Search of human proteins with 13435386

Search of human proteins with 13435386

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide
4 [Homo sapiens]
         (503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...  1012   0.0  
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   902   0.0  
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   867   0.0  
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   792   0.0  
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   787   0.0  
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   662   0.0  
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   320   2e-87
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   320   2e-87
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [...   250   2e-66
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   168   9e-42
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        166   4e-41
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   159   6e-39
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   158   1e-38
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   154   1e-37
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   153   3e-37
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   152   5e-37
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   152   5e-37
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   150   3e-36
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   149   8e-36
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   148   1e-35
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   148   1e-35
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   147   2e-35
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  146   5e-35
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   142   9e-34
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   140   4e-33
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   136   4e-32
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   131   2e-30
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   129   5e-30
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   128   1e-29
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   127   2e-29

>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score = 1012 bits (2616), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
           MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
Sbjct: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60

Query: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
           DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
Sbjct: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
           AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180

Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
           MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
Sbjct: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
           FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
           IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360

Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420
           NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
Sbjct: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480
           KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 481 GLLQPEKPVVLKVESRDGTVSGA 503
           GLLQPEKPVVLKVESRDGTVSGA
Sbjct: 481 GLLQPEKPVVLKVESRDGTVSGA 503


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  902 bits (2332), Expect = 0.0
 Identities = 445/503 (88%), Positives = 475/503 (94%)

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
           M LIP+LA+ETWLLLAVSL+LLYLYGT +HGLFKKLGIPGPTPLPFLGN LS+ KG+  F
Sbjct: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60

Query: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
           DMEC+KKY KVWG YD QQP+LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK+AISI
Sbjct: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
           AEDEEWKR+RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLK VFGAYS
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180

Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
           MDVITSTSFGV+IDSLNNPQDPFVENTKKLLRF+ LDPF LSI VFPFL PILE LNI V
Sbjct: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
           FPR+V +FL KSVK++KE RL++TQKHRVDFLQLMIDSQNSK++E+HKALSDLEL+AQSI
Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300

Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
           IFIFAGYETTSSVLSFI+YELATHPDVQQK+Q+EID VLPNKAPPTYDTVLQ+EYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360

Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420
           NETLRLFP+AMRLERVCKKDVEINGMFIPKGVVVMIPSY LH DPKYWTEPEKFLPERFS
Sbjct: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480
           KKNKDNIDPYIYTPFGSGPRNCIGMRFAL+NMKLAL+RVLQNFSFKPCKETQIPLKL  G
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480

Query: 481 GLLQPEKPVVLKVESRDGTVSGA 503
           GLL  EKP+VLK ESRD TVSGA
Sbjct: 481 GLLLTEKPIVLKAESRDETVSGA 503


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  867 bits (2241), Expect = 0.0
 Identities = 423/502 (84%), Positives = 462/502 (92%), Gaps = 1/502 (0%)

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
           M LIP+LA+ETWLLLAVSLVLLYLYGT +HGLFK+LGIPGPTPLP LGN+LSY +G   F
Sbjct: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60

Query: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
           D EC+KKYGK+WG Y+GQ PVLAITDPD+I+TVLVKECYSVFTNRR  GPVGFMKSAIS+
Sbjct: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
           AEDEEWKR+RSLLSPTFTSGKLKEM PIIAQYGDVLVRNLRREAE GKPVTLKD+FGAYS
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180

Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
           MDVIT TSFGVNIDSLNNPQDPFVE+TKK L+F FLDP FLSI +FPFL P+ E LN+ +
Sbjct: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
           FP++  NFL KSV RMK+SRL D QKHR+DFLQLMIDSQNSKETESHKALSDLEL AQSI
Sbjct: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300

Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
           IFIFAGYETTSSVLSF +YELATHPDVQQKLQ+EIDAVLPNKAPPTYD V+QMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360

Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420
           NETLRLFP+A+RLER CKKDVEING+FIPKG +V+IP+YALH DPKYWTEPE+F PERFS
Sbjct: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480
           KK KD+IDPYIYTPFG+GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL   
Sbjct: 421 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 479

Query: 481 GLLQPEKPVVLKVESRDGTVSG 502
           GLLQPEKP+VLKV+SRDGT+SG
Sbjct: 480 GLLQPEKPIVLKVDSRDGTLSG 501


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  792 bits (2045), Expect = 0.0
 Identities = 381/502 (75%), Positives = 436/502 (86%)

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
           M LIP+ AMETW+L+A SLVLLY+YGTHSH LFKKLGIPGPTPLPFLG IL Y +G   F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
           D EC++KYG++WG Y+GQQP+L I DPDMIKTVLVKECYSVFTN+ P GP+GF+KSA+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
           AEDEEWKR+R+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
           MDVIT T FGVN+DSLNNPQDPF++N KKLL+ DFLDPF L I++FPFL P+ E LNI +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
           FP++VT+FL+ S++RMKESRL+D QKHRVDF Q MIDSQNSKET+SHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
           I IFA Y+TTS+ L FIMYELATHPDVQQKLQEEIDAVLPNKAP TYD ++QMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420
           NETLRLFP+  R+ RVCKKD+EING+FIPKG+ VM+P YALH DPKYWTEPEKF PERFS
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420

Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480
           KKNKD+ID Y Y PFG+GPRNCIGMRFAL N+KLA+IR LQNFSFKPCKETQIPLKL   
Sbjct: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480

Query: 481 GLLQPEKPVVLKVESRDGTVSG 502
            +LQPEKP+VLKV  RDG  SG
Sbjct: 481 PILQPEKPIVLKVHLRDGITSG 502


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  787 bits (2033), Expect = 0.0
 Identities = 381/503 (75%), Positives = 436/503 (86%), Gaps = 1/503 (0%)

