +   L  ++ E EG  K + K  + A   K  +LEE++     E  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 1278 SNSARAAERSSALRE---EVQSLREEAE--KQRVASENLR-QELTSQAERAEELGQELKA 1331
            + +    ++   L+E   +V+  R+ AE  K++    N R ++L  Q E AEE  Q + A
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 1332 WQEKFFQK-EQALSTLQLEHTSTQALVSEL 1360
             + K  ++ ++A  + +       AL S+L
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  188 bits (478), Expect = 4e-47
 Identities = 255/1172 (21%), Positives = 485/1172 (41%), Gaps = 145/1172 (12%)

Query: 495  RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
            RL  +V  L  ++T     +Q ++ EL    Q+ KE+Q +    L++ EQ    L  +  
Sbjct: 843  RLFTKVKPLL-QVTRQEEEMQAKEDEL----QKTKERQQKAENELKELEQKHSQLTEEKN 897

Query: 555  QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
             L   L Q E +L   AE+         Q+L     E EA L E +   +QL+A  K+ A
Sbjct: 898  LLQEQL-QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956

Query: 615  AKLEILQQQLQVANEARDSAQTS----------------VTQAQREKAELSRKV--EELQ 656
             ++  L++QL+    AR   Q                  V   Q  K    RK+  E + 
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016

Query: 657  ACVETARQEQHEA----------QAQVAELELQLRSEQQKATEKERVAQ----EKDQLQE 702
                   +E+ +A          ++ ++ELE++L+ E++   E E++ +    +     E
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076

Query: 703  Q---LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
            Q   LQA    LK+     EEE + A   L+++    +    + R L       +++L+ 
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY-E 818
            ERA R   E + + LGE    E E L+ EL + + +  T +    +  +EV   ++   E
Sbjct: 1137 ERAARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            +++  EAQ   M Q+    ++E  E    +L++ K   A ++ + +      + E A+L 
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTE----QLEQFKRAKANLDKNKQ----TLEKENADLA 1244

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L    Q  QE E + +KL   +  LQ K +   +  A L   V K   + E+ +  L 
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304

Query: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL---RAALMESQGQQ 995
            +   +A     +        Q   TQ  LQ   R+   +  +L +L   R +L +   ++
Sbjct: 1305 EAEGKAIKLAKD--VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362

Query: 996  QEERGQQEREVARLT---QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052
             E +   ER ++ L     +  +   D A    A  E + R Q  +     ++     A 
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
                  K    QEL  L       + +L+  RQ V  L+++  K ++  A      S+ A
Sbjct: 1423 DKLEKTKNRLQQELDDL-------VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
                           E  + E + ++++ +A SL R+LE    ++ E +   + L+ ++E
Sbjct: 1476 D--------------ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 1173 E----------KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE-----------WKA 1211
            +             EL  S+ AL +   E+     +++D  +A ++            K 
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR- 1270
            Q  R  Q  + +N      EE+   L RQ+ E E E ++ ++     +   +KLE  L+ 
Sbjct: 1582 QFERDLQARDEQN------EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 1271 -LLQAETA-SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
              LQA++A      A ++   L+ +++  + E E  R + + +        ++A+ L  +
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
            L   QE     E+A     LE             A+ L   L    A  +++ R E   +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEEL---------AEELASSLSGRNALQDEKRRLEARIA 1746

Query: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
            +     L  EL   + E G +  +  +V +  + A+QL  E A+        + A   L 
Sbjct: 1747 Q-----LEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798

Query: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
             +N+ L  + +      E+E    + K+   +AA+    E ++A+++ + +  ARE +  
Sbjct: 1799 RQNKELRSKLH------EME-GAVKSKFKSTIAAL----EAKIAQLEEQVEQEAREKQAA 1847

Query: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
            T   +    K+ E   + ++ER+      EQ E    +   +V++L ++L ++++ S+  
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE----KGNARVKQLKRQLEEAEEESQRI 1903

Query: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
                + +Q +  E+ +  + +  ++N L+++L
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  184 bits (468), Expect = 6e-46
 Identities = 243/1049 (23%), Positives = 442/1049 (42%), Gaps = 115/1049 (10%)

Query: 730  EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL 789
            EE Q    EL+ +T+   ++ + E KELE++ +    L      L E  QAETE L  E 
Sbjct: 859  EEMQAKEDELQ-KTKERQQKAENELKELEQKHSQ---LTEEKNLLQEQLQAETE-LYAEA 913

Query: 790  AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK---AR 846
             E        + E E+++ E+ A  E  ED  Q+         +Q++ L+E+ E+   AR
Sbjct: 914  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 847  QELQ----EAKEKVAGIESH------SELQISRQQNELAELHANLARALQQVQEKEVRAQ 896
            Q+LQ     A+ K+  +E           ++S+++  L E  ++L   L + +EK     
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 897  KLADD----LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
            KL +     +S L+ ++    K    LE L RK          ++    A+  + + +  
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 953  EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE 1012
            ++++       QAAL  ++ E  Q  N L+++R   +E      +E    ER      ++
Sbjct: 1094 KKEE-----ELQAALARLDDEIAQKNNALKKIRE--LEGHISDLQEDLDSERAARNKAEK 1146

Query: 1013 RGRAQADLALE-KAARAELEMRLQNALNEQRVEFATLQEA--LAHALTEKEGKDQELAKL 1069
            + R   DL  E +A + ELE  L +   +Q +     QE   L  AL E+    +  A++
Sbjct: 1147 QKR---DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE--AQV 1201

Query: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
            + +     + +EEL + ++Q K   A  +K   +     ++ AG     G   + +  + 
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261

Query: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
             KLE Q Q+ Q +    ER+       RAE +  +  LQ ++E     L  ++       
Sbjct: 1262 KKLEAQVQELQSKCSDGERA-------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1190 RELAAFRTKVQDHSKAEDEWKAQV----ARGRQEAERKNSLISSLEEEVSILNRQVLEKE 1245
            +++A+  +++QD  +   E   Q      + RQ  E +NSL   L+EE+           
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM----------- 1363

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
                          E  Q LE  +  L  + + +  +  + +S     V++L E  ++ +
Sbjct: 1364 --------------EAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQ 1405

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               ENL Q+   +A   ++L +     Q       Q L  L ++  + + LVS L   + 
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQ-------QELDDLVVDLDNQRQLVSNLEKKQR 1458

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
               QL AE+     ++ +E ++++  A     + L   R L E +  ++   E ERT + 
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKM 1515

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLG---ERANLGRQFLEVEL---DQAREKYVQE 1479
            L+AE          + K    L +  R L    E      + LE EL   + A+ +    
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            + A++   E  L     + +   R+L+    +YE       ++R      ++KL   ++ 
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ-------GGESQQEAQRLQAQ 1592
            LE+      K  EE  K+L       K  Q++L+  +A          E++++A+ L+A 
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648
            L +LQ  L+  E+A +   L+ E+      +       LQ++ R LE    QL++E +E 
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755

Query: 1649 RAEAERLGHELQQAGLKTKEAEQTCRHL-----TAQV-RSLEAQVAHADQQLRDLGKFQV 1702
            +   E +   +++A   T++AEQ    L     TAQ   S   Q+   +++LR   K   
Sbjct: 1756 QGNMEAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELR--SKLHE 1810

Query: 1703 ATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
               A+KS+       L+  I  L+   E+
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839



 Score =  146 bits (369), Expect = 2e-34
 Identities = 196/871 (22%), Positives = 361/871 (41%), Gaps = 110/871 (12%)

Query: 90   GSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLEN 149
            G ELE  K  +     ST + +  R   + E         +LK  LD E   +    ++ 
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQE-------VTVLKKALDEETRSH-EAQVQE 1203

Query: 150  FLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLE-----LQKVASSSSGNNFLSGSPASP 204
              QK        +   EEL+    Q KR    L+     L+K  +  +G   + G     
Sbjct: 1204 MRQK-------HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 205  MGDILQTPQFQMRRLKKQLADERSNRDELE----------------LELAENRKLLTEKD 248
            +    +  + Q++ L+ + +D    R EL                 L  AE + +   KD
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 249  AQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ 308
               ++  Q  D   LL E+         +L +L ++  SL  +L E ++  Q+L      
Sbjct: 1317 VA-SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL------ 1369

Query: 309  MDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA 368
             +R I+ L+ +  D   KL++FAS ++ L++      +E    TQ++ EK A  +K    
Sbjct: 1370 -ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---- 1424

Query: 369  ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428
                   LE+    LQ +L  L                     V+ L+  +Q    L +N
Sbjct: 1425 -------LEKTKNRLQQELDDL---------------------VVDLDNQRQ----LVSN 1452

Query: 429  NTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
              + Q + + L  E     +K   ER   E E ++  +    L  ++    +AKEELE+ 
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 489  SQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
            ++     L A++  L S    +   + + ++    L+ Q +E + QL + L+ + QA++ 
Sbjct: 1513 NK----MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATED 1567

Query: 549  LRHQVEQLSSSLK-QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLE 607
             + ++E    +LK Q E+ L+   E+ E  R+   +QL     E E   ++R  A     
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA----A 1623

Query: 608  ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667
            A +K+    L+ L+ Q   A + R+ A   + + Q +  +  R++E+ +A  +       
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 668  EAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR--- 724
            E + +   LE  L   Q+     ER  ++ D  +E+L     S    + +L++EKRR   
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743

Query: 725  ----AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780
                  + LEE+Q  +  +    R   +Q ++   EL  ER+  +  E+  QQL    + 
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL----ER 1799

Query: 781  ETEVLRRELAEAM-AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK 839
            + + LR +L E   A +   +S    L  ++A   E+ E   +E+       Q    +LK
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK-------QAATKSLK 1852

Query: 840  EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899
            ++ +K ++ L + +++    E + E Q  +    + +L   L  A ++ Q      +KL 
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911

Query: 900  DDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
             +L    E   A  +EV  L++ +R    Q+
Sbjct: 1912 RELDEATESNEAMGREVNALKSKLRGPPPQE 1942



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 123/561 (21%), Positives = 237/561 (42%), Gaps = 78/561 (13%)

Query: 70   KNRKHPSSPECLV---SAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAE 126
            KNR      + +V   + ++++   E +  K   LL     +SSK   + ++ E + + +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 127  LAVILKFVLDHEDGLNLNEDLE--NFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLEL 184
                L      E+ L   E+LE  N + KA +    SS   +++    H+ ++  R LE 
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALET 1546

Query: 185  QKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLL 244
            Q                             +M+   ++L DE    ++ +L L  N + L
Sbjct: 1547 QME---------------------------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1579

Query: 245  T---EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
                E+D Q    Q    R      +Q    L   E E L D+ +   +      K   D
Sbjct: 1580 KGQFERDLQARDEQNEEKR------RQLQRQLHEYETE-LEDERKQRALAAAAKKKLEGD 1632

Query: 302  LKTEKSQMDRKINQLSE---ENGDLSFKLREFASHLQQLQDALNEL---TEEHSKATQEW 355
            LK  + Q D  I    E   +   L  ++++F   L+  + + +E+    +E+ K  +  
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692

Query: 356  LEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
                 QL+++L+AA + +K  + + E L  +L+      + LQD    EK  +   + QL
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD----EKRRLEARIAQL 1748

Query: 416  -ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG---HFEEEKQQLSSLITDL 471
             E L++E   + A + +++   +  E    Q   +L  ER      E  +QQL     +L
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAE----QLSNELATERSTAQKNESARQQLERQNKEL 1804

Query: 472  QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
            +S +  +  A +          ++  + +A+L +++  L   ++Q+ +E     +  K+K
Sbjct: 1805 RSKLHEMEGAVK----------SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854

Query: 532  QAQLAQTLQQQE---QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE---ATRQDHAQQL 585
              +L + L Q E   + ++  + Q E+ ++ +KQ ++QL+E  E+ +   A R+   ++L
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 586  ATAAEEREASLRERDAALKQL 606
              A E  EA  RE +A   +L
Sbjct: 1915 DEATESNEAMGREVNALKSKL 1935



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 11/220 (5%)

Query: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
            KVK L +  R +EE Q    ++++ +  Q++   +++EL +K +   +   + Q++L+A 
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906

Query: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
                 E+++   RL A+  EL+  L + E   E  + + ++ +       QQ  +L+EQL
Sbjct: 907  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966

Query: 1636 RSLE----QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHAD 1691
               E    +LQ E     A+ ++L  E+     +  +  +  + L  ++  L   +A  +
Sbjct: 967  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 1692 QQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
            ++ ++L K       LK++      +L++ +   + S +E
Sbjct: 1027 EKAKNLTK-------LKNKHESMISELEVRLKKEEKSRQE 1059


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  207 bits (526), Expect = 1e-52
 Identities = 255/1169 (21%), Positives = 514/1169 (43%), Gaps = 171/1169 (14%)

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
            Q  R++ E+  K +ELQ      ++ Q +A+ ++ ELE     +  + TE++ + QE+ Q
Sbjct: 846  QVTRQEEEMQAKEDELQK----TKERQQKAENELKELE----QKHSQLTEEKNLLQEQLQ 897

Query: 700  LQEQLQALKESLKVT----KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
             + +L A  E ++V     K  LEE        LEE++    +L+AE + + +Q     +
Sbjct: 898  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 756  ELEEERAGRKGL-------EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
            +LEEE A R+ L       EA++++L +    E  V+  +  +    +   E     L  
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 809  EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
             +A   E+ ++  + + ++ +M  E  + LK+E EK+RQEL++ K K+ G  S    QI 
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI- 1071

Query: 869  RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
                  A+L A +A    Q+ +KE   ++L   L+ L +++A  +  + ++  L     +
Sbjct: 1072 ------ADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIRELEGHISD 1122

Query: 929  QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
             QE    E                           +AA    E++   +G ELE L+  L
Sbjct: 1123 LQEDLDSE---------------------------RAARNKAEKQKRDLGEELEALKTEL 1155

Query: 989  ---MESQGQQQEERGQQEREVA------------------RLTQERGRAQADLALE---- 1023
               ++S   QQE R ++E+EV                    + Q+  +A  +L  +    
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215

Query: 1024 KAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083
            K A+A L+   Q  L ++  + A     L  A  E E K ++L        AQ++EL+  
Sbjct: 1216 KRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLE-------AQVQELQSK 1267

Query: 1084 ----RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
                 +   +L +++ K + E  S +G  +EA G+       + +L +++   ++  Q++
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327

Query: 1140 --------------QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
                          +E+ +SL+  L+ E  ++   +  + TL  QL +  ++L    S +
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387

Query: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ---VL 1242
             + +     F+ ++++ ++  +E   + A   +  + KN L   L++ V  L+ Q   V 
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 1243 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
              E + ++  +L+  E   S K  +     +AE      +A   + AL E +++ +EE E
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELE 1503

Query: 1303 KQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA--LVSEL 1360
            +    ++ L+ E+       +++G+ +   ++     ++AL T Q+E   TQ   L  EL
Sbjct: 1504 R---TNKMLKAEMEDLVSSKDDVGKNVHELEKS----KRALET-QMEEMKTQLEELEDEL 1555

Query: 1361 LPAKHLCQQLQAEQAAAEKRHREEL----EQSKQAAGGLRAELLRAQRELGE------LI 1410
               +    +L+    A + +   +L    EQ+++    L+ +L   + EL +      L 
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615

Query: 1411 PLRQKVAEQERTAQQLRAEKA--SYAEQLSMLKKAHGLLAEENRGLGE-RANLGRQFLEV 1467
               +K  E +    +L+A+ A     E +  L+K    + +  R L + RA+    F   
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
            +     EK  + L A     +  LA  +R  +    E E +  +   +    L  R   Q
Sbjct: 1676 K---ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS----LSGRNALQ 1728

Query: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
            +E+++L A++ QLE    E+   +E +S ++  + Q ++    +L   ++   +++   Q
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788

Query: 1588 RLQAQLNELQAQLSQKE-------------------QAAEHYKLQMEKAKTHYDAKKQQN 1628
            +L+ Q  EL+++L + E                   Q  E  + +  + +    + KQ++
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 1629 QELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
            ++L+E L  +E  +K  ++ + +AE+    ++Q   + +EAE+  + + A  R L+ ++ 
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 1689 HADQQLRDLGKFQVATDALKSREPQAKPQ 1717
             A +    +G+     +ALKS+     PQ
Sbjct: 1909 EATESNEAMGR---EVNALKSKLRGPPPQ 1934



 Score =  200 bits (509), Expect = 1e-50
 Identities = 257/1170 (21%), Positives = 510/1170 (43%), Gaps = 110/1170 (9%)

Query: 210  QTPQFQMRRLKKQLADERSNRDELELELAENR--KLLTEKDAQIAMMQQRIDRLALLNEK 267
            Q  + Q +  + Q   ER  + E EL+  E +  +L  EK+     +Q   +  A   E 
Sbjct: 850  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 268  QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
            +     + +ELEE+  + E+   RL E   + Q L+ E+ +M +++  L E+       L
Sbjct: 910  RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQMLDLEEQ-------L 959

Query: 328  REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
             E  +  Q+LQ  L ++T E          K  +LE E+         ++++N  L  + 
Sbjct: 960  EEEEAARQKLQ--LEKVTAE---------AKIKKLEDEILV-------MDDQNNKLSKER 1001

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
              LEE +S L  N  +E+ +       L  LK +  ++ +     +  V + + E+ +QE
Sbjct: 1002 KLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMIS-----ELEVRLKKEEKSRQE 1052

Query: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507
             + L  +   E +       I DLQ+ I+ L     + E+  QA  ARL  ++A   + L
Sbjct: 1053 LEKLKRK--LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 508  TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
                  I++ +  ++ L++    ++A       + E+  + L  ++E L + L   E  L
Sbjct: 1111 ----KKIRELEGHISDLQEDLDSERA----ARNKAEKQKRDLGEELEALKTEL---EDTL 1159

Query: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
               A +QE  R    Q++    +  +   R  +A   Q++ + ++ A  +E L +QL+  
Sbjct: 1160 DSTATQQE-LRAKREQEVTVLKKALDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQF 1215

Query: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
              A+ +   +    ++E A+L+ ++  L    +    ++ + +AQV EL       Q K 
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-------QSKC 1268

Query: 688  TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
            ++ ER   E   L +++  L+  ++   G L E + +A            +L  +  SL 
Sbjct: 1269 SDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAI-----------KLAKDVASLS 1314

Query: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807
             Q +  ++ L+EE   +  +  +L+QL E    E   L+ +L E M A+   E     L 
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEE----ERNSLQDQLDEEMEAKQNLERHISTLN 1370

Query: 808  KEVAAWRERYED--SQQEEAQYG-AMFQEQLMTLKEECEK---ARQELQEAKEKVAGIES 861
             +++  +++ +D  S  E  + G   FQ+++  L ++ E+   A  +L++ K ++     
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
               + +  Q+  ++ L     +  Q + E++  + K AD+    + +      +   L  
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
             + +A E +E   R      A   D      ++  G+     + + +A+E + E+M  +L
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSS--KDDVGKNVHELEKSKRALETQMEEMKTQL 1548

Query: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
            E L   L      Q  E  +   EV  +   +G+ + DL        E   +LQ  L+E 
Sbjct: 1549 EELEDEL------QATEDAKLRLEV-NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
              E    ++  A A   K+  + +L  L     + IK  EE  + +++L+ Q+   ++E 
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ---CQKQQEQADSLERSLEAERASRA 1158
                 ++ E     +    K ++L A++ +L++     ++ ++QAD  +  L  E AS  
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721

Query: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
               +AL+  + +LE +  +L   +  L   Q  + A   +V+  ++  ++   ++A  R 
Sbjct: 1722 SGRNALQDEKRRLEARIAQL---EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESK-ELKRLVMAESEKSQKLEERLRLLQAETA 1277
             A++  S    LE +   L  ++ E EG  K + K  + A   K  +LEE++     E  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 1278 SNSARAAERSSALRE---EVQSLREEAE--KQRVASENLR-QELTSQAERAEELGQELKA 1331
            + +    ++   L+E   +V+  R+ AE  K++    N R ++L  Q E AEE  Q + A
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 1332 WQEKFFQK-EQALSTLQLEHTSTQALVSEL 1360
             + K  ++ ++A  + +       AL S+L
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  188 bits (478), Expect = 4e-47
 Identities = 255/1172 (21%), Positives = 485/1172 (41%), Gaps = 145/1172 (12%)

Query: 495  RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
            RL  +V  L  ++T     +Q ++ EL    Q+ KE+Q +    L++ EQ    L  +  
Sbjct: 836  RLFTKVKPLL-QVTRQEEEMQAKEDEL----QKTKERQQKAENELKELEQKHSQLTEEKN 890

Query: 555  QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
             L   L Q E +L   AE+         Q+L     E EA L E +   +QL+A  K+ A
Sbjct: 891  LLQEQL-QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949

Query: 615  AKLEILQQQLQVANEARDSAQTS----------------VTQAQREKAELSRKV--EELQ 656
             ++  L++QL+    AR   Q                  V   Q  K    RK+  E + 
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009

Query: 657  ACVETARQEQHEA----------QAQVAELELQLRSEQQKATEKERVAQ----EKDQLQE 702
                   +E+ +A          ++ ++ELE++L+ E++   E E++ +    +     E
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069

