Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 6912612
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1
[Homo sapiens]
(853 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H... 1785 0.0
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ... 1751 0.0
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ... 1667 0.0
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ... 1353 0.0
gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens] 793 0.0
gi|32261332 seizure related 6 homolog (mouse)-like precursor [Ho... 792 0.0
gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens] 778 0.0
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 232 1e-60
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 226 9e-59
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 224 3e-58
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 224 3e-58
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 208 2e-53
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 102 1e-21
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 102 1e-21
gi|148886654 polydom [Homo sapiens] 98 4e-20
gi|168693643 decay accelerating factor for complement isoform 2 ... 97 6e-20
gi|10835143 decay accelerating factor for complement isoform 1 p... 97 6e-20
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 92 3e-18
gi|157419154 selectin P precursor [Homo sapiens] 89 1e-17
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 82 2e-15
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 81 4e-15
gi|6912724 tolloid-like 2 [Homo sapiens] 80 6e-15
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
>gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo
sapiens]
Length = 853
Score = 1785 bits (4624), Expect = 0.0
Identities = 853/853 (100%), Positives = 853/853 (100%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 61 RRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLG 120
RRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLG
Sbjct: 61 RRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLG 120
Query: 121 SPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSM 180
SPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSM
Sbjct: 121 SPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSM 180
Query: 181 LGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGG 240
LGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGG
Sbjct: 181 LGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGG 240
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAV 300
TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAV
Sbjct: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAV 300
Query: 301 GPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGL 360
GPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGL
Sbjct: 301 GPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGL 360
Query: 361 ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFS 420
ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFS
Sbjct: 361 ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFS 420
Query: 421 CLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPG 480
CLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPG
Sbjct: 421 CLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPG 480
Query: 481 QDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP 540
QDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP
Sbjct: 481 QDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP 540
Query: 541 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY 600
DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY
Sbjct: 541 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY 600
Query: 601 QCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQ 660
QCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQ
Sbjct: 601 QCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQ 660
Query: 661 YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ 720
YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ
Sbjct: 661 YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ 720
Query: 721 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPS 780
AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPS
Sbjct: 721 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPS 780
Query: 781 RQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPL 840
RQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPL
Sbjct: 781 RQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPL 840
Query: 841 YEAGDTREYEVSI 853
YEAGDTREYEVSI
Sbjct: 841 YEAGDTREYEVSI 853
>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
[Homo sapiens]
Length = 840
Score = 1751 bits (4536), Expect = 0.0
Identities = 840/853 (98%), Positives = 840/853 (98%), Gaps = 13/853 (1%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 61 RRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLG 120
RRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLG
Sbjct: 61 RRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLG 120
Query: 121 SPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSM 180
SPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSM
Sbjct: 121 SPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSM 180
Query: 181 LGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGG 240
LGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGG
Sbjct: 181 LGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGG 240
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAV 300
TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAV
Sbjct: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAV 300
Query: 301 GPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGL 360
GPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGL
Sbjct: 301 GPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGL 360
Query: 361 ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFS 420
ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFS
Sbjct: 361 ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFS 420
Query: 421 CLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPG 480
CLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPG
Sbjct: 421 CLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPG 480
Query: 481 QDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP 540
QDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP
Sbjct: 481 QDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP 540
Query: 541 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY 600
DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY
Sbjct: 541 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY 600
Query: 601 QCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQ 660
QCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQ
Sbjct: 601 QCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQ 660
Query: 661 YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ 720
YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ
Sbjct: 661 YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ 720
Query: 721 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPS 780
AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK VTQTTDPS
Sbjct: 721 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK-------------VTQTTDPS 767
Query: 781 RQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPL 840
RQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPL
Sbjct: 768 RQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPL 827
Query: 841 YEAGDTREYEVSI 853
YEAGDTREYEVSI
Sbjct: 828 YEAGDTREYEVSI 840
>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
[Homo sapiens]
Length = 910
Score = 1667 bits (4317), Expect = 0.0
Identities = 820/923 (88%), Positives = 824/923 (89%), Gaps = 83/923 (8%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPE---------------------- 38
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPE
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 39 ---------PGSET-PTVASEALAELLHGALLRRGPEMGY-------------------- 68
PGS+ PT+A+ + L L R E G
Sbjct: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
Query: 69 ------------------LPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 110
PGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG
Sbjct: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 180
Query: 111 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 170
EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL
Sbjct: 181 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
Query: 171 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 230
APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD
Sbjct: 241 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 300
Query: 231 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 290
VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR
Sbjct: 301 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 360
Query: 291 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 350
IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS
Sbjct: 361 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 420
Query: 351 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 410
DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE
Sbjct: 421 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 480
Query: 411 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 470
YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS
Sbjct: 481 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 540
Query: 471 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 530
PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ
Sbjct: 541 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 600
Query: 531 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 590
PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG
Sbjct: 601 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 660
Query: 591 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 650
DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD
Sbjct: 661 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 720
Query: 651 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 710
AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG
Sbjct: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
Query: 711 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRK 770
YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK
Sbjct: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK----------- 829
Query: 771 LEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI 830
VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI
Sbjct: 830 --VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI 887
Query: 831 TVESDFSNPLYEAGDTREYEVSI 853
TVESDFSNPLYEAGDTREYEVSI
Sbjct: 888 TVESDFSNPLYEAGDTREYEVSI 910
>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
[Homo sapiens]
Length = 809
Score = 1353 bits (3502), Expect = 0.0
Identities = 639/639 (100%), Positives = 639/639 (100%)
Query: 215 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 274
AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS
Sbjct: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
Query: 275 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 334
CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL
Sbjct: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
Query: 335 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 394
MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC
Sbjct: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
Query: 395 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK
Sbjct: 351 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 410
Query: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 514
AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD
Sbjct: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 470
Query: 515 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 574
GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC
Sbjct: 471 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 530
Query: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 634
PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT
Sbjct: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 590
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC
Sbjct: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
Query: 695 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 754
ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ
Sbjct: 651 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 710
Query: 755 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 814
PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ
Sbjct: 711 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 770
Query: 815 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 853
GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
Sbjct: 771 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
Score = 174 bits (441), Expect = 3e-43
Identities = 222/859 (25%), Positives = 319/859 (37%), Gaps = 255/859 (29%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPE---------------------- 38
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPE
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 39 ---------PGSET-PTVASEALAELLHGALLRRGPEMGY-------------------- 68
PGS+ PT+A+ + L L R E G
Sbjct: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
Query: 69 ------------------LPGPPLGPEGGEEETTTT------IITTTT------------ 92
PGPPLGPEGGEEETTTT + TT T
Sbjct: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
Query: 93 ------VTTTVTSP-------------------VLCNNNIS---EGE---------GYVE 115
V+ T P ++C N GE G +
Sbjct: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
Query: 116 SPDLGSPVSRTLG-----LLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 170
+ LG VS G L C + I G + + + ++L ++ + L++ GGSP L
Sbjct: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP-L 299
Query: 171 AP-------------RLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
+P L++++ L + +P N LLL + ++A+
Sbjct: 300 SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLL-------------SLRFEAFE 346
Query: 218 LSCGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQ---GEETLICLNGTRPSWNGET 272
F P AHG+V+ TD PG ATF C GY L+ + C++ T P WN
Sbjct: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
Query: 273 PSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDND 332
P+C A CGG + + G ++SP+ + P C W + E +R+ L E +++ E D
Sbjct: 407 PACKAMCGGEL-SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GD 464
Query: 333 RLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET-PANPLL---LSLRF-E 387
L + G P + V+ P R L+S L ++ + P NP L L F E
Sbjct: 465 MLTLFDGDGPSARVLAQL-RGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
Query: 388 AFEEDRC-FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHW 446
D C P G T + + G + T+ C PGY L + + C + W
Sbjct: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL---GSDILTC--QWDLSW 578
Query: 447 NDTEPACKAM--CG--GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 502
+ PAC+ + C GE++ +P C+ G
Sbjct: 579 SAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG---------------Y 623
Query: 503 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 562
++ MLT + D + + ++ P L+++ P L G
Sbjct: 624 SLEGAAMLTCYSRDTGTPKWSDRV-------------PKCALKYE-------PCLNPG-- 661
Query: 563 LHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--QWDL 620
VP N G++T G L + C G+EL+G +TC
Sbjct: 662 -----VPEN-----------GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
Query: 621 SWSAAPPACQ------------KIMTCADPGEIANGHRTASDAGFPV--------GSHVQ 660
W++ PP C+ ++ DP G A P+ G ++
Sbjct: 706 QWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIY 765
Query: 661 YRCLPGYSLEGAAMLTCYS 679
Y L G SL G + YS
Sbjct: 766 YTKLQGKSLFGFSGSHSYS 784
>gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens]
Length = 993
Score = 793 bits (2049), Expect = 0.0
Identities = 392/783 (50%), Positives = 531/783 (67%), Gaps = 15/783 (1%)
Query: 78 GGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESP-DLGSPVSRTLGLLDCTYSI 136
G +EETTTT TT TTV +P C+ N S EG ++SP DL SP +GL DC + I
Sbjct: 219 GDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTD--VGL-DCFFYI 275
Query: 137 HVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLL 196
VYPGYG+EI+VQ ++L +E E + + G G P P LAN S L GQV+RSPT++ L
Sbjct: 276 SVYPGYGVEIKVQNISL-REGETVTVEGLGGPDPLP--LANQSFLLRGQVIRSPTHQAAL 332
Query: 197 HFQSPRVPRGGG-FRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGE 255
FQS P G G F HYQAYLLSC FP RPA+GDV+VT LHPGG+A FHC +GYQL+G
Sbjct: 333 RFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGA 392
Query: 256 ETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEG 315
L CLN T+P W+ + P C+A+CGG I NAT GRIVSP G NLTC W++EA EG
Sbjct: 393 RHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEG 452
Query: 316 RRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSE 374
+RLHLHFE+VSL ED+DRL++R+G + +P +YDS +++ +P GL+S + +VEL ++
Sbjct: 453 QRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTD 512
Query: 375 TPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPN 434
+ ++LR+EAF++ C+ PF+ +GN +++ P Y G FSC PGY LE
Sbjct: 513 SSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSI-- 570
Query: 435 AIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKR 494
IECVDP +P WN+TEPAC+A+C GE+++ AGVVLSP+WP+ Y GQDC+WGVHV+E+KR
Sbjct: 571 IIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKR 630
Query: 495 ILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPN 554
I+L + +L + GD+LT +DGD +ARVL Q GP+ +L +S D+T+QFQ+ PG
Sbjct: 631 IMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSV 690
Query: 555 PGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDIL 614
G QGFV+HF EVPRNDTCPELP GW++ S +L+ GTV+TYQC PGY+++GS +L
Sbjct: 691 LGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVL 750
Query: 615 TCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM 674
CQWDL+WS P+CQ++ +C DPG++ + R S FPVG+ VQY C G+ L G+++
Sbjct: 751 MCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSI 810
Query: 675 LTCYSRDTGTPKWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF 733
LTC+ R G+PKWSDR PKC L + +PC PENG ++ K + AG ++ F C G+
Sbjct: 811 LTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGY 870
Query: 734 ELIGEVTITCVPGHPSQWTSQPPLCKVA-YEELLDNRKLEVTQTTDPSRQLEGGNLALAI 792
L G+ +I CVPGHPS W+ PP+C+ A + ++R L+V + S L+ ++A AI
Sbjct: 871 VLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAI 930
Query: 793 LLPLGLVIVLGSGVYIYYTKLQGKSLFGF--SGSHSYSPITVESDFSNPLYEAGDTREYE 850
LPL +++L GVY Y+++LQGKS Y+ IT+ES F NP YE G+TREYE
Sbjct: 931 FLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETGETREYE 990
Query: 851 VSI 853
VSI
Sbjct: 991 VSI 993
>gi|32261332 seizure related 6 homolog (mouse)-like precursor [Homo
sapiens]
Length = 1024
Score = 792 bits (2045), Expect = 0.0
Identities = 399/822 (48%), Positives = 542/822 (65%), Gaps = 21/822 (2%)
Query: 37 PEPGSETPTVASEALAELLHG-ALLRRGPEMGYLPGPPLGPEGGEEETTTTIITTTTVTT 95
PEPG P +A EA E AL+ +G L G E +E TT+TIITTT +TT
Sbjct: 219 PEPGEPGPDMAQEAPQEDTSPMALMDKGENE--LTGS--ASEESQETTTSTIITTTVITT 274
Query: 96 TVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQ 155
+P LC+ + S EGY++S D P+ L+CTY++ VY GYG+E+QV+++NLS
Sbjct: 275 E-QAPALCSVSFSNPEGYIDSSDY--PLLPLNNFLECTYNVTVYTGYGVELQVKSVNLS- 330
Query: 156 EEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 215
+ ELL + G P L +LAN ++L EGQV+RSPTN + ++F++ + G F++HYQA
Sbjct: 331 DGELLSIRGVDGPTLT--VLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQA 388
Query: 216 YLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
++LSC FP RP GDV+V DLH GG A FHC GY+LQG + L C+N ++P W+ + P C
Sbjct: 389 FMLSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPIC 448
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
A CGG +HNAT+GR++SP + C W IEA EG++LHLHFER+ L D DR+
Sbjct: 449 SAPCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLL-HDKDRMT 507
Query: 336 VRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 394
V SG + S ++YDS + VP GL+S+ ++ +E S+ ++RFEAFE+ C
Sbjct: 508 VHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGHC 567
Query: 395 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
+ P++ +GN TT+DP Y G + F+C PG++LE P IEC++ +P+WNDTEP C+
Sbjct: 568 YEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQG--PAIIECINVRDPYWNDTEPLCR 625
Query: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 514
AMCGGELS AGVVLSP+WP+ Y G+DC+W +HV EEKRI L ++ LN+ D+LT++D
Sbjct: 626 AMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILTIYD 685
Query: 515 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 574
GD +L Q G ++L SS PDLT+QF + P G GQGF++++ EV RND+C
Sbjct: 686 GDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSC 745
Query: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 634
+LP + GW+T SH +L+RG +TYQC+PGY+++GSD LTCQWDLSWS+ PP C+KIM
Sbjct: 746 SDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIMY 805
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
C DPGE+ + R SD VG+ +QY C PG+ LEG+++LTCYSR+TGTP W+ R+P C
Sbjct: 806 CTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHC 865
Query: 695 ALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 753
+ C NPG+PENGYQ LYK Y GESL F CYEGFEL+GEVTI C+ G PS W
Sbjct: 866 VSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWNG 925
Query: 754 QPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKL 813
P+CKV + LEV + LEGGN+ALAI +P+ ++ +L G YIY T+
Sbjct: 926 PLPVCKVNQDSF--EHALEVAEAA-AETSLEGGNMALAIFIPVLIISLLLGGAYIYITRC 982
Query: 814 QGKS--LFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 853
+ S SH YS ITVE++F NP+YE G+TREYEVSI
Sbjct: 983 RYYSNLRLPLMYSHPYSQITVETEFDNPIYETGETREYEVSI 1024
>gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens]
Length = 994
Score = 778 bits (2008), Expect = 0.0
Identities = 384/774 (49%), Positives = 522/774 (67%), Gaps = 15/774 (1%)
Query: 78 GGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESP-DLGSPVSRTLGLLDCTYSI 136
G +EETTTT TT TTV +P C+ N S EG ++SP DL SP +GL DC + I
Sbjct: 219 GDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTD--VGL-DCFFYI 275
Query: 137 HVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLL 196
VYPGYG+EI+VQ ++L +E E + + G G P P LAN S L GQV+RSPT++ L
Sbjct: 276 SVYPGYGVEIKVQNISL-REGETVTVEGLGGPDPLP--LANQSFLLRGQVIRSPTHQAAL 332
Query: 197 HFQSPRVPRGGG-FRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGE 255
FQS P G G F HYQAYLLSC FP RPA+GDV+VT LHPGG+A FHC +GYQL+G
Sbjct: 333 RFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGA 392
Query: 256 ETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEG 315
L CLN T+P W+ + P C+A+CGG I NAT GRIVSP G NLTC W++EA EG
Sbjct: 393 RHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEG 452
Query: 316 RRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSE 374
+RLHLHFE+VSL ED+DRL++R+G + +P +YDS +++ +P GL+S + +VEL ++
Sbjct: 453 QRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTD 512
Query: 375 TPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPN 434
+ ++LR+EAF++ C+ PF+ +GN +++ P Y G FSC PGY LE
Sbjct: 513 SSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSI-- 570
Query: 435 AIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKR 494
IECVDP +P WN+TEPAC+A+C GE+++ AGVVLSP+WP+ Y GQDC+WGVHV+E+KR
Sbjct: 571 IIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKR 630
Query: 495 ILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPN 554
I+L + +L + GD+LT +DGD +ARVL Q GP+ +L +S D+T+QFQ+ PG
Sbjct: 631 IMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSV 690
Query: 555 PGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDIL 614
G QGFV+HF EVPRNDTCPELP GW++ S +L+ GTV+TYQC PGY+++GS +L
Sbjct: 691 LGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVL 750
Query: 615 TCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM 674
CQWDL+WS P+CQ++ +C DPG++ + R S FPVG+ VQY C G+ L G+++
Sbjct: 751 MCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSI 810
Query: 675 LTCYSRDTGTPKWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF 733
LTC+ R G+PKWSDR PKC L + +PC PENG ++ K + AG ++ F C G+
Sbjct: 811 LTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGY 870
Query: 734 ELIGEVTITCVPGHPSQWTSQPPLCKVA-YEELLDNRKLEVTQTTDPSRQLEGGNLALAI 792
L G+ +I CVPGHPS W+ PP+C+ A + ++R L+V + S L+ ++A AI
Sbjct: 871 VLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAI 930
Query: 793 LLPLGLVIVLGSGVYIYYTKLQGKSLFGF--SGSHSYSPITVESDFSNPLYEAG 844
LPL +++L GVY Y+++LQGKS Y+ IT+ES F NP YE G
Sbjct: 931 FLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETG 984
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 232 bits (591), Expect = 1e-60
Identities = 158/518 (30%), Positives = 253/518 (48%), Gaps = 21/518 (4%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N+++ +G + SP+ PV+ +C YSI PG GI+++ + LS+ + L V
Sbjct: 1098 CGNSVTGTQGTLLSPNF--PVNYNNNH-ECIYSIQTQPGKGIQLKARAFELSEGDVLKVY 1154
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLSCG 221
G + + ++S M+G L S ++ L L F + GF +H+ ++ L+ C
Sbjct: 1155 DGNNNSARLLGVFSHSEMMGV--TLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCE 1212
Query: 222 FPPRPAHGDVSVTDLH-PGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
P P G + H G + +F CD GY L+G E L+CL+G R +W+ P+C+A CG
Sbjct: 1213 DPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECG 1272
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
GT+ G+++SP NL C W IEA G + LHF +E +D L + G
Sbjct: 1273 GTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGP 1332
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
++ + +P + L S S+ ++ ++ + +++F C P +
Sbjct: 1333 VESGVLLKELSGPALP-KDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIP 1391
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVD-PTEPHWNDTEPACKAMCGG 459
N + + + G F C PGYAL+ I CV W + P C A CGG
Sbjct: 1392 Q-NGSRSGDSWEAGDSTVFQCDPGYALQGSA---EISCVKIENRFFWQPSPPTCIAPCGG 1447
Query: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518
+L+ P+GV+LSP++P+ Y PG++C W V V + I L I N+ G D L ++DG
Sbjct: 1448 DLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDS 1507
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578
+ ++ G Q R+ SS L L F++ N GFV+ + E PR ++C +
Sbjct: 1508 LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSN----AGFVIDYTENPR-ESCFDPG 1562
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC 616
+ G R S DL G+ +TY C GYE+ G+ L+C
Sbjct: 1563 SIKNGTRVGS--DLKLGSSVTYYCHGGYEVEGTSTLSC 1598
Score = 201 bits (510), Expect = 3e-51
Identities = 189/747 (25%), Positives = 301/747 (40%), Gaps = 79/747 (10%)
Query: 109 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 168
E G V SP +P L +C ++I G I + + + ++L + G P
Sbjct: 1278 EVSGQVLSPGYPAPYEHNL---NCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDG--P 1332
Query: 169 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQ-AYLLSCGFPPRPA 227
+ LL S + L S N ++L F + GF I + + SC P P
Sbjct: 1333 VESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQ 1392
Query: 228 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 286
+G S G + F CD GY LQG + C+ R W P+C+A CGG +
Sbjct: 1393 NGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGP 1452
Query: 287 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 346
+ G I+SP P C W + + + L F +L+ D L + G LSP+
Sbjct: 1453 S-GVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPL 1511
Query: 347 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTT 406
I +P R + S + SL++ S+ + + + + CF P N T
Sbjct: 1512 IGSFYGSQLPGR-IESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIK-NGTR 1569
Query: 407 TDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAG 466
+ + G+ T+ C GY +E + I D +P WN+ P C A CGG+ G
Sbjct: 1570 VGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDG-KPVWNNPRPVCTAPCGGQYVGSDG 1628
Query: 467 VVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQL 526
VVLSP++PQ+Y+ GQ C++ V V ++ + Q + D++ + DG +R+L+ L
Sbjct: 1629 VVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSL 1688
Query: 527 RGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELPPPEWG 583
G L L++ + ++F A P +GF ++ VPR C +P P +G
Sbjct: 1689 SGSHTGESLPLATSNQVLIKFSAKGLAP----ARGFHFVYQAVPRTSATQCSSVPEPRYG 1744
Query: 584 WRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMTCADPG 639
R S D G ++ ++C GY L GS + C W+ + P C ++ C G
Sbjct: 1745 KRLGS--DFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC--VVPCG--G 1798
Query: 640 EIANGHRTASDAGF----------------PVGSHVQYRCLPGYS---------LEGA-- 672
+ T GF P G+ +Q + + + +GA
Sbjct: 1799 NLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADN 1858
Query: 673 --------------AMLTCYSRDTGTPKWSDRVPKCA---LKYE-----PCLNPGVPENG 710
A+L S +SD A L+Y+ C P VP NG
Sbjct: 1859 TVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNG 1918
Query: 711 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRK 770
+T Y + + F C G+ L G I+C+PG +W PPLC ++ +
Sbjct: 1919 VKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEME 1976
Query: 771 LEVTQTTDPSRQLEGGNLALAILLPLG 797
+ P + + I LP+G
Sbjct: 1977 GVILSPGFPGNYPSNMDCSWKIALPVG 2003
Score = 199 bits (506), Expect = 9e-51
Identities = 190/743 (25%), Positives = 304/743 (40%), Gaps = 81/743 (10%)
Query: 74 LGPEGGEEETTTTIITTTTV---TTTVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLL 130
LG +G E T T ++ +V + + C +++ G + SP G P L
Sbjct: 722 LGTQGSE--TITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSP--GWP-GFYKDAL 776
Query: 131 DCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSP 190
C + I PGY I+I + L + G + AP L+ Q L S
Sbjct: 777 SCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYS-AP-LIGVYHGTQVPQFLIST 834
Query: 191 TNRLLLHFQSPRVPRGGGFRIHYQAYLLS---CGFPPRPAHGDVSVTDLHPGGTATFHCD 247
+N L L F + + GF++ Y+ L C P P +G D + G TF CD
Sbjct: 835 SNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCD 894
Query: 248 SGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCR 307
SGY L E L C + W+ PSC A CGG I ++ G I+SP NL C
Sbjct: 895 SGYTLSDGEPLECEPNFQ--WSRALPSCEALCGGFIQGSS-GTILSPGFPDFYPNNLNCT 951
Query: 308 WVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV--IYDSDMDDVPERGLISDAQ 365
W+IE + G+ + F L+ +D L++ GS P+ + S + GL +
Sbjct: 952 WIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFT 1011
Query: 366 SLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGY 425
+ V +S+ + ++ F ++ + C P + ++ ++ G TFSC PGY
Sbjct: 1012 A-QVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRK-GLQFGVGDTLTFSCFPGY 1069
Query: 426 ALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVW 485
LE I C+ W+ P C A CG ++ G +LSP++P +Y+ +C++
Sbjct: 1070 RLEGTA---RITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIY 1126
Query: 486 GVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTL 544
+ Q K I L+ + EGD+L ++DG+ SAR+L + L S+ L L
Sbjct: 1127 SIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWL 1186
Query: 545 QFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEP 604
F +GF LHF C + P++G++ G G+ +++ C+P
Sbjct: 1187 DFITDA----ENTSKGFELHFSSF-ELIKCEDPGTPKFGYKVHDEGH-FAGSSVSFSCDP 1240
Query: 605 GYELLGSDILTC------QWDLSWSAAPPACQKIMTCADPGEIANGHRTA---------- 648
GY L GS+ L C WD C + G++ + A
Sbjct: 1241 GYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIW 1300
Query: 649 ---SDAGFPVGSH-----------------------VQYRCLPGYSLEG------AAMLT 676
++AG +G H V + L G +L +++
Sbjct: 1301 TIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVL 1360
Query: 677 CYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELI 736
+S D T K + C +PG+P+NG ++ ++AG+S F C G+ L
Sbjct: 1361 QFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS--GDSWEAGDSTVFQCDPGYALQ 1418
Query: 737 GEVTITCVP-GHPSQWTSQPPLC 758
G I+CV + W PP C
Sbjct: 1419 GSAEISCVKIENRFFWQPSPPTC 1441
Score = 176 bits (446), Expect = 8e-44
Identities = 169/712 (23%), Positives = 281/712 (39%), Gaps = 76/712 (10%)
Query: 102 LCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVY-PGYGIEIQVQTLNLSQEEELL 160
+C+ ++ G + SP+ C + I P I++ + +L + + L
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNA---HCVWIITALNPSKVIKLAFEEFDLERGYDTL 460
Query: 161 VLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-S 219
+ GG G +L + ++ S +++ L FQ+ GF+ Y+ S
Sbjct: 461 TVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGS 520
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279
CG P PA+G + H G T F C ++L G++ + C + W+ + P C+ SC
Sbjct: 521 CGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQ--WSAKKPGCVFSC 578
Query: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339
+ + G ++SP G +L C W+I A R+HL F + ++ D L+++ G
Sbjct: 579 FFNFTSPS-GVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDG 637
Query: 340 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL 399
+ +PV+ + +P + S +E ++ ++ F F + C P +
Sbjct: 638 ATAEAPVLGTFSGNQLPS-SITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGV 696
