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Search of human proteins with 61744430
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
(833 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 1676 0.0
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 1661 0.0
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 1655 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 595 e-170
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 518 e-146
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 455 e-128
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 410 e-114
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 406 e-113
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 406 e-113
gi|170650674 phosphodiesterase 6A [Homo sapiens] 393 e-109
gi|157364939 phosphodiesterase 6C [Homo sapiens] 377 e-104
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 342 1e-93
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 342 1e-93
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 312 9e-85
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 288 1e-77
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 288 1e-77
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 288 1e-77
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 138 2e-32
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 138 2e-32
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 138 2e-32
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 137 4e-32
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 137 4e-32
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 137 4e-32
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 137 4e-32
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 137 4e-32
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 137 4e-32
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 137 4e-32
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 137 4e-32
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 137 4e-32
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 137 4e-32
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 1676 bits (4340), Expect = 0.0
Identities = 833/833 (100%), Positives = 833/833 (100%)
Query: 1 MLPFGDKTREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKIS 60
MLPFGDKTREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKIS
Sbjct: 1 MLPFGDKTREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKIS 60
Query: 61 ASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSH 120
ASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSH
Sbjct: 61 ASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSH 120
Query: 121 LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIR 180
LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIR
Sbjct: 121 LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIR 180
Query: 181 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 240
LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA
Sbjct: 181 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 240
Query: 241 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 300
QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE
Sbjct: 241 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 300
Query: 301 EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREH 360
EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREH
Sbjct: 301 EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREH 360
Query: 361 DANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKN 420
DANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKN
Sbjct: 361 DANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKN 420
Query: 421 KVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT 480
KVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT
Sbjct: 421 KVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT 480
Query: 481 LEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL 540
LEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL
Sbjct: 481 LEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL 540
Query: 541 NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE 600
NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE
Sbjct: 541 NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE 600
Query: 601 ILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILS 660
ILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILS
Sbjct: 601 ILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILS 660
Query: 661 GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTA 720
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTA
Sbjct: 661 GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTA 720
Query: 721 CDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFID 780
CDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFID
Sbjct: 721 CDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFID 780
Query: 781 AICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 833
AICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
Sbjct: 781 AICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 833
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 1661 bits (4301), Expect = 0.0
Identities = 826/826 (100%), Positives = 826/826 (100%)
Query: 8 TREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRP 67
TREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRP
Sbjct: 50 TREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRP 109
Query: 68 LRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALC 127
LRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALC
Sbjct: 110 LRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALC 169
Query: 128 HKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGI 187
HKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGI
Sbjct: 170 HKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGI 229
Query: 188 VGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKS 247
VGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKS
Sbjct: 230 VGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKS 289
Query: 248 GNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEV 307
GNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEV
Sbjct: 290 GNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEV 349
Query: 308 ILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINY 367
ILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINY
Sbjct: 350 ILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINY 409
Query: 368 MYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQ 427
MYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQ
Sbjct: 410 MYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQ 469
Query: 428 LVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYH 487
LVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYH
Sbjct: 470 LVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYH 529
Query: 488 ASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQ 547
ASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQ
Sbjct: 530 ASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQ 589
Query: 548 MKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIA 607
MKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIA
