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Search of human proteins with 5729993
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5729993 protein tyrosine phosphatase, receptor type, E
isoform 1 precursor [Homo sapiens]
(700 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 1431 0.0
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 1295 0.0
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 941 0.0
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 941 0.0
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 939 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 566 e-161
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 566 e-161
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 558 e-159
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 556 e-158
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 556 e-158
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 556 e-158
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 556 e-158
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 552 e-157
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 552 e-157
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 552 e-157
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 549 e-156
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 438 e-123
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 438 e-123
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 438 e-123
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 426 e-119
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 423 e-118
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 423 e-118
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 421 e-117
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 421 e-117
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 420 e-117
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 378 e-105
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 377 e-104
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 377 e-104
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 375 e-104
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 370 e-102
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 1431 bits (3705), Expect = 0.0
Identities = 700/700 (100%), Positives = 700/700 (100%)
Query: 1 MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLL 60
MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLL
Sbjct: 1 MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLL 60
Query: 61 VLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHL 120
VLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHL
Sbjct: 61 VLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHL 120
Query: 121 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQ 180
EEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQ
Sbjct: 121 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQ 180
Query: 181 LDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERK 240
LDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERK
Sbjct: 181 LDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERK 240
Query: 241 EEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTS 300
EEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTS
Sbjct: 241 EEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTS 300
Query: 301 WPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK 360
WPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK
Sbjct: 301 WPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK 360
Query: 361 VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTH 420
VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTH
Sbjct: 361 VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTH 420
Query: 421 FDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTD 480
FDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTD
Sbjct: 421 FDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTD 480
Query: 481 YINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW 540
YINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW
Sbjct: 481 YINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW 540
Query: 541 PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGI 600
PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGI
Sbjct: 541 PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGI 600
Query: 601 PAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQ 660
PAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQ
Sbjct: 601 PAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQ 660
Query: 661 AVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 700
AVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
Sbjct: 661 AVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 700
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform
2 [Homo sapiens]
Length = 642
Score = 1295 bits (3350), Expect = 0.0
Identities = 630/630 (100%), Positives = 630/630 (100%)
Query: 71 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 130
FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD
Sbjct: 13 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 72
Query: 131 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 190
DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI
Sbjct: 73 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 132
Query: 191 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 250
NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD
Sbjct: 133 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 192
Query: 251 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP 310
QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP
Sbjct: 193 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP 252
Query: 311 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 370
IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI
Sbjct: 253 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 312
Query: 371 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF 430
RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF
Sbjct: 313 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF 372
Query: 431 RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY 490
RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY
Sbjct: 373 RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY 432
Query: 491 RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE 550
RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE
Sbjct: 433 RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE 492
Query: 551 ITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDL 610
ITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDL
Sbjct: 493 ITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDL 552
Query: 611 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 670
IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP
Sbjct: 553 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 612
Query: 671 HMVQTLEQYEFCYKVVQDFIDIFSDYANFK 700
HMVQTLEQYEFCYKVVQDFIDIFSDYANFK
Sbjct: 613 HMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 941 bits (2431), Expect = 0.0
Identities = 464/682 (68%), Positives = 558/682 (81%), Gaps = 14/682 (2%)
Query: 22 GNETTADSNETTTTSGPPDPGASQPLLAWLL-LPLLLLLLVLLLAAYFFRFRKQRKAVVS 80
GN +TA TT + PP P++A ++ L LL+++ +++ Y RF+K ++A
Sbjct: 123 GNSSTA---ATTPETFPPSD--ETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSH 177
Query: 81 TSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFN 140
++ ++ NG E+ E Q V LL+RSPS +KY P+PV+ LEEEI R ADD K FREEFN
Sbjct: 178 SNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFN 237
Query: 141 SLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKE 200
+LP+ IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYINAS+I+GY+E
Sbjct: 238 ALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE 297
Query: 201 KNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIR 260
KNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPDQGCWTYGNIR
Sbjct: 298 KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIR 357
Query: 261 VCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLK 318
V VED VLVDYT+RKFCIQ Q+ D K RL++Q HFTSWPDFGVPFTPIGMLKFLK
Sbjct: 358 VSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLK 416
Query: 319 KVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMV 378
KVK NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVSRIR QR QMV
Sbjct: 417 KVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMV 476
Query: 379 QTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRI 438
QTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++ GLEEEF+KLT+++I
Sbjct: 477 QTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKI 536
Query: 439 MKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIA 498
+ MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFIDGYRQKD +IA
Sbjct: 537 QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIA 596
Query: 499 TQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKND 558
+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++G+IT+E+K +
Sbjct: 597 SQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKE 656
Query: 559 TLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQ 618
E+ ++RD LVT +E + R +RQFHFHGWPE+GIP++GKGMI +IAAVQKQQ
Sbjct: 657 EECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ 711
Query: 619 QQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQ 678
QQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQRPHMVQTLEQ
Sbjct: 712 QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 679 YEFCYKVVQDFIDIFSDYANFK 700
YEFCYKVVQ++ID FSDYANFK
Sbjct: 772 YEFCYKVVQEYIDAFSDYANFK 793
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 941 bits (2431), Expect = 0.0
Identities = 464/682 (68%), Positives = 558/682 (81%), Gaps = 14/682 (2%)
Query: 22 GNETTADSNETTTTSGPPDPGASQPLLAWLL-LPLLLLLLVLLLAAYFFRFRKQRKAVVS 80
