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Search of human proteins with 5729972
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
(779 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 1580 0.0
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 1554 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 368 e-101
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 360 4e-99
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 342 1e-93
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 342 1e-93
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 342 1e-93
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 341 1e-93
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 329 5e-90
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 329 5e-90
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 329 5e-90
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 319 7e-87
gi|170650674 phosphodiesterase 6A [Homo sapiens] 238 1e-62
gi|157364939 phosphodiesterase 6C [Homo sapiens] 238 2e-62
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 231 3e-60
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 231 3e-60
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 223 4e-58
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 120 4e-27
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 120 4e-27
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 120 4e-27
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 119 8e-27
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 119 8e-27
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 119 8e-27
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 119 8e-27
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 119 8e-27
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 119 8e-27
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 119 8e-27
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 119 8e-27
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 119 8e-27
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 119 8e-27
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 1580 bits (4090), Expect = 0.0
Identities = 779/779 (100%), Positives = 779/779 (100%)
Query: 1 MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP 60
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP
Sbjct: 1 MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP 60
Query: 61 KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC 120
KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC
Sbjct: 61 KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC 120
Query: 121 NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE 180
NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE
Sbjct: 121 NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE 180
Query: 181 SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC 240
SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC
Sbjct: 181 SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC 240
Query: 241 RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY 300
RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY
Sbjct: 241 RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY 300
Query: 301 SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT 360
SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT
Sbjct: 301 SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT 360
Query: 361 GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR 420
GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR
Sbjct: 361 GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR 420
Query: 421 IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF 480
IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF
Sbjct: 421 IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF 480
Query: 481 VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD 540
VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD
Sbjct: 481 VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD 540
Query: 541 LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI 600
LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI
Sbjct: 541 LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI 600
Query: 601 FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM 660
FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM
Sbjct: 601 FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM 660
Query: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 1554 bits (4024), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 14 LTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQG 73
LTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQG
Sbjct: 24 LTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQG 83
Query: 74 VVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIK 133
VVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIK
Sbjct: 84 VVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIK 143
Query: 134 EGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPI 193
EGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPI
Sbjct: 144 EGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPI 203
Query: 194 VTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFL 253
VTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFL
Sbjct: 204 VTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFL 263
Query: 254 LDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGK 313
LDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGK
Sbjct: 264 LDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGK 323
Query: 314 PVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV 373
PVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV
Sbjct: 324 PVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV 383
Query: 374 SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTME 433
SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTME
Sbjct: 384 SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTME 443
Query: 434 KLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCF 493
KLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCF
Sbjct: 444 KLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCF 503
Query: 494 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCH 553
ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCH
Sbjct: 504 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCH 563
Query: 554 DLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613
DLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL
Sbjct: 564 DLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623
Query: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673
EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP
Sbjct: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683
Query: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733
VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ
Sbjct: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743
