Search of human proteins with 61744435

Search of human proteins with 61744435

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
         (875 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]            1764   0.0  
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]            1661   0.0  
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]            1655   0.0  
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]           595   e-170
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]           518   e-146
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]           455   e-128
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]           410   e-114
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]            406   e-113
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]            406   e-113
gi|170650674 phosphodiesterase 6A [Homo sapiens]                      393   e-109
gi|157364939 phosphodiesterase 6C [Homo sapiens]                      377   e-104
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]             342   1e-93
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]           342   1e-93
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]            312   1e-84
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]            288   2e-77
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]            288   2e-77
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]              288   2e-77
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]      138   2e-32
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]      138   2e-32
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]      138   2e-32
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]             137   4e-32
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]             137   4e-32
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]             137   4e-32
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]             137   4e-32
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]             137   4e-32
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]             137   4e-32
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]             137   4e-32
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]             137   4e-32
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]             137   4e-32
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]             137   4e-32

>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
          Length = 875

 Score = 1764 bits (4569), Expect = 0.0
 Identities = 875/875 (100%), Positives = 875/875 (100%)

Query: 1   MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE 60
           MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
Sbjct: 1   MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE 60

Query: 61  RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG 120
           RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
Sbjct: 61  RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG 120

Query: 121 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI 180
           TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
Sbjct: 121 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI 180

Query: 181 SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL 240
           SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
Sbjct: 181 SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL 240

Query: 241 NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE 300
           NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
Sbjct: 241 NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE 300

Query: 301 KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS 360
           KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
Sbjct: 301 KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS 360

Query: 361 FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME 420
           FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
Sbjct: 361 FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME 420

Query: 421 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 480
           PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
Sbjct: 421 PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 480

Query: 481 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL 540
           VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
Sbjct: 481 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL 540

Query: 541 QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL 600
           QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
Sbjct: 541 QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL 600

Query: 601 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 660
           SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
Sbjct: 601 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 660

Query: 661 NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI 720
           NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
Sbjct: 661 NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI 720

Query: 721 LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE 780
           LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
Sbjct: 721 LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE 780

Query: 781 LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF 840
           LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
Sbjct: 781 LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF 840

Query: 841 PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 875
           PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
Sbjct: 841 PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 875


>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
          Length = 833

 Score = 1661 bits (4301), Expect = 0.0
 Identities = 826/826 (100%), Positives = 826/826 (100%)

Query: 50  TREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRP 109
           TREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRP
Sbjct: 8   TREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRP 67

Query: 110 LRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALC 169
           LRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALC
Sbjct: 68  LRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALC 127

Query: 170 HKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGI 229
           HKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGI
Sbjct: 128 HKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGI 187

Query: 230 VGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKS 289
           VGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKS
Sbjct: 188 VGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKS 247

Query: 290 GNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEV 349
           GNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEV
Sbjct: 248 GNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEV 307

Query: 350 ILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINY 409
           ILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINY
Sbjct: 308 ILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINY 367

Query: 410 MYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQ 469
           MYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQ
Sbjct: 368 MYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQ 427

Query: 470 LVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYH 529
           LVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYH
Sbjct: 428 LVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYH 487

Query: 530 ASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQ 589
           ASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQ
Sbjct: 488 ASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQ 547

Query: 590 MKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIA 649
           MKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIA
Sbjct: 548 MKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIA 607

Query: 650 ALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEY 709
           ALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEY
Sbjct: 608 ALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEY 667

Query: 710 KTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAIT 769
           KTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAIT
Sbjct: 668 KTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAIT 727

Query: 770 KPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLY 829
           KPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLY
Sbjct: 728 KPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLY 787

Query: 830 EALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 875
           EALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
Sbjct: 788 EALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 833


>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
          Length = 823

 Score = 1655 bits (4286), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 53  MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRP 112
           MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRP
Sbjct: 1   MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRP 60

Query: 113 IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKI 172
           IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKI
Sbjct: 61  IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKI 120

Query: 173 FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH 232
           FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH
Sbjct: 121 FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH 180

Query: 233 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 292
           VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG
Sbjct: 181 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 240

Query: 293 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILK 352
           GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILK
Sbjct: 241 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILK 300

Query: 353 KIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYA 412
           KIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYA
Sbjct: 301 KIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYA 360

Query: 413 QYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVN 472
           QYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVN
Sbjct: 361 QYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVN 420

Query: 473 KMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASA 532
           KMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASA
Sbjct: 421 KMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASA 480

Query: 533 AEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKH 592
           AEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKH
Sbjct: 481 AEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKH 540

Query: 593 EVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALS 652
           EVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALS
Sbjct: 541 EVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALS 600

Query: 653 HDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTT 712
           HDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTT
Sbjct: 601 HDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTT 660

Query: 713 LKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPW 772
           LKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPW
Sbjct: 661 LKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPW 720

Query: 773 PIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 832
           PIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL
Sbjct: 721 PIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 780

Query: 833 THVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 875
           THVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
Sbjct: 781 THVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 823


>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
          Length = 933

 Score =  595 bits (1535), Expect = e-170
 Identities = 317/721 (43%), Positives = 468/721 (64%), Gaps = 27/721 (3%)

Query: 153 LELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGST 212
           LELVKDIS+ LD+T+L +KI + +  ++ ADR SLFLV   ++  K L+S+ FDV  G+ 
Sbjct: 206 LELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTP 265

Query: 213 LEEVSN----NCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 268
           L   S+    N +++ W KGI+G+V   GE +NI DAY+D RFN E+D++TGYKT+S+LC
Sbjct: 266 LLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLC 325

Query: 269 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 328
           MPI++   E++GVAQAINK    G  FTE DEK    YL FCGI + NAQL+  S  E +
Sbjct: 326 MPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384