Query: 703  Q---LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
            Q   LQA    LK+     EEE + A   L+++    +    + R L       +++L+ 
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY-E 818
            ERA R   E + + LGE    E E L+ EL + + +  T +    +  +EV   ++   E
Sbjct: 1130 ERAARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            +++  EAQ   M Q+    ++E  E    +L++ K   A ++ + +      + E A+L 
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTE----QLEQFKRAKANLDKNKQ----TLEKENADLA 1237

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L    Q  QE E + +KL   +  LQ K +   +  A L   V K   + E+ +  L 
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297

Query: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL---RAALMESQGQQ 995
            +   +A     +        Q   TQ  LQ   R+   +  +L +L   R +L +   ++
Sbjct: 1298 EAEGKAIKLAKD--VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355

Query: 996  QEERGQQEREVARLT---QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052
             E +   ER ++ L     +  +   D A    A  E + R Q  +     ++     A 
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
                  K    QEL  L       + +L+  RQ V  L+++  K ++  A      S+ A
Sbjct: 1416 DKLEKTKNRLQQELDDL-------VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
                           E  + E + ++++ +A SL R+LE    ++ E +   + L+ ++E
Sbjct: 1469 D--------------ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 1173 E----------KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE-----------WKA 1211
            +             EL  S+ AL +   E+     +++D  +A ++            K 
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR- 1270
            Q  R  Q  + +N      EE+   L RQ+ E E E ++ ++     +   +KLE  L+ 
Sbjct: 1575 QFERDLQARDEQN------EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 1271 -LLQAETA-SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
              LQA++A      A ++   L+ +++  + E E  R + + +        ++A+ L  +
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
            L   QE     E+A     LE             A+ L   L    A  +++ R E   +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEEL---------AEELASSLSGRNALQDEKRRLEARIA 1739

Query: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
            +     L  EL   + E G +  +  +V +  + A+QL  E A+        + A   L 
Sbjct: 1740 Q-----LEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791

Query: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
             +N+ L  + +      E+E    + K+   +AA+    E ++A+++ + +  ARE +  
Sbjct: 1792 RQNKELRSKLH------EME-GAVKSKFKSTIAAL----EAKIAQLEEQVEQEAREKQAA 1840

Query: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
            T   +    K+ E   + ++ER+      EQ E    +   +V++L ++L ++++ S+  
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE----KGNARVKQLKRQLEEAEEESQRI 1896

Query: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
                + +Q +  E+ +  + +  ++N L+++L
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  184 bits (468), Expect = 6e-46
 Identities = 243/1049 (23%), Positives = 442/1049 (42%), Gaps = 115/1049 (10%)

Query: 730  EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL 789
            EE Q    EL+ +T+   ++ + E KELE++ +    L      L E  QAETE L  E 
Sbjct: 852  EEMQAKEDELQ-KTKERQQKAENELKELEQKHSQ---LTEEKNLLQEQLQAETE-LYAEA 906

Query: 790  AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK---AR 846
             E        + E E+++ E+ A  E  ED  Q+         +Q++ L+E+ E+   AR
Sbjct: 907  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 847  QELQ----EAKEKVAGIESH------SELQISRQQNELAELHANLARALQQVQEKEVRAQ 896
            Q+LQ     A+ K+  +E           ++S+++  L E  ++L   L + +EK     
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 897  KLADD----LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
            KL +     +S L+ ++    K    LE L RK          ++    A+  + + +  
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 953  EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE 1012
            ++++       QAAL  ++ E  Q  N L+++R   +E      +E    ER      ++
Sbjct: 1087 KKEE-----ELQAALARLDDEIAQKNNALKKIRE--LEGHISDLQEDLDSERAARNKAEK 1139

Query: 1013 RGRAQADLALE-KAARAELEMRLQNALNEQRVEFATLQEA--LAHALTEKEGKDQELAKL 1069
            + R   DL  E +A + ELE  L +   +Q +     QE   L  AL E+    +  A++
Sbjct: 1140 QKR---DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE--AQV 1194

Query: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
            + +     + +EEL + ++Q K   A  +K   +     ++ AG     G   + +  + 
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254

Query: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
             KLE Q Q+ Q +    ER+       RAE +  +  LQ ++E     L  ++       
Sbjct: 1255 KKLEAQVQELQSKCSDGERA-------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1190 RELAAFRTKVQDHSKAEDEWKAQV----ARGRQEAERKNSLISSLEEEVSILNRQVLEKE 1245
            +++A+  +++QD  +   E   Q      + RQ  E +NSL   L+EE+           
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM----------- 1356

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
                          E  Q LE  +  L  + + +  +  + +S     V++L E  ++ +
Sbjct: 1357 --------------EAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQ 1398

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               ENL Q+   +A   ++L +     Q       Q L  L ++  + + LVS L   + 
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQ-------QELDDLVVDLDNQRQLVSNLEKKQR 1451

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
               QL AE+     ++ +E ++++  A     + L   R L E +  ++   E ERT + 
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKM 1508

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLG---ERANLGRQFLEVEL---DQAREKYVQE 1479
            L+AE          + K    L +  R L    E      + LE EL   + A+ +    
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            + A++   E  L     + +   R+L+    +YE       ++R      ++KL   ++ 
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ-------GGESQQEAQRLQAQ 1592
            LE+      K  EE  K+L       K  Q++L+  +A          E++++A+ L+A 
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648
            L +LQ  L+  E+A +   L+ E+      +       LQ++ R LE    QL++E +E 
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748

Query: 1649 RAEAERLGHELQQAGLKTKEAEQTCRHL-----TAQV-RSLEAQVAHADQQLRDLGKFQV 1702
            +   E +   +++A   T++AEQ    L     TAQ   S   Q+   +++LR   K   
Sbjct: 1749 QGNMEAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELR--SKLHE 1803

Query: 1703 ATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
               A+KS+       L+  I  L+   E+
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832



 Score =  146 bits (369), Expect = 2e-34
 Identities = 196/871 (22%), Positives = 361/871 (41%), Gaps = 110/871 (12%)

Query: 90   GSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLEN 149
            G ELE  K  +     ST + +  R   + E         +LK  LD E   +    ++ 
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQE-------VTVLKKALDEETRSH-EAQVQE 1196

Query: 150  FLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLE-----LQKVASSSSGNNFLSGSPASP 204
              QK        +   EEL+    Q KR    L+     L+K  +  +G   + G     
Sbjct: 1197 MRQK-------HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 205  MGDILQTPQFQMRRLKKQLADERSNRDELE----------------LELAENRKLLTEKD 248
            +    +  + Q++ L+ + +D    R EL                 L  AE + +   KD
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 249  AQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ 308
               ++  Q  D   LL E+         +L +L ++  SL  +L E ++  Q+L      
Sbjct: 1310 VA-SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL------ 1362

Query: 309  MDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA 368
             +R I+ L+ +  D   KL++FAS ++ L++      +E    TQ++ EK A  +K    
Sbjct: 1363 -ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---- 1417

Query: 369  ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428
                   LE+    LQ +L  L                     V+ L+  +Q    L +N
Sbjct: 1418 -------LEKTKNRLQQELDDL---------------------VVDLDNQRQ----LVSN 1445

Query: 429  NTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
              + Q + + L  E     +K   ER   E E ++  +    L  ++    +AKEELE+ 
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 489  SQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
            ++     L A++  L S    +   + + ++    L+ Q +E + QL + L+ + QA++ 
Sbjct: 1506 NK----MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATED 1560

Query: 549  LRHQVEQLSSSLK-QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLE 607
             + ++E    +LK Q E+ L+   E+ E  R+   +QL     E E   ++R  A     
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA----A 1616

Query: 608  ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667
            A +K+    L+ L+ Q   A + R+ A   + + Q +  +  R++E+ +A  +       
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 668  EAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR--- 724
            E + +   LE  L   Q+     ER  ++ D  +E+L     S    + +L++EKRR   
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736

Query: 725  ----AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780
                  + LEE+Q  +  +    R   +Q ++   EL  ER+  +  E+  QQL    + 
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL----ER 1792

Query: 781  ETEVLRRELAEAM-AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK 839
            + + LR +L E   A +   +S    L  ++A   E+ E   +E+       Q    +LK
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK-------QAATKSLK 1845

Query: 840  EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899
            ++ +K ++ L + +++    E + E Q  +    + +L   L  A ++ Q      +KL 
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904

Query: 900  DDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
             +L    E   A  +EV  L++ +R    Q+
Sbjct: 1905 RELDEATESNEAMGREVNALKSKLRGPPPQE 1935



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 123/561 (21%), Positives = 237/561 (42%), Gaps = 78/561 (13%)

Query: 70   KNRKHPSSPECLV---SAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAE 126
            KNR      + +V   + ++++   E +  K   LL     +SSK   + ++ E + + +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 127  LAVILKFVLDHEDGLNLNEDLE--NFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLEL 184
                L      E+ L   E+LE  N + KA +    SS   +++    H+ ++  R LE 
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALET 1539

Query: 185  QKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLL 244
            Q                             +M+   ++L DE    ++ +L L  N + L
Sbjct: 1540 QME---------------------------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1572

Query: 245  T---EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
                E+D Q    Q    R      +Q    L   E E L D+ +   +      K   D
Sbjct: 1573 KGQFERDLQARDEQNEEKR------RQLQRQLHEYETE-LEDERKQRALAAAAKKKLEGD 1625

Query: 302  LKTEKSQMDRKINQLSE---ENGDLSFKLREFASHLQQLQDALNEL---TEEHSKATQEW 355
            LK  + Q D  I    E   +   L  ++++F   L+  + + +E+    +E+ K  +  
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685

Query: 356  LEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
                 QL+++L+AA + +K  + + E L  +L+      + LQD    EK  +   + QL
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD----EKRRLEARIAQL 1741

Query: 416  -ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG---HFEEEKQQLSSLITDL 471
             E L++E   + A + +++   +  E    Q   +L  ER      E  +QQL     +L
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAE----QLSNELATERSTAQKNESARQQLERQNKEL 1797

Query: 472  QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
            +S +  +  A +          ++  + +A+L +++  L   ++Q+ +E     +  K+K
Sbjct: 1798 RSKLHEMEGAVK----------SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847

Query: 532  QAQLAQTLQQQE---QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE---ATRQDHAQQL 585
              +L + L Q E   + ++  + Q E+ ++ +KQ ++QL+E  E+ +   A R+   ++L
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 586  ATAAEEREASLRERDAALKQL 606
              A E  EA  RE +A   +L
Sbjct: 1908 DEATESNEAMGREVNALKSKL 1928



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 11/220 (5%)

Query: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
            KVK L +  R +EE Q    ++++ +  Q++   +++EL +K +   +   + Q++L+A 
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899

Query: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
                 E+++   RL A+  EL+  L + E   E  + + ++ +       QQ  +L+EQL
Sbjct: 900  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959

Query: 1636 RSLE----QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHAD 1691
               E    +LQ E     A+ ++L  E+     +  +  +  + L  ++  L   +A  +
Sbjct: 960  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 1692 QQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
            ++ ++L K       LK++      +L++ +   + S +E
Sbjct: 1020 EKAKNLTK-------LKNKHESMISELEVRLKKEEKSRQE 1052


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  206 bits (523), Expect = 3e-52
 Identities = 253/1162 (21%), Positives = 512/1162 (44%), Gaps = 171/1162 (14%)

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
            Q  R++ E+  K +ELQ      ++ Q +A+ ++ ELE     +  + TE++ + QE+ Q
Sbjct: 846  QVTRQEEEMQAKEDELQK----TKERQQKAENELKELE----QKHSQLTEEKNLLQEQLQ 897

Query: 700  LQEQLQALKESLKVT----KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
             + +L A  E ++V     K  LEE        LEE++    +L+AE + + +Q     +
Sbjct: 898  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 756  ELEEERAGRKGL-------EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
            +LEEE A R+ L       EA++++L +    E  V+  +  +    +   E     L  
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 809  EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
             +A   E+ ++  + + ++ +M  E  + LK+E EK+RQEL++ K K+ G  S    QI 
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI- 1071

Query: 869  RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
                  A+L A +A    Q+ +KE   ++L   L+ L +++A  +  + ++  L     +
Sbjct: 1072 ------ADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIRELEGHISD 1122

Query: 929  QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
             QE    E                           +AA    E++   +G ELE L+  L
Sbjct: 1123 LQEDLDSE---------------------------RAARNKAEKQKRDLGEELEALKTEL 1155

Query: 989  ---MESQGQQQEERGQQEREVA------------------RLTQERGRAQADLALE---- 1023
               ++S   QQE R ++E+EV                    + Q+  +A  +L  +    
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215

Query: 1024 KAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083
            K A+A L+   Q  L ++  + A     L  A  E E K ++L        AQ++EL+  
Sbjct: 1216 KRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLE-------AQVQELQSK 1267

Query: 1084 ----RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
                 +   +L +++ K + E  S +G  +EA G+       + +L +++   ++  Q++
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327

Query: 1140 --------------QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
                          +E+ +SL+  L+ E  ++   +  + TL  QL +  ++L    S +
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387

Query: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ---VL 1242
             + +     F+ ++++ ++  +E   + A   +  + KN L   L++ V  L+ Q   V 
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 1243 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
              E + ++  +L+  E   S K  +     +AE      +A   + AL E +++ +EE E
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELE 1503

Query: 1303 KQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA--LVSEL 1360
            +    ++ L+ E+       +++G+ +   ++     ++AL T Q+E   TQ   L  EL
Sbjct: 1504 R---TNKMLKAEMEDLVSSKDDVGKNVHELEKS----KRALET-QMEEMKTQLEELEDEL 1555

Query: 1361 LPAKHLCQQLQAEQAAAEKRHREEL----EQSKQAAGGLRAELLRAQRELGE------LI 1410
               +    +L+    A + +   +L    EQ+++    L+ +L   + EL +      L 
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615

Query: 1411 PLRQKVAEQERTAQQLRAEKA--SYAEQLSMLKKAHGLLAEENRGLGE-RANLGRQFLEV 1467
               +K  E +    +L+A+ A     E +  L+K    + +  R L + RA+    F   
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
            +     EK  + L A     +  LA  +R  +    E E +  +   +    L  R   Q
Sbjct: 1676 K---ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS----LSGRNALQ 1728

Query: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
            +E+++L A++ QLE    E+   +E +S ++  + Q ++    +L   ++   +++   Q
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788

Query: 1588 RLQAQLNELQAQLSQKE-------------------QAAEHYKLQMEKAKTHYDAKKQQN 1628
            +L+ Q  EL+++L + E                   Q  E  + +  + +    + KQ++
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 1629 QELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
            ++L+E L  +E  +K  ++ + +AE+    ++Q   + +EAE+  + + A  R L+ ++ 
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 1689 HADQQLRDLGKFQVATDALKSR 1710
             A +    +G+     +ALKS+
Sbjct: 1909 EATESNEAMGR---EVNALKSK 1927



 Score =  200 bits (509), Expect = 1e-50
 Identities = 257/1170 (21%), Positives = 510/1170 (43%), Gaps = 110/1170 (9%)

Query: 210  QTPQFQMRRLKKQLADERSNRDELELELAENR--KLLTEKDAQIAMMQQRIDRLALLNEK 267
            Q  + Q +  + Q   ER  + E EL+  E +  +L  EK+     +Q   +  A   E 
Sbjct: 850  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909

Query: 268  QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
            +     + +ELEE+  + E+   RL E   + Q L+ E+ +M +++  L E+       L
Sbjct: 910  RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQMLDLEEQ-------L 959

Query: 328  REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
             E  +  Q+LQ  L ++T E          K  +LE E+         ++++N  L  + 
Sbjct: 960  EEEEAARQKLQ--LEKVTAE---------AKIKKLEDEILV-------MDDQNNKLSKER 1001

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
              LEE +S L  N  +E+ +       L  LK +  ++ +     +  V + + E+ +QE
Sbjct: 1002 KLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMIS-----ELEVRLKKEEKSRQE 1052

Query: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507
             + L  +   E +       I DLQ+ I+ L     + E+  QA  ARL  ++A   + L
Sbjct: 1053 LEKLKRK--LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 508  TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
                  I++ +  ++ L++    ++A       + E+  + L  ++E L + L   E  L
Sbjct: 1111 ----KKIRELEGHISDLQEDLDSERA----ARNKAEKQKRDLGEELEALKTEL---EDTL 1159

Query: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
               A +QE  R    Q++    +  +   R  +A   Q++ + ++ A  +E L +QL+  
Sbjct: 1160 DSTATQQE-LRAKREQEVTVLKKALDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQF 1215

Query: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
              A+ +   +    ++E A+L+ ++  L    +    ++ + +AQV EL       Q K 
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-------QSKC 1268

Query: 688  TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
            ++ ER   E   L +++  L+  ++   G L E + +A            +L  +  SL 
Sbjct: 1269 SDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAI-----------KLAKDVASLS 1314

Query: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807
             Q +  ++ L+EE   +  +  +L+QL E    E   L+ +L E M A+   E     L 
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEE----ERNSLQDQLDEEMEAKQNLERHISTLN 1370

Query: 808  KEVAAWRERYED--SQQEEAQYG-AMFQEQLMTLKEECEK---ARQELQEAKEKVAGIES 861
             +++  +++ +D  S  E  + G   FQ+++  L ++ E+   A  +L++ K ++     
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
               + +  Q+  ++ L     +  Q + E++  + K AD+    + +      +   L  
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
             + +A E +E   R      A   D      ++  G+     + + +A+E + E+M  +L
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSS--KDDVGKNVHELEKSKRALETQMEEMKTQL 1548

Query: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
            E L   L      Q  E  +   EV  +   +G+ + DL        E   +LQ  L+E 
Sbjct: 1549 EELEDEL------QATEDAKLRLEV-NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
              E    ++  A A   K+  + +L  L     + IK  EE  + +++L+ Q+   ++E 
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ---CQKQQEQADSLERSLEAERASRA 1158
                 ++ E     +    K ++L A++ +L++     ++ ++QAD  +  L  E AS  
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721

Query: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
               +AL+  + +LE +  +L   +  L   Q  + A   +V+  ++  ++   ++A  R 
Sbjct: 1722 SGRNALQDEKRRLEARIAQL---EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESK-ELKRLVMAESEKSQKLEERLRLLQAETA 1277
             A++  S    LE +   L  ++ E EG  K + K  + A   K  +LEE++     E  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 1278 SNSARAAERSSALRE---EVQSLREEAE--KQRVASENLR-QELTSQAERAEELGQELKA 1331
            + +    ++   L+E   +V+  R+ AE  K++    N R ++L  Q E AEE  Q + A
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 1332 WQEKFFQK-EQALSTLQLEHTSTQALVSEL 1360
             + K  ++ ++A  + +       AL S+L
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  194 bits (492), Expect = 1e-48
 Identities = 255/1113 (22%), Positives = 476/1113 (42%), Gaps = 109/1113 (9%)

Query: 242  KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
            K L +   Q   MQ + D L    E+Q  +  E KELE+   +       L E L+   +
Sbjct: 842  KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 302  LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
            L  E  +M  ++    +E  ++   L E  + L++ +D   +L  E  K  Q+ L+ + Q
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 362  LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQD--NPPQEKGEVLGD-VLQLETL 418
            LE+E +A    ++ L+ +    + K+ +LE+ +  + D  N   ++ ++L + +  L T 
Sbjct: 959  LEEEEAA----RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 419  KQEAATLAANNTQLQAR---------VEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
              E    A N T+L+ +         V + + E+ +QE + L  +   E +       I 
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIA 1072

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLN------ATIQQQ-DQELA 522
            DLQ+ I+ L     + E+  QA  ARL  ++A   + L  +       + +Q+  D E A
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132

Query: 523  GLKQQAKEKQ----------AQLAQTLQQQEQASQGLRHQVEQLSSSLKQK--EQQLKEV 570
               +  K+K+           +L  TL       Q LR + EQ  + LK+   E+     
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTA-TQQELRAKREQEVTVLKKALDEETRSHE 1191

Query: 571  AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA---AKLEILQQQLQVA 627
            A+ QE  RQ HAQ +    E+ E   R +    K  + LEKE A    +L +L Q  Q  
Sbjct: 1192 AQVQEM-RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250

Query: 628  NEARDSAQTSVTQAQ-------REKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               +   +  V + Q       R +AEL+ KV +LQ  VE+     +EA+ +  +L   +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
             S   +  + + + QE     E  Q L  S K+ +  LEEE+    D L+E+      L+
Sbjct: 1311 ASLSSQLQDTQELLQE-----ETRQKLNVSTKLRQ--LEEERNSLQDQLDEEMEAKQNLE 1363

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA----- 795
                +L  Q    +K+L++  +  + LE   ++     Q E E L ++  E  AA     
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF----QKEIENLTQQYEEKAAAYDKLE 1419

Query: 796  --QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
              ++  + E + LV ++   R+   + ++++ ++  +  E+     +  ++  +   EA+
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479

Query: 854  EKVA-----------GIESHSELQ-----ISRQQNELAELHANLARALQQVQEK----EV 893
            EK              +E+  EL+     +  +  +L     ++ + + ++++     E 
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 894  RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQET---ASRELVKEPARAGDRQPE 950
            + +++   L  L++++ AT     RLE  ++    Q E    A  E  +E  R   RQ  
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 951  WLE---EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVA 1007
              E   E + +Q     AA + +E + + +  EL+   A     +  +Q  + Q + +  
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQLRKLQAQMKDF 1657