Query: 734 ILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
ILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Sbjct: 744 ILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 789
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 368 bits (944), Expect = e-101
Identities = 215/650 (33%), Positives = 356/650 (54%), Gaps = 19/650 (2%)
Query: 148 GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 207
G + YV + +T+ + D D RF +G + +S+LC+PI ++ G++IG+ +
Sbjct: 283 GKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAI 342
Query: 208 RHWGKEA-FCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVA 266
+ A F ++V L + +AI Q+ K+ E + LL+V F+
Sbjct: 343 NKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTD 402
Query: 267 IDSLLEHIMIYAKNLVNADRCALFQVDH---------KNKELYSDLFDIGEEKEGKPVFK 317
++ +++ IM A+ L+ +RC++ ++ K+ EL S E K +
Sbjct: 403 LEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESME 462
Query: 318 KTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRG 376
K+ + I IA VA TG +NI DAY DPRF+ E D +G+ R++LC+PI S
Sbjct: 463 KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNH 522
Query: 377 SVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436
+IGV Q++N++ G F D+ F+ F +FC L ++ MY +++ S V ++ LS
Sbjct: 523 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 582
Query: 437 YHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCF 493
YH+ C+ E +P+ I+ HFD + + + ++M
Sbjct: 583 YHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKI 642
Query: 494 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACL 551
+ E LCR++++V+KNYR V YHNW+HA V M+A+L + T++E +++ CL
Sbjct: 643 DYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCL 702
Query: 552 CHDLDHRGFSNSYLQKFDHPLAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYE 610
CHDLDHRG +N++ K LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY
Sbjct: 703 CHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 762
Query: 611 QVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTK 670
++++++++I+ATDL LYF R + E+ G + N ++HRD ++MTACDL +VTK
Sbjct: 763 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 822
Query: 671 LWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYT 729
W +++ A + +EF+ +GD E +L + P + DR++KDE+P+ QL + +++ +P Y
Sbjct: 823 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 882
Query: 730 TLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
L ++ +P+L + N S+WE++ + A+ SS S A A ED
Sbjct: 883 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASS-SPASVMVAKED 931
Score = 114 bits (284), Expect = 5e-25
Identities = 71/184 (38%), Positives = 104/184 (56%), Gaps = 14/184 (7%)
Query: 245 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK---NKELYS 301
K+ F L++ K N + + SL I+I+ +V+ADRC+LF V+ K L S
Sbjct: 197 KKHNERQFFLELVKD-ISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 302 DLFDIGEEKEGKPVF-----KKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV 356
FD+ G P+ + + E++ KGI G V GE +NIPDAY D RFN E+
Sbjct: 256 KFFDV---HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEI 312
Query: 357 DLYTGYTTRNILCMPI-VSRGSVIGVVQMVNKI-SGSAFSKTDENNFKMFAVFCALALHC 414
D TGY T+++LCMPI S G +IGV Q +NKI G+ F++ DE +M+ FC +A+
Sbjct: 313 DKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISN 372
Query: 415 ANMY 418
A ++
Sbjct: 373 AQLF 376
Score = 32.0 bits (71), Expect = 2.3
Identities = 11/32 (34%), Positives = 21/32 (65%)
Query: 18 KVKAYLSLHPQVLDEFVSESVSAETVEKWLKR 49
+V+ +L HP++ ++++ E VEKWL+R
Sbjct: 10 EVETFLDRHPELFEDYLMRKGKQEMVEKWLQR 41
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 360 bits (923), Expect = 4e-99
Identities = 210/628 (33%), Positives = 346/628 (55%), Gaps = 19/628 (3%)
Query: 170 DERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEA-FCLSHQEVATANLA 228
D RF +G + +S+LC+PI ++ G++IG+ + + A F ++V L
Sbjct: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
Query: 229 WASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCA 288
+ +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +RC+
Sbjct: 115 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 174
Query: 289 LFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGE 339
+ ++ K+ EL S E K +K+ + I IA VA TG
Sbjct: 175 VLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGL 234
Query: 340 VLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDE 398
+NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F D+
Sbjct: 235 PVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQ 294
Query: 399 NNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL 458
F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 295 RLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVS 354
Query: 459 CKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYH 515
I+ HFD + + + ++M + E LCR++++V+KNYR V YH
Sbjct: 355 ELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYH 414
Query: 516 NWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 573
NW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K LA
Sbjct: 415 NWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALA 474
Query: 574 ALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNR 632
LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF R
Sbjct: 475 QLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERR 534
Query: 633 KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD- 691
+ E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +GD
Sbjct: 535 TEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDR 594
Query: 692 EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQ 751
E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N S+
Sbjct: 595 ERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSK 654
Query: 752 WEKVIRGEETATWISSPSVAQKAAASED 779
WE++ + A+ SS S A A ED
Sbjct: 655 WEELHQKRLLASTASS-SPASVMVAKED 681
Score = 37.4 bits (85), Expect = 0.054
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 150 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 209
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 224 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 283
Query: 210 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 253
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 284 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 331
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 208
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 229 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 288
Query: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 289 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 348
Query: 269 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 327
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 349 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 408
Query: 328 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 381
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 409 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 467
