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Search of human proteins with 134254459
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
(1099 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 2196 0.0
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 1361 0.0
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 1061 0.0
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 1061 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 1058 0.0
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 278 3e-74
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 245 1e-64
gi|198041678 solute carrier family 12 (potassium-chloride transp... 213 1e-54
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 213 1e-54
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 212 1e-54
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 212 1e-54
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 212 1e-54
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 212 1e-54
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 212 1e-54
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 211 2e-54
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 211 2e-54
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 211 2e-54
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 211 2e-54
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 211 2e-54
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 211 2e-54
gi|123701900 solute carrier family 12 (potassium/chloride transp... 208 3e-53
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 46 2e-04
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 44 6e-04
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 43 0.002
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 42 0.002
gi|71999149 solute carrier family 7, (cationic amino acid transp... 39 0.027
gi|114326550 solute carrier family 7 (cationic amino acid transp... 38 0.060
gi|114326544 solute carrier family 7 (cationic amino acid transp... 38 0.060
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 37 0.13
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 33 1.1
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo sapiens]
Length = 1099
Score = 2196 bits (5689), Expect = 0.0
Identities = 1099/1099 (100%), Positives = 1099/1099 (100%)
Query: 1 MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRI 60
MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRI
Sbjct: 1 MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRI 60
Query: 61 SFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGS 120
SFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGS
Sbjct: 61 SFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGS 120
Query: 121 ISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWV 180
ISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWV
Sbjct: 121 ISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWV 180
Query: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR 240
KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR
Sbjct: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR 240
Query: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTND 300
GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTND
Sbjct: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTND 300
Query: 301 IRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFN 360
IRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFN
Sbjct: 301 IRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFN 360
Query: 361 YQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIF 420
YQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIF
Sbjct: 361 YQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIF 420
Query: 421 ITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLM 480
ITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLM
Sbjct: 421 ITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLM 480
Query: 481 NNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK 540
NNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK
Sbjct: 481 NNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK 540
Query: 541 NNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPA 600
NNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPA
Sbjct: 541 NNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPA 600
Query: 601 YGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSY 660
YGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSY
Sbjct: 601 YGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSY 660
Query: 661 VSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGP 720
VSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGP
Sbjct: 661 VSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGP 720
Query: 721 RKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIG 780
RKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIG
Sbjct: 721 RKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIG 780
Query: 781 YKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLA 840
YKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLA
Sbjct: 781 YKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLA 840
Query: 841 LEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEAST 900
LEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEAST
Sbjct: 841 LEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEAST 900
Query: 901 QFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMA 960
QFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMA
Sbjct: 901 QFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMA 960
Query: 961 SLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWK 1020
SLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWK
Sbjct: 961 SLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWK 1020
Query: 1021 ITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKN 1080
ITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKN
Sbjct: 1021 ITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKN 1080
Query: 1081 LPPVLLVRGNHKNVLTFYS 1099
LPPVLLVRGNHKNVLTFYS
Sbjct: 1081 LPPVLLVRGNHKNVLTFYS 1099
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 1361 bits (3523), Expect = 0.0
Identities = 703/1151 (61%), Positives = 858/1151 (74%), Gaps = 72/1151 (6%)
Query: 11 LDSVPSNTNRFQVSVINENHESSAAAD---------------------DNTDPPHYEETS 49
L PS + RFQV +++EN +AAA D E
Sbjct: 72 LGPTPSQS-RFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAK 130
Query: 50 FGDEAQKRLRISF--RPGNQECYDN---------------FLQSGETAKTDAS------- 85
+EA+ R R++F + D+ F G+T ++ S
Sbjct: 131 GSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGG 190
Query: 86 -------FHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQL 138
+ YD+HTNTYYL+TFGHNTMDAVP+I++YR+T + G K+ RPSL E+H++L
Sbjct: 191 GGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDEL 250
Query: 139 AKNVAVTPSSADRVANGD-GIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLF 197
K D ANG+ P + + GVVKFGW+KGVLVRCMLNIWGVMLF
Sbjct: 251 EKE-----PFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLF 305
Query: 198 IRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG 257
IRLSWIVG+AGIGL VL+I+++T+VT+ITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG
Sbjct: 306 IRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG 365
Query: 258 GSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISV 317