Query: 1008 RLTQERGRAQADLALEKAARAELEMR-LQNALNEQRVEFATLQEALAHALTEKEGKDQEL 1066
            +   E  RA  D     A   E + + L+  L + + + A  + A   A  EKE   +EL
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717

Query: 1067 AK-LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
            A  L G  A Q  E   L   + QL+E+L +++    + S    +A  + E    +L   
Sbjct: 1718 ASSLSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776

Query: 1126 RAEVSKLE---QQCQKQQEQADSLERSLEAERASR-----AERDSALETLQGQLEEKAQE 1177
            R+   K E   QQ ++Q ++  S    +E    S+     A  ++ +  L+ Q+E++A+E
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836

Query: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
               +  +L    ++L     +V+D  K  +++K Q  +G    ++    +   EEE   +
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896

Query: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
            N    + + E  E      A   +   L+ +LR
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score =  189 bits (479), Expect = 3e-47
 Identities = 255/1179 (21%), Positives = 488/1179 (41%), Gaps = 145/1179 (12%)

Query: 495  RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
            RL  +V  L  ++T     +Q ++ EL    Q+ KE+Q +    L++ EQ    L  +  
Sbjct: 836  RLFTKVKPLL-QVTRQEEEMQAKEDEL----QKTKERQQKAENELKELEQKHSQLTEEKN 890

Query: 555  QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
             L   L Q E +L   AE+         Q+L     E EA L E +   +QL+A  K+ A
Sbjct: 891  LLQEQL-QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949

Query: 615  AKLEILQQQLQVANEARDSAQTS----------------VTQAQREKAELSRKV--EELQ 656
             ++  L++QL+    AR   Q                  V   Q  K    RK+  E + 
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009

Query: 657  ACVETARQEQHEA----------QAQVAELELQLRSEQQKATEKERVAQ----EKDQLQE 702
                   +E+ +A          ++ ++ELE++L+ E++   E E++ +    +     E
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069

Query: 703  Q---LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
            Q   LQA    LK+     EEE + A   L+++    +    + R L       +++L+ 
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY-E 818
            ERA R   E + + LGE    E E L+ EL + + +  T +    +  +EV   ++   E
Sbjct: 1130 ERAARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            +++  EAQ   M Q+    ++E  E    +L++ K   A ++ + +      + E A+L 
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTE----QLEQFKRAKANLDKNKQ----TLEKENADLA 1237

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L    Q  QE E + +KL   +  LQ K +   +  A L   V K   + E+ +  L 
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297

Query: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL---RAALMESQGQQ 995
            +   +A     +        Q   TQ  LQ   R+   +  +L +L   R +L +   ++
Sbjct: 1298 EAEGKAIKLAKD--VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355

Query: 996  QEERGQQEREVARLT---QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052
             E +   ER ++ L     +  +   D A    A  E + R Q  +     ++     A 
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
                  K    QEL  L       + +L+  RQ V  L+++  K ++  A      S+ A
Sbjct: 1416 DKLEKTKNRLQQELDDL-------VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
                           E  + E + ++++ +A SL R+LE    ++ E +   + L+ ++E
Sbjct: 1469 D--------------ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 1173 E----------KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE-----------WKA 1211
            +             EL  S+ AL +   E+     +++D  +A ++            K 
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR- 1270
            Q  R  Q  + +N      EE+   L RQ+ E E E ++ ++     +   +KLE  L+ 
Sbjct: 1575 QFERDLQARDEQN------EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 1271 -LLQAETA-SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
              LQA++A      A ++   L+ +++  + E E  R + + +        ++A+ L  +
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
            L   QE     E+A     LE             A+ L   L    A  +++ R E   +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEEL---------AEELASSLSGRNALQDEKRRLEARIA 1739

Query: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
            +     L  EL   + E G +  +  +V +  + A+QL  E A+        + A   L 
Sbjct: 1740 Q-----LEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791

Query: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
             +N+ L  + +      E+E    + K+   +AA+    E ++A+++ + +  ARE +  
Sbjct: 1792 RQNKELRSKLH------EME-GAVKSKFKSTIAAL----EAKIAQLEEQVEQEAREKQAA 1840

Query: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
            T   +    K+ E   + ++ER+      EQ E    +   +V++L ++L ++++ S+  
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE----KGNARVKQLKRQLEEAEEESQRI 1896

Query: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
                + +Q +  E+ +  + +  ++N L+++L +  + +
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935



 Score =  184 bits (468), Expect = 6e-46
 Identities = 243/1049 (23%), Positives = 442/1049 (42%), Gaps = 115/1049 (10%)

Query: 730  EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL 789
            EE Q    EL+ +T+   ++ + E KELE++ +    L      L E  QAETE L  E 
Sbjct: 852  EEMQAKEDELQ-KTKERQQKAENELKELEQKHSQ---LTEEKNLLQEQLQAETE-LYAEA 906

Query: 790  AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK---AR 846
             E        + E E+++ E+ A  E  ED  Q+         +Q++ L+E+ E+   AR
Sbjct: 907  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 847  QELQ----EAKEKVAGIESH------SELQISRQQNELAELHANLARALQQVQEKEVRAQ 896
            Q+LQ     A+ K+  +E           ++S+++  L E  ++L   L + +EK     
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 897  KLADD----LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
            KL +     +S L+ ++    K    LE L RK          ++    A+  + + +  
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 953  EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE 1012
            ++++       QAAL  ++ E  Q  N L+++R   +E      +E    ER      ++
Sbjct: 1087 KKEE-----ELQAALARLDDEIAQKNNALKKIRE--LEGHISDLQEDLDSERAARNKAEK 1139

Query: 1013 RGRAQADLALE-KAARAELEMRLQNALNEQRVEFATLQEA--LAHALTEKEGKDQELAKL 1069
            + R   DL  E +A + ELE  L +   +Q +     QE   L  AL E+    +  A++
Sbjct: 1140 QKR---DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE--AQV 1194

Query: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
            + +     + +EEL + ++Q K   A  +K   +     ++ AG     G   + +  + 
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254

Query: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
             KLE Q Q+ Q +    ER+       RAE +  +  LQ ++E     L  ++       
Sbjct: 1255 KKLEAQVQELQSKCSDGERA-------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1190 RELAAFRTKVQDHSKAEDEWKAQV----ARGRQEAERKNSLISSLEEEVSILNRQVLEKE 1245
            +++A+  +++QD  +   E   Q      + RQ  E +NSL   L+EE+           
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM----------- 1356

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
                          E  Q LE  +  L  + + +  +  + +S     V++L E  ++ +
Sbjct: 1357 --------------EAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQ 1398

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               ENL Q+   +A   ++L +     Q       Q L  L ++  + + LVS L   + 
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQ-------QELDDLVVDLDNQRQLVSNLEKKQR 1451

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
               QL AE+     ++ +E ++++  A     + L   R L E +  ++   E ERT + 
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKM 1508

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLG---ERANLGRQFLEVEL---DQAREKYVQE 1479
            L+AE          + K    L +  R L    E      + LE EL   + A+ +    
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            + A++   E  L     + +   R+L+    +YE       ++R      ++KL   ++ 
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ-------GGESQQEAQRLQAQ 1592
            LE+      K  EE  K+L       K  Q++L+  +A          E++++A+ L+A 
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648
            L +LQ  L+  E+A +   L+ E+      +       LQ++ R LE    QL++E +E 
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748

Query: 1649 RAEAERLGHELQQAGLKTKEAEQTCRHL-----TAQV-RSLEAQVAHADQQLRDLGKFQV 1702
            +   E +   +++A   T++AEQ    L     TAQ   S   Q+   +++LR   K   
Sbjct: 1749 QGNMEAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELR--SKLHE 1803

Query: 1703 ATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
               A+KS+       L+  I  L+   E+
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832



 Score =  166 bits (421), Expect = 2e-40
 Identities = 222/1004 (22%), Positives = 431/1004 (42%), Gaps = 116/1004 (11%)

Query: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA----LLNEK--- 267
            QM  L++QL +E + R +L+LE       + + + +I +M  + ++L+    LL E+   
Sbjct: 951  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 268  ----QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI----NQLSEE 319
                 A    + K L +L++K+ES+   L   LK+ +  + E  ++ RK+    +   E+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 320  NGDLSFKLREFASHL----QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD--- 372
              DL  ++ E    L    ++LQ AL  L +E ++     L+K  +LE  +S   +D   
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA-LKKIRELEGHISDLQEDLDS 1129

Query: 373  -----------KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV--LGDVLQLETLK 419
                       K+ L E+ E L+ +L    +  +  Q+   + + EV  L   L  ET  
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 420  QEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLS 479
             EA          QA  E+ E     + AK      + ++ KQ L     DL   +  L 
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAK-----ANLDKNKQTLEKENADLAGELRVLG 1244

Query: 480  QAKEELEQASQAHGARLTAQVASLTS----------ELTTLNATIQQQDQELAGLKQQAK 529
            QAK+E+E   +    +L AQV  L S          EL      +Q + + + G+  +A+
Sbjct: 1245 QAKQEVEHKKK----KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 530  EKQAQLAQT-------LQQQEQASQGLRHQVEQLSSSLKQKEQQLK----EVAEKQEATR 578
             K  +LA+        LQ  ++  Q    Q   +S+ L+Q E++      ++ E+ EA +
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360

Query: 579  --QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
              + H   L     + +  L++  + ++ LE  +K    ++E L QQ +    A D  + 
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 637  SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE--------QQKAT 688
            +  + Q+E  +L   ++  +  V    ++Q +    +AE E  + S+        + +A 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 1479

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL-- 746
            EKE  A    +  E+    KE L+ T   L+ E      + ++  + + EL+   R+L  
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 747  -VEQHKRERKELEEERAGRKG----LEARLQQLG-------EAHQAETEVLRRELAEAMA 794
             +E+ K + +ELE+E    +     LE  +Q L        +A   + E  RR+L   + 
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 795  AQHTA-ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ------EQLMTLKEECEKARQ 847
               T  E E +Q     AA ++   D +  E Q  +  +      +QL  L+ + +  ++
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 848  ELQEAK---EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLST 904
            EL++A+   +++      +E +    + +L +L  +LA A +  ++ ++  ++LA++L++
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 905  LQEKMAATSKEVARLETLVRKAGEQ--QETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962
                  A   E  RLE  + +  E+  +E  + E + +  R   +Q E L  +   +  +
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779

Query: 963  TQ---AALQAMEREAEQMGNELERLRAAL----------MESQGQQQEERGQQEREVARL 1009
             Q   +A Q +ER+ +++ ++L  +  A+          +E++  Q EE+ +QE    + 
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 1010 TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069
              +  + +     E   + E E ++     EQ  +     + L   L E E + Q +   
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899

Query: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
            R     ++ E  E  + + +    L  K +     S   S  +G
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1943



 Score =  112 bits (280), Expect = 4e-24
 Identities = 134/583 (22%), Positives = 261/583 (44%), Gaps = 67/583 (11%)

Query: 218  RLKKQLAD---ERSNRDELELELAENRK-----LLTEKDAQIAMMQQRIDRLALLNEKQA 269
            RL+++L D   +  N+ +L   L + ++     L  EK+       +R    A   EK+ 
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 270  ASPLEPKELEELRDKNESLTMRLHETLK-QCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             +    + LEE  +  E L  R ++ LK + +DL + K  + + +++L +    L  ++ 
Sbjct: 1484 KALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS 388
            E  + L++L+D L    +   +        + Q E++L A  +     EEK   LQ    
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---EEKRRQLQ---R 1596

Query: 389  QLEEHLSQLQDNPPQE------KGEVLGDVLQLETLKQEAATLAANNTQLQAR---VEML 439
            QL E+ ++L+D   Q       K ++ GD+  LE L+ ++A         Q R    +M 
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-LQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 440  ETERGQQEAKLLAER--GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
            + +R  ++A+   +      +E +++  SL  DL     +L+ A+   +QA       L 
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD-LEKEELA 1714

Query: 498  AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
             ++AS  S    L    ++ +  +A L+++ +E+Q  +     +  +A+Q    Q EQLS
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ----QAEQLS 1770

Query: 558  SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ-----LEALEKE 612
            + L  +    +  A+K E+ RQ    QL    +E  + L E + A+K      + ALE  
Sbjct: 1771 NELATE----RSTAQKNESARQ----QLERQNKELRSKLHEMEGAVKSKFKSTIAALE-- 1820

Query: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
              AK+  L++Q++     + +A  S+ Q  ++  E+  +VE+ +   E  +++  +  A+
Sbjct: 1821 --AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878

Query: 673  VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ 732
            V +L+ QL   ++   E +R+   + +LQ +L    ES         E   R  +AL+ +
Sbjct: 1879 VKQLKRQLEEAEE---ESQRINANRRKLQRELDEATES--------NEAMGREVNALKSK 1927

Query: 733  QR------CISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
             R       +   ++  R ++E      +E +   A   G +A
Sbjct: 1928 LRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKA 1970



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 123/561 (21%), Positives = 237/561 (42%), Gaps = 78/561 (13%)

Query: 70   KNRKHPSSPECLV---SAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAE 126
            KNR      + +V   + ++++   E +  K   LL     +SSK   + ++ E + + +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 127  LAVILKFVLDHEDGLNLNEDLE--NFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLEL 184
                L      E+ L   E+LE  N + KA +    SS   +++    H+ ++  R LE 
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALET 1539

Query: 185  QKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLL 244
            Q                             +M+   ++L DE    ++ +L L  N + L
Sbjct: 1540 QME---------------------------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1572

Query: 245  T---EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
                E+D Q    Q    R      +Q    L   E E L D+ +   +      K   D
Sbjct: 1573 KGQFERDLQARDEQNEEKR------RQLQRQLHEYETE-LEDERKQRALAAAAKKKLEGD 1625

Query: 302  LKTEKSQMDRKINQLSE---ENGDLSFKLREFASHLQQLQDALNEL---TEEHSKATQEW 355
            LK  + Q D  I    E   +   L  ++++F   L+  + + +E+    +E+ K  +  
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685

Query: 356  LEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
                 QL+++L+AA + +K  + + E L  +L+      + LQD    EK  +   + QL
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD----EKRRLEARIAQL 1741

Query: 416  -ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG---HFEEEKQQLSSLITDL 471
             E L++E   + A + +++   +  E    Q   +L  ER      E  +QQL     +L
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAE----QLSNELATERSTAQKNESARQQLERQNKEL 1797

Query: 472  QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
            +S +  +  A +          ++  + +A+L +++  L   ++Q+ +E     +  K+K
Sbjct: 1798 RSKLHEMEGAVK----------SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847

Query: 532  QAQLAQTLQQQE---QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE---ATRQDHAQQL 585
              +L + L Q E   + ++  + Q E+ ++ +KQ ++QL+E  E+ +   A R+   ++L
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 586  ATAAEEREASLRERDAALKQL 606
              A E  EA  RE +A   +L
Sbjct: 1908 DEATESNEAMGREVNALKSKL 1928



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 11/220 (5%)

Query: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
            KVK L +  R +EE Q    ++++ +  Q++   +++EL +K +   +   + Q++L+A 
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899

Query: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
                 E+++   RL A+  EL+  L + E   E  + + ++ +       QQ  +L+EQL
Sbjct: 900  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959

Query: 1636 RSLE----QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHAD 1691
               E    +LQ E     A+ ++L  E+     +  +  +  + L  ++  L   +A  +
Sbjct: 960  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 1692 QQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
            ++ ++L K       LK++      +L++ +   + S +E
Sbjct: 1020 EKAKNLTK-------LKNKHESMISELEVRLKKEEKSRQE 1052


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  206 bits (523), Expect = 3e-52
 Identities = 253/1162 (21%), Positives = 512/1162 (44%), Gaps = 171/1162 (14%)

Query: 640  QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
            Q  R++ E+  K +ELQ      ++ Q +A+ ++ ELE     +  + TE++ + QE+ Q
Sbjct: 853  QVTRQEEEMQAKEDELQK----TKERQQKAENELKELE----QKHSQLTEEKNLLQEQLQ 904

Query: 700  LQEQLQALKESLKVT----KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
             + +L A  E ++V     K  LEE        LEE++    +L+AE + + +Q     +
Sbjct: 905  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 756  ELEEERAGRKGL-------EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
            +LEEE A R+ L       EA++++L +    E  V+  +  +    +   E     L  
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 809  EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
             +A   E+ ++  + + ++ +M  E  + LK+E EK+RQEL++ K K+ G  S    QI 
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI- 1078

Query: 869  RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
                  A+L A +A    Q+ +KE   ++L   L+ L +++A  +  + ++  L     +
Sbjct: 1079 ------ADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIRELEGHISD 1129

Query: 929  QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
             QE    E                           +AA    E++   +G ELE L+  L
Sbjct: 1130 LQEDLDSE---------------------------RAARNKAEKQKRDLGEELEALKTEL 1162

Query: 989  ---MESQGQQQEERGQQEREVA------------------RLTQERGRAQADLALE---- 1023
               ++S   QQE R ++E+EV                    + Q+  +A  +L  +    
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222

Query: 1024 KAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL 1083
            K A+A L+   Q  L ++  + A     L  A  E E K ++L        AQ++EL+  
Sbjct: 1223 KRAKANLDKNKQT-LEKENADLAGELRVLGQAKQEVEHKKKKLE-------AQVQELQSK 1274

Query: 1084 ----RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
                 +   +L +++ K + E  S +G  +EA G+       + +L +++   ++  Q++
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334

Query: 1140 --------------QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
                          +E+ +SL+  L+ E  ++   +  + TL  QL +  ++L    S +
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394

Query: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ---VL 1242
             + +     F+ ++++ ++  +E   + A   +  + KN L   L++ V  L+ Q   V 
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 1243 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
              E + ++  +L+  E   S K  +     +AE      +A   + AL E +++ +EE E
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELE 1510

Query: 1303 KQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA--LVSEL 1360
            +    ++ L+ E+       +++G+ +   ++     ++AL T Q+E   TQ   L  EL
Sbjct: 1511 R---TNKMLKAEMEDLVSSKDDVGKNVHELEKS----KRALET-QMEEMKTQLEELEDEL 1562

Query: 1361 LPAKHLCQQLQAEQAAAEKRHREEL----EQSKQAAGGLRAELLRAQRELGE------LI 1410
               +    +L+    A + +   +L    EQ+++    L+ +L   + EL +      L 
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 1411 PLRQKVAEQERTAQQLRAEKA--SYAEQLSMLKKAHGLLAEENRGLGE-RANLGRQFLEV 1467
               +K  E +    +L+A+ A     E +  L+K    + +  R L + RA+    F   
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527
            +     EK  + L A     +  LA  +R  +    E E +  +   +    L  R   Q
Sbjct: 1683 K---ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS----LSGRNALQ 1735

Query: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
            +E+++L A++ QLE    E+   +E +S ++  + Q ++    +L   ++   +++   Q
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795

Query: 1588 RLQAQLNELQAQLSQKE-------------------QAAEHYKLQMEKAKTHYDAKKQQN 1628
            +L+ Q  EL+++L + E                   Q  E  + +  + +    + KQ++
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 1629 QELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
            ++L+E L  +E  +K  ++ + +AE+    ++Q   + +EAE+  + + A  R L+ ++ 
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 1689 HADQQLRDLGKFQVATDALKSR 1710
             A +    +G+     +ALKS+
Sbjct: 1916 EATESNEAMGR---EVNALKSK 1934



 Score =  200 bits (509), Expect = 1e-50
 Identities = 257/1170 (21%), Positives = 510/1170 (43%), Gaps = 110/1170 (9%)

Query: 210  QTPQFQMRRLKKQLADERSNRDELELELAENR--KLLTEKDAQIAMMQQRIDRLALLNEK 267
            Q  + Q +  + Q   ER  + E EL+  E +  +L  EK+     +Q   +  A   E 
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 268  QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
            +     + +ELEE+  + E+   RL E   + Q L+ E+ +M +++  L E+       L
Sbjct: 917  RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQMLDLEEQ-------L 966

Query: 328  REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
             E  +  Q+LQ  L ++T E          K  +LE E+         ++++N  L  + 
Sbjct: 967  EEEEAARQKLQ--LEKVTAE---------AKIKKLEDEILV-------MDDQNNKLSKER 1008

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
              LEE +S L  N  +E+ +       L  LK +  ++ +     +  V + + E+ +QE
Sbjct: 1009 KLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMIS-----ELEVRLKKEEKSRQE 1059

Query: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507
             + L  +   E +       I DLQ+ I+ L     + E+  QA  ARL  ++A   + L
Sbjct: 1060 LEKLKRK--LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 508  TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
                  I++ +  ++ L++    ++A       + E+  + L  ++E L + L   E  L
Sbjct: 1118 ----KKIRELEGHISDLQEDLDSERA----ARNKAEKQKRDLGEELEALKTEL---EDTL 1166

Query: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
               A +QE  R    Q++    +  +   R  +A   Q++ + ++ A  +E L +QL+  
Sbjct: 1167 DSTATQQE-LRAKREQEVTVLKKALDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQF 1222

Query: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
              A+ +   +    ++E A+L+ ++  L    +    ++ + +AQV EL       Q K 
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-------QSKC 1275

Query: 688  TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
            ++ ER   E   L +++  L+  ++   G L E + +A            +L  +  SL 
Sbjct: 1276 SDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAI-----------KLAKDVASLS 1321