Query: 382 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 468 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 527
Query: 437 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 490
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 528 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 587
Query: 491 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 547
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 588 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 647
Query: 548 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 607
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 648 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 707
Query: 608 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 667
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 708 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 767
Query: 668 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 726
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 768 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 827
Query: 727 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 760
Y LT + PLL CR N +W+ + +E
Sbjct: 828 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 267 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 323
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 165 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 222
Query: 324 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 382
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 223 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 282
Query: 383 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 418
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 283 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 320
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 208
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 177 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 236
Query: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 237 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 296
Query: 269 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 327
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 297 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 356
Query: 328 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 381
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 357 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 415
Query: 382 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 416 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 475
Query: 437 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 490
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 476 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 535
Query: 491 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 547
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 536 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 595
Query: 548 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 607
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 596 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 655
Query: 608 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 667
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 656 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 715
Query: 668 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 726
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 716 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 775
Query: 727 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 760
Y LT + PLL CR N +W+ + +E
Sbjct: 776 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 809
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 267 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 323
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 113 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 170
Query: 324 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 382
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 171 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 230
Query: 383 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 418
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 231 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 268
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 208
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 187 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 246
Query: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 247 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 306
Query: 269 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 327
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 307 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 366
Query: 328 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 381
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 367 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 425
Query: 382 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 426 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 485
Query: 437 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 490
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 486 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 545
Query: 491 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 547
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 546 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 605
Query: 548 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 607
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 606 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 665
Query: 608 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 667
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 666 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 725
Query: 668 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 726
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 726 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 785
Query: 727 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 760
Y LT + PLL CR N +W+ + +E
Sbjct: 786 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 267 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 323
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 123 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 180
Query: 324 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 382
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 181 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 240
Query: 383 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 418
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 241 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 278
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 341 bits (875), Expect = 1e-93
Identities = 195/570 (34%), Positives = 317/570 (55%), Gaps = 18/570 (3%)
