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Search of human proteins with 58331242
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58331242 formin homology 2 domain containing 3 [Homo
sapiens]
(1439 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 2858 0.0
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 624 e-178
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 155 3e-37
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 155 3e-37
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 144 6e-34
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 144 6e-34
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 144 6e-34
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 144 6e-34
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 140 9e-33
gi|33356148 formin-like 1 [Homo sapiens] 127 8e-29
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 127 1e-28
gi|160707881 formin 2 [Homo sapiens] 123 1e-27
gi|157168329 formin 1 [Homo sapiens] 120 7e-27
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 116 1e-25
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 116 1e-25
gi|52485606 formin-like 2 [Homo sapiens] 115 4e-25
gi|145309324 FH2 domain containing 1 [Homo sapiens] 107 6e-23
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 99 4e-20
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 99 4e-20
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 91 6e-18
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 61 7e-09
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 3e-08
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 59 4e-08
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 4e-08
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 4e-08
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 4e-08
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 57 1e-07
gi|56549694 enabled homolog isoform a [Homo sapiens] 57 2e-07
gi|39930375 enabled homolog isoform b [Homo sapiens] 57 2e-07
gi|55741677 SET domain containing 1A [Homo sapiens] 57 2e-07
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 2858 bits (7410), Expect = 0.0
Identities = 1439/1439 (100%), Positives = 1439/1439 (100%)
Query: 1 MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCT 60
MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCT
Sbjct: 1 MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCT 60
Query: 61 LQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSG 120
LQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSG
Sbjct: 61 LQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSG 120
Query: 121 RDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD 180
RDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD
Sbjct: 121 RDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD 180
Query: 181 GMNGVINRNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRG 240
GMNGVINRNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRG
Sbjct: 181 GMNGVINRNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRG 240
Query: 241 VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQR 300
VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQR
Sbjct: 241 VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQR 300
Query: 301 HLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSGGGEHRGLDRR 360
HLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSGGGEHRGLDRR
Sbjct: 301 HLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSGGGEHRGLDRR 360
Query: 361 RSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSSRPSSGSSVP 420
RSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSSRPSSGSSVP
Sbjct: 361 RSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSSRPSSGSSVP 420
Query: 421 TTPTSSVSPPQEARLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNK 480
TTPTSSVSPPQEARLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNK
Sbjct: 421 TTPTSSVSPPQEARLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNK 480
Query: 481 FSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACL 540
FSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACL
Sbjct: 481 FSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACL 540
Query: 541 APLSHSPSSSDSQEALTVSASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQD 600
APLSHSPSSSDSQEALTVSASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQD
Sbjct: 541 APLSHSPSSSDSQEALTVSASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQD 600
Query: 601 IASAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREEKE 660
IASAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREEKE
Sbjct: 601 IASAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREEKE 660
Query: 661 DKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRT 720
DKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRT
Sbjct: 661 DKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRT 720
Query: 721 QQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSIS 780
QQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSIS
Sbjct: 721 QQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSIS 780
Query: 781 PDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGH 840
PDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGH
Sbjct: 781 PDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGH 840
Query: 841 REAPGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRG 900
REAPGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRG
Sbjct: 841 REAPGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRG 900
Query: 901 QPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKSKEL 960
QPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKSKEL
Sbjct: 901 QPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKSKEL 960
Query: 961 SVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIEKIL 1020
SVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIEKIL
Sbjct: 961 SVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIEKIL 1020
Query: 1021 TMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEV 1080
TMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEV
Sbjct: 1021 TMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEV 1080
Query: 1081 AEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTVHKQ 1140
AEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTVHKQ
Sbjct: 1081 AEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTVHKQ 1140
Query: 1141 SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIA 1200
SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIA
Sbjct: 1141 SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIA 1200
Query: 1201 KHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFC 1260
KHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFC
Sbjct: 1201 KHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFC 1260
Query: 1261 RIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDSGKFSGSSPAPPSQPQGLSY 1320
RIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDSGKFSGSSPAPPSQPQGLSY
Sbjct: 1261 RIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDSGKFSGSSPAPPSQPQGLSY 1320
Query: 1321 AEDAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSSWTMGTDDSPNVTDDAAD 1380
AEDAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSSWTMGTDDSPNVTDDAAD
Sbjct: 1321 AEDAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSSWTMGTDDSPNVTDDAAD 1380
Query: 1381 EIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARALGLVGTSELQL 1439
EIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARALGLVGTSELQL
Sbjct: 1381 EIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARALGLVGTSELQL 1439
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 624 bits (1610), Expect = e-178
Identities = 351/672 (52%), Positives = 458/672 (68%), Gaps = 53/672 (7%)
Query: 785 PNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHREAP 844
P K P P PK E IW+ PR L I D+DF+DLGE++D D+L+V+
Sbjct: 513 PEPKEP-LIPASPKAEP--IWELPTRAPR-LSIGDLDFSDLGEDEDQDMLNVESVEAGKD 568
Query: 845 GPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQP- 902
P P PP P G+PPPPP P PPPP+ G PPP AP +P P
Sbjct: 569 IPAPSPPLPLLSGVPPPPPLP-----PPPPIKGPFPPPPPLPLAAP-------LPHSVPD 616
Query: 903 --TFTKKKKTIRLFWNEVRPFDWPCKNNRR---CREFLWSKLEPIKVDTSRLEHLFESKS 957
K+KT++LFW E++ + R C LW+ L+P+ VDT+RLEHLFES++
Sbjct: 617 SSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCAT-LWASLDPVSVDTARLEHLFESRA 675
Query: 958 KELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIE 1017
KE+ SKK A +G+R VLD KRSNAINIGLT LPP IK A+LNFDE+A++K+GIE
Sbjct: 676 KEVLPSKK-AGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIE 734
Query: 1018 KILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTE 1077
K+LTM+PT+EE+QKI+EAQLANP+IPLG AE FL+TL+SI L+ARL LWAFK+DY++ E
Sbjct: 735 KLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSME 794
Query: 1078 KEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTV 1137
+E+AEPL DLK G++QL N T IL+TLLA+GNFLNG+ + FELSYLEKV EVKDTV
Sbjct: 795 REIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTV 854
Query: 1138 HKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLK 1197
+QSLLHH+C++V++ P+SSDLYSEI A+TR AKVDF+QL +NL Q+ERR +A+ + L+
Sbjct: 855 RRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLR 914
Query: 1198 AIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNIN 1257
++AKHE+ P L+ R++ FL CA R+ +L+IVHRR+ NRFH+FLL++G+ P A REV I
Sbjct: 915 SLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIM 974
Query: 1258 KFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDSGKFS---GSSPAPPSQ 1314
+FC + EFALEYRT RERVLQQ+QK+A +RERNKTRG+MIT++ KFS G +P+ PS
Sbjct: 975 QFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSV 1034
Query: 1315 PQGLSYAE---DAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSS-------- 1363
P +S DA H +MK++L TS P ED T +R SRG S
Sbjct: 1035 PVAVSSGPGRGDADSHASMKSLL-TSRP--EDT-------THNRRSRGMVQSSSPIMPTV 1084
Query: 1364 --WTMGTDDSP--NVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKS 1419
T ++ P ++ D +DEIMD +V+S T+ + + RERKRSR NRKSLRRTLKS
Sbjct: 1085 GPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKS 1144
Query: 1420 GLTPEEARALGL 1431
GL + +ALGL
Sbjct: 1145 GLGDDLVQALGL 1156
Score = 432 bits (1110), Expect = e-120