G+IGLIFAFANAVAVAMYVVGFAETVV+LLKE +M+D NDIRIIG+ITVVILLGISV
Sbjct: 366 GAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISV 425
Query: 318 AGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKG 377
AGMEWEAKAQ++LLVILL+AI +F IGT IP + KK +GFF Y++ IF ENFGP F +
Sbjct: 426 AGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES-KKPKGFFGYKSEIFNENFGPDFREE 484
Query: 378 EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACV 437
E FFSVFAIFFPAATGILAGANISGDL DPQ AIP+GT+LAI ITT+ Y+G+A+ VG+CV
Sbjct: 485 ETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCV 544
Query: 438 VRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
VRDATGN+NDTI++ + SAAC L +DFS C PC YGLMNNFQVMSMVSGF PLI+
Sbjct: 545 VRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLIS 604
Query: 498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMA 557
AGIFSATLSSALASLVSAPK+FQALCKDNIY A Q FAKGYGKNNEPLRGYILTFLIA+
Sbjct: 605 AGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALG 664
Query: 558 FILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCC 617
FILIAELN IAPIISNFFLASYALINFS FHAS AKSPGWRPA+ YNMW+SL GA+LCC
Sbjct: 665 FILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCC 724
Query: 618 AVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHV 677
VMFVINWWAA++TYVI LY+YVT KKPDVNWGSSTQAL+Y++AL +++ L+ VEDHV
Sbjct: 725 IVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHV 784
Query: 678 KNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
KNFRPQC+V+TG P +RPALL + H FTKN GL IC V +GPR+ +KEM+ AK Q
Sbjct: 785 KNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQR 844
Query: 738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYV 797
WLIKNK+KAFYA V AD R+G + L+QA+GLGRMKPNTLV+G+KK+W +A + +++ Y+
Sbjct: 845 WLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYI 904
Query: 798 GIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGI 857
+ HDAFD + GVV++R+ +G DIS LQ QEEL +++ + + E ++S
Sbjct: 905 NLFHDAFDIQYGVVVIRLKEGLDISH-LQGQEELLSSQEKSPGTKDVVVSVEYSKKSD-- 961
Query: 858 RGLFKKAGKLNITKTTPKKDGSINTSQSMH---------VGEFNQKLVEASTQFKKKQEK 908
K + IT ++DG T + + +QKL+EASTQF+KKQ K
Sbjct: 962 LDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGK 1021
Query: 909 GTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRI 968
TIDVWWLFDDGGLTLLIPY+LT +KKWKDCK+R+++GGKINRI+ ++ MA+LLSKFRI
Sbjct: 1022 NTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRI 1081
Query: 969 KFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEA 1028
F+DI ++GDIN +P KE+ FEE+IEPYRLHE K+ A+K+K + PW+ITD ELE
Sbjct: 1082 DFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELEL 1141
Query: 1029 VKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVR 1088
K K+YRQ+RLNELL+EHS AN+IV+SLPVARKG++S LYMAWLE L+K+LPP+LLVR
Sbjct: 1142 YKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVR 1201
Query: 1089 GNHKNVLTFYS 1099
GNH++VLTFYS
Sbjct: 1202 GNHQSVLTFYS 1212
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 1061 bits (2744), Expect = 0.0
Identities = 533/1025 (52%), Positives = 720/1025 (70%), Gaps = 38/1025 (3%)
Query: 80 AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLA 139
A D+S ++ +H++T+ ++TFG+NT+D VP E+Y N+ P+ RP+L ++H L
Sbjct: 35 AAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK 94
Query: 140 KNV---AVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVML 196
+ A+ S DG+ E + E + V+FGWVKGV++RCMLNIWGV+L
Sbjct: 95 EGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVIL 154
Query: 197 FIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEF 256
++RL WI +AGI L +IILLS VTSITGLS SAI+TNG V+ GG Y+LISRSLGPE
Sbjct: 155 YLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPEL 214
Query: 257 GGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGIS 316
GGSIGLIFAFANAV VAM+ VGFAETV DLL+E + +VDP NDIRIIG ++V +LL IS
Sbjct: 215 GGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAIS 274
Query: 317 VAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTK 376
+AGMEWE+KAQV+ ++++++ AN+ +GT+IP + +K S+GFF+Y+A IF +N P +
Sbjct: 275 LAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRG 334
Query: 377 GEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGA 435
+G FF +F+IFFP+ATGILAGANISGDL+DP AIP+GT++AIF TT++YL ++ +G+
Sbjct: 335 PDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGS 394
Query: 436 CVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHE-PCQYGLMNNFQVMSMVSGFGP 494
CVVRDA+G +NDT+ G AC G++F+ C + C YGL+N +Q MSMVSGF P
Sbjct: 395 CVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP 454
Query: 495 LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLI 554
LITAGIF ATLSSALA LVSA KVFQ LC+D +Y + FF KGYGKN EP+RGY+L + I
Sbjct: 455 LITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAI 514
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A+AFI+IAELNTIAPIISNFFL SYALINFSCFHAS SPGWRP++ YN W +LFGA+
Sbjct: 515 AVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAI 574
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+ +MF++ WWAA+I + FL +YV KKP+VNWGSS QA SY AL ++ L VE
Sbjct: 575 ISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVE 634
Query: 675 DHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAK 734
DH+KN+RPQC+VLTG P RPAL+D FT+N L IC V +GP K + E+
Sbjct: 635 DHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANG 694
Query: 735 KQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIE 794
WL K KIKAFY+ V A+ R GV+ L+QA+GLGRMKPN LV+G+KKNW+ A +E
Sbjct: 695 HTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVE 754
Query: 795 NYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEES 854
+Y+GI+HDAFDF GV ++R+ +G ++S+++Q + D + +
Sbjct: 755 DYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHIN-------------PVFDPAEDGKE 801
Query: 855 GGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVW 914
RG P G+++ + K +A+T F+ +Q K TID++
Sbjct: 802 ASARG------------ARPSVSGALDPKALV-------KEEQATTIFQSEQGKKTIDIY 842
Query: 915 WLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIH 974
WLFDDGGLTLLIPY+L +++W CK+R++VGG+INR+++E+ + SLLSKFR+ F ++H
Sbjct: 843 WLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVH 902
Query: 975 IIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSY 1034
I+ DIN P E K FE+MI P+RL++ KD T +++R+ PWKI+D E+ + KS
Sbjct: 903 ILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSL 962
Query: 1035 RQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNL-PPVLLVRGNHKN 1093
RQVRLNE++ ++SR A LIV++LP+ RKG LYMAWLE L+++L PPV+L+RGN +N
Sbjct: 963 RQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQEN 1022
Query: 1094 VLTFY 1098
VLTFY
Sbjct: 1023 VLTFY 1027
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 1061 bits (2743), Expect = 0.0
Identities = 533/1026 (51%), Positives = 720/1026 (70%), Gaps = 39/1026 (3%)
Query: 80 AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLA 139
A D+S ++ +H++T+ ++TFG+NT+D VP E+Y N+ P+ RP+L ++H L
Sbjct: 35 AAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK 94
Query: 140 KNV----AVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVM 195
+ A+ S DG+ E + E + V+FGWVKGV++RCMLNIWGV+
Sbjct: 95 QEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVI 154
Query: 196 LFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPE 255
L++RL WI +AGI L +IILLS VTSITGLS SAI+TNG V+ GG Y+LISRSLGPE
Sbjct: 155 LYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPE 214
