Search of human proteins with 6005997

Search of human proteins with 6005997

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6005997 double C2-like domains, beta [Homo sapiens]
         (412 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6005997 double C2-like domains, beta [Homo sapiens]                855   0.0  
gi|47078261 double C2-like domains, alpha [Homo sapiens]              498   e-141
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]            490   e-139
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]             490   e-139
gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo sap...   365   e-101
gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]            191   1e-48
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]            191   1e-48
gi|211059429 synaptotagmin II [Homo sapiens]                          186   3e-47
gi|31543670 synaptotagmin II [Homo sapiens]                           186   3e-47
gi|209447073 synaptotagmin I [Homo sapiens]                           184   2e-46
gi|5032139 synaptotagmin I [Homo sapiens]                             184   2e-46
gi|209447070 synaptotagmin I [Homo sapiens]                           184   2e-46
gi|38570146 synaptotagmin VII [Homo sapiens]                          176   5e-44
gi|92859638 synaptotagmin V [Homo sapiens]                            172   7e-43
gi|216548478 synaptotagmin XI [Homo sapiens]                          167   2e-41
gi|24308219 synaptotagmin IV [Homo sapiens]                           165   8e-41
gi|39752671 synaptotagmin X [Homo sapiens]                            164   1e-40
gi|45504376 synaptotagmin VI [Homo sapiens]                           163   2e-40
gi|238550198 synaptotagmin III [Homo sapiens]                         143   2e-34
gi|238550196 synaptotagmin III [Homo sapiens]                         143   2e-34
gi|14150054 synaptotagmin III [Homo sapiens]                          143   2e-34
gi|193804862 synaptotagmin-like 4 [Homo sapiens]                      139   6e-33
gi|193804860 synaptotagmin-like 4 [Homo sapiens]                      139   6e-33
gi|28376627 synaptotagmin IX [Homo sapiens]                           136   3e-32
gi|40068038 B/K protein [Homo sapiens]                                125   9e-29
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]            117   1e-26
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]            117   1e-26
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]             117   1e-26
gi|94536846 synaptotagmin VIII [Homo sapiens]                         115   6e-26
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]             107   3e-23

>gi|6005997 double C2-like domains, beta [Homo sapiens]
          Length = 412

 Score =  855 bits (2209), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA 60
           MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
Sbjct: 1   MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA 60

Query: 61  RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE 120
           RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
Sbjct: 61  RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE 120

Query: 121 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL 180
           SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
Sbjct: 121 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL 180

Query: 181 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP 240
           RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
Sbjct: 181 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP 240

Query: 241 NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG 300
           NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG
Sbjct: 241 NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG 300

Query: 301 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI 360
           YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI
Sbjct: 301 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI 360

Query: 361 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD 412
           GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
Sbjct: 361 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD 412


>gi|47078261 double C2-like domains, alpha [Homo sapiens]
          Length = 400

 Score =  498 bits (1281), Expect = e-141
 Identities = 259/426 (60%), Positives = 292/426 (68%), Gaps = 58/426 (13%)

Query: 5   RRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAV 64
           RRG++ TI+IQEHMAI+VCPGPIRPI+QISDYFPR P    P+ G        A   P  
Sbjct: 4   RRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPG---PEGGGGGGGEAPAHLVPLA 60

Query: 65  AGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDC 124
                                              P  A   A  PED  + D Y+SDD 
Sbjct: 61  LA---------------------------------PPAALLGATTPEDGAEVDSYDSDDA 87

Query: 125 TALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKT 184
           TALGTL+F LLYD+ +  LHC+I +AKGLKPMD NGLADPYVKLHLLPGA KANKL+TKT
Sbjct: 88  TALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKT 147

Query: 185 LRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTK 244
            RNTLNP WNE LTY GITD+D+  K LRI+VCDEDK  HNEFIGE RVPL++LKP+  K
Sbjct: 148 QRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKK 207

Query: 245 TFNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSSQKQG 282
            FNICLE+Q+P+      S                      LEERGRIL+SL YSS+++G
Sbjct: 208 HFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRG 267

Query: 283 LLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIK 342
           LLVGI+RCAHLAAMD NGYSDPYVKTYLRPDVDKKSKHKT VKKKTLNPEFNEEF YEI+
Sbjct: 268 LLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIE 327

Query: 343 HGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLT 402
              LA K+LEVTVWDYDIGKSNDFIGGV LG  A+GE  KHW DCL+  D  +ERWHTLT
Sbjct: 328 LSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLT 387

Query: 403 SELPGA 408
           SELP A
Sbjct: 388 SELPPA 393


>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
          Length = 694

 Score =  490 bits (1262), Expect = e-139
 Identities = 246/386 (63%), Positives = 290/386 (75%), Gaps = 25/386 (6%)

Query: 41  PRGLPPDAGPRAAAPPD----APARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGP 96
           P G  PD  P  A P D    AP R    G     P+ GARED   +    G Y  +   
Sbjct: 306 PAGRFPDQKPEVA-PSDPGTTAPPREERTGGVGGYPAVGAREDR--MSHPSGPYSQASAA 362

Query: 97  SPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPM 156
           +P P+ AR P  P E+E +A+ Y+SD+ T LG L+FSLLYDQ+N++L CTI KAKGLKPM
Sbjct: 363 APQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPM 422

Query: 157 DHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISV 216
           D NGLADPYVKLHLLPGASK+NKLRTKTLRNT NP WNETL Y+GITDEDM RKTLRISV
Sbjct: 423 DSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISV 482

Query: 217 CDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPVDKT------------EDK-- 262
           CDEDKF HNEFIGETR  LKKLKPN  K FNICLE+ +P+ +             E++  
Sbjct: 483 CDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQV 542

Query: 263 ----SLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKS 318
                +EERG+IL+SL YS+Q+ GL+VGI+RC HLAAMDANGYSDP+VK +L+PD+ KK+
Sbjct: 543 ERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKA 602

Query: 319 KHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKG 378
           KHKT +KKKTLNPEFNEEF Y+IKH DLAKKSL+++VWDYDIGKSND+IGG  LGI AKG
Sbjct: 603 KHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKG 662

Query: 379 ERLKHWFDCLKNKDKRIERWHTLTSE 404
           ERLKHW++CLKNKDK+IERWH L +E
Sbjct: 663 ERLKHWYECLKNKDKKIERWHQLQNE 688



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 20/76 (26%), Positives = 26/76 (34%), Gaps = 1/76 (1%)

Query: 36  YFPRFPRGLPPDAGPRAAAPPDAP-ARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSP 94
           +F  FP+ + P   P     P  P + PA        P   AR       +     G   
Sbjct: 157 FFKGFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKT 216

Query: 95  GPSPGPSPARPPAKPP 110
           GP P  +P R    PP
Sbjct: 217 GPDPASAPGRGNYGPP 232


>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
          Length = 690

 Score =  490 bits (1262), Expect = e-139
 Identities = 246/386 (63%), Positives = 290/386 (75%), Gaps = 25/386 (6%)

Query: 41  PRGLPPDAGPRAAAPPD----APARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGP 96
           P G  PD  P  A P D    AP R    G     P+ GARED   +    G Y  +   
Sbjct: 302 PAGRFPDQKPEVA-PSDPGTTAPPREERTGGVGGYPAVGAREDR--MSHPSGPYSQASAA 358

