Search of human proteins with 66773344

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66773344 hypothetical protein LOC140710 [Homo sapiens]
         (1016 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66773344 hypothetical protein LOC140710 [Homo sapiens]            1998   0.0  
gi|163644316 hypothetical protein LOC23255 [Homo sapiens]             601   e-171
gi|59806361 hypothetical protein LOC387104 [Homo sapiens]             418   e-116
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           86   1e-16
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           86   1e-16
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           86   1e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     84   7e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         81   4e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        81   4e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        81   4e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         81   4e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         81   4e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         81   4e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         81   4e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         81   4e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         81   4e-15
gi|21735548 centrosomal protein 2 [Homo sapiens]                       80   7e-15
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    79   3e-14
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    78   4e-14
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                78   4e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    76   1e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    76   1e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    76   1e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    76   1e-13
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    76   2e-13
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               75   2e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    75   4e-13
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    74   5e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    73   2e-12
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  72   2e-12

>gi|66773344 hypothetical protein LOC140710 [Homo sapiens]
          Length = 1016

 Score = 1998 bits (5176), Expect = 0.0
 Identities = 1016/1016 (100%), Positives = 1016/1016 (100%)

Query: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG 60
            MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG
Sbjct: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG 60

Query: 61   LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH 120
            LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH
Sbjct: 61   LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH 120

Query: 121  SLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK 180
            SLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK
Sbjct: 121  SLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK 180

Query: 181  YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM
Sbjct: 181  YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
            DDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK
Sbjct: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300

Query: 301  LLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLL 360
            LLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLL
Sbjct: 301  LLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLL 360

Query: 361  SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLRE 420
            SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLRE
Sbjct: 361  SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLRE 420

Query: 421  QAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLS 480
            QAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLS
Sbjct: 421  QAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLS 480

Query: 481  VLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRD 540
            VLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRD
Sbjct: 481  VLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRD 540

Query: 541  LPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQ 600
            LPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQ
Sbjct: 541  LPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQ 600

Query: 601  EQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNML 660
            EQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNML
Sbjct: 601  EQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNML 660

Query: 661  VQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQH 720
            VQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQH
Sbjct: 661  VQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQH 720

Query: 721  SDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWET 780
            SDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWET
Sbjct: 721  SDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWET 780

Query: 781  ERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQIS 840
            ERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQIS
Sbjct: 781  ERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQIS 840

Query: 841  ERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKET 900
            ERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKET
Sbjct: 841  ERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKET 900

Query: 901  RSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFG 960
            RSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFG
Sbjct: 901  RSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFG 960

Query: 961  FVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGSQKLPFLLILAPPQPPPIL 1016
            FVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGSQKLPFLLILAPPQPPPIL
Sbjct: 961  FVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGSQKLPFLLILAPPQPPPIL 1016


>gi|163644316 hypothetical protein LOC23255 [Homo sapiens]
          Length = 1586

 Score =  601 bits (1549), Expect = e-171
 Identities = 394/973 (40%), Positives = 553/973 (56%), Gaps = 104/973 (10%)

Query: 1   MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG 60
           M EMRD Y+EEDVYQLQELR++LD+A+K CRILQYRLRKAE++SL+ A+TGQVDGELIR 
Sbjct: 1   MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60

Query: 61  LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH 120
           LEQD+KV+KD+S+RLH EL+ VE+KRA+ E+ENE LRQ++IE E++KQ LQ ELER +E 
Sbjct: 61  LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES 120

Query: 121 SLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK 180
           SLK+R TR + K +KKT  Q+DSADL+CQL FAKEE+ LM KK+ KL +E D +++EL K
Sbjct: 121 SLKRRSTREMYK-EKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQK 179

Query: 181 YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
           Y+SLYGD+DS L   E    P +RE ELK+ LKLVEEEAN+L R+IVELEVENRGL+AEM
Sbjct: 180 YKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEM 239

Query: 241 DDMKDHGGGCG-GPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQN 299
           +DM+      G G +   +      G+  ES  ELRRHLQFVEEEAELLRRS +E+ED N
Sbjct: 240 EDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHN 299

Query: 300 KLLLNELAKFRSEHELDVALSEDSCSVLS---EPSQEELAAAKLQIGELSGKVKKLQYEN 356
           + L +EL+KF+ E   +     +  S  +    P QEEL +A+LQI ELSGKV KLQ+EN
Sbjct: 300 RQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHEN 359

Query: 357 RVLLSNLQRCDLASCQSTRPMLETDAEAGDSA---------QCVPAPL------------ 395
             LLSN+QRCDLA+    R     D++A   A           +P P             
Sbjct: 360 HALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSE 419

Query: 396 --------------GETHESHAVRLCRARE-AEVLPGLREQAALVSKAIDVLVADANGFT 440
                          E  E     L +ARE +E L  L+ +A  + + ++ L+ D + F 
Sbjct: 420 EMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFL 479

Query: 441 AGLRLCLDNECADFRLHEAPDNSEG-PRDTKLIHAILVRLSVLQQELNAFTRKADAV-LG 498
               L          L    +  EG  ++ +L+  I  ++   ++EL AF  + + +  G
Sbjct: 480 HDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDG 539

Query: 499 CS-VKEQQESFSSLPPLGSQGLSKEI-LLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
            S +    ES S L  + S      I  L K+LG D Q            R++E      
Sbjct: 540 LSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQ-----------SRLKEQLEWQL 588

Query: 557 LDSKPDPSRSFR------PYRAEDNDSYASEIK-----ELQL----VLAEAHDSLRGLQE 601
             ++ D   S R       +R  D D+ +  +       L+L    VL E   S+  LQ 
Sbjct: 589 GPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQG 648

Query: 602 QLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLV 661
           QL Q  +L +EE + F  K+ +++E+   AL  +E E+ SL+LQ  L ++ WS EKN++ 
Sbjct: 649 QLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQ 708

Query: 662 QESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLE------VNSMKELYLLMEEEE 715
           QE +  K N  L ++KLRW LK WRQGK +  EG++F E      ++ + EL +    + 
Sbjct: 709 QELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQA 768

Query: 716 INAQHSDNKACTGDSWTQNTPNEYI-------------------------KTLADMKVTL 750
               H  ++ C G    +++P+  +                         +  +  K  L
Sbjct: 769 DGPDHDSDRGC-GFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALL 827

Query: 751 KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGE-RAGPDWK 809
           ++    LR++ R    LQQQ+A  KA W+ E A LK    Q+E KT    GE  +  + K
Sbjct: 828 EDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESK 887

Query: 810 AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKEL 869
            AL++ERE  Q LLA+S+S VM+L  Q+  SE+NW++EK++L++RL  ++Q+ E+Q KE 
Sbjct: 888 GALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEF 947

Query: 870 QNRLSQLQKAADP 882
             R+ QLQK   P
Sbjct: 948 LWRIEQLQKENSP 960


>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
          Length = 947

 Score =  418 bits (1075), Expect = e-116
 Identities = 251/544 (46%), Positives = 338/544 (62%), Gaps = 47/544 (8%)

Query: 1   MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG 60
           M EMRD + EED  QLQE+R +L++A+K CRILQYRLRKAER+ LR AQTG++DGEL+R 
Sbjct: 377 MDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRS 436

Query: 61  LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH 120
           LEQD+KV+KD+S+RLH ELE VE+KR   E+ENE+LRQ+LIE E+AKQ LQ ELE+ +E 
Sbjct: 437 LEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKEL 496

Query: 121 SLKKRGTRSLGKADKK---TLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEE 177
           SLK+RG++ L K++KK   T  +ED+ DLKCQL F KEE+ALM KK+ K+ KE D  + E
Sbjct: 497 SLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHE 556

Query: 178 LLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLR 237
           L KYRS YGDLDS L   E    P +RE ELK+ L+LVEEEAN+L R+IVELEVENRGL+
Sbjct: 557 LQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLK 616

Query: 238 AEMDDMK-DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE 296
           AE+DD++ D   G   P  R         E  ESL+ELR+HLQ VE+E ELLRR+ A+LE
Sbjct: 617 AELDDLRGDDFNGSANPLMR---------EQSESLSELRQHLQLVEDETELLRRNVADLE 667

Query: 297 DQNKLLLNELAKFR-SEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYE 355
           +QNK +  EL K++      D A   D+    +E  QEEL AA+LQI ELSGKV +LQYE
Sbjct: 668 EQNKRITAELNKYKYKSGGHDSARHHDNAK--TEALQEELKAARLQINELSGKVMQLQYE 725

Query: 356 NRVLLSNLQRCDLAS------------CQSTRPMLETDAEAGDSAQCVPAPLGETHESHA 403
           NRVL+SN+QR DLAS             +S     E+D ++    +    P+G   +S  
Sbjct: 726 NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGESDSEE 785

Query: 404 VRLCRA------------------REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRL 445
           VR  R                    + + +  +R +A  + K ID L+AD +      R+
Sbjct: 786 VRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTIITEARI 845

Query: 446 CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQ 505
            + N    F L +  D+    R+ +L++ I  ++   ++EL  F  + +       +  +
Sbjct: 846 YVANGDL-FGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADDRGAE 904

Query: 506 ESFS 509
           E  S
Sbjct: 905 EPIS 908



 Score = 37.0 bits (84), Expect = 0.094
 Identities = 27/104 (25%), Positives = 51/104 (49%), Gaps = 5/104 (4%)

Query: 252 GPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRS 311
           GP+     SA GGG    +    + H Q ++E+ E+ +    +L ++N+ L NE+ + R+
Sbjct: 317 GPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEM-QEEMEKLREENETLKNEIDELRT 375

Query: 312 EHE--LDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQ 353
           E +   D    ED+C +  +  + EL  A      L  +++K +
Sbjct: 376 EMDEMRDTFFEEDACQL--QEMRHELERANKNCRILQYRLRKAE 417


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 209/990 (21%), Positives = 404/990 (40%), Gaps = 123/990 (12%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK 69
            EED+  L++   +L   SK  ++L+ RL  AE  S  A +  +V       L+ +  ++ 
Sbjct: 1009 EEDLLLLEDQNSKL---SKERKLLEDRL--AEFSSQAAEEEEKVKSLNKLRLKYEATIA- 1062

Query: 70   DISMRLHKE---LEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRG 126
            D+  RL KE    + +EK + RL+ E+ EL+++++E +   + L+ +L R +E  L+   
Sbjct: 1063 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAAL 1121

Query: 127  TRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYR-SLY 185
             R+  +   +  + +   + +  L  A+E+        TK  K+   + EEL   R  L 
Sbjct: 1122 ARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1181

Query: 186  GDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKD 245
              LDS  + +EL        TELK   K +EEE  +    + EL   +     E+ +  +
Sbjct: 1182 DTLDSTNAQQELRSKREQEVTELK---KTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1238

Query: 246  HG--GGCGGPEARLAFSALGGGECGESLAEL---------------RRHLQFVE------ 282
                G     + RLA  A    E  E  AEL               R  LQ  E      
Sbjct: 1239 QARRGKGAWEKTRLALEA----EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1294

Query: 283  -------EEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEEL 335
                   E AE L+R+ AELE+ +   LNE          +++ +E       E  QEE 
Sbjct: 1295 DGERARAEAAEKLQRAQAELENVSG-ALNEAESKTIRLSKELSSTEAQLHDAQELLQEE- 1352

Query: 336  AAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPL 395
              AKL +G    +V+ ++ E   L   L+    A  ++ R +    A+  +  +      
Sbjct: 1353 TRAKLALG---SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1409

Query: 396  GETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            G        R   AREAE    L ++ A  ++ +D L                 E    R
Sbjct: 1410 GALEAGEEARRRAAREAE---ALTQRLAEKTETVDRL-----------------ERGRRR 1449

Query: 456  LHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLG 515
            L +  D  +   D +    ++  L   Q++ +    +  A +  +V+E++ + +     G
Sbjct: 1450 LQQELD--DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE----G 1503

Query: 516  SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSF----RPYR 571
             +  ++ + L + L  +    + R+  E + R   A     L SK D  +S     R  R
Sbjct: 1504 REREARALSLTRALEEE---QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACR 1560

Query: 572  AEDN--DSYASEIKELQLVLAEAHD-------SLRGLQEQLSQERQLRKEEADNFNQKMV 622
              +   +   +++ EL+  L  A D       +++ L+ Q  ++ Q R E  +   +++ 
Sbjct: 1561 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1620

Query: 623  -QLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
             QL++ +      R+    +++ +++LE +   +E    +  + Q K   +    K++  
Sbjct: 1621 KQLRDAEVERDEERKQRTLAVAARKKLEGEL--EELKAQMASAGQGKEEAVKQLRKMQAQ 1678

Query: 682  LKR-WRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNTPNEY 739
            +K  WR+ +   +  ++    N   E  L  +E E +  Q     +       Q   +E 
Sbjct: 1679 MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1738

Query: 740  IKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKG 799
               +A+  ++   +    R     L +L+++  + ++  E      +    Q+E  T + 
Sbjct: 1739 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTEL 1798

Query: 800  AGERA----GPDWKAALQREREEQQHLLAESYS--------AVMELTRQLQISERNWSQE 847
            + ER+        +  L+R+ +E +  L E  +         +  L  +L  +E    QE
Sbjct: 1799 SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE 1858

Query: 848  KLQLVERLQGE-KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH 906
              + +  L G+  ++ E+++KE+  ++ + ++ AD       +LEK +   K+ + +   
Sbjct: 1859 TRERI--LSGKLVRRAEKRLKEVVLQVEEERRVADQ---LRDQLEKGNLRVKQLKRQLEE 1913

Query: 907  DKEAVSEVELGGNGLKR-----TKSVSSMS 931
             +E  S  + G   L+R     T+S  SM+
Sbjct: 1914 AEEEASRAQAGRRRLQRELEDVTESAESMN 1943



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 212/1009 (21%), Positives = 399/1009 (39%), Gaps = 155/1009 (15%)

Query: 5    RDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQD 64
            +D  ++    +LQ++++   Q+++    LQ R+ + E    R A+  + + EL    E+ 
Sbjct: 875  QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE- 933

Query: 65   VKVSKDISMRLHKELE-VVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLK 123
               ++       +ELE VV +  AR+ EE E  RQ           +QTE +R ++H ++
Sbjct: 934  ---TRGRLAARKQELELVVSELEARVGEEEECSRQ-----------MQTEKKRLQQH-IQ 978

Query: 124  KRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL----- 178
            +       +   +  +Q +    + ++   +E+  L+  + +KL+KE   +++ L     
Sbjct: 979  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038

Query: 179  ----------------LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLL 222
                            LKY +   D++  L  EE          EL+   + ++ E++ L
Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEE------KGRQELEKLKRRLDGESSEL 1092

Query: 223  SRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG---ECGESLAELRRHLQ 279
              ++VE +     LRA++   ++        +A LA +   GG   +  +SL E +  L 
Sbjct: 1093 QEQMVEQQQRAEELRAQLGRKEEE------LQAALARAEDEGGARAQLLKSLREAQAALA 1146

Query: 280  FVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAK 339
              +E+ E  R +  + E Q + L  EL   R E E D   S ++   L    ++E+   K
Sbjct: 1147 EAQEDLESERVARTKAEKQRRDLGEELEALRGELE-DTLDSTNAQQELRSKREQEVTELK 1205

Query: 340  LQIGELS----GKVKKLQYENRVLLSNL------QRCDLASCQSTRPMLETDAEAGDSAQ 389
              + E +      V++L+  +   L  L       R    + + TR  LE +        
Sbjct: 1206 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSE----- 1260

Query: 390  CVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDN 449
             + A L     +      R R  E+     +   +  +A D   A A       R   + 
Sbjct: 1261 -LRAELSSLQTARQEGEQRRRRLEL-----QLQEVQGRAGDGERARAEAAEKLQRAQAEL 1314

Query: 450  ECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFS 509
            E     L+EA   S+  R +K + +   +L   Q+ L   TR A   LG  V+  +   +
Sbjct: 1315 ENVSGALNEA--ESKTIRLSKELSSTEAQLHDAQELLQEETR-AKLALGSRVRAMEAEAA 1371

Query: 510  SLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRP 569
             L     + L +E    +  G + Q      L EW  R R+    G L++  +  R    
Sbjct: 1372 GL----REQLEEEAAARERAGRELQTAQ-AQLSEW--RRRQEEEAGALEAGEEARRR--- 1421

Query: 570  YRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQ-------LSQERQLRKEEADNFNQKMV 622
              A + ++    + E    +       R LQ++       L Q+RQL     +   +K  
Sbjct: 1422 -AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL-VSTLEKKQRKFD 1479

Query: 623  QLKEDQQRALLR------------REFELQSLSLQRRLEQKFWSQEK------------N 658
            QL  +++ A+LR            RE E ++LSL R LE++  ++E+             
Sbjct: 1480 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1539

Query: 659  MLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINA 718
             L+        +   L    R   +     +   +E +D L      +L L +  + +  
Sbjct: 1540 ALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1599

Query: 719  QHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKE------LCWLLRDERRG-LTELQQQF 771
            QH +      D   +    +  K L D +V   E      L    R +  G L EL+ Q 
Sbjct: 1600 QH-ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1658

Query: 772  AKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVM 831
            A A    E    +L+   +QM+    +    R   +   +  RE E++   L    + V+
Sbjct: 1659 ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR---LKGLEAEVL 1715

Query: 832  ELTRQLQISE---RNWSQEKLQLVERLQG---EKQQVEQQVKELQNRLSQLQKAADPWVL 885
             L  +L  S+   R   Q++ ++ + +      K  + ++ ++L+ RL QL++       
Sbjct: 1716 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE------- 1768

Query: 886  KHSELEKQDNSWKETRSEKIHD--KEAVSEVELGGNGLKRTKSVSSMSE 932
               ELE++     ++ SE ++D  ++ + +VE     L   +S S+ +E
Sbjct: 1769 ---ELEEE-----QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1809



 Score = 30.4 bits (67), Expect = 8.8
 Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)

Query: 810 AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKEL 869
           AA  + R  Q   L      ++++TRQ ++ +     ++LQ V+ LQ   QQ  ++V EL
Sbjct: 849 AAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR--AQELQKVQELQ---QQSAREVGEL 903

Query: 870 QNRLSQLQK 878
           Q R++QL++
Sbjct: 904 QGRVAQLEE 912


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 209/990 (21%), Positives = 404/990 (40%), Gaps = 123/990 (12%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK 69
            EED+  L++   +L   SK  ++L+ RL  AE  S  A +  +V       L+ +  ++ 
Sbjct: 1001 EEDLLLLEDQNSKL---SKERKLLEDRL--AEFSSQAAEEEEKVKSLNKLRLKYEATIA- 1054

Query: 70   DISMRLHKE---LEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRG 126
            D+  RL KE    + +EK + RL+ E+ EL+++++E +   + L+ +L R +E  L+   
Sbjct: 1055 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAAL 1113

Query: 127  TRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYR-SLY 185
             R+  +   +  + +   + +  L  A+E+        TK  K+   + EEL   R  L 
Sbjct: 1114 ARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1173

Query: 186  GDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKD 245
              LDS  + +EL        TELK   K +EEE  +    + EL   +     E+ +  +
Sbjct: 1174 DTLDSTNAQQELRSKREQEVTELK---KTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1230

Query: 246  HG--GGCGGPEARLAFSALGGGECGESLAEL---------------RRHLQFVE------ 282
                G     + RLA  A    E  E  AEL               R  LQ  E      
Sbjct: 1231 QARRGKGAWEKTRLALEA----EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1286

Query: 283  -------EEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEEL 335
                   E AE L+R+ AELE+ +   LNE          +++ +E       E  QEE 
Sbjct: 1287 DGERARAEAAEKLQRAQAELENVSG-ALNEAESKTIRLSKELSSTEAQLHDAQELLQEE- 1344

Query: 336  AAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPL 395
              AKL +G    +V+ ++ E   L   L+    A  ++ R +    A+  +  +      
Sbjct: 1345 TRAKLALG---SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1401

Query: 396  GETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            G        R   AREAE    L ++ A  ++ +D L                 E    R
Sbjct: 1402 GALEAGEEARRRAAREAE---ALTQRLAEKTETVDRL-----------------ERGRRR 1441

Query: 456  LHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLG 515
            L +  D  +   D +    ++  L   Q++ +    +  A +  +V+E++ + +     G
Sbjct: 1442 LQQELD--DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE----G 1495

Query: 516  SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSF----RPYR 571
             +  ++ + L + L  +    + R+  E + R   A     L SK D  +S     R  R
Sbjct: 1496 REREARALSLTRALEEE---QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACR 1552

Query: 572  AEDN--DSYASEIKELQLVLAEAHD-------SLRGLQEQLSQERQLRKEEADNFNQKMV 622
              +   +   +++ EL+  L  A D       +++ L+ Q  ++ Q R E  +   +++ 
Sbjct: 1553 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1612

Query: 623  -QLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
             QL++ +      R+    +++ +++LE +   +E    +  + Q K   +    K++  
Sbjct: 1613 KQLRDAEVERDEERKQRTLAVAARKKLEGEL--EELKAQMASAGQGKEEAVKQLRKMQAQ 1670

Query: 682  LKR-WRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNTPNEY 739
            +K  WR+ +   +  ++    N   E  L  +E E +  Q     +       Q   +E 
Sbjct: 1671 MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1730

Query: 740  IKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKG 799
               +A+  ++   +    R     L +L+++  + ++  E      +    Q+E  T + 
Sbjct: 1731 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTEL 1790

Query: 800  AGERA----GPDWKAALQREREEQQHLLAESYS--------AVMELTRQLQISERNWSQE 847
            + ER+        +  L+R+ +E +  L E  +         +  L  +L  +E    QE
Sbjct: 1791 SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE 1850

Query: 848  KLQLVERLQGE-KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH 906
              + +  L G+  ++ E+++KE+  ++ + ++ AD       +LEK +   K+ + +   
Sbjct: 1851 TRERI--LSGKLVRRAEKRLKEVVLQVEEERRVADQ---LRDQLEKGNLRVKQLKRQLEE 1905

Query: 907  DKEAVSEVELGGNGLKR-----TKSVSSMS 931
             +E  S  + G   L+R     T+S  SM+
Sbjct: 1906 AEEEASRAQAGRRRLQRELEDVTESAESMN 1935



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 212/1009 (21%), Positives = 399/1009 (39%), Gaps = 155/1009 (15%)

Query: 5    RDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQD 64
            +D  ++    +LQ++++   Q+++    LQ R+ + E    R A+  + + EL    E+ 
Sbjct: 867  QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE- 925

Query: 65   VKVSKDISMRLHKELE-VVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLK 123
               ++       +ELE VV +  AR+ EE E  RQ           +QTE +R ++H ++
Sbjct: 926  ---TRGRLAARKQELELVVSELEARVGEEEECSRQ-----------MQTEKKRLQQH-IQ 970

Query: 124  KRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL----- 178
            +       +   +  +Q +    + ++   +E+  L+  + +KL+KE   +++ L     
Sbjct: 971  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030

Query: 179  ----------------LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLL 222
                            LKY +   D++  L  EE          EL+   + ++ E++ L
Sbjct: 1031 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEE------KGRQELEKLKRRLDGESSEL 1084

Query: 223  SRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG---ECGESLAELRRHLQ 279
              ++VE +     LRA++   ++        +A LA +   GG   +  +SL E +  L 
Sbjct: 1085 QEQMVEQQQRAEELRAQLGRKEEE------LQAALARAEDEGGARAQLLKSLREAQAALA 1138

Query: 280  FVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAK 339
              +E+ E  R +  + E Q + L  EL   R E E D   S ++   L    ++E+   K
Sbjct: 1139 EAQEDLESERVARTKAEKQRRDLGEELEALRGELE-DTLDSTNAQQELRSKREQEVTELK 1197

Query: 340  LQIGELS----GKVKKLQYENRVLLSNL------QRCDLASCQSTRPMLETDAEAGDSAQ 389
              + E +      V++L+  +   L  L       R    + + TR  LE +        
Sbjct: 1198 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSE----- 1252

Query: 390  CVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDN 449
             + A L     +      R R  E+     +   +  +A D   A A       R   + 
Sbjct: 1253 -LRAELSSLQTARQEGEQRRRRLEL-----QLQEVQGRAGDGERARAEAAEKLQRAQAEL 1306

Query: 450  ECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFS 509
            E     L+EA   S+  R +K + +   +L   Q+ L   TR A   LG  V+  +   +
Sbjct: 1307 ENVSGALNEA--ESKTIRLSKELSSTEAQLHDAQELLQEETR-AKLALGSRVRAMEAEAA 1363

Query: 510  SLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRP 569
             L     + L +E    +  G + Q      L EW  R R+    G L++  +  R    
Sbjct: 1364 GL----REQLEEEAAARERAGRELQTAQ-AQLSEW--RRRQEEEAGALEAGEEARRR--- 1413

Query: 570  YRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQ-------LSQERQLRKEEADNFNQKMV 622
              A + ++    + E    +       R LQ++       L Q+RQL     +   +K  
Sbjct: 1414 -AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL-VSTLEKKQRKFD 1471

Query: 623  QLKEDQQRALLR------------REFELQSLSLQRRLEQKFWSQEK------------N 658
            QL  +++ A+LR            RE E ++LSL R LE++  ++E+             
Sbjct: 1472 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1531

Query: 659  MLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINA 718
             L+        +   L    R   +     +   +E +D L      +L L +  + +  
Sbjct: 1532 ALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1591

Query: 719  QHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKE------LCWLLRDERRG-LTELQQQF 771
            QH +      D   +    +  K L D +V   E      L    R +  G L EL+ Q 
Sbjct: 1592 QH-ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1650

Query: 772  AKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVM 831
            A A    E    +L+   +QM+    +    R   +   +  RE E++   L    + V+
Sbjct: 1651 ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR---LKGLEAEVL 1707

Query: 832  ELTRQLQISE---RNWSQEKLQLVERLQG---EKQQVEQQVKELQNRLSQLQKAADPWVL 885
             L  +L  S+   R   Q++ ++ + +      K  + ++ ++L+ RL QL++       
Sbjct: 1708 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE------- 1760

Query: 886  KHSELEKQDNSWKETRSEKIHD--KEAVSEVELGGNGLKRTKSVSSMSE 932
               ELE++     ++ SE ++D  ++ + +VE     L   +S S+ +E
Sbjct: 1761 ---ELEEE-----QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1801



 Score = 30.4 bits (67), Expect = 8.8
 Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)

Query: 810 AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKEL 869
           AA  + R  Q   L      ++++TRQ ++ +     ++LQ V+ LQ   QQ  ++V EL
Sbjct: 841 AAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR--AQELQKVQELQ---QQSAREVGEL 895

Query: 870 QNRLSQLQK 878
           Q R++QL++
Sbjct: 896 QGRVAQLEE 904


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 209/990 (21%), Positives = 404/990 (40%), Gaps = 123/990 (12%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK 69
            EED+  L++   +L   SK  ++L+ RL  AE  S  A +  +V       L+ +  ++ 
Sbjct: 1042 EEDLLLLEDQNSKL---SKERKLLEDRL--AEFSSQAAEEEEKVKSLNKLRLKYEATIA- 1095

Query: 70   DISMRLHKE---LEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRG 126
            D+  RL KE    + +EK + RL+ E+ EL+++++E +   + L+ +L R +E  L+   
Sbjct: 1096 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAAL 1154

Query: 127  TRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYR-SLY 185
             R+  +   +  + +   + +  L  A+E+        TK  K+   + EEL   R  L 
Sbjct: 1155 ARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELE 1214

Query: 186  GDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKD 245
              LDS  + +EL        TELK   K +EEE  +    + EL   +     E+ +  +
Sbjct: 1215 DTLDSTNAQQELRSKREQEVTELK---KTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1271

Query: 246  HG--GGCGGPEARLAFSALGGGECGESLAEL---------------RRHLQFVE------ 282
                G     + RLA  A    E  E  AEL               R  LQ  E      
Sbjct: 1272 QARRGKGAWEKTRLALEA----EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1327

Query: 283  -------EEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEEL 335
                   E AE L+R+ AELE+ +   LNE          +++ +E       E  QEE 
Sbjct: 1328 DGERARAEAAEKLQRAQAELENVSG-ALNEAESKTIRLSKELSSTEAQLHDAQELLQEE- 1385

Query: 336  AAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPL 395
              AKL +G    +V+ ++ E   L   L+    A  ++ R +    A+  +  +      
Sbjct: 1386 TRAKLALG---SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1442

Query: 396  GETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            G        R   AREAE    L ++ A  ++ +D L                 E    R
Sbjct: 1443 GALEAGEEARRRAAREAE---ALTQRLAEKTETVDRL-----------------ERGRRR 1482

Query: 456  LHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLG 515
            L +  D  +   D +    ++  L   Q++ +    +  A +  +V+E++ + +     G
Sbjct: 1483 LQQELD--DATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE----G 1536

Query: 516  SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSF----RPYR 571
             +  ++ + L + L  +    + R+  E + R   A     L SK D  +S     R  R
Sbjct: 1537 REREARALSLTRALEEE---QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACR 1593

Query: 572  AEDN--DSYASEIKELQLVLAEAHD-------SLRGLQEQLSQERQLRKEEADNFNQKMV 622
              +   +   +++ EL+  L  A D       +++ L+ Q  ++ Q R E  +   +++ 
Sbjct: 1594 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1653

Query: 623  -QLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
             QL++ +      R+    +++ +++LE +   +E    +  + Q K   +    K++  
Sbjct: 1654 KQLRDAEVERDEERKQRTLAVAARKKLEGEL--EELKAQMASAGQGKEEAVKQLRKMQAQ 1711

Query: 682  LKR-WRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNTPNEY 739
            +K  WR+ +   +  ++    N   E  L  +E E +  Q     +       Q   +E 
Sbjct: 1712 MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1771

Query: 740  IKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKG 799
               +A+  ++   +    R     L +L+++  + ++  E      +    Q+E  T + 
Sbjct: 1772 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTEL 1831

Query: 800  AGERA----GPDWKAALQREREEQQHLLAESYS--------AVMELTRQLQISERNWSQE 847
            + ER+        +  L+R+ +E +  L E  +         +  L  +L  +E    QE
Sbjct: 1832 SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE 1891

Query: 848  KLQLVERLQGE-KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH 906
              + +  L G+  ++ E+++KE+  ++ + ++ AD       +LEK +   K+ + +   
Sbjct: 1892 TRERI--LSGKLVRRAEKRLKEVVLQVEEERRVADQ---LRDQLEKGNLRVKQLKRQLEE 1946

Query: 907  DKEAVSEVELGGNGLKR-----TKSVSSMS 931
             +E  S  + G   L+R     T+S  SM+
Sbjct: 1947 AEEEASRAQAGRRRLQRELEDVTESAESMN 1976



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 212/1009 (21%), Positives = 399/1009 (39%), Gaps = 155/1009 (15%)

Query: 5    RDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQD 64
            +D  ++    +LQ++++   Q+++    LQ R+ + E    R A+  + + EL    E+ 
Sbjct: 908  QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE- 966

Query: 65   VKVSKDISMRLHKELE-VVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLK 123
               ++       +ELE VV +  AR+ EE E  RQ           +QTE +R ++H ++
Sbjct: 967  ---TRGRLAARKQELELVVSELEARVGEEEECSRQ-----------MQTEKKRLQQH-IQ 1011

Query: 124  KRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL----- 178
            +       +   +  +Q +    + ++   +E+  L+  + +KL+KE   +++ L     
Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1071

Query: 179  ----------------LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLL 222
                            LKY +   D++  L  EE          EL+   + ++ E++ L
Sbjct: 1072 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEE------KGRQELEKLKRRLDGESSEL 1125

Query: 223  SRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG---ECGESLAELRRHLQ 279
              ++VE +     LRA++   ++        +A LA +   GG   +  +SL E +  L 
Sbjct: 1126 QEQMVEQQQRAEELRAQLGRKEEE------LQAALARAEDEGGARAQLLKSLREAQAALA 1179

Query: 280  FVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAK 339
              +E+ E  R +  + E Q + L  EL   R E E D   S ++   L    ++E+   K
Sbjct: 1180 EAQEDLESERVARTKAEKQRRDLGEELEALRGELE-DTLDSTNAQQELRSKREQEVTELK 1238

Query: 340  LQIGELS----GKVKKLQYENRVLLSNL------QRCDLASCQSTRPMLETDAEAGDSAQ 389
              + E +      V++L+  +   L  L       R    + + TR  LE +        
Sbjct: 1239 KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSE----- 1293

Query: 390  CVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDN 449
             + A L     +      R R  E+     +   +  +A D   A A       R   + 
Sbjct: 1294 -LRAELSSLQTARQEGEQRRRRLEL-----QLQEVQGRAGDGERARAEAAEKLQRAQAEL 1347

Query: 450  ECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFS 509
            E     L+EA   S+  R +K + +   +L   Q+ L   TR A   LG  V+  +   +
Sbjct: 1348 ENVSGALNEA--ESKTIRLSKELSSTEAQLHDAQELLQEETR-AKLALGSRVRAMEAEAA 1404

Query: 510  SLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRP 569
             L     + L +E    +  G + Q      L EW  R R+    G L++  +  R    
Sbjct: 1405 GL----REQLEEEAAARERAGRELQTAQ-AQLSEW--RRRQEEEAGALEAGEEARRR--- 1454

Query: 570  YRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQ-------LSQERQLRKEEADNFNQKMV 622
              A + ++    + E    +       R LQ++       L Q+RQL     +   +K  
Sbjct: 1455 -AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL-VSTLEKKQRKFD 1512

Query: 623  QLKEDQQRALLR------------REFELQSLSLQRRLEQKFWSQEK------------N 658
            QL  +++ A+LR            RE E ++LSL R LE++  ++E+             
Sbjct: 1513 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1572

Query: 659  MLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINA 718
             L+        +   L    R   +     +   +E +D L      +L L +  + +  
Sbjct: 1573 ALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1632

Query: 719  QHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKE------LCWLLRDERRG-LTELQQQF 771
            QH +      D   +    +  K L D +V   E      L    R +  G L EL+ Q 
Sbjct: 1633 QH-ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1691

Query: 772  AKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVM 831
            A A    E    +L+   +QM+    +    R   +   +  RE E++   L    + V+
Sbjct: 1692 ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR---LKGLEAEVL 1748

Query: 832  ELTRQLQISE---RNWSQEKLQLVERLQG---EKQQVEQQVKELQNRLSQLQKAADPWVL 885
             L  +L  S+   R   Q++ ++ + +      K  + ++ ++L+ RL QL++       
Sbjct: 1749 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE------- 1801

Query: 886  KHSELEKQDNSWKETRSEKIHD--KEAVSEVELGGNGLKRTKSVSSMSE 932
               ELE++     ++ SE ++D  ++ + +VE     L   +S S+ +E
Sbjct: 1802 ---ELEEE-----QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1842



 Score = 30.4 bits (67), Expect = 8.8
 Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 5/69 (7%)

Query: 810 AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKEL 869
           AA  + R  Q   L      ++++TRQ ++ +     ++LQ V+ LQ   QQ  ++V EL
Sbjct: 882 AAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR--AQELQKVQELQ---QQSAREVGEL 936

Query: 870 QNRLSQLQK 878
           Q R++QL++
Sbjct: 937 QGRVAQLEE 945


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 204/996 (20%), Positives = 408/996 (40%), Gaps = 143/996 (14%)

Query: 18   ELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDG--ELIRGLEQDVKVSKDISMRL 75
            +L++QL   ++ C         AE   LRA  T +     E+   LE  V+  ++    L
Sbjct: 884  QLQEQLQAETELC---------AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934

Query: 76   HKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADK 135
              E       + ++++  +EL ++L E E A+Q LQ E +   E  LKK         ++
Sbjct: 935  QAE-------KKKMQQNIQELEEQLEEEESARQKLQLE-KVTTEAKLKK-------LEEE 979

Query: 136  KTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAE 195
            + ++++ +  L  +    ++  A     LT+  +++ S+ +   K+ ++  DL+  L  E
Sbjct: 980  QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039

Query: 196  ELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEA 255
            E       +  EL+   + +E ++  LS +I EL+ +   L+ ++   ++         A
Sbjct: 1040 E------KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE---LQAALA 1090

Query: 256  RLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHE- 314
            R+   A       + + EL   +  ++E+ E  R S  + E Q + L  EL   ++E E 
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150

Query: 315  -LDVALS--------EDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQR 365
             LD   +        E   ++L +  +EE    + QI E+  K  +   E    L   +R
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210

Query: 366  CDLASCQSTRPMLETDAEAGDSAQCVPAPL-GETHESHAVRLCRAREAEVL----PGLRE 420
               A+ +  +  LE   E G+ A  V   L G+    H  +   A+  E+      G R 
Sbjct: 1211 VK-ANLEKAKQTLEN--ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267

Query: 421  QAALVSKA--IDVLVADANGF-----TAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIH 473
            +  L  K   + V + +  G      +   +L  D    + +L +  +  +     KL  
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL-- 1325

Query: 474  AILVRLSVLQQELNAFTRKAD-------------AVLGCSVKEQQESFSSLPPLGSQGLS 520
            ++  +L  ++ E N+F  + +             A L   V + ++       +G    +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED--SVGCLETA 1383

Query: 521  KEI--LLAKDLGSDFQPPD-----FRDLPEWEPRIREAF--RTGDLDSKPDPS------- 564
            +E+   L KDL    Q  +     +  L + + R+++       DLD +   +       
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443

Query: 565  RSFRPYRAEDNDSYASEIKELQLVLAEAHDS-------LRGLQEQLSQERQLRK--EEAD 615
            + F    AE+    A   +E     AEA +         R L+E + Q+ +L +  ++  
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503

Query: 616  NFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQ-KFWSQEKNMLVQESQQFKHNFLLL 674
               + ++  K+D  +++   E E    +L++++E+ K   +E    +Q ++  K    + 
Sbjct: 1504 TEMEDLMSSKDDVGKSV--HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561

Query: 675  FMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEE------------EINAQHSD 722
               ++   +R  QG+   SE      V  ++E+   +E+E            ++     D
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621

Query: 723  NKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETER 782
             +A   DS  +N  +E IK L  ++  +K+    L D R    E+    A+AK   E E+
Sbjct: 1622 LEAHI-DSANKNR-DEAIKQLRKLQAQMKDCMRELDDTRASREEI---LAQAK---ENEK 1673

Query: 783  AELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESY---SAVMELTRQLQI 839
                     ++L+    A ERA    K   Q+ER+E    +A S    +  +E  R+L+ 
Sbjct: 1674 KLKSMEAEMIQLQEELAAAERA----KRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729

Query: 840  SERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
                  +E    +E  QG  + +  ++K+   ++ Q+    +   L+ S  +K +N+ ++
Sbjct: 1730 RIAQLEEE----LEEEQGNTELINDRLKKANLQIDQINTDLN---LERSHAQKNENARQQ 1782

Query: 900  TRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFES 935
               +    K  + E+E    G  ++K  +S++  E+
Sbjct: 1783 LERQNKELKVKLQEME----GTVKSKYKASITALEA 1814



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 101/454 (22%), Positives = 185/454 (40%), Gaps = 89/454 (19%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISM- 73
            QLQEL+ + ++  +       R   A++ +    +   V G L +   +  K++KD S  
Sbjct: 1253 QLQELQVKFNEGERV------RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306