GN +TA TT + PP P++A ++ L LL+++ +++ Y RF+K ++A
Sbjct: 123 GNSSTA---ATTPETFPPSD--ETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSH 177
Query: 81 TSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFN 140
++ ++ NG E+ E Q V LL+RSPS +KY P+PV+ LEEEI R ADD K FREEFN
Sbjct: 178 SNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFN 237
Query: 141 SLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKE 200
+LP+ IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYINAS+I+GY+E
Sbjct: 238 ALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE 297
Query: 201 KNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIR 260
KNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPDQGCWTYGNIR
Sbjct: 298 KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIR 357
Query: 261 VCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLK 318
V VED VLVDYT+RKFCIQ Q+ D K RL++Q HFTSWPDFGVPFTPIGMLKFLK
Sbjct: 358 VSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLK 416
Query: 319 KVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMV 378
KVK NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVSRIR QR QMV
Sbjct: 417 KVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMV 476
Query: 379 QTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRI 438
QTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++ GLEEEF+KLT+++I
Sbjct: 477 QTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKI 536
Query: 439 MKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIA 498
+ MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFIDGYRQKD +IA
Sbjct: 537 QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIA 596
Query: 499 TQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKND 558
+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++G+IT+E+K +
Sbjct: 597 SQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKE 656
Query: 559 TLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQ 618
E+ ++RD LVT +E + R +RQFHFHGWPE+GIP++GKGMI +IAAVQKQQ
Sbjct: 657 EECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ 711
Query: 619 QQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQ 678
QQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQRPHMVQTLEQ
Sbjct: 712 QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 679 YEFCYKVVQDFIDIFSDYANFK 700
YEFCYKVVQ++ID FSDYANFK
Sbjct: 772 YEFCYKVVQEYIDAFSDYANFK 793
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 939 bits (2428), Expect = 0.0
Identities = 465/686 (67%), Positives = 560/686 (81%), Gaps = 13/686 (1%)
Query: 22 GNETTADSN-ETTTTSGPPDPGASQ---PLLAWLL-LPLLLLLLVLLLAAYFFRFRKQRK 76
GN +TA + ET SG D + P++A ++ L LL+++ +++ Y RF+K ++
Sbjct: 123 GNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQ 182
Query: 77 AVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFR 136
A ++ ++ NG E+ E Q V LL+RSPS +KY P+PV+ LEEEI R ADD K FR
Sbjct: 183 AGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFR 242
Query: 137 EEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYID 196
EEFN+LP+ IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYINAS+I+
Sbjct: 243 EEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFIN 302
Query: 197 GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTY 256
GY+EKNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPDQGCWTY
Sbjct: 303 GYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTY 362
Query: 257 GNIRVCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
GNIRV VED VLVDYT+RKFCIQ Q+ D K RL++Q HFTSWPDFGVPFTPIGML
Sbjct: 363 GNIRVSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 421
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
KFLKKVK NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVSRIR QR
Sbjct: 422 KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 481
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
QMVQTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++ GLEEEF+KLT
Sbjct: 482 CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 541
Query: 435 NVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKD 494
+++I + MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFIDGYRQKD
Sbjct: 542 SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 601
Query: 495 YFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIE 554
+IA+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++G+IT+E
Sbjct: 602 SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 661
Query: 555 IKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV 614
+K + E+ ++RD LVT +E + R +RQFHFHGWPE+GIP++GKGMI +IAAV
Sbjct: 662 LKKEEECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV 716
Query: 615 QKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQ 674
QKQQQQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQRPHMVQ
Sbjct: 717 QKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQ 776
Query: 675 TLEQYEFCYKVVQDFIDIFSDYANFK 700
TLEQYEFCYKVVQ++ID FSDYANFK
Sbjct: 777 TLEQYEFCYKVVQEYIDAFSDYANFK 802
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 566 bits (1459), Expect = e-161
Identities = 294/664 (44%), Positives = 418/664 (62%), Gaps = 14/664 (2%)
Query: 39 PDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKK---MPNGIL-EEQ 94
P +P + W+ P+L ++L++L+ F+++R S+ D++ + + +L
Sbjct: 1252 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSS 1311
Query: 95 EQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELA 154
+ + L+ G + + PIP+ L + I A+D +F +E+ S+ G Q T+E +
Sbjct: 1312 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENS 1370
Query: 155 NKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQET 214
N E N+ KNRY N++ DHSRVIL+ +DG+P SDYINA+YIDGY+++N +IA QGP ET
Sbjct: 1371 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1430
Query: 215 VNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTI 274
+ DFWRMVWEQ++AT+VM+T L+E+ KC QYWP +G T G I+V + D V L YT+
Sbjct: 1431 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1490
Query: 275 RKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVH 334
R F + G R + Q F +WPD GVP P +L FL++VK NP+ AGP+VVH
Sbjct: 1491 RTFALHKS---GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1547
Query: 335 CSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
CSAGVGRTG FIVIDAM+ M E+ VD++ V+ +R+QR MVQT+ QY FI++ALLE
Sbjct: 1548 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1607
Query: 395 YLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKK 454
G TE+ +L H+Q + +E EF+ L + + + NLP N K
Sbjct: 1608 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFK 1667
Query: 455 ARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMI 514
R++ I+PY+ RV L RG E +DYINASF+DGYRQ+ +IATQGPLA + EDFWRM+
Sbjct: 1668 NRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRML 1727
Query: 515 WEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLN 574
WE S IVMLT+++E ++KC+QYWP E S + ++ + +R+F VT
Sbjct: 1728 WEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-- 1785
Query: 575 QPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAG 633
++ Q R +RQF F WPE G+P G+G ID I V K ++Q G + PITVHCSAG
Sbjct: 1786 ---DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAG 1842
Query: 634 AGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIF 693
GRTG FI LS +LER++ EG++D+FQ VK+LR QRP MVQT +QY+ CY+ +++ F
Sbjct: 1843 VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF 1902
Query: 694 SDYA 697
YA
Sbjct: 1903 DHYA 1906
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 566 bits (1459), Expect = e-161
Identities = 294/664 (44%), Positives = 418/664 (62%), Gaps = 14/664 (2%)
Query: 39 PDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKK---MPNGIL-EEQ 94
P +P + W+ P+L ++L++L+ F+++R S+ D++ + + +L
Sbjct: 1243 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSS 1302
Query: 95 EQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELA 154
+ + L+ G + + PIP+ L + I A+D +F +E+ S+ G Q T+E +
Sbjct: 1303 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENS 1361
Query: 155 NKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQET 214
N E N+ KNRY N++ DHSRVIL+ +DG+P SDYINA+YIDGY+++N +IA QGP ET
Sbjct: 1362 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1421
Query: 215 VNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTI 274
+ DFWRMVWEQ++AT+VM+T L+E+ KC QYWP +G T G I+V + D V L YT+
Sbjct: 1422 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1481
Query: 275 RKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVH 334
R F + G R + Q F +WPD GVP P +L FL++VK NP+ AGP+VVH
Sbjct: 1482 RTFALHKS---GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1538
Query: 335 CSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
CSAGVGRTG FIVIDAM+ M E+ VD++ V+ +R+QR MVQT+ QY FI++ALLE
Sbjct: 1539 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1598
Query: 395 YLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKK 454
G TE+ +L H+Q + +E EF+ L + + + NLP N K
Sbjct: 1599 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFK 1658
Query: 455 ARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMI 514
R++ I+PY+ RV L RG E +DYINASF+DGYRQ+ +IATQGPLA + EDFWRM+
Sbjct: 1659 NRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRML 1718
Query: 515 WEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLN 574
WE S IVMLT+++E ++KC+QYWP E S + ++ + +R+F VT
Sbjct: 1719 WEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-- 1776
Query: 575 QPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAG 633
++ Q R +RQF F WPE G+P G+G ID I V K ++Q G + PITVHCSAG
Sbjct: 1777 ---DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAG 1833
Query: 634 AGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIF 693
GRTG FI LS +LER++ EG++D+FQ VK+LR QRP MVQT +QY+ CY+ +++ F
Sbjct: 1834 VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF 1893
Query: 694 SDYA 697
YA
Sbjct: 1894 DHYA 1897
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 558 bits (1438), Expect = e-159