Query: 256 FGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGI 315
GGSIGLIFAFANAV VAM+ VGFAETV DLL+E + +VDP NDIRIIG ++V +LL I
Sbjct: 215 LGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAI 274
Query: 316 SVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFT 375
S+AGMEWE+KAQV+ ++++++ AN+ +GT+IP + +K S+GFF+Y+A IF +N P +
Sbjct: 275 SLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWR 334
Query: 376 KGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVG 434
+G FF +F+IFFP+ATGILAGANISGDL+DP AIP+GT++AIF TT++YL ++ +G
Sbjct: 335 GPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIG 394
Query: 435 ACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHE-PCQYGLMNNFQVMSMVSGFG 493
+CVVRDA+G +NDT+ G AC G++F+ C + C YGL+N +Q MSMVSGF
Sbjct: 395 SCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFA 454
Query: 494 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFL 553
PLITAGIF ATLSSALA LVSA KVFQ LC+D +Y + FF KGYGKN EP+RGY+L +
Sbjct: 455 PLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYA 514
Query: 554 IAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGA 613
IA+AFI+IAELNTIAPIISNFFL SYALINFSCFHAS SPGWRP++ YN W +LFGA
Sbjct: 515 IAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGA 574
Query: 614 VLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTV 673
++ +MF++ WWAA+I + FL +YV KKP+VNWGSS QA SY AL ++ L V
Sbjct: 575 IISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEV 634
Query: 674 EDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMA 733
EDH+KN+RPQC+VLTG P RPAL+D FT+N L IC V +GP K + E+
Sbjct: 635 EDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
Query: 734 KKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEI 793
WL K KIKAFY+ V A+ R GV+ L+QA+GLGRMKPN LV+G+KKNW+ A +
Sbjct: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATV 754
Query: 794 ENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEE 853
E+Y+GI+HDAFDF GV ++R+ +G ++S+++Q + D + +
Sbjct: 755 EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHIN-------------PVFDPAEDGK 801
Query: 854 SGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDV 913
RG P G+++ + K +A+T F+ +Q K TID+
Sbjct: 802 EASARG------------ARPSVSGALDPKALV-------KEEQATTIFQSEQGKKTIDI 842
Query: 914 WWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADI 973
+WLFDDGGLTLLIPY+L +++W CK+R++VGG+INR+++E+ + SLLSKFR+ F ++
Sbjct: 843 YWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEV 902
Query: 974 HIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKS 1033
HI+ DIN P E K FE+MI P+RL++ KD T +++R+ PWKI+D E+ + KS
Sbjct: 903 HILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKS 962
Query: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNL-PPVLLVRGNHK 1092
RQVRLNE++ ++SR A LIV++LP+ RKG LYMAWLE L+++L PPV+L+RGN +
Sbjct: 963 LRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQE 1022
Query: 1093 NVLTFY 1098
NVLTFY
Sbjct: 1023 NVLTFY 1028
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 1058 bits (2735), Expect = 0.0
Identities = 535/1028 (52%), Positives = 717/1028 (69%), Gaps = 52/1028 (5%)
Query: 80 AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLA 139
A D+S ++ +H++T+ ++TFG+NT+D VP E+Y N+ P+ RP+L ++H L
Sbjct: 35 AAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLK 94
Query: 140 KNV----AVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVM 195
+ A+ S DG+ E + E + V+FGWVKGV++RCMLNIWGV+
Sbjct: 95 QEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVI 154
Query: 196 LFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPE 255
L++RL WI +AGI L +IILLS VTSITGLS SAI+TNG V+ GG Y+LISRSLGPE
Sbjct: 155 LYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPE 214
Query: 256 FGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGI 315
GGSIGLIFAFANAV VAM+ VGFAETV DLL+E + +VDP NDIRIIG ++V +LL I
Sbjct: 215 LGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAI 274
Query: 316 SVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFT 375
S+AGMEWE+KAQV+ ++++++ AN+ +GT+IP + +K S+GFF+Y+A IF +N P +
Sbjct: 275 SLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWR 334
Query: 376 KGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVG 434
+G FF +F+IFFP+ATGILAGANISGDL+DP AIP+GT++AIF TT++YL ++ +G
Sbjct: 335 GPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIG 394
Query: 435 ACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHE-PCQYGLMNNFQVMSMVSGFG 493
+CVVRDA+G +NDT+ G AC G++F+ C + C YGL+N +Q MSMVSGF
Sbjct: 395 SCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFA 454
Query: 494 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFL 553
PLITAGIF ATLSSALA LVSA KVFQ LC+D +Y + FF KGYGKN EP+RGY+L +
Sbjct: 455 PLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYA 514
Query: 554 IAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGA 613
IA+AFI+IAELNTIAPIISNFFL SYALINFSCFHAS SPGWRP++ YN W +LFGA
Sbjct: 515 IAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGA 574
Query: 614 VLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTV 673
++ +MF++ WWAA+I + FL +YV KKP+VNWGSS QA SY AL ++ L V
Sbjct: 575 IISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEV 634
Query: 674 EDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMA 733
EDH+KN+RPQC+VLTG P RPAL+D FT+N L IC V +GP K + E+
Sbjct: 635 EDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
Query: 734 KKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEI 793
WL K KIKAFY+ V A+ R GV+ L+QA+GLGRMKPN LV+G+KKNW+ A +
Sbjct: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATV 754
Query: 794 ENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEE 853
E+Y+GI+HDAFDF GV ++R+ +G ++S+++Q
Sbjct: 755 EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH------------------------- 789
Query: 854 SGGIRGLFKKA--GKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTI 911
I +F A GK + PK K +A+T F+ +Q K TI
Sbjct: 790 ---INPVFDPAEDGKEASARVDPKA---------------LVKEEQATTIFQSEQGKKTI 831
Query: 912 DVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFA 971
D++WLFDDGGLTLLIPY+L +++W CK+R++VGG+INR+++E+ + SLLSKFR+ F
Sbjct: 832 DIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFH 891
Query: 972 DIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKE 1031
++HI+ DIN P E K FE+MI P+RL++ KD T +++R+ PWKI+D E+ +
Sbjct: 892 EVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRV 951
Query: 1032 KSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNL-PPVLLVRGN 1090
KS RQVRLNE++ ++SR A LIV++LP+ RKG LYMAWLE L+++L PPV+L+RGN
Sbjct: 952 KSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGN 1011
Query: 1091 HKNVLTFY 1098
+NVLTFY
Sbjct: 1012 QENVLTFY 1019
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 278 bits (710), Expect = 3e-74
Identities = 189/665 (28%), Positives = 330/665 (49%), Gaps = 92/665 (13%)
Query: 153 ANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLG 212
ANG G PG A K GV+V +L+++ +++F+R+ ++VG AG+
Sbjct: 23 ANGAGGPGGASAR----------KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQA 72
Query: 213 VLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAV 272
+ ++L++ + ++T LS AIATNG V+GGGAY++ISR+LGPE GGSIGL+F AN
Sbjct: 73 LAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGC 132
Query: 273 AMYVVGFAETVVDLLKESDSMMVDPTNDIRII----------GSITVVILLGISVAGMEW 322
A+ ++G E+V+D+ + + +R++ GS+ + ++ G+ G
Sbjct: 133 AVSLLGLVESVLDVFGADAT----GPSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGL 188
