Search of human proteins with 13699859

Search of human proteins with 13699859

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo
sapiens]
         (500 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]  1008   0.0  
gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide...   376   e-104
gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide...   258   7e-69
gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1...   242   5e-64
gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide...   106   6e-23
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...    60   5e-09
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...    58   2e-08
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...    57   4e-08
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...    55   1e-07
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...    55   2e-07
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...    54   3e-07
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide...    53   6e-07
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...    53   6e-07
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...    52   1e-06
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    52   1e-06
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...    52   1e-06
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...    52   1e-06
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...    50   6e-06
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...    50   6e-06
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...    49   8e-06
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...    49   8e-06
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...    49   1e-05
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...    49   1e-05
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...    49   1e-05
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid...    47   4e-05
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...    47   4e-05
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...    47   4e-05
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    47   5e-05
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...    46   7e-05
gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide...    46   7e-05

>gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]
          Length = 500

 Score = 1008 bits (2606), Expect = 0.0
 Identities = 500/500 (100%), Positives = 500/500 (100%)

Query: 1   MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 60
           MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
Sbjct: 1   MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 60

Query: 61  HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE 120
           HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
Sbjct: 61  HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE 120

Query: 121 KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL 180
           KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
Sbjct: 121 KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL 180

Query: 181 YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL 240
           YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
Sbjct: 181 YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL 240

Query: 241 LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 300
           LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
Sbjct: 241 LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 300

Query: 301 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 360
           KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
Sbjct: 301 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 360

Query: 361 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 420
           VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
Sbjct: 361 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 420

Query: 421 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR 480
           YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
Sbjct: 421 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR 480

Query: 481 YGFGLMQPEHDVPVRYRIRP 500
           YGFGLMQPEHDVPVRYRIRP
Sbjct: 481 YGFGLMQPEHDVPVRYRIRP 500


>gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  376 bits (965), Expect = e-104
 Identities = 204/503 (40%), Positives = 295/503 (58%), Gaps = 12/503 (2%)

Query: 3   WAALLGLLAALLL--LLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 60
           W  +LG L  ++   L L    R RRP EPPLD G++PWLG+A+ F K+   FL RM+ K
Sbjct: 4   WGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTK 63

Query: 61  HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE 120
           HGD+FT+ +GG+Y T ++DP S+ +++ + + +LDF  YA  L+ ++F  +         
Sbjct: 64  HGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEMI 123

Query: 121 KARMKLTLLHRELQALTEAMYTNLHAVLL---GDATEAGSGWHEMGLLDFSYSFLLRAGY 177
            +     L    L+ L E M  +L  V+L   G + +A S WHE  L  F Y  L  AGY
Sbjct: 124 HSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDA-SCWHEDSLFRFCYYILFTAGY 182

Query: 178 LTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRL 237
           L+L+G        + + QD + + ++F  FR+ D L P+     L   +   +  ++   
Sbjct: 183 LSLFGYT------KDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLF 236

Query: 238 WKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLL 297
            K+LS +    +   S WL + L  L E GV   MQ +   + LWA+QGN GP +FW LL
Sbjct: 237 HKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALL 296

Query: 298 FLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFI 357
           +LLK+PEA+ AVR E   +L +A     Q+       L  TPVLDSV+ E+LRL AAP +
Sbjct: 297 YLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTL 356

Query: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 417
            R V  D  + M+ G+E+  R GD L LFP+LS   DP+I+ +P VFKY+RFLNP+GS K
Sbjct: 357 LRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRK 416

Query: 418 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFD 477
            DF+K GK++ +Y MPWG+G + C GR +A++ +K F+ L++ H DLEL++ D  +P  D
Sbjct: 417 VDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVD 476

Query: 478 LSRYGFGLMQPEHDVPVRYRIRP 500
             R+GFG MQP HDV  RYR+ P
Sbjct: 477 PQRWGFGTMQPSHDVRFRYRLHP 499


>gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  258 bits (660), Expect = 7e-69
 Identities = 166/509 (32%), Positives = 264/509 (51%), Gaps = 22/509 (4%)

Query: 1   MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 60
           + W   +     L L+L + RR+T   GEPPL+ G IP+LG AL FG +   FL   + K
Sbjct: 6   LIWGIAIAACCCLWLILGIRRRQT---GEPPLENGLIPYLGCALQFGANPLEFLRANQRK 62

Query: 61  HGDIFTILVGGRYVTVLLDPHSYDAVVWEPR----TRLDFHAYAIFLMERIFDVQLPHYS 116
           HG +FT  + G+YV  + +P SY  V+   +     +  F   A     R  D    + +
Sbjct: 63  HGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTT 122

Query: 117 PSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAG--SGWHEMGLLDFSYSFLLR 174
            +     +K TL    L +LTE+M  NL  ++    +     + W   G+  F Y  +  
Sbjct: 123 ENINDTFIK-TLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFE 181

