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Search of human proteins with 6912650
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912650 semaphorin 3E [Homo sapiens]
(775 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912650 semaphorin 3E [Homo sapiens] 1615 0.0
gi|5174673 semaphorin 3A precursor [Homo sapiens] 786 0.0
gi|9910362 semaphorin sem2 [Homo sapiens] 771 0.0
gi|41406086 semaphorin 3D [Homo sapiens] 718 0.0
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 667 0.0
gi|188497703 semaphorin 3F [Homo sapiens] 663 0.0
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 662 0.0
gi|5454048 semaphorin 3C [Homo sapiens] 648 0.0
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 322 8e-88
gi|157388902 semaphorin 4C [Homo sapiens] 315 1e-85
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 309 7e-84
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 299 8e-81
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 298 1e-80
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 298 1e-80
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 298 1e-80
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 297 3e-80
gi|39777610 semaphorin 4B precursor [Homo sapiens] 290 4e-78
gi|39777608 semaphorin 4B precursor [Homo sapiens] 290 4e-78
gi|28872814 semaphorin 4G [Homo sapiens] 282 1e-75
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 277 2e-74
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 261 2e-69
gi|19923279 semaphorin W [Homo sapiens] 259 9e-69
gi|16306552 semaphorin Y [Homo sapiens] 258 1e-68
gi|19718780 semaphorin 6B precursor [Homo sapiens] 256 7e-68
gi|21361914 semaphorin B [Homo sapiens] 252 1e-66
gi|147904700 semaphorin 5A [Homo sapiens] 251 1e-66
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 251 2e-66
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 196 5e-50
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 193 6e-49
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 178 2e-44
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 1615 bits (4181), Expect = 0.0
Identities = 775/775 (100%), Positives = 775/775 (100%)
Query: 1 MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHT 60
MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHT
Sbjct: 1 MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHT 60
Query: 61 MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVR 120
MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVR
Sbjct: 61 MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVR 120
Query: 121 VLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFIS 180
VLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFIS
Sbjct: 121 VLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFIS 180
Query: 181 TLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRD 240
TLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRD
Sbjct: 181 TLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRD 240
Query: 241 DNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMN 300
DNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMN
Sbjct: 241 DNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMN 300
Query: 301 GIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHK 360
GIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHK
Sbjct: 301 GIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHK 360
Query: 361 EGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHK 420
EGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHK
Sbjct: 361 EGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHK 420
Query: 421 KPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILE 480
KPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILE
Sbjct: 421 KPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILE 480
Query: 481 ELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWD 540
ELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWD
Sbjct: 481 ELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWD 540
Query: 541 GISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLL 600
GISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLL
Sbjct: 541 GISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLL 600
Query: 601 ECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHS 660
ECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHS
Sbjct: 601 ECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHS 660
Query: 661 FVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYS 720
FVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYS
Sbjct: 661 FVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYS 720
Query: 721 NFQRVEEYCEKVWCTDRKRKKLKMSPSKWKYANPQEKKLRSKPEHYRLPRHTLDS 775
NFQRVEEYCEKVWCTDRKRKKLKMSPSKWKYANPQEKKLRSKPEHYRLPRHTLDS
Sbjct: 721 NFQRVEEYCEKVWCTDRKRKKLKMSPSKWKYANPQEKKLRSKPEHYRLPRHTLDS 775
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 786 bits (2029), Expect = 0.0
Identities = 373/770 (48%), Positives = 519/770 (67%), Gaps = 14/770 (1%)
Query: 8 ITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQ 67
I L WG LL PRL+LS+KE+L N F+ HT LLDE +
Sbjct: 7 IVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER 66
Query: 68 ERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDA-GECANYVRVLHHYN 126
RL+VG +D ++S L I D +++I WP + + +EC GKD ECAN+++VL YN
Sbjct: 67 SRLYVGAKDHIFSFDLVNIKD-FQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYN 125
Query: 127 RTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSE 186
+THL CGTGAF P+C +I +G+H ED +F LE+ E GRG+ P+DP S LI E
Sbjct: 126 QTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGE 185
Query: 187 LFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYF 246
L++G +D+ RD AIFR++G IRTE D R L +PKF+ +++I ++++ +D+KVYF
Sbjct: 186 LYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYF 245
Query: 247 FFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYF 306
FF E A++ E++ A + R+G++C ND GG R LVNKW+TFLKARL+CSVPG NGIDT+F
Sbjct: 246 FFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHF 305
Query: 307 DELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYH 366
DEL+DVFL+ +D KNPV++G+F T+SNIF+G A+C+Y MS +R F GPYAH++GP Y
Sbjct: 306 DELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQ 365
Query: 367 WSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVK 426
W Y+G+VPYPRPG+C SK GG + +TKD PDD I FARSHP MY + P + +PI++K
Sbjct: 366 WVPYQGRVPYPRPGTCPSKTFGG-FDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIK 424
Query: 427 TDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFK 486
TD Y QI VDRV+AEDGQYDV+FIGTD G VLKV++I + +EEV+LEE+ +F+
Sbjct: 425 TDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFR 484
Query: 487 DPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSR 546
+P I +ME+S+K+QQLYIGS + VAQ+ H CD+YG ACA+CCLARDPYCAWDG +CSR
Sbjct: 485 EPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSR 544
Query: 547 YYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRS 606
Y+PT AKRR RRQD+R+G+ C EE + YG+EN+ST LEC+P+S
Sbjct: 545 YFPT---AKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKS 601
Query: 607 LQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVR 666
+A V W Q+ E RKEE++ DD +++ D GLL L + D+G Y C VEH F+ T+
Sbjct: 602 QRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLL 661
Query: 667 KITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVE 726
K+TLEV++ E +E++ +KDD+ D +S++ K WY++F+QLI + N ++
Sbjct: 662 KVTLEVIDTEHLEELLHKDDDGDGSKTK--EMSNSMTPSQKVWYRDFMQLINHPNLNTMD 719
Query: 727 EYCEKVWCTDRKRKKLKM-----SPSKWKYANPQEK-KLRSKPEHYRLPR 770
E+CE+VW DRK+++ + + +KWK+ +K + R E R PR
Sbjct: 720 EFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPR 769
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 771 bits (1992), Expect = 0.0
Identities = 395/786 (50%), Positives = 525/786 (66%), Gaps = 25/786 (3%)
Query: 1 MASAGHIITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHT 60
MA + I LL G LL + G + + PRLRLS+++LL+ NR++IF P G L+L
Sbjct: 1 MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA 60
Query: 61 MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDA-GECANYV 119
M LDEY++RLF+GG D +YSL L++ +E+ WP + EEC+ KG+D ECAN+V
Sbjct: 61 MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV 120
Query: 120 RVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFI 179
RVL +NRTHLL CGTGAF P CA I VG H + + HLE E GRGRCP +PS F
Sbjct: 121 RVLQPHNRTHLLACGTGAFQPTCALITVG-HRGEHVLHLEPGSVESGRGRCPHEPSRPFA 179
Query: 180 STLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDR 239
ST I EL+ GL +D+ R+A IFRS G +R++ D+ LL +P+FV + IP+N D+
Sbjct: 180 STFIDGELYTGLTADFLGREAMIFRSGGPRPALRSD-SDQSLLHDPRFVMAARIPENSDQ 238
Query: 240 DDNKVYFFFTEKALEAENNA-HAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPG 298
D++KVYFFF+E + + H +RVGR+CVND GGQR+LVNKWSTFLKARLVCSVPG