Query: 748  EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807
             Q +  ++ L+EE   +  +  +L+QL E    E   L+ +L E M A+   E     L 
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEE----ERNSLQDQLDEEMEAKQNLERHISTLN 1377

Query: 808  KEVAAWRERYED--SQQEEAQYG-AMFQEQLMTLKEECEK---ARQELQEAKEKVAGIES 861
             +++  +++ +D  S  E  + G   FQ+++  L ++ E+   A  +L++ K ++     
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437

Query: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET 921
               + +  Q+  ++ L     +  Q + E++  + K AD+    + +      +   L  
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
             + +A E +E   R      A   D      ++  G+     + + +A+E + E+M  +L
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSS--KDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
            E L   L      Q  E  +   EV  +   +G+ + DL        E   +LQ  L+E 
Sbjct: 1556 EELEDEL------QATEDAKLRLEV-NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
              E    ++  A A   K+  + +L  L     + IK  EE  + +++L+ Q+   ++E 
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ---CQKQQEQADSLERSLEAERASRA 1158
                 ++ E     +    K ++L A++ +L++     ++ ++QAD  +  L  E AS  
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728

Query: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
               +AL+  + +LE +  +L   +  L   Q  + A   +V+  ++  ++   ++A  R 
Sbjct: 1729 SGRNALQDEKRRLEARIAQL---EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESK-ELKRLVMAESEKSQKLEERLRLLQAETA 1277
             A++  S    LE +   L  ++ E EG  K + K  + A   K  +LEE++     E  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 1278 SNSARAAERSSALRE---EVQSLREEAE--KQRVASENLR-QELTSQAERAEELGQELKA 1331
            + +    ++   L+E   +V+  R+ AE  K++    N R ++L  Q E AEE  Q + A
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 1332 WQEKFFQK-EQALSTLQLEHTSTQALVSEL 1360
             + K  ++ ++A  + +       AL S+L
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  194 bits (492), Expect = 1e-48
 Identities = 255/1113 (22%), Positives = 476/1113 (42%), Gaps = 109/1113 (9%)

Query: 242  KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
            K L +   Q   MQ + D L    E+Q  +  E KELE+   +       L E L+   +
Sbjct: 849  KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 302  LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
            L  E  +M  ++    +E  ++   L E  + L++ +D   +L  E  K  Q+ L+ + Q
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEI---LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 362  LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQD--NPPQEKGEVLGD-VLQLETL 418
            LE+E +A    ++ L+ +    + K+ +LE+ +  + D  N   ++ ++L + +  L T 
Sbjct: 966  LEEEEAA----RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 419  KQEAATLAANNTQLQAR---------VEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469
              E    A N T+L+ +         V + + E+ +QE + L  +   E +       I 
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIA 1079

Query: 470  DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLN------ATIQQQ-DQELA 522
            DLQ+ I+ L     + E+  QA  ARL  ++A   + L  +       + +Q+  D E A
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139

Query: 523  GLKQQAKEKQ----------AQLAQTLQQQEQASQGLRHQVEQLSSSLKQK--EQQLKEV 570
               +  K+K+           +L  TL       Q LR + EQ  + LK+   E+     
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTA-TQQELRAKREQEVTVLKKALDEETRSHE 1198

Query: 571  AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA---AKLEILQQQLQVA 627
            A+ QE  RQ HAQ +    E+ E   R +    K  + LEKE A    +L +L Q  Q  
Sbjct: 1199 AQVQEM-RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257

Query: 628  NEARDSAQTSVTQAQ-------REKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
               +   +  V + Q       R +AEL+ KV +LQ  VE+     +EA+ +  +L   +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
             S   +  + + + QE     E  Q L  S K+ +  LEEE+    D L+E+      L+
Sbjct: 1318 ASLSSQLQDTQELLQE-----ETRQKLNVSTKLRQ--LEEERNSLQDQLDEEMEAKQNLE 1370

Query: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA----- 795
                +L  Q    +K+L++  +  + LE   ++     Q E E L ++  E  AA     
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF----QKEIENLTQQYEEKAAAYDKLE 1426

Query: 796  --QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
              ++  + E + LV ++   R+   + ++++ ++  +  E+     +  ++  +   EA+
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 854  EKVA-----------GIESHSELQ-----ISRQQNELAELHANLARALQQVQEK----EV 893
            EK              +E+  EL+     +  +  +L     ++ + + ++++     E 
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 894  RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQET---ASRELVKEPARAGDRQPE 950
            + +++   L  L++++ AT     RLE  ++    Q E    A  E  +E  R   RQ  
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 951  WLE---EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVA 1007
              E   E + +Q     AA + +E + + +  EL+   A     +  +Q  + Q + +  
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQLRKLQAQMKDF 1664

Query: 1008 RLTQERGRAQADLALEKAARAELEMR-LQNALNEQRVEFATLQEALAHALTEKEGKDQEL 1066
            +   E  RA  D     A   E + + L+  L + + + A  + A   A  EKE   +EL
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724

Query: 1067 AK-LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
            A  L G  A Q  E   L   + QL+E+L +++    + S    +A  + E    +L   
Sbjct: 1725 ASSLSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783

Query: 1126 RAEVSKLE---QQCQKQQEQADSLERSLEAERASR-----AERDSALETLQGQLEEKAQE 1177
            R+   K E   QQ ++Q ++  S    +E    S+     A  ++ +  L+ Q+E++A+E
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843

Query: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
               +  +L    ++L     +V+D  K  +++K Q  +G    ++    +   EEE   +
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903

Query: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
            N    + + E  E      A   +   L+ +LR
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  189 bits (479), Expect = 3e-47
 Identities = 255/1179 (21%), Positives = 488/1179 (41%), Gaps = 145/1179 (12%)

Query: 495  RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
            RL  +V  L  ++T     +Q ++ EL    Q+ KE+Q +    L++ EQ    L  +  
Sbjct: 843  RLFTKVKPLL-QVTRQEEEMQAKEDEL----QKTKERQQKAENELKELEQKHSQLTEEKN 897

Query: 555  QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
             L   L Q E +L   AE+         Q+L     E EA L E +   +QL+A  K+ A
Sbjct: 898  LLQEQL-QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956

Query: 615  AKLEILQQQLQVANEARDSAQTS----------------VTQAQREKAELSRKV--EELQ 656
             ++  L++QL+    AR   Q                  V   Q  K    RK+  E + 
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016

Query: 657  ACVETARQEQHEA----------QAQVAELELQLRSEQQKATEKERVAQ----EKDQLQE 702
                   +E+ +A          ++ ++ELE++L+ E++   E E++ +    +     E
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076

Query: 703  Q---LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
            Q   LQA    LK+     EEE + A   L+++    +    + R L       +++L+ 
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY-E 818
            ERA R   E + + LGE    E E L+ EL + + +  T +    +  +EV   ++   E
Sbjct: 1137 ERAARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
            +++  EAQ   M Q+    ++E  E    +L++ K   A ++ + +      + E A+L 
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTE----QLEQFKRAKANLDKNKQ----TLEKENADLA 1244

Query: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
              L    Q  QE E + +KL   +  LQ K +   +  A L   V K   + E+ +  L 
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304

Query: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL---RAALMESQGQQ 995
            +   +A     +        Q   TQ  LQ   R+   +  +L +L   R +L +   ++
Sbjct: 1305 EAEGKAIKLAKD--VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362

Query: 996  QEERGQQEREVARLT---QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052
             E +   ER ++ L     +  +   D A    A  E + R Q  +     ++     A 
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
                  K    QEL  L       + +L+  RQ V  L+++  K ++  A      S+ A
Sbjct: 1423 DKLEKTKNRLQQELDDL-------VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
                           E  + E + ++++ +A SL R+LE    ++ E +   + L+ ++E
Sbjct: 1476 D--------------ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 1173 E----------KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE-----------WKA 1211
            +             EL  S+ AL +   E+     +++D  +A ++            K 
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR- 1270
            Q  R  Q  + +N      EE+   L RQ+ E E E ++ ++     +   +KLE  L+ 
Sbjct: 1582 QFERDLQARDEQN------EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 1271 -LLQAETA-SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
              LQA++A      A ++   L+ +++  + E E  R + + +        ++A+ L  +
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
            L   QE     E+A     LE             A+ L   L    A  +++ R E   +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEEL---------AEELASSLSGRNALQDEKRRLEARIA 1746

Query: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
            +     L  EL   + E G +  +  +V +  + A+QL  E A+        + A   L 
Sbjct: 1747 Q-----LEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798

Query: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
             +N+ L  + +      E+E    + K+   +AA+    E ++A+++ + +  ARE +  
Sbjct: 1799 RQNKELRSKLH------EME-GAVKSKFKSTIAAL----EAKIAQLEEQVEQEAREKQAA 1847

Query: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
            T   +    K+ E   + ++ER+      EQ E    +   +V++L ++L ++++ S+  
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE----KGNARVKQLKRQLEEAEEESQRI 1903

Query: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
                + +Q +  E+ +  + +  ++N L+++L +  + +
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942



 Score =  184 bits (468), Expect = 6e-46
 Identities = 243/1049 (23%), Positives = 442/1049 (42%), Gaps = 115/1049 (10%)

Query: 730  EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL 789
            EE Q    EL+ +T+   ++ + E KELE++ +    L      L E  QAETE L  E 
Sbjct: 859  EEMQAKEDELQ-KTKERQQKAENELKELEQKHSQ---LTEEKNLLQEQLQAETE-LYAEA 913

Query: 790  AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK---AR 846
             E        + E E+++ E+ A  E  ED  Q+         +Q++ L+E+ E+   AR
Sbjct: 914  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 847  QELQ----EAKEKVAGIESH------SELQISRQQNELAELHANLARALQQVQEKEVRAQ 896
            Q+LQ     A+ K+  +E           ++S+++  L E  ++L   L + +EK     
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 897  KLADD----LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
            KL +     +S L+ ++    K    LE L RK          ++    A+  + + +  
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 953  EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE 1012
            ++++       QAAL  ++ E  Q  N L+++R   +E      +E    ER      ++
Sbjct: 1094 KKEE-----ELQAALARLDDEIAQKNNALKKIRE--LEGHISDLQEDLDSERAARNKAEK 1146

Query: 1013 RGRAQADLALE-KAARAELEMRLQNALNEQRVEFATLQEA--LAHALTEKEGKDQELAKL 1069
            + R   DL  E +A + ELE  L +   +Q +     QE   L  AL E+    +  A++
Sbjct: 1147 QKR---DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE--AQV 1201

Query: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
            + +     + +EEL + ++Q K   A  +K   +     ++ AG     G   + +  + 
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261

Query: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
             KLE Q Q+ Q +    ER+       RAE +  +  LQ ++E     L  ++       
Sbjct: 1262 KKLEAQVQELQSKCSDGERA-------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1190 RELAAFRTKVQDHSKAEDEWKAQV----ARGRQEAERKNSLISSLEEEVSILNRQVLEKE 1245
            +++A+  +++QD  +   E   Q      + RQ  E +NSL   L+EE+           
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM----------- 1363

Query: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
                          E  Q LE  +  L  + + +  +  + +S     V++L E  ++ +
Sbjct: 1364 --------------EAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQ 1405

Query: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
               ENL Q+   +A   ++L +     Q       Q L  L ++  + + LVS L   + 
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQ-------QELDDLVVDLDNQRQLVSNLEKKQR 1458

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
               QL AE+     ++ +E ++++  A     + L   R L E +  ++   E ERT + 
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKM 1515

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLG---ERANLGRQFLEVEL---DQAREKYVQE 1479
            L+AE          + K    L +  R L    E      + LE EL   + A+ +    
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575

Query: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
            + A++   E  L     + +   R+L+    +YE       ++R      ++KL   ++ 
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ-------GGESQQEAQRLQAQ 1592
            LE+      K  EE  K+L       K  Q++L+  +A          E++++A+ L+A 
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648
            L +LQ  L+  E+A +   L+ E+      +       LQ++ R LE    QL++E +E 
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755

Query: 1649 RAEAERLGHELQQAGLKTKEAEQTCRHL-----TAQV-RSLEAQVAHADQQLRDLGKFQV 1702
            +   E +   +++A   T++AEQ    L     TAQ   S   Q+   +++LR   K   
Sbjct: 1756 QGNMEAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELR--SKLHE 1810

Query: 1703 ATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
               A+KS+       L+  I  L+   E+
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839



 Score =  166 bits (421), Expect = 2e-40
 Identities = 222/1004 (22%), Positives = 431/1004 (42%), Gaps = 116/1004 (11%)

Query: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA----LLNEK--- 267
            QM  L++QL +E + R +L+LE       + + + +I +M  + ++L+    LL E+   
Sbjct: 958  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 268  ----QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI----NQLSEE 319
                 A    + K L +L++K+ES+   L   LK+ +  + E  ++ RK+    +   E+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 320  NGDLSFKLREFASHL----QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD--- 372
              DL  ++ E    L    ++LQ AL  L +E ++     L+K  +LE  +S   +D   
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA-LKKIRELEGHISDLQEDLDS 1136

Query: 373  -----------KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV--LGDVLQLETLK 419
                       K+ L E+ E L+ +L    +  +  Q+   + + EV  L   L  ET  
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 420  QEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLS 479
             EA          QA  E+ E     + AK      + ++ KQ L     DL   +  L 
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAK-----ANLDKNKQTLEKENADLAGELRVLG 1251

Query: 480  QAKEELEQASQAHGARLTAQVASLTS----------ELTTLNATIQQQDQELAGLKQQAK 529
            QAK+E+E   +    +L AQV  L S          EL      +Q + + + G+  +A+
Sbjct: 1252 QAKQEVEHKKK----KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 530  EKQAQLAQT-------LQQQEQASQGLRHQVEQLSSSLKQKEQQLK----EVAEKQEATR 578
             K  +LA+        LQ  ++  Q    Q   +S+ L+Q E++      ++ E+ EA +
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367

Query: 579  --QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
              + H   L     + +  L++  + ++ LE  +K    ++E L QQ +    A D  + 
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 637  SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE--------QQKAT 688
            +  + Q+E  +L   ++  +  V    ++Q +    +AE E  + S+        + +A 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 1486

Query: 689  EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL-- 746
            EKE  A    +  E+    KE L+ T   L+ E      + ++  + + EL+   R+L  
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 747  -VEQHKRERKELEEERAGRKG----LEARLQQLG-------EAHQAETEVLRRELAEAMA 794
             +E+ K + +ELE+E    +     LE  +Q L        +A   + E  RR+L   + 
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 795  AQHTA-ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ------EQLMTLKEECEKARQ 847
               T  E E +Q     AA ++   D +  E Q  +  +      +QL  L+ + +  ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 848  ELQEAK---EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLST 904
            EL++A+   +++      +E +    + +L +L  +LA A +  ++ ++  ++LA++L++
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 905  LQEKMAATSKEVARLETLVRKAGEQ--QETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962
                  A   E  RLE  + +  E+  +E  + E + +  R   +Q E L  +   +  +
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786

Query: 963  TQ---AALQAMEREAEQMGNELERLRAAL----------MESQGQQQEERGQQEREVARL 1009
             Q   +A Q +ER+ +++ ++L  +  A+          +E++  Q EE+ +QE    + 
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 1010 TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069
              +  + +     E   + E E ++     EQ  +     + L   L E E + Q +   
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906

Query: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
            R     ++ E  E  + + +    L  K +     S   S  +G
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1950



 Score =  112 bits (280), Expect = 4e-24
 Identities = 134/583 (22%), Positives = 261/583 (44%), Gaps = 67/583 (11%)

Query: 218  RLKKQLAD---ERSNRDELELELAENRK-----LLTEKDAQIAMMQQRIDRLALLNEKQA 269
            RL+++L D   +  N+ +L   L + ++     L  EK+       +R    A   EK+ 
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 270  ASPLEPKELEELRDKNESLTMRLHETLK-QCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
             +    + LEE  +  E L  R ++ LK + +DL + K  + + +++L +    L  ++ 
Sbjct: 1491 KALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 329  EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS 388
            E  + L++L+D L    +   +        + Q E++L A  +     EEK   LQ    
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN---EEKRRQLQ---R 1603

Query: 389  QLEEHLSQLQDNPPQE------KGEVLGDVLQLETLKQEAATLAANNTQLQAR---VEML 439
            QL E+ ++L+D   Q       K ++ GD+  LE L+ ++A         Q R    +M 
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-LQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 440  ETERGQQEAKLLAER--GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
            + +R  ++A+   +      +E +++  SL  DL     +L+ A+   +QA       L 
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD-LEKEELA 1721

Query: 498  AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
             ++AS  S    L    ++ +  +A L+++ +E+Q  +     +  +A+Q    Q EQLS
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ----QAEQLS 1777

Query: 558  SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ-----LEALEKE 612
            + L  +    +  A+K E+ RQ    QL    +E  + L E + A+K      + ALE  
Sbjct: 1778 NELATE----RSTAQKNESARQ----QLERQNKELRSKLHEMEGAVKSKFKSTIAALE-- 1827

Query: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
              AK+  L++Q++     + +A  S+ Q  ++  E+  +VE+ +   E  +++  +  A+
Sbjct: 1828 --AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885

Query: 673  VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ 732
            V +L+ QL   ++   E +R+   + +LQ +L    ES         E   R  +AL+ +
Sbjct: 1886 VKQLKRQLEEAEE---ESQRINANRRKLQRELDEATES--------NEAMGREVNALKSK 1934

Query: 733  QR------CISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
             R       +   ++  R ++E      +E +   A   G +A
Sbjct: 1935 LRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKA 1977



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 123/561 (21%), Positives = 237/561 (42%), Gaps = 78/561 (13%)

Query: 70   KNRKHPSSPECLV---SAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAE 126
            KNR      + +V   + ++++   E +  K   LL     +SSK   + ++ E + + +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 127  LAVILKFVLDHEDGLNLNEDLE--NFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLEL 184
                L      E+ L   E+LE  N + KA +    SS   +++    H+ ++  R LE 
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALET 1546

Query: 185  QKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLL 244
            Q                             +M+   ++L DE    ++ +L L  N + L
Sbjct: 1547 QME---------------------------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1579

Query: 245  T---EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
                E+D Q    Q    R      +Q    L   E E L D+ +   +      K   D
Sbjct: 1580 KGQFERDLQARDEQNEEKR------RQLQRQLHEYETE-LEDERKQRALAAAAKKKLEGD 1632

Query: 302  LKTEKSQMDRKINQLSE---ENGDLSFKLREFASHLQQLQDALNEL---TEEHSKATQEW 355
            LK  + Q D  I    E   +   L  ++++F   L+  + + +E+    +E+ K  +  
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692

Query: 356  LEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
                 QL+++L+AA + +K  + + E L  +L+      + LQD    EK  +   + QL
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD----EKRRLEARIAQL 1748

Query: 416  -ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG---HFEEEKQQLSSLITDL 471
             E L++E   + A + +++   +  E    Q   +L  ER      E  +QQL     +L
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAE----QLSNELATERSTAQKNESARQQLERQNKEL 1804

Query: 472  QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
            +S +  +  A +          ++  + +A+L +++  L   ++Q+ +E     +  K+K
Sbjct: 1805 RSKLHEMEGAVK----------SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854

Query: 532  QAQLAQTLQQQE---QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE---ATRQDHAQQL 585
              +L + L Q E   + ++  + Q E+ ++ +KQ ++QL+E  E+ +   A R+   ++L
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 586  ATAAEEREASLRERDAALKQL 606
              A E  EA  RE +A   +L
Sbjct: 1915 DEATESNEAMGREVNALKSKL 1935



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 11/220 (5%)

Query: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
            KVK L +  R +EE Q    ++++ +  Q++   +++EL +K +   +   + Q++L+A 
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906

Query: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
                 E+++   RL A+  EL+  L + E   E  + + ++ +       QQ  +L+EQL
Sbjct: 907  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966

Query: 1636 RSLE----QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHAD 1691
               E    +LQ E     A+ ++L  E+     +  +  +  + L  ++  L   +A  +
Sbjct: 967  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 1692 QQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
            ++ ++L K       LK++      +L++ +   + S +E
Sbjct: 1027 EKAKNLTK-------LKNKHESMISELEVRLKKEEKSRQE 1059


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  204 bits (520), Expect = 6e-52
 Identities = 394/1930 (20%), Positives = 787/1930 (40%), Gaps = 280/1930 (14%)

Query: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275
            ++RL ++L +  + + EL+L+L E    L   D  +   ++R+++     EK+       
Sbjct: 145  VKRLNEKLKESNTTKGELQLKLDE----LQASDVSVKYREKRLEQ-----EKELLHSQNT 195

Query: 276  KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
                EL+ K + L     E   +  +LK        ++++L E+   L         H++
Sbjct: 196  WLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE 255

Query: 336  QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
             L   L E  E+ +   +++         EL+A +               KLS L +  +
Sbjct: 256  DLLTKLKEAKEQQASMEEKF-------HNELNAHI---------------KLSNLYKSAA 293

Query: 396  QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
               D+   +  E+   V +L  L +EA      N  +Q  +  +E  + Q E ++L + G
Sbjct: 294  ---DDSEAKSNELTRAVEELHKLLKEAGEA---NKAIQDHLLEVEQSKDQMEKEMLEKIG 347

Query: 456  HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL-NATI 514
              E+E +  + L++  +   + LS+  EEL  A+ +  A   A++     +LT L NA +
Sbjct: 348  RLEKELENANDLLSATKRKGAILSE--EEL--AAMSPTAAAVAKIVKPGMKLTELYNAYV 403