Query: 175 AGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVK 234
           AGYLT++G +   R  +     + H  +    F+Q D++ P L  G L +       + +
Sbjct: 182 AGYLTIFGRDLTRRDTQ-----KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRTAHNAR 235

Query: 235 SRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ-ARALVLQLWATQGNMGPAAF 293
            +L + L    L +R   S+ +   +   + +   ++++ A+  ++ LWA+Q N  PA F
Sbjct: 236 EKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF 295

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVS---QTTTLPQKVLDSTPVLDSVLSESLR 350
           W L  +++NPEA+ A   E++  L  A Q VS       L Q  L+  PVLDS++ ESLR
Sbjct: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355

Query: 351 LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL 410
           L++A    R    D  + + DG  +N+R+ D + L+P L    DPEIY DP  FKY+R+L
Sbjct: 356 LSSASLNIRTAKEDFTLHLEDG-SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYL 413

Query: 411 NPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINAD 470
           + +G  K  FY +G +LK Y MP+G+G   C GR +A++ IKQF+ L+L + +LELI   
Sbjct: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQ 473

Query: 471 VEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499
            + P  D SR G G++ P +D+  +Y+ +
Sbjct: 474 AKCPPLDQSRAGLGILPPLNDIEFKYKFK 502


>gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 506

 Score =  242 bits (618), Expect = 5e-64
 Identities = 170/499 (34%), Positives = 267/499 (53%), Gaps = 21/499 (4%)

Query: 7   LGLLAALLLLLL-LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIF 65
           L L AALLLL L L  RRTRRPGEPPL  G +P+LG  L+  KD   F+  ++++HGD F
Sbjct: 22  LALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTF 81

Query: 66  TILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQ--LPHYSPSDEKAR 123
           T+L+GG+Y+T +LDP  Y  V+ +   +L F  ++  L+E+ F +     ++  +DE   
Sbjct: 82  TVLLGGKYITFILDPFQYQLVI-KNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHL 140

Query: 124 MKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGI 183
               L  + L  L E+M  NL  V      +  S W    L  F  S +    + T+YG 
Sbjct: 141 CYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTS-WDTAELYPFCSSIIFEITFTTIYGK 199

Query: 184 EALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSP 243
             +   ++  ++ R         F  L   +P    G++         S++ ++ K  S 
Sbjct: 200 VIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVK--------SIREKIIKCFSS 251

Query: 244 ARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ-LWATQGNMGPAAFWLLLFLLKN 302
            +LA+    S+  +S    LE+  V E+++  A  L  LWA+  N  P  FW + +LL++
Sbjct: 252 EKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRH 311

Query: 303 PEALAAVRGELESILWQAEQPVSQ--TTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 360
           PEA+AAVR E++ +L    Q         L ++ LDS   L+S + E+LRL++     R 
Sbjct: 312 PEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRF 371

Query: 361 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 420
           V  DL +    G ++ +R+GD + +FP +    DPEI+  PE F+Y+RF+  DG +K  F
Sbjct: 372 VEEDLTLSSETG-DYCVRKGDLVAIFPPVL-HGDPEIFEAPEEFRYDRFIE-DGKKKTTF 428

Query: 421 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR 480
           +K GK+LK Y MP+G G + C GR +A+  IKQ + ++L + DLE+I  D +    + SR
Sbjct: 429 FKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEII--DDKPIGLNYSR 486

Query: 481 YGFGLMQPEHDVPVRYRIR 499
             FG+  P+ DV  RY+++
Sbjct: 487 LLFGIQYPDSDVLFRYKVK 505


>gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 469

 Score =  106 bits (264), Expect = 6e-23
 Identities = 120/504 (23%), Positives = 213/504 (42%), Gaps = 59/504 (11%)

Query: 9   LLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTIL 68
           +L  L L LLL R+  RRP   P   G IPW+G   +FGK    F+ + + K+G IFT+ 
Sbjct: 11  ILGCLALFLLLQRKNLRRP---PCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVF 67

Query: 69  VGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEK------A 122
             G  +T + +    +  V+    ++DF      ++ R   +    +    EK       
Sbjct: 68  AMGNRMTFVTEEEGIN--VFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKG 125

Query: 123 RMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYG 182
           +M    LH+    LTE ++  L  +          G H    L+     LL    + +  
Sbjct: 126 KMGTVNLHQFTGQLTEELHEQLENL----------GTHGTMDLNNLVRHLLYPVTVNMLF 175

Query: 183 IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLW---- 238
            ++L  T++ + ++      V+    +    LP+    + S          KS+ W    
Sbjct: 176 NKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWS----------KSKKWFLEL 225

Query: 239 --KLLSPARLARRAH-RSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWL 295
             K +   +  + A   S  L    L + E   S+E      +L LWA+  N  P AFW 
Sbjct: 226 FEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWT 285

Query: 296 LLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAP 355
           L ++L +P+   A+   + S+  +A +       + +  L++  ++   + E++RL A  
Sbjct: 286 LAYVLSHPDIHKAIMEGISSVFGKAGK---DKIKVSEDDLENLLLIKWCVLETIRLKAPG 342