Identities = 238/440 (54%), Positives = 297/440 (67%), Gaps = 17/440 (3%)
Query: 1 MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCT 60
++ + RVQ+L+DTDPF NFPEP R P + L LG Q+ VHRLL AP KL+DC
Sbjct: 13 VSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCA 72
Query: 61 LQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSG 120
LQ+S +G YLD E +L EQR+ LEGF ++ +G+K ++ILRTQLSVRV+A +EKLY+SSG
Sbjct: 73 LQVSPSGYYLDTELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYSSSG 132
Query: 121 RDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD 180
+LRR+LFSLKQIFQ+DKDLV EFV +EGL+CLI+VGA AD NYQ+YILRALGQ+ML+VD
Sbjct: 133 PELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVD 192
Query: 181 GMNGVINRNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRG 240
GM GV+ ++TIQWLYTL S RLVVKTALKLLLVFVEYSE+NAPL I+AV +V + G
Sbjct: 193 GMLGVVAHSDTIQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTG 252
Query: 241 VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQR 300
PW+N++ ILEEK+G D ELLVY +TL+NKTL+ LPDQD+FYDV D LE+ G+ A+ QR
Sbjct: 253 APPWANLVSILEEKNGADPELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQR 312
Query: 301 HLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSGGGEHRGLDRR 360
HL GTD+DL QL +YE AL+ EDGD P G R+RR+ S G R
Sbjct: 313 HLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRRERRKPS-------SEEGKRSR 365
Query: 361 RSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSSRPSSG--SS 418
RS ++ PT P S P+ S G P SG +S
Sbjct: 366 RSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVG--------PPSGLQAS 417
Query: 419 VPTTPTSSVSPPQEARLERS 438
V PT SV+P + ERS
Sbjct: 418 VNLFPTISVAPSADTSSERS 437
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 155 bits (391), Expect = 3e-37
Identities = 119/472 (25%), Positives = 220/472 (46%), Gaps = 46/472 (9%)
Query: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLL-----VPPPPVFNAPQGLGWSQVP-- 898
PPPPP P+ G+PPPPPPP PPPP+PG + VPPPP G +P
Sbjct: 313 PPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPIL 367
Query: 899 ----RGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDT----SRLE 950
+ + F + RL W ++RP + C W K+ K + +LE
Sbjct: 368 PFGLKPKKEFKPEISMRRLNWLKIRPHEM----TENC---FWIKVNENKYENVDLLCKLE 420
Query: 951 HLF----ESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPP-RTIKIAILN 1005
+ F + + +E + +K + K +E+ LDSK + ++I L+ P I++ IL
Sbjct: 421 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
Query: 1006 FDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLH 1065
DE L + I+ ++ +P E+ + +Q + L EQF++ +S++ L RL
Sbjct: 481 VDETRLAESMIQNLIKHLPDQEQLNSL--SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLS 538
Query: 1066 LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---- 1121
FK+ +E + ++ + ++++ +K+ +L +L +GN++N + A
Sbjct: 539 AILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFG 598
Query: 1122 FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDN 1181
F LS L K+ + K K +LLH + + E +PD + ++ + +++KV + L+ N
Sbjct: 599 FNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKN 658
Query: 1182 LCQMERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF 1240
L QM R+ + L+ E + +MS F+ E+ L +H + + S
Sbjct: 659 LRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSI 718
Query: 1241 LLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNK 1292
+ G+ +++V++ F ++ F RTT + +++ K+ E+ K
Sbjct: 719 I---GYYAIDVKKVSVEDFLTDLNNF----RTTFMQAIKENIKKREAEEKEK 763
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 155 bits (391), Expect = 3e-37
Identities = 119/472 (25%), Positives = 220/472 (46%), Gaps = 46/472 (9%)
Query: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLL-----VPPPPVFNAPQGLGWSQVP-- 898
PPPPP P+ G+PPPPPPP PPPP+PG + VPPPP G +P
Sbjct: 576 PPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPIL 630
Query: 899 ----RGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDT----SRLE 950
+ + F + RL W ++RP + C W K+ K + +LE
Sbjct: 631 PFGLKPKKEFKPEISMRRLNWLKIRPHEM----TENC---FWIKVNENKYENVDLLCKLE 683
Query: 951 HLF----ESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPP-RTIKIAILN 1005
+ F + + +E + +K + K +E+ LDSK + ++I L+ P I++ IL
Sbjct: 684 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 743
Query: 1006 FDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLH 1065
DE L + I+ ++ +P E+ + +Q + L EQF++ +S++ L RL
Sbjct: 744 VDETRLAESMIQNLIKHLPDQEQLNSL--SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLS 801
Query: 1066 LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---- 1121
FK+ +E + ++ + ++++ +K+ +L +L +GN++N + A
Sbjct: 802 AILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFG 861
Query: 1122 FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDN 1181
F LS L K+ + K K +LLH + + E +PD + ++ + +++KV + L+ N
Sbjct: 862 FNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKN 921
Query: 1182 LCQMERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF 1240
L QM R+ + L+ E + +MS F+ E+ L +H + + S
Sbjct: 922 LRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSI 981
Query: 1241 LLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNK 1292
+ G+ +++V++ F ++ F RTT + +++ K+ E+ K
Sbjct: 982 I---GYYAIDVKKVSVEDFLTDLNNF----RTTFMQAIKENIKKREAEEKEK 1026
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 144 bits (363), Expect = 6e-34
Identities = 123/474 (25%), Positives = 219/474 (46%), Gaps = 52/474 (10%)
Query: 842 EAPGPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFN------------- 887
EA PPPPPP P G+PPPPP P IPPPP PG + +PPPP F
Sbjct: 701 EAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP-PG-MGMPPPPPFGFGVPAAPVLPFGL 758
Query: 888 APQGLGWSQVPRGQPTFTK---KKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLE---P 941
P+ L +V +P ++K + + FW +V K +R L++KL
Sbjct: 759 TPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKV-------KEDRFENNELFAKLTLTFS 811
Query: 942 IKVDTSRLEHLFESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGL-TVLPPPRTIK 1000
+ TS+ + E ++ SV KK K +E+ VLDSK + ++I L + P + IK
Sbjct: 812 AQTKTSKAKKDQEGGEEKKSVQKK-----KVKELKVLDSKTAQNLSIFLGSFRMPYQEIK 866
Query: 1001 IAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISEL 1060
IL +E L + I+ ++ +P E+ + + E L + L +EQF + + ++ L
Sbjct: 867 NVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE--LKDEYDDLAESEQFGVVMGTVPRL 924
Query: 1061 SARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAK 1120
RL+ FK+ + + + ++ + ++L +++ +L L +GN++N +
Sbjct: 925 RPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRN 984
Query: 1121 A----FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFD 1176
A F +S+L K+ + K T K +LLH + + ++PD E+ + ++++V +
Sbjct: 985 AGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAE 1044
Query: 1177 QLQDNLCQMERRCK-ASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIIN 1235
LQ NL QM+++ D A + K ++M+ F+KD E+ L+++H +
Sbjct: 1045 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1104
Query: 1236 RFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRE 1289
+ + P + + EF ++ R LQ ++ RE
Sbjct: 1105 LYKELGEYFLFDPKKLS----------VEEFFMDLHNFRNMFLQAVKENQKRRE 1148
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/69 (42%), Positives = 35/69 (50%), Gaps = 25/69 (36%)
Query: 843 APGP---PPPPPPTFLGLPPPPPPPLLDSI---------------PPPPVPGNLLVPPPP 884
APG PPPPPP PPPPPPPL + PPPP+ G+ +PPPP
Sbjct: 592 APGDSTTPPPPPP-----PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPP 646
Query: 885 VFNAPQGLG 893
P+G+G
Sbjct: 647 PL--PEGVG 653
Score = 45.1 bits (105), Expect = 5e-04
Identities = 27/66 (40%), Positives = 32/66 (48%), Gaps = 12/66 (18%)
Query: 843 APGPPPPPPPTFLG--LPPP--------PPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGL 892
AP PP PP P G +PPP PPPP PPPP+PG + + PP + P G
Sbjct: 571 APVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPP--SLPGGT 628
Query: 893 GWSQVP 898
S P
Sbjct: 629 AISPPP 634
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/40 (52%), Positives = 24/40 (60%), Gaps = 4/40 (10%)
Query: 848 PPPPPTFLGLPPPPPPPLLDS---IPPPPVPGNLLVPPPP 884
PP P+ +PP PP P DS IPPPP PG+ PPPP
Sbjct: 564 PPSVPSRAPVPPAPPLPG-DSGTIIPPPPAPGDSTTPPPP 602
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 144 bits (363), Expect = 6e-34
Identities = 123/474 (25%), Positives = 219/474 (46%), Gaps = 52/474 (10%)
Query: 842 EAPGPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFN------------- 887
EA PPPPPP P G+PPPPP P IPPPP PG + +PPPP F
Sbjct: 710 EAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP-PG-MGMPPPPPFGFGVPAAPVLPFGL 767
Query: 888 APQGLGWSQVPRGQPTFTK---KKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLE---P 941
P+ L +V +P ++K + + FW +V K +R L++KL
Sbjct: 768 TPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKV-------KEDRFENNELFAKLTLTFS 820
Query: 942 IKVDTSRLEHLFESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGL-TVLPPPRTIK 1000
+ TS+ + E ++ SV KK K +E+ VLDSK + ++I L + P + IK
Sbjct: 821 AQTKTSKAKKDQEGGEEKKSVQKK-----KVKELKVLDSKTAQNLSIFLGSFRMPYQEIK 875
Query: 1001 IAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISEL 1060
IL +E L + I+ ++ +P E+ + + E L + L +EQF + + ++ L
Sbjct: 876 NVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE--LKDEYDDLAESEQFGVVMGTVPRL 933
Query: 1061 SARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAK 1120
RL+ FK+ + + + ++ + ++L +++ +L L +GN++N +
Sbjct: 934 RPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRN 993
Query: 1121 A----FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFD 1176
A F +S+L K+ + K T K +LLH + + ++PD E+ + ++++V +
Sbjct: 994 AGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAE 1053
Query: 1177 QLQDNLCQMERRCK-ASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIIN 1235
LQ NL QM+++ D A + K ++M+ F+KD E+ L+++H +
Sbjct: 1054 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1113
Query: 1236 RFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRE 1289
+ + P + + EF ++ R LQ ++ RE
Sbjct: 1114 LYKELGEYFLFDPKKLS----------VEEFFMDLHNFRNMFLQAVKENQKRRE 1157
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/69 (42%), Positives = 35/69 (50%), Gaps = 25/69 (36%)
Query: 843 APGP---PPPPPPTFLGLPPPPPPPLLDSI---------------PPPPVPGNLLVPPPP 884
APG PPPPPP PPPPPPPL + PPPP+ G+ +PPPP