Query: 400 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 459
D + G+ +F C G+ L G + WN C+A CGG
Sbjct: 697 PVNGKRFGD-SLQLGSSISFLCDEGF-LGTQGSETITCVLKEGSVVWNSAVLRCEAPCGG 754
Query: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518
L+ P+G +LSP WP Y C W + Q I + + D L + DG
Sbjct: 755 HLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTY 814
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP-RNDTCPEL 577
SA ++ G Q + L+S+ L L F + G F L ++ + ++D C +
Sbjct: 815 SAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIG----FQLRYETITLQSDHCLDP 870
Query: 578 PPPEWGWRTASHG-DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--- 633
P G R HG D G ++T+ C+ GY L + L C+ + WS A P+C+ +
Sbjct: 871 GIPVNGQR---HGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGF 927
Query: 634 ------TCADPG---------------EIANG-------HRTASDAGFPV------GSHV 659
T PG E ++G H ++G GS
Sbjct: 928 IQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFT 987
Query: 660 Q-YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYE------------PCLNPGV 706
Q R L G L Y T ++ + ++ YE PC P V
Sbjct: 988 QPLRQLTGSRLPAPISAGLYGNFTAQVRF---ISDFSMSYEGFNITFSEYDLEPCEEPEV 1044
Query: 707 PENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
P Y + G++L F C+ G+ L G ITC+ G W+S P C
Sbjct: 1045 P--AYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRC 1094
Score = 172 bits (436), Expect = 1e-42
Identities = 186/761 (24%), Positives = 281/761 (36%), Gaps = 129/761 (16%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C +G V SP+ P + T G + C Y + V Y + Q + + + + V
Sbjct: 1619 CGGQYVGSDGVVLSPNY--PQNYTSGQI-CLYFVTVPKDYVVFGQFAFFHTALNDVVEVH 1675
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPT-NRLLLHFQSPRVPRGGGFRIHYQAY----L 217
G RLL++ S G+ L T N++L+ F + + GF YQA
Sbjct: 1676 DGHSQHS---RLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSA 1732
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN--GTRPSWNGETPSC 275
C P P +G +D G F C+SGY LQG + CL G WN P+C
Sbjct: 1733 TQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
+ CGG + G I+SP +L C W I EG + + +++ D L
Sbjct: 1793 VVPCGGNLTERR-GTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLE 1851
Query: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395
V G ++ VP L S + LY+ S+ + L ++ C
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPAL-LNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCP 1910
Query: 396 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKA 455
P + V T + Y + +F C PGYAL+ I C+ T WN P C A
Sbjct: 1911 EPAVPSNGVKTGE-RYLVNDVVSFQCEPGYALQGHAH---ISCMPGTVRRWNYPPPLCIA 1966
Query: 456 MCGGELSEPAGVVLSPDWPQSYSPGQDCVW--------GVHVQEEKRILLQVEILNVREG 507
CGG + E GV+LSP +P +Y DC W G H+Q +
Sbjct: 1967 QCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ-------FLNFSTEPNH 2019
Query: 508 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLG--------- 558
D + + +G ++R++ + G + LLS+ + T+ F + PG
Sbjct: 2020 DYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYS 2079
Query: 559 -------QGFVLHFKEVPRNDTCP--------------------ELPPPEWGWRTASHGD 591
+GF L E+ R ++ P E P PE G
Sbjct: 2080 HQISSFLRGFDL--SELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGA 2137
Query: 592 LIR-GTVLTYQCEPGYELLGSDILTCQ--WDLSWSAAPPACQKIMTCADPGEIANGHRTA 648
G +T++C PGY+L G +LTCQ + +W P C+ + C G I + + T
Sbjct: 2138 GYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE--VPCG--GNITSSNGTV 2193
Query: 649 SDAGFPVGSHVQYRCL--------PGYSLEGAAMLTCYSRDTGTPKW---SDRVPKCALK 697
GFP C+ G L + + T S D T W P+ +
Sbjct: 2194 YSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFIT-IWDGPQQTAPRLGVF 2252
Query: 698 YEPCLNPGVPENGYQTLYKHH--------------------------------------Y 719
V + Q L K H +
Sbjct: 2253 TRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEF 2312
Query: 720 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 760
G+ +R+ C GF L+G +TC G Q+ PP+C+V
Sbjct: 2313 NIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353
Score = 168 bits (425), Expect = 2e-41
Identities = 168/715 (23%), Positives = 274/715 (38%), Gaps = 84/715 (11%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + E EG + SP G P + + DC++ I + G+G IQ + + + +
Sbjct: 1968 CGGTVEEMEGVILSP--GFPGNYPSNM-DCSWKIALPVGFGAHIQFLNFSTEPNHDYIEI 2024
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQ-------- 214
G P R++ S L S ++ ++F S GF++ YQ
Sbjct: 2025 RNG--PYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQI 2082
Query: 215 ----------------------------------AY-LLSCGFPPRPAHGDVSVTDLHPG 239
AY L C P A+G V + G
Sbjct: 2083 SSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVG 2142
Query: 240 GTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGA 299
+ TF C GYQL G L C +GT +W+ P C CGG I ++ G + SP
Sbjct: 2143 QSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSN-GTVYSPGFPSP 2201
Query: 300 VGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSP--VIYDSDMDDVPE 357
+ C W+I G + L+ + + D + + G +P ++ M
Sbjct: 2202 YSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSM----A 2257
Query: 358 RGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP-FLAHGNVTTTDPEYRPGAL 416
+ + + + + A + ++ F A+ +C P L + V T + E+ G +
Sbjct: 2258 KKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDI 2317
Query: 417 ATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE--LSEPAGVVLSPDWP 474
+ CLPG+ L + C T + P C+ C L++ GV+LS +P
Sbjct: 2318 VRYRCLPGFTLV---GNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYP 2374
Query: 475 QSYSPGQDCVWGVHVQEEKRILLQVE-ILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR 533
SY Q C W V V+ + I L VE L+ ++ D +FDG + +L L G
Sbjct: 2375 GSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAP 2434
Query: 534 RLL-SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDL 592
++ SS + L++ + G + + +PR P G+
Sbjct: 2435 LIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPR--------APLHGFILGQTSTQ 2486
Query: 593 IRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMTCADPGEIANGHRTA 648
G++ + C GY L+G + C Q WS A P CQ ++C P NG
Sbjct: 2487 PGGSI-HFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ-ALSCGLPEAPKNGMVFG 2544
Query: 649 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR--VPKCALKYEPCLNPGV 706
+ + VG+ Y C GY L+ A T DTG WS+R P+C P ++
Sbjct: 2545 KE--YTVGTKAMYSCSEGYHLQAGAEATAECLDTGL--WSNRNVPPQCVPVTCPDVSSIS 2600
Query: 707 PENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 760
E+G ++ +++ YQ L C G+ G+ I C P C++
Sbjct: 2601 VEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRI 2655
Score = 140 bits (354), Expect = 4e-33
Identities = 153/572 (26%), Positives = 237/572 (41%), Gaps = 68/572 (11%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + G VESP G P +CT++I + I++ Q+ L ++ ++L +
Sbjct: 26 CTFQLHGPNGTVESP--GFPYGYP-NYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSV 82
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SCG 221
G P L + + S L L S GF Y+ +CG
Sbjct: 83 FDG--PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCG 140
Query: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSCMA-- 277
P R +G + + G + C+ G+ L+G L C G+ S W+ PSC A
Sbjct: 141 NPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADD 200
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
+CGGT+ + G I SP N C W I A G + L F L++ D L V
Sbjct: 201 ACGGTLRGQS-GIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVT 259
Query: 338 ---------SGGSPLSPVI---------YDSDMDDVPERGLISDAQ-SLYVELLSETPAN 378
+G S +PVI + SD + +RG + Q +EL S
Sbjct: 260 GTEGSSLWFTGASLPAPVISSKNWLRLHFTSD-GNHRQRGFSAQYQVKKQIELKSR---G 315
Query: 379 PLLLSLRFEAFEEDRCFAPFLAHGNVTTTDP-----------EYRPGALATFSCLPGYAL 427
L+ + + + ++ G+ DP ++R G+ F+C GY L
Sbjct: 316 VKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDL 375
Query: 428 EPPGPPNAIECVDPTE--PHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDCV 484
+ I C+ ++ W+D P C+A MC L P+G++ SP++P Y CV
Sbjct: 376 Q---GSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCV 432
Query: 485 WGV-HVQEEKRILLQVEILNVREG-DMLTLFDG--DGPSARVLAQLRGPQPRRRLLSSGP 540
W + + K I L E ++ G D LT+ DG DG VL L G ++S+
Sbjct: 433 WIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNH 492
Query: 541 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTAS---HGDLIRGTV 597
+ L FQ G GF ++E+ + +C + P +G R S HGD
Sbjct: 493 QMWLLFQT----DGSGSSLGFKASYEEIEQG-SCGDPGIPAYGRREGSRFHHGD-----T 542
Query: 598 LTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
L ++C+P +EL+G +TCQ + WSA P C
Sbjct: 543 LKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Score = 139 bits (351), Expect = 9e-33
Identities = 192/848 (22%), Positives = 296/848 (34%), Gaps = 155/848 (18%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + G + SP S DCT++I G I + L + L +
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNA---DCTWTILAELGDTIALVFIDFQLEDGYDFLEV 258
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPT----NRLLLHFQSPRVPRGGGFRIHYQAYLL 218
G SS+ G L +P N L LHF S R GF YQ
Sbjct: 259 TG----------TEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQ 308
Query: 219 ---------------------------------SCGFPPRPAHGDVSVTDLHPGGTATFH 245
C P P G +D G + F
Sbjct: 309 IELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFT 368
Query: 246 CDSGYQLQGEETLICLNGTR--PSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPN 303
C+ GY LQG + + C+ + +W+ P C A G I SP N
Sbjct: 369 CNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNN 428
Query: 304 LTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLMVRSGGSP--LSPVIYDSDMDDVPERGL 360
C W+I A + + L FE L+ D L V GG V+Y VP+ +
Sbjct: 429 AHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDL-I 487
Query: 361 ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL-AHGNVTTTDPEYRPGALATF 419
+S +++ ++ + L +E E+ C P + A+G + G F
Sbjct: 488 VSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGR--REGSRFHHGDTLKF 545
Query: 420 SCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSP 479
C P + L AI C + W+ +P C C + P+GVVLSP++P+ Y
Sbjct: 546 ECQPAFELVGQ---KAITCQKNNQ--WSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGN 600
Query: 480 GQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSS 538
CVW + + E RI L ++V + D L + DG A VL G Q + SS
Sbjct: 601 HLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSS 660
Query: 539 GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR-GTV 597
G L+FQ G F R++ CP+ P G R GD ++ G+
Sbjct: 661 GHVARLEFQTDHSTGKRGFNITFTTF-----RHNECPDPGVPVNGKR---FGDSLQLGSS 712
Query: 598 LTYQCEPGY-ELLGSDILTC---QWDLSWSAAPPACQKIMTCADP--GEIANGHRTASDA 651
+++ C+ G+ GS+ +TC + + W++A ++ C P G + + T
Sbjct: 713 ISFLCDEGFLGTQGSETITCVLKEGSVVWNSA------VLRCEAPCGGHLTSPSGTILSP 766
Query: 652 GFPVGSHVQYRCL------PGYSLE-----------------------GAAMLTCYSRDT 682
G+P C PGY ++ A ++ Y T
Sbjct: 767 GWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVY-HGT 825
Query: 683 GTPKW------------------SD-----RVPKCALKYEPCLNPGVPENGYQTLYKHHY 719
P++ SD R L+ + CL+PG+P NG + + + +
Sbjct: 826 QVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQR--HGNDF 883
Query: 720 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDP 779
G + F C G+ L + C P QW+ P C+ + + P
Sbjct: 884 YVGALVTFSCDSGYTLSDGEPLECEPNF--QWSRALPSCEALCGGFIQGSSGTILSPGFP 941
Query: 780 SRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNP 839
NL ++ G GV+ + F H Y IT F+ P
Sbjct: 942 --DFYPNNLNCTWIIETS----HGKGVFFTF------HTFHLESGHDYLLITENGSFTQP 989
Query: 840 LYEAGDTR 847
L + +R
Sbjct: 990 LRQLTGSR 997
Score = 117 bits (294), Expect = 3e-26
Identities = 150/576 (26%), Positives = 211/576 (36%), Gaps = 79/576 (13%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC 275
++SCG P P +G T G TA F C+SGY L G C+ NG W+G C
Sbjct: 2655 IISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGL---WSGSEVRC 2711
Query: 276 MASCGGTIHNATLGRIVSPEP---GGAVGPNLTCRW--VIEAAEGRRLHLHFERVSLDED 330
+A GT PEP G G N + R V + G RL R+ +
Sbjct: 2712 LAGHCGT-----------PEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDH 2760
Query: 331 NDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 390
+ SG +P ++ P + D+ ++ + L+
Sbjct: 2761 H-----WSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCG 2815
Query: 391 EDRCFAPFLAHGNVTTT----DP-----------EYRPGALATFSCLPGYALEPPGPPNA 435
D + L H + T+ DP + PG + FSC G+ L +
Sbjct: 2816 LDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLR-----GS 2870
Query: 436 IECVDPTEPHWNDTEPACKAMCGGELSEP--AGVVLSPDWPQSYSPGQDCVWGVHVQEEK 493
E W+ ++P C + G P A VV S S S +C G +
Sbjct: 2871 SERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATG-- 2928
Query: 494 RILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDL----TLQFQAP 549
L R + + G P V+ P L G D T+ +Q
Sbjct: 2929 --------LLSRHCSVNGTWTGSDPECLVI-NCGDPGIPANGLRLGNDFRYNKTVTYQCV 2979
Query: 550 PGPPNPGLGQGFVLHFKEVPRNDTCPEL------PPPEWGWRTASHGDLIRGTVLTYQCE 603
PG + K+ N T P PPP D + G+ +TY C
Sbjct: 2980 PGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACL 3039
Query: 604 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC 663
GY+L + TC+ + SW+ P C + C DPG + G R D GF S V + C
Sbjct: 3040 EGYQLSLPAVFTCEGNGSWTGELPQCFPVF-CGDPGVPSRGRR--EDRGFSYRSSVSFSC 3096
Query: 664 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCA-LKYEPCLNPGVPENGYQTLYKHHYQAG 722
P L G+ C S T WS P C C +PGVP+ G Q YQ G
Sbjct: 3097 HPPLVLVGSPRRFCQSDGT----WSGTQPSCIDPTLTTCADPGVPQFGIQN-NSQGYQVG 3151
Query: 723 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
++ F C +G+ L G T TC+P W+ PP C
Sbjct: 3152 STVLFRCQKGYLLQGSTTRTCLPN--LTWSGTPPDC 3185
Score = 102 bits (253), Expect = 2e-21
Identities = 139/573 (24%), Positives = 200/573 (34%), Gaps = 129/573 (22%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
L+SCG P P H +S G + C L G T +C G W G P C
Sbjct: 2771 LVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMC--GLDGHWTGSLPHCS 2828
Query: 277 ASCGGTI-------HNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 329
+ G H LG S +PG + + V+ + R +
Sbjct: 2829 GTSVGVCGDPGIPAHGIRLGD--SFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQP 2886
Query: 330 DNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY--------VELLSE------- 374
+ + + G+P + + SD GL+ + +Y LLS
Sbjct: 2887 ECGVISCGNPGTPSNARVVFSD-------GLVFSSSIVYECREGYYATGLLSRHCSVNGT 2939
Query: 375 -TPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPP 433
T ++P L + C P + N ++R T+ C+PGY +E
Sbjct: 2940 WTGSDPECLVIN--------CGDPGIP-ANGLRLGNDFRYNKTVTYQCVPGYMMESHRV- 2989
Query: 434 NAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 493
+ + C + WN T+P CKA+ + +P ++ P G D +WG V
Sbjct: 2990 SVLSCTK--DRTWNGTKPVCKAL----MCKPPPLI-----PNGKVVGSDFMWGSSVTYA- 3037
Query: 494 RILLQVEILNVREGDMLTL-----FDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQA 548
EG L+L +G+G L P F
Sbjct: 3038 ----------CLEGYQLSLPAVFTCEGNGSWTGEL----------------PQCFPVFCG 3071
Query: 549 PPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYEL 608
PG P+ G R G R +V ++ C P L
Sbjct: 3072 DPGVPSRG----------------------------RREDRGFSYRSSV-SFSCHPPLVL 3102
Query: 609 LGSDILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG 666
+GS CQ D +WS P+C + TCADPG G + S G+ VGS V +RC G
Sbjct: 3103 VGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQ-GYQVGSTVLFRCQKG 3161
Query: 667 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLR 726
Y L+G+ TC T WS P C + C P P + G +L
Sbjct: 3162 YLLQGSTTRTCLPNLT----WSGTPPDCVPHH--CRQPETPTHANVGALDLP-SMGYTLI 3214
Query: 727 FFCYEGFELIG-EVTITCVPGHPSQWTSQPPLC 758
+ C EGF L G TC WT +PP+C
Sbjct: 3215 YSCQEGFSLKGGSEHRTCKAD--GSWTGKPPIC 3245
Score = 99.0 bits (245), Expect = 2e-20
Identities = 100/396 (25%), Positives = 156/396 (39%), Gaps = 17/396 (4%)
Query: 101 VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 160
V C NI+ G V SP SP S + DC + I V G+G+ + + L + +
Sbjct: 2180 VPCGGNITSSNGTVYSPGFPSPYSSSQ---DCVWLITVPIGHGVRLNLSLLQTEPSGDFI 2236
Query: 161 VLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSC 220
+ G APRL + + + + ++S +N++LL F GG F I + AY L+
Sbjct: 2237 TI-WDGPQQTAPRLGVFTRSMAK-KTVQSSSNQVLLKFHRD-AATGGIFAIAFSAYPLTK 2293
Query: 221 GFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 277
PP VT + + G + C G+ L G E L C GT + G P C
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353
Query: 278 SC-GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMV 336
C + + G I+S G+ TC W++ + L E ++ D +
Sbjct: 2354 HCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEI 2413
Query: 337 RSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 396
G S SP++ + + S + S+Y+ S+ N +R+ A C
Sbjct: 2414 FDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA---PYCSL 2470
Query: 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKA 455
P +PG F C GY L G AI P H W++ P C+A
Sbjct: 2471 PRAPLHGFILGQTSTQPGGSIHFGCNAGYRL--VGHSMAICTRHPQGYHLWSEAIPLCQA 2528
Query: 456 M-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQ 490
+ CG + G+V ++ C G H+Q
Sbjct: 2529 LSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQ 2564
Score = 75.9 bits (185), Expect = 2e-13
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 10/165 (6%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
GTV+ + CE G+ L GS TCQ + SWS + P C +++C +PG +N SD G
Sbjct: 2854 GTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC-GVISCGNPGTPSNARVVFSD-GLV 2911
Query: 655 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 714
S + Y C GY G C T W+ P+C + C +PG+P NG +
Sbjct: 2912 FSSSIVYECREGYYATGLLSRHCSVNGT----WTGSDPECLV--INCGDPGIPANGLR-- 2963
Query: 715 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
+ ++ +++ + C G+ + W P+CK
Sbjct: 2964 LGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCK 3008
Score = 73.2 bits (178), Expect = 1e-12
Identities = 50/168 (29%), Positives = 75/168 (44%), Gaps = 13/168 (7%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 653
RG+V+ YQC G+ L+G + CQ D WS P C +++C PG + H S +
Sbjct: 2735 RGSVV-YQCNAGFRLIGMSVRICQQDHHWSGKTPFC-VLVSCGHPG--SPPHSQMSGDSY 2790
Query: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCA-LKYEPCLNPGVPENGYQ 712
VG+ V+Y C+ +L G + C W+ +P C+ C +PG+P +G +
Sbjct: 2791 TVGAVVRYSCIGKRTLVGNSTRMCGL----DGHWTGSLPHCSGTSVGVCGDPGIPAHGIR 2846
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 760
+ G +RF C G L G TC W+ P C V
Sbjct: 2847 --LGDSFDPGTVMRFSCEAGHVLRGSSERTCQAN--GSWSGSQPECGV 2890
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/215 (26%), Positives = 89/215 (41%), Gaps = 20/215 (9%)
Query: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 515
C +L P G V SP +P Y +C W + +E+ RI L + + E D+L++FDG
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85
Query: 516 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC- 574
+ +L G Q ++S+ L+L+ + QGF ++ +P + TC
Sbjct: 86 PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVS----AQGFHATYEVLP-SHTCG 140
Query: 575 --PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPA 628
LP T + GD +R Y C G+ L G +LTC + +W P+
Sbjct: 141 NPGRLPNGIQQGSTFNLGDKVR-----YSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195
Query: 629 CQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC 663
C+ C G + S FP H C
Sbjct: 196 CRADDACG--GTLRGQSGIISSPHFPSEYHNNADC 228
Score = 47.4 bits (111), Expect = 6e-05
Identities = 49/159 (30%), Positives = 63/159 (39%), Gaps = 19/159 (11%)
Query: 141 GYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQ 199
G + I Q + S + VL G PG P + G V+R S + L
Sbjct: 2750 GMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGN 2809
Query: 200 SPRVPRGGGFRIHYQAYLLSC--------GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQ 251
S R+ G H+ L C G P PAHG PG F C++G+
Sbjct: 2810 STRMC---GLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHV 2866
Query: 252 LQGEETLIC-LNGTRPSWNGETPSC-MASCG--GTIHNA 286
L+G C NG SW+G P C + SCG GT NA
Sbjct: 2867 LRGSSERTCQANG---SWSGSQPECGVISCGNPGTPSNA 2902
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/134 (29%), Positives = 54/134 (40%), Gaps = 6/134 (4%)
Query: 706 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLCKVAYE 763
VPE Y + G +RF C G+ L G I C VPG +QW P C V
Sbjct: 1738 VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCG 1797
Query: 764 ELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSG 823
L R+ + P L N I++P G I + V + T+ SL F G
Sbjct: 1798 GNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQI--QVVSFVTEQNWDSLEVFDG 1855
Query: 824 SHSYSPITVESDFS 837
+ + +T+ FS
Sbjct: 1856 AD--NTVTMLGSFS 1867
Score = 38.5 bits (88), Expect = 0.027
Identities = 18/64 (28%), Positives = 28/64 (43%)
Query: 214 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETP 273
+ +++CG P PA+G D T T+ C GY ++ + +WNG P
Sbjct: 2946 ECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKP 3005
Query: 274 SCMA 277
C A
Sbjct: 3006 VCKA 3009
Score = 32.0 bits (71), Expect = 2.5
Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 787 NLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYE 842
++A AIL+P +I+ G +Y+Y + + K F+G + V + F NP+Y+
Sbjct: 3410 SVAAAILVPFIALIIAGFVLYLYKHRRRPK--VPFNGYAGHENTNVRATFENPMYD 3463
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 226 bits (575), Expect = 9e-59
Identities = 166/535 (31%), Positives = 247/535 (46%), Gaps = 25/535 (4%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C ++ EG + SP+ S +C Y I G GI ++ ++ L + + L V
Sbjct: 1105 CGASVKGNEGTLLSPNFPSNYDNNH---ECIYKIETEAGKGIHLRTRSFQLFEGDTLKVY 1161
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLSCG 221
G S + +LG +L S +N L L F + GF++ Y ++ L+ C
Sbjct: 1162 DGKDSSSRPLGTFTKNELLG--LILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCE 1219
Query: 222 FPPRPAHGDVSVTDLHPGGTATFH-CDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
P P +G + H T + C+ GY + G TL CL+G R W+ PSC+A CG
Sbjct: 1220 DPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECG 1279
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
G IH AT GRI+SP NL C W+IEA G+ + LHF + +D L V G
Sbjct: 1280 GQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGP 1339
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
++ + +PE + S SL ++ S+ + S++F C P +
Sbjct: 1340 VDSDILLKEWSGSALPE-DIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMP 1398
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEP-HWNDTEPACKAMCGG 459
N T G TF C PGY L+ I CV W P C A CGG
Sbjct: 1399 Q-NGTRYGDSREAGDTVTFQCDPGYQLQGQA---KITCVQLNNRFFWQPDPPTCIAACGG 1454
Query: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518
L+ PAGV+LSP++PQ Y PG++C W V V + I L + N+ D L +++G+
Sbjct: 1455 NLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDS 1514
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578
++ ++ +G Q R+ SSG L L F++ + GL GF + FKE PR + C +
Sbjct: 1515 NSPLIGSYQGSQAPERIESSGNSLFLAFRS---DASVGL-SGFAIEFKEKPR-EACFDPG 1569
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 629
G R + D G+ +TYQC+ GY++L +TC SW P+C
Sbjct: 1570 NIMNGTRVGT--DFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 211 bits (537), Expect = 2e-54
Identities = 196/729 (26%), Positives = 303/729 (41%), Gaps = 107/729 (14%)
Query: 101 VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 160
V C+ N ++ G + SP P L +C + I V G GI+IQV + Q + L
Sbjct: 1801 VPCSGNFTQRRGTILSPGYPEPYGNNL---NCIWKIIVTEGSGIQIQVISFATEQNWDSL 1857
Query: 161 VLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLS 219
+ GG APRL + S +L S +N+L LHFQS GF + Y+ L +
Sbjct: 1858 EIHDGGDV-TAPRLGSFSGTTVPA-LLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAA 1915
Query: 220 CGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 278
C P P++ + + D + +F C+ GY LQG + C+ GT WN +P C+A+
Sbjct: 1916 CQEPALPSNS-IKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIAT 1974
Query: 279 CGGTIHNATLGRIV-SPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
CGGT+ +TLG ++ SP G+ NL C W I G H+ F S + ++D L ++
Sbjct: 1975 CGGTL--STLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQ 2032
Query: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC-FA 396
+G SP+I D+P L+S + S+ N L ++A+E C
Sbjct: 2033 NGPYHTSPMIGQFSGTDLPA-ALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDP 2091
Query: 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 456
P +G + +D Y G +F C PGY L G P + C +WN P C A
Sbjct: 2092 PPFQNGYMINSD--YSVGQSVSFECYPGYILI--GHP-VLTCQHGINRNWNYPFPRCDAP 2146
Query: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRI-----LLQVEILNVREGDMLT 511
CG ++ G + SP +P Y +DC+W + V + LLQ E +N D +
Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIA 2202
Query: 512 LFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK--EVP 569
++DG ++ L G SS + L+F + + G FVL+F ++
Sbjct: 2203 VWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHS-----DFSNGGFFVLNFHAFQLK 2257
Query: 570 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQW--DLSWSAAPP 627
+ P +P E D G + YQC PGY L+G+DILTC+ L + + P
Sbjct: 2258 KCQPPPAVPQAE---MLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLP 2314
Query: 628 ACQK--------------IMTCADPGEIANGHRTA-------------------SDAGFP 654
C+ I++ PG N + S+ F
Sbjct: 2315 TCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFD 2374
Query: 655 V------------------GSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV----P 692
G+H + ++ + +S D T K ++ P
Sbjct: 2375 ALEVFDGSSGQSPLLVVLSGNHTEQ---SNFTSRSNQLYLRWSTDHATSKKGFKIRYAAP 2431
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQ 750
C+L + P N G+ L + G + +FC G+ ++G TC P Q
Sbjct: 2432 YCSLTH-PLKNGGI-------LNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQ 2483
Query: 751 WTSQPPLCK 759
W S PLC+
Sbjct: 2484 WDSLTPLCQ 2492
Score = 208 bits (529), Expect = 2e-53
Identities = 159/557 (28%), Positives = 248/557 (44%), Gaps = 38/557 (6%)
Query: 112 GYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLA 171
G + SP +P L CT+ I PG I + + ++L + G P +
Sbjct: 1288 GRILSPGYPAPYDNNL---HCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDG--PVDS 1342
Query: 172 PRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPAHGD 230
LL S + + S N L L F S GF I + + + C P P +G
Sbjct: 1343 DILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQNGT 1402
Query: 231 VSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNATLG 289
G T TF CD GYQLQG+ + C+ R W + P+C+A+CGG + G
Sbjct: 1403 RYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNL-TGPAG 1461
Query: 290 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 349
I+SP P C W ++ + L F+ +++ D L + G SP+I
Sbjct: 1462 VILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGS 1521
Query: 350 SDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV---TT 406
PER + S SL++ S+ ++ F+ + CF P GN+ T
Sbjct: 1522 YQGSQAPER-IESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDP----GNIMNGTR 1576
Query: 407 TDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE--PHWNDTEPACKAMCGGELSEP 464
+++ G+ T+ C GY + P ++I CV + P W+ P+C A CGG+ +
Sbjct: 1577 VGTDFKLGSTITYQCDSGYKILDP---SSITCVIGADGKPSWDQVLPSCNAPCGGQYTGS 1633
Query: 465 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA 524
GVVLSP++P +Y+ GQ C++ + V +E + Q D+ LFDG AR+L+
Sbjct: 1634 EGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLS 1693
Query: 525 QLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPR-NDT-CPELPPPE 581
L G L L++ + L+F A G +GF ++ VPR +DT C +P P
Sbjct: 1694 SLSGSHSGETLPLATSNQILLRFSAKSG----ASARGFHFVYQAVPRTSDTQCSSVPEPR 1749
Query: 582 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQKIMTCAD 637
+G R S + G+++ ++C PGY L GS L CQ W+ P+C ++ C+
Sbjct: 1750 YGRRIGS--EFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC--VVPCS- 1804
Query: 638 PGEIANGHRTASDAGFP 654
G T G+P
Sbjct: 1805 -GNFTQRRGTILSPGYP 1820
Score = 187 bits (475), Expect = 4e-47
Identities = 188/743 (25%), Positives = 292/743 (39%), Gaps = 89/743 (11%)
Query: 82 ETTTTIITTTTVTTTVTSP---VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHV 138
E+ T I+ V + T P C +++ G + P +L C + I
Sbjct: 735 ESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSL---HCEWIIEA 791
Query: 139 YPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHF 198
PG+ I+I + L + G P + L+ Q L S N + L F
Sbjct: 792 KPGHSIKITFDRFQTEVNYDTLEVRDG--PASSSPLIGEYHGTQAPQFLISTGNFMYLLF 849
Query: 199 QSPRVPRGGGFRIHYQAYLL---SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGE 255
+ GF IHY++ L SC P P +G D T TF CD GY L +
Sbjct: 850 TTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDD 909
Query: 256 ETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEG 315
E L+C + WN PSC A CGG I + G ++SP +L C W IE + G
Sbjct: 910 EPLVCERNHQ--WNHALPSCDALCGGYIQGKS-GTVLSPGFPDFYPNSLNCTWTIEVSHG 966
Query: 316 RRLHLHFERVSLDEDNDRLMVRSGGSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLS 373
+ + + F L+ +D L++ GS PV + S + + GL + + + +S
Sbjct: 967 KGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTA-QLRFIS 1025
Query: 374 ETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPP 433
+ + ++ F ++ + C P + + + G TFSC GY LE
Sbjct: 1026 DFSISYEGFNITFSEYDLEPCDDPGVPAFS-RRIGFHFGVGDSLTFSCFLGYRLEGA--- 1081
Query: 434 NAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 493
+ C+ W+ P C A CG + G +LSP++P +Y +C++ + + K
Sbjct: 1082 TKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGK 1141
Query: 494 RILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPD-LTLQFQAPPGP 552
I L+ + EGD L ++DG S+R L + +L+S + L L+F
Sbjct: 1142 GIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSD 1201
Query: 553 PNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD 612
+ QGF L + C + P +G+R G TV+ Y C PGY + GS+
Sbjct: 1202 TD----QGFQLTYTSFDL-VKCEDPGIPNYGYRIRDEGH-FTDTVVLYSCNPGYAMHGSN 1255
Query: 613 ILTCQWDLS-----WSAAPPACQKIMTC-------------------------------- 635
LTC LS W P+C I C
Sbjct: 1256 TLTC---LSGDRRVWDKPLPSC--IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIE 1310
Query: 636 ADPGEIANGHRTASDAGF----------PVGSHVQYRCLPGYSLEG------AAMLTCYS 679
ADPG+ + H D PV S + + G +L ++ +
Sbjct: 1311 ADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFD 1370
Query: 680 RDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEV 739
D K + C +PG+P+NG T Y +AG+++ F C G++L G+
Sbjct: 1371 SDFFISKSGFSIQFSTSIAATCNDPGMPQNG--TRYGDSREAGDTVTFQCDPGYQLQGQA 1428
Query: 740 TITCVP-GHPSQWTSQPPLCKVA 761
ITCV + W PP C A
Sbjct: 1429 KITCVQLNNRFFWQPDPPTCIAA 1451
Score = 178 bits (452), Expect = 2e-44
Identities = 154/585 (26%), Positives = 250/585 (42%), Gaps = 29/585 (4%)
Query: 79 GEEETTTTIITTTTVTTTVTSPVL----CNNNISEGEGYVESPDLGSPVSRTLGLLDCTY 134
G + T +T T + P+ C +N+ G + SP+ PV C +
Sbjct: 384 GSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNY--PVQYEDNA-HCVW 440
Query: 135 SIHVY-PGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNR 193
I P I++ + L + + L + G G +L + ++ S +N+
Sbjct: 441 VITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQ 500
Query: 194 LLLHFQSPRVPRGGGFRIHYQAYLL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQL 252
+ LH QS GF+ YQ CG P PA+G + + G T TF C + ++L
Sbjct: 501 MWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFEL 560
Query: 253 QGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEA 312
GE + C + W+G PSC+ SC A+ G I+SP G N+ C W+I +
Sbjct: 561 VGERVITCQQNNQ--WSGNKPSCVFSCFFNF-TASSGIILSPNYPEEYGNNMNCVWLIIS 617
Query: 313 AEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELL 372
G R+HL F ++ D L V+ G V+ ++VP + L S + +E
Sbjct: 618 EPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQ-LASSGHIVRLEFQ 676
Query: 373 SETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGP 432
S+ ++ + F ++ C P + D + G+ +F C G+ ++ G
Sbjct: 677 SDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGD-RFLLGSSVSFHCDDGF-VKTQGS 734
Query: 433 PNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEE 492
+ + W+ T P C+A CGG L+ +GV+L P WP Y C W + +
Sbjct: 735 ESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPG 794
Query: 493 KRILLQVEILNVREG-DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPG 551
I + + D L + DG S+ ++ + G Q + L+S+G + L F
Sbjct: 795 HSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTT--- 851
Query: 552 PPNPGLGQGFVLHFKEVP-RNDTCPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELL 609
N GF++H++ V +D+C + P G R GD IR TV T+ C+PGY L
Sbjct: 852 -DNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHG--GDFGIRSTV-TFSCDPGYTLS 907
Query: 610 GSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
+ L C+ + W+ A P+C + C G I T GFP
Sbjct: 908 DDEPLVCERNHQWNHALPSCDAL--CG--GYIQGKSGTVLSPGFP 948
Score = 178 bits (452), Expect = 2e-44
Identities = 177/722 (24%), Positives = 274/722 (37%), Gaps = 95/722 (13%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + EG V SP+ P + T G + C YSI V + + Q + + +
Sbjct: 1626 CGGQYTGSEGVVLSPNY--PHNYTAGQI-CLYSITVPKEFVVFGQFAYFQTALNDLAELF 1682
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPT-NRLLLHFQSPRVPRGGGFRIHYQAYLLS-- 219
G + RLL++ S G+ L T N++LL F + GF YQA +
Sbjct: 1683 DGTHAQA---RLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSD 1739
Query: 220 --CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN--GTRPSWNGETPSC 275
C P P +G ++ G F C+ GY LQG L C + WN PSC