Query: 323 EAKAQVILLVILLIAIANFFIGTVI-------------PSNNEKKSR--GFFNYQASIFA 367
A+A + +++ ++A+ I V P+ + R F + +S
Sbjct: 189 YARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLK 248
Query: 368 ENFGPRFTKGE------GFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFI 421
+N G + + F SVFA+ F TGI+AGAN+SG+L+DP AIP GT++A+
Sbjct: 249 DNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAY 308
Query: 422 TTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMN 481
T Y+ + +S C+ + L
Sbjct: 309 TFFVYVLLFF------------------LSSFTCDRTL-------------------LQE 331
Query: 482 NFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKN 541
++ +S + PL+ GI++ LS++++SL+ A ++ AL +D+++ + AK +
Sbjct: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 391
Query: 542 NEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAY 601
P + ++ + +L +LNT+A +++ F+L +YA ++ SC +A +P +RP +
Sbjct: 392 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 451
Query: 602 GIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYV 661
+++ L G C +MF+I+ AA + ++ L +T + +WG +QAL +
Sbjct: 452 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 511
Query: 662 SALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPR 721
L L +DHVK +RPQ ++L G P LL + + K GL + V +G
Sbjct: 512 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGD- 569
Query: 722 KLCVKEMNSGMAKKQ--AWLI---KNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNT 776
+ + S + Q AWL + ++KAF + R G + LL+ SGLG MKPNT
Sbjct: 570 ---LDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNT 626
Query: 777 LVIGY 781
LV+G+
Sbjct: 627 LVLGF 631
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 245 bits (626), Expect = 1e-64
Identities = 137/416 (32%), Positives = 220/416 (52%), Gaps = 46/416 (11%)
Query: 175 VKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIA 234
V FG GV CM+NI+GV+LF+R W+VG G+ LG+ ++ +V +T LS +
Sbjct: 37 VLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVG 96
Query: 235 TNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMM 294
+ GG Y +IS LG + GG+IGL++ F VA AMY+ GFAE++ DLL +
Sbjct: 97 ERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWA 156
Query: 295 VDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKK 354
V R I ++ LLGI++AG++W + Q++LL +L ++ +F +G+ + E
Sbjct: 157 V------RGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPE-- 208
Query: 355 SRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRG 414
GF Y + N P ++ GE FF+VF +FFPAATG++AG N+ GDL +P +IP G
Sbjct: 209 -HGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLG 267
Query: 415 TMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEP 474
++ A+ I+ Y+ +GA R+A L YD
Sbjct: 268 SLAAVGISWFLYIVFVFLLGAICTREA---------------------LRYD-------- 298
Query: 475 CQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFF 534
F + VS G L G++ ++L+S + L AP++ Q + ++ + AL
Sbjct: 299 --------FLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACL 350
Query: 535 AKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHAS 590
+G G N P+ LT L+ MAF+ + ++N +API++ F+ +Y +++S F S
Sbjct: 351 GQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLS 406
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Query: 597 WRPAYGIY----NMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWG 652
WR + Y N WVSL GAV +MFVI W ++ + +Y Y+ P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 653 SST 655
S++
Sbjct: 642 SAS 644
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 213 bits (541), Expect = 1e-54
Identities = 138/445 (31%), Positives = 214/445 (48%), Gaps = 45/445 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ Y+ + GAC
Sbjct: 423 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G NG+ G ++ S + +
Sbjct: 483 VVLRDKFGEA---------VNGNLVVG----------------------TLAWPSPW--V 509
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ +D I LQ F G+GK N EP +LT I
Sbjct: 510 IVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTWALLLTACI 567
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 568 CEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMS 627
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MF+ +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 628 LCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGP 687
Query: 675 DHVKNFRPQCIVLT----GGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL +T GL I V G +
Sbjct: 688 PHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQR 747
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR-KAP 789
+ + K+K F V + RDGV L+Q+ GLG ++ NT+++G+ +NWR K
Sbjct: 748 AEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKED 807
Query: 790 LTEIENYVGIIHDAFDFEIGVVIVR 814
N++ ++ + + +++ +
Sbjct: 808 HQTWRNFIELVRETTAGHLALLVTK 832
Score = 127 bits (318), Expect = 8e-29
Identities = 78/251 (31%), Positives = 129/251 (51%), Gaps = 26/251 (10%)
Query: 122 SGPKVNRPSLLEIHEQLAKNVAVTPSSADR----------VANGDGIP-GDEQAENKEDD 170
S P +N + E KN+A+ D +AN +P G + E E++
Sbjct: 48 SSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENN 107
Query: 171 QAGVVK------FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTS 224
+ G K G GV + C+ NI+GV+LF+RL+W+VG AGI ++ + T
Sbjct: 108 EGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTM 167
Query: 225 ITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV 284
+T +S SAIATNG V GG+YY+ISRSLGPEFGG++GL F A AMY++G E ++
Sbjct: 168 LTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILL 227
Query: 285 DLL---------KESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILL 335
L +++ N++R+ G+ + + + G+++ K ++ L ++
Sbjct: 228 AYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVI 287
Query: 336 IAIANFFIGTV 346
++I + G +
Sbjct: 288 LSILAIYAGVI 298
Score = 59.3 bits (142), Expect = 2e-08
Identities = 42/117 (35%), Positives = 67/117 (57%), Gaps = 13/117 (11%)
Query: 996 EPYRLHES-CKDLTTAEKLKRETPWK---ITD-----AELEAVKEKSYRQ----VRLNEL 1042
+P ++H + KD + AEK K +P I D E E + + + R+ VRLNE+
Sbjct: 1023 DPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEV 1082
Query: 1043 LQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
+ + SR A L++L++P + D YM +LE+LT++L V+LVRG + V+T YS
Sbjct: 1083 IVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
Score = 58.5 bits (140), Expect = 3e-08
Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFR 967
+G+IDVWW+ DGG+ +L+P++L K W+ CK+RI+ + ++++ I M L+ F
Sbjct: 846 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFT---VAQMDDNSIQMKKDLTTFL 902
Query: 968 IKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELE 1027
+ + + + S +E+ + + + K + + + ITD
Sbjct: 903 YHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRG 962
Query: 1028 AVKEKSYRQVRL 1039
+++ K+ RL
Sbjct: 963 SIRRKNPANTRL 974
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 213 bits (541), Expect = 1e-54
Identities = 138/445 (31%), Positives = 214/445 (48%), Gaps = 45/445 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ Y+ + GAC
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 459
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G NG+ G ++ S + +
Sbjct: 460 VVLRDKFGEA---------VNGNLVVG----------------------TLAWPSPW--V 486
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ +D I LQ F G+GK N EP +LT I
Sbjct: 487 IVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTWALLLTACI 544
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 545 CEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMS 604