Query: 227 LAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADR 286
L + +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +R
Sbjct: 5 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 64
Query: 287 CALFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVART 337
C++ ++ K+ EL S E K +K+ + I IA VA T
Sbjct: 65 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 124
Query: 338 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKT 396
G +NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F
Sbjct: 125 GLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDA 184
Query: 397 DENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPV 456
D+ F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 185 DQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPL 244
Query: 457 RLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVP 513
I+ HFD + + + ++M + E LCR++++V+KNYR V
Sbjct: 245 VSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL 304
Query: 514 YHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHP 571
YHNW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K
Sbjct: 305 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 364
Query: 572 LAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFG 630
LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF
Sbjct: 365 LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFE 424
Query: 631 NRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEG 690
R + E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +G
Sbjct: 425 RRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQG 484
Query: 691 D-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNL 749
D E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N
Sbjct: 485 DRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNR 544
Query: 750 SQWEKVIRGEETATWISSPSVAQKAAASED 779
S+WE++ + A+ SS S A A ED
Sbjct: 545 SKWEELHQKRLLASTASS-SPASVMVAKED 573
Score = 37.4 bits (85), Expect = 0.054
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 150 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 209
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 116 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 175
Query: 210 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 253
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 176 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 223
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 329 bits (844), Expect = 5e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 155 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 213
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 290 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 347
Query: 214 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 273
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 348 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 407
Query: 274 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 333
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 408 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 459
Query: 334 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 392
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 460 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 519
Query: 393 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 450
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 520 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 579
Query: 451 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 497
FT R E + + ++M F+ C T
Sbjct: 580 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 629
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 555
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 630 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 689
Query: 556 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 690 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 749
Query: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 750 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 808
Query: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 809 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 867
Query: 734 ILPPTEPLLKACRDNLSQWEKV 755
+ P L + N W KV
Sbjct: 868 LFPKAAELYERVASNREHWTKV 889
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 451 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 508
Query: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAI 234
EL F +++ATA + ++I
Sbjct: 509 AELVNKINGPWFSKFDEDLATAFSIYCGISI 539
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 329 bits (844), Expect = 5e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 155 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 213
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 292 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 349
Query: 214 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 273
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 350 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 409
Query: 274 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 333
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 410 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 461
Query: 334 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 392
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 462 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 521
Query: 393 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 450
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 522 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 581
Query: 451 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 497
FT R E + + ++M F+ C T
Sbjct: 582 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 631
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 555
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 632 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 691
Query: 556 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 692 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 751
Query: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 752 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 810
Query: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 811 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 869
Query: 734 ILPPTEPLLKACRDNLSQWEKV 755
+ P L + N W KV
Sbjct: 870 LFPKAAELYERVASNREHWTKV 891
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 453 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 510
Query: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAI 234
EL F +++ATA + ++I
Sbjct: 511 AELVNKINGPWFSKFDEDLATAFSIYCGISI 541
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 329 bits (844), Expect = 5e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 155 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 213
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 299 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 356