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
           M LIP+ AMETW+L+A SLVLLY+YGTHSH LFKKLGIPGPTPLPFLG IL Y +G   F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
           D EC++KYG++WG Y+GQQP+L I DPDMIKTVLVKECYSVFTN+ P GP+GF+KSA+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
           AEDEEWKR+R+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
           MDVIT T FGVN+DSLNNPQDPF++N KKLL+ DFLDPF L I++FPFL P+ E LNI +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
           FP++VT+FL+ S++RMKESRL+D QKHRVDF Q MIDSQNSKET+SHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
           I IFA Y+TTS+ L FIMYELATHPDVQQKLQEEIDAVLPNKAP TYD ++QMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE-RF 419
           NETLRLFP+  R+ RVCKKD+EING+FIPKG+ VM+P YALH DPKYWTEPEKF PE RF
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420

Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSL 479
           SKKNKD+ID Y Y PFG+GPRNCIGMRFAL N+KLA+IR LQNFSFKPCKETQIPLKL  
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Query: 480 GGLLQPEKPVVLKVESRDGTVSG 502
             +LQPEKP+VLKV  RDG  SG
Sbjct: 481 LPILQPEKPIVLKVHLRDGITSG 503


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  662 bits (1708), Expect = 0.0
 Identities = 316/418 (75%), Positives = 365/418 (87%)

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
           M LIP+ AMETW+L+A SLVLLY+YGTHSH LFKKLGIPGPTPLPFLG IL Y +G   F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
           D EC++KYG++WG Y+GQQP+L I DPDMIKTVLVKECYSVFTN+ P GP+GF+KSA+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
           AEDEEWKR+R+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
           MDVIT T FGVN+DSLNNPQDPF++N KKLL+ DFLDPF L I++FPFL P+ E LNI +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
           FP++VT+FL+ S++RMKESRL+D QKHRVDF Q MIDSQNSKET+SHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
           I IFA Y+TTS+ L FIMYELATHPDVQQKLQEEIDAVLPNKAP TYD ++QMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
           NETLRLFP+  R+ RVCKKD+EING+FIPKG+ VM+P YALH DPKYWTEPEKF PER
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  320 bits (820), Expect = 2e-87
 Identities = 189/526 (35%), Positives = 289/526 (54%), Gaps = 45/526 (8%)

Query: 9   METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKY 68
           M T  L    L LL  Y T +    +KLG+  P P PF+GN+  + +GF    ME  K Y
Sbjct: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY 75

Query: 69  GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA--EDEEW 126
           G + G+Y G++  + I++PDMIK VLV E +S FTNR   G + F   A S+    D+ W
Sbjct: 76  GPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASG-LEFKSVADSVLFLRDKRW 133

Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
           + +R  L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S
Sbjct: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVAS 193

Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP-FLIPILEVLNICVFPR-- 243
            +FG  +DS   P+DPFV++ K+   F    P  + +  FP  ++P+  +L     P   
Sbjct: 194 VAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARIL-----PNKN 248

Query: 244 --EVTNFLRKSVKRMKESRLEDT-QKHRVDFLQLMIDSQNSKE----------------- 283
             E+  F  K ++ +   R +   ++ R DFLQ+++D+++S                   
Sbjct: 249 RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST 308

Query: 284 ------TESH------KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331
                 +  H      + L+  E+V Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL
Sbjct: 309 GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL 368

Query: 332 QEEIDAVLPNKAPPTYDTVLQ-MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390
             E+D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP 
Sbjct: 369 LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPA 428

Query: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450
           G V+ +   ALH DP++W  PE F PERF+ + +    P+ Y PFG+GPR+C+G+R  L+
Sbjct: 429 GAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLL 488

Query: 451 NMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
            +KL L+ VL  F F+ C ETQ+PL+L     L P+  V +K+ SR
Sbjct: 489 EVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  320 bits (820), Expect = 2e-87
 Identities = 189/526 (35%), Positives = 289/526 (54%), Gaps = 45/526 (8%)

Query: 9   METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKY 68
           M T  L    L LL  Y T +    +KLG+  P P PF+GN+  + +GF    ME  K Y
Sbjct: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY 75

Query: 69  GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA--EDEEW 126
           G + G+Y G++  + I++PDMIK VLV E +S FTNR   G + F   A S+    D+ W
Sbjct: 76  GPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASG-LEFKSVADSVLFLRDKRW 133

Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
           + +R  L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S
Sbjct: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVAS 193

Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP-FLIPILEVLNICVFPR-- 243
            +FG  +DS   P+DPFV++ K+   F    P  + +  FP  ++P+  +L     P   
Sbjct: 194 VAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARIL-----PNKN 248

Query: 244 --EVTNFLRKSVKRMKESRLEDT-QKHRVDFLQLMIDSQNSKE----------------- 283
             E+  F  K ++ +   R +   ++ R DFLQ+++D+++S                   
Sbjct: 249 RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST 308

Query: 284 ------TESH------KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331
                 +  H      + L+  E+V Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL
Sbjct: 309 GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL 368

Query: 332 QEEIDAVLPNKAPPTYDTVLQ-MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390
             E+D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP 
Sbjct: 369 LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPA 428

Query: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450
           G V+ +   ALH DP++W  PE F PERF+ + +    P+ Y PFG+GPR+C+G+R  L+
Sbjct: 429 GAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLL 488

Query: 451 NMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
            +KL L+ VL  F F+ C ETQ+PL+L     L P+  V +K+ SR
Sbjct: 489 EVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
           [Homo sapiens]
          Length = 460

 Score =  250 bits (638), Expect = 2e-66
 Identities = 155/449 (34%), Positives = 240/449 (53%), Gaps = 45/449 (10%)

Query: 9   METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKY 68
           M T  L    L LL  Y T +    +KLG+  P P PF+GN+  + +GF    ME  K Y
Sbjct: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY 75

Query: 69  GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA--EDEEW 126
           G + G+Y G++  + I++PDMIK VLV E +S FTNR   G + F   A S+    D+ W
Sbjct: 76  GPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASG-LEFKSVADSVLFLRDKRW 133

Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
           + +R  L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S
Sbjct: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVAS 193

Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP-FLIPILEVLNICVFPR-- 243
            +FG  +DS   P+DPFV++ K+   F    P  + +  FP  ++P+  +L     P   
Sbjct: 194 VAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARIL-----PNKN 248