Query: 329 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM 386
           R++ LL++ + +FEEQ  LE I+KKI     + ++ ++C++ ++++  S    F+  F +
Sbjct: 385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFEL 444

Query: 387 ECEELEKSSDTLTREHDANK------INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENT 440
              +    ++   +E           IN   A+ V +T  P+NI D  +D RF    +  
Sbjct: 445 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 504

Query: 441 GNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCG 500
              +   IRS+LC PI N   +++IGV Q++N+++      KPF+  D++  EAFVIFCG
Sbjct: 505 SGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCG 555

Query: 501 LGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFS 560
           LGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E  + +   AA +P    L I D  
Sbjct: 556 LGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIH 612

Query: 561 FSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN 620
           F DF L         +RMF +L +VQ F++ +E LCRW+L+V+KNYR  V YHNWRHAFN
Sbjct: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFN 671

Query: 621 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI 680
             Q MFA L     Q+ LT++EILA+++  L HDLDHRG NN++  +S   LAQLY  S 
Sbjct: 672 VCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSA 731

Query: 681 -MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI 739
            +EHHHF+  +MIL S G+ I + LS +EY   ++++KQ+ILATDL LY +RR EFFEL+
Sbjct: 732 TLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELV 791

Query: 740 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI 799
            K +++    + +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL +
Sbjct: 792 SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKL 851

Query: 800 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
            P+ + +R +K+++P +Q+ +ID+IC+ LY+AL  V+    P+LD    NR KW+ L ++
Sbjct: 852 TPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911

Query: 860 Q 860
           +
Sbjct: 912 R 912


>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
          Length = 683

 Score =  518 bits (1333), Expect = e-146
 Identities = 272/623 (43%), Positives = 403/623 (64%), Gaps = 23/623 (3%)

Query: 247 EDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAY 306
           +D RFN E+D++TGYKT+S+LCMPI++   E++GVAQAINK    G  FTE DEK    Y
Sbjct: 54  KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMY 112

Query: 307 LAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQK 366
           L FCGI + NAQL+  S  E +R++ LL++ + +FEEQ  LE I+KKI     + ++ ++
Sbjct: 113 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 172

Query: 367 CTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKNT 418
           C++ ++++  S    F+  F +   +    ++   +E           IN   A+ V +T
Sbjct: 173 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 232

Query: 419 MEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENT 478
             P+NI D  +D RF    +     +   IRS+LC PI N   +++IGV Q++N+++   
Sbjct: 233 GLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-- 286

Query: 479 GKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR 538
              KPF+  D++  EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E  
Sbjct: 287 ---KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 343

Query: 539 ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRW 598
           + +   AA +P    L I D  F DF L         +RMF +L +VQ F++ +E LCRW
Sbjct: 344 KFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 400

Query: 599 ILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR 658
           +L+V+KNYR  V YHNWRHAFN  Q MFA L     Q+ LT++EILA+++  L HDLDHR
Sbjct: 401 LLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHR 459

Query: 659 GVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIK 717
           G NN++  +S   LAQLY  S  +EHHHF+  +MIL S G+ I + LS +EY   ++++K
Sbjct: 460 GTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLK 519

Query: 718 QAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQR 777
           Q+ILATDL LY +RR EFFEL+ K +++    + +++F +MLMTACDL A+TKPW I ++
Sbjct: 520 QSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQ 579

Query: 778 IAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSE 837
           +AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL  V+ 
Sbjct: 580 VAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNV 639

Query: 838 DCFPLLDGCRKNRQKWQALAEQQ 860
              P+LD    NR KW+ L +++
Sbjct: 640 KLKPMLDSVATNRSKWEELHQKR 662



 Score =  107 bits (268), Expect = 4e-23
 Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)

Query: 145 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 203
           E ++   LLE+V D+     D+  +  KI      L+  +R S+ L+ ED  +     ++
Sbjct: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 190

Query: 204 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 253
            F++        AE S  E +  +    +W  N  I   VA+ G P+NI DAY+DPRF+A
Sbjct: 191 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 249

Query: 254 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 313
           E DQI+G+  +S+LC+PI N   +++GVAQ +N+  G    F + D++ F A++ FCG+ 
Sbjct: 250 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 307

Query: 314 LHNAQLYETSLLENKRNQVLLDLAS 338
           ++N  +Y+       +  V LD+ S
Sbjct: 308 INNTIMYDQVKKSWAKQSVALDVLS 332


>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
          Length = 575

 Score =  455 bits (1170), Expect = e-128
 Identities = 239/564 (42%), Positives = 360/564 (63%), Gaps = 22/564 (3%)

Query: 306 YLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQ 365
           YL FCGI + NAQL+  S  E +R++ LL++ + +FEEQ  LE I+KKI     + ++ +
Sbjct: 4   YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63

Query: 366 KCTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKN 417
           +C++ ++++  S    F+  F +   +    ++   +E           IN   A+ V +
Sbjct: 64  RCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAS 123

Query: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
           T  P+NI D  +D RF    +     +   IRS+LC PI N   +++IGV Q++N+++  
Sbjct: 124 TGLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG- 178

Query: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
               KPF+  D++  EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E 
Sbjct: 179 ----KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEV 234

Query: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
            + +   AA +P    L I D  F DF L         +RMF +L +VQ F++ +E LCR
Sbjct: 235 DKFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCR 291

Query: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDH 657
           W+L+V+KNYR  V YHNWRHAFN  Q MFA L     Q+ LT++EILA+++  L HDLDH
Sbjct: 292 WLLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDH 350

Query: 658 RGVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKII 716
           RG NN++  +S   LAQLY  S  +EHHHF+  +MIL S G+ I + LS +EY   ++++
Sbjct: 351 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 410