Query: 214 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 273
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 357 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 416
Query: 274 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 333
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 417 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 468
Query: 334 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 392
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
Query: 393 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 450
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
Query: 451 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 497
FT R E + + ++M F+ C T
Sbjct: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 638
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 555
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 639 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 698
Query: 556 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 699 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 758
Query: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 759 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 817
Query: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 818 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 876
Query: 734 ILPPTEPLLKACRDNLSQWEKV 755
+ P L + N W KV
Sbjct: 877 LFPKAAELYERVASNREHWTKV 898
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 460 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 517
Query: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAI 234
EL F +++ATA + ++I
Sbjct: 518 AELVNKINGPWFSKFDEDLATAFSIYCGISI 548
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 319 bits (817), Expect = 7e-87
Identities = 175/479 (36%), Positives = 277/479 (57%), Gaps = 9/479 (1%)
Query: 309 EKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNIL 368
E K +K+ + I IA VA TG +NI DAY DPRF+ E D +G+ R++L
Sbjct: 10 ENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVL 69
Query: 369 CMPIV-SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
C+PI S +IGV Q++N++ G F D+ F+ F +FC L ++ MY +++ S
Sbjct: 70 CVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAK 129
Query: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE---NMWPGIFVYMV 484
V ++ LSYH+ C+ E +P+ I+ HFD + + + ++M
Sbjct: 130 QSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFME 189
Query: 485 HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLE 542
+ E LCR++++V+KNYR V YHNW+HA V M+A+L + T++E
Sbjct: 190 LGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVE 249
Query: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTS-TMEQHHFSQTVSILQLEGHNIF 601
+++ CLCHDLDHRG +N++ K LA LY TS T+E HHF+ V ILQ EGHNIF
Sbjct: 250 ILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIF 309
Query: 602 STLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMT 661
+ LSS EY ++++++++I+ATDL LYF R + E+ G + N ++HRD ++MT
Sbjct: 310 ANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMT 369
Query: 662 ACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
ACDL +VTK W +++ A + +EF+ +GD E +L + P + DR++KDE+P+ QL +
Sbjct: 370 ACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWI 429
Query: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
+++ +P Y L ++ +P+L + N S+WE++ + A+ SS S A A ED
Sbjct: 430 DSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASS-SPASVMVAKED 487
Score = 37.4 bits (85), Expect = 0.054
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 150 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 209
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 30 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 89
Query: 210 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 253
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 90 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 137
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 238 bits (608), Expect = 1e-62
Identities = 183/679 (26%), Positives = 302/679 (44%), Gaps = 72/679 (10%)
Query: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
P+ G + +VA S+K V + DE F + + + +++L PI+ D++ I
Sbjct: 135 PLDMG--IVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNG-KDVVAI 191
Query: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDN 263
+ F +E+ L +A++ + + +T LL F+
Sbjct: 192 IMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEE 251
Query: 264 IVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI---------------GE 308
+ I+ + + +N DR ++ +D ++ + D++ + G
Sbjct: 252 LTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGR 311
Query: 309 E-------------KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP--RFN 353
E KE V +++ G+ VA+ G + NI +A A+ F
Sbjct: 312 EINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQ 371
Query: 354 REVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALAL 412
+E +G+ +N+L MPIV++ ++GV N+ G F + DE + F ++
Sbjct: 372 KEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSV 431
Query: 413 HCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM---------------------- 450
+ Y + E + + + YH C +EE Q ++
Sbjct: 432 LNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEIL 491
Query: 451 QFTLPVRLCKEIELFHFDIGPF---ENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKK 507
Q LP EI FHF P E + GI +Y + E L RF+ S+ K
Sbjct: 492 QAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSK 551
Query: 508 NYRRVPYHNWKHAVTVAHCMYAILQNNHT--LFTDLERKGLLIACLCHDLDHRGFSNSYL 565
YR++ YHNW+H V M+++L FTDLE ++ A CHD+DHRG +N Y
Sbjct: 552 GYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ 611
Query: 566 QKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDL 625
K +PLA L+ +S +E+HH ++L+ E NIF L+ ++E + ++ AIIATDL
Sbjct: 612 MKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDL 671
Query: 626 ALYFGNR----------KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVT 675
ALYF R K E + + Q+ ++ V+ +MMTACDL ++TK W V
Sbjct: 672 ALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQ 731
Query: 676 KLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
A + AEFW +GD E L PIPMMDR+K DE+P+ Q+GF + V Y ++
Sbjct: 732 SQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRF 791
Query: 735 LPPTEPLLKACRDNLSQWE 753
P+L +N +W+
Sbjct: 792 HEEITPMLDGITNNRKEWK 810
Score = 79.7 bits (195), Expect = 9e-15
Identities = 51/175 (29%), Positives = 93/175 (53%), Gaps = 7/175 (4%)
Query: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN--KELYSDLFD 305
E ++ + D+ + + +N+ + + ++M L+ ADR +LF +N EL + LF+
Sbjct: 56 EESEIIFDLLRDFQENLQT-EKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFN 114
Query: 306 IGEEKEGKP-VFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT 364
+ ++ + + +EI F ++ GI G VA + ++ N+P+ D F VD+ T Y T
Sbjct: 115 VHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKT 174
Query: 365 RNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 419
+NIL PI++ V+ ++ VNK+ GS F+K DE + F L + +YH