Sbjct: 239 DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPG 298
Query: 299 MNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYA 358
G +T+FD+LEDVFLL + K+ ++ LF+T S +F+G A+CVYHM+ I FNGP+A
Sbjct: 299 PGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFA 358
Query: 359 HKEGPEYHWSVYEGKVPYPRPGSCASKVN---GGRYGTTKDYPDDAIRFARSHPLMYQAI 415
H++GP++ W Y GKVP+PRPG C SK+ G +G+TKDYPD+ ++FAR+HPLM+ +
Sbjct: 359 HRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPV 418
Query: 416 KPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESME 475
+P H +P+LVKT L QI VDRVEAEDG YDV+F+GTD+G VLKVI + E
Sbjct: 419 RPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPE 478
Query: 476 EVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDP 535
EV+LEELQ+FK P PI MEIS KRQ LY+GS VAQ+R H C+ YG+ACA+CCLARDP
Sbjct: 479 EVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDP 538
Query: 536 YCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIEN 595
YCAWDG SC+ Y P + KRRFRRQD+RHGN A QC GQ +A+ + YG E+
Sbjct: 539 YCAWDGASCTHYRP--SLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEH 596
Query: 596 NSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQ 655
NST LEC P+S QA V W +Q+ + ++VKTD+RV+ + GLLF RL + DAGTY C
Sbjct: 597 NSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCT 656
Query: 656 TVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSI-SQGAKPWYKEFL 714
T+EH F TV ++ L V+ +++++F + + + PA+ + S K WYK+ L
Sbjct: 657 TLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEP-----PARGGLASTPPKAWYKDIL 711
Query: 715 QLIGYSNFQRVEEYCEKVWCTD--------RKRKKLKMSPSKWKYANPQEKKLRSK--PE 764
QLIG++N RV+EYCE+VWC R R + K + K KK++S+ E
Sbjct: 712 QLIGFANLPRVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAE 771
Query: 765 HYRLPR 770
H R PR
Sbjct: 772 HNRTPR 777
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 718 bits (1853), Expect = 0.0
Identities = 350/750 (46%), Positives = 505/750 (67%), Gaps = 29/750 (3%)
Query: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY 90
PRL+L++K+LL N F LD T+LLDE + RL +G +D ++ LSL ++ +
Sbjct: 43 PRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF 102
Query: 91 KEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGY 149
K+I+WP+ ++E C + GKDA ECAN++RVL YN+TH+ CGTGAF P+C +I +G
Sbjct: 103 KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGV 162
Query: 150 HLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRL 209
+ ED +F L++ E GR +CPFDP F S + L++G SD+ +D A RS+G
Sbjct: 163 YKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPT 222
Query: 210 A---HIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRV 266
+IRT+ + L KF+G++ IPD + DD+K+YFFF E + E + I +RV
Sbjct: 223 HDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRV 282
Query: 267 GRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIF 326
GR+C NDVGGQR L+NKW+TFLKARL+CS+PG +G DTYFDEL+D++LLPTRD +NPV++
Sbjct: 283 GRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVY 342
Query: 327 GLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKV 386
G+F TTS+IF+G A+CVY M+ IRA FNGPYAHKE ++ W Y+G++PYPRPG+C SK
Sbjct: 343 GVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKT 402
Query: 387 NGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDG 446
+T+D+PDD I F + H +MY+++ P P + + Y L QI VD V AEDG
Sbjct: 403 YDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDG 462
Query: 447 QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIG 506
QYDV+F+GTD G VLKV++I ++E +MEEV+LEELQIFK I++ME+S K+QQLYIG
Sbjct: 463 QYDVMFLGTDIGTVLKVVSI-SKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIG 521
Query: 507 SASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHG 566
S + Q+ H CD YG ACADCCLARDPYCAWDG +CSRY PT +KRR RRQDV++G
Sbjct: 522 SRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPT---SKRRARRQDVKYG 578
Query: 567 NAAQQCFGQQFVGDAL--DKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKE 624
+ QC+ + D++ + +E + +GIE NST LEC P+S QA + W++Q+ + +E
Sbjct: 579 DPITQCWD---IEDSISHETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHRE 635
Query: 625 EVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNK 684
E+K D+R++K + GLL L K D+G Y+C+ EH+F+HT+ K+TL V+E E++E+
Sbjct: 636 ELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRA 695
Query: 685 DDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDRKRKKLKM 744
+ EE + + ++ YK+++Q++ NF +++YCE++W +++R++ K
Sbjct: 696 EHEEGK--------VKDLLAESRLRYKDYIQILSSPNFS-LDQYCEQMWHREKRRQRNKG 746
Query: 745 SPSKWKYANPQEKKLRSKPEHYR----LPR 770
P KWK+ QE K + H+R LPR
Sbjct: 747 GP-KWKHM--QEMKKKRNRRHHRDLDELPR 773
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 667 bits (1720), Expect = 0.0
Identities = 339/710 (47%), Positives = 461/710 (64%), Gaps = 40/710 (5%)
Query: 19 LWTGG-HTADTTHPRLRLSHKEL--------LNLNRTSIFHSPFGFLDLHTMLLDEYQER 69
LW G +A + PRLRLS +EL +L RT + + +L+DE + R
Sbjct: 16 LWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQA---------LLVDEERGR 66
Query: 70 LFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRT 128
LFVG + V SL+L+ IS K++ WP+ EEC GKD G EC N+V++LH YNRT
Sbjct: 67 LFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRT 126
Query: 129 HLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELF 188
HLL CGTGAF P CAF+ VG+ E+P+ L+ R E G+G+ P+DP S L+G EL+
Sbjct: 127 HLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELY 186
Query: 189 AGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFF 248
+G+ +D RD IFRS+G+ +RTE D R L EPKFV + IP++E+ DD+K+YFFF
Sbjct: 187 SGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFF 246
Query: 249 TEKALEAENNAHAI-YTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFD 307
E A+EA + +RVG++C NDVGGQR LVNKW+TFLKARLVCSVPG+ G DT+FD
Sbjct: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFD 305
Query: 308 ELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW 367
+L+DVFLL +RDH+ P+++ +F+T+S+IF+G A+CVY M+ +R AF GP+AHKEGP + W
Sbjct: 306 QLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQW 365
Query: 368 SVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKT 427
Y+G+VPYPRPG C SK G + +TKD+PDD I+FAR+HPLMY ++ P +P+ ++
Sbjct: 366 VSYQGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 424
Query: 428 DGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKD 487
Y QIA DRV A DG YDVLFIGTD G VLKVI++ S E ++LEEL +F+D
Sbjct: 425 GANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED 484
Query: 488 PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRY 547
+ SM+ISSKR QLY+ S SAVAQ+ H C +G C +CCLARDPYCAWDG++C+R+
Sbjct: 485 SAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRF 544
Query: 548 YPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSL 607
P+ AKRRFRRQDVR+G+ + C G L EH +G+E +S LEC PRSL
Sbjct: 545 QPS---AKRRFRRQDVRNGDPSTLCSGDSSRPALL----EHKVFGVEGSSAFLECEPRSL 597
Query: 608 QAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRK 667
QA+V W Q+ T +V ++R + GLL RL + D+G Y C VE F +R+
Sbjct: 598 QARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRR 657
Query: 668 ITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLI 717
++L V+ + E + ++ A + G K WY++FLQL+
Sbjct: 658 LSLHVLSATQAERLARAEE-----------AAPAAPPGPKLWYRDFLQLV 696
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 663 bits (1710), Expect = 0.0
Identities = 344/795 (43%), Positives = 478/795 (60%), Gaps = 58/795 (7%)
Query: 10 LLLWGYLLE-LWTGGHTAD--TTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEY 66
LLLW LL W T D PR+RLS KEL F+ D +L DE
Sbjct: 6 LLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDED 65
Query: 67 QERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDA-GECANYVRVLHHY 125
+R++VG +D V SL L I+ IHW ++ ++EEC++ GKD GEC N+VR++ +
Sbjct: 66 HDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPW 125
Query: 126 NRTHLLTCGTGAFDPVCAFIRVGYHL-------------------------------EDP 154
NRTHL CGTGA++P+C ++ G +D
Sbjct: 126 NRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDY 185
Query: 155 LFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRT 214
+F+LE R E G+G+CP+DP S LI EL+AG+Y D+ DAAIFR++G+ +RT
Sbjct: 186 IFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRT 245
Query: 215 EHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDV 274
+ + R L +P F+ + +IPD+ +R+D+K+YFFF E++ EA + A+Y R+GR+C+ND
Sbjct: 246 DQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSP-AVYARIGRICLNDD 304
Query: 275 GGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSN 334
GG LVNKWSTFLKARLVCSVPG +GI+T+FDEL+DVF+ T+D +NPVI+ +F ++ +
Sbjct: 305 GGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGS 364
Query: 335 IFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTT 394
+FRG A+CVY M+ IR FNGP+AHKEGP Y W + GK+PYPRPG+C +T
Sbjct: 365 VFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKST 424
Query: 395 KDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIG 454