Query: 717 KQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQ 776
           KQ+ILATDL LY +RR EFFEL+ K +++    + +++F +MLMTACDL A+TKPW I +
Sbjct: 411 KQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISR 470

Query: 777 RIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVS 836
           ++AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL  V+
Sbjct: 471 QVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVN 530

Query: 837 EDCFPLLDGCRKNRQKWQALAEQQ 860
               P+LD    NR KW+ L +++
Sbjct: 531 VKLKPMLDSVATNRSKWEELHQKR 554



 Score =  107 bits (268), Expect = 4e-23
 Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)

Query: 145 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 203
           E ++   LLE+V D+     D+  +  KI      L+  +R S+ L+ ED  +     ++
Sbjct: 24  EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 82

Query: 204 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 253
            F++        AE S  E +  +    +W  N  I   VA+ G P+NI DAY+DPRF+A
Sbjct: 83  SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 141

Query: 254 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 313
           E DQI+G+  +S+LC+PI N   +++GVAQ +N+  G    F + D++ F A++ FCG+ 
Sbjct: 142 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 199

Query: 314 LHNAQLYETSLLENKRNQVLLDLAS 338
           ++N  +Y+       +  V LD+ S
Sbjct: 200 INNTIMYDQVKKSWAKQSVALDVLS 224



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 4/63 (6%)

Query: 492 LEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSA 551
           ++ ++ FCG+ I N Q++ A  +   +    LEV++      EE+T +L+ +   ++  A
Sbjct: 1   MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN---DLFEEQT-DLEKIVKKIMHRA 56

Query: 552 QTL 554
           QTL
Sbjct: 57  QTL 59


>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
          Length = 489

 Score =  410 bits (1054), Expect = e-114
 Identities = 214/473 (45%), Positives = 310/473 (65%), Gaps = 20/473 (4%)

Query: 389 EELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCI 448
           E +EKSS      +    IN   A+ V +T  P+NI D  +D RF    +     +   I
Sbjct: 15  ESMEKSS------YSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFH---I 65

Query: 449 RSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQM 508
           RS+LC PI N   +++IGV Q++N+++      KPF+  D++  EAFVIFCGLGI NT M
Sbjct: 66  RSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCGLGINNTIM 119

Query: 509 YEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSD 568
           Y+ V+++ AKQ V L+VLSYHA+ ++ E  + +   AA +P    L I D  F DF L  
Sbjct: 120 YDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIHFDDFSLDV 176

Query: 569 LETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAA 628
                  +RMF +L +VQ F++ +E LCRW+L+V+KNYR  V YHNWRHAFN  Q MFA 
Sbjct: 177 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFNVCQLMFAM 235

Query: 629 LKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI-MEHHHFD 687
           L     Q+ LT++EILA+++  L HDLDHRG NN++  +S   LAQLY  S  +EHHHF+
Sbjct: 236 LTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFN 295

Query: 688 QCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLE 747
             +MIL S G+ I + LS +EY   ++++KQ+ILATDL LY +RR EFFEL+ K +++  
Sbjct: 296 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 355

Query: 748 DPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNR 807
             + +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL + P+ + +R
Sbjct: 356 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 415

Query: 808 EKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ 860
            +K+++P +Q+ +ID+IC+ LY+AL  V+    P+LD    NR KW+ L +++
Sbjct: 416 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKR 468



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 51/133 (38%), Positives = 80/133 (60%), Gaps = 5/133 (3%)

Query: 208 AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQS 265
           AE S  E +  +    +W  N  I   VA+ G P+NI DAY+DPRF+AE DQI+G+  +S
Sbjct: 9   AENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 67

Query: 266 ILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLL 325
           +LC+PI N   +++GVAQ +N+  G    F + D++ F A++ FCG+ ++N  +Y+    
Sbjct: 68  VLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLGINNTIMYDQVKK 125

Query: 326 ENKRNQVLLDLAS 338
              +  V LD+ S
Sbjct: 126 SWAKQSVALDVLS 138


>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
          Length = 853

 Score =  406 bits (1044), Expect = e-113
 Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)

Query: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
           ++ + LLELV+D+   +++  +  K+   +  L+ ADR SLF+  + +   + L +RLF 
Sbjct: 54  EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112

Query: 207 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 263
           V   S LE+     ++ I    + G+VGHVA   + +N++D  E P F++  D++T YKT
Sbjct: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172

Query: 264 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 323
           +++L  PI N ++ VV V  A+NK   NG  FT +DE  F  YL F  + L   ++Y  S
Sbjct: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226

Query: 324 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 380
            L N   +R QVLL  A+ +FEE   +E    K   T+ +++  ++ ++ ++D      F
Sbjct: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286

Query: 381 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 413
             V+ +   E +  S   T +              H   +I  +                
Sbjct: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346

Query: 414 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 473
           YV  +    NI + S D+ F +  E   + +   I+++L  PI N KK +++GV    N+
Sbjct: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404

Query: 474 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 533
            +      KPF+  DE  +E+   F G  + NT  Y+ + +   ++ +  +++ YH    
Sbjct: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459

Query: 534 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 574
            +E +                   EL  +    +P   T  I +F FSD E ++L+   C
Sbjct: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519

Query: 575 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 634
            I+M+ +L +V+ FQ+  EVL R++ S+ K YR+ + YHNWRH FN AQ MF  L  GK+
Sbjct: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578

Query: 635 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 694
           ++  TDLE  A++ A L HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L+
Sbjct: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638

Query: 695 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 750
                I   L+  +++  + ++  AI+ATDLALY K+R  F +++ +++ N +D      
Sbjct: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697

Query: 751 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 803
                  +KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L+ +P  
Sbjct: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757

