Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 6912466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912466 F-box and leucine-rich repeat protein 7 [Homo
sapiens]
(491 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 1002 0.0
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 181 2e-45
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 171 1e-42
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 135 1e-31
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 121 1e-27
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 121 1e-27
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 107 2e-23
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 95 2e-19
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 89 9e-18
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 83 5e-16
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H... 81 2e-15
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H... 76 6e-14
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 75 1e-13
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 75 1e-13
gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] 73 5e-13
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 69 7e-12
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 68 2e-11
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 66 6e-11
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 65 1e-10
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 65 1e-10
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 62 1e-09
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 62 1e-09
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 50 4e-06
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 50 4e-06
gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens] 50 4e-06
gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens] 50 4e-06
gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens] 50 4e-06
gi|27312027 F-box only protein 16 [Homo sapiens] 43 6e-04
gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [H... 42 0.001
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 41 0.003
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 1002 bits (2590), Expect = 0.0
Identities = 491/491 (100%), Positives = 491/491 (100%)
Query: 1 MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALIC 60
MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALIC
Sbjct: 1 MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALIC 60
Query: 61 PPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDH 120
PPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDH
Sbjct: 61 PPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDH 120
Query: 121 SMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQD 180
SMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQD
Sbjct: 121 SMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQD 180
Query: 181 TPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNL 240
TPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNL
Sbjct: 181 TPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNL 240
Query: 241 EHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQL 300
EHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQL
Sbjct: 241 EHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQL 300
Query: 301 THLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHC 360
THLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHC
Sbjct: 301 THLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHC 360
Query: 361 GRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGL 420
GRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGL
Sbjct: 361 GRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGL 420
Query: 421 ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKR 480
ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKR
Sbjct: 421 ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKR 480
Query: 481 CVIEHTNPAFF 491
CVIEHTNPAFF
Sbjct: 481 CVIEHTNPAFF 491
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 181 bits (458), Expect = 2e-45
Identities = 109/372 (29%), Positives = 190/372 (51%), Gaps = 26/372 (6%)
Query: 116 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-RALKVLT 174
+LP +++IFSFL LCRCA++ + W LA D W+ I L I+V+ R ++ ++
Sbjct: 14 KLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENIS 73
Query: 175 RRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVV 234
+R C L +++ GC + D L T AQ C + L ++GC I++ + +
Sbjct: 74 KR-CGG------FLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLS 126
Query: 235 SLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQIS-----IRYLDMTDCFVLEDEG 289
C L+HLD++ C +T SL K IS + YL+++ C + +G
Sbjct: 127 RFCSKLKHLDLTSCVSITNSSL-------------KGISEGCRNLEYLNLSWCDQITKDG 173
Query: 290 LHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLE 349
+ + C L L LR C +L DE L+++ YC + L++ C ++D G+ +I +
Sbjct: 174 IEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGC 233
Query: 350 SRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDI 409
RL+ L ++ C +TD + + C +L+ L A C +TD G LA+NC +L+ +D+
Sbjct: 234 HRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDL 293
Query: 410 GKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVE 469
+C L++D+ L L+++C L+ LSL CE IT G+ ++ + + L V + + +
Sbjct: 294 EECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLL 353
Query: 470 ALRFVKRHCKRC 481
H + C
Sbjct: 354 ITDVALEHLENC 365
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 171 bits (434), Expect = 1e-42
Identities = 108/370 (29%), Positives = 190/370 (51%), Gaps = 22/370 (5%)
Query: 116 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-RALKVLT 174
+LP +++IFSFL LCRCA+V R W LA D W+ I L +++ R ++ ++
Sbjct: 27 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENIS 86
Query: 175 RRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVV 234
+R C L +++ GC + D L T AQ C + L ++GC ++ +
Sbjct: 87 KR-CGG------FLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLS 139
Query: 235 SLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIA 294
C L HLD++ C+ +T +SL +A + PL + L+++ C + +G+ +
Sbjct: 140 KFCSKLRHLDLASCTSITNMSL--KALSEGCPL------LEQLNISWCDQVTKDGIQALV 191
Query: 295 AHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRY 354
C L L+L+ C +L DE L+Y+ +C + L++ C ++D GL I + +L+
Sbjct: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251
Query: 355 LSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPL 414
L + C +TD + + + C +LR L C +TD G LA+NC +L+ +D+ +C
Sbjct: 252 LCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQ 311
Query: 415 VSDTGLECLALNCFNLKRLSLKSCESITGQGLQIV---AANCFDLQTLNVQDCEVSVEAL 471
++D+ L L+++C L+ LSL CE IT G++ + A L+ + + +C + +A
Sbjct: 312 ITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDA- 370
Query: 472 RFVKRHCKRC 481
H K C
Sbjct: 371 --SLEHLKSC 378
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 135 bits (339), Expect = 1e-31
Identities = 103/369 (27%), Positives = 176/369 (47%), Gaps = 40/369 (10%)
Query: 122 MVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDT 181
+ IF +L R A+VC W + A+ +WR + K+ RR
Sbjct: 13 LAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEA-----------KLHLRRA---N 58
Query: 182 PNVCLMLETVTVSGCRRLT----DRGLYTIAQCCPELRRLEVSGCYNISNEAVFDV-VSL 236
P+ + ++ G RR+ R L + Q + L +SGCYN+++ + V
Sbjct: 59 PS---LFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQE 115
Query: 237 CPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAH 296
+L L++S C ++T SL R A L G ++ L++ C + + GL IA
Sbjct: 116 IGSLRALNLSLCKQITDSSLGRIAQY----LKGLEV----LELGGCSNITNTGLLLIAWG 167
Query: 297 CTQLTHLYLRRCVRLTDEGLRYLVIY-------CASIKELSVSDCRFVSDFGLREIAKLE 349
+L L LR C L+D G+ +L C +++L++ DC+ ++D L+ I++
Sbjct: 168 LQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGL 227
Query: 350 SRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDI 409
+ LR L+++ CG ++D G+ +++ + LR LN R C+ I+D G+ +LA +L LD+
Sbjct: 228 TGLRLLNLSFCGGISDAGLLHLS-HMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDV 286
Query: 410 GKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDC-EVSV 468
C V D L +A LK LSL SC I+ G+ + L+TLN+ C ++
Sbjct: 287 SFCDKVGDQSLAYIAQGLDGLKSLSLCSCH-ISDDGINRMVRQMHGLRTLNIGQCVRITD 345