Identities = 298/658 (45%), Positives = 414/658 (62%), Gaps = 17/658 (2%)
Query: 48 LAWLLLPLLLLLLVL--LLAAYFFRFRKQRKAVVSTSDKK-MPNG--ILEEQEQQRVML- 101
L W++ P+L ++ ++ ++A ++ + RK S S K +PN I V L
Sbjct: 853 LIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELR 912
Query: 102 -LSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENR 160
L+ G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+
Sbjct: 913 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNK 971
Query: 161 EKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWR 220
KNRY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWR
Sbjct: 972 PKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWR 1031
Query: 221 MVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280
M+WEQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 1032 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1091
Query: 281 PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVG
Sbjct: 1092 K---NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1148
Query: 341 RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400
RTG FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+T
Sbjct: 1149 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1208
Query: 401 ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460
E+ +L ++Q + T + G+E EF++L + + + NLP N K R++ I
Sbjct: 1209 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1268
Query: 461 IPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSH 520
+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S
Sbjct: 1269 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1328
Query: 521 TIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQ 580
+VMLT+++E ++KC+QYWP E S + ++ + +R+F VT +
Sbjct: 1329 IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DAR 1383
Query: 581 EEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGT 639
+ Q R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG
Sbjct: 1384 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1443
Query: 640 FIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
FI LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1444 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1501
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 556 bits (1433), Expect = e-158
Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)
Query: 48 LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103
L W++ P+L ++ ++ + ++++R A + +PN I V L L+
Sbjct: 1267 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 1325
Query: 104 RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KN
Sbjct: 1326 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 1384
Query: 164 RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223
RY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+W
Sbjct: 1385 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1444
Query: 224 EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283
EQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 1445 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1502
Query: 284 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG
Sbjct: 1503 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1561
Query: 344 TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403
FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+
Sbjct: 1562 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1621
Query: 404 VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463
+L ++Q + T + G+E EF++L + + + NLP N K R++ I+PY
Sbjct: 1622 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1681
Query: 464 DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523
+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +V
Sbjct: 1682 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1741
Query: 524 MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583
MLT+++E ++KC+QYWP E S + ++ + +R+F VT ++ Q
Sbjct: 1742 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1796
Query: 584 VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642
R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI
Sbjct: 1797 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1856
Query: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1857 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1911
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 556 bits (1433), Expect = e-158
Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)
Query: 48 LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103
L W++ P+L ++ ++ + ++++R A + +PN I V L L+
Sbjct: 1254 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 1312
Query: 104 RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KN
Sbjct: 1313 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 1371
Query: 164 RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223
RY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+W
Sbjct: 1372 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1431
Query: 224 EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283
EQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 1432 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1489
Query: 284 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG
Sbjct: 1490 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1548
Query: 344 TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403
FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+
Sbjct: 1549 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1608
Query: 404 VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463
+L ++Q + T + G+E EF++L + + + NLP N K R++ I+PY
Sbjct: 1609 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1668
Query: 464 DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523
+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +V
Sbjct: 1669 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1728
Query: 524 MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583
MLT+++E ++KC+QYWP E S + ++ + +R+F VT ++ Q
Sbjct: 1729 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1783
Query: 584 VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642
R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI
Sbjct: 1784 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1843
Query: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1844 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1898
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 556 bits (1433), Expect = e-158
Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)
Query: 48 LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103
L W++ P+L ++ ++ + ++++R A + +PN I V L L+
Sbjct: 1258 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 1316
Query: 104 RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KN
Sbjct: 1317 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 1375
Query: 164 RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223
RY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+W
Sbjct: 1376 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1435
Query: 224 EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283
EQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 1436 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1493
Query: 284 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG
Sbjct: 1494 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1552
Query: 344 TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403
FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+
Sbjct: 1553 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1612
Query: 404 VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463
+L ++Q + T + G+E EF++L + + + NLP N K R++ I+PY
Sbjct: 1613 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1672
Query: 464 DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523
+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +V
Sbjct: 1673 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1732
Query: 524 MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583
MLT+++E ++KC+QYWP E S + ++ + +R+F VT ++ Q
Sbjct: 1733 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1787
Query: 584 VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642
R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI
Sbjct: 1788 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1847
Query: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1848 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1902
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 556 bits (1433), Expect = e-158
Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)
Query: 48 LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103
L W++ P+L ++ ++ + ++++R A + +PN I V L L+
Sbjct: 856 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 914
Query: 104 RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KN
Sbjct: 915 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 973
Query: 164 RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223
RY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+W
Sbjct: 974 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1033
Query: 224 EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283
EQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 1034 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1091
Query: 284 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG
Sbjct: 1092 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1150
Query: 344 TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403
FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+
Sbjct: 1151 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1210
Query: 404 VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463
+L ++Q + T + G+E EF++L + + + NLP N K R++ I+PY
Sbjct: 1211 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1270
Query: 464 DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523