Query: 804 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
           +M+R K  ++P +QVGFID +C  +Y+  +   E+  P+ D  + NR++W+ALA++ E
Sbjct: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)

Query: 324 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 381
           L + + +  LL+L   + +E  ++E ++ K+   + + +Q  +C++F+  +    ++  +
Sbjct: 50  LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108

Query: 382 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 441
            +F ++ + + +             ++     +V  T + +N+ DV++   F   +    
Sbjct: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165

Query: 442 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 474
            +     +++L TPI NGK   V+ V   VNK+
Sbjct: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196


>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
          Length = 854

 Score =  406 bits (1044), Expect = e-113
 Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)

Query: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
           ++ + LLELV+D+   +++  +  K+   +  L+ ADR SLF+  + +   + L +RLF 
Sbjct: 54  EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112

Query: 207 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 263
           V   S LE+     ++ I    + G+VGHVA   + +N++D  E P F++  D++T YKT
Sbjct: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172

Query: 264 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 323
           +++L  PI N ++ VV V  A+NK   NG  FT +DE  F  YL F  + L   ++Y  S
Sbjct: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226

Query: 324 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 380
            L N   +R QVLL  A+ +FEE   +E    K   T+ +++  ++ ++ ++D      F
Sbjct: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286

Query: 381 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 413
             V+ +   E +  S   T +              H   +I  +                
Sbjct: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346

Query: 414 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 473
           YV  +    NI + S D+ F +  E   + +   I+++L  PI N KK +++GV    N+
Sbjct: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404

Query: 474 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 533
            +      KPF+  DE  +E+   F G  + NT  Y+ + +   ++ +  +++ YH    
Sbjct: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459

Query: 534 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 574
            +E +                   EL  +    +P   T  I +F FSD E ++L+   C
Sbjct: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519

Query: 575 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 634
            I+M+ +L +V+ FQ+  EVL R++ S+ K YR+ + YHNWRH FN AQ MF  L  GK+
Sbjct: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578

Query: 635 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 694
           ++  TDLE  A++ A L HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L+
Sbjct: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638

Query: 695 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 750
                I   L+  +++  + ++  AI+ATDLALY K+R  F +++ +++ N +D      
Sbjct: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697

Query: 751 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 803
                  +KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L+ +P  
Sbjct: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757

Query: 804 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
           +M+R K  ++P +QVGFID +C  +Y+  +   E+  P+ D  + NR++W+ALA++ E
Sbjct: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)

Query: 324 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 381
           L + + +  LL+L   + +E  ++E ++ K+   + + +Q  +C++F+  +    ++  +
Sbjct: 50  LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108

Query: 382 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 441
            +F ++ + + +             ++     +V  T + +N+ DV++   F   +    
Sbjct: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165

Query: 442 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 474
            +     +++L TPI NGK   V+ V   VNK+
Sbjct: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196


>gi|170650674 phosphodiesterase 6A [Homo sapiens]
          Length = 860

 Score =  393 bits (1010), Expect = e-109
 Identities = 251/785 (31%), Positives = 406/785 (51%), Gaps = 74/785 (9%)

Query: 152 LLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGS 211
           + +L++D   +L        +   +  L+ ADR SLF+     +    L +RLF+V + +
Sbjct: 61  IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMY-RTRNGIAELATRLFNVHKDA 119

Query: 212 TLEE---VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 268
            LE+   + +  I    + GIVGHVA   +  N+ +  ED  F   VD +T YKT++IL 
Sbjct: 120 VLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILA 179

Query: 269 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 328
            PI N ++ VV +  A+NK  G+   FT++DE+    YL F  +++    L      E +
Sbjct: 180 SPIMNGKD-VVAIIMAVNKVDGSH--FTKRDEEILLKYLNFANLIMKVYHLSYLHNCETR 236

Query: 329 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMEC 388
           R Q+LL   S +FEE   +E    K   T+ +F+   + ++ ++D      F  V+ +  
Sbjct: 237 RGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLM 296

Query: 389 EELEKSSDTLTREHDANKIN-YMYAQYVKNTMEPLN-IPDVSKD-----KRFPWTTENTG 441
            E+   S    R  D  +IN Y    Y+ +  E +  IP+   D        P      G
Sbjct: 297 GEVPPYSGP--RTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNG 354

Query: 442 NV---------------------NQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 480
            +                     +   I+++L  PI N KK +++GV    N+ +     
Sbjct: 355 LICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVN-KKEEIVGVATFYNRKDG---- 409

Query: 481 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-- 538
            KPF+  DE  +E+   F G  + N   YE++ +   ++ +  +++ YH     EE +  
Sbjct: 410 -KPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKI 468

Query: 539 -----------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTD 581
                            EL  +  A +P A   +I  F FSD  L++LE   C I+M+ +
Sbjct: 469 LKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYE 528

Query: 582 LNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDL 641
           L +V  F +  E L R++ S+ K YRK + YHNWRH FN  Q MF+ L  GK++   TDL
Sbjct: 529 LKVVDKFHIPQEALVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587

Query: 642 EILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQIL 701
           E LA++ AA  HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L      I 
Sbjct: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIF 647

Query: 702 SGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN----------QFNLEDPHQ 751
             L+  +++  + ++  AI+ATDLALY K+R  F +++ ++          Q+ + +  +
Sbjct: 648 QNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTR 707

Query: 752 KELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKN 811
           KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L   P  +M+R K +
Sbjct: 708 KEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKAD 767

Query: 812 KIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE-KMLINGESG 870
           ++P +QVGFID +C  +Y+  +   E+  P+LDG   NR++W+ALA++ + KM +  E  
Sbjct: 768 ELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827