Sbjct: 590 MKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIA 649
Query: 608 ALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEY 667
ALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEY
Sbjct: 650 ALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEY 709
Query: 668 KTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAIT 727
KTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAIT
Sbjct: 710 KTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAIT 769
Query: 728 KPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLY 787
KPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLY
Sbjct: 770 KPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLY 829
Query: 788 EALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 833
EALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
Sbjct: 830 EALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 875
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 1655 bits (4286), Expect = 0.0
Identities = 823/823 (100%), Positives = 823/823 (100%)
Query: 11 MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRP 70
MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRP
Sbjct: 1 MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRP 60
Query: 71 IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKI 130
IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKI
Sbjct: 61 IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKI 120
Query: 131 FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH 190
FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH
Sbjct: 121 FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH 180
Query: 191 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 250
VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG
Sbjct: 181 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 240
Query: 251 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILK 310
GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILK
Sbjct: 241 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILK 300
Query: 311 KIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYA 370
KIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYA
Sbjct: 301 KIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYA 360
Query: 371 QYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVN 430
QYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVN
Sbjct: 361 QYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVN 420
Query: 431 KMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASA 490
KMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASA
Sbjct: 421 KMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASA 480
Query: 491 AEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKH 550
AEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKH
Sbjct: 481 AEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKH 540
Query: 551 EVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALS 610
EVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALS
Sbjct: 541 EVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALS 600
Query: 611 HDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTT 670
HDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTT
Sbjct: 601 HDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTT 660
Query: 671 LKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPW 730
LKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPW
Sbjct: 661 LKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPW 720
Query: 731 PIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 790
PIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL
Sbjct: 721 PIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 780
Query: 791 THVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 833
THVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
Sbjct: 781 THVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN 823
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 595 bits (1535), Expect = e-170
Identities = 317/721 (43%), Positives = 468/721 (64%), Gaps = 27/721 (3%)
Query: 111 LELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGST 170
LELVKDIS+ LD+T+L +KI + + ++ ADR SLFLV ++ K L+S+ FDV G+
Sbjct: 206 LELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTP 265
Query: 171 LEEVSN----NCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 226
L S+ N +++ W KGI+G+V GE +NI DAY+D RFN E+D++TGYKT+S+LC
Sbjct: 266 LLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLC 325
Query: 227 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 286
MPI++ E++GVAQAINK G FTE DEK YL FCGI + NAQL+ S E +
Sbjct: 326 MPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384
Query: 287 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM 344
R++ LL++ + +FEEQ LE I+KKI + ++ ++C++ ++++ S F+ F +
Sbjct: 385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFEL 444
Query: 345 ECEELEKSSDTLTREHDANK------INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENT 398
+ ++ +E IN A+ V +T P+NI D +D RF +
Sbjct: 445 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 504
Query: 399 GNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCG 458
+ IRS+LC PI N +++IGV Q++N+++ KPF+ D++ EAFVIFCG
Sbjct: 505 SGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCG 555
Query: 459 LGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFS 518
LGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E + + AA +P L I D
Sbjct: 556 LGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIH 612
Query: 519 FSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN 578
F DF L +RMF +L +VQ F++ +E LCRW+L+V+KNYR V YHNWRHAFN
Sbjct: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFN 671
Query: 579 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI 638
Q MFA L Q+ LT++EILA+++ L HDLDHRG NN++ +S LAQLY S
Sbjct: 672 VCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSA 731
Query: 639 -MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI 697
+EHHHF+ +MIL S G+ I + LS +EY ++++KQ+ILATDL LY +RR EFFEL+
Sbjct: 732 TLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELV 791
Query: 698 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI 757
K +++ + +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL +
Sbjct: 792 SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKL 851
Query: 758 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+ P+LD NR KW+ L ++
Sbjct: 852 TPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
Query: 818 Q 818
+
Sbjct: 912 R 912
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 518 bits (1333), Expect = e-146
Identities = 272/623 (43%), Positives = 403/623 (64%), Gaps = 23/623 (3%)
Query: 205 EDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAY 264
+D RFN E+D++TGYKT+S+LCMPI++ E++GVAQAINK G FTE DEK Y
Sbjct: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMY 112
Query: 265 LAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQK 324
L FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ ++
Sbjct: 113 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 172
Query: 325 CTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKNT 376
C++ ++++ S F+ F + + ++ +E IN A+ V +T
Sbjct: 173 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 232
Query: 377 MEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENT 436