Query: 97  SPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPM 156
           +P P+ AR P  P E+E +A+ Y+SD+ T LG L+FSLLYDQ+N++L CTI KAKGLKPM
Sbjct: 359 APQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPM 418

Query: 157 DHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISV 216
           D NGLADPYVKLHLLPGASK+NKLRTKTLRNT NP WNETL Y+GITDEDM RKTLRISV
Sbjct: 419 DSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISV 478

Query: 217 CDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPVDKT------------EDK-- 262
           CDEDKF HNEFIGETR  LKKLKPN  K FNICLE+ +P+ +             E++  
Sbjct: 479 CDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQV 538

Query: 263 ----SLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKS 318
                +EERG+IL+SL YS+Q+ GL+VGI+RC HLAAMDANGYSDP+VK +L+PD+ KK+
Sbjct: 539 ERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKA 598

Query: 319 KHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKG 378
           KHKT +KKKTLNPEFNEEF Y+IKH DLAKKSL+++VWDYDIGKSND+IGG  LGI AKG
Sbjct: 599 KHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKG 658

Query: 379 ERLKHWFDCLKNKDKRIERWHTLTSE 404
           ERLKHW++CLKNKDK+IERWH L +E
Sbjct: 659 ERLKHWYECLKNKDKKIERWHQLQNE 684



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 20/76 (26%), Positives = 26/76 (34%), Gaps = 1/76 (1%)

Query: 36  YFPRFPRGLPPDAGPRAAAPPDAP-ARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSP 94
           +F  FP+ + P   P     P  P + PA        P   AR       +     G   
Sbjct: 153 FFKGFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKT 212

Query: 95  GPSPGPSPARPPAKPP 110
           GP P  +P R    PP
Sbjct: 213 GPDPASAPGRGNYGPP 228


>gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
           sapiens]
          Length = 431

 Score =  365 bits (937), Expect = e-101
 Identities = 203/408 (49%), Positives = 262/408 (64%), Gaps = 55/408 (13%)

Query: 7   GEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAG 66
           G+   +S+QEHMAIDV PGPIRPI+ IS YFP F     P A P A  PP+   RPA A 
Sbjct: 63  GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFY----PFAEP-ALHPPNL--RPAAAS 115

Query: 67  AGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTA 126
           A R +P                                     P+ EP+ D   SDD TA
Sbjct: 116 AVRSAPQ----------------------------------LQPDPEPEGD---SDDSTA 138

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
           LGTL+F+LL++ +N+ALHCT  +AKGLKP+  +G AD YVK +LLPGASKA++LRT T+R
Sbjct: 139 LGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVKANLLPGASKASQLRTHTVR 197

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRI------SVCDEDKFRHNEF----IGETRVPLK 236
            T  P W ETLTY+G T +D   KTLR       +VC        ++    +GE RVPL+
Sbjct: 198 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 257

Query: 237 KLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAM 296
           KL PN  ++F+ICLEK+   +   + + EE G +L+SL YSSQ+ GLLVG++RCAHLA M
Sbjct: 258 KLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPM 317

Query: 297 DANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVW 356
           DANGYSDP+V+ +L P+  KKSK KT+V +KTLNPEFNEEF Y     +LA+K+L V+VW
Sbjct: 318 DANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVW 377

Query: 357 DYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           DYD+G ++DFIGGV LG HA GERL+HW +CL + D R++ WH L S+
Sbjct: 378 DYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPLDSK 425


>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
          Length = 451

 Score =  191 bits (484), Expect = 1e-48
 Identities = 88/140 (62%), Positives = 111/140 (79%)

Query: 265 EERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAV 324
           EE G +L+SL YSSQ+ GLLVG++RCAHLA MDANGYSDP+V+ +L P+  KKSK KT+V
Sbjct: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365

Query: 325 KKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHW 384
            +KTLNPEFNEEF Y     +LA+K+L V+VWDYD+G ++DFIGGV LG HA GERL+HW
Sbjct: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425

Query: 385 FDCLKNKDKRIERWHTLTSE 404
            +CL + D R+E WH L S+
Sbjct: 426 LECLGHSDHRLELWHPLDSK 445



 Score =  184 bits (467), Expect = 1e-46
 Identities = 116/257 (45%), Positives = 148/257 (57%), Gaps = 55/257 (21%)

Query: 7   GEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAG 66
           G+   +S+QEHMAIDV PGPIRPI+ IS YFP F     P A P A  PP+   RPA A 
Sbjct: 9   GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFY----PFAEP-ALHPPNL--RPAAAS 61

Query: 67  AGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTA 126
           A R +P                                     P+ EP+ D   SDD TA
Sbjct: 62  AVRSAPQ----------------------------------LQPDPEPEGD---SDDSTA 84

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
           LGTL+F+LL++ +N+ALHCT  +AKGLKP+  +G AD YVK +LLPGASKA++LRT T+R
Sbjct: 85  LGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVKANLLPGASKASQLRTHTVR 143

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRI------SVCDEDKFRHNEF----IGETRVPLK 236
            T  P W ETLTY+G T +D   KTLR       +VC        ++    +GE RVPL+
Sbjct: 144 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 203

Query: 237 KLKPNHTKTFNICLEKQ 253
           KL PN  ++F+ICLEK+
Sbjct: 204 KLVPNRARSFDICLEKR 220



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 48/136 (35%), Positives = 68/136 (50%), Gaps = 6/136 (4%)

Query: 94  PGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGL 153
           P     P P    A+  E+      +E  +C   G +  SL Y  +   L   + +   L
Sbjct: 280 PRVPSAPDPKHNSARSMEEVETEVAWE--EC---GHVLLSLCYSSQQGGLLVGVLRCAHL 334

Query: 154 KPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLR 213
            PMD NG +DP+V+L L P A K +K +T   R TLNP +NE   Y G   E++ +KTL 
Sbjct: 335 APMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLL 393

Query: 214 ISVCDEDKFRHNEFIG 229
           +SV D D    ++FIG
Sbjct: 394 VSVWDYDLGTADDFIG 409



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 4/64 (6%)

Query: 298 ANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWD 357
           A+G +D YVK  L P   K S+ +T   + T  P + E   Y   HG   ++  E     
Sbjct: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY---HG-FTRQDAECKTLR 170

Query: 358 YDIG 361
            D+G
Sbjct: 171 SDLG 174


>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
          Length = 451

 Score =  191 bits (484), Expect = 1e-48
 Identities = 88/140 (62%), Positives = 111/140 (79%)

Query: 265 EERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAV 324
           EE G +L+SL YSSQ+ GLLVG++RCAHLA MDANGYSDP+V+ +L P+  KKSK KT+V
Sbjct: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365

Query: 325 KKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHW 384
            +KTLNPEFNEEF Y     +LA+K+L V+VWDYD+G ++DFIGGV LG HA GERL+HW
Sbjct: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425

Query: 385 FDCLKNKDKRIERWHTLTSE 404
            +CL + D R+E WH L S+
Sbjct: 426 LECLGHSDHRLELWHPLDSK 445



 Score =  184 bits (467), Expect = 1e-46
 Identities = 116/257 (45%), Positives = 148/257 (57%), Gaps = 55/257 (21%)

Query: 7   GEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAG 66
           G+   +S+QEHMAIDV PGPIRPI+ IS YFP F     P A P A  PP+   RPA A 
Sbjct: 9   GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFY----PFAEP-ALHPPNL--RPAAAS 61