Query: 356 FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 415
            ITR+VV  + +       + +  GD L+L PF    R+P+ + +PE+FK  R+   +  
Sbjct: 343 VITRKVVKPVEI-----LNYIIPSGDLLMLSPFWL-HRNPKYFPEPELFKPERWKKAN-L 395

Query: 416 EKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475
           EK  F        +  M +G+G   C  R +A+  ++  + L+L   D  L++   +   
Sbjct: 396 EKHSFL-------DCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSY 448

Query: 476 FDLSRYGFGLMQPEHDVPVRYRIR 499
             L     G+ QPE    + Y+ R
Sbjct: 449 LHL----VGVPQPEGQCRIEYKQR 468


>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 106/480 (22%), Positives = 197/480 (41%), Gaps = 49/480 (10%)

Query: 30  PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWE 89
           PP     IP+LG+A+ FGK    FL    EK+G +F+  + G+  T LL   +  A+++ 
Sbjct: 67  PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDA-AALLFN 125

Query: 90  PRTRLDFHAYAIF--LMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAV 147
            +   D +A  ++  L   +F   + +  P+      K  L       L  A +    ++
Sbjct: 126 SKNE-DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKML----KSGLNIAHFKQHVSI 180

Query: 148 LLGDATEAGSGWHEMG---LLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVF 204
           +  +  E    W E G   + +     ++      L+G E   + +E  AQ     AD+ 
Sbjct: 181 IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQ---LYADLD 237

Query: 205 HTFRQLDRLLPK-LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYL--L 261
             F     LLP  L   S    D+ H   +K   +K +   R ++       L++ L   
Sbjct: 238 GGFSHAAWLLPGWLPLPSFRRRDRAHR-EIKDIFYKAIQKRRQSQE-KIDDILQTLLDAT 295

Query: 262 HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAE 321
           + +   ++++  A  L+  L A Q      + W+  FL ++         E +++  +  
Sbjct: 296 YKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENL 355

Query: 322 QPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGD 381
            P      L    L    +LD  + E+LRL   P +   +++ +A        + +  G 
Sbjct: 356 PP------LTYDQLKDLNLLDRCIKETLRL-RPPIM---IMMRMARTPQTVAGYTIPPGH 405

Query: 382 RLLLFPFLSPQRDPEIYTDPEVFKYNRFL--NPDGSEKKDFYKDGKRLKNYNMPWGAGHN 439
           ++ + P ++ QR  + + +   F  +R+L  NP   EK  +           +P+GAG +
Sbjct: 406 QVCVSPTVN-QRLKDSWVERLDFNPDRYLQDNPASGEKFAY-----------VPFGAGRH 453

Query: 440 HCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499
            C+G ++A   IK     +L   + +LI+       F    Y   +  PE+ V +RY+ R
Sbjct: 454 RCIGENFAYVQIKTIWSTMLRLYEFDLIDG-----YFPTVNYTTMIHTPENPV-IRYKRR 507


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 49/169 (28%), Positives = 84/169 (49%), Gaps = 20/169 (11%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L ++PE     R E++ +L   +    +   L Q      P L   + ESLRL  
Sbjct: 339 WVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQ-----LPFLTMCVKESLRLHP 393

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
            APFI+R    D+ +P  DGR   + +G   L+   +    +P ++ DPEV+   RF +P
Sbjct: 394 PAPFISRCCTQDIVLP--DGRV--IPKGITCLI-DIIGVHHNPTVWPDPEVYDPFRF-DP 447

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461
           + S+         R     +P+ AG  +C+G+++A+  +K  + L+L+H
Sbjct: 448 ENSKG--------RSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLH 488


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 44/173 (25%), Positives = 79/173 (45%), Gaps = 22/173 (12%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W L  L  NPE    V  EL+ +  ++++P +         L     L+ V+ E+LRL  
Sbjct: 340 WSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVED------LKKLRYLECVIKETLRLFP 393

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
           + P   R V  D  +       + + +G   ++ P+ +  RDP  + +PE F+  RF  P
Sbjct: 394 SVPLFARSVSEDCEVA-----GYRVLKGTEAVIIPY-ALHRDPRYFPNPEEFQPERFF-P 446

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE 465
           + ++ +  Y          +P+ AG  +C+G+ +AV   K  +  +L H  +E
Sbjct: 447 ENAQGRHPYA--------YVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 68/254 (26%), Positives = 98/254 (38%), Gaps = 41/254 (16%)

Query: 249 RAHRSKWLESYLLHLEE-------MGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLK 301
           R +   +++ YLLH+EE           EE     +     A       +  W LL++  
Sbjct: 311 RENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSL 370

Query: 302 NPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREV 361
           NP+    V  E+E ++     P     +L  K     P  ++ + E  RLT        V
Sbjct: 371 NPDVQEKVHEEIERVIGANRAP-----SLTDKA--QMPYTEATIMEVQRLT--------V 415