P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 233 GLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-- 286
Query: 437 GKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR 496
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 287 ---KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 343
Query: 497 ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRW 556
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCRW
Sbjct: 344 KFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 400
Query: 557 ILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR 616
+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDHR
Sbjct: 401 LLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHR 459
Query: 617 GVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIK 675
G NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++K
Sbjct: 460 GTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLK 519
Query: 676 QAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQR 735
Q+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I ++
Sbjct: 520 QSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQ 579
Query: 736 IAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSE 795
+AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 580 VAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNV 639
Query: 796 DCFPLLDGCRKNRQKWQALAEQQ 818
P+LD NR KW+ L +++
Sbjct: 640 KLKPMLDSVATNRSKWEELHQKR 662
Score = 107 bits (268), Expect = 3e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 103 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 161
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 190
Query: 162 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 211
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 191 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 249
Query: 212 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 271
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 250 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 307
Query: 272 LHNAQLYETSLLENKRNQVLLDLAS 296
++N +Y+ + V LD+ S
Sbjct: 308 INNTIMYDQVKKSWAKQSVALDVLS 332
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 455 bits (1170), Expect = e-128
Identities = 239/564 (42%), Positives = 360/564 (63%), Gaps = 22/564 (3%)
Query: 264 YLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQ 323
YL FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ +
Sbjct: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
Query: 324 KCTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKN 375
+C++ ++++ S F+ F + + ++ +E IN A+ V +
Sbjct: 64 RCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAS 123
Query: 376 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 435
T P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 124 TGLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG- 178
Query: 436 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 495
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 179 ----KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEV 234
Query: 496 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 555
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCR
Sbjct: 235 DKFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCR 291
Query: 556 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDH 615
W+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDH
Sbjct: 292 WLLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDH 350
Query: 616 RGVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKII 674
RG NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++
Sbjct: 351 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 410
Query: 675 KQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQ 734
KQ+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I +
Sbjct: 411 KQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISR 470
Query: 735 RIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVS 794
++AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 471 QVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVN 530
Query: 795 EDCFPLLDGCRKNRQKWQALAEQQ 818
P+LD NR KW+ L +++
Sbjct: 531 VKLKPMLDSVATNRSKWEELHQKR 554
Score = 107 bits (268), Expect = 3e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 103 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 161
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 82
Query: 162 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 211
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 83 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 141
Query: 212 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 271
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 142 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 199
Query: 272 LHNAQLYETSLLENKRNQVLLDLAS 296
++N +Y+ + V LD+ S
Sbjct: 200 INNTIMYDQVKKSWAKQSVALDVLS 224
Score = 34.3 bits (77), Expect = 0.49
Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Query: 450 LEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSA 509
++ ++ FCG+ I N Q++ A + + LEV++ EE+T +L+ + ++ A
Sbjct: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN---DLFEEQT-DLEKIVKKIMHRA 56
Query: 510 QTL 512
QTL
Sbjct: 57 QTL 59
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 410 bits (1054), Expect = e-114
Identities = 214/473 (45%), Positives = 310/473 (65%), Gaps = 20/473 (4%)
Query: 347 EELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCI 406
E +EKSS + IN A+ V +T P+NI D +D RF + + I
Sbjct: 15 ESMEKSS------YSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFH---I 65
Query: 407 RSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQM 466
RS+LC PI N +++IGV Q++N+++ KPF+ D++ EAFVIFCGLGI NT M
Sbjct: 66 RSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCGLGINNTIM 119
Query: 467 YEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSD 526
Y+ V+++ AKQ V L+VLSYHA+ ++ E + + AA +P L I D F DF L
Sbjct: 120 YDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIHFDDFSLDV 176
Query: 527 LETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAA 586
+RMF +L +VQ F++ +E LCRW+L+V+KNYR V YHNWRHAFN Q MFA
Sbjct: 177 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFNVCQLMFAM 235
Query: 587 LKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI-MEHHHFD 645
L Q+ LT++EILA+++ L HDLDHRG NN++ +S LAQLY S +EHHHF+
Sbjct: 236 LTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFN 295
Query: 646 QCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLE 705
+MIL S G+ I + LS +EY ++++KQ+ILATDL LY +RR EFFEL+ K +++
Sbjct: 296 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 355
Query: 706 DPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNR 765
+ +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL + P+ + +R
Sbjct: 356 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 415
Query: 766 EKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ 818
+K+++P +Q+ +ID+IC+ LY+AL V+ P+LD NR KW+ L +++
Sbjct: 416 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKR 468
Score = 97.4 bits (241), Expect = 5e-20
Identities = 51/133 (38%), Positives = 80/133 (60%), Gaps = 5/133 (3%)
Query: 166 AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQS 223
AE S E + + +W N I VA+ G P+NI DAY+DPRF+AE DQI+G+ +S