Query: 74   --RLHKELEVVEK----------KRARLEEENEELRQRLIETELAKQVLQTELE--RPRE 119
              +L    E++++          K  ++E+E    R++L E E AK  L+ ++     + 
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366

Query: 120  HSLKKRGTRSLG----KADKKTLVQEDSADLKCQLHFAKEESALMCKKL----TKLAKEN 171
              +KK+   S+G      + K  +Q+D   L  Q H   EE      KL    T+L +E 
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS-QRH---EEKVAAYDKLEKTKTRLQQEL 1422

Query: 172  DSMKEELLKYRSLYGDL-------DSALSAEELADAPHSRETELKVHLKLVEEEANLLS- 223
            D +  +L   R    +L       D  L+ E+   A ++ E + +   +  E+E   LS 
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD-RAEAEAREKETKALSL 1481

Query: 224  --------RRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELR 275
                     +  ELE  N+  R EM+D+                      + G+S+ EL 
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMS-----------------SKDDVGKSVHELE 1524

Query: 276  RHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDV--ALSEDSCSVLSEPSQE 333
            +  + +E++ E ++    ELED+  L   E AK R E  L    A  E       E S+E
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDE--LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582

Query: 334  ELAAAKLQIGELSGKV--------------KKLQYENRVLLSNLQRCDLASCQSTRPMLE 379
            +      Q+ E+  ++              KKL+ + + L +++   +    ++ + + +
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642

Query: 380  TDAEAGDSAQCVPAPLGETHESHAVRLCRAREAE 413
              A+  D  +     L +T  S    L +A+E E
Sbjct: 1643 LQAQMKDCMR----ELDDTRASREEILAQAKENE 1672



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/247 (22%), Positives = 99/247 (40%), Gaps = 29/247 (11%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK 69
            EE + Q +E  ++L         LQ  L  AER   +A Q      + I        ++ 
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721

Query: 70   DISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRS 129
            +   RL   +  +E++    +   E +  RL +  L    + T+L   R H+ K    R 
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ 1781

Query: 130  LGKADKK---------------------TLVQEDSADLKCQLHFAKEESALMCKKLTKLA 168
              +   K                     T ++   A L+ QL    +E    CK++ +  
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841

Query: 169  KENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANL--LSRRI 226
            K+   +K+ LL+   +  +  +A   ++ AD   +R  +LK  L+  EEEA     SRR 
Sbjct: 1842 KK---LKDVLLQ---VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRK 1895

Query: 227  VELEVEN 233
            ++ E+E+
Sbjct: 1896 LQRELED 1902



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 72/319 (22%), Positives = 125/319 (39%), Gaps = 47/319 (14%)

Query: 599  LQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLR-REFE-LQSLSLQRRLEQKFWSQE 656
            LQ    +E  + KEE      ++V+++E Q  A  R  E E LQS  +  +L+ +   Q 
Sbjct: 838  LQVSRQEEEMMAKEE------ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891

Query: 657  KNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEI 716
            +  L  E+++ +        +L               E    L+    K    + E EE 
Sbjct: 892  ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951

Query: 717  NAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA 776
              +         +S  Q    E + T A +K         L +E+  L +   + AK K 
Sbjct: 952  LEEE--------ESARQKLQLEKVTTEAKLKK--------LEEEQIILEDQNCKLAKEKK 995

Query: 777  TWETERAELKGHTSQMELKTG-----KGAGERAGPDWKAALQREREEQQHL--------- 822
              E   AE   + ++ E K+      K   E    D +  L+RE +++Q L         
Sbjct: 996  LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055

Query: 823  --------LAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLS 874
                    +AE  + + EL  QL   E    Q  L  VE    +K    ++++EL++++S
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEEL-QAALARVEEEAAQKNMALKKIRELESQIS 1114

Query: 875  QLQKAADPWVLKHSELEKQ 893
            +LQ+  +      ++ EKQ
Sbjct: 1115 ELQEDLESERASRNKAEKQ 1133



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 76/307 (24%), Positives = 122/307 (39%), Gaps = 48/307 (15%)

Query: 16   LQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRL 75
            L++L   +D A+K         R    + LR  Q    D   +R L+ D + S++  +  
Sbjct: 1619 LKDLEAHIDSANKN--------RDEAIKQLRKLQAQMKD--CMRELD-DTRASREEILAQ 1667

Query: 76   HKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADK 135
             KE E   KK   +E E  +L++ L   E AK+  Q E +   +      G  +L   +K
Sbjct: 1668 AKENE---KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724

Query: 136  KTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAE 195
            + L +   A L+ +L   +  + L+  +L K   + D +  +L   RS       A   E
Sbjct: 1725 RRL-EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS------HAQKNE 1777

Query: 196  ELADAPHSRETELKVHLKLVEEEANLLSR---RIVELEVENRGLRAEMD-DMKDHGGGCG 251
                    +  ELKV  KL E E  + S+    I  LE +   L  ++D + K+    C 
Sbjct: 1778 NARQQLERQNKELKV--KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACK 1835

Query: 252  G---PEARLAFSALG--------------GGECGESLAELRRHLQFVEEEAELL----RR 290
                 E +L    L                 +    L +L+R L+  EEEA+      R+
Sbjct: 1836 QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRK 1895

Query: 291  SSAELED 297
               ELED
Sbjct: 1896 LQRELED 1902



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 18/115 (15%)

Query: 809 KAALQREREEQQHLLAESYSAVMELTRQLQISERNWS------QEKLQLVERLQGEKQQV 862
           K  LQ + + +  L AE+      LT + Q  E          +E+ +  + LQ EK+++
Sbjct: 882 KLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKM 941

Query: 863 EQQVKELQNRLS---------QLQKAADPWVLKHSELEK---QDNSWKETRSEKI 905
           +Q ++EL+ +L          QL+K      LK  E E+   +D + K  + +K+
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 996


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 225/1050 (21%), Positives = 413/1050 (39%), Gaps = 189/1050 (18%)

Query: 16   LQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGEL---IRGLEQDVKVSK-DI 71
            ++  RQ+  +A      L+ +LR  ++++    +  Q   +L   ++ L++ +KV+K  +
Sbjct: 659  VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL 718

Query: 72   SMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLG 131
                 +  + +E+++  + E   E R  + + +  ++ L  E ER     L+ R  + LG
Sbjct: 719  EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKEL--EEERAGRKGLEAR-LQQLG 775

Query: 132  KADKKT--LVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLD 189
            +A +    +++ + A+     H A+ E   + K++    +  +  ++E  +Y +++ +  
Sbjct: 776  EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQL 835

Query: 190  SALSAE------ELADAP--------HSRETELKVHLKLVEEEANLLS--RRIVELEVEN 233
              L  E      EL +A         HS     +   +L E  ANL    +++ E EV  
Sbjct: 836  MTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRA 895

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSA 293
            + L  ++  +++         ARL       GE  E+ +      + V+E A    R   
Sbjct: 896  QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR-----ELVKEPARAGDRQPE 950

Query: 294  ELEDQN-----------KLLLNELAKFRSEHE-LDVALSEDSCSVLSEPSQEELAAAKL- 340
             LE+Q            + +  E  +  +E E L  AL E       E  Q+E   A+L 
Sbjct: 951  WLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLT 1010

Query: 341  ------QIGELSGKVKKLQYENRVLLS-NLQRCDLASCQSTRPMLETDAEAGDSAQCVPA 393
                  Q      K  + + E R+  + N QR + A+ Q       T+ E  D       
Sbjct: 1011 QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE----- 1065

Query: 394  PLGETHESHAVRLCRAREA-EVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECA 452
             L +     A ++    E  + +  L+EQ A   K        A+G  A           
Sbjct: 1066 -LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE------HASGSGAQ---------- 1108

Query: 453  DFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAV---LGCSVKEQQESFS 509
                 EA   +E P   KL  A+   +S L+Q+      +AD++   L      + E  S
Sbjct: 1109 ----SEAAGRTE-PTGPKL-EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDS 1162

Query: 510  SLPPLGSQGLSKEILLAKDLG--------SDFQPPDFRDL--------PEWEPRI----R 549
            +L  L  Q   K    A++LG        +  +   FR           EW+ ++    +
Sbjct: 1163 ALETLQGQLEEK----AQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218

Query: 550  EAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDS------LRGLQEQL 603
            EA R   L S  +   S    +  + +  + E+K  +LV+AE+  S      LR LQ + 
Sbjct: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESKELK--RLVMAESEKSQKLEERLRLLQAET 1276

Query: 604  SQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQ-----------RRLEQKF 652
            +       E +    +++  L+E+ ++  +  E   Q L+ Q           +  ++KF
Sbjct: 1277 ASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKF 1336

Query: 653  WSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLME 712
            + +E+ +   + +      L+  +     L +  Q +   +E     E+   K+    + 
Sbjct: 1337 FQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLR 1396

Query: 713  EEEINAQHS-------DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLT 765
             E + AQ           K    +   Q    E   + A+    LK+   LL +E RGL 
Sbjct: 1397 AELLRAQRELGELIPLRQKVAEQERTAQQLRAEKA-SYAEQLSMLKKAHGLLAEENRGLG 1455

Query: 766  ELQ-------------------QQFAKAKATWETERAELKGHTS----QMELKTGKGAGE 802
            E                     Q+ A  +A  ET  AE++        ++E+ T K  G 
Sbjct: 1456 ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGA 1515

Query: 803  RAGPDWKAALQRER--EEQQHLLA----------ESYSAVMELTRQLQISER--NWSQEK 848
            +     K   +R+R  EE+Q L A          E    V EL+++L  S++     Q+K
Sbjct: 1516 KV----KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK 1571

Query: 849  LQLVERLQGEKQQVEQ----QVKELQNRLSQLQKAADPWVLK------HSELEKQDNSWK 898
            L+ V+   GE QQ  Q    Q+ ELQ +LSQ ++AA+ + L+      H + +KQ N   
Sbjct: 1572 LKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQEL 1631

Query: 899  ETRSEKI-----HDKEAVSEVELGGNGLKR 923
            + +   +      +KE  +E E  G+ L++
Sbjct: 1632 QEQLRSLEQLQKENKELRAEAERLGHELQQ 1661



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 221/1019 (21%), Positives = 388/1019 (38%), Gaps = 149/1019 (14%)

Query: 14   YQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISM 73
            +Q++ L++QL  A +     +  L  AE R L   +  Q+     R     +   K  + 
Sbjct: 214  FQMRRLKKQL--ADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAAS 271

Query: 74   RLH-KELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGK 132
             L  KELE        L ++NE L  RL ET    Q L+TE         K +  R + +
Sbjct: 272  PLEPKELE-------ELRDKNESLTMRLHETLKQCQDLKTE---------KSQMDRKINQ 315

Query: 133  ADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELL-KYRSLYGDLDSA 191
                  + E++ DL  +L         +   L +L +E+    +E L K   L  +L +A
Sbjct: 316  ------LSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAA 369

Query: 192  LSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCG 251
            L  ++  +    +   L+  L  +EE  + L     + + E  G   +++ +K       
Sbjct: 370  LQDKKCLE---EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426

Query: 252  GPEARL-AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFR 310
                +L A   +   E G+  A+L       EEE + L     +L+      ++ L++ +
Sbjct: 427  ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS----ISNLSQAK 482

Query: 311  SEHEL-----DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQR 365
             E E         L+    S+ SE +    A  + Q  EL+G  ++ + +   L   LQ+
Sbjct: 483  EELEQASQAHGARLTAQVASLTSELTTLN-ATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541

Query: 366  CDLASCQSTRPMLETDAEAGDSAQCVPAPLGE----THESHAVRLCRAREAEVLPGLREQ 421
             + AS Q  R  +E  + +    +     + E    T + HA +L  A E E    LRE+
Sbjct: 542  QEQAS-QGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE-EREASLRER 599

Query: 422  AALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSV 481
             A + K ++ L  +       L+  L         +EA D+++              ++ 
Sbjct: 600  DAAL-KQLEALEKEKAAKLEILQQQLQ------VANEARDSAQ------------TSVTQ 640

Query: 482  LQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDL 541
             Q+E    +RK + +  C    +QE   +   +    L       K    +    +   L
Sbjct: 641  AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700

Query: 542  PEWEPRIREAFRT--GDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGL 599
             E    ++E+ +   G L+              E+    A  ++E Q  ++E     R L
Sbjct: 701  QEQLQALKESLKVTKGSLE--------------EEKRRAADALEEQQRCISELKAETRSL 746

Query: 600  QEQLSQERQLRKEE---ADNFNQKMVQLKEDQQ--RALLRREFELQSLSLQRRLEQK--- 651
             EQ  +ER+  +EE         ++ QL E  Q    +LRRE   ++++ Q   E +   
Sbjct: 747  VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL-AEAMAAQHTAESECEQ 805

Query: 652  ------FWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMK 705
                   W +      QE  Q+   F    M L+   ++ RQ   L    +    + S  
Sbjct: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQ--ELQEAKEKVAGIESHS 863

Query: 706  ELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKT--LADMKVTLKELCWLLRDERRG 763
            EL +  ++ E+   H++          Q    + ++   LAD   TL+E    +    + 
Sbjct: 864  ELQISRQQNELAELHANLARA-----LQQVQEKEVRAQKLADDLSTLQE---KMAATSKE 915

Query: 764  LTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDW------------KAA 811
            +  L+    KA    ET   EL        +K    AG+R  P+W            +AA
Sbjct: 916  VARLETLVRKAGEQQETASREL--------VKEPARAGDRQ-PEWLEEQQGRQFCSTQAA 966

Query: 812  LQ---REREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVER-------LQGEKQQ 861
            LQ   RE E+  + L    +A+ME   Q Q       +E  +L +        L  EK  
Sbjct: 967  LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026

Query: 862  VEQQVKELQNRLSQ--LQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEA--VSEVELG 917
              +    LQN L++  ++ A     L H+  EK+    K+    K+   EA  + E+E  
Sbjct: 1027 RAELEMRLQNALNEQRVEFATLQEALAHALTEKEG---KDQELAKLRGLEAAQIKELEEL 1083

Query: 918  GNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKDTKEK 976
               +K+ K   +  E E     S   A  +A G+  P  P    + +E    E+  +++
Sbjct: 1084 RQTVKQLKEQLAKKEKE---HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 205/1020 (20%), Positives = 395/1020 (38%), Gaps = 163/1020 (15%)

Query: 9    MEEDVYQLQELR-------QQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL 61
            + E + Q Q+L+       ++++Q S+    L ++LR+       A+   Q+   L    
Sbjct: 292  LHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREF------ASHLQQLQDALNELT 345

Query: 62   EQDVKVSKDI---SMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPR 118
            E+  K +++      +L KEL    + +  LEE+NE L+ +L +       L+  L + +
Sbjct: 346  EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQ-------LEEHLSQLQ 398

Query: 119  EHSLKKRGTRSLGKADKKTLVQE------DSADLKCQLHFAKEESALMCKKLTKLAKEND 172
            ++  +++G         +TL QE      ++  L+ ++   + E     ++  KL  E  
Sbjct: 399  DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG---QQEAKLLAERG 455

Query: 173  SMKEELLKYRSLYGDLDSALS-----AEELADAPHSRETELKVHLKLVEEEANLLSRRIV 227
              +EE  +  SL  DL S++S      EEL  A  +    L   +  +  E   L+  I 
Sbjct: 456  HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515

Query: 228  ELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAEL 287
            + + E  GL+ +  +           +A+LA          ++L +  +  Q +  + E 
Sbjct: 516  QQDQELAGLKQQAKE----------KQAQLA----------QTLQQQEQASQGLRHQVEQ 555

Query: 288  LRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQI----G 343
            L  S  + E Q K +  +    R +H   +A + +      E S  E  AA  Q+     
Sbjct: 556  LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE----REASLRERDAALKQLEALEK 611

Query: 344  ELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHA 403
            E + K++ LQ + +V          +  Q+ R   E   +  +   CV     E HE+ A
Sbjct: 612  EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671

Query: 404  -------------------VRLCRARE--AEVLPGLREQAALVSKAIDVLVADANGFTAG 442
                                R+ + ++   E L  L+E   +   +++     A      
Sbjct: 672  QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE 731

Query: 443  LRLCLDNECADFR------LHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRK--AD 494
             + C+    A+ R        E  +  E     K + A L +L    Q      R+  A+
Sbjct: 732  QQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE 791

Query: 495  AVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRT 554
            A+      E +           + L KE+   ++   D Q    ++  ++    +E   T
Sbjct: 792  AMAAQHTAESE----------CEQLVKEVAAWRERYEDSQ----QEEAQYGAMFQEQLMT 837

Query: 555  GDLDSKPDPSRSFRPYRAEDNDSYASEIKELQL-----VLAEAHDSL-RGLQEQLSQERQ 608
              L  + + +R      A++  +      ELQ+      LAE H +L R LQ+   +E +
Sbjct: 838  --LKEECEKARQ-ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVR 894

Query: 609  LRK--EEADNFNQKMVQLKEDQQR--ALLRREFELQSLSLQRRLEQKFWSQEKN---MLV 661
             +K  ++     +KM    ++  R   L+R+  E Q  + +  +++   + ++    +  
Sbjct: 895  AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEE 954

Query: 662  QESQQFKHNFLLLFMKLRWF------LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEE 715
            Q+ +QF      L    R        L+R R   ++ S+G    E    +     + +E 
Sbjct: 955  QQGRQFCSTQAALQAMEREAEQMGNELERLR-AALMESQGQQQEERGQQEREVARLTQER 1013

Query: 716  INAQH--SDNKACTG--DSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQ-QQ 770
              AQ   +  KA     +   QN  NE     A ++  L         + + L +L+  +
Sbjct: 1014 GRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE 1073

Query: 771  FAKAKATWETERA--ELKGHTSQMELKTGKGAG---------ERAGPDWKAALQREREEQ 819
             A+ K   E  +   +LK   ++ E +   G+G         E  GP  + AL+ E  + 
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE-ALRAEVSKL 1132

Query: 820  QHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKA 879
            +    +       L R L+ +ER    E+   +E LQG+ ++  Q++   Q+ L+  Q+ 
Sbjct: 1133 EQQCQKQQEQADSLERSLE-AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191

Query: 880  ADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKS-VSSMSEFESLLD 938
               +  K  +  K ++ WK             ++V  G    +R  S +SS+ E  S+L+
Sbjct: 1192 LAAFRTKVQDHSKAEDEWK-------------AQVARGRQEAERKNSLISSLEEEVSILN 1238



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 69/294 (23%), Positives = 133/294 (45%), Gaps = 30/294 (10%)

Query: 599 LQEQLSQERQLRKEEAD-NFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEK 657
           LQ    Q R+L+K+ AD   N+  ++L+  + R LL  E + Q   +Q+R+++     EK
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLL-TEKDAQIAMMQQRIDRLALLNEK 267

Query: 658 N----MLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKE----LYL 709
                +  +E ++ +     L M+L   LK+ +  K   S+ D   ++N + E    L  
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMD--RKINQLSEENGDLSF 325

Query: 710 LMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQ 769
            + E   + Q   +              E+++  A ++   KEL   L+D++    E + 
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE---KELSAALQDKK--CLEEKN 380

Query: 770 QFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSA 829
           +  + K       ++L+ H SQ++    +  GE  G      LQ E  +Q+     + + 
Sbjct: 381 EILQGKL------SQLEEHLSQLQDNPPQEKGEVLGD----VLQLETLKQEAATLAANNT 430

Query: 830 VMELTRQLQISERNWSQEKLQLVER--LQGEKQQVEQQVKELQNRLSQLQKAAD 881
            ++   ++  +ER   + KL L ER   + EKQQ+   + +LQ+ +S L +A +
Sbjct: 431 QLQARVEMLETERGQQEAKL-LAERGHFEEEKQQLSSLITDLQSSISNLSQAKE 483



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 45/202 (22%), Positives = 87/202 (43%), Gaps = 37/202 (18%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERR---SLRAAQTGQVD-GEL 57
            +E  +V+  E   Q++EL ++L  + +  ++ Q +L+  + +   S + AQ  Q    EL
Sbjct: 1537 VEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNEL 1596

Query: 58   IRGLEQDVKVSKDISMRLHK-------------ELEVVEKKRARLEEENEELR------- 97
               L Q  + ++   +++ K             EL+   +   +L++EN+ELR       
Sbjct: 1597 QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLG 1656

Query: 98   ----QRLIETELAKQVLQ------TELERPREHSLKKRGTRSLGKADKKT-LVQEDSADL 146
                Q  ++T+ A+Q  +        LE    H+   +  R LGK    T  ++      
Sbjct: 1657 HELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA--DQQLRDLGKFQVATDALKSREPQA 1714

Query: 147  KCQLHFAKEESALMCKKLTKLA 168
            K QL  + +   L C++ T L+
Sbjct: 1715 KPQLDLSIDSLDLSCEEGTPLS 1736


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1515

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1574

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1692

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1744

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1805 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1910

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1911 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1963

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1964 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2135

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2193

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2194 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2307

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 912  SEVE 915
             E E
Sbjct: 2368 LEAE 2371



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1772

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1832 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1887

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1888 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1937

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 1993

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2051

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2102

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2163 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2212

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2271

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2330

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2331 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2378

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2439 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQ 2578



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1646

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1647 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1702

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1763 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1813

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2045

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2163

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2164 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2218

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2219 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2264

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2265 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2321 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2423

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2475

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2476 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1948

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2186

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2238

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2419 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2578

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2579 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2628



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1849 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2028 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2133

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2175

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2234

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2292

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2293 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2338

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2456 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2506

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2507 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2602



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1707

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1464 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1519

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1578

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1638

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1696

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1748

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1749 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1808

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1809 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1914

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1915 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1967

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1968 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2139

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2197

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2198 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2311

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2312 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2371

Query: 912  SEVE 915
             E E
Sbjct: 2372 LEAE 2375



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1776

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1836 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1891

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1892 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1941

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 1997

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2055

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2106

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2167 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2216

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2275

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2276 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2334

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2335 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2382

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2442

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2443 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQ 2582



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1650

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1651 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1706

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1767 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1817

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1818 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1877

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1878 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1937

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2049

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2109

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2110 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2167

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2168 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2222

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2223 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2268

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2269 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2325 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2427

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2479

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2480 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1952

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2190

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2242

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2422

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2423 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2474

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2582

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2583 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2632



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1853 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1911

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2031

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2032 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2137

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2179

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2180 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2238

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2296

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2297 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2342

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2400 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2459

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2460 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2510

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2511 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2606



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1416

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1417 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1711

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1515

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1574

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1692

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1744

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1805 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1910

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1911 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1963

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1964 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2135

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2193

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2194 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2307

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 912  SEVE 915
             E E
Sbjct: 2368 LEAE 2371



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1772

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1832 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1887

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1888 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1937

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 1993

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2051

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2102

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2163 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2212

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2271

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2330

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2331 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2378

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2439 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQ 2578



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1646

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1647 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1702

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1763 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1813

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2045

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2163

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2164 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2218

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2219 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2264

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2265 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2321 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2423

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2475

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2476 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1948

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2186

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2238

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2419 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2578

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2579 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2628



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1849 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2028 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2133

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2175

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2234

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2292

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2293 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2338

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2456 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2506

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2507 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2602



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1707

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1428 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1483

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1542

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1660

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1712

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1773 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1878

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1879 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1931

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1932 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2103

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2161

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2162 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2216

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2275

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2276 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2335

Query: 912  SEVE 915
             E E
Sbjct: 2336 LEAE 2339



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1740

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1800 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1855

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1856 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1905

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 1961

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2019

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2070

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2131 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2180

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2239

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2240 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2298

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2299 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2346

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2406

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2407 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQ 2546



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1614

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1615 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1670

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1730

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1731 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1781

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1782 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1841

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1842 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1901

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2013

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2073

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2074 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2131

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2132 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2186

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2187 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2232

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2233 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2289 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2391

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2443

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2444 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1916

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2154

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2206

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2386

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2387 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2438

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2546

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2547 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2596



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1817 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1875

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 1995

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 1996 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2101

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2143

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2144 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2202

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2260

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2261 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2306

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2364 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2423

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2424 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2474

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2475 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2570



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1380

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1381 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1675

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1724


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1652

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1711

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1771

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1829

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1881

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1882 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1941

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1942 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 2047

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 2048 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 2100

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 2101 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2272

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2330

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2331 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2444

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2504

Query: 912  SEVE 915
             E E
Sbjct: 2505 LEAE 2508



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1909

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1969 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 2024

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 2025 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 2074

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 2130

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2188

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2239

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2300 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2349

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2408

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2409 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2467

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2468 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2515

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2575

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2576 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQ 2715



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1783

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1784 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1839

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1899

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1900 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1950

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1951 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 2010

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 2011 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2182

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2242

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2243 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2300

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2301 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2355

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2356 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2401

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2402 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2458 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2560

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2612

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2613 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 2085

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2323

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2375

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2555

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2556 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2607

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2715

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2716 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2765



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1986 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 2044

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2164

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2165 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2270

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2312

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2313 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2371

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2429

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2430 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2475

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2533 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2592

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2593 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2643

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2644 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2739



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1549

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1550 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1844

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1438 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1493

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1552

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1612

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1670

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1722

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1723 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1782

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1783 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1888

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1889 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1941

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1942 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2113

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2171

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2172 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2285

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2286 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2345

Query: 912  SEVE 915
             E E
Sbjct: 2346 LEAE 2349



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1750

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1810 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1865

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1866 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1915

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 1971

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2029

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2080

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2141 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2190

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2249

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2250 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2308

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2309 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2356

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2416

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2417 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQ 2556



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1624

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1625 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1680

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1741 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1791

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1792 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1851

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1852 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1911

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1971

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2023

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2083

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2084 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2141

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2142 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2196

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2197 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2242

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2243 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2299 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2401

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2453

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2454 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1926

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2164

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2165 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2216

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2276

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2277 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2337 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2396

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2397 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2448

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2556

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2557 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2606



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1827 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1885

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2005

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2006 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2060

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2111

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2153

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2154 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2212

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2270

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2271 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2316

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2374 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2433

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2434 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2484

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2485 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2580



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1390

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1391 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1685

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1446 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1501

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1560

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1620

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1678

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1730

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1731 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1790

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1791 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1896

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1897 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1949

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1950 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2121

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2179

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2180 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2234

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2293

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2294 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2353

Query: 912  SEVE 915
             E E
Sbjct: 2354 LEAE 2357



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1758

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1818 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1873

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1874 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1923

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 1979

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2037

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2038 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2088

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2149 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2198

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2257

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2258 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2316

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2317 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2364

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2424

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2425 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQ 2564



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1632

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1633 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1688

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1689 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1748

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1749 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1799

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1800 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1859

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1860 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1919

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1979

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2031

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2091

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2092 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2149

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2150 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2204

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2205 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2250

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2251 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2307 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2409

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2461

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2462 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1934

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2172

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2173 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2224

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2284

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2285 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2344

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2345 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2404

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2405 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2456

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2517 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2564

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2565 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2614



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1835 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1893

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2013

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2014 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2068

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2119

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2161

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2162 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2220

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2278

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2279 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2324

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2382 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2441

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2442 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2492

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2493 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2588



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1398

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1399 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1693

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1694 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1742


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 210/964 (21%), Positives = 377/964 (39%), Gaps = 115/964 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK----- 69
            QL+   +Q   A    + L+ R  +AE +  +A    Q + E +R   QD    K     
Sbjct: 1487 QLEATERQRGGAEGELQALRARAEEAEAQKRQA----QEEAERLRRQVQDESQRKRQAEV 1542

Query: 70   DISMRLHKELEVV-EKKRA-------RLEEENEELRQRLIETELAKQVLQTELERPREHS 121
            +++ R+  E E   EK+RA       RL+ E  E R R  E E A+QV Q  LE  +  +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSA 1601

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
              +  ++    A+K   ++    +    +   +EE+    ++  +  +  +  + EL ++
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1661

Query: 182  RSLYGD-LDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            +    + L   L AEE+A      + E +   +  E EA    +   E  V  R L AE 
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQREL-AEQ 1719

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELR-------RHLQFVEEEAELLRRSSA 293
            +  K      G  + RLA          + L  LR       +  Q +EEE   L+R +A
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAE--------QELIRLRAETEQGEQQRQLLEEELARLQREAA 1771

Query: 294  ELEDQNKLLLNELAKFRSEHEL---DVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
                + + L  ELAK R+E E+     A +E+     SE S++ L A   +  EL+ +  
Sbjct: 1772 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1831

Query: 351  KLQYENRVLLSNLQR-CDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRA 409
            +L    R L    +R   LA   + R   E +    +    +        E+      + 
Sbjct: 1832 RL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887

Query: 410  REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDT 469
             E E L  L E  A   + ++   A             D E    +L +A D SE  R  
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKA---------DIEERLAQLRKASD-SELERQK 1937

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDL 529
             L+   L +   +++E+ A   KA      + K + E       LG    + E  L    
Sbjct: 1938 GLVEDTLRQRRQVEEEILAL--KASFEKAAAGKAELEL-----ELGRIRSNAEDTLRSKE 1990

Query: 530  GSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVL 589
             ++ +    R L   E R     R  + + +   S +     A    +   E++ L+  +
Sbjct: 1991 QAELEAARQRQLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045

Query: 590  AEA--------HDSLRGLQ--EQLSQERQLRKEEADNF-----NQKMVQLKEDQQRAL-- 632
             EA         +S R LQ  ++ +Q+R   +E+A  F      Q++ Q  + +Q  L  
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105

Query: 633  LRREFELQSLSLQR----RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQG 688
            LR E E    + +     R++ +  + +    V+E+++ K +      + +   +     
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS---AEEQAQARAQAQAAA 2162

Query: 689  KVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            + L  E +      +  E   L +++  +A+   +K     +  Q    E  + L  +++
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE--QELTTLRL 2220

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETER-----AELKGHTSQME----LKTGKG 799
             L+E      D ++ L + + Q  KA+AT    +      EL     QME    LK    
Sbjct: 2221 QLEE-----TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2275

Query: 800  AGERA-----GPDWKAALQREREEQQHLLAESYS---AVMELTRQLQISERNWSQEKLQL 851
            A  RA       + +  LQ E E+ + +  E+     A  E  R  Q++E + +Q++  L
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR-AL 2334

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E++  EK Q  Q+   L+     LQ+  +    +   L++      +  +E+    +  
Sbjct: 2335 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2394

Query: 912  SEVE 915
             E E
Sbjct: 2395 LEAE 2398



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 206/922 (22%), Positives = 358/922 (38%), Gaps = 115/922 (12%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQ-VDGELIRGLEQDVKVSKDISM 73
            +L  LR + +Q  +  ++L+  L + +R +  A Q  Q ++ EL + +  +++V      
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEMEVLLASKA 1799

Query: 74   RLHKELEVV-EKKRARLEEENEELRQRLIETELAKQVLQTELERPR----EHSLKKRGTR 128
            R  +E     EK + RLE E    R+ L E     + L  E +R R    E + ++R   
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                A+K   + E +  LK +   A +E     ++L +LA++    +  L +  + +   
Sbjct: 1859 ERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1914

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
              A   E LA    + ++EL+    LVE+   L  RR VE E+    L+A  +       
Sbjct: 1915 -KADIEERLAQLRKASDSELERQKGLVED--TLRQRRQVEEEI--LALKASFEK-----A 1964

Query: 249  GCGGPEARL--------AFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              G  E  L        A   L   E  E  A  +R L   EE     RR  AE   Q  
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER----RRREAEERVQKS 2020

Query: 301  LLLNELAKFRSEHELD----VALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYEN 356
            L   E A  + +  L+    +    +    L E +++E +A +LQ+ + + + K+LQ E 
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ-KRLQAEE 2078

Query: 357  RVLLSNLQRCD------LASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR 410
            +     +Q+ +      L   QS    L  +AEA   A           E+   R+   R
Sbjct: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA---------AEEAEEARVQAER 2129

Query: 411  EAEVLPGLREQAALVSKAIDVLV---ADANGFTAGLRLCLDNECAD--------FRLHEA 459
            EA       E+A  + ++ +      A A      LR   + E A          R  +A
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189

Query: 460  PDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGL 519
             D +E  +  K     L + + ++QEL     +          E+ +   +L     Q L
Sbjct: 2190 AD-AEMEKHKKFAEQTLRQKAQVEQELTTLRLQL---------EETDHQKNLLDEELQRL 2239

Query: 520  SKEILLAKDLGSDFQPPDF------RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
              E   A    S  +   F       +L + + RI    R   L  K D ++ F    AE
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAE 2298

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKEDQQR 630
                 A E   L +   EA    +  +E L+Q+R L ++   E     Q+  +LK + + 
Sbjct: 2299 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE- 2357

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKV 690
             LL+++ EL     +R  E K   Q    L +E+Q F+              +R RQ ++
Sbjct: 2358 -LLQQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEA---------ERQRQLEM 2405

Query: 691  LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL 750
                    L V  M       EE+    +    +       T+    E +  +  +++  
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2465

Query: 751  KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH---TSQME--LKTGKGAGERAG 805
            ++        R  + EL+++  K K   E +  +LK     T Q E  L+  +   +   
Sbjct: 2466 QQSDHDAERLREAIAELERE--KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523

Query: 806  PDWKAALQREREEQQH------LLAESYSAVMELTRQLQISERNWSQEKLQLV---ERLQ 856
             +  + LQRER  +Q       L  +  +   +L  + Q  ++   QE+ +LV   E  +
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583

Query: 857  GEKQQVEQQVKELQNRLSQLQK 878
              + + E+ V+  Q  L QL++
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQ 2605



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/1011 (20%), Positives = 415/1011 (41%), Gaps = 153/1011 (15%)

Query: 18   ELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQ-DVKVSKDISMRL 75
            E   QL+++ +   +   +LR+ AERR+ + A+  +   E  R LE+  +K ++ + +RL
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1673

Query: 76   HKELEVVEKK---RARLEEENEELRQRLIETELAKQ--VLQTELERPREHSLKKRGTRSL 130
              E EV ++K   +A  E++ EE  +       A++  V Q EL    E  L+K+   + 
Sbjct: 1674 QAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA---EQELEKQRQLAE 1729

Query: 131  GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKE-------NDSMKEELLKYRS 183
            G A ++   +++   L+ +    +++  L+ ++L +L +E          ++ EL K R+
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
               +++  L+++  A+   SR T  K   +L E EA     R  EL  E   LRA  ++ 
Sbjct: 1790 ---EMEVLLASKARAEE-ESRSTSEKSKQRL-EAEAG----RFRELAEEAARLRALAEEA 1840

Query: 244  K--------DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAEL 295
            K        D        E  LA      GE      E    L+  E E E LRR + + 
Sbjct: 1841 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1900

Query: 296  EDQNKLLLNELAKFRSEHELDVA-LSEDSCSVLSEPS-------------QEELAAAKLQ 341
              Q + L  + A+ +++ E  +A L + S S L                 +EE+ A K  
Sbjct: 1901 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1960

Query: 342  IGELSGKVKKLQYENRVLLSNLQ-------RCDLASCQSTRPMLETDAEAGDSAQCVPAP 394
              + +    +L+ E   + SN +       + +L + +  +   E +    ++ + V   
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2020

Query: 395  LGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF 454
            L    E+   R     E E L    E+A  + +  +          +  +L L  E A  
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ--------ESARQLQLAQEAAQK 2072

Query: 455  RLH---EAPDNSEGPRDTKLIHAILVRLSVLQQ---ELNAFTRKADAVLGCSVKEQQESF 508
            RL    +A   +   ++ +L   +    SVL Q   E  A  R A+      V+ ++E+ 
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2132

Query: 509  SSLPPLG------------SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556
             S   +             +Q  ++    A+ L  + +    R     +  +R+      
Sbjct: 2133 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA-- 2190

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
             D++ +  + F             E+  L+L L E       L E+L    Q  K EA  
Sbjct: 2191 -DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL----QRLKAEATE 2245

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
              ++  Q++E+    L     +++ LS   +L+ +  ++ + +++++    +        
Sbjct: 2246 AARQRSQVEEE----LFSVRVQMEELS---KLKARIEAENRALILRDKDNTQR------- 2291

Query: 677  KLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-MEEEEINAQHSDNKACTGDSWTQNT 735
                FL+   +     +E    L V + +   L  + EE++  Q +  +    +      
Sbjct: 2292 ----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKA--------TWETERA---E 784
                +K  A++    KEL    +++ R L E ++Q A+  A        T E ER    E
Sbjct: 2348 EATRLKAEAELLQQQKELA---QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404

Query: 785  LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNW 844
            +     +++L+  + +  +A  +  A   R++ E+          + E   + +++    
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE----------IGEKLHRTELA---- 2450

Query: 845  SQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
            +QEK+ LV+ L+ ++QQ +   + L+  +++L+        +  E  +Q+    + +SE+
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELE--------REKEKLQQEAKLLQLKSEE 2502

Query: 905  IHDKEAVSEVELGGNGLKRTKSV--SSMSEFESLLDCSPYLAGGDARGKKL 953
            +   + V + +L    L+ T+++  S +SE +SLL    ++    A+ ++L
Sbjct: 2503 M---QTVQQEQL----LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 168/776 (21%), Positives = 297/776 (38%), Gaps = 85/776 (10%)

Query: 9    MEEDVYQLQ-----ELRQQLDQASKTCRILQYRLRKAERRSLRA----AQTGQVDGEL-- 57
            +EE + QL+     EL +Q      T R  Q R  + E  +L+A    A  G+ + EL  
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLR--QRRQVEEEILALKASFEKAAAGKAELELEL 1975

Query: 58   --IRGLEQDVKVSKD-ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
              IR   +D   SK+   +   ++ ++  ++  R  E  E +++ L   E A +  +  L
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035

Query: 115  ERPREHSLKKRGTRSLG-KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            E       K    R L  +A++++  Q   A    Q     EE A       K  +   +
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095

Query: 174  MKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVEN 233
            +++E      L G+ ++A  A E A+    +        +   EEA  L +   E     
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF----------VEE 283
               +A  + ++          A+   +AL   +  +  AE+ +H +F          VE+
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2213

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
            E   LR    E + Q  LL  EL + ++E       + ++    S+  +EEL + ++Q+ 
Sbjct: 2214 ELTTLRLQLEETDHQKNLLDEELQRLKAE-------ATEAARQRSQV-EEELFSVRVQME 2265

Query: 344  ELSGKVKKLQYENRVLL----SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPA--PLGE 397
            ELS    +++ ENR L+     N QR      +  + + E  A    +AQ       L E
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2325

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
               +    L      E +  ++E   L ++A  +            RL  D E    +L 
Sbjct: 2326 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385

Query: 458  EAPDNS----EGPRDTKL-IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSL- 511
            E         E  R  +L + A   RL +   E++    +A+       K+ +E    L 
Sbjct: 2386 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2445

Query: 512  -PPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDS-KPDPSRSFRP 569
               L +Q   +++ L + L    Q  D         R+REA    + +  K         
Sbjct: 2446 RTELATQ---EKVTLVQTLEIQRQQSDHD-----AERLREAIAELEREKEKLQQEAKLLQ 2497

Query: 570  YRAED-----NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
             ++E+      +    E + LQ       DSL   +  + QE+   ++   +   K  QL
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2557