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MF+ +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 605 LCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGP 664
Query: 675 DHVKNFRPQCIVLT----GGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL +T GL I V G +
Sbjct: 665 PHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQR 724
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR-KAP 789
+ + K+K F V + RDGV L+Q+ GLG ++ NT+++G+ +NWR K
Sbjct: 725 AEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKED 784
Query: 790 LTEIENYVGIIHDAFDFEIGVVIVR 814
N++ ++ + + +++ +
Sbjct: 785 HQTWRNFIELVRETTAGHLALLVTK 809
Score = 128 bits (322), Expect = 3e-29
Identities = 80/263 (30%), Positives = 138/263 (52%), Gaps = 19/263 (7%)
Query: 102 GHNTMDAVPKIE--YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIP 159
G N D PK + +T + G + + ++ E++ + V+ S +AN +P
Sbjct: 14 GANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVS-SLLSGLANYTNLP 72
Query: 160 -GDEQAENKEDDQAGVVK------FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLG 212
G + E E+++ G K G GV + C+ NI+GV+LF+RL+W+VG AGI
Sbjct: 73 QGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMES 132
Query: 213 VLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAV 272
++ + T +T +S SAIATNG V GG+YY+ISRSLGPEFGG++GL F A
Sbjct: 133 FCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAG 192
Query: 273 AMYVVGFAETVVDLL---------KESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWE 323
AMY++G E ++ L +++ N++R+ G+ + + + G+++
Sbjct: 193 AMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYV 252
Query: 324 AKAQVILLVILLIAIANFFIGTV 346
K ++ L ++++I + G +
Sbjct: 253 NKFALVFLGCVILSILAIYAGVI 275
Score = 59.3 bits (142), Expect = 2e-08
Identities = 42/117 (35%), Positives = 67/117 (57%), Gaps = 13/117 (11%)
Query: 996 EPYRLHES-CKDLTTAEKLKRETPWK---ITD-----AELEAVKEKSYRQ----VRLNEL 1042
+P ++H + KD + AEK K +P I D E E + + + R+ VRLNE+
Sbjct: 1000 DPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEV 1059
Query: 1043 LQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
+ + SR A L++L++P + D YM +LE+LT++L V+LVRG + V+T YS
Sbjct: 1060 IVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1116
Score = 58.5 bits (140), Expect = 3e-08
Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFR 967
+G+IDVWW+ DGG+ +L+P++L K W+ CK+RI+ + ++++ I M L+ F
Sbjct: 823 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFT---VAQMDDNSIQMKKDLTTFL 879
Query: 968 IKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELE 1027
+ + + + S +E+ + + + K + + + ITD
Sbjct: 880 YHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRG 939
Query: 1028 AVKEKSYRQVRL 1039
+++ K+ RL
Sbjct: 940 SIRRKNPANTRL 951
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 389 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 448
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ N V ++ +
Sbjct: 449 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 475
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 476 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 533
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 534 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 593
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 594 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 653
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 654 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 713
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 714 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 771
Score = 128 bits (321), Expect = 3e-29
Identities = 79/254 (31%), Positives = 134/254 (52%), Gaps = 23/254 (9%)
Query: 106 MDAVPKIEYY-RNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQA 164
++A I+YY RN RP + + +L +T + + E+A
Sbjct: 22 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEH----------EEA 71
Query: 165 ENKEDDQ---AGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTM 221
E+ E + A G + GV + C+ NI+GV+LF+RL+W+VG AG+ +LI+L+
Sbjct: 72 ESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCC 131
Query: 222 VTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAE 281
T +T +S SAIATNG V GG+Y++ISRSLGPEFGG++GL F A AMY++G E
Sbjct: 132 CTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 191
Query: 282 TVVDLLKESDSMMVD---------PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLV 332
++ + ++ N++R+ G+I + + + G+++ K + L
Sbjct: 192 ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLA 251
Query: 333 ILLIAIANFFIGTV 346
++I+I + + G +
Sbjct: 252 CVIISILSIYAGGI 265
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/246 (26%), Positives = 117/246 (47%), Gaps = 57/246 (23%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKI--NRIEEEKIVMASLLSK 965
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ ++ N I+ +K +A L
Sbjct: 812 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKD-LAVFLYH 870
Query: 966 FRIKFADIHII----GDINIRPNKESWKVFE--EMIEPYRLHESCKDLT----------- 1008
R++ A++ ++ DI+ + + + + +M+ RL ++ ++
Sbjct: 871 LRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 929
Query: 1009 ------------------------TAEKLKRETPWKITDA-----ELEAVK------EKS 1033
T +K ET W + A EL +K +
Sbjct: 930 RLESLYSDEEDESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRM 988
Query: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKN 1093
+ V+LNE++ S A L++L++P + S D YM +LE+LT+ L VLLVRG +
Sbjct: 989 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE 1048
Query: 1094 VLTFYS 1099
V+T YS
Sbjct: 1049 VITIYS 1054
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 414 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 473
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ N V ++ +
Sbjct: 474 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 500
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 501 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 558
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 559 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 618
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 619 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 678
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 679 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 738
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 739 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 796
Score = 128 bits (321), Expect = 3e-29
Identities = 79/254 (31%), Positives = 134/254 (52%), Gaps = 23/254 (9%)
Query: 106 MDAVPKIEYY-RNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQA 164
++A I+YY RN RP + + +L +T + + E+A
Sbjct: 47 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEH----------EEA 96
Query: 165 ENKEDDQ---AGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTM 221
E+ E + A G + GV + C+ NI+GV+LF+RL+W+VG AG+ +LI+L+
Sbjct: 97 ESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCC 156
Query: 222 VTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAE 281
T +T +S SAIATNG V GG+Y++ISRSLGPEFGG++GL F A AMY++G E
Sbjct: 157 CTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 216
Query: 282 TVVDLLKESDSMMVD---------PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLV 332
++ + ++ N++R+ G+I + + + G+++ K + L
Sbjct: 217 ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLA 276
Query: 333 ILLIAIANFFIGTV 346
++I+I + + G +