Sbjct: 9 AENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 67
Query: 224 ILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLL 283
+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+ ++N +Y+
Sbjct: 68 VLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLGINNTIMYDQVKK 125
Query: 284 ENKRNQVLLDLAS 296
+ V LD+ S
Sbjct: 126 SWAKQSVALDVLS 138
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 406 bits (1044), Expect = e-113
Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)
Query: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
++ + LLELV+D+ +++ + K+ + L+ ADR SLF+ + + + L +RLF
Sbjct: 54 EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
Query: 165 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 221
V S LE+ ++ I + G+VGHVA + +N++D E P F++ D++T YKT
Sbjct: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
Query: 222 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 281
+++L PI N ++ VV V A+NK NG FT +DE F YL F + L ++Y S
Sbjct: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
Query: 282 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 338
L N +R QVLL A+ +FEE +E K T+ +++ ++ ++ ++D F
Sbjct: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
Query: 339 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 371
V+ + E + S T + H +I +
Sbjct: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
Query: 372 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 431
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
Query: 432 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 491
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
Query: 492 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 532
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
Query: 533 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 592
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
Query: 593 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 652
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
Query: 653 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 708
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
Query: 709 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 761
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
Query: 762 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
Score = 34.7 bits (78), Expect = 0.38
Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)
Query: 282 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 339
L + + + LL+L + +E ++E ++ K+ + + +Q +C++F+ + ++ +
Sbjct: 50 LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
Query: 340 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 399
+F ++ + + + ++ +V T + +N+ DV++ F +
Sbjct: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
Query: 400 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 432
+ +++L TPI NGK V+ V VNK+
Sbjct: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 406 bits (1044), Expect = e-113
Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)
Query: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
++ + LLELV+D+ +++ + K+ + L+ ADR SLF+ + + + L +RLF
Sbjct: 54 EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
Query: 165 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 221
V S LE+ ++ I + G+VGHVA + +N++D E P F++ D++T YKT
Sbjct: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
Query: 222 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 281
+++L PI N ++ VV V A+NK NG FT +DE F YL F + L ++Y S
Sbjct: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
Query: 282 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 338
L N +R QVLL A+ +FEE +E K T+ +++ ++ ++ ++D F
Sbjct: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
Query: 339 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 371
V+ + E + S T + H +I +
Sbjct: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
Query: 372 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 431
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
Query: 432 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 491
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
Query: 492 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 532
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
Query: 533 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 592
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
Query: 593 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 652
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
Query: 653 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 708
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
Query: 709 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 761
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
Query: 762 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
Score = 34.7 bits (78), Expect = 0.38
Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)
Query: 282 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 339
L + + + LL+L + +E ++E ++ K+ + + +Q +C++F+ + ++ +
Sbjct: 50 LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
Query: 340 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 399
+F ++ + + + ++ +V T + +N+ DV++ F +
Sbjct: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
Query: 400 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 432
+ +++L TPI NGK V+ V VNK+
Sbjct: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 393 bits (1010), Expect = e-109
Identities = 251/785 (31%), Positives = 406/785 (51%), Gaps = 74/785 (9%)
Query: 110 LLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGS 169
+ +L++D +L + + L+ ADR SLF+ + L +RLF+V + +
Sbjct: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMY-RTRNGIAELATRLFNVHKDA 119
Query: 170 TLEE---VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 226
LE+ + + I + GIVGHVA + N+ + ED F VD +T YKT++IL
Sbjct: 120 VLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILA 179
Query: 227 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 286
PI N ++ VV + A+NK G+ FT++DE+ YL F +++ L E +
Sbjct: 180 SPIMNGKD-VVAIIMAVNKVDGSH--FTKRDEEILLKYLNFANLIMKVYHLSYLHNCETR 236
Query: 287 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMEC 346
R Q+LL S +FEE +E K T+ +F+ + ++ ++D F V+ +
Sbjct: 237 RGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLM 296
Query: 347 EELEKSSDTLTREHDANKIN-YMYAQYVKNTMEPLN-IPDVSKD-----KRFPWTTENTG 399
E+ S R D +IN Y Y+ + E + IP+ D P G
Sbjct: 297 GEVPPYSGP--RTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNG 354
Query: 400 NV---------------------NQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 438
+ + I+++L PI N KK +++GV N+ +
Sbjct: 355 LICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVN-KKEEIVGVATFYNRKDG---- 409
Query: 439 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-- 496
KPF+ DE +E+ F G + N YE++ + ++ + +++ YH EE +
Sbjct: 410 -KPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKI 468
Query: 497 -----------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTD 539
EL + A +P A +I F FSD L++LE C I+M+ +
Sbjct: 469 LKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYE 528
Query: 540 LNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDL 599
L +V F + E L R++ S+ K YRK + YHNWRH FN Q MF+ L GK++ TDL
Sbjct: 529 LKVVDKFHIPQEALVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587