Sbjct: 601 APGDSTTPPPPPP-----PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPP 655
Query: 885 VFNAPQGLG 893
P+G+G
Sbjct: 656 PL--PEGVG 662
Score = 45.1 bits (105), Expect = 5e-04
Identities = 27/66 (40%), Positives = 32/66 (48%), Gaps = 12/66 (18%)
Query: 843 APGPPPPPPPTFLG--LPPP--------PPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGL 892
AP PP PP P G +PPP PPPP PPPP+PG + + PP + P G
Sbjct: 580 APVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPP--SLPGGT 637
Query: 893 GWSQVP 898
S P
Sbjct: 638 AISPPP 643
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/40 (52%), Positives = 24/40 (60%), Gaps = 4/40 (10%)
Query: 848 PPPPPTFLGLPPPPPPPLLDS---IPPPPVPGNLLVPPPP 884
PP P+ +PP PP P DS IPPPP PG+ PPPP
Sbjct: 573 PPSVPSRAPVPPAPPLPG-DSGTIIPPPPAPGDSTTPPPP 611
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 144 bits (363), Expect = 6e-34
Identities = 123/477 (25%), Positives = 219/477 (45%), Gaps = 39/477 (8%)
Query: 843 APGPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVP-GNLLVPPPPVFNAPQGLGWSQVPRG 900
AP PPPPPP P +G+PPPPPPPLL PPPP P G VPPPP + G Q
Sbjct: 575 APLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG--VPPPPGISLNLPYGMKQKKMY 632
Query: 901 QPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRL---------EH 951
+P + K R+ W+++ P + + C W +++ K + L
Sbjct: 633 KPEVSMK----RINWSKIEPTEL----SENC---FWLRVKEDKFENPDLFAKLALNFATQ 681
Query: 952 LFESKSKELSVSKKTAADGKR-QEIIVLDSKRSNAINIGL-TVLPPPRTIKIAILNFDEY 1009
+ K+ E KKT K+ +E+ +LD K + ++I L + P I+ IL +E
Sbjct: 682 IKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNED 741
Query: 1010 ALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAF 1069
L++ I+ ++ +P E+K + A+L N L EQF + +SS+ L RL F
Sbjct: 742 MLSEALIQNLVKHLP--EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF 799
Query: 1070 KMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA----FELS 1125
K+ +E + ++ + ++L+ +++ +L +L +GN++N + A F+++
Sbjct: 800 KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKIN 859
Query: 1126 YLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQM 1185
+L K+ + K K +LLH + + E + D E+ + ++KV L+ NL M
Sbjct: 860 FLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASM 919
Query: 1186 ERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF--LL 1242
E++ +K + E ++M+ F K E+ L +H ++ + +
Sbjct: 920 EQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYF 979
Query: 1243 FMGHPPYAIREV--NINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKM 1297
+I E ++N F + E E RE +++K +RA + + K+
Sbjct: 980 IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRRE--MEEKTRRAKLAKEKAEQEKL 1034
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 144 bits (363), Expect = 6e-34
Identities = 123/477 (25%), Positives = 219/477 (45%), Gaps = 39/477 (8%)
Query: 843 APGPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVP-GNLLVPPPPVFNAPQGLGWSQVPRG 900
AP PPPPPP P +G+PPPPPPPLL PPPP P G VPPPP + G Q
Sbjct: 575 APLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG--VPPPPGISLNLPYGMKQKKMY 632
Query: 901 QPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRL---------EH 951
+P + K R+ W+++ P + + C W +++ K + L
Sbjct: 633 KPEVSMK----RINWSKIEPTEL----SENC---FWLRVKEDKFENPDLFAKLALNFATQ 681
Query: 952 LFESKSKELSVSKKTAADGKR-QEIIVLDSKRSNAINIGL-TVLPPPRTIKIAILNFDEY 1009
+ K+ E KKT K+ +E+ +LD K + ++I L + P I+ IL +E
Sbjct: 682 IKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNED 741
Query: 1010 ALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAF 1069
L++ I+ ++ +P E+K + A+L N L EQF + +SS+ L RL F
Sbjct: 742 MLSEALIQNLVKHLP--EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF 799
Query: 1070 KMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA----FELS 1125
K+ +E + ++ + ++L+ +++ +L +L +GN++N + A F+++
Sbjct: 800 KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKIN 859
Query: 1126 YLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQM 1185
+L K+ + K K +LLH + + E + D E+ + ++KV L+ NL M
Sbjct: 860 FLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASM 919
Query: 1186 ERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF--LL 1242
E++ +K + E ++M+ F K E+ L +H ++ + +
Sbjct: 920 EQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYF 979
Query: 1243 FMGHPPYAIREV--NINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKM 1297
+I E ++N F + E E RE +++K +RA + + K+
Sbjct: 980 IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRRE--MEEKTRRAKLAKEKAEQEKL 1034
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 140 bits (353), Expect = 9e-33
Identities = 115/372 (30%), Positives = 179/372 (48%), Gaps = 42/372 (11%)
Query: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPT-F 904
PPPPPPP G+ PPPPPPL PPPP PG PPP LG P G P
Sbjct: 550 PPPPPPPLPGGMLPPPPPPLPPGGPPPP-PG----PPP--------LGAIMPPPGAPMGL 596
Query: 905 TKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSKEL 960
KKK+I N ++ F+W + +W++++ KV D LE F + ++
Sbjct: 597 ALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQ 656
Query: 961 -----SVSKKTAADG---------KRQEIIVLDSKRSNAINIGLTVLPPPR-TIKIAILN 1005
S SK+ AD K +E+ V+D +R+ NI L+ L IK AIL
Sbjct: 657 DFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILT 716
Query: 1006 FDEYA-LNKEGIEKILTMIPTDEEKQKIQEAQLANPEIP-LGSAEQFLLTLSSISELSAR 1063
DE L K+ +E++L +P EK I + E+ + A++FL +S I+ R
Sbjct: 717 MDEQEDLPKDMLEQLLKFVP---EKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQR 773
Query: 1064 LHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN---GTNAK 1120
L FK + EV + ++ G +++ + L +L +LA GN++N NA
Sbjct: 774 LQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAY 833
Query: 1121 AFELSYLEKVPEVKDTVHKQ-SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQ 1179
F++S L K+ + K ++ K +LLH++ T+V +P +L E+ I ++AKV+ +L
Sbjct: 834 GFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELD 893
Query: 1180 DNLCQMERRCKA 1191
+ + KA
Sbjct: 894 KEISTLRSGLKA 905
Score = 30.8 bits (68), Expect = 9.8
Identities = 21/91 (23%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 458 ERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRS 517
+ E+ R+E E Q++E++ER + + + Q +EE + L ++ + ++
Sbjct: 451 QAEKMRKEHNELQQKLEKKER---------ECDAKTQEKEEMMQTLNKMKEKLEKETTEH 501
Query: 518 RSVSRGRADLSLDLTSPAAPACLAPLSHSPS 548
+ V + ADL+ L + A A + PS
Sbjct: 502 KQVKQQVADLTAQLHELSRRAVCASIPGGPS 532
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 127 bits (319), Expect = 8e-29
Identities = 157/688 (22%), Positives = 271/688 (39%), Gaps = 121/688 (17%)
Query: 708 DDEEKGDGEAGRTQQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAE 767
+D E + ++ E VA L R+ + S + + ++ R ++ E
Sbjct: 389 EDTETKNAVLEHMEELQEQVALLTERLRDAENESMAK---IAELEKQLSQARKELETLRE 445
Query: 768 KFNSGDLGRGSISPDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDL-- 825
+F+ S P EP +K P AP +P EL++++++ L
Sbjct: 446 RFSESTAMGASRRPP-EP-EKAPPAAPTRPSA-------------LELKVEELEEKGLIR 490
Query: 826 -----GEEDDIDVLDVDLGH------------------------REAPGPPPPPPPTFLG 856
G+ I++L V + APG PPPPP G
Sbjct: 491 ILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPG 550
Query: 857 LP---------------------PPPPPPLLDSIPPP------------PVPGNLLVPPP 883
LP PPP PPL +PPP PVP PPP
Sbjct: 551 LPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPP 610
Query: 884 PVFNAPQGLGWSQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIK 943
P P LG G K KK I+ + + +W + ++++L K
Sbjct: 611 PPGGPPDALGRRDSELGPG--VKAKKPIQTKF-RMPLLNWVALKPSQITGTVFTELNDEK 667
Query: 944 V----DTSRLEHLFESKSK----ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLP- 994
V D S E F++KS+ +LS K AA + ++++ R A N+ +T+
Sbjct: 668 VLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANR--AKNLAITLRKG 725
Query: 995 --PPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQL-ANPEIPLGSAEQFL 1051
I AI +D AL + +E ++ +PT+ E+ I + P L ++F+
Sbjct: 726 NLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFM 785
Query: 1052 LTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIG 1111
L S I L R+ F ++ T + + L + ++++ L IL +LA G
Sbjct: 786 LCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFG 845
Query: 1112 NFLNGTN---AKAFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAIT 1168
N++N + A F L L+ + E+K T KQ+LLH++ ++ E +P + +S++ +
Sbjct: 846 NYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLD 905
Query: 1169 RSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKI 1228
++ V D + ++ ++R + + + + + VLK EFL+ + + L
Sbjct: 906 KAGSVSLDSVLADVRSLQRGLELT---QREFVRQDDCMVLK----EFLRANSPTMDKLLA 958
Query: 1229 VHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHR 1288
+ F S + + G P + + F + S F Y+ + V Q K++ A
Sbjct: 959 DSKTAQEAFESVVEYFGENP---KTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQE 1015
Query: 1289 ERNKTRGKMITDSGKFSGSSPAPPSQPQ 1316
T GK G PAP S P+
Sbjct: 1016 AGADTPGK---------GEPPAPKSPPK 1034
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 127 bits (318), Expect = 1e-28
Identities = 106/361 (29%), Positives = 172/361 (47%), Gaps = 26/361 (7%)
Query: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPTFT 905
PPPPPP F PPPPPPPL PP P PG PP GL Q P
Sbjct: 541 PPPPPPLPFACCPPPPPPPLPPGGPPTP-PG-----APPCLG--MGLPLPQDPYPSSDVP 592
Query: 906 KKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV-------DTSRLEHLFESKSK 958
+KK + + ++ F+W N R +W++++ ++V D ++ ++ K
Sbjct: 593 LRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQK 652
Query: 959 EL-SVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLP-PPRTIKIAILNFDEYA-LNKEG 1015
EL S A K +E+ V+D +R+ I L+ L I+ AIL DE L K+
Sbjct: 653 ELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDM 712
Query: 1016 IEKILTMIPTDEEKQKIQEAQLANPEIP-LGSAEQFLLTLSSISELSARLHLWAFKMDYE 1074
+E++L IP EK I + EI + A++FL +S I RL FK ++
Sbjct: 713 LEQLLKFIP---EKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQ 769
Query: 1075 TTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN---GTNAKAFELSYLEKVP 1131
E + + +L +K L +L +LAIGNF+N A F ++ L K+
Sbjct: 770 ERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIA 829
Query: 1132 EVKDTVHKQ-SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCK 1190
+ K ++ + SLLH++ ++ ++FPD ++ SE+ + +AKV+ +L+ + + R +
Sbjct: 830 DTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLR 889
Query: 1191 A 1191