Query: 871 QAKRN 875
           Q +++
Sbjct: 828 QKQQS 832


>gi|157364939 phosphodiesterase 6C [Homo sapiens]
          Length = 858

 Score =  377 bits (968), Expect = e-104
 Identities = 255/825 (30%), Positives = 419/825 (50%), Gaps = 97/825 (11%)

Query: 106 FDRPLRPIVVKDSEGTVSFLSDSEKKEQMPL-TPPRFDH----DEGDQCSRLLELVKDIS 160
           FDR LR          V  L +  K  Q+P+ +   F      +E   C  LL  V++  
Sbjct: 24  FDRKLR----------VEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEG 73

Query: 161 SHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEV---S 217
              +     H+    +  L+ ADR S+FL C   +    + SRL DV   S  E+     
Sbjct: 74  GTPEQGV--HRALQRLAHLLQADRCSMFL-CRSRNGIPEVASRLLDVTPTSKFEDNLVGP 130

Query: 218 NNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREE 277
           +  +    + GIVG  A   +  N+ D  ++  F+  +D+ TGY T+++L  PI   +E 
Sbjct: 131 DKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKE- 189

Query: 278 VVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVL---HNAQLYETSLLENKRNQVLL 334
           V+ V  A+NK   N   F+++DE+ F+ YL F  I+L   H + +Y    +E++R+Q+L+
Sbjct: 190 VLAVIMAVNKV--NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYN---IESRRSQILM 244

Query: 335 DLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKS 394
             A+ +FEE   +E    K   T+ S++  ++ +I ++D      F   + ++  E+E  
Sbjct: 245 WSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPY 304

Query: 395 SDTLTREHDANKIN-YMYAQYVKNTMEPLNI---------------PDVSKDKRF----- 433
               T   D  ++N Y    Y+ +  E + +               P    +  F     
Sbjct: 305 KGPKTP--DGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMM 362

Query: 434 -----PWTTENTGNVNQQ--CIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNR 486
                 + T   G V++    I+++L  PI N KK  ++GV    N+ +      KPF+ 
Sbjct: 363 NAPADEYFTFQKGPVDETGWVIKNVLSLPIVN-KKEDIVGVATFYNRKDG-----KPFDE 416

Query: 487 NDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-------- 538
           +DE   E    F G  + NT  Y+ + +   ++ +  E+L     A  EE +        
Sbjct: 417 HDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEK 476

Query: 539 ------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ 586
                       +L ++    +P  ++ ++ +F FSDF L++     C IR+F ++N+V+
Sbjct: 477 LNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVE 536

Query: 587 NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILAL 646
            F++  EVL RW+ +V+K YR  V YHNWRH FN  Q MF  L  G+++   TDLE  A+
Sbjct: 537 KFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAM 595

Query: 647 LIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSI 706
           L AA  HD+DHRG NN Y  +S  PLA+L+  SI+E HH +    +L      I   L+ 
Sbjct: 596 LAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNK 655

Query: 707 EEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK-NQFNLE---------DPHQKELFL 756
            +++T + + + AI+ATDLALY K+R  F +++    Q   E         DP +KE+ +
Sbjct: 656 RQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIM 715

Query: 757 AMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSM 816
           AM+MTACDLSAITKPW +Q ++A +VA EF++QGD ER  L  +P  +M+R K++++P +
Sbjct: 716 AMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKL 775

Query: 817 QVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
           QVGFID +C  +Y+  +   ++  P+L G + NR +W++LA++ +
Sbjct: 776 QVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYD 820


>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
          Length = 779

 Score =  342 bits (876), Expect = 1e-93
 Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)

Query: 229 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 288
           +  +VA   + L ++D   D RF       +G + QS+LC+PI     +++G+ +    +
Sbjct: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 208

Query: 289 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 348
                 F    ++   A LA+  + +H  Q+      + + N  LLD++   F+   +++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268

Query: 349 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 408
            +L+ I     + +   +C +F VD    + +S +F +  E+  K     T+E   + I 
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 327

Query: 409 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 467
              A  V  T E LNIPD   D RF    +  TG       R++LC PI +  +  VIGV
Sbjct: 328 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 381

Query: 468 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 527
            Q+VNK+  +      F++ DE   + F +FC L +    MY  +  +     VT+E LS
Sbjct: 382 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436

Query: 528 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 587
           YH+    EE    Q L    +P     +I  F F   ++   E     I ++        
Sbjct: 437 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 490

Query: 588 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 647
              + E LCR+I+SVKKNYR+ V YHNW+HA   A CM+A L+        TDLE   LL
Sbjct: 491 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 547

Query: 648 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 707
           IA L HDLDHRG +NSY+Q+ +HPLA LY  S ME HHF Q + IL   G+ I S LS  
Sbjct: 548 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 607

Query: 708 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 767
           EY+  L+II++AI+ATDLALY   R +  E+ +    NL +   ++  + ++MTACDL +
Sbjct: 608 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 667

Query: 768 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 827
           +TK WP+ +  A  +  EF+ +GD E K+L I+P  +M+R+KK+++P  Q+GF +A+ + 
Sbjct: 668 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 726

Query: 828 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
            Y  LT +     PLL  CR N  +W+ +   +E
Sbjct: 727 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 760



 Score =  118 bits (296), Expect = 2e-26
 Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)

Query: 165 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 222
           + +L   I ++   L++ADR +LF V      +K L S LFD+ E    + V      IR
Sbjct: 267 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 323

Query: 223 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 282
               KGI G VA  GE LNI DAY DPRFN EVD  TGY T++ILCMPI + R  V+GV 
Sbjct: 324 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 382

Query: 283 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 320
           Q +NK SG+   F++ DE +F  +  FC + LH A +Y
Sbjct: 383 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 418


>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
          Length = 789

 Score =  342 bits (876), Expect = 1e-93
 Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)