Query: 625  KEDQQRALLRREFELQSL--SLQRRLEQKFWSQEKNMLVQES-QQFKHNFLLLFMKLRWF 681
            +E+QQR   + E E Q L  S++    ++  ++E     QE  QQ +             
Sbjct: 2558 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ------------ 2605

Query: 682  LKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             +R +Q ++L  E     E     +L LL E+      HS+    +  + T+  PN
Sbjct: 2606 -QRRQQEELLAEENQRLRE-----QLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2655



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 189/885 (21%), Positives = 346/885 (39%), Gaps = 123/885 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E +  + +EL ++  +        + + + AE  + R  A+  +V  E +  + +  ++
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRL----------IETELAKQVLQTELERP 117
              +  + L KE E   ++  RL E+    R+RL          IE  LA+    ++ E  
Sbjct: 1876 KTEAEIAL-KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1934

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDS--------ADLKCQLHFAKE--ESALMCKKLTKL 167
            R+  L +   R   + +++ L  + S        A+L+ +L   +   E  L  K+  +L
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994

Query: 168  --AKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRR 225
              A++     EE  + R     +  +L+AEE A        E    LK   EEA  L  R
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2054

Query: 226  IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG-ECGESLAELRRHLQFVEEE 284
              +       L  E    +         E   AF+      E  ++L + +  L  +  E
Sbjct: 2055 AEQESARQLQLAQEAAQKR-----LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2109

Query: 285  AELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGE 344
            AE  RR++ E E+       E A+ R + E    L +         S EE A A+ Q   
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ---------SAEEQAQARAQAQA 2160

Query: 345  LSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAV 404
             + K++K   +     +  ++  L   Q+       DAE             E H+  A 
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQA------ADAEM------------EKHKKFAE 2202

Query: 405  RLCR--AREAEVLPGLR-------EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            +  R  A+  + L  LR        Q  L+ + +  L A+A    A  R  ++ E    R
Sbjct: 2203 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEELFSVR 2261

Query: 456  LHEAPDNSEGPRDTKLIHAILVR-----LSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
            +     +    R      A+++R        LQ+E     + A+     SV  Q+   + 
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA--AR 2319

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPY 570
            L  L  + L+++  LA+ +           L E    ++EA R   L ++ +  +  +  
Sbjct: 2320 LRQLAEEDLAQQRALAEKM-----------LKEKMQAVQEATR---LKAEAELLQQQKEL 2365

Query: 571  RAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE---EADNFNQKMVQLKED 627
              E       + +++   LAE     +G Q  L  ERQ + E   EA+    ++ ++   
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422

Query: 628  QQRALL-RREFELQSLSLQRRLEQ-KFWSQEKNMLVQ----ESQQFKHNFLLLFMKL--- 678
            Q RA    + F  Q+  +  +L + +  +QEK  LVQ    + QQ  H+   L   +   
Sbjct: 2423 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2482

Query: 679  -RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPN 737
             R   K  ++ K+L  + +   E+ ++++  LL E + +       K    DS  Q    
Sbjct: 2483 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQSFLSEK----DSLLQRE-- 2533

Query: 738  EYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTG 797
               + +   K  L++   L +DE     +L+++  + +   E ER  L     +   +  
Sbjct: 2534 ---RFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587

Query: 798  KG-AGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISE 841
            +   G R   +    L+++R +Q+ LLAE    + E   QLQ+ E
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE---QLQLLE 2629



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 93/409 (22%), Positives = 178/409 (43%), Gaps = 65/409 (15%)

Query: 545  EPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE-----------AH 593
            + R  E  R  ++++  +  R      A+       E KELQ  + E           A 
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1439

Query: 594  DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFW 653
               R +QE+L Q RQ  + E     Q   +  E  +R+ LR E E++ + LQ    ++  
Sbjct: 1440 QQKRSIQEELQQLRQSSEAEI----QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 654  SQEKNML------VQESQQFKHNFLLLFMKLRWFLK----RWRQGKV-----LPSEGDDF 698
               +  L       +E++  K        +LR  ++    R RQ +V     + +E +  
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555

Query: 699  LE----VNSMKELYLLMEEEEINAQHSDNKAC------------TGDSWTQNTPNEYIKT 742
             E    + +++EL L  EE E   + ++ +              + ++  Q+    + + 
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615

Query: 743  LADMKVTLKE---LCWLLRDE--RRGLTELQQQFAKAKATWETERAELKGHTS-QMELKT 796
             A ++ +L+E       LR+E  RR   + + + A+ +A  E ER +LK + + ++ L+ 
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675

Query: 797  GKGAGERAGPDWKAALQREREE---------QQHLLAESYSAVMELTRQLQISERNWSQE 847
             + A +++    +A  Q+E  E         ++  + +   A  EL +Q Q++E   +Q+
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT-AQQ 1734

Query: 848  KL---QLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            +L   Q + RL+ E +Q EQQ + L+  L++LQ+ A     K  ELE +
Sbjct: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 204/976 (20%), Positives = 391/976 (40%), Gaps = 127/976 (13%)

Query: 19   LRQQLDQASKTCRILQYRLRKAE-RRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHK 77
            L+QQ DQ  +  + L+ RL+K    R   A QT  + GE +  L ++ ++ +     L +
Sbjct: 419  LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGE-VDSLSKERELLQKAREELRQ 477

Query: 78   ELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL-------ERPREHSLKKRGTRSL 130
            +LEV+E++  RL   N EL+ +    +  K+  Q EL       ER +E  +     +S 
Sbjct: 478  QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE 537

Query: 131  GKADKKTLVQE-DSADLKCQLHFAKEESALMC------KKLTKLAKENDSMKEELLKYRS 183
              ++  TL +  +S+ L+ +L   +E++ +        + + +L+   +++K E+   R+
Sbjct: 538  SLSELITLREALESSHLEGEL-LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRA 596

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
                  +A+    L +A    +  L   L  +EEE   +  R+   E     L+ ++ + 
Sbjct: 597  ------AAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEA 650

Query: 244  KDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLL 303
            +            L        E G   AEL+  L+ ++EE E +++  +E   Q +   
Sbjct: 651  EKRREALWEKNTHLEAQLQKAEEAG---AELQADLRDIQEEKEEIQKKLSESRHQQEAAT 707

Query: 304  NELAKF-----RSEHELDVALSEDSCSVLSEPSQE-ELAAAKLQIGELSGKVKKLQYENR 357
             +L +      R E  L  A+ E    V  + + E  L A +    +L+ +++ L     
Sbjct: 708  TQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKE 767

Query: 358  VLLSNLQRCDLAS--CQSTRPMLETDAEAGDSA--------QCVPAPL------GETHES 401
            +L S+L      +   + T+  LE   +    A        +C+   L       E    
Sbjct: 768  LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827

Query: 402  HAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPD 461
             A R     E E    L +Q A   K ++            LR   + E   +   E   
Sbjct: 828  AAARQLAQAEQEGKTALEQQKAAHEKEVN-----------QLREKWEKE-RSWHQQELAK 875

Query: 462  NSEGPRDTKLIHAILVRLSVLQQELNAF--------TRKADAVLGCSVKEQQESFSSLPP 513
              E     K+   + +RL   Q E+ A         T+   A+    ++ ++E  S L  
Sbjct: 876  ALESLEREKM--ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLET 933

Query: 514  LGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSK-PDPSRSFRPYRA 572
            L        +   K+L    Q  +         +++E   TG L ++  +  R  +    
Sbjct: 934  L--------LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985

Query: 573  EDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQ--LKEDQQR 630
            +  D  A+  +E   +L +  D  + +++  SQ   + ++++    ++ VQ  L+E Q+ 
Sbjct: 986  QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQ--LVAQDDSQRLVEQEVQEKLRETQEY 1043

Query: 631  ALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWR-QGK 689
              +++E E +  SL   L +K   +++ +++QE+   +   L     LR  ++  + + K
Sbjct: 1044 NRIQKELEREKASLTLSLMEK---EQRLLVLQEADSIRQQEL---SALRQDMQEAQGEQK 1097

Query: 690  VLPSEGDDFLEVNSMKELYLLMEE----EEINAQHSDNKACTGDSWTQNTPNEYIKTLAD 745
             L ++ +   +    KE   L +E    EE+ A H   +      W Q      ++    
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ--LR 1155

Query: 746  MKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAG 805
            ++ T  +L  L  +++ G  + Q Q   A      ++A      S+ EL    G G+ A 
Sbjct: 1156 LRSTESQLEALAAEQQPG-NQAQAQAQLASLYSALQQALGSVCESRPEL---SGGGDSAP 1211

Query: 806  PDWKAALQREREEQQHL-----LAESYSAVMELTRQLQISERNWSQEKL---------QL 851
              W   L+ ++   + L     L  + SA    +   ++ +  W  ++          +L
Sbjct: 1212 SVW--GLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKL 1269

Query: 852  VERL---QGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKET-------- 900
             ERL   + EK QV  ++++LQ +LSQ Q+    W  K + LE +     ET        
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL 1329

Query: 901  RSEKIHDKEAVSEVEL 916
            R  ++   EA  E EL
Sbjct: 1330 RRAELQRMEAQGEREL 1345



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 211/975 (21%), Positives = 386/975 (39%), Gaps = 140/975 (14%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL 61
            LE+  + +++   ++   ++Q+ +  K   +L++     + R  +      V  E IR L
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT----VQREQIREL 1513

Query: 62   EQDVKVSKDISMRLHKELEVVEKKRARLEEEN---EELRQRLIETEL------------- 105
            E+D +  +++   L  +L  +EKK   +E +    ++L+++L+  E              
Sbjct: 1514 EKDRETQRNV---LEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570

Query: 106  AKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLT 165
             +Q L  ELE  RE         +L   ++   +Q  S+    Q+H  +  S ++ ++L 
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSS----QIHDLESHSTVLARELQ 1626

Query: 166  KLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVE--EEANLLS 223
            +  +E  S +E++ + +            E L      R+ EL +  + ++  E+     
Sbjct: 1627 ERDQEVKSQREQIEELQR---------QKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677

Query: 224  RRIVELEVEN---------RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAEL 274
             +I+E ++E          R L  +   M++      GP       A  G     SL  +
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS-----KAQRG-----SLEHM 1727

Query: 275  RRHLQFVEEEAELLRR---SSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPS 331
            +  L+  E+E E  +       EL+DQ +  L  L +   E  L ++  E    VL +  
Sbjct: 1728 KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787

Query: 332  QE-----ELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD 386
            QE     EL    LQ  +L    + L   ++ L +  Q    A  Q  R   + DA  G 
Sbjct: 1788 QEAREQGELKEQSLQ-SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGA 1846

Query: 387  SAQCVPAPLGETH---ESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGL 443
              Q     L E H   + H  +  R  E   + G R QA  + + +  L A++      L
Sbjct: 1847 LEQA-HMTLKERHGELQDHKEQARRLEEELAVEGRRVQA--LEEVLGDLRAESREQEKAL 1903

Query: 444  RLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKE 503
             L L  +CA+ +  E    +   +D+ L    +  L    QEL A   ++      S + 
Sbjct: 1904 -LALQQQCAE-QAQEHEVETRALQDSWLQAQAV--LKERDQELEALRAESQ-----SSRH 1954

Query: 504  QQESFSSLPPLGSQGLSKE--ILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKP 561
            Q+E+  +      + L K    L  K+     Q    R L      ++ +       S+ 
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014

Query: 562  -DPSRSFRPYRAEDND-SYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQ 619
             + +   +    +D D  Y  ++++LQ  LA+  + LR  QE   +E+ L K  A    +
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE---REQLLEKSLAQRVQE 2071

Query: 620  KMVQLKEDQQRALLRREFELQSLSLQ-RRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKL 678
             M+Q  E Q     R E E++ L    R L+     +E+ +L     Q ++N   L    
Sbjct: 2072 NMIQ--EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEAL---- 2125

Query: 679  RWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNE 738
                      K  P E +  L+++S+ E  L  E E + A     +A     W +    +
Sbjct: 2126 ------PHSHKTSPME-EQSLKLDSL-EPRLQRELERLQAALRQTEA-REIEWREKA-QD 2175

Query: 739  YIKTLADMKV---TLKELCWLL------RDERRGLTELQQQFAKAKATWETERAELKGHT 789
               +LA  K    +L+E+   L      RD  +    LQ +    +   E ER    G T
Sbjct: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQ--QRLQDELELTRRALEKERLHSPGAT 2233

Query: 790  SQMEL----KTGKGAGERAGPDWKAA-----LQREREEQQHLLAESYSAVMELTRQLQIS 840
            S  EL    + G   GE +G + + +      Q  R+  +HL         +   +L+I 
Sbjct: 2234 STAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHL--------QQAVARLEID 2285

Query: 841  ERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKET 900
                 +  +QL   L    +QVE++ ++L+    +  +AA    L+ S+      + ++ 
Sbjct: 2286 RSRLQRHNVQLRSTL----EQVERERRKLKR---EAMRAAQAGSLEISKATASSPTQQDG 2338

Query: 901  RSEKIHDKEAVSEVE 915
            R +K  D + V+E++
Sbjct: 2339 RGQKNSDAKCVAELQ 2353



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 189/858 (22%), Positives = 329/858 (38%), Gaps = 113/858 (13%)

Query: 74   RLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKA 133
            +LH++L   ++ R  L ++ ++L +RL +TE  K  + TEL+  +    + +  +S  + 
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306

Query: 134  DKKTL------VQEDSADLKCQLHFAKEE--SALMCKKLTKLAKENDSMKEELLKYRSLY 185
             + +L      + E  A L+ +L  A+ +   A   ++L + AKEN + + E L+     
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ----- 1361

Query: 186  GDLDSALSAEELADAPHSRETELKV---HLKLVEEEANLLSRRIVELEVENRGLRAEMDD 242
                + + A   A A    E +L+     LKL  EE        VE E E      E  +
Sbjct: 1362 ---AAVVEARAQASAAGILEEDLRTARSALKLKNEE--------VESERERAQALQEQGE 1410

Query: 243  MKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQN--- 299
            +K                   G    E+LA L + L   EEE E LR    ELE Q    
Sbjct: 1411 LK----------------VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454

Query: 300  ----KLLLNELAKFRSEHEL---DVALSEDSCSVLS------EPSQEELAAAKLQIGELS 346
                +LL  +L K   E +L    +   E   SVL       +  +++L   + QI EL 
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514

Query: 347  GKVKKLQYENRVL---LSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHA 403
               K  + +  VL   L  L++ D    +S R  ++   +   + +C+   L E H    
Sbjct: 1515 ---KDRETQRNVLEHQLLELEKKD-QMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570

Query: 404  VRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHE---AP 460
               C+ +  + L G RE   +   A+  L  D    +  L+    ++  D   H    A 
Sbjct: 1571 ---CQQKLIKELEGQRETQRV---ALTHLTLDLEERSQELQ-AQSSQIHDLESHSTVLAR 1623

Query: 461  DNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCS---VKEQQESFSSLPPLGSQ 517
            +  E  ++ K     +  L   ++ L     + D  L      ++  ++  +    +  +
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683

Query: 518  GLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKP-----DPSRSFRPYRA 572
             L +  L  ++ G        R+L      ++E    G   SK      +  +     + 
Sbjct: 1684 DLEQIKLSLRERG--------RELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735

Query: 573  EDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRAL 632
            ++ +     I ELQ +  +    L+GL  ++ +   L  +      Q++V L++  Q A 
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR----EQEIVVLQQQLQEAR 1791

Query: 633  LRREFELQSL-----SLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQ 687
             + E + QSL       QR L Q+   QE   L QE QQ +     +  K         Q
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQR--DQELEALQQEQQQAQGQEERVKEKADALQGALEQ 1849

Query: 688  GKVLPSEGDDFLEVNSMKELYLLMEEEEI--NAQHSDNKACTGDSWTQNTPNEYIKTLAD 745
              +   E     E+   KE    +EEE      +    +   GD   ++   E  K L  
Sbjct: 1850 AHMTLKERHG--ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQE--KALLA 1905

Query: 746  MKVTLKELCWLLRDERRGLTE--LQQQFAKAKATWETERAELKGHTSQMELKTGKGAGER 803
            ++    E       E R L +  LQ Q    +   E E    +  +S+ + +  +   E 
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965

Query: 804  AGPDWKAALQREREEQQHLL--AESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQ 861
                   A    + ++QHLL  AE   ++   T  LQ S         QL E L+ ++ +
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGE 2025

Query: 862  VEQQVKELQNRLSQLQKA 879
            ++ Q    Q  + QLQ+A
Sbjct: 2026 IQDQDLRYQEDVQQLQQA 2043



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 197/953 (20%), Positives = 365/953 (38%), Gaps = 148/953 (15%)

Query: 16   LQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKVSKDISMR 74
            L +L Q L +  +T  +L+ +++K E R     A+  QV  EL     QD          
Sbjct: 1245 LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTEL-----QD---------- 1289

Query: 75   LHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKAD 134
            L ++L   ++++++ E +   L   L+E       LQ+ L R     ++ +G R L +A 
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349

Query: 135  KKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL-LKYRSLYGDLDSALS 193
            K+ L  +        L  A  E+         L ++  + +  L LK   +  + + A +
Sbjct: 1350 KENLTAQVE-----HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404

Query: 194  AEELADAPHSRETELKVHLKLV-------EEEANLLSRRIVELEVENRGLRAEMD----D 242
             +E  +   ++   L+ +L L+       EEE   L  +I ELE +    +A ++    D
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 243  MKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLL 302
            +K         + ++        +C   L  L   +Q  E++  + R    ELE   +  
Sbjct: 1465 LKKRNQEVDLQQEQIQELE----KCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520

Query: 303  LNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSN 362
             N L     EH+L   L  +    + E  + ++   K Q+  L     +L+ EN   +  
Sbjct: 1521 RNVL-----EHQL---LELEKKDQMIESQRGQVQDLKKQLVTLECLALELE-ENHHKMEC 1571

Query: 363  LQRC--DLASCQSTRPMLETDA--EAGDSAQCVPAPLGETH--ESHAVRLCRA---REAE 413
             Q+   +L   + T+ +  T    +  + +Q + A   + H  ESH+  L R    R+ E
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE 1631

Query: 414  VLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIH 473
            V    REQ   + +  + L  D         L L  E    R+    D  +  R TK++ 
Sbjct: 1632 V-KSQREQIEELQRQKEHLTQDLE--RRDQELMLQKE----RIQVLED--QRTRQTKILE 1682

Query: 474  AILVRLSV-LQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSD 532
              L ++ + L++     T +   +     + ++    S    GS    K IL  K+   +
Sbjct: 1683 EDLEQIKLSLRERGRELTTQRQLM---QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739

Query: 533  FQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEA 592
             Q     +L E + ++ +  +                           ++ E  L+L++ 
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQ-----------------------GLHRKVGETSLLLSQR 1776

Query: 593  HDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKF 652
               +  LQ+QL + R    E+ +   Q +    ++ QRAL +R+ EL++L  +++  Q  
Sbjct: 1777 EQEIVVLQQQLQEAR----EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832

Query: 653  WSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSE---------------GDD 697
              + K          +   + L  +         Q + L  E               GD 
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892

Query: 698  FLEVNSMKELYLLMEEE--EINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCW 755
              E    ++  L ++++  E   +H        DSW Q             +  LKE   
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ------------AQAVLKE--- 1937

Query: 756  LLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDW----KAA 811
              RD+     EL+   A+++++   E A  +     ++   GK      G +     +A 
Sbjct: 1938 --RDQ-----ELEALRAESQSSRHQEEAA-RARAEALQEALGKAHAALQGKEQHLLEQAE 1989

Query: 812  LQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQ------- 864
            L R  E     L  S  A    +RQL+ + R    E      R Q + QQ++Q       
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049

Query: 865  QVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHD-KEAVSEVEL 916
            +++  Q R   L+K+    V ++   EKQ N  +E   E+I    ++V E++L
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQ-NLGQEREEEEIRGLHQSVRELQL 2101



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 205/975 (21%), Positives = 382/975 (39%), Gaps = 121/975 (12%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL 61
            LEM+    + D+ +L+    +L  +  TC +   RL    + S     +G++DG     L
Sbjct: 192  LEMKSA-TDRDLMELKAEHVRLSGSLLTCCL---RLTVGAQ-SREPNGSGRMDGREPAQL 246

Query: 62   EQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHS 121
               +  ++++    H+  + + + +++ + E  EL+ R+  TEL+  + Q++ +      
Sbjct: 247  LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRV--TELSALLTQSQKQNEDYEK 304

Query: 122  LKKRGTRSLGKADKK-TLVQEDSADLKCQLHFAKEESALMCKKLTK-LAKENDSMKEELL 179
            + K    ++   +   T + E  A L       K     + K +T+ + +E D++ +   
Sbjct: 305  MIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSG 364

Query: 180  KYRSL-----------YGDLDSALS-AEELADAPHSRETELKVHLKLVEEEANLLSRRIV 227
               SL           Y D D AL+    +         +L+  L   +E  NLL ++  
Sbjct: 365  HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD 424

Query: 228  ELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLA----ELRRHLQFVEE 283
            + E E + LR  +  +        G    L        +  E L     ELR+ L+ +E+
Sbjct: 425  QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ 484

Query: 284  EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSE-----DSCSVLSEPSQEELA-- 336
            EA  LRR + EL+ Q      +  K   + EL +A+ E     +    L     E L+  
Sbjct: 485  EAWRLRRVNVELQLQGDSAQGQ--KEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542

Query: 337  ---AAKLQIGELSGKVKKLQYENRVLLSNLQRCD--LASCQSTRPMLETDAEAGDSAQCV 391
                  L+   L G++  L+ E   + + L R +  +A   S+   L+T+     +A   
Sbjct: 543  ITLREALESSHLEGEL--LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600

Query: 392  PAPLGETHESHAVRLCR-----AREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLC 446
             + L E      V L +       E + +    E A     A+ V +A+A        L 
Sbjct: 601  LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREA--LW 658

Query: 447  LDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQE 506
              N   + +L +A +             +   L  +Q+E     +K    L  S  +Q+ 
Sbjct: 659  EKNTHLEAQLQKAEEAGA---------ELQADLRDIQEEKEEIQKK----LSESRHQQEA 705

Query: 507  SFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRS 566
            + + L  L  +   +E +LA            R + E E  +RE      L+ +      
Sbjct: 706  ATTQLEQLHQEAKRQEEVLA------------RAVQEKEALVRE---KAALEVRLQAVER 750

Query: 567  FRPYRAEDND--SYASEIKELQLVLAEAHDSLRGL---QEQLSQERQLRKEEADNFNQKM 621
             R   AE     S A E+ E  L  A+  +S+  +   Q ++  +   + +E      + 
Sbjct: 751  DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRC 810

Query: 622  VQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
            ++L+ D +R+   +E +    +  R+L Q   ++++     E Q+  H   +  ++ +W 
Sbjct: 811  LKLELDTERSQAEQERD----AAARQLAQ---AEQEGKTALEQQKAAHEKEVNQLREKWE 863

Query: 682  LKR-WRQ---GKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQ---N 734
             +R W Q    K L S   + +E+  M+      E E I AQ  + +     +  Q    
Sbjct: 864  KERSWHQQELAKALESLEREKMEL-EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLE 922

Query: 735  TPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMEL 794
            T  E +  L  +  T KEL    +   R   +++ Q  K + T    + +L+   +Q EL
Sbjct: 923  TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ--EAQREL 980

Query: 795  KTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQL------------QISER 842
            K       R   D  AALQ E         +    V +L  QL            ++ E+
Sbjct: 981  K----EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036

Query: 843  -NWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETR 901
               +QE  ++ + L+ EK  +   + E + RL  LQ+A     ++  EL       +E +
Sbjct: 1037 LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS---IRQQELSALRQDMQEAQ 1093

Query: 902  SEKIHDKEAVSEVEL 916
             E+   KE  +++EL
Sbjct: 1094 GEQ---KELSAQMEL 1105



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 201/923 (21%), Positives = 338/923 (36%), Gaps = 213/923 (23%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLE---QDV 65
            +EE   +LQ    Q+        +L   L+  ER     +Q  Q++ EL R  E   QD+
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQ--ERDQEVKSQREQIE-ELQRQKEHLTQDL 1653

Query: 66   KVSKDISMRLHKE-LEVVEKKRAR----LEEENEE----LRQRLIETELAKQVLQTELER 116
            +  +D  + L KE ++V+E +R R    LEE+ E+    LR+R  E    +Q++Q   E 
Sbjct: 1654 E-RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712

Query: 117  PREHSLKKRGTRSLGKADKKTLVQEDSADLKCQ--------------------LHFAKEE 156
             +  S  +RG+        K ++++   +++CQ                    LH    E
Sbjct: 1713 GKGPSKAQRGSLE----HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE 1768

Query: 157  SALMC----KKLTKLAKENDSMKEE-LLKYRSLYGDLDSALSA----EELADAPHSRETE 207
            ++L+     +++  L ++    +E+  LK +SL   LD A  A    ++  +A    + +
Sbjct: 1769 TSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQ 1828

Query: 208  LKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGEC 267
             +   + V+E+A+ L   + +  +  +    E+ D K+        +AR           
Sbjct: 1829 AQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE--------QAR---------RL 1871

Query: 268  GESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSC--- 324
             E LA   R +Q +EE    LR  S E E     L  + A+   EHE++    +DS    
Sbjct: 1872 EEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQA 1931

Query: 325  -SVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAE 383
             +VL E  Q EL A +                             A  QS+R   E    
Sbjct: 1932 QAVLKERDQ-ELEALR-----------------------------AESQSSRHQEEA--- 1958

Query: 384  AGDSAQCVPAPLGETH------ESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADAN 437
            A   A+ +   LG+ H      E H +      +AE+   L    A +  ++D   A + 
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLL-----EQAELSRSLEASTATLQASLDACQAHSR 2013

Query: 438  GFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVL 497
                 LR+  + E  D  L    D                    +QQ   A  ++ +   
Sbjct: 2014 QLEEALRI-QEGEIQDQDLRYQED--------------------VQQLQQALAQRDE--- 2049

Query: 498  GCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDL 557
               ++ QQE              +E LL K L    Q          E  I+E    G  
Sbjct: 2050 --ELRHQQE--------------REQLLEKSLAQRVQ----------ENMIQEKQNLG-- 2081

Query: 558  DSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNF 617
                      +    E+       ++ELQL LA+    +  L+E   Q   L      + 
Sbjct: 2082 ----------QEREEEEIRGLHQSVRELQLTLAQKEQEILELRE-TQQRNNLEALPHSHK 2130

Query: 618  NQKMVQ--LKEDQQRALLRREFE-LQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLL 674
               M +  LK D     L+RE E LQ+   Q    +  W ++   L     Q K +   L
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190

Query: 675  FMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQN 734
              ++  FL    Q  VL  + +   +     EL L     E    HS     T +  ++ 
Sbjct: 2191 -QEVAMFL----QASVLERDSE---QQRLQDELELTRRALEKERLHSPGATSTAELGSRG 2242

Query: 735  TPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMEL 794
                 +  ++ ++          +  R+ L  LQQ    A A  E +R+ L+ H  Q+  
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ----AVARLEIDRSRLQRHNVQL-- 2296

Query: 795  KTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVER 854
                          ++ L++   E++ L  E+  A       L+IS+   S    Q    
Sbjct: 2297 --------------RSTLEQVERERRKLKREAMRAAQ--AGSLEISKATASSPTQQ---D 2337

Query: 855  LQGEKQQVEQQVKELQNRLSQLQ 877
             +G+K    + V ELQ  +  LQ
Sbjct: 2338 GRGQKNSDAKCVAELQKEVVLLQ 2360



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 205/996 (20%), Positives = 388/996 (38%), Gaps = 165/996 (16%)

Query: 2    LEMRDVYMEEDVYQLQELRQ----QLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGEL 57
            L +  V + + + QL+E  Q    +++ A +    LQ  L +AE+R        +   E 
Sbjct: 608  LALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR-------EALWEK 660

Query: 58   IRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERP 117
               LE  ++ +++    L  +L  ++       EE EE++++L E+   ++   T+LE+ 
Sbjct: 661  NTHLEAQLQKAEEAGAELQADLRDIQ-------EEKEEIQKKLSESRHQQEAATTQLEQL 713

Query: 118  REHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEE 177
             + + ++    +    +K+ LV+E +A L+ +L   + +   + ++L  L     S  +E
Sbjct: 714  HQEAKRQEEVLARAVQEKEALVREKAA-LEVRLQAVERDRQDLAEQLQGL-----SSAKE 767

Query: 178  LLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLR 237
            LL+         S   A++        + +L+V ++ V +   ++   +  L++E    R
Sbjct: 768  LLE--------SSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTER 819

Query: 238  AEMDDMKDHGGGCGGPEARLAFSALGGGECG--ESLAELRR--------HLQFVEEEAEL 287
            ++ +  +D          +   +AL   +    + + +LR         H Q + +  E 
Sbjct: 820  SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES 879

Query: 288  LRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDS-CSVLSE-------------PSQE 333
            L R   ELE + K    E+   +++ E +   +E + C +  E              +Q+
Sbjct: 880  LEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK 939

Query: 334  ELAAAKLQIGEL--SGKVKKL--QYENRVLLSNLQ-------------RCDLASCQ-STR 375
            ELA A  Q+  L    KV+KL  Q    +L + LQ             R DLA+ Q  + 
Sbjct: 940  ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999

Query: 376  PMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVAD 435
             +L+   +     + + + L    +S      R  E EV   LRE     ++    L  +
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQ-----RLVEQEVQEKLRETQE-YNRIQKELERE 1053

Query: 436  ANGFTAGL-----RLCLDNECADFRLHE----APDNSEGPRDTKLIHA--ILVRLSVLQQ 484
                T  L     RL +  E    R  E      D  E   + K + A   L+R  V ++
Sbjct: 1054 KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK 1113

Query: 485  ELNAFTRKADAV--LGCSVKEQQESFSSLPPLGSQGLSKEILL------AKDLGSDFQPP 536
            E +   ++A  +  L  S   +Q+  +SL    ++    ++ L       + L ++ QP 
Sbjct: 1114 EADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG 1173

Query: 537  DFRDLPEWEPRIREAFRTG---------DLDSKPDPSRSFRPYRAEDNDSYASEIKELQL 587
            +          +  A +           +L    D + S      + N +  S  K   L
Sbjct: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA-RSLFKRGPL 1232

Query: 588  VLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKE-----DQQRALLRREF-ELQS 641
            + A + +++     +L Q+    ++  D    ++ +L+E     + +++ +  E  +LQ 
Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292

Query: 642  LSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF-LKRWRQGKVLPSEGDDFLE 700
               Q + E+  W  ++N L  E  +       L  +LR   L+R              +E
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQR--------------ME 1338

Query: 701  VNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDE 760
                +EL L   +E + AQ    +A   ++  Q          A     L+E    LR  
Sbjct: 1339 AQGEREL-LQAAKENLTAQVEHLQAAVVEARAQ----------ASAAGILEE---DLRTA 1384

Query: 761  RRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQ 820
            R  L    ++        E+ER   +    Q ELK  +G           ALQ       
Sbjct: 1385 RSALKLKNEEV-------ESERERAQALQEQGELKVAQG----------KALQENLALLT 1427

Query: 821  HLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAA 880
              LAE    V  L  Q+Q  E+    +K  L E L  + ++  Q+V   Q ++ +L+K  
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAAL-ELLSLDLKKRNQEVDLQQEQIQELEKCR 1486

Query: 881  DPWVLKHSELEKQDNSWKET-RSEKIHDKEAVSEVE 915
               VL+H  +  Q+   K T + E+I + E   E +
Sbjct: 1487 S--VLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 208/1005 (20%), Positives = 373/1005 (37%), Gaps = 176/1005 (17%)

Query: 19   LRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKE 78
            L  +L +  +T   LQ RLR+AE + + A    Q + EL++  ++++    +     H +
Sbjct: 1311 LESELMELHETMASLQSRLRRAELQRMEA----QGERELLQAAKENLTAQVE-----HLQ 1361

Query: 79   LEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTL 138
              VVE +         E   R   + L  +  + E ER R  +L+++G   L  A  K L
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG--ELKVAQGKAL 1419

Query: 139  VQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL------LKYRSLYGDLDSAL 192
             QE+ A L   L   +EE   +  ++ +L K+ +  K  L      LK R+   DL    
Sbjct: 1420 -QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478

Query: 193  SAE---------ELADAPHSRETELKVHLKLVEE-------EANLLSRRIVELEVENRGL 236
              E          L  A   RE +L V  + + E       + N+L  +++ELE +++ +
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538

Query: 237  RAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE 296
             ++   ++D                            L++ L  +E  A  L  +  ++E
Sbjct: 1539 ESQRGQVQD----------------------------LKKQLVTLECLALELEENHHKME 1570

Query: 297  DQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGK----VKKL 352
             Q KL+  EL   R      VAL+  +  +  E   +EL A   QI +L        ++L
Sbjct: 1571 CQQKLI-KELEGQRETQR--VALTHLTLDL--EERSQELQAQSSQIHDLESHSTVLAREL 1625

Query: 353  QYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREA 412
            Q  ++ + S  QR  +   Q  +  L  D E  D    +     +  E    R  +  E 
Sbjct: 1626 QERDQEVKS--QREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683

Query: 413  E---VLPGLREQAALVSKAIDVL---VADANGFTAGLRLCLDNECADFRLHEAPDNSEGP 466
            +   +   LRE+   ++    ++     +  G +   R  L++     +L       E  
Sbjct: 1684 DLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH----MKLILRDKEKEVE 1739

Query: 467  RDTKLIHAILVRLSVLQQELNAFTRKA-DAVLGCSVKEQQ--------ESFSSLPPLGSQ 517
               + IH +      L+Q+L    RK  +  L  S +EQ+        +       L  Q
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799

Query: 518  GLSKEI------LLAKDLGSDFQPPDFRDLPEWEPRIREAF----------------RTG 555
             L  ++      L  +D   +    + +     E R++E                  R G
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859

Query: 556  DLDSKPDPSRSFRPYRAEDN---DSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE 612
            +L    + +R      A +     +    + +L+    E   +L  LQ+Q +++ Q  + 
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919

Query: 613  EA----DNFNQKMVQLKE-DQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQF 667
            E     D++ Q    LKE DQ+   LR E +      +    +    QE       + Q 
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG 1979

Query: 668  KHNFLLLFMKLRWFLK------------------------RWRQGKVLPSEGDDFLEVNS 703
            K   LL   +L   L+                        R ++G++   +     +V  
Sbjct: 1980 KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039

Query: 704  MKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADM-----KVTLKELCWLLR 758
            +++  L   +EE+  Q  + +     S  Q      I+   ++     +  ++ L   +R
Sbjct: 2040 LQQA-LAQRDEELRHQQ-EREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVR 2097

Query: 759  DERRGLTELQQQFAKAKATWETERAELKGH---TSQMELKTGKGAGERAGPDWKAALQRE 815
            + +  L + +Q+  + + T +    E   H   TS ME ++ K          +  LQRE
Sbjct: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL------DSLEPRLQRE 2151

Query: 816  REEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQ 875
             E  Q  L ++ +  +E   + Q    + +Q K   V  LQ     ++  V E   R S+
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKAS-VSSLQEVAMFLQASVLE---RDSE 2207

Query: 876  LQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNG 920
             Q+  D   L    LEK          E++H   A S  ELG  G
Sbjct: 2208 QQRLQDELELTRRALEK----------ERLHSPGATSTAELGSRG 2242



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 37/148 (25%), Positives = 64/148 (43%), Gaps = 11/148 (7%)

Query: 75   LHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKAD 134
            L + +  +E  R+RL+  N +LR  L + E  ++ L+ E  R  +      G+  + KA 
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ-----AGSLEISKAT 2329

Query: 135  KKTLVQED-----SADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLD 189
              +  Q+D     ++D KC     KE   L  +   +  ++ D +       R L G L 
Sbjct: 2330 ASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAG-LH 2388

Query: 190  SALSAEELADAPHSRETELKVHLKLVEE 217
             +LS   LA A     T L+   + ++E
Sbjct: 2389 HSLSHSLLAVAQAPEATVLEAETRRLDE 2416



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 84/436 (19%), Positives = 166/436 (38%), Gaps = 84/436 (19%)

Query: 575 NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRK--------------EEADNFNQK 620
           N +   ++++L +  + A D L   + Q   E++  K               E   F + 
Sbjct: 131 NKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRH 190

Query: 621 MVQLKEDQQRALLRREFELQSLSLQR-----RLEQKFWSQEKNMLVQESQQFKHNFLLLF 675
            +++K    R L+  + E   LS        RL     S+E N   +   +     LLL 
Sbjct: 191 FLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLL 250

Query: 676 MKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNT 735
            K +   K   +         + +++ S  +L    E+ E+  + ++  A    S  QN 
Sbjct: 251 AKTQELEKEAHE------RSQELIQLKSQGDL----EKAELQDRVTELSALLTQSQKQN- 299

Query: 736 PNEYIKTLADMKVTLK--------------ELCWLLRDERRGLTELQQQFAKAKATWETE 781
             +Y K +  ++ T++               L    ++E+  L ++ +   +        
Sbjct: 300 -EDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDN 358

Query: 782 RAELKGHTSQMELKTGKGA------GERAGPDWKAALQREREEQQHLLAESYSAVMELTR 835
            A+  GH + +EL +   +       ++A    ++ L R R+  Q L  +  +   E   
Sbjct: 359 IAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDL-RQQLAGCQEAVN 417

Query: 836 QLQISERNWSQEKLQL---VERLQGEKQQVEQQVKELQNRLSQLQK-------------- 878
            LQ     W +E   L   +++L GE+  +  Q  +LQ  +  L K              
Sbjct: 418 LLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ 477

Query: 879 -----AADPWVLK--HSELEKQDNS---WKETRSEKIH----DKEAVSEVELGGNGLKRT 924
                  + W L+  + EL+ Q +S    KE + E++H    ++E + E+ L G   K++
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM-LMGLEAKQS 536

Query: 925 KSVSSMSEFESLLDCS 940
           +S+S +      L+ S
Sbjct: 537 ESLSELITLREALESS 552



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 183/885 (20%), Positives = 341/885 (38%), Gaps = 166/885 (18%)

Query: 105 LAK-QVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKK 163
           LAK Q L+ E     +  ++ +    L KA+ +  V E SA L  Q     E+   M K 
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA-LLTQSQKQNEDYEKMIKA 308

Query: 164 LTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLS 223
           L +  +  ++   EL+++       +++LS     +    ++    +   +VEE  N+  
Sbjct: 309 LRETVEILETNHTELMEH-------EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361

Query: 224 RRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEE 283
               E  +E         D +D           L  S L      +++ +LR+ L   +E
Sbjct: 362 GSGHENSLELDSSIFSQFDYQD-----ADKALTLVRSVLTRRR--QAVQDLRQQLAGCQE 414

Query: 284 EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIG 343
              LL++   + E++ K L   L K   E +     + D                + ++ 
Sbjct: 415 AVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVD---------------LQGEVD 459

Query: 344 ELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHA 403
            LS + + LQ     L   L+  +  + +  R  +E   + GDSAQ       E  E H 
Sbjct: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ-GDSAQGQKEEQQE--ELHL 516

Query: 404 VRLCRAREAEVLPGLR-EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDN 462
               R R  E+L GL  +Q+  +S+ I +  A  +    G  L  +       L  A  +
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576