Sbjct: 277 CVIISILSIYAGGI 290
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/246 (26%), Positives = 117/246 (47%), Gaps = 57/246 (23%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKI--NRIEEEKIVMASLLSK 965
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ ++ N I+ +K +A L
Sbjct: 837 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKD-LAVFLYH 895
Query: 966 FRIKFADIHII----GDINIRPNKESWKVFE--EMIEPYRLHESCKDLT----------- 1008
R++ A++ ++ DI+ + + + + +M+ RL ++ ++
Sbjct: 896 LRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 954
Query: 1009 ------------------------TAEKLKRETPWKITDA-----ELEAVK------EKS 1033
T +K ET W + A EL +K +
Sbjct: 955 RLESLYSDEEDESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRM 1013
Query: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKN 1093
+ V+LNE++ S A L++L++P + S D YM +LE+LT+ L VLLVRG +
Sbjct: 1014 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE 1073
Query: 1094 VLTFYS 1099
V+T YS
Sbjct: 1074 VITIYS 1079
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 422 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 481
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ N V ++ +
Sbjct: 482 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 508
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 509 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 566
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 567 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 626
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 627 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 686
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 687 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 746
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 747 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 804
Score = 127 bits (320), Expect = 4e-29
Identities = 70/202 (34%), Positives = 116/202 (57%), Gaps = 12/202 (5%)
Query: 157 GIPGDEQAENKEDDQ---AGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGV 213
G E+AE+ E + A G + GV + C+ NI+GV+LF+RL+W+VG AG+ +
Sbjct: 97 GAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQAL 156
Query: 214 LIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVA 273
LI+L+ T +T +S SAIATNG V GG+Y++ISRSLGPEFGG++GL F A A
Sbjct: 157 LIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAA 216
Query: 274 MYVVGFAETVVDLLKESDSMMVD---------PTNDIRIIGSITVVILLGISVAGMEWEA 324
MY++G E ++ + ++ N++R+ G+I + + + G+++
Sbjct: 217 MYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVN 276
Query: 325 KAQVILLVILLIAIANFFIGTV 346
K + L ++I+I + + G +
Sbjct: 277 KFASLFLACVIISILSIYAGGI 298
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/246 (26%), Positives = 117/246 (47%), Gaps = 57/246 (23%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKI--NRIEEEKIVMASLLSK 965
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ ++ N I+ +K +A L
Sbjct: 845 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKD-LAVFLYH 903
Query: 966 FRIKFADIHII----GDINIRPNKESWKVFE--EMIEPYRLHESCKDLT----------- 1008
R++ A++ ++ DI+ + + + + +M+ RL ++ ++
Sbjct: 904 LRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 962
Query: 1009 ------------------------TAEKLKRETPWKITDA-----ELEAVK------EKS 1033
T +K ET W + A EL +K +
Sbjct: 963 RLESLYSDEEDESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRM 1021
Query: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKN 1093
+ V+LNE++ S A L++L++P + S D YM +LE+LT+ L VLLVRG +
Sbjct: 1022 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE 1081
Query: 1094 VLTFYS 1099
V+T YS
Sbjct: 1082 VITIYS 1087
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 479
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ N V ++ +
Sbjct: 480 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 506
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 507 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 564
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 565 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 624
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 625 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 684
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 685 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 744
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 745 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 802
Score = 132 bits (331), Expect = 2e-30
Identities = 91/295 (30%), Positives = 150/295 (50%), Gaps = 33/295 (11%)
Query: 70 YDN-----FLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYY-RNTGSISG 123
YDN ++ GE A+ D S D H N F + ++A I+YY RN
Sbjct: 17 YDNLEGLSWVDYGERAELDDS----DGHGNHRESSPF-LSPLEASRGIDYYDRNLALFEE 71
Query: 124 PKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQ---AGVVKFGWV 180
RP + + +L +T + + E+AE+ E + A G +
Sbjct: 72 ELDIRPKVSSLLGKLVSYTNLTQGAKEH----------EEAESGEGTRRRAAEAPSMGTL 121
Query: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR 240
GV + C+ NI+GV+LF+RL+W+VG AG+ +LI+L+ T +T +S SAIATNG V
Sbjct: 122 MGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVP 181
Query: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVD---- 296
GG+Y++ISRSLGPEFGG++GL F A AMY++G E ++ + ++
Sbjct: 182 AGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAH 241
Query: 297 -----PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTV 346
N++R+ G+I + + + G+++ K + L ++I+I + + G +
Sbjct: 242 DTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGI 296
Score = 77.4 bits (189), Expect = 7e-14
Identities = 66/239 (27%), Positives = 112/239 (46%), Gaps = 49/239 (20%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKIN----------------- 950
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ +++
Sbjct: 843 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHL 902
Query: 951 RIE------------EEKIVM---ASLLSKFRI----KFADIHIIGDINIRPNKESWKVF 991
R+E E ++M + +L + R+ + + ++ D + ES
Sbjct: 903 RLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSD 962
Query: 992 EEMIEPYRLHESCKDLTTAEKLKRETPWKITDA-----ELEAVK------EKSYRQVRLN 1040
EE E + + T +K ET W + A EL +K + + V+LN
Sbjct: 963 EED-ESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN 1020
Query: 1041 ELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
E++ S A L++L++P + S D YM +LE+LT+ L VLLVRG + V+T YS
Sbjct: 1021 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 479
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ N V ++ +
Sbjct: 480 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 506
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 507 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 564
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 565 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 624
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 625 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 684
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 685 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 744
Query: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 745 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 802
Score = 132 bits (331), Expect = 2e-30
Identities = 91/295 (30%), Positives = 150/295 (50%), Gaps = 33/295 (11%)
Query: 70 YDN-----FLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYY-RNTGSISG 123
YDN ++ GE A+ D S D H N F + ++A I+YY RN