Query: 362 VVDLAMPMADGRE-----FNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSE 416
           VV LA+P           + + +G  L+L    S  RDP I+  PE F  NRFL+  G  
Sbjct: 416 VVPLAIPHMTSENTVLQGYTIPKGT-LILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQL 474

Query: 417 KKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEF 476
            K         K   +P+G G   C+G   A    K  +FL+ V L      A  E  + 
Sbjct: 475 IK---------KETFIPFGIGKRVCMGEQLA----KMELFLMFVSLMQSFAFALPEDSKK 521

Query: 477 DLSRYGFGLMQPEH 490
            L    FGL    H
Sbjct: 522 PLLTGRFGLTLAPH 535


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 107/527 (20%), Positives = 218/527 (41%), Gaps = 80/527 (15%)

Query: 9   LLAALLLLLLLSRRRTRR-------PGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKH 61
           L+A  L+LL +    + +       PG  PL     P+LG  L + +   +F     EK+
Sbjct: 14  LVATSLVLLYIYGTHSHKLFKKLGIPGPTPL-----PFLGTILFYLRGLWNFDRECNEKY 68

Query: 62  GDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERI-----FDVQLPHYS 116
           G+++ +  G + + V++DP     V+ +         Y++F  +       F      ++
Sbjct: 69  GEMWGLYEGQQPMLVIMDPDMIKTVLVK-------ECYSVFTNQMPLGPMGFLKSALSFA 121

Query: 117 PSDEKARMKLTLLHRELQALTEAMYTNLHAV-------LLGDATEAGSGWHEMGLLDFSY 169
             +E  R++ TLL     A T   +  +  +       L+    +       + L DF  
Sbjct: 122 EDEEWKRIR-TLLS---PAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177

Query: 170 SFLLRAGYLTLYGIEA----LPRTHESQAQDRVHSADVFHTFRQLDRLLPKLAR--GSLS 223
           ++ +     TL+G+       P+    +   ++   D    F  L  L P L     +L+
Sbjct: 178 AYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALN 237

Query: 224 VG--DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARAL---- 277
           +G   KD    +K+ + ++       ++ HR  + +  +   +     E    +AL    
Sbjct: 238 IGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMI---DSQNSKETKSHKALSDLE 294

Query: 278 -----VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQ 332
                ++ ++A          +++  L  +P+    ++ E++++L   + PV+    +  
Sbjct: 295 LVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQM 353

Query: 333 KVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ 392
           + LD       V++E+LRL   P ++R  V  +     +     + +G  +++ P  +  
Sbjct: 354 EYLDM------VVNETLRLF--PVVSR--VTRVCKKDIEINGVFIPKGLAVMV-PIYALH 402

Query: 393 RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIK 452
            DP+ +T+PE F   RF       KK+  KD   L  Y +P+GAG  +C+G  +A+ +IK
Sbjct: 403 HDPKYWTEPEKFCPERF------SKKN--KDSIDLYRY-IPFGAGPRNCIGMRFALTNIK 453

Query: 453 QFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499
             V   L +   +    + +IP   L      ++QPE  + ++  +R
Sbjct: 454 LAVIRALQNFSFKPCK-ETQIP---LKLDNLPILQPEKPIVLKVHLR 496


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 48/168 (28%), Positives = 80/168 (47%), Gaps = 20/168 (11%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L K+PE     R E++ +L   E    +   L        P L   + ESLRL  
Sbjct: 339 WVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAH-----LPFLTMCMKESLRLHP 393

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
             P I+R V  D+ +P  DGR   + +G   L+  F     +P ++ DPEV+   RF +P
Sbjct: 394 PVPVISRHVTQDIVLP--DGRV--IPKGIICLISVF-GTHHNPAVWPDPEVYDPFRF-DP 447

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460
           +  +        +R     +P+ AG  +C+G+++A+  +K  + L L+
Sbjct: 448 ENIK--------ERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLL 487


>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 503

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 27/191 (14%)

Query: 284 TQGNMGPAAFWLLLFLL---KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340
           T G++    F LL+ L    +NP    A+R E  +    A   +S+    PQK     P+
Sbjct: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA----AAASISEH---PQKATTELPL 364

Query: 341 LDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399
           L + L E+LRL     F+ R    DL +     + +++  G  + +F + S  R+P ++ 
Sbjct: 365 LRAALKETLRLYPVGLFLERVASSDLVL-----QNYHIPAGTLVRVFLY-SLGRNPALFP 418

Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459
            PE +   R+L+  GS +            Y++P+G G   CLGR  A   +   +  VL
Sbjct: 419 RPERYNPQRWLDIRGSGRNF----------YHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468