Query: 463 ------SEGPRDTKL--IHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL 514
                 SE    T++  + A  V+LS L + L       +  L   ++E+ +S  S    
Sbjct: 577 IAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL-LQLEEENQSVCSRMEA 635

Query: 515 GSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAED 574
             Q  +   +               DL E E R REA                     E 
Sbjct: 636 AEQARNALQV---------------DLAEAEKR-REALW-------------------EK 660

Query: 575 NDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLR 634
           N    +++++ +   AE    LR +QE+   + +++K+ +++ +Q+     + +Q   L 
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEE---KEEIQKKLSESRHQQEAATTQLEQ---LH 714

Query: 635 REFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSE 694
           +E + Q   L R +      QEK  LV+E    +       ++L+  ++R RQ      +
Sbjct: 715 QEAKRQEEVLARAV------QEKEALVREKAALE-------VRLQ-AVERDRQDLAEQLQ 760

Query: 695 GDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV-TLKEL 753
           G     ++S KEL   +E     AQ             QN+  E  K   ++++ T+ + 
Sbjct: 761 G-----LSSAKEL---LESSLFEAQQ------------QNSVIEVTKGQLEVQIQTVTQA 800

Query: 754 CWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQ 813
             +++ E R L        K +   E  +AE +   +  +L   +  G+ A    KAA +
Sbjct: 801 KEVIQGEVRCL--------KLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE 852

Query: 814 REREEQQHLLAESYSAVMELTRQLQISERNWSQEKL-QLVERLQGEKQQVEQQVKELQNR 872
           +E  +                R+    ER+W Q++L + +E L+ EK        EL+ R
Sbjct: 853 KEVNQ---------------LREKWEKERSWHQQELAKALESLEREKM-------ELEMR 890

Query: 873 LSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSE 932
           L + Q          +E+E      +E R++    + A+ +++L     + +   + +  
Sbjct: 891 LKEQQ----------TEMEAIQAQREEERTQA---ESALCQMQLETEKERVSLLETLLQT 937

Query: 933 FESLLDCSPYL--AGGDARGKKLPNNPAFGFVSSEPGDPEKDTKE 975
            + L D S  L     D + +KL      G + ++  + +++ KE
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 79/348 (22%), Positives = 140/348 (40%), Gaps = 69/348 (19%)

Query: 633 LRREFELQSLSLQRRLEQK---FWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQ-- 687
           L+   E Q L+LQ+++ +     W + KN   QE+QQ +   +          + W Q  
Sbjct: 16  LQLVLEEQVLALQQQMAENQAASWRKLKNS--QEAQQRQATLVRKLQAKVLQYRSWCQEL 73

Query: 688 -------GKVLPSEGDDFLEVNSMKELYLLMEEE--------EINAQ---HSD-----NK 724
                  G  +P   ++  E N + EL + +EEE        E+N Q   H +     NK
Sbjct: 74  EKRLEATGGPIPQRWENVEEPN-LDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNK 132

Query: 725 ACTGD------SWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTEL-------QQQF 771
           A   D       W++   +E ++  +  ++  +     L+ E   L  L       ++ F
Sbjct: 133 ALREDVEKLTVDWSR-ARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191

Query: 772 AKAKATWETERAELKGHTSQME-------LKTGKGAGERAGPDWKAALQREREEQQHLLA 824
            + K+  + +  ELK    ++        L+   GA  R  P+    +   RE  Q LL 
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSRE-PNGSGRMDG-REPAQLLL- 248

Query: 825 ESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWV 884
                ++  T++L+      SQE +QL  +   EK +++ +V EL   L+Q QK      
Sbjct: 249 -----LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQK------ 297

Query: 885 LKHSELEKQDNSWKETRS--EKIHDKEAVSEVELGGNGLKRTKSVSSM 930
            ++ + EK   + +ET    E  H +    E  L  N  +   S+  +
Sbjct: 298 -QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV 344


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 209/984 (21%), Positives = 389/984 (39%), Gaps = 178/984 (18%)

Query: 16   LQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRL 75
            +Q+L +QLD+     + LQ     AE +              I+ +E+++ + +D + + 
Sbjct: 952  IQDLEEQLDEEEGARQKLQLEKVTAEAK--------------IKKMEEEILLLEDQNSKF 997

Query: 76   HKELEVVEKKRARLEE---ENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGK 132
             KE +++E + A       E EE  + L +    ++V+ ++LE   +   K R  + L K
Sbjct: 998  IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR--QELEK 1055

Query: 133  ADKK-----TLVQEDSADLKCQ-----LHFAKEESAL---MCKKLTKLAKENDSMK---E 176
            A +K     T +Q+  A+L+ Q     L  AK+E  L   + +   +   +N+++K   E
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 177  ELLKYRSLYGDLDSALSAE--------ELADAPHSRETELKVHLKLVEEEANLLSRRIVE 228
               +   L  D +S  ++         +L++   + +TEL+  L     +  L ++R  E
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175

Query: 229  -------LEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFV 281
                   LE E +   A++ DM+                A    E  E L + +R    +
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQR-------------HATALEELSEQLEQAKRFKANL 1222

Query: 282  EEEAELLRRSSAELEDQNKLLLNELAKFRSEHE---LDVALSEDSCSV---------LSE 329
            E+  + L   + EL  + K+L  +  K  SEH+   LD  + E    V         L+E
Sbjct: 1223 EKNKQGLETDNKELACEVKVL--QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280

Query: 330  PS---QEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD 386
             +   Q EL      + E   K  K   +   L S LQ       + TR  L   +    
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340

Query: 387  SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFT-AGLRL 445
              +   +   +  E    R  +  E +VL  L+ Q A   K +D  +        A  +L
Sbjct: 1341 LEEEKNSLQEQQEEEEEAR--KNLEKQVL-ALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397

Query: 446  CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKAD--AVLGCSVKE 503
              D E    RL E     +    TK         + LQQEL+  T   D    +  ++++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTK---------NRLQQELDDLTVDLDHQRQVASNLEK 1448

Query: 504  QQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTG-------D 556
            +Q+ F  L             LA++     +  + RD  E E R +E             
Sbjct: 1449 KQKKFDQL-------------LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495

Query: 557  LDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADN 616
            L++K +  R  +  RA+  D  +S+  ++   + E   S R L++Q+ + R   +E  D 
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSK-DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554

Query: 617  FNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFM 676
                 +Q  ED   A LR E  +Q++  Q          E+++  ++ Q  +   LL+  
Sbjct: 1555 -----LQATED---AKLRLEVNMQAMKAQF---------ERDLQTRDEQNEEKKRLLI-- 1595

Query: 677  KLRWFLKRWRQGKVLPSEGDD-----FLEVNSMKELYLLMEEEEINAQHSDNKACTGDSW 731
                     +Q + L +E +D      L V S K++ + +++ E   + + NKA      
Sbjct: 1596 ---------KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA-NKA------ 1639

Query: 732  TQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQ 791
                 +E IK L  ++  +K+    L + R    E+  Q  +++   ++  AE+      
Sbjct: 1640 ----RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI------ 1689

Query: 792  MELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQL 851
            ++L+    + ERA        +R  E+++  LA+  +        L   +R       QL
Sbjct: 1690 LQLQEELASSERA--------RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741

Query: 852  VERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAV 911
             E L+ E+  +E      +    Q+         + S  +K DN+ ++   +    K  +
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801

Query: 912  SEVELGGNGLKRTKSVSSMSEFES 935
             E+E    G  ++K  +++S  E+
Sbjct: 1802 QELE----GAVKSKFKATISALEA 1821



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 197/969 (20%), Positives = 387/969 (39%), Gaps = 163/969 (16%)

Query: 15   QLQELRQQLDQASKTCRILQYRLR-------KAERRSLRAAQTGQVDGELIRGLEQDVKV 67
            +L+E+ ++  Q  +   IL  +L+       +AE    R A   Q   E++  LE  V+ 
Sbjct: 874  ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE 933

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGT 127
             ++ +       ++++ ++ +++   ++L ++L E E A+Q LQ E         K    
Sbjct: 934  EEERN-------QILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE---------KVTAE 977

Query: 128  RSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRS---- 183
              + K +++ L+ ED      +     E+    C   ++LA+E +  K  L K R+    
Sbjct: 978  AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS--SQLAEEEEKAK-NLAKIRNKQEV 1034

Query: 184  LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDM 243
            +  DL+  L  EE          EL+   + ++ E   L  +I EL+ +   L+ ++   
Sbjct: 1035 MISDLEERLKKEE------KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088

Query: 244  KDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLL 303
            ++      G  AR     L      + + EL+  +  ++E+ E  + S  + E Q + L 
Sbjct: 1089 EEE---LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145

Query: 304  NELAKFRSEHE--LDVALS--------EDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQ 353
             EL   ++E E  LD   +        E   + L +  +EE    + QI ++  +     
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATAL 1205

Query: 354  YENRVLLSNLQRCDLASCQSTRPMLETD-AEAGDSAQCVPAPLGETHESHAVRLCRARE- 411
             E    L   +R   A+ +  +  LETD  E     + +     E+         + +E 
Sbjct: 1206 EELSEQLEQAKRFK-ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264

Query: 412  -AEVLPGLREQAALVSKA---------IDVLVADANGFTAGLRLCLDNECADFRLHEAPD 461
             A+V  G R +  L  KA         +  L+ +A     G++   D    + +L +  +
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE--KKGIKFAKDAASLESQLQDTQE 1322

Query: 462  NSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSK 521
              +     KL   +  R+  L++E N            S++EQQE          + L K
Sbjct: 1323 LLQEETRQKL--NLSSRIRQLEEEKN------------SLQEQQEEEEE----ARKNLEK 1364

Query: 522  EILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASE 581
            ++L  +   +D +     DL             G ++S  +  +       +D ++ +  
Sbjct: 1365 QVLALQSQLADTKKKVDDDL-------------GTIESLEEAKKKL----LKDAEALSQR 1407

Query: 582  IKELQLVLAEAHDSLRGLQEQ-------LSQERQLR---KEEADNFNQKMVQLK------ 625
            ++E  L   +   +   LQ++       L  +RQ+    +++   F+Q + + K      
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467

Query: 626  -EDQQRALLR-REFELQSLSLQRRLE------QKFWSQEKNM------LVQESQQFKHNF 671
             E++ RA    RE E ++LSL R LE      ++F  Q K +      L+        N 
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527

Query: 672  LLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSW 731
              L    R   ++  + +    E +D L+     +L L +  + + AQ         D  
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE------RDLQ 1581

Query: 732  TQNTPNEYIKTLADMKVTLKELCWLLRDERR--------------GLTELQQQFAKAKAT 777
            T++  NE  K L   +V  +EL   L DER+               L +L+ Q   A   
Sbjct: 1582 TRDEQNEEKKRLLIKQV--RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639

Query: 778  WETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQL 837
             +    +L+   +QM+    +    RA  D   A  +E E++   L    + +++L  +L
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK---LKSLEAEILQLQEEL 1696

Query: 838  QISE---RNWSQEKLQLVERLQGE---KQQVEQQVKELQNRLSQLQKAADPWVLKHSELE 891
              SE   R+  QE+ +L + +      K  +  + + L+ R++QL++  +    + S +E
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE---EQSNME 1753

Query: 892  KQDNSWKET 900
              ++ +++T
Sbjct: 1754 LLNDRFRKT 1762



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 178/893 (19%), Positives = 348/893 (38%), Gaps = 126/893 (14%)

Query: 56   ELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRL-IETELAKQVLQTEL 114
            E ++  ++++   K+   ++  ELE +E+K  +L EE   L ++L  ETEL     + E 
Sbjct: 852  EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL---FAEAEE 908

Query: 115  ERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM 174
             R R              A KK  ++E   DL+ ++   +E               N  +
Sbjct: 909  MRAR-------------LAAKKQELEEILHDLESRVEEEEE--------------RNQIL 941

Query: 175  KEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANL--LSRRIVELEVE 232
            + E  K ++   DL+  L  EE A          K+ L+ V  EA +  +   I+ LE +
Sbjct: 942  QNEKKKMQAHIQDLEEQLDEEEGA--------RQKLQLEKVTAEAKIKKMEEEILLLEDQ 993

Query: 233  NRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGES----LAELRRHLQFVEEEAELL 288
            N     E   M+D    C    A     A    +        +++L   L+  E+  + L
Sbjct: 994  NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053

Query: 289  RRSSAELEDQNKLLLNELAKFRSE-HELDVALS---EDSCSVLSEPSQEELAA--AKLQI 342
             ++  +L+ +   L +++A+ +++  EL + L+   E+    L+    E L    A   +
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113

Query: 343  GELSGKVKKLQ--YENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHE 400
             EL  ++ +LQ  +E+     N               L+T+ E           L    E
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173

Query: 401  SHAVRLCRAREAEV------LPGLREQAALVSKAIDVLVADANGFTAGLR-----LCLDN 449
                 L +A E E       +  +R++ A   + +   +  A  F A L      L  DN
Sbjct: 1174 QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233

Query: 450  E---CADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAV---LGCSVKE 503
            +   C    L +    SE  R          +L    QEL+A   + D +   L     +
Sbjct: 1234 KELACEVKVLQQVKAESEHKRK---------KLDAQVQELHAKVSEGDRLRVELAEKASK 1284

Query: 504  QQESFSSLPPLGSQGLSKEILLAKDLGS-DFQPPDFRDLPEWEPR--IREAFRTGDLDSK 560
             Q    ++  L  +   K I  AKD  S + Q  D ++L + E R  +  + R   L+ +
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344

Query: 561  PDPSRSFRPYRAEDNDSYASEIKELQLVLAEAH---DSLRGLQEQLSQERQLRKEEADNF 617
             +  +  +    E   +   ++  LQ  LA+     D   G  E L + ++   ++A+  
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL 1404

Query: 618  NQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQ---ESQQFKHNFLLL 674
            +Q++      +++AL   + E     LQ+ L+      +    V    E +Q K + LL 
Sbjct: 1405 SQRL------EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458

Query: 675  FMK---LRWFLKRWR-QGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDS 730
              K    R+  +R R + +    E        +++E   L  +EE   Q+   +A   D 
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEE--ALEAKEEFERQNKQLRADMED- 1515

Query: 731  WTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTS 790
               ++ ++  K + +++ + + L   + + R  L EL+ +         TE A+L+   +
Sbjct: 1516 -LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ------ATEDAKLRLEVN 1568

Query: 791  QMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQ 850
               +              KA  +R+ + +     E    +++  R+L+    +  +++  
Sbjct: 1569 MQAM--------------KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614

Query: 851  LVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSE 903
             V      K+++E  +K+L+ ++    KA D  + +  +L+ Q   ++    E
Sbjct: 1615 AV----ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 207/964 (21%), Positives = 411/964 (42%), Gaps = 136/964 (14%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL-EQDVKV 67
            +EE   QL + +Q+L+Q     +    RL++     L  A++ ++  + +  L E+ V+V
Sbjct: 267  LEEKTEQLLDCKQELEQMEIELK----RLQQENMNLLSDARSARMYRDELDALREKAVRV 322

Query: 68   SKDIS--MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKR 125
             K  S   R  + L  +E  +AR+EE  E+  Q L+ET   K +L+ +LE          
Sbjct: 323  DKLESEVSRYKERLHDIEFYKARVEELKED-NQVLLET---KTMLEDQLE---------- 368

Query: 126  GTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM----KEELLKY 181
            GTR+  ++DK   +++++  LK +LH  + E  +  KK+ +L +EN ++    K+ + + 
Sbjct: 369  GTRA--RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426

Query: 182  RSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMD 241
              L  +L+      EL++AP            L  E   L S R+++LE+EN+ L   ++
Sbjct: 427  LHLGWELEQISRTSELSEAPQK---------SLGHEVNELTSSRLLKLEMENQSLTKTVE 477

Query: 242  DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKL 301
            +++       G  +++        +  +    L + ++ +E E    ++S    ++ +K 
Sbjct: 478  ELRTTVDSVEGNASKIL-------KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530

Query: 302  LLNELAKFRSEHELDVALSEDSCSVLSEPSQ--EELAAAKLQIGELS--GKVKKLQYENR 357
            L+ E A+     E     SE    +L + ++   +  ++  Q  ++S   +VK ++ EN+
Sbjct: 531  LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 358  VLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAE-VLP 416
            +L  +++              ET ++     +     + +  E +  +  RA E E  L 
Sbjct: 591  ILHESIK--------------ETSSKL-SKIEFEKRQIKKELEHYKEKGERAEELENELH 635

Query: 417  GLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAIL 476
             L ++  L+ K I  L        A  +   + E  + +L +  D+ +    T  + ++ 
Sbjct: 636  HLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL--TFQLESLE 693

Query: 477  VRLSVLQQELNAFTRKADAVLGCSVK------EQQESFSSLPPLGSQGLSKEILLAKDLG 530
               S L +E     R  +++   S+K      E +E  S    L  +GL  E+L A    
Sbjct: 694  KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL-KKGL--ELLKASFKK 750

Query: 531  SDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLA 590
            ++     ++ L     R+++           + ++  +   +E  D    E + LQ  L 
Sbjct: 751  TERLEVSYQGLDIENQRLQKTLE--------NSNKKIQQLESELQD-LEMENQTLQKNLE 801

Query: 591  EAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSL-QRRLE 649
            E   S + L EQL +E +  ++E     +   QL+++ +R  LR++ E++  +L +  ++
Sbjct: 802  ELKISSKRL-EQLEKENKSLEQETSQLEKDKKQLEKENKR--LRQQAEIKDTTLEENNVK 858

Query: 650  QKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLE--VNSMKEL 707
                 +E   L +E   +K + + L              K L  E  + ++     +K L
Sbjct: 859  IGNLEKENKTLSKEIGIYKESCVRL--------------KELEKENKELVKRATIDIKTL 904

Query: 708  YLLMEE---EEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGL 764
              L E+   E++  Q  +N         +       + L D + T      LL  +    
Sbjct: 905  VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964

Query: 765  TELQQQFAKAK-ATWETERAELKGHTSQM--ELKTGKGAGERAGPDWKAALQREREEQQH 821
             +   +  + K A  E    E   +  Q+  ELKT K        +++A  QR+ EE+  
Sbjct: 965  LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK-------KNYEALKQRQDEERMV 1017

Query: 822  LLAESYSAV-MELTRQLQISERNWSQEKLQLVE------RLQGEKQQVEQQVKELQNRLS 874
              +   S    +  R+ Q + R   + K +L+E       LQ EKQ ++ Q+K+L+ + +
Sbjct: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077

Query: 875  QLQKAADPWVLKHSELEKQD-NSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEF 933
             LQ  A    L+   +  Q+ N+  +T++ K+       +VE   N    ++S S M++ 
Sbjct: 1078 NLQ--AQILALQRQTVSLQEQNTTLQTQNAKL-------QVE---NSTLNSQSTSLMNQN 1125

Query: 934  ESLL 937
              LL
Sbjct: 1126 AQLL 1129



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 198/952 (20%), Positives = 387/952 (40%), Gaps = 151/952 (15%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL 61
            LEM +  + + V   +ELR  +D           ++ K E+ + R ++  ++    I   
Sbjct: 465  LEMENQSLTKTV---EELRTTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQE 517

Query: 62   EQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPRE-- 119
            +Q ++  +++S  L KE       +A+LE+  E LR+    +E   ++L+ E E   +  
Sbjct: 518  KQSLQNCQNLSKDLMKE-------KAQLEKTIETLREN---SERQIKILEQENEHLNQTV 567

Query: 120  HSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELL 179
             SL++R   S  +A  K + +E+       LH + +E++    KL+K+  E   +K+EL 
Sbjct: 568  SSLRQRSQIS-AEARVKDIEKENKI-----LHESIKETS---SKLSKIEFEKRQIKKELE 618

Query: 180  KYRSLYGDLDSALSAEELADAPHSRETELKV------HLKLVEEEANLLSRRIVELEVEN 233
             Y+      +    AEEL +  H  E E ++      +LK+  E+   L +   ELE EN
Sbjct: 619  HYK------EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN 672

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVE---EEAELLRR 290
            R L+  +D  K+          +L        +  E   ELRR+++ ++    +   L+ 
Sbjct: 673  RKLKKTLDSFKNL-------TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725

Query: 291  SSAELEDQNKLLLNEL----AKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELS 346
             + ELE + + L   L    A F+    L+V  S     + ++  Q+ L  +  +I +L 
Sbjct: 726  ENKELESEKEQLKKGLELLKASFKKTERLEV--SYQGLDIENQRLQKTLENSNKKIQQLE 783

Query: 347  GKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRL 406
             +++ L+ EN+ L  NL+   ++S +  +   E  +   +++Q          E+  +R 
Sbjct: 784  SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR- 842

Query: 407  CRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGP 466
               ++AE+     +   L    + +   +    T    + +  E    RL E     E  
Sbjct: 843  ---QQAEI-----KDTTLEENNVKIGNLEKENKTLSKEIGIYKESC-VRLKEL--EKENK 891

Query: 467  RDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLA 526
               K     +  L  L+++L +   K   +     K   E       L   GL+KE LL 
Sbjct: 892  ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE-------LEKIGLNKERLL- 943

Query: 527  KDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQ 586
                 D Q  D       E ++    +   L+ K +   +    R E++ +Y  ++++  
Sbjct: 944  ----HDEQSTDDSRYKLLESKLESTLKK-SLEIKEEKIAALEA-RLEESTNYNQQLRQEL 997

Query: 587  LVLAEAHDSLRGLQEQ---------LSQERQLRKEEADNFNQKMVQLKE-----DQQRAL 632
              + + +++L+  Q++         +S E    + E+    ++++++K+     ++  A 
Sbjct: 998  KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057

Query: 633  LRRE-----------------FELQSLSLQRRL----EQKFWSQEKN--MLVQESQQFKH 669
            L+ E                  + Q L+LQR+     EQ    Q +N  + V+ S     
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117

Query: 670  NFLLLFMKLRWFLKRWRQGKVLPSEGDDFL-EVNSMKELY--LLMEEEEINAQHSDNKAC 726
            +  L+    +  +    Q   L +E +  + E   +K LY  L+ + E++   H      
Sbjct: 1118 STSLMNQNAQLLI----QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH------ 1167

Query: 727  TGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELK 786
                  +   +EY ++L     TLK     L  E R L +   Q  K K   E     LK
Sbjct: 1168 ------ERQASEY-ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220

Query: 787  GHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERN--- 843
                +M L       E    +  AA  ++   +   L  +YS +++ T  LQ   +N   
Sbjct: 1221 VEQEKMLL-------ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273

Query: 844  -WSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQD 894
              +  KL+   RL+ E  ++++Q ++L    ++L    +        LE+++
Sbjct: 1274 LLNNSKLEQT-RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1324



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 92/391 (23%), Positives = 164/391 (41%), Gaps = 36/391 (9%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVS 68
            +EE     Q+LRQ+L    K    L+ R  + E R ++++    + GE  +   +  + +
Sbjct: 983  LEESTNYNQQLRQELKTVKKNYEALKQR--QDEERMVQSSPP--ISGEDNKWERESQETT 1038

Query: 69   KDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTR 128
            +++ +++   L  VE+  A L+ E + L+ +L + E     LQ ++   +  ++  +   
Sbjct: 1039 REL-LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
            +  +     L  E+S  L  Q      ++A +  + + L  EN+S+ +E    +SLY   
Sbjct: 1098 TTLQTQNAKLQVENST-LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY--- 1153

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
            DS +   E  +  H R+     +  L+ +   L S     LEVE+R L    + +    G
Sbjct: 1154 DSLIKDHEKLELLHERQA--SEYESLISKHGTLKSAH-KNLEVEHRDLEDRYNQLLKQKG 1210

Query: 249  GCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAK 308
                 E  L        E  + L E + H + V  E + L   +  L      LL E   
Sbjct: 1211 QLEDLEKMLKV------EQEKMLLENKNH-ETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263

Query: 309  FRSEH----------ELDVALSEDSCSVLSEPSQE-ELAAAKL--QIGELSGKVKKLQYE 355
             +++H          +L+    E   S L E  Q+ ++ + KL  Q   LS     L+ E
Sbjct: 1264 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1323

Query: 356  NRVLLSNLQRCDLASCQSTRPMLETDAEAGD 386
            NR LL  +Q   L      R +LE + E+ D
Sbjct: 1324 NRHLLDQIQTLML----QNRTLLEQNMESKD 1350



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 145/721 (20%), Positives = 291/721 (40%), Gaps = 127/721 (17%)

Query: 208 LKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGP-----EARLAFSAL 262
           + +HLK + +E +  S  I+EL  E  GL             CG P     E+R   S  
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV- 251

Query: 263 GGGECGESLAELRRHLQFVEEEAELLRRSSAELE----------DQNKLLLNELAKFRSE 312
              E  ++ A++RR  Q +EE+ E L     ELE           +N  LL++    R  
Sbjct: 252 ---ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308

Query: 313 HELDVALSEDSCSVLSEPSQEELAAAKLQIGEL---SGKVKKLQYENRVLLSNLQRCDLA 369
            +   AL E +  V  +  + E++  K ++ ++     +V++L+ +N+VLL         
Sbjct: 309 RDELDALREKAVRV--DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL--------- 357

Query: 370 SCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGL--REQAALVSK 427
               T+ MLE   E     +     L E  + +     +  + E+   +  ++   L+ +
Sbjct: 358 ---ETKTMLEDQLE---GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 428 AIDVLVADANGFTAGLRLC--LDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQE 485
            + + +A        L L   L+       L EAP  S G    +L  + L++L +  Q 
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471

Query: 486 LNAFTRKADAVLGCSVKEQQESFSSLPPL--GSQGLSKEI-LLAKDLGSDFQPPD----- 537
           L     K    L  +V   + + S +  +   +Q LSK++ +L  ++  + Q        
Sbjct: 472 LT----KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527

Query: 538 FRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEA----- 592
            +DL + + ++ +   T  L    +          E  +   S +++   + AEA     
Sbjct: 528 SKDLMKEKAQLEKTIET--LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585

Query: 593 -------HDSLRGLQEQLSQ---ERQLRKEEADNFNQKMVQLKE-DQQRALLRREFELQS 641
                  H+S++    +LS+   E++  K+E +++ +K  + +E + +   L +E EL  
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL-- 643

Query: 642 LSLQRRLEQ-KFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLE 700
             LQ+++   K   ++   L QE+ + +              +  +  K L S  +   +
Sbjct: 644 --LQKKITNLKITCEKIEALEQENSELER-------------ENRKLKKTLDSFKNLTFQ 688

Query: 701 VNSMKELYLLMEEEEINAQHS-DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRD 759
           + S+++    ++EE +  + + ++  C                +A +++  KEL      
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCAS------------MKMAQLQLENKELESEKEQ 736

Query: 760 ERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQ 819
            ++GL  L+  F K      TER E+      +E                  LQ+  E  
Sbjct: 737 LKKGLELLKASFKK------TERLEVSYQGLDIE---------------NQRLQKTLENS 775

Query: 820 QHLLAESYSAVMELTRQLQISERNWSQEKL--QLVERLQGEKQQVEQQVKELQNRLSQLQ 877
              + +  S + +L  + Q  ++N  + K+  + +E+L+ E + +EQ+  +L+    QL+
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835

Query: 878 K 878
           K
Sbjct: 836 K 836


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 210/953 (22%), Positives = 374/953 (39%), Gaps = 146/953 (15%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKA---------ERRSLRAAQT------GQVD 54
            E+   ++Q LR   +  S+    L + L+ A         ER  L+AAQ        +++
Sbjct: 585  EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644

Query: 55   GELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL 114
             E    ++   +V +++  R H++LE +E KR+ L +E  E+R+ L    L + +LQ E 
Sbjct: 645  EEQEDAVQDGARVRRELE-RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAE- 702

Query: 115  ERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM 174
                    K     +L KA      +    +L+  +   + E A +   L+KL+  N+S+
Sbjct: 703  --------KAEVAEALTKA------EAGRVELELSMTKLRAEEASLQDSLSKLSALNESL 748

Query: 175  KEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENR 234
             ++ L    L   L      EE   A   R+ + +    +  EE   L    +E EV  +
Sbjct: 749  AQDKLDLNRLVAQL------EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802

Query: 235  GLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAE 294
            GL   +   +         E +L        +  E LA+L R L   E+E E  RR    
Sbjct: 803  GLEGSLRVAEQAQEAL---EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR---- 855

Query: 295  LEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQY 354
             E Q ++   E A    E     AL+++   +       +L AA+ +   LS +  +L+ 
Sbjct: 856  -EAQRQVEALERAAREKE-----ALAKEHAGL-----AVQLVAAEREGRTLSEEATRLRL 904

Query: 355  ENRVL---LSNLQRCDLASCQSTRPMLETDAEA---------GDSA---QCVPAPLGET- 398
            E   L   L  +QR  LA  ++ R  LE + +A         G+ A   Q + A   +  
Sbjct: 905  EKEALEGSLFEVQR-QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS 963

Query: 399  --HESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECA--DF 454
               E  A +L +A E E    LREQ A   + +              RL  + E A  + 
Sbjct: 964  LDKELMAQKLVQA-EREAQASLREQRAAHEEDLQ-------------RLQREKEAAWREL 1009

Query: 455  RLHEAPDNSEGPRD-TKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPP 513
                A   S+  R+  +L+  +      L +E+ A  ++ D  L  +  E+Q++  SL  
Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQAL-SLKE 1068

Query: 514  LGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAE 573
                 LS++++  +   +       R   + + R  +   T  +++     R  R  R E
Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST--VNALTSELRDLRAQREE 1126

Query: 574  DNDSYASEIKELQ---LVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQR 630
               ++A E++ LQ     L +  DS     E+L  + +L ++  D   +++++ +   + 
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186

Query: 631  ALLRREFELQSL-SLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGK 689
            +   RE + Q    L+R L +   ++E+  L + +++ +                    K
Sbjct: 1187 SQEGREVQRQEAGELRRSLGE--GAKEREALRRSNEELRSAV-----------------K 1227

Query: 690  VLPSEGDDFLEVNSMKELYL-LMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
               SE       N  KE  L L+EE          +  TG    + +  E  + L +++ 
Sbjct: 1228 KAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRR 1287

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDW 808
             +K L        R L ELQ + A        ERAE +     + L+     GE      
Sbjct: 1288 QMKMLDSENTRLGRELAELQGRLALG------ERAEKESRRETLGLRQRLLKGE------ 1335

Query: 809  KAALQREREEQQHLLAESYSAVMELTRQLQISE---RNWSQEKLQLVERLQGEKQQVEQQ 865
             A+L+  R+E Q              R+LQ  E   R   +  L  +E  +G ++Q    
Sbjct: 1336 -ASLEVMRQELQ-----------VAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383

Query: 866  VKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGG 918
             + L+ +L   +  A    L+ S  E +     E    ++  +   +E +LGG
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQG-LEAELARVEVQRRAAEAQLGG 1435



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 223/989 (22%), Positives = 369/989 (37%), Gaps = 145/989 (14%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK 69
            EED+ +LQ  ++             +R  +AER  L++ Q  +   EL+  LE + +   
Sbjct: 992  EEDLQRLQREKEAA-----------WRELEAERAQLQS-QLQREQEELLARLEAEKEELS 1039

Query: 70   DISMRLHKE------LEVVEKKRARLEEENEE--LRQRLIETELAKQVLQTELERPREHS 121
            +    L +E      L   EK++A   +E+E+  L ++L+ T  +   +  E+ER     
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMER----- 1094

Query: 122  LKKRGTRSLGKADKKTL--VQEDSADLKCQLHFAKEESALMCKKLTK----LAKENDSM- 174
             +KR  +S  + D+ T+  +  +  DL+ Q   A    A   ++L +    L K+ DS  
Sbjct: 1095 -QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL 1153

Query: 175  --KEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVE 232
               EEL     L  D    L  E L      RE++    ++   +EA  L R + E   E
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ--RQEAGELRRSLGEGAKE 1211

Query: 233  NRGLRAEMDDMKDHGGGCGGP-----------EARLAFSALGGGECGESLAELRRHLQFV 281
               LR   ++++                    E +LA         G+   ELR  LQ V
Sbjct: 1212 REALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV 1271

Query: 282  EE-------EAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEE 334
            E        E + LRR    L+ +N  L  ELA+ +    L     ++S        Q  
Sbjct: 1272 ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRL 1331

Query: 335  L---AAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCV 391
            L   A+ ++   EL    +KLQ +     +  +R  L S +  R    T+ +  D A+ +
Sbjct: 1332 LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL-LGSLEEARG---TEKQQLDHARGL 1387

Query: 392  PAPLGETHESHAVRLCRAREAEV-LPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNE 450
               L       A    R   AE    GL  + A V        A   G  + LR  L   
Sbjct: 1388 ELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLG-- 1445

Query: 451  CADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSS 510
                 L  AP  S  PR      A         + LN+      + L CS   Q  S   
Sbjct: 1446 -----LGRAP--SPAPRPVPGSPARDAPAEGSGEGLNS-----PSTLECSPGSQPPSPGP 1493

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD-LDSKPDPSRSFRP 569
                 S  L  E +                L E+   +R A R  D L ++         
Sbjct: 1494 ATSPASPDLDPEAVRGA-------------LREFLQELRSAQRERDELRTQTSALNRQLA 1540

Query: 570  YRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLS--------QERQLRKEEADNFNQKM 621
                + DS  S  ++LQ  +AE+ ++ R +  +LS        QE  +R+ E +   +  
Sbjct: 1541 EMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERER--RAT 1598

Query: 622  VQLKEDQQRALLRREFELQS----LSLQRRLEQKFWSQEKNM--LVQESQQFKHNFLLLF 675
            +      +R+L   E EL++    +S  +  E K    ++ +  ++  S+       L  
Sbjct: 1599 LDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQR 1658

Query: 676  MKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNT 735
              L   L+R R G       D   +  ++++       + +  Q +D++   G      T
Sbjct: 1659 RSLEGELQRSRLGL-----SDREAQAQALQD-----RVDSLQRQVADSEVKAG------T 1702

Query: 736  PNEYIKTLADMKVTLKELCWLLRDERRGLTE-LQQQFAKAKATWETERAELKGHTS---- 790
                ++ L      ++E    LRD+ RGLTE L Q  A   +T +      K  T+    
Sbjct: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762

Query: 791  QMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTR-----QLQISERNWS 845
            +  L+    A  +A  + +       E+ Q L  E   A +EL R     QLQ       
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEV--ADLELQRVEAEGQLQQLREVLR 1820

Query: 846  QEK------LQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
            Q +      L  V++LQ E++ +++++  LQ  L+QL+            LEK   + + 
Sbjct: 1821 QRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRR 1880

Query: 900  T----RSEKIHDKEAVSEVELGGNGLKRT 924
            T      EK+   E    +      L RT
Sbjct: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRT 1909



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 205/1019 (20%), Positives = 390/1019 (38%), Gaps = 214/1019 (21%)

Query: 3    EMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRL--RKAERRSLRAAQTGQVDGELIRG 60
            ++RD  + E     Q+++  LD+A  + R+ +  L  ++ E+++L   Q  +   E +  
Sbjct: 370  QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429

Query: 61   LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLI-ETELAKQVLQTE------ 113
            LE         S+RL ++  +  +    L++   +L Q ++ ++E   Q+  +E      
Sbjct: 430  LE---------SLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480

Query: 114  ------LERPREHSLKKRGTRSLGK----------ADKKTLVQEDSA---------DLKC 148
                  L   R  S  +R +   G+          +D  TL    SA         D++ 
Sbjct: 481  NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540

Query: 149  QLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSR---- 204
            +   +++    + K+L+    E  +++E+L + R      D A+ A E A     R    
Sbjct: 541  RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRD---KTDGAMQAHEDAQREVQRLRSA 597

Query: 205  -------ETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARL 257
                   ++ L   L++ +++A  L +   +L+     LR + D +++         AR+
Sbjct: 598  NELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657

Query: 258  ---------AFSALGG--GECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNEL 306
                         L G      + L E+R  L     + ++L+   AE+ +     L + 
Sbjct: 658  RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE----ALTKA 713

Query: 307  AKFRSEHELDV-------ALSEDSCSVLSEPSQEELAAAKLQIGE-----------LSGK 348
               R E EL +       A  +DS S LS    E LA  KL +             L G+
Sbjct: 714  EAGRVELELSMTKLRAEEASLQDSLSKLS-ALNESLAQDKLDLNRLVAQLEEEKSALQGR 772

Query: 349  VKKLQYENRVLLSNLQRCDLASCQS--TRPMLETDAEAGDSAQ-CVPAPL---------- 395
             ++ + E  V     +R +    +    R  LE      + AQ  +   L          
Sbjct: 773  QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQL 832

Query: 396  ------------GETHESHAVRLCRAREAEVLP-GLREQAALVSK----AIDVLVADANG 438
                        G   E    R    R+ E L    RE+ AL  +    A+ ++ A+  G
Sbjct: 833  QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892

Query: 439  FT---AGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADA 495
             T      RL L+ E  +  L E             +   L +L   +++L A       
Sbjct: 893  RTLSEEATRLRLEKEALEGSLFE-------------VQRQLAQLEARREQLEA------- 932

Query: 496  VLGCSVKEQQESFSSLPPLGSQ--GLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFR 553
                   E Q    +   L  +  GL ++I+  ++  S  +    + L + E   + + R
Sbjct: 933  -------EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLR 985

Query: 554  TGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEE 613
                  + D  R  R   A          +EL+   A+    L+  QE+L    +  KEE
Sbjct: 986  EQRAAHEEDLQRLQREKEA--------AWRELEAERAQLQSQLQREQEELLARLEAEKEE 1037

Query: 614  ADNFNQKMVQLKEDQQRALLRREFE-LQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFL 672
                ++++  L++++   LL  E E  Q+LSL+          EK  L ++    +H+  
Sbjct: 1038 ---LSEEIAALQQERDEGLLLAESEKQQALSLK--------ESEKTALSEKLMGTRHSLA 1086

Query: 673  LLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSM-KELY-LLMEEEEINAQHSDNKACTGDS 730
             + +++    KR  Q +    +  D   VN++  EL  L  + EE  A H+       + 
Sbjct: 1087 TISLEME-RQKRDAQSR----QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQ 1141

Query: 731  WTQ--NTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGH 788
                    +  ++   +++  L+ L       RR L E Q++  +++   E +R E    
Sbjct: 1142 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE---- 1197

Query: 789  TSQMELKTGKGAGE-----RAGPDWKAALQR-------------EREEQQHLLAESYSAV 830
              ++    G+GA E     R+  + ++A+++             ++E++  LL E+ +AV
Sbjct: 1198 AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAV 1257

Query: 831  ----MELTRQLQISERNWSQEKLQLVE------RLQGEKQQVEQQVKELQNRLSQLQKA 879
                 EL   LQ  ER+  + + +L E       L  E  ++ +++ ELQ RL+  ++A
Sbjct: 1258 GKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316



 Score = 37.4 bits (85), Expect = 0.072
 Identities = 81/399 (20%), Positives = 161/399 (40%), Gaps = 58/399 (14%)

Query: 597 RGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQR-ALLRREFELQSLSLQRR---LEQKF 652
           RGL  Q  + R+  +EE  ++ +K+   +E QQR A L +  + + L  ++R   LEQ+ 
Sbjct: 135 RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQL 194