KDYPD+ I F RSHPLMYQA+ P ++P++V+T Y L IAVD+V+A DG+Y+VLF+G
Sbjct: 425 KDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLG 484
Query: 455 TDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQV 514
TD G V KVI + + E +EE++LEE+++FKDP P+ +M ISSKRQQLY+ SA V +
Sbjct: 485 TDRGTVQKVIVLPKDDQE-LEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHL 543
Query: 515 RFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFG 574
H C YG+ACADCCLARDPYCAWDG +CSRY + +KRR RRQDVRHGN +QC G
Sbjct: 544 SLHRCQAYGAACADCCLARDPYCAWDGQACSRYTAS---SKRRSRRQDVRHGNPIRQCRG 600
Query: 575 QQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVK 634
F +A E + YG+ ++ LEC PRS QA V W Q+ R+ E++ +DR ++
Sbjct: 601 --FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLR 658
Query: 635 MDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRM 694
+ GLL L SD G Y C E++F H V ++ L V+ + V
Sbjct: 659 TEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFP---------- 708
Query: 695 PCPAQSSISQGA---KPWYKEFLQLIGYSNFQRVEEYCEKVWCTDRKRKKLKMSPSKWKY 751
P + GA P Y+E QL+ + +YC+ W + +P +
Sbjct: 709 PLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQGYW--RHVPPSPREAPGAPRS 766
Query: 752 ANPQ-EKKLRSKPEH 765
PQ +KK R++ H
Sbjct: 767 PEPQDQKKPRNRRHH 781
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 662 bits (1707), Expect = 0.0
Identities = 339/710 (47%), Positives = 460/710 (64%), Gaps = 41/710 (5%)
Query: 19 LWTGG-HTADTTHPRLRLSHKEL--------LNLNRTSIFHSPFGFLDLHTMLLDEYQER 69
LW G +A + PRLRLS +EL +L RT + + +L+DE + R
Sbjct: 16 LWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQA---------LLVDEERGR 66
Query: 70 LFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRT 128
LFVG + V SL+L+ IS K++ WP+ EEC GKD G EC N+V++LH YNRT
Sbjct: 67 LFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRT 126
Query: 129 HLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELF 188
HLL CGTGAF P CAF+ VG+ E+P+ L+ R E G+G+ P+DP S L+G EL+
Sbjct: 127 HLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELY 186
Query: 189 AGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFF 248
+G+ +D RD IFRS+G+ +RTE D R L EPKFV + IP++E+ DD+K+YFFF
Sbjct: 187 SGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFF 246
Query: 249 TEKALEAENNAHAI-YTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFD 307
E A+EA + +RVG++C NDVGGQR LVNKW+TFLKARLVCSVPG+ G DT+FD
Sbjct: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFD 305
Query: 308 ELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW 367
+L+DVFLL +RDH+ P+++ +F+T+S IF+G A+CVY M+ +R AF GP+AHKEGP + W
Sbjct: 306 QLQDVFLLSSRDHRTPLLYAVFSTSS-IFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQW 364
Query: 368 SVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKT 427
Y+G+VPYPRPG C SK G + +TKD+PDD I+FAR+HPLMY ++ P +P+ ++
Sbjct: 365 VSYQGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 423
Query: 428 DGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKD 487
Y QIA DRV A DG YDVLFIGTD G VLKVI++ S E ++LEEL +F+D
Sbjct: 424 GANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED 483
Query: 488 PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRY 547
+ SM+ISSKR QLY+ S SAVAQ+ H C +G C +CCLARDPYCAWDG++C+R+
Sbjct: 484 SAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRF 543
Query: 548 YPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSL 607
P+ AKRRFRRQDVR+G+ + C G L EH +G+E +S LEC PRSL
Sbjct: 544 QPS---AKRRFRRQDVRNGDPSTLCSGDSSRPALL----EHKVFGVEGSSAFLECEPRSL 596
Query: 608 QAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRK 667
QA+V W Q+ T +V ++R + GLL RL + D+G Y C VE F +R+
Sbjct: 597 QARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRR 656
Query: 668 ITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLI 717
++L V+ + E + ++ A + G K WY++FLQL+
Sbjct: 657 LSLHVLSATQAERLARAEE-----------AAPAAPPGPKLWYRDFLQLV 695
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 648 bits (1671), Expect = 0.0
Identities = 322/701 (45%), Positives = 453/701 (64%), Gaps = 20/701 (2%)
Query: 32 RLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYK 91
R+ L+ EL + F LD +L+DE Q+R++VG +D + SL++ IS
Sbjct: 28 RVYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEAL 87
Query: 92 EIHWPSTALKMEECIMKGKDAGE-CANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYH 150
+ WP++ +K+EEC M GKD C N+VRV+ +NRTHL CG+GAF PVC ++ G
Sbjct: 88 SVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRR 147
Query: 151 LEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLA 210
ED +F ++S + E G+GRC F+P+ + +S +I ELF+G+Y D+ DAAIFRS+ +
Sbjct: 148 SEDQVFMIDS-KCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRN 206
Query: 211 HIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLC 270
+RT+ + + L EP FV +++IPD D +D KVYFFF EK + + I++ + R+C
Sbjct: 207 AVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARIC 266
Query: 271 VNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFN 330
ND GG R LVNKW+TFLKARLVCSV +G +T+FDELEDVFLL T + + +++G+F
Sbjct: 267 PNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFT 326
Query: 331 TTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGR 390
T+S++F+G A+CVYH+S I+ FNGP+AHKEGP + Y+G++PYPRPG+C
Sbjct: 327 TSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPN 386
Query: 391 YGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDV 450
TTK++PDD + F R+HPLMY +I P HK+P++V+ Y +IAVDRV A DG+Y V
Sbjct: 387 MRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGRYHV 446
Query: 451 LFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASA 510
LF+GTD G V KV+ + S E+ILEEL++FK+ PI +M+ISSK+QQLY+ S
Sbjct: 447 LFLGTDRGTVQKVVVLPTNNSVS-GELILEELEVFKNHAPITTMKISSKKQQLYVSSNEG 505
Query: 511 VAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQ 570
V+QV H C +YG+ACADCCLARDPYCAWDG SCSR+YPTG KRR RRQDVRHGN
Sbjct: 506 VSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTG---KRRSRRQDVRHGNPLT 562
Query: 571 QCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDD 630
QC G F A E + YG++NN+T LEC P+S QA + W +QK ++ RK EVK ++
Sbjct: 563 QCRG--FNLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQKDKDRRK-EVKLNE 619
Query: 631 RVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDR 690
R++ GLL + SD G Y C E+SF T+ KI +V++ E V + +K
Sbjct: 620 RIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWS---- 675
Query: 691 HHRMPCPAQSSISQGAKPWY-KEFLQLIGYSNFQRVEEYCE 730
P + S A P++ K+ + +S Q + +YC+
Sbjct: 676 ------PWTWASSVRALPFHPKDIMGAFSHSEMQMINQYCK 710
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 322 bits (825), Expect = 8e-88
Identities = 224/660 (33%), Positives = 331/660 (50%), Gaps = 51/660 (7%)
Query: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY 90
PR+ H+E+ + FH P + +LL E ++ L++G R+ V++++ IS+
Sbjct: 28 PRITWEHREVHLVQ----FHEP-DIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82
Query: 91 KEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGY 149
E++W + K +C KGK EC NY+RVL + T L CGT AF P C
Sbjct: 83 HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACD------ 136
Query: 150 HLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRL 209
HL F ++E G+GRCPFDP+ S+ S ++ EL++G ++ + I R+
Sbjct: 137 HLNLTSFKFLG-KNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSH- 194
Query: 210 AHIRTEHDDERLLKEPKFVGSYMI---PDNEDRDDNKVYFFFTEKALEAENNAHAIYTRV 266
+ +RTE+ L EP FV + +I PD+ D +D++VYFFFTE ++E E + R+
Sbjct: 195 SPLRTEYAIP-WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253
Query: 267 GRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIF 326
R+C D GG R L KW++FLKARL+CS P + F+ L DVF+L + K PV +
Sbjct: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFY 310
Query: 327 GLFNTTSNIFRGHAICVYHMSSIRAAF-NGPYAHK---EGPEYHWSVYEGKVPYPRPGSC 382
LF N A+C Y++S+ F +G Y E W Y G VP PRPG+C
Sbjct: 311 ALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGAC 370
Query: 383 A-SKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRV 441
S+ Y ++ + PD ++F + HPLM ++ P +P L+K D Y QI VDR
Sbjct: 371 IDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYT--QIVVDRT 428
Query: 442 EAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKR 500
+A DG YDV+F+ TD G + K I++ + I+EE Q+F+D P+ ++ +SSK+
Sbjct: 429 QALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSKK 482
Query: 501 --QQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRF 558
+ +Y GS S V Q C +G+ C DC LARDPYCAW PT T
Sbjct: 483 GNRFVYAGSNSGVVQAPLAFCGKHGT-CEDCVLARDPYCAWSP-------PTATCVALHQ 534
Query: 559 RRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKG 618
R Q+ G V K + + L+C+ +S A+V W Q G
Sbjct: 535 TESPSR--GLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNG 592
Query: 619 RETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKV 678
+ E K K LL L + D+G Y C + E TV ++ + V E KV
Sbjct: 593 -VLKAESPKYGLMGRK---NLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKV 648