Query: 244 --EVTNFLRKSVKRMKESR-LEDTQKHRVDFLQLMIDSQNS------------------- 281
             E+  F  K ++ +   R  +  ++ R DFLQ+++D+++S                   
Sbjct: 249 RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST 308

Query: 282 ----------KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331
                     + +   + L+  E+V Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL
Sbjct: 309 GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL 368

Query: 332 QEEIDAVLPNKAPPTYDTVLQ-MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390
             E+D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP 
Sbjct: 369 LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPA 428

Query: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERF 419
           G V+ +   ALH DP++W  PE F PER+
Sbjct: 429 GAVLEMAVGALHHDPEHWPSPETFNPERY 457


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  168 bits (426), Expect = 9e-42
 Identities = 121/458 (26%), Positives = 220/458 (48%), Gaps = 47/458 (10%)

Query: 65  HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK----ECYSVFTNRRPFGPVGFMKSAISI 120
           H    K+W    G  P++A+ + + ++ +L      +  S++    P+  +G + S    
Sbjct: 86  HMPLLKLWV---GPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTST--- 139

Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY- 179
               +W+  R +L+PTF    L++ + I+ +  ++LV+ L +          ++ F  + 
Sbjct: 140 --GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-------QEAFNCFF 190

Query: 180 -----SMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF---------LDPFFLSITV 225
                ++D+I  T+ G NI + +N    +V    ++    F         LD ++L    
Sbjct: 191 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKE 250

Query: 226 ---FPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSK 282
                  + IL      V              R        ++  R  FL L++    S 
Sbjct: 251 GWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL----SV 306

Query: 283 ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PN 341
             +    LS  ++  +   F+F G++TT++ +++ +Y L ++P+VQ+K+  E+D V   +
Sbjct: 307 TDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 366

Query: 342 KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401
             P T + + ++ YL+ V+ ETLRLFP      R   +D E+ G  + KG   +I  YAL
Sbjct: 367 DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYAL 426

Query: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461
           HRDP+Y+  PE+F PERF  +N     PY Y PF +GPRNCIG +FA+M  K  L  +L+
Sbjct: 427 HRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR 486

Query: 462 NFSFKPCKETQIPLKLSLGG--LLQPEKPVVLKVESRD 497
           +F  +  ++ +   +L L G  +L+P   + +K++ R+
Sbjct: 487 HFWIESNQKRE---ELGLEGQLILRPSNGIWIKLKRRN 521


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  166 bits (421), Expect = 4e-41
 Identities = 116/420 (27%), Positives = 208/420 (49%), Gaps = 29/420 (6%)

Query: 83  AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142
           ++ DPD  K +L ++      + +      ++   +   +  +WK+ R ++ P F    L
Sbjct: 92  SVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKKHRQIVKPGFNISIL 149

Query: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG----VNIDSLNN 198
           K  + ++++   +++            + L       ++D I   +F     + +DS  +
Sbjct: 150 KIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLD 209

Query: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKE 258
                V N  K+      +    +  VF F     +      F +E+  F  K ++  KE
Sbjct: 210 SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSS---QGQIFSKFNQELHQFTEKVIQDRKE 266

Query: 259 S-----RLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313
           S     + + TQK R DFL +++    S ++E+ K  S+ +L A+   F+FAG++TTSS 
Sbjct: 267 SLKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSA 322

Query: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373
           +S+I+Y LA +P+ QQ+ ++EI  +L + +  T++ + QM Y  M + E LRL+   + +
Sbjct: 323 ISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNI 382

Query: 374 ERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432
            R+  K +   +G  +P G+ V I  +ALH +P +W +P+ F P RFS++N + I PY +
Sbjct: 383 SRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAF 442

Query: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLK 492
            PF +G RNCIG  FA++  K+A+   L  F   P   ++ P         QP + VVLK
Sbjct: 443 IPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP-DHSRPP---------QPVRQVVLK 492


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  159 bits (402), Expect = 6e-39
 Identities = 122/472 (25%), Positives = 232/472 (49%), Gaps = 30/472 (6%)

Query: 39  PGPTPLPFLGNILSYHKGFCMFDM-----ECHKKYGKVWGFYDGQ-QPVLAITDPDMIKT 92
           P P    FLG     H+ F   D      E  +KY + + F+ G  Q    I DPD  KT
Sbjct: 47  PAPPTHWFLG-----HQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKT 101

Query: 93  VLVK-ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
           +L + +  S +  +  F P   +   ++  +  +W + R LL+P F    LK  + ++A 
Sbjct: 102 LLSRTDPKSQYLQK--FSPP-LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAH 158

Query: 152 YGDVLVRNLRREAET-GKPVTLKDVFGAYSMDVITSTSFGVNID-SLNNPQDPFVENTKK 209
              +++    +   T    V + +   + S+D+I   +F    +   N+  DP+ +   +
Sbjct: 159 SVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFE 218

Query: 210 LLRFDFLDPFFL---SITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES--RLEDT 264
           L +  F   + L   S  +F           +     + T+ + +  K+  ++  + ++T
Sbjct: 219 LSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNT 278

Query: 265 QKHRV-DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323
            K +  DFL +++ +++    ES  + SD+++ ++   F+ AG++T ++ +S+I+Y LA 
Sbjct: 279 PKRKYQDFLDIVLSAKD----ESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLAL 334

Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
           +P+ Q++ +EE+  +L + +  T+D + +M Y  M + ET RL P    + R   K +  
Sbjct: 335 NPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTF 394

Query: 384 -NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
            +G  +P G+ V++  + LH +P  W  P+ F P RFS++N D   PY Y PF +G RNC
Sbjct: 395 PDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNC 454

Query: 443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVE 494
           IG  FA++ +K+ +  +L +F   P  +   PL      +L+P+  + L ++
Sbjct: 455 IGQEFAMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYLHLK 504


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  158 bits (400), Expect = 1e-38
 Identities = 119/440 (27%), Positives = 217/440 (49%), Gaps = 44/440 (10%)