Query: 460 VHLDLELINAD 470
            HL +E +  +
Sbjct: 469 KHLQVETLTQE 479


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 24/172 (13%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L  +P+     R E+ S+L           ++    LD  P     + E+LRL  
Sbjct: 332 WILYALATHPKHQERCREEIHSLLGDG-------ASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
             P I RE+   +  P  DGR  +L +G  +LL  +     +P+++ +PEVF   RF   
Sbjct: 385 PVPGIGRELSTPVTFP--DGR--SLPKGIMVLLSIY-GLHHNPKVWPNPEVFDPFRFAPG 439

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDL 464
                  F           +P+  G  +C+G+ +A+N +K    L L+  +L
Sbjct: 440 SAQHSHAF-----------LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 28/172 (16%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L K+PE     R E++ +L   E    +   L Q      P L   + ESLRL  
Sbjct: 339 WVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQ-----LPFLTMCIKESLRLHP 393

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
             P ++R    D+ +P  DGR   + +G   L+  F     +P ++ DPEV+   RF   
Sbjct: 394 PVPAVSRCCTQDIVLP--DGRV--IPKGIICLISVF-GTHHNPAVWPDPEVYDPFRF--- 445

Query: 413 DGSEKKDFYKDGKRLKNYN----MPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460
                     D K +K  +    +P+ AG  +C+G+++A+  +K  + L L+
Sbjct: 446 ----------DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL 487


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 47/169 (27%), Positives = 77/169 (45%), Gaps = 20/169 (11%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L K+PE     R E++ +L   E    +   L Q      P L   + ESLRL  
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQ-----LPFLTMCIKESLRLHP 393

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
             P I+R    D  +P  DGR   + +G  + L   +    +P ++ DPEV+   RF   
Sbjct: 394 PVPVISRCCTQDFVLP--DGRV--IPKGI-VCLINIIGIHYNPTVWPDPEVYDPFRFDQE 448

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461
           +  E+              +P+ AG  +C+G+++A+  +K  + L L+H
Sbjct: 449 NIKERSPLAF---------IPFSAGPRNCIGQAFAMAEMKVVLALTLLH 488


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 47/169 (27%), Positives = 77/169 (45%), Gaps = 20/169 (11%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L K+PE     R E++ +L   E    +   L Q      P L   + ESLRL  
Sbjct: 339 WVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQ-----LPFLTMCIKESLRLHP 393

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
             P I+R    D  +P  DGR   + +G  + L   +    +P ++ DPEV+   RF   
Sbjct: 394 PVPVISRCCTQDFVLP--DGRV--IPKGI-VCLINIIGIHYNPTVWPDPEVYDPFRFDQE 448

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461
           +  E+              +P+ AG  +C+G+++A+  +K  + L L+H
Sbjct: 449 NIKERSPLAF---------IPFSAGPRNCIGQAFAMAEMKVVLALTLLH 488


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 101/527 (19%), Positives = 214/527 (40%), Gaps = 79/527 (14%)

Query: 9   LLAALLLLLLLSRRRTRR-------PGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKH 61
           L+A  L+LL +    + +       PG  PL     P+LG  L + +   +F     EK+
Sbjct: 14  LVATSLVLLYIYGTHSHKLFKKLGIPGPTPL-----PFLGTILFYLRGLWNFDRECNEKY 68

Query: 62  GDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERI-----FDVQLPHYS 116
           G+++ +  G + + V++DP     V+ +         Y++F  +       F      ++
Sbjct: 69  GEMWGLYEGQQPMLVIMDPDMIKTVLVK-------ECYSVFTNQMPLGPMGFLKSALSFA 121

Query: 117 PSDEKARMKLTLLHRELQALTEAMYTNLHAV-------LLGDATEAGSGWHEMGLLDFSY 169
             +E  R++ TLL     A T   +  +  +       L+    +       + L DF  
Sbjct: 122 EDEEWKRIR-TLLS---PAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177

Query: 170 SFLLRAGYLTLYGIEA----LPRTHESQAQDRVHSADVFHTFRQLDRLLPKLAR--GSLS 223
           ++ +     TL+G+       P+    +   ++   D    F  L  L P L     +L+
Sbjct: 178 AYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALN 237

Query: 224 VG--DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARAL---- 277
           +G   KD    +K+ + ++       ++ HR  + +  +   +     E    +AL    
Sbjct: 238 IGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMI---DSQNSKETKSHKALSDLE 294

Query: 278 -----VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQ 332
                ++ ++A          +++  L  +P+    ++ E++++L   + PV+    +  
Sbjct: 295 LVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQM 353

Query: 333 KVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ 392
           + LD       V++E+LRL   P ++R  V  +     +     + +G  +++ P  +  
Sbjct: 354 EYLDM------VVNETLRLF--PVVSR--VTRVCKKDIEINGVFIPKGLAVMV-PIYALH 402

Query: 393 RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIK 452
            DP+ +T+PE F      +    +  D Y+         +P+GAG  +C+G  +A+ +IK
Sbjct: 403 HDPKYWTEPEKFCPESRFSKKNKDSIDLYR--------YIPFGAGPRNCIGMRFALTNIK 454