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 315 bits (807), Expect = 1e-85
Identities = 198/552 (35%), Positives = 285/552 (51%), Gaps = 34/552 (6%)
Query: 12 LWGYLLELWTGGHTADTTH---PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQE 68
+W LW G A+ PR +S EL + R S G D T+ L E
Sbjct: 7 VWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRR---FSQTGIQDFLTLTLTEPTG 63
Query: 69 RLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKD-AGECANYVRVLHHYNR 127
L+VG R+ +++ S+E + + I W + K ECI KGK+ EC N++R L YN
Sbjct: 64 LLYVGAREALFAFSMEAL-ELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNA 122
Query: 128 THLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSEL 187
+HL CGT AF P C ++ + F LE E G+G+CP+DP+ L+ EL
Sbjct: 123 SHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGEL 176
Query: 188 FAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDR---DDNKV 244
++ +++ + I R+MG ++TE+ L EP FVGS +P++ DD+KV
Sbjct: 177 YSATLNNFLGTEPIILRNMGPHHSMKTEYL-AFWLNEPHFVGSAYVPESVGSFTGDDDKV 235
Query: 245 YFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDT 304
YFFF E+A+E++ A + RV R+C D+GG R L KW+TFLKARL CS P
Sbjct: 236 YFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNW---QL 292
Query: 305 YFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPE 364
YF++L+ + L N FG+F AIC Y + I+ F GPY
Sbjct: 293 YFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEA 352
Query: 365 YHWSVYEGKVPYPRPGSCASKVNGGR-YGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPI 423
W Y VP PRPGSC + + Y ++ + PD+ + F + HPLM + + P +P+
Sbjct: 353 QKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPL 412
Query: 424 LVKTDGKYNLKQIAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEEL 482
LVK N + DRV DG Y VLFIGT +G +LK +++ ++EEL
Sbjct: 413 LVKKG--TNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSL------GPWVHLIEEL 464
Query: 483 QIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGI 542
Q+F D P+ S+ +S ++ L+ GS S + Q+ C Y S CADC LARDPYCAW +
Sbjct: 465 QLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRS-CADCVLARDPYCAW-SV 521
Query: 543 SCSRYYPTGTHA 554
+ SR G H+
Sbjct: 522 NTSRCVAVGGHS 533
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 309 bits (791), Expect = 7e-84
Identities = 191/521 (36%), Positives = 284/521 (54%), Gaps = 38/521 (7%)
Query: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY 90
PR+ H+E+ + FH P + +LL E ++ L++G R+ V++++ IS+
Sbjct: 28 PRITWEHREVHLVQ----FHEP-DIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82
Query: 91 KEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGY 149
E++W + K +C KGK EC NY+RVL + T L CGT AF P C
Sbjct: 83 HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACD------ 136
Query: 150 HLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRL 209
HL F ++E G+GRCPFDP+ S+ S ++ EL++G ++ + I R+
Sbjct: 137 HLNLTSFKFLG-KNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSH- 194
Query: 210 AHIRTEHDDERLLKEPKFVGSYMI---PDNEDRDDNKVYFFFTEKALEAENNAHAIYTRV 266
+ +RTE+ L EP FV + +I PD+ D +D++VYFFFTE ++E E + R+
Sbjct: 195 SPLRTEYAIP-WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253
Query: 267 GRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIF 326
R+C D GG R L KW++FLKARL+CS P + F+ L DVF+L + K PV +
Sbjct: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFY 310
Query: 327 GLFNTTSNIFRGHAICVYHMSSIRAAF-NGPYAHK---EGPEYHWSVYEGKVPYPRPGSC 382
LF N A+C Y++S+ F +G Y E W Y G VP PRPG+C
Sbjct: 311 ALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGAC 370
Query: 383 A-SKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRV 441
S+ Y ++ + PD ++F + HPLM ++ P +P L+K D Y QI VDR
Sbjct: 371 IDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYT--QIVVDRT 428
Query: 442 EAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKR 500
+A DG YDV+F+ TD G + K I++ + I+EE Q+F+D P+ ++ +SSK+
Sbjct: 429 QALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSKK 482
Query: 501 --QQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAW 539
+ +Y GS S V Q C +G+ C DC LARDPYCAW
Sbjct: 483 GNRFVYAGSNSGVVQAPLAFCGKHGT-CEDCVLARDPYCAW 522
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 299 bits (765), Expect = 8e-81
Identities = 186/538 (34%), Positives = 277/538 (51%), Gaps = 43/538 (7%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY----KEIHWPSTALKMEECIMKGKD 111
LD ML + ++ L++ GRD VY+++L + K++ W S E C MKGK
Sbjct: 57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH 114
Query: 112 AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRC 170
EC N+++V N + CGT AF+P+C + R L LE E G RC
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR--------LSTLEYDGEEISGLARC 166
Query: 171 PFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGS 230
PFD + ++ +L++ +D+ + DA I+RSMG + +RT D + +KEP F+ +
Sbjct: 167 PFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226
Query: 231 YMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLK 289
N VYFFF E A+E N A+Y+RV R+C ND+GG QR+L W++FLK
Sbjct: 227 IEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLK 279
Query: 290 ARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSI 349
ARL CSVPG + YFD L+ + + + + P + G+F T N G A+C + M I
Sbjct: 280 ARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDI 336
Query: 350 RAAFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSH 408
F G + ++ P+ W+ V E KVP PRPG CA Y T+ D+PD+ + F +SH
Sbjct: 337 EKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSH 396
Query: 409 PLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYN 468
PLM A+ P +P KT +Y L I+VD Y V+F+G++ G+VLKV+
Sbjct: 397 PLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA-KT 455
Query: 469 QEMESMEEVILEELQIF---------KDPVPIISMEISSKRQQLYIGSASAVAQVRFHHC 519
+ V+LEE++ + ++ +IS+++ LY+ +S + ++ C
Sbjct: 456 SPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Query: 520 DMYGSACADCCLARDPYCAW-DGISCSRYYPTGTHAKRRFRRQDVRHGNAAQ--QCFG 574
+ YGS C +RDPYC W SC R P G A+ QD GN A C G
Sbjct: 516 ERYGSCKKSCIASRDPYCGWLSQGSCGRVTP-GMLAEG--YEQDTEFGNTAHLGDCHG 570
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 298 bits (764), Expect = 1e-80
Identities = 184/531 (34%), Positives = 275/531 (51%), Gaps = 41/531 (7%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY----KEIHWPSTALKMEECIMKGKD 111
LD ML + ++ L++ GRD VY+++L + K++ W S E C MKGK
Sbjct: 57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH 114
Query: 112 AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRC 170
EC N+++V N + CGT AF+P+C + R L LE E G RC
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR--------LSTLEYDGEEISGLARC 166
Query: 171 PFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGS 230
PFD + ++ +L++ +D+ + DA I+RSMG + +RT D + +KEP F+ +
Sbjct: 167 PFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226
Query: 231 YMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLK 289
N VYFFF E A+E N A+Y+RV R+C ND+GG QR+L W++FLK
Sbjct: 227 IEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLK 279
Query: 290 ARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSI 349
ARL CSVPG + YFD L+ + + + + P + G+F T N G A+C + M I
Sbjct: 280 ARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDI 336
Query: 350 RAAFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSH 408
F G + ++ P+ W+ V E KVP PRPG CA Y T+ D+PD+ + F +SH
Sbjct: 337 EKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSH 396
Query: 409 PLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYN 468
PLM A+ P +P KT +Y L I+VD Y V+F+G++ G+VLKV+
Sbjct: 397 PLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA-KT 455
Query: 469 QEMESMEEVILEELQIF---------KDPVPIISMEISSKRQQLYIGSASAVAQVRFHHC 519
+ V+LEE++ + ++ +IS+++ LY+ +S + ++ C
Sbjct: 456 SPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Query: 520 DMYGSACADCCLARDPYCAW-DGISCSRYYPTGTHAKRRFRRQDVRHGNAA 569
+ YGS C +RDPYC W SC R P G A+ QD GN A
Sbjct: 516 ERYGSCKKSCIASRDPYCGWLSQGSCGRVTP-GMLAEG--YEQDTEFGNTA 563
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 298 bits (764), Expect = 1e-80
Identities = 184/531 (34%), Positives = 275/531 (51%), Gaps = 41/531 (7%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY----KEIHWPSTALKMEECIMKGKD 111
LD ML + ++ L++ GRD VY+++L + K++ W S E C MKGK
Sbjct: 57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH 114
Query: 112 AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRC 170
EC N+++V N + CGT AF+P+C + R L LE E G RC
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR--------LSTLEYDGEEISGLARC 166
Query: 171 PFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGS 230
PFD + ++ +L++ +D+ + DA I+RSMG + +RT D + +KEP F+ +
Sbjct: 167 PFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226
Query: 231 YMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLK 289
N VYFFF E A+E N A+Y+RV R+C ND+GG QR+L W++FLK
Sbjct: 227 IEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLK 279
Query: 290 ARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSI 349
ARL CSVPG + YFD L+ + + + + P + G+F T N G A+C + M I
Sbjct: 280 ARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDI 336
Query: 350 RAAFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSH 408
F G + ++ P+ W+ V E KVP PRPG CA Y T+ D+PD+ + F +SH
Sbjct: 337 EKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSH 396
Query: 409 PLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYN 468
PLM A+ P +P KT +Y L I+VD Y V+F+G++ G+VLKV+
Sbjct: 397 PLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA-KT 455
Query: 469 QEMESMEEVILEELQIF---------KDPVPIISMEISSKRQQLYIGSASAVAQVRFHHC 519
+ V+LEE++ + ++ +IS+++ LY+ +S + ++ C
Sbjct: 456 SPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Query: 520 DMYGSACADCCLARDPYCAW-DGISCSRYYPTGTHAKRRFRRQDVRHGNAA 569
+ YGS C +RDPYC W SC R P G A+ QD GN A
Sbjct: 516 ERYGSCKKSCIASRDPYCGWLSQGSCGRVTP-GMLAEG--YEQDTEFGNTA 563
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 298 bits (764), Expect = 1e-80
Identities = 184/531 (34%), Positives = 275/531 (51%), Gaps = 41/531 (7%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY----KEIHWPSTALKMEECIMKGKD 111
LD ML + ++ L++ GRD VY+++L + K++ W S E C MKGK
Sbjct: 57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH 114
Query: 112 AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRC 170
EC N+++V N + CGT AF+P+C + R L LE E G RC
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR--------LSTLEYDGEEISGLARC 166
Query: 171 PFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGS 230
PFD + ++ +L++ +D+ + DA I+RSMG + +RT D + +KEP F+ +
Sbjct: 167 PFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226
Query: 231 YMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLK 289
N VYFFF E A+E N A+Y+RV R+C ND+GG QR+L W++FLK
Sbjct: 227 IEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLK 279
Query: 290 ARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSI 349
ARL CSVPG + YFD L+ + + + + P + G+F T N G A+C + M I
Sbjct: 280 ARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDI 336
Query: 350 RAAFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSH 408
F G + ++ P+ W+ V E KVP PRPG CA Y T+ D+PD+ + F +SH
Sbjct: 337 EKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSH 396
Query: 409 PLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYN 468
PLM A+ P +P KT +Y L I+VD Y V+F+G++ G+VLKV+
Sbjct: 397 PLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA-KT 455
Query: 469 QEMESMEEVILEELQIF---------KDPVPIISMEISSKRQQLYIGSASAVAQVRFHHC 519
+ V+LEE++ + ++ +IS+++ LY+ +S + ++ C
Sbjct: 456 SPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Query: 520 DMYGSACADCCLARDPYCAW-DGISCSRYYPTGTHAKRRFRRQDVRHGNAA 569
+ YGS C +RDPYC W SC R P G A+ QD GN A
Sbjct: 516 ERYGSCKKSCIASRDPYCGWLSQGSCGRVTP-GMLAEG--YEQDTEFGNTA 563
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 297 bits (760), Expect = 3e-80
Identities = 177/511 (34%), Positives = 267/511 (52%), Gaps = 38/511 (7%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY----KEIHWPSTALKMEECIMKGKD 111
LD ML + ++ L++ GRD VY+++L + K++ W S E C MKGK
Sbjct: 57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH 114
Query: 112 AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRC 170
EC N+++V N + CGT AF+P+C + R L LE E G RC
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR--------LSTLEYDGEEISGLARC 166
Query: 171 PFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGS 230
PFD + ++ +L++ +D+ + DA I+RSMG + +RT D + +KEP F+ +
Sbjct: 167 PFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226
Query: 231 YMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLK 289
N VYFFF E A+E N A+Y+RV R+C ND+GG QR+L W++FLK
Sbjct: 227 IEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLK 279
Query: 290 ARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSI 349
ARL CSVPG + YFD L+ + + + + P + G+F T N G A+C + M I
Sbjct: 280 ARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDI 336
Query: 350 RAAFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSH 408
F G + ++ P+ W+ V E KVP PRPG CA Y T+ D+PD+ + F +SH
Sbjct: 337 EKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSH 396
Query: 409 PLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYN 468
PLM A+ P +P KT +Y L I+VD Y V+F+G++ G+VLKV+
Sbjct: 397 PLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA-KT 455
Query: 469 QEMESMEEVILEELQIF---------KDPVPIISMEISSKRQQLYIGSASAVAQVRFHHC 519
+ V+LEE++ + ++ +IS+++ LY+ +S + ++ C
Sbjct: 456 SPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Query: 520 DMYGSACADCCLARDPYCAW-DGISCSRYYP 549
+ YGS C +RDPYC W SC R P
Sbjct: 516 ERYGSCKKSCIASRDPYCGWLSQGSCGRVTP 546
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 290 bits (742), Expect = 4e-78
Identities = 212/676 (31%), Positives = 327/676 (48%), Gaps = 51/676 (7%)
Query: 61 MLLDEYQERLFVGGRDLVYSLS--LERISDG-YKEIHWPSTALKMEECIMKGKDAG-ECA 116
+LL L+VG R+ +++LS L + G Y+E+ W + A K ++C KGKD +C
Sbjct: 73 LLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQ 132
Query: 117 NYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRS---ERGRGRCPFD 173
NY+++L + +HL TCGT AF P+C +I ++E+ + + E G+GRCPFD
Sbjct: 133 NYIKILLPLSGSHLFTCGTAAFSPMCTYI----NMENFTLARDEKGNVLLEDGKGRCPFD 188
Query: 174 PSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMI 233
P+ + ++ EL+ G S + D AI RS L +TE L++P FV S I
Sbjct: 189 PNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTE-SSLNWLQDPAFVASAYI 246
Query: 234 PDNEDR---DDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKA 290
P++ DD+K+YFFF+E E E + I +R+ R+C D GG+R+L +W++FLKA
Sbjct: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
Query: 291 RLVCSVPGMNGIDTYFDELEDVFLL--PTRDHKNPVIFGLFNTT--SNIFRGHAICVYHM 346
+L+CS P +G F+ L+DVF L +D ++ + +G+F + G A+CV+ M
Sbjct: 307 QLLCSRPD-DGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
Query: 347 SSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSC-ASKVNGGRYGTTKDYPDDAIRFA 405
++ F+G Y W VP PRPG+C + + ++ PD + F
Sbjct: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
Query: 406 RSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVIT 465
+ H LM ++ + +L++ +Y +++AV RV YDVLF+GT +G + K ++
Sbjct: 424 KDHFLMDGQVR---SRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
Query: 466 IYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSA 525
+ I+EELQIF P+ ++ + + R LY S S V QV +C +Y S
Sbjct: 479 V------GPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRS- 531
Query: 526 CADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKT 585
C DC LARDPYCAW G SC R QD+ +A C V + T
Sbjct: 532 CGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPT 591
Query: 586 EEHLAYGIE---NNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFL 642
E ++ N L C S A +W V + G L L
Sbjct: 592 GEKPCEQVQFQPNTVNTLACPLLSNLATRLWL------RNGAPVNASASCHVLPTGDLLL 645
Query: 643 RLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEED---RHHRMPCPAQ 699
+ G + C ++E F V EVV E+ V D ++ R+ PA
Sbjct: 646 -VGTQQLGEFQCWSLEEGFQQLVASYCPEVV-EDGVADQTDEGGSVPVIISTSRVSAPAG 703
Query: 700 SSISQGA-KPWYKEFL 714
S GA + ++KEFL
Sbjct: 704 GKASWGADRSYWKEFL 719
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 290 bits (742), Expect = 4e-78
Identities = 212/676 (31%), Positives = 327/676 (48%), Gaps = 51/676 (7%)
Query: 61 MLLDEYQERLFVGGRDLVYSLS--LERISDG-YKEIHWPSTALKMEECIMKGKDAG-ECA 116
+LL L+VG R+ +++LS L + G Y+E+ W + A K ++C KGKD +C
Sbjct: 73 LLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQ 132
Query: 117 NYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRS---ERGRGRCPFD 173
NY+++L + +HL TCGT AF P+C +I ++E+ + + E G+GRCPFD
Sbjct: 133 NYIKILLPLSGSHLFTCGTAAFSPMCTYI----NMENFTLARDEKGNVLLEDGKGRCPFD 188
Query: 174 PSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMI 233
P+ + ++ EL+ G S + D AI RS L +TE L++P FV S I
Sbjct: 189 PNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTE-SSLNWLQDPAFVASAYI 246
Query: 234 PDNEDR---DDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKA 290
P++ DD+K+YFFF+E E E + I +R+ R+C D GG+R+L +W++FLKA
Sbjct: 247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKA 306
Query: 291 RLVCSVPGMNGIDTYFDELEDVFLL--PTRDHKNPVIFGLFNTT--SNIFRGHAICVYHM 346
+L+CS P +G F+ L+DVF L +D ++ + +G+F + G A+CV+ M
Sbjct: 307 QLLCSRPD-DGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTM 363
Query: 347 SSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSC-ASKVNGGRYGTTKDYPDDAIRFA 405
++ F+G Y W VP PRPG+C + + ++ PD + F
Sbjct: 364 KDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFL 423
Query: 406 RSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVIT 465
+ H LM ++ + +L++ +Y +++AV RV YDVLF+GT +G + K ++
Sbjct: 424 KDHFLMDGQVR---SRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVS 478
Query: 466 IYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSA 525
+ I+EELQIF P+ ++ + + R LY S S V QV +C +Y S
Sbjct: 479 V------GPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRS- 531
Query: 526 CADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKT 585
C DC LARDPYCAW G SC R QD+ +A C V + T
Sbjct: 532 CGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPT 591
Query: 586 EEHLAYGIE---NNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFL 642
E ++ N L C S A +W V + G L L
Sbjct: 592 GEKPCEQVQFQPNTVNTLACPLLSNLATRLWL------RNGAPVNASASCHVLPTGDLLL 645
Query: 643 RLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEED---RHHRMPCPAQ 699
+ G + C ++E F V EVV E+ V D ++ R+ PA
Sbjct: 646 -VGTQQLGEFQCWSLEEGFQQLVASYCPEVV-EDGVADQTDEGGSVPVIISTSRVSAPAG 703
Query: 700 SSISQGA-KPWYKEFL 714
S GA + ++KEFL
Sbjct: 704 GKASWGADRSYWKEFL 719
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 282 bits (721), Expect = 1e-75
Identities = 192/605 (31%), Positives = 289/605 (47%), Gaps = 56/605 (9%)
Query: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDG- 89
PR+ + ++EL H + T+LL+E RL VG R ++SLS I DG
Sbjct: 34 PRMTIPYEELSGTR-----HFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGA 88
Query: 90 YKEIHWPSTALKMEECIMKGKD-AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVG 148
+KEIHW ++ +C KGK+ EC N+VR L N THL CGT AF P+CA I
Sbjct: 89 HKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAI--- 145
Query: 149 YHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGR 208
+ F L + E G+ +CP+DP+ F +I L+ + Y R R
Sbjct: 146 ---DAEAFTLPTS-FEEGKEKCPYDPARGFTGLIIDGGLYTA--TRYEFRSIPDIRRSRH 199
Query: 209 LAHIRTEHDDERLLKEPKFVGSYMIPDNEDR---DDNKVYFFFTEKALEA-------ENN 258
+RTE L + +FV S ++ +++ DD+KVY+FFTE+A E +
Sbjct: 200 PHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRS 259
Query: 259 AHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTR 318
+H + RV R+C D+GG++IL KW++FLKARL+C +P ++ L V L
Sbjct: 260 SHRV-ARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-------LYETLRGVCSLDAE 311
Query: 319 DHKNPVIFGLF--NTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPY 376
+ F +T AIC Y ++ I+A F GPY + W YEG VP
Sbjct: 312 TSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPE 371
Query: 377 PRPGSC-ASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQ 435
PRPGSC + Y +++D P + F + HPLM + + P +P+L+K + +Y
Sbjct: 372 PRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYT--H 429
Query: 436 IAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISM 494
+ V G YD+LF+GT +G + K + + I+EE Q+F++ + ++
Sbjct: 430 LTGTPVTTPAGPTYDLLFLGTADGWIHKAVVL------GSGMHIIEETQVFRESQSVENL 483
Query: 495 EISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWD----GISCSRYYPT 550
IS + LY+G+ S V Q+ C Y S C DC LARDPYC WD + +
Sbjct: 484 VISLLQHSLYVGAPSGVIQLPLSSCSRYRS-CYDCILARDPYCGWDPGTHACAAATTIAN 542
Query: 551 GTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAK 610
+ R QD+ GN + C + G + G + LL C S A+
Sbjct: 543 RSQGSRTALIQDIERGN--RGCESSRDTGPPPPLKTRSVLRG---DDVLLPCDQPSNLAR 597
Query: 611 VIWFV 615
+W +
Sbjct: 598 ALWLL 602
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 277 bits (709), Expect = 2e-74
Identities = 167/519 (32%), Positives = 266/519 (51%), Gaps = 46/519 (8%)
Query: 70 LFVGGRDLVYSLSLE--RISDGY--KEIHWPSTALKMEECIMKGKDAGECANYVRVLHHY 125
L++ RD +Y++ ++ + Y K++ W S ++ C MKGK EC N+++VL
Sbjct: 68 LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKK 127
Query: 126 NRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRCPFDPSSSFISTLIG 184
N L CGT AF+P C Y ++ LE E G RCP+D + ++
Sbjct: 128 NDDALFVCGTNAFNPSCR----NYKMDT----LEPFGDEFSGMARCPYDAKHANVALFAD 179
Query: 185 SELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKV 244
+L++ +D+ + DA I+RS+G +RT D + LKEP FV + D +
Sbjct: 180 GKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDY-------I 232
Query: 245 YFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLKARLVCSVPGMNGID 303
YFFF E A+E ++ RV ++C ND+GG QR+L +W++FLKARL CSVPG +
Sbjct: 233 YFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHF- 291
Query: 304 TYFDELE---DVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHK 360
YF+ L+ DV + RD V+ F+T N G A+C Y M I + F G + +
Sbjct: 292 -YFNILQAVTDVIRINGRD----VVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQ 346
Query: 361 EGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAH 419
+ P+ W+ V + +VP PRPG CA + RY T+ ++PDD + F ++HPLM +A+
Sbjct: 347 KSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIF 406
Query: 420 KKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVIL 479
+P ++T +Y L +IAVD + V+F+G++ GI+LK + + + L
Sbjct: 407 NRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFL 466
Query: 480 EELQIFK---------DPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCC 530
EE+ ++ + I+ M++ LY+ ++ V +V C+ +G C
Sbjct: 467 EEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCI 526
Query: 531 LARDPYCAW--DGISCSRYYPTGTHAKRRFRRQDVRHGN 567
+RDPYC W +G +CS P R QD+ GN
Sbjct: 527 ASRDPYCGWIKEGGACSHLSPN----SRLTFEQDIERGN 561
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 261 bits (666), Expect = 2e-69
Identities = 157/437 (35%), Positives = 234/437 (53%), Gaps = 28/437 (6%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY----KEIHWPSTALKMEECIMKGKD 111
LD ML + ++ L++ GRD VY+++L + K++ W S E C MKGK
Sbjct: 57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH 114
Query: 112 AGECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRC 170
EC N+++V N + CGT AF+P+C + R L LE E G RC
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR--------LSTLEYDGEEISGLARC 166
Query: 171 PFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGS 230
PFD + ++ +L++ +D+ + DA I+RSMG + +RT D + +KEP F+ +
Sbjct: 167 PFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHA 226
Query: 231 YMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGG-QRILVNKWSTFLK 289
N VYFFF E A+E N A+Y+RV R+C ND+GG QR+L W++FLK
Sbjct: 227 IEY-------GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLK 279
Query: 290 ARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSI 349
ARL CSVPG + YFD L+ + + + + P + G+F T N G A+C + M I
Sbjct: 280 ARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDI 336
Query: 350 RAAFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSH 408
F G + ++ P+ W+ V E KVP PRPG CA Y T+ D+PD+ + F +SH
Sbjct: 337 EKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSH 396
Query: 409 PLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYN 468
PLM A+ P +P KT +Y L I+VD Y V+F+G++ G+VLKV+
Sbjct: 397 PLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA-KT 455
Query: 469 QEMESMEEVILEELQIF 485
+ V+LEE++ +
Sbjct: 456 SPFSLNDSVLLEEIEAY 472
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 259 bits (661), Expect = 9e-69
Identities = 190/619 (30%), Positives = 292/619 (47%), Gaps = 51/619 (8%)
Query: 61 MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVR 120
+L+D L+VG RD +++LSL + + I W + C KGK EC N+V+
Sbjct: 68 LLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQ 127
Query: 121 VLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFIS 180
+L N +HLLTCGT AFDP C I V + R E GRG+CPF+P+ +
Sbjct: 128 ILAIANASHLLTCGTFAFDPKCGVIDVSR-------FQQVERLESGRGKCPFEPAQRSAA 180
Query: 181 TLIGSELFAGLYSDYWSRDAAIFRSMGRLAH-IRTEHDDERLLKEPKFVGSYMIPDNE-- 237
+ G L+A +Y + I R++GR IRT+ L P FV + + E
Sbjct: 181 VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTD-TLPSWLNAPAFVAAVALSPAEWG 239
Query: 238 DRD-DNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSV 296
D D D+++YFFFTE + ++ RV R+C D+GG++ L +W+TFLKA L+C
Sbjct: 240 DEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPG 299
Query: 297 PGMNGIDTYFDELEDVFLL-PTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNG 355
P + L+DV +L P P+ +G+F++ A+C + IR NG
Sbjct: 300 PEHGRASSV---LQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNG 356
Query: 356 PYAH-KEGPEYHWSVYEGKVPYPRPGSC-ASKVNGGRYGTTKDYPDDAIRFARSHPLMYQ 413
P+ K V + VP PRPG C + + +G++ PD + F R HPLM +
Sbjct: 357 PFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDR 416
Query: 414 AIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEME 472
+ PA P+LV TD Y ++ RV + G +YDVL++GT++G + + + I
Sbjct: 417 PVFPADGHPLLVTTDTAY--LRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRI------ 468
Query: 473 SMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLA 532
+ +LE+L +F +P P+ +M++ L +GS + V QV +C S C++C LA
Sbjct: 469 GAQLSVLEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQS-CSECILA 525
Query: 533 RDPYCAWDGISCSRYYPTGTHA-KRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAY 591
+DP CAW R HA + R QD+ + + C + G+ E +A
Sbjct: 526 QDPVCAWS----FRLDECVAHAGEHRGLVQDIESADVSSLC--PKEPGERPVVFEVPVAT 579
Query: 592 GIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGT 651
+L C+P S A +W G + D V + G + G
Sbjct: 580 AAH---VVLPCSPSSAWASCVWHQPSG--VTALTPRRDGLEVVVTPGAM---------GA 625
Query: 652 YFCQTVEHSFVHTVRKITL 670
Y C+ E H V +L
Sbjct: 626 YACECQEGGAAHVVAAYSL 644
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 258 bits (660), Expect = 1e-68
Identities = 171/578 (29%), Positives = 271/578 (46%), Gaps = 66/578 (11%)
Query: 20 WTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVY 79
W G D L L + L LNRT L V RD V+
Sbjct: 46 WFRGLEDDAVAAELGLDFQRFLTLNRT-----------------------LLVAARDHVF 82
Query: 80 SLSLERISDGY-----KEIHWPSTALKMEECIMKGKDAGECANYVRVLHHYNRTHLLTCG 134
S L+ +G K + W S +E C ++GK EC NY+RVL ++ LL CG
Sbjct: 83 SFDLQAEEEGEGLVPNKYLTWRSQ--DVENCAVRGKLTDECYNYIRVLVPWDSQTLLACG 140
Query: 135 TGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRCPFDPSSSFISTLIGSELFAGLYS 193
T +F PVC + L+ E G+ RCPFD + S ++ L++ +
Sbjct: 141 TNSFSPVCRSYGIT--------SLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAA 192
Query: 194 DYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKAL 253
D+ + DA ++RS+G +R+ D + L+EP FV + D+ VYFFF E ++
Sbjct: 193 DFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDH-------VYFFFREVSV 245
Query: 254 EAENNAHAIYTRVGRLCVNDVGGQ-RILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDV 312
E ++RV R+C D+GG R L W++FLK RL CSVPG + YFD L+
Sbjct: 246 EDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQ-A 302
Query: 313 FLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWS-VYE 371
P H +FG+F T +N G A+C +++ I F G + + + W+ V E
Sbjct: 303 LTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSE 362
Query: 372 GKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKY 431
+VP PRPGSCA + +++D PDD + F ++HPL+ A+ P +P+L T +
Sbjct: 363 DRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLT-SRA 421
Query: 432 NLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIF------ 485
L Q+AVD + V+F+G+++G VLKV+T + E ++LEE+ +
Sbjct: 422 LLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRS-GGPEPILLEEIDAYSPARCS 480
Query: 486 -----KDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAW- 539
+ II +E+ ++ +L++ + + + C +G+ C ++DPYC W
Sbjct: 481 GKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGWH 540
Query: 540 DGISCSRYYPT-GTHAKRRFRRQDVRHGNAAQQCFGQQ 576
C + GT + ++ + HG+ G Q
Sbjct: 541 SSRGCVDIRGSGGTDVDQAGNQESMEHGDCQDGATGSQ 578
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 256 bits (653), Expect = 7e-68
Identities = 165/517 (31%), Positives = 256/517 (49%), Gaps = 38/517 (7%)
Query: 57 DLHTMLLDEYQERLFVGGRDLVYSLSLERISDG----YKEIHWPSTALKMEECIMKGKDA 112
DL+ + LF+G RD +Y + LE + +++ W S + C MKGK
Sbjct: 64 DLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQE 123
Query: 113 GECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPF 172
GEC N+V+VL + + L CG+ AF+PVCA + D L + S G RCP+
Sbjct: 124 GECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSI-----DTLQPVGDNIS--GMARCPY 176
Query: 173 DPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYM 232
DP + ++ LF +D+ + DA I+RS+G +RT D + KEP FV +
Sbjct: 177 DPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV- 235
Query: 233 IPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQ-RILVNKWSTFLKAR 291
+ VYFFF E A+E + +RV R+C NDVGG R+L +W++FLKAR
Sbjct: 236 ------EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKAR 289
Query: 292 LVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRA 351
L CSVPG + YF+ L+ V + + + PV+ +F+T SN G A+C + ++ + A
Sbjct: 290 LNCSVPGDSHF--YFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAA 346
Query: 352 AFNGPYAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPL 410
F G + ++ PE W+ V E +VP PRPG CA+ G +Y + PDD + F ++HPL
Sbjct: 347 VFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAP--GMQYNASSALPDDILNFVKTHPL 404
Query: 411 MYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQE 470
M +A+ P +++T ++ L ++AVD G V+F+G++ G VLK + N
Sbjct: 405 MDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNAS 464
Query: 471 MESME--EVILEELQIFKDP-----------VPIISMEISSKRQQLYIGSASAVAQVRFH 517
V LEE + ++ ++S+E+ + L V +V
Sbjct: 465 TSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVA 524
Query: 518 HCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHA 554
C Y +C ++DPYC W + GT A
Sbjct: 525 RCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRA 561
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 252 bits (643), Expect = 1e-66
Identities = 190/662 (28%), Positives = 300/662 (45%), Gaps = 63/662 (9%)
Query: 16 LLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGR 75
LL T G PR+R + S FH G D T+LL L+VG R
Sbjct: 25 LLPTTTAGGGGQGPMPRVRYYAGD--ERRALSFFHQK-GLQDFDTLLLSGDGNTLYVGAR 81
Query: 76 DLVYSLSLER--ISDGYKEIHWPSTALKMEECIMKGK-DAGECANYVRVLHHYNRTHLLT 132
+ + +L ++ + I WP++ K EC K K + +C N++RVL YN THL T
Sbjct: 82 EAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYT 141
Query: 133 CGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLY 192
CGT AF P C FI + + L + + G+G+ PFDP+ + L+ L++G
Sbjct: 142 CGTFAFSPACTFIELQ---DSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTM 198
Query: 193 SDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKA 252
+++ + + R++G ++T++ L + FV + IP + VYFFF E A
Sbjct: 199 NNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPSTQ-----VVYFFFEETA 251
Query: 253 LEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDV 312
E + +RV R+C NDVGG+++L KW+TFLKA+L+C+ PG F+ +
Sbjct: 252 SEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHA 307
Query: 313 FLLPTRDHKNPVIFGLFNTTSNI--FRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVY 370
LLP P I+ +F + + R A+C + + I F G Y W+ Y
Sbjct: 308 VLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTY 367
Query: 371 EGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGK 430
G PRPGSC+ + D A+ F + H LM + + P+LVK+ +
Sbjct: 368 RGPETNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQVVGT---PLLVKSGVE 414
Query: 431 YNLKQIAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPV 489
Y ++AV+ + DG + V+++GT G + K + + ++EE+Q+F DP
Sbjct: 415 YT--RLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAH-----LVEEIQLFPDPE 467
Query: 490 PIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGIS---CSR 546
P+ +++++ + +++G + V +V +C +Y S C DC LARDP+CAWD S C
Sbjct: 468 PVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYES-CVDCVLARDPHCAWDPESRTCCLL 526
Query: 547 YYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHL---AYGIENNSTLLECT 603
P K QD+ GN C ++ + + N+ L C
Sbjct: 527 SAPNLNSWK-----QDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCP 581
Query: 604 PRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVH 663
S A W G E T + G L L + G Y C E+ F +
Sbjct: 582 HLSALASYYW--SHGPAAVPEASST------VYNGSLLLIVQDGVGGLYQCWATENGFSY 633
Query: 664 TV 665
V
Sbjct: 634 PV 635
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 251 bits (642), Expect = 1e-66
Identities = 161/492 (32%), Positives = 249/492 (50%), Gaps = 47/492 (9%)
Query: 56 LDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGEC 115
+D + D Q+ L VG R+ ++ L LE +S + + W + C KGK EC
Sbjct: 56 VDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKEEC 114
Query: 116 ANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSE-RGRGRCPFDP 174
NY+RVL L TCGT AF PVC L +L + G RCP+ P
Sbjct: 115 QNYIRVLL-VGGDRLFTCGTNAFTPVCT--------NRSLSNLTEIHDQISGMARCPYSP 165
Query: 175 SSSFISTLI-GSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMI 233
+ + L G EL+A D+ RD AI+RS+G L +RT + + L EP FV SY I
Sbjct: 166 QHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDI 225
Query: 234 PDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLV 293
N YFFF E A+E + +++R R+C ND+GG+ +L + W+TF+KARL
Sbjct: 226 -------GNFTYFFFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLN 277
Query: 294 CSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAF 353
CS PG + Y++EL+ F LP D +I+G+F T N A+CV+++S+I AF
Sbjct: 278 CSRPG--EVPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAF 331
Query: 354 NGPYAHKEGPEYHWSVYEGKVPYPRPG---SCASKVNGGRYGTTKDYPDDAIRFARSHPL 410
+GP+ ++E W +PYP P C + G T+ DA +F L
Sbjct: 332 SGPFKYQENSRSAW------LPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFI----L 381
Query: 411 MYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQE 470
M++ ++P P ++ + +++ +AVD V+ + ++++ TD G + KV NQ
Sbjct: 382 MHEVVQPVTTVPSFMEDNSRFS--HVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQT 439
Query: 471 MESMEEVILEELQIFKD--PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACAD 528
S +LEE+++F + PI S++I + L++G V ++ C Y + +
Sbjct: 440 SSS---CLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTR-ST 495
Query: 529 CCLARDPYCAWD 540
C A+DPYC WD
Sbjct: 496 CIGAQDPYCGWD 507
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 251 bits (640), Expect = 2e-66
Identities = 165/491 (33%), Positives = 251/491 (51%), Gaps = 38/491 (7%)
Query: 54 GFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAG 113
G D + LD +L VG R+ ++ LSL +S + W S+ C KGK
Sbjct: 122 GARDFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEWASSEDTRRSCQSKGKTEE 180
Query: 114 ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFD 173
EC NYVRVL R + CGT AF P+C +VG +L + + G RCP+D
Sbjct: 181 ECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVG-NLSRTIEKIN------GVARCPYD 232
Query: 174 PSSSFISTLIGS-ELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYM 232
P + + + EL+A D+ RD AI+RS+G +RT + + L EP FV +Y
Sbjct: 233 PRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYD 292
Query: 233 IPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARL 292
I YFF E A+E + +Y+RV R+C NDVGG+ +L + W+TF+KARL
Sbjct: 293 I-------GLFAYFFLRENAVE-HDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARL 344
Query: 293 VCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAA 352
CS PG + Y++EL+ F LP +D +I+G+F T N A+C +++S+I A
Sbjct: 345 NCSRPG--EVPFYYNELQSAFHLPEQD----LIYGVFTTNVNSIAASAVCAFNLSAISQA 398
Query: 353 FNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMY 412
FNGP+ ++E P W +P + G+ G ++ + +++ A+ LM
Sbjct: 399 FNGPFRYQENPRAAWLPIANPIPNFQCGTLPET------GPNENLTERSLQDAQRLFLMS 452
Query: 413 QAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEME 472
+A++P +P + T + VD V+A+D Y VL+IGT++G +LK ++ ++
Sbjct: 453 EAVQPVTPEPCV--TQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASR--- 507
Query: 473 SMEEVILEELQIFKD--PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCC 530
S+ LEEL + P+ S+ I + L++G V +V C Y S A C
Sbjct: 508 SLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGA-CL 566
Query: 531 LARDPYCAWDG 541
ARDPYC WDG
Sbjct: 567 GARDPYCGWDG 577
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 196 bits (499), Expect = 5e-50
Identities = 179/657 (27%), Positives = 289/657 (43%), Gaps = 81/657 (12%)
Query: 16 LLELWTGGHTAD---TTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEY-QERLF 71
LL LW +A + PR+ K + +R FG + HT+L E ++
Sbjct: 34 LLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVD-----FGQTEPHTVLFHEPGSSSVW 88
Query: 72 VGGRDLVYSLSL-ERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVRVLHHYNRTHL 130
VGGR VY E + + ++ ST C+ D +C NY+ +L + L
Sbjct: 89 VGGRGKVYLFDFPEGKNASVRTVNIGSTK---GSCL----DKRDCENYITLLERRSEG-L 140
Query: 131 LTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAG 190
L CGT A P C + G + PL + RG PF P + + G E+++
Sbjct: 141 LACGTNARHPSCWNLVNGTVV--PLGEM--------RGYAPFSPDENSLVLFEGDEVYST 190
Query: 191 LYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTE 250
+ ++ FR + + + T + +++ P+F+ + ++ ++ DD K+Y+FF E
Sbjct: 191 IRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKATIVHQDQAYDD-KIYYFFRE 246
Query: 251 KALEAENNAHAIYTRVGRLCVNDVGGQRIL-VNKWSTFLKARLVCSVPGMNGIDTYFDEL 309
+ A +RV +LC D GG+ L V+KW+TFLKA LVCS N F+ L
Sbjct: 247 DNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN---KNFNRL 303
Query: 310 EDVFLLP--TRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW 367
+DVFLLP + ++ ++G+F SN + A+CVY + I F + +G
Sbjct: 304 QDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFRT--SSLKG----- 353
Query: 368 SVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAH--KKPILV 425
Y +P PRPG C + P + + A HP + Q ++P K P+
Sbjct: 354 --YHSSLPNPRPGKCLPD--------QQPIPTETFQVADRHPEVAQRVEPMGPLKTPLF- 402
Query: 426 KTDGKYNLKQIAVDRVEAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQI 484
KY+ +++AV R++A G+ + VL++ TD G + KV+ QE ++ E+Q
Sbjct: 403 --HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIM--EIQP 458
Query: 485 FKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISC 544
F+ I +M + ++R++LY+ S V+QV C++YG C C ++RDPYC WD C
Sbjct: 459 FRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRC 518
Query: 545 SRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTP 604
Y + R Q + ++C DK N+ L C
Sbjct: 519 ISIY-----SSERSVLQSINPAEPHKEC-----PNPKPDKAPLQKVSLAPNSRYYLSCPM 568
Query: 605 RSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSF 661
S A W ++ E E + L L G YFC+ E S+
Sbjct: 569 ESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEGSY 620
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 193 bits (490), Expect = 6e-49
Identities = 177/659 (26%), Positives = 284/659 (43%), Gaps = 99/659 (15%)
Query: 16 LLELWTGGHTAD---TTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEY-QERLF 71
LL LW +A + PR+ K + +R FG + HT+L E ++
Sbjct: 34 LLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVD-----FGQTEPHTVLFHEPGSSSVW 88
Query: 72 VGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAG---ECANYVRVLHHYNRT 128
VGGR VY +GK+A +C NY+ +L +
Sbjct: 89 VGGRGKVYLFDFP-----------------------EGKNASVRTDCENYITLLERRSEG 125
Query: 129 HLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELF 188
LL CGT A P C + G + PL + RG PF P + + G E++
Sbjct: 126 -LLACGTNARHPSCWNLVNGTVV--PLGEM--------RGYAPFSPDENSLVLFEGDEVY 174
Query: 189 AGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFF 248
+ + ++ FR + + + T + +++ P+F+ + ++ ++ DD K+Y+FF
Sbjct: 175 STIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKATIVHQDQAYDD-KIYYFF 230
Query: 249 TEKALEAENNAHAIYTRVGRLCVNDVGGQRIL-VNKWSTFLKARLVCSVPGMNGIDTYFD 307
E + A +RV +LC D GG+ L V+KW+TFLKA LVCS N F+
Sbjct: 231 REDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN---KNFN 287
Query: 308 ELEDVFLLP--TRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEY 365
L+DVFLLP + ++ ++G+F SN + A+CVY + I F + +G
Sbjct: 288 RLQDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFRT--SSLKG--- 339
Query: 366 HWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAH--KKPI 423
Y +P PRPG C + P + + A HP + Q ++P K P+
Sbjct: 340 ----YHSSLPNPRPGKCLPD--------QQPIPTETFQVADRHPEVAQRVEPMGPLKTPL 387
Query: 424 LVKTDGKYNLKQIAVDRVEAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEEL 482
KY+ +++AV R++A G+ + VL++ TD G + KV+ QE ++ E+
Sbjct: 388 F---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIM--EI 442
Query: 483 QIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGI 542
Q F+ I +M + ++R++LY+ S V+QV C++YG C C ++RDPYC WD
Sbjct: 443 QPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQG 502
Query: 543 SCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLEC 602
C Y + R Q + ++C DK N+ L C
Sbjct: 503 RCISIY-----SSERSVLQSINPAEPHKEC-----PNPKPDKAPLQKVSLAPNSRYYLSC 552
Query: 603 TPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSF 661
S A W ++ E E + L L G YFC+ E S+
Sbjct: 553 PMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEGSY 606
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 178 bits (451), Expect = 2e-44
Identities = 138/501 (27%), Positives = 227/501 (45%), Gaps = 53/501 (10%)
Query: 167 RGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPK 226
RG PF P + + G E+++ + ++ FR + + + T + +++ P+
Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQ 58
Query: 227 FVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRIL-VNKWS 285
F+ + ++ ++ DD K+Y+FF E + A +RV +LC D GG+ L V+KW+
Sbjct: 59 FIKATIVHQDQAYDD-KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWN 117
Query: 286 TFLKARLVCSVPGMNGIDTYFDELEDVFLLP--TRDHKNPVIFGLFNTTSNIFRGHAICV 343
TFLKA LVCS N F+ L+DVFLLP + ++ ++G+F SN + A+CV
Sbjct: 118 TFLKAMLVCSDAATN---KNFNRLQDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCV 171
Query: 344 YHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIR 403
Y + I F + +G Y +P PRPG C + P + +
Sbjct: 172 YSLGDIDKVFRT--SSLKG-------YHSSLPNPRPGKCLPD--------QQPIPTETFQ 214
Query: 404 FARSHPLMYQAIKPAH--KKPILVKTDGKYNLKQIAVDRVEAEDGQ-YDVLFIGTDNGIV 460
A HP + Q ++P K P+ KY+ +++AV R++A G+ + VL++ TD G +
Sbjct: 215 VADRHPEVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTI 271
Query: 461 LKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCD 520
KV+ QE ++ E+Q F+ I +M + ++R++LY+ S V+QV C+
Sbjct: 272 HKVVEPGEQEHSFAFNIM--EIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCE 329
Query: 521 MYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGD 580
+YG C C ++RDPYC WD C Y + R Q + ++C
Sbjct: 330 VYGGGCHGCLMSRDPYCGWDQGRCISIY-----SSERSVLQSINPAEPHKEC-----PNP 379
Query: 581 ALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLL 640
DK N+ L C S A W ++ E E + L
Sbjct: 380 KPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LF 434
Query: 641 FLRLHKSDAGTYFCQTVEHSF 661
L G YFC+ E S+
Sbjct: 435 IENLTAQQYGHYFCEAQEGSY 455
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,673,655
Number of Sequences: 37866
Number of extensions: 1514822
Number of successful extensions: 3945
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 3644
Number of HSP's gapped (non-prelim): 104
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.