Sbjct: 175 KNILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM---KVYH 226
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 238 bits (607), Expect = 2e-62
Identities = 202/830 (24%), Positives = 358/830 (43%), Gaps = 116/830 (13%)
Query: 19 VKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYEL 78
V+ YL +PQ E+ + E + + K + + E+++ +++ + EL
Sbjct: 9 VEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEES---ALCLEL 65
Query: 79 NSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPR 138
+++ GG + ++ + +AD +++ N GI E R
Sbjct: 66 LWTVQEE---GGTPEQGVHRALQRLAHLLQADRCSMFLCRSRN---------GIPEVASR 113
Query: 139 LIPAGPITQ----------------GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESG 182
L+ P ++ + + A ++KT V D+ + F ++G
Sbjct: 114 LLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTG 173
Query: 183 TRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRG 242
+++L PIV +++ ++ F +EV + L + S+ +
Sbjct: 174 YVTKNLLATPIVVG-KEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYM 232
Query: 243 LAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDH-KNKELYS 301
++ + L+ + F+ + ++ + ++ +N +R ++ +D K KE Y
Sbjct: 233 YNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYD 292
Query: 302 DL-FDIGEEKEGK-PVFKKTKEIRF-------------------------SIEKGIAGQV 334
+ +GE + K P +E+ F ++ G+ V
Sbjct: 293 EWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYV 352
Query: 335 ARTGEVLNIPDAYADPRFNRE---VDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISG 390
A G + N+ +A AD F + VD TG+ +N+L +PIV++ ++GV N+ G
Sbjct: 353 AENGFICNMMNAPADEYFTFQKGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDG 411
Query: 391 SAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM 450
F + DE + F +L + Y ++ E + E L + T EE + ++
Sbjct: 412 KPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSIL 471
Query: 451 QFTLPVRL-----CKE----------------IELFHFDIGPFENMWPGIFVYMVHRSCG 489
+F + + C+E EL+ F F G+ CG
Sbjct: 472 KFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLI------KCG 525
Query: 490 TSCF-----------ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHT-- 536
F +E L R++ +V+K YR V YHNW+H V M+ +L
Sbjct: 526 IRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKK 585
Query: 537 LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE 596
+TDLE +L A CHD+DHRG +N Y K PLA L+ +S +E+HH + ++LQ E
Sbjct: 586 YYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDE 645
Query: 597 GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLE------EMYQTGSLNLN--- 647
NIF L+ ++E V+ + AIIATDLALYF R + E QT +
Sbjct: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
Query: 648 -NQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMD 705
+ + ++ ++ +MMTACDL ++TK W V A + EFW +GD E L QPIPMMD
Sbjct: 706 VDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMD 765
Query: 706 RDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKV 755
R+K+DE+P+ Q+GF + V Y ++ P+L ++N +W+ +
Sbjct: 766 RNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 231 bits (588), Expect = 3e-60
Identities = 185/678 (27%), Positives = 312/678 (46%), Gaps = 82/678 (12%)
Query: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHW 210
V +VA+++K + VED+ F + + +++L PI+ D++ ++
Sbjct: 138 VVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKL 196
Query: 211 GKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSL 270
F ++V L +A++ + + +T LL + F+ + I+
Sbjct: 197 NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQ 256
Query: 271 LEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI--GEEK--------EGKP-VFKKT 319
+ +N +R ++ +D ++ + D++ + GE + +G+ VF K
Sbjct: 257 FHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKV 316
Query: 320 --------KEIR---------FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--T 360
+EI+ +++ G+ VA +G + NI +A AD F + +
Sbjct: 317 IDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDS 376
Query: 361 GYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 419
G+ +N+L MPIV++ ++GV N+ G F + DE + F ++ + Y
Sbjct: 377 GWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYD 436
Query: 420 RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGP 471
++ E + + + YH C +E +Q LP R C E EL +I
Sbjct: 437 KMNKLENRKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILK 490
Query: 472 FENMWPGIF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKN 508
E P F +Y H S CG + EL E L RF+ S+ K
Sbjct: 491 EELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKG 550
Query: 509 YRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQ 566
YRR+ YHNW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y
Sbjct: 551 YRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQM 610
Query: 567 KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLA 626
K +PLA L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLA
Sbjct: 611 KSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLA 670
Query: 627 LYFGNRKQLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTK 676
LYF R +++ + +S ++ V+ +MMTACDL ++TK W V
Sbjct: 671 LYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQS 730
Query: 677 LTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIL 735
A + AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++
Sbjct: 731 KVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH 790
Query: 736 PPTEPLLKACRDNLSQWE 753
P+ ++N +W+
Sbjct: 791 EEILPMFDRLQNNRKEWK 808
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 6/142 (4%)
Query: 281 LVNADRCALFQVDHKN--KELYSDLFDIGEEKEGKP-VFKKTKEIRFSIEKGIAGQVART 337
L+ ADRC+LF +N EL + LF + + + + EI F ++ G+ G VA+T
Sbjct: 86 LLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQT 145
Query: 338 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTD 397
+++N+ D P F+ D T Y T+N+L PI++ V+ V+ VNK++G F+ D
Sbjct: 146 KKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSED 205
Query: 398 ENNFKMFAVFCALALHCANMYH 419
E+ F + F L L +YH
Sbjct: 206 EDVFLKYLNFATLYL---KIYH 224
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 231 bits (588), Expect = 3e-60
Identities = 185/678 (27%), Positives = 312/678 (46%), Gaps = 82/678 (12%)
Query: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHW 210
V +VA+++K + VED+ F + + +++L PI+ D++ ++
Sbjct: 138 VVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKL 196
Query: 211 GKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSL 270
F ++V L +A++ + + +T LL + F+ + I+
Sbjct: 197 NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQ 256
Query: 271 LEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI--GEEK--------EGKP-VFKKT 319
+ +N +R ++ +D ++ + D++ + GE + +G+ VF K
Sbjct: 257 FHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKV 316
Query: 320 --------KEIR---------FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--T 360
+EI+ +++ G+ VA +G + NI +A AD F + +
Sbjct: 317 IDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDS 376
Query: 361 GYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 419
G+ +N+L MPIV++ ++GV N+ G F + DE + F ++ + Y