A
Sbjct: 890 A 890
Score = 32.0 bits (71), Expect = 4.4
Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 15/152 (9%)
Query: 430 PQEARLERSSPSGLLTSSFRQHQ-ESLAAERERRRQEREERLQRIEREERNKFSRDYLDK 488
P A LE + ++ +++ + + E+ R+E E + R+ER+ER ++ L+K
Sbjct: 418 PDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKT-LEK 476
Query: 489 REEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAA--PACLAPLSHS 546
E R K ++LA E E V+ A LS T P + P PL+ S
Sbjct: 477 EEMMRTLN----KMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLS 532
Query: 547 PSSSDSQEALTVSASSPGTPHHPQASAGDPEP 578
S +T + P P P A P P
Sbjct: 533 SS-------MTTNDLPPPPPPLPFACCPPPPP 557
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 123 bits (309), Expect = 1e-27
Identities = 127/510 (24%), Positives = 230/510 (45%), Gaps = 70/510 (13%)
Query: 838 LGHREAPGPPPPPPPTFLGLPPPP-----PPPLL-----DSIPPPPVPGNLLVPPPPVFN 887
+G AP PP PPP T G+PPPP PPLL ++P P V G L PPP+ +
Sbjct: 1215 MGIPPAPAPPLPPPGT--GIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFL---PPPLPS 1269
Query: 888 APQGLGWSQVPRGQPTFTKKKKTIR-LFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDT 946
GLG +Q + + + ++ L+W ++ +W K+E +D
Sbjct: 1270 GLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLH----SKRDSSTSLIWEKIEEPSIDC 1325
Query: 947 SRLEHLFES---KSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLP-PPRTIKIA 1002
E LF K ++ +S + +Q + +L +KRS A+ I ++ L + I+ A
Sbjct: 1326 HEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHA 1385
Query: 1003 ILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPE----IPLGSAEQFLLTLSSIS 1058
++N D ++ E ++ + +E +KI++ ++ + L EQFL LS I
Sbjct: 1386 VVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIP 1445
Query: 1059 ELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTN 1118
S R+ F+ + + + L L++ + L+N + +L +LA GN++NG N
Sbjct: 1446 NFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGN 1505
Query: 1119 -----AKAFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENF-------------PDSSDL 1160
A F L L K+ +VK + + +SLL ++ + + NF P+ DL
Sbjct: 1506 KTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDL 1565
Query: 1161 YSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCA 1220
+ +++++ F+ Q +L ++++ KA ++A +++ K+ M F ++
Sbjct: 1566 F-------QASQMKFEDFQKDLRKLKKDLKAC--EVEAGKVYQVSS--KEHMQPFKENME 1614
Query: 1221 ERIIILKI---VHRRIINRFHSFLL-----FMGHPPYAIREVNINKFCRIISEFALEY-- 1270
+ II KI + H L F P +EV+ N F I EF+ ++
Sbjct: 1615 QFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKD 1674
Query: 1271 --RTTRERVLQQKQKRANHRERNKTRGKMI 1298
+ + +LQ++ K A R K +GK +
Sbjct: 1675 FWKKENKLLLQERVKEAEEVCRQK-KGKSL 1703
Score = 56.6 bits (135), Expect = 2e-07
Identities = 23/41 (56%), Positives = 28/41 (68%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P + PPPP+PG + PPPP+
Sbjct: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPL 1168
Score = 55.8 bits (133), Expect = 3e-07
Identities = 23/41 (56%), Positives = 28/41 (68%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P + PPPP+PG + PPPP+
Sbjct: 1084 GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL 1124
Score = 55.8 bits (133), Expect = 3e-07
Identities = 23/41 (56%), Positives = 28/41 (68%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP +G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1095 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1135
Score = 55.8 bits (133), Expect = 3e-07
Identities = 23/41 (56%), Positives = 28/41 (68%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP +G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1139 GIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1179
Score = 55.5 bits (132), Expect = 4e-07
Identities = 23/41 (56%), Positives = 28/41 (68%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P + PPPP+PG + PPPP+
Sbjct: 1161 GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPL 1201
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 974 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1014
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 985 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1025
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 996 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1036
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1007 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1047
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1018 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1058
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1069
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1040 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1080
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1051 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1091
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1062 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1102
Score = 55.1 bits (131), Expect = 5e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1106 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1146
Score = 54.7 bits (130), Expect = 6e-07
Identities = 22/40 (55%), Positives = 27/40 (67%)
Query: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
PPPPPP G+PPPPP P +P PP+PG + PPPP+
Sbjct: 909 PPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPL 948
Score = 54.7 bits (130), Expect = 6e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1073 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1113
Score = 54.7 bits (130), Expect = 6e-07
Identities = 23/41 (56%), Positives = 27/41 (65%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 1150 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1190
Score = 51.6 bits (122), Expect = 5e-06
Identities = 22/41 (53%), Positives = 26/41 (63%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP G+PPPPP P PPPP+P + PPPP+
Sbjct: 1117 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPL 1157
Score = 51.2 bits (121), Expect = 7e-06
Identities = 22/41 (53%), Positives = 26/41 (63%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G P PPP G+PPPPP P PPPP+PG + PPPP+
Sbjct: 963 GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1003
Score = 50.1 bits (118), Expect = 2e-05
Identities = 21/39 (53%), Positives = 25/39 (64%)
Query: 847 PPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
PPPPP G+P PPP P PPPP+PG + PPPP+
Sbjct: 954 PPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPL 992
Score = 48.9 bits (115), Expect = 3e-05
Identities = 21/41 (51%), Positives = 25/41 (60%)
Query: 845 GPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
G PPPPP +PPPPP P PPP+PG + PPPP+
Sbjct: 941 GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPL 981
Score = 47.0 bits (110), Expect = 1e-04
Identities = 24/48 (50%), Positives = 27/48 (56%), Gaps = 7/48 (14%)
Query: 844 PGPPP------PPPPTFLGLPPPPPPPLLDS-IPPPPVPGNLLVPPPP 884
P PPP PPPP G PPPPPL + IPPPP + +PPPP
Sbjct: 1108 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155
Score = 45.4 bits (106), Expect = 4e-04
Identities = 23/50 (46%), Positives = 27/50 (54%), Gaps = 8/50 (16%)
Query: 844 PGPPP------PPPPTF--LGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
P PPP PPPP G+ P PP P PPPP+PG + PPPP+
Sbjct: 910 PPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPL 959
Score = 45.1 bits (105), Expect = 5e-04
Identities = 23/50 (46%), Positives = 27/50 (54%), Gaps = 10/50 (20%)
Query: 846 PPPPPP------PTFLGLPPPPPPPLLDS----IPPPPVPGNLLVPPPPV 885
PPPPPP PT P PPPL + PPPP+PG + PPPP+
Sbjct: 877 PPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPL 926
Score = 44.7 bits (104), Expect = 7e-04
Identities = 22/49 (44%), Positives = 26/49 (53%), Gaps = 9/49 (18%)
Query: 846 PPPP---------PPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPV 885
PPPP PP G+PPPPP P PPPP+PG + PPP+
Sbjct: 922 PPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPL 970
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/62 (40%), Positives = 33/62 (53%), Gaps = 6/62 (9%)
Query: 847 PPPPPPTFLGLPPPPPPPLLDS--IPPPPVPGNLLVPPPPVFNA----PQGLGWSQVPRG 900
P PPP + PPPPPPL + PPPP+PG ++P PP+ A P L + +P
Sbjct: 897 PQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956
Query: 901 QP 902
P
Sbjct: 957 PP 958
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/57 (40%), Positives = 30/57 (52%), Gaps = 18/57 (31%)
Query: 846 PPPPPPPTF--------LGLPPPPPPPL----LDSIP------PPPVPGNLLVPPPP 884
P PPP P LG+ PPPPPPL + ++P PPP+ G ++PPPP
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPP 912
Score = 33.5 bits (75), Expect = 1.5
Identities = 33/136 (24%), Positives = 58/136 (42%), Gaps = 10/136 (7%)
Query: 507 AAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVSASSPGTP 566
A E L S+++ G D + L + L+ + SD++ A + PG P
Sbjct: 90 AGGSREDVLDSQALQTGELDSAHSLLTKTPDLSLS--ADEAGLSDTECADPFEVTGPGGP 147
Query: 567 HHPQASAGDPEPESEAEPEAEAGAGQ-VADEAGQDIASAHEGAETE-----VEQA--LEQ 618
+A G + E A A GQ + + DI S H E E ++QA L+Q
Sbjct: 148 GPAEARVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLLSDIQQAIRLQQ 207
Query: 619 EPEERASLSEKERQNE 634
+ +++ L +++Q +
Sbjct: 208 QQQQQLQLQLQQQQQQ 223
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 120 bits (302), Expect = 7e-27
Identities = 116/466 (24%), Positives = 203/466 (43%), Gaps = 38/466 (8%)
Query: 844 PGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPG---------NLLVPPPPVFNAPQGLGW 894
P PPP PPP+ G PPPPPPP L + P PP PG L PPPP G
Sbjct: 685 PPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSS 744
Query: 895 SQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKL-EPIKVDTSRLEHLF 953
SQ PR +P L+W ++ D ++ LW L EP D S E+LF
Sbjct: 745 SQCPR-KPAIEPSCPMKPLYWTRIQISD----RSQNATPTLWDSLEEPDIRDPSEFEYLF 799
Query: 954 E---SKSKELSVSKKTAADGKRQEII-VLDSKRSNAINIGLTVLP-PPRTIKIAILNFDE 1008
++ K+ +S+ K ++II +LD KRS + I ++ L + I+ AI N D+
Sbjct: 800 SKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDD 859
Query: 1009 YALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIP---LGSAEQFLLTLSSISELSARLH 1065
++ E + + ++E KI++ + E L EQFL L+ I + R
Sbjct: 860 SVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQ 919
Query: 1066 LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTN-----AK 1120