Query: 80  PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----SAISIAEDEEWKRLRSLLSP 135
           P + +  PD I+++      ++      F  + F+K      I ++  ++W R R +L+P
Sbjct: 97  PFIVLCHPDTIRSI-TNASAAIAPKDNLF--IRFLKPWLGEGILLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKDVFGAYSMDVITSTSFGVNID 194
            F    LK  + I  +  ++++   +  A  G   + + +     ++D +    F  +  
Sbjct: 154 AFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSH 213

Query: 195 SLNNPQD---------PFVENTKK--LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPR 243
               P +           VE   +  L   DFL  ++LS     F          C    
Sbjct: 214 CQERPSEYIATILELSALVEKRSQHILQHMDFL--YYLSHDGRRFH-------RACRLVH 264

Query: 244 EVTN-FLRKSVKRMKESRLEDTQKHR-----VDFLQLMIDSQNSKETESHKALSDLELVA 297
           + T+  +R+  + +    ++D  K +     +DF+ +++ S++    E  KALSD ++ A
Sbjct: 265 DFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRA 320

Query: 298 QSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEY 355
           ++  F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + Q+ +
Sbjct: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPF 380

Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414
           L M V E+LRL P A  + R C +D+ + +G  IPKG+  +I    +H +P  W +PE +
Sbjct: 381 LTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVY 440

Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
            P RF  +N     P  + PF +GPRNCIG  FA+  MK+ L  +L +F F P   T+  
Sbjct: 441 DPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP-DHTEPR 499

Query: 475 LKLSLGGLLQPEKPVVLKVE 494
            KL L  +++ E  + L+VE
Sbjct: 500 RKLEL--IMRAEGGLWLRVE 517


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  154 bits (390), Expect = 1e-37
 Identities = 113/409 (27%), Positives = 203/409 (49%), Gaps = 33/409 (8%)

Query: 80  PVLAITDPDMIKTVLVKECYSVFTNR-----RPFGPVGFMKSAISIAEDEEWKRLRSLLS 134
           P++ +  PD++++V+        T++     +   P  ++   + ++  ++W+  R LL+
Sbjct: 97  PIINLCHPDIVRSVI--NTSDAITDKDIVFYKTLKP--WLGDGLLLSVGDKWRHHRRLLT 152

Query: 135 PTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV-NI 193
           P F    LK  + I ++  +++    +R A  G   T  DVF   S+  + S    + + 
Sbjct: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS--TCLDVFEHISLMTLDSLQKCIFSF 210

Query: 194 DSLNNPQDPFVENTKKLLRFDFL-----DPFFLSITVFPFLIPILEVLN-ICVFPREVTN 247
           DS  N Q+   E    ++    L     + FF       FL P     +  C    + T+
Sbjct: 211 DS--NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTD 268

Query: 248 FLRKSVKRMKESRLED------TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301
            + +  +R   S+  D       +   +DF+ +++ S    E ++ K LSD ++ A++  
Sbjct: 269 AVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLS----EDKNGKELSDEDIRAEADT 324

Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEYLDMV 359
           F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + Q+ +L M 
Sbjct: 325 FMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMC 384

Query: 360 VNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
           + E+LRL P      R C +DV + +   IPKG V  I  +A+H +P  W +PE + P R
Sbjct: 385 LKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFR 444

Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
           F  +N     P  + PF +GPRNCIG +FA+  MK+ L   L  F   P
Sbjct: 445 FDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  153 bits (387), Expect = 3e-37
 Identities = 118/433 (27%), Positives = 212/433 (48%), Gaps = 30/433 (6%)

Query: 80  PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----SAISIAEDEEWKRLRSLLSP 135
           P+L +  PD IK +L     ++      F   GF+K      + +++ ++W R R LL+P
Sbjct: 105 PLLVLVHPDYIKPLLGASA-AIAPKDDLF--YGFLKPWLGDGLLLSKGDKWSRHRRLLTP 161

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM---DVITSTSFGVN 192
            F    LK  + I  Q  D++    R  AE G  V+L D+F   S+   D +    F  N
Sbjct: 162 AFHFDILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL-DMFEHISLMTLDSLQKCVFSYN 219

Query: 193 IDSLNNPQD---PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV----FPREV 245
            +      D     +E +   +R  +    +L   ++            C     F  EV
Sbjct: 220 SNCQEKMSDYISAIIELSALSVRRQYRLHHYLDF-IYYRSADGRRFRQACDMVHHFTTEV 278

Query: 246 TNFLRKSVKRM-KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304
               R+++++   E+ L+  Q   +DF+ +++ +++    E  K LSD ++ A++  F+F
Sbjct: 279 IQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMF 334

Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEYLDMVVNE 362
            G++TTSS +S++++ LA +P+ Q+K +EEI  V+  +      +D + Q+ +  M + E
Sbjct: 335 EGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKE 394

Query: 363 TLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421
           +LR +P    + R C +D+++ +G  IPKG++ ++  Y  H +P  W + + + P RF  
Sbjct: 395 SLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDP 454

Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG 481
            N     P  Y PF +GPRNCIG  FA+  +++ +   L  F     +  ++  K  L  
Sbjct: 455 DNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPEL-- 512

Query: 482 LLQPEKPVVLKVE 494
           +L+ E  + LKVE
Sbjct: 513 ILRTENGLWLKVE 525


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  152 bits (385), Expect = 5e-37
 Identities = 112/417 (26%), Positives = 202/417 (48%), Gaps = 49/417 (11%)

Query: 80  PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----SAISIAEDEEWKRLRSLLSP 135
           P+L +  PD+I+ +      +V      F   GF+K      + ++  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKDVFGAYSMDVITSTSFGVNID 194
            F    LK  + I  +  +++    +R A  G   + + +     ++D +    F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQD---------PFVE--NTKKLLRFDFLDPFFLSIT----------VFPFLIPIL 233
               P +          FVE  N + LL  DFL  ++L+            V  F   ++
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFL--YYLTPDGQRFRRACHLVHDFTDAVI 271

Query: 234 EVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDL 293
           +     +  + + +FL+   K              +DF+ +++ S++    E  K LSD 
Sbjct: 272 QERRCTLPTQGIDDFLKNKAK-----------SKTLDFIDVLLLSKD----EDGKELSDE 316

Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVL 351
           ++ A++  F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + 
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLA 376