Sbjct: 17 YDNLEGLSWVDYGERAELDDS----DGHGNHRESSPF-LSPLEASRGIDYYDRNLALFEE 71
Query: 124 PKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQ---AGVVKFGWV 180
RP + + +L +T + + E+AE+ E + A G +
Sbjct: 72 ELDIRPKVSSLLGKLVSYTNLTQGAKEH----------EEAESGEGTRRRAAEAPSMGTL 121
Query: 181 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVR 240
GV + C+ NI+GV+LF+RL+W+VG AG+ +LI+L+ T +T +S SAIATNG V
Sbjct: 122 MGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVP 181
Query: 241 GGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVD---- 296
GG+Y++ISRSLGPEFGG++GL F A AMY++G E ++ + ++
Sbjct: 182 AGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAH 241
Query: 297 -----PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTV 346
N++R+ G+I + + + G+++ K + L ++I+I + + G +
Sbjct: 242 DTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGI 296
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/246 (26%), Positives = 117/246 (47%), Gaps = 57/246 (23%)
Query: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKI--NRIEEEKIVMASLLSK 965
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ ++ N I+ +K +A L
Sbjct: 843 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKD-LAVFLYH 901
Query: 966 FRIKFADIHII----GDINIRPNKESWKVFE--EMIEPYRLHESCKDLT----------- 1008
R++ A++ ++ DI+ + + + + +M+ RL ++ ++
Sbjct: 902 LRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 960
Query: 1009 ------------------------TAEKLKRETPWKITDA-----ELEAVK------EKS 1033
T +K ET W + A EL +K +
Sbjct: 961 RLESLYSDEEDESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRM 1019
Query: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKN 1093
+ V+LNE++ S A L++L++P + S D YM +LE+LT+ L VLLVRG +
Sbjct: 1020 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE 1079
Query: 1094 VLTFYS 1099
V+T YS
Sbjct: 1080 VITIYS 1085
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 470 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 529
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ G +S S + +
Sbjct: 530 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 556
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 557 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 614
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 615 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 674
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 675 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 734
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 735 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 791
Query: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 792 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 851
Query: 788 A 788
+
Sbjct: 852 S 852
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 101 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 159
Query: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 160 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 219
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 220 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 279
Query: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 280 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 335
Query: 334 LLIAIANFFIGTV 346
++++I + G +
Sbjct: 336 VIVSILAIYAGAI 348
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 863 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 922
Query: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 923 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 980
Query: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 981 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1040
Query: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
+ V+LNE++ S A L++L++P +
Sbjct: 1041 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1100
Query: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1101 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1135
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 476 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 535
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ G +S S + +
Sbjct: 536 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 562
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 563 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 620
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 621 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 680
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 681 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 740
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 741 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 797
Query: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 798 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 857
Query: 788 A 788
+
Sbjct: 858 S 858
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 107 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 165
Query: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 166 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 225
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 226 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 285
Query: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 286 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 341
Query: 334 LLIAIANFFIGTV 346
++++I + G +
Sbjct: 342 VIVSILAIYAGAI 354
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 869 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 928
Query: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 929 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 986
Query: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 987 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1046
Query: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
+ V+LNE++ S A L++L++P +
Sbjct: 1047 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1106
Query: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1107 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 426 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 485
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ G +S S + +
Sbjct: 486 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 512
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 513 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 570
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 571 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 630
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 631 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 690
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 691 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 747
Query: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 748 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 807
Query: 788 A 788
+
Sbjct: 808 S 808
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 57 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 115
Query: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 116 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 175
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 176 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 235
Query: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 236 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 291
Query: 334 LLIAIANFFIGTV 346
++++I + G +
Sbjct: 292 VIVSILAIYAGAI 304