Query: 469 EALRFVKRH 477
+ L + H
Sbjct: 346 KGLELIAEH 354
Score = 92.0 bits (227), Expect = 1e-18
Identities = 68/247 (27%), Positives = 119/247 (48%), Gaps = 26/247 (10%)
Query: 188 LETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSL-------CPNL 240
LE + + GC +T+ GL IA L+ L + C ++S+ + + + C L
Sbjct: 145 LEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGL 204
Query: 241 EHLDVSGCSKVTCISL-------TREASIKLS---------PLHGKQI-SIRYLDMTDCF 283
E L + C K+T +SL T + LS LH + S+R L++ C
Sbjct: 205 EQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCD 264
Query: 284 VLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLR 343
+ D G+ +A +L+ L + C ++ D+ L Y+ +K LS+ C +SD G+
Sbjct: 265 NISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCH-ISDDGIN 323
Query: 344 EIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAK-NCT 402
+ + LR L+I C R+TD G+ +A++ S+L ++ GC IT G+E + + C
Sbjct: 324 RMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCL 383
Query: 403 KLKSLDI 409
K+ +L +
Sbjct: 384 KVLNLGL 390
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 121 bits (304), Expect = 1e-27
Identities = 103/419 (24%), Positives = 179/419 (42%), Gaps = 65/419 (15%)
Query: 111 QASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTG-ETINVDRA 169
+ I LP+ +++QIF +L + C +V W + LW I + + + D+
Sbjct: 152 KCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY 211
Query: 170 LKV-----------LTRRLCQDTPNV------CLMLETVTVSGCRRLTDRGLYTIAQCCP 212
+ L R C P C L+ + VS C TD + I++ CP
Sbjct: 212 IVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCP 271
Query: 213 ELRRLEVSGCYNISNEAVFD-VVSLCP----NLEHLDVSGCSKVTCISLTREASIKLSPL 267
+ C N+SN + + + L P NL++L ++ C + T + ++ L
Sbjct: 272 GVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFT------DKGLQYLNL 319
Query: 268 HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIK 327
+ YLD++ C + +G IA CT + HL + LTD ++ LV C+ I
Sbjct: 320 GNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379
Query: 328 ELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCE 387
L + +SD R ++ +LR + RVTD +++ K L ++ C+
Sbjct: 380 SLVFTGAPHISDCTFRALS--ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCK 437
Query: 388 GITDHGVEYLA----------KNCT-----------------KLKSLDIGKCPLVSDTGL 420
GITD + L+ NC +++ L++ C +SD +
Sbjct: 438 GITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASV 497
Query: 421 ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCK 479
L+ C NL LSL++CE +T QG+ + N F L ++++ ++S E L + RH K
Sbjct: 498 MKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDLSGTDISNEGLNVLSRHKK 555
Score = 111 bits (278), Expect = 1e-24
Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 37/322 (11%)
Query: 173 LTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLY--TIAQCCPELRRLEVSGCYNISNEAV 230
+T R + P L+ ++++ CRR TD+GL + C +L L++SGC IS +
Sbjct: 283 ITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGF 342
Query: 231 FDVVSLCPNLEHLDVSGCSKVT--CISLTREASIKLSPL------HGKQISIRYLDMTDC 282
+ + C + HL ++ +T C+ E +++ L H + R L
Sbjct: 343 RYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKL 402
Query: 283 FVLEDEG--------LHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSV--- 331
+ EG I + L+H+Y+ C +TD LR L + +K+L+V
Sbjct: 403 RKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL----SPLKQLTVLNL 458
Query: 332 SDCRFVSDFGLREI--AKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGI 389
++C + D GL++ R+R L++++C R++D + +++ C L YL+ R CE +
Sbjct: 459 ANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHL 518
Query: 390 TDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQI- 448
T G+ Y+ N L S+D+ +S+ GL L+ + LK LS+ C IT G+QI
Sbjct: 519 TAQGIGYIV-NIFSLVSIDLSGTD-ISNEGLNVLSRH-KKLKELSVSECYRITDDGIQIT 575
Query: 449 ------VAANCFDLQTLNVQDC 464
++A C L L++ C
Sbjct: 576 DSAMEMLSAKCHYLHILDISGC 597
Score = 35.4 bits (80), Expect = 0.12
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 17/113 (15%)
Query: 156 TIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYT-------IA 208
+I L+G I+ + L VL+R L+ ++VS C R+TD G+ ++
Sbjct: 534 SIDLSGTDIS-NEGLNVLSRHK---------KLKELSVSECYRITDDGIQITDSAMEMLS 583
Query: 209 QCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREAS 261
C L L++SGC ++++ + D+ C L L + C+ ++ + R +S
Sbjct: 584 AKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSS 636
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 121 bits (304), Expect = 1e-27
Identities = 103/419 (24%), Positives = 179/419 (42%), Gaps = 65/419 (15%)
Query: 111 QASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTG-ETINVDRA 169
+ I LP+ +++QIF +L + C +V W + LW I + + + D+
Sbjct: 152 KCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY 211
Query: 170 LKV-----------LTRRLCQDTPNV------CLMLETVTVSGCRRLTDRGLYTIAQCCP 212
+ L R C P C L+ + VS C TD + I++ CP
Sbjct: 212 IVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCP 271
Query: 213 ELRRLEVSGCYNISNEAVFD-VVSLCP----NLEHLDVSGCSKVTCISLTREASIKLSPL 267
+ C N+SN + + + L P NL++L ++ C + T + ++ L
Sbjct: 272 GVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFT------DKGLQYLNL 319
Query: 268 HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIK 327
+ YLD++ C + +G IA CT + HL + LTD ++ LV C+ I
Sbjct: 320 GNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379
Query: 328 ELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCE 387
L + +SD R ++ +LR + RVTD +++ K L ++ C+
Sbjct: 380 SLVFTGAPHISDCTFRALS--ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCK 437
Query: 388 GITDHGVEYLA----------KNCT-----------------KLKSLDIGKCPLVSDTGL 420
GITD + L+ NC +++ L++ C +SD +
Sbjct: 438 GITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASV 497
Query: 421 ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCK 479
L+ C NL LSL++CE +T QG+ + N F L ++++ ++S E L + RH K
Sbjct: 498 MKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDLSGTDISNEGLNVLSRHKK 555
Score = 120 bits (300), Expect = 4e-27
Identities = 86/323 (26%), Positives = 152/323 (47%), Gaps = 42/323 (13%)
Query: 183 NVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEH 242
N C L + +SGC +++ +G IA C + L ++ +++ V +V C +
Sbjct: 321 NGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITS 380
Query: 243 LDVSGCSKVTCISLTREASIKLSPLH---GKQI---SIRYLD----------MTDCFVLE 286
L +G ++ + ++ KL + K++ S +++D M DC +
Sbjct: 381 LVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGIT 440
Query: 287 DEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCAS--IKELSVSDCRFVSDFGLRE 344
D L +++ QLT L L CVR+ D GL+ + AS I+EL++S+C +SD + +
Sbjct: 441 DSSLRSLSP-LKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMK 499
Query: 345 IAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS-----------------------KLRYL 381
+++ L YLS+ +C +T GI Y+ S KL+ L
Sbjct: 500 LSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKEL 559
Query: 382 NARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESI 441
+ C ITD G++ K+ L+ LD+ C +SD ++ LA+ C NL LS+ C I
Sbjct: 560 SVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKI 619
Query: 442 TGQGLQIVAANCFDLQTLNVQDC 464
T +++++A C L L++ C
Sbjct: 620 TDSAMEMLSAKCHYLHILDISGC 642
Score = 115 bits (288), Expect = 9e-26
Identities = 80/300 (26%), Positives = 147/300 (49%), Gaps = 26/300 (8%)
Query: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
C + ++ +G ++D ++ C +LR++ G +++ + + PNL H+
Sbjct: 375 CSRITSLVFTGAPHISDCTFRALSAC--KLRKIRFEGNKRVTDASFKFIDKNYPNLSHIY 432
Query: 245 VSGCSKVTCISLTREASIK------------LSPLHGKQ-------ISIRYLDMTDCFVL 285
++ C +T SL + +K + + KQ + IR L++++C L
Sbjct: 433 MADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRL 492
Query: 286 EDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLV-IYCASIKELSVSDCRFVSDFGLRE 344
D + ++ C L +L LR C LT +G+ Y+V I+ +LS +D +S+ GL
Sbjct: 493 SDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTD---ISNEGLNV 549
Query: 345 IAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKL 404
+++ +L+ LS++ C R+TD GI+ K L +L+ C ++D ++ LA C L
Sbjct: 550 LSR-HKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINL 608
Query: 405 KSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDC 464
SL I CP ++D+ +E L+ C L L + C +T Q L+ + C L+ L +Q C
Sbjct: 609 TSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYC 668