F+ + + + + L + K++ IL+ +LA GN++NG N A
Sbjct: 920 CIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQAD 979
Query: 1121 AFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITR------SAKVD 1174
+ L L K+ +VK + +L+ +V + + + + + +++V
Sbjct: 980 GYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVK 1039
Query: 1175 FDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVL---KQRMSEFLKDCAERIIILKIVHR 1231
F+ L +L +++R+ +AS + + K K L K ++ EF + + + +
Sbjct: 1040 FEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLE 1099
Query: 1232 RIINRFHSFLLFMG-HPPYAIREVNINKFCRIISEFALEYRTTRER 1276
F + + + G P +E+ + + EF +++T +R
Sbjct: 1100 NAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKR 1145
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 116 bits (291), Expect = 1e-25
Identities = 91/350 (26%), Positives = 170/350 (48%), Gaps = 31/350 (8%)
Query: 847 PPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQ---GLGWSQVPRGQPT 903
P PPP L LPPPP PPL PPPP+P PP AP +G S + +P
Sbjct: 457 PAPPPEEVLPLPPPPAPPL--PPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPI 514
Query: 904 FTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSK- 958
TK + + F+W + ++S+L+ K+ D + E LF++K++
Sbjct: 515 KTKFRLPV---------FNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQG 565
Query: 959 ---ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRT---IKIAILNFDEYALN 1012
+L SK A ++ +L++ R A N+ +T+ R+ I AI FD L
Sbjct: 566 PALDLICSKNKTAQKAASKVTLLEANR--AKNLAITLRKAGRSAEEICRAIHTFDLQTLP 623
Query: 1013 KEGIEKILTMIPTDEEKQKIQEAQL-ANPEIPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
+ +E ++ +PT+ E + +++ + P L + ++F+L S + L+ R+ AF
Sbjct: 624 VDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLG 683
Query: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---FELSYLE 1128
+++ + + L + +++++ L +L +LA+GN++N + A F+L L+
Sbjct: 684 NFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLD 743
Query: 1129 KVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQL 1178
+ + K T K +LLH + V E +PD ++ + E+ + ++A V + +
Sbjct: 744 LLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV 793
Score = 33.1 bits (74), Expect = 2.0
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 3/108 (2%)
Query: 395 DLREKYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLTSSFRQHQES 454
D ++ + +Y++ G S TTP S V P R RS + R+ QE
Sbjct: 831 DKLQRDAKTAEEAYNAVVRYFGESPKTTPPS-VFFPVFVRFIRSYKEAEQENEARKKQEE 889
Query: 455 LAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKY 502
+ RE++ + ++L +RNK+ + L +RQA+E R Y
Sbjct: 890 VM--REKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVY 935
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 116 bits (291), Expect = 1e-25
Identities = 91/350 (26%), Positives = 170/350 (48%), Gaps = 31/350 (8%)
Query: 847 PPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQ---GLGWSQVPRGQPT 903
P PPP L LPPPP PPL PPPP+P PP AP +G S + +P
Sbjct: 508 PAPPPEEVLPLPPPPAPPL--PPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPI 565
Query: 904 FTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSK- 958
TK + + F+W + ++S+L+ K+ D + E LF++K++
Sbjct: 566 KTKFRLPV---------FNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQG 616
Query: 959 ---ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRT---IKIAILNFDEYALN 1012
+L SK A ++ +L++ R A N+ +T+ R+ I AI FD L
Sbjct: 617 PALDLICSKNKTAQKAASKVTLLEANR--AKNLAITLRKAGRSAEEICRAIHTFDLQTLP 674
Query: 1013 KEGIEKILTMIPTDEEKQKIQEAQL-ANPEIPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
+ +E ++ +PT+ E + +++ + P L + ++F+L S + L+ R+ AF
Sbjct: 675 VDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLG 734
Query: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---FELSYLE 1128
+++ + + L + +++++ L +L +LA+GN++N + A F+L L+
Sbjct: 735 NFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLD 794
Query: 1129 KVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQL 1178
+ + K T K +LLH + V E +PD ++ + E+ + ++A V + +
Sbjct: 795 LLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENV 844
Score = 33.1 bits (74), Expect = 2.0
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 3/108 (2%)
Query: 395 DLREKYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLTSSFRQHQES 454
D ++ + +Y++ G S TTP S V P R RS + R+ QE
Sbjct: 882 DKLQRDAKTAEEAYNAVVRYFGESPKTTPPS-VFFPVFVRFIRSYKEAEQENEARKKQEE 940
Query: 455 LAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKY 502
+ RE++ + ++L +RNK+ + L +RQA+E R Y
Sbjct: 941 VM--REKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVY 986
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 115 bits (287), Expect = 4e-25
Identities = 112/467 (23%), Positives = 221/467 (47%), Gaps = 47/467 (10%)
Query: 844 PGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPG----NLLVPP--PPVFNAPQGLGWSQ- 896
P PPPPPPP PPPPPPP PPPP+PG + PP PP+ +AP G S
Sbjct: 553 PPPPPPPPPP----PPPPPPP-----PPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSP 603
Query: 897 --VPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLE 950
V K KK I+ + + F+W + ++++++ ++ + E
Sbjct: 604 TVVFNSGLAAVKIKKPIKTKF-RMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFE 662
Query: 951 HLFESKSK----ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRT---IKIAI 1003
+F++K++ +LS SK+ ++ +L++ R A N+ +T+ +T I AI
Sbjct: 663 EIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANR--AKNLAITLRKAGKTADEICKAI 720
Query: 1004 LNFDEYALNKEGIEKILTMIPTDEEKQKIQ-EAQLANPEIPLGSAEQFLLTLSSISELSA 1062
FD L + +E ++ +PT+ E + ++ + P L ++F++ S I L
Sbjct: 721 HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ 780
Query: 1063 RLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA- 1121
++ + AF ++ + + + L + +++++ L IL +LA+GN++N + A
Sbjct: 781 KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV 840
Query: 1122 --FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQ 1179
F+L L+ + + K T KQ+LLH++ +V E + S Y+E+ + ++A V + +
Sbjct: 841 YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL 900
Query: 1180 DNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHS 1239
++ +++R + + H+ +LK EF+ + ++ L+ + + F
Sbjct: 901 LDVKELQRGMDLT---KREYTMHDHNTLLK----EFILNNEGKLKKLQDDAKIAQDAFDD 953
Query: 1240 FLLFMGHPPYAIREVNINKFCRIISEFALEYR-TTRERVLQQKQKRA 1285
+ + G P + + F + F Y+ E L++KQ++A
Sbjct: 954 VVKYFGENP---KTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQA 997
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 107 bits (268), Expect = 6e-23
Identities = 117/506 (23%), Positives = 212/506 (41%), Gaps = 67/506 (13%)
Query: 838 LGHREAPGPPPPPPPTFLGLPPP--------------PPPPLLDSIPPPPVPGNLLVPPP 883
+G P PPPPPPP PPP PPPP PPPP+PG +PPP
Sbjct: 26 IGQTPPPAPPPPPPP-----PPPSPPCSCSREECPSSPPPP-----PPPPLPGEPPIPPP 75
Query: 884 PVFNAPQGLGWSQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWS----KL 939
P GL + G KKK+ FW + K N +W+ +
Sbjct: 76 -----PPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTN------IWTLAARQE 124
Query: 940 EPIKVDTSRLEHLF--ESKSKELSVSKK-----TAADGKRQEIIVLDSKRSNAINIGLTV 992
++DT +E LF + + + S+ ++ ++ R+EI +LD+KRS I I L
Sbjct: 125 HHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQ 184
Query: 993 L-PPPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFL 1051
PR+I I E + + L +P EE +K++ + L A+ FL
Sbjct: 185 FKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLK--AFSGDVSKLSLADSFL 242
Query: 1052 LTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIG 1111
L + S R+ K ++ + + + L+ I +L + + L IL +L G
Sbjct: 243 YGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAG 302
Query: 1112 NFLN----GTNAKAFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAI 1167
N +N NA F+LS L K+ + K +LLH V + + ++ +
Sbjct: 303 NIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHV 362
Query: 1168 TRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILK 1227
++A++ + + L + R K+ ++++ + L Q+M +FL+ E++ L+
Sbjct: 363 QKTARLSLENTEAELHLLFVRTKSLKENIQRDGE------LCQQMEDFLQFAIEKLRELE 416
Query: 1228 IVHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEY----RTTRERVLQQ-KQ 1282
+ + + ++ + F + + +++ +I +F ++ + +R Q+ +Q
Sbjct: 417 CWKQELQDEAYTLIDFFCEDK---KTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQ 473
Query: 1283 KRANHRERNKTRGKMITDSGKFSGSS 1308
+ + K R + G F SS
Sbjct: 474 LQRLKEQEQKQRSWATGELGAFGRSS 499
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 98.6 bits (244), Expect = 4e-20
Identities = 100/372 (26%), Positives = 162/372 (43%), Gaps = 36/372 (9%)
Query: 845 GPPPPPPPTFLGL---PPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQ 901
G PPPPPP G+ PPPPPPPLL PPV G + V GLG + VP +
Sbjct: 498 GCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGM--EEVIVAQVDHGLGSAWVPSHR 555
Query: 902 PTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKL-----EPIKVDTSRLEHLFE-- 954
+ +L W ++ N R +W+ L E ++ D S +E LF
Sbjct: 556 RVNPPTLRMKKLNWQKLP------SNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFP 609
Query: 955 -SKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNF-DEYALN 1012
+K KE ++ A + +EI LD+K+S +NI L A++ D +
Sbjct: 610 AAKPKEPTMVAPRARK-EPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFD 668
Query: 1013 KEGIEKILTMIPTDEEKQKIQEAQLANPE-IPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
E ++++L ++P EK +I+ + E L SA+ F L L +I R+
Sbjct: 669 VEVLKQLLKLLP---EKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCE 725
Query: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN----GTNAKAFELSYL 1127
V + + L ++ L +L IGNFLN +A F++S L
Sbjct: 726 GAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTL 785
Query: 1128 EKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQD------- 1180
K+ E K ++ +LLHHV ++ PD L ++ +++A ++ + ++
Sbjct: 786 LKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLK 845
Query: 1181 NLCQMERRCKAS 1192
L + ER+ AS
Sbjct: 846 KLLETERKVSAS 857
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 98.6 bits (244), Expect = 4e-20
Identities = 100/372 (26%), Positives = 162/372 (43%), Gaps = 36/372 (9%)
Query: 845 GPPPPPPPTFLGL---PPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQ 901
G PPPPPP G+ PPPPPPPLL PPV G + V GLG + VP +
Sbjct: 498 GCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGM--EEVIVAQVDHGLGSAWVPSHR 555