+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +V
Sbjct: 1271 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1330
Query: 524 MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583
MLT+++E ++KC+QYWP E S + ++ + +R+F VT ++ Q
Sbjct: 1331 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1385
Query: 584 VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642
R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI
Sbjct: 1386 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1445
Query: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1446 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1500
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 552 bits (1423), Expect = e-157
Identities = 297/676 (43%), Positives = 416/676 (61%), Gaps = 32/676 (4%)
Query: 39 PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86
PDP QP+ L W++ P+L ++ ++ + ++ + + S+ +
Sbjct: 844 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 900
Query: 87 ----PNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSL 142
P+ + E +R+ + G + PIP+ + E A+D + +E+ S+
Sbjct: 901 ADLAPHHPKDPVEMRRINFQT---PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI 957
Query: 143 PSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN 202
G Q T+E +N E N+ KNRY N++ DHSRVIL ++GI SDYINA+Y+DGY+ +N
Sbjct: 958 DPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1016
Query: 203 KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVC 262
+IA QGP ET DFWRMVWEQ+SATIVM+T L+E+ KC QYWP++G TYG I+V
Sbjct: 1017 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1076
Query: 263 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322
+ D + L + +R F + +G R V Q FT+WPD GVP P L FL++VKT
Sbjct: 1077 LLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1133
Query: 323 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDM 382
NP AGPIVVHCSAGVGRTG FIVIDAM+ + E+ VDV+ V+ +R+QR MVQT+
Sbjct: 1134 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1193
Query: 383 QYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKEN 442
QY+FI++ALLE G+TE+ SL ++Q + G+E EF++L N +
Sbjct: 1194 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSR 1253
Query: 443 MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP 502
+ NLP N K R++ I+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGP
Sbjct: 1254 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1313
Query: 503 LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSE 562
LA T EDFWRM+WE S +VMLT+++E ++KC+QYWP E S + ++ +
Sbjct: 1314 LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1373
Query: 563 AISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG 622
+R+F VT ++ Q R VRQF F WPE G+P G+G ID I V K ++Q G
Sbjct: 1374 QYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1428
Query: 623 -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEF 681
+ PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR QRP MVQT ++Y+F
Sbjct: 1429 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1488
Query: 682 CYKVVQDFIDIFSDYA 697
CY+ +++ F YA
Sbjct: 1489 CYQAALEYLGSFDHYA 1504
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 552 bits (1423), Expect = e-157
Identities = 297/676 (43%), Positives = 416/676 (61%), Gaps = 32/676 (4%)
Query: 39 PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86
PDP QP+ L W++ P+L ++ ++ + ++ + + S+ +
Sbjct: 1249 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 1305
Query: 87 ----PNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSL 142
P+ + E +R+ + G + PIP+ + E A+D + +E+ S+
Sbjct: 1306 ADLAPHHPKDPVEMRRINFQT---PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI 1362
Query: 143 PSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN 202
G Q T+E +N E N+ KNRY N++ DHSRVIL ++GI SDYINA+Y+DGY+ +N
Sbjct: 1363 DPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1421
Query: 203 KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVC 262
+IA QGP ET DFWRMVWEQ+SATIVM+T L+E+ KC QYWP++G TYG I+V
Sbjct: 1422 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1481
Query: 263 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322
+ D + L + +R F + +G R V Q FT+WPD GVP P L FL++VKT
Sbjct: 1482 LLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1538
Query: 323 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDM 382
NP AGPIVVHCSAGVGRTG FIVIDAM+ + E+ VDV+ V+ +R+QR MVQT+
Sbjct: 1539 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1598
Query: 383 QYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKEN 442
QY+FI++ALLE G+TE+ SL ++Q + G+E EF++L N +
Sbjct: 1599 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSR 1658
Query: 443 MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP 502
+ NLP N K R++ I+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGP
Sbjct: 1659 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1718
Query: 503 LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSE 562
LA T EDFWRM+WE S +VMLT+++E ++KC+QYWP E S + ++ +
Sbjct: 1719 LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1778
Query: 563 AISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG 622
+R+F VT ++ Q R VRQF F WPE G+P G+G ID I V K ++Q G
Sbjct: 1779 QYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1833
Query: 623 -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEF 681
+ PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR QRP MVQT ++Y+F
Sbjct: 1834 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1893
Query: 682 CYKVVQDFIDIFSDYA 697
CY+ +++ F YA
Sbjct: 1894 CYQAALEYLGSFDHYA 1909
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 552 bits (1423), Expect = e-157
Identities = 297/676 (43%), Positives = 416/676 (61%), Gaps = 32/676 (4%)
Query: 39 PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86
PDP QP+ L W++ P+L ++ ++ + ++ + + S+ +
Sbjct: 840 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 896
Query: 87 ----PNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSL 142
P+ + E +R+ + G + PIP+ + E A+D + +E+ S+
Sbjct: 897 ADLAPHHPKDPVEMRRINFQT---PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI 953
Query: 143 PSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN 202
G Q T+E +N E N+ KNRY N++ DHSRVIL ++GI SDYINA+Y+DGY+ +N
Sbjct: 954 DPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1012
Query: 203 KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVC 262
+IA QGP ET DFWRMVWEQ+SATIVM+T L+E+ KC QYWP++G TYG I+V
Sbjct: 1013 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1072
Query: 263 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322
+ D + L + +R F + +G R V Q FT+WPD GVP P L FL++VKT
Sbjct: 1073 LLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1129
Query: 323 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDM 382
NP AGPIVVHCSAGVGRTG FIVIDAM+ + E+ VDV+ V+ +R+QR MVQT+
Sbjct: 1130 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1189
Query: 383 QYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKEN 442
QY+FI++ALLE G+TE+ SL ++Q + G+E EF++L N +
Sbjct: 1190 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSR 1249
Query: 443 MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP 502
+ NLP N K R++ I+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGP
Sbjct: 1250 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1309
Query: 503 LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSE 562
LA T EDFWRM+WE S +VMLT+++E ++KC+QYWP E S + ++ +
Sbjct: 1310 LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1369
Query: 563 AISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG 622
+R+F VT ++ Q R VRQF F WPE G+P G+G ID I V K ++Q G
Sbjct: 1370 QYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1424
Query: 623 -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEF 681
+ PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR QRP MVQT ++Y+F
Sbjct: 1425 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1484
Query: 682 CYKVVQDFIDIFSDYA 697
CY+ +++ F YA
Sbjct: 1485 CYQAALEYLGSFDHYA 1500
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 549 bits (1415), Expect = e-156
Identities = 301/689 (43%), Positives = 420/689 (60%), Gaps = 42/689 (6%)
Query: 39 PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86
PDP QP+ L W++ P+L ++ ++ + ++ + + S+ +
Sbjct: 1271 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 1327
Query: 87 ----PNGILEEQEQQRVMLLS-----RSP-SGPKKYF-------PIPVEHLEEEIRIRSA 129
P+ + E +R+ + RSP P +F PIP+ + E A
Sbjct: 1328 ADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKA 1387
Query: 130 DDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDY 189
+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DHSRVIL ++GI SDY
Sbjct: 1388 NDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1446
Query: 190 INASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP 249
INA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+T L+E+ KC QYWP
Sbjct: 1447 INANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP 1506
Query: 250 DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFT 309
++G TYG I+V + D + L + +R F + +G R V Q FT+WPD GVP
Sbjct: 1507 NRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEY 1563
Query: 310 PIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSR 369
P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+ + E+ VDV+ V+
Sbjct: 1564 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1623
Query: 370 IRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEE 429
+R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q + G+E E
Sbjct: 1624 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELE 1683
Query: 430 FRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDG 489
F++L N + + NLP N K R++ I+PY+ RV L RG E +DYINASFIDG
Sbjct: 1684 FKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDG 1743
Query: 490 YRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHG 549
YRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E ++KC+QYWP E S +
Sbjct: 1744 YRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQ 1803
Query: 550 EITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMID 609
++ + +R+F VT ++ Q R VRQF F WPE G+P G+G ID
Sbjct: 1804 YFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFID 1858
Query: 610 LIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQ 668
I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR Q
Sbjct: 1859 FIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQ 1918
Query: 669 RPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
RP MVQT ++Y+FCY+ +++ F YA
Sbjct: 1919 RPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 438 bits (1126), Expect = e-123
Identities = 257/674 (38%), Positives = 383/674 (56%), Gaps = 55/674 (8%)
Query: 44 SQPLLAWLLLPLLLLLLVLLLAAY-FFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLL 102
S+ L+A+L +++ + LL+ Y + K+R + + ++E +++++M +
Sbjct: 526 SKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQE-----LVERDDEKQLMNV 580
Query: 103 SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREK 162
PI + L E + + AD+ + F EF S+P + + A K N+ K
Sbjct: 581 E----------PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNK 630
Query: 163 NRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMV 222
NRY +ILP D++RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+
Sbjct: 631 NRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI 690
Query: 223 WEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280
WEQK+ IVM+T +E KC +YWP ++G +G++ V + DY I+K I
Sbjct: 691 WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV 750
Query: 281 PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340
+ R V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVG
Sbjct: 751 NKKEKA--TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG 808
Query: 341 RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400
RTGT+I IDAM+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+T
Sbjct: 809 RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGET 868
Query: 401 ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460
E+++S L +L M + LE EF++L + R + GN N K R +
Sbjct: 869 EVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNV 927
Query: 461 IPYDFNRVILSMK-------------------RGQEYTDYINASFIDGYRQKDYFIATQG 501
IPYD+NRV L + +E + YINASFI Y + + IA QG
Sbjct: 928 IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 987
Query: 502 PLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLS 561
PL T+ DFW+MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S
Sbjct: 988 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKS 1046
Query: 562 EAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QK 616
++R F + + + + R V Q+ + W +PAE K +I +I V QK
Sbjct: 1047 STYTLRVF-----ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQK 1101
Query: 617 QQQQTGNH----PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHM 672
+ H P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP M
Sbjct: 1102 NSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM 1161
Query: 673 VQTLEQYEFCYKVV 686
V T EQY+F Y V+
Sbjct: 1162 VSTFEQYQFLYDVI 1175
Score = 173 bits (439), Expect = 4e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 429 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 488
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 606 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 664
Query: 489 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 546
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 665 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 724
Query: 547 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 725 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 779
Query: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 780 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 838
Query: 666 RLQRPHMVQTLEQYEFCYKVVQDF 689
R QR MVQ QY ++ + ++
Sbjct: 839 RRQRCLMVQVEAQYILIHQALVEY 862
Score = 158 bits (399), Expect = 2e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 138 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 188
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 897 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
Query: 189 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 238
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 957 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
Query: 239 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 298
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 1072
Query: 299 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 348
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
Query: 349 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 395
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 438 bits (1126), Expect = e-123
Identities = 257/674 (38%), Positives = 383/674 (56%), Gaps = 55/674 (8%)
Query: 44 SQPLLAWLLLPLLLLLLVLLLAAY-FFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLL 102
S+ L+A+L +++ + LL+ Y + K+R + + ++E +++++M +
Sbjct: 574 SKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQE-----LVERDDEKQLMNV 628
Query: 103 SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREK 162
PI + L E + + AD+ + F EF S+P + + A K N+ K
Sbjct: 629 E----------PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNK 678
Query: 163 NRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMV 222
NRY +ILP D++RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+
Sbjct: 679 NRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI 738
Query: 223 WEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280
WEQK+ IVM+T +E KC +YWP ++G +G++ V + DY I+K I
Sbjct: 739 WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV 798
Query: 281 PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340
+ R V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVG
Sbjct: 799 NKKEKA--TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG 856
Query: 341 RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400
RTGT+I IDAM+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+T
Sbjct: 857 RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGET 916
Query: 401 ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460
E+++S L +L M + LE EF++L + R + GN N K R +
Sbjct: 917 EVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNV 975
Query: 461 IPYDFNRVILSMK-------------------RGQEYTDYINASFIDGYRQKDYFIATQG 501
IPYD+NRV L + +E + YINASFI Y + + IA QG
Sbjct: 976 IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 1035
Query: 502 PLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLS 561
PL T+ DFW+MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S
Sbjct: 1036 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKS 1094
Query: 562 EAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QK 616
++R F + + + + R V Q+ + W +PAE K +I +I V QK
Sbjct: 1095 STYTLRVF-----ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQK 1149
Query: 617 QQQQTGNH----PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHM 672
+ H P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP M
Sbjct: 1150 NSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM 1209
Query: 673 VQTLEQYEFCYKVV 686
V T EQY+F Y V+
Sbjct: 1210 VSTFEQYQFLYDVI 1223
Score = 173 bits (439), Expect = 4e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 429 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 488
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 654 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 712
Query: 489 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 546
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 713 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 772
Query: 547 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 773 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 827
Query: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 828 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 886
Query: 666 RLQRPHMVQTLEQYEFCYKVVQDF 689
R QR MVQ QY ++ + ++
Sbjct: 887 RRQRCLMVQVEAQYILIHQALVEY 910
Score = 158 bits (399), Expect = 2e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 138 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 188
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 945 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 1004
Query: 189 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 238
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 1005 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1064
Query: 239 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 298
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 1065 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 1120
Query: 299 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 348
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1121 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1180
Query: 349 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 395
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 1181 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1227
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 438 bits (1126), Expect = e-123
Identities = 257/674 (38%), Positives = 383/674 (56%), Gaps = 55/674 (8%)
Query: 44 SQPLLAWLLLPLLLLLLVLLLAAY-FFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLL 102
S+ L+A+L +++ + LL+ Y + K+R + + ++E +++++M +
Sbjct: 413 SKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQE-----LVERDDEKQLMNV 467
Query: 103 SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREK 162
PI + L E + + AD+ + F EF S+P + + A K N+ K
Sbjct: 468 E----------PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNK 517
Query: 163 NRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMV 222
NRY +ILP D++RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+