Sbjct: 1740 TQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
+ C G G I+SP G NL C W I EG + + + +++ D L
Sbjct: 1800 VVPCSGNFTQRR-GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLE 1858
Query: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395
+ GG +P + VP L S + LY+ S+ L ++ C
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPAL-LNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQ 1917
Query: 396 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKA 455
P L ++ D Y + +F C PGY L+ + I C+ T WN P C A
Sbjct: 1918 EPALPSNSIKIGD-RYMVNDVLSFQCEPGYTLQGR---SHISCMPGTVRRWNYPSPLCIA 1973
Query: 456 MCGGELSEPAGVVLSPDWPQSYSPGQDCVW--------GVHVQEEKRILLQVEILNVREG 507
CGG LS GV+LSP +P SY DC W G H+Q +
Sbjct: 1974 TCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQ-------FLNFSTEANH 2026
Query: 508 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 567
D L + +G ++ ++ Q G LLS+ + + F + QGF L ++
Sbjct: 2027 DFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNR----QGFKLAYQA 2082
Query: 568 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL--SWSAA 625
+ CP+ PP + G+ S D G ++++C PGY L+G +LTCQ + +W+
Sbjct: 2083 YELQN-CPDPPPFQNGYMINS--DYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYP 2139
Query: 626 PPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCL------PGYSL---------- 669
P C C NG T GFP + C+ PG+ +
Sbjct: 2140 FPRCD--APCGYNVTSQNG--TIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE 2195
Query: 670 -------------EGAAMLTCYSRDTGTPKWSDRVPKCALKY------------------ 698
+ + L +S +T + LK+
Sbjct: 2196 AVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQ 2255
Query: 699 -EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757
+ C P ++ G+ +++ C+ G+ L+G +TC Q+ P
Sbjct: 2256 LKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315
Query: 758 CK 759
C+
Sbjct: 2316 CE 2317
Score = 172 bits (437), Expect = 9e-43
Identities = 175/716 (24%), Positives = 269/716 (37%), Gaps = 86/716 (12%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N + G + SP+ + +C + I PG I + ++ + + L +
Sbjct: 585 CFFNFTASSGIILSPNYPEEYGNNM---NCVWLIISEPGSRIHLIFNDFDVEPQFDFLAV 641
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLSCG 221
G + +L S L S + + L FQS G GF I Y + C
Sbjct: 642 KDDGISDIT--VLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECH 699
Query: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGY-QLQGEETLIC-LNGTRPSWNGETPSCMASC 279
P P +G G + +FHCD G+ + QG E++ C L W+ P C A C
Sbjct: 700 DPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPC 759
Query: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339
GG + A+ G I+ P G +L C W+IEA G + + F+R + + D L VR G
Sbjct: 760 GGHL-TASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDG 818
Query: 340 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEA--FEEDRCFAP 397
+ SP+I + P+ LIS +Y+ ++ + + + +E+ E D C P
Sbjct: 819 PASSSPLIGEYHGTQAPQ-FLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDP 877
Query: 398 FL-----AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 452
+ HG ++ + TFSC PGY L P V WN P+
Sbjct: 878 GIPVNGHRHGG------DFGIRSTVTFSCDPGYTLSDDEP-----LVCERNHQWNHALPS 926
Query: 453 CKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 512
C A+CGG + +G VLSP +P Y +C W + V K + + ++ L
Sbjct: 927 CDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLL 986
Query: 513 FDGDGPSARVLAQLRG---PQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 569
DG + +A+L G P + L L+F + +GF + F E
Sbjct: 987 ITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISY----EGFNITFSEYD 1042
Query: 570 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPP 627
+ C + P + R H + G LT+ C GY L G+ LTC WSA P
Sbjct: 1043 L-EPCDDPGVPAFSRRIGFHFGV--GDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLP 1099
Query: 628 AC------------QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAML 675
C +++ P N H G + R EG +
Sbjct: 1100 RCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLK 1159
Query: 676 TCYSRD---------------------TGTPKW-------SDRVPKCALKYE-----PCL 702
+D T W SD L Y C
Sbjct: 1160 VYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCE 1219
Query: 703 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
+PG+P GY+ + H+ + + C G+ + G T+TC+ G W P C
Sbjct: 1220 DPGIPNYGYRIRDEGHF-TDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSC 1274
Score = 160 bits (404), Expect = 6e-39
Identities = 196/796 (24%), Positives = 295/796 (37%), Gaps = 130/796 (16%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N++ G + SP+ P +C + + V P + I + ++ N+ + L +
Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGK---ECDWRVKVNPDFVIALIFKSFNMEPSYDFLHI 1508
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPT------NRLLLHFQSPRVPRGGGFRIHYQAY 216
G +NS ++G Q ++P N L L F+S GF I ++
Sbjct: 1509 YEGED--------SNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEK 1560
Query: 217 LLSCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 273
F P V TD G T T+ CDSGY++ ++ C+ G +PSW+ P
Sbjct: 1561 PREACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620
Query: 274 SCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 333
SC A CGG + + G ++SP C + I + + F
Sbjct: 1621 SCNAPCGGQ-YTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQ------- 1672
Query: 334 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 393
+ L+ + D R L S + S E L +N +LL ++ R
Sbjct: 1673 -------TALNDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASAR 1725
Query: 394 CFAPFLAHGNVTTTDP----------------EYRPGALATFSCLPGYALEPPGPPNAIE 437
F F+ T+D E+ G++ F C PGY L+ A+
Sbjct: 1726 GFH-FVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGS---TALH 1781
Query: 438 C--VDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRI 495
C V WNDT P+C C G ++ G +LSP +P+ Y +C+W + V E I
Sbjct: 1782 CQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGI 1841
Query: 496 LLQV-EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPN 554
+QV + D L + DG +A L G L S+ L L FQ+
Sbjct: 1842 QIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVA- 1900
Query: 555 PGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGD-LIRGTVLTYQCEPGYELLGSDI 613
GF L +K V C E P + GD + VL++QCEPGY L G
Sbjct: 1901 ---AAGFHLEYKTVGLA-ACQEPALPS---NSIKIGDRYMVNDVLSFQCEPGYTLQGRSH 1953
Query: 614 LTCQWDL--SWSAAPPACQKIMTCAD--------------PGEIANGHRTASDAGFPVG- 656
++C W+ P C I TC PG N P+G
Sbjct: 1954 ISCMPGTVRRWNYPSPLC--IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGY 2011
Query: 657 -SHVQ-------------------YRCLP------GYSLEGAAMLTCYSR------DTGT 684
+H+Q Y P G L A + T + D
Sbjct: 2012 GAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQ 2071
Query: 685 PKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 744
+ ++ A + + C +P +NGY + Y G+S+ F CY G+ LIG +TC
Sbjct: 2072 NRQGFKLAYQAYELQNCPDPPPFQNGY--MINSDYSVGQSVSFECYPGYILIGHPVLTCQ 2129
Query: 745 PGHPSQWTSQPPLCKV--AYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVL 802
G W P C Y N + P E L I L + +
Sbjct: 2130 HGINRNWNYPFPRCDAPCGYNVTSQNGTI-----YSPGFPDEYPILKDCIWL---ITVPP 2181
Query: 803 GSGVYIYYTKLQGKSL 818
G GVYI +T LQ +++
Sbjct: 2182 GHGVYINFTLLQTEAV 2197
Score = 139 bits (350), Expect = 1e-32
Identities = 155/573 (27%), Positives = 226/573 (39%), Gaps = 69/573 (12%)
Query: 103 CNNNISEGEGYVESPDL--GSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 160
C + G +ESP G P +CT+ I I++ T L ++ ++L
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYP-----NYANCTWIIITGERNRIQLSFHTFALEEDFDIL 86
Query: 161 VLAGGGSP--GLAPRLLA---NSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 215
+ G L RL SS++ G +L L F + GF+ Y+
Sbjct: 87 SVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILT-------LWFTTDFAVSAQGFKALYEV 139
Query: 216 YLL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL--NGTRPSWNGET 272
+CG P G + T + G + C GY L+G L C+ G SW+
Sbjct: 140 LPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPA 199
Query: 273 PSCMA--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED 330
P C A +CGGT+ T I SP N C W I A G + L F L+E
Sbjct: 200 PFCRAEGACGGTL-RGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG 258
Query: 331 NDRLMVRSGGSPL---------SPVIYDSD------MDDVPERGLISDAQ---------- 365
D L + +P SPVI + D R +AQ
Sbjct: 259 YDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELK 318
Query: 366 SLYVELLSETPAN--PLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLP 423
S V++L + +LS A D C P + R GA FSC
Sbjct: 319 SRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCED 378
Query: 424 GYALEPPGPPNAIEC--VDPTEPHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPG 480
Y L+ +I C V T W+D P C+A CG L P+GV+ SP++P Y
Sbjct: 379 NYVLQ---GSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDN 435
Query: 481 QDCVWGVHVQE-EKRILLQVEILNVREG-DMLTLFDGD--GPSARVLAQLRGPQPRRRLL 536
CVW + + +K I L E + G D LT+ D G + VL L G ++
Sbjct: 436 AHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 537 SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGT 596
S + L Q+ +P GF ++E+ + C + P +G RT S + G
Sbjct: 496 SMSNQMWLHLQSDDSIGSP----GFKAVYQEIEKGG-CGDPGIPAYGKRTGS--SFLHGD 548
Query: 597 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
LT++C +EL+G ++TCQ + WS P+C
Sbjct: 549 TLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 131 bits (330), Expect = 2e-30
Identities = 161/680 (23%), Positives = 261/680 (38%), Gaps = 54/680 (7%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N++ G + SP G P + L DC + I V PG+G+ I L + + +
Sbjct: 2147 CGYNVTSQNGTIYSP--GFPDEYPI-LKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAV 2203
Query: 163 AGG---GSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS 219
G SP L + + ++ L + S TN++LL F S GG F +++ A+ L
Sbjct: 2204 WDGPDQNSPQLG--VFSGNTAL---ETAYSSTNQVLLKFHSD-FSNGGFFVLNFHAFQLK 2257
Query: 220 -CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
C PP ++ D G + C GY L G + L C ++ + G P+C
Sbjct: 2258 KCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCE 2317
Query: 277 ASC-GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
A C + + G I+SP G + TC W I+ + + + ++ D L
Sbjct: 2318 AQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALE 2377
Query: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395
V G S SP++ + + S + LY+ ++ + +R+ A C
Sbjct: 2378 VFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA---PYCS 2434
Query: 396 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACK 454
G+ + C PGY + G NA +P + W+ P C+
Sbjct: 2435 LTHPLKNGGILNRTAGAVGSKVHYFCKPGYRM--VGHSNATCRRNPLGMYQWDSLTPLCQ 2492
Query: 455 AM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQ--EEKRILLQVEILNVREGDMLT 511
A+ CG S G ++ +C G ++ ++ + Q + L +G T
Sbjct: 2493 AVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPT 2552
Query: 512 LFDGDGPSA----------RVLAQLRGPQPRRRLLSSGPDLTLQ-FQAPPGPPNPGLGQG 560
PS R+++ + LLS P L+ ++ N G
Sbjct: 2553 CKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQAN---GTW 2609
Query: 561 FVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL 620
+ + R +C L P G + + + G + C GY L+GS + C +
Sbjct: 2610 NIGDERPSCRVISCGSLSFPPNGNKIGTL--TVYGATAIFTCNTGYTLVGSHVRECLANG 2667
Query: 621 SWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSR 680
WS + C C P I NGH S GF V Y+C PG+ L G ++ C
Sbjct: 2668 LWSGSETRC-LAGHCGSPDPIVNGH--ISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQ- 2723
Query: 681 DTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVT 740
KWS + P C C +PG P +G+ + + + F C G+ L G
Sbjct: 2724 ---DHKWSGQTPVCV--PITCGHPGNPAHGFTN--GSEFNLNDVVNFTCNTGYLLQGVSR 2776
Query: 741 ITCVPGHPSQWTSQPPLCKV 760
C QW+S P C+V
Sbjct: 2777 AQCRSN--GQWSSPLPTCRV 2794
Score = 127 bits (319), Expect = 4e-29
Identities = 206/918 (22%), Positives = 317/918 (34%), Gaps = 169/918 (18%)
Query: 34 EILPEPGSETPTVASEALAELLHGALLRRGPEMGY--LPGPPLGPEGGEEETTTTIITTT 91
E+LP P E L +LHG G ++ Y LPG L G T +
Sbjct: 138 EVLPSHTCGNP---GEILKGVLHGTRFNIGDKIRYSCLPGYILE---GHAILTCIVSPGN 191
Query: 92 TVTTTVTSPVL-----CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEI 146
+ +P C + + SP S DCT++I PG I +
Sbjct: 192 GASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNA---DCTWTILAEPGDTIAL 248
Query: 147 QVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPT----NRLLLHFQSPR 202
L + + L ++G +P S+ G L SP N L LHF S
Sbjct: 249 VFTDFQLEEGYDFLEISGTEAP----------SIWLTGMNLPSPVISSKNWLRLHFTSDS 298
Query: 203 VPRGGGFRIHYQAY----LLSCGFPPRPAH------------GDVSVTDLHP-------- 238
R GF +Q L S G P+ G V+D+ P
Sbjct: 299 NHRRKGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENG 358
Query: 239 ----------GGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSCMA-SCGGTIHN 285
G F C+ Y LQG +++ C + T +W+ P C A +CG +
Sbjct: 359 RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRG 418
Query: 286 ATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLMVRSGGS--P 342
+ G I SP N C WVI + + + L FE L+ D L V G
Sbjct: 419 PS-GVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGD 477
Query: 343 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL-AH 401
V+Y VP+ ++S + +++ L S+ ++ E+ C P + A+
Sbjct: 478 TRSVLYVLTGSSVPDL-IVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAY 536
Query: 402 GNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGEL 461
G T + G TF C + L I C + W+ +P+C C
Sbjct: 537 GK--RTGSSFLHGDTLTFECPAAFELVGE---RVITCQQNNQ--WSGNKPSCVFSCFFNF 589
Query: 462 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPSA 520
+ +G++LSP++P+ Y +CVW + + RI L +V + D L + D
Sbjct: 590 TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDI 649
Query: 521 RVLAQLRGPQPRRRLLSSGPDLTLQFQAP----------------------PGPPNPG-- 556
VL G + +L SSG + L+FQ+ PG P G
Sbjct: 650 TVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRR 709
Query: 557 ------LGQGFVLHFKE-------------------VPRNDTCPELPPPEWGWRTASHGD 591
LG H + V + T P P G TAS G
Sbjct: 710 FGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGV 769
Query: 592 LIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM-------TCADPGEIANG 644
++ PG+ D L C+W + A P KI D E+ +G
Sbjct: 770 IL---------PPGWPGYYKDSLHCEWIIE--AKPGHSIKITFDRFQTEVNYDTLEVRDG 818
Query: 645 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV--PKCALKYEPCL 702
++S +G + + G M ++ D + L+ + CL
Sbjct: 819 PASSSPL---IGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCL 875
Query: 703 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 762
+PG+P NG++ + + ++ F C G+ L + + C H QW P C
Sbjct: 876 DPGIPVNGHR--HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNH--QWNHALPSCDALC 931
Query: 763 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS 822
+ + V P N I + G GV + + F
Sbjct: 932 GGYIQGKSGTVLSPGFPDFYPNSLNCTWTI------EVSHGKGVQMIF------HTFHLE 979
Query: 823 GSHSYSPITVESDFSNPL 840
SH Y IT + FS P+
Sbjct: 980 SSHDYLLITEDGSFSEPV 997
Score = 97.4 bits (241), Expect = 5e-20
Identities = 137/572 (23%), Positives = 200/572 (34%), Gaps = 112/572 (19%)
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
+CGG + G I SP C W+I E R+ L F +L+ED D L V
Sbjct: 31 NCGGLVQGPN-GTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVY 89
Query: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 397
G + +P ++S L + ++ + +E C P
Sbjct: 90 DGQPQQGNLKVRLSGFQLPS-SIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNP 148
Query: 398 F-----LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE-PHWNDTEP 451
+ HG + G +SCLPGY LE I V P W+ P
Sbjct: 149 GEILKGVLHGT------RFNIGDKIRYSCLPGYILEGHAILTCI--VSPGNGASWDFPAP 200
Query: 452 ACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-D 508
C+A CGG L + + SP +P Y DC W + + I L + EG D
Sbjct: 201 FCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYD 260
Query: 509 MLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH---- 564
L + + PS L + P P ++SS L L F + G F +
Sbjct: 261 FLEISGTEAPSI-WLTGMNLPSP---VISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE 316
Query: 565 -----FKEVPR------------------NDTCPELPPPEWGWRTASHGDLIRGTVLTYQ 601
K +P +D CP+ PE G R S + G + +
Sbjct: 317 LKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRV-GANVQFS 375
Query: 602 CEPGYELLGSDILTCQ----WDLSWSAAPPACQK-------------------------- 631
CE Y L GS +TCQ +WS P C+
Sbjct: 376 CEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDN 435
Query: 632 -----IMTCADPG----------EIANGH--RTASDAGFPVGSHVQYRCLPG-------Y 667
++T DP E+ G+ T DAG + L G
Sbjct: 436 AHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 668 SLEGAAMLTCYSRDT-GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLR 726
S+ L S D+ G+P + + ++ C +PG+P G +T + G++L
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGF--KAVYQEIEKGGCGDPGIPAYGKRT--GSSFLHGDTLT 551
Query: 727 FFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
F C FEL+GE ITC +QW+ P C
Sbjct: 552 FECPAAFELVGERVITCQQN--NQWSGNKPSC 581
Score = 92.0 bits (227), Expect = 2e-18
Identities = 58/184 (31%), Positives = 83/184 (45%), Gaps = 15/184 (8%)
Query: 578 PPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD 637
P P + G R TV+ YQC PG+ L+G+ + C D WS P C I TC
Sbjct: 2684 PDPIVNGHISGDGFSYRDTVV-YQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPI-TCGH 2741
Query: 638 PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALK 697
PG A+G S+ F + V + C GY L+G + C S +WS +P C +
Sbjct: 2742 PGNPAHGFTNGSE--FNLNDVVNFTCNTGYLLQGVSRAQCRSNG----QWSSPLPTC--R 2793
Query: 698 YEPCLNPGVPENGY---QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 754
C +PG EN Q + ++ G S+ + C +GF L+G +TC+ W
Sbjct: 2794 VVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMAN--GLWDRS 2851
Query: 755 PPLC 758
P C
Sbjct: 2852 LPKC 2855
Score = 87.8 bits (216), Expect = 4e-17
Identities = 90/359 (25%), Positives = 143/359 (39%), Gaps = 41/359 (11%)
Query: 400 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CG 458
AHG+ D ++ +L FSC G+ L G P ++ + W+ +P C+A+ CG
Sbjct: 2928 AHGSRLGDD--FKTKSLLRFSCEMGHQLR--GSPERTCLLNGS---WSGLQPVCEAVSCG 2980
Query: 459 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGP 518
+ G+++S D S W + + L R + G P
Sbjct: 2981 NPGTPTNGMIVSSDGILFSSSVIYACWEGY---------KTSGLMTRHCTANGTWTGTAP 3031
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLT----LQFQAPPGPPNPGLGQGFVLHFKEVPRNDT- 573
+++ P + G D T + +Q PG + + K+ N +
Sbjct: 3032 DCTIIS-CGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSK 3090
Query: 574 -------CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAP 626
CP+ PP + G T D G+ ++Y C GY+L S IL+C+ W
Sbjct: 3091 PVCKAVLCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEI 3148
Query: 627 PACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPK 686
P C + C DPG A G S F S V ++C + L G++ C + T
Sbjct: 3149 PQCLPVF-CGDPGIPAEGR--LSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGT---- 3201
Query: 687 WSDRVPKCA-LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 744
WS P C + C +PG P G Q Y+ G ++ F C +G+ + G T TC+
Sbjct: 3202 WSGIQPTCIDPAHNTCPDPGTPHFGIQN-SSRGYEVGSTVFFRCRKGYHIQGSTTRTCL 3259
Score = 82.0 bits (201), Expect = 2e-15
Identities = 127/571 (22%), Positives = 196/571 (34%), Gaps = 125/571 (21%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 277
+SCG P PA+ ++ G + C L G +T +C + W+G P C
Sbjct: 2858 ISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH--WSGALPHCTG 2915
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAA--EGRRLHLHFERVSLDEDNDRLM 335
+ G G +P G +G + + ++ + G +L ER L
Sbjct: 2916 NNPGFC-----GDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCL-------- 2962
Query: 336 VRSGGSPLSPVIYDSDMDD--VPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 393
+ S L PV + P G+I + + L S + +
Sbjct: 2963 LNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGI---LFSSSVIYACWEGYKTSGLMTRH 3019
Query: 394 CFAPFLAHGNVTTTDPEYR------PGALA---------------TFSCLPGYALEPPGP 432
C A+G T T P+ PG LA ++ C PGY +E
Sbjct: 3020 C----TANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTS 3075
Query: 433 PNAIECVDPTEPHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQE 491
I C + WN ++P CKA +C G V D+ S C+ G +
Sbjct: 3076 AT-IRCTK--DGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSH 3132
Query: 492 EKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPG 551
+L E V +G++ P F PG
Sbjct: 3133 SA--ILSCEGRGVWKGEI------------------------------PQCLPVFCGDPG 3160
Query: 552 PPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGS 611
P G G +K + + +QC+ + L+GS
Sbjct: 3161 IPAEGRLSGKSFTYK-----------------------------SEVFFQCKSPFILVGS 3191
Query: 612 DILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSL 669
CQ D +WS P C TC DPG G + +S G+ VGS V +RC GY +
Sbjct: 3192 SRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSS-RGYEVGSTVFFRCRKGYHI 3250
Query: 670 EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 729
+G+ TC + T + ++ +P + E + V T G +L + C
Sbjct: 3251 QGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTF-------GYTLVYTC 3303
Query: 730 YEGFELI-GEVTITCVPGHPSQWTSQPPLCK 759
+ GF L G TC +WT + P+CK
Sbjct: 3304 HPGFFLAGGSEHRTCKA--DMKWTGKSPVCK 3332
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/168 (31%), Positives = 72/168 (42%), Gaps = 13/168 (7%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAG 652
G V+ Y C L+G+D CQ D WS A P C C DPG A+G R D
Sbjct: 2879 GAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDD-- 2936
Query: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712
F S +++ C G+ L G+ TC + WS P C + C NPG P NG
Sbjct: 2937 FKTKSLLRFSCEMGHQLRGSPERTCLLNGS----WSGLQPVC--EAVSCGNPGTPTNG-M 2989
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 760
+ S+ + C+EG++ G +T C WT P C +
Sbjct: 2990 IVSSDGILFSSSVIYACWEGYKTSGLMTRHCTAN--GTWTGTAPDCTI 3035
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/166 (30%), Positives = 69/166 (41%), Gaps = 12/166 (7%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
G + Y C+ G+ LLGS LTC + W + P C I +C PG AN T F
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAI-SCGHPGVPANAVLTGE--LFT 2877
Query: 655 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLNPGVPENGYQT 713
G+ V Y C SL G C WS +P C C +PG P +G +
Sbjct: 2878 YGAVVHYSCRGSESLIGNDTRVCQE----DSHWSGALPHCTGNNPGFCGDPGTPAHG--S 2931
Query: 714 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
++ LRF C G +L G TC+ W+ P+C+
Sbjct: 2932 RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLN--GSWSGLQPVCE 2975
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/143 (30%), Positives = 58/143 (40%), Gaps = 19/143 (13%)
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
C DPG A R G VG + + C GY LEGA LTC G WS +P+C
Sbjct: 1046 CDDPGVPAFSRRIGFHFG--VGDSLTFSCFLGYRLEGATKLTCLG--GGRRVWSAPLPRC 1101
Query: 695 ALK--------YEPCLNPGVP---ENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 743
+ L+P P +N ++ +YK +AG+ + F+L T+
Sbjct: 1102 VAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRT-RSFQLFEGDTLKV 1160
Query: 744 VPGHPSQWTSQPPLCKVAYEELL 766
G S S PL ELL
Sbjct: 1161 YDGKDS---SSRPLGTFTKNELL 1180
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-M 276
++CG P PAHG + ++ + F C++GY LQG C + + W+ P+C +
Sbjct: 2737 ITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQ--WSSPLPTCRV 2794
Query: 277 ASCG--GTIHNA 286
+C G + NA
Sbjct: 2795 VNCSDPGFVENA 2806
Score = 33.9 bits (76), Expect = 0.66
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 7/54 (12%)
Query: 239 GGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA-SCG--GTIHNATL 288
G + +HC G+ L G L C+ NG W+ P C+A SCG G NA L
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGL---WDRSLPKCLAISCGHPGVPANAVL 2871
Score = 33.9 bits (76), Expect = 0.66
Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQG--EETLICLNGTRPSWNGETPS 274
++SCG P A+G TD T ++ C+ GY ++ T+ C R WN P
Sbjct: 3035 IISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGR--WNPSKPV 3092
Query: 275 CMA 277
C A
Sbjct: 3093 CKA 3095
Score = 33.1 bits (74), Expect = 1.1
Identities = 32/118 (27%), Positives = 45/118 (38%), Gaps = 9/118 (7%)
Query: 166 GSPGL-APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 219
G PG+ A L+ S + +V + +L S RV + G Q + +
Sbjct: 3157 GDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNT 3216
Query: 220 CGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
C P P G S G T F C GY +QG T CL +W+G C+
Sbjct: 3217 CPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCL--ANLTWSGIQTECI 3272
Score = 32.3 bits (72), Expect = 1.9
Identities = 17/57 (29%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 786 GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYE 842
G++A AIL+P +I+ G Y+Y + + K + H S ++ F NP+Y+
Sbjct: 3487 GSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENS--NGQASFENPMYD 3541
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 224 bits (570), Expect = 3e-58
Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C +S+ G + SP +L DCT++I++ G+G+ +Q + + L +
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2127
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 222
G S ++ S L S T+ L+F S GF I YQAY L
Sbjct: 2128 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185
Query: 223 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 281
PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG
Sbjct: 2186 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2245
Query: 282 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 341
I A G I SP C W++ G ++++F + + D + V G
Sbjct: 2246 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2304
Query: 342 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 400
SP I + E + S + + ++ S+ + + L + A++ C P +
Sbjct: 2305 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2362
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 458
+ + T D E+ G + + CLPG+ L NAI C + P C+ +C
Sbjct: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2418
Query: 459 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 516
EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG
Sbjct: 2419 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2478
Query: 517 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575
+ VL L G + S+G ++ LQ+ A G G ++ + P +
Sbjct: 2479 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2534
Query: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 631
PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ
Sbjct: 2535 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2589
Query: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
I +C P NG +D + VG+ V Y C GY L + T + GT ++
Sbjct: 2590 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2646
Query: 692 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 750
P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P
Sbjct: 2647 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2706
Query: 751 WTSQPPLCKV 760
W ++ P C++
Sbjct: 2707 WRNERPYCQI 2716
Score = 208 bits (529), Expect = 2e-53
Identities = 189/718 (26%), Positives = 286/718 (39%), Gaps = 79/718 (11%)
Query: 98 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 157
T V C +++ +G + SP P L +C + I V G GI++QV +
Sbjct: 1894 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1950
Query: 158 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
+ L GG APRL + S +L S +N L L+FQS GF + Y A
Sbjct: 1951 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008
Query: 218 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C
Sbjct: 2009 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
+A CGG + + + G I+SP G +L C W I G +HL F S + +D L
Sbjct: 2068 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126
Query: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395
VRSG S S VI +P L S + S+ N + ++A++ C
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185
Query: 396 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
P +G V D + G +F C PGY L +A+ C+ +WN P C+
Sbjct: 2186 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2240
Query: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 513
A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++
Sbjct: 2241 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300
Query: 514 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 573
DG ++ + Q G + S+ + ++F + GF + +
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2354
Query: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 630
C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414
Query: 631 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 655
+ CA + G+ ++ F V
Sbjct: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474
Query: 656 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 703
G ++Q Y + G + +S D G K R+ A C
Sbjct: 2475 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2531
Query: 704 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 759
P P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2532 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588
Score = 207 bits (528), Expect = 3e-53
Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + S G + SP +L +C + I PG+ I+I + ++L +
Sbjct: 855 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 911
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 219
G P L LL + + Q L S +N + L F + GF+IHY++ + S
Sbjct: 912 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279
C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C
Sbjct: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1027
Query: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339
GG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 1028 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086
Query: 340 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 397
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P
Sbjct: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1145
Query: 398 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 457
+ + + G TFSC GY LE + I C+ W+ P C A C
Sbjct: 1146 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1201
Query: 458 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 517
G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261
Query: 518 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 576
+ +L G R LSS L L+F + G +GF L + + C +
Sbjct: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1316
Query: 577 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 634
P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1317 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1373
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 682
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1374 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1432
Query: 683 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 705
P +D + K A+++ C +PG
Sbjct: 1433 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1492
Query: 706 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 758
VP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1493 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Score = 206 bits (524), Expect = 7e-53
Identities = 190/786 (24%), Positives = 317/786 (40%), Gaps = 93/786 (11%)
Query: 109 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 168
E G + SP P L C + I V PG + +Q + ++L + G
Sbjct: 1381 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1437
Query: 169 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 227
+ S++ EG + S N + + F + GF I + + + + C P P
Sbjct: 1438 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495
Query: 228 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 286
+G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + +
Sbjct: 1496 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1555
Query: 287 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 346
+ G I+SP + C W I + L F S++ + D L + G SP+
Sbjct: 1556 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1614
Query: 347 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 404
I +PER + S + ++++ S+ + L ++A + CF P GN+
Sbjct: 1615 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1669
Query: 405 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 461
T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG
Sbjct: 1670 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1726
Query: 462 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 521
+ G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG +
Sbjct: 1727 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1786
Query: 522 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 578
+L+ L G L LSSG +T++F + P +GF ++ VPR + C +P
Sbjct: 1787 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1842
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 630
P +G R + + G+ + + C PGY L GS + C QW+ S C
Sbjct: 1843 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900
Query: 631 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 670
I+T ++ G+ D P G+ +Q + + ++ E
Sbjct: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1959
Query: 671 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
A L YS D + A+ + C P P
Sbjct: 1960 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2019