Query: 902 PTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKL-----EPIKVDTSRLEHLFE-- 954
+ +L W ++ N R +W+ L E ++ D S +E LF
Sbjct: 556 RVNPPTLRMKKLNWQKLP------SNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFP 609
Query: 955 -SKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNF-DEYALN 1012
+K KE ++ A + +EI LD+K+S +NI L A++ D +
Sbjct: 610 AAKPKEPTMVAPRARK-EPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFD 668
Query: 1013 KEGIEKILTMIPTDEEKQKIQEAQLANPE-IPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
E ++++L ++P EK +I+ + E L SA+ F L L +I R+
Sbjct: 669 VEVLKQLLKLLP---EKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCE 725
Query: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN----GTNAKAFELSYL 1127
V + + L ++ L +L IGNFLN +A F++S L
Sbjct: 726 GAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTL 785
Query: 1128 EKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQD------- 1180
K+ E K ++ +LLHHV ++ PD L ++ +++A ++ + ++
Sbjct: 786 LKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLK 845
Query: 1181 NLCQMERRCKAS 1192
L + ER+ AS
Sbjct: 846 KLLETERKVSAS 857
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 91.3 bits (225), Expect = 6e-18
Identities = 108/479 (22%), Positives = 189/479 (39%), Gaps = 81/479 (16%)
Query: 846 PPPPPPPTFLG----------------------------LPPPPPPPLLDSIPPPPVPGN 877
PPPPPP F +PPPPPPPL PPPVP
Sbjct: 756 PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL-----PPPVPC- 809
Query: 878 LLVPPPPVFNAPQGLGWSQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWS 937
PP+ + +GLG + + T RL W +V + +W
Sbjct: 810 ----APPMLS--RGLGHRR------SETSHMSVKRLRWEQVENSEGT----------IWG 847
Query: 938 KLEPIKVDTSRLEHLFESKSKELSVSKKTAADG--------KRQEIIVLDSKRSNAINIG 989
+L D +L + + EL + A K++ + +L K++ +I
Sbjct: 848 QLGEDS-DYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSIL 906
Query: 990 LTVLP-PPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAE 1048
L L P ++ +++ + L + ++L P +E+Q+ Q + A L +
Sbjct: 907 LAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGR--LSEPD 964
Query: 1049 QFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLL 1108
QF+L + S+ E RL F+ + +E+ L L++ +L+N++ L IL +L
Sbjct: 965 QFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVL 1024
Query: 1109 AIGNFLNGTNAK-----AFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSE 1163
A+GN+LN K F++++L ++ K K + LH + + ++FP+ +
Sbjct: 1025 AMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQD 1084
Query: 1164 IGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERI 1223
+ + +AKV+ L +L + D ++I+ + MS FL+ +
Sbjct: 1085 LPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISP-SSEDKFAMVMSSFLETAQPAL 1143
Query: 1224 IILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQ 1282
L + R + L F G A F I +EF ++ ER L Q
Sbjct: 1144 RALDGLQREAMEELGKALAFFGEDSKA---TTSEAFFGIFAEFMSKF----ERALSDLQ 1195
Score = 30.8 bits (68), Expect = 9.8
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 3/64 (4%)
Query: 455 LAAERERRRQEREERLQRIEREERNK---FSRDYLDKREEQRQAREERYKYLEQLAAEEH 511
LA RE R +R + RE R K FSR + +Q A+E+ + L+Q AAE+
Sbjct: 111 LALGRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQR 170
Query: 512 EKEL 515
+L
Sbjct: 171 VDDL 174
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 61.2 bits (147), Expect = 7e-09
Identities = 64/260 (24%), Positives = 117/260 (45%), Gaps = 30/260 (11%)
Query: 431 QEARLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKFSRDYL--DK 488
++ + ++ PS + ++ L E ER+++E EER++R+E E + + L +K
Sbjct: 327 EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEK 386
Query: 489 REEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSP---AAPACLAPLSH 545
RE ++Q +ER + L+ +E + +S+ +R RA+ +L L P+ +
Sbjct: 387 RERKKQKEKERKERLK----KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKK 442
Query: 546 SPSSSDSQ--------EALTVSASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEA 597
P D + E+ VS S G PE E E P E + ++A
Sbjct: 443 RPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE-ETPPPVEPEEEEDTEDA 501
Query: 598 GQD----IASAHEGAETE---VEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSS 650
G D +AS E + E V +++ PEE E+E ++E E + S S
Sbjct: 502 GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGS- 560
Query: 651 SSTLEREEKEDKLSRDRTTG 670
E +E+++K+S ++ +G
Sbjct: 561 ----EGDEEDEKVSDEKDSG 576
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 58.9 bits (141), Expect = 3e-08
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 30/300 (10%)
Query: 387 SFKPNQVRDLREKYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQE-ARLERSSPSGLLT 445
S + ++RD R + + NS + S + ++ PPQ+ +R E+
Sbjct: 13 SLEEGELRDHRMEITI--RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEK 70
Query: 446 SSFRQHQESLAAERE-----RRRQEREERLQRIEREERNKFSRDYLDK---REEQRQARE 497
++H ERE R R+E+++ + ER++R + +R++ + R EQ + +
Sbjct: 71 RKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR 130
Query: 498 ERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALT 557
ER + + + E+ E++ R R R + A H D + +
Sbjct: 131 ERERKMREQQKEQREQKERERRAEERRKEREARREVSA--------HHRTMREDYSDKVK 182
Query: 558 VS--ASSPGTPHHPQASAGD-PEPESEAEPEAEAGAGQVAD-------EAGQDIASAHEG 607
S + SP P + GD +P E + E + D + + +SA G
Sbjct: 183 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 242
Query: 608 AETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREE-KEDKLSRD 666
+ +E E+ E+E EE S SE+ + E E + S S +S EE E+++S D
Sbjct: 243 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 302
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/230 (24%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R +E A RE RQ+R E + R ER++ + KRE +R+ RE++ + EQ
Sbjct: 91 RHREEQDKARREWERQKRREMAREHSRRERDRLEQ-LERKRERERKMREQQKEQREQKER 149
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSPGTP 566
E +E R +R H D + + S + SP P
Sbjct: 150 ERRAEERRKEREARREVSAH----------------HRTMREDYSDKVKASHWSRSPPRP 193
Query: 567 HHPQASAGDP-EPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQALEQ 618
+ GD +P E + E + D + + +SA G+ +E E+ E+
Sbjct: 194 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 253
Query: 619 EPEERASLSEKERQNEGVNERD------NCSASSVSSSSSTLEREEKEDK 662
E EE S SE+ + E E + N +S S+ E E ED+
Sbjct: 254 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 303
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/200 (25%), Positives = 86/200 (43%), Gaps = 17/200 (8%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQA----REERYKYLE 504
R E L +RER R+ RE++ ++ E++ER + + + +RE +R+ R R Y +
Sbjct: 120 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 179
Query: 505 QLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAP---LSHSPSSSDSQEALTVSAS 561
++ A + R R +L D P + LS SDS+ + + S
Sbjct: 180 KVKASHWSRS--PPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 236
Query: 562 SPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPE 621
S S + E E E E E E + ++E ++ E + E+A EQ E
Sbjct: 237 SSA----ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 292
Query: 622 ERASLSEKERQNEGVNERDN 641
E +SE+E + E +N
Sbjct: 293 E---VSEEEMSEDEERENEN 309
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 58.5 bits (140), Expect = 4e-08
Identities = 57/234 (24%), Positives = 99/234 (42%), Gaps = 25/234 (10%)
Query: 450 QHQESLAAERERRRQEREER---LQRIEREERNKFSRDYLDK---REEQRQAREERYKYL 503
+H E ERR++ REE+ + ER++R + +R++ + R EQ + + ER + +
Sbjct: 110 KHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 169
Query: 504 EQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--AS 561
+ E+ E++ R R R + A H D + + S +
Sbjct: 170 REQQKEQREQKERERRAEERRKEREARREVSA--------HHRTMREDYSDKVKASHWSR 221
Query: 562 SPGTPHHPQASAGD-PEPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVE 613
SP P + GD +P E + E + D + + +SA G+ +E E
Sbjct: 222 SPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 281
Query: 614 QALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREE-KEDKLSRD 666
+ E+E EE S SE+ + E E + S S +S EE E+++S D
Sbjct: 282 EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 335
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/230 (24%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R +E A RE RQ+R E + R ER++ + KRE +R+ RE++ + EQ
Sbjct: 124 RHREEQDKARREWERQKRREMAREHSRRERDRLEQ-LERKRERERKMREQQKEQREQKER 182
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSPGTP 566
E +E R +R H D + + S + SP P
Sbjct: 183 ERRAEERRKEREARREVSAH----------------HRTMREDYSDKVKASHWSRSPPRP 226
Query: 567 HHPQASAGDP-EPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQALEQ 618
+ GD +P E + E + D + + +SA G+ +E E+ E+
Sbjct: 227 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 286
Query: 619 EPEERASLSEKERQNEGVNERD------NCSASSVSSSSSTLEREEKEDK 662
E EE S SE+ + E E + N +S S+ E E ED+
Sbjct: 287 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 336
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/200 (25%), Positives = 86/200 (43%), Gaps = 17/200 (8%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQA----REERYKYLE 504
R E L +RER R+ RE++ ++ E++ER + + + +RE +R+ R R Y +
Sbjct: 153 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 212
Query: 505 QLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAP---LSHSPSSSDSQEALTVSAS 561
++ A + R R +L D P + LS SDS+ + + S
Sbjct: 213 KVKASHWSRS--PPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 269
Query: 562 SPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPE 621
S S + E E E E E E + ++E ++ E + E+A EQ E
Sbjct: 270 SSA----ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 325
Query: 622 ERASLSEKERQNEGVNERDN 641
E +SE+E + E +N
Sbjct: 326 E---VSEEEMSEDEERENEN 342
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 58.5 bits (140), Expect = 4e-08
Identities = 55/232 (23%), Positives = 100/232 (43%), Gaps = 27/232 (11%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDK---REEQRQAREERYKYLEQ 505
R+H+ R+R R+E+++ + ER++R + +R++ + R EQ + + ER + + +
Sbjct: 118 REHER-----RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 172
Query: 506 LAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSP 563
E+ E++ R R R + A H D + + S + SP
Sbjct: 173 QQKEQREQKERERRAEERRKEREARREVSA--------HHRTMREDYSDKVKASHWSRSP 224
Query: 564 GTPHHPQASAGD-PEPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQA 615