Query: 229 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 288
           +  +VA   + L ++D   D RF       +G + QS+LC+PI     +++G+ +    +
Sbjct: 161 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 218

Query: 289 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 348
                 F    ++   A LA+  + +H  Q+      + + N  LLD++   F+   +++
Sbjct: 219 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 278

Query: 349 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 408
            +L+ I     + +   +C +F VD    + +S +F +  E+  K     T+E   + I 
Sbjct: 279 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 337

Query: 409 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 467
              A  V  T E LNIPD   D RF    +  TG       R++LC PI +  +  VIGV
Sbjct: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 391

Query: 468 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 527
            Q+VNK+  +      F++ DE   + F +FC L +    MY  +  +     VT+E LS
Sbjct: 392 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446

Query: 528 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 587
           YH+    EE    Q L    +P     +I  F F   ++   E     I ++        
Sbjct: 447 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 500

Query: 588 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 647
              + E LCR+I+SVKKNYR+ V YHNW+HA   A CM+A L+        TDLE   LL
Sbjct: 501 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 557

Query: 648 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 707
           IA L HDLDHRG +NSY+Q+ +HPLA LY  S ME HHF Q + IL   G+ I S LS  
Sbjct: 558 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 617

Query: 708 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 767
           EY+  L+II++AI+ATDLALY   R +  E+ +    NL +   ++  + ++MTACDL +
Sbjct: 618 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 677

Query: 768 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 827
           +TK WP+ +  A  +  EF+ +GD E K+L I+P  +M+R+KK+++P  Q+GF +A+ + 
Sbjct: 678 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 736

Query: 828 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
            Y  LT +     PLL  CR N  +W+ +   +E
Sbjct: 737 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 770



 Score =  118 bits (296), Expect = 2e-26
 Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)

Query: 165 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 222
           + +L   I ++   L++ADR +LF V      +K L S LFD+ E    + V      IR
Sbjct: 277 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 333

Query: 223 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 282
               KGI G VA  GE LNI DAY DPRFN EVD  TGY T++ILCMPI + R  V+GV 
Sbjct: 334 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 392

Query: 283 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 320
           Q +NK SG+   F++ DE +F  +  FC + LH A +Y
Sbjct: 393 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 428


>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
          Length = 575

 Score =  312 bits (799), Expect = 1e-84
 Identities = 169/478 (35%), Positives = 274/478 (57%), Gaps = 39/478 (8%)

Query: 414 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 473
           YV  +    NI + S D+ F +  E   + +   I+++L  PI N KK +++GV    N+
Sbjct: 68  YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 125

Query: 474 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 533
            +      KPF+  DE  +E+   F G  + NT  Y+ + +   ++ +  +++ YH    
Sbjct: 126 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180

Query: 534 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 574
            +E +                   EL  +    +P   T  I +F FSD E ++L+   C
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240

Query: 575 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 634
            I+M+ +L +V+ FQ+  EVL R++ S+ K YR+ + YHNWRH FN AQ MF  L  GK+
Sbjct: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 299

Query: 635 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 694
           ++  TDLE  A++ A L HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L+
Sbjct: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359

Query: 695 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 750
                I   L+  +++  + ++  AI+ATDLALY K+R  F +++ +++ N +D      
Sbjct: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 418

Query: 751 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 803
                  +KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L+ +P  
Sbjct: 419 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 478

Query: 804 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
           +M+R K  ++P +QVGFID +C  +Y+  +   E+  P+ D  + NR++W+ALA++ E
Sbjct: 479 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 536



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 5/106 (4%)

Query: 228 GIVGHVAALGEPLNIKDAYEDPRFNAEVDQI--TGYKTQSILCMPIKNHREEVVGVAQAI 285
           G+  +VA  G   NI +A  D  F  +   +  +G+  +++L MPI N +EE+VGVA   
Sbjct: 64  GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123

Query: 286 NKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYE-TSLLENKRN 330
           N+K G    F E+DE    +   F G  + N   Y+  + LEN+++
Sbjct: 124 NRKDGK--PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKD 167


>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
          Length = 932

 Score =  288 bits (737), Expect = 2e-77
 Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)

Query: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
           D+  ++L+L  ++   LD ++L  K+  ++     A R  L LV ED  N +     + D
Sbjct: 216 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 272

Query: 207 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 265
              G   EEVS          G +G V    + + +KD   ED +   ++  + G + Q+
Sbjct: 273 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 320

Query: 266 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 324
           +LC+P I    ++VV +A A NK  G+   FT++DE        +   VL +   ++   
Sbjct: 321 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 378

Query: 325 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 384
                 Q LL +A  +F     + V+L++I     +    + C++F++D++  +  + VF
Sbjct: 379 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 436

Query: 385 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 444
                + E     +  +          A +V  T + LNIPD      F    +++    
Sbjct: 437 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 489

Query: 445 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 504
               R++LC PIKN +  +VIGV +LVNK+         F++ DE    AF I+CG+ I 
Sbjct: 490 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 540

Query: 505 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 563
           ++ +Y+ V  A  +  +  E++ YH   +++E  +L  L   + P +A       F+++ 
Sbjct: 541 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 598

Query: 564 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 623
             L + +T++  + M  D+N + N+++    L R+ L VKK YR +  YHNW HAF+ + 
Sbjct: 599 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 657

Query: 624 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 681
             +   K  ++ N L D+EI AL I+ + HDLDHRG NNS+   S+  LA LY    S+M
Sbjct: 658 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 717

Query: 682 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 741
           E HHF Q + ILN+ G  I    S ++Y+  L +++  ILATDLA ++ R  +  + + +
Sbjct: 718 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 776