Query: 515  QQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK-------QKEQQL 567
            + QDQ L   K + K     L + +++ E  +  L+ Q E+   + K       + EQ +
Sbjct: 404  ETQDQLLLE-KLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462

Query: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK-QLEALEKEKAAKLEILQQQLQV 626
            KE+   QE T + + Q      + R   ++ +D + + ++  +E E+A    +++ +   
Sbjct: 463  KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522

Query: 627  ANEARDSAQT---------SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE 677
            + +   S++          ++ + Q++   L   + EL    E  R+EQ    +++ EL+
Sbjct: 523  SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRE--REEQETTSSKITELQ 580

Query: 678  LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKV----TKG--------SLEEEKRRA 725
            L+L S   +  +  +  Q + QL + +   ++  ++    T G        SL++    +
Sbjct: 581  LKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAS 640

Query: 726  ADALEEQQRCIS--------------ELKAETRSLVEQHKRERKE-LEEERAGRKGLEAR 770
                    + +S              E KA  + L E  +  +KE  E E+   + LE  
Sbjct: 641  TPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKL 700

Query: 771  LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED----SQQEEAQ 826
             +Q+ +     T++   +L  A       +   E   +E+ +  ER +     +Q++E  
Sbjct: 701  QEQVTDLRSQNTKI-STQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759

Query: 827  YGAMFQ------EQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE------L 874
               M Q      E+L   +   E  ++E +  K     +    E  ++ Q+ +      L
Sbjct: 760  INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819

Query: 875  AELHANLARALQQVQEK-EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
              +   L R+  + +++   + +KL  ++S L++K+     EV +  TL R    Q    
Sbjct: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKL---ENEVEQRHTLTRNLDVQLLDT 876

Query: 934  SREL---------VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE-QMGN--EL 981
             R+L          KE  +   ++   L++         Q A Q+ +R  + Q  N  ++
Sbjct: 877  KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVASQSSQRTGKGQPSNKEDV 934

Query: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRA---QADLALEKAARAELEMRLQNAL 1038
            + L + L +++ Q  + + + +   + + Q +      +  L  EK    E+   ++  L
Sbjct: 935  DDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRL 994

Query: 1039 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098
             E     A  Q  L   L E E + QEL              ++ R+ ++ +++QL++ +
Sbjct: 995  KES----AEFQTQLEKKLMEVEKEKQELQ-------------DDKRRAIESMEQQLSELK 1037

Query: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158
            K  +S      EA  R         AL  E  +  + CQ+Q + A   +   E E    A
Sbjct: 1038 KTLSSVQNEVQEALQRAST------ALSNE-QQARRDCQEQAKIAVEAQNKYERELMLHA 1090

Query: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA-EDEWKAQVARGR 1217
                AL+  + Q+ + A    H +     A+ +L   +   ++  +  +DE    V R  
Sbjct: 1091 ADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRC- 1149

Query: 1218 QEAERKNSLISSLEEEVSILNRQVLE--KEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275
            ++ E++N L   L +++  L+ +V+   KEG    L   +  E +  +++ E LR ++ E
Sbjct: 1150 EDLEKQNRL---LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE 1206

Query: 1276 TASNSAR---AAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAW 1332
                  R   A   S   R+ V+ L  E ++       L+  L ++ E+ +   + + A 
Sbjct: 1207 KEIAETRFEVAQVESLRYRQRVELLERELQE-------LQDSLNAEREKVQVTAKTM-AQ 1258

Query: 1333 QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELE-QSKQA 1391
             E+  +K + ++ +      T  ++ E    + L Q LQ  QA   K   + L  Q   A
Sbjct: 1259 HEELMKKTETMNVVM----ETNKMLRE--EKERLEQDLQQMQAKVRKLELDILPLQEANA 1312

Query: 1392 AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ----------LRAEKASYAEQLSMLK 1441
                ++ +L+A+++L E    R K   Q   +QQ          L +EK  + +++  L 
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLT 1372

Query: 1442 KAHGLL----AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497
            +  G L    A  N  L    NL  Q L+ +L++ R     E   ++ D + ++ ++Q +
Sbjct: 1373 EEIGRLKAEIARSNASLTNNQNL-IQSLKEDLNKVRT----EKETIQKDLDAKIIDIQEK 1427

Query: 1498 AQSTARELEV---MTAKYEGAKV---KVLE----------ERQRFQEERQKLTAQVEQLE 1541
             ++  +  ++      +YE  K    KV+E          E+    +E Q+L   + Q E
Sbjct: 1428 VKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAE 1487

Query: 1542 VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601
               +    QVE L K L++ +  ++  Q++   +Q++    +Q+ Q    Q  +L+ Q++
Sbjct: 1488 TKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQIT 1547

Query: 1602 QKEQAAEHYKLQMEKAKTHYDAKKQQ----NQELQEQLRSLEQLQKENKELRAEAERLGH 1657
            +KE+      +  +    H    K Q    N+EL+++  +L+Q QK+  ++R  A +  +
Sbjct: 1548 EKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ-QKDELDVRITALKSQY 1606

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATD----ALKSREPQ 1713
            E + + L+ +  E   RHL  +    E      +QQ +   K   A+     A  S  P 
Sbjct: 1607 EGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPT 1666

Query: 1714 A--KPQLDLS----IDSLDLSCEEGTPLSITSKL--PRTQPDGTSVPGEPASPISQRLPP 1765
            A  KP   +S    + +  ++  + TP +    +  P T  + T+ P     P +Q    
Sbjct: 1667 ANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQ---- 1722

Query: 1766 KVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDV 1825
             VES E++       +S+ P+E        VF      T  + R T+  +  ++++ +  
Sbjct: 1723 -VESQEAM-------QSEGPVEHV-----PVF----GSTSGSVRSTSPNVQPSISQPILT 1765

Query: 1826 EEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSAR 1885
             +  +  ++F      P  Q+  +   + Q L         +S ++ +    P  R S  
Sbjct: 1766 VQQQTQATAFVQ----PTQQSHPQIEPANQEL---------SSNIVEVVQSSPVERPSTS 1812

Query: 1886 RSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPS 1945
             +  G  S  P   +S    T ++E +   + +            P  LK+  P+ +   
Sbjct: 1813 TAVFGTVSATP--SSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSVTPVGTEEE 1870

Query: 1946 LSLGTITDEEMKT----GDPQETLRRASMQ----PIQIAEGT--------GITTRQQRKR 1989
            +     TD E++T     D Q+++     Q    P++ +E T        G     Q+  
Sbjct: 1871 VMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTT 1930

Query: 1990 VSLEPHQGPG 1999
             S +  QG G
Sbjct: 1931 TSSQDGQGKG 1940



 Score =  203 bits (517), Expect = 1e-51
 Identities = 355/1697 (20%), Positives = 678/1697 (39%), Gaps = 218/1697 (12%)

Query: 251  IAMMQQRIDRLALLNEK-QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQM 309
            +A  Q  ID L   +EK +  S  +  E+E+    ++    RL    ++CQ L+ E  ++
Sbjct: 29   LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE---RLVNETRECQSLRLELEKL 85

Query: 310  DRKINQLSEENGDLSF-KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA 368
            + ++  L+E+N +L   + R  A     +Q       EE     ++ +    +L +EL  
Sbjct: 86   NNQLKALTEKNKELEIAQDRNIA-----IQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140

Query: 369  ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428
              +D K L EK +       +L+  L +LQ +    K        + + L+QE   L + 
Sbjct: 141  LTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK-------YREKRLEQEKELLHSQ 193

Query: 429  NTQLQARVE-------MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS------- 474
            NT L   ++        L  E+G +  +L     + +EE  +L   +  L++S       
Sbjct: 194  NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253

Query: 475  ----ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530
                ++ L +AKE+     +     L A +     +L+ L  +     +  +    +A E
Sbjct: 254  VEDLLTKLKEAKEQQASMEEKFHNELNAHI-----KLSNLYKSAADDSEAKSNELTRAVE 308

Query: 531  KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590
               +L + L++  +A++ ++  + ++  S  Q E+++ E   + E    ++A  L +A +
Sbjct: 309  ---ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE-KELENANDLLSATK 364

Query: 591  EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN-EARDSAQTSVTQAQREKAELS 649
             + A L E + A     A    K  K  +   +L  A  E +D       + +R    L 
Sbjct: 365  RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLD 424

Query: 650  RKVEELQA---CVETARQEQHEAQAQVAEL---------ELQLRSEQQKATEKERVAQEK 697
              V+E++A    ++  R+E   AQ  VA L         E+Q   E      K+    E+
Sbjct: 425  EIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLER 484

Query: 698  DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKEL 757
            D  + ++Q    S ++    +E E+ R    + +++   +++ + +  ++ QH    + +
Sbjct: 485  DNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSS-EVISQHLVSYRNI 543

Query: 758  EEERAGRKGLEARLQQLGEAHQ-AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
            EE +   + L   L++LGE  +  E E    ++ E      +A +E EQL K      + 
Sbjct: 544  EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQL 603

Query: 817  YEDSQQEEAQYGAMFQEQL---------------------------------------MT 837
             +   ++   Y  +  +                                          T
Sbjct: 604  VDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST 663

Query: 838  LKEECEKARQELQEA----KEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893
               E + A ++LQE     K++ A  E     Q+ + Q ++ +L +   +   Q+     
Sbjct: 664  EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASK 723

Query: 894  RAQKLAD-------DLSTLQEK----MAATSKEVARLETL---VRKAGEQQETA------ 933
            R + L D       ++++L E+     A T K+   + T+   +R A E+   A      
Sbjct: 724  RYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN 783

Query: 934  ---SRELVK-EPARAGDRQPEWLEEQQGRQFCST-----QAALQAMEREAEQ-MGNELER 983
                +E++K    R   ++   L EQ+G+    T     Q  L+  E E +Q + +++E+
Sbjct: 784  LKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843

Query: 984  LRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRV 1043
            L   +   + + + E  Q+      LT+       D   +      L +  +  L   + 
Sbjct: 844  LEHEISHLKKKLENEVEQRH----TLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQK 899

Query: 1044 EFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKEL-EELRQT---VKQLKEQL---A 1095
            E ATL++ L++   +   +  Q   K +      + +L  +LRQT   V  LKE+L    
Sbjct: 900  EIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTST 959

Query: 1096 KKEKEHASGSGAQSEAAGR----TEPTGPKLEALRAEVSKLEQQCQK--------QQEQA 1143
               +++ +   +  E+  +    TE     +E    E ++ + Q +K        +QE  
Sbjct: 960  SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019

Query: 1144 DSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-AAFRTKVQDH 1202
            D   R++E+     +E    L ++Q +++E  Q    + S    A+R+     +  V+  
Sbjct: 1020 DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ 1079

Query: 1203 SKAEDEWKAQVA------RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVM 1256
            +K E E     A        +++  +  S+   LEE       Q+LE +   +E +R++ 
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139

Query: 1257 AESEK----SQKLEERLRLL--QAETASNSARAAERSSALREEVQSLREEAEKQRVASEN 1310
             E  K     + LE++ RLL  Q E  S+   A+ +         SL EE + Q    E 
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199

Query: 1311 L---RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ----LEHTSTQALVSELLPA 1363
            L   R+E      R E    E   ++++    E+ L  LQ     E    Q     +   
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQH 1259

Query: 1364 KHLCQQLQAEQAAAE--KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER 1421
            + L ++ +      E  K  REE E+ +Q    ++A++ + +    +++PL++  AE   
Sbjct: 1260 EELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL---DILPLQEANAELSE 1316

Query: 1422 TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE---RANLGRQFLEVELDQAREKYVQ 1478
             +  L+AEK    E +   K  +  L  + +       R  L  + +  +  Q   + + 
Sbjct: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376

Query: 1479 ELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1538
             L A  A +   L   Q   QS   +L            KV  E++  Q++   L A++ 
Sbjct: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLN-----------KVRTEKETIQKD---LDAKI- 1421

Query: 1539 QLEVFQREQT-KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597
             +++ ++ +T  QV+++ ++     +  K QQ K+    AQ     QE      ++ EL+
Sbjct: 1422 -IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK 1480

Query: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
              L+Q E  ++  + Q+E  +     K+ + + LQEQ     QLQ E   LR + +    
Sbjct: 1481 ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQ---TVQLQSELSRLRQDLQDRTT 1537

Query: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE---PQA 1714
            + +Q   +  E E+  R      +S  A +A    QL          + LK R     Q 
Sbjct: 1538 QEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK------ENEELKQRNGALDQQ 1591

Query: 1715 KPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLY 1774
            K +LD+ I +L  S  EG    +  +L   Q        EP  P S ++P   E    + 
Sbjct: 1592 KDELDVRITALK-SQYEGRISRLERELREHQERHLEQRDEPQEP-SNKVP---EQQRQIT 1646

Query: 1775 FTPIPARSQAPLESSLD 1791
                PA  +  + S+ D
Sbjct: 1647 LKTTPASGERGIASTSD 1663



 Score =  161 bits (407), Expect = 7e-39
 Identities = 281/1347 (20%), Positives = 533/1347 (39%), Gaps = 235/1347 (17%)

Query: 512  ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
            A + QQ  E   L +  K  Q +L + L  Q+    GL+ + E+      + EQQ  E+ 
Sbjct: 2    AAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKV---ESEQQYFEIE 58

Query: 572  EKQEATRQDHAQQ-LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
            +     R  H+Q+ L     E ++   E +    QL+AL ++         ++L++A + 
Sbjct: 59   K-----RLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN--------KELEIAQDR 105

Query: 631  RDSAQTSVTQAQREKAELSRKVEELQA-------------------CVETARQEQHEAQA 671
              + Q+  T+ +          EEL+A                     +  R  +   ++
Sbjct: 106  NIAIQSQFTRTK----------EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKES 155

Query: 672  QVAELELQLRSEQQKATE------KERVAQEKDQLQEQLQALKESLKVTKGSL------- 718
               + ELQL+ ++ +A++      ++R+ QEK+ L  Q   L   LK     L       
Sbjct: 156  NTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREK 215

Query: 719  ----------EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK--- 765
                       E K+     LEEQ   +       +  VE    + KE +E++A  +   
Sbjct: 216  GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275

Query: 766  ----GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
                    +L  L ++   ++E    EL  A+   H    E  +  K +   ++   + +
Sbjct: 276  HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI---QDHLLEVE 332

Query: 822  QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK-------------------------- 855
            Q + Q      E++  L++E E A   L   K K                          
Sbjct: 333  QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392

Query: 856  -------VAGIESHSELQISRQQNE---------LAELHANLARALQQVQEKEVRAQKLA 899
                    A +E+  +L + + +N+         + E+ A  A  L++ +E+  RAQK  
Sbjct: 393  MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAK-APILKRQREEYERAQKAV 451

Query: 900  DDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE------WLE 953
              LS    K+    KE+ RL+    KA +Q     R+  +   +  D   +       LE
Sbjct: 452  ASLSV---KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE 508

Query: 954  EQQGRQFCSTQAALQA--------------MEREAEQMGNELERLRAALMESQGQQQEER 999
            E +G      +    A                R  E++  + +RL  AL E    +  ER
Sbjct: 509  EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL--GETRER 566

Query: 1000 GQQEREVARLTQERGRAQADLA-LEKAARA-ELEMRLQNALNEQR--------------- 1042
             +QE   +++T+ + + ++ L  LE+  ++ + +M+L +++  QR               
Sbjct: 567  EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626

Query: 1043 -VEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
             +  ++L +    +  ++    Q ++    +   +  E  E +  +KQL+E     +KE 
Sbjct: 627  PLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEK 686

Query: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERD 1161
            A     Q+E   + E    ++  LR++ +K+  Q     ++ + L+ ++E  R       
Sbjct: 687  AENEKIQNE---QLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLH 743

Query: 1162 SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
               + L    +++ Q +      L  A  +LA    + ++  K ++  K    R  Q+ E
Sbjct: 744  ERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRE 803

Query: 1222 R-------KNSLISSLEEEVSILNRQVLE-KEGESKELKRLVMAESEKSQKLEERLRLLQ 1273
                    +N L+++L+    IL R   E K+  S ++++L    S   +KLE  +    
Sbjct: 804  SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRH 863

Query: 1274 AETAS------NSARAAERSSALREEVQSLREEAEKQ----RVASENLRQELTSQAERAE 1323
              T +      ++ R  +  + L    + L + A+K+    +    N+  ++ SQ+ +  
Sbjct: 864  TLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRT 923

Query: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
              GQ            +  +S L+        L   L  +    +Q QA   + E    E
Sbjct: 924  GKGQ-----PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE----E 974

Query: 1384 ELEQSKQAAGGLRAELLRAQRELGEL-IPLRQKVAEQERTAQQLRAEK----ASYAEQLS 1438
             L + KQ    +R  +    +E  E    L +K+ E E+  Q+L+ +K     S  +QLS
Sbjct: 975  SLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLS 1034

Query: 1439 MLKKAHGLLAEENRGLGERANL-------GRQFLEVELD---QAREKYVQELAAVRADAE 1488
             LKK    +  E +   +RA+         R+  + +     +A+ KY +EL    AD E
Sbjct: 1035 ELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094

Query: 1489 TRLAEVQREAQ--STARELEVMTAKYEGAKVKV---LEERQR-FQEERQKLTAQVEQLEV 1542
               A  ++ ++  S  + LE  T K E   ++     EER+R  ++E  K   + E LE 
Sbjct: 1095 ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEK 1154

Query: 1543 FQREQTKQVEELSKKLADS-------------DQASKVQQQKLKAV-----QAQGGESQQ 1584
              R    Q+E+LS K+  S              +  K Q+Q L+ +     + +  E++ 
Sbjct: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214

Query: 1585 EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ-QNQELQEQLRSLEQLQK 1643
            E  ++++     + +L ++E       L  E+ K    AK   Q++EL ++  ++  + +
Sbjct: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVME 1274

Query: 1644 ENKELRAEAERLGHELQQAGLKTKEAE 1670
             NK LR E ERL  +LQQ   K ++ E
Sbjct: 1275 TNKMLREEKERLEQDLQQMQAKVRKLE 1301


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  204 bits (519), Expect = 7e-52
 Identities = 276/1236 (22%), Positives = 535/1236 (43%), Gaps = 150/1236 (12%)

Query: 506  ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ 565
            ++T     +Q +D+EL     + KEKQ ++   L++ E+  Q L  +   L+  L Q E 
Sbjct: 846  QVTRQEEELQAKDEELL----KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL-QAET 900

Query: 566  QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625
            +L   AE+  A      Q+L     + E+ + E +   + L+  +K+  A ++ L++QL 
Sbjct: 901  ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960

Query: 626  VANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ 685
                AR   Q     A+ +  ++  ++  L+       +E+   + ++AE   QL  E++
Sbjct: 961  EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020

Query: 686  KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS 745
            KA    ++  +++ +   L+   +  + T+  LE+ KR+      + Q  I+EL+A+   
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080

Query: 746  LVEQHKRERKELEEERAGRKGLEARLQQLGEAH-----QAETEVLRRELAEAMAAQHTAE 800
            L  Q  ++ +EL+   A  +G +  L +          QA+   L+ +     A+++ AE
Sbjct: 1081 LKLQLAKKEEELQGALA--RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138

Query: 801  SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
             +   L +E+ A +   ED+    A      Q++L T +E      QE+ E K+ +    
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAA-----QQELRTKRE------QEVAELKKALEEET 1187

Query: 861  SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
             + E QI   +   A     L+  L+Q +  +   +K    L T  +++A   K + +++
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK 1247

Query: 921  TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR---QFCSTQAALQAMEREAEQM 977
                   ++ +   +EL  + +  GDR    L E+  +   +  +    L+  E++  + 
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSE-GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306

Query: 978  GNELERLRAALMESQGQQQEERGQQ---EREVARLTQERGRAQADLALEKAARAELEMRL 1034
              +   L + L ++Q   QEE  Q+      + +L +E+   Q     E+ AR  LE ++
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366

Query: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
                         LQ  LA     K+  D +L  +  LE A+ K L++     ++L+E+ 
Sbjct: 1367 -----------LALQSQLADT---KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412

Query: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154
               +K   + +  Q E    T      L+  R   S LE++ QK+ +Q  + E+S+ A  
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVD----LDHQRQVASNLEKK-QKKFDQLLAEEKSISARY 1467

Query: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214
            A   ERD A E    + E KA  L  +      A+ E    R   Q  +  ED   ++  
Sbjct: 1468 AE--ERDRA-EAEAREKETKALSLARALEEALEAKEEFE--RQNKQLRADMEDLMSSKDD 1522

Query: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQA 1274
             G+         +  LE+    L +QV E   + +EL+  + A  +   +LE  ++ ++A
Sbjct: 1523 VGKN--------VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 1275 ETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQE 1334
            +         ER    R+E     +  EK+R+  + +R+    +AE  +E  Q   A   
Sbjct: 1575 QF--------ERDLQTRDE-----QNEEKKRLLIKQVRE---LEAELEDERKQRALAVAS 1618

Query: 1335 KFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGG 1394
            K  + E  L  L+ +  +      E++  K L ++LQA+     K ++ ELE+++ +   
Sbjct: 1619 KK-KMEIDLKDLEAQIEAANKARDEVI--KQL-RKLQAQM----KDYQRELEEARASRDE 1670