Query: 600 EILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQIL 659
E LA++ AA HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L I
Sbjct: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIF 647
Query: 660 SGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN----------QFNLEDPHQ 709
L+ +++ + ++ AI+ATDLALY K+R F +++ ++ Q+ + + +
Sbjct: 648 QNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTR 707
Query: 710 KELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKN 769
KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L P +M+R K +
Sbjct: 708 KEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKAD 767
Query: 770 KIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE-KMLINGESG 828
++P +QVGFID +C +Y+ + E+ P+LDG NR++W+ALA++ + KM + E
Sbjct: 768 ELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
Query: 829 QAKRN 833
Q +++
Sbjct: 828 QKQQS 832
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 377 bits (968), Expect = e-104
Identities = 255/825 (30%), Positives = 419/825 (50%), Gaps = 97/825 (11%)
Query: 64 FDRPLRPIVVKDSEGTVSFLSDSEKKEQMPL-TPPRFDH----DEGDQCSRLLELVKDIS 118
FDR LR V L + K Q+P+ + F +E C LL V++
Sbjct: 24 FDRKLR----------VEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEG 73
Query: 119 SHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEV---S 175
+ H+ + L+ ADR S+FL C + + SRL DV S E+
Sbjct: 74 GTPEQGV--HRALQRLAHLLQADRCSMFL-CRSRNGIPEVASRLLDVTPTSKFEDNLVGP 130
Query: 176 NNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREE 235
+ + + GIVG A + N+ D ++ F+ +D+ TGY T+++L PI +E
Sbjct: 131 DKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKE- 189
Query: 236 VVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVL---HNAQLYETSLLENKRNQVLL 292
V+ V A+NK N F+++DE+ F+ YL F I+L H + +Y +E++R+Q+L+
Sbjct: 190 VLAVIMAVNKV--NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYN---IESRRSQILM 244
Query: 293 DLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKS 352
A+ +FEE +E K T+ S++ ++ +I ++D F + ++ E+E
Sbjct: 245 WSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPY 304
Query: 353 SDTLTREHDANKIN-YMYAQYVKNTMEPLNI---------------PDVSKDKRF----- 391
T D ++N Y Y+ + E + + P + F
Sbjct: 305 KGPKTP--DGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMM 362
Query: 392 -----PWTTENTGNVNQQ--CIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNR 444
+ T G V++ I+++L PI N KK ++GV N+ + KPF+
Sbjct: 363 NAPADEYFTFQKGPVDETGWVIKNVLSLPIVN-KKEDIVGVATFYNRKDG-----KPFDE 416
Query: 445 NDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-------- 496
+DE E F G + NT Y+ + + ++ + E+L A EE +
Sbjct: 417 HDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEK 476
Query: 497 ------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ 544
+L ++ +P ++ ++ +F FSDF L++ C IR+F ++N+V+
Sbjct: 477 LNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVE 536
Query: 545 NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILAL 604
F++ EVL RW+ +V+K YR V YHNWRH FN Q MF L G+++ TDLE A+
Sbjct: 537 KFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAM 595
Query: 605 LIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSI 664
L AA HD+DHRG NN Y +S PLA+L+ SI+E HH + +L I L+
Sbjct: 596 LAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNK 655
Query: 665 EEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK-NQFNLE---------DPHQKELFL 714
+++T + + + AI+ATDLALY K+R F +++ Q E DP +KE+ +
Sbjct: 656 RQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIM 715
Query: 715 AMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSM 774
AM+MTACDLSAITKPW +Q ++A +VA EF++QGD ER L +P +M+R K++++P +
Sbjct: 716 AMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKL 775
Query: 775 QVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
QVGFID +C +Y+ + ++ P+L G + NR +W++LA++ +
Sbjct: 776 QVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYD 820
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 187 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 246
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 208
Query: 247 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 306
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 307 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 366
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 327
Query: 367 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 425
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 328 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 381
Query: 426 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 485
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 382 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436
Query: 486 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 545
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 437 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 490
Query: 546 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 605
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 491 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 547
Query: 606 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 665
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 548 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 607
Query: 666 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 725
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 608 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 667
Query: 726 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 785
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 668 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 726
Query: 786 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
Y LT + PLL CR N +W+ + +E
Sbjct: 727 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 760
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 123 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 180
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 267 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 323
Query: 181 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 240
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 324 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 382
Query: 241 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 278
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 383 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 418
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 187 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 246
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 161 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 218
Query: 247 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 306
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 219 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 278
Query: 307 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 366
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 279 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 337
Query: 367 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 425
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 391
Query: 426 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 485
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 392 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446