Score = 84.0 bits (206), Expect = 3e-16
Identities = 56/231 (24%), Positives = 106/231 (45%), Gaps = 23/231 (9%)
Query: 188 LETVTVSGCRRLTDRGL--YTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDV 245
L + ++ C R+ D GL + +R L +S C +S+ +V + CPNL +L +
Sbjct: 453 LTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSL 512
Query: 246 SGCSKVTC------ISLTREASIKLSPLHGKQIS------------IRYLDMTDCFVLED 287
C +T +++ SI LS G IS ++ L +++C+ + D
Sbjct: 513 RNCEHLTAQGIGYIVNIFSLVSIDLS---GTDISNEGLNVLSRHKKLKELSVSECYRITD 569
Query: 288 EGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAK 347
+G+ L HL + C +L+D ++ L IYC ++ LS++ C ++D + ++
Sbjct: 570 DGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSA 629
Query: 348 LESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLA 398
L L I+ C +TD + + C +LR L + C I+ + ++
Sbjct: 630 KCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMS 680
Score = 43.5 bits (101), Expect = 4e-04
Identities = 19/77 (24%), Positives = 44/77 (57%)
Query: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
C+ L +++++GC ++TD + ++ C L L++SGC ++++ + D+ C L L
Sbjct: 605 CINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILK 664
Query: 245 VSGCSKVTCISLTREAS 261
+ C+ ++ + R +S
Sbjct: 665 MQYCTNISKKAAQRMSS 681
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 107 bits (268), Expect = 2e-23
Identities = 127/475 (26%), Positives = 207/475 (43%), Gaps = 75/475 (15%)
Query: 64 LPGFQNGRGSSTSSSSITGETVAMVHSP---------PPTRLTHPLIRLA-----SRPQK 109
LPG NG G++ SIT T A + P PP L PL R A P
Sbjct: 23 LPGQPNGLGAA----SITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAG 78
Query: 110 EQASI-------DRLP---DHSMVQ-IFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIR 158
AS +R P D ++ +F + + C A+VC+ W + + P+ W +
Sbjct: 79 GPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLT 138
Query: 159 -----------LTG---ETINVDR----------ALKVLTRRLCQDTPNVCLMLETVTVS 194
L G E +N+ + V +C+ N L + V
Sbjct: 139 PVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAM 198
Query: 195 GCRR--LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVT 252
+R +TD GL + + + RLE+SGC + + ++ SL + L VS
Sbjct: 199 SLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWS--SLSARITSLSVS-----D 251
Query: 253 CISLTREASIKLSPL--HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTH-LYLRRCV 309
CI++ +A +S L + ++S++ +T D L A TH L L C
Sbjct: 252 CINVADDAIAAISQLLPNLAELSLQAYHVT------DTALAYFTARQGHSTHTLRLLSCW 305
Query: 310 RLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIR 369
+T+ G+ +V ++ LS+S C V+D G+ +A+ +LR L ++ C R+TD+ +
Sbjct: 306 EITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALE 365
Query: 370 YVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFN 429
YVA +L L C ITD G+ YL+ + L+SL + C V D GL+ L L +
Sbjct: 366 YVACDLHRLEELVLDRCVRITDTGLSYLS-TMSSLRSLYLRWCCQVQDFGLKHL-LALGS 423
Query: 430 LKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCE-VSVEALRFVKRHCKRCVI 483
L+ LS C +T GL + +L+ L + +C + E ++ +H RC++
Sbjct: 424 LRLLSPAGCPLLTTTGLSGL-VQLQELEELELTNCPGATPELFKYFSQHLPRCLV 477
>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
sapiens]
Length = 303
Score = 94.7 bits (234), Expect = 2e-19
Identities = 71/277 (25%), Positives = 125/277 (45%), Gaps = 15/277 (5%)
Query: 199 LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTR 258
++D G+ +A CP L R C +S+ ++ V S CP L+ + V K+T
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLT------ 54
Query: 259 EASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRY 318
L L K ++ + C+ + DEG+ IA C +L +Y++ +TD+ ++
Sbjct: 55 --DEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKA 112
Query: 319 LVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKL 378
+C ++ + C V+ G+ + KL + L L + H + + + + K C L
Sbjct: 113 FAEHCPELQYVGFMGCS-VTSKGVIHLTKLRN-LSSLDLRHITELDNETVMEIVKRCKNL 170
Query: 379 RYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSC 438
LN I D VE +AK LK L + C ++D L + ++ + + C
Sbjct: 171 SSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWC 229
Query: 439 ESITGQGLQIVAANCFDLQTLNVQDC----EVSVEAL 471
+ IT QG ++A + L+ L + C EV+VE L
Sbjct: 230 KEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQL 266
Score = 82.4 bits (202), Expect = 8e-16
Identities = 55/196 (28%), Positives = 100/196 (51%), Gaps = 2/196 (1%)
Query: 282 CFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFG 341
C L D + +A+HC L +++ +LTDEGL+ L C +K++ C +SD G
Sbjct: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83
Query: 342 LREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNC 401
+ IAK +L+ + + VTD ++ A++C +L+Y+ GC +T GV +L K
Sbjct: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTK-L 141
Query: 402 TKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNV 461
L SLD+ + + + + C NL L+L I + ++++A +L+ L +
Sbjct: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYL 201
Query: 462 QDCEVSVEALRFVKRH 477
C+++ AL + R+
Sbjct: 202 VSCKITDYALIAIGRY 217
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/239 (24%), Positives = 109/239 (45%), Gaps = 11/239 (4%)
Query: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
C +L+ V V +LTD GL + C EL+ + CY IS+E + + C L+ +
Sbjct: 39 CPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIY 98
Query: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304
+ VT + S+K H + ++Y+ C V +H L+ L
Sbjct: 99 MQENKLVT------DQSVKAFAEHCPE--LQYVGFMGCSVTSKGVIH--LTKLRNLSSLD 148
Query: 305 LRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVT 364
LR L +E + +V C ++ L++ ++D + IAK L+ L + C ++T
Sbjct: 149 LRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC-KIT 207
Query: 365 DVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECL 423
D + + +Y + ++ C+ ITD G +A++ L+ L + +C V++ +E L
Sbjct: 208 DYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQL 266
Score = 76.6 bits (187), Expect = 5e-14
Identities = 51/215 (23%), Positives = 101/215 (46%), Gaps = 11/215 (5%)
Query: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
C L+ + C +++D G+ IA+ C +L+R+ + +++++V CP L+++
Sbjct: 65 CRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVG 124
Query: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304
GCS +T + I L+ L ++ LD+ L++E + I C L+ L
Sbjct: 125 FMGCS------VTSKGVIHLTKLR----NLSSLDLRHITELDNETVMEIVKRCKNLSSLN 174
Query: 305 LRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVT 364
L + D + + ++KEL + C+ ++D+ L I + + + + C +T
Sbjct: 175 LCLNWIINDRCVEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEIT 233
Query: 365 DVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAK 399
D G +A+ LRYL C+ + + VE L +
Sbjct: 234 DQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQ 268
Score = 36.2 bits (82), Expect = 0.070
Identities = 18/55 (32%), Positives = 29/55 (52%)
Query: 186 LMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNL 240
+ +ETV V C+ +TD+G IAQ LR L + C ++ V +V P++
Sbjct: 219 MTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHI 273
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 89.0 bits (219), Expect = 9e-18
Identities = 91/345 (26%), Positives = 153/345 (44%), Gaps = 35/345 (10%)
Query: 115 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-RALKVL 173
D+LP + I + L LCR A+ C+ DP + + L +D +L+ L
Sbjct: 281 DKLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFL 340
Query: 174 TRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQ-------CCPELRRLEVSGCYNIS 226
R C +++ + +S +RG ++A C EL RLE+S C +
Sbjct: 341 QSR--------CTLVQWLNLSWTG---NRGFISVAGFSRFLKVCGSELVRLELS-CSHFL 388
Query: 227 NEAVFDVVS-LCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVL 285
NE +V+S +CPNL+ L++S C K+ + A K S++ L + V
Sbjct: 389 NETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIA---------KLCSLKRLVLYRTKV- 438
Query: 286 EDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVI--YCASIKELSVSDCRFVSDFGLR 343
E L +I C++L HL L CV + D + +I C ++ L + C+ +++ G+
Sbjct: 439 EQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIA 498
Query: 344 EIAKLESRLRYLSIAHCGRV-TDVG-IRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNC 401
E+A L L + C + + G +A L+ L + D ++ LA NC
Sbjct: 499 ELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNC 558