Sbjct: 377 GWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYD 436
Query: 420 RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGP 471
++ E + + + YH C +E +Q LP R C E EL +I
Sbjct: 437 KMNKLENRKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILK 490
Query: 472 FENMWPGIF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKN 508
E P F +Y H S CG + EL E L RF+ S+ K
Sbjct: 491 EELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKG 550
Query: 509 YRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQ 566
YRR+ YHNW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y
Sbjct: 551 YRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQM 610
Query: 567 KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLA 626
K +PLA L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLA
Sbjct: 611 KSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLA 670
Query: 627 LYFGNRKQLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTK 676
LYF R +++ + +S ++ V+ +MMTACDL ++TK W V
Sbjct: 671 LYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQS 730
Query: 677 LTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIL 735
A + AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++
Sbjct: 731 KVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH 790
Query: 736 PPTEPLLKACRDNLSQWE 753
P+ ++N +W+
Sbjct: 791 EEILPMFDRLQNNRKEWK 808
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 6/142 (4%)
Query: 281 LVNADRCALFQVDHKN--KELYSDLFDIGEEKEGKP-VFKKTKEIRFSIEKGIAGQVART 337
L+ ADRC+LF +N EL + LF + + + + EI F ++ G+ G VA+T
Sbjct: 86 LLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQT 145
Query: 338 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTD 397
+++N+ D P F+ D T Y T+N+L PI++ V+ V+ VNK++G F+ D
Sbjct: 146 KKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSED 205
Query: 398 ENNFKMFAVFCALALHCANMYH 419
E+ F + F L L +YH
Sbjct: 206 EDVFLKYLNFATLYL---KIYH 224
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 223 bits (569), Expect = 4e-58
Identities = 155/491 (31%), Positives = 237/491 (48%), Gaps = 53/491 (10%)
Query: 310 KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNI 367
KE V +++ G+ VA +G + NI +A AD F + +G+ +N+
Sbjct: 45 KEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNV 104
Query: 368 LCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSEC 426
L MPIV++ ++GV N+ G F + DE + F ++ + Y ++ E
Sbjct: 105 LSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLEN 164
Query: 427 IYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPG 478
+ + + YH C +E +Q LP R C E EL +I E P
Sbjct: 165 RKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPT 218
Query: 479 IF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYH 515
F +Y H S CG + EL E L RF+ S+ K YRR+ YH
Sbjct: 219 TFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYH 278
Query: 516 NWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 573
NW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y K +PLA
Sbjct: 279 NWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA 338
Query: 574 ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRK 633
L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLALYF R
Sbjct: 339 KLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRA 398
Query: 634 QLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
+++ + +S ++ V+ +MMTACDL ++TK W V A +
Sbjct: 399 MFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVA 458
Query: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++ P+
Sbjct: 459 AEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMF 518
Query: 743 KACRDNLSQWE 753
++N +W+
Sbjct: 519 DRLQNNRKEWK 529
Score = 30.0 bits (66), Expect = 8.6
Identities = 18/57 (31%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 153 AYVAKSRKTLLVEDILGDE--RFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 207
+YVA+S + + DE +F G +SG I++VL +PIV +++G+ Y
Sbjct: 67 SYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 120 bits (302), Expect = 4e-27
Identities = 81/272 (29%), Positives = 137/272 (50%), Gaps = 12/272 (4%)
Query: 496 EKLCRFIMSVKKNYR-RVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLC 552
+ L +++ ++ +Y V YHN HA VA + +L +FTDLE L A
Sbjct: 262 DTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAI 321
Query: 553 HDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ 611
HD+DH G SN +L + LA +Y+ S +E HH + +LQ E +IF LS+ +
Sbjct: 322 HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLS 381
Query: 612 VLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMMTACDL 665
+ ++ ++ATD++ + L+ M +T G L L+N S R +V+ ++ DL
Sbjct: 382 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 441
Query: 666 CSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 725
+ TK P+ + + I AEF+ +GD ++ G+ PM D+ V + Q+GF + +A
Sbjct: 442 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTA-SVEKSQVGFIDYIAH 500
Query: 726 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 756
P + T ++ P + LL DN ++ I
Sbjct: 501 PLWETWADLVHPDAQDLLDTLEDNREWYQSKI 532
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 120 bits (302), Expect = 4e-27
Identities = 81/272 (29%), Positives = 137/272 (50%), Gaps = 12/272 (4%)
Query: 496 EKLCRFIMSVKKNYR-RVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLC 552
+ L +++ ++ +Y V YHN HA VA + +L +FTDLE L A
Sbjct: 336 DTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAI 395
Query: 553 HDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ 611
HD+DH G SN +L + LA +Y+ S +E HH + +LQ E +IF LS+ +
Sbjct: 396 HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLS 455
Query: 612 VLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMMTACDL 665
+ ++ ++ATD++ + L+ M +T G L L+N S R +V+ ++ DL
Sbjct: 456 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 515
Query: 666 CSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 725
+ TK P+ + + I AEF+ +GD ++ G+ PM D+ V + Q+GF + +A
Sbjct: 516 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTA-SVEKSQVGFIDYIAH 574
Query: 726 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 756
P + T ++ P + LL DN ++ I
Sbjct: 575 PLWETWADLVHPDAQDLLDTLEDNREWYQSKI 606
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 120 bits (302), Expect = 4e-27
Identities = 81/272 (29%), Positives = 137/272 (50%), Gaps = 12/272 (4%)
Query: 496 EKLCRFIMSVKKNYR-RVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLC 552
+ L +++ ++ +Y V YHN HA VA + +L +FTDLE L A
Sbjct: 368 DTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAI 427
Query: 553 HDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ 611
HD+DH G SN +L + LA +Y+ S +E HH + +LQ E +IF LS+ +
Sbjct: 428 HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLS 487
Query: 612 VLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMMTACDL 665
+ ++ ++ATD++ + L+ M +T G L L+N S R +V+ ++ DL
Sbjct: 488 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 547
Query: 666 CSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 725
+ TK P+ + + I AEF+ +GD ++ G+ PM D+ V + Q+GF + +A