Query: 486 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 545
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 447 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 500
Query: 546 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 605
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 501 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 557
Query: 606 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 665
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 558 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 617
Query: 666 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 725
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 618 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 677
Query: 726 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 785
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 678 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 736
Query: 786 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
Y LT + PLL CR N +W+ + +E
Sbjct: 737 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 770
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 123 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 180
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 277 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 333
Query: 181 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 240
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 334 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 392
Query: 241 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 278
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 393 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 428
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 312 bits (799), Expect = 9e-85
Identities = 169/478 (35%), Positives = 274/478 (57%), Gaps = 39/478 (8%)
Query: 372 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 431
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 68 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 125
Query: 432 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 491
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 126 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
Query: 492 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 532
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
Query: 533 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 592
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 299
Query: 593 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 652
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359
Query: 653 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 708
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 418
Query: 709 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 761
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 419 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 478
Query: 762 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 479 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 536
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 5/106 (4%)
Query: 186 GIVGHVAALGEPLNIKDAYEDPRFNAEVDQI--TGYKTQSILCMPIKNHREEVVGVAQAI 243
G+ +VA G NI +A D F + + +G+ +++L MPI N +EE+VGVA
Sbjct: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
Query: 244 NKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYE-TSLLENKRN 288
N+K G F E+DE + F G + N Y+ + LEN+++
Sbjct: 124 NRKDGK--PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKD 167
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 288 bits (737), Expect = 1e-77
Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)
Query: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
D+ ++L+L ++ LD ++L K+ ++ A R L LV ED N + + D
Sbjct: 216 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 272
Query: 165 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 223
G EEVS G +G V + + +KD ED + ++ + G + Q+
Sbjct: 273 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 320
Query: 224 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 282
+LC+P I ++VV +A A NK G+ FT++DE + VL + ++
Sbjct: 321 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 378
Query: 283 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 342
Q LL +A +F + V+L++I + + C++F++D++ + + VF
Sbjct: 379 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 436
Query: 343 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 402
+ E + + A +V T + LNIPD F +++
Sbjct: 437 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 489
Query: 403 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 462
R++LC PIKN + +VIGV +LVNK+ F++ DE AF I+CG+ I
Sbjct: 490 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 540
Query: 463 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 521
++ +Y+ V A + + E++ YH +++E +L L + P +A F+++
Sbjct: 541 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 598
Query: 522 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 581
L + +T++ + M D+N + N+++ L R+ L VKK YR + YHNW HAF+ +
Sbjct: 599 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 657
Query: 582 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 639
+ K ++ N L D+EI AL I+ + HDLDHRG NNS+ S+ LA LY S+M
Sbjct: 658 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 717
Query: 640 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 699
E HHF Q + ILN+ G I S ++Y+ L +++ ILATDLA ++ R + + + +
Sbjct: 718 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 776
Query: 700 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 759
++ + L L +LMT+CDLS TK W ++IAEL+ EFF QGD E K + P
Sbjct: 777 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 835
Query: 760 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
++M+REK IP +Q+ F++ I + +Y+ L + L + NR+ W ++ +
Sbjct: 836 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 892
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 288 bits (737), Expect = 1e-77
Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)
Query: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
D+ ++L+L ++ LD ++L K+ ++ A R L LV ED N + + D
Sbjct: 218 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 274
Query: 165 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 223
G EEVS G +G V + + +KD ED + ++ + G + Q+
Sbjct: 275 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 322
Query: 224 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 282
+LC+P I ++VV +A A NK G+ FT++DE + VL + ++
Sbjct: 323 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 380
Query: 283 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 342
Q LL +A +F + V+L++I + + C++F++D++ + + VF
Sbjct: 381 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 438
Query: 343 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 402
+ E + + A +V T + LNIPD F +++
Sbjct: 439 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 491
Query: 403 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 462
R++LC PIKN + +VIGV +LVNK+ F++ DE AF I+CG+ I
Sbjct: 492 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 542
Query: 463 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 521
++ +Y+ V A + + E++ YH +++E +L L + P +A F+++