Query: 453 QFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499
             V   L +   +    + +IP   L      ++QPE  + ++  +R
Sbjct: 455 LAVIRALQNFSFKPCK-ETQIP---LKLDNLPILQPEKPIVLKVHLR 497


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 44/174 (25%), Positives = 77/174 (44%), Gaps = 24/174 (13%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-- 351
           + LL LLK+PE  A V+ E+E ++ +   P  Q  +         P  D+V+ E  R   
Sbjct: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS-------HMPYTDAVVHEVQRYID 360

Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411
                +   V  D+       R + + +G  +L+    S   D + + +PE+F  + FL+
Sbjct: 361 LLPTSLPHAVTCDIKF-----RNYLIPKGTTILI-SLTSVLHDNKEFPNPEMFDPHHFLD 414

Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE 465
             G+ KK           Y MP+ AG   C+G + A   +  F+  +L + +L+
Sbjct: 415 EGGNFKK---------SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 24/174 (13%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-- 351
           + LL LLK+PE  A V+ E+E ++ +   P  Q            P  D+V+ E  R   
Sbjct: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-------GHMPYTDAVVHEVQRYID 360

Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411
                +   V  D+       R + + +G  +L     S   D + + +PE+F    FL+
Sbjct: 361 LIPTSLPHAVTCDVKF-----RNYLIPKGTTILT-SLTSVLHDNKEFPNPEMFDPRHFLD 414

Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE 465
             G+ KK          NY MP+ AG   C+G   A   +  F+  +L + +L+
Sbjct: 415 EGGNFKK---------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 26/82 (31%), Positives = 42/82 (51%), Gaps = 5/82 (6%)

Query: 6  LLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDI 64
          +L L  + LLLL + R+ + R G+ P     +P +G  L    KD +  LT + + +G +
Sbjct: 6  VLVLCLSCLLLLSIWRQSSGR-GKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 65 FTILVGGRYVTVLLDPHSYDAV 86
          FT+  G   + VL   H Y+ V
Sbjct: 65 FTLYFGLERMVVL---HGYEVV 83


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 53/221 (23%), Positives = 94/221 (42%), Gaps = 34/221 (15%)

Query: 255 WLESYLLHL--EEMGVSEEMQARALVLQLW----ATQGNMGPAAFWLLLFLLKNPEALAA 308
           +++S+L+H+  EE   + E   + L++       A    +     +  L L+K+PE  A 
Sbjct: 216 FIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAK 275

Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL--TAAPFITREVVVDLA 366
           V  E++ ++ +  QP  +  T         P +++V+ E  R        + R V  D  
Sbjct: 276 VHEEIDRVIGKNRQPKFEDRT-------KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTK 328

Query: 367 MPMADGREFNLRRGDRLLLFPFL-SPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGK 425
                 R+F L +G  +  FP L S  RDP  +++P+ F    FL+  G  KK       
Sbjct: 329 F-----RDFFLPKGTEV--FPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKK------- 374

Query: 426 RLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466
              +  +P+  G  +C G   A   ++ F+F   V  +  L
Sbjct: 375 --SDAFVPFSIGKRNCFGEGLA--RMELFLFFTTVMQNFRL 411


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 53/221 (23%), Positives = 94/221 (42%), Gaps = 34/221 (15%)

Query: 255 WLESYLLHL--EEMGVSEEMQARALVLQLW----ATQGNMGPAAFWLLLFLLKNPEALAA 308
           +++S+L+H+  EE   + E   + L++       A    +     +  L L+K+PE  A 
Sbjct: 267 FIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAK 326

Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL--TAAPFITREVVVDLA 366
           V  E++ ++ +  QP  +  T         P +++V+ E  R        + R V  D  
Sbjct: 327 VHEEIDRVIGKNRQPKFEDRT-------KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTK 379

Query: 367 MPMADGREFNLRRGDRLLLFPFL-SPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGK 425
                 R+F L +G  +  FP L S  RDP  +++P+ F    FL+  G  KK       
Sbjct: 380 F-----RDFFLPKGTEV--FPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKK------- 425

Query: 426 RLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466
              +  +P+  G  +C G   A   ++ F+F   V  +  L
Sbjct: 426 --SDAFVPFSIGKRNCFGEGLA--RMELFLFFTTVMQNFRL 462


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 45/172 (26%), Positives = 77/172 (44%), Gaps = 28/172 (16%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-- 351
           W+L  L ++PE     R E++ +L   E    +   L Q      P L   L ESLRL  
Sbjct: 339 WVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ-----LPFLTMCLKESLRLHP 393

Query: 352 ---TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNR 408
              T A   T++VV+  +  +  G   N+            +   +P ++ DPEV+   R
Sbjct: 394 PIPTFARGCTQDVVLPDSRVIPKGNVCNIN---------IFAIHHNPSVWPDPEVYDPFR 444

Query: 409 FLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460
           F +P+ ++        KR     +P+ AG  +C+G+ +A+  +K  + L L+
Sbjct: 445 F-DPENAQ--------KRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLL 487