Query: 402 TKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGL 446
T+L+ LDI +VS L L +C +L L + C I + +
Sbjct: 559 TRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603
Score = 81.3 bits (199), Expect = 2e-15
Identities = 64/208 (30%), Positives = 99/208 (47%), Gaps = 7/208 (3%)
Query: 277 LDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRF 336
L+++ L + L I+ C L L L C +L + ++ C S+K L + +
Sbjct: 380 LELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVLYRTK- 437
Query: 337 VSDFGLREIAKLESRLRYLSIAHCGRVTDVGI--RYVAKYCSKLRYLNARGCEGITDHGV 394
V L I S L++LS+ C + D + + C KLR L+ C+ IT++G+
Sbjct: 438 VEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGI 497
Query: 395 EYLAKNCTKLKSLDIGKCP-LVSDTG-LECLALNCFNLKRLSLKSCESITGQGLQIVAAN 452
LA C L+ LD+G CP L S TG LA NL++L L + S+ + +A N
Sbjct: 498 AELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACN 557
Query: 453 CFDLQTLNVQDCE-VSVEALRFVKRHCK 479
C LQ L++ VS +LR + CK
Sbjct: 558 CTRLQQLDILGTRMVSPASLRKLLESCK 585
Score = 34.7 bits (78), Expect = 0.20
Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 7/105 (6%)
Query: 389 ITDHGVEYLAKNCTKLKSLDI---GKCPLVSDTGLECLALNCFN-LKRLSLKSCESITGQ 444
+ D +E+L CT ++ L++ G +S G C + L RL L +
Sbjct: 332 LDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNET 391
Query: 445 GLQIVAANCFDLQTLNVQDCE-VSVEALRFVKRHC--KRCVIEHT 486
L++++ C +LQ LN+ C+ + +A + + C KR V+ T
Sbjct: 392 CLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRT 436
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 83.2 bits (204), Expect = 5e-16
Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 7/160 (4%)
Query: 188 LETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSG 247
L +V + GC +L+ R L +A+ CP L+RL ++ C + A+ + CP LE LD++
Sbjct: 116 LRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTA 175
Query: 248 CSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRR 307
C + L EA + L+ G +R L + + D + +A +C +L HL L
Sbjct: 176 CRQ-----LKDEAIVYLAQRRG--AGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTG 228
Query: 308 CVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAK 347
C+R+ +G+R L YC ++ L V C V++ L + K
Sbjct: 229 CLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRK 268
Score = 70.5 bits (171), Expect = 3e-12
Identities = 69/288 (23%), Positives = 116/288 (40%), Gaps = 52/288 (18%)
Query: 119 DHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTG----ETINVDRAL-KVL 173
D + + + +P QL R RV R + +L + L G + V + +
Sbjct: 26 DVLLPHVLNRVPLRQLLRLQRVSRAFRSLV-------QLHLAGLRRFDAAQVGPQIPRAA 78
Query: 174 TRRLCQDTPNVCLMLETVTVSGCRR-LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFD 232
RL +D L+ + ++ C L+D L + P+LR + + GC +S A+
Sbjct: 79 LARLLRDAEG----LQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGA 134
Query: 233 VVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHT 292
+ CP L+ L ++ C V ++L
Sbjct: 135 LAEGCPRLQRLSLAHCDWVDGLAL----------------------------------RG 160
Query: 293 IAAHCTQLTHLYLRRCVRLTDEGLRYLVIYC-ASIKELSVSDCRFVSDFGLREIAKLESR 351
+A C L L L C +L DE + YL A ++ LS++ V D ++E+A+
Sbjct: 161 LADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPE 220
Query: 352 LRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAK 399
L +L + C RV G+R +A+YC LR L R C + + + L K
Sbjct: 221 LHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRK 268
Score = 68.9 bits (167), Expect = 1e-11
Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 285 LEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLRE 344
L DE L + A QL + L C +L+ L L C ++ LS++ C +V LR
Sbjct: 101 LSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG 160
Query: 345 IAKLESRLRYLSIAHCGRVTDVGIRYVA-KYCSKLRYLNARGCEGITDHGVEYLAKNCTK 403
+A L L + C ++ D I Y+A + + LR L+ + D V+ LA+NC +
Sbjct: 161 LADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPE 220
Query: 404 LKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGL 446
L LD+ C V G+ LA C L+ L ++ C + L
Sbjct: 221 LHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSL 263
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/156 (25%), Positives = 79/156 (50%), Gaps = 3/156 (1%)
Query: 326 IKELSVSDCR-FVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNAR 384
++EL+++ C ++SD L + +LR +++ CG+++ + +A+ C +L+ L+
Sbjct: 89 LQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLA 148
Query: 385 GCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLA-LNCFNLKRLSLKSCESITG 443
C+ + + LA C L+ LD+ C + D + LA L+ LSL ++
Sbjct: 149 HCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGD 208
Query: 444 QGLQIVAANCFDLQTLNVQDC-EVSVEALRFVKRHC 478
+Q +A NC +L L++ C V + +R + +C
Sbjct: 209 AAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYC 244
>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
sapiens]
Length = 539
Score = 80.9 bits (198), Expect = 2e-15
Identities = 106/418 (25%), Positives = 164/418 (39%), Gaps = 74/418 (17%)
Query: 115 DRLPDHSMVQIFSFL-----PTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-- 167
DR+P +VQIF L P L R ARVCRRW A P LW T+ L+ +
Sbjct: 113 DRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAK 172
Query: 168 ---RALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYN 224
+A K L L PN L+ +T+ + L + +CCP L L++SGC+
Sbjct: 173 GGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHG 232
Query: 225 ISNEAVFDVVSLCPNLEHLDV--SGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDC 282
++ +A+ + C L LD+ S +S EA ++ +++ + Y T
Sbjct: 233 VTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRM-----RKLWLTYSSQTTA 287
Query: 283 F-------------VLE-DEGLH-----------TIAAHCTQLTHLYLRRCVRLTDEGLR 317
VLE G++ + C QL L L + L R
Sbjct: 288 ILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLRLLNLMWLPKPPGR 347
Query: 318 YLV--IYCASIKELSV--SDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAK 373
+ S++EL + S C FVS+ L + LR L + C R+T G++ +
Sbjct: 348 GVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLP- 406
Query: 374 YCSKLRYLNARGCEGITD------HGVEYLA-KNCTKLKSLDI------------GKCPL 414
C +L L+ G G +D G +L K C L+ LD+
Sbjct: 407 -CRELEQLHL-GLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAF 464
Query: 415 VSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALR 472
+S G AL NL+ +T + V ++C L LN++ C L+
Sbjct: 465 LSTPGGSHPALCSLNLRG------TRVTPSTVSSVISSCPGLLYLNLESCRCLPRGLK 516
>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
sapiens]
Length = 533
Score = 76.3 bits (186), Expect = 6e-14
Identities = 105/418 (25%), Positives = 163/418 (38%), Gaps = 80/418 (19%)
Query: 115 DRLPDHSMVQIFSFL-----PTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-- 167
DR+P +VQIF L P L R ARVCRRW A P LW T+ L+ +
Sbjct: 113 DRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAK 172
Query: 168 ---RALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYN 224
+A K L L PN L+ +T+ + + +CCP L L++SGC+
Sbjct: 173 GGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKS------QLVGECCPRLTFLKLSGCHG 226
Query: 225 ISNEAVFDVVSLCPNLEHLDV--SGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDC 282
++ +A+ + C L LD+ S +S EA ++ +++ + Y T
Sbjct: 227 VTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRM-----RKLWLTYSSQTTA 281
Query: 283 F-------------VLE-DEGLH-----------TIAAHCTQLTHLYLRRCVRLTDEGLR 317
VLE G++ + C QL L L + L R
Sbjct: 282 ILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLRLLNLMWLPKPPGR 341
Query: 318 YLV--IYCASIKELSV--SDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAK 373
+ S++EL + S C FVS+ L + LR L + C R+T G++ +
Sbjct: 342 GVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLP- 400
Query: 374 YCSKLRYLNARGCEGITD------HGVEYLA-KNCTKLKSLDI------------GKCPL 414
C +L L+ G G +D G +L K C L+ LD+
Sbjct: 401 -CRELEQLHL-GLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAF 458
Query: 415 VSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALR 472
+S G AL NL+ +T + V ++C L LN++ C L+
Sbjct: 459 LSTPGGSHPALCSLNLRG------TRVTPSTVSSVISSCPGLLYLNLESCRCLPRGLK 510
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 75.5 bits (184), Expect = 1e-13
Identities = 75/286 (26%), Positives = 127/286 (44%), Gaps = 48/286 (16%)
Query: 113 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKV 172
S D LPD ++ IFS L +L + + VC+RWY LA D LW+T+ LTG+ ++ D ++