Query: 352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTE 410
           Q+ +L M + E+LRL P    + R C +D  + +G  IPKG+V +I    +H +P  W +
Sbjct: 377 QLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPD 436

Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
           PE + P RF ++N     P  + PF +GPRNCIG  FA+  MK+ L   L +F   P
Sbjct: 437 PEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  152 bits (385), Expect = 5e-37
 Identities = 112/417 (26%), Positives = 202/417 (48%), Gaps = 49/417 (11%)

Query: 80  PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----SAISIAEDEEWKRLRSLLSP 135
           P+L +  PD+I+ +      +V      F   GF+K      + ++  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VTLKDVFGAYSMDVITSTSFGVNID 194
            F    LK  + I  +  +++    +R A  G   + + +     ++D +    F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQD---------PFVE--NTKKLLRFDFLDPFFLSIT----------VFPFLIPIL 233
               P +          FVE  N + LL  DFL  ++L+            V  F   ++
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFL--YYLTPDGQRFRRACHLVHDFTDAVI 271

Query: 234 EVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDL 293
           +     +  + + +FL+   K              +DF+ +++ S++    E  K LSD 
Sbjct: 272 QERRCTLPTQGIDDFLKNKAK-----------SKTLDFIDVLLLSKD----EDGKELSDE 316

Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVL 351
           ++ A++  F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + 
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLA 376

Query: 352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTE 410
           Q+ +L M + E+LRL P    + R C +D  + +G  IPKG+V +I    +H +P  W +
Sbjct: 377 QLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPD 436

Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
           PE + P RF ++N     P  + PF +GPRNCIG  FA+  MK+ L   L +F   P
Sbjct: 437 PEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  150 bits (379), Expect = 3e-36
 Identities = 132/484 (27%), Positives = 224/484 (46%), Gaps = 37/484 (7%)

Query: 13  LLLAVSLVLLYLYGTHSHGLFKKLG-IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV 71
           LLL +  V LYL   H   L K L   P P      G+I    +     D E  +    V
Sbjct: 28  LLLLIKAVQLYL---HRQWLLKALQQFPCPPSHWLFGHIQELQQ-----DQELQRIQKWV 79

Query: 72  WGFYD-------GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP-VGFMKSAISIAED 123
             F         G +  + + DPD +K +L +       + R   P +G+    + +   
Sbjct: 80  ETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGY---GLLLLNG 136

Query: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
           + W + R +L+P F    LK  V ++A    V++           P+ +       ++D 
Sbjct: 137 QTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDT 196

Query: 184 ITSTSFG----VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC 239
           I   +F     + +D  +      + +   L+     + F  + T++            C
Sbjct: 197 IMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC 256

Query: 240 VFPREVTNF---LRKSVKRMKESRLEDTQKHR-VDFLQLMIDSQNSKETESHKALSDLEL 295
               + T+    LRK+ +  KE  LE  ++ R +DFL +++ ++     E+   LSD +L
Sbjct: 257 QLAHQHTDQVIQLRKA-QLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDL 311

Query: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355
            A+   F+F G++TT+S +S+I+Y LATHP  Q++ +EEI ++L + A  T++ + QM Y
Sbjct: 312 RAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPY 371

Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414
             M + E LRL+P    + R     V   +G  +PKG++V++  Y LH +PK W  PE F
Sbjct: 372 TTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVF 431

Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
            P RF+  +  +   + + PF  G RNCIG +FA+  +K+A    L  F   P   T+IP
Sbjct: 432 DPFRFAPGSAQH--SHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIP 488

Query: 475 LKLS 478
           + ++
Sbjct: 489 IPIA 492


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  149 bits (375), Expect = 8e-36
 Identities = 97/371 (26%), Positives = 186/371 (50%), Gaps = 23/371 (6%)

Query: 120 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY 179
           + E  +W + R LL+P F    LK  V +  +   +++     +A  GK   +    G  
Sbjct: 128 VLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHM 187

Query: 180 SMDVITSTSFGVNIDSLNNPQDPF---------VENTKKLLRFDFLDPFFLSITVFPFLI 230
           +++ +   +FG     L + +D           +   ++L+ F + + F   +T      
Sbjct: 188 ALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHG--- 244

Query: 231 PILEVLNICVFPREVTNFL---RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESH 287
                L  C    + T+ +   RK+  + ++ R +   +  +DFL +++ +++  + +  
Sbjct: 245 --RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK-- 300

Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347
             LSD +L A+   F+F G++TT+S +S+ +Y +A +P+ Q + +EE+  +L ++    +
Sbjct: 301 --LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQW 358

Query: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE-INGMFIPKGVVVMIPSYALHRDPK 406
           D + +M YL M + E+ RL+P   ++ R   K V  ++G  +P G ++ +  YALHR+  
Sbjct: 359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418

Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466
            W +PE F   RFS +N     P+ + PF +GPRNCIG +FA+  MK+     L  F F 
Sbjct: 419 VWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS 478

Query: 467 PCKETQIPLKL 477
               +++P+K+
Sbjct: 479 -LDPSRLPIKM 488


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  148 bits (374), Expect = 1e-35
 Identities = 129/484 (26%), Positives = 224/484 (46%), Gaps = 37/484 (7%)

Query: 13  LLLAVSLVLLYLYGTHSHGLFKKLG-IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV 71
           LLL +    LYL   H   L K L   P P      G+I  +       D E  +   +V
Sbjct: 28  LLLLIKAAQLYL---HRQWLLKALQQFPCPPSHWLFGHIQEFQH-----DQELQRIQERV 79

Query: 72  WGFYD-------GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP-VGFMKSAISIAED 123
             F         G +  + + DPD +K +L +       + +   P +G+    + +   
Sbjct: 80  KTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGY---GLLLLNG 136

Query: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
           + W + R +L+P F +  LK  V ++A    V++           P+ +       ++D 
Sbjct: 137 QTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDT 196

Query: 184 ITSTSFG----VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC 239
           I  ++F     + +D  +      + +   L+     + F  + T++            C
Sbjct: 197 IMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRAC 256