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDN 768
+G + Y G+ + F C +G+ L G ITC+PG +W P+C + +
Sbjct: 2020 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSD 2077
Query: 769 RKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGS 824
+ P + I LP+G GV++ + +++ + SGS
Sbjct: 2078 FSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNFSTETIHDYLEVRSGS 2131
Query: 825 HSYSPI 830
S +
Sbjct: 2132 SETSTV 2137
Score = 182 bits (463), Expect = 9e-46
Identities = 154/570 (27%), Positives = 238/570 (41%), Gaps = 29/570 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + + EG + SP+ +C YSI V G GI I +T +L+Q + L +
Sbjct: 1201 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1257
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221
G +SM G L S +N+L L F S GF++ Y ++ LS C
Sbjct: 1258 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1315
Query: 222 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG
Sbjct: 1316 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1375
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
G + GRI+SP NL C W+IE G + L F + +D L V G
Sbjct: 1376 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
++ + +PE G+ S + ++ ++ + +++F + C P +
Sbjct: 1436 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1494
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 459
N T PG F C PGY L+ I C+ + W + P C A CGG
Sbjct: 1495 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1550
Query: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518
L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG
Sbjct: 1551 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1610
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578
++ ++ + + R+ SS + L F++ GF L +K R ++C
Sbjct: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1663
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 634
P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH--AP 1721
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL 664
C + G T +P V + C+
Sbjct: 1722 CGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1749
Score = 170 bits (431), Expect = 5e-42
Identities = 192/786 (24%), Positives = 300/786 (38%), Gaps = 104/786 (13%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N++ G++ SP+ P + DC ++I V Y I + + ++ + L +
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 216
G +NS ++G Q + P +N + L F+S GF + Y+A
Sbjct: 1605 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656
Query: 217 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 273
L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P
Sbjct: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 274 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 331
SC A CG + G ++SP +VG N + F + SL +
Sbjct: 1717 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1772
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 389
D + V G + S ++ E +S + + S P ++A
Sbjct: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832
Query: 390 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 445
+C + P G E+ G+ F C PGY L AI C V +
Sbjct: 1833 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1887
Query: 446 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 504
WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1888 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1947
Query: 505 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 564
D L +DG +A L G L S+ +L L FQ+ GF L
Sbjct: 1948 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2003
Query: 565 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 622
+ + D+CPE P G + + G V+++QC+ GY L G +TC W
Sbjct: 2004 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060
Query: 623 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 668
+ P C I++ PG + P+G H+Q+ +
Sbjct: 2061 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2120
Query: 669 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 697
+ + S +T T K + A +
Sbjct: 2121 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2180
Query: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757
+ C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P
Sbjct: 2181 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238
Query: 758 CKVAYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQG 815
C E L + T P E N L + + G+G+YI +T LQ
Sbjct: 2239 C-----EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQT 2290
Query: 816 KSLFGF 821
+ ++ F
Sbjct: 2291 EPIYDF 2296
Score = 167 bits (422), Expect = 5e-41
Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 161
C +N+ G SP+ C + I V I+I + +L + L
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564
Query: 162 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 220
+ GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC
Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624
Query: 221 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
G P P +G F C G++L GE++++C + W+ P C+ C
Sbjct: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G
Sbjct: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
SP SP++ +VP L S++ L +E ++ + ++ + F + C P +
Sbjct: 742 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 800
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 460
N ++ G+ + C G+ ++ G + + W+ P C A CGG
Sbjct: 801 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 858
Query: 461 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 519
S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 859 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 918
Query: 520 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 578
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 919 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 974
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 638
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 975 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1028
Query: 639 GEIANGHRTASDAGFP 654
G++ T G+P
Sbjct: 1029 GDVRGPSGTILSPGYP 1044
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 276
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 335
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564
Query: 336 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 390
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620
Query: 391 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674
Query: 451 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 509
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734
Query: 510 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 569
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790
Query: 570 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 625
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847
Query: 626 PPAC 629
P C
Sbjct: 848 IPKC 851
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%)
Query: 591 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 648
D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG
Sbjct: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3206
Query: 649 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P
Sbjct: 3207 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3258
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
G + YQ+ + F C F L+G T C W+ P C
Sbjct: 3259 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3304
Score = 88.2 bits (217), Expect = 3e-17
Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K
Sbjct: 3015 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 3071
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
+ C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P
Sbjct: 3072 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 3126
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 750
C + C +PG+P NG + Y Y G+++ + C G+ EL G TC
Sbjct: 3127 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3180
Query: 751 WTSQPPLCK 759
W+ P C+
Sbjct: 3181 WSGVMPTCR 3189
Score = 84.0 bits (206), Expect = 6e-16
Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 571 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951
Query: 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004
Query: 691 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 749
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060
Query: 750 QWTSQPPLCK 759
WT + P CK
Sbjct: 3061 SWTGRQPECK 3070
Score = 83.2 bits (204), Expect = 9e-16
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302
Query: 693 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359
Query: 752 TSQPPLC 758
+ P C
Sbjct: 3360 SGIQPEC 3366
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 653
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851
Query: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 713
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905
Query: 714 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
H + G + + C G+ L G + C P QW P C
Sbjct: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950
Score = 69.7 bits (169), Expect = 1e-11
Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + G +ESP G P G +CT+ I I+I Q+ L +E + L L
Sbjct: 25 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221
G R L + S + L S GF+++Y+ S CG
Sbjct: 82 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139
Query: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 277
P P G + T G + C +GY L G L C+ + SW+ P C A
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
+CGGT+ ++ G I SP N C W I A G + L F ++E D L +
Sbjct: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257
Query: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 375
G P P I+ S M+ P +IS+ L + ++++
Sbjct: 258 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291
Score = 68.2 bits (165), Expect = 3e-11
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%)
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
+CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L +
Sbjct: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82
Query: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 396
G P + + + ++ +S++ + L S+ + + +E + C
Sbjct: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140
Query: 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 454
P + V + G +SC+ GY L+ G P + C+ W+ P C+
Sbjct: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196
Query: 455 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 512
A CGG + +G++ SP +P Y DC W + + I L + E
Sbjct: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256
Query: 513 FDGDGPSARVLAQLRGPQP 531
+G P L+ + P P
Sbjct: 257 IEGSEPPTIWLSGMNIPPP 275
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC-LA 2774
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2775 GHCGIPELIVNGQVIGENYGY--RDTVVYQCNPGFRLIGSSVRICQQ----DHNWSGQLP 2828
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 752
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2829 SCV--PVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882
Query: 753 SQPPLCKV 760
PP+CKV
Sbjct: 2883 HPPPMCKV 2890
Score = 57.4 bits (137), Expect = 6e-08
Identities = 95/374 (25%), Positives = 147/374 (39%), Gaps = 72/374 (19%)
Query: 101 VLC--NNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE 158
VLC N + G + SP G P S L C +SI V GY I + V+ +E +
Sbjct: 2414 VLCPANELRLDSTGVILSP--GYPDSYP-NLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470
Query: 159 LLVLAGGGSPGL-APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
+L + G P + +P L++ S + S + + L + + GFRI Y A+
Sbjct: 2471 VLQVYDG--PNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY 2528
Query: 218 LSCGFPPRPAHGDV-SVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP--SWNGETPS 274
C P P HG + S T + CD G++L G+ + +C + +W+ P+
Sbjct: 2529 --CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2586
Query: 275 CMA-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 333
C A SC G +P GG LT +++ G R+ D R
Sbjct: 2587 CQAISC---------GIPKAPTNGGI----LTTDYLV----GTRV------TYFCNDGYR 2623
Query: 334 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 393
L + L+ + SD G S+ ++TP ++ +F
Sbjct: 2624 LSSKE----LTTAVCQSD-------GTWSNH--------NKTPRCVVVTCPSINSF---- 2660
Query: 394 CFAPFLAHGN---VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450
L HG V + EY+ + FSC PGY P +IEC+ W +
Sbjct: 2661 ----ILEHGRWRIVNGSHYEYKTKVV--FSCDPGYHGLGPA---SIECLPNGTWSWRNER 2711
Query: 451 PACKAMCGGELSEP 464
P C+ + GEL P
Sbjct: 2712 PYCQIISCGELPTP 2725
Score = 57.0 bits (136), Expect = 7e-08
Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%)
Query: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 515
CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84
Query: 516 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575
+L G + S+ +L+ + GF ++++E+ ++ +C
Sbjct: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139
Query: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 631
P G + D+ G + Y C GY L G LTC + SW P C+
Sbjct: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197
Query: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 663
C G + S FP H C
Sbjct: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227
Score = 53.5 bits (127), Expect = 8e-07
Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 166 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 219
G PG+ P + + G + S T + L QS R + G Q + +
Sbjct: 2956 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3015
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 277
CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 3016 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3072
Query: 278 SCG--GTIHNATLGRI 291
CG GT N + RI
Sbjct: 3073 QCGNPGTTANGKVFRI 3088
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C
Sbjct: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 695 ALK 697
+K
Sbjct: 504 KVK 506
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 569 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 628
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365
Query: 629 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 684
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418
Query: 685 PKWSDRVPKC 694
W+ +VP C
Sbjct: 3419 --WTGKVPIC 3426
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 753
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190
Query: 754 QPPLCK 759
P+C+
Sbjct: 191 PVPICR 196
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693
+C +PG G F VG ++Y C+ GY L+G LTC + T W VP
Sbjct: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194
Query: 694 C 694
C
Sbjct: 195 C 195
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 699 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 756
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 757 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 807
C + V P G N +I +P V+ L V
Sbjct: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776
Query: 808 IYYTKLQGKSLF-GFSGSHSYSPITVES 834
+Y Q SL SGSHS + + S
Sbjct: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276
++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+
Sbjct: 3191 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3247
Query: 277 AS-CG 280
CG
Sbjct: 3248 PKFCG 3252
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 755
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674
Query: 756 PLC 758
P+C
Sbjct: 675 PIC 677
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773
Query: 277 ASCGGTIHNATLGRIVSPEPG 297
A G G+++ G
Sbjct: 2774 AGHCGIPELIVNGQVIGENYG 2794
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 219 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367
Score = 38.5 bits (88), Expect = 0.027
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 758
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 759 KV 760
KV
Sbjct: 504 KV 505
Score = 38.5 bits (88), Expect = 0.027
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 278
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNWSGQLPSCVPVS 2834
Query: 279 CG 280
CG
Sbjct: 2835 CG 2836
Score = 38.5 bits (88), Expect = 0.027
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 273
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186
Query: 274 SCMASCGGTIHNATLGRI 291
+C A T + GR+
Sbjct: 3187 TCRAVTCPTPPQISNGRL 3204
Score = 35.8 bits (81), Expect = 0.17
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888
Score = 35.0 bits (79), Expect = 0.30
Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Query: 214 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 272
+ ++ CG P P + +S G T + C L G+ + C LNG W+G
Sbjct: 2949 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3005
Query: 273 PSCMASCGGT 282
P C GT
Sbjct: 3006 PHCSGDATGT 3015
Score = 34.3 bits (77), Expect = 0.50
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 219 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 276
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427
Query: 277 A 277
A
Sbjct: 3428 A 3428
Score = 34.3 bits (77), Expect = 0.50
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 771 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 827
L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3571 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3628
Query: 828 SPITVESDFSNPLYE 842
++ F NP+Y+
Sbjct: 3629 ENNNGQAAFENPMYD 3643
Score = 31.6 bits (70), Expect = 3.3
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 586 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 630
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3376 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3427
Score = 31.2 bits (69), Expect = 4.3
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 271
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2890 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2946
Query: 272 TPSC-MASCG--GTIHNATL 288
P C M CG G NA L
Sbjct: 2947 LPECIMIDCGHPGVPPNAVL 2966
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 224 bits (570), Expect = 3e-58
Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C +S+ G + SP +L DCT++I++ G+G+ +Q + + L +
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2167
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 222
G S ++ S L S T+ L+F S GF I YQAY L
Sbjct: 2168 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2225
Query: 223 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 281
PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG
Sbjct: 2226 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2285
Query: 282 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 341
I A G I SP C W++ G ++++F + + D + V G
Sbjct: 2286 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2344
Query: 342 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 400
SP I + E + S + + ++ S+ + + L + A++ C P +
Sbjct: 2345 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2402
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 458
+ + T D E+ G + + CLPG+ L NAI C + P C+ +C
Sbjct: 2403 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2458
Query: 459 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 516
EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG
Sbjct: 2459 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2518
Query: 517 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575
+ VL L G + S+G ++ LQ+ A G G ++ + P +
Sbjct: 2519 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2574
Query: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 631
PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ
Sbjct: 2575 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2629
Query: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
I +C P NG +D + VG+ V Y C GY L + T + GT ++
Sbjct: 2630 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2686
Query: 692 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 750
P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P
Sbjct: 2687 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2746
Query: 751 WTSQPPLCKV 760
W ++ P C++
Sbjct: 2747 WRNERPYCQI 2756
Score = 208 bits (529), Expect = 2e-53
Identities = 189/718 (26%), Positives = 286/718 (39%), Gaps = 79/718 (11%)
Query: 98 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 157
T V C +++ +G + SP P L +C + I V G GI++QV +
Sbjct: 1934 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1990
Query: 158 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
+ L GG APRL + S +L S +N L L+FQS GF + Y A
Sbjct: 1991 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2048
Query: 218 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C
Sbjct: 2049 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
+A CGG + + + G I+SP G +L C W I G +HL F S + +D L
Sbjct: 2108 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2166
Query: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395
VRSG S S VI +P L S + S+ N + ++A++ C
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2225
Query: 396 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
P +G V D + G +F C PGY L +A+ C+ +WN P C+
Sbjct: 2226 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2280
Query: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 513
A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++
Sbjct: 2281 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2340
Query: 514 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 573
DG ++ + Q G + S+ + ++F + GF + +
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2394
Query: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 630
C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2454
Query: 631 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 655
+ CA + G+ ++ F V
Sbjct: 2455 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2514
Query: 656 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 703
G ++Q Y + G + +S D G K R+ A C
Sbjct: 2515 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2571
Query: 704 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 759
P P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2572 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628
Score = 207 bits (528), Expect = 3e-53
Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + S G + SP +L +C + I PG+ I+I + ++L +
Sbjct: 895 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 951
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 219
G P L LL + + Q L S +N + L F + GF+IHY++ + S
Sbjct: 952 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 1009
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279
C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C
Sbjct: 1010 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1067
Query: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339
GG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 1068 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1126
Query: 340 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 397
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P
Sbjct: 1127 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1185
Query: 398 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 457
+ + + G TFSC GY LE + I C+ W+ P C A C
Sbjct: 1186 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1241
Query: 458 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 517
G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1242 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1301
Query: 518 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 576
+ +L G R LSS L L+F + G +GF L + + C +
Sbjct: 1302 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1356
Query: 577 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 634
P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1357 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1413
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 682
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1414 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1472
Query: 683 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 705
P +D + K A+++ C +PG
Sbjct: 1473 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1532
Query: 706 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 758
VP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1533 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Score = 206 bits (524), Expect = 7e-53
Identities = 190/786 (24%), Positives = 317/786 (40%), Gaps = 93/786 (11%)
Query: 109 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 168
E G + SP P L C + I V PG + +Q + ++L + G
Sbjct: 1421 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1477
Query: 169 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 227
+ S++ EG + S N + + F + GF I + + + + C P P
Sbjct: 1478 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1535
Query: 228 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 286
+G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + +
Sbjct: 1536 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1595
Query: 287 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 346
+ G I+SP + C W I + L F S++ + D L + G SP+
Sbjct: 1596 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1654
Query: 347 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 404
I +PER + S + ++++ S+ + L ++A + CF P GN+
Sbjct: 1655 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1709
Query: 405 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 461
T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG
Sbjct: 1710 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1766
Query: 462 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 521
+ G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG +
Sbjct: 1767 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1826
Query: 522 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 578
+L+ L G L LSSG +T++F + P +GF ++ VPR + C +P
Sbjct: 1827 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1882
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 630
P +G R + + G+ + + C PGY L GS + C QW+ S C
Sbjct: 1883 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1940
Query: 631 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 670
I+T ++ G+ D P G+ +Q + + ++ E
Sbjct: 1941 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1999
Query: 671 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
A L YS D + A+ + C P P
Sbjct: 2000 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2059
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDN 768
+G + Y G+ + F C +G+ L G ITC+PG +W P+C + +
Sbjct: 2060 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSD 2117
Query: 769 RKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGS 824
+ P + I LP+G GV++ + +++ + SGS
Sbjct: 2118 FSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNFSTETIHDYLEVRSGS 2171
Query: 825 HSYSPI 830
S +
Sbjct: 2172 SETSTV 2177
Score = 182 bits (463), Expect = 9e-46
Identities = 154/570 (27%), Positives = 238/570 (41%), Gaps = 29/570 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + + EG + SP+ +C YSI V G GI I +T +L+Q + L +
Sbjct: 1241 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1297
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221
G +SM G L S +N+L L F S GF++ Y ++ LS C
Sbjct: 1298 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1355
Query: 222 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG
Sbjct: 1356 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1415
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
G + GRI+SP NL C W+IE G + L F + +D L V G
Sbjct: 1416 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1475
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
++ + +PE G+ S + ++ ++ + +++F + C P +
Sbjct: 1476 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1534
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 459
N T PG F C PGY L+ I C+ + W + P C A CGG
Sbjct: 1535 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1590
Query: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518
L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG
Sbjct: 1591 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1650
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578
++ ++ + + R+ SS + L F++ GF L +K R ++C
Sbjct: 1651 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1703
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 634
P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1704 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH--AP 1761
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL 664
C + G T +P V + C+
Sbjct: 1762 CGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1789
Score = 170 bits (431), Expect = 5e-42
Identities = 192/786 (24%), Positives = 300/786 (38%), Gaps = 104/786 (13%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N++ G++ SP+ P + DC ++I V Y I + + ++ + L +
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1644
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 216
G +NS ++G Q + P +N + L F+S GF + Y+A
Sbjct: 1645 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1696
Query: 217 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 273
L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P
Sbjct: 1697 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 274 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 331
SC A CG + G ++SP +VG N + F + SL +
Sbjct: 1757 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1812
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 389
D + V G + S ++ E +S + + S P ++A
Sbjct: 1813 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1872
Query: 390 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 445
+C + P G E+ G+ F C PGY L AI C V +
Sbjct: 1873 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1927
Query: 446 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 504
WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1928 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1987
Query: 505 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 564
D L +DG +A L G L S+ +L L FQ+ GF L
Sbjct: 1988 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2043
Query: 565 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 622
+ + D+CPE P G + + G V+++QC+ GY L G +TC W
Sbjct: 2044 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2100
Query: 623 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 668
+ P C I++ PG + P+G H+Q+ +
Sbjct: 2101 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2160
Query: 669 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 697
+ + S +T T K + A +
Sbjct: 2161 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2220
Query: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757
+ C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P
Sbjct: 2221 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2278
Query: 758 CKVAYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQG 815
C E L + T P E N L + + G+G+YI +T LQ
Sbjct: 2279 C-----EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQT 2330
Query: 816 KSLFGF 821
+ ++ F
Sbjct: 2331 EPIYDF 2336
Score = 167 bits (422), Expect = 5e-41
Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 161
C +N+ G SP+ C + I V I+I + +L + L
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604
Query: 162 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 220
+ GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC
Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 664
Query: 221 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
G P P +G F C G++L GE++++C + W+ P C+ C
Sbjct: 665 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 722
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G
Sbjct: 723 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 781
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
SP SP++ +VP L S++ L +E ++ + ++ + F + C P +
Sbjct: 782 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 840
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 460
N ++ G+ + C G+ ++ G + + W+ P C A CGG
Sbjct: 841 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 898
Query: 461 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 519
S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 899 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 958
Query: 520 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 578
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 959 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 1014
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 638
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 1015 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1068
Query: 639 GEIANGHRTASDAGFP 654
G++ T G+P
Sbjct: 1069 GDVRGPSGTILSPGYP 1084
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 276