Sbjct: 96 SWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRL 155
Query: 173 LTR--------RLCQDTP-----------------------------NVCLMLETVTVSG 195
L++ R D P + C L+ +++ G
Sbjct: 156 LSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEG 215
Query: 196 CRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCIS 255
RL+D + T+A+ L RL +SGC S A+ ++S C L+ L++S C T
Sbjct: 216 L-RLSDPIVNTLAK-NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFT--- 270
Query: 256 LTREASIKLSPLHGKQISIRYLDMTDCFV-LEDEGLHTIAAHCTQLTHLYLRRCVRLTDE 314
E ++++ H + +I L+++ L+ L T+ C L HL L V L ++
Sbjct: 271 ---EKHVQVAVAHVSE-TITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKND 326
Query: 315 GLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHC 360
+ ++ LS+S C + L + + R+R S C
Sbjct: 327 CFQEF-FQLNYLQHLSLSRCYDIIPETLLLVTRAGVRIRLDSDIGC 371
Score = 57.0 bits (136), Expect = 4e-08
Identities = 69/251 (27%), Positives = 119/251 (47%), Gaps = 18/251 (7%)
Query: 210 CCPELRRLEVSGC----YNI-SNEAVFDVVSLCPNLEHLDVSG-CSKVTCISLTREASIK 263
C PEL L+VSG Y + S+E+++ + L H DV+G I+ S
Sbjct: 113 CLPEL--LKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFM 170
Query: 264 LSPL--HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVI 321
PL H ++++D+++ V+E LH I + C++L +L L +RL+D + L
Sbjct: 171 DQPLAEHFSPFRVQHMDLSNS-VIEVSTLHGILSQCSKLQNLSLEG-LRLSDPIVNTLAK 228
Query: 322 YCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSK-LRY 380
+++ L++S C S+F L+ + SRL L+++ C T+ ++ + S+ +
Sbjct: 229 N-SNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQ 287
Query: 381 LNARGC-EGITDHGVEYLAKNCTKLKSLDIG-KCPLVSDTGLECLALNCFNLKRLSLKSC 438
LN G + + + L + C L LD+ L +D E LN L+ LSL C
Sbjct: 288 LNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLN--YLQHLSLSRC 345
Query: 439 ESITGQGLQIV 449
I + L +V
Sbjct: 346 YDIIPETLLLV 356
Score = 35.4 bits (80), Expect = 0.12
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 390 TDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIV 449
T HG+ C+KL++L + L SD + LA N NL RL+L C + LQ +
Sbjct: 197 TLHGI---LSQCSKLQNLSLEGLRL-SDPIVNTLAKNS-NLVRLNLSGCSGFSEFALQTL 251
Query: 450 AANCFDLQTLNVQDC 464
++C L LN+ C
Sbjct: 252 LSSCSRLDELNLSWC 266
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 75.1 bits (183), Expect = 1e-13
Identities = 72/274 (26%), Positives = 124/274 (45%), Gaps = 48/274 (17%)
Query: 113 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKV 172
S D LPD ++ IFS L +L + + VC+RWY LA D LW+T+ LTG+ ++ D ++
Sbjct: 96 SWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRL 155
Query: 173 LTR--------RLCQDTP-----------------------------NVCLMLETVTVSG 195
L++ R D P + C L+ +++ G
Sbjct: 156 LSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEG 215
Query: 196 CRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCIS 255
RL+D + T+A+ L RL +SGC S A+ ++S C L+ L++S C T
Sbjct: 216 L-RLSDPIVNTLAK-NSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFT--- 270
Query: 256 LTREASIKLSPLHGKQISIRYLDMTDCFV-LEDEGLHTIAAHCTQLTHLYLRRCVRLTDE 314
E ++++ H + +I L+++ L+ L T+ C L HL L V L ++
Sbjct: 271 ---EKHVQVAVAHVSE-TITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKND 326
Query: 315 GLRYLVIYCASIKELSVSDCRFVSDFGLREIAKL 348
+ ++ LS+S C + L E+ ++
Sbjct: 327 CFQEF-FQLNYLQHLSLSRCYDIIPETLLELGEI 359
Score = 55.5 bits (132), Expect = 1e-07
Identities = 68/248 (27%), Positives = 117/248 (47%), Gaps = 18/248 (7%)
Query: 210 CCPELRRLEVSGC----YNI-SNEAVFDVVSLCPNLEHLDVSG-CSKVTCISLTREASIK 263
C PEL L+VSG Y + S+E+++ + L H DV+G I+ S
Sbjct: 113 CLPEL--LKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFM 170
Query: 264 LSPL--HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVI 321
PL H ++++D+++ V+E LH I + C++L +L L +RL+D + L
Sbjct: 171 DQPLAEHFSPFRVQHMDLSNS-VIEVSTLHGILSQCSKLQNLSLEG-LRLSDPIVNTLAK 228
Query: 322 YCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSK-LRY 380
+++ L++S C S+F L+ + SRL L+++ C T+ ++ + S+ +
Sbjct: 229 N-SNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQ 287
Query: 381 LNARGC-EGITDHGVEYLAKNCTKLKSLDIG-KCPLVSDTGLECLALNCFNLKRLSLKSC 438
LN G + + + L + C L LD+ L +D E LN L+ LSL C
Sbjct: 288 LNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLN--YLQHLSLSRC 345
Query: 439 ESITGQGL 446
I + L
Sbjct: 346 YDIIPETL 353
Score = 35.4 bits (80), Expect = 0.12
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 390 TDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIV 449
T HG+ C+KL++L + L SD + LA N NL RL+L C + LQ +
Sbjct: 197 TLHGI---LSQCSKLQNLSLEGLRL-SDPIVNTLAKNS-NLVRLNLSGCSGFSEFALQTL 251
Query: 450 AANCFDLQTLNVQDC 464
++C L LN+ C
Sbjct: 252 LSSCSRLDELNLSWC 266
>gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]
Length = 326
Score = 73.2 bits (178), Expect = 5e-13
Identities = 69/258 (26%), Positives = 114/258 (44%), Gaps = 31/258 (12%)
Query: 112 ASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALK 171
A++ LPD +++IFS+LP R +RVC RW L D LWR + LT T+
Sbjct: 2 ATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWH 61
Query: 172 VLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVF 231
+L R + ++ + + S +L+ L + Q CP L+RL C ++++ ++
Sbjct: 62 LLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRL----CLHVADLSMV 117
Query: 232 DVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLE----- 286
+ SL L L++ C I ++ LH KQ L + +C VL+
Sbjct: 118 PITSLPSTLRTLELHSC------------EISMAWLH-KQQDPTVLPLLECIVLDRVPAF 164
Query: 287 -DEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDF----- 340
DE L + L L L R+T+ GL + + ++ L V C +D
Sbjct: 165 RDEHLQGL-TRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAI 223
Query: 341 --GLREIAKLESRLRYLS 356
LR++ K+ +R LS
Sbjct: 224 SRHLRDVRKIRLTVRGLS 241
>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
Length = 258
Score = 69.3 bits (168), Expect = 7e-12
Identities = 59/228 (25%), Positives = 105/228 (46%), Gaps = 37/228 (16%)
Query: 198 RLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLT 257
++TD + I PE++ L++ C +IS+ A+ L +S C K+
Sbjct: 49 QITDSNISEILH--PEVQTLDLRSC-DISDAAL------------LHLSNCRKLK----- 88
Query: 258 REASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLR 317
+ L+ G ++S+ EG+ +A+ C+ L L+RC LTDEG+
Sbjct: 89 ---KLNLNASKGNRVSVT-----------SEGIKAVASSCSYLHEASLKRCCNLTDEGVV 134
Query: 318 YLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVG-IRYVAKYCS 376
L + C +K + + C ++D L + K L+ + + +V+D G I V+ C+
Sbjct: 135 ALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCA 193
Query: 377 -KLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECL 423
KL ++ C +TD VE + C +++ L CPL++D E L
Sbjct: 194 KKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVL 241
Score = 62.4 bits (150), Expect = 9e-10
Identities = 40/135 (29%), Positives = 70/135 (51%), Gaps = 8/135 (5%)
Query: 337 VSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEG----ITDH 392
++D + EI L ++ L + C ++D + +++ C KL+ LN +G +T
Sbjct: 50 ITDSNISEI--LHPEVQTLDLRSCD-ISDAALLHLSN-CRKLKKLNLNASKGNRVSVTSE 105
Query: 393 GVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAAN 452
G++ +A +C+ L + +C ++D G+ LALNC LK + L C SIT L + N
Sbjct: 106 GIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
Query: 453 CFDLQTLNVQDCEVS 467
C LQ ++ +VS
Sbjct: 166 CPFLQCVDFSATQVS 180
Score = 58.5 bits (140), Expect = 1e-08
Identities = 39/147 (26%), Positives = 67/147 (45%), Gaps = 6/147 (4%)
Query: 310 RLTDEGLRYLV---IYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDV 366
++TD + ++ + ++ +SD + R++ KL S + VT
Sbjct: 49 QITDSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNA---SKGNRVSVTSE 105
Query: 367 GIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALN 426
GI+ VA CS L + + C +TD GV LA NC LK +D+G C ++D L L N
Sbjct: 106 GIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
Query: 427 CFNLKRLSLKSCESITGQGLQIVAANC 453
C L+ + + + + +V+ C
Sbjct: 166 CPFLQCVDFSATQVSDSGVIALVSGPC 192
Score = 56.6 bits (135), Expect = 5e-08
Identities = 36/151 (23%), Positives = 69/151 (45%), Gaps = 9/151 (5%)
Query: 199 LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTR 258
+T G+ +A C L + C N+++E V + C L+ +D+ GC +T +SL
Sbjct: 102 VTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSL-- 159
Query: 259 EASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQ-LTHLYLRRCVRLTDEGLR 317