Query: 742 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 801
             ++  +     L L +LMT+CDLS  TK W   ++IAEL+  EFF QGD E K +   P
Sbjct: 777 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 835

Query: 802 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
            ++M+REK   IP +Q+ F++ I + +Y+ L  +      L +    NR+ W  ++ +
Sbjct: 836 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 892


>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
          Length = 934

 Score =  288 bits (737), Expect = 2e-77
 Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)

Query: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
           D+  ++L+L  ++   LD ++L  K+  ++     A R  L LV ED  N +     + D
Sbjct: 218 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 274

Query: 207 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 265
              G   EEVS          G +G V    + + +KD   ED +   ++  + G + Q+
Sbjct: 275 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 322

Query: 266 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 324
           +LC+P I    ++VV +A A NK  G+   FT++DE        +   VL +   ++   
Sbjct: 323 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 380

Query: 325 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 384
                 Q LL +A  +F     + V+L++I     +    + C++F++D++  +  + VF
Sbjct: 381 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 438

Query: 385 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 444
                + E     +  +          A +V  T + LNIPD      F    +++    
Sbjct: 439 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 491

Query: 445 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 504
               R++LC PIKN +  +VIGV +LVNK+         F++ DE    AF I+CG+ I 
Sbjct: 492 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 542

Query: 505 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 563
           ++ +Y+ V  A  +  +  E++ YH   +++E  +L  L   + P +A       F+++ 
Sbjct: 543 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 600

Query: 564 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 623
             L + +T++  + M  D+N + N+++    L R+ L VKK YR +  YHNW HAF+ + 
Sbjct: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 659

Query: 624 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 681
             +   K  ++ N L D+EI AL I+ + HDLDHRG NNS+   S+  LA LY    S+M
Sbjct: 660 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 719

Query: 682 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 741
           E HHF Q + ILN+ G  I    S ++Y+  L +++  ILATDLA ++ R  +  + + +
Sbjct: 720 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 778

Query: 742 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 801
             ++  +     L L +LMT+CDLS  TK W   ++IAEL+  EFF QGD E K +   P
Sbjct: 779 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 837

Query: 802 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
            ++M+REK   IP +Q+ F++ I + +Y+ L  +      L +    NR+ W  ++ +
Sbjct: 838 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 894


>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
          Length = 941

 Score =  288 bits (737), Expect = 2e-77
 Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)

Query: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
           D+  ++L+L  ++   LD ++L  K+  ++     A R  L LV ED  N +     + D
Sbjct: 225 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 281

Query: 207 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 265
              G   EEVS          G +G V    + + +KD   ED +   ++  + G + Q+
Sbjct: 282 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 329

Query: 266 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 324
           +LC+P I    ++VV +A A NK  G+   FT++DE        +   VL +   ++   
Sbjct: 330 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 387

Query: 325 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 384
                 Q LL +A  +F     + V+L++I     +    + C++F++D++  +  + VF
Sbjct: 388 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 445

Query: 385 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 444
                + E     +  +          A +V  T + LNIPD      F    +++    
Sbjct: 446 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 498

Query: 445 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 504
               R++LC PIKN +  +VIGV +LVNK+         F++ DE    AF I+CG+ I 
Sbjct: 499 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 549

Query: 505 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 563
           ++ +Y+ V  A  +  +  E++ YH   +++E  +L  L   + P +A       F+++ 
Sbjct: 550 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 607

Query: 564 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 623
             L + +T++  + M  D+N + N+++    L R+ L VKK YR +  YHNW HAF+ + 
Sbjct: 608 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 666

Query: 624 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 681
             +   K  ++ N L D+EI AL I+ + HDLDHRG NNS+   S+  LA LY    S+M
Sbjct: 667 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 726

Query: 682 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 741
           E HHF Q + ILN+ G  I    S ++Y+  L +++  ILATDLA ++ R  +  + + +
Sbjct: 727 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 785

Query: 742 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 801
             ++  +     L L +LMT+CDLS  TK W   ++IAEL+  EFF QGD E K +   P
Sbjct: 786 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 844

Query: 802 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
            ++M+REK   IP +Q+ F++ I + +Y+ L  +      L +    NR+ W  ++ +
Sbjct: 845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 901


>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
          Length = 606

 Score =  138 bits (348), Expect = 2e-32
 Identities = 111/397 (27%), Positives = 188/397 (47%), Gaps = 39/397 (9%)

Query: 507 QMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQ---------SLAAAVVPS------- 550
           Q+ E + R    Q   +E+    A  A +    +          SL++A VP        
Sbjct: 151 QVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQ 210

Query: 551 ----AQTLKITD-FSFSDFELSDLE-----TALCTIRMFTDLNLVQNFQMKHEVLCRWIL 600
               A+ L+ T+ +    F++++L      TA+    +F + +L++ FQ+  + L  ++L
Sbjct: 211 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAII-FSIFQERDLLKTFQIPADTLATYLL 269

Query: 601 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 660
            ++ +Y  NVAYHN  HA + AQ     L    ++   TDLEILA L A+  HD+DH GV
Sbjct: 270 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 329

Query: 661 NNSYIQRSEHPLAQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQA 719
           +N ++  +   LA +Y   S++E+HH      +L +    I   LS ++  +  +++   
Sbjct: 330 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 389

Query: 720 ILATDLALYIKRRGEFFELIRKNQFN------LEDPHQKELFLAMLMTACDLSAITKPWP 773
           +LATD++ ++    +   ++   +        L++   +   L  L+   DLS  TKP P
Sbjct: 390 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 449

Query: 774 IQQRIAELVATEFFDQGDRERKE-LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 832
           + ++  + +  EFF QGDRER+  L+I P   M  +    +   QVGFID I   L+E  
Sbjct: 450 LYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWETW 506