Query: 67  AGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTA 126
           A R +P                                     P+ EP+ D   SDD TA
Sbjct: 62  AVRSAPQ----------------------------------LQPDPEPEGD---SDDSTA 84

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
           LGTL+F+LL++ +N+ALHCT  +AKGLKP+  +G AD YVK +LLPGASKA++LRT T+R
Sbjct: 85  LGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVKANLLPGASKASQLRTHTVR 143

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRI------SVCDEDKFRHNEF----IGETRVPLK 236
            T  P W ETLTY+G T +D   KTLR       +VC        ++    +GE RVPL+
Sbjct: 144 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 203

Query: 237 KLKPNHTKTFNICLEKQ 253
           KL PN  ++F+ICLEK+
Sbjct: 204 KLVPNRARSFDICLEKR 220



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 48/136 (35%), Positives = 68/136 (50%), Gaps = 6/136 (4%)

Query: 94  PGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGL 153
           P     P P    A+  E+      +E  +C   G +  SL Y  +   L   + +   L
Sbjct: 280 PRVPSAPDPKHNSARSMEEVETEVAWE--EC---GHVLLSLCYSSQQGGLLVGVLRCAHL 334

Query: 154 KPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLR 213
            PMD NG +DP+V+L L P A K +K +T   R TLNP +NE   Y G   E++ +KTL 
Sbjct: 335 APMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLL 393

Query: 214 ISVCDEDKFRHNEFIG 229
           +SV D D    ++FIG
Sbjct: 394 VSVWDYDLGTADDFIG 409



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 4/64 (6%)

Query: 298 ANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWD 357
           A+G +D YVK  L P   K S+ +T   + T  P + E   Y   HG   ++  E     
Sbjct: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY---HG-FTRQDAECKTLR 170

Query: 358 YDIG 361
            D+G
Sbjct: 171 SDLG 174


>gi|211059429 synaptotagmin II [Homo sapiens]
          Length = 419

 Score =  186 bits (473), Expect = 3e-47
 Identities = 113/292 (38%), Positives = 159/292 (54%), Gaps = 9/292 (3%)

Query: 113 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP 172
           E + +G E  +   LG L FSL YD + N L   + +A  L  +D  G +DPYVK+ LLP
Sbjct: 126 EGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLP 185

Query: 173 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR 232
              K  K  TK  R TLNP +NET T+  +  +++  KTL +++ D D+F  ++ IGE +
Sbjct: 186 --DKKKKYETKVHRKTLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVK 242

Query: 233 VPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAH 292
           VP+      +T      +E+   +   E +  E+ G I  SL+Y      L V I+   +
Sbjct: 243 VPM------NTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKN 296

Query: 293 LAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLE 352
           L  MD  G SDPYVK +L  +  +  K KT VKKKTLNP FNE F +EI    + K  + 
Sbjct: 297 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVV 356

Query: 353 VTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           VTV DYD    N+ IG + +G +A G  L+HW D L N  + I +WH+L  E
Sbjct: 357 VTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPE 408



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 45/123 (36%), Positives = 67/123 (54%), Gaps = 1/123 (0%)

Query: 108 KPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVK 167
           +P E+  D  G E ++   LG +  SL Y      L   I +AK LK MD  GL+DPYVK
Sbjct: 252 QPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVK 311

Query: 168 LHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEF 227
           +HL+    +  K +T   + TLNP +NE+ + + I  E + +  + ++V D DK   NE 
Sbjct: 312 IHLMQNGKRLKKKKTTVKKKTLNPYFNESFS-FEIPFEQIQKVQVVVTVLDYDKLGKNEA 370

Query: 228 IGE 230
           IG+
Sbjct: 371 IGK 373


>gi|31543670 synaptotagmin II [Homo sapiens]
          Length = 419

 Score =  186 bits (473), Expect = 3e-47
 Identities = 113/292 (38%), Positives = 159/292 (54%), Gaps = 9/292 (3%)

Query: 113 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP 172
           E + +G E  +   LG L FSL YD + N L   + +A  L  +D  G +DPYVK+ LLP
Sbjct: 126 EGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLP 185

Query: 173 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR 232
              K  K  TK  R TLNP +NET T+  +  +++  KTL +++ D D+F  ++ IGE +
Sbjct: 186 --DKKKKYETKVHRKTLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVK 242

Query: 233 VPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAH 292
           VP+      +T      +E+   +   E +  E+ G I  SL+Y      L V I+   +
Sbjct: 243 VPM------NTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKN 296

Query: 293 LAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLE 352
           L  MD  G SDPYVK +L  +  +  K KT VKKKTLNP FNE F +EI    + K  + 
Sbjct: 297 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVV 356

Query: 353 VTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           VTV DYD    N+ IG + +G +A G  L+HW D L N  + I +WH+L  E
Sbjct: 357 VTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPE 408



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 45/123 (36%), Positives = 67/123 (54%), Gaps = 1/123 (0%)

Query: 108 KPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVK 167
           +P E+  D  G E ++   LG +  SL Y      L   I +AK LK MD  GL+DPYVK
Sbjct: 252 QPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVK 311

Query: 168 LHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEF 227
           +HL+    +  K +T   + TLNP +NE+ + + I  E + +  + ++V D DK   NE 
Sbjct: 312 IHLMQNGKRLKKKKTTVKKKTLNPYFNESFS-FEIPFEQIQKVQVVVTVLDYDKLGKNEA 370

Query: 228 IGE 230
           IG+
Sbjct: 371 IGK 373


>gi|209447073 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  184 bits (466), Expect = 2e-46
 Identities = 110/278 (39%), Positives = 151/278 (54%), Gaps = 9/278 (3%)

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
           LG L +SL YD +NN L   I +A  L  +D  G +DPYVK+ LLP   K  K  TK  R
Sbjct: 143 LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DKKKKFETKVHR 200

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTF 246
            TLNP +NE  T+  +   ++  KTL ++V D D+F  ++ IGE +VP+      +T  F
Sbjct: 201 KTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPM------NTVDF 253

Query: 247 NICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYV 306
               E+   +   E +  E+ G I  SL+Y      L V I+   +L  MD  G SDPYV
Sbjct: 254 GHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYV 313

Query: 307 KTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDF 366
           K +L  +  +  K KT +KK TLNP +NE F +E+    + K  + VTV DYD    ND 
Sbjct: 314 KIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDA 373

Query: 367 IGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           IG V +G ++ G  L+HW D L N  + I +WHTL  E
Sbjct: 374 IGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVE 411



 Score =  100 bits (250), Expect = 2e-21
 Identities = 51/112 (45%), Positives = 72/112 (64%), Gaps = 2/112 (1%)

Query: 257 DKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDK 316
           +K E K  E+ G++  SL Y  Q   LLVGI++ A L A+D  G SDPYVK +L P  DK
Sbjct: 133 EKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DK 190

Query: 317 KSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIG 368
           K K +T V +KTLNP FNE+F +++ + +L  K+L + V+D+D    +D IG
Sbjct: 191 KKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 48/165 (29%), Positives = 81/165 (49%), Gaps = 1/165 (0%)

Query: 111 EDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHL 170
           E+  D    E ++   LG + FSL Y      L   I +AK LK MD  GL+DPYVK+HL
Sbjct: 258 EEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHL 317