Query: 240 VFPREVTNF---LRKSVKRMKESRLEDTQKHR-VDFLQLMIDSQNSKETESHKALSDLEL 295
               + T+    LRK+ +  KE  LE  ++ R +DFL +++ ++     E+   LSD +L
Sbjct: 257 QLAHQHTDQVIQLRKA-QLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDL 311

Query: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355
            A+   F+F G++TT+S +S+I+Y LATHP  Q++ +EEI  +L + A  T++ + QM Y
Sbjct: 312 RAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPY 371

Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414
             M + E LRL+P    + R     V   +G  +PKG++V++  Y LH +PK W   E F
Sbjct: 372 TTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVF 431

Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
            P RF+  +  +   + + PF  G RNCIG +FA+  +K+A    L  F   P   T+IP
Sbjct: 432 DPSRFAPGSAQH--SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIP 488

Query: 475 LKLS 478
           + ++
Sbjct: 489 IPMA 492


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  148 bits (373), Expect = 1e-35
 Identities = 96/370 (25%), Positives = 185/370 (50%), Gaps = 22/370 (5%)

Query: 120 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY 179
           + E  +W + R LL+P F    LK  V +  +   +++     +A  GK   +    G  
Sbjct: 128 VLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHM 187

Query: 180 SMDVITSTSFGVNIDSLNNPQDPF--------VENTKKLLRFDFLDPFFLSITVFPFLIP 231
           +++ +   +FG     L +    +        +   ++L+ F + + F   +T       
Sbjct: 188 ALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHG---- 243

Query: 232 ILEVLNICVFPREVTNFL---RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK 288
               L  C    + T+ +   RK+  + ++ R +   +  +DFL +++ +++  + +   
Sbjct: 244 -RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK--- 299

Query: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348
            LSD +L A+   F+F G++TT+S +S+ +Y +A +P+ Q + +EE+  +L ++    +D
Sbjct: 300 -LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 358

Query: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE-INGMFIPKGVVVMIPSYALHRDPKY 407
            + +M YL M + E+ RL+P   ++ R   K V  ++G  +P G ++ +  YALHR+   
Sbjct: 359 DLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV 418

Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
           W +PE F   RFS +N     P+ + PF +GPRNCIG +FA+  MK+     L  F F  
Sbjct: 419 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS- 477

Query: 468 CKETQIPLKL 477
              +++P+K+
Sbjct: 478 LDPSRLPIKM 487


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  147 bits (371), Expect = 2e-35
 Identities = 99/371 (26%), Positives = 179/371 (48%), Gaps = 24/371 (6%)

Query: 113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-VT 171
           ++   + ++  E+W R R +L+P F    LK  + I  +  +++    +  A  G   + 
Sbjct: 131 WLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLD 190

Query: 172 LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL-----DPFFLSITVF 226
           + +     ++D +    F  +      P     E    +L    L         L I   
Sbjct: 191 MFEHISLMTLDSLQKCVFSFDSHCQEKPS----EYIAAILELSALVTKRHQQILLYIDFL 246

Query: 227 PFLIPILEVLN-ICVFPREVTNFLRKSVKRMKESRLED------TQKHRVDFLQLMIDSQ 279
            +L P  +     C    + T+ + +  +R   S+  D       +   +DF+ +++ S+
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSK 306

Query: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339
           +    E  K LSD ++ A++  F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L
Sbjct: 307 D----EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362

Query: 340 PNKAPPT--YDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMI 396
            ++ P    +D + Q+ +L M + E+LRL P    + R C +D+ + +G  IPKG++ +I
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422

Query: 397 PSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456
             +  H +P  W +PE + P RF  KN     P  + PF +GPRNCIG  FA+  MK+ L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482

Query: 457 IRVLQNFSFKP 467
              L  F   P
Sbjct: 483 GLTLLRFRVLP 493


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  146 bits (368), Expect = 5e-35
 Identities = 126/508 (24%), Positives = 237/508 (46%), Gaps = 42/508 (8%)

Query: 7   LAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPT-PLPFLGNILSYHK-----GFCMF 60
           L + + +LLA  L   +++   S    +   IPGP  P   LG++  + K     G  + 
Sbjct: 6   LLLGSAVLLAFGLCCTFVHRARS----RYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQ 61

Query: 61  D--MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTN-----RRPFGPVGF 113
           D  ++  KKYG V       +  + +T P+ +K  L+   Y+  +      +  FG   F
Sbjct: 62  DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 121

Query: 114 MKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLK 173
            +  +S    E W + R ++   F+   L  ++    +  + LV  L  +A+   PV+++
Sbjct: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181

Query: 174 DVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP-- 231
           D+    +MD++   +FG+    L   Q P  +  K +L     +    S       +P  
Sbjct: 182 DMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLML-----EGITASRNTLAKFLPGK 236

Query: 232 ---ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK 288
              + EV     F R+V    R  V+R +E+ L+  ++   D L  ++ ++         
Sbjct: 237 RKQLREVRESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG------- 285

Query: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348
           A  D  L+   + F  AG+ET+++ L+F + EL+  P++  +LQ E+D V+ +K    ++
Sbjct: 286 AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE 345

Query: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408
            + +++YL  V+ E+LRL+P A    R+ +++  I+G+ +P    ++  +Y + R   Y+
Sbjct: 346 DLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF 405

Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 468
            +P  F P+RF          + Y PF  G R+CIG +FA M +K+ + ++LQ   F+  
Sbjct: 406 EDPLTFNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463

Query: 469 KETQIPLKLSLGGLLQPEKPVVLKVESR 496
              +  L+      L+P  PV+  +  R
Sbjct: 464 PGQRFGLQEQ--ATLKPLDPVLCTLRPR 489


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  142 bits (357), Expect = 9e-34
 Identities = 106/405 (26%), Positives = 198/405 (48%), Gaps = 25/405 (6%)

Query: 80  PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG-FMKSAISIAEDEEWKRLRSLLSPTFT 138
           P+L++  PD+I++V+         ++  +  +  ++   + ++  ++W R R +L+P F 
Sbjct: 97  PLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFH 156