Sbjct: 548 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTA-SVEKSQVGFIDYIAH 606
Query: 726 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 756
P + T ++ P + LL DN ++ I
Sbjct: 607 PLWETWADLVHPDAQDLLDTLEDNREWYQSKI 638
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 88 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 147
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 148 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 207
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 208 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 265
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 266 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 324
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 325 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 369
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 88 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 147
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 148 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 207
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 208 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 265
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 266 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 324
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 325 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 369
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 269 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 328
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 329 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 388
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 389 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 446
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 447 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 505
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 506 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 550
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 254 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 313
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 314 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 373
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 374 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 431
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 432 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 490
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 491 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 535
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 228 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 287
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 288 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 347
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 348 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 405
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 406 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 464
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 465 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 509
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 78 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 137
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 138 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 197
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 198 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 255
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 256 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 314
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 315 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 359
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 88 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 147
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 148 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 207
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 208 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 265
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 266 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 324
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 325 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 369
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 193 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 252
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 253 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 312
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 313 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 370
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 371 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 429
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 430 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 474
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 161 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 220
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 221 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 280
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 281 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 338
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 339 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 397
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 398 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 442
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 555
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 78 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 137
Query: 556 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 614
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 138 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 197
Query: 615 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 674
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 198 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 255
Query: 675 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 256 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 314
Query: 735 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 778
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 315 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 359
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,716,804
Number of Sequences: 37866
Number of extensions: 1271688
Number of successful extensions: 3149
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2767
Number of HSP's gapped (non-prelim): 129
length of query: 779
length of database: 18,247,518
effective HSP length: 110
effective length of query: 669
effective length of database: 14,082,258
effective search space: 9421030602
effective search space used: 9421030602
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.