Query: 171 LPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGE 230
           +    +  K +T   +NTLNP +NE+ + + +  E + +  + ++V D DK   N+ IG+
Sbjct: 318 MQNGKRLKKKKTTIKKNTLNPYYNESFS-FEVPFEQIQKVQVVVTVLDYDKIGKNDAIGK 376

Query: 231 TRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLK 275
             V             ++    + P+ +     +EE    ++++K
Sbjct: 377 VFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVK 421


>gi|5032139 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  184 bits (466), Expect = 2e-46
 Identities = 110/278 (39%), Positives = 151/278 (54%), Gaps = 9/278 (3%)

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
           LG L +SL YD +NN L   I +A  L  +D  G +DPYVK+ LLP   K  K  TK  R
Sbjct: 143 LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DKKKKFETKVHR 200

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTF 246
            TLNP +NE  T+  +   ++  KTL ++V D D+F  ++ IGE +VP+      +T  F
Sbjct: 201 KTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPM------NTVDF 253

Query: 247 NICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYV 306
               E+   +   E +  E+ G I  SL+Y      L V I+   +L  MD  G SDPYV
Sbjct: 254 GHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYV 313

Query: 307 KTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDF 366
           K +L  +  +  K KT +KK TLNP +NE F +E+    + K  + VTV DYD    ND 
Sbjct: 314 KIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDA 373

Query: 367 IGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           IG V +G ++ G  L+HW D L N  + I +WHTL  E
Sbjct: 374 IGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVE 411



 Score =  100 bits (250), Expect = 2e-21
 Identities = 51/112 (45%), Positives = 72/112 (64%), Gaps = 2/112 (1%)

Query: 257 DKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDK 316
           +K E K  E+ G++  SL Y  Q   LLVGI++ A L A+D  G SDPYVK +L P  DK
Sbjct: 133 EKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DK 190

Query: 317 KSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIG 368
           K K +T V +KTLNP FNE+F +++ + +L  K+L + V+D+D    +D IG
Sbjct: 191 KKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 48/165 (29%), Positives = 81/165 (49%), Gaps = 1/165 (0%)

Query: 111 EDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHL 170
           E+  D    E ++   LG + FSL Y      L   I +AK LK MD  GL+DPYVK+HL
Sbjct: 258 EEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHL 317

Query: 171 LPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGE 230
           +    +  K +T   +NTLNP +NE+ + + +  E + +  + ++V D DK   N+ IG+
Sbjct: 318 MQNGKRLKKKKTTIKKNTLNPYYNESFS-FEVPFEQIQKVQVVVTVLDYDKIGKNDAIGK 376

Query: 231 TRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLK 275
             V             ++    + P+ +     +EE    ++++K
Sbjct: 377 VFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVK 421


>gi|209447070 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  184 bits (466), Expect = 2e-46
 Identities = 110/278 (39%), Positives = 151/278 (54%), Gaps = 9/278 (3%)

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
           LG L +SL YD +NN L   I +A  L  +D  G +DPYVK+ LLP   K  K  TK  R
Sbjct: 143 LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DKKKKFETKVHR 200

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTF 246
            TLNP +NE  T+  +   ++  KTL ++V D D+F  ++ IGE +VP+      +T  F
Sbjct: 201 KTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPM------NTVDF 253

Query: 247 NICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYV 306
               E+   +   E +  E+ G I  SL+Y      L V I+   +L  MD  G SDPYV
Sbjct: 254 GHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYV 313

Query: 307 KTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDF 366
           K +L  +  +  K KT +KK TLNP +NE F +E+    + K  + VTV DYD    ND 
Sbjct: 314 KIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDA 373

Query: 367 IGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           IG V +G ++ G  L+HW D L N  + I +WHTL  E
Sbjct: 374 IGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVE 411



 Score =  100 bits (250), Expect = 2e-21
 Identities = 51/112 (45%), Positives = 72/112 (64%), Gaps = 2/112 (1%)

Query: 257 DKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDK 316
           +K E K  E+ G++  SL Y  Q   LLVGI++ A L A+D  G SDPYVK +L P  DK
Sbjct: 133 EKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLP--DK 190

Query: 317 KSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIG 368
           K K +T V +KTLNP FNE+F +++ + +L  K+L + V+D+D    +D IG
Sbjct: 191 KKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 48/165 (29%), Positives = 81/165 (49%), Gaps = 1/165 (0%)

Query: 111 EDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHL 170
           E+  D    E ++   LG + FSL Y      L   I +AK LK MD  GL+DPYVK+HL
Sbjct: 258 EEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHL 317

Query: 171 LPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGE 230
           +    +  K +T   +NTLNP +NE+ + + +  E + +  + ++V D DK   N+ IG+
Sbjct: 318 MQNGKRLKKKKTTIKKNTLNPYYNESFS-FEVPFEQIQKVQVVVTVLDYDKIGKNDAIGK 376

Query: 231 TRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLK 275
             V             ++    + P+ +     +EE    ++++K
Sbjct: 377 VFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVK 421


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score =  176 bits (445), Expect = 5e-44
 Identities = 104/292 (35%), Positives = 153/292 (52%), Gaps = 10/292 (3%)

Query: 110 PEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLH 169
           P  E D + +E      LG + FS+ Y+ + + L   I KA+ L   D +G +DP+VK++
Sbjct: 120 PGSEED-EAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIY 178

Query: 170 LLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIG 229
           LLP   K +KL TK  R  LNP WNET  + G   E ++++ L + V D D+F  N+ IG
Sbjct: 179 LLP--DKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIG 236

Query: 230 ETRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVR 289
           E  +PL K+     +TF     K L   K        RG +L+SL Y+     ++V I++
Sbjct: 237 EVSIPLNKVDLTQMQTF----WKDL---KPCSDGSGSRGELLLSLCYNPSANSIIVNIIK 289

Query: 290 CAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKK 349
             +L AMD  G SDPYVK +L     +  K KT   K+ LNP FNE F ++I    L + 
Sbjct: 290 ARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRET 349

Query: 350 SLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTL 401
           ++ +TV D D    ND IG + L   +    +KHW D +    + + +WH L
Sbjct: 350 TIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQL 401


>gi|92859638 synaptotagmin V [Homo sapiens]
          Length = 386

 Score =  172 bits (435), Expect = 7e-43
 Identities = 107/298 (35%), Positives = 156/298 (52%), Gaps = 9/298 (3%)

Query: 104 RPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLAD 163
           +P  +  E  P   G +  D   LG L +SL YD ++  L   I +A GL  +D  G +D
Sbjct: 86  QPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSD 145

Query: 164 PYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFR 223
           PYV+++LLP   K  +  TK  R TLNP + ET  +  +   ++  + L ++V D D+F 
Sbjct: 146 PYVRVYLLP--DKRRRYETKVHRQTLNPHFGETFAFK-VPYVELGGRVLVMAVYDFDRFS 202

Query: 224 HNEFIGETRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGL 283
            N+ IGE RVP+  +         +   ++L     E++  E+ G I  SL+Y      L
Sbjct: 203 RNDAIGEVRVPMSSVDLGRP----VQAWRELQAAPREEQ--EKLGDICFSLRYVPTAGKL 256

Query: 284 LVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKH 343
            V ++   +L  MD  G SDPYVK +L     K  K KT +KK TLNP +NE F +E+  
Sbjct: 257 TVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPC 316