Query: 653 WSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLME 712
             +   +  Q  +  +H+  L    +R   ++ R   +         +VN+M        
Sbjct: 195 LERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASL--------AQVNAML------- 239

Query: 713 EEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDER----------- 761
            E+++   S N+A + D   +   N++ +   +++   +E  W   +E            
Sbjct: 240 REQLDQAGSANQALSED--IRKVTNDWTRCRKELE--HREAAWRREEESFNAYFSNEHSR 295

Query: 762 -----RGLTELQQQFAKAKATWETERAELKGHTSQ---------MELKTGKGAGE---RA 804
                R +   ++  ++ K   E +  +L G  ++         + L TG    E    A
Sbjct: 296 LLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEA 355

Query: 805 GPDWKAALQREREEQ--QHLLAESYSAVMELTRQLQISERNWSQEKLQL-VERLQGEKQQ 861
             + +A LQ + EEQ    +L E   A  ++   L  ++ +    +L L V+RL+ +  +
Sbjct: 356 ALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLE 415

Query: 862 VEQQVKELQNRLSQLQ--KAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGN 919
            +Q  K+L  +L  L+  +  +   L+  + E    + ++     + D E  S V+L G+
Sbjct: 416 KDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSE--SGVQLSGS 473

Query: 920 GLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPA 958
                 S  S+         SP       RG+     P+
Sbjct: 474 ERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPS 512



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 62/301 (20%), Positives = 119/301 (39%), Gaps = 49/301 (16%)

Query: 594  DSLRGLQEQLSQERQLRKEEAD---NFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQ 650
            D +RGL E L+Q         D   +  + +   + D+Q    R +   Q+LS  R+   
Sbjct: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARK--- 1782

Query: 651  KFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL 710
                 + + L ++ Q  +     L ++             + +EG    ++  ++E+   
Sbjct: 1783 -----QSSSLGEQVQTLRGEVADLELQR------------VEAEG----QLQQLREVLRQ 1821

Query: 711  MEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQ 770
             +E E  A ++  K        Q       + LA ++   +E+      ER  L   + +
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV------ERSALRLEKDR 1875

Query: 771  FAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAV 830
             A  +   + ER +L+ H   + L   KG  +R     +  L   + + Q L  E+   V
Sbjct: 1876 VALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL--EAQVVV 1933

Query: 831  MELTR---QLQISERNWSQEKLQLVERLQGEKQQVE-----------QQVKELQNRLSQL 876
            +E +    QL++  +    E  Q VERL+  + Q E           Q+V+ L+ ++S L
Sbjct: 1934 LEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL 1993

Query: 877  Q 877
            +
Sbjct: 1994 K 1994



 Score = 34.3 bits (77), Expect = 0.61
 Identities = 51/210 (24%), Positives = 88/210 (41%), Gaps = 21/210 (10%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL 61
            LE++ V  E  + QL+E+ +Q  +          +L+  ERR L+        G L R L
Sbjct: 1801 LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD-ERRLLQERL-----GSLQRAL 1854

Query: 62   EQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHS 121
             Q           L  E   VE+   RLE++   LR+ L + E  ++ L++  +  R  +
Sbjct: 1855 AQ-----------LEAEKREVERSALRLEKDRVALRRTLDKVE--REKLRSHEDTVRLSA 1901

Query: 122  LKKRGTRSLGKADKKTL-VQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK 180
             K R  R+L  A+ +    Q     L+ Q+    E+S    +      ++   +++E+ +
Sbjct: 1902 EKGRLDRTLTGAELELAEAQRQIQQLEAQV-VVLEQSHSPAQLEVDAQQQQLELQQEVER 1960

Query: 181  YRSLYGDLDSALSAEELADAPHSRETELKV 210
             RS     +  L A E A     R  E +V
Sbjct: 1961 LRSAQAQTERTLEARERAHRQRVRGLEEQV 1990



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 34/150 (22%), Positives = 68/150 (45%), Gaps = 7/150 (4%)

Query: 779 ETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMEL-TRQL 837
           E+ER  L+    ++  KT      +A  D +  +QR R   + L  E  +    L   Q 
Sbjct: 560 ESERRALEEQLQRLRDKTD--GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQ 617

Query: 838 QISERNWSQEKLQLV-ERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNS 896
           Q  E    +EKLQ   E L+ ++ ++E++ ++     +++++  +     H +LE+ +  
Sbjct: 618 QAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER---SHRQLEQLEGK 674

Query: 897 WKETRSEKIHDKEAVSEVELGGNGLKRTKS 926
                 E +  +EA+S   L  + L+  K+
Sbjct: 675 RSVLAKELVEVREALSRATLQRDMLQAEKA 704



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 24/85 (28%), Positives = 44/85 (51%), Gaps = 14/85 (16%)

Query: 815 EREEQQHLLAESYSAVMELTRQLQISERNW----------SQEKLQLVERLQGEKQQVEQ 864
           E +E + L+ +S    +EL RQLQ  + ++           Q + QLV+RLQG+  Q ++
Sbjct: 130 ETQEPRGLVRQS----VELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKK 185

Query: 865 QVKELQNRLSQLQKAADPWVLKHSE 889
           +  EL+ +L +     +   L+ +E
Sbjct: 186 RCSELEQQLLERSGELEQQRLRDTE 210


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 207/970 (21%), Positives = 377/970 (38%), Gaps = 113/970 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLR-------KAERRSLRAAQTGQVDGELIRGLEQDVKV 67
            +L+EL Q+  Q ++   +LQ +L+       +AE   +R A   Q   E++  +E  ++ 
Sbjct: 874  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 933

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGT 127
             +D   +L  E + + ++   LEE+ EE      + +L K   + ++++  +  L     
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993

Query: 128  RSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM------------- 174
             +    ++K L++E  +DL   L  A+EE     K LTKL  +++SM             
Sbjct: 994  NNKLSKERK-LLEERISDLTTNL--AEEEEK--AKNLTKLKNKHESMISELEVRLKKEEK 1048

Query: 175  -KEELLKY-RSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANL-LSRRIVELEV 231
             ++EL K  R L GD       E++AD   ++  ELK+ L   EEE    L+R   E+  
Sbjct: 1049 SRQELEKLKRKLEGDASDF--HEQIADL-QAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105

Query: 232  ENRGLRAEMD---DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELL 288
            +N  L+   +    + D         A    +     + GE L  L+  L+   +     
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165

Query: 289  RRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGK 348
            +   A+ E +  +L   L +    HE  V       +   E   E+L   K     L   
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225

Query: 349  VKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD-SAQCVPAPLGETHESHAVRLC 407
             + L+ EN  L   L+    A  +      + +A+  +  ++C          +  V   
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285

Query: 408  RAREAEVLPGLREQAALVSKAIDVL--VADANGFTAGLRLCLDNECADFRLHEAPDNSEG 465
            +  E E + G+  +A    KAI +   VA  +      +  L  E    +L+ +    + 
Sbjct: 1286 Q-NEVESVTGMLNEAE--GKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQL 1341

Query: 466  PRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL--GSQGLSKEI 523
              +   +   L      +Q L       +  L  S K+ Q+  S++  L  G +   KEI
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401

Query: 524  LLAKDLGSDFQ--PPDFRDLPEWEPRIREAF--RTGDLDSK-------PDPSRSFRPYRA 572
               ++L   ++     +  L + + R+++       DLD++           R F    A
Sbjct: 1402 ---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458

Query: 573  EDN-------------DSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQ 619
            E+              ++ A E +   L LA A +     +E+L +  ++ K E ++   
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED--- 1515

Query: 620  KMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLR 679
             +V  K+D  + +   E   ++L  Q   E K   +E    +Q ++  K    +    L+
Sbjct: 1516 -LVSSKDDVGKNVHELEKSKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQALK 1573

Query: 680  WFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEE--EINAQHSDNKACTGD-------- 729
               +R  Q +   +E         + E    +E+E  +     +  K   GD        
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633

Query: 730  SWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHT 789
                    E IK L  ++  +K+    L D R    E+   FA AK   E E+       
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAK---ENEKKAKSLEA 1687

Query: 790  SQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKL 849
              M+L+    A ERA        +++ + ++  LAE  ++ +     LQ  +R       
Sbjct: 1688 DLMQLQEDLAAAERA--------RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 850  QLVERLQGEKQQVE----------QQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
            QL E L+ E+  +E          QQ ++L N L+  +  A        +LE+Q+   KE
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN---KE 1796

Query: 900  TRSEKIHDKE 909
             RS K+H+ E
Sbjct: 1797 LRS-KLHEME 1805



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/987 (20%), Positives = 409/987 (41%), Gaps = 141/987 (14%)

Query: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGEL-IR 59
            +L   +  +EE+  + Q+L+ +  + ++    L+ +L + E  + +  Q  +V  E  I+
Sbjct: 923  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIK 981

Query: 60   GLEQDVKVSKDISMRLHKELEVVEKKRARLEE---ENEELRQRLIETELAKQVLQTELER 116
             LE ++ V  D + +L KE +++E++ + L     E EE  + L + +   + + +ELE 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041

Query: 117  PREHSLKKRGTRSLGKADKKTL------------VQEDSADLKCQLHFAKEE-SALMCKK 163
              +   K R  + L K  +K              +Q   A+LK QL   +EE  A + + 
Sbjct: 1042 RLKKEEKSR--QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 164  LTKLAKENDSMKE--ELLKYRS-LYGDLDSALSAE--------ELADAPHSRETELKVHL 212
              ++A++N+++K+  EL  + S L  DLDS  +A         +L +   + +TEL+  L
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159

Query: 213  KLVEEEANLLSRRIVELEV-------ENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG 265
                 +  L ++R  E+ V       E R   A++ +M+                A    
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK-------------HAQAVE 1206

Query: 266  ECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCS 325
            E  E L + +R    +++  + L + +A+L  + ++L    AK   EH+    L      
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AKQEVEHKKK-KLEAQVQE 1263

Query: 326  VLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAG 385
            + S+ S  E A A     EL+ KV KLQ E   +   L   +  + +  + +    ++  
Sbjct: 1264 LQSKCSDGERARA-----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 386  DSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRL 445
            D+ + +     ET +   V   + R+ E      E+ +L  +  + + A  N        
Sbjct: 1319 DTQELLQE---ETRQKLNVST-KLRQLE-----EERNSLQDQLDEEMEAKQN-------- 1361

Query: 446  CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKA-------DAVLG 498
             L+   +   +  +    +       + A+       Q+E+   T++        D +  
Sbjct: 1362 -LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 499  CSVKEQQESFSSLPPLGSQ-----GLSK-----EILLAKDLGSDFQPPDFRDLPEWEPRI 548
               + QQE    +  L +Q      L K     + LLA++     +  D RD  E E R 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 549  REAFRTG-------DLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQE 601
            +E             L++K +  R+ +  +AE  D  +S+  ++   + E   S R L+ 
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALET 1539

Query: 602  QLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLV 661
            Q+ + +   +E  D      +Q  ED   A LR E  +Q+L  Q   + +   ++     
Sbjct: 1540 QMEEMKTQLEELEDE-----LQATED---AKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591

Query: 662  QESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHS 721
            ++ Q+  H +          L+  R+ + L +     LE   +K+L L  +    +A   
Sbjct: 1592 RQLQRQLHEY-------ETELEDERKQRALAAAAKKKLE-GDLKDLELQAD----SAIKG 1639

Query: 722  DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERR-------GLTELQQQFAKA 774
              +A       Q    ++ + L D + +  E+    ++  +        L +LQ+  A A
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWK-------AALQREREEQQHLLAESY 827
            +     ++A+L+      EL +   +G  A  D K       A L+ E EE+Q  +    
Sbjct: 1700 ERA--RKQADLEKEELAEELASSL-SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 828  SAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAA-DPWVLK 886
              V + T+Q +      + E+    ++ +  +QQ+E+Q KEL+++L +++ A    +   
Sbjct: 1757 DRVRKATQQAEQLSNELATER-STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815

Query: 887  HSELEKQDNSWKETRSEKIHDKEAVSE 913
             + LE +    +E   ++  +K+A ++
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATK 1842



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 62/255 (24%), Positives = 102/255 (40%), Gaps = 29/255 (11%)

Query: 17   QELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLH 76
            +EL ++L  +      LQ   R+ E R  +  +  + +   +  +   V+ +   + +L 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 77   KELEVV-------EKKRARLEEENEELRQRLIETE-------------LAKQVLQTELER 116
             EL          E  R +LE +N+ELR +L E E             L  ++ Q E + 
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830

Query: 117  PREHSLKKRGTRSLGKADKK----TLVQEDSADLKCQLHFAKEESALMCKKLTKLAKEND 172
             +E   K+  T+SL + DKK     L  ED   +  Q     E+     K+L +  +E +
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890

Query: 173  SMKEEL-LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEV 231
               + +    R L  +LD A  + E   A       LK  L+   E + + SRR     V
Sbjct: 1891 EESQRINANRRKLQRELDEATESNE---AMGREVNALKSKLRRGNETSFVPSRRSGGRRV 1947

Query: 232  -ENRGLRAEMDDMKD 245
             EN     E  D +D
Sbjct: 1948 IENADGSEEETDTRD 1962



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 92/390 (23%), Positives = 160/390 (41%), Gaps = 83/390 (21%)

Query: 600  QEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFEL-------QSLSLQRRLEQKF 652
            Q+ L  E QL +EEA    QK+   K   +  + + E E+         LS +R+L ++ 
Sbjct: 950  QQMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007

Query: 653  WSQEKNMLVQESQQFK--------HNFLLLFMKLRWFLKRWRQGKV--------LPSEGD 696
             S     L +E ++ K        H  ++  +++R  LK+  + +         L  +  
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDAS 1065

Query: 697  DFLE--------VNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            DF E        +  +K + L  +EEE+ A      A   D   Q   N  +K + +++ 
Sbjct: 1066 DFHEQIADLQAQIAELK-MQLAKKEEELQAA----LARLDDEIAQK--NNALKKIRELEG 1118

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETERAELK----GHTSQMELKTGKGAGERA 804
             + +L   L  ER    + ++Q        E  + EL+       +Q EL+  +   E+ 
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR---EQE 1175

Query: 805  GPDWKAALQREREEQ----QHLLAESYSAVMELTRQLQISER---NWSQEKLQLVER--- 854
                K AL  E        Q +  +   AV ELT QL+  +R   N  + K  L +    
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235

Query: 855  LQGE-------KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH- 906
            L GE       KQ+VE + K+L+ ++ +LQ          +EL           ++K+H 
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-----------NDKVHK 1284

Query: 907  ---DKEAVSEV--ELGGNGLKRTKSVSSMS 931
               + E+V+ +  E  G  +K  K V+S+S
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 71/314 (22%), Positives = 132/314 (42%), Gaps = 23/314 (7%)

Query: 585  LQLVLAEAHDSLRGLQEQLSQERQLRKE-EADNFNQKMVQLKEDQQ--RALLRREFELQS 641
            LQ+   E     +  + Q ++ERQ + E E     QK  QL E++   +  L+ E EL +
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 642  LSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEV 701
             + + R+      QE   ++ E            M+ R   +  R G+ L +E     + 
Sbjct: 905  EAEEMRVRLAAKKQELEEILHE------------MEARLEEEEDR-GQQLQAERKKMAQ- 950

Query: 702  NSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDER 761
              M +L   +EEEE   Q    +  T ++  +   +E I  + D    L +   LL +  
Sbjct: 951  -QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERI 1008

Query: 762  RGLT-ELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD-WKAALQREREEQ 819
              LT  L ++  KAK   + +    +   S++E++  K    R   +  K  L+ +  + 
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 820  QHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKA 879
               +A+  + + EL  QL   E        +L + +  +K    ++++EL+  +S LQ+ 
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI-AQKNNALKKIRELEGHISDLQED 1126

Query: 880  ADPWVLKHSELEKQ 893
             D      ++ EKQ
Sbjct: 1127 LDSERAARNKAEKQ 1140



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 75/341 (21%), Positives = 143/341 (41%), Gaps = 55/341 (16%)

Query: 580  SEIKELQLVLAEAHDSLRGLQEQLSQERQL-------------RKEEADNFNQKM-VQLK 625
            +E+KEL+   ++  +    LQEQL  E +L             +K+E +    +M  +L+
Sbjct: 873  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932

Query: 626  ED----QQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFL---LLFM-- 676
            E+    QQ    R++   Q L L+ +LE++  +++K  L + + + K   L   +L M  
Sbjct: 933  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992

Query: 677  ------KLRWFLKRWRQGKV--LPSEGDDFLEVNSMK--------ELYLLMEEEEINAQH 720
                  K R  L+         L  E +    +  +K        EL + +++EE + Q 
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052

Query: 721  SD--NKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLL----RDERRGLTELQQQFAKA 774
             +   +   GD+      +++ + +AD++  + EL   L     + +  L  L  + A+ 
Sbjct: 1053 LEKLKRKLEGDA------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELT 834
                +  R EL+GH S ++        ERA  +     +R+  E+   L       ++ T
Sbjct: 1107 NNALKKIR-ELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162

Query: 835  RQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQ 875
               Q       QE   L + L  E +  E QV+E++ + +Q
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 31/147 (21%), Positives = 70/147 (47%), Gaps = 2/147 (1%)

Query: 771 FAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQRERE--EQQHLLAESYS 828
           F K K   +  R E +    + EL+  K   ++A  + K   Q+  +  E+++LL E   
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897

Query: 829 AVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHS 888
           A  EL  + +      + +K +L E L   + ++E++    Q   ++ +K A   +    
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 889 ELEKQDNSWKETRSEKIHDKEAVSEVE 915
           +LE+++ + ++ + EK+  +  + ++E
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLE 984



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 81/378 (21%), Positives = 145/378 (38%), Gaps = 42/378 (11%)

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKE------- 626
            D   +  +I +LQ  +AE    L   +E+L        +E    N  + +++E       
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122

Query: 627  -----DQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
                 D +RA  R + E Q   L   LE      E  +    +QQ          +LR  
Sbjct: 1123 LQEDLDSERA-ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----------ELR-- 1169

Query: 682  LKRWRQGKVLPSEGDD-----FLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTP 736
             KR ++  VL    D+       +V  M++ +    EE         +A       + T 
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229

Query: 737  NEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAEL--KGHTSQMEL 794
             +    LA     L +    +  +++ L    Q+     +  E  RAEL  K H  Q E+
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 795  KTGKG-AGERAGPDWK-----AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEK 848
            ++  G   E  G   K     A+L  + ++ Q LL E     + ++ +L+  E   +  +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 849  LQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDK 908
             QL E ++  KQ +E+ +  L  +LS  +K    +    S +E  +   K  + E  +  
Sbjct: 1350 DQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFA---STVEALEEGKKRFQKEIENLT 1405

Query: 909  EAVSEVELGGNGLKRTKS 926
            +   E     + L++TK+
Sbjct: 1406 QQYEEKAAAYDKLEKTKN 1423


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 207/970 (21%), Positives = 377/970 (38%), Gaps = 113/970 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLR-------KAERRSLRAAQTGQVDGELIRGLEQDVKV 67
            +L+EL Q+  Q ++   +LQ +L+       +AE   +R A   Q   E++  +E  ++ 
Sbjct: 881  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 940

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGT 127
             +D   +L  E + + ++   LEE+ EE      + +L K   + ++++  +  L     
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000

Query: 128  RSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM------------- 174
             +    ++K L++E  +DL   L  A+EE     K LTKL  +++SM             
Sbjct: 1001 NNKLSKERK-LLEERISDLTTNL--AEEEEK--AKNLTKLKNKHESMISELEVRLKKEEK 1055

Query: 175  -KEELLKY-RSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANL-LSRRIVELEV 231
             ++EL K  R L GD       E++AD   ++  ELK+ L   EEE    L+R   E+  
Sbjct: 1056 SRQELEKLKRKLEGDASDF--HEQIADL-QAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112

Query: 232  ENRGLRAEMD---DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELL 288
            +N  L+   +    + D         A    +     + GE L  L+  L+   +     
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

Query: 289  RRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGK 348
            +   A+ E +  +L   L +    HE  V       +   E   E+L   K     L   
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 349  VKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD-SAQCVPAPLGETHESHAVRLC 407
             + L+ EN  L   L+    A  +      + +A+  +  ++C          +  V   
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292

Query: 408  RAREAEVLPGLREQAALVSKAIDVL--VADANGFTAGLRLCLDNECADFRLHEAPDNSEG 465
            +  E E + G+  +A    KAI +   VA  +      +  L  E    +L+ +    + 
Sbjct: 1293 Q-NEVESVTGMLNEAE--GKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQL 1348

Query: 466  PRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL--GSQGLSKEI 523
              +   +   L      +Q L       +  L  S K+ Q+  S++  L  G +   KEI
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408

Query: 524  LLAKDLGSDFQ--PPDFRDLPEWEPRIREAF--RTGDLDSK-------PDPSRSFRPYRA 572
               ++L   ++     +  L + + R+++       DLD++           R F    A
Sbjct: 1409 ---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465

Query: 573  EDN-------------DSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQ 619
            E+              ++ A E +   L LA A +     +E+L +  ++ K E ++   
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED--- 1522

Query: 620  KMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLR 679
             +V  K+D  + +   E   ++L  Q   E K   +E    +Q ++  K    +    L+
Sbjct: 1523 -LVSSKDDVGKNVHELEKSKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQALK 1580

Query: 680  WFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEE--EINAQHSDNKACTGD-------- 729
               +R  Q +   +E         + E    +E+E  +     +  K   GD        
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640

Query: 730  SWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHT 789
                    E IK L  ++  +K+    L D R    E+   FA AK   E E+       
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAK---ENEKKAKSLEA 1694

Query: 790  SQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKL 849
              M+L+    A ERA        +++ + ++  LAE  ++ +     LQ  +R       
Sbjct: 1695 DLMQLQEDLAAAERA--------RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 850  QLVERLQGEKQQVE----------QQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
            QL E L+ E+  +E          QQ ++L N L+  +  A        +LE+Q+   KE
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN---KE 1803

Query: 900  TRSEKIHDKE 909
             RS K+H+ E
Sbjct: 1804 LRS-KLHEME 1812



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/987 (20%), Positives = 409/987 (41%), Gaps = 141/987 (14%)

Query: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGEL-IR 59
            +L   +  +EE+  + Q+L+ +  + ++    L+ +L + E  + +  Q  +V  E  I+
Sbjct: 930  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIK 988

Query: 60   GLEQDVKVSKDISMRLHKELEVVEKKRARLEE---ENEELRQRLIETELAKQVLQTELER 116
             LE ++ V  D + +L KE +++E++ + L     E EE  + L + +   + + +ELE 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048

Query: 117  PREHSLKKRGTRSLGKADKKTL------------VQEDSADLKCQLHFAKEE-SALMCKK 163
              +   K R  + L K  +K              +Q   A+LK QL   +EE  A + + 
Sbjct: 1049 RLKKEEKSR--QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 164  LTKLAKENDSMKE--ELLKYRS-LYGDLDSALSAE--------ELADAPHSRETELKVHL 212
              ++A++N+++K+  EL  + S L  DLDS  +A         +L +   + +TEL+  L
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166

Query: 213  KLVEEEANLLSRRIVELEV-------ENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG 265
                 +  L ++R  E+ V       E R   A++ +M+                A    
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK-------------HAQAVE 1213

Query: 266  ECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCS 325
            E  E L + +R    +++  + L + +A+L  + ++L    AK   EH+    L      
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AKQEVEHKKK-KLEAQVQE 1270

Query: 326  VLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAG 385
            + S+ S  E A A     EL+ KV KLQ E   +   L   +  + +  + +    ++  
Sbjct: 1271 LQSKCSDGERARA-----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 386  DSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRL 445
            D+ + +     ET +   V   + R+ E      E+ +L  +  + + A  N        
Sbjct: 1326 DTQELLQE---ETRQKLNVST-KLRQLE-----EERNSLQDQLDEEMEAKQN-------- 1368

Query: 446  CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKA-------DAVLG 498
             L+   +   +  +    +       + A+       Q+E+   T++        D +  
Sbjct: 1369 -LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 499  CSVKEQQESFSSLPPLGSQ-----GLSK-----EILLAKDLGSDFQPPDFRDLPEWEPRI 548
               + QQE    +  L +Q      L K     + LLA++     +  D RD  E E R 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 549  REAFRTG-------DLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQE 601
            +E             L++K +  R+ +  +AE  D  +S+  ++   + E   S R L+ 
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALET 1546

Query: 602  QLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLV 661
            Q+ + +   +E  D      +Q  ED   A LR E  +Q+L  Q   + +   ++     
Sbjct: 1547 QMEEMKTQLEELEDE-----LQATED---AKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598

Query: 662  QESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHS 721
            ++ Q+  H +          L+  R+ + L +     LE   +K+L L  +    +A   
Sbjct: 1599 RQLQRQLHEY-------ETELEDERKQRALAAAAKKKLE-GDLKDLELQAD----SAIKG 1646

Query: 722  DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERR-------GLTELQQQFAKA 774
              +A       Q    ++ + L D + +  E+    ++  +        L +LQ+  A A
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWK-------AALQREREEQQHLLAESY 827
            +     ++A+L+      EL +   +G  A  D K       A L+ E EE+Q  +    
Sbjct: 1707 ERA--RKQADLEKEELAEELASSL-SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 828  SAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAA-DPWVLK 886
              V + T+Q +      + E+    ++ +  +QQ+E+Q KEL+++L +++ A    +   
Sbjct: 1764 DRVRKATQQAEQLSNELATER-STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822

Query: 887  HSELEKQDNSWKETRSEKIHDKEAVSE 913
             + LE +    +E   ++  +K+A ++
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATK 1849



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 62/255 (24%), Positives = 102/255 (40%), Gaps = 29/255 (11%)

Query: 17   QELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLH 76
            +EL ++L  +      LQ   R+ E R  +  +  + +   +  +   V+ +   + +L 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 77   KELEVV-------EKKRARLEEENEELRQRLIETE-------------LAKQVLQTELER 116
             EL          E  R +LE +N+ELR +L E E             L  ++ Q E + 
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837

Query: 117  PREHSLKKRGTRSLGKADKK----TLVQEDSADLKCQLHFAKEESALMCKKLTKLAKEND 172
             +E   K+  T+SL + DKK     L  ED   +  Q     E+     K+L +  +E +
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897

Query: 173  SMKEEL-LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEV 231
               + +    R L  +LD A  + E   A       LK  L+   E + + SRR     V
Sbjct: 1898 EESQRINANRRKLQRELDEATESNE---AMGREVNALKSKLRRGNETSFVPSRRSGGRRV 1954

Query: 232  -ENRGLRAEMDDMKD 245
             EN     E  D +D
Sbjct: 1955 IENADGSEEETDTRD 1969



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 92/390 (23%), Positives = 160/390 (41%), Gaps = 83/390 (21%)

Query: 600  QEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFEL-------QSLSLQRRLEQKF 652
            Q+ L  E QL +EEA    QK+   K   +  + + E E+         LS +R+L ++ 
Sbjct: 957  QQMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014

Query: 653  WSQEKNMLVQESQQFK--------HNFLLLFMKLRWFLKRWRQGKV--------LPSEGD 696
             S     L +E ++ K        H  ++  +++R  LK+  + +         L  +  
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDAS 1072

Query: 697  DFLE--------VNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            DF E        +  +K + L  +EEE+ A      A   D   Q   N  +K + +++ 
Sbjct: 1073 DFHEQIADLQAQIAELK-MQLAKKEEELQAA----LARLDDEIAQK--NNALKKIRELEG 1125

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETERAELK----GHTSQMELKTGKGAGERA 804
             + +L   L  ER    + ++Q        E  + EL+       +Q EL+  +   E+ 
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR---EQE 1182

Query: 805  GPDWKAALQREREEQ----QHLLAESYSAVMELTRQLQISER---NWSQEKLQLVER--- 854
                K AL  E        Q +  +   AV ELT QL+  +R   N  + K  L +    
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242

Query: 855  LQGE-------KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH- 906
            L GE       KQ+VE + K+L+ ++ +LQ          +EL           ++K+H 
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-----------NDKVHK 1291

Query: 907  ---DKEAVSEV--ELGGNGLKRTKSVSSMS 931
               + E+V+ +  E  G  +K  K V+S+S
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 71/314 (22%), Positives = 132/314 (42%), Gaps = 23/314 (7%)

Query: 585  LQLVLAEAHDSLRGLQEQLSQERQLRKE-EADNFNQKMVQLKEDQQ--RALLRREFELQS 641
            LQ+   E     +  + Q ++ERQ + E E     QK  QL E++   +  L+ E EL +
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 642  LSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEV 701
             + + R+      QE   ++ E            M+ R   +  R G+ L +E     + 
Sbjct: 912  EAEEMRVRLAAKKQELEEILHE------------MEARLEEEEDR-GQQLQAERKKMAQ- 957

Query: 702  NSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDER 761
              M +L   +EEEE   Q    +  T ++  +   +E I  + D    L +   LL +  
Sbjct: 958  -QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERI 1015

Query: 762  RGLT-ELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD-WKAALQREREEQ 819
              LT  L ++  KAK   + +    +   S++E++  K    R   +  K  L+ +  + 
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 820  QHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKA 879
               +A+  + + EL  QL   E        +L + +  +K    ++++EL+  +S LQ+ 
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI-AQKNNALKKIRELEGHISDLQED 1133

Query: 880  ADPWVLKHSELEKQ 893
             D      ++ EKQ
Sbjct: 1134 LDSERAARNKAEKQ 1147



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 75/341 (21%), Positives = 143/341 (41%), Gaps = 55/341 (16%)

Query: 580  SEIKELQLVLAEAHDSLRGLQEQLSQERQL-------------RKEEADNFNQKM-VQLK 625
            +E+KEL+   ++  +    LQEQL  E +L             +K+E +    +M  +L+
Sbjct: 880  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939

Query: 626  ED----QQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFL---LLFM-- 676
            E+    QQ    R++   Q L L+ +LE++  +++K  L + + + K   L   +L M  
Sbjct: 940  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999

Query: 677  ------KLRWFLKRWRQGKV--LPSEGDDFLEVNSMK--------ELYLLMEEEEINAQH 720
                  K R  L+         L  E +    +  +K        EL + +++EE + Q 
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059

Query: 721  SD--NKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLL----RDERRGLTELQQQFAKA 774
             +   +   GD+      +++ + +AD++  + EL   L     + +  L  L  + A+ 
Sbjct: 1060 LEKLKRKLEGDA------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELT 834
                +  R EL+GH S ++        ERA  +     +R+  E+   L       ++ T
Sbjct: 1114 NNALKKIR-ELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169

Query: 835  RQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQ 875
               Q       QE   L + L  E +  E QV+E++ + +Q
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 31/147 (21%), Positives = 70/147 (47%), Gaps = 2/147 (1%)

Query: 771 FAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQRERE--EQQHLLAESYS 828
           F K K   +  R E +    + EL+  K   ++A  + K   Q+  +  E+++LL E   
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904

Query: 829 AVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHS 888
           A  EL  + +      + +K +L E L   + ++E++    Q   ++ +K A   +    
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 889 ELEKQDNSWKETRSEKIHDKEAVSEVE 915
           +LE+++ + ++ + EK+  +  + ++E
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLE 991



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 81/378 (21%), Positives = 145/378 (38%), Gaps = 42/378 (11%)

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKE------- 626
            D   +  +I +LQ  +AE    L   +E+L        +E    N  + +++E       
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129

Query: 627  -----DQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
                 D +RA  R + E Q   L   LE      E  +    +QQ          +LR  
Sbjct: 1130 LQEDLDSERA-ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----------ELR-- 1176

Query: 682  LKRWRQGKVLPSEGDD-----FLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTP 736
             KR ++  VL    D+       +V  M++ +    EE         +A       + T 
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236

Query: 737  NEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAEL--KGHTSQMEL 794
             +    LA     L +    +  +++ L    Q+     +  E  RAEL  K H  Q E+
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 795  KTGKG-AGERAGPDWK-----AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEK 848
            ++  G   E  G   K     A+L  + ++ Q LL E     + ++ +L+  E   +  +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 849  LQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDK 908
             QL E ++  KQ +E+ +  L  +LS  +K    +    S +E  +   K  + E  +  
Sbjct: 1357 DQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFA---STVEALEEGKKRFQKEIENLT 1412

Query: 909  EAVSEVELGGNGLKRTKS 926
            +   E     + L++TK+
Sbjct: 1413 QQYEEKAAAYDKLEKTKN 1430


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 207/970 (21%), Positives = 377/970 (38%), Gaps = 113/970 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLR-------KAERRSLRAAQTGQVDGELIRGLEQDVKV 67
            +L+EL Q+  Q ++   +LQ +L+       +AE   +R A   Q   E++  +E  ++ 
Sbjct: 881  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 940

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGT 127
             +D   +L  E + + ++   LEE+ EE      + +L K   + ++++  +  L     
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000

Query: 128  RSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM------------- 174
             +    ++K L++E  +DL   L  A+EE     K LTKL  +++SM             
Sbjct: 1001 NNKLSKERK-LLEERISDLTTNL--AEEEEK--AKNLTKLKNKHESMISELEVRLKKEEK 1055

Query: 175  -KEELLKY-RSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANL-LSRRIVELEV 231
             ++EL K  R L GD       E++AD   ++  ELK+ L   EEE    L+R   E+  
Sbjct: 1056 SRQELEKLKRKLEGDASDF--HEQIADL-QAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112

Query: 232  ENRGLRAEMD---DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELL 288
            +N  L+   +    + D         A    +     + GE L  L+  L+   +     
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

Query: 289  RRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGK 348
            +   A+ E +  +L   L +    HE  V       +   E   E+L   K     L   
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 349  VKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD-SAQCVPAPLGETHESHAVRLC 407
             + L+ EN  L   L+    A  +      + +A+  +  ++C          +  V   
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292

Query: 408  RAREAEVLPGLREQAALVSKAIDVL--VADANGFTAGLRLCLDNECADFRLHEAPDNSEG 465
            +  E E + G+  +A    KAI +   VA  +      +  L  E    +L+ +    + 
Sbjct: 1293 Q-NEVESVTGMLNEAE--GKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQL 1348

Query: 466  PRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL--GSQGLSKEI 523
              +   +   L      +Q L       +  L  S K+ Q+  S++  L  G +   KEI
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408

Query: 524  LLAKDLGSDFQ--PPDFRDLPEWEPRIREAF--RTGDLDSK-------PDPSRSFRPYRA 572
               ++L   ++     +  L + + R+++       DLD++           R F    A
Sbjct: 1409 ---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465

Query: 573  EDN-------------DSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQ 619
            E+              ++ A E +   L LA A +     +E+L +  ++ K E ++   
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED--- 1522

Query: 620  KMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLR 679
             +V  K+D  + +   E   ++L  Q   E K   +E    +Q ++  K    +    L+
Sbjct: 1523 -LVSSKDDVGKNVHELEKSKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQALK 1580

Query: 680  WFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEE--EINAQHSDNKACTGD-------- 729
               +R  Q +   +E         + E    +E+E  +     +  K   GD        
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640

Query: 730  SWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHT 789
                    E IK L  ++  +K+    L D R    E+   FA AK   E E+       
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAK---ENEKKAKSLEA 1694

Query: 790  SQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKL 849
              M+L+    A ERA        +++ + ++  LAE  ++ +     LQ  +R       
Sbjct: 1695 DLMQLQEDLAAAERA--------RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 850  QLVERLQGEKQQVE----------QQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
            QL E L+ E+  +E          QQ ++L N L+  +  A        +LE+Q+   KE
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN---KE 1803

Query: 900  TRSEKIHDKE 909
             RS K+H+ E
Sbjct: 1804 LRS-KLHEME 1812



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/987 (20%), Positives = 409/987 (41%), Gaps = 141/987 (14%)

Query: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGEL-IR 59
            +L   +  +EE+  + Q+L+ +  + ++    L+ +L + E  + +  Q  +V  E  I+
Sbjct: 930  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIK 988

Query: 60   GLEQDVKVSKDISMRLHKELEVVEKKRARLEE---ENEELRQRLIETELAKQVLQTELER 116
             LE ++ V  D + +L KE +++E++ + L     E EE  + L + +   + + +ELE 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048

Query: 117  PREHSLKKRGTRSLGKADKKTL------------VQEDSADLKCQLHFAKEE-SALMCKK 163
              +   K R  + L K  +K              +Q   A+LK QL   +EE  A + + 
Sbjct: 1049 RLKKEEKSR--QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 164  LTKLAKENDSMKE--ELLKYRS-LYGDLDSALSAE--------ELADAPHSRETELKVHL 212
              ++A++N+++K+  EL  + S L  DLDS  +A         +L +   + +TEL+  L
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166

Query: 213  KLVEEEANLLSRRIVELEV-------ENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG 265
                 +  L ++R  E+ V       E R   A++ +M+                A    
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK-------------HAQAVE 1213

Query: 266  ECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCS 325
            E  E L + +R    +++  + L + +A+L  + ++L    AK   EH+    L      
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AKQEVEHKKK-KLEAQVQE 1270

Query: 326  VLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAG 385
            + S+ S  E A A     EL+ KV KLQ E   +   L   +  + +  + +    ++  
Sbjct: 1271 LQSKCSDGERARA-----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 386  DSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRL 445
            D+ + +     ET +   V   + R+ E      E+ +L  +  + + A  N        
Sbjct: 1326 DTQELLQE---ETRQKLNVST-KLRQLE-----EERNSLQDQLDEEMEAKQN-------- 1368

Query: 446  CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKA-------DAVLG 498
             L+   +   +  +    +       + A+       Q+E+   T++        D +  
Sbjct: 1369 -LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 499  CSVKEQQESFSSLPPLGSQ-----GLSK-----EILLAKDLGSDFQPPDFRDLPEWEPRI 548
               + QQE    +  L +Q      L K     + LLA++     +  D RD  E E R 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 549  REAFRTG-------DLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQE 601
            +E             L++K +  R+ +  +AE  D  +S+  ++   + E   S R L+ 
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALET 1546

Query: 602  QLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLV 661
            Q+ + +   +E  D      +Q  ED   A LR E  +Q+L  Q   + +   ++     
Sbjct: 1547 QMEEMKTQLEELEDE-----LQATED---AKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598

Query: 662  QESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHS 721
            ++ Q+  H +          L+  R+ + L +     LE   +K+L L  +    +A   
Sbjct: 1599 RQLQRQLHEY-------ETELEDERKQRALAAAAKKKLE-GDLKDLELQAD----SAIKG 1646

Query: 722  DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERR-------GLTELQQQFAKA 774
              +A       Q    ++ + L D + +  E+    ++  +        L +LQ+  A A
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWK-------AALQREREEQQHLLAESY 827
            +     ++A+L+      EL +   +G  A  D K       A L+ E EE+Q  +    
Sbjct: 1707 ERA--RKQADLEKEELAEELASSL-SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 828  SAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAA-DPWVLK 886
              V + T+Q +      + E+    ++ +  +QQ+E+Q KEL+++L +++ A    +   
Sbjct: 1764 DRVRKATQQAEQLSNELATER-STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822

Query: 887  HSELEKQDNSWKETRSEKIHDKEAVSE 913
             + LE +    +E   ++  +K+A ++
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATK 1849