P + GD +P E + E + D + + +SA G+ +E E+
Sbjct: 225 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 284
Query: 616 LEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREE-KEDKLSRD 666
E+E EE S SE+ + E E + S S +S EE E+++S D
Sbjct: 285 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 336
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/230 (24%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R +E A RE RQ+R E + R ER++ + KRE +R+ RE++ + EQ
Sbjct: 125 RHREEQDKARREWERQKRREMAREHSRRERDRLEQ-LERKRERERKMREQQKEQREQKER 183
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSPGTP 566
E +E R +R H D + + S + SP P
Sbjct: 184 ERRAEERRKEREARREVSAH----------------HRTMREDYSDKVKASHWSRSPPRP 227
Query: 567 HHPQASAGDP-EPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQALEQ 618
+ GD +P E + E + D + + +SA G+ +E E+ E+
Sbjct: 228 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 287
Query: 619 EPEERASLSEKERQNEGVNERD------NCSASSVSSSSSTLEREEKEDK 662
E EE S SE+ + E E + N +S S+ E E ED+
Sbjct: 288 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 337
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/200 (25%), Positives = 86/200 (43%), Gaps = 17/200 (8%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQA----REERYKYLE 504
R E L +RER R+ RE++ ++ E++ER + + + +RE +R+ R R Y +
Sbjct: 154 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 213
Query: 505 QLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAP---LSHSPSSSDSQEALTVSAS 561
++ A + R R +L D P + LS SDS+ + + S
Sbjct: 214 KVKASHWSRS--PPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 270
Query: 562 SPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPE 621
S S + E E E E E E + ++E ++ E + E+A EQ E
Sbjct: 271 SSA----ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 326
Query: 622 ERASLSEKERQNEGVNERDN 641
E +SE+E + E +N
Sbjct: 327 E---VSEEEMSEDEERENEN 343
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 58.5 bits (140), Expect = 4e-08
Identities = 55/232 (23%), Positives = 100/232 (43%), Gaps = 27/232 (11%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDK---REEQRQAREERYKYLEQ 505
R+H+ R+R R+E+++ + ER++R + +R++ + R EQ + + ER + + +
Sbjct: 95 REHER-----RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 149
Query: 506 LAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSP 563
E+ E++ R R R + A H D + + S + SP
Sbjct: 150 QQKEQREQKERERRAEERRKEREARREVSA--------HHRTMREDYSDKVKASHWSRSP 201
Query: 564 GTPHHPQASAGD-PEPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQA 615
P + GD +P E + E + D + + +SA G+ +E E+
Sbjct: 202 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 261
Query: 616 LEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREE-KEDKLSRD 666
E+E EE S SE+ + E E + S S +S EE E+++S D
Sbjct: 262 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 313
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/230 (24%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R +E A RE RQ+R E + R ER++ + KRE +R+ RE++ + EQ
Sbjct: 102 RHREEQDKARREWERQKRREMAREHSRRERDRLEQ-LERKRERERKMREQQKEQREQKER 160
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSPGTP 566
E +E R +R H D + + S + SP P
Sbjct: 161 ERRAEERRKEREARREVSAH----------------HRTMREDYSDKVKASHWSRSPPRP 204
Query: 567 HHPQASAGDP-EPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQALEQ 618
+ GD +P E + E + D + + +SA G+ +E E+ E+
Sbjct: 205 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 264
Query: 619 EPEERASLSEKERQNEGVNERD------NCSASSVSSSSSTLEREEKEDK 662
E EE S SE+ + E E + N +S S+ E E ED+
Sbjct: 265 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 314
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/200 (25%), Positives = 86/200 (43%), Gaps = 17/200 (8%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQA----REERYKYLE 504
R E L +RER R+ RE++ ++ E++ER + + + +RE +R+ R R Y +
Sbjct: 131 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 190
Query: 505 QLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAP---LSHSPSSSDSQEALTVSAS 561
++ A + R R +L D P + LS SDS+ + + S
Sbjct: 191 KVKASHWSRS--PPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 247
Query: 562 SPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPE 621
S S + E E E E E E + ++E ++ E + E+A EQ E
Sbjct: 248 SSA----ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 303
Query: 622 ERASLSEKERQNEGVNERDN 641
E +SE+E + E +N
Sbjct: 304 E---VSEEEMSEDEERENEN 320
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 58.5 bits (140), Expect = 4e-08
Identities = 55/232 (23%), Positives = 100/232 (43%), Gaps = 27/232 (11%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDK---REEQRQAREERYKYLEQ 505
R+H+ R+R R+E+++ + ER++R + +R++ + R EQ + + ER + + +
Sbjct: 129 REHER-----RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 183
Query: 506 LAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSP 563
E+ E++ R R R + A H D + + S + SP
Sbjct: 184 QQKEQREQKERERRAEERRKEREARREVSA--------HHRTMREDYSDKVKASHWSRSP 235
Query: 564 GTPHHPQASAGD-PEPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQA 615
P + GD +P E + E + D + + +SA G+ +E E+
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 295
Query: 616 LEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREE-KEDKLSRD 666
E+E EE S SE+ + E E + S S +S EE E+++S D
Sbjct: 296 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 347
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/230 (24%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R +E A RE RQ+R E + R ER++ + KRE +R+ RE++ + EQ
Sbjct: 136 RHREEQDKARREWERQKRREMAREHSRRERDRLEQ-LERKRERERKMREQQKEQREQKER 194
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSPGTP 566
E +E R +R H D + + S + SP P
Sbjct: 195 ERRAEERRKEREARREVSAH----------------HRTMREDYSDKVKASHWSRSPPRP 238
Query: 567 HHPQASAGDP-EPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQALEQ 618
+ GD +P E + E + D + + +SA G+ +E E+ E+
Sbjct: 239 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 298
Query: 619 EPEERASLSEKERQNEGVNERD------NCSASSVSSSSSTLEREEKEDK 662
E EE S SE+ + E E + N +S S+ E E ED+
Sbjct: 299 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 348
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/200 (25%), Positives = 86/200 (43%), Gaps = 17/200 (8%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQA----REERYKYLE 504
R E L +RER R+ RE++ ++ E++ER + + + +RE +R+ R R Y +
Sbjct: 165 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 224
Query: 505 QLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAP---LSHSPSSSDSQEALTVSAS 561
++ A + R R +L D P + LS SDS+ + + S
Sbjct: 225 KVKASHWSRS--PPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 281
Query: 562 SPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPE 621
S S + E E E E E E + ++E ++ E + E+A EQ E
Sbjct: 282 SSA----ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 337
Query: 622 ERASLSEKERQNEGVNERDN 641
E +SE+E + E +N
Sbjct: 338 E---VSEEEMSEDEERENEN 354
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/230 (24%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R +E A RE RQ+R E + R ER++ + KRE +R+ RE++ + EQ
Sbjct: 134 RHREEQDKARREWERQKRREMAREHSRRERDRLEQ-LERKRERERKMREQQKEQREQKER 192
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVS--ASSPGTP 566
E +E R +R H D + + S + SP P
Sbjct: 193 ERRAEERRKEREARREVSAH----------------HRTMREDYSDKVKASHWSRSPPRP 236
Query: 567 HHPQASAGDP-EPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETEVEQALEQ 618
+ GD +P E + E + D + + +SA G+ +E E+ E+
Sbjct: 237 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 296
Query: 619 EPEERASLSEKERQNEGVNERD------NCSASSVSSSSSTLEREEKEDK 662
E EE S SE+ + E E + N +S S+ E E ED+
Sbjct: 297 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 346
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/236 (24%), Positives = 91/236 (38%), Gaps = 18/236 (7%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDY--LDKREEQRQAREERYKYLEQL 506
R H S + R +ERE ++ REE++K R++ +RE R+ LEQL
Sbjct: 110 RHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL 169
Query: 507 AAE--------EHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTV 558
+ E +KE R + RA+ + SD +A
Sbjct: 170 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 229
Query: 559 SASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVAD-------EAGQDIASAHEGAETE 611
S S P P +P E + E + D + + +SA G+ +E
Sbjct: 230 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 289
Query: 612 VEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREE-KEDKLSRD 666
E+ E+E EE S SE+ + E E + S S +S EE E+++S D
Sbjct: 290 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 345
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/200 (25%), Positives = 86/200 (43%), Gaps = 17/200 (8%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQA----REERYKYLE 504
R E L +RER R+ RE++ ++ E++ER + + + +RE +R+ R R Y +
Sbjct: 163 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 222
Query: 505 QLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAP---LSHSPSSSDSQEALTVSAS 561
++ A + R R +L D P + LS SDS+ + + S
Sbjct: 223 KVKASHWSRS--PPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 279
Query: 562 SPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPE 621
S S + E E E E E E + ++E ++ E + E+A EQ E
Sbjct: 280 SSA----ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 335
Query: 622 ERASLSEKERQNEGVNERDN 641
E +SE+E + E +N
Sbjct: 336 E---VSEEEMSEDEERENEN 352
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 56.6 bits (135), Expect = 2e-07
Identities = 45/149 (30%), Positives = 70/149 (46%), Gaps = 20/149 (13%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R+ QE L + RQER ER +R++RE + + R+ L++ E +RQ RE + EQL
Sbjct: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ----EQLER 253
Query: 509 EEHEKELRSRSVSRGRADLSLDL--------TSPAAPACLAPLSHSPSSSDSQEALTVSA 560
E+ E E R R +S A S++ +S + P A + P+ + SQ+ + +
Sbjct: 254 EQLEWE-RERRISSAAAPASVETPLNSVLGDSSASEPGLQA--ASQPAETPSQQGIVLGP 310
Query: 561 SSPG-----TPHHPQASAGDPEPESEAEP 584
+P P QAS P P P
Sbjct: 311 LAPPPPPPLPPGPAQASVALPPPPGPPPP 339
Score = 55.1 bits (131), Expect = 5e-07
Identities = 25/42 (59%), Positives = 27/42 (64%), Gaps = 8/42 (19%)