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 27/165 (16%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W LL++   PE    V+ E++ ++ Q +QP +          +S P  ++V+ E  R+  
Sbjct: 322 WALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR-------ESMPYTNAVIHEVQRMGN 374

Query: 353 AAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411
             P  + REV VD  +       ++L +G  ++L    +  RDP  +  P+ F  + FL 
Sbjct: 375 IIPLNVPREVTVDTTL-----AGYHLPKG-TMILTNLTALHRDPTEWATPDTFNPDHFLE 428

Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVF 456
               +K++ +          MP+  G   CLG   A   +  F+F
Sbjct: 429 NGQFKKREAF----------MPFSIGKRACLGEQLARTEL--FIF 461


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 47/182 (25%), Positives = 77/182 (42%), Gaps = 26/182 (14%)

Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352
           W+L  L  +P+     R E+  +L           ++    LD  P     + E+LRL  
Sbjct: 332 WILYALATHPKHQERCREEIHGLLGDG-------ASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412
             P I RE+   +  P  DGR  +L +G  +LL  +     +P+++ + EVF  +RF   
Sbjct: 385 PVPGIGRELSTPVTFP--DGR--SLPKGIMVLLSIY-GLHHNPKVWPNLEVFDPSRFAPG 439

Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVE 472
                  F           +P+  G  +C+G+ +A+N +K  V   L  L  EL+     
Sbjct: 440 SAQHSHAF-----------LPFSGGSRNCIGKQFAMNQLK--VARALTLLRFELLPDPTR 486

Query: 473 IP 474
           IP
Sbjct: 487 IP 488


>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
           precursor [Homo sapiens]
          Length = 503

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 27/191 (14%)

Query: 284 TQGNMGPAAFWLLLFLL---KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340
           T G++   AF LL+ L    +NP+    +R E  +    A   +S+    PQK     P+
Sbjct: 312 TAGSVDTTAFPLLMTLFELARNPDVQQILRQESLA----AAASISEH---PQKATTELPL 364

Query: 341 LDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399
           L + L E+LRL     F+ R V  DL +     + +++  G  + +F + S  R+  ++ 
Sbjct: 365 LRAALKETLRLYPVGLFLERVVSSDLVL-----QNYHIPAGTLVQVFLY-SLGRNAALFP 418

Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459
            PE +   R+L+  GS +            +++P+G G   CLGR  A   +   +  VL
Sbjct: 419 RPERYNPQRWLDIRGSGRNF----------HHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468

Query: 460 VHLDLELINAD 470
            H  +E +  +
Sbjct: 469 KHFLVETLTQE 479


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 41/175 (23%), Positives = 75/175 (42%), Gaps = 24/175 (13%)

Query: 296 LLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--A 353
           LL LLK+PE  A V+ E++ ++ +   P  Q  +         P  D+V+ E  R +   
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRS-------HMPYTDAVVHEIQRYSDLV 362

Query: 354 APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPD 413
              +   V  D        R + + +G  ++     S   D + + +P +F    FL+ +
Sbjct: 363 PTGVPHAVTTDTKF-----RNYLIPKGTTIMAL-LTSVLHDDKEFPNPNIFDPGHFLDKN 416

Query: 414 GSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELIN 468
           G+ KK          +Y MP+ AG   C G   A   +  F+  +L + +L+ ++
Sbjct: 417 GNFKK---------SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 462


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 52/190 (27%), Positives = 74/190 (38%), Gaps = 22/190 (11%)

Query: 277 LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLD 336
           ++  L+A    +     + LL L+K P     VR EL   L   + P     T       
Sbjct: 296 VIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRT------- 348

Query: 337 STPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFL-SPQRDP 395
             P  D+VL E+ RL A   +    +    M     R + L +G  +  FP L S   DP
Sbjct: 349 RLPYTDAVLHEAQRLLA---LVPMGIPRTLMRTTRFRGYTLPQGTEV--FPLLGSILHDP 403

Query: 396 EIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455
            I+  PE F  +RFL+ DG  +K             +P+  G   CLG   A   +  F 
Sbjct: 404 NIFKHPEEFNPDRFLDADGRFRK---------HEAFLPFSLGKRVCLGEGLAKAELFLFF 454

Query: 456 FLVLVHLDLE 465
             +L    LE
Sbjct: 455 TTILQAFSLE 464



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/78 (43%), Positives = 42/78 (53%), Gaps = 4/78 (5%)

Query: 3  WAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAA-SFLTRMKEKH 61
          WA LL L  ALLLLL L+   TR  G  P     +P LG  L     A  S L R+ +K+
Sbjct: 7  WALLLAL--ALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKY 64

Query: 62 GDIFTILVG-GRYVTVLL 78
          G +FTI +G  R V VL+
Sbjct: 65 GPVFTIYLGPWRPVVVLV 82


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 115/527 (21%), Positives = 201/527 (38%), Gaps = 89/527 (16%)