Sbjct: 543 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 600
Query: 522 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 581
L + +T++ + M D+N + N+++ L R+ L VKK YR + YHNW HAF+ +
Sbjct: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 659
Query: 582 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 639
+ K ++ N L D+EI AL I+ + HDLDHRG NNS+ S+ LA LY S+M
Sbjct: 660 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 719
Query: 640 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 699
E HHF Q + ILN+ G I S ++Y+ L +++ ILATDLA ++ R + + + +
Sbjct: 720 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 778
Query: 700 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 759
++ + L L +LMT+CDLS TK W ++IAEL+ EFF QGD E K + P
Sbjct: 779 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 837
Query: 760 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
++M+REK IP +Q+ F++ I + +Y+ L + L + NR+ W ++ +
Sbjct: 838 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 894
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 288 bits (737), Expect = 1e-77
Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)
Query: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
D+ ++L+L ++ LD ++L K+ ++ A R L LV ED N + + D
Sbjct: 225 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 281
Query: 165 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 223
G EEVS G +G V + + +KD ED + ++ + G + Q+
Sbjct: 282 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 329
Query: 224 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 282
+LC+P I ++VV +A A NK G+ FT++DE + VL + ++
Sbjct: 330 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 387
Query: 283 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 342
Q LL +A +F + V+L++I + + C++F++D++ + + VF
Sbjct: 388 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 445
Query: 343 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 402
+ E + + A +V T + LNIPD F +++
Sbjct: 446 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 498
Query: 403 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 462
R++LC PIKN + +VIGV +LVNK+ F++ DE AF I+CG+ I
Sbjct: 499 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 549
Query: 463 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 521
++ +Y+ V A + + E++ YH +++E +L L + P +A F+++
Sbjct: 550 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 607
Query: 522 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 581
L + +T++ + M D+N + N+++ L R+ L VKK YR + YHNW HAF+ +
Sbjct: 608 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 666
Query: 582 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 639
+ K ++ N L D+EI AL I+ + HDLDHRG NNS+ S+ LA LY S+M
Sbjct: 667 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 726
Query: 640 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 699
E HHF Q + ILN+ G I S ++Y+ L +++ ILATDLA ++ R + + + +
Sbjct: 727 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 785
Query: 700 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 759
++ + L L +LMT+CDLS TK W ++IAEL+ EFF QGD E K + P
Sbjct: 786 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 844
Query: 760 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
++M+REK IP +Q+ F++ I + +Y+ L + L + NR+ W ++ +
Sbjct: 845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 901
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 138 bits (348), Expect = 2e-32
Identities = 111/397 (27%), Positives = 188/397 (47%), Gaps = 39/397 (9%)
Query: 465 QMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQ---------SLAAAVVPS------- 508
Q+ E + R Q +E+ A A + + SL++A VP
Sbjct: 151 QVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQ 210
Query: 509 ----AQTLKITD-FSFSDFELSDLE-----TALCTIRMFTDLNLVQNFQMKHEVLCRWIL 558
A+ L+ T+ + F++++L TA+ +F + +L++ FQ+ + L ++L
Sbjct: 211 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAII-FSIFQERDLLKTFQIPADTLATYLL 269
Query: 559 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 618
++ +Y NVAYHN HA + AQ L ++ TDLEILA L A+ HD+DH GV
Sbjct: 270 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 329
Query: 619 NNSYIQRSEHPLAQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQA 677
+N ++ + LA +Y S++E+HH +L + I LS ++ + +++
Sbjct: 330 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 389
Query: 678 ILATDLALYIKRRGEFFELIRKNQFN------LEDPHQKELFLAMLMTACDLSAITKPWP 731
+LATD++ ++ + ++ + L++ + L L+ DLS TKP P
Sbjct: 390 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 449
Query: 732 IQQRIAELVATEFFDQGDRERKE-LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 790
+ ++ + + EFF QGDRER+ L+I P M + + QVGFID I L+E
Sbjct: 450 LYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWETW 506
Query: 791 TH-VSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGE 826
V D LLD NR+ +Q+ + L N E
Sbjct: 507 ADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 543
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 138 bits (348), Expect = 2e-32
Identities = 111/397 (27%), Positives = 188/397 (47%), Gaps = 39/397 (9%)
Query: 465 QMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQ---------SLAAAVVPS------- 508
Q+ E + R Q +E+ A A + + SL++A VP
Sbjct: 225 QVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQ 284
Query: 509 ----AQTLKITD-FSFSDFELSDLE-----TALCTIRMFTDLNLVQNFQMKHEVLCRWIL 558
A+ L+ T+ + F++++L TA+ +F + +L++ FQ+ + L ++L
Sbjct: 285 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAII-FSIFQERDLLKTFQIPADTLATYLL 343
Query: 559 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 618
++ +Y NVAYHN HA + AQ L ++ TDLEILA L A+ HD+DH GV
Sbjct: 344 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 403
Query: 619 NNSYIQRSEHPLAQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQA 677
+N ++ + LA +Y S++E+HH +L + I LS ++ + +++
Sbjct: 404 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 463
Query: 678 ILATDLALYIKRRGEFFELIRKNQFN------LEDPHQKELFLAMLMTACDLSAITKPWP 731
+LATD++ ++ + ++ + L++ + L L+ DLS TKP P
Sbjct: 464 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 523
Query: 732 IQQRIAELVATEFFDQGDRERKE-LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 790
+ ++ + + EFF QGDRER+ L+I P M + + QVGFID I L+E
Sbjct: 524 LYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWETW 580
Query: 791 TH-VSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGE 826
V D LLD NR+ +Q+ + L N E
Sbjct: 581 ADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 617
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 138 bits (348), Expect = 2e-32
Identities = 111/397 (27%), Positives = 188/397 (47%), Gaps = 39/397 (9%)
Query: 465 QMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQ---------SLAAAVVPS------- 508
Q+ E + R Q +E+ A A + + SL++A VP
Sbjct: 257 QVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQ 316
Query: 509 ----AQTLKITD-FSFSDFELSDLE-----TALCTIRMFTDLNLVQNFQMKHEVLCRWIL 558
A+ L+ T+ + F++++L TA+ +F + +L++ FQ+ + L ++L
Sbjct: 317 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAII-FSIFQERDLLKTFQIPADTLATYLL 375
Query: 559 SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV 618
++ +Y NVAYHN HA + AQ L ++ TDLEILA L A+ HD+DH GV
Sbjct: 376 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 435
Query: 619 NNSYIQRSEHPLAQLYCH-SIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQA 677