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 486 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 335
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 546 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604
Query: 336 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 390
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 660
Query: 391 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 661 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 714
Query: 451 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 509
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 715 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 774
Query: 510 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 569
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 775 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 830
Query: 570 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 625
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 831 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 887
Query: 626 PPAC 629
P C
Sbjct: 888 IPKC 891
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%)
Query: 591 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 648
D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG
Sbjct: 3188 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3246
Query: 649 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P
Sbjct: 3247 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3298
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
G + YQ+ + F C F L+G T C W+ P C
Sbjct: 3299 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3344
Score = 88.2 bits (217), Expect = 3e-17
Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K
Sbjct: 3055 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 3111
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
+ C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P
Sbjct: 3112 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 3166
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 750
C + C +PG+P NG + Y Y G+++ + C G+ EL G TC
Sbjct: 3167 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3220
Query: 751 WTSQPPLCK 759
W+ P C+
Sbjct: 3221 WSGVMPTCR 3229
Score = 84.0 bits (206), Expect = 6e-16
Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 571 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2932 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2991
Query: 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2992 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3044
Query: 691 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 749
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 3045 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3100
Query: 750 QWTSQPPLCK 759
WT + P CK
Sbjct: 3101 SWTGRQPECK 3110
Score = 83.2 bits (204), Expect = 9e-16
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3232 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3288
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3289 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3342
Query: 693 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3343 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3399
Query: 752 TSQPPLC 758
+ P C
Sbjct: 3400 SGIQPEC 3406
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 653
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2836 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2891
Query: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 713
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2892 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2945
Query: 714 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
H + G + + C G+ L G + C P QW P C
Sbjct: 2946 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2990
Score = 69.7 bits (169), Expect = 1e-11
Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + G +ESP G P G +CT+ I I+I Q+ L +E + L L
Sbjct: 65 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 121
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221
G R L + S + L S GF+++Y+ S CG
Sbjct: 122 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 277
P P G + T G + C +GY L G L C+ + SW+ P C A
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
+CGGT+ ++ G I SP N C W I A G + L F ++E D L +
Sbjct: 240 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 297
Query: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 375
G P P I+ S M+ P +IS+ L + ++++
Sbjct: 298 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 331
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/269 (23%), Positives = 108/269 (40%), Gaps = 16/269 (5%)
Query: 272 TPSCMA----SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 327
T SC+ +CGGT+ G I SP C WVI A E R+ + F+ +L
Sbjct: 54 TVSCVKGFIYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFAL 112
Query: 328 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRF 386
+E+ D L + G P + + + ++ +S++ + L S+ + + +
Sbjct: 113 EEEYDYLSLYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 387 EAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEP 444
E + C P + V + G +SC+ GY L+ G P + C+
Sbjct: 171 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTA 226
Query: 445 HWNDTEPACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 502
W+ P C+A CGG + +G++ SP +P Y DC W + + I L
Sbjct: 227 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 286
Query: 503 NVREGDMLTLFDGDGPSARVLAQLRGPQP 531
+ E +G P L+ + P P
Sbjct: 287 QMEEKYDYLEIEGSEPPTIWLSGMNIPPP 315
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2758 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC-LA 2814
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2815 GHCGIPELIVNGQVIGENYGY--RDTVVYQCNPGFRLIGSSVRICQQ----DHNWSGQLP 2868
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 752
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2869 SCV--PVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2922
Query: 753 SQPPLCKV 760
PP+CKV
Sbjct: 2923 HPPPMCKV 2930
Score = 57.4 bits (137), Expect = 6e-08
Identities = 95/374 (25%), Positives = 147/374 (39%), Gaps = 72/374 (19%)
Query: 101 VLC--NNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE 158
VLC N + G + SP G P S L C +SI V GY I + V+ +E +
Sbjct: 2454 VLCPANELRLDSTGVILSP--GYPDSYP-NLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2510
Query: 159 LLVLAGGGSPGL-APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
+L + G P + +P L++ S + S + + L + + GFRI Y A+
Sbjct: 2511 VLQVYDG--PNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY 2568
Query: 218 LSCGFPPRPAHGDV-SVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP--SWNGETPS 274
C P P HG + S T + CD G++L G+ + +C + +W+ P+
Sbjct: 2569 --CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2626
Query: 275 CMA-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 333
C A SC G +P GG LT +++ G R+ D R
Sbjct: 2627 CQAISC---------GIPKAPTNGGI----LTTDYLV----GTRV------TYFCNDGYR 2663
Query: 334 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 393
L + L+ + SD G S+ ++TP ++ +F
Sbjct: 2664 LSSKE----LTTAVCQSD-------GTWSNH--------NKTPRCVVVTCPSINSF---- 2700
Query: 394 CFAPFLAHGN---VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450
L HG V + EY+ + FSC PGY P +IEC+ W +
Sbjct: 2701 ----ILEHGRWRIVNGSHYEYKTKVV--FSCDPGYHGLGPA---SIECLPNGTWSWRNER 2751
Query: 451 PACKAMCGGELSEP 464
P C+ + GEL P
Sbjct: 2752 PYCQIISCGELPTP 2765
Score = 57.0 bits (136), Expect = 7e-08
Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%)
Query: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 515
CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 124
Query: 516 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575
+L G + S+ +L+ + GF ++++E+ ++ +C
Sbjct: 125 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 179
Query: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 631
P G + D+ G + Y C GY L G LTC + SW P C+
Sbjct: 180 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Query: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 663
C G + S FP H C
Sbjct: 238 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 267
Score = 53.5 bits (127), Expect = 8e-07
Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 166 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 219
G PG+ P + + G + S T + L QS R + G Q + +
Sbjct: 2996 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3055
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 277
CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 3056 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3112
Query: 278 SCG--GTIHNATLGRI 291
CG GT N + RI
Sbjct: 3113 QCGNPGTTANGKVFRI 3128
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C
Sbjct: 486 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 695 ALK 697
+K
Sbjct: 544 KVK 546
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 569 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 628
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3347 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3405
Query: 629 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 684
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3406 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3458
Query: 685 PKWSDRVPKC 694
W+ +VP C
Sbjct: 3459 --WTGKVPIC 3466
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 753
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 173 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 754 QPPLCK 759
P+C+
Sbjct: 231 PVPICR 236
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693
+C +PG G F VG ++Y C+ GY L+G LTC + T W VP
Sbjct: 177 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 694 C 694
C
Sbjct: 235 C 235
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 699 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 756
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1699 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 757 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 807
C + V P G N +I +P V+ L V
Sbjct: 1757 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1816
Query: 808 IYYTKLQGKSLF-GFSGSHSYSPITVES 834
+Y Q SL SGSHS + + S
Sbjct: 1817 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1844
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276
++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+
Sbjct: 3231 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3287
Query: 277 AS-CG 280
CG
Sbjct: 3288 PKFCG 3292
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 755
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 659 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 714
Query: 756 PLC 758
P+C
Sbjct: 715 PIC 717
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2756 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2813
Query: 277 ASCGGTIHNATLGRIVSPEPG 297
A G G+++ G
Sbjct: 2814 AGHCGIPELIVNGQVIGENYG 2834
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 219 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3351 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3407
Score = 38.5 bits (88), Expect = 0.027
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 758
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 486 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 759 KV 760
KV
Sbjct: 544 KV 545
Score = 38.5 bits (88), Expect = 0.027
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 278
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2817 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNWSGQLPSCVPVS 2874
Query: 279 CG 280
CG
Sbjct: 2875 CG 2876
Score = 38.5 bits (88), Expect = 0.027
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 273
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3170 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3226
Query: 274 SCMASCGGTIHNATLGRI 291
+C A T + GR+
Sbjct: 3227 TCRAVTCPTPPQISNGRL 3244
Score = 35.8 bits (81), Expect = 0.17
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2873 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2928
Score = 35.0 bits (79), Expect = 0.30
Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Query: 214 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 272
+ ++ CG P P + +S G T + C L G+ + C LNG W+G
Sbjct: 2989 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3045
Query: 273 PSCMASCGGT 282
P C GT
Sbjct: 3046 PHCSGDATGT 3055
Score = 34.3 bits (77), Expect = 0.50
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 219 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 276
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3410 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3467
Query: 277 A 277
A
Sbjct: 3468 A 3468
Score = 34.3 bits (77), Expect = 0.50
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 771 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 827
L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3611 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3668
Query: 828 SPITVESDFSNPLYE 842
++ F NP+Y+
Sbjct: 3669 ENNNGQAAFENPMYD 3683
Score = 31.6 bits (70), Expect = 3.3
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 586 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 630
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3416 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3467
Score = 31.2 bits (69), Expect = 4.3
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 271
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2930 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2986
Query: 272 TPSC-MASCG--GTIHNATL 288
P C M CG G NA L
Sbjct: 2987 LPECIMIDCGHPGVPPNAVL 3006
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 208 bits (529), Expect = 2e-53
Identities = 189/718 (26%), Positives = 286/718 (39%), Gaps = 79/718 (11%)
Query: 98 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 157
T V C +++ +G + SP P L +C + I V G GI++QV +
Sbjct: 1830 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1886
Query: 158 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
+ L GG APRL + S +L S +N L L+FQS GF + Y A
Sbjct: 1887 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 1944
Query: 218 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C
Sbjct: 1945 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 335
+A CGG + + + G I+SP G +L C W I G +HL F S + +D L
Sbjct: 2004 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2062
Query: 336 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 395
VRSG S S VI +P L S + S+ N + ++A++ C
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2121
Query: 396 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
P +G V D + G +F C PGY L +A+ C+ +WN P C+
Sbjct: 2122 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2176
Query: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 513
A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++
Sbjct: 2177 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2236
Query: 514 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 573
DG ++ + Q G + S+ + ++F + GF + +
Sbjct: 2237 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2290
Query: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 630
C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2350
Query: 631 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 655
+ CA + G+ ++ F V
Sbjct: 2351 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2410
Query: 656 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 703
G ++Q Y + G + +S D G K R+ A C
Sbjct: 2411 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2467
Query: 704 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 759
P P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2468 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2524
Score = 207 bits (528), Expect = 3e-53
Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + S G + SP +L +C + I PG+ I+I + ++L +
Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 847
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 219
G P L LL + + Q L S +N + L F + GF+IHY++ + S
Sbjct: 848 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 905
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279
C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C
Sbjct: 906 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 963
Query: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339
GG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 964 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1022
Query: 340 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 397
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P
Sbjct: 1023 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1081
Query: 398 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 457
+ + + G TFSC GY LE + I C+ W+ P C A C
Sbjct: 1082 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1137
Query: 458 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 517
G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1138 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1197
Query: 518 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 576
+ +L G R LSS L L+F + G +GF L + + C +
Sbjct: 1198 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1252
Query: 577 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 634
P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1253 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1309
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 682
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1310 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1368
Query: 683 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 705
P +D + K A+++ C +PG
Sbjct: 1369 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1428
Query: 706 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 758
VP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1429 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Score = 206 bits (524), Expect = 7e-53
Identities = 190/786 (24%), Positives = 317/786 (40%), Gaps = 93/786 (11%)
Query: 109 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 168
E G + SP P L C + I V PG + +Q + ++L + G
Sbjct: 1317 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1373
Query: 169 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 227
+ S++ EG + S N + + F + GF I + + + + C P P
Sbjct: 1374 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1431
Query: 228 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 286
+G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + +
Sbjct: 1432 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1491
Query: 287 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 346
+ G I+SP + C W I + L F S++ + D L + G SP+
Sbjct: 1492 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1550
Query: 347 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 404
I +PER + S + ++++ S+ + L ++A + CF P GN+
Sbjct: 1551 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1605
Query: 405 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 461
T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG
Sbjct: 1606 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1662
Query: 462 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 521
+ G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG +
Sbjct: 1663 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1722
Query: 522 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 578
+L+ L G L LSSG +T++F + P +GF ++ VPR + C +P
Sbjct: 1723 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1778
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 630
P +G R + + G+ + + C PGY L GS + C QW+ S C
Sbjct: 1779 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1836
Query: 631 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 670
I+T ++ G+ D P G+ +Q + + ++ E
Sbjct: 1837 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1895
Query: 671 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
A L YS D + A+ + C P P
Sbjct: 1896 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 1955
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDN 768
+G + Y G+ + F C +G+ L G ITC+PG +W P+C + +
Sbjct: 1956 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSD 2013
Query: 769 RKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGS 824
+ P + I LP+G GV++ + +++ + SGS
Sbjct: 2014 FSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNFSTETIHDYLEVRSGS 2067
Query: 825 HSYSPI 830
S +
Sbjct: 2068 SETSTV 2073
Score = 204 bits (519), Expect = 3e-52
Identities = 180/667 (26%), Positives = 280/667 (41%), Gaps = 41/667 (6%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C +S+ G + SP +L DCT++I++ G+G+ +Q + + L +
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2063
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 222
G S ++ S L S T+ L+F S GF I YQAY L
Sbjct: 2064 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2121
Query: 223 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 281
PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG
Sbjct: 2122 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2181
Query: 282 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 341
I A G I SP C W++ G ++++F + + D + V G
Sbjct: 2182 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2240
Query: 342 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 400
SP I + E + S + + ++ S+ + + L + A++ C P +
Sbjct: 2241 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2298
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 458
+ + T D E+ G + + CLPG+ L NAI C + P C+ +C
Sbjct: 2299 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2354
Query: 459 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 516
EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG
Sbjct: 2355 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2414
Query: 517 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 575
+ VL L G + S+G ++ LQ+ A G G ++ + P +
Sbjct: 2415 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2470
Query: 576 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 631
PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ
Sbjct: 2471 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2525
Query: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
I +C P NG +D + VG+ V Y C GY L + T + GT ++
Sbjct: 2526 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2582
Query: 692 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
P+C + C P NG + + Y G + F C GF L+G C+ W
Sbjct: 2583 PRCVV--ISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSS--GLW 2636
Query: 752 TSQPPLC 758
+ C
Sbjct: 2637 SESETRC 2643
Score = 182 bits (463), Expect = 9e-46
Identities = 154/570 (27%), Positives = 238/570 (41%), Gaps = 29/570 (5%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + + EG + SP+ +C YSI V G GI I +T +L+Q + L +
Sbjct: 1137 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1193
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221
G +SM G L S +N+L L F S GF++ Y ++ LS C
Sbjct: 1194 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1251
Query: 222 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG
Sbjct: 1252 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1311
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
G + GRI+SP NL C W+IE G + L F + +D L V G
Sbjct: 1312 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1371
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
++ + +PE G+ S + ++ ++ + +++F + C P +
Sbjct: 1372 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1430
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 459
N T PG F C PGY L+ I C+ + W + P C A CGG
Sbjct: 1431 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1486
Query: 460 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 518
L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG
Sbjct: 1487 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1546
Query: 519 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 578
++ ++ + + R+ SS + L F++ GF L +K R ++C
Sbjct: 1547 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1599
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 634
P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1600 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH--AP 1657
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCL 664
C + G T +P V + C+
Sbjct: 1658 CGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1685
Score = 170 bits (431), Expect = 5e-42
Identities = 192/786 (24%), Positives = 300/786 (38%), Gaps = 104/786 (13%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C N++ G++ SP+ P + DC ++I V Y I + + ++ + L +
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1540
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 216
G +NS ++G Q + P +N + L F+S GF + Y+A
Sbjct: 1541 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1592
Query: 217 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 273
L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P
Sbjct: 1593 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 274 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 331
SC A CG + G ++SP +VG N + F + SL +
Sbjct: 1653 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1708
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 389
D + V G + S ++ E +S + + S P ++A
Sbjct: 1709 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1768
Query: 390 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 445
+C + P G E+ G+ F C PGY L AI C V +
Sbjct: 1769 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1823
Query: 446 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 504
WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1824 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1883
Query: 505 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 564
D L +DG +A L G L S+ +L L FQ+ GF L
Sbjct: 1884 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 1939
Query: 565 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 622
+ + D+CPE P G + + G V+++QC+ GY L G +TC W
Sbjct: 1940 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 1996
Query: 623 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 668
+ P C I++ PG + P+G H+Q+ +
Sbjct: 1997 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2056
Query: 669 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 697
+ + S +T T K + A +
Sbjct: 2057 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2116
Query: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757
+ C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P
Sbjct: 2117 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2174
Query: 758 CKVAYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQG 815
C E L + T P E N L + + G+G+YI +T LQ
Sbjct: 2175 C-----EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQT 2226
Query: 816 KSLFGF 821
+ ++ F
Sbjct: 2227 EPIYDF 2232
Score = 167 bits (422), Expect = 5e-41
Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 161
C +N+ G SP+ C + I V I+I + +L + L
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500
Query: 162 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 220
+ GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC
Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 560
Query: 221 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
G P P +G F C G++L GE++++C + W+ P C+ C
Sbjct: 561 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 618
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 340
A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G
Sbjct: 619 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 677
Query: 341 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 400
SP SP++ +VP L S++ L +E ++ + ++ + F + C P +
Sbjct: 678 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 736
Query: 401 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 460
N ++ G+ + C G+ ++ G + + W+ P C A CGG
Sbjct: 737 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 794
Query: 461 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 519
S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 795 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 854
Query: 520 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 578
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 855 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 910
Query: 579 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 638
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 911 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 964
Query: 639 GEIANGHRTASDAGFP 654
G++ T G+P
Sbjct: 965 GDVRGPSGTILSPGYP 980
Score = 131 bits (330), Expect = 2e-30
Identities = 154/572 (26%), Positives = 231/572 (40%), Gaps = 68/572 (11%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + G +ESP G P G +CT+ I I+I Q+ L +E + L L
Sbjct: 65 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 121
Query: 163 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 221
G R L + S + L S GF+++Y+ S CG
Sbjct: 122 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 222 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 277
P P G + T G + C +GY L G L C+ + SW+ P C A
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 337
+CGGT+ ++ G I SP N C W I A G + L F ++E D L +
Sbjct: 240 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 297
Query: 338 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE----EDR 393
G P P I+ S M+ P +IS+ L + ++++ S ++ + + R
Sbjct: 298 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSR 353
Query: 394 CFAPF-----------LAHGNVTTT-----DP-----------EYRPGALATFSCLPGYA 426
F F L G + T DP ++ G+ FSC Y
Sbjct: 354 GFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYV 413
Query: 427 LEPPGPPNAIECVDPTE--PHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDC 483
L+ +I C E W+D P CK CG L P+G SP++P Y C
Sbjct: 414 LQ---GAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQC 470
Query: 484 VWGV-HVQEEKRILLQVEILNVREG-DMLTLFDGD--GPSARVLAQLRGPQPRRRLLSSG 539
VW + V K I + E ++ G D LT+ DG G VL L G ++S
Sbjct: 471 VWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMS 530
Query: 540 PDLTLQFQAPPGPPNPGLGQ-GFVLHFKEVPRNDTCPELPPPEWGWRTASHGD-LIRGTV 597
+ L Q + +G GF +++KE+ + ++C + P +G R GD V
Sbjct: 531 SQMWLHLQT-----DESVGSVGFKVNYKEIEK-ESCGDPGTPLYGIR---EGDGFSNRDV 581
Query: 598 LTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
L ++C+ G+EL+G + CQ + WSA P C
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 128 bits (321), Expect = 3e-29
Identities = 132/581 (22%), Positives = 224/581 (38%), Gaps = 88/581 (15%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 162
C + G + SP + DCT++I PG I + + ++ + L +
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNA---DCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI 297
Query: 163 AGGGSP-------GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 215
G P + P +++N N L LHF + R GF YQ
Sbjct: 298 EGSEPPTIWLSGMNIPPPIISNK-------------NWLRLHFVTDSNHRYRGFSAPYQV 344
Query: 216 Y-----------------------LLS----------CGFPPRPAHGDVSVTDLHPGGTA 242
+L+ C P P +G +D G T
Sbjct: 345 KKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTV 404
Query: 243 TFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-MASCGGTIHNATLGRIVSPEPGGA 299
F CD Y LQG +++ C + +W+ P C + +CG + + G SP
Sbjct: 405 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPS-GTFTSPNFPFQ 463
Query: 300 VGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLMVRSGGSPLSP-----VIYDSDMD 353
N C WVI A + + ++FE L+ D L + GG P V+ S +
Sbjct: 464 YDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVP 523
Query: 354 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP 413
D+ ++S + +++ L ++ + + ++ E++ C P + D +
Sbjct: 524 DL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGD-GFSN 578
Query: 414 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW 473
+ F C G+ L +I C + + W+ P C C + P G VLSPD+
Sbjct: 579 RDVLRFECQFGFELI---GEKSIVCQENNQ--WSANIPICIFPCLSNFTAPMGTVLSPDY 633
Query: 474 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPSARVLAQLRGPQPR 532
P+ Y +C+W + RI L ++ + D L + DGD P + +L G +
Sbjct: 634 PEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVP 693
Query: 533 RRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDL 592
L S+ L L+FQA + G+GF + + N+ CP+ P R + L
Sbjct: 694 SHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFGHNE-CPDPGIPINARRFGDNFQL 748
Query: 593 IRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAAPPAC 629
G+ ++ CE G+ + G++ +TC + WS P C
Sbjct: 749 --GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%)
Query: 591 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 648
D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG
Sbjct: 3019 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3077