A K P ++ +D + V + + ++ C + L +++ CV LTD +
Sbjct: 160 HALGKNCPF------LQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVE 213
Query: 318 YLVIYCASIKELSVSDCRFVSDFGLREIAKL 348
++ YC I+ L C ++D + +L
Sbjct: 214 AVLTYCPQIRILLFHGCPLITDHSREVLEQL 244
Score = 50.1 bits (118), Expect = 5e-06
Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 7/135 (5%)
Query: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
C L ++ C LTD G+ +A C L+ +++ GC +I++ ++ + CP L+ +D
Sbjct: 114 CSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVD 173
Query: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304
S T +S + ++ P K + + M C L D + + +C Q+ L
Sbjct: 174 FS----ATQVSDSGVIALVSGPCAKK---LEEIHMGHCVNLTDGAVEAVLTYCPQIRILL 226
Query: 305 LRRCVRLTDEGLRYL 319
C +TD L
Sbjct: 227 FHGCPLITDHSREVL 241
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/359 (23%), Positives = 141/359 (39%), Gaps = 51/359 (14%)
Query: 16 SSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSST 75
+SS SSD S +D + T ++ A E + + +N G
Sbjct: 323 TSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK----------ENRGGRRA 372
Query: 76 SSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLP-----DHSM-----VQI 125
G ++ P P L R RP D LP DH + +++
Sbjct: 373 VRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRV 432
Query: 126 FSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI-----------RLTGETINVDRALKV-- 172
F L +LC C RVCR W +D RLW + L+G RAL +
Sbjct: 433 FQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSW 492
Query: 173 --LTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAV 230
++++ N L+ + +SGC L+ L + P LR L++ ++ + +
Sbjct: 493 TGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAP--LPALRLLDLRWIEDVKDSQL 550
Query: 231 FDVVSLCPNLEHLDVSGCSKVTCISLTR-------EASIKLSPLHGKQISIRYLDMTDCF 283
+++ P+ + ++ ++ R +AS++L H Q+S LD++ C
Sbjct: 551 RELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSA--LDLSHCA 608
Query: 284 VLEDEGLHTIAAHCT----QLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVS 338
+ D +H + A + L HL L C RLTD L L C ++ L + CR +S
Sbjct: 609 HVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLP-LFRRCPRLRRLDLRSCRQLS 666
Score = 35.4 bits (80), Expect = 0.12
Identities = 17/39 (43%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Query: 191 VTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEA 229
+ ++GC RLTD L + + CP LRRL++ C +S EA
Sbjct: 632 LNLAGCHRLTDHCL-PLFRRCPRLRRLDLRSCRQLSPEA 669
Score = 31.2 bits (69), Expect = 2.2
Identities = 25/109 (22%), Positives = 50/109 (45%), Gaps = 14/109 (12%)
Query: 157 IRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRR 216
+RL G + D +L++L R Q L + +S C + D ++ + LR
Sbjct: 577 LRLAGLELT-DASLRLLLRHAPQ--------LSALDLSHCAHVGDPSVHLLTAPTSPLRE 627
Query: 217 ----LEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREAS 261
L ++GC+ +++ + + CP L LD+ C +++ + R A+
Sbjct: 628 TLVHLNLAGCHRLTDHCL-PLFRRCPRLRRLDLRSCRQLSPEACARLAA 675
Score = 31.2 bits (69), Expect = 2.2
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 389 ITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLK----RLSLKSCESITGQ 444
+TD + L ++ +L +LD+ C V D + L L+ L+L C +T
Sbjct: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
Query: 445 GLQIVAANCFDLQTLNVQDC-EVSVEA 470
L + C L+ L+++ C ++S EA
Sbjct: 644 CLPLF-RRCPRLRRLDLRSCRQLSPEA 669
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
sapiens]
Length = 1265
Score = 66.2 bits (160), Expect = 6e-11
Identities = 85/328 (25%), Positives = 126/328 (38%), Gaps = 52/328 (15%)
Query: 88 VHSPPPTRLTHP----LIRLASRPQKEQASIDRLP-----DHSM-----VQIFSFLPTNQ 133
V S PP ++ P + R RP D LP H M + +FS+L
Sbjct: 953 VISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQD 1012
Query: 134 LCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTV 193
LC C RVCR W D RLW I L L + RR V L L +
Sbjct: 1013 LCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRR-----QPVSLDLSWTNI 1067
Query: 194 SGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTC 253
S + L + P LR L +SGC I+ A+ S CP L LDV +
Sbjct: 1068 S------KKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKD 1119
Query: 254 ISLTREASIKLSPLHGK-----------QISIRYLDMTDCFVLEDEGLHTIAAHCTQLTH 302
+ S G+ ++ + LD+TD L I H L+
Sbjct: 1120 AQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDA------SLRLIIRHMPLLSK 1173
Query: 303 LYLRRCVRLTDEGLRYLVIYCA----SIKELSVSDCRFVSDFGLREIAKLESRLRYLSIA 358
L+L C +TD+ + L S+ E+++SDC V+D L K + ++ +
Sbjct: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCL-SFFKRCGNICHIDLR 1232
Query: 359 HCGRVTDVGIRYVAKYCSKLRYLNARGC 386
+C +VT G ++ +++ R C
Sbjct: 1233 YCKQVTKEGCE---QFIAEMSSFQGRSC 1257
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/278 (24%), Positives = 114/278 (41%), Gaps = 41/278 (14%)
Query: 123 VQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTP 182
+ +F +L +LC C RVC+ WY D RLW I L+ V +AL + +R
Sbjct: 899 MSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKR-----Q 953
Query: 183 NVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEH 242
V L L +S + L + P L+ L ++GC + A+ S CP L
Sbjct: 954 PVSLDLSWTNIS------KKQLTWLVNRLPGLKDLLLAGCSWSAVSAL--STSSCPLLRT 1005
Query: 243 LDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFV----LEDEGLHTIAAHCT 298
LD+ + + R+ + G+ + +MTD + + D L I H
Sbjct: 1006 LDLRWAVGIKDPQI-RDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMP 1064
Query: 299 QLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIA 358
L+ L L C LTD+ L +S + + L E L++A
Sbjct: 1065 LLSRLDLSHCSHLTDQSSNLLTAVGSSTR------------YSLTE----------LNMA 1102
Query: 359 HCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEY 396
C ++TD + Y+ + + + ++ RGC+ IT E+
Sbjct: 1103 GCNKLTDQTLIYLRR-IANVTLIDLRGCKQITRKACEH 1139
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 65.1 bits (157), Expect = 1e-10
Identities = 83/309 (26%), Positives = 119/309 (38%), Gaps = 49/309 (15%)
Query: 88 VHSPPPTRLTHP----LIRLASRPQKEQASIDRLP-----DHSM-----VQIFSFLPTNQ 133
V S PP ++ P + R RP D LP H M + +FS+L
Sbjct: 1022 VISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQD 1081
Query: 134 LCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTV 193
LC C RVCR W D RLW I L L + RR V L L +
Sbjct: 1082 LCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRR-----QPVSLDLSWTNI 1136
Query: 194 SGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTC 253
S + L + P LR L +SGC I+ A+ S CP L LDV +
Sbjct: 1137 S------KKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKD 1188
Query: 254 ISLTREASIKLSPLHGK-----------QISIRYLDMTDCFVLEDEGLHTIAAHCTQLTH 302
+ S G+ ++ + LD+TD L I H L+
Sbjct: 1189 AQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDA------SLRLIIRHMPLLSK 1242
Query: 303 LYLRRCVRLTDEGLRYLVIYCA----SIKELSVSDCRFVSDFGLREIAKLESRLRYLSIA 358
L+L C +TD+ + L S+ E+++SDC V+D L K + ++ +
Sbjct: 1243 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCL-SFFKRCGNICHIDLR 1301
Query: 359 HCGRVTDVG 367
+C +VT G
Sbjct: 1302 YCKQVTKEG 1310
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/114 (29%), Positives = 62/114 (54%), Gaps = 1/114 (0%)
Query: 300 LTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH 359
L L L C +LTD L V+ +++LS+S ++D GL +A+ L +L+++H
Sbjct: 77 LQELDLTACSKLTDASLAK-VLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 360 CGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCP 413
C R++D G A +L++LN C + + ++ + + C +L+ LD+ CP
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCP 189
Score = 60.1 bits (144), Expect = 5e-09
Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 1/117 (0%)
Query: 273 SIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVS 332
+++ LD+T C L D L + QL L L LTD GL + C S++ L++S
Sbjct: 76 ALQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 333 DCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGI 389
C +SD G + A RL++L+++ C ++ + + + + C +LR L+ C GI
Sbjct: 135 HCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGI 191
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/122 (28%), Positives = 63/122 (51%), Gaps = 2/122 (1%)
Query: 352 LRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGK 411
L+ L + C ++TD + V ++ +LR L+ +TD+G+ +A+ C L+ L +