Query: 139 SGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV-NIDSLN 197
              LK  + I  +  +++    +  A  G      D+F   S+  + S    V + DS  
Sbjct: 157 FNILKPYMKIFNESVNIMHAKWQLLASEGSACL--DMFEHISLMTLDSLQKCVFSFDS-- 212

Query: 198 NPQDPFVENTKKLLRFDFL-----DPFFLSITVFPFLIPILEVLN-ICVFPREVTNFLRK 251
           + Q+   E    +L    L         L I    +L P  +     C    + T+ + +
Sbjct: 213 HCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQ 272

Query: 252 SVKRMKESRLED------TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305
             +R   S+  D       +   +DF+ +++ S++    E  K LSD ++ A++  F+F 
Sbjct: 273 ERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD----EDGKKLSDEDIRAEADTFMFE 328

Query: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEYLDMVVNET 363
           G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D +  + +L M + E+
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 364 LRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422
           LRL P    + R   +D+ + +G  IPKG++ +I  +  H +P  W +PE + P RF  +
Sbjct: 389 LRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPE 448

Query: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
           N     P  + PF +GPRNCIG  FA+  MK+ L   L  F   P
Sbjct: 449 NIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP 493


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  140 bits (352), Expect = 4e-33
 Identities = 133/493 (26%), Positives = 220/493 (44%), Gaps = 58/493 (11%)

Query: 38  IPGPTPLPFLGNILSYHKGFCMFDMECH--KKYGKVWGFYDGQQPVLAITDPDMIKTVLV 95
           IPGP+   FL  +        + +++      +G VW    G    + +  P +++ +L 
Sbjct: 40  IPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLR 99

Query: 96  KE-------CYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPI 148
           +E        +S +T  R           +  AE EEW+RLRSLL+P     +       
Sbjct: 100 QEGPRPERCSFSPWTEHRRCRQ---RACGLLTAEGEEWQRLRSLLAPLLLRPQAA----- 151

Query: 149 IAQYGDVL-------VRNLRREAE--TGKPVTLKDVFGAY---SMDVITSTSFGVNIDSL 196
            A+Y   L       VR LRR+    TG P  ++DV G +    ++ I +   G  +  L
Sbjct: 152 -ARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCL 210

Query: 197 NNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL--NICVFPREVTNFLRKSVK 254
                P  E   + +   F+    L++ +  +L  ++      +C    ++  F ++ V+
Sbjct: 211 EAQVPPDTETFIRAVGSVFVSTL-LTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVE 269

Query: 255 RMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDL----ELVAQSII-----FIFA 305
           R +                +    Q  K+ ES   L+      EL AQSI+      + A
Sbjct: 270 RREAEAA------------MRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLA 317

Query: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP--NKAPPTYDTVLQMEYLDMVVNET 363
           G +T S+ LS+ +YEL+ HP+VQ  L  EI A L   + A P+   + Q+  L  VV E 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423
           LRL+P+     RV  KD+ +    IPK  +V +  YA  RDP  + EP  F P R+  + 
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483
                P+   PFG G R+C+G R A + +++AL ++L +F  +P +    P++     +L
Sbjct: 438 -PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP-EPGAAPVRPKTRTVL 495

Query: 484 QPEKPVVLKVESR 496
            PE+ + L+   R
Sbjct: 496 VPERSINLQFLDR 508


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  136 bits (343), Expect = 4e-32
 Identities = 122/498 (24%), Positives = 218/498 (43%), Gaps = 54/498 (10%)

Query: 39  PGPTPLPFLGNI--------------LSYHKGFCMFD----------MECHKKYGKVWGF 74
           PGPTP P +GN               LS        D              + YG ++ F
Sbjct: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 75  YDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM---KSAISIAEDEEWKRLRS 131
           + G   V+ ++D   ++  LV++   VF++R     +  +   K  +       W++ R 
Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQA-EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRK 179

Query: 132 LLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188
               T   F  GKL     II ++  V     +   +   P ++  +  A S ++I S  
Sbjct: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI--ISNAVS-NIICSLC 236

Query: 189 FGVNIDSLNNPQDPFVENTKKLLRFDF------LDPFFLSITVFPFL--IPILEVLNICV 240
           FG   D  N+         KK+L F        L+   L + + P+L  +P      +  
Sbjct: 237 FGQRFDYTNS-------EFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQ 289

Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
             +++T+FL+K +K  +ES   +  +  +D   L ++ +    + S     D E +   I
Sbjct: 290 IEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS---FDEEYLFYII 346

Query: 301 IFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359
             +F AG +TT++ L + +  ++ +PDVQ+K+ EEI+ V+     P+     QM Y +  
Sbjct: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEAT 406

Query: 360 VNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
           + E  RL  +  + +  +  ++  + G  IPKG +++   +++HRDP  W +PE F P R
Sbjct: 407 IMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNR 466

Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478
           F       I    + PFG G R C+G + A M + L  + ++Q+F+F   ++++ PL   
Sbjct: 467 FLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTG 526

Query: 479 LGGLLQPEKPVVLKVESR 496
             GL     P  + +  R
Sbjct: 527 RFGLTLAPHPFNITISRR 544


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  131 bits (329), Expect = 2e-30
 Identities = 118/463 (25%), Positives = 200/463 (43%), Gaps = 32/463 (6%)

Query: 39  PGPTPLPFLGNILSYHKGFCMFDMECH-KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97
           PGP  LPFLGN           +++   KKYG ++    G    + IT   +IK  L+  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHM 104

Query: 98  CYSVFTNRRPFGPVG---FMKSAISIAEDEEWKRLRSLLSPT---FTSGK--LKEMVPII 149
             +     RP  P+    F K+ + ++  + WK  R         F  GK  L+E +   
Sbjct: 105 DQNF--GNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEE 162

Query: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209
           AQ+    ++      E G+P            ++I S +FG   +     QD + +   K
Sbjct: 163 AQHLTEAIKE-----ENGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLK 213

Query: 210 LLRFDFLDPFFLSIT-----VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDT 264
           LL  D +     S T     VFP+++  L   +  +F       L+  V  M +   +D 
Sbjct: 214 LL--DEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSN--WKKLKLFVSHMIDKHRKDW 269