Query: 344 GDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTL 401
             + K  +E+TV DYD    N+ IG V +G  A G  L+HW D L N  + I +WH+L
Sbjct: 317 DQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSL 374


>gi|216548478 synaptotagmin XI [Homo sapiens]
          Length = 431

 Score =  167 bits (422), Expect = 2e-41
 Identities = 113/338 (33%), Positives = 170/338 (50%), Gaps = 24/338 (7%)

Query: 70  RSPSDGAREDDEDVDQLFGAYGSSPGPS--PGPSPARPPAKPPEDEPDADGYESDDCTAL 127
           R PS G+  D   +   +G    SP  S  PG S    P+ P ED              L
Sbjct: 111 RGPSSGSCIDQLPIKMDYGEELRSPITSLTPGESKTTSPSSPEED------------VML 158

Query: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMDHNGL-ADPYVKLHLLPGASKANKLRTKTLR 186
           G+L FS+ Y+    AL  TI +A GL  MD     +DPY+K+ +LP   K ++++T+ LR
Sbjct: 159 GSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILP--DKRHRVKTRVLR 216

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTF 246
            TL+P ++ET T+YGI    +    L   V   D+F  ++ IGE  VPL  + P+  K  
Sbjct: 217 KTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGK-- 274

Query: 247 NICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYS-DPY 305
              ++    + K   +    RG + +SL Y    Q + V +++  HL  MD  G S +PY
Sbjct: 275 ---VQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPY 331

Query: 306 VKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSND 365
           VK  +     + +K KT VKK TLNP FNE F Y+I    L   S+E  V D+D    N+
Sbjct: 332 VKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNE 391

Query: 366 FIGGVVLGIHA-KGERLKHWFDCLKNKDKRIERWHTLT 402
            +G ++LG H+      +HW +  ++  K + +WH+L+
Sbjct: 392 VVGRLILGAHSVTASGAEHWREVCESPRKPVAKWHSLS 429


>gi|24308219 synaptotagmin IV [Homo sapiens]
          Length = 425

 Score =  165 bits (417), Expect = 8e-41
 Identities = 101/276 (36%), Positives = 147/276 (53%), Gaps = 8/276 (2%)

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGL-ADPYVKLHLLPGASKANKLRTKTL 185
           LGTL FSL Y+ E  A    I +A+GL  MD   + +DPY+K+ +LP   K +K++T+ L
Sbjct: 154 LGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILP--EKKHKVKTRVL 211

Query: 186 RNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKT 245
           R TL+P ++ET T+YGI    +    L  ++   D+F  ++ IGE  +PL  ++ +  K 
Sbjct: 212 RKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIELSEGKM 271

Query: 246 FNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPY 305
                     + K   +    RG +LISL Y S    L V +++  HL   D +G SDPY
Sbjct: 272 L-----MNREIIKRNVRKSSGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPY 326

Query: 306 VKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSND 365
           VK  L     + SK KT VKK T N  FNE F ++I    L   S+E  V D + G  N+
Sbjct: 327 VKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNE 386

Query: 366 FIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTL 401
            IG +VLG  A+G   +HW +      ++I +WH L
Sbjct: 387 VIGQLVLGAAAEGTGGEHWKEICDYPRRQIAKWHVL 422



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 40/116 (34%), Positives = 65/116 (56%), Gaps = 4/116 (3%)

Query: 259 TEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY-SDPYVKTYLRPDVDKK 317
           T ++  E+ G +  SL+Y+ +++  +V I     L AMD     SDPY+K  + P  +KK
Sbjct: 146 TSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILP--EKK 203

Query: 318 SKHKTAVKKKTLNPEFNEEFC-YEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVL 372
            K KT V +KTL+P F+E F  Y I +  + + +L  T+  +D    +D IG V++
Sbjct: 204 HKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLI 259


>gi|39752671 synaptotagmin X [Homo sapiens]
          Length = 523

 Score =  164 bits (416), Expect = 1e-40
 Identities = 110/297 (37%), Positives = 152/297 (51%), Gaps = 9/297 (3%)

Query: 115 DADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGA 174
           D++G +++D    G L+F+L YD EN  L   I KA  L   D  G +DPYVK++LLP  
Sbjct: 220 DSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDR 279

Query: 175 SKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVP 234
            K  K +T+  R TLNP ++ET  +    D+   RK L  SV D D+F  ++ IGE  V 
Sbjct: 280 KK--KFQTRVHRKTLNPLFDETFQFPVAYDQLSNRK-LHFSVYDFDRFSRHDMIGE--VI 334

Query: 235 LKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLA 294
           L  L      +    + K +    TE   L   G I+ SL Y      + + +++C +L 
Sbjct: 335 LDNLFEVSDLSREATVWKDIHCATTESIDL---GEIMFSLCYLPTAGRMTLTVIKCRNLK 391

Query: 295 AMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVT 354
           AMD  G SDPYVK  L  +  +  K KT  KK TLNP +NE   ++I   ++ + SL + 
Sbjct: 392 AMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIA 451

Query: 355 VWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLS 411
           V DYD    N+ IG    G+ A+G    HW + L    K I  WH L  ELPG   S
Sbjct: 452 VMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLL-ELPGRATS 507



 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 49/144 (34%), Positives = 83/144 (57%), Gaps = 8/144 (5%)

Query: 229 GETRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIV 288
           GET   + ++KP   K      +K +  +  +++ ++  G++  +L+Y  + + L+V I+
Sbjct: 200 GETTTSIGRIKPELYK------QKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKII 253

Query: 289 RCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAK 348
           +   L A D  G SDPYVK YL P  D+K K +T V +KTLNP F+E F + + +  L+ 
Sbjct: 254 KALDLPAKDFTGTSDPYVKMYLLP--DRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSN 311

Query: 349 KSLEVTVWDYDIGKSNDFIGGVVL 372
           + L  +V+D+D    +D IG V+L
Sbjct: 312 RKLHFSVYDFDRFSRHDMIGEVIL 335


>gi|45504376 synaptotagmin VI [Homo sapiens]
          Length = 425

 Score =  163 bits (413), Expect = 2e-40
 Identities = 104/287 (36%), Positives = 153/287 (53%), Gaps = 8/287 (2%)

Query: 115 DADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGA 174
           D +  +S+   + G ++FSL YD E   L   I KA  L   D  G +DPYVK++LLP  
Sbjct: 133 DGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLP-- 190

Query: 175 SKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVP 234
            +  KL+T+  R TLNPT++E   ++ +  E++  + L +SV D D+F  ++ IGE  V 
Sbjct: 191 DRKCKLQTRVHRKTLNPTFDENF-HFPVPYEELADRKLHLSVFDFDRFSRHDMIGE--VI 247

Query: 235 LKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLA 294
           L  L      +    + K +    +E   L   G I+ SL Y      L + +++C +L 
Sbjct: 248 LDNLFEASDLSRETSIWKDIQYATSESVDL---GEIMFSLCYLPTAGRLTLTVIKCRNLK 304

Query: 295 AMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVT 354
           AMD  GYSDPYVK  L  D  +  K KT +KK TLNP +NE   ++I   ++ + SL ++
Sbjct: 305 AMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLIS 364

Query: 355 VWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTL 401
           V DYD    N+ IG   +GI A+G    HW + L    K I  WH+L
Sbjct: 365 VMDYDRVGHNEIIGVCRVGITAEGLGRDHWNEMLAYPRKPIAHWHSL 411