Query: 1395 LRAELLRAQREL----GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
            + A+   ++++L     E++ L++++A  ER  +    E+   A++++        L +E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730

Query: 1451 NRGLGERANLGRQFLEVEL-------DQAREKYVQ------ELAAVRADAETRLAEVQRE 1497
             R L  R     + LE E        D+ R+  +Q      ELAA R+ A+ +    +++
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ-KSDNARQQ 1789

Query: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557
             +   +EL+    + EGA       + +F+     L A++ QLE       +Q+E+ +K+
Sbjct: 1790 LERQNKELKAKLQELEGAV------KSKFKATISALEAKIGQLE-------EQLEQEAKE 1836

Query: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617
             A +++  +  ++KLK                     E+  Q+  + + A+ YK QMEKA
Sbjct: 1837 RAAANKLVRRTEKKLK---------------------EIFMQVEDERRHADQYKEQMEKA 1875

Query: 1618 KTHYDAKKQQNQELQEQL-----------RSLEQLQKENKELRAEAERLGHELQQAG-LK 1665
                   K+Q +E +E+            R L+   + N+ L  E   L + L++ G + 
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPIS 1935

Query: 1666 TKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQ 1701
               +    R L  +  SLE      + +  D+ + Q
Sbjct: 1936 FSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971



 Score =  202 bits (515), Expect = 2e-51
 Identities = 246/1132 (21%), Positives = 505/1132 (44%), Gaps = 150/1132 (13%)

Query: 276  KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR------- 328
            ++ EEL+ K+E L     +  K    ++ E  +M+RK  QL EE   L+ +L+       
Sbjct: 849  RQEEELQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904

Query: 329  -------EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381
                     A+  Q+L++ L++L              ++++E+E           EE+N+
Sbjct: 905  EAEEMRARLAAKKQELEEILHDL--------------ESRVEEE-----------EERNQ 939

Query: 382  ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLET 441
            ILQ +  +++ H+  L++   +E+G         + L+ E  T  A   +++  + +LE 
Sbjct: 940  ILQNEKKKMQAHIQDLEEQLDEEEG-------ARQKLQLEKVTAEAKIKKMEEEILLLED 992

Query: 442  ERGQ--QEAKLLAER-----GHFEEEKQQLSSL----------ITDLQSSISNLSQAKEE 484
            +  +  +E KL+ +R         EE+++  +L          I+DL+  +    + ++E
Sbjct: 993  QNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE 1052

Query: 485  LEQASQ---AHGARLTAQVASLTSELTTLNATIQQQDQELAGL----KQQAKEKQAQLAQ 537
            LE+A +        L  Q+A L +++  L   + ++++EL G       +   K   L  
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112

Query: 538  TLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597
              + Q Q ++ L+   E   +S  + E+Q ++++E+ EA + +    L T A ++E   +
Sbjct: 1113 VRELQAQIAE-LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK 1171

Query: 598  ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ- 656
                  +  +ALE+E       +Q   Q    A +     + QA+R KA L +  + L+ 
Sbjct: 1172 REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231

Query: 657  -----AC-VETARQEQHEAQAQVAELELQLRSEQQKATEKER----VAQEKDQLQEQL-- 704
                 AC V+  +Q + E++ +  +L+ Q++    K +E +R    +A++  +LQ +L  
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN 1291

Query: 705  ------QALKESLKVTK--GSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756
                  +A K+ +K  K   SLE + +   + L+E+ R    L +  R L E+    +++
Sbjct: 1292 VSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351

Query: 757  LEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
             EEE   RK LE ++  L    Q++    ++++ + +    + E   ++L+K+  A  +R
Sbjct: 1352 QEEEEEARKNLEKQVLAL----QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407

Query: 817  YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL--QISRQQNEL 874
             E    E+A      ++    L++E +    +L   ++  + +E   +   Q+  ++  +
Sbjct: 1408 LE----EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 875  AELHA-NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
            +  +A    RA  + +EKE +A  LA     L+E + A  KE    +    +A  +   +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLA---RALEEALEA--KEEFERQNKQLRADMEDLMS 1518

Query: 934  SRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 993
            S++ V +     ++    LE+Q           ++ M  + E++ +EL+    A +  + 
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQ-----------VEEMRTQLEELEDELQATEDAKLRLEV 1567

Query: 994  QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
              Q  + Q ER++   T++    +    L K  R ELE  L++   ++           A
Sbjct: 1568 NMQAMKAQFERDLQ--TRDEQNEEKKRLLIKQVR-ELEAELEDERKQR-----------A 1613

Query: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
             A+  K+  + +L  L     A  K  +E+ + +++L+ Q+   ++E      ++ E   
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 1114 RTEPTGPKLEALRAEVSKLEQQ---CQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
            +++ +  KL++L AE+ +L+++    ++ +  A+     L  E  + A   SAL   + +
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733

Query: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSL 1230
            LE +  +L   +  L   Q  +     + +  +   D   A++A  R  A++ ++    L
Sbjct: 1734 LEARIAQL---EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790

Query: 1231 EEEVSILNRQVLEKEGESK-ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSA 1289
            E +   L  ++ E EG  K + K  + A   K  +LEE+L     E A+ +         
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850

Query: 1290 LRE---EVQSLREEAE--KQRVASENLR-QELTSQAERAEELGQELKAWQEK 1335
            L+E   +V+  R  A+  K+++   N R ++L  Q E AEE      A + K
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK 1902



 Score =  171 bits (433), Expect = 7e-42
 Identities = 251/1043 (24%), Positives = 438/1043 (41%), Gaps = 164/1043 (15%)

Query: 779  QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTL 838
            + E +    EL +    Q   E E E++        ER      EE    A   +    L
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEM--------ERKHQQLLEEKNILAEQLQAETEL 902

Query: 839  KEECEKARQEL----QEAKEKVAGIESHSELQISRQQ---NELAELHANLARALQQVQEK 891
              E E+ R  L    QE +E +  +ES  E +  R Q   NE  ++ A++    +Q+ E+
Sbjct: 903  FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962

Query: 892  EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
            E   QKL  +  T + K+    +E+  LE             + + +KE     DR  E 
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLED-----------QNSKFIKEKKLMEDRIAE- 1010

Query: 952  LEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQ 1011
                     CS+Q A      E E+    L ++R    E      EER ++E +     Q
Sbjct: 1011 ---------CSSQLA------EEEEKAKNLAKIRNK-QEVMISDLEERLKKEEKTR---Q 1051

Query: 1012 ERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG 1071
            E  +A+  L  E     +    LQ  ++E +++ A  +E L  AL    G D+ L K   
Sbjct: 1052 ELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR--GDDETLHKNNA 1109

Query: 1072 LEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV-- 1129
            L+             V++L+ Q+A+ +++  S   ++++A  +      +LEAL+ E+  
Sbjct: 1110 LKV------------VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157

Query: 1130 ------SKLEQQCQKQQEQADSLERSLEAERAS--------RAERDSALETLQGQLEEKA 1175
                  ++ E + +++QE A+ L+++LE E  +        R    +ALE L  QLE+  
Sbjct: 1158 TLDTTAAQQELRTKREQEVAE-LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 1176 Q---ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK-----AQVARGRQEAERKNSLI 1227
            +    L  ++  L +  +ELA    KV    KAE E K     AQV     +    + L 
Sbjct: 1217 RFKANLEKNKQGLETDNKELAC-EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275

Query: 1228 SSLEEEVSILNRQV-----LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR 1282
              L E+ S L  ++     L +E E K +K    A S +SQ L++   LLQ ET      
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ-LQDTQELLQEETRQK-LN 1333

Query: 1283 AAERSSALREEVQSLREEAEKQRVASENL-RQELTSQAERAE-------ELG--QELKAW 1332
             + R   L EE  SL+E+ E++  A +NL +Q L  Q++ A+       +LG  + L+  
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393

Query: 1333 QEKFFQKEQALS---------------------------TLQLEHTSTQALVSELLPAKH 1365
            ++K  +  +ALS                           T+ L+H   + + S L   + 
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ--RQVASNLEKKQK 1451

Query: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
               QL AE+ +   R+ EE ++++  A     + L   R L E +  ++   E ER  +Q
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE---EFERQNKQ 1508

Query: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ------AREKYVQE 1479
            LRA+          + K    L +  R L ++    R  LE   D+      A+ +    
Sbjct: 1509 LRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN 1568

Query: 1480 LAAVRADAETRLA-------EVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK 1532
            + A++A  E  L        E +R      RELE         +   +  +++ + + + 
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628

Query: 1533 LTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592
            L AQ+E     + E  KQ+ +L  ++ D  +  +  +     + AQ  ES+++ + L+A+
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688

Query: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648
            + +LQ +L+  E+A  H + + ++              L ++ R LE    QL++E +E 
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748

Query: 1649 RAEAERLGHELQQAGLK--TKEAEQTCRHLTAQV-----RSLEAQVAHADQQLRDL---- 1697
            ++  E L    ++  L+  T  AE       AQ      + LE Q      +L++L    
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 1698 -GKFQVATDALKSREPQAKPQLD 1719
              KF+    AL+++  Q + QL+
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLE 1831



 Score =  152 bits (384), Expect = 3e-36
 Identities = 180/788 (22%), Positives = 347/788 (44%), Gaps = 63/788 (7%)

Query: 162  STFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKK 221
            +T  EELS    QAKR    LE  K    +                +LQ  + +    +K
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK------VLQQVKAESEHKRK 1255

Query: 222  QLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEEL 281
            +L    +   EL  +++E  +L  E   + + +Q  +D ++ L E+      E K ++  
Sbjct: 1256 KLD---AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA-----EKKGIKFA 1307

Query: 282  RDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQD-- 339
            +D   SL  +L +T +  Q+   +K  +  +I QL EE   L  +  E     + L+   
Sbjct: 1308 KDA-ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366

Query: 340  -ALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
             AL     +  K   + L     LE+     L+D + L ++ E       +LE+  ++LQ
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426

Query: 399  DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
                QE  ++  D+            +A+N  + Q + + L  E     A+   ER   E
Sbjct: 1427 ----QELDDLTVDL-------DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 459  EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
             E ++  +    L  ++    +AKEE E+ ++    +L A +  L S    +   + + +
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNK----QLRADMEDLMSSKDDVGKNVHELE 1531

Query: 519  QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK-QKEQQLKEVAEKQEAT 577
            +    L+QQ +E + QL + L+ + QA++  + ++E    ++K Q E+ L+   E+ E  
Sbjct: 1532 KSKRALEQQVEEMRTQLEE-LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590

Query: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637
            ++   +Q+     E E   ++R  A+    A +K+    L+ L+ Q++ AN+ARD     
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAV----ASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646

Query: 638  VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK 697
            + + Q +  +  R++EE +A  +    +  E++ ++  LE ++   Q++    ER  +  
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706

Query: 698  DQLQEQLQALKESLKVTKGSLEEEKRR-------AADALEEQQRCISELKAETRSLVEQH 750
            +Q +++L     +    K +L +EKRR         + LEE+Q  +  L    R    Q 
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766

Query: 751  KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEV 810
                 EL  ER+  +  +   QQL E    E +   +EL  A+ ++  A      L  ++
Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQL-ERQNKELKAKLQELEGAVKSKFKA--TISALEAKI 1823

Query: 811  AAWRERYEDSQQEEAQYGAMFQEQLMTLKE---ECEKARQELQEAKEKVAGIESHSELQI 867
                E+ E   +E A    + +     LKE   + E  R+   + KE++   ++++ ++ 
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME--KANARMKQ 1881

Query: 868  SRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG 927
             ++Q E AE  A  A A ++  ++E+      DD +   E +   S+EV+ L+  +R+ G
Sbjct: 1882 LKRQLEEAEEEATRANASRRKLQREL------DDATEANEGL---SREVSTLKNRLRRGG 1932

Query: 928  EQQETASR 935
                ++SR
Sbjct: 1933 PISFSSSR 1940



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 48/225 (21%), Positives = 104/225 (46%), Gaps = 17/225 (7%)

Query: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK---QVEELSKKLADSDQASKVQQQKL 1572
            KVK L +  R +EE Q   A+ E+L   + +QTK   ++EE+ +K     +   +  ++L
Sbjct: 840  KVKPLLQVTRQEEELQ---AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896

Query: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
            +A      E+++   RL A+  EL+  L   E   E  + + +  +      +   Q+L+
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956

Query: 1633 EQLRSLE----QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
            EQL   E    +LQ E     A+ +++  E+     +  +  +  + +  ++    +Q+A
Sbjct: 957  EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016

Query: 1689 HADQQLRDLGKFQVATDALKS-------REPQAKPQLDLSIDSLD 1726
              +++ ++L K +   + + S       +E + + +L+ +   LD
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  203 bits (516), Expect = 2e-51
 Identities = 258/1159 (22%), Positives = 519/1159 (44%), Gaps = 138/1159 (11%)

Query: 242  KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQ--- 298
            K L +   Q   M  + + L  + EKQ A+     E+E L+ +  +  ++L E L+    
Sbjct: 835  KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 299  -CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ----------DALNELTEE 347
             C + +  ++++  K  +L E   DL  ++ E     Q LQ            L E  EE
Sbjct: 895  LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 348  HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGE 407
               A Q+   ++   E +L    +++  LE++N  L  +   LE+ +++   N  +E   
Sbjct: 955  EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE--- 1011

Query: 408  VLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSL 467
                       ++++ +LA    + +A +  LE ER ++E K   +R   E+ +++L   
Sbjct: 1012 -----------EEKSKSLAKLKNKHEAMITDLE-ERLRREEK---QRQELEKTRRKLEGD 1056

Query: 468  ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527
             TDL   I                  A L AQ+A L  +L      +Q     LA ++++
Sbjct: 1057 STDLSDQI------------------AELQAQIAELKMQLAKKEEELQ---AALARVEEE 1095

Query: 528  AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQL-A 586
            A +K   L +  + + Q S+ L+  +E   +S  + E+Q +++ E+ EA + +    L +
Sbjct: 1096 AAQKNMALKKIRELESQISE-LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS 1154

Query: 587  TAAEEREASLRERDAAL--KQLEALEKEKAAKLEILQQQLQVANE--ARDSAQTSVTQAQ 642
            TAA++   S RE++  +  K LE   K   A+++ ++Q+   A E  A    QT   +A 
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214

Query: 643  REKAE--LSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERV----AQE 696
             EKA+  L  +  EL   V+   Q + +++ +  ++E QL+  Q K  E ERV    A +
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274

Query: 697  KDQLQEQL--------QALKESLKVTK--GSLEEEKRRAADALEEQQRCISELKAETRSL 746
              +LQ +L        Q+  +S K+TK   +LE + +   + L+E+ R    L  + + +
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV 1334

Query: 747  VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL 806
             ++    R++LEEE   +  LE ++  L     A+   +++++ +++    TAE    +L
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATL----HAQVADMKKKMEDSVGCLETAEEVKRKL 1390

Query: 807  VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL- 865
             K++    +R+E   ++ A Y  + ++    L++E +    +L   ++    +E   +  
Sbjct: 1391 QKDLEGLSQRHE---EKVAAYDKL-EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF 1446

Query: 866  -QISRQQNELAELHA-NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
             Q+  ++  ++  +A    RA  + +EKE +A  LA  L    E+ A   +   +  T +
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506

Query: 924  RKAGEQQETASREL--VKEPARAGDRQPEWLE---EQQGRQFCSTQAALQAMEREAEQMG 978
                  ++   + +  +++  RA ++Q E ++   E+   +  +T+ A   +E   + M 
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566

Query: 979  NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
             + ER    L     Q +E++ Q  R+V  +  E    +   ++  AAR +LEM      
Sbjct: 1567 AQFER---DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM------ 1617

Query: 1039 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098
                     L++  AH  +  + +D+ + +LR L+A     + EL  T    +E LA+ +
Sbjct: 1618 --------DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669

Query: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158
            +        ++E     E      E   AE +K + Q Q++ E AD +  S   + A   
Sbjct: 1670 ENEKKLKSMEAEMIQLQE------ELAAAERAKRQAQ-QERDELADEIANS-SGKGALAL 1721

Query: 1159 ERDSALETLQGQLEEK-AQELGHSQ---SALASAQRELAAFRTKV---QDHSKAEDEWKA 1211
            E    LE    QLEE+  +E G+++     L  A  ++    T +   + H++  +  + 
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ 1781

Query: 1212 QVARGRQE-----AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266
            Q+ R  +E      E + ++ S  +  ++ L  ++ + E +     +   A  ++ ++ E
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841

Query: 1267 ERLR--LLQAETASNSA--------RAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316
            ++L+  LLQ +    +A        +A+ R   L+ +++   EEA++   +   L++EL 
Sbjct: 1842 KKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901

Query: 1317 SQAERAEELGQELKAWQEK 1335
               E A+ + +E+ + + K
Sbjct: 1902 DATETADAMNREVSSLKNK 1920



 Score =  198 bits (504), Expect = 4e-50
 Identities = 248/1128 (21%), Positives = 489/1128 (43%), Gaps = 128/1128 (11%)

Query: 415  LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS 474
            L+  +QE   +A     ++ R + L  E    E + L  +     EK QL   +      
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETL--QSQLMAEKLQLQEQL------ 889

Query: 475  ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA- 533
                 QA+ EL   ++   ARLTA+   L      L A ++++++    L+ + K+ Q  
Sbjct: 890  -----QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQN 944

Query: 534  --QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
              +L + L+++E A Q L+ +     + LK+ E++ + + E Q        + L     E
Sbjct: 945  IQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE-QIILEDQNCKLAKEKKLLEDRIAE 1003

Query: 592  REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
               +L E +   K L  L+ +  A +  L+++L+   + R   + +  + + +  +LS +
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063

Query: 652  VEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL 711
            + ELQA +   + +  + +    EL+  L   +++A +K    ++  +L+ Q+  L+E L
Sbjct: 1064 IAELQAQIAELKMQLAKKE---EELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 712  KVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH----KRE------RKELEEER 761
            +  + S  + +++  D  EE +   +EL+    S   Q     KRE      +K LEEE 
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE- 1179

Query: 762  AGRKGLEARLQQLGEAHQAETEVLRREL-------AEAMAAQHTAESECEQLVKEVAAWR 814
               K  EA++Q++ + H    E L  +L       A    A+ T E+E  +L  EV    
Sbjct: 1180 --AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237

Query: 815  ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE-------LQEAKEKVAGIESHSELQI 867
            +   DS+ +  +  A  QE L     E E+ R E       LQ   + V G+ S S+ + 
Sbjct: 1238 QGKGDSEHKRKKVEAQLQE-LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296

Query: 868  SRQQNELAELHANLARALQQVQEK-------EVRAQKLADDLSTLQEKMAA-------TS 913
            S+   + + L + L    + +QE+         + +++ D+ ++ +E++           
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356

Query: 914  KEVARLETLVRKAGEQQE--TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAME 971
            K++A L   V    ++ E      E  +E  R   +  E L ++   +     AA   +E
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV----AAYDKLE 1412

Query: 972  REAEQMGNEL---------ERLRAALMESQGQQQEERGQQEREV-ARLTQERGRAQADLA 1021
            +   ++  EL         +R  A  +E + ++ ++   +E+ + A+  +ER RA+A+ A
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE-A 1471

Query: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
             EK  +A   + L  AL E   + A L+       TE E    +L   +      + ELE
Sbjct: 1472 REKETKA---LSLARALEEAMEQKAELERLNKQFRTEME----DLMSSKDDVGKSVHELE 1524

Query: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
            + ++ ++Q  E++  + +E      A  +A  R E     L+A++A+  +  Q   +Q E
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE---VNLQAMKAQFERDLQGRDEQSE 1581

Query: 1142 --------QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
                    Q   +E  LE ER  R+   +A + L+  L++    +  +      A ++L 
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641

Query: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
              + +++D  +  D+ +A       +A+     + S+E E+  L  +             
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE------------- 1688

Query: 1254 LVMAESEKSQKLEERLRLLQ--AETASNSARAAERSSALREEVQSLREEAEKQRVASENL 1311
            L  AE  K Q  +ER  L    A ++   A A E    L   +  L EE E+++  +E +
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI 1748

Query: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL---LPAKHLCQ 1368
               L     + +++  +L   +    + E A   L+ ++   +  + E+   + +K+   
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808

Query: 1369 --QLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQL 1426
               L+A+ A  E++   E ++ + A   +R    R +++L +++    +V ++ R A+Q 
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVR----RTEKKLKDVL---LQVDDERRNAEQY 1861

Query: 1427 RAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474
            + +    + +L  LK+      EE     +RAN  R+ L+ EL+ A E
Sbjct: 1862 KDQADKASTRLKQLKRQ----LEEAEEEAQRANASRRKLQRELEDATE 1905



 Score =  192 bits (489), Expect = 2e-48
 Identities = 250/1173 (21%), Positives = 506/1173 (43%), Gaps = 148/1173 (12%)

Query: 552  QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611
            QV +    +  KE++L +V EKQ             AAE R          L ++E L+ 
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQ------------LAAENR----------LTEMETLQS 876

Query: 612  EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671
            +  A+   LQ+QLQ   E          +A+  +A L+ K +EL+           E + 
Sbjct: 877  QLMAEKLQLQEQLQAETEL-------CAEAEELRARLTAKKQELEEICHDLEARVEEEEE 929

Query: 672  QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE 731
            +   L+ + +  QQ   E E   +E++  +++LQ  K + +     LEEE+      + E
Sbjct: 930  RCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQ-----IILE 984