Query: 649 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P
Sbjct: 3078 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3129
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
G + YQ+ + F C F L+G T C W+ P C
Sbjct: 3130 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3175
Score = 92.0 bits (227), Expect = 2e-18
Identities = 106/445 (23%), Positives = 163/445 (36%), Gaps = 75/445 (16%)
Query: 272 TPSCMA----SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 327
T SC+ +CGGT+ G I SP C WVI A E R+ + F+ +L
Sbjct: 54 TVSCVKGFIYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFAL 112
Query: 328 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRF 386
+E+ D L + G P + + + ++ +S++ + L S+ + + +
Sbjct: 113 EEEYDYLSLYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 387 EAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEP 444
E + C P + V + G +SC+ GY L+ G P + C+
Sbjct: 171 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTA 226
Query: 445 HWNDTEPACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 502
W+ P C+A CGG + +G++ SP +P Y DC W + + I L
Sbjct: 227 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 286
Query: 503 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 562
+ E +G P L+ + P P ++S+ L L F G +
Sbjct: 287 QMEEKYDYLEIEGSEPPTIWLSGMNIPPP---IISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Query: 563 LH---------FKEVPRNDTCPELPP-PEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD 612
+ FK P D + E G +TAS+
Sbjct: 344 VKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASN----------------------- 380
Query: 613 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 672
C DPGE NG R SD F +GS VQ+ C Y L+GA
Sbjct: 381 ---------------------LCPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGA 417
Query: 673 AMLTCYSRDTGTPKWSDRVPKCALK 697
+TC WSD P C +K
Sbjct: 418 KSITCQRIAEVFAAWSDHRPVCKVK 442
Score = 88.2 bits (217), Expect = 3e-17
Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K
Sbjct: 2886 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 2942
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
+ C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P
Sbjct: 2943 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 2997
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 750
C + C +PG+P NG + Y Y G+++ + C G+ EL G TC
Sbjct: 2998 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3051
Query: 751 WTSQPPLCK 759
W+ P C+
Sbjct: 3052 WSGVMPTCR 3060
Score = 84.0 bits (206), Expect = 6e-16
Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 571 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2763 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2822
Query: 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2823 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 2875
Query: 691 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 749
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 2876 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 2931
Query: 750 QWTSQPPLCK 759
WT + P CK
Sbjct: 2932 SWTGRQPECK 2941
Score = 83.2 bits (204), Expect = 9e-16
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3063 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3119
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3120 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3173
Query: 693 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3174 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3230
Query: 752 TSQPPLC 758
+ P C
Sbjct: 3231 SGIQPEC 3237
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 653
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2667 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2722
Query: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 713
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2723 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2776
Query: 714 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
H + G + + C G+ L G + C P QW P C
Sbjct: 2777 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2821
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2589 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2645
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2646 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2699
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 752
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2700 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2753
Query: 753 SQPPLCKV 760
PP+CKV
Sbjct: 2754 HPPPMCKV 2761
Score = 53.5 bits (127), Expect = 8e-07
Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 166 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 219
G PG+ P + + G + S T + L QS R + G Q + +
Sbjct: 2827 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 2886
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 277
CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 2887 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 2943
Query: 278 SCG--GTIHNATLGRI 291
CG GT N + RI
Sbjct: 2944 QCGNPGTTANGKVFRI 2959
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 569 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 628
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3178 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3236
Query: 629 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 684
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3237 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3289
Query: 685 PKWSDRVPKC 694
W+ +VP C
Sbjct: 3290 --WTGKVPIC 3297
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 753
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 173 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 754 QPPLCK 759
P+C+
Sbjct: 231 PVPICR 236
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 699 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 756
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1595 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 757 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 807
C + V P G N +I +P V+ L V
Sbjct: 1653 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1712
Query: 808 IYYTKLQGKSLF-GFSGSHSYSPITVES 834
+Y Q SL SGSHS + + S
Sbjct: 1713 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1740
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276
++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+
Sbjct: 3062 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3118
Query: 277 AS-CG 280
CG
Sbjct: 3119 PKFCG 3123
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 696 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 755
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 555 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 610
Query: 756 PLC 758
P+C
Sbjct: 611 PIC 613
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2587 VISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2644
Query: 277 ASCGGTIHNATLGRIVSPEPG 297
A G G+++ G
Sbjct: 2645 AGHCGIPELIVNGQVIGENYG 2665
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 219 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3182 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3238
Score = 39.7 bits (91), Expect = 0.012
Identities = 19/66 (28%), Positives = 29/66 (43%)
Query: 695 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 754
A + C P N ++ G+ +R+ C GF L+G +TC G Q
Sbjct: 2285 AYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGA 2344
Query: 755 PPLCKV 760
PP+C+V
Sbjct: 2345 PPVCQV 2350
Score = 38.5 bits (88), Expect = 0.027
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 758
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 382 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Query: 759 KV 760
KV
Sbjct: 440 KV 441
Score = 38.5 bits (88), Expect = 0.027
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 220 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 278
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2648 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNWSGQLPSCVPVS 2705
Query: 279 CG 280
CG
Sbjct: 2706 CG 2707
Score = 38.5 bits (88), Expect = 0.027
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 273
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3001 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3057
Query: 274 SCMASCGGTIHNATLGRI 291
+C A T + GR+
Sbjct: 3058 TCRAVTCPTPPQISNGRL 3075
Score = 35.8 bits (81), Expect = 0.17
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2704 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2759
Score = 35.0 bits (79), Expect = 0.30
Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Query: 214 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 272
+ ++ CG P P + +S G T + C L G+ + C LNG W+G
Sbjct: 2820 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 2876
Query: 273 PSCMASCGGT 282
P C GT
Sbjct: 2877 PHCSGDATGT 2886
Score = 34.3 bits (77), Expect = 0.50
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 219 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 276
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3241 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3298
Query: 277 A 277
A
Sbjct: 3299 A 3299
Score = 34.3 bits (77), Expect = 0.50
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 771 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 827
L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3442 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3499
Query: 828 SPITVESDFSNPLYE 842
++ F NP+Y+
Sbjct: 3500 ENNNGQAAFENPMYD 3514
Score = 31.6 bits (70), Expect = 3.3
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 586 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 630
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3247 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3298
Score = 31.2 bits (69), Expect = 4.3
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 217 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 271
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2761 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2817
Query: 272 TPSC-MASCG--GTIHNATL 288
P C M CG G NA L
Sbjct: 2818 LPECIMIDCGHPGVPPNAVL 2837
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 102 bits (255), Expect = 1e-21
Identities = 146/617 (23%), Positives = 225/617 (36%), Gaps = 120/617 (19%)
Query: 220 CGFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 275
C PP HG+ + + + PG + C+ GY L+G +L C + W+ E P C
Sbjct: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--PQGDWSPEAPRCA 1704
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL------HLHF------- 322
+ SC + GR++ P + L + EG RL H
Sbjct: 1705 VKSCDDFLGQLPHGRVLFP-----LNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1759
Query: 323 -------ERVSLDEDNDRLMVRSGGSPLSPVIYDSDM----DDVPERGL---------IS 362
E + L R G+P + Y ++ D P+RG+ I
Sbjct: 1760 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1819
Query: 363 DAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCL 422
+ + +PA LS+R + F PF A + D E+ G + C
Sbjct: 1820 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF-PF-ASPTIPINDFEFPVGTSLNYECR 1877
Query: 423 PGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY----- 477
PGY G +I C++ W+ E C+ G EP ++ + +
Sbjct: 1878 PGYF----GKMFSISCLENLV--WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1931
Query: 478 -----------SPGQDC-VWGVHVQEEKRILLQVEILNVR-------------------E 506
SP C V G +V +K+ + EI++
Sbjct: 1932 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI-CEIISCEPPPTISNGDFYSNNRTSFHN 1990
Query: 507 GDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 566
G ++T GP L +L G R + + D + + P P +
Sbjct: 1991 GTVVTYQCHTGPDGEQLFELVG---ERSIYCTSKDDQVGVWSSPPP-------------R 2034
Query: 567 EVPRND-TCPELPPPEWGWRTASHGDLIRGT-VLTYQCEPGYELLGSDILTCQWDLSWSA 624
+ N T PE+ E R + T ++ ++C+PG+ ++GS + CQ + W
Sbjct: 2035 CISTNKCTAPEV---ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
Query: 625 APPACQKIMTCADPGEIANGHRTAS-DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 683
P C ++ C P EI +G T S F G V Y C P Y L GAA L C T
Sbjct: 2092 KLPHCSRV--CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TP 2145
Query: 684 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 743
WS P+C +K +P + L + Q G + F C EGF L G C
Sbjct: 2146 QGDWSPEAPRCTVKSCDDFLGQLPHG--RVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 2203
Query: 744 V-PGHPSQWTSQPPLCK 759
V G + W S P+C+
Sbjct: 2204 VLAGMKALWNSSVPVCE 2220
Score = 89.0 bits (219), Expect = 2e-17
Identities = 140/589 (23%), Positives = 222/589 (37%), Gaps = 122/589 (20%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Query: 277 A-SCG--GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 333
CG TI N I + G +T R + + GR++ FE V
Sbjct: 1513 RIPCGLPPTIANGDF--ISTNRENFHYGSVVTYRCNL-GSRGRKV---FELVG------- 1559
Query: 334 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 393
P IY + DD + G+ S PA ++ ++
Sbjct: 1560 ----------EPSIYCTSNDD--QVGIWSG------------PAPQCIIP--------NK 1587
Query: 394 CFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 452
C P + +G + + + + + F C PG+ ++ P ++C + W P+
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP---RRVKCQALNK--WEPELPS 1642
Query: 453 CKAMCGGELSEPAGVVL----SPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGD 508
C +C +P +L +P ++SPGQ+ + + R + +GD
Sbjct: 1643 CSRVC-----QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC--TPQGD 1695
Query: 509 MLTLFDGDGPSARVLA--QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 566
+ + P V + G P R+L L LQ A +GF L
Sbjct: 1696 ----WSPEAPRCAVKSCDDFLGQLPHGRVLFP---LNLQLGAKVSFV---CDEGFRLKGS 1745
Query: 567 EVPR----------NDT--------CPELPPPEWGWRTAS-HGDLIRGTVLTYQCEPG-- 605
V N++ CP P G T + GD+ G ++Y C+P
Sbjct: 1746 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1805
Query: 606 ----YELLGSDILTCQWDLS----WSAAPPACQKIMT---CADPGEIANGHRTA--SDAG 652
+ L+G + C D WS+ P C+ + C P + T +D
Sbjct: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1865
Query: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712
FPVG+ + Y C PGY ++C WS C K C P P NG
Sbjct: 1866 FPVGTSLNYECRPGY-FGKMFSISCLENLV----WSSVEDNCRRK--SCGPPPEPFNGMV 1918
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKV 760
+ Q G ++ + C EGF LIG + TC V G+ W + P+C++
Sbjct: 1919 HI-NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEI 1966
Score = 87.4 bits (215), Expect = 5e-17
Identities = 143/603 (23%), Positives = 229/603 (37%), Gaps = 113/603 (18%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 289
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 1275 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 1334
Query: 290 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 349
+ + P G N TC H +R + + +R P ++
Sbjct: 1335 KPLEVFPFGKA-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
Query: 350 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 401
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 1382 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 1438
Query: 402 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 438
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 1439 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1495
Query: 439 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRIL 496
+ HW+ P C+ + CG + G +S + +++ G + ++ R +
Sbjct: 1496 ILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNLGSRGRKV 1554
Query: 497 LQV----EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 546
++ I D + ++ G P + + P +L S + ++F
Sbjct: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1614
Query: 547 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 589
+ PG FV+ + PR C PELP PPE G T SH
Sbjct: 1615 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSH 1662
Query: 590 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 647
D G + Y CEPGY+L G+ L C WS P C + +C D G++ +G R
Sbjct: 1663 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC-AVKSCDDFLGQLPHG-RV 1720
Query: 648 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 707
+G+ V + C G+ L+G+++ C + W++ VP C ++ C NP
Sbjct: 1721 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS-LWNNSVPVC--EHIFCPNPPAI 1777
Query: 708 ENGYQT-LYKHHYQAGESLRFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLC 758
NG T G+ + + C F LIGE TI C P W+S P C
Sbjct: 1778 LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRC 1837
Query: 759 KVA 761
+++
Sbjct: 1838 ELS 1840
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 289
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 375 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
Query: 290 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 349
+ + P G N TC H +R + + +R P ++
Sbjct: 435 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 350 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 401
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 482 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 538
Query: 402 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 438
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 595
Query: 439 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 492
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 596 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 654
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 546
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 714
Query: 547 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 589
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 715 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 762
Query: 590 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 647
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 763 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 820
Query: 648 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 707
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 821 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 877
Query: 708 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 758
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 878 PNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
Query: 759 KV 760
+
Sbjct: 938 GI 939
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 289
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 825 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
Query: 290 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 349
+ + P G N TC H +R + + +R P ++
Sbjct: 885 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
Query: 350 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 401
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 932 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
Query: 402 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 438
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 989 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1045
Query: 439 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 492
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 1046 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 1104
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 546
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1164
Query: 547 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 589
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 1165 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 1212
Query: 590 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 647
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 1213 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 1270
Query: 648 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 707
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 1271 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 1327
Query: 708 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 758
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 1328 PNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 1387
Query: 759 KV 760
+
Sbjct: 1388 GI 1389
Score = 81.3 bits (199), Expect = 4e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 331
G G +S ++ + GR++ FE V ++
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 669
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 380
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 670 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 381 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 434
+L E C P + H T D + + PG +SC PGY L
Sbjct: 730 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 786
Query: 435 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 492
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 787 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 829
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 552
++ + EG L G S VLA + L +S + Q P P
Sbjct: 830 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 875
Query: 553 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 609
P G G L + N TC P P+ RGT ++L+
Sbjct: 876 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 913
Query: 610 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 663
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 664 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 723
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 974 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1025
Query: 724 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 759
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Score = 81.3 bits (199), Expect = 4e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 331
G G +S ++ + GR++ FE V ++
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 1119
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 380
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 1120 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 1179
Query: 381 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 434
+L E C P + H T D + + PG +SC PGY L
Sbjct: 1180 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 1236
Query: 435 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 492
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 1237 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 1279
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 552
++ + EG L G S VLA + L +S + Q P P
Sbjct: 1280 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 1325
Query: 553 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 609
P G G L + N TC P P+ RGT ++L+
Sbjct: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCD--PHPD------------RGT--------SFDLI 1363
Query: 610 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 663
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 1364 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 1423
Query: 664 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 723
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 1424 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1475
Query: 724 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 759
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1476 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Score = 80.5 bits (197), Expect = 6e-15
Identities = 137/577 (23%), Positives = 212/577 (36%), Gaps = 103/577 (17%)
Query: 219 SCGFPPRPAHGDVSVTD-LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V + G + C GY+L G + C ++G W+ ETP C
Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 331
G T G +S ++ + GR++ FE V ++
Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 219
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 380
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 220 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 279
Query: 381 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 434
+L E C P + H T D + + PG +SC PGY L
Sbjct: 280 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 336
Query: 435 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 492
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 379
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 552
++ + EG L G S VLA + L +S + Q P P
Sbjct: 380 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 425
Query: 553 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 609
P G G L + N TC P P+ RGT ++L+
Sbjct: 426 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 463
Query: 610 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 663
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 664 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 723
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 524 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 575
Query: 724 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 759
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 576 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Score = 74.7 bits (182), Expect = 3e-13
Identities = 95/386 (24%), Positives = 154/386 (39%), Gaps = 59/386 (15%)
Query: 414 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPD 472
G+ +SC GY L G +A + W++ P C + CG + G +S +
Sbjct: 124 GSQIKYSCTKGYRLI--GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTN 181
Query: 473 WPQSYSPGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRG 528
+++ G C G ++ ++ + I D + ++ G P + +
Sbjct: 182 -RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Query: 529 PQPRRRLLSSGP------DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC-------P 575
P +L S + ++F+ PG FV+ + PR C P
Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPG---------FVM---KGPRRVKCQALNKWEP 288
Query: 576 ELP--------PPE--WGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSA 624
ELP PP+ RT D G + Y CEPGY+L G+ + C WS
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 625 APPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 683
A P C+ + +C D G++ NG R +G+ V + C G+ L+G++ C
Sbjct: 349 AAPTCE-VKSCDDFMGQLLNG-RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
Query: 684 TPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFC------YEGFELI 736
+ W+ VP C + C +P V NG T + G+++ + C F+LI
Sbjct: 407 S-LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
Query: 737 GEVTITCV--PGHPSQWTSQPPLCKV 760
GE TI C P W+S P C +
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGI 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/584 (22%), Positives = 205/584 (35%), Gaps = 72/584 (12%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM----------------- 276
+L G +F CD G++L+G C L G R WN P C
Sbjct: 1725 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG 1784
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERV-SLDEDNDRLM 335
G + + P P + NL I H V S L
Sbjct: 1785 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP----HGNGVWSSPAPRCELS 1840
Query: 336 VRSGGSPL-------SPVIYDSDMDDVPERGLISDAQSLYV-ELLSETPANPLLLSLRFE 387
VR+G SP I +D + L + + Y ++ S + L+ S +
Sbjct: 1841 VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED 1900
Query: 388 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 447
C P + + + + G+ +SC G+ L G P+ V W+
Sbjct: 1901 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLI--GSPSTTCLVSGNNVTWD 1958
Query: 448 DTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQV---- 499
P C+ + EP + + D+ S+ G + H + L ++
Sbjct: 1959 KKAPICEIIS----CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
Query: 500 EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLT--LQFQAPPGPP 553
I + D + ++ P + P+ + G LT ++F+ PG
Sbjct: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
Query: 554 NPGLGQ-GFVLHFKEVPRNDTCPEL--PPPE--WGWRTASHGDLIR-GTVLTYQCEPGYE 607
G + + P+ C + PPPE G T SH D G + Y CEP Y+
Sbjct: 2075 MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYD 2134
Query: 608 LLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPG 666
L G+ L C WS P C + +C D G++ +G R +G+ V + C G
Sbjct: 2135 LRGAASLHCTPQGDWSPEAPRC-TVKSCDDFLGQLPHG-RVLLPLNLQLGAKVSFVCDEG 2192
Query: 667 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH-HYQAGESL 725
+ L+G + C W+ VP C + C NP NG T G+ +
Sbjct: 2193 FRLKGRSASHCVLAGM-KALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEI 2249
Query: 726 RFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLCKVA 761
+ C F LIGE +I C P W+S P C+++
Sbjct: 2250 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 2293
Score = 68.9 bits (167), Expect = 2e-11
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 26/229 (11%)
Query: 549 PPGPPNPGL----GQGFVLHFKEVPRNDTCPELPPPEW-----GWRTASHGDLIRGTVLT 599
P GPP PGL G + + + PEW + GT L
Sbjct: 11 PVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLN 70
Query: 600 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 659
Y+C PGY I+ C + W+ A C++ +C +P + NG G GS +
Sbjct: 71 YECRPGYSGRPFSII-CLKNSVWTGAKDRCRR-KSCRNPPDPVNG-MVHVIKGIQFGSQI 127
Query: 660 QYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKCALKYEPC-LNPGVPENGYQTLYKH 717
+Y C GY L G++ TC S DT W + P C PC L P + + + +
Sbjct: 128 KYSCTKGYRLIGSSSATCIISGDTVI--WDNETPIC--DRIPCGLPPTITNGDFISTNRE 183
Query: 718 HYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLC 758
++ G + + C G FEL+GE +I C W+ P C
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQ---WDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 651
G +++ C+ G+ L G C W+++ P C++I C +P I NG T +
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIF-CPNPPAILNGRHTGTPF 2240
Query: 652 G-FPVGSHVQYRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLN 703
G P G + Y C ++L G + + C S G WS P+C L C +
Sbjct: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
Query: 704 PGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
P +NG Y + Y G ++ + C G+ L+G+ I C W+ CK
Sbjct: 2301 PPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQGIWSQLDHYCK 2355
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 574 CPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
CP P + G H L + G ++Y C+PGY L+G + C WS C+++
Sbjct: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 2357
Query: 633 MTCADPGEIANG--HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690
C+ P NG + G +V +C GY+LEG+ C + D +W
Sbjct: 2358 -NCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD----RWDPP 2411
Query: 691 VPKCALKYEPCLNPG 705
+ KC + L G
Sbjct: 2412 LAKCTSRTHDALIVG 2426
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC- 275
SCG PP P +G V + TD G T + C+ G++L G + CL +G +W+ + P C
Sbjct: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965
Query: 276 MASC 279
+ SC
Sbjct: 1966 IISC 1969
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 218 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 266
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 614 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
Query: 267 SWNGETPSCMASCGGTIHNATLGRIVS 293
W+G P C+ T N G +VS
Sbjct: 674 IWSGPAPQCIIPNKCTPPNVENGILVS 700
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 218 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 266
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 267 SWNGETPSCMASCGGTIHNATLGRIVS 293
W+G P C+ T N G +VS
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVS 1150
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 218 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 266
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
Query: 267 SWNGETPSCMASCGGTIHNATLGRIVS 293
W+G P C+ T N G +VS
Sbjct: 1574 IWSGPAPQCIIPNKCTPPNVENGILVS 1600
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 102 bits (255), Expect = 1e-21
Identities = 146/617 (23%), Positives = 225/617 (36%), Gaps = 120/617 (19%)
Query: 220 CGFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 275
C PP HG+ + + + PG + C+ GY L+G +L C + W+ E P C
Sbjct: 1197 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--PQGDWSPEAPRCA 1254
Query: 276 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL------HLHF------- 322
+ SC + GR++ P + L + EG RL H
Sbjct: 1255 VKSCDDFLGQLPHGRVLFP-----LNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1309
Query: 323 -------ERVSLDEDNDRLMVRSGGSPLSPVIYDSDM----DDVPERGL---------IS 362
E + L R G+P + Y ++ D P+RG+ I
Sbjct: 1310 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1369
Query: 363 DAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCL 422
+ + +PA LS+R + F PF A + D E+ G + C
Sbjct: 1370 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF-PF-ASPTIPINDFEFPVGTSLNYECR 1427
Query: 423 PGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY----- 477
PGY G +I C++ W+ E C+ G EP ++ + +
Sbjct: 1428 PGYF----GKMFSISCLENLV--WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1481
Query: 478 -----------SPGQDC-VWGVHVQEEKRILLQVEILNVR-------------------E 506
SP C V G +V +K+ + EI++
Sbjct: 1482 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI-CEIISCEPPPTISNGDFYSNNRTSFHN 1540
Query: 507 GDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 566