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 52/125 (41%), Positives = 76/125 (60%), Gaps = 4/125 (3%)

Query: 250 LEKQLPVDKTEDKSLEER--GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307
           L KQ  VD  + KS   +  G+I  SL+Y  + + L+V I++   L A D  G SDPYVK
Sbjct: 126 LYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVK 185

Query: 308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFI 367
            YL P  D+K K +T V +KTLNP F+E F + + + +LA + L ++V+D+D    +D I
Sbjct: 186 IYLLP--DRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMI 243

Query: 368 GGVVL 372
           G V+L
Sbjct: 244 GEVIL 248


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score =  143 bits (361), Expect = 2e-34
 Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 9/278 (3%)

Query: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRN 187
           G + F+L Y   ++ L   I +A  L   D NG +DPYVK++LLP   K  K +TK  R 
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRK 358

Query: 188 TLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFN 247
           TLNP +NET  +  +   ++ ++ L  SV D D+F  ++ IG+  V L  L     +  +
Sbjct: 359 TLNPVFNETFQF-SVPLAELAQRKLHFSVYDFDRFSRHDLIGQ--VVLDNLLELAEQPPD 415

Query: 248 ICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307
             L + +    +E   L   G +  SL Y      L V I++ ++L AMD  G+SDPYVK
Sbjct: 416 RPLWRDIVEGGSEKADL---GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVK 472

Query: 308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFI 367
             L  +  +  K KT++KK TLNP +NE   +++    +    L + V DYD    N+ I
Sbjct: 473 ASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVI 532

Query: 368 GGVVLGIHAKGER-LKHWFDCLKNKDKRIERWHTLTSE 404
           G   +G  A      +HW + L N  K +E WH L  E
Sbjct: 533 GVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEE 570



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 53/130 (40%), Positives = 67/130 (51%), Gaps = 4/130 (3%)

Query: 104 RPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLAD 163
           +PP +P   +    G E  D   LG L+FSL Y      L  TI KA  LK MD  G +D
Sbjct: 412 QPPDRPLWRDIVEGGSEKAD---LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSD 468

Query: 164 PYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFR 223
           PYVK  L+    +  K +T   +NTLNPT+NE L  + +  E +    L I+V D D   
Sbjct: 469 PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALV-FDVAPESVENVGLSIAVVDYDCIG 527

Query: 224 HNEFIGETRV 233
           HNE IG  RV
Sbjct: 528 HNEVIGVCRV 537


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score =  143 bits (361), Expect = 2e-34
 Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 9/278 (3%)

Query: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRN 187
           G + F+L Y   ++ L   I +A  L   D NG +DPYVK++LLP   K  K +TK  R 
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRK 358

Query: 188 TLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFN 247
           TLNP +NET  +  +   ++ ++ L  SV D D+F  ++ IG+  V L  L     +  +
Sbjct: 359 TLNPVFNETFQF-SVPLAELAQRKLHFSVYDFDRFSRHDLIGQ--VVLDNLLELAEQPPD 415

Query: 248 ICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307
             L + +    +E   L   G +  SL Y      L V I++ ++L AMD  G+SDPYVK
Sbjct: 416 RPLWRDIVEGGSEKADL---GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVK 472

Query: 308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFI 367
             L  +  +  K KT++KK TLNP +NE   +++    +    L + V DYD    N+ I
Sbjct: 473 ASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVI 532

Query: 368 GGVVLGIHAKGER-LKHWFDCLKNKDKRIERWHTLTSE 404
           G   +G  A      +HW + L N  K +E WH L  E
Sbjct: 533 GVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEE 570



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 53/130 (40%), Positives = 67/130 (51%), Gaps = 4/130 (3%)

Query: 104 RPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLAD 163
           +PP +P   +    G E  D   LG L+FSL Y      L  TI KA  LK MD  G +D
Sbjct: 412 QPPDRPLWRDIVEGGSEKAD---LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSD 468

Query: 164 PYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFR 223
           PYVK  L+    +  K +T   +NTLNPT+NE L  + +  E +    L I+V D D   
Sbjct: 469 PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALV-FDVAPESVENVGLSIAVVDYDCIG 527

Query: 224 HNEFIGETRV 233
           HNE IG  RV
Sbjct: 528 HNEVIGVCRV 537


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score =  143 bits (361), Expect = 2e-34
 Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 9/278 (3%)

Query: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRN 187
           G + F+L Y   ++ L   I +A  L   D NG +DPYVK++LLP   K  K +TK  R 
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRK 358

Query: 188 TLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFN 247
           TLNP +NET  +  +   ++ ++ L  SV D D+F  ++ IG+  V L  L     +  +
Sbjct: 359 TLNPVFNETFQF-SVPLAELAQRKLHFSVYDFDRFSRHDLIGQ--VVLDNLLELAEQPPD 415

Query: 248 ICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307
             L + +    +E   L   G +  SL Y      L V I++ ++L AMD  G+SDPYVK
Sbjct: 416 RPLWRDIVEGGSEKADL---GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVK 472

Query: 308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFI 367
             L  +  +  K KT++KK TLNP +NE   +++    +    L + V DYD    N+ I
Sbjct: 473 ASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVI 532

Query: 368 GGVVLGIHAKGER-LKHWFDCLKNKDKRIERWHTLTSE 404
           G   +G  A      +HW + L N  K +E WH L  E
Sbjct: 533 GVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEE 570



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 53/130 (40%), Positives = 67/130 (51%), Gaps = 4/130 (3%)

Query: 104 RPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLAD 163
           +PP +P   +    G E  D   LG L+FSL Y      L  TI KA  LK MD  G +D
Sbjct: 412 QPPDRPLWRDIVEGGSEKAD---LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSD 468

Query: 164 PYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFR 223
           PYVK  L+    +  K +T   +NTLNPT+NE L  + +  E +    L I+V D D   
Sbjct: 469 PYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALV-FDVAPESVENVGLSIAVVDYDCIG 527

Query: 224 HNEFIGETRV 233
           HNE IG  RV
Sbjct: 528 HNEVIGVCRV 537


>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score =  139 bits (349), Expect = 6e-33
 Identities = 102/316 (32%), Positives = 152/316 (48%), Gaps = 22/316 (6%)

Query: 78  EDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYD 137
           E++ED+D L   +      S   S +            ++  +  +    G + FSL Y+
Sbjct: 308 EEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYE 367

Query: 138 QENNALHCTITKAKGLKPMDH-NGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNET 196
           Q+  +L   + +   L   D     ++PYVK +LLP  S+  K +T   R+T+NP ++ET
Sbjct: 368 QQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDET 427

Query: 197 LTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPV 256
           L Y  I +  + ++TL+ SV    +F  N F+GE  + +   K +  K  + CL     +
Sbjct: 428 LRYE-IPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLD--KKLDHCLPLHGKI 484

Query: 257 DKTEDKSL-EERGRILISLKY------------SSQKQG----LLVGIVRCAHLAAMDAN 299
                  L   +G +++SLKY               K G    L V I    +L A  A 
Sbjct: 485 SAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAG 544

Query: 300 GYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDY 358
           G SD +VK YL P  +K SK KT V KKTLNP +N  F Y  ++  DL    LE+TVWD 
Sbjct: 545 GTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDR 604