Sbjct: 518 NRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI 577
Query: 223 WEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280
WEQK+ IVM+T +E KC +YWP ++G +G++ V + DY I+K I
Sbjct: 578 WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV 637
Query: 281 PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340
+ R V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVG
Sbjct: 638 NKKEKA--TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG 695
Query: 341 RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400
RTGT+I IDAM+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+T
Sbjct: 696 RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGET 755
Query: 401 ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460
E+++S L +L M + LE EF++L + R + GN N K R +
Sbjct: 756 EVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNV 814
Query: 461 IPYDFNRVILSMK-------------------RGQEYTDYINASFIDGYRQKDYFIATQG 501
IPYD+NRV L + +E + YINASFI Y + + IA QG
Sbjct: 815 IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 874
Query: 502 PLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLS 561
PL T+ DFW+MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S
Sbjct: 875 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKS 933
Query: 562 EAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QK 616
++R F + + + + R V Q+ + W +PAE K +I +I V QK
Sbjct: 934 STYTLRVF-----ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQK 988
Query: 617 QQQQTGNH----PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHM 672
+ H P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP M
Sbjct: 989 NSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM 1048
Query: 673 VQTLEQYEFCYKVV 686
V T EQY+F Y V+
Sbjct: 1049 VSTFEQYQFLYDVI 1062
Score = 173 bits (439), Expect = 4e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 429 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 488
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 493 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 551
Query: 489 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 546
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 552 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 611
Query: 547 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 612 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 666
Query: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 667 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 725
Query: 666 RLQRPHMVQTLEQYEFCYKVVQDF 689
R QR MVQ QY ++ + ++
Sbjct: 726 RRQRCLMVQVEAQYILIHQALVEY 749
Score = 158 bits (399), Expect = 2e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 138 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 188
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
Query: 189 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 238
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
Query: 239 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 298
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 959
Query: 299 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 348
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
Query: 349 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 395
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 426 bits (1096), Expect = e-119
Identities = 238/583 (40%), Positives = 346/583 (59%), Gaps = 18/583 (3%)
Query: 115 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 174
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 175 RVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT 234
RVIL ++ P SDYINA+YIDGY+ + +IA QGP ETV DFWRM+W+++SA IVM+T
Sbjct: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
Query: 235 NLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVS 294
NL E KC++YWPD YG+ +V + L +Y +R F ++ + G R V
Sbjct: 987 NLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYNEIREVK 1042
Query: 295 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAM 354
Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVID M+ M
Sbjct: 1043 QFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM 1102
Query: 355 MHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTM 414
E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V + M
Sbjct: 1103 AEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDM 1162
Query: 415 HGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSM 472
+ + L++EF+ L +V R+ E+ LP N K R + ++P D L
Sbjct: 1163 IRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLIT 1222
Query: 473 KRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQERE 532
G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML EV +
Sbjct: 1223 IDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ 1281
Query: 533 QDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVRVVRQFH 591
C QYWP EG + +G I +E + ++ + R F + L +PQ E +V+QF
Sbjct: 1282 --GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYLMVQQFQ 1335
Query: 592 FHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIALSNILE 648
+ GW +P + + LI V+K Q+ + G +HC G GR+G F A+ ++E
Sbjct: 1336 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1395
Query: 649 RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 691
VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 1396 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 423 bits (1087), Expect = e-118
Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F+EE+ S G ++ A K+ENR KNRY NI+ DHSRV L ++G SDYIN +Y
Sbjct: 900 FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 958
Query: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
IDGY N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E KC +YWPD
Sbjct: 959 IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1017
Query: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
Y +I+V + + +L +Y IR F ++ + G R + Q HFT WPD GVP+ G+L
Sbjct: 1018 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1074
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
F+++VK+ +P AGP+VVHCSAG GRTG FIVID M+ M E VD++ V +R++R
Sbjct: 1075 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1134
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
MVQT+ QY FI+ A+LE L GDT + S + M+ + ++EEFR L
Sbjct: 1135 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1194
Query: 435 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
V + E+ LP N +K R + I+P D L G E ++YINA+ +D Y+Q
Sbjct: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
Query: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552
FI TQ PL +TV+DFWR++ ++ ++VML +V + C QYWP G HG I
Sbjct: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1311
Query: 553 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611
+E + L E I R F + AR ++ R+V+QF F GWP P + + LI
Sbjct: 1312 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1368
Query: 612 AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669
V K Q++ G VHC G GR+GTF A+S + E ++ + +DVF AVK+LR +
Sbjct: 1369 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1428
Query: 670 PHMVQTLEQYEFCYKVVQDFID 691
P+MV L+QY+FCY+V ++++
Sbjct: 1429 PNMVDLLDQYKFCYEVALEYLN 1450
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 423 bits (1087), Expect = e-118
Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F+EE+ S G ++ A K+ENR KNRY NI+ DHSRV L ++G SDYIN +Y
Sbjct: 913 FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 971
Query: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
IDGY N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E KC +YWPD
Sbjct: 972 IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1030
Query: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
Y +I+V + + +L +Y IR F ++ + G R + Q HFT WPD GVP+ G+L
Sbjct: 1031 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1087
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
F+++VK+ +P AGP+VVHCSAG GRTG FIVID M+ M E VD++ V +R++R
Sbjct: 1088 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1147
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
MVQT+ QY FI+ A+LE L GDT + S + M+ + ++EEFR L
Sbjct: 1148 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1207
Query: 435 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
V + E+ LP N +K R + I+P D L G E ++YINA+ +D Y+Q
Sbjct: 1208 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1266
Query: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552
FI TQ PL +TV+DFWR++ ++ ++VML +V + C QYWP G HG I
Sbjct: 1267 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1324
Query: 553 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611
+E + L E I R F + AR ++ R+V+QF F GWP P + + LI
Sbjct: 1325 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1381
Query: 612 AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669
V K Q++ G VHC G GR+GTF A+S + E ++ + +DVF AVK+LR +
Sbjct: 1382 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1441
Query: 670 PHMVQTLEQYEFCYKVVQDFID 691
P+MV L+QY+FCY+V ++++
Sbjct: 1442 PNMVDLLDQYKFCYEVALEYLN 1463
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 421 bits (1082), Expect = e-117
Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F+EE+ +LP G +++ A ++ENR KNRY NI+ DHSRV L LDG P SDYINA+Y
Sbjct: 889 FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 947
Query: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
IDGY +IA QGP QETV DFWRM+W++ SA+IVM+TNL E KC +YWPD
Sbjct: 948 IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1006
Query: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
YG+I+V + + L +Y IR F +Q + G R + HFTSWPD GVP G+L
Sbjct: 1007 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1063
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
F+++VK LNP AGPIVVHCSAG GRTG FI ID M+ M E VD+F V +R QR
Sbjct: 1064 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1123
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
+VQT+ QY F++ A+LE L G+T + V + + +++EF+ L