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 819 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 878
Query: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 879 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 936
Query: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 937 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 996
Query: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
+ V+LNE++ S A L++L++P +
Sbjct: 997 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1056
Query: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1057 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 426 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 485
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ G +S S + +
Sbjct: 486 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 512
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 513 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 570
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 571 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 630
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 631 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 690
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 691 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 747
Query: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 748 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 807
Query: 788 A 788
+
Sbjct: 808 S 808
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 57 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 115
Query: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 116 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 175
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 176 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 235
Query: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 236 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 291
Query: 334 LLIAIANFFIGTV 346
++++I + G +
Sbjct: 292 VIVSILAIYAGAI 304
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 819 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 878
Query: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 879 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 936
Query: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 937 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 996
Query: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
+ V+LNE++ S A L++L++P +
Sbjct: 997 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1056
Query: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1057 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 434 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 493
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ G +S S + +
Sbjct: 494 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 520
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 521 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 578
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 579 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 638
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 639 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 698
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 699 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 755
Query: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 756 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 815
Query: 788 A 788
+
Sbjct: 816 S 816
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 65 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 123
Query: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 124 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 183
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 184 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 243
Query: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 244 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 299
Query: 334 LLIAIANFFIGTV 346
++++I + G +
Sbjct: 300 VIVSILAIYAGAI 312
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 827 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 886
Query: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 887 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 944
Query: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 945 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1004
Query: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
+ V+LNE++ S A L++L++P +
Sbjct: 1005 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1064
Query: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1065 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1099
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 485 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 544
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
V+RD G+ G+ G +S S + +
Sbjct: 545 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 571
Query: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 572 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 629
Query: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 630 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 689
Query: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 690 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 749
Query: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 750 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 806
Query: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 807 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 866
Query: 788 A 788
+
Sbjct: 867 S 867
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 116 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 174
Query: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 175 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 234
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 235 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 294
Query: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 295 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 350
Query: 334 LLIAIANFFIGTV 346
++++I + G +
Sbjct: 351 VIVSILAIYAGAI 363
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 878 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 937
Query: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 938 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 995
Query: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 996 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1055
Query: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
+ V+LNE++ S A L++L++P +
Sbjct: 1056 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1115
Query: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1116 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 208 bits (529), Expect = 3e-53
Identities = 142/457 (31%), Positives = 221/457 (48%), Gaps = 51/457 (11%)
Query: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
F + I+FP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 420 FTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEG 479
Query: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGP- 494
V+RD G L N V+ M++ P
Sbjct: 480 VVLRDKFGE---------------------------------ALQGNL-VIGMLAWPSPW 505
Query: 495 LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFL 553
+I G F +T + L SL