+N ++ + LA +Y S++E+HH +L + I LS ++ + +++
Sbjct: 436 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 495
Query: 678 ILATDLALYIKRRGEFFELIRKNQFN------LEDPHQKELFLAMLMTACDLSAITKPWP 731
+LATD++ ++ + ++ + L++ + L L+ DLS TKP P
Sbjct: 496 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 555
Query: 732 IQQRIAELVATEFFDQGDRERKE-LNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL 790
+ ++ + + EFF QGDRER+ L+I P M + + QVGFID I L+E
Sbjct: 556 LYRQWTDRIMAEFFQQGDRERESGLDISP---MCDKHTASVEKSQVGFIDYIAHPLWETW 612
Query: 791 TH-VSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGE 826
V D LLD NR+ +Q+ + L N E
Sbjct: 613 ADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 649
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 121
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 122 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 181
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 182 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 239
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 240 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 298
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 299 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 329
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 121
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 122 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 181
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 182 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 239
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 240 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 298
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 299 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 329
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 244 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 302
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 303 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 362
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 363 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 420
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 421 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 479
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 480 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 510
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 229 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 287
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 288 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 347
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 348 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 405
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 406 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 464
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 465 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 495
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 203 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 261
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 262 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 321
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 322 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 379
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 380 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 438
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 439 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 469
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 53 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 111
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 112 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 171
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 172 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 229
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 230 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 288
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 289 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 319
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 121
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 122 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 181
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 182 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 239
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 240 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 298
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 299 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 329
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 168 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 226
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 227 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 286
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 287 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 344
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 345 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 403
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 404 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 434
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 136 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 194
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 195 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 254
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 255 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 312
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 313 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 371
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 372 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 402
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 137 bits (345), Expect = 4e-32
Identities = 87/276 (31%), Positives = 141/276 (51%), Gaps = 10/276 (3%)
Query: 528 ETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAAL 587
E C M+ DL LV++F + L RW+ V NYR N +HN+RH F AQ M++ +
Sbjct: 53 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMV 111
Query: 588 KAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH-SIMEHHHFDQ 646
+Q K + +IL L+ AA+ HDLDH G NN+Y + LA Y S +E+HH
Sbjct: 112 WLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAV 171
Query: 647 CLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLED 706
IL P I S + + +K + + ILATD+A + + F E + F+ +
Sbjct: 172 AFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKE--KMENFDYSN 229
Query: 707 PHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNRE 766
L +L+ CD+S +P + + + + E+F Q DRE+ E + M+R+
Sbjct: 230 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLPVAPFMDRD 288
Query: 767 KKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLD 802
K K + Q+GFI + + ++E +T + FP+++
Sbjct: 289 KVTK-ATAQIGFIKFVLIPMFETVTKL----FPMVE 319
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,265,831
Number of Sequences: 37866
Number of extensions: 1314354
Number of successful extensions: 3821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3448
Number of HSP's gapped (non-prelim): 110
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.