Sbjct: 1124 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1183
Query: 435 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
V R+ E+ G LP N K R + ++P D L G E ++YINA+ +D ++Q
Sbjct: 1184 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1242
Query: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552
F+ TQ PL +TV DFWR+++++ ++VML E+ + C QYWP + S +G I
Sbjct: 1243 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1300
Query: 553 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611
+E + + E I R F + AR ++ R+V+ + GWP P + ++ ++
Sbjct: 1301 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1357
Query: 612 AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669
++K Q+Q VHC G GR+GTF A+ ++ E ++ + ++DVF VK+LR +
Sbjct: 1358 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1417
Query: 670 PHMVQTLEQYEFCYKVVQDFIDIF 693
+MV+TLEQY+F Y+V +++ F
Sbjct: 1418 SNMVETLEQYKFVYEVALEYLSSF 1441
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 421 bits (1082), Expect = e-117
Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F+EE+ +LP G +++ A ++ENR KNRY NI+ DHSRV L LDG P SDYINA+Y
Sbjct: 908 FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 966
Query: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
IDGY +IA QGP QETV DFWRM+W++ SA+IVM+TNL E KC +YWPD
Sbjct: 967 IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1025
Query: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
YG+I+V + + L +Y IR F +Q + G R + HFTSWPD GVP G+L
Sbjct: 1026 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1082
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
F+++VK LNP AGPIVVHCSAG GRTG FI ID M+ M E VD+F V +R QR
Sbjct: 1083 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1142
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
+VQT+ QY F++ A+LE L G+T + V + + +++EF+ L
Sbjct: 1143 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1202
Query: 435 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
V R+ E+ G LP N K R + ++P D L G E ++YINA+ +D ++Q
Sbjct: 1203 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1261
Query: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552
F+ TQ PL +TV DFWR+++++ ++VML E+ + C QYWP + S +G I
Sbjct: 1262 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1319
Query: 553 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611
+E + + E I R F + AR ++ R+V+ + GWP P + ++ ++
Sbjct: 1320 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1376
Query: 612 AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669
++K Q+Q VHC G GR+GTF A+ ++ E ++ + ++DVF VK+LR +
Sbjct: 1377 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1436
Query: 670 PHMVQTLEQYEFCYKVVQDFIDIF 693
+MV+TLEQY+F Y+V +++ F
Sbjct: 1437 SNMVETLEQYKFVYEVALEYLSSF 1460
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 420 bits (1079), Expect = e-117
Identities = 238/589 (40%), Positives = 346/589 (58%), Gaps = 24/589 (4%)
Query: 115 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 174
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 175 RVILSQLDGIPCSDYINASYID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSA 228
RVIL ++ P SDYINA+YID GY+ + +IA QGP ETV DFWRM+W+++SA
Sbjct: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
Query: 229 TIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCK 288
IVM+TNL E KC++YWPD YG+ +V + L +Y +R F ++ + G
Sbjct: 987 CIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYN 1042
Query: 289 APRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVI 348
R V Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVI
Sbjct: 1043 EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVI 1102
Query: 349 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLE 408
D M+ M E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V +
Sbjct: 1103 DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK 1162
Query: 409 KHLQTMHGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFN 466
M + + L++EF+ L +V R+ E+ LP N K R + ++P D
Sbjct: 1163 AAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRC 1222
Query: 467 RVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT 526
L G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML
Sbjct: 1223 LPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN 1281
Query: 527 EVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVR 585
EV + C QYWP EG + +G I +E + ++ + R F + L +PQ E
Sbjct: 1282 EVDLSQ--GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYL 1335
Query: 586 VVRQFHFHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIA 642
+V+QF + GW +P + + LI V+K Q+ + G +HC G GR+G F A
Sbjct: 1336 MVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCA 1395
Query: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 691
+ ++E VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 1396 IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 378 bits (971), Expect = e-105
Identities = 232/625 (37%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 91 LEEQEQQRVMLLSRSPSGP--KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGH-- 146
LE+ RV+ +P P IP++H + + A F EEF +L +
Sbjct: 1673 LEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASS--GFTEEFETLKEFYQE 1730
Query: 147 IQG-------TFELANKEENREKNRYPNILPNDHSRVILSQL---DGIPCSDYINASYID 196
+Q T + +N +N+ KNRY NI+ DHSRV L+QL DG +DYINA+Y+D
Sbjct: 1731 VQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDG-KLTDYINANYVD 1789
Query: 197 GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTY 256
GY +IAAQGP + T DFWRM+WE IVM+TNL E+ KC QYWP G Y
Sbjct: 1790 GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEY 1849
Query: 257 GNIRVCVEDCVVLVDYTIRKFC-----IQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPI 311
GN V + VL YT+R F I+ G + R+V+Q H+T WPD GVP +
Sbjct: 1850 GNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSL 1909
Query: 312 GMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIR 371
+L F++K GP+VVHCSAGVGRTGT+IV+D+M+ + E V++F F+ IR
Sbjct: 1910 PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIR 1969
Query: 372 NQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFR 431
+QR +VQT+ QY FI+ L+E L +TE+ S + ++ + K LE++F+
Sbjct: 1970 SQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQ 2028
Query: 432 KLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYR 491
L+ I + + N +K R IIP + +RV +S G E TDYINAS+I GY
Sbjct: 2029 LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYY 2087
Query: 492 QKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE- 550
Q + FI TQ PL HT++DFWRMIW+ + +VM+ + Q +D+ + YWP + + E
Sbjct: 2088 QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCES 2146
Query: 551 --ITI---EIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605
+T+ E K + E + I+DF++ +A Q++ V VR F WP P
Sbjct: 2147 FKVTLMAEEHKCLSNEEKLIIQDFIL-----EATQDDYVLEVRHFQCPKWPNPDSPI--S 2199
Query: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665
+LI+ + K++ + P+ VH G GTF AL+ ++ +++ E +DV+Q K +
Sbjct: 2200 KTFELISVI-KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMI 2258
Query: 666 RLQRPHMVQTLEQYEFCYKVVQDFI 690
L RP + +EQY+F YKV+ +
Sbjct: 2259 NLMRPGVFADIEQYQFLYKVILSLV 2283
Score = 125 bits (314), Expect = 1e-28
Identities = 86/285 (30%), Positives = 142/285 (49%), Gaps = 16/285 (5%)
Query: 134 QFREEFNSLPSGHIQGT-FELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINA 192
+ ++F L +IQ + + A K+ NREKNR +I+P + SRV +S L G +DYINA
Sbjct: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
Query: 193 SYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ- 251
SYI GY + N+FI Q P T+ DFWRM+W+ + +VM+ + + E++ YWP++
Sbjct: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKD 2139
Query: 252 ---GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFT--SWPDFGV 306
C ++ + + E+ L + K IQ + + + ++ HF WP+
Sbjct: 2140 EPINCESF-KVTLMAEEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPN--- 2193
Query: 307 PFTPIGM-LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFE 365
P +PI + + +K GP++VH G GTF + +M + E VDV++
Sbjct: 2194 PDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQ 2253
Query: 366 FVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKH 410
I RP + QY F+Y+ +L E +SL+ +
Sbjct: 2254 VAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 377 bits (967), Expect = e-104
Identities = 212/561 (37%), Positives = 313/561 (55%), Gaps = 17/561 (3%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 884 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 938
Query: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
IDGY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YWP+
Sbjct: 939 IDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD- 997
Query: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+ G+L
Sbjct: 998 TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPYHATGLL 1054
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V + ++R
Sbjct: 1055 AFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRR 1114
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
M+QT+ QY FI+ A+LE L G+T + VS + + M + L EEF+ L
Sbjct: 1115 VNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLN 1174
Query: 435 NVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
+V + E LP N K R + ++P D L G + +YINA+ D Y +
Sbjct: 1175 SVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTR 1233
Query: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGSVTHGEI 551
FI T PL T DFWR+++++ +IVML ++ Q C QYWP G +G +
Sbjct: 1234 SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLM 1293
Query: 552 TIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDL 610
+E + T E + R F V Q +R +E +VR F F W P K + L
Sbjct: 1294 EVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1350
Query: 611 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 670
+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+LR +P
Sbjct: 1351 LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKP 1410