Query: 732  QQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEV-LRRELA 790
             Q C  +L  E + L ++       L EE    K L A+L+   EA   + E  LRRE  
Sbjct: 985  DQNC--KLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-AKLKNKHEAMITDLEERLRRE-- 1039

Query: 791  EAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850
                         E+  +E+   R + E    + +   A  Q Q+  LK +  K  +ELQ
Sbjct: 1040 -------------EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086

Query: 851  EAKEKV---AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907
             A  +V   A  ++ +  +I   +++++EL  +L        + E + + L ++L  L+ 
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146

Query: 908  KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967
            ++  T    A  + L R   EQ+    ++ ++E A+  + Q + + ++            
Sbjct: 1147 ELEDTLDSTAAQQEL-RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS---------- 1195

Query: 968  QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
            QA+E  AEQ+  + +R++A L +++   + ERG+   EV  L Q +G ++      +A  
Sbjct: 1196 QAVEELAEQL-EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 1028 AELEM------RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
             EL++      R++  L ++  +     + +   L++ + K  +L K      +Q+++ +
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314

Query: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE----ALRAEVSKLEQQCQ 1137
            EL Q   + K  L+ K K+      +  E     E     LE     L A+V+ ++++ +
Sbjct: 1315 ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME 1374

Query: 1138 KQQ---EQADSLERSLEAERASRAER-----------DSALETLQGQLEEKAQELGHSQS 1183
                  E A+ ++R L+ +    ++R           +     LQ +L++   +L H + 
Sbjct: 1375 DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434

Query: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
            +  + +++   F   + +      ++  +  R   EA  K +   SL   +     + +E
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE----EAME 1490

Query: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303
            ++ E + L +    E E     ++ +     E    S RA E+     EE+++  EE E 
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL-EKSKRALEQQV---EEMKTQLEELED 1546

Query: 1304 QRVASEN--LRQELTSQAERAEELGQELKAWQEKFFQKEQAL--------STLQLEHTST 1353
            +  A+E+  LR E+  QA +A+   ++L+   E+  +K++ L        + L+ E    
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQ-FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605

Query: 1354 QALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
               V+     +   + L+A   +A K   E ++Q ++    L+A++    REL +    R
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK----LQAQMKDCMRELDDTRASR 1661

Query: 1414 QKVA----EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469
            +++     E E+  + + AE     E+L+  ++A     +E   L +          + L
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721

Query: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE-------- 1521
            ++ R              E R+A+++ E +      E++  + + A +++ +        
Sbjct: 1722 EEKRR------------LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769

Query: 1522 --ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ-QQKLKAVQAQ 1578
                Q+ +  RQ+L  Q ++L+V  +E    V+   K    + +A   Q +++L     +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829

Query: 1579 GGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR-- 1636
               + ++ +R + +L ++  Q+  + + AE YK Q +KA T     K+Q +E +E+ +  
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889

Query: 1637 --SLEQLQKENKELRAEAERLGHELQQAGLKTK 1667
              S  +LQ+E ++    A+ +  E+  + LK K
Sbjct: 1890 NASRRKLQRELEDATETADAMNREV--SSLKNK 1920



 Score =  185 bits (469), Expect = 5e-46
 Identities = 243/1052 (23%), Positives = 459/1052 (43%), Gaps = 110/1052 (10%)

Query: 213  QFQMRRLKKQLADERSNRDELELE----------LAENRKLLTEKDAQIAMMQQRI-DRL 261
            Q  ++ L++QL +E S R +L+LE          L E + +L +++ ++A  ++ + DR+
Sbjct: 942  QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001

Query: 262  ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321
            A           + K L +L++K+E++   L E L++ +  + E  +  RK   L  ++ 
Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK---LEGDST 1058

Query: 322  DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381
            DLS ++ E       LQ  + EL  + +K  +E     A++E+E   A Q    L++  E
Sbjct: 1059 DLSDQIAE-------LQAQIAELKMQLAKKEEELQAALARVEEE---AAQKNMALKKIRE 1108

Query: 382  ILQGKLSQLEEHLS--QLQDNPPQEKGEVLGDVLQ-LETLKQEAATLAANNTQLQARVEM 438
             L+ ++S+L+E L   +   N  +++   LG+ L+ L+T  ++     A   +L+++ E 
Sbjct: 1109 -LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167

Query: 439  ---LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGAR 495
               +  +  ++EAK        +E +Q+ S  + +L   +    + K  LE+A Q     
Sbjct: 1168 EVNILKKTLEEEAK--THEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT---- 1221

Query: 496  LTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ 555
            L  +   L +E+  L       + +   ++ Q +E Q +      + E+    L  +V +
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKF----NEGERVRTELADKVTK 1277

Query: 556  LSSSLKQKEQQLKEVAEKQEATRQDHA---QQLATAAEEREASLRERDAALKQLEALEKE 612
            L   L      L +   K     +D +    QL    E  +   R++ +   +L+ +E E
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337

Query: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
            K +     ++QL+   EA+ + +  +     + A++ +K+E+   C+ETA + + + Q  
Sbjct: 1338 KNS----FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK- 1392

Query: 673  VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL--EEEKRRAADALE 730
              +LE   +  ++K    +++ + K +LQ++L  L   L   + S    E+K++  D L 
Sbjct: 1393 --DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450

Query: 731  EQQRCISELKAETRSLVEQHKRER--KELEEERAGRKGLE--ARLQQLGEAHQAETEVLR 786
             +++ IS   AE R   E   RE+  K L   RA  + +E  A L++L +  + E E L 
Sbjct: 1451 AEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510

Query: 787  RELAEAMAAQHTAESE---CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
                +   + H  E      EQ V+E+    E  ED  Q         +  L  +K + E
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570

Query: 844  KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
            +  Q   E  E+        + Q+ RQ   + E+ A L    +Q        +KL  DL 
Sbjct: 1571 RDLQGRDEQSEE-------KKKQLVRQ---VREMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 904  TLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963
             L+  + + +K        +RK   Q +   REL  +  RA         E+   Q    
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL--DDTRAS-------REEILAQAKEN 1671

Query: 964  QAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE 1023
            +  L++ME E  Q+  EL    AA   ++ Q Q+ER +   E+A  +      +  LALE
Sbjct: 1672 EKKLKSMEAEMIQLQEEL----AAAERAKRQAQQERDELADEIANSS-----GKGALALE 1722

Query: 1024 KAARAELEM-RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082
            +  R E  + +L+  L E++     + + L  A  + +  + +L   R          ++
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782

Query: 1083 LRQTVKQLKEQLAK-----KEKEHASGSGAQSEAAGRTEPTGPKLEALRA---EVSKLEQ 1134
            L +  K+LK +L +     K K  AS +  +++ A   E    + +  +A   +V + E+
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842

Query: 1135 QCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA 1194
            + +    Q D   R+ E  +    +  + L+ L+ QLEE  +E   + ++    QREL  
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL-- 1900

Query: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
                       ED  +   A  R+ +  KN L
Sbjct: 1901 -----------EDATETADAMNREVSSLKNKL 1921



 Score =  179 bits (454), Expect = 3e-44
 Identities = 234/1112 (21%), Positives = 482/1112 (43%), Gaps = 121/1112 (10%)

Query: 678  LQLRSEQ--QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRC 735
            L+LR+ Q  +  T+ + + Q   Q +E +   +E +KV +  L  E R     L E +  
Sbjct: 820  LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENR-----LTEMETL 874

Query: 736  ISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE-AHQAETEVLRRE------ 788
             S+L AE   L EQ + E +   E    R  L A+ Q+L E  H  E  V   E      
Sbjct: 875  QSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934

Query: 789  LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
             AE    Q   +   EQL +E +A ++   +    EA+   + +EQ++   + C+ A+++
Sbjct: 935  QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994

Query: 849  LQEAKEKVAGI------ESHSELQISRQQNE----LAELHANLARALQQVQEKEVRAQKL 898
             +  ++++A        E      +++ +N+    + +L   L R  +Q QE E   +KL
Sbjct: 995  -KLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053

Query: 899  ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD-----RQPEWLE 953
              D + L +++A    ++A L+  + K  E+ + A   + +E A+        R+ E   
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113

Query: 954  EQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL---MESQGQQQEERGQQEREVARLT 1010
             +      S +A+    E++   +G ELE L+  L   ++S   QQE R ++E+EV  L 
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173

Query: 1011 QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLR 1070
            +          LE+ A+       +  + E R + +   E LA          ++L + +
Sbjct: 1174 K---------TLEEEAKTH-----EAQIQEMRQKHSQAVEELA----------EQLEQTK 1209

Query: 1071 GLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
             ++A     LE+ +QT++  + +LA + K    G G       + E    +L+ L+ + +
Sbjct: 1210 RVKA----NLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA---QLQELQVKFN 1262

Query: 1131 KLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR 1190
            + E+   +  ++   L+  L+      ++ DS    L         +L  +Q  L    R
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322

Query: 1191 ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE 1250
            +  +  TK++     ++ ++ Q+    +E E K++L    E++++ L+ QV + + + ++
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQL---EEEEEAKHNL----EKQIATLHAQVADMKKKMED 1375

Query: 1251 LKRLVMAESEKSQKLEERLRLLQAETASNSA---RAAERSSALREEVQSLREEAEKQRVA 1307
                +    E  +KL++ L  L        A   +  +  + L++E+  L  + + QR +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435

Query: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367
            + NL ++     ++ ++L  E K    K+ + E+  +  +     T+AL   L  A    
Sbjct: 1436 ACNLEKK----QKKFDQLLAEEKTISAKYAE-ERDRAEAEAREKETKAL--SLARALEEA 1488

Query: 1368 QQLQAEQAAAEKRHREELEQ---SKQAAGGLRAELLRAQRELGELIP-LRQKVAEQERTA 1423
             + +AE     K+ R E+E    SK   G    EL +++R L + +  ++ ++ E E   
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548

Query: 1424 QQLRAEKASYAEQLSMLKKA--HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELA 1481
            Q     K      L  +K      L   + +   ++  L RQ  E+E +   E+  + +A
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608

Query: 1482 -AVRADAETRLAEVQREAQSTAR---ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537
             A R   E  L +++    S  +   E      K +      + E    +  R+++ AQ 
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA 1668

Query: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV-------QAQGGESQQEAQRLQ 1590
            ++ E   +    ++ +L ++LA +++A +  QQ+   +         +G  + +E +RL+
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728

Query: 1591 AQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ----QNQELQEQLRSLEQLQKENK 1646
            A++ +L+ +L +++   E    +++KA    D        +    Q+   + +QL+++NK
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788

Query: 1647 ELRAEAERLGHEL-------------------QQAGLKTKEAEQTCRHLTAQVRSLEAQV 1687
            EL+ + + +   +                   +Q   +TKE +  C+ +    + L+  +
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848

Query: 1688 AHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
               D + R+  +++   D   +R  Q K QL+
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQLE 1880



 Score =  158 bits (400), Expect = 5e-38
 Identities = 201/972 (20%), Positives = 430/972 (44%), Gaps = 126/972 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRID-RLALLNEK 267
            L+  + Q + L+K       +  +L  ++AE +  + E   Q+A  ++ +   LA + E+
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095

Query: 268  QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
             A   +  K++ EL  +   L           +DL++E++      N+  ++  DL  +L
Sbjct: 1096 AAQKNMALKKIRELESQISELQ----------EDLESERASR----NKAEKQKRDLGEEL 1141

Query: 328  REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
                + L+   D         S A Q+ L  + + E  +      KK LEE+ +  + ++
Sbjct: 1142 EALKTELEDTLD---------STAAQQELRSKREQEVNIL-----KKTLEEEAKTHEAQI 1187

Query: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE 447
             ++ +  SQ  +   ++  +       LE  KQ   TL     +L   V++L   +G  E
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ---TLENERGELANEVKVLLQGKGDSE 1244

Query: 448  AK----------LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
             K          L  +    E  + +L+  +T LQ  + N++     L   S +  ++LT
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT----GLLSQSDSKSSKLT 1300

Query: 498  AQVASLTSELTTLNATIQQQDQELAGLK---QQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
               ++L S+L      +Q+++++   L    +Q ++++    + L+++E+A   L  Q+ 
Sbjct: 1301 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360

Query: 555  QLSSSLKQKEQQLK------EVAEKQEATRQDHAQQLATAAEEREASL-----------R 597
             L + +   +++++      E AE+ +   Q   + L+   EE+ A+            +
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420

Query: 598  ERDAALKQLEALEKEKAAKLEILQQQLQ--VANEARDSAQTSVTQAQREKAELSRKVEEL 655
            E D  L  L+  +++ A  LE  Q++    +A E   SA+ +    +R++AE   + +E 
Sbjct: 1421 ELDDLLVDLDH-QRQSACNLEKKQKKFDQLLAEEKTISAKYA---EERDRAEAEAREKET 1476

Query: 656  QA-CVETARQEQHEAQAQVAELELQLRSEQQK-ATEKERVAQEKDQLQEQLQALKESLKV 713
            +A  +  A +E  E +A++  L  Q R+E +   + K+ V +   +L++  +AL++ ++ 
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536

Query: 714  TKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE---RKELEEERAGRKGLEAR 770
             K  LEE      D L+  +     L+   +++  Q +R+   R E  EE+  +K L  +
Sbjct: 1537 MKTQLEE----LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK--KKQLVRQ 1590

Query: 771  LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830
            ++++    +AE E  R++ + A+AA+   E + + L   + +  +  +++ ++  +  A 
Sbjct: 1591 VREM----EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646

Query: 831  FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
             ++ +  L +      + L +AKE        +E ++   + E+ +L   LA A +  ++
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKE--------NEKKLKSMEAEMIQLQEELAAAERAKRQ 1698

Query: 891  KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE--QQETASRELVKEPARAGDRQ 948
             +    +LAD+++    K A   +E  RLE  + +  E  ++E  + EL+ +  +  + Q
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758

Query: 949  PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008
             + +      +    ++  Q  E   +Q+  + + L+  L E +G               
Sbjct: 1759 IDQINTDLNLE----RSHAQKNENARQQLERQNKELKVKLQEMEG--------------- 1799

Query: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQEL-A 1067
                + + +A +   +A  A+LE +L N   E++     ++       TEK+ KD  L  
Sbjct: 1800 --TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRR------TEKKLKDVLLQV 1851

Query: 1068 KLRGLEAAQIKELEELRQT-VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126
                  A Q K+  +   T +KQLK QL + E+E    + ++ +     E      +A+ 
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911

Query: 1127 AEVSKLEQQCQK 1138
             EVS L+ + ++
Sbjct: 1912 REVSSLKNKLRR 1923



 Score =  137 bits (345), Expect = 1e-31
 Identities = 210/892 (23%), Positives = 376/892 (42%), Gaps = 132/892 (14%)

Query: 922  LVRKA--GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGN 979
            L RKA    QQ+  + ++++    A  +   W   Q  R F   +  LQ   +E E M  
Sbjct: 794  LARKAFAKRQQQLTAMKVLQRNCAAYLKLRNW---QWWRLFTKVKPLLQVSRQEEEMMAK 850

Query: 980  E-------------------LERLRAALMESQGQQQEERGQQEREV--------ARLTQE 1012
            E                   +E L++ LM  + Q QE+  Q E E+        ARLT +
Sbjct: 851  EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL-QAETELCAEAEELRARLTAK 909

Query: 1013 RGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072
            +   +      +A   E E R Q+   E++     +QE L   L E+E   Q+L   +  
Sbjct: 910  KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE-LEEQLEEEESARQKLQLEKVT 968

Query: 1073 EAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
              A++K+LEE +  ++    +LAK++K         +      E     L  L+      
Sbjct: 969  TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK------ 1022

Query: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192
                 K +     LE  L  E   R E +     L+G   + + ++   Q+ +A  + +L
Sbjct: 1023 ----NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078

Query: 1193 AAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
            A          K E+E +A +AR  +EA +KN  +  + E    L  Q+ E + E  E +
Sbjct: 1079 A----------KKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQ-EDLESE 1123

Query: 1253 RLVMAESEKSQK-LEERLRLLQAE---TASNSARAAERSSALREEVQSLREEAEKQRVAS 1308
            R    ++EK ++ L E L  L+ E   T  ++A   E  S   +EV  L++  E++    
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH 1183

Query: 1309 ENLRQELTSQAERA-EELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367
            E   QE+  +  +A EEL ++L+  +      E+A  TL+ E       V  LL  K   
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243

Query: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427
            +  + +  A  +  + +  + ++    L  ++ + Q EL  +  L   +++ +  + +L 
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL---LSQSDSKSSKLT 1300

Query: 1428 AEKASYAEQLSMLKKAHGLLAEENRG----------LGERANLGRQFLEVELDQAR--EK 1475
             + ++   QL   ++   LL EENR           + +  N  R+ LE E +     EK
Sbjct: 1301 KDFSALESQLQDTQE---LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357

Query: 1476 YVQELAAVRADAETRLA----------EVQREAQSTARELEVMTAKYE---GAKVKVLEE 1522
             +  L A  AD + ++           EV+R+ Q   ++LE ++ ++E    A  K+ + 
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ---KDLEGLSQRHEEKVAAYDKLEKT 1414

Query: 1523 RQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK----LADSDQASKVQQQKLKAVQAQ 1578
            + R Q+E   L   ++     QR+    +E+  KK    LA+    S    ++    +A+
Sbjct: 1415 KTRLQQELDDLLVDLDH----QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470

Query: 1579 GGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL 1638
              E + +A  L   L E   Q ++ E+  + ++ +ME   +  D   +   EL++  R+L
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530

Query: 1639 EQLQKENK--------ELRA-EAERLGHELQQAGLKT----------KEAEQTCRHLTAQ 1679
            EQ  +E K        EL+A E  +L  E+    +K           +++E+  + L  Q
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590

Query: 1680 VRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEE 1731
            VR +EA++    +Q        +A  A K  E   K  L+  IDS + + +E
Sbjct: 1591 VREMEAELEDERKQR------SMAVAARKKLEMDLK-DLEAHIDSANKNRDE 1635



 Score =  133 bits (334), Expect = 2e-30
 Identities = 195/916 (21%), Positives = 389/916 (42%), Gaps = 85/916 (9%)

Query: 47   EEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHS 106
            E  Q+ +       L+   S LQ++ +   +       QK   G ELE  K  +     S
Sbjct: 1095 EAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS 1154

Query: 107  TMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPE 166
            T + +  R   + E  I       LK  L+ E+       ++   QK        S   E
Sbjct: 1155 TAAQQELRSKREQEVNI-------LKKTLE-EEAKTHEAQIQEMRQK-------HSQAVE 1199

Query: 167  ELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADE 226
            EL+    Q KR    LE  K    +       G  A+ +  +LQ       + KK  A  
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENE-----RGELANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 227  RSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQAASPLEPKELEELRDKN 285
            +    EL+++  E  ++ TE   ++  +Q  +D +  LL++  + S    K+   L  + 
Sbjct: 1255 Q----ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ- 1309

Query: 286  ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345
                  L +T +  Q+   +K  +  K+ Q+ +E      +L E       L+  +  L 
Sbjct: 1310 ------LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363

Query: 346  EEHSKATQEWLEKQAQLE--KELSAALQ-DKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402
             + +   ++  +    LE  +E+   LQ D + L +++E       +LE+  ++LQ    
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ---- 1419

Query: 403  QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 462
            QE  ++L D   L+  +Q A  L       Q + + L  E     AK   ER   E E +
Sbjct: 1420 QELDDLLVD---LDHQRQSACNLEKK----QKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472

Query: 463  QLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA 522
            +  +    L  ++    + K ELE+ ++    +   ++  L S    +  ++ + ++   
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNK----QFRTEMEDLMSSKDDVGKSVHELEKSKR 1528

Query: 523  GLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK-QKEQQLKEVAEKQEATRQDH 581
             L+QQ +E + QL + L+ + QA++  + ++E    ++K Q E+ L+   E+ E  ++  
Sbjct: 1529 ALEQQVEEMKTQLEE-LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587

Query: 582  AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641
             +Q+     E E   ++R  A+   + LE +    L+ L+  +  AN+ RD A   + + 
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMD----LKDLEAHIDSANKNRDEAIKQLRKL 1643

Query: 642  QREKAELSRKVEELQACVE--TARQEQHEAQAQVAELELQLRSEQQKATE--KERVAQEK 697
            Q +  +  R++++ +A  E   A+ +++E + +  E E+    E+  A E  K +  QE+
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703

Query: 698  DQLQEQLQALKESLKVTKGSLE-EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756
            D+L +++     +    KG+L  EEKRR    + + +  + E +  T  + ++ K+   +
Sbjct: 1704 DELADEI-----ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758

Query: 757  LEE-------ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
            +++       ER+  +  E   QQL E    E +V  +E+   + +++ A      L  +
Sbjct: 1759 IDQINTDLNLERSHAQKNENARQQL-ERQNKELKVKLQEMEGTVKSKYKA--SITALEAK 1815

Query: 810  VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 869
            +A   E+ ++  +E        Q     ++   +K +  L +  ++    E + + Q  +
Sbjct: 1816 IAQLEEQLDNETKER-------QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD-QADK 1867

Query: 870  QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 929
                L +L   L  A ++ Q      +KL  +L    E   A ++EV+ L+  +R+ G+ 
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR-GDL 1926