G ++T GP L +L G R + + D + + P P +
Sbjct: 1541 GTVVTYQCHTGPDGEQLFELVG---ERSIYCTSKDDQVGVWSSPPP-------------R 1584
Query: 567 EVPRND-TCPELPPPEWGWRTASHGDLIRGT-VLTYQCEPGYELLGSDILTCQWDLSWSA 624
+ N T PE+ E R + T ++ ++C+PG+ ++GS + CQ + W
Sbjct: 1585 CISTNKCTAPEV---ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 1641
Query: 625 APPACQKIMTCADPGEIANGHRTAS-DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 683
P C ++ C P EI +G T S F G V Y C P Y L GAA L C T
Sbjct: 1642 KLPHCSRV--CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TP 1695
Query: 684 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 743
WS P+C +K +P + L + Q G + F C EGF L G C
Sbjct: 1696 QGDWSPEAPRCTVKSCDDFLGQLPHG--RVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 1753
Query: 744 V-PGHPSQWTSQPPLCK 759
V G + W S P+C+
Sbjct: 1754 VLAGMKALWNSSVPVCE 1770
Score = 89.0 bits (219), Expect = 2e-17
Identities = 140/589 (23%), Positives = 222/589 (37%), Gaps = 122/589 (20%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Query: 277 A-SCG--GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 333
CG TI N I + G +T R + + GR++ FE V
Sbjct: 1063 RIPCGLPPTIANGDF--ISTNRENFHYGSVVTYRCNL-GSRGRKV---FELVG------- 1109
Query: 334 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 393
P IY + DD + G+ S PA ++ ++
Sbjct: 1110 ----------EPSIYCTSNDD--QVGIWSG------------PAPQCIIP--------NK 1137
Query: 394 CFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 452
C P + +G + + + + + F C PG+ ++ P ++C + W P+
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP---RRVKCQALNK--WEPELPS 1192
Query: 453 CKAMCGGELSEPAGVVL----SPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGD 508
C +C +P +L +P ++SPGQ+ + + R + +GD
Sbjct: 1193 CSRVC-----QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC--TPQGD 1245
Query: 509 MLTLFDGDGPSARVLA--QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 566
+ + P V + G P R+L L LQ A +GF L
Sbjct: 1246 ----WSPEAPRCAVKSCDDFLGQLPHGRVLFP---LNLQLGAKVSFV---CDEGFRLKGS 1295
Query: 567 EVPR----------NDT--------CPELPPPEWGWRTAS-HGDLIRGTVLTYQCEPG-- 605
V N++ CP P G T + GD+ G ++Y C+P
Sbjct: 1296 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1355
Query: 606 ----YELLGSDILTCQWDLS----WSAAPPACQKIMT---CADPGEIANGHRTA--SDAG 652
+ L+G + C D WS+ P C+ + C P + T +D
Sbjct: 1356 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1415
Query: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712
FPVG+ + Y C PGY ++C WS C K C P P NG
Sbjct: 1416 FPVGTSLNYECRPGY-FGKMFSISCLENLV----WSSVEDNCRRK--SCGPPPEPFNGMV 1468
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKV 760
+ Q G ++ + C EGF LIG + TC V G+ W + P+C++
Sbjct: 1469 HI-NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEI 1516
Score = 87.4 bits (215), Expect = 5e-17
Identities = 143/603 (23%), Positives = 229/603 (37%), Gaps = 113/603 (18%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 289
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 825 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
Query: 290 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 349
+ + P G N TC H +R + + +R P ++
Sbjct: 885 KPLEVFPFGKA-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
Query: 350 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 401
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 932 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
Query: 402 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 438
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 989 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1045
Query: 439 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRIL 496
+ HW+ P C+ + CG + G +S + +++ G + ++ R +
Sbjct: 1046 ILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNLGSRGRKV 1104
Query: 497 LQV----EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 546
++ I D + ++ G P + + P +L S + ++F
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1164
Query: 547 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 589
+ PG FV+ + PR C PELP PPE G T SH
Sbjct: 1165 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSH 1212
Query: 590 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 647
D G + Y CEPGY+L G+ L C WS P C + +C D G++ +G R
Sbjct: 1213 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC-AVKSCDDFLGQLPHG-RV 1270
Query: 648 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 707
+G+ V + C G+ L+G+++ C + W++ VP C ++ C NP
Sbjct: 1271 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS-LWNNSVPVC--EHIFCPNPPAI 1327
Query: 708 ENGYQT-LYKHHYQAGESLRFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLC 758
NG T G+ + + C F LIGE TI C P W+S P C
Sbjct: 1328 LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRC 1387
Query: 759 KVA 761
+++
Sbjct: 1388 ELS 1390
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 289
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 375 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
Query: 290 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 349
+ + P G N TC H +R + + +R P ++
Sbjct: 435 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 350 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 401
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 482 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 538
Query: 402 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 438
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 595
Query: 439 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 492
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 596 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 654
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 546
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 714
Query: 547 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 589
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 715 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 762
Query: 590 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 647
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 763 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 820
Query: 648 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 707
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 821 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 877
Query: 708 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 758
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 878 PNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
Query: 759 KV 760
+
Sbjct: 938 GI 939
Score = 81.3 bits (199), Expect = 4e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 331
G G +S ++ + GR++ FE V ++
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 669
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 380
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 670 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 381 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 434
+L E C P + H T D + + PG +SC PGY L
Sbjct: 730 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 786
Query: 435 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 492
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 787 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 829
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 552
++ + EG L G S VLA + L +S + Q P P
Sbjct: 830 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 875
Query: 553 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 609
P G G L + N TC P P+ RGT ++L+
Sbjct: 876 VIPNGRHTGKPLEVFPFGKAVNYTCD--PHPD------------RGT--------SFDLI 913
Query: 610 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 663
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 664 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 723
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 974 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1025
Query: 724 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 759
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Score = 80.5 bits (197), Expect = 6e-15
Identities = 137/577 (23%), Positives = 212/577 (36%), Gaps = 103/577 (17%)
Query: 219 SCGFPPRPAHGDVSVTD-LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 276
SC PP P +G V V + G + C GY+L G + C ++G W+ ETP C
Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 331
G T G +S ++ + GR++ FE V ++
Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 219
Query: 332 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 380
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 220 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 279
Query: 381 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 434
+L E C P + H T D + + PG +SC PGY L
Sbjct: 280 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 336
Query: 435 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 492
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 379
Query: 493 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 552
++ + EG L G S VLA + L +S + Q P P
Sbjct: 380 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 425
Query: 553 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 609
P G G L + N TC P P+ RGT ++L+
Sbjct: 426 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 463
Query: 610 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 663
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 664 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 723
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 524 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 575
Query: 724 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 759
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 576 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Score = 74.7 bits (182), Expect = 3e-13
Identities = 95/386 (24%), Positives = 154/386 (39%), Gaps = 59/386 (15%)
Query: 414 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPD 472
G+ +SC GY L G +A + W++ P C + CG + G +S +
Sbjct: 124 GSQIKYSCTKGYRLI--GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTN 181
Query: 473 WPQSYSPGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRG 528
+++ G C G ++ ++ + I D + ++ G P + +
Sbjct: 182 -RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Query: 529 PQPRRRLLSSGP------DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC-------P 575
P +L S + ++F+ PG FV+ + PR C P
Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPG---------FVM---KGPRRVKCQALNKWEP 288
Query: 576 ELP--------PPE--WGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSA 624
ELP PP+ RT D G + Y CEPGY+L G+ + C WS
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 625 APPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 683
A P C+ + +C D G++ NG R +G+ V + C G+ L+G++ C
Sbjct: 349 AAPTCE-VKSCDDFMGQLLNG-RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
Query: 684 TPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFC------YEGFELI 736
+ W+ VP C + C +P V NG T + G+++ + C F+LI
Sbjct: 407 S-LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
Query: 737 GEVTITCV--PGHPSQWTSQPPLCKV 760
GE TI C P W+S P C +
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGI 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/584 (22%), Positives = 205/584 (35%), Gaps = 72/584 (12%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM----------------- 276
+L G +F CD G++L+G C L G R WN P C
Sbjct: 1275 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG 1334
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERV-SLDEDNDRLM 335
G + + P P + NL I H V S L
Sbjct: 1335 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP----HGNGVWSSPAPRCELS 1390
Query: 336 VRSGGSPL-------SPVIYDSDMDDVPERGLISDAQSLYV-ELLSETPANPLLLSLRFE 387
VR+G SP I +D + L + + Y ++ S + L+ S +
Sbjct: 1391 VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED 1450
Query: 388 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 447
C P + + + + G+ +SC G+ L G P+ V W+
Sbjct: 1451 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLI--GSPSTTCLVSGNNVTWD 1508
Query: 448 DTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQV---- 499
P C+ + EP + + D+ S+ G + H + L ++
Sbjct: 1509 KKAPICEIIS----CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 1564
Query: 500 EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLT--LQFQAPPGPP 553
I + D + ++ P + P+ + G LT ++F+ PG
Sbjct: 1565 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 1624
Query: 554 NPGLGQ-GFVLHFKEVPRNDTCPEL--PPPE--WGWRTASHGDLIR-GTVLTYQCEPGYE 607
G + + P+ C + PPPE G T SH D G + Y CEP Y+
Sbjct: 1625 MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYD 1684
Query: 608 LLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPG 666
L G+ L C WS P C + +C D G++ +G R +G+ V + C G
Sbjct: 1685 LRGAASLHCTPQGDWSPEAPRC-TVKSCDDFLGQLPHG-RVLLPLNLQLGAKVSFVCDEG 1742
Query: 667 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH-HYQAGESL 725
+ L+G + C W+ VP C + C NP NG T G+ +
Sbjct: 1743 FRLKGRSASHCVLAGM-KALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEI 1799
Query: 726 RFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLCKVA 761
+ C F LIGE +I C P W+S P C+++
Sbjct: 1800 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 1843
Score = 68.9 bits (167), Expect = 2e-11
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 26/229 (11%)
Query: 549 PPGPPNPGL----GQGFVLHFKEVPRNDTCPELPPPEW-----GWRTASHGDLIRGTVLT 599
P GPP PGL G + + + PEW + GT L
Sbjct: 11 PVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLN 70
Query: 600 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 659
Y+C PGY I+ C + W+ A C++ +C +P + NG G GS +
Sbjct: 71 YECRPGYSGRPFSII-CLKNSVWTGAKDRCRR-KSCRNPPDPVNG-MVHVIKGIQFGSQI 127
Query: 660 QYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKCALKYEPC-LNPGVPENGYQTLYKH 717
+Y C GY L G++ TC S DT W + P C PC L P + + + +
Sbjct: 128 KYSCTKGYRLIGSSSATCIISGDTVI--WDNETPIC--DRIPCGLPPTITNGDFISTNRE 183
Query: 718 HYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLC 758
++ G + + C G FEL+GE +I C W+ P C
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQ---WDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 651
G +++ C+ G+ L G C W+++ P C++I C +P I NG T +
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIF-CPNPPAILNGRHTGTPF 1790
Query: 652 G-FPVGSHVQYRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLN 703
G P G + Y C ++L G + + C S G WS P+C L C +
Sbjct: 1791 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 1850
Query: 704 PGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
P +NG Y + Y G ++ + C G+ L+G+ I C W+ CK
Sbjct: 1851 PPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQGIWSQLDHYCK 1905
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 574 CPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
CP P + G H L + G ++Y C+PGY L+G + C WS C+++
Sbjct: 1848 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 1907
Query: 633 MTCADPGEIANG--HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 690
C+ P NG + G +V +C GY+LEG+ C + D +W
Sbjct: 1908 -NCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD----RWDPP 1961
Query: 691 VPKCALKYEPCLNPG 705
+ KC + L G
Sbjct: 1962 LAKCTSRTHDALIVG 1976
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 219 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC- 275
SCG PP P +G V + TD G T + C+ G++L G + CL +G +W+ + P C
Sbjct: 1456 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1515
Query: 276 MASC 279
+ SC
Sbjct: 1516 IISC 1519
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 218 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 266
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 614 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
Query: 267 SWNGETPSCMASCGGTIHNATLGRIVS 293
W+G P C+ T N G +VS
Sbjct: 674 IWSGPAPQCIIPNKCTPPNVENGILVS 700
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 218 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 266
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 267 SWNGETPSCMASCGGTIHNATLGRIVS 293
W+G P C+ T N G +VS
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVS 1150
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 97.8 bits (242), Expect = 4e-20
Identities = 138/573 (24%), Positives = 213/573 (37%), Gaps = 98/573 (17%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 277
+ C P +G S TDLH G T T+ C+ G++L+G L CL W+ + PSC A
Sbjct: 2496 IECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLE--TGDWDVDAPSCNA 2553
Query: 278 SCGGTIHNATLGRIVSPEP---GGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 334
IH SP+P G G + + +I ++ F + +
Sbjct: 2554 -----IH------CDSPQPIENGFVEGADYSYGAII-------IYSCFPGFQVAGHAMQT 2595
Query: 335 MVRSGGSPLSPVIYDSDMD-----DVPERGLISDAQSLY------VELLSETPANPLLLS 383
SG S P D D + + D Q + +E+ TP P L
Sbjct: 2596 CEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLG 2655
Query: 384 LRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE 443
+ +E + + T + G + +++C PGY L G P I D T
Sbjct: 2656 AVAKTWENTK--------ESPATHSSNFLYGTMVSYTCNPGYEL--LGNPVLICQEDGT- 2704
Query: 444 PHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 502
WN + P+C ++ C + G + + + C G H+ + L +E
Sbjct: 2705 --WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPG-HILAGSDLRLCLENR 2761
Query: 503 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDL----TLQFQAPPGPPNPGLG 558
+ G P ++ + P P G + TL ++ PG G
Sbjct: 2762 K---------WSGASPRCEAIS-CKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTE 2811
Query: 559 QGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQ------CEPGYELLGSD 612
+ K ++ P P + S +RG T+Q C G+ L G+
Sbjct: 2812 RRTCQDDKNWDEDE--PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGAR 2869
Query: 613 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 672
C + SWS A P C + CA P ++ANG D GF V + C GY L GA
Sbjct: 2870 SRVCLANGSWSGATPDCVPV-RCATPPQLANGVTEGLDYGFM--KEVTFHCHEGYILHGA 2926
Query: 673 AMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE-------NGYQTLYKHHYQAGESL 725
LTC S W +P C +P +N G PE NG+ ++ H Q
Sbjct: 2927 PKLTCQS----DGNWDAEIPLC----KP-VNCGPPEDLAHGFPNGFSFIHGGHIQ----- 2972
Query: 726 RFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
+ C+ G++L G + C+ W+ P C
Sbjct: 2973 -YQCFPGYKLHGNSSRRCLSN--GSWSGSSPSC 3002
Score = 94.4 bits (233), Expect = 4e-19
Identities = 57/162 (35%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 598 LTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGS 657
+T+ C GY L G+ LTCQ D +W A P C K + C P ++A+G + F G
Sbjct: 2913 VTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC-KPVNCGPPEDLAHGF--PNGFSFIHGG 2969
Query: 658 HVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH 717
H+QY+C PGY L G + C S + WS P C PC P Y T+
Sbjct: 2970 HIQYQCFPGYKLHGNSSRRCLSNGS----WSGSSPSCL----PC-RCSTPVIEYGTVNGT 3020
Query: 718 HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
+ G++ R C++GF+L+G ITC QW+S P C+
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEA--DGQWSSGFPHCE 3060
Score = 89.4 bits (220), Expect = 1e-17
Identities = 65/241 (26%), Positives = 100/241 (41%), Gaps = 57/241 (23%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
+C PP E G+ +A D G+ +TYQC GY LLG + C + SW+ P+C +
Sbjct: 1689 SCGVPPPLENGFHSAD--DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV 1746
Query: 633 MTCA----------------------------------------DPGEIANGHRTASDAG 652
CA PG NGH +S
Sbjct: 1747 DECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH--SSGEI 1804
Query: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712
+ VG+ V + C GY L G +TC + +W+ +P C K C P +PENG
Sbjct: 1805 YTVGAEVTFSCQEGYQLMGVTKITCLE----SGEWNHLIPYC--KAVSCGKPAIPENG-- 1856
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC---KVAYEELLDNR 769
+ + + G + + C +G+ L G+ +C+ S W+ PP+C K + E ++N
Sbjct: 1857 CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN--SSWSHSPPVCEPVKCSSPENINNG 1914
Query: 770 K 770
K
Sbjct: 1915 K 1915
Score = 86.3 bits (212), Expect = 1e-16
Identities = 61/189 (32%), Positives = 84/189 (44%), Gaps = 14/189 (7%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
+C E P E G+ + G + V YQC PGY+ +GS + CQ + W + P
Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFESEV-RYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVP 2261
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV- 691
+ C P I NG + F VGS VQ+ C GY L G + TC + KW+ +
Sbjct: 2262 LDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQK----SGKWNKKSN 2315
Query: 692 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
PKC C P + EN Q + K + F C EG L G + C+P QW
Sbjct: 2316 PKC--MPAKCPEPPLLEN--QLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPS--QQW 2369
Query: 752 TSQPPLCKV 760
P+CK+
Sbjct: 2370 NDSFPVCKI 2378
Score = 85.1 bits (209), Expect = 2e-16
Identities = 65/225 (28%), Positives = 93/225 (41%), Gaps = 51/225 (22%)
Query: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 633
CP L RTAS DL G+ + C+PG++L+G+ + C W+ P C++I
Sbjct: 1631 CPRLGGSVPHLRTASE-DLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERI- 1688
Query: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693
+C P + NG +A D F GS V Y+C GY L G + + C T W+ P
Sbjct: 1689 SCGVPPPLENGFHSADD--FYAGSTVTYQCNNGYYLLGDSRMFC----TDNGSWNGVSPS 1742
Query: 694 C-----------ALKYEPCLN----------------------------PGVPENGYQTL 714
C ++ CLN PG PENG+ +
Sbjct: 1743 CLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS- 1801
Query: 715 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
Y G + F C EG++L+G ITC+ +W P CK
Sbjct: 1802 -GEIYTVGAEVTFSCQEGYQLMGVTKITCL--ESGEWNHLIPYCK 1843
Score = 84.3 bits (207), Expect = 4e-16
Identities = 66/188 (35%), Positives = 81/188 (43%), Gaps = 16/188 (8%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 632
+C + PE G+ S + + YQCEPGYEL G+ CQ + WS C K
Sbjct: 3240 SCGKPESPEHGFVVGSKYTF--ESTIIYQCEPGYELEGNRERVCQENRQWSGGVAIC-KE 3296
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
C P E NG A G +V Y C GYSLEG + C T WS VP
Sbjct: 3297 TRCETPLEFLNG--KADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGT----WSHPVP 3350
Query: 693 KCALKYEPCLNPGV-PENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
C K PC P V PEN L + + +++ C EGF L G ITC P W
Sbjct: 3351 LC--KPNPCPVPFVIPENA--LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNP--DETW 3404
Query: 752 TSQPPLCK 759
T C+
Sbjct: 3405 TQTSAKCE 3412
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/159 (32%), Positives = 73/159 (45%), Gaps = 14/159 (8%)
Query: 600 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 659
Y C+PG+EL+G+ C + W P C K + C P EI NG + +D + G V
Sbjct: 2464 YTCKPGFELVGNTTTLCGENGHWLGGKPTC-KAIECLKPKEILNGKFSYTDLHY--GQTV 2520
Query: 660 QYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHY 719
Y C G+ LEG + LTC T W P C + C +P ENG+ + Y
Sbjct: 2521 TYSCNRGFRLEGPSALTCLE----TGDWDVDAPSCNAIH--CDSPQPIENGF--VEGADY 2572
Query: 720 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
G + + C+ GF++ G TC S W+S P C
Sbjct: 2573 SYGAIIIYSCFPGFQVAGHAMQTC---EESGWSSSIPTC 2608
Score = 80.1 bits (196), Expect = 8e-15
Identities = 56/209 (26%), Positives = 95/209 (45%), Gaps = 17/209 (8%)
Query: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 633
C E P G+ + S+ G ++ Y C G+ + G TC+ WS+ P C +
Sbjct: 2146 CGEPPSIMNGYASGSNYSF--GAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPV- 2202
Query: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693
+C +P ++ NG G S V+Y+C PGY G+ + C + W P
Sbjct: 2203 SCGEPPKVENGF-LEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQA----NRHWHSESPL 2257
Query: 694 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 753
+ + C P +NG+ + +++ G ++FFC EG+EL+G+ + TC +W
Sbjct: 2258 MCVPLD-CGKPPPIQNGF--MKGENFEVGSKVQFFCNEGYELVGDSSWTCQKS--GKWNK 2312
Query: 754 QP-PLC---KVAYEELLDNRKLEVTQTTD 778
+ P C K LL+N+ + TT+
Sbjct: 2313 KSNPKCMPAKCPEPPLLENQLVLKELTTE 2341
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/164 (30%), Positives = 73/164 (44%), Gaps = 13/164 (7%)
Query: 596 TVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPV 655
+ L Y+C+PGY L G++ TCQ D +W P C + C+ P ANG + F
Sbjct: 2795 STLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPV-DCSSPPVSANGQVRGDEYTFQ- 2852
Query: 656 GSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLY 715
++Y C G+ LEGA C + + WS P C C P NG
Sbjct: 2853 -KEIEYTCNEGFLLEGARSRVCLANGS----WSGATPDCV--PVRCATPPQLANGVTEGL 2905
Query: 716 KHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
+ + + + F C+EG+ L G +TC W ++ PLCK
Sbjct: 2906 DYGFM--KEVTFHCHEGYILHGAPKLTC--QSDGNWDAEIPLCK 2945
Score = 74.7 bits (182), Expect = 3e-13
Identities = 49/164 (29%), Positives = 76/164 (46%), Gaps = 13/164 (7%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
G+ +TY+C GY L G +C + SWS +PP C+ + C+ P I NG S G
Sbjct: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV-KCSSPENINNGKYILS--GLT 1922
Query: 655 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 714
S Y C GYSL+G +++ C T + W P C L + C P ++ T
Sbjct: 1923 YLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVF--CGEPPAIKDAVIT- 1975
Query: 715 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
+++ ++ + C EG+ L G TI C+ +W+ C
Sbjct: 1976 -GNNFTFRNTVTYTCKEGYTLAGLDTIECLA--DGKWSRSDQQC 2016
Score = 72.0 bits (175), Expect = 2e-12
Identities = 52/170 (30%), Positives = 72/170 (42%), Gaps = 17/170 (10%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
G +T+ C+ GY+L+G +TC W+ P C K ++C P NG + F
Sbjct: 1808 GAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSCGKPAIPENG--CIEELAFT 1864
Query: 655 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP--CLNPGVPENGYQ 712
GS V YRC GY+L G +C + + WS P C EP C +P NG
Sbjct: 1865 FGSKVTYRCNKGYTLAGDKESSCLANSS----WSHSPPVC----EPVKCSSPENINNGKY 1916
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 762
L Y + S + C G+ L G I C W PP C + +
Sbjct: 1917 ILSGLTYLSTAS--YSCDTGYSLQGPSIIECTAS--GIWDRAPPACHLVF 1962
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/163 (31%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 597 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVG 656
V+T+ C+ G+ L G +L C W+ + P C KI+ C P I+ G S A G
Sbjct: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC-KIVLCTPPPLISFGVPIPSSA-LHFG 2401
Query: 657 SHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYK 716
S V+Y C+ G+ L G + C T WS +P+C C P NG +
Sbjct: 2402 STVKYSCVGGFFLRGNSTTLCQPDGT----WSSPLPECV--PVECPQPEEIPNGIIDVQG 2455
Query: 717 HHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
Y + + + C GFEL+G T C G W P CK
Sbjct: 2456 LAYLS--TALYTCKPGFELVGNTTTLC--GENGHWLGGKPTCK 2494
Score = 70.9 bits (172), Expect = 5e-12
Identities = 83/357 (23%), Positives = 132/357 (36%), Gaps = 42/357 (11%)
Query: 417 ATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQ 475
A++SC GY+L+ P + IEC W+ PAC + CG + V+ ++
Sbjct: 1927 ASYSCDTGYSLQGP---SIIECT--ASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTF 1981
Query: 476 SYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRL 535
+ C G + I + R D P + P+ RL
Sbjct: 1982 RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP---IVDHASPETAHRL 2038
Query: 536 --------------LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPE 581
L+ L Q PP + HF E P + + L
Sbjct: 2039 FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL---- 2094
Query: 582 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI-MTCADPGE 640
+ S G+V++++C G+ L S + C W+ +P + Q I + C +P
Sbjct: 2095 ---ESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPS 2151
Query: 641 IANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP 700
I NG+ AS + + G+ V Y C G+ ++G TC T +WS +P C
Sbjct: 2152 IMNGY--ASGSNYSFGAMVAYSCNKGFYIKGEKKSTC----EATGQWSSPIPTC--HPVS 2203
Query: 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757
C P ENG+ E +R+ C G++ +G C W S+ PL
Sbjct: 2204 CGEPPKVENGFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANR--HWHSESPL 2257
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/168 (29%), Positives = 66/168 (39%), Gaps = 13/168 (7%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
G+ + Y C G+ L G+ CQ D +WS+ P C + C P EI NG G
Sbjct: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPV-ECPQPEEIPNG--IIDVQGLA 2457
Query: 655 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 714
S Y C PG+ L G C W P C K CL P NG +
Sbjct: 2458 YLSTALYTCKPGFELVGNTTTLCGENG----HWLGGKPTC--KAIECLKPKEILNGKFSY 2511
Query: 715 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 762
HY G+++ + C GF L G +TC+ W P C +
Sbjct: 2512 TDLHY--GQTVTYSCNRGFRLEGPSALTCL--ETGDWDVDAPSCNAIH 2555
Score = 68.9 bits (167), Expect = 2e-11
Identities = 96/406 (23%), Positives = 145/406 (35%), Gaps = 100/406 (24%)
Query: 416 LATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQ 475
+ TFSC G+ L+ P + ++C+ + WND+ P CK + + P + P
Sbjct: 2344 VVTFSCKEGHVLQGP---SVLKCLPSQQ--WNDSFPVCKIVL---CTPPPLISFGVPIPS 2395
Query: 476 SY-----SPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQ---LR 527
S + CV G ++ G+ TL DG + L + +
Sbjct: 2396 SALHFGSTVKYSCVGGFFLR----------------GNSTTLCQPDGTWSSPLPECVPVE 2439
Query: 528 GPQPRRRLLSSGPDL-------TLQFQAPPGPPNPG-----LGQ-GFVLHFKEVPRNDTC 574
PQP + + D+ T + PG G G+ G L K + C
Sbjct: 2440 CPQPEE-IPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC 2498
Query: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 634
L P E S+ DL G +TY C G+ L G LTC W P+C I
Sbjct: 2499 --LKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAI-H 2555
Query: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
C P I NG +D + G+ + Y C PG+ + G AM TC ++G WS +P C
Sbjct: 2556 CDSPQPIENGFVEGAD--YSYGAIIIYSCFPGFQVAGHAMQTC--EESG---WSSSIPTC 2608
Query: 695 A------------------------------LKYEPCLNPGVP----------ENGYQTL 714
+ P + P P EN ++
Sbjct: 2609 MPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESP 2668
Query: 715 YKH--HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
H ++ G + + C G+EL+G + C W P C
Sbjct: 2669 ATHSSNFLYGTMVSYTCNPGYELLGNPVLIC--QEDGTWNGSAPSC 2712
Score = 67.8 bits (164), Expect = 4e-11
Identities = 50/165 (30%), Positives = 72/165 (43%), Gaps = 13/165 (7%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 654
G + Y C GY L G C + +WS P C K C P I + S+ F
Sbjct: 3318 GPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLC-KPNPCPVPFVIPE-NALLSEKEFY 3375
Query: 655 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 714
V +V +C G+ L+G ++TC +T W+ KC + C P EN
Sbjct: 3376 VDQNVSIKCREGFLLQGHGIITCNPDET----WTQTSAKC--EKISCGPPAHVENAIARG 3429
Query: 715 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
HYQ G+ + + CY G+ L G + C+ WTS PP+C+
Sbjct: 3430 V--HYQYGDMITYSCYSGYMLEGFLRSVCLEN--GTWTS-PPICR 3469
Score = 67.4 bits (163), Expect = 5e-11
Identities = 124/583 (21%), Positives = 212/583 (36%), Gaps = 92/583 (15%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 277
+ C P +G ++ L TA++ CD+GY LQG + C W+ P+C
Sbjct: 1903 VKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECT--ASGIWDRAPPAC-- 1958
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVI--EAAEGRRLHLHFERVSLDEDN---D 332
H G + + G N T R + EG L LD D
Sbjct: 1959 ------HLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTL------AGLDTIECLAD 2006
Query: 333 RLMVRSGGSPLS-----PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLS---- 383
RS L+ P I D + R L D Y N LL
Sbjct: 2007 GKWSRSDQQCLAVSCDEPPIVDHASPETAHR-LFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
Query: 384 --LRFEAFEEDRCFA------PFLAHGNV-TTTDPEYRPGALATFSCLPGYALEPPGPPN 434
+ E + RC A P +++ + + + ++ G++ +F C+ G+ L
Sbjct: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSA--- 2122
Query: 435 AIECVDPTEPHWNDTEPACKAM---CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQE 491
IEC+ + WN + + + + CG S G ++ C G +++
Sbjct: 2123 KIECMRGGQ--WNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKG 2180
Query: 492 EKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLTLQFQ 547
EK+ + + P+ ++ P+ L + +++Q
Sbjct: 2181 EKKSTCEA----------TGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQ 2230
Query: 548 APPGPPNPGLGQGFVLHFKEVPRNDT--------CPELPPPEWGWRTASHGDLIRGTVLT 599
PG + G FV +++ C + PP + G+ + ++ G+ +
Sbjct: 2231 CNPGYKSVG-SPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEV--GSKVQ 2287
Query: 600 YQCEPGYELLGSDILTCQWDLSWS-AAPPACQKIMTCADPGEIANGHRTASDAGFPVGSH 658
+ C GYEL+G TCQ W+ + P C C +P + N + VG
Sbjct: 2288 FFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMP-AKCPEPPLLEN-QLVLKELTTEVGV- 2344
Query: 659 VQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKY---EPCLNPGVPENGYQTLY 715
V + C G+ L+G ++L C + +W+D P C + P ++ GVP +
Sbjct: 2345 VTFSCKEGHVLQGPSVLKCLP----SQQWNDSFPVCKIVLCTPPPLISFGVP------IP 2394
Query: 716 KHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 758
G ++++ C GF L G T C P W+S P C
Sbjct: 2395 SSALHFGSTVKYSCVGGFFLRGNSTTLCQP--DGTWSSPLPEC 2435
Score = 61.2 bits (147), Expect = 4e-09
Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 5/125 (4%)