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 48/205 (23%), Positives = 84/205 (40%), Gaps = 25/205 (12%)

Query: 17   QELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLH 76
            +EL ++L  +      LQ   R+ E R  +  +  + +   +  +   V+ +   + +L 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 77   KELEVV-------EKKRARLEEENEELRQRLIETE-------------LAKQVLQTELER 116
             EL          E  R +LE +N+ELR +L E E             L  ++ Q E + 
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837

Query: 117  PREHSLKKRGTRSLGKADKK----TLVQEDSADLKCQLHFAKEESALMCKKLTKLAKEND 172
             +E   K+  T+SL + DKK     L  ED   +  Q     E+     K+L +  +E +
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897

Query: 173  SMKEEL-LKYRSLYGDLDSALSAEE 196
               + +    R L  +LD A  + E
Sbjct: 1898 EESQRINANRRKLQRELDEATESNE 1922



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 92/390 (23%), Positives = 160/390 (41%), Gaps = 83/390 (21%)

Query: 600  QEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFEL-------QSLSLQRRLEQKF 652
            Q+ L  E QL +EEA    QK+   K   +  + + E E+         LS +R+L ++ 
Sbjct: 957  QQMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014

Query: 653  WSQEKNMLVQESQQFK--------HNFLLLFMKLRWFLKRWRQGKV--------LPSEGD 696
             S     L +E ++ K        H  ++  +++R  LK+  + +         L  +  
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDAS 1072

Query: 697  DFLE--------VNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            DF E        +  +K + L  +EEE+ A      A   D   Q   N  +K + +++ 
Sbjct: 1073 DFHEQIADLQAQIAELK-MQLAKKEEELQAA----LARLDDEIAQK--NNALKKIRELEG 1125

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETERAELK----GHTSQMELKTGKGAGERA 804
             + +L   L  ER    + ++Q        E  + EL+       +Q EL+  +   E+ 
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR---EQE 1182

Query: 805  GPDWKAALQREREEQ----QHLLAESYSAVMELTRQLQISER---NWSQEKLQLVER--- 854
                K AL  E        Q +  +   AV ELT QL+  +R   N  + K  L +    
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242

Query: 855  LQGE-------KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH- 906
            L GE       KQ+VE + K+L+ ++ +LQ          +EL           ++K+H 
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-----------NDKVHK 1291

Query: 907  ---DKEAVSEV--ELGGNGLKRTKSVSSMS 931
               + E+V+ +  E  G  +K  K V+S+S
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 71/314 (22%), Positives = 132/314 (42%), Gaps = 23/314 (7%)

Query: 585  LQLVLAEAHDSLRGLQEQLSQERQLRKE-EADNFNQKMVQLKEDQQ--RALLRREFELQS 641
            LQ+   E     +  + Q ++ERQ + E E     QK  QL E++   +  L+ E EL +
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 642  LSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEV 701
             + + R+      QE   ++ E            M+ R   +  R G+ L +E     + 
Sbjct: 912  EAEEMRVRLAAKKQELEEILHE------------MEARLEEEEDR-GQQLQAERKKMAQ- 957

Query: 702  NSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDER 761
              M +L   +EEEE   Q    +  T ++  +   +E I  + D    L +   LL +  
Sbjct: 958  -QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERI 1015

Query: 762  RGLT-ELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD-WKAALQREREEQ 819
              LT  L ++  KAK   + +    +   S++E++  K    R   +  K  L+ +  + 
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 820  QHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKA 879
               +A+  + + EL  QL   E        +L + +  +K    ++++EL+  +S LQ+ 
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI-AQKNNALKKIRELEGHISDLQED 1133

Query: 880  ADPWVLKHSELEKQ 893
             D      ++ EKQ
Sbjct: 1134 LDSERAARNKAEKQ 1147



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 75/341 (21%), Positives = 143/341 (41%), Gaps = 55/341 (16%)

Query: 580  SEIKELQLVLAEAHDSLRGLQEQLSQERQL-------------RKEEADNFNQKM-VQLK 625
            +E+KEL+   ++  +    LQEQL  E +L             +K+E +    +M  +L+
Sbjct: 880  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939

Query: 626  ED----QQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFL---LLFM-- 676
            E+    QQ    R++   Q L L+ +LE++  +++K  L + + + K   L   +L M  
Sbjct: 940  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999

Query: 677  ------KLRWFLKRWRQGKV--LPSEGDDFLEVNSMK--------ELYLLMEEEEINAQH 720
                  K R  L+         L  E +    +  +K        EL + +++EE + Q 
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059

Query: 721  SD--NKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLL----RDERRGLTELQQQFAKA 774
             +   +   GD+      +++ + +AD++  + EL   L     + +  L  L  + A+ 
Sbjct: 1060 LEKLKRKLEGDA------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELT 834
                +  R EL+GH S ++        ERA  +     +R+  E+   L       ++ T
Sbjct: 1114 NNALKKIR-ELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169

Query: 835  RQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQ 875
               Q       QE   L + L  E +  E QV+E++ + +Q
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 31/147 (21%), Positives = 70/147 (47%), Gaps = 2/147 (1%)

Query: 771 FAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQRERE--EQQHLLAESYS 828
           F K K   +  R E +    + EL+  K   ++A  + K   Q+  +  E+++LL E   
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904

Query: 829 AVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHS 888
           A  EL  + +      + +K +L E L   + ++E++    Q   ++ +K A   +    
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 889 ELEKQDNSWKETRSEKIHDKEAVSEVE 915
           +LE+++ + ++ + EK+  +  + ++E
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLE 991



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 81/378 (21%), Positives = 145/378 (38%), Gaps = 42/378 (11%)

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKE------- 626
            D   +  +I +LQ  +AE    L   +E+L        +E    N  + +++E       
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129

Query: 627  -----DQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
                 D +RA  R + E Q   L   LE      E  +    +QQ          +LR  
Sbjct: 1130 LQEDLDSERA-ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----------ELR-- 1176

Query: 682  LKRWRQGKVLPSEGDD-----FLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTP 736
             KR ++  VL    D+       +V  M++ +    EE         +A       + T 
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236

Query: 737  NEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAEL--KGHTSQMEL 794
             +    LA     L +    +  +++ L    Q+     +  E  RAEL  K H  Q E+
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 795  KTGKG-AGERAGPDWK-----AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEK 848
            ++  G   E  G   K     A+L  + ++ Q LL E     + ++ +L+  E   +  +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 849  LQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDK 908
             QL E ++  KQ +E+ +  L  +LS  +K    +    S +E  +   K  + E  +  
Sbjct: 1357 DQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFA---STVEALEEGKKRFQKEIENLT 1412

Query: 909  EAVSEVELGGNGLKRTKS 926
            +   E     + L++TK+
Sbjct: 1413 QQYEEKAAAYDKLEKTKN 1430


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 207/970 (21%), Positives = 377/970 (38%), Gaps = 113/970 (11%)

Query: 15   QLQELRQQLDQASKTCRILQYRLR-------KAERRSLRAAQTGQVDGELIRGLEQDVKV 67
            +L+EL Q+  Q ++   +LQ +L+       +AE   +R A   Q   E++  +E  ++ 
Sbjct: 874  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 933

Query: 68   SKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGT 127
             +D   +L  E + + ++   LEE+ EE      + +L K   + ++++  +  L     
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993

Query: 128  RSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM------------- 174
             +    ++K L++E  +DL   L  A+EE     K LTKL  +++SM             
Sbjct: 994  NNKLSKERK-LLEERISDLTTNL--AEEEEK--AKNLTKLKNKHESMISELEVRLKKEEK 1048

Query: 175  -KEELLKY-RSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANL-LSRRIVELEV 231
             ++EL K  R L GD       E++AD   ++  ELK+ L   EEE    L+R   E+  
Sbjct: 1049 SRQELEKLKRKLEGDASDF--HEQIADL-QAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105

Query: 232  ENRGLRAEMD---DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELL 288
            +N  L+   +    + D         A    +     + GE L  L+  L+   +     
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165

Query: 289  RRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGK 348
            +   A+ E +  +L   L +    HE  V       +   E   E+L   K     L   
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225

Query: 349  VKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD-SAQCVPAPLGETHESHAVRLC 407
             + L+ EN  L   L+    A  +      + +A+  +  ++C          +  V   
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285

Query: 408  RAREAEVLPGLREQAALVSKAIDVL--VADANGFTAGLRLCLDNECADFRLHEAPDNSEG 465
            +  E E + G+  +A    KAI +   VA  +      +  L  E    +L+ +    + 
Sbjct: 1286 Q-NEVESVTGMLNEAE--GKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQL 1341

Query: 466  PRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL--GSQGLSKEI 523
              +   +   L      +Q L       +  L  S K+ Q+  S++  L  G +   KEI
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401

Query: 524  LLAKDLGSDFQ--PPDFRDLPEWEPRIREAF--RTGDLDSK-------PDPSRSFRPYRA 572
               ++L   ++     +  L + + R+++       DLD++           R F    A
Sbjct: 1402 ---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458

Query: 573  EDN-------------DSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQ 619
            E+              ++ A E +   L LA A +     +E+L +  ++ K E ++   
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED--- 1515

Query: 620  KMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLR 679
             +V  K+D  + +   E   ++L  Q   E K   +E    +Q ++  K    +    L+
Sbjct: 1516 -LVSSKDDVGKNVHELEKSKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQALK 1573

Query: 680  WFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEE--EINAQHSDNKACTGD-------- 729
               +R  Q +   +E         + E    +E+E  +     +  K   GD        
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633

Query: 730  SWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHT 789
                    E IK L  ++  +K+    L D R    E+   FA AK   E E+       
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAK---ENEKKAKSLEA 1687

Query: 790  SQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKL 849
              M+L+    A ERA        +++ + ++  LAE  ++ +     LQ  +R       
Sbjct: 1688 DLMQLQEDLAAAERA--------RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 850  QLVERLQGEKQQVE----------QQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
            QL E L+ E+  +E          QQ ++L N L+  +  A        +LE+Q+   KE
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN---KE 1796

Query: 900  TRSEKIHDKE 909
             RS K+H+ E
Sbjct: 1797 LRS-KLHEME 1805



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 205/987 (20%), Positives = 409/987 (41%), Gaps = 141/987 (14%)

Query: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGEL-IR 59
            +L   +  +EE+  + Q+L+ +  + ++    L+ +L + E  + +  Q  +V  E  I+
Sbjct: 923  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKIK 981

Query: 60   GLEQDVKVSKDISMRLHKELEVVEKKRARLEE---ENEELRQRLIETELAKQVLQTELER 116
             LE ++ V  D + +L KE +++E++ + L     E EE  + L + +   + + +ELE 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041

Query: 117  PREHSLKKRGTRSLGKADKKTL------------VQEDSADLKCQLHFAKEE-SALMCKK 163
              +   K R  + L K  +K              +Q   A+LK QL   +EE  A + + 
Sbjct: 1042 RLKKEEKSR--QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 164  LTKLAKENDSMKE--ELLKYRS-LYGDLDSALSAE--------ELADAPHSRETELKVHL 212
              ++A++N+++K+  EL  + S L  DLDS  +A         +L +   + +TEL+  L
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159

Query: 213  KLVEEEANLLSRRIVELEV-------ENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGG 265
                 +  L ++R  E+ V       E R   A++ +M+                A    
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK-------------HAQAVE 1206

Query: 266  ECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCS 325
            E  E L + +R    +++  + L + +A+L  + ++L    AK   EH+    L      
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ--AKQEVEHKKK-KLEAQVQE 1263

Query: 326  VLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAG 385
            + S+ S  E A A     EL+ KV KLQ E   +   L   +  + +  + +    ++  
Sbjct: 1264 LQSKCSDGERARA-----ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 386  DSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRL 445
            D+ + +     ET +   V   + R+ E      E+ +L  +  + + A  N        
Sbjct: 1319 DTQELLQE---ETRQKLNVST-KLRQLE-----EERNSLQDQLDEEMEAKQN-------- 1361

Query: 446  CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKA-------DAVLG 498
             L+   +   +  +    +       + A+       Q+E+   T++        D +  
Sbjct: 1362 -LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 499  CSVKEQQESFSSLPPLGSQ-----GLSK-----EILLAKDLGSDFQPPDFRDLPEWEPRI 548
               + QQE    +  L +Q      L K     + LLA++     +  D RD  E E R 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 549  REAFRTG-------DLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQE 601
            +E             L++K +  R+ +  +AE  D  +S+  ++   + E   S R L+ 
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALET 1539

Query: 602  QLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLV 661
            Q+ + +   +E  D      +Q  ED   A LR E  +Q+L  Q   + +   ++     
Sbjct: 1540 QMEEMKTQLEELEDE-----LQATED---AKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591

Query: 662  QESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHS 721
            ++ Q+  H +          L+  R+ + L +     LE   +K+L L  +    +A   
Sbjct: 1592 RQLQRQLHEY-------ETELEDERKQRALAAAAKKKLE-GDLKDLELQAD----SAIKG 1639

Query: 722  DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERR-------GLTELQQQFAKA 774
              +A       Q    ++ + L D + +  E+    ++  +        L +LQ+  A A
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWK-------AALQREREEQQHLLAESY 827
            +     ++A+L+      EL +   +G  A  D K       A L+ E EE+Q  +    
Sbjct: 1700 ERA--RKQADLEKEELAEELASSL-SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 828  SAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAA-DPWVLK 886
              V + T+Q +      + E+    ++ +  +QQ+E+Q KEL+++L +++ A    +   
Sbjct: 1757 DRVRKATQQAEQLSNELATER-STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815

Query: 887  HSELEKQDNSWKETRSEKIHDKEAVSE 913
             + LE +    +E   ++  +K+A ++
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATK 1842



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 48/205 (23%), Positives = 84/205 (40%), Gaps = 25/205 (12%)

Query: 17   QELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLH 76
            +EL ++L  +      LQ   R+ E R  +  +  + +   +  +   V+ +   + +L 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 77   KELEVV-------EKKRARLEEENEELRQRLIETE-------------LAKQVLQTELER 116
             EL          E  R +LE +N+ELR +L E E             L  ++ Q E + 
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830

Query: 117  PREHSLKKRGTRSLGKADKK----TLVQEDSADLKCQLHFAKEESALMCKKLTKLAKEND 172
             +E   K+  T+SL + DKK     L  ED   +  Q     E+     K+L +  +E +
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890

Query: 173  SMKEEL-LKYRSLYGDLDSALSAEE 196
               + +    R L  +LD A  + E
Sbjct: 1891 EESQRINANRRKLQRELDEATESNE 1915



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 92/390 (23%), Positives = 160/390 (41%), Gaps = 83/390 (21%)

Query: 600  QEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFEL-------QSLSLQRRLEQKF 652
            Q+ L  E QL +EEA    QK+   K   +  + + E E+         LS +R+L ++ 
Sbjct: 950  QQMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007

Query: 653  WSQEKNMLVQESQQFK--------HNFLLLFMKLRWFLKRWRQGKV--------LPSEGD 696
             S     L +E ++ K        H  ++  +++R  LK+  + +         L  +  
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDAS 1065

Query: 697  DFLE--------VNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKV 748
            DF E        +  +K + L  +EEE+ A      A   D   Q   N  +K + +++ 
Sbjct: 1066 DFHEQIADLQAQIAELK-MQLAKKEEELQAA----LARLDDEIAQK--NNALKKIRELEG 1118

Query: 749  TLKELCWLLRDERRGLTELQQQFAKAKATWETERAELK----GHTSQMELKTGKGAGERA 804
             + +L   L  ER    + ++Q        E  + EL+       +Q EL+  +   E+ 
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR---EQE 1175

Query: 805  GPDWKAALQREREEQ----QHLLAESYSAVMELTRQLQISER---NWSQEKLQLVER--- 854
                K AL  E        Q +  +   AV ELT QL+  +R   N  + K  L +    
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235

Query: 855  LQGE-------KQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH- 906
            L GE       KQ+VE + K+L+ ++ +LQ          +EL           ++K+H 
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-----------NDKVHK 1284

Query: 907  ---DKEAVSEV--ELGGNGLKRTKSVSSMS 931
               + E+V+ +  E  G  +K  K V+S+S
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 71/314 (22%), Positives = 132/314 (42%), Gaps = 23/314 (7%)

Query: 585  LQLVLAEAHDSLRGLQEQLSQERQLRKE-EADNFNQKMVQLKEDQQ--RALLRREFELQS 641
            LQ+   E     +  + Q ++ERQ + E E     QK  QL E++   +  L+ E EL +
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 642  LSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEV 701
             + + R+      QE   ++ E            M+ R   +  R G+ L +E     + 
Sbjct: 905  EAEEMRVRLAAKKQELEEILHE------------MEARLEEEEDR-GQQLQAERKKMAQ- 950

Query: 702  NSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDER 761
              M +L   +EEEE   Q    +  T ++  +   +E I  + D    L +   LL +  
Sbjct: 951  -QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERI 1008

Query: 762  RGLT-ELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD-WKAALQREREEQ 819
              LT  L ++  KAK   + +    +   S++E++  K    R   +  K  L+ +  + 
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 820  QHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKA 879
               +A+  + + EL  QL   E        +L + +  +K    ++++EL+  +S LQ+ 
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI-AQKNNALKKIRELEGHISDLQED 1126

Query: 880  ADPWVLKHSELEKQ 893
             D      ++ EKQ
Sbjct: 1127 LDSERAARNKAEKQ 1140



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 75/341 (21%), Positives = 143/341 (41%), Gaps = 55/341 (16%)

Query: 580  SEIKELQLVLAEAHDSLRGLQEQLSQERQL-------------RKEEADNFNQKM-VQLK 625
            +E+KEL+   ++  +    LQEQL  E +L             +K+E +    +M  +L+
Sbjct: 873  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932

Query: 626  ED----QQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFL---LLFM-- 676
            E+    QQ    R++   Q L L+ +LE++  +++K  L + + + K   L   +L M  
Sbjct: 933  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992

Query: 677  ------KLRWFLKRWRQGKV--LPSEGDDFLEVNSMK--------ELYLLMEEEEINAQH 720
                  K R  L+         L  E +    +  +K        EL + +++EE + Q 
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052

Query: 721  SD--NKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLL----RDERRGLTELQQQFAKA 774
             +   +   GD+      +++ + +AD++  + EL   L     + +  L  L  + A+ 
Sbjct: 1053 LEKLKRKLEGDA------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106

Query: 775  KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELT 834
                +  R EL+GH S ++        ERA  +     +R+  E+   L       ++ T
Sbjct: 1107 NNALKKIR-ELEGHISDLQEDLD---SERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162

Query: 835  RQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQ 875
               Q       QE   L + L  E +  E QV+E++ + +Q
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 31/147 (21%), Positives = 70/147 (47%), Gaps = 2/147 (1%)

Query: 771 FAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQRERE--EQQHLLAESYS 828
           F K K   +  R E +    + EL+  K   ++A  + K   Q+  +  E+++LL E   
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897

Query: 829 AVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHS 888
           A  EL  + +      + +K +L E L   + ++E++    Q   ++ +K A   +    
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 889 ELEKQDNSWKETRSEKIHDKEAVSEVE 915
           +LE+++ + ++ + EK+  +  + ++E
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLE 984



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 81/378 (21%), Positives = 145/378 (38%), Gaps = 42/378 (11%)

Query: 574  DNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKE------- 626
            D   +  +I +LQ  +AE    L   +E+L        +E    N  + +++E       
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122

Query: 627  -----DQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWF 681
                 D +RA  R + E Q   L   LE      E  +    +QQ          +LR  
Sbjct: 1123 LQEDLDSERA-ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----------ELR-- 1169

Query: 682  LKRWRQGKVLPSEGDD-----FLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTP 736
             KR ++  VL    D+       +V  M++ +    EE         +A       + T 
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229

Query: 737  NEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAEL--KGHTSQMEL 794
             +    LA     L +    +  +++ L    Q+     +  E  RAEL  K H  Q E+
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 795  KTGKG-AGERAGPDWK-----AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEK 848
            ++  G   E  G   K     A+L  + ++ Q LL E     + ++ +L+  E   +  +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 849  LQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDK 908
             QL E ++  KQ +E+ +  L  +LS  +K    +    S +E  +   K  + E  +  
Sbjct: 1350 DQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFA---STVEALEEGKKRFQKEIENLT 1405

Query: 909  EAVSEVELGGNGLKRTKS 926
            +   E     + L++TK+
Sbjct: 1406 QQYEEKAAAYDKLEKTKN 1423


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 207/964 (21%), Positives = 412/964 (42%), Gaps = 137/964 (14%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL-EQDVKV 67
            +EE   QL + +Q+L+Q     +    RL++     L  A++ ++  + +  L E+ V+V
Sbjct: 267  LEEKTEQLLDCKQELEQMEIELK----RLQQENMNLLSDARSARMYRDELDALREKAVRV 322

Query: 68   SKDIS--MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKR 125
             K  S   R  + L  +E  +AR+EE  E+  Q L+ET   K +L+ +LE          
Sbjct: 323  DKLESEVSRYKERLHDIEFYKARVEELKED-NQVLLET---KTMLEDQLE---------- 368

Query: 126  GTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM----KEELLKY 181
            GTR+  ++DK   +++++  LK +LH  + E  +  KK+ +L +EN ++    K+ + + 
Sbjct: 369  GTRA--RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426

Query: 182  RSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMD 241
              L  +L+      EL++AP            L  E   L S R+++LE+EN+ L   ++
Sbjct: 427  LHLGWELEQISRTSELSEAPQK---------SLGHEVNELTSSRLLKLEMENQSLTKTVE 477

Query: 242  DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKL 301
            +++       G  +++        +  +    L + ++ +E E    ++S    ++ +K 
Sbjct: 478  ELRTTVDSVEGNASKIL-------KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530

Query: 302  LLNELAKFRSEHELDVALSEDSCSVLSEPSQ--EELAAAKLQIGELS--GKVKKLQYENR 357
            L+ E A+     E     SE    +L + ++   +  ++  Q  ++S   +VK ++ EN+
Sbjct: 531  LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 358  VLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAE-VLP 416
            +L  +++              ET ++     +     + +  E +  +  RA E E  L 
Sbjct: 591  ILHESIK--------------ETSSKL-SKIEFEKRQIKKELEHYKEKGERAEELENELH 635

Query: 417  GLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAIL 476
             L ++  L+ K I  L        A  +   + E  + +L +  D+ +    T  + ++ 
Sbjct: 636  HLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL--TFQLESLE 693

Query: 477  VRLSVLQQELNAFTRKADAVLGCSVK------EQQESFSSLPPLGSQGLSKEILLAKDLG 530
               S L +E     R  +++   S+K      E +E  S    L  +GL  E+L A    
Sbjct: 694  KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL-KKGL--ELLKASFKK 750

Query: 531  SDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLA 590
            ++     ++ L     R+++           + ++  +   +E  D    E + LQ  L 
Sbjct: 751  TERLEVSYQGLDIENQRLQKTLE--------NSNKKIQQLESELQD-LEMENQTLQKNLE 801

Query: 591  EAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSL-QRRLE 649
            E   S + L EQL +E +  ++E     +   QL+++ +R  LR++ E++  +L +  ++
Sbjct: 802  ELKISSKRL-EQLEKENKSLEQETSQLEKDKKQLEKENKR--LRQQAEIKDTTLEENNVK 858

Query: 650  QKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLE--VNSMKEL 707
                 +E   L +E   +K + + L              K L  E  + ++     +K L
Sbjct: 859  IGNLEKENKTLSKEIGIYKESCVRL--------------KELEKENKELVKRATIDIKTL 904

Query: 708  YLLMEE---EEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGL 764
              L E+   E++  Q  +N         +       + L D + T  +   LL  +    
Sbjct: 905  VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST-DDRYKLLESKLEST 963

Query: 765  TELQQQFAKAK-ATWETERAELKGHTSQM--ELKTGKGAGERAGPDWKAALQREREEQQH 821
             +   +  + K A  E    E   +  Q+  ELKT K        +++A  QR+ EE+  
Sbjct: 964  LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK-------KNYEALKQRQDEERMV 1016

Query: 822  LLAESYSAV-MELTRQLQISERNWSQEKLQLVE------RLQGEKQQVEQQVKELQNRLS 874
              +   S    +  R+ Q + R   + K +L+E       LQ EKQ ++ Q+K+L+ + +
Sbjct: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076

Query: 875  QLQKAADPWVLKHSELEKQD-NSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEF 933
             LQ  A    L+   +  Q+ N+  +T++ K+       +VE   N    ++S S M++ 
Sbjct: 1077 NLQ--AQILALQRQTVSLQEQNTTLQTQNAKL-------QVE---NSTLNSQSTSLMNQN 1124

Query: 934  ESLL 937
              LL
Sbjct: 1125 AQLL 1128



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 199/952 (20%), Positives = 389/952 (40%), Gaps = 152/952 (15%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGL 61
            LEM +  + + V   +ELR  +D           ++ K E+ + R ++  ++    I   
Sbjct: 465  LEMENQSLTKTV---EELRTTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQE 517

Query: 62   EQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPRE-- 119
            +Q ++  +++S  L KE       +A+LE+  E LR+    +E   ++L+ E E   +  
Sbjct: 518  KQSLQNCQNLSKDLMKE-------KAQLEKTIETLREN---SERQIKILEQENEHLNQTV 567

Query: 120  HSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELL 179
             SL++R   S  +A  K + +E+       LH + +E++    KL+K+  E   +K+EL 
Sbjct: 568  SSLRQRSQIS-AEARVKDIEKENKI-----LHESIKETS---SKLSKIEFEKRQIKKELE 618

Query: 180  KYRSLYGDLDSALSAEELADAPHSRETELKV------HLKLVEEEANLLSRRIVELEVEN 233
             Y+      +    AEEL +  H  E E ++      +LK+  E+   L +   ELE EN
Sbjct: 619  HYK------EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN 672

Query: 234  RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVE---EEAELLRR 290
            R L+  +D  K+          +L        +  E   ELRR+++ ++    +   L+ 
Sbjct: 673  RKLKKTLDSFKNL-------TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725

Query: 291  SSAELEDQNKLLLNEL----AKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELS 346
             + ELE + + L   L    A F+    L+V  S     + ++  Q+ L  +  +I +L 
Sbjct: 726  ENKELESEKEQLKKGLELLKASFKKTERLEV--SYQGLDIENQRLQKTLENSNKKIQQLE 783

Query: 347  GKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRL 406
             +++ L+ EN+ L  NL+   ++S +  +   E  +   +++Q          E+  +R 
Sbjct: 784  SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR- 842

Query: 407  CRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGP 466
               ++AE+     +   L    + +   +    T    + +  E    RL E     E  
Sbjct: 843  ---QQAEI-----KDTTLEENNVKIGNLEKENKTLSKEIGIYKESC-VRLKEL--EKENK 891

Query: 467  RDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLA 526
               K     +  L  L+++L +   K   +     K   E       L   GL+KE LL 
Sbjct: 892  ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE-------LEKIGLNKERLLH 944

Query: 527  KDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQ 586
             +  +D    D   L E +    E+     L+ K +   +    R E++ +Y  ++++  
Sbjct: 945  DEQSTD----DRYKLLESK---LESTLKKSLEIKEEKIAALEA-RLEESTNYNQQLRQEL 996

Query: 587  LVLAEAHDSLRGLQEQ---------LSQERQLRKEEADNFNQKMVQLKE-----DQQRAL 632
              + + +++L+  Q++         +S E    + E+    ++++++K+     ++  A 
Sbjct: 997  KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056

Query: 633  LRRE-----------------FELQSLSLQRRL----EQKFWSQEKN--MLVQESQQFKH 669
            L+ E                  + Q L+LQR+     EQ    Q +N  + V+ S     
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116

Query: 670  NFLLLFMKLRWFLKRWRQGKVLPSEGDDFL-EVNSMKELY--LLMEEEEINAQHSDNKAC 726
            +  L+    +  +    Q   L +E +  + E   +K LY  L+ + E++   H      
Sbjct: 1117 STSLMNQNAQLLI----QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH------ 1166

Query: 727  TGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELK 786
                  +   +EY ++L     TLK     L  E R L +   Q  K K   E     LK
Sbjct: 1167 ------ERQASEY-ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219

Query: 787  GHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERN--- 843
                +M L       E    +  AA  ++   +   L  +YS +++ T  LQ   +N   
Sbjct: 1220 VEQEKMLL-------ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1272

Query: 844  -WSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQD 894
              +  KL+   RL+ E  ++++Q ++L    ++L    +        LE+++
Sbjct: 1273 LLNNSKLEQT-RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 92/391 (23%), Positives = 164/391 (41%), Gaps = 36/391 (9%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVS 68
            +EE     Q+LRQ+L    K    L+ R  + E R ++++    + GE  +   +  + +
Sbjct: 982  LEESTNYNQQLRQELKTVKKNYEALKQR--QDEERMVQSSPP--ISGEDNKWERESQETT 1037

Query: 69   KDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTR 128
            +++ +++   L  VE+  A L+ E + L+ +L + E     LQ ++   +  ++  +   
Sbjct: 1038 REL-LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
            +  +     L  E+S  L  Q      ++A +  + + L  EN+S+ +E    +SLY   
Sbjct: 1097 TTLQTQNAKLQVENST-LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY--- 1152

Query: 189  DSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGG 248
            DS +   E  +  H R+     +  L+ +   L S     LEVE+R L    + +    G
Sbjct: 1153 DSLIKDHEKLELLHERQA--SEYESLISKHGTLKSAH-KNLEVEHRDLEDRYNQLLKQKG 1209

Query: 249  GCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAK 308
                 E  L        E  + L E + H + V  E + L   +  L      LL E   
Sbjct: 1210 QLEDLEKMLKV------EQEKMLLENKNH-ETVAAEYKKLCGENDRLNHTYSQLLKETEV 1262

Query: 309  FRSEH----------ELDVALSEDSCSVLSEPSQE-ELAAAKL--QIGELSGKVKKLQYE 355
             +++H          +L+    E   S L E  Q+ ++ + KL  Q   LS     L+ E
Sbjct: 1263 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1322

Query: 356  NRVLLSNLQRCDLASCQSTRPMLETDAEAGD 386
            NR LL  +Q   L      R +LE + E+ D
Sbjct: 1323 NRHLLDQIQTLML----QNRTLLEQNMESKD 1349



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 145/721 (20%), Positives = 291/721 (40%), Gaps = 127/721 (17%)

Query: 208 LKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGP-----EARLAFSAL 262
           + +HLK + +E +  S  I+EL  E  GL             CG P     E+R   S  
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV- 251

Query: 263 GGGECGESLAELRRHLQFVEEEAELLRRSSAELE----------DQNKLLLNELAKFRSE 312
              E  ++ A++RR  Q +EE+ E L     ELE           +N  LL++    R  
Sbjct: 252 ---ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308

Query: 313 HELDVALSEDSCSVLSEPSQEELAAAKLQIGEL---SGKVKKLQYENRVLLSNLQRCDLA 369
            +   AL E +  V  +  + E++  K ++ ++     +V++L+ +N+VLL         
Sbjct: 309 RDELDALREKAVRV--DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL--------- 357

Query: 370 SCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGL--REQAALVSK 427
               T+ MLE   E     +     L E  + +     +  + E+   +  ++   L+ +
Sbjct: 358 ---ETKTMLEDQLE---GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 428 AIDVLVADANGFTAGLRLC--LDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQE 485
            + + +A        L L   L+       L EAP  S G    +L  + L++L +  Q 
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471

Query: 486 LNAFTRKADAVLGCSVKEQQESFSSLPPL--GSQGLSKEI-LLAKDLGSDFQPPD----- 537
           L     K    L  +V   + + S +  +   +Q LSK++ +L  ++  + Q        
Sbjct: 472 LT----KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527

Query: 538 FRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEA----- 592
            +DL + + ++ +   T  L    +          E  +   S +++   + AEA     
Sbjct: 528 SKDLMKEKAQLEKTIET--LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585

Query: 593 -------HDSLRGLQEQLSQ---ERQLRKEEADNFNQKMVQLKE-DQQRALLRREFELQS 641
                  H+S++    +LS+   E++  K+E +++ +K  + +E + +   L +E EL  
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL-- 643

Query: 642 LSLQRRLEQ-KFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLE 700
             LQ+++   K   ++   L QE+ + +              +  +  K L S  +   +
Sbjct: 644 --LQKKITNLKITCEKIEALEQENSELER-------------ENRKLKKTLDSFKNLTFQ 688

Query: 701 VNSMKELYLLMEEEEINAQHS-DNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRD 759
           + S+++    ++EE +  + + ++  C                +A +++  KEL      
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCAS------------MKMAQLQLENKELESEKEQ 736

Query: 760 ERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQ 819
            ++GL  L+  F K      TER E+      +E                  LQ+  E  
Sbjct: 737 LKKGLELLKASFKK------TERLEVSYQGLDIE---------------NQRLQKTLENS 775

Query: 820 QHLLAESYSAVMELTRQLQISERNWSQEKL--QLVERLQGEKQQVEQQVKELQNRLSQLQ 877
              + +  S + +L  + Q  ++N  + K+  + +E+L+ E + +EQ+  +L+    QL+
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835

Query: 878 K 878
           K
Sbjct: 836 K 836


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 200/1010 (19%), Positives = 390/1010 (38%), Gaps = 151/1010 (14%)

Query: 13   VYQLQELRQQLDQASKTCRILQYRLRKAERR----SLRAAQTGQVDGELI---RGLEQDV 65
            + QLQ  ++ L    + C  L     + E R    S R  +  +++ EL    R LE + 
Sbjct: 900  ILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDEC 959

Query: 66   -KVSKDIS------MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPR 118
             ++ K+I       ++  KE    E K   L EE E L + + +   A +V+Q   ++  
Sbjct: 960  FELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTL 1019

Query: 119  EH-SLKKRGTRSLGKADKK----------TLVQEDSADLKCQLHFAKEESALMCKK--LT 165
            +   +++    SL KA+ K           L QE  A + C+    K E  L   +  + 
Sbjct: 1020 DDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESME 1079

Query: 166  KLAKENDSMKEELLKYRSLYGDLDSALSAEE-LADAPHSRETELKVHLKLVEEEANLLSR 224
             L      + EEL K       ++S +  E+ L         EL+  +K ++E+      
Sbjct: 1080 NLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERT 1139

Query: 225  RIVELEVENRGLRAEMDDMKDHGGGCGGP-----------------------EARLAFSA 261
               ++E E   L  ++ D+ +     GG                        EA L F  
Sbjct: 1140 TRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFET 1199

Query: 262  LGGG---ECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVA 318
                      +SLAEL   ++ +++  + L +  ++L+ +   LL  + +         A
Sbjct: 1200 TSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAK----A 1255

Query: 319  LSEDSCSVLSEPSQEELAAAKLQ-----IGELSGKVKKLQYENRVLLSNLQRCDLASCQS 373
             +E  C++  E   E  A AKL        +L+ +  KL  E+   L  L+  +    Q 
Sbjct: 1256 NAEKLCTLYEERLHE--ATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQL 1313

Query: 374  TRPMLETDAEAGD-SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVL 432
            +R       +  D   Q       ++  +HA++  + R+ ++L    E+   V   +   
Sbjct: 1314 SREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQ-RDCDLLREQYEEEQEVKAELHRT 1372

Query: 433  VADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRK 492
            ++  N      R+  +N             +E   D K    + +RL    + +     +
Sbjct: 1373 LSKVNAEMVQWRMKYENNVIQ--------RTEDLEDAK--KELAIRLQEAAEAMGVANAR 1422

Query: 493  ADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAF 552
              ++     + Q E   +L  LG    +   L  K L S       + L +W+ +  E+ 
Sbjct: 1423 NASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSG------KALADWKQKHEESQ 1476

Query: 553  RTGDLDSKPDPSRSFRPYRAEDN--------DSYASEIKELQLVLAEAHDSLRGLQEQLS 604
               D   K   + S    + ++         ++   E K LQ  ++   + +R   + L+
Sbjct: 1477 ALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLT 1536

Query: 605  QERQLRKEEADNFNQKMVQLKEDQQRALLRRE-----FELQSLSLQRRLEQKFWSQEKNM 659
            +  +++K   +   +  V L E+ + AL R E     F+L+ L  +  LE+K   ++   
Sbjct: 1537 EMEKVKKLIEEEKTEVQVTL-EETEGALERNESKILHFQLELLEAKAELERKLSEKD--- 1592

Query: 660  LVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQ 719
              +E + F+         L+           L SE    +EV  +K+      EE++N  
Sbjct: 1593 --EEIENFRRKQQCTIDSLQ---------SSLDSEAKSRIEVTRLKKKM----EEDLNEM 1637

Query: 720  HSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWE 779
                      S      +E  K+L  +++ +K+L   L D  +  ++L++Q A A+    
Sbjct: 1638 ELQL------SCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNS 1691

Query: 780  TERAELKGHTSQMELKTGKG----------AGERAGPDW-------------KAALQRER 816
              ++EL+   S  E +T +G          A ER    +             +A + R +
Sbjct: 1692 LLQSELEDLRSLQE-QTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQ 1750

Query: 817  EEQQHLLAESYSAVMELTRQLQISERNWSQE---KLQLVERLQGEKQQVEQQVKELQNRL 873
            +E + ++ E  +A  E  ++  I   N S+E   K   +  L+  ++ +EQ + +LQ RL
Sbjct: 1751 KEAEEVVQECQNAE-EKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRL 1809

Query: 874  SQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKR 923
            ++ ++ A   +    +++K ++  +E   E   +    +E + G   L+R
Sbjct: 1810 AEAEQMA--LMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLER 1857



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 70/327 (21%), Positives = 143/327 (43%), Gaps = 28/327 (8%)

Query: 33   LQYRLRKAERRSLRAAQT-GQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEE 91
            ++ +L  A R+   A ++ GQ+  + I+ L+  +  S  ++  L +++ V E++ + L+ 
Sbjct: 1637 MELQLSCANRQVSEATKSLGQLQIQ-IKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQS 1695

Query: 92   ENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLH 151
            E E+LR    +TE  +++ + EL    E  +    T++     +K  ++ D A ++ +  
Sbjct: 1696 ELEDLRSLQEQTERGRRLSEEELLEATER-INLFYTQNTSLLSQKKKLEADVARMQKEAE 1754

Query: 152  FAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVH 211
               +E     +K  K A E  ++ EEL K +      D+    E   +      T+L+  
Sbjct: 1755 EVVQECQNAEEKAKKAAIEAANLSEELKKKQ------DTIAHLERTRENMEQTITDLQKR 1808

Query: 212  LKLVEEEANLLSRR-IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGES 270
            L   E+ A + SR+ I +LE   R L  E++            E R +  A  G      
Sbjct: 1809 LAEAEQMALMGSRKQIQKLESRVRELEGELEG-----------EIRRSAEAQRGAR---- 1853

Query: 271  LAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEP 330
               L R ++ +  +AE  +++ + ++ Q   L  ++  ++ + E+    +    S   + 
Sbjct: 1854 --RLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKK- 1910

Query: 331  SQEELAAAKLQIGELSGKVKKLQYENR 357
             Q EL   K +      +V KL+ + R
Sbjct: 1911 QQHELNEVKERAEVAESQVNKLKIKAR 1937


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 186/937 (19%), Positives = 377/937 (40%), Gaps = 110/937 (11%)