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 412 CPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCE-VSVEA 470
C +SD G A + L+ L+L SC + Q L + C L+ L+V C +++ A
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 471 LR 472
+R
Sbjct: 196 VR 197
Score = 56.6 bits (135), Expect = 5e-08
Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 9/130 (6%)
Query: 240 LEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQ 299
L+ LD++ CSK+T SL + + +R L ++ L D GL +A C
Sbjct: 77 LQELDLTACSKLTDASLAKVLQF---------LQLRQLSLSLLPELTDNGLVAVARGCPS 127
Query: 300 LTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH 359
L HL L C RL+D+G ++ L++S C + + L I + +LR L +A
Sbjct: 128 LEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVAT 187
Query: 360 CGRVTDVGIR 369
C + +R
Sbjct: 188 CPGINMAAVR 197
Score = 53.1 bits (126), Expect = 6e-07
Identities = 30/117 (25%), Positives = 61/117 (52%), Gaps = 1/117 (0%)
Query: 325 SIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNAR 384
+++EL ++ C ++D L ++ + +LR LS++ +TD G+ VA+ C L +L
Sbjct: 76 ALQELDLTACSKLTDASLAKVLQF-LQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 385 GCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESI 441
C ++D G A + +L+ L++ C + + L+ + C L+ L + +C I
Sbjct: 135 HCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGI 191
Score = 52.0 bits (123), Expect = 1e-06
Identities = 39/150 (26%), Positives = 73/150 (48%), Gaps = 12/150 (8%)
Query: 188 LETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSG 247
L+ + ++ C +LTD L + Q +LR+L +S +++ + V CP+LEHL +S
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 248 CSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRR 307
CS+++ + AS +++L+++ C L ++ L I C QL L +
Sbjct: 136 CSRLSDKGWAQAAS--------SWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVAT 187
Query: 308 CVRLTDEGLRYLVIYCASIKELSVSDCRFV 337
C + +R + A + ++S RFV
Sbjct: 188 CPGINMAAVRR---FQAQLPQVSCVQSRFV 214
Score = 50.1 bits (118), Expect = 5e-06
Identities = 24/66 (36%), Positives = 38/66 (57%)
Query: 186 LMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDV 245
L L +++S LTD GL +A+ CP L L +S C +S++ S P L+HL++
Sbjct: 100 LQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNL 159
Query: 246 SGCSKV 251
S CS++
Sbjct: 160 SSCSQL 165
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 100 LIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRL 159
L+ L + + + + +L D S+ ++ FL QL +L+ P L
Sbjct: 71 LLTLRALQELDLTACSKLTDASLAKVLQFLQLRQL-----------SLSLLPEL------ 113
Query: 160 TGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEV 219
D L + R C LE + +S C RL+D+G A P L+ L +
Sbjct: 114 ------TDNGLVAVARG--------CPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNL 159
Query: 220 SGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTR 258
S C + + + + C L LDV+ C + ++ R
Sbjct: 160 SSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAAVRR 198
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/114 (29%), Positives = 62/114 (54%), Gaps = 1/114 (0%)
Query: 300 LTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH 359
L L L C +LTD L V+ +++LS+S ++D GL +A+ L +L+++H
Sbjct: 77 LQELDLTACSKLTDASLAK-VLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 360 CGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCP 413
C R++D G A +L++LN C + + ++ + + C +L+ LD+ CP
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCP 189
Score = 60.1 bits (144), Expect = 5e-09
Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 1/117 (0%)
Query: 273 SIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVS 332
+++ LD+T C L D L + QL L L LTD GL + C S++ L++S
Sbjct: 76 ALQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 333 DCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGI 389
C +SD G + A RL++L+++ C ++ + + + + C +LR L+ C GI
Sbjct: 135 HCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGI 191
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/122 (28%), Positives = 63/122 (51%), Gaps = 2/122 (1%)
Query: 352 LRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGK 411
L+ L + C ++TD + V ++ +LR L+ +TD+G+ +A+ C L+ L +
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 412 CPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCE-VSVEA 470
C +SD G A + L+ L+L SC + Q L + C L+ L+V C +++ A
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 471 LR 472
+R
Sbjct: 196 VR 197
Score = 56.6 bits (135), Expect = 5e-08
Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 9/130 (6%)
Query: 240 LEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQ 299
L+ LD++ CSK+T SL + + +R L ++ L D GL +A C
Sbjct: 77 LQELDLTACSKLTDASLAKVLQF---------LQLRQLSLSLLPELTDNGLVAVARGCPS 127
Query: 300 LTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH 359
L HL L C RL+D+G ++ L++S C + + L I + +LR L +A
Sbjct: 128 LEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVAT 187
Query: 360 CGRVTDVGIR 369
C + +R
Sbjct: 188 CPGINMAAVR 197
Score = 53.1 bits (126), Expect = 6e-07
Identities = 30/117 (25%), Positives = 61/117 (52%), Gaps = 1/117 (0%)
Query: 325 SIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNAR 384
+++EL ++ C ++D L ++ + +LR LS++ +TD G+ VA+ C L +L
Sbjct: 76 ALQELDLTACSKLTDASLAKVLQF-LQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 385 GCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESI 441
C ++D G A + +L+ L++ C + + L+ + C L+ L + +C I
Sbjct: 135 HCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGI 191
Score = 52.0 bits (123), Expect = 1e-06
Identities = 39/150 (26%), Positives = 73/150 (48%), Gaps = 12/150 (8%)
Query: 188 LETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSG 247
L+ + ++ C +LTD L + Q +LR+L +S +++ + V CP+LEHL +S
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFL-QLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 248 CSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRR 307
CS+++ + AS +++L+++ C L ++ L I C QL L +
Sbjct: 136 CSRLSDKGWAQAAS--------SWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVAT 187
Query: 308 CVRLTDEGLRYLVIYCASIKELSVSDCRFV 337
C + +R + A + ++S RFV
Sbjct: 188 CPGINMAAVRR---FQAQLPQVSCVQSRFV 214
Score = 50.1 bits (118), Expect = 5e-06
Identities = 24/66 (36%), Positives = 38/66 (57%)
Query: 186 LMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDV 245
L L +++S LTD GL +A+ CP L L +S C +S++ S P L+HL++
Sbjct: 100 LQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNL 159
Query: 246 SGCSKV 251
S CS++
Sbjct: 160 SSCSQL 165
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 100 LIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRL 159
L+ L + + + + +L D S+ ++ FL QL +L+ P L
Sbjct: 71 LLTLRALQELDLTACSKLTDASLAKVLQFLQLRQL-----------SLSLLPEL------ 113
Query: 160 TGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEV 219
D L + R C LE + +S C RL+D+G A P L+ L +
Sbjct: 114 ------TDNGLVAVARG--------CPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNL 159
Query: 220 SGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTR 258
S C + + + + C L LDV+ C + ++ R
Sbjct: 160 SSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAAVRR 198
>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
sapiens]
Length = 565
Score = 50.4 bits (119), Expect = 4e-06
Identities = 92/453 (20%), Positives = 157/453 (34%), Gaps = 109/453 (24%)
Query: 109 KEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRW-------------YNLAWDPRLW- 154
+ I LP M+ IFS+L +LCRC++V +W Y + W W
Sbjct: 74 EHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWY 133
Query: 155 -----------------------RTIRLTGETINVDRA-----------LKVLTRRLCQD 180
R E ++D + + + +RL
Sbjct: 134 SGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHG 193
Query: 181 T-----PNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAV--FDV 233
P V ++T+ ++ ++ + + I + CP L L+++ +IS+ A +
Sbjct: 194 LIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT-DISDSAFDSWSW 252
Query: 234 VSLCPNLEHLDVSGCSKVTCISL-------------------TREASIKLSPLHGKQISI 274
+ C +L HLD+SGC K+T ++L T + I + K I++
Sbjct: 253 LGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITM 312
Query: 275 RYLDMTDCF----------VLEDEGLHTIAAHCTQLTHLY-----------LRRCVRLTD 313
+ C +++E T T Y + V
Sbjct: 313 QSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRH 372