Query: 930  QETASRELVKEPARAG 945
                 R + ++ A  G
Sbjct: 1927 PFVVPRRMARKGAGDG 1942


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  201 bits (510), Expect = 8e-51
 Identities = 250/1136 (22%), Positives = 501/1136 (44%), Gaps = 185/1136 (16%)

Query: 356  LEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
            L K A+ EKE++   ++ +  +++    + K  +LEE +  L       + +V  +   L
Sbjct: 842  LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901

Query: 416  ETLKQEAATLAANNTQLQARVEMLETERGQQE----AKLLAERGHFEEEKQQLSSLITDL 471
               ++    L  N  QL+A+++ + TER ++E    A+L A++   E+E  +L   I DL
Sbjct: 902  ADAEERCEQLIKNKIQLEAKIKEV-TERAEEEEEINAELTAKKRKLEDECSELKKDIDDL 960

Query: 472  QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ----- 526
            + +++ + + K   E            +V +LT E+  L+ TI +  +E   L++     
Sbjct: 961  ELTLAKVEKEKHATEN-----------KVKNLTEEMAGLDETIAKLSKEKKALQETHQQT 1009

Query: 527  ----QAKEKQAQL---AQT-LQQQEQASQGLRHQVEQLSSSLKQKEQQLK---EVAEKQE 575
                QA+E +  +   A+T L+QQ    +G   Q ++L   L++ +++L+   ++A++  
Sbjct: 1010 LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069

Query: 576  ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQ 635
               ++  QQL    E++E  +    + ++  +A+E +   K++ LQ +++   E  ++ +
Sbjct: 1070 MDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAER 1129

Query: 636  TSVTQAQREKAELSRKVEELQACVETA------------RQE---------------QHE 668
             S  +A++++++LSR++EE+   +E A            ++E               QHE
Sbjct: 1130 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189

Query: 669  AQA---------QVAELELQL----RSEQQKATEKERVAQEKDQLQEQLQAL---KESLK 712
            A            +AEL  Q+    R +Q+   EK  +  E D L    +A+   K +L+
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249

Query: 713  VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQ 772
                SLE++        EEQQR I++L A+   L  +     ++L+E+ A    L ++L 
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA----LVSQLS 1305

Query: 773  QLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ---------- 822
            +  +A   + E L+ +L E   A++      +    +    RE+YE+ Q+          
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1365

Query: 823  ----EEAQYGAMFQEQLMTLKEECEKAR----QELQEAKEKVAGIESHS---ELQISRQQ 871
                E AQ+   ++   +   EE E+A+    Q LQEA+E V  + +     E    R Q
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQ 1425

Query: 872  NELAELHANLAR------ALQQVQ--------EKEVRAQKLADDLSTLQEKMAATSKEVA 917
            NE+ +L  ++ R      AL + Q        E + + ++   +L   Q++  + S E+ 
Sbjct: 1426 NEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485

Query: 918  RLETLVRKAGEQQETASRE----------LVKEPARAGDR--QPEWLEEQQGRQFCSTQA 965
            +++ +  ++ +Q ET  RE          L ++ A  G +  + E +++Q  ++ C  QA
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545

Query: 966  ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRA----QADLA 1021
            AL+  E   E    ++ R++  L + + +   +  +++ E+ +L +   R     Q+ L 
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605

Query: 1022 LEKAARAE---LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078
             E  +R +   ++ +++  LNE  ++        A +L       +     +G+      
Sbjct: 1606 AEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESL-------RNYRNTQGILKETQL 1658

Query: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQK 1138
             L++  +  + LKEQLA  E+                     +   L+AE+ +L      
Sbjct: 1659 HLDDALRGQEDLKEQLAIVER---------------------RANLLQAEIEEL----WA 1693

Query: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTK 1198
              EQ +   +  E E    +ER   L T    L    ++L +  S L S   E+      
Sbjct: 1694 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV------ 1747

Query: 1199 VQDHSKAEDEWKAQV---ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
            +Q+   AE++ K  +   A   +E +++    + LE     L + V + +    E ++L 
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807

Query: 1256 MAESEKS-QKLEERLRLLQAETASNSARAAERSSALREEVQSLRE-----EAEKQRVAS- 1308
            +   +K  QKLE R+R L+ E  +   R AE    LR+  + ++E     E +++ V   
Sbjct: 1808 LKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRL 1867

Query: 1309 ----ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360
                + L+ ++ S   +AEE  ++  A   KF + +  L   +      ++ V++L
Sbjct: 1868 QDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKL 1923



 Score =  198 bits (504), Expect = 4e-50
 Identities = 268/1174 (22%), Positives = 505/1174 (43%), Gaps = 142/1174 (12%)

Query: 501  ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSL 560
            A    E+ T+    Q+   ELA  + + KE + ++   L+++      L+ QV+  + SL
Sbjct: 846  AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKND----LQLQVQSEADSL 901

Query: 561  KQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEIL 620
               E++ +++  K +   +   +++   AEE E    E  A  ++LE    E    ++ L
Sbjct: 902  ADAEERCEQLI-KNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL 960

Query: 621  QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
            +  L    + + + +  V     E A L   + +L    + A QE H+           L
Sbjct: 961  ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSK-EKKALQETHQQTLD------DL 1013

Query: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
            ++E+ K     +   + +Q  + L+   E  K  +  LE  KR+    L+  Q    +++
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073

Query: 741  AETRSLVEQHKRERKELE-----EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA 795
             + + L E  K E+KE E      +    + +E +LQ+  +  QA  E L  E+    A+
Sbjct: 1074 NDKQQLDE--KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131

Query: 796  QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE--KARQELQEAK 853
            +  AE +   L +E+    ER E++       GA   +  +  K E E  K R++L+EA 
Sbjct: 1132 RAKAEKQRSDLSRELEEISERLEEAG------GATSAQVELNKKREAEFQKLRRDLEEAT 1185

Query: 854  EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATS 913
             +   + +    + +    EL E   NL R  Q++++++   +   DDLS+  E   A S
Sbjct: 1186 LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAE---AIS 1242

Query: 914  KEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMERE 973
            K    LE + R   +Q      +                EE+Q R      A    ++ E
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELKTK----------------EEEQQRLINDLTAQRARLQTE 1286

Query: 974  AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE-KAARAELEM 1032
            A +   +L+  + AL+    + ++   QQ  E+    +E  +A+  LA   +++R + ++
Sbjct: 1287 AGEYSRQLDE-KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345

Query: 1033 RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQLK 1091
             L+    E++   A LQ AL+ A       + E+A+ R   E   I+  EEL +  K+L 
Sbjct: 1346 -LREQYEEEQEGKAELQRALSKA-------NSEVAQWRTKYETDAIQRTEELEEAKKKLA 1397

Query: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE 1151
            ++L + E EH                    +EA+ A+ + LE+  Q+ Q + + L   +E
Sbjct: 1398 QRLQEAE-EH--------------------VEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436

Query: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKA 1211
               A+ A  D         L E  Q+   +Q+ L ++Q+E  +  T++       +E   
Sbjct: 1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496

Query: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271
            Q+   R+E +     IS L E+++   +Q+ E E   K++++         +K E +  L
Sbjct: 1497 QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ---------EKCEIQAAL 1547

Query: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKA 1331
             +AE           +S   EE + LR + E  +V SE  R+     AE+ EE+ Q LK 
Sbjct: 1548 EEAE-----------ASLEHEEGKILRIQLELNQVKSEVDRKI----AEKDEEIDQ-LKR 1591

Query: 1332 WQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQA 1391
               +  +  Q  STL  E  S    +      +    +++ +   A +   E L   +  
Sbjct: 1592 NHTRVVETMQ--STLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT 1649

Query: 1392 AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1451
             G L+   L     L     L++++A  ER A  L+AE       L   +++  +  +E 
Sbjct: 1650 QGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709

Query: 1452 RGLGERANL----------GRQFLEVELDQAREKYVQELAAVRADAETR----------L 1491
                ER  L           ++ LE ++ Q + + V+E+     +AE +          +
Sbjct: 1710 LDASERVQLLHTQNTSLINTKKKLENDVSQLQSE-VEEVIQESRNAEEKAKKAITDAAMM 1768

Query: 1492 AEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTA-----QVEQLEVFQRE 1546
            AE  ++ Q T+  LE M    E    + +++ Q   +E ++L       Q+++LE   RE
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLE----QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE 1824

Query: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
               +VE   K+ A++ +  +  ++++K +  Q  E ++   RLQ  +++LQA++      
Sbjct: 1825 LEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKV------ 1878

Query: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
             + YK Q E+A+   +A   + ++LQ +L   E+
Sbjct: 1879 -KSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911



 Score =  189 bits (481), Expect = 2e-47
 Identities = 249/1138 (21%), Positives = 481/1138 (42%), Gaps = 140/1138 (12%)

Query: 209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEK- 267
            + T + + ++ K +LA   + R ELE ++     LL EK+     +Q   D LA   E+ 
Sbjct: 852  MATMKEEFQKTKDELAKSEAKRKELEEKMVT---LLKEKNDLQLQVQSEADSLADAEERC 908

Query: 268  ----------QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLK-------------- 303
                      +A      +  EE  + N  LT +  +   +C +LK              
Sbjct: 909  EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 968

Query: 304  TEKSQMDRKINQLSEENGDLSFKLREFASH--------------LQQLQDALNELTEEHS 349
             EK   + K+  L+EE   L   + + +                LQ  +D +N LT+  +
Sbjct: 969  KEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKT 1028

Query: 350  KATQEWLEKQAQLEKELSAAL---QDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406
            K  Q+  + +  LE+E    +   + K+ LE   ++ Q     +E    QL +   +++ 
Sbjct: 1029 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEF 1088

Query: 407  EVLGDVLQLETLKQEAATLAANNTQLQARVEML----ETERGQQEAKLLAERGHFEEEKQ 462
            E+   + ++E  +     L     +LQAR+E L    E ER  + AK   +R     E +
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR-AKAEKQRSDLSRELE 1147

Query: 463  QLSSLITDLQSSIS-----------NLSQAKEELEQASQAHGARLTAQVASLTSELTTLN 511
            ++S  + +   + S              + + +LE+A+  H     A VA+L  +     
Sbjct: 1148 EISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH----EAMVAALRKKHADSM 1203

Query: 512  ATIQQQDQELAGLKQQAKEKQAQL---AQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
            A + +Q   L  +KQ+ ++++++L      L    +A    +  +E++  SL+ +  +LK
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELK 1263

Query: 569  EVAEKQEATRQDHAQQ---LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625
               E+Q+    D   Q   L T A E    L E+DA + QL   ++    ++E L+ QL+
Sbjct: 1264 TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLE 1323

Query: 626  VANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ 685
               +A+++   ++  ++ +   L  + EE Q      ++   +A ++VA+   +  ++  
Sbjct: 1324 EETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI 1383

Query: 686  KATEKERVAQEKDQLQEQLQALKESLKVTK---GSLEEEKRRAADALEEQQRCISELKAE 742
            + TE+  + + K +L ++LQ  +E ++       SLE+ K+R  + +E+    +    A 
Sbjct: 1384 QRTEE--LEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA 1441

Query: 743  TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESE 802
              +L ++ +   K L E +   +  +A L    EA Q E+  L  EL +       +  +
Sbjct: 1442 CAALDKKQRNFDKVLSEWKQKYEETQAEL----EASQKESRSLSTELFKVKNVYEESLDQ 1497

Query: 803  CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH 862
             E L +E    ++   D  ++ A+ G    E L  +K++ E+ + E+Q A E+      H
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGKQIHE-LEKIKKQVEQEKCEIQAALEEAEASLEH 1556

Query: 863  SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR---- 918
             E +I R Q EL ++ + + R   ++ EK+    +L  + + + E M +T     R    
Sbjct: 1557 EEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRND 1613

Query: 919  -LETLVRKAGEQQE-----TASRELVKEPARAGDRQPEWLEEQQ--------GRQFCSTQ 964
             L    +  G+  E       +  L  E  R        L+E Q        G++    Q
Sbjct: 1614 ALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ 1673

Query: 965  AALQAMEREAEQMGNELERLRAALMESQGQ----QQEERGQQEREVARLTQERGRAQADL 1020
             A+  +ER A  +  E+E L A L +++      +QE     ER     TQ         
Sbjct: 1674 LAI--VERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1731

Query: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080
             LE    ++L+  ++  + E R      +E    A+T+     +EL K +   A   +  
Sbjct: 1732 KLENDV-SQLQSEVEEVIQESR----NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786

Query: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140
            + L QTVK L+ +L + E+    G   Q             ++ L A V +LE + + +Q
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQ-------------IQKLEARVRELEGEVENEQ 1833

Query: 1141 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
                  +R+ EA +  R + +  ++ L  Q EE  + +   Q  +   Q ++ +++ + +
Sbjct: 1834 ------KRNAEAVKGLR-KHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886

Query: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAE 1258
            +   AE++  A +++ R+        +   EE   I   QV +   +S+E+   + AE
Sbjct: 1887 E---AEEQSNANLSKFRKLQHE----LEEAEERADIAESQVNKLRVKSREVHTKISAE 1937



 Score =  171 bits (434), Expect = 5e-42
 Identities = 222/1049 (21%), Positives = 463/1049 (44%), Gaps = 151/1049 (14%)

Query: 737  SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
            +E + E  ++ E+ ++ + EL +  A RK LE ++  L +    E   L+ ++     + 
Sbjct: 846  AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLK----EKNDLQLQVQSEADSL 901

Query: 797  HTAESECEQLVK---EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
              AE  CEQL+K   ++ A  +   +  +EE +  A    +   L++EC + ++++ + +
Sbjct: 902  ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLE 961

Query: 854  EKVAGIESH---SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMA 910
              +A +E     +E ++     E+A L   +A+  ++ +  +   Q+  DDL   ++K+ 
Sbjct: 962  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN 1021

Query: 911  ATSKEVARLETLV----------RKAGEQQETASREL------VKEPARAGDRQPEWLEE 954
              +K   +LE  V          +K     E A R+L       +E     +   + L+E
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081

Query: 955  Q-QGRQF----------------CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE 997
            + + ++F                   Q  ++ ++   E++G E+E  RA+  +++ Q+ +
Sbjct: 1082 KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSD 1141

Query: 998  ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQ-EALAHAL 1056
               + E    RL +  G   A + L K   AE + +L+  L E     ATLQ EA+  AL
Sbjct: 1142 LSRELEEISERLEEAGGATSAQVELNKKREAEFQ-KLRRDLEE-----ATLQHEAMVAAL 1195

Query: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116
             +K      +A+L      QI  L+ ++Q +++ K +L  +  + +S + A S+A G  E
Sbjct: 1196 RKKHA--DSMAEL----GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249

Query: 1117 PTGPKLEALRAEVSKLEQQCQKQ-----------QEQADSLERSLEAERA-----SRAER 1160
                 LE   +E+   E++ Q+            Q +A    R L+ + A     SR+++
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309

Query: 1161 DSA--LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
             S   +E L+ QLEE+ +       AL S++ +    R + ++    E E KA++ R   
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE----EQEGKAELQRALS 1365

Query: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETAS 1278
            +A  + +   +  E  +I   + LE E + K  +RL        Q+ EE +  + A+ AS
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTEELE-EAKKKLAQRL--------QEAEEHVEAVNAKCAS 1416

Query: 1279 NSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQ 1338
                  +    L+ EV+ L  + E+   A   L +       +     + L  W++K+  
Sbjct: 1417 ----LEKTKQRLQNEVEDLMLDVERSNAACAALDK-------KQRNFDKVLSEWKQKY-- 1463

Query: 1339 KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAE 1398
             E+  + L+     +++L +EL   K++ ++   +Q    +R  + L+Q       L  +
Sbjct: 1464 -EETQAELEASQKESRSLSTELFKVKNVYEE-SLDQLETLRRENKNLQQE---ISDLTEQ 1518

Query: 1399 LLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ------LSMLKKAHGLLAEENR 1452
            +    +++ EL  ++++V EQE+   Q   E+A  + +      L +  + + + +E +R
Sbjct: 1519 IAEGGKQIHELEKIKKQV-EQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1577

Query: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAVRA--DAETR----LAEVQREAQSTARELE 1506
             + E+        + E+DQ +  + + +  +++  DAE R       V+++ +    E+E
Sbjct: 1578 KIAEK--------DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629

Query: 1507 VMT-----------AKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQT---KQVE 1552
            +               Y   +  + E +    +  +      EQL + +R       ++E
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIE 1689

Query: 1553 ELSKKLADSDQASKVQQQKL-------KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605
            EL   L  ++++ K+ +Q+L       + +  Q        ++L+  +++LQ+++ +  Q
Sbjct: 1690 ELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQ 1749

Query: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA-GL 1664
             + + +   EKAK          +EL+++  +   L++  K L    + L H L +A  L
Sbjct: 1750 ESRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1806

Query: 1665 KTKEAEQTCRHLTAQVRSLEAQVAHADQQ 1693
              K  ++  + L A+VR LE +V +  ++
Sbjct: 1807 ALKGGKKQIQKLEARVRELEGEVENEQKR 1835



 Score =  139 bits (349), Expect = 4e-32
 Identities = 178/801 (22%), Positives = 351/801 (43%), Gaps = 90/801 (11%)

Query: 971  EREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL 1030
            E+E   M  E ++ +  L +S+ +++E     E ++  L +E+   Q  +  E  + A+ 
Sbjct: 849  EKEMATMKEEFQKTKDELAKSEAKRKE----LEEKMVTLLKEKNDLQLQVQSEADSLADA 904

Query: 1031 EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQL 1090
            E R +  +  +    A ++E    A  E+E   +  AK R LE     E  EL++ +  L
Sbjct: 905  EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE----DECSELKKDIDDL 960

Query: 1091 KEQLAKKEKE-HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
            +  LAK EKE HA+    +++    TE    ++  L   ++KL ++ +  QE        
Sbjct: 961  ELTLAKVEKEKHAT----ENKVKNLTE----EMAGLDETIAKLSKEKKALQETHQQTLDD 1012

Query: 1150 LEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
            L+AE     ++ + L   + +LE++  +L  S       + +L   + K++   K   E 
Sbjct: 1013 LQAEE----DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1068

Query: 1210 KAQVARGRQEAERK--------NSLISSLEEEVSI---LNRQV------LEKEGESKELK 1252
               +   +Q+ + K        ++LIS +E+E ++   L +++      +E+ GE  E +
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128

Query: 1253 RLVMAESEK-----SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVA 1307
            R   A++EK     S++LEE    L+    + SA+  E +     E Q LR + E+  + 
Sbjct: 1129 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV-ELNKKREAEFQKLRRDLEEATLQ 1187

Query: 1308 SENLRQELTSQ-AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAK-- 1364
             E +   L  + A+   ELG+++   Q    + E+  S L++E     +    +  AK  
Sbjct: 1188 HEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGN 1247

Query: 1365 --HLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERT 1422
               +C+ L  E   +E + +EE +Q  +    L A+  R Q E GE     +++ E++  
Sbjct: 1248 LEKMCRSL--EDQVSELKTKEEEQQ--RLINDLTAQRARLQTEAGEY---SRQLDEKDAL 1300

Query: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
              QL   K +  +Q+  LK     L EE +     A+   Q    + D  RE+Y +E   
Sbjct: 1301 VSQLSRSKQASTQQIEELKHQ---LEEETKAKNALAH-ALQSSRHDCDLLREQYEEEQEG 1356

Query: 1483 VRADAETRLAEVQREAQSTARELEV----MTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1538
             +A+ +  L++   E      + E      T + E AK K+ +  Q  +E  + + A+  
Sbjct: 1357 -KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415

Query: 1539 QLEVFQREQTKQVEEL--------------SKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584
             LE  ++    +VE+L               KK  + D+     +QK +  QA+   SQ+
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQK 1475

Query: 1585 EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
            E++ L  +L +++    +     E  + + +  +       +Q  E  +Q+  LE+++K+
Sbjct: 1476 ESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQ 1535

Query: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL-RDLGKFQVA 1703
             ++ + E         QA L  +EAE +  H   ++  ++ ++     ++ R + +    
Sbjct: 1536 VEQEKCEI--------QAAL--EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1585

Query: 1704 TDALKSREPQAKPQLDLSIDS 1724
             D LK    +    +  ++D+
Sbjct: 1586 IDQLKRNHTRVVETMQSTLDA 1606



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 29/133 (21%), Positives = 58/133 (43%), Gaps = 12/133 (9%)

Query: 1596 LQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERL 1655
            L++  ++KE A    K + +K K      + + +EL+E++ +L    KE  +L+ + +  
Sbjct: 843  LKSAETEKEMAT--MKEEFQKTKDELAKSEAKRKELEEKMVTL---LKEKNDLQLQVQSE 897

Query: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAK 1715
               L        +AE+ C  L      LEA++    ++  +  +      A K +     
Sbjct: 898  ADSLA-------DAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDEC 950

Query: 1716 PQLDLSIDSLDLS 1728
             +L   ID L+L+
Sbjct: 951  SELKKDIDDLELT 963


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.121    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,359,024
Number of Sequences: 37866
Number of extensions: 3327655
Number of successful extensions: 90784
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 948
Number of HSP's successfully gapped in prelim test: 1699
Number of HSP's that attempted gapping in prelim test: 18816
Number of HSP's gapped (non-prelim): 23194
length of query: 2115
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1997
effective length of database: 13,779,330
effective search space: 27517322010
effective search space used: 27517322010
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.