Query: 16   LQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRL 75
            L+E +Q++ Q  K C  ++Y+                   E I  LE+ VK  + +    
Sbjct: 2014 LKEKQQEVKQLQKDC--IRYQ-------------------EKISALERTVKALEFVQTES 2052

Query: 76   HKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADK 135
             K+LE+ ++  A+  E  ++ +  L   ++     Q+E  R    +LK +      K   
Sbjct: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112

Query: 136  KTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALS-- 193
            K+ +++   DL+ +L  A+E+     K+   + ++ D+++ E +      G++   L+  
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKH---LKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169

Query: 194  ---AEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENR----GLRAEMDDMKDH 246
                ++L +   S  T+L    K +    +   R I E +   R     ++++ ++++  
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK 2229

Query: 247  GGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEE----EAELLRRSSAELEDQNKLL 302
               C   + +L   ++   E   +++ L    Q  E     E +L ++    L+ +NK L
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289

Query: 303  LNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVL--L 360
            L++L + R        L   S + L++  + EL + K Q+ +LS  ++K + +   L  +
Sbjct: 2290 LSQLEETRH-------LYHSSQNELAK-LESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2341

Query: 361  SNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLRE 420
               Q  D+ + + +   LETD +A              HE         +E +++  L  
Sbjct: 2342 IRQQEADIQNSKFSYEQLETDLQASREL------TSRLHEE-----INMKEQKIISLLSG 2390

Query: 421  QAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAI-LVRL 479
            +   +  AI  L    +     L   L  E  +  + E  +     +  +L+  +  ++ 
Sbjct: 2391 KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKK 2450

Query: 480  SVLQQ--ELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPD 537
              +QQ  +L++F +   ++      ++         L  + LS  I+L KD        +
Sbjct: 2451 ENIQQKAQLDSFVKSMSSL----QNDRDRIVGDYQQLEERHLS--IILEKDQLIQEAAAE 2504

Query: 538  FRDLPEWEPRIREAFRTGDLDSK-PDPSRSFRPYRAEDN------DSYASEIKELQLVL- 589
               L E    +R      DL+S+          YR + N      DS   ++ E+QL   
Sbjct: 2505 NNKLKEEIRGLRS--HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN 2562

Query: 590  AEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLE 649
             E  +    L+E+L +  +  ++   +FN     L+E++Q   L +E E   +S+ +   
Sbjct: 2563 KELENKYAKLEEKLKESEEANEDLRRSFN----ALQEEKQD--LSKEIESLKVSISQLTR 2616

Query: 650  QKFWSQEKNMLVQESQQFK------HNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNS 703
            Q    QE+  L     Q K      H    LF   +  +    +  V        ++  +
Sbjct: 2617 QVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVC-------VQKEA 2669

Query: 704  MKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRG 763
             K++  + ++ +   +H  + A    + T+ T  E +  LA   V +++   ++  E +G
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETE-TAEERVAELARDLVEMEQKLLMVTKENKG 2728

Query: 764  LTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLL 823
            LT   Q F ++ ++ +  R        +++ K      E A    +  L RER+    LL
Sbjct: 2729 LTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA---LL 2785

Query: 824  AESYSAVMELTRQLQISE-RNWSQEKLQLVERLQGEKQQVE---QQVKELQNRLSQLQKA 879
            +E+ +  M  T +  +S     +Q+ L   E+L     Q+E    QV+     ++ LQ  
Sbjct: 2786 SET-AFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE 2844

Query: 880  ADP-WVLKHSELEKQDNSWKETRSEKIHDKEAVSEVE 915
             D  W    +ELEK   S +  +        + +EV+
Sbjct: 2845 RDHLW----NELEKFRKSEEGKQRSAAQPSTSPAEVQ 2877



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 176/947 (18%), Positives = 381/947 (40%), Gaps = 130/947 (13%)

Query: 11   EDVYQLQELRQQLDQASKTCRILQYRLRKAE------RRSLRAAQTGQVDGELIRGLEQD 64
            E+V+QLQE   Q+++       L+    +AE      ++ L ++Q      E +R L+  
Sbjct: 1337 EEVFQLQE---QINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPK 1393

Query: 65   VKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELE-RPREHS-- 121
            +   + +  +  +++  +  + +  E    +++  +IE E   + L T+LE + +EH   
Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER 1453

Query: 122  LKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY 181
            +K+          K   + E+S   K Q+   K ++AL+ +K  +  KEN S++EEL   
Sbjct: 1454 IKQLQVELCEMKQKPEEIGEESR-AKQQIQ-RKLQAALISRK--EALKENKSLQEELSLA 1509

Query: 182  RSLYGDLDSALSAEELADAPHSRETELKV-HLKLVEEEANLLSRRIVELEVENRGLRAEM 240
            R     L  +L+  E   +  ++E +  +  L L++EE + L   +    +EN+ L +  
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSC 1569

Query: 241  DDMKDHGGGCGGPEARLA--FSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQ 298
            + +K    G    + +L     +L   +  ES     +H + +++E E+L +S   + ++
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE-LQKEYEILLQSYENVSNE 1628

Query: 299  NKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRV 358
             + + + +   R E + ++     S     + ++++L  A+ ++ E+  K++K     + 
Sbjct: 1629 AERIQHVVEAVRQEKQ-ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQ 1687

Query: 359  LLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGL 418
             +  L+       ++ R   E       + +C+   L             A   E L  +
Sbjct: 1688 KILELEE------ENDRLRAEVHPAGDTAKECMETLLSS----------NASMKEELERV 1731

Query: 419  REQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVR 478
            + +   +SK    L+++ +         L  E  D + H+   N                
Sbjct: 1732 KMEYETLSKKFQSLMSEKDS--------LSEEVQDLK-HQIEGN---------------- 1766

Query: 479  LSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDF 538
               + ++ N               E+ ++ +++   G+Q +  E      L    +P   
Sbjct: 1767 ---VSKQAN-----------LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS 1812

Query: 539  RDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRG 598
              +P  +             + P  S+ F  +  ++ ++Y  +I +L+       + + G
Sbjct: 1813 ESVPSAK------------SANPAVSKDFSSH--DEINNYLQQIDQLK-------ERIAG 1851

Query: 599  LQEQLSQERQLRK--EEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQE 656
            L+E+  + ++  +  E   N     +  K+ + + L     ++  L+ Q + E    ++ 
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911

Query: 657  KNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEI 716
            K    +E    +   +    +L   +  + Q        ++ LE + MK L   + E E 
Sbjct: 1912 KETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE-SEMKNLKKCVSELEE 1970

Query: 717  NAQHSDNKACTGDSWTQNTPNEYIKTLADM------KVTLKELCWLLRDERRGLTELQQQ 770
              Q    +    +S       EY++ +         K   KEL  LL+++++ + +LQ+ 
Sbjct: 1971 EKQQLVKEKTKVES---EIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD 2027

Query: 771  F----AKAKATWETERA-ELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAE 825
                  K  A   T +A E     SQ +L+  K        +   A++  ++ Q  L   
Sbjct: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITK-------ENLAQAVEHRKKAQAEL--A 2078

Query: 826  SYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVL 885
            S+  +++ T   Q        + L+L + LQ  K+ V+ Q+K+    L +  + A+   L
Sbjct: 2079 SFKVLLDDT---QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2135

Query: 886  KHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSE 932
            K  E +         R EK+H +E + E+++  N  K+ K V  + E
Sbjct: 2136 K--EKKNMQEKLDALRREKVHLEETIGEIQVTLN--KKDKEVQQLQE 2178



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 207/1066 (19%), Positives = 418/1066 (39%), Gaps = 189/1066 (17%)

Query: 3    EMRDVYMEEDVYQ--LQELRQQLDQASKTCRILQYRLRKAER--RSLRAAQTGQVDGELI 58
            ++ +    E+ +Q  ++++ Q L   +    +LQ  + + +   + L  + T   DG+ +
Sbjct: 1079 DLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138

Query: 59   RGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPR 118
              +++ V +S   +         +E+K   LE+E E+L+++L E   +++ +        
Sbjct: 1139 ALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI-------- 1190

Query: 119  EHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL 178
               LKK               QE    L+ +L   K++   + ++  + +KEN+++ ++L
Sbjct: 1191 ---LKK--------------AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233

Query: 179  LKYR-----SLYGDLDSALSAEELADAPHSRETELKV----HLKLV------------EE 217
             + +     S+ G L S    E  +  P   E   K     H + V             E
Sbjct: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293

Query: 218  EANLLS--RRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELR 275
            +A+ L     + +++ + + + AE  ++          E +++ +     +  E + +L+
Sbjct: 1294 DASALQGGTSVAQIKAQLKEIEAEKVEL----------ELKVSSTTSELTKKSEEVFQLQ 1343

Query: 276  RHLQFVEEEAELLRRSSAELED-----QNKLLLNELAKFRSEHELDVALSEDSCSVLSEP 330
              +     E E L+  S E E      Q KL  ++L     EH  ++    D    L   
Sbjct: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403

Query: 331  SQEELAAAKLQIGELSGKVKKLQ---YENRVLLSNLQ-RCDLASCQSTRPMLETDAEAGD 386
             +E+++    Q+ E    + K+Q    E   L+  L  + ++ + +    + +   E  +
Sbjct: 1404 KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCE 1463

Query: 387  SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLC 446
              Q  P  +GE  ES A +  + +    L   R++A   +K++   ++ A G    L   
Sbjct: 1464 MKQ-KPEEIGE--ESRAKQQIQRKLQAALIS-RKEALKENKSLQEELSLARGTIERLTKS 1519

Query: 447  LDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQE 506
            L    AD     +  N E  +DT     +L RL++LQ+E +    + D     S+ E Q 
Sbjct: 1520 L----ADVESQVSAQNKE--KDT-----VLGRLALLQEERDKLITEMDR----SLLENQS 1564

Query: 507  SFSSLPPL--GSQGLSKEI-LLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD--LDSKP 561
              SS   L    +GL+++   L K++ S  +     +  EW+ + +E  +  +  L S  
Sbjct: 1565 LSSSCESLKLALEGLTEDKEKLVKEIES-LKSSKIAESTEWQEKHKELQKEYEILLQSYE 1623

Query: 562  DPSRS-------FRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEA 614
            + S             R E  + Y  +++  +    E    L+  ++++ + ++  ++ A
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYG-KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682

Query: 615  DNFNQKMVQLKEDQQR-----------------------ALLRREFELQSLSLQRRLEQK 651
             +  QK+++L+E+  R                       A ++ E E   +  +  L +K
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET-LSKK 1741

Query: 652  FWS--QEKNMLVQESQQFKHNFLLLFMK---LRWFLKRWRQGKVLPSEGDDFLEVNSMKE 706
            F S   EK+ L +E Q  KH       K   L    K   Q  V   EG   +   + ++
Sbjct: 1742 FQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVT-EEGTQSIPGETEEQ 1800

Query: 707  LYLLME-----EEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTL----------K 751
              L M       E + +  S N A + D  + +  N Y++ +  +K  +          K
Sbjct: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK 1860

Query: 752  ELCWLLRDERRGLTE---------------------LQQQF-------AKAKATWETERA 783
            E    L +E+  L                       L QQ         K K T E E+ 
Sbjct: 1861 EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD 1920

Query: 784  ELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERN 843
            +L+        +     G        A ++ E  E +    +   + +E  +Q  + E+ 
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT 1980

Query: 844  WSQEKL--QLVERLQGEKQQ---------VEQQVKELQNRLSQLQKAADPWVLKHSELEK 892
              + ++  + +E++QG +++         +++ +KE Q  + QLQK    +  K S LE+
Sbjct: 1981 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040

Query: 893  QDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLD 938
               + +  ++E   D E   E  L      R K+ + ++ F+ LLD
Sbjct: 2041 TVKALEFVQTESQKDLEITKE-NLAQAVEHRKKAQAELASFKVLLD 2085



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 195/987 (19%), Positives = 371/987 (37%), Gaps = 147/987 (14%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVS 68
            +E ++  L++    L  + + C+  +  L    R+     Q  +   E    LE D++ S
Sbjct: 2310 LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ---LETDLQAS 2366

Query: 69   KDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTR 128
            ++++ RLH+E+ + E+K   L    EE          A QV   EL +  +  +K+    
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEE----------AIQVAIAELRQQHDKEIKELENL 2416

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKY----RSL 184
               + ++  +++E++         A +++  + + L  + KEN   K +L  +     SL
Sbjct: 2417 LSQEEEENIVLEEENKK-------AVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL 2469

Query: 185  YGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVE---LEVENRGLRAEMD 241
              D D  +   +  +         + HL ++ E+  L+     E   L+ E RGLR+ MD
Sbjct: 2470 QNDRDRIVGDYQQLE---------ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520

Query: 242  DMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE-DQNK 300
            D+                      +    L + R  L  V    +  ++   E++  QNK
Sbjct: 2521 DLNSE-----------------NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK 2563

Query: 301  LLLNELAKFRSEHELDVALSED---SCSVLSEPSQE---ELAAAKLQIGELSGKVKKLQY 354
             L N+ AK   + +     +ED   S + L E  Q+   E+ + K+ I +L+ +V  LQ 
Sbjct: 2564 ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE 2623

Query: 355  ENRVLLSNLQ---------RCDLASCQSTRPMLETDAEAGDSAQCVPAPLGET------- 398
            E  + L + Q         R       S + + E + E     +     +GE        
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKE 2683

Query: 399  -----HESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECAD 453
                 H++  +R       E +  L      + + + ++  +  G TA ++       + 
Sbjct: 2684 LKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ-SFGRSMSS 2742

Query: 454  FRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSV----KEQQESFS 509
             +      N E     +   A L  L+ L+++     R+ DA+L  +       ++ S S
Sbjct: 2743 LQNSRDHANEELDELKRKYDASLKELAQLKEQ-GLLNRERDALLSETAFSMNSTEENSLS 2801

Query: 510  SLPPLGSQGLSKE---ILLAKDLGSDF-QPPDF-RDLPEWEPRIREAFRTGDLDSKPDPS 564
             L  L  Q LSK+   + L+  L   + Q   F + +   +      +   +   K +  
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861

Query: 565  RSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL 624
            +     +   + +    +K+    L    D L    + L Q+     +E    +    QL
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921

Query: 625  KEDQQRA----LLRREFELQSLSLQR-----RLEQKFW-------SQEKNMLVQESQQFK 668
            +E Q +     +++ E   ++LS Q      R+E+  W        ++  M + +  Q  
Sbjct: 2922 QEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981

Query: 669  HNFLLLFMKLRWFLKRWRQGKV-LPSEGDDFLEVNSMKELYLLMEEEEINAQHSDN-KAC 726
             +   L  +LR    + +  KV    +       +      L+ E E +  Q +D+ K  
Sbjct: 2982 SHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEI 3041

Query: 727  TGDSWTQNTPNEYIKTLADMKVTLK-ELCWLLRDERRGLTELQQQFAKAK---ATWETER 782
                      N     L + K TL  +LC    D  + L E QQ +       A  E + 
Sbjct: 3042 HQKELRIQQLNSNFSQLLEEKNTLSIQLC----DTSQSLRENQQHYGDLLNHCAVLEKQV 3097

Query: 783  AELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISER 842
             EL+     +++  G        P  K  + R+ + ++  L E   +  E  +QL     
Sbjct: 3098 QELQAGPLNIDVAPG-------APQEKNGVHRKSDPEE--LREPQQSFSEAQQQL----C 3144

Query: 843  NWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRS 902
            N  QE  +L + L+ E+ Q       L     Q+++      L+HSE       W  +R+
Sbjct: 3145 NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR------LEHSE-------WDSSRT 3191

Query: 903  EKIHD---KEAVSEVELGGNGLKRTKS 926
              I     +E    ++L  N  +RT+S
Sbjct: 3192 PIIGSCGTQEQALLIDLTSNSCRRTRS 3218



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 202/952 (21%), Positives = 373/952 (39%), Gaps = 166/952 (17%)

Query: 5    RDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQ-----TGQVDGELIR 59
            +DV +E    +L +++ Q  + S   R LQ +L+  E   L  A+     + +V+ EL +
Sbjct: 808  KDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE-ELSQ 866

Query: 60   GLEQ-DVKVSKDISMRLHKELEV------VEKKRARLEEENEELRQRLIETELAKQVLQT 112
             L Q +++++K   + L K+ +V      +E+K  ++ E +  + +++++    K  L  
Sbjct: 867  ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV 926

Query: 113  ELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKEND 172
            E++  +E    +    S  +  KK  V+ED+           E S+ + +   +++    
Sbjct: 927  EIKTLKE----QLNLLSRAEEAKKEQVEEDN-----------EVSSGLKQNYDEMSPAGQ 971

Query: 173  SMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLL--SRRIVELE 230
              KEEL     L    ++     +L  A  +R+  L+   +L EE ANL   S++ + L 
Sbjct: 972  ISKEELQHEFDLLKK-ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030

Query: 231  VENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRR 290
               RG   E  + K++   C               +C E    L++ +   E E + +R+
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVT------------SKCQEIEIYLKQTISEKEVELQHIRK 1078

Query: 291  SSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
               E             K  +E +    + + + ++  + +Q +L  A++          
Sbjct: 1079 DLEE-------------KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS--------- 1116

Query: 351  KLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCV--------PAPLGETH--- 399
                EN+ ++  L   +            TDA  GDS   V        P      H   
Sbjct: 1117 ----ENQAIIQKLITSN------------TDASDGDSVALVKETVVISPPCTGSSEHWKP 1160

Query: 400  ESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADF-RLHE 458
            E     L   +E E L    ++A    KAI   +  A      LR  L  +  D+ RL E
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAI---LKKAQEKERHLREELKQQKDDYNRLQE 1217

Query: 459  APDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQG 518
              D  E  ++ + I   L +L +  +E        D  L  +  +QQES SS P     G
Sbjct: 1218 QFD--EQSKENENIGDQLRQLQIQVRE------SIDGKLPST--DQQESCSSTP-----G 1262

Query: 519  LSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSY 578
            L + +  A +        +    P+W     +A       S      S    +A+  +  
Sbjct: 1263 LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA-------SALQGGTSVAQIKAQLKEIE 1315

Query: 579  ASEIKELQLVLAEAHDSLRGLQEQLSQ-ERQLRKEEADNFNQKMVQLKEDQQRALLRREF 637
            A ++ EL+L ++     L    E++ Q + Q+ K+  +  + K V             E 
Sbjct: 1316 AEKV-ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVS-----------HEA 1363

Query: 638  ELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDD 697
            E+ + SLQ++LE              S Q +   L    +L+  L   +  K++  + +D
Sbjct: 1364 EVHAESLQQKLE--------------SSQLQIAGLEHLRELQPKLDELQ--KLISKKEED 1407

Query: 698  FLEVN---SMKELYLLMEEEEINAQHSDNKAC-TGDSWTQNTPNEYIKTLADMKVTLKEL 753
               ++   S KE  L   + EI  Q    KA  T         +E IK L      +K+ 
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467

Query: 754  CWLLRDERRGLTELQQQFAKAKATWETERAELKGHTS-QMELKTGKGAGERAGP---DWK 809
               + +E R   ++Q+   K +A   + +  LK + S Q EL   +G  ER      D +
Sbjct: 1468 PEEIGEESRAKQQIQR---KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE 1524

Query: 810  AALQREREEQQHLLA-------ESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQV 862
            + +  + +E+  +L        E    + E+ R L +  ++ S     L   L+G  +  
Sbjct: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL-LENQSLSSSCESLKLALEGLTEDK 1583

Query: 863  EQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEV 914
            E+ VKE+++  S     +  W  KH EL+K+     ++     ++ E +  V
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHV 1635



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 220/1044 (21%), Positives = 407/1044 (38%), Gaps = 143/1044 (13%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVS 68
            ++E +  L+E +Q+  + S+T             ++   +Q    DGEL + L+++V   
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLE---------NEKNTLLSQISTKDGEL-KMLQEEVTKM 1894

Query: 69   KDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTR 128
              ++ ++ +EL  V K +   EEE ++L +RL+  +LA+             S+      
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLM-NQLAE----------LNGSIGNYCQD 1943

Query: 129  SLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDL 188
                  K  L++ +  +LK  +   +EE   + K+ TK+  E++  KE L K +    + 
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV--ESEIRKEYLEKIQGAQKEP 2001

Query: 189  DSALSAEELADAPHSRETELKVHLK---LVEEEANLLSRRIVELEVENRGLRAEMDDMKD 245
             +   A+EL +    ++ E+K   K     +E+ + L R +  LE      + +++  K+
Sbjct: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061

Query: 246  HGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQ---NKLL 302
            +          LA +     +    LA  +  L   + EA  +   + +L+ +   NK  
Sbjct: 2062 N----------LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111

Query: 303  LNELAKFRSEHELDVALSEDSCSVLSEPS--QEELAAAKLQ-------IGELSGKVKKLQ 353
            +    K + E +L+  L +     L E    QE+L A + +       IGE+   + K  
Sbjct: 2112 VKSQMKQKDE-DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170

Query: 354  YENRVLLSNLQR--CDLASCQSTRPMLETDAE-AGDSAQCVPAPLGETHES--HAVRLCR 408
             E + L  NL      LA+   +   L+ D +   D A+       +  +S    +RL +
Sbjct: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL-K 2229

Query: 409  AREAEVLPGLREQAALVSKAIDVLVADAN------GFTAGLRLCLDNECADFRLHEAPDN 462
                 VL     Q ++  + + + ++            A   + L  +  D    E  + 
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289

Query: 463  SEGPRDTK-LIHAILVRLSVLQQELNA----FTRKADAVLGCSVKEQQESFSSLPPLGSQ 517
                 +T+ L H+    L+ L+ EL +     T  ++++  C  KEQ+ +   +      
Sbjct: 2290 LSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQQEA 2347

Query: 518  GLSKEILLAKDLGSDFQPP-DFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDND 576
             +       + L +D Q   +       E  ++E      L  K +   + +   AE   
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEE---AIQVAIAELRQ 2404

Query: 577  SYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQL----KEDQQRAL 632
             +  EIKEL+ +L++  +    L+E+        K+  D  NQ M  L    KE+ Q+  
Sbjct: 2405 QHDKEIKELENLLSQEEEENIVLEEE-------NKKAVDKTNQLMETLKTIKKENIQQKA 2457

Query: 633  LRREFELQSLSLQ----------RRLEQKFWS--QEKNMLVQESQQFKHNFLLLFMKLRW 680
                F     SLQ          ++LE++  S   EK+ L+QE+    +           
Sbjct: 2458 QLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK---------- 2507

Query: 681  FLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEIN----AQHSDNKACTGDSWTQNTP 736
             LK   +G  L S  DD    N+  +  L+   E++N     + S  K        QN  
Sbjct: 2508 -LKEEIRG--LRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN-- 2562

Query: 737  NEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKT 796
             E     A ++  LKE      D RR    LQ++    K     E   LK   SQ+  + 
Sbjct: 2563 KELENKYAKLEEKLKESEEANEDLRRSFNALQEE----KQDLSKEIESLKVSISQLTRQV 2618

Query: 797  GKGAGERAGPDWKAALQREREEQQHLLA---ESYSAVMELTRQLQISERNWSQEKLQLVE 853
                 E     + A L+ + EE   L A    S   + EL  +L   ++  +++  ++ +
Sbjct: 2619 TALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678

Query: 854  RL--------------QGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKE 899
            +L              + E +  E++V EL   L ++++       ++  L  Q  S+  
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGR 2738

Query: 900  TRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAF 959
            + S   + ++  +E EL  + LKR K  +S+ E   L +        DA    L +  AF
Sbjct: 2739 SMSSLQNSRDHANE-EL--DELKR-KYDASLKELAQLKEQGLLNRERDA----LLSETAF 2790

Query: 960  GFVSSEPGDPEKDTKEKPGLSSRD 983
               S+E        K    L S+D
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKD 2814



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 198/1024 (19%), Positives = 386/1024 (37%), Gaps = 157/1024 (15%)

Query: 1    MLEMRDVYMEEDVYQLQELRQQLDQASKTC--RILQYRLR-KAERRSLRA------AQTG 51
            ++E++D+  ++DV QLQ+  + L +  K    +I + +L  KA+  SL        AQ G
Sbjct: 61   VVELKDIIRQKDV-QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGG 119

Query: 52   QVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQ 111
             V   L    + + ++SK       +E+E+ EK + +L+E+ E     LI T L  Q+ Q
Sbjct: 120  TV---LPTEPQSEEQLSKHDKSSTEEEMEI-EKIKHKLQEKEE-----LIST-LQAQLTQ 169

Query: 112  TELERPREHS----------------------LKKRGTRSLGKADKKTLVQEDSADLKCQ 149
             + E+P + S                      L+ + +++  +   + +V+E  A  + Q
Sbjct: 170  AQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ 229

Query: 150  LHFAKEE----------SALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELAD 199
            +   ++E             M +KL  L ++ +  +E L+    +   L   L+A E  +
Sbjct: 230  VRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN 289

Query: 200  APHSRETE--------LKVHLKLVEEEANLLSRRIVELEVENR-----GLRAEMDDMKDH 246
               S++ +        L+  ++   EE+ +L  ++ ELEV  R      L+ EM  + + 
Sbjct: 290  QILSQQLQQMEAEHNTLRNTVETEREESKILLEKM-ELEVAERKLSFHNLQEEMHHLLEQ 348

Query: 247  GGGCGGPEARLA--FSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLN 304
                G  +A L   +SAL      E + E   H+  +++  + L+ +   L+DQN  LL 
Sbjct: 349  FEQAGQAQAELESRYSALEQKHKAE-MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ 407

Query: 305  ELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQ 364
            +  +   +    +   ED     S+   + L    LQ  E + +       N    +  +
Sbjct: 408  DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE 467

Query: 365  RCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAAL 424
              ++AS Q     LE +  A   +      L   +E  + ++    EA+   G  ++   
Sbjct: 468  E-NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI-TLLEAQNRTGEADREVS 525

Query: 425  VSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQ 484
                +D+    ++      +  L+N  +              +  K +  +L+ +   Q+
Sbjct: 526  EISIVDIANKRSSSAEESGQDVLENTFS--------------QKHKELSVLLLEMKEAQE 571

Query: 485  ELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLS--KEILLAKDLGSDF--QPPDFRD 540
            E+     +           +      +  +  +G++  K  +  +D G DF   P +   
Sbjct: 572  EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631

Query: 541  LP---------EWEPRIREAFRTGDL-----DSKPDPSRSFRPY------RAEDNDSYAS 580
            LP         E + R  E     D       +K D  +S            ++ +   S
Sbjct: 632  LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKS 691

Query: 581  EIKELQLVLAEAHD----SLRGLQEQLSQERQL---RKEEADNFNQKMVQLKEDQQRAL- 632
            +I EL+L   +A +    +L    +++S   QL    K+ ADN +     L E++ + L 
Sbjct: 692  QILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLS 751

Query: 633  ---------------LRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMK 677
                            + E  L     QRRL+ +  +   N+L ++            +K
Sbjct: 752  QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK 811

Query: 678  LRWFLKRWRQGKVLPSEGDDF-LEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTP 736
            +          +VL +E DD  L+ +    L   ++ +  N +    +         +  
Sbjct: 812  I----------EVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861

Query: 737  NEYIKTLADMKVTLKELCWLLRDERRGLTELQQQF-AKAKATWETERAELKGHTSQMELK 795
             E  + L+  ++ + ++  LL +++R +  LQQ    K +   E   +  +      E K
Sbjct: 862  EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921

Query: 796  TGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERL 855
               G   +   +    L R  E ++  + E       L +            K +L    
Sbjct: 922  FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981

Query: 856  QGEKQQVEQQVKELQ----NRLSQLQKAADPWVLKHSELEKQDNSWKE------TRSEKI 905
               K++ EQ+ ++LQ    NR   LQ+ +    L+      +D S KE       R E  
Sbjct: 982  DLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKDESKKEIPLSETERGEVE 1038

Query: 906  HDKE 909
             DKE
Sbjct: 1039 EDKE 1042



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 87/405 (21%), Positives = 167/405 (41%), Gaps = 38/405 (9%)

Query: 17  QELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLH 76
           Q +R  LD        +++     E    R A   Q+  EL     +D+   KD+ ++  
Sbjct: 24  QNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVEL-----KDIIRQKDVQLQQK 78

Query: 77  KELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKK 136
            E    E+K A  + +  +L  +   T L K + + + +       + +    L K DK 
Sbjct: 79  DEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138

Query: 137 TLVQE-DSADLKCQLHFAKEESALMCKKLTKLAKENDS-----------MKEELLKYRSL 184
           +  +E +   +K +L   +E  + +  +LT+   E  +           MK++L +    
Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198

Query: 185 YGDLDSALS---AEELA-DAPHSRETELKVHLKLVEEE-ANLLSRRIVELEVENRGLRAE 239
              L + LS   AE+ A      ++   +  ++L E+E   L+++  VE E++ + LR  
Sbjct: 199 ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQK-LRVL 257

Query: 240 MDDMKDHGGGCGG--PEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELED 297
              +++H     G      L    L   E    +  L + LQ +E E   LR +     +
Sbjct: 258 QRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQI--LSQQLQQMEAEHNTLRNTVETERE 315

Query: 298 QNKLLLNELAKFRSEHELDV-ALSEDSCSVLSEPSQEELAAAKLQ--IGELSGKVKKLQY 354
           ++K+LL ++    +E +L    L E+   +L +  Q   A A+L+     L  K K    
Sbjct: 316 ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME 375

Query: 355 ENRVLLSNLQR--------CDLASCQSTRPMLETDAEAGDSAQCV 391
           E    + +LQ+        CD    Q+++ + + + +A  SAQ +
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI 420



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 149/727 (20%), Positives = 271/727 (37%), Gaps = 121/727 (16%)

Query: 39   KAERRSLRA------AQTGQVDGELIRGLEQ-----DVKVSK-----DISMRLHKELE-- 80
            K E R LR+      ++  ++D ELI+  E       +K S+     ++ ++ +KELE  
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENK 2568

Query: 81   --VVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH---------SLKKRGTRS 129
               +E+K    EE NE+LR+     +  KQ L  E+E  +           +L++ GT  
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628

Query: 130  LGKADKKTLVQE----DSADLKCQLHFAKEESALMC---KKLTKLAKENDSMKEELLKYR 182
            L  A  K   +E     +     Q   A+ E  L+C   +   K+ +  D +K+EL    
Sbjct: 2629 LYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLH 2688

Query: 183  SLYGDLDSALSAEELADAPHSRE-TELKVHLKLVEEEANLLSRRIV-------------- 227
               G + +     E   A  +R+  E++  L +V +E   L+ +I               
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748

Query: 228  -------ELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGE-SLAELRR-HL 278
                   EL+ +      E+  +K+ G      +A L+ +A       E SL+ L + + 
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808

Query: 279  QFVEEEAELLRRSS----------------AELEDQNKLLLNELAKFRSEHELDVALSED 322
            Q + ++ +LL  SS                A L+++   L NEL KFR   E     +  
Sbjct: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQ 2868

Query: 323  SCSVLSEPSQEELAAAKLQ--IGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLET 380
              +  +E    + A + LQ     L  ++K LQ +   +   +        Q      +T
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928

Query: 381  DAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFT 440
             A      +     L   HE H +R+ ++        ++EQ  +     D  ++      
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988

Query: 441  AGLRLCLDNE---CADFRLHEAPDNSEGPRDT------------------KLIHAILVRL 479
              LR            ++   +P+ S  P  +                  K IH   +R+
Sbjct: 2989 RELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI 3048

Query: 480  SVLQQELNAFTRKADAV------LGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDF 533
              L    +    + + +         S++E Q+ +  L       L+   +L K +    
Sbjct: 3049 QQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL-------LNHCAVLEKQVQELQ 3101

Query: 534  QPPDFRDLPEWEPRIRE-AFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEA 592
              P   D+    P+ +    R  D +   +P +SF   + +  ++   E+ EL+ +L E 
Sbjct: 3102 AGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNT-RQEVNELRKLLEEE 3160

Query: 593  HDSLRGLQEQLS----QERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRL 648
             D     +  LS    Q R+L   E D+    ++     Q++ALL    +L S S +R  
Sbjct: 3161 RDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALL---IDLTSNSCRRTR 3217

Query: 649  EQKFWSQ 655
                W +
Sbjct: 3218 SGVGWKR 3224


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 183/946 (19%), Positives = 373/946 (39%), Gaps = 137/946 (14%)

Query: 13   VYQLQELRQQLD--QASKTCRILQYRLRKAERRSLRAA---QTGQVDGELIRGLEQDVKV 67
            ++++Q L++Q +  Q  K   IL Y   +     L+       G++  E     +Q    
Sbjct: 456  MFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASD 515

Query: 68   SKDISMRLHK---ELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKK 124
              ++  +L     E + + +   RL+ ENE+L        L++Q L  ELE   ++  +K
Sbjct: 516  VHELQQKLRTAFTEKDALLETVNRLQGENEKL--------LSQQELVPELENTIKNLQEK 567

Query: 125  RGTRSLGKADKKTLVQ----------EDSADLKCQLHFAKEES---ALMCKKLTKLAKEN 171
             G   L  + + T+++          E+  D   +L  + EE       C++  +L  E 
Sbjct: 568  NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 627

Query: 172  DSMKEELLKYRS--------LYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLS 223
                E+ ++Y S        L G L+  L  ++  D    +  +L V +K++ E+  +LS
Sbjct: 628  GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQND---QKLEKLMVQMKVLSEDKEVLS 684

Query: 224  RRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEE 283
              +  L  EN  L +E   +          +  +  S        E + +L + LQ + E
Sbjct: 685  AEVKSLYEENNKLSSEKKQL--------SRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736

Query: 284  EAELLRRSSAELEDQNKLLLNE-LAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQI 342
            E + L          NKLL NE + K   + +L   L E    V  +  ++++      +
Sbjct: 737  EQDNL----------NKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAV 786

Query: 343  GELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESH 402
            GE   K+            N ++C+LA  Q    +LE + E     +C+        +  
Sbjct: 787  GESLAKI------------NEEKCNLA-FQRDEKVLELEKE----IKCL--------QEE 821

Query: 403  AVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDN 462
            +V  C   ++ +L    ++  L+ K ++ + ++     + L            +  A + 
Sbjct: 822  SVVQCEELKS-LLRDYEQEKVLLRKELEEIQSEKEALQSDL----------LEMKNANEK 870

Query: 463  SEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKE 522
            +       LI    V  +  + E++    K      C +KE +     L     +    E
Sbjct: 871  TRLENQNLLIQVEEVSQTCSKSEIHNEKEK------CFIKEHENLKPLLEQKELRDRRAE 924

Query: 523  ILLAKDLGSDFQPPDFRDLP-----EWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDS 577
            ++L KD  S  + P  ++ P     E E +I    +  +   K +     +    +    
Sbjct: 925  LILLKD--SLAKSPSVKNDPLSSVKELEEKIENLEK--ECKEKEEKINKIKLVAVKAKKE 980

Query: 578  YASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRRE- 636
              S  KE Q V  E  +SLR  ++QLS   +   + A+++   +++ ++  ++  + +E 
Sbjct: 981  LDSSRKETQTVKEEL-ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKER 1039

Query: 637  ---FELQSLSLQRRLE------QKFWSQEKNML-----VQESQQFKHNFLLLFMKLRWFL 682
               FE +   L R+L       +   S  +++L     +Q + +     +L   + +  +
Sbjct: 1040 ANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMV 1099

Query: 683  KRWRQGKVLPSE---GDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEY 739
             +  + + L  E    +    VN ++EL + +++E+   Q +  +        Q T    
Sbjct: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159

Query: 740  IKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWET---ERAELKGHTSQMELKT 796
            ++ +AD +  +KEL   L ++   + +L+Q+    K   ET   E   L+    Q E K 
Sbjct: 1160 ME-IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN 1218

Query: 797  GKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQ----LQISERNWSQEKLQLV 852
             K          + A  ++ E    +L  S    +E ++Q     +I     + EK ++ 
Sbjct: 1219 TKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIH 1278

Query: 853  ERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWK 898
            E L+   +Q ++ +   Q R++ LQ+       + + +  +  S+K
Sbjct: 1279 EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYK 1324



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 173/881 (19%), Positives = 338/881 (38%), Gaps = 91/881 (10%)

Query: 61  LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTEL----ER 116
           L + +K   +    + K  E +EK R   EE+   L+++L  T   K+   T+L    E 
Sbjct: 166 LSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEA 225

Query: 117 PREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKE 176
             +H  K   +        K + QE+  +L CQ+  + +E      KL +L KEN  +K+
Sbjct: 226 NSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNEL-KEN-LVKQ 283

Query: 177 ELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEA---NLLSRRIVELEVEN 233
                +++    +  L  E L  A  +   + ++   L++E      +++ ++  LE   
Sbjct: 284 CEASEKNIQKKYECEL--ENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTL 341

Query: 234 RGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF--------VEEEA 285
           + L ++   +KD        + +L   A       +     R  L+F         EE+ 
Sbjct: 342 KELESQHSILKDEVTYMNNLKLKLEMDA---QHIKDEFFHEREDLEFKINELLLAKEEQG 398

Query: 286 ELLRRSSAELEDQNKLLL-------NELAKFRSEHELDVALSEDSCSVLSEPSQEELAAA 338
            ++ +  +EL   NK           E+   + +H+ ++  SE + + LS+  +E+L   
Sbjct: 399 CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEI--SELNETFLSDSEKEKL-TL 455

Query: 339 KLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGET 398
             +I  L  + + LQ E +  + N +     S +    +L+T  E G+SA      + + 
Sbjct: 456 MFEIQGLKEQCENLQQEKQEAILNYE-----SLREIMEILQT--ELGESA----GKISQE 504

Query: 399 HESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHE 458
            ES      + ++A  +  L+++        D L+   N         L  +     L  
Sbjct: 505 FES-----MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559

Query: 459 APDNSEGPRDTKLIHAIL--VRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGS 516
              N +      L+        L  L+ ++N+ T + D  +   +K   E   +      
Sbjct: 560 TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFIN-KLKNSHEEMDNF----H 614

Query: 517 QGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDND 576
           +   +E  L  +LG   +    +   E E ++ E   TG L+              + ND
Sbjct: 615 KKCEREERLILELGKKVE-QTIQYNSELEQKVNEL--TGGLEETLK--------EKDQND 663

Query: 577 SYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRRE 636
               ++     VL+E  + L    + L +E      E    ++ +      ++  +L+  
Sbjct: 664 QKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEH 723

Query: 637 FELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGD 696
                  LQ  +E++      N L++  Q  K   L +  +L  FLK         SE  
Sbjct: 724 ITQLEKKLQLMVEEQ---DNLNKLLENEQVQK---LFVKTQLYGFLKEMGSEVSEDSEEK 777

Query: 697 DFLEV-NSMKELYLLMEEEEIN-AQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKEL- 753
           D + V  ++ E    + EE+ N A   D K    +   +    E +    ++K  L++  
Sbjct: 778 DVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE 837

Query: 754 --CWLLRDERRGLTE----LQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD 807
               LLR E   +      LQ    + K   E  R E +    Q+E  +   +      +
Sbjct: 838 QEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNE 897

Query: 808 WKAALQREREEQQHLLAE----SYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVE 863
            +    +E E  + LL +       A + L +       +   + L  V+ L+ + + +E
Sbjct: 898 KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957