Query: 314 EGLRYL-VIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGR---VTDVGIR 369
+ L V+ AS S S C GLR + + A+CG T +R
Sbjct: 373 RNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALR 432
Query: 370 YVAK------YCSKLRYLNARGCEGITDHGVEYLAKNCTK-LKSLDIGKCPLVSDTGLEC 422
++ C K + + G E + + L L + C ++D GL
Sbjct: 433 TMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRV 492
Query: 423 LAL--NCFNLKRLSLKSCESITGQGLQIVAANC 453
L L L+ L+L C +ITG GLQ + + C
Sbjct: 493 LTLGGGLPYLEHLNLSGCLTITGAGLQDLVSAC 525
Score = 47.4 bits (111), Expect = 3e-05
Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 19/91 (20%)
Query: 179 QDTPNVCLMLETVTVSGCRRLTDRGL--YTIAQCCPELRRLEVSGCYNISNEAVFDVVSL 236
Q+T V L L ++SGC ++TD GL T+ P L L +SGC I+ + D+VS
Sbjct: 468 QETGRVLLFL---SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSA 524
Query: 237 CPNLE-------------HLD-VSGCSKVTC 253
CP+L H D SGC + C
Sbjct: 525 CPSLNDEYFYYCDNINGPHADTASGCQNLQC 555
Score = 37.4 bits (85), Expect = 0.031
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 378 LRYLNARGCEGITDHGVEY--LAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSL 435
L +L+ GC ITDHG+ L L+ L++ C ++ GL+ L C +L
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 436 KSCESITGQGLQIVAANCFDLQ 457
C++I G A+ C +LQ
Sbjct: 534 YYCDNINGPHAD-TASGCQNLQ 554
Score = 35.8 bits (81), Expect = 0.091
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 352 LRYLSIAHCGRVTDVGIRY--VAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDI 409
L +LS++ C ++TD G+R + L +LN GC IT G++ L C L
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 410 GKCPLV----SDTGLECLALNC 427
C + +DT C L C
Sbjct: 534 YYCDNINGPHADTASGCQNLQC 555
Score = 35.8 bits (81), Expect = 0.091
Identities = 18/55 (32%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 276 YLDMTDCFVLEDEGLH--TIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKE 328
+L ++ C+ + D GL T+ L HL L C+ +T GL+ LV C S+ +
Sbjct: 476 FLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLND 530
>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
sapiens]
Length = 691
Score = 50.4 bits (119), Expect = 4e-06
Identities = 92/453 (20%), Positives = 157/453 (34%), Gaps = 109/453 (24%)
Query: 109 KEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRW-------------YNLAWDPRLW- 154
+ I LP M+ IFS+L +LCRC++V +W Y + W W
Sbjct: 200 EHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWY 259
Query: 155 -----------------------RTIRLTGETINVDRA-----------LKVLTRRLCQD 180
R E ++D + + + +RL
Sbjct: 260 SGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHG 319
Query: 181 T-----PNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAV--FDV 233
P V ++T+ ++ ++ + + I + CP L L+++ +IS+ A +
Sbjct: 320 LIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT-DISDSAFDSWSW 378
Query: 234 VSLCPNLEHLDVSGCSKVTCISL-------------------TREASIKLSPLHGKQISI 274
+ C +L HLD+SGC K+T ++L T + I + K I++
Sbjct: 379 LGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITM 438
Query: 275 RYLDMTDCF----------VLEDEGLHTIAAHCTQLTHLY-----------LRRCVRLTD 313
+ C +++E T T Y + V
Sbjct: 439 QSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRH 498
Query: 314 EGLRYL-VIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGR---VTDVGIR 369
+ L V+ AS S S C GLR + + A+CG T +R
Sbjct: 499 RNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALR 558
Query: 370 YVAK------YCSKLRYLNARGCEGITDHGVEYLAKNCTK-LKSLDIGKCPLVSDTGLEC 422
++ C K + + G E + + L L + C ++D GL
Sbjct: 559 TMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRV 618
Query: 423 LAL--NCFNLKRLSLKSCESITGQGLQIVAANC 453
L L L+ L+L C +ITG GLQ + + C
Sbjct: 619 LTLGGGLPYLEHLNLSGCLTITGAGLQDLVSAC 651
Score = 47.4 bits (111), Expect = 3e-05
Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 19/91 (20%)
Query: 179 QDTPNVCLMLETVTVSGCRRLTDRGL--YTIAQCCPELRRLEVSGCYNISNEAVFDVVSL 236
Q+T V L L ++SGC ++TD GL T+ P L L +SGC I+ + D+VS
Sbjct: 594 QETGRVLLFL---SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSA 650
Query: 237 CPNLE-------------HLD-VSGCSKVTC 253
CP+L H D SGC + C
Sbjct: 651 CPSLNDEYFYYCDNINGPHADTASGCQNLQC 681
Score = 37.4 bits (85), Expect = 0.031
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 378 LRYLNARGCEGITDHGVEY--LAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSL 435
L +L+ GC ITDHG+ L L+ L++ C ++ GL+ L C +L
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 436 KSCESITGQGLQIVAANCFDLQ 457
C++I G A+ C +LQ
Sbjct: 660 YYCDNINGPHAD-TASGCQNLQ 680
Score = 35.8 bits (81), Expect = 0.091
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 352 LRYLSIAHCGRVTDVGIRY--VAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDI 409
L +LS++ C ++TD G+R + L +LN GC IT G++ L C L
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 410 GKCPLV----SDTGLECLALNC 427
C + +DT C L C
Sbjct: 660 YYCDNINGPHADTASGCQNLQC 681
Score = 35.8 bits (81), Expect = 0.091
Identities = 18/55 (32%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 276 YLDMTDCFVLEDEGLH--TIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKE 328
+L ++ C+ + D GL T+ L HL L C+ +T GL+ LV C S+ +
Sbjct: 602 FLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLND 656
>gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]
Length = 843
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 34 AQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPP 93
A+++ +++S +R + CP + G+STS++ G H
Sbjct: 3 AEESGPGAQNSPYQLRRKTLLPKRTACPTK----NSMEGASTSTTENFG------HRAKR 52
Query: 94 TRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRL 153
R++ L++ P EQ ++LPD +++IFS+L LCR A VC+R+ LA DP L
Sbjct: 53 ARVSGKSQDLSAAPA-EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPIL 111
Query: 154 WRTI 157
W+ +
Sbjct: 112 WKRL 115
>gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens]
Length = 686
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 34 AQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPP 93
A+++ +++S +R + CP + G+STS++ G H
Sbjct: 3 AEESGPGAQNSPYQLRRKTLLPKRTACPTK----NSMEGASTSTTENFG------HRAKR 52
Query: 94 TRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRL 153
R++ L++ P EQ ++LPD +++IFS+L LCR A VC+R+ LA DP L
Sbjct: 53 ARVSGKSQDLSAAPA-EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPIL 111
Query: 154 WRTI 157
W+ +
Sbjct: 112 WKRL 115
>gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens]
Length = 585
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 34 AQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPP 93
A+++ +++S +R + CP + G+STS++ G H
Sbjct: 3 AEESGPGAQNSPYQLRRKTLLPKRTACPTK----NSMEGASTSTTENFG------HRAKR 52
Query: 94 TRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRL 153
R++ L++ P EQ ++LPD +++IFS+L LCR A VC+R+ LA DP L
Sbjct: 53 ARVSGKSQDLSAAPA-EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPIL 111
Query: 154 WRTI 157
W+ +
Sbjct: 112 WKRL 115
>gi|27312027 F-box only protein 16 [Homo sapiens]
Length = 292
Score = 43.1 bits (100), Expect = 6e-04
Identities = 20/39 (51%), Positives = 24/39 (61%)
Query: 116 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 154
+LP + IFSFL LCRCA+VC W NLA +LW
Sbjct: 91 KLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLW 129
>gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [Homo
sapiens]
Length = 532
Score = 42.0 bits (97), Expect = 0.001
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 83 ETVAMVHSPPPTRLTHPLIRLASRPQKEQASID----RLPDHSMVQIFSFLPTNQLCRCA 138
E +A +P R R A RP+ E + +LP + IF +L +L RCA
Sbjct: 15 EELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKELGRCA 74
Query: 139 RVCRRWYNLAWDPRLW 154
+V + W +A D LW
Sbjct: 75 QVSKTWKVIAEDEVLW 90
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 87 MVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYN 146
++ S PT++ H + + PQ ++ I LP + + SFL L + A+ CR W
Sbjct: 138 LIDSCEPTQVKHMMQVI--EPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 195
Query: 147 LAWDPRLWR 155
LA D LWR
Sbjct: 196 LAEDNLLWR 204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,863,657
Number of Sequences: 37866
Number of extensions: 845513
Number of successful extensions: 4047
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 3148
Number of HSP's gapped (non-prelim): 552
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.