Query: 844 PGPPPPPPPTFLGLPPPP-PPPLLDSIPPPPVPGNLLVPPPP 884
PGPPPPPP G PPPP PPPL + +PPPP PPPP
Sbjct: 334 PGPPPPPPLPSTGPPPPPPPPPLPNQVPPPP-------PPPP 368
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/63 (46%), Positives = 32/63 (50%), Gaps = 11/63 (17%)
Query: 838 LGHREAPGPPPPPP---PTFLGLP----PPPPPPLLDSIPPPPVP----GNLLVPPPPVF 886
LG P PPP PP + LP PPPPPPL + PPPP P N + PPPP
Sbjct: 308 LGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPP 367
Query: 887 NAP 889
AP
Sbjct: 368 PAP 370
Score = 46.6 bits (109), Expect = 2e-04
Identities = 60/221 (27%), Positives = 94/221 (42%), Gaps = 49/221 (22%)
Query: 391 NQVRDLREKYS-NFGN----NSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLT 445
+Q RD R+ Y NFG+ N + S+ + + + T P Q ++L +G
Sbjct: 78 HQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQ 137
Query: 446 SSF---------RQHQESLAAER-ERRRQERE----ERLQRIEREERNKFSRDYLDKREE 491
+Q Q+ L ER ER R ERE ERL+R ER ER + ++ L++ +
Sbjct: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLER-ERLERERLEQEQLERERQ 196
Query: 492 QRQ-----------AREERYKYLEQLAAE-------------EHEKELRSRSVSRGRADL 527
+R+ R+ER + E+L E E E++ R R R L
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
Query: 528 SLD----LTSPAAPACL-APLSHSPSSSDSQEALTVSASSP 563
+ ++S AAPA + PL+ S + E +AS P
Sbjct: 257 EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQP 297
Score = 45.8 bits (107), Expect = 3e-04
Identities = 19/34 (55%), Positives = 22/34 (64%), Gaps = 5/34 (14%)
Query: 844 PGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGN 877
P PPPPPPP +PPPPPPP P PP+P +
Sbjct: 347 PPPPPPPPPLPNQVPPPPPPP-----PAPPLPAS 375
Score = 33.5 bits (75), Expect = 1.5
Identities = 19/49 (38%), Positives = 24/49 (48%), Gaps = 7/49 (14%)
Query: 839 GHREAPGPPPPPPPTFLGLPP---PPPPPLLDSIPPPPVPGNLLVPPPP 884
G + A P P + L P PPPPPL PP P ++ +PPPP
Sbjct: 290 GLQAASQPAETPSQQGIVLGPLAPPPPPPL----PPGPAQASVALPPPP 334
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 56.6 bits (135), Expect = 2e-07
Identities = 45/149 (30%), Positives = 70/149 (46%), Gaps = 20/149 (13%)
Query: 449 RQHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAA 508
R+ QE L + RQER ER +R++RE + + R+ L++ E +RQ RE + EQL
Sbjct: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ----EQLER 253
Query: 509 EEHEKELRSRSVSRGRADLSLDL--------TSPAAPACLAPLSHSPSSSDSQEALTVSA 560
E+ E E R R +S A S++ +S + P A + P+ + SQ+ + +
Sbjct: 254 EQLEWE-RERRISSAAAPASVETPLNSVLGDSSASEPGLQA--ASQPAETPSQQGIVLGP 310
Query: 561 SSPG-----TPHHPQASAGDPEPESEAEP 584
+P P QAS P P P
Sbjct: 311 LAPPPPPPLPPGPAQASVALPPPPGPPPP 339
Score = 55.1 bits (131), Expect = 5e-07
Identities = 25/42 (59%), Positives = 27/42 (64%), Gaps = 8/42 (19%)
Query: 844 PGPPPPPPPTFLGLPPPP-PPPLLDSIPPPPVPGNLLVPPPP 884
PGPPPPPP G PPPP PPPL + +PPPP PPPP
Sbjct: 334 PGPPPPPPLPSTGPPPPPPPPPLPNQVPPPP-------PPPP 368
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/63 (46%), Positives = 32/63 (50%), Gaps = 11/63 (17%)
Query: 838 LGHREAPGPPPPPP---PTFLGLP----PPPPPPLLDSIPPPPVP----GNLLVPPPPVF 886
LG P PPP PP + LP PPPPPPL + PPPP P N + PPPP
Sbjct: 308 LGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPP 367
Query: 887 NAP 889
AP
Sbjct: 368 PAP 370
Score = 46.6 bits (109), Expect = 2e-04
Identities = 60/221 (27%), Positives = 94/221 (42%), Gaps = 49/221 (22%)
Query: 391 NQVRDLREKYS-NFGN----NSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLT 445
+Q RD R+ Y NFG+ N + S+ + + + T P Q ++L +G
Sbjct: 78 HQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQ 137
Query: 446 SSF---------RQHQESLAAER-ERRRQERE----ERLQRIEREERNKFSRDYLDKREE 491
+Q Q+ L ER ER R ERE ERL+R ER ER + ++ L++ +
Sbjct: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLER-ERLERERLEQEQLERERQ 196
Query: 492 QRQ-----------AREERYKYLEQLAAE-------------EHEKELRSRSVSRGRADL 527
+R+ R+ER + E+L E E E++ R R R L
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
Query: 528 SLD----LTSPAAPACL-APLSHSPSSSDSQEALTVSASSP 563
+ ++S AAPA + PL+ S + E +AS P
Sbjct: 257 EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQP 297
Score = 45.8 bits (107), Expect = 3e-04
Identities = 19/34 (55%), Positives = 22/34 (64%), Gaps = 5/34 (14%)
Query: 844 PGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGN 877
P PPPPPPP +PPPPPPP P PP+P +
Sbjct: 347 PPPPPPPPPLPNQVPPPPPPP-----PAPPLPAS 375
Score = 33.5 bits (75), Expect = 1.5
Identities = 19/49 (38%), Positives = 24/49 (48%), Gaps = 7/49 (14%)
Query: 839 GHREAPGPPPPPPPTFLGLPP---PPPPPLLDSIPPPPVPGNLLVPPPP 884
G + A P P + L P PPPPPL PP P ++ +PPPP
Sbjct: 290 GLQAASQPAETPSQQGIVLGPLAPPPPPPL----PPGPAQASVALPPPP 334
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 56.6 bits (135), Expect = 2e-07
Identities = 33/74 (44%), Positives = 38/74 (51%), Gaps = 18/74 (24%)
Query: 829 DDIDVLDVDLGHREAPGP-----PPPPPPTFLGLPPPPPPPLLDSIP---PPPVPGNLLV 880
DD+++ D D G P P PPPPPP PPPPPPP L S+P PP P LL
Sbjct: 581 DDMEISDDDRGGSPPPAPTPPQQPPPPPP-----PPPPPPPYLASLPLGYPPHQPAYLLP 635
Query: 881 -----PPPPVFNAP 889
PPPP + P
Sbjct: 636 PRPDGPPPPEYPPP 649
Score = 47.8 bits (112), Expect = 8e-05
Identities = 100/488 (20%), Positives = 167/488 (34%), Gaps = 76/488 (15%)
Query: 403 FGNNSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLTSSFRQHQESLAAERERR 462
+ +YH P + +P++ S +EARL + L ++
Sbjct: 743 YSREAYHLPMPMAAEPLPSSSVSG----EEARLPPREEAELAEGKTLPTAGTVGRVLAML 798
Query: 463 RQEREERLQR-IEREERNKFSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRSRSVS 521
QE + +QR + R+ + D+ E ++ + + ++ + A+E +KE
Sbjct: 799 VQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEK------ 852
Query: 522 RGRADLSLDLTSPAAPACLAPLSHSPSSSDSQ-EALTVSASSPGTPHHPQASAGDPEPE- 579
T P L+ + + S + EA + G P EP
Sbjct: 853 ----------TKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSE 902
Query: 580 -SEAEPEAEAGAGQVADEAGQDIASAHEGAET-EVEQALEQEPEERASLSEKERQNEGVN 637
SEA E A+E D E E + EER K R++ ++
Sbjct: 903 ISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALD 962
Query: 638 ERDNCSASSVSSSSSTLEREEKEDKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLD 697
+S SSS E +++ED+ DR + + +G+ + ++ +
Sbjct: 963 SEG--EEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKC--- 1017
Query: 698 MLYAHNRKSPDDEEKGDGEAGRTQQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLD 757
LYA + DGE T + +S ++ S+ ++S + S
Sbjct: 1018 SLYADS----------DGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSS---------- 1057
Query: 758 NRGSVKAFAEKFNSGDLGRGSISPDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRI 817
+ S + E+ L S P P VP APV+ P R+
Sbjct: 1058 SESSSEDEEEEERPAALPSASPPPREVP---VPTPAPVEV--------------PVPERV 1100
Query: 818 QDMDFTDLGEEDDIDVLDVDLGHREAPGPP--PPPPPTFLGLPPPPPPPLLDSIPPPPVP 875
T L E++ P P PP PP PP P P D P P+P
Sbjct: 1101 AGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPA----GPPAPAPRPDERPSSPIP 1156
Query: 876 GNLLVPPP 883
L+PPP
Sbjct: 1157 ---LLPPP 1161
Score = 38.1 bits (87), Expect = 0.062
Identities = 111/588 (18%), Positives = 176/588 (29%), Gaps = 123/588 (20%)
Query: 308 DLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSGGGEHRGLDRRRSRRHSV 367
D+ +++ YE+ + +G T + P+G + SG RRRS +
Sbjct: 170 DIKGQQRMKYYELIV---NGSYTPQTVPTGGKALSE-KFQGSGAATETAESRRRSSSDTA 225
Query: 368 QSIKSTLSAPT----SPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSSRPSSGSSVPTTP 423
T + T +PCSQ SF ++ +D + F S + +S S P +
Sbjct: 226 AYPAGTTAVGTPGNGTPCSQDT-SFSSSR-QDTPSSFGQFTPQSSQGTPYTSRGSTPYSQ 283
Query: 424 TSSVSPPQEA------RLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREE 477
S+ S + R E S F S A
Sbjct: 284 DSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSS 343
Query: 478 RNKFSRDYLDKREEQRQAREERYK-YLEQLAAEEHEKELRSRSVSRGR------ADLSLD 530
+ S Q ++ + Y Y E + R +R A+ + +
Sbjct: 344 LSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAE 403
Query: 531 LTSPAAPACLAPLSHSPSSSDSQEALTVSASSPGTPHHPQASAGDPEPESEAE------- 583
P+ + L P P+ D + S + P P P G P E E
Sbjct: 404 RFPPSYTSYLPPEPSRPTDQDYRPP--ASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPR 461
Query: 584 PEAEAGAGQVADEAGQDIA--SAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDN 641
P + A +G A E + + H ++ +E L+++ + + L+
Sbjct: 462 PASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLA-------------- 507
Query: 642 CSASSVSSSSSTLEREEKEDKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYA 701
S T E EE + R TG + V +G C F
Sbjct: 508 ---------SDTEEEEENSSMVLGARDTG---SEVPSGSGHGPCTPPPAPANF------- 548
Query: 702 HNRKSPDDEEKGDGEAGRTQQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGS 761
D G GE G T++ +A N Q N+ S
Sbjct: 549 -----EDVAPTGSGEPGATRESPKA-------------NGQ---------------NQAS 575
Query: 762 VKAFAEKFNSGDLGRGSISPDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMD 821
+ + D RG P A + P P P Y+ + P
Sbjct: 576 PCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPH------- 628
Query: 822 FTDLGEEDDIDVLDVDLGHREAPGPPPPPPPTFLGLPPPPPPPLLDSI 869
+ P P PPPP + PPPPPP + D +
Sbjct: 629 ---------------QPAYLLPPRPDGPPPPEYPP-PPPPPPHIYDFV 660
Score = 36.2 bits (82), Expect = 0.23
Identities = 40/147 (27%), Positives = 57/147 (38%), Gaps = 10/147 (6%)
Query: 509 EEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVSASSPGTPH- 567
EE E E + ADL+L PA L + S ++ S EA P H
Sbjct: 1241 EEEEAEPGTEVDLAVLADLALTPARRGLPA-LPAVEDSEATETSDEA---ERPRPLLSHI 1296
Query: 568 ---HPQASAGDPEPESEA--EPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPEE 622
H A A P P + A PE + ++ A E E E+ Q+ ++
Sbjct: 1297 LLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQ 1356
Query: 623 RASLSEKERQNEGVNERDNCSASSVSS 649
+ E+E + EG E + S SS SS
Sbjct: 1357 QREEGEEEGEEEGEEEEEESSDSSSSS 1383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,935,096
Number of Sequences: 37866
Number of extensions: 3475765
Number of successful extensions: 52076
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 646
Number of HSP's successfully gapped in prelim test: 1235
Number of HSP's that attempted gapping in prelim test: 22549
Number of HSP's gapped (non-prelim): 16461
length of query: 1439
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1324
effective length of database: 13,892,928
effective search space: 18394236672
effective search space used: 18394236672
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.