Query: 833 TH-VSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGE 868
              V  D   LLD    NR+ +Q+   +    L N E
Sbjct: 507 ADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 543


>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
          Length = 680

 Score =  138 bits (348), Expect = 2e-32
 Identities = 111/397 (27%), Positives = 188/397 (47%), Gaps = 39/397 (9%)

Query: 507 QMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQ---------SLAAAVVPS------- 550
           Q+ E + R    Q   +E+    A  A +    +          SL++A VP        
Sbjct: 225 QVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQ 284

Query: 551 ----AQTLKITD-FSFSDFELSDLE-----TALCTIRMFTDLNLVQNFQMKHEVLCRWIL 600
               A+ L+ T+ +    F++++L      TA+    +F + +L++ FQ+  + L  ++L
Sbjct: 285 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAII-FSIFQERDLLKTFQIPADTLATYLL 343

Query: 601 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 660
            ++ +Y  NVAYHN  HA + AQ     L    ++   TDLEILA L A+  HD+DH GV
Sbjct: 344 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 403

Query: 661 NNSYIQRSEHPLAQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQA 719
           +N ++  +   LA +Y   S++E+HH      +L +    I   LS ++  +  +++   
Sbjct: 404 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 463

Query: 720 ILATDLALYIKRRGEFFELIRKNQFN------LEDPHQKELFLAMLMTACDLSAITKPWP 773
           +LATD++ ++    +   ++   +        L++   +   L  L+   DLS  TKP P
Sbjct: 464 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 523

Query: 774 IQQRIAELVATEFFDQGDRERKE-LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 832
           + ++  + +  EFF QGDRER+  L+I P   M  +    +   QVGFID I   L+E  
Sbjct: 524 LYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWETW 580

Query: 833 TH-VSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGE 868
              V  D   LLD    NR+ +Q+   +    L N E
Sbjct: 581 ADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 617


>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
          Length = 712

 Score =  138 bits (348), Expect = 2e-32
 Identities = 111/397 (27%), Positives = 188/397 (47%), Gaps = 39/397 (9%)

Query: 507 QMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQ---------SLAAAVVPS------- 550
           Q+ E + R    Q   +E+    A  A +    +          SL++A VP        
Sbjct: 257 QVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQ 316

Query: 551 ----AQTLKITD-FSFSDFELSDLE-----TALCTIRMFTDLNLVQNFQMKHEVLCRWIL 600
               A+ L+ T+ +    F++++L      TA+    +F + +L++ FQ+  + L  ++L
Sbjct: 317 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAII-FSIFQERDLLKTFQIPADTLATYLL 375

Query: 601 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 660
            ++ +Y  NVAYHN  HA + AQ     L    ++   TDLEILA L A+  HD+DH GV
Sbjct: 376 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 435

Query: 661 NNSYIQRSEHPLAQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQA 719
           +N ++  +   LA +Y   S++E+HH      +L +    I   LS ++  +  +++   
Sbjct: 436 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 495

Query: 720 ILATDLALYIKRRGEFFELIRKNQFN------LEDPHQKELFLAMLMTACDLSAITKPWP 773
           +LATD++ ++    +   ++   +        L++   +   L  L+   DLS  TKP P
Sbjct: 496 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 555

Query: 774 IQQRIAELVATEFFDQGDRERKE-LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 832
           + ++  + +  EFF QGDRER+  L+I P   M  +    +   QVGFID I   L+E  
Sbjct: 556 LYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWETW 612

Query: 833 TH-VSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGE 868
              V  D   LLD    NR+ +Q+   +    L N E
Sbjct: 613 ADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 649


>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 63  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 121

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 122 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 181

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 182 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 239

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 240 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 298

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 299 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 329


>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 63  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 121

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 122 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 181

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 182 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 239

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 240 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 298

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 299 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 329


>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
          Length = 567

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 244 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 302

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 303 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 362

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 363 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 420

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 421 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 479

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 480 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 510


>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
          Length = 552

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 229 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 287

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 288 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 347

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 348 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 405

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 406 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 464

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 465 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 495


>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
          Length = 526

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 203 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 261

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 262 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 321

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 322 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 379

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 380 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 438

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 439 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 469


>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
          Length = 376

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 53  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 111

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 112 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 171

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 172 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 229

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 230 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 288

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 289 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 319


>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 63  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 121

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 122 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 181

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 182 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 239

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 240 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 298

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 299 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 329


>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
          Length = 491

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 168 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 226

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 227 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 286

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 287 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 344

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 345 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 403

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 404 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 434


>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
          Length = 459

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 136 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 194

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 195 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 254

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 255 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 312

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 313 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 371

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 372 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 402


>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
          Length = 376

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)

Query: 570 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 629
           E   C   M+ DL LV++F +    L RW+  V  NYR N  +HN+RH F  AQ M++ +
Sbjct: 53  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 111

Query: 630 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 688
               +Q K +  +IL L+ AA+ HDLDH G NN+Y   +   LA  Y   S +E+HH   
Sbjct: 112 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 171

Query: 689 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 748
              IL  P   I S +  + +K   + +   ILATD+A + +    F E  +   F+  +
Sbjct: 172 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 229

Query: 749 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 808
                L   +L+  CD+S   +P  + +   + +  E+F Q DRE+ E  +     M+R+
Sbjct: 230 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 288

Query: 809 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 844
           K  K  + Q+GFI  + + ++E +T +    FP+++
Sbjct: 289 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 319


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,032,203
Number of Sequences: 37866
Number of extensions: 1397668
Number of successful extensions: 7440
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5432
Number of HSP's gapped (non-prelim): 1053
length of query: 875
length of database: 18,247,518
effective HSP length: 111
effective length of query: 764
effective length of database: 14,044,392
effective search space: 10729915488
effective search space used: 10729915488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.