Query: 864 QQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
           ++ KE + ++++++  A   V    EL   D+S KET++ K
Sbjct: 958 KECKEKEEKINKIKLVA---VKAKKEL---DSSRKETQTVK 992



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 164/914 (17%), Positives = 353/914 (38%), Gaps = 142/914 (15%)

Query: 10   EEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSK 69
            +++  +L++L  Q+   S+   +L   ++     + + +   +   +L R LE  +   +
Sbjct: 660  DQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKK---QLSRDLEVFLSQKE 716

Query: 70   DISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRS 129
            D+ ++ H  +  +EKK   + EE + L + L   ++ K  ++T+L       LK+ G+  
Sbjct: 717  DVILKEH--ITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG----FLKEMGSEV 770

Query: 130  LGKADKKTLVQEDSA---------DLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK 180
               +++K +V    A         + KC L F ++E      K+ +L KE   ++EE   
Sbjct: 771  SEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE------KVLELEKEIKCLQEE--- 821

Query: 181  YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
                     S +  EEL           K  L+  E+E  LL + + E++ E   L++++
Sbjct: 822  ---------SVVQCEEL-----------KSLLRDYEQEKVLLRKELEEIQSEKEALQSDL 861

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGE-CGESLAELRRHLQFVEEEAELLRRSSAELEDQN 299
             +MK+           L        + C +S     +   F++E   L            
Sbjct: 862  LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENL------------ 909

Query: 300  KLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVL 359
            K LL +  K   +   ++ L +DS +       + L++ K    EL  K++ L+ E +  
Sbjct: 910  KPLLEQ--KELRDRRAELILLKDSLAKSPSVKNDPLSSVK----ELEEKIENLEKECKEK 963

Query: 360  LSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLR 419
               + +  L + ++ + +  +  E     + + +   E  +  A      + AE    L 
Sbjct: 964  EEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLL 1023

Query: 420  EQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRL 479
             +    S+ +DV    AN F   +   L  +  +  L     NS+          +L R+
Sbjct: 1024 LEYEKQSEQLDVEKERANNFEHRIE-DLTRQLRNSTLQCETINSDN-------EDLLARI 1075

Query: 480  SVLQQELNAFTRKADAVLGCSVKEQQESFSSL-PPLGSQGLSKEILLAKDLGSDFQPPDF 538
              LQ            +L   + E Q + + +   L ++ L KE  + +   +  +  + 
Sbjct: 1076 ETLQSNAK--------LLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEEL 1127

Query: 539  R-DLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLR 597
            +  L + + ++++  +  +L  K     +       D   Y   +KEL   L   ++ + 
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIAD---YERLMKELNQKLTNKNNKI- 1183

Query: 598  GLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEK 657
               E L QE +++K++ +   +++  L+   Q+    +  +++ L ++ + E        
Sbjct: 1184 ---EDLEQEIKIQKQKQETLQEEITSLQSSVQQ-YEEKNTKIKQLLVKTKKE-------- 1231

Query: 658  NMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEIN 717
               + +S+Q + + L+L   L+  L+  +Q                  E+Y +   E  +
Sbjct: 1232 ---LADSKQAETDHLILQASLKGELEASQQ----------------QVEVYKIQLAEITS 1272

Query: 718  AQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKAT 777
             +H                +E++KT A+           L   ++ +T LQ++   AKA 
Sbjct: 1273 EKHK--------------IHEHLKTSAEQHQR------TLSAYQQRVTALQEECRAAKAE 1312

Query: 778  WETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQL 837
              T  +E + +  ++     +   +          ++ERE  + L+ +    + +    L
Sbjct: 1313 QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372

Query: 838  QISE---RNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQD 894
            QI+    +    E   L+ER     Q+   +  EL+ +L  +Q        +H++   Q 
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL 1432

Query: 895  NSWKETRSEKIHDK 908
             S  E       D+
Sbjct: 1433 TSQNEVLRNSFRDQ 1446



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 184/978 (18%), Positives = 397/978 (40%), Gaps = 161/978 (16%)

Query: 56   ELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELA---KQVLQT 112
            EL + +EQ ++ + ++  ++++    +E+     ++ +++L + +++ ++    K+VL  
Sbjct: 626  ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 113  ELERPREHSLKKRGTRSLGKADKKT-LVQEDSADLKCQLHFAKEESALMCKKLTKLAK-- 169
            E++   E + K    +     D +  L Q++   LK  +   +++  LM ++   L K  
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745

Query: 170  ENDSMKEELLKYRSLYG---DLDSALSAE-ELADAPHSRETELKVHLKLVEEEANLLSRR 225
            EN+ +++  +K + LYG   ++ S +S + E  D  +  +   +   K+ EE+ NL  +R
Sbjct: 746  ENEQVQKLFVKTQ-LYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQR 804

Query: 226  ---IVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVE 282
               ++ELE E + L+ E                          +C     EL+  L+  E
Sbjct: 805  DEKVLELEKEIKCLQEE-----------------------SVVQC----EELKSLLRDYE 837

Query: 283  EEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQI 342
            +E  LLR+   E++ + + L ++L + ++ +E     +++    + E SQ     +K +I
Sbjct: 838  QEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ---TCSKSEI 894

Query: 343  GELSGKVKKLQYEN-RVLLSNLQRCD-------LASCQSTRPMLETDA-----EAGDSAQ 389
                 K    ++EN + LL   +  D       L    +  P ++ D      E  +  +
Sbjct: 895  HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954

Query: 390  CVPAPLGETHES-HAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLR-LCL 447
             +     E  E  + ++L   +  + L   R++   V + ++ L ++ +  +A +R L  
Sbjct: 955  NLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014

Query: 448  DNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQES 507
              E     L E    SE             +L V ++  N F  + + +     ++ + S
Sbjct: 1015 GAESYKNLLLEYEKQSE-------------QLDVEKERANNFEHRIEDL----TRQLRNS 1057

Query: 508  FSSLPPLGSQGLSKEILLAK--DLGSDFQPPDFRDLPEWEPRIREAFRTGDL-DSKPDPS 564
                  + S     E LLA+   L S+ +          E +I E  R   + D + +  
Sbjct: 1058 TLQCETINSDN---EDLLARIETLQSNAKL--------LEVQILEVQRAKAMVDKELEAE 1106

Query: 565  RSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQL------SQERQLRKEEADNFN 618
            +  +  + +++ +  +E++ELQ+ L +    L+   ++L      +Q+  L   E  ++ 
Sbjct: 1107 KLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYE 1166

Query: 619  QKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHN---FLLLF 675
            + M +L +       + E   Q + +Q++ +Q+   +E   L    QQ++        L 
Sbjct: 1167 RLMKELNQKLTNKNNKIEDLEQEIKIQKQ-KQETLQEEITSLQSSVQQYEEKNTKIKQLL 1225

Query: 676  MKLRWFLKRWRQGK----VLPSEGDDFLEVNSMK-ELYLLMEEEEINAQHSDNKAC-TGD 729
            +K +  L   +Q +    +L +     LE +  + E+Y +   E  + +H  ++   T  
Sbjct: 1226 VKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSA 1285

Query: 730  SWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTE------------LQQQFAKAKAT 777
               Q T + Y + +      L+E C   + E+  +T             L+QQ  K+ + 
Sbjct: 1286 EQHQRTLSAYQQRVT----ALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ 1341

Query: 778  WETERAE--------------LKGHTSQMELKTGKGAGERAGPDWKAALQRERE------ 817
             ETE A+              +K   SQ  L+      +    +    L+R  +      
Sbjct: 1342 AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETV 1401

Query: 818  ---------------EQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQV 862
                           E   + +E    V +LT Q ++   ++  +   L E  +   + +
Sbjct: 1402 SKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETL 1461

Query: 863  EQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIH--DKEAVSEVELGGNG 920
            +QQ+ +++ +L QL+   +P        ++   + +E R+  +   D   V+  E  G  
Sbjct: 1462 QQQLSKMEAQLFQLKN--EPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGME 1519

Query: 921  LKRTKSVSSMSEFESLLD 938
               T+SVSS S +   L+
Sbjct: 1520 TTDTESVSSASTYTQSLE 1537



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 69/371 (18%), Positives = 143/371 (38%), Gaps = 38/371 (10%)

Query: 2    LEMRDVYMEEDVYQLQELRQQLDQASKTCR---ILQYRLRKAERRSLRAAQTGQVDGELI 58
            LE   V ++++  QLQ+  Q+L+   K  +   ++   +   ER      Q        I
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183

Query: 59   RGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPR 118
              LEQ++K+ K     L +E+  ++    + EE+N +++Q L++T   K+ L    +   
Sbjct: 1184 EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKT---KKELADSKQAET 1240

Query: 119  EHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL 178
            +H + +                   A LK +L  ++++  +   +L ++  E   + E L
Sbjct: 1241 DHLILQ-------------------ASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHL 1281

Query: 179  LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRA 238
                       SA   +    A   R T L+   +  + E   ++      +V    +  
Sbjct: 1282 ---------KTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLK 1332

Query: 239  EMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQF-VEEEAELLRRSSAELED 297
            +  +         G +       +   +    L + + +LQ  V E   L       LE 
Sbjct: 1333 QQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLER 1392

Query: 298  QNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQ---EELAAAKLQIGELSGKVKKLQY 354
             NK+L   ++K     E   ++  ++  + SE +Q   +  +  ++       +V+ LQ 
Sbjct: 1393 HNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQE 1452

Query: 355  ENRVLLSNLQR 365
            E+R  +  LQ+
Sbjct: 1453 EHRKTVETLQQ 1463



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 88/389 (22%), Positives = 162/389 (41%), Gaps = 74/389 (19%)

Query: 578 YASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREF 637
           Y+ +   LQ  L EA ++   L EQL  +        +N    + +L+E+ ++  +R  F
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQ--------NNSEDNVKKLQEEIEK--IRPGF 194

Query: 638 ELQSLSLQRRLE------QKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVL 691
           E Q L LQ++L+      ++  +Q +N++   SQ ++ N   L  +L   LK   Q +V 
Sbjct: 195 EEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQ-LKAIHQEEVK 253

Query: 692 P-------SEGDDFLEVNSMKELYLLM----EEEEINAQ-----------------HSDN 723
                   S  +   E+N + EL   +    E  E N Q                 + DN
Sbjct: 254 ELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDN 313

Query: 724 KACT----GDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLT----ELQQQFAKAK 775
           + C+     +++ +   NE +K L D    L+    +L+DE   +     +L+      K
Sbjct: 314 QICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIK 373

Query: 776 ATWETERAELKGHTSQMEL-KTGKGA------GERAG--PDWKAALQREREEQQHLLAES 826
             +  ER +L+   +++ L K  +G        E AG    +   +++   E Q L  + 
Sbjct: 374 DEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQH 433

Query: 827 YSAVMELTRQ-LQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVL 885
              + EL    L  SE+    EKL L+  +QG K+Q E   +E Q  +   +   +   +
Sbjct: 434 QKEISELNETFLSDSEK----EKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489

Query: 886 KHSEL-------EKQDNSWKETRSEKIHD 907
             +EL        ++  S K+ ++  +H+
Sbjct: 490 LQTELGESAGKISQEFESMKQQQASDVHE 518


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 213/1033 (20%), Positives = 393/1033 (38%), Gaps = 200/1033 (19%)

Query: 16   LQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELI---RGLEQDV-KVSKDI 71
            L +  ++ DQ  K    L+ ++++   R   A    +++ EL    R LE +  ++ KDI
Sbjct: 899  LLDAEERCDQLIKAKFQLEAKIKEVTER---AEDEEEINAELTAKKRKLEDECSELKKDI 955

Query: 72   S------MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQT---------ELER 116
                    ++ KE    E K   L EE   L + + +    K+ LQ          + E 
Sbjct: 956  DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015

Query: 117  PREHSLKKRGTRSLGKAD--KKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSM 174
             + +SL K  ++   + +  + +L QE    +  + +  K E  L   + + L  END  
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075

Query: 175  K--EELLKYRSLYGDLDSALSAEELADAPHSRET-ELKVHLKLVEEEANLLSRRIVELEV 231
            +  E L K    Y  L S +  E+       ++  EL+  ++ +EEE         + E 
Sbjct: 1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEK 1135

Query: 232  ENRGLRAEMDDMKDHGGGCGG-----------------------PEARLAFSALGGG--- 265
            +      E++++ +     GG                        EA L   A+      
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK 1195

Query: 266  ECGESLAELRRHLQFVEEEAELLRRSSAELE---DQNKLLLNELAKFRSEHELDVALSED 322
            +  +S+AEL   +  ++   + L +  +E +   D     +  ++K ++  E      ED
Sbjct: 1196 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED 1255

Query: 323  SCSVLSEPSQE------ELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRP 376
              S     ++E      EL   K ++   +G++ +   E   ++S L R   A  Q T  
Sbjct: 1256 QLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEE 1315

Query: 377  MLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADA 436
            +     E   +   +   L  +   H   L R +  E   G  E    +SKA        
Sbjct: 1316 LKRQLEEENKAKNALAHALQSSR--HDCDLLREQYEEEQEGKAELQRALSKA-------- 1365

Query: 437  NGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILV-RLSVLQQELNAFTRKADA 495
                       ++E A +R     D  +   + +     L  RL   ++++ A   K  +
Sbjct: 1366 -----------NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414

Query: 496  VLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGS--DFQPPDF-RDLPEWEPRIREAF 552
            +     + Q E          + L  ++  A  L +  D +  +F + L EW+ +  E+ 
Sbjct: 1415 LEKTKQRLQGEV---------EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEES- 1464

Query: 553  RTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAE---AHDSLRGLQEQLSQE--- 606
               +L++    SRS      +  ++Y   + +L+ V  E       +  L EQ+++    
Sbjct: 1465 -QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523

Query: 607  --------RQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKN 658
                    +Q+  E+AD      +QL  ++  A L  E E + L +Q  L Q   S+   
Sbjct: 1524 IHELEKSRKQIELEKAD------IQLALEEAEAALEHE-EAKILRIQLELTQ-VKSEIDR 1575

Query: 659  MLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLL-------M 711
             + ++ ++ +             LKR  Q  V   +     EV S  E   L       +
Sbjct: 1576 KIAEKDEEIEQ------------LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623

Query: 712  EEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQF 771
             E EI   H++ +A            E +K L  ++  LK+    L D  RG  +L++Q 
Sbjct: 1624 NEIEIQLSHANRQAA-----------ETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL 1672

Query: 772  AKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAV- 830
            A  +      +AE++      EL+      ERA    +  L    E  Q L  ++ S + 
Sbjct: 1673 AIVERRANLLQAEVE------ELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIH 1726

Query: 831  ---------MELTRQLQISERNW--SQEKLQ--------LVERLQGE----------KQQ 861
                     M+L  +++ + R+   ++EK +        + E L+ E          K+ 
Sbjct: 1727 TKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1786

Query: 862  VEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGL 921
            +EQ VK+LQ+RL + ++ A    LK  + + Q     ETR  ++       E EL G   
Sbjct: 1787 LEQTVKDLQHRLDEAEQLA----LKGGKKQIQK---LETRIREL-------EFELEGEQK 1832

Query: 922  KRTKSVSSMSEFE 934
            K T+SV  + ++E
Sbjct: 1833 KNTESVKGLRKYE 1845



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 173/843 (20%), Positives = 335/843 (39%), Gaps = 94/843 (11%)

Query: 83   EKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQED 142
            EK+ A ++EE ++ +  L ++E  ++ L+ +L            T    K D +  VQ +
Sbjct: 847  EKEMATMKEEFQKTKDELAKSEAKRKELEEKLV-----------TLVQEKNDLQLQVQAE 895

Query: 143  SADL-----KC-QLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAE- 195
            S +L     +C QL  AK +     K++T+ A++ + +  EL   +    D  S L  + 
Sbjct: 896  SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955

Query: 196  ---ELADAPHSRE---TELKVHLKLVEEEANLLSRRIVELEVENRGL----RAEMDDMKD 245
               EL  A   +E   TE KV  K + EE + L   I +L  E + L    +  +DD++ 
Sbjct: 956  DDLELTLAKVEKEKHATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ- 1012

Query: 246  HGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNE 305
                    E ++        +  + + +L   L+  ++    L R+  +LE   KL    
Sbjct: 1013 ------AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066

Query: 306  LAKFRSE-HELDVALSE---DSCSVLSEPSQEELAAAKLQ--IGELSGKVKKLQYENRV- 358
            +    ++  +LD  L +   + C + S+   E+    + Q  I EL  ++++L+ E    
Sbjct: 1067 ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE 1126

Query: 359  ----LLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEV 414
                  +  QR D A  +    + E   EAG         L +  E+  ++L R  E   
Sbjct: 1127 RATRAKTEKQRSDYA--RELEELSERLEEAG-GVTSTQIELNKKREAEFLKLRRDLEEAT 1183

Query: 415  LPGLREQAALVSKAIDVL--VADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLI 472
            L      AAL  K  D +  + +       ++  L+ E ++F+L E  D S         
Sbjct: 1184 LQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-EIDDLSSSMESVSKS 1242

Query: 473  HAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSD 532
             A L ++    ++  +  R  +  +  S+ E     S L     + LS+++   + + S 
Sbjct: 1243 KANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE-LSRQLEEKESIVSQ 1301

Query: 533  F---------QPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIK 583
                      Q  + +   E E + + A       S+ D       Y  E          
Sbjct: 1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK-----A 1356

Query: 584  ELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLS 643
            ELQ  L++A+  +   + +   +   R EE +   +K+ Q  +D +  +     +  SL 
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL- 1415

Query: 644  LQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNS 703
               + +Q+   + ++++V + ++       L  K R F K   + K    E    LE + 
Sbjct: 1416 --EKTKQRLQGEVEDLMV-DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472

Query: 704  MKELYLLMEEEEINAQHSD--NKACTGDSWTQNTPNE---YIKTLADMKVTLKELCWLLR 758
             +   L  E  ++   + +  ++  T     +N   E     + +A+   T+ EL     
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL----- 1527

Query: 759  DERRGLTELQQ---QFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQRE 815
            ++ R   EL++   Q A  +A    E  E K    Q+EL   K   +R     K A   E
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR-----KIA---E 1579

Query: 816  REEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQ 875
            ++E+   L  +Y   +E  +    +E     E ++L ++++G+  ++E Q+     + ++
Sbjct: 1580 KDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE 1639

Query: 876  LQK 878
              K
Sbjct: 1640 TLK 1642



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 68/300 (22%), Positives = 132/300 (44%), Gaps = 27/300 (9%)

Query: 58   IRGLEQDVKVSKDISMR----LHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTE 113
            ++G  +D ++  D ++R    L ++L +VE++   L+ E EELR  L +TE A+++ + E
Sbjct: 1647 VQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQE 1706

Query: 114  LERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDS 173
            L    E  ++   T++      K  ++ D   L+ ++  A  ++    +K  K   +   
Sbjct: 1707 LLDSNER-VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAM 1765

Query: 174  MKEELLKYRSLYGDLDSALS--AEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEV 231
            M EEL K +     L+       + + D  H  +   ++ LK  +++   L  RI ELE 
Sbjct: 1766 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825

Query: 232  ENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRS 291
            E   L  E     +   G    E R+        E  +++  L+  +  ++ + +  +R 
Sbjct: 1826 E---LEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQ 1882

Query: 292  SAELEDQNKLLLNELAKFR-SEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVK 350
            + E ++Q       L KFR ++HEL             E ++E    A+ Q+ +L  K +
Sbjct: 1883 AEEADEQANA---HLTKFRKAQHEL-------------EEAEERADIAESQVNKLRAKTR 1926



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 79/362 (21%), Positives = 140/362 (38%), Gaps = 65/362 (17%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMR 74
            ++ +L +Q+ +  KT   L+   ++ E   L  A       E    LE +      I + 
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIE---LEKADIQLALEEAEAALEHEEAKILRIQLE 1565

Query: 75   LHKELEVVEKKRARLEEENEELR---QRLIETELAKQVLQTELERPREHSLKKRGTRSLG 131
            L +    +++K A  +EE E+L+   QR +ET   +  L  E+ R R  +++        
Sbjct: 1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVET--MQSALDAEV-RSRNEAIR-------- 1614

Query: 132  KADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSA 191
                K  ++ D  +++ QL  A  ++A   K L  +  +        LK   L+  LD A
Sbjct: 1615 ---LKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ--------LKDTQLH--LDDA 1661

Query: 192  LSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVE----LEVENRGLRAEMDDMKDHG 247
            L  +E          +LK  L +VE  ANLL   + E    LE   R  +    ++ D  
Sbjct: 1662 LRGQE----------DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD-- 1709

Query: 248  GGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELA 307
                    R+            +  +L   L  ++ E E   R +   E++ K  + + A
Sbjct: 1710 -----SNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAA 1764

Query: 308  KFRSEHELDVALS--------------EDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQ 353
                E + +   S              +D    L E  Q  L   K QI +L  ++++L+
Sbjct: 1765 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE 1824

Query: 354  YE 355
            +E
Sbjct: 1825 FE 1826



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 195/958 (20%), Positives = 372/958 (38%), Gaps = 181/958 (18%)

Query: 15   QLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTG---------QVDGELIRG----- 60
            Q+++L   L+Q  K    L+   RK E   L+ AQ           Q+D  L +      
Sbjct: 1031 QVEDLESSLEQEKKLRVDLERNKRKLEG-DLKLAQESILDLENDKQQLDERLKKKDFEYC 1089

Query: 61   -LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPRE 119
             L+  V+  + + ++  K+++ ++ +   LEEE E  R    +TE  +     ELE   E
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE 1149

Query: 120  HSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTK--------LAKEN 171
              L++ G  +  + +     + +   L+  L  A  +   M   L K        L ++ 
Sbjct: 1150 R-LEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI 1208

Query: 172  DSM---KEELLKYRSLY----GDLDSALSA----------------EELADAPHSRE--- 205
            D++   K++L K +S +     DL S++ +                ++L++A    E   
Sbjct: 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268

Query: 206  ---TELKVHLKLVEEEANLLSRRIVE-------LEVENRGLRAEMDDMKDHGGGCGGPEA 255
               +EL      ++ EA  LSR++ E       L    +    + +++K         E 
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ-----LEEE 1323

Query: 256  RLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHEL 315
              A +AL       +L   R     + E+ E  +   AEL+       +E+A++R+++E 
Sbjct: 1324 NKAKNAL-----AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1378

Query: 316  DVALSEDSCSVLS-------EPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRC-- 366
            D     +             + S+E++ A   +   L    ++LQ E   L+ +++R   
Sbjct: 1379 DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438

Query: 367  -----DLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREA--EVLPGLR 419
                 D       + + E   +  +S   + A L E+  S +  L + + A  E L  L 
Sbjct: 1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES-RSLSTELFKLKNAYEEALDQL- 1496

Query: 420  EQAALVSKAIDVLVAD------ANGFT----AGLRLCLDNECADFRLHEAPDNSEGPRDT 469
            E     +K ++  +AD       NG T       R  ++ E AD +L      +    + 
Sbjct: 1497 ETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEE 1556

Query: 470  KLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQ---ESFSSLPPLGSQGLSKEILLA 526
              I  I + L+ ++ E++    + D  +    +  Q   E+  S      +  ++ I L 
Sbjct: 1557 AKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLK 1616

Query: 527  KDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQ 586
            K +          DL E E ++  A R          + + +  R     S   ++K+ Q
Sbjct: 1617 KKMEG--------DLNEIEIQLSHANR--------QAAETLKHLR-----SVQGQLKDTQ 1655

Query: 587  LVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQR 646
            L L    D+LRG QE L ++  + +  A+     ++Q + ++ RA L +    + L+ Q 
Sbjct: 1656 LHL---DDALRG-QEDLKEQLAIVERRAN-----LLQAEVEELRATLEQTERARKLAEQE 1706

Query: 647  RLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKE 706
             L+    S E+  L+        N  L+  K           K L +   D +++ S  E
Sbjct: 1707 LLD----SNERVQLLH-----TQNTSLIHTK-----------KKLET---DLMQLQSEVE 1743

Query: 707  LYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTE 766
                   +  NA+    KA T  +       +   T A ++   K L   ++D +  L E
Sbjct: 1744 ---DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1800

Query: 767  LQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAES 826
             +Q   K     + ++ E +    + EL+     GE          Q++  E    L + 
Sbjct: 1801 AEQLALKG-GKKQIQKLETRIRELEFELE-----GE----------QKKNTESVKGLRKY 1844

Query: 827  YSAVMELTRQLQISERNWSQ-----EKLQLVERLQGEKQQVEQQVKELQNRLSQLQKA 879
               V ELT Q +   +N  +     +KLQ+  +++  K+Q E+  ++    L++ +KA
Sbjct: 1845 ERRVKELTYQSEEDRKNVLRLQDLVDKLQV--KVKSYKRQAEEADEQANAHLTKFRKA 1900


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 203/957 (21%), Positives = 374/957 (39%), Gaps = 161/957 (16%)

Query: 14   YQLQELRQQLDQASKTCRILQYRLRK-AERRSLRAAQTGQVDGELIRGLEQDVKVSKDIS 72
            ++L++L +  D +  + +   + L + A  R L+  +  Q     I+GL     V ++  
Sbjct: 434  WELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESG 493

Query: 73   MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQT---ELERPREHSLKKRGTRS 129
            ++  +    +EK+  +L ++ E+L+ +L   + + Q L+T   EL R +E       T  
Sbjct: 494  LKCGE----LEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549

Query: 130  LGKADKKTLVQEDSADLKCQLHFAKEESALMCK-KLTKLAKENDSMKEEL---------- 178
              KA +   ++++   L   +   +E S +  + ++  + KEN ++ + +          
Sbjct: 550  ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQL 609

Query: 179  -LKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELE------- 230
              + R L+ DL+ A    E A+       +L+  L+ ++EE   L+R++  LE       
Sbjct: 610  EFEKRQLHRDLEQAKEKGERAE-------KLERELQRLQEENGRLARKVTSLETATEKVE 662

Query: 231  ----------VENRGLRAEMDDMKDHGGGCGGPEA---RLAFSALGGGECGESLAELRRH 277
                      +ENR LR  +D +++      G E    +L    L      E++      
Sbjct: 663  ALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTK 722

Query: 278  LQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAA 337
            L  +E E + L R   EL  +N  LL  L K +SE    + LS  S S  +   Q+ L +
Sbjct: 723  LAQMERENQQLEREKEELR-KNVDLLKALGK-KSER---LELSYQSVSAENLRLQQSLES 777

Query: 338  AKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGE 397
            +  +   L  ++ +L+ E + L  +L+   LA+ Q      +  A   + AQ       +
Sbjct: 778  SSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDK--K 835

Query: 398  THESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLH 457
              E  A RL +  + E+   + + +     A++    ++      L  C D   A  +L 
Sbjct: 836  LLEKEAKRLWQ--QVELKDAVLDDSTAKLSAVE---KESRALDKELARCRD---AAGKLK 887

Query: 458  EAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQ 517
            E   ++        +HA    L+ L+++L     K+  +     K  QE       L   
Sbjct: 888  ELEKDNRDLTKQVTVHART--LTTLREDLVLEKLKSQQLSSELDKLSQE-------LEKV 938

Query: 518  GLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDS 577
            GL++E+LL +D                             DS  D        R E    
Sbjct: 939  GLNRELLLQED-----------------------------DSGSDTKYKILEGRNESALK 969

Query: 578  YASEIKELQLVLAEAH-DSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQR------ 630
                +KE ++VL EA  +    L  QL  E Q+ K+E +   Q   + +  Q        
Sbjct: 970  TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG 1029

Query: 631  ---------------------ALLR---REFELQSLSLQRRLEQKFWSQEKNMLVQESQQ 666
                                  LLR   R  EL+  +   + E++   ++   L  ++  
Sbjct: 1030 KTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVT 1089

Query: 667  FKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKA- 725
            F    L L  K   FL+          E +  L+  + K   L +E   +++Q +   A 
Sbjct: 1090 FSSQILTL-QKQSAFLQ----------EHNTTLQTQTAK---LQVENSTLSSQSAALTAQ 1135

Query: 726  ---CTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETER 782
                      + T NE ++   +      E   LL+D     T  ++Q A+ +A    + 
Sbjct: 1136 YTLLQNHHTAKETENESLQRQQEQLTAAYEA--LLQDHEHLGTLHERQSAEYEALIR-QH 1192

Query: 783  AELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVME--LTRQLQIS 840
            + LK     +EL+  K  GER G   K   + E EE++ +L     A+ +   T  L + 
Sbjct: 1193 SCLKTLHRNLELEH-KELGERHGDMLKR--KAELEEREKVLTTEREALQQEQRTNALAMG 1249

Query: 841  ERNWSQEKLQLVE----RLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
            E    + +L  V     +L+GE +++    KEL+  L+  Q   + W  +  EL++Q
Sbjct: 1250 ENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 212/997 (21%), Positives = 410/997 (41%), Gaps = 145/997 (14%)

Query: 9    MEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRA-AQTGQVDGELIRGLEQDVKV 67
            +E+   QL + R ++DQ      +L+ +  K E   L A A++ +   + +  L +    
Sbjct: 270  LEDKTEQLVDTRHEVDQL-----VLELQKVKQENIQLAADARSARAYRDELDSLREKANR 324

Query: 68   SKDISMRLHK---ELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKK 124
             + + + L +   +L  V+  +AR+EE  E+    LIET   K +L+ +L          
Sbjct: 325  VERLELELTRCKEKLHDVDFYKARMEELRED-NIILIET---KAMLEEQL---------- 370

Query: 125  RGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKEN----DSMKEELLK 180
              T +  + DK   +++++  LK +LH  + +     K++ +L +EN     + K+ + +
Sbjct: 371  --TAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428

Query: 181  YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240
               L  +L+      +L+DA  SR++        V E     S RI++LE EN+ L++ +
Sbjct: 429  SAHLGWELEQLSKNADLSDA--SRKS-------FVFELNECASSRILKLEKENQSLQSTI 479

Query: 241  DDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNK 300
              ++D           L  S L  GE  +   +L + ++ ++ + E  ++S+ +LE  ++
Sbjct: 480  QGLRD-------ASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSE 532

Query: 301  LLLNELAKFRSEHELDVALSEDSCSVLSEPSQEE--LAAAKLQIGELS-----GKVKKLQ 353
             L+ E  + +S+ E    L  D    + +  QE+  L  A   + E S      ++K ++
Sbjct: 533  ELIREKEQLQSDME---TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE 589

Query: 354  YENRVLLSNLQRCD--LASCQSTRPMLETD----AEAGDSAQCVPAPLGETHESHAVRLC 407
             EN+ L   +   +  L+  +  +  L  D     E G+ A+ +   L    E +  RL 
Sbjct: 590  KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG-RLA 648

Query: 408  R--------AREAEVL----PGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFR 455
            R          + E L     GL+ +   + K++D L          + L L+    D +
Sbjct: 649  RKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTL--------QNVSLQLEGLERDNK 700

Query: 456  LHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLG 515
              +A +N E  R  + +     +L+ +++E     R+ +        E +++   L  LG
Sbjct: 701  QLDA-ENLELRRLVETMRFTSTKLAQMERENQQLEREKE--------ELRKNVDLLKALG 751

Query: 516  SQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDN 575
             +    E+         +Q     +L   +     + +T  L+S+     + R  +A   
Sbjct: 752  KKSERLEL--------SYQSVSAENLRLQQSLESSSHKTQTLESELGELEAER--QALRR 801

Query: 576  DSYASEIKELQLVLAEA-HDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKE---DQQRA 631
            D  A  +   QL  AE    +L     QL ++++L ++EA    Q+ V+LK+   D   A
Sbjct: 802  DLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ-VELKDAVLDDSTA 860

Query: 632  LLRREFELQSLSLQRRLEQ------KFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRW 685
             L    E +S +L + L +      K    EK+      Q   H   L  ++    L++ 
Sbjct: 861  KL-SAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKL 919

Query: 686  RQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLAD 745
            +  + L SE D        +EL  +    E+  Q  D+ + T     +      +KT   
Sbjct: 920  K-SQQLSSELDKL-----SQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLA 973

Query: 746  MKVTLKELCWLLRDERRGLT-ELQQQFAKAKATWETERA-ELKGHTSQMELK--TGKGAG 801
            MK     L     +E+  L  +L+ +    K   ET R  + +G   Q   K   GK A 
Sbjct: 974  MKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAA 1033

Query: 802  ERAGPD-W-----KAALQREREEQQHLLAESYSAVMELTRQ--------LQISERNWSQE 847
               G + W     +A ++  R + + +  E  +A ++  +Q        L+     +S +
Sbjct: 1034 SHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQ 1093

Query: 848  KLQLVER---LQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEK 904
             L L ++   LQ     ++ Q  +LQ   S L   +     +++ L+    + KET +E 
Sbjct: 1094 ILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTA-KETENES 1152

Query: 905  IHDKE----AVSEVELGGNGLKRTKSVSSMSEFESLL 937
            +  ++    A  E  L  +    T      +E+E+L+
Sbjct: 1153 LQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALI 1189



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 229/1063 (21%), Positives = 387/1063 (36%), Gaps = 207/1063 (19%)

Query: 15   QLQELRQQLDQASKTCRIL--------QYRLRKAERRSLRAAQT-GQVDGELI------R 59
            Q+++L Q+ D  ++    L        + R++  E+ +    QT  + +G+L       R
Sbjct: 555  QIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKR 614

Query: 60   GLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPRE 119
             L +D++ +K+   R  K    +E++  RL+EEN  L +++   E A + ++      + 
Sbjct: 615  QLHRDLEQAKEKGERAEK----LERELQRLQEENGRLARKVTSLETATEKVEALEHESQG 670

Query: 120  HSLKKRGTR-SLGKADKKTL----VQEDSADLKCQ---LHFAKEESALMCKKLTKLAKEN 171
              L+ R  R SL      +L    ++ D+  L  +   L    E       KL ++ +EN
Sbjct: 671  LQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMEREN 730

Query: 172  DSM---KEELLKYRSLYGDLDSALSAEELADAPHSRET-ELKVHLKLVEEEANLLSRRIV 227
              +   KEEL K   L   L       EL+    S E   L+  L+    +   L   + 
Sbjct: 731  QQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELG 790

Query: 228  ELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAEL 287
            ELE E + LR +++ +            RLA + L G E                ++ + 
Sbjct: 791  ELEAERQALRRDLEAL------------RLANAQLEGAE----------------KDRKA 822

Query: 288  LRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSG 347
            L +  A+LE   KLL  E  +   + EL  A+ +DS                      + 
Sbjct: 823  LEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDS----------------------TA 860

Query: 348  KVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLC 407
            K+  ++ E+R L   L RC  A+ +    + E + +  D  + V          HA  L 
Sbjct: 861  KLSAVEKESRALDKELARCRDAAGK----LKELEKDNRDLTKQVTV--------HARTLT 908

Query: 408  RAREAEVLPGLREQAALVSKAIDVLVADAN--GFTAGLRLCLDNECADFRLHEAPDNSEG 465
              RE  VL  L+ Q   +S  +D L  +    G    L L  D+  +D +       +E 
Sbjct: 909  TLREDLVLEKLKSQQ--LSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNES 966

Query: 466  PRDTKLI--HAILVRLSVLQQELNAFTRKADAVLGCSVKE-------------QQESFSS 510
               T L      +V L    +E  +  R+ ++ L    KE              Q SF  
Sbjct: 967  ALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKH 1026

Query: 511  LPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD-LDSKPDPSRSFRP 569
              P G    S +    K+           +L   + R  E  R    L ++    +    
Sbjct: 1027 --PAGKTAASHQ---GKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQ 1081

Query: 570  YRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQ 629
            +    N +++S+I  LQ   A   +    LQ Q +      K + +N            Q
Sbjct: 1082 HLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTA------KLQVENSTLSSQSAALTAQ 1135

Query: 630  RALLRREF---ELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWR 686
              LL+      E ++ SLQR+ EQ   + E  +   E     H                R
Sbjct: 1136 YTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHE---------------R 1180

Query: 687  QGKVLPSEGDDFLEVNS-MKELY--LLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTL 743
            Q     +E +  +  +S +K L+  L +E +E+  +H D                    +
Sbjct: 1181 QS----AEYEALIRQHSCLKTLHRNLELEHKELGERHGD--------------------M 1216

Query: 744  ADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERA------------ELKG---- 787
               K  L+E   +L  ER  L   Q+Q   A A  E +R             +LKG    
Sbjct: 1217 LKRKAELEEREKVLTTEREALQ--QEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEE 1274

Query: 788  -HTSQMELKTGKGAGERAGPDWKAALQREREEQQ-------------HLLAESYSAVMEL 833
             H    ELKT     +     W+A     +E+ Q              LL+     + E 
Sbjct: 1275 LHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE 1334

Query: 834  TRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQ 893
               L    +  SQ+   L+E+    K+Q  ++ K+  ++L+ L++  +    K  +  K 
Sbjct: 1335 NHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKF 1394

Query: 894  DNSWKETRSEKIHDKEAVSEVELGGNGLK-RTKSV--SSMSEFESLLDCSPYLAGGDARG 950
             +   + ++  I  K  V  ++    G + R KS   S   + ES    SP  +      
Sbjct: 1395 YDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQ 1454

Query: 951  KKLPNNPAFGFVSSEPGDPEKDTKEK-PG--LSSRDCNHLGAL 990
             + P+ PA G   +E  D    +  K PG     R   H G+L
Sbjct: 1455 AENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSL 1497



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 67/343 (19%), Positives = 143/343 (41%), Gaps = 33/343 (9%)

Query: 2    LEMRDVYMEEDVYQLQELRQQ---LDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELI 58
            +E++D  +++   +L  + ++   LD+    CR    +L++ E+ +    +   V    +
Sbjct: 848  VELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL 907

Query: 59   RGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPR 118
              L +D+ + K  S +L  EL+ + ++  ++    E L Q   E +         LE   
Sbjct: 908  TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQ---EDDSGSDTKYKILEGRN 964

Query: 119  EHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEEL 178
            E +LK     +L   ++K ++ E   + K  L+   E    M KK  +  ++N    + L
Sbjct: 965  ESALK----TTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHL 1020

Query: 179  L-KYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLR 237
               ++   G   ++   +E     H   T   + +K           R +ELE  N  L+
Sbjct: 1021 QNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVK----------DRAIELERNNAALQ 1070

Query: 238  AEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELED 297
            AE   +K+          +L             +  L++   F++E    L+  +A+L+ 
Sbjct: 1071 AEKQLLKE----------QLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQV 1120

Query: 298  QNKLLLNELAKFRSEHEL--DVALSEDSCSVLSEPSQEELAAA 338
            +N  L ++ A   +++ L  +   ++++ +   +  QE+L AA
Sbjct: 1121 ENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAA 1163


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,163,022
Number of Sequences: 37866
Number of extensions: 1869823
Number of successful extensions: 15832
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 798
Number of HSP's that attempted gapping in prelim test: 8482
Number of HSP's gapped (non-prelim): 5415
length of query: 1016
length of database: 18,247,518
effective HSP length: 112
effective length of query: 904
effective length of database: 14,006,526
effective search space: 12661899504
effective search space used: 12661899504
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.