Query: 359 DIGKSNDFIGGVVLGI 374
           +   SNDF+GGV LG+
Sbjct: 605 EPLASNDFLGGVRLGV 620


>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score =  139 bits (349), Expect = 6e-33
 Identities = 102/316 (32%), Positives = 152/316 (48%), Gaps = 22/316 (6%)

Query: 78  EDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYD 137
           E++ED+D L   +      S   S +            ++  +  +    G + FSL Y+
Sbjct: 308 EEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYE 367

Query: 138 QENNALHCTITKAKGLKPMDH-NGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNET 196
           Q+  +L   + +   L   D     ++PYVK +LLP  S+  K +T   R+T+NP ++ET
Sbjct: 368 QQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDET 427

Query: 197 LTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPV 256
           L Y  I +  + ++TL+ SV    +F  N F+GE  + +   K +  K  + CL     +
Sbjct: 428 LRYE-IPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLD--KKLDHCLPLHGKI 484

Query: 257 DKTEDKSL-EERGRILISLKY------------SSQKQG----LLVGIVRCAHLAAMDAN 299
                  L   +G +++SLKY               K G    L V I    +L A  A 
Sbjct: 485 SAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAG 544

Query: 300 GYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDY 358
           G SD +VK YL P  +K SK KT V KKTLNP +N  F Y  ++  DL    LE+TVWD 
Sbjct: 545 GTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDR 604

Query: 359 DIGKSNDFIGGVVLGI 374
           +   SNDF+GGV LG+
Sbjct: 605 EPLASNDFLGGVRLGV 620


>gi|28376627 synaptotagmin IX [Homo sapiens]
          Length = 491

 Score =  136 bits (343), Expect = 3e-32
 Identities = 93/290 (32%), Positives = 140/290 (48%), Gaps = 8/290 (2%)

Query: 115 DADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGA 174
           D D     +  A G L+F L YD +   L   I KA  L   D +G +DPYVK++LLP  
Sbjct: 209 DNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLP-- 266

Query: 175 SKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVP 234
            +  K +TK  R TLNP ++E   +  +   D+  + L  SV D D+F  ++ IG+  V 
Sbjct: 267 DRKTKHQTKVHRKTLNPVFDEVFLF-PVPYNDLEARKLHFSVYDFDRFSRHDLIGQVVVD 325

Query: 235 LKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLA 294
                 +  +     L K +     ++  L   G ++ SL Y      L + I++  +L 
Sbjct: 326 HFLDLADFPR--ECILWKDIEYVTNDNVDL---GELMFSLCYLPTAGRLTITIIKARNLK 380

Query: 295 AMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVT 354
           AMD  G SDPYVK  L  D  +  K KT+ K+ TLNP +NE   +++   ++ +  L + 
Sbjct: 381 AMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIA 440

Query: 355 VWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
           V DYD    N+ IG   +G  A+     HW + L    K I  WH+L  +
Sbjct: 441 VMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLVEK 490



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 49/125 (39%), Positives = 74/125 (59%), Gaps = 4/125 (3%)

Query: 250 LEKQLPVDKTEDKSLEER--GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307
           L KQ  +D  + +    +  G++   LKY    + L+V I +  +L A D +G SDPYVK
Sbjct: 202 LYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVK 261

Query: 308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFI 367
            YL P  D+K+KH+T V +KTLNP F+E F + + + DL  + L  +V+D+D    +D I
Sbjct: 262 IYLLP--DRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLI 319

Query: 368 GGVVL 372
           G VV+
Sbjct: 320 GQVVV 324


>gi|40068038 B/K protein [Homo sapiens]
          Length = 474

 Score =  125 bits (313), Expect = 9e-29
 Identities = 92/288 (31%), Positives = 143/288 (49%), Gaps = 24/288 (8%)

Query: 127 LGTLDFSLLYDQENNALHCTITKAKGLKP-MDHNGL------ADPYVKLHLLPGASKANK 179
           LG L FS  YD  +N L   + +A+ L P + H+G       ++PYVK+ LLP   + N 
Sbjct: 185 LGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLP--DQKNS 242

Query: 180 LRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKL- 238
            +T   R T  P + E  T+  I   +  R+TL ++V D DKF  +  IG+  VPL ++ 
Sbjct: 243 KQTGVKRKTQKPVFEERYTFE-IPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSVPLCEVD 301

Query: 239 --KPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAM 296
             K  H        +  +P  + E     E G +L+SL Y      L V ++R   L   
Sbjct: 302 LVKGGHW------WKALIPSSQNE----VELGELLLSLNYLPSAGRLNVDVIRAKQLLQT 351

Query: 297 DANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVW 356
           D +  SDP+VK  L   +      KT+  + T++P +NE F +++   +L   SL  TV+
Sbjct: 352 DVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEELENASLVFTVF 411

Query: 357 DYDIGKSNDFIGGVVLGIHAKG-ERLKHWFDCLKNKDKRIERWHTLTS 403
            +++  SNDFIG +V+G ++ G     HW   L      +E+WH+L S
Sbjct: 412 GHNMKSSNDFIGRIVIGQYSSGPSETNHWRRMLNTHRTAVEQWHSLRS 459


>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score =  117 bits (294), Expect = 1e-26
 Identities = 81/241 (33%), Positives = 120/241 (49%), Gaps = 36/241 (14%)

Query: 163 DPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKF 222
           D YVK +LLP  S+ NK +TK +R   NP +NETL Y  I+   +  +TL++SV   D+F
Sbjct: 444 DAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501

Query: 223 RHNEFIGETRVPLKKLK-PNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQ 281
             N F+GE  +P       N T  + +   K   V+   D  L+ +G + + L+Y   ++
Sbjct: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPK---VEFAPDIGLQYKGELTVVLRYIPPEE 558

Query: 282 GLL-----------------------------VGIVRCAHLAAMDANGYSDPYVKTYLRP 312
            L+                             V I    +L A+ + G SD +VK YL P
Sbjct: 559 NLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618

Query: 313 DVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDYDIGKSNDFIGGVV 371
           D  K +KHKT V KK++NP++N  F +  I   D+    LE+T+WD +   SN F+GGV 
Sbjct: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678

Query: 372 L 372
           L
Sbjct: 679 L 679



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 2/104 (1%)

Query: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY-SDPYVKTYLRPDVDKKSKHKTAVKK 326
           G IL+ + Y  +  GL + +  C +LA  D     +D YVK+YL PD  + +K KT ++ 
Sbjct: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467

Query: 327 KTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGV 370
            T NPEFNE   Y I H  L  ++L+++VW YD    N F+G V
Sbjct: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEV 510



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 32/91 (35%), Positives = 52/91 (57%)

Query: 143 LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGI 202
           L   I +AK L  +   G +D +VK +LLP  SKA K +T  ++ ++NP WN T  + GI
Sbjct: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648

Query: 203 TDEDMIRKTLRISVCDEDKFRHNEFIGETRV 233
             +D+    L +++ D++ F  N F+G  R+
Sbjct: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679


>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
          Length = 752

 Score =  117 bits (294), Expect = 1e-26
 Identities = 81/241 (33%), Positives = 120/241 (49%), Gaps = 36/241 (14%)

Query: 163 DPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKF 222
           D YVK +LLP  S+ NK +TK +R   NP +NETL Y  I+   +  +TL++SV   D+F
Sbjct: 466 DAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 523