Query: 9   LLAALLLLLLLSRRRTRR-------PGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKH 61
           LLA  L+LL L   RT         PG  PL     P LG  L + +    F T   +K+
Sbjct: 14  LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL-----PLLGNVLSYRQGLWKFDTECYKKY 68

Query: 62  GDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERI-----FDVQLPHYS 116
           G ++    G   V  + DP   D +    RT L    Y++F   R      F       +
Sbjct: 69  GKMWGTYEGQLPVLAITDP---DVI----RTVLVKECYSVFTNRRSLGPVGFMKSAISLA 121

Query: 117 PSDEKARMKLTLLHRELQALTEAMYTNLHA---VLLGDATEAGSGWHEMGLLDF--SYSF 171
             +E  R++  L         + M+  +     VL+ +          + L D   +YS 
Sbjct: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181

Query: 172 LLRAGYLTLYGIEALPRTHESQAQDR-VHSADVFHTFRQLDRLL----------PKLARG 220
            +  G      I++L     +  QD  V S   F  F  LD L           P     
Sbjct: 182 DVITGTSFGVNIDSL-----NNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEAL 236

Query: 221 SLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARAL--- 277
           ++S+  KD +  +   + ++       ++ HR  +L+   L ++     E    +AL   
Sbjct: 237 NVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ---LMIDSQNSKETESHKALSDL 293

Query: 278 ------VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 331
                 ++ ++A          + L  L  +P+    ++ E++++L     P        
Sbjct: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353

Query: 332 QKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFN---LRRGDRLLLFPF 388
           +        LD V++E+LRL         V + L        E N   + +G  +++ P 
Sbjct: 354 E-------YLDMVVNETLRLFP-------VAIRLERTCKKDVEINGVFIPKGS-MVVIPT 398

Query: 389 LSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAV 448
            +   DP+ +T+PE F+  RF     S+KKD             P+G G  +C+G  +A+
Sbjct: 399 YALHHDPKYWTEPEEFRPERF-----SKKKDSID-----PYIYTPFGTGPRNCIGMRFAL 448

Query: 449 NSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVR 495
            ++K  +  VL +   +    + +IP   L     GL+QPE  + ++
Sbjct: 449 MNMKLALIRVLQNFSFKPCK-ETQIP---LKLDTQGLLQPEKPIVLK 491


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 55/229 (24%), Positives = 103/229 (44%), Gaps = 33/229 (14%)

Query: 270 EEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTT 329
           +E+ A    LQL A +     +  W+L  L +NP+    +  E++S+L + + P ++   
Sbjct: 314 KELYAAVTELQLAAVETTAN-SLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-- 370

Query: 330 LPQKVLDSTPVLDSVLSESLRLT-AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPF 388
                L + P L + L ES+RLT + PF TR   +D A  +    E+ L +G  L+L   
Sbjct: 371 -----LRNMPYLKACLKESMRLTPSVPFTTR--TLDKATVLG---EYALPKGTVLMLNTQ 420

Query: 389 LSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAV 448
           +    + + + D   F+  R+L     EK + +         ++P+G G   C+GR  A 
Sbjct: 421 VLGSSE-DNFEDSSQFRPERWLQE--KEKINPFA--------HLPFGVGKRMCIGRRLAE 469

Query: 449 NSIKQFVFLVLVHLDLELI-NADVEIPEFDLSRYGFGLMQPEHDVPVRY 496
             +   +  ++   D++   N  VE+          G + P  ++P+ +
Sbjct: 470 LQLHLALCWIVRKYDIQATDNEPVEM-------LHSGTLVPSRELPIAF 511


>gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 428

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 54/217 (24%), Positives = 95/217 (43%), Gaps = 22/217 (10%)

Query: 256 LESYLLHLEEMGVSEEMQA--RALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGEL 313
           L+  + H  E G   +MQA  ++    L+        AA  L+ +L   P  L  VR EL
Sbjct: 202 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 261

Query: 314 ES--ILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMAD 371
           +S  +L ++    +Q   L  ++L+    +  V+ E+LRL   P +     V L     +
Sbjct: 262 KSKGLLCKS----NQDNKLDMEILEQLKYIGCVIKETLRLN--PPVPGGFRVALKTFELN 315

Query: 372 GREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYN 431
           G  + + +G  ++ +         EI+T+ E F  +RF+ P   +   F           
Sbjct: 316 G--YQIPKGWNVI-YSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSF--------- 363

Query: 432 MPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELIN 468
           +P+G G   C+G+ +A   +K F   +  H D +L+N
Sbjct: 364 IPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLN 400


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,979,594
Number of Sequences: 37866
Number of extensions: 832395
Number of successful extensions: 1963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 1862
Number of HSP's gapped (non-prelim): 88
length of query: 500
length of database: 18,247,518
effective HSP length: 106
effective length of query: 394
effective length of database: 14,233,722
effective search space: 5608086468
effective search space used: 5608086468
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.