Query: 265 QKHRV-DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323
                 DF+   +   +        +  +  L+  ++   FAG ETTS+ L + +  +A 
Sbjct: 270 NPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMAL 329

Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVE 382
           +P++Q+K+Q EID V+     P+      M Y + V++E  R+   I + + R    D  
Sbjct: 330 YPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTT 389

Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
           + G  +PKG +++    ALHRDP  W  P+ F P+ F  +N        + PF  G R C
Sbjct: 390 LAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRAC 448

Query: 443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP 485
           +G + A   + +    ++Q F+F+P    ++ LK  +G  + P
Sbjct: 449 LGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISP 491


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  129 bits (325), Expect = 5e-30
 Identities = 124/472 (26%), Positives = 214/472 (45%), Gaps = 46/472 (9%)

Query: 38  IPGPTPLPFLGNILSY-HKGFCMFD----MECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
           +PGPT  P LG++L    KG         +E HKKYGK++    G    + +  P +++ 
Sbjct: 58  LPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEA 117

Query: 93  VLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEMV 146
           +   E  S +  R    P    +        + I E E+W+R+RS         K  E++
Sbjct: 118 LYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPGEVM 173

Query: 147 PIIAQYGDVLVRNLRREAET----GKPVTLKDVFGAYSMD----VITSTSFGVNIDSLNN 198
            +  +  +VL   + R  E     G    L      +S +    V+    FG+   +  +
Sbjct: 174 KLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD 233

Query: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--LRKSVKRM 256
               F+   K ++        F  + V P  + + + LN  V+      +  + KSVK  
Sbjct: 234 EAVNFIMAIKTMMST------FGRMMVTP--VELHKSLNTKVWQDHTLAWDTIFKSVKAC 285

Query: 257 KESRLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315
            ++RLE  +Q+   DFL  +       + E + A+++L+L A          ETT++ L 
Sbjct: 286 IDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA---------VETTANSLM 336

Query: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375
           +I+Y L+ +P VQQKL +EI +VLP    P  + +  M YL   + E++RL P      R
Sbjct: 337 WILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396

Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435
              K   +    +PKG V+M+ +  L      + +  +F PER+ ++ K+ I+P+ + PF
Sbjct: 397 TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE-KEKINPFAHLPF 455

Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK 487
           G G R CIG R A + + LAL  +++ +  +       P+++   G L P +
Sbjct: 456 GVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE--PVEMLHSGTLVPSR 505


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  128 bits (321), Expect = 1e-29
 Identities = 132/483 (27%), Positives = 204/483 (42%), Gaps = 59/483 (12%)

Query: 13  LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKV 71
           L+L +S +LL      S G  K    PGPTPLP +GNIL    K          K YG V
Sbjct: 7   LVLCLSCLLLLSLWRQSSGRGKLP--PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64

Query: 72  WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRL 129
           +  Y G +P++ +   + +K  L+ +    F+ R   P          I  +  ++WK +
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123

Query: 130 RSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
           R     T   F  GK + +   + +    LV  LR+   +  P     + G    +VI S
Sbjct: 124 RRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKAS--PCDPTFILGCAPCNVICS 180

Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI------TVFPFLIPILEVLN--- 237
             F                      RFD+ D  FL++       +     P +++ N   
Sbjct: 181 IIFHK--------------------RFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220

Query: 238 --ICVFPREVTNFLRKSVKRMKESRLEDTQKHRV--------DFLQLMIDSQNSKETESH 287
             I  FP    N L K+V  MK   LE  ++H+         DF+   +  +  KE  + 
Sbjct: 221 PIIDYFPG-THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQ 278

Query: 288 KALSDLELVAQSIIFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 346
            +   +E +  + + +F AG ETTS+ L + +  L  HP+V  K+QEEI+ V+     P 
Sbjct: 279 PSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC 338

Query: 347 YDTVLQMEYLDMVVNETLR---LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR 403
                 M Y D VV+E  R   L P ++     C  D++     IPKG  ++I   ++  
Sbjct: 339 MQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILISLTSVLH 396

Query: 404 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
           D K +  PE F P  F  +  +      + PF +G R C+G   A M + L L  +LQNF
Sbjct: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456

Query: 464 SFK 466
           + K
Sbjct: 457 NLK 459


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  127 bits (320), Expect = 2e-29
 Identities = 122/475 (25%), Positives = 204/475 (42%), Gaps = 31/475 (6%)

Query: 39  PGPTPLPFLGNILSYHKGFCMFDMECHKK---YGKVWGFYDGQQPVLAITDPDMIKTVLV 95
           PGP  LPF+GNI S      +  +   K+   YG+++    G    + +   D++K  LV
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100

Query: 96  KECYSVFTNRRPFGPVGFMKSA-----ISIAEDEEWKRLRSLLSPTFTS---GKLKEMVP 147
            +   +F +R P  P+ FMK       ++      W   R L   +F     G+      
Sbjct: 101 HQS-EIFADR-PCLPL-FMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157

Query: 148 IIAQ---YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 204
           I+ +   + D +      E   G+P   K +      ++     FG      +      +
Sbjct: 158 ILEETKFFNDAI------ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211

Query: 205 ENTKKLLRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262
           E   + +        FL    FP++  +P  +   +      V +FL + +++   +R  
Sbjct: 212 ELFSENVELAASASVFL-YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270

Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322
              +H VD     +D  +  + +     S   L+      I AG ETT++VL + +  +A
Sbjct: 271 QLPQHFVD---AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327

Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDV 381
            +P++Q ++Q+EID ++     P++D   +M Y + V++E LR   I  + +     +D 
Sbjct: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDA 387

Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
            + G  IPKG  V+   Y++H D KYW +PE F PERF   +          PF  G R+
Sbjct: 388 VVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRH 447

Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
           C+G   A M M L    +LQ F      E    LK  LG  LQP+ P ++  E R
Sbjct: 448 CLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ-PYLICAERR 501


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,802,427
Number of Sequences: 37866
Number of extensions: 838189
Number of successful extensions: 2083
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1840
Number of HSP's gapped (non-prelim): 117
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.