Query: 671 HMVQTLEQYEFCYKVVQDFID 691
+MV+T++QY FCY V ++++
Sbjct: 1411 NMVETMDQYHFCYDVALEYLE 1431
Score = 131 bits (329), Expect = 2e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 121 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 177
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 1152 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1211
Query: 178 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 237
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 1212 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1270
Query: 238 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 294
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 1271 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1330
Query: 295 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 350
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 1331 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1385
Query: 351 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 1386 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1429
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 377 bits (967), Expect = e-104
Identities = 212/561 (37%), Positives = 313/561 (55%), Gaps = 17/561 (3%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 894 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 948
Query: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
IDGY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YWP+
Sbjct: 949 IDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD- 1007
Query: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+ G+L
Sbjct: 1008 TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPYHATGLL 1064
Query: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V + ++R
Sbjct: 1065 AFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRR 1124
Query: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
M+QT+ QY FI+ A+LE L G+T + VS + + M + L EEF+ L
Sbjct: 1125 VNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLN 1184
Query: 435 NVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
+V + E LP N K R + ++P D L G + +YINA+ D Y +
Sbjct: 1185 SVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTR 1243
Query: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGSVTHGEI 551
FI T PL T DFWR+++++ +IVML ++ Q C QYWP G +G +
Sbjct: 1244 SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLM 1303
Query: 552 TIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDL 610
+E + T E + R F V Q +R +E +VR F F W P K + L
Sbjct: 1304 EVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1360
Query: 611 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 670
+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+LR +P
Sbjct: 1361 LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKP 1420
Query: 671 HMVQTLEQYEFCYKVVQDFID 691
+MV+T++QY FCY V ++++
Sbjct: 1421 NMVETMDQYHFCYDVALEYLE 1441
Score = 131 bits (329), Expect = 2e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 121 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 177
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 1162 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1221
Query: 178 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 237
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 1222 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1280
Query: 238 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 294
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 1281 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1340
Query: 295 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 350
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 1341 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
Query: 351 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1439
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 375 bits (963), Expect = e-104
Identities = 250/719 (34%), Positives = 369/719 (51%), Gaps = 59/719 (8%)
Query: 21 RGNETTADSNETTT------TSGP---PDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRF 71
RG+ + DS T TSG P PG + ++ +++ L + ++LL A +
Sbjct: 703 RGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYW 762
Query: 72 R----------KQRKAVVSTSDKKMPNG----------ILEEQEQQRVMLLSRSP--SGP 109
R +R V +S ++ G +E+ RV+ P P
Sbjct: 763 RGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIP 822
Query: 110 KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLP--SGHIQGTFELANKEENREKNRYPN 167
IPV+ + I +++ F E+F + + + T E +N EN+ KNRY N
Sbjct: 823 DDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYIN 882
Query: 168 ILPNDHSRVILSQLDGIPC--SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQ 225
IL DHSRV L L G SDYINA+Y+DGY + +IA QGP + T DFWRM+WEQ
Sbjct: 883 ILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ 942
Query: 226 KSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCI------ 279
+ IVM+TNL E+ KC QYWP + YGNI V ++ + YT+R+F I
Sbjct: 943 NTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVK 1002
Query: 280 --QPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSA 337
Q P G + R+V Q H+T WPD GVP + +L F+++ GP++VHCSA
Sbjct: 1003 KGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSA 1062
Query: 338 GVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLY 397
GVGRTGT+IVID+M+ + + V+V F+ IR QR +VQT+ QY FI+ ALLE L
Sbjct: 1063 GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG 1122
Query: 398 GDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARV 457
+TE+ + L ++ ++ K LE++F+ +T + N +K R
Sbjct: 1123 KETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRN 1181
Query: 458 IQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEW 517
++P + RV L+ G + TDYINAS+I GY + + FI TQ PL HT +DFWRMIW+
Sbjct: 1182 SSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDH 1241
Query: 518 KSHTIVMLTEVQEREQDKCYQYWPT-EGSVTHGEITIE-IKNDTL----SEAISIRDFLV 571
+ IVML + Q +D+ + YWP+ E S+ T+ I D L E I I DF++
Sbjct: 1242 NAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
Query: 572 TLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCS 631
+A Q++ V VR F WP P +LI + K++ T + P VH
Sbjct: 1301 -----EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVI-KEEALTRDGPTIVHDE 1352
Query: 632 AGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI 690
GA G AL+ + ++++ E +DVFQ K + L RP + +EQY+F YK + +
Sbjct: 1353 YGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV 1411
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 370 bits (950), Expect = e-102
Identities = 212/567 (37%), Positives = 313/567 (55%), Gaps = 23/567 (4%)
Query: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 884 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 938
Query: 195 ID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW 248
ID GY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YW
Sbjct: 939 IDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW 998
Query: 249 PDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPF 308
P+ TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+
Sbjct: 999 PEDSD-TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPY 1054
Query: 309 TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 368
G+L F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V
Sbjct: 1055 HATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVK 1114
Query: 369 RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 428
+ ++R M+QT+ QY FI+ A+LE L G+T + VS + + M + L E
Sbjct: 1115 TLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLRE 1174
Query: 429 EFRKLTNVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 486
EF+ L +V + E LP N K R + ++P D L G + +YINA+
Sbjct: 1175 EFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAAL 1233
Query: 487 IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGS 545
D Y + FI T PL T DFWR+++++ +IVML ++ Q C QYWP G
Sbjct: 1234 TDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGR 1293
Query: 546 VTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEG 604
+G + +E + T E + R F V Q +R +E +VR F F W P
Sbjct: 1294 QQYGLMEVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSK 1350
Query: 605 KGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKS 664
K + L+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+
Sbjct: 1351 KAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKT 1410
Query: 665 LRLQRPHMVQTLEQYEFCYKVVQDFID 691
LR +P+MV+T++QY FCY V ++++
Sbjct: 1411 LRNYKPNMVETMDQYHFCYDVALEYLE 1437
Score = 131 bits (329), Expect = 2e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 121 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 177
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 1158 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1217
Query: 178 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 237
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 1218 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
Query: 238 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 294
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
Query: 295 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 350
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 1337 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1391
Query: 351 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 1392 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1435
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,994,396
Number of Sequences: 37866
Number of extensions: 1244396
Number of successful extensions: 4707
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 3720
Number of HSP's gapped (non-prelim): 302
length of query: 700
length of database: 18,247,518
effective HSP length: 109
effective length of query: 591
effective length of database: 14,120,124
effective search space: 8344993284
effective search space used: 8344993284
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.