Query: 223 RHNEFIGETRVPLKKLK-PNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQ 281
             N F+GE  +P       N T  + +   K   V+   D  L+ +G + + L+Y   ++
Sbjct: 524 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPK---VEFAPDIGLQYKGELTVVLRYIPPEE 580

Query: 282 GLL-----------------------------VGIVRCAHLAAMDANGYSDPYVKTYLRP 312
            L+                             V I    +L A+ + G SD +VK YL P
Sbjct: 581 NLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 640

Query: 313 DVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDYDIGKSNDFIGGVV 371
           D  K +KHKT V KK++NP++N  F +  I   D+    LE+T+WD +   SN F+GGV 
Sbjct: 641 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 700

Query: 372 L 372
           L
Sbjct: 701 L 701



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 2/104 (1%)

Query: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY-SDPYVKTYLRPDVDKKSKHKTAVKK 326
           G IL+ + Y  +  GL + +  C +LA  D     +D YVK+YL PD  + +K KT ++ 
Sbjct: 430 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 489

Query: 327 KTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGV 370
            T NPEFNE   Y I H  L  ++L+++VW YD    N F+G V
Sbjct: 490 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEV 532



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 32/91 (35%), Positives = 52/91 (57%)

Query: 143 LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGI 202
           L   I +AK L  +   G +D +VK +LLP  SKA K +T  ++ ++NP WN T  + GI
Sbjct: 611 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 670

Query: 203 TDEDMIRKTLRISVCDEDKFRHNEFIGETRV 233
             +D+    L +++ D++ F  N F+G  R+
Sbjct: 671 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 701


>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score =  117 bits (294), Expect = 1e-26
 Identities = 81/241 (33%), Positives = 120/241 (49%), Gaps = 36/241 (14%)

Query: 163 DPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKF 222
           D YVK +LLP  S+ NK +TK +R   NP +NETL Y  I+   +  +TL++SV   D+F
Sbjct: 444 DAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501

Query: 223 RHNEFIGETRVPLKKLK-PNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQ 281
             N F+GE  +P       N T  + +   K   V+   D  L+ +G + + L+Y   ++
Sbjct: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPK---VEFAPDIGLQYKGELTVVLRYIPPEE 558

Query: 282 GLL-----------------------------VGIVRCAHLAAMDANGYSDPYVKTYLRP 312
            L+                             V I    +L A+ + G SD +VK YL P
Sbjct: 559 NLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618

Query: 313 DVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDYDIGKSNDFIGGVV 371
           D  K +KHKT V KK++NP++N  F +  I   D+    LE+T+WD +   SN F+GGV 
Sbjct: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678

Query: 372 L 372
           L
Sbjct: 679 L 679



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 2/104 (1%)

Query: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY-SDPYVKTYLRPDVDKKSKHKTAVKK 326
           G IL+ + Y  +  GL + +  C +LA  D     +D YVK+YL PD  + +K KT ++ 
Sbjct: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467

Query: 327 KTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGV 370
            T NPEFNE   Y I H  L  ++L+++VW YD    N F+G V
Sbjct: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEV 510



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 32/91 (35%), Positives = 52/91 (57%)

Query: 143 LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGI 202
           L   I +AK L  +   G +D +VK +LLP  SKA K +T  ++ ++NP WN T  + GI
Sbjct: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648

Query: 203 TDEDMIRKTLRISVCDEDKFRHNEFIGETRV 233
             +D+    L +++ D++ F  N F+G  R+
Sbjct: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679


>gi|94536846 synaptotagmin VIII [Homo sapiens]
          Length = 401

 Score =  115 bits (289), Expect = 6e-26
 Identities = 86/291 (29%), Positives = 134/291 (46%), Gaps = 18/291 (6%)

Query: 113 EPDADGYESD--DCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHL 170
           +PD DG ES   D    G L  SL +D  +  +   + +A  L+P    G  DPY ++ +
Sbjct: 102 QPDVDGLESSPGDAQQWGRLQLSLEFDFGSQEIRVGLRQAADLRP---GGTVDPYARVSV 158

Query: 171 LPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGE 230
              A   ++  TK  R TL P ++ET  ++ I   ++   TL++ + +  +F  +E +GE
Sbjct: 159 STQAGHRHE--TKVHRGTLCPVFDETCCFH-IPQAELPGATLQVQLFNFKRFSGHEPLGE 215

Query: 231 TRVPLKKLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRC 290
            R+PL  +   H       LE    +        E+ G +  SL+Y      L V ++  
Sbjct: 216 LRLPLGTVDLQHV------LEHWYLLGPPAATQPEQVGELCFSLRYVPSSGRLTVVVLEA 269

Query: 291 AHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKS 350
             L      G ++PYVK  L  +  K  K KTA KK T  P FNE F + +    +    
Sbjct: 270 RGLRP----GLAEPYVKVQLMLNQRKWKKRKTATKKGTAAPYFNEAFTFLVPFSQVQNVD 325

Query: 351 LEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTL 401
           L + VWD  +    + +G V LG  A G+ L+HW D L +  + I + H L
Sbjct: 326 LVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHWADMLAHARRPIAQRHPL 376


>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
          Length = 376

 Score =  107 bits (266), Expect = 3e-23
 Identities = 79/291 (27%), Positives = 133/291 (45%), Gaps = 23/291 (7%)

Query: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMD-HNGLADPYVKLHLLPGASKANKLRTKTLR 186
           G + F++ Y +    LH  + + K L   D     +DPYVK +LLP   K  K +T  ++
Sbjct: 72  GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 131

Query: 187 NTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKL----KPNH 242
            TLNP +NE L  Y I  + +  + L +S+   D F+ N F+GE  + L+      K N 
Sbjct: 132 KTLNPVYNEILR-YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNK 190

Query: 243 TKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQ---------KQGLLVGIVRCAHL 293
              +     K  PV        E RG + ++L+Y  +            + + +  C  L
Sbjct: 191 QLRWYPLKRKTAPV----ALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDL 246

Query: 294 AAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLE 352
             +    + + +VK  + PD  +KS+ KT    KT NP FN    Y+  +  DL +  +E
Sbjct: 247 PLL-RGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVE 305

Query: 353 VTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTS 403
           +TVWD+    +N F+GG+ +G    G+      D + +  + +  W  + +
Sbjct: 306 LTVWDH-YKLTNQFLGGLRIGF-GTGKSYGTEVDWMDSTSEEVALWEKMVN 354



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 54/140 (38%), Positives = 73/140 (52%), Gaps = 10/140 (7%)

Query: 263 SLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY-SDPYVKTYLRPDVDKKSKHK 321
           +LE +G I  +++Y    + L V + +C  LAA D     SDPYVK YL PD  K  K K
Sbjct: 67  NLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKK 126

Query: 322 TAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERL 381
           T V KKTLNP +NE   Y+I+   L  + L +++W  D  K N F+G V L        L
Sbjct: 127 TLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELD-------L 179

Query: 382 KHWFDCLKNKDKRIERWHTL 401
           + W     NK  +  RW+ L
Sbjct: 180 ETW--DWDNKQNKQLRWYPL 197


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.136    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,043,895
Number of Sequences: 37866
Number of extensions: 1082786
Number of successful extensions: 11802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 632
Number of HSP's that attempted gapping in prelim test: 8088
Number of HSP's gapped (non-prelim): 3267
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.