Query: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 633
CP L PPE G+ + + +C PG++L+GS I+ C + WS + C ++
Sbjct: 378 CPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC-RVR 436
Query: 634 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 693
TC + +GH + S + C GY LEG+ LTC G +W P+
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPR 492
Query: 694 CALKY 698
C ++
Sbjct: 493 CVERH 497
Score = 57.0 bits (136), Expect = 7e-08
Identities = 42/182 (23%), Positives = 74/182 (40%), Gaps = 14/182 (7%)
Query: 578 PPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD 637
PP + + I G + YQC PGY+L G+ C + SWS + P+C C+
Sbjct: 2951 PPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLP-CRCST 3009
Query: 638 PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALK 697
P + T + F G + +C G+ L G + +TC +WS P C +
Sbjct: 3010 P---VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITC----EADGQWSSGFPHC--E 3060
Query: 698 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 757
+ C + + N + + + + + C G+ + G + C W+ P+
Sbjct: 3061 HTSCGSLPMIPNAF--ISETSSWKENVITYSCRSGYVIQGSSDLICT--EKGVWSQPYPV 3116
Query: 758 CK 759
C+
Sbjct: 3117 CE 3118
Score = 56.2 bits (134), Expect = 1e-07
Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 2/59 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
+SCG PP +G S D + G T T+ C++GY L G+ + C + SWNG +PSC+
Sbjct: 1688 ISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD--NGSWNGVSPSCL 1744
Score = 55.5 bits (132), Expect = 2e-07
Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 598 LTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGS 657
++ +C G+ L G I+TC D +W+ C+KI +C P + N A + G
Sbjct: 3380 VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKI-SCGPPAHVENA--IARGVHYQYGD 3436
Query: 658 HVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGV 706
+ Y C GY LEG C T T S + + ++ PC N G+
Sbjct: 3437 MITYSCYSGYMLEGFLRSVCLENGTWT---SPPICRAVCRF-PCQNGGI 3481
Score = 54.3 bits (129), Expect = 5e-07
Identities = 53/187 (28%), Positives = 71/187 (37%), Gaps = 20/187 (10%)
Query: 578 PPPEWGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPP----ACQKI 632
P PE HGD ++ C GY G +I CQ D +W PP +C +
Sbjct: 3182 PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCSPV 3239
Query: 633 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 692
+C P +G S F S + Y+C PGY LEG C +WS V
Sbjct: 3240 -SCGKPESPEHGFVVGSKYTFE--STIIYQCEPGYELEGNRERVCQE----NRQWSGGVA 3292
Query: 693 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 752
C K C P NG + + G ++ + C G+ L G C W+
Sbjct: 3293 IC--KETRCETPLEFLNGKADI--ENRTTGPNVVYSCNRGYSLEGPSEAHCTEN--GTWS 3346
Query: 753 SQPPLCK 759
PLCK
Sbjct: 3347 HPVPLCK 3353
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/128 (28%), Positives = 51/128 (39%), Gaps = 7/128 (5%)
Query: 573 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC--Q 630
TCP L P+ G + S +++ T C+ GY L GSD LTCQ + W P C +
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVER 496
Query: 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA-AMLTCYSRDTGTPKWSD 689
T P ++ G+ C G+ L G ML C T + KW+
Sbjct: 497 HCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRC----TTSGKWNV 552
Query: 690 RVPKCALK 697
V K
Sbjct: 553 GVQAAVCK 560
Score = 53.1 bits (126), Expect = 1e-06
Identities = 43/160 (26%), Positives = 63/160 (39%), Gaps = 12/160 (7%)
Query: 601 QCEPGYEL-LGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 659
+C GY + +D TCQ D W +C C P I H F V V
Sbjct: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSP-KKCPLPENIT--HILVHGDDFSVNRQV 3203
Query: 660 QYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHY 719
C GY+ EG + C T P +SD + C P PE+G+ K+ +
Sbjct: 3204 SVSCAEGYTFEGVNISVCQLDGTWEPPFSDE----SCSPVSCGKPESPEHGFVVGSKYTF 3259
Query: 720 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 759
++ ++ + C G+EL G C QW+ +CK
Sbjct: 3260 ES--TIIYQCEPGYELEGNRERVCQENR--QWSGGVAICK 3295
Score = 52.4 bits (124), Expect = 2e-06
Identities = 40/149 (26%), Positives = 60/149 (40%), Gaps = 14/149 (9%)
Query: 597 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVG 656
V+TY C GY + GS L C WS P C+ ++C P +AN A+
Sbjct: 3085 VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEP-LSCGSPPSVANA--VATGEAHTYE 3141
Query: 657 SHVQYRCLPGYSLE-GAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPEN-GYQTL 714
S V+ RCL GY+++ TC +W C+ K P +PEN + +
Sbjct: 3142 SEVKLRCLEGYTMDTDTDTFTCQK----DGRWFPERISCSPKKCP-----LPENITHILV 3192
Query: 715 YKHHYQAGESLRFFCYEGFELIGEVTITC 743
+ + + C EG+ G C
Sbjct: 3193 HGDDFSVNRQVSVSCAEGYTFEGVNISVC 3221
Score = 43.5 bits (101), Expect = 8e-04
Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 8/69 (11%)
Query: 694 CALKYEPCLNPGVPENGY--QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 751
C L + P L P PENGY Q +H+ A +R C+ GF+L+G I C+P W
Sbjct: 373 CELVHCPALKP--PENGYFIQNTCNNHFNAACGVR--CHPGFDLVGSSIILCLPN--GLW 426
Query: 752 TSQPPLCKV 760
+ C+V
Sbjct: 427 SGSESYCRV 435
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
++CG P AHG + GG + C GY+L G + CL + SW+G +PSC+
Sbjct: 2947 VNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCL--SNGSWSGSSPSCL 3003
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/64 (37%), Positives = 27/64 (42%), Gaps = 3/64 (4%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 277
+ C P P +G S G TF C GYQL G + CL WN P C A
Sbjct: 1787 IKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES--GEWNHLIPYCKA 1844
Query: 278 -SCG 280
SCG
Sbjct: 1845 VSCG 1848
Score = 40.0 bits (92), Expect = 0.009
Identities = 63/257 (24%), Positives = 86/257 (33%), Gaps = 77/257 (29%)
Query: 235 DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG------GTIHNA- 286
DL PG CD G+QL G CLN + W P C SCG H+A
Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCGVPPPLENGFHSAD 1704
Query: 287 -----------------TLG--RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 327
LG R+ + G G + +C V E A G H +++
Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNV 1764
Query: 328 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFE 387
D GS + + P G D ++ + + P NP
Sbjct: 1765 D-----------GSYICSCV-------PPYTG---DGKNCAEPIKCKAPGNP-------- 1795
Query: 388 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 447
N ++ Y GA TFSC GY L I C++ E WN
Sbjct: 1796 --------------ENGHSSGEIYTVGAEVTFSCQEGYQLM---GVTKITCLESGE--WN 1836
Query: 448 DTEPACKAMCGGELSEP 464
P CKA+ G+ + P
Sbjct: 1837 HLIPYCKAVSCGKPAIP 1853
Score = 39.3 bits (90), Expect = 0.016
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
+SCG P P +G + G T+ C+ GY L G++ CL SW+ P C
Sbjct: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL--ANSSWSHSPPVC 1900
Score = 38.5 bits (88), Expect = 0.027
Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
+SCG P P HG V + T + C+ GY+L+G +C + W+G C
Sbjct: 3239 VSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ--WSGGVAIC 3294
Score = 37.0 bits (84), Expect = 0.078
Identities = 18/60 (30%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 219 SCGFPPRPAHGDVSVT--DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
+C +P HG +S + ++ T CD GY+L+G + L C ++ W+G P C+
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
Score = 36.6 bits (83), Expect = 0.10
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 6/80 (7%)
Query: 205 RGGGFR---IHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL 261
RGG + + Q + CG PP +G S ++ G + C+ G+ ++GE+ C
Sbjct: 2128 RGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTC- 2186
Query: 262 NGTRPSWNGETPSC-MASCG 280
W+ P+C SCG
Sbjct: 2187 -EATGQWSSPIPTCHPVSCG 2205
Score = 36.6 bits (83), Expect = 0.10
Identities = 22/63 (34%), Positives = 28/63 (44%), Gaps = 3/63 (4%)
Query: 219 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MA 277
SCG P + +S T T+ C SGY +QG LIC + W+ P C
Sbjct: 3063 SCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTE--KGVWSQPYPVCEPL 3120
Query: 278 SCG 280
SCG
Sbjct: 3121 SCG 3123
Score = 35.4 bits (80), Expect = 0.23
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 216 YLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
+L+ CG PP ++ + T T+ C GY L G +T+ CL + W+ C
Sbjct: 1959 HLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK--WSRSDQQC 2016
Query: 276 MA-SC 279
+A SC
Sbjct: 2017 LAVSC 2021
Score = 33.1 bits (74), Expect = 1.1
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 217 LLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPS 274
++ C PP + G + + LH G T + C G+ L+G T +C +GT W+ P
Sbjct: 2378 IVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGT---WSSPLPE 2434
Query: 275 CM 276
C+
Sbjct: 2435 CV 2436
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 5/63 (7%)
Query: 218 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276
+SCG P + G T+ C SGY L+G +CL NGT W P C
Sbjct: 3414 ISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT---WT-SPPICR 3469
Query: 277 ASC 279
A C
Sbjct: 3470 AVC 3472
Score = 30.8 bits (68), Expect = 5.6
Identities = 19/70 (27%), Positives = 26/70 (37%), Gaps = 2/70 (2%)
Query: 210 RIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTR--PS 267
R Q +SC PP H G A ++C GY L L+C + P
Sbjct: 2011 RSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPP 2070
Query: 268 WNGETPSCMA 277
+ P C+A
Sbjct: 2071 EGQDMPRCIA 2080
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)
Query: 595 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 652
GTV+ Y+C PGY E S LTC +L WS A C+K +C +PGEI NG G
Sbjct: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
Query: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712
G+ + + C GY L G+ C + +WSD +P+C Y C P +NG
Sbjct: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
+ HY +S+ + C +GF +IGE +I C V +W+ PP C+
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 67.0 bits (162), Expect = 7e-11
Identities = 53/175 (30%), Positives = 75/175 (42%), Gaps = 17/175 (9%)
Query: 596 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 650
TV+TY+CE + + D + C WS C + +C P + + +
Sbjct: 59 TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
Query: 651 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
FPVG+ V+Y C PGY E + LTC KWS V C K + C NPG
Sbjct: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVAY 762
NG Q G ++ F C G++L G + C + G QW+ P C+ Y
Sbjct: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY 224
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 590 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 646
G ++ G +++ C GY+L GS C + WS P C++I C P +I NG
Sbjct: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
Query: 647 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 694
+ V Y C G+++ G + C + D G +WS P+C
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 219 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 272
SC P +G + V PGG T +F C++GY+L G + CL +G+ W+
Sbjct: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
Query: 273 PSC 275
P C
Sbjct: 218 PEC 220
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)
Query: 595 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 652
GTV+ Y+C PGY E S LTC +L WS A C+K +C +PGEI NG G
Sbjct: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
Query: 653 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 712
G+ + + C GY L G+ C + +WSD +P+C Y C P +NG
Sbjct: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
Query: 713 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
+ HY +S+ + C +GF +IGE +I C V +W+ PP C+
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 67.0 bits (162), Expect = 7e-11
Identities = 53/175 (30%), Positives = 75/175 (42%), Gaps = 17/175 (9%)
Query: 596 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 650
TV+TY+CE + + D + C WS C + +C P + + +
Sbjct: 59 TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
Query: 651 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 708
FPVG+ V+Y C PGY E + LTC KWS V C K + C NPG
Sbjct: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVAY 762
NG Q G ++ F C G++L G + C + G QW+ P C+ Y
Sbjct: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY 224
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 590 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 646
G ++ G +++ C GY+L GS C + WS P C++I C P +I NG
Sbjct: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
Query: 647 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 694
+ V Y C G+++ G + C + D G +WS P+C
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 219 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 272
SC P +G + V PGG T +F C++GY+L G + CL +G+ W+
Sbjct: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
Query: 273 PSC 275
P C
Sbjct: 218 PEC 220
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 91.7 bits (226), Expect = 3e-18
Identities = 91/359 (25%), Positives = 141/359 (39%), Gaps = 26/359 (7%)
Query: 419 FSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYS 478
+SC GY L G +A + W++ P C + G A + + +
Sbjct: 121 YSCPKGYRLI--GSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
Query: 479 PGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRR 534
G C G ++ ++ + I + D + ++ G P + + P
Sbjct: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
Query: 535 LL-SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP--------PPE--WG 583
+L S L + PG G H K N PELP PP+
Sbjct: 239 ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHA 298
Query: 584 WRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEI 641
RT D G + Y CEPGY+L GS L C WS A P C+ + +C D G++
Sbjct: 299 ERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCE-VKSCDDFLGQL 357
Query: 642 ANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPC 701
NGH +G+ V + C G+ L+G++ C + W+ VP C K C
Sbjct: 358 PNGH-VLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCERK--SC 413
Query: 702 LNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 759
P VP NG + G + + C G LIG + C+ G+ + W+ +PP+C+
Sbjct: 414 ETPPVPVNGMVHVIT-DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQ 471
Score = 69.3 bits (168), Expect = 1e-11
Identities = 118/519 (22%), Positives = 182/519 (35%), Gaps = 111/519 (21%)
Query: 219 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 276
SC PP P +G V D+ + C GY+L G + C+ +G W+ +TP C
Sbjct: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC- 153
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMV 336
RI+ P + T R + H+ V N +
Sbjct: 154 ------------DRIICGLPPTIANGDFTSI--------SREYFHYGSVVTYHCN----L 189
Query: 337 RSGGSPL-----SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 391
S G + P IY + DD + G+ S PA ++
Sbjct: 190 GSRGKKVFELVGEPSIYCTSKDD--QVGIWSG------------PAPQCIIP-------- 227
Query: 392 DRCFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 450
++C P + +G + + + + + F C PG+ ++ P + ++C + W
Sbjct: 228 NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP---SHVKCQALNK--WEPEL 282
Query: 451 PACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQVEILNVRE 506
P+C +C +P VL + Q ++SPGQ+ + + R + +
Sbjct: 283 PSCSRVC-----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC--TPQ 335
Query: 507 GDMLTL-----------FDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNP 555
GD F G P+ VL L L G + F G
Sbjct: 336 GDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLN--------LQLGAKV--DFVCDEGFQLK 385
Query: 556 GLGQGF-VLHFKEVPRNDTCP-------ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYE 607
G + VL E N + P E PP D+ G+ + Y C G+
Sbjct: 386 GSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHR 445
Query: 608 LLGSDILTCQWD---LSWSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRC 663
L+G C WS PP CQ+I C +P I NG T + G P G V Y C
Sbjct: 446 LIGHSSAECILSGNTAHWSMKPPICQQIF-CPNPPAILNGRHTGTPLGDIPYGKEVSYTC 504
Query: 664 LP------GYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL 696
P ++L G + + S G WS P+C L
Sbjct: 505 DPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
Score = 67.0 bits (162), Expect = 7e-11
Identities = 60/220 (27%), Positives = 84/220 (38%), Gaps = 15/220 (6%)
Query: 566 KEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD---LSW 622
K+ + +C P P G R + Y C GY L+GS TC + W
Sbjct: 88 KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQI-KYSCPKGYRLIGSSSATCIISGNTVIW 146
Query: 623 SAAPPACQKIMTCADPGEIANGHRTA-SDAGFPVGSHVQYRCLPG------YSLEGAAML 675
P C +I+ C P IANG T+ S F GS V Y C G + L G +
Sbjct: 147 DNKTPVCDRII-CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205
Query: 676 TCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 735
C S+D WS P+C + C P V + + + E + F C GF +
Sbjct: 206 YCTSKDDQVGIWSGPAPQCIIP-NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGM 264
Query: 736 IGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQ 775
G + C ++W + P C + D E TQ
Sbjct: 265 KGPSHVKCQA--LNKWEPELPSCSRVCQPPPDVLHAERTQ 302
Score = 63.9 bits (154), Expect = 6e-10
Identities = 47/173 (27%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 595 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG-HRTASDAGF 653
GT L Y+C PGY I+ C + W++A C++ +C +P + NG D F
Sbjct: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKR-KSCRNPPDPVNGMAHVIKDIQF 115
Query: 654 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 713
S ++Y C GY L G++ TC T W ++ P C + L P + + +
Sbjct: 116 --RSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTPVCD-RIICGLPPTIANGDFTS 171
Query: 714 LYKHHYQAGESLRFFCYEG------FELIGEVTITCV--PGHPSQWTSQPPLC 758
+ + ++ G + + C G FEL+GE +I C W+ P C
Sbjct: 172 ISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC 224
Score = 58.9 bits (141), Expect = 2e-08
Identities = 34/110 (30%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 650 DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPEN 709
D FP+G+++ Y C PGYS +++ C W+ KC K + C NP P N
Sbjct: 52 DFEFPIGTYLNYECRPGYSGRPFSII-CLKNSV----WTSAKDKC--KRKSCRNPPDPVN 104
Query: 710 GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLC 758
G + K Q +++ C +G+ LIG + TC + G+ W ++ P+C
Sbjct: 105 GMAHVIK-DIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 89.4 bits (220), Expect = 1e-17
Identities = 142/592 (23%), Positives = 215/592 (36%), Gaps = 110/592 (18%)
Query: 216 YLLSCGFPPRPAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWN 269
Y+ CG P H V + HP G +FHC GYQ+ G L CL W
Sbjct: 196 YVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWT 251
Query: 270 GETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 329
+ P C+A A + PE G N+TC LH + +
Sbjct: 252 NKPPQCLA--------AQCPPLKIPERG-----NMTC-------------LHSAKAFQHQ 285
Query: 330 DNDRLMVRSGGSPLSPVIYDSDMDDV--PERGLISDAQSLYVELLSETPANPLLLSLRFE 387
+ G + + P + V + Q ++E SE +
Sbjct: 286 SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD--------- 336
Query: 388 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 447
C P A + G+ F C PGY + + + C+D HW+
Sbjct: 337 ------CVHPLTA----------FAYGSSCKFECQPGYRVR---GLDMLRCID--SGHWS 375
Query: 448 DTEPACKAMCGGELSEP--AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 505
P C+A+ L P + SP +++ +C + E +L +I+
Sbjct: 376 APLPTCEAISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRC---AEGFMLRGADIVRC- 430
Query: 506 EGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPG-PPNPGL---GQG 560
D L + P + L P P R+ S P ++Q+ N GL G
Sbjct: 431 --DNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGAS 488
Query: 561 FVL-----HFKEVP---RNDTCPELPPPEWGWRTASH--GDLIRGTVLTYQCEPGYELLG 610
+ ++ VP + C L P+ G T G + + C+ GY L G
Sbjct: 489 VLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG 548
Query: 611 SDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYS 668
+ L C W+ +PP C+ I C + G SD F VGS + C G+
Sbjct: 549 PERLDCTRSGRWTDSPPMCEAI-KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
Query: 669 LEGAAMLTCYSRDTGTPKWSDRVPKC----ALKYEPCLNPGVPENGYQTLY-KHH---YQ 720
LEG + C T + +WS P C +L P + G T+Y +HH +
Sbjct: 608 LEGPNNVEC----TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFG 663
Query: 721 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK-VAYEELLDNRKL 771
+ F C GF LIG+ T++C P QWT+ P C+ V EL N+ +
Sbjct: 664 FNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRAVKCSELHVNKPI 713
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/198 (26%), Positives = 78/198 (39%), Gaps = 19/198 (9%)
Query: 574 CPELPPPEWGWRTAS--HGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 631
CPEL PE G S G+ G+ + C+ G++L G + + C WSA PP C+
Sbjct: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
Query: 632 IMTCADPGEIANGHRTASD---------AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDT 682
I + PG T F + + C G++L G + L+C R +
Sbjct: 632 IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC--RPS 689
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 742
G +W+ P C L+ P + ++ G F C EG L G
Sbjct: 690 G--QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTA 747
Query: 743 CVP-GHPSQWTSQPPLCK 759
C GH W++ P C+
Sbjct: 748 CQENGH---WSTTVPTCQ 762
Score = 46.6 bits (109), Expect = 1e-04
Identities = 87/420 (20%), Positives = 124/420 (29%), Gaps = 124/420 (29%)
Query: 226 PAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 279
P + V HP G +F C+ G L G L CL +WN P C A
Sbjct: 452 PVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWNSVPPECQAIP 509
Query: 280 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 339
+ + G + +P G+ TC+++ + E SL RSG
Sbjct: 510 CTPLLSPQNGTMTCVQPLGSSSYKSTCQFICD-----------EGYSLSGPERLDCTRSG 558
Query: 340 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL 399
SP + EA + FAP
Sbjct: 559 RWTDSPPMC--------------------------------------EAIKCPELFAPEQ 580
Query: 400 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM--- 456
+ + T E+ G+ FSC G+ LE PN +EC T W+ T P CK +
Sbjct: 581 GSLDCSDTRGEFNVGSTCHFSCDNGFKLE---GPNNVECT--TSGRWSATPPTCKGIASL 635
Query: 457 ------CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDML 510
C + G + P ++ C +G +
Sbjct: 636 PTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAG-------------------F 676
Query: 511 TLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPR 570
TL S R Q P R + LH + P
Sbjct: 677 TLIGDSTLSCRPSGQWTAVTPACRAVKCSE----------------------LHVNK-PI 713
Query: 571 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630
C L WG + G++ ++ C G L GS CQ + WS P CQ
Sbjct: 714 AMNCSNL----WG-------NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 82.4 bits (202), Expect = 2e-15
Identities = 79/267 (29%), Positives = 116/267 (43%), Gaps = 35/267 (13%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEG--GNLALAILLPLG 797
TI C S T PP+ K K + + + EG +L + ++ +
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIV 322
Query: 798 LVIVLGSGV-------YIYYTKLQGKS 817
+ IV+G V Y+ K +GK+
Sbjct: 323 IAIVVGVAVICVVPYRYLQRRKKKGKA 349
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 35.8 bits (81), Expect = 0.17
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-ASCGGTIHNATLGRIVSPEPGGA 299
T F CD G+ L G +T++C + +W+ P C+ S T + P+P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEG 308
Query: 300 VGPNLTCRWVI 310
+ +L WVI
Sbjct: 309 ILDSLDV-WVI 318
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 81.6 bits (200), Expect = 3e-15
Identities = 70/213 (32%), Positives = 95/213 (44%), Gaps = 28/213 (13%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLCKVAY----EELLDN 768
TI C S W P C Y E +LD+
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKGYPKPEEGILDS 297
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.39
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 81.6 bits (200), Expect = 3e-15
Identities = 70/213 (32%), Positives = 95/213 (44%), Gaps = 28/213 (13%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLCKVAY----EELLDN 768
TI C S W P C Y E +LD+
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKGYPKPEEGILDS 297
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.39
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 81.3 bits (199), Expect = 4e-15
Identities = 75/249 (30%), Positives = 109/249 (43%), Gaps = 28/249 (11%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEG--GNLALAILLPLG 797
TI C S T PP+ K K + + + EG +L + ++ +
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIV 322
Query: 798 LVIVLGSGV 806
+ IV+G V
Sbjct: 323 IAIVVGVAV 331
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 35.8 bits (81), Expect = 0.17
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-ASCGGTIHNATLGRIVSPEPGGA 299
T F CD G+ L G +T++C + +W+ P C+ S T + P+P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEG 308
Query: 300 VGPNLTCRWVI 310
+ +L WVI
Sbjct: 309 ILDSLDV-WVI 318
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 80.5 bits (197), Expect = 6e-15
Identities = 96/455 (21%), Positives = 171/455 (37%), Gaps = 59/455 (12%)
Query: 103 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLV- 161
C ++++ G ++SP+ + +C + I V G+ + + Q + + +
Sbjct: 464 CGGDMNKDAGQIQSPNYPDDYRPSK---ECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520
Query: 162 -LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSC 220
L P L+ + + + ++S +NRL + F S GF ++ + C
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580
Query: 221 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 280
+P HG ++ G+ CD GY+L ++ + C +CG
Sbjct: 581 SWPD---HGGCEHRCVNTLGSYKCACDPGYELAADKKM----------------CEVACG 621
Query: 281 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMV 336
G I G I SP N C W + A R+ L FE L+ ++ D + V
Sbjct: 622 GFITKLN-GTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEV 680
Query: 337 RSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 396
RSG SP + + + PE + S + ++ VE S+ + F + ++D C
Sbjct: 681 RSGLSPDAKLHGRFCGSETPE-VITSQSNNMRVEFKSDNTVSKRGFRAHFFS-DKDEC-- 736
Query: 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 456
A N C GY L N +C + A
Sbjct: 737 ---AKDNGGCQHECVNTFGSYLCRCRNGYWLH----ENGHDCKE--------------AG 775
Query: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLT 511
C ++S G + SP+WP Y ++C W + R+ L + + D L
Sbjct: 776 CAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLE 835
Query: 512 LFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQF 546
++DG A +L + G + ++SG + L+F
Sbjct: 836 MYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRF 870
Score = 78.2 bits (191), Expect = 3e-14
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 45/301 (14%)
Query: 277 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----D 332
A+CGG + N G+I SP P+ C W I +EG + L F+ ++ + D
Sbjct: 462 ATCGGDM-NKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520
Query: 333 RLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEED 392
L VR G + S +I + PE + S + L+++ +S+ N + F E D
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPE-DVKSSSNRLWMKFVSDGSINKAGFAANFFK-EVD 578
Query: 393 RCFAPFLAHGNVTTTDPEYR-PGALATFSCL--PGYALEPPGPPNAIECVDPTEPHWNDT 449
C P HG E+R L ++ C PGY L
Sbjct: 579 ECSWP--DHGGC-----EHRCVNTLGSYKCACDPGYELAAD------------------- 612
Query: 450 EPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL-----NV 504
+ C+ CGG +++ G + SP WP+ Y ++CVW V + RI LQ E+ +V
Sbjct: 613 KKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDV 672
Query: 505 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 564
+ D + + G P A++ + G + + S ++ ++F++ N +GF H
Sbjct: 673 CKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKS----DNTVSKRGFRAH 728
Query: 565 F 565
F
Sbjct: 729 F 729
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/167 (27%), Positives = 70/167 (41%), Gaps = 26/167 (15%)
Query: 452 ACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG---- 507
A +A CGG++++ AG + SP++P Y P ++CVW + V E + L + +
Sbjct: 459 AYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCA 518
Query: 508 -DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 566
D L + DG + ++ G + + SS L ++F + G F FK
Sbjct: 519 YDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF---FK 575
Query: 567 EVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY-----QCEPGYEL 608
EV D C W HG V T C+PGYEL
Sbjct: 576 EV---DEC------SW----PDHGGCEHRCVNTLGSYKCACDPGYEL 609
Score = 38.5 bits (88), Expect = 0.027
Identities = 54/254 (21%), Positives = 90/254 (35%), Gaps = 31/254 (12%)
Query: 101 VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 160
V C I++ G + SP G P +C + + Y I +Q + L +
Sbjct: 618 VACGGFITKLNGTITSP--GWPKEYPTNK-NCVWQVVAPAQYRISLQFEVFELEGNDVCK 674
Query: 161 VLAGGGSPGLAPRLLANSSMLGEG--QVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL 218
GL+P + G +V+ S +N + + F+S GFR H+ +
Sbjct: 675 YDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKD 734
Query: 219 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-A 277
C +G ++ G+ C +GY L NG C A
Sbjct: 735 ECA----KDNGGCQHECVNTFGSYLCRCRNGYWLHE--------------NGH--DCKEA 774
Query: 278 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DR 333
C I ++ G + SP C W I + G R+ L F +++ D
Sbjct: 775 GCAHKI-SSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDH 833
Query: 334 LMVRSGGSPLSPVI 347
L + G L+P++
Sbjct: 834 LEMYDGPDSLAPIL 847
Score = 37.4 bits (85), Expect = 0.059
Identities = 27/110 (24%), Positives = 50/110 (45%), Gaps = 9/110 (8%)
Query: 457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLT 511
CG L + G +P +P Y CVW + V ++I+L +++ + D +
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 512 LFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGF 561
+ DG A +L + G + L+S+ L ++F++ LG+GF
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNI----LGKGF 456
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLC 758
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.6 bits (83), Expect = 0.10
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 646
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.30
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 296
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLC 758
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.6 bits (83), Expect = 0.10
Identities = 19/70 (27%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 651
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 652 GFPVGSHVQY 661
P S Y
Sbjct: 308 KSPASSASGY 317
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.39
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLC 758
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.39
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Score = 32.0 bits (71), Expect = 2.5
Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 631
+ TV+ ++C+ G+ L GSD + C + +W P C K
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLC 758
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.39
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Score = 32.0 bits (71), Expect = 2.5
Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 631
+ TV+ ++C+ G+ L GSD + C + +W P C K
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLC 758
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.6 bits (83), Expect = 0.10
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 646
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.30
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 296
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 572 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 628
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 629 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 682
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 739
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 740 TITCVPGHPSQWTSQPPLC 758
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 653 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 708
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 709 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 759
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 244 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 275
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.39
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 241 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 276
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Score = 32.0 bits (71), Expect = 2.5
Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 594 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 631
+ TV+ ++C+ G+ L GSD + C + +W P C K
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.138 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,605,207
Number of Sequences: 37866
Number of extensions: 2630201
Number of successful extensions: 10657
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 73
Number of HSP's that attempted gapping in prelim test: 7751
Number of HSP's gapped (non-prelim): 1598
length of query: 853
length of database: 18,247,518
effective HSP length: 111
effective length of query: 742
effective length of database: 14,044,392
effective search space: 10420938864
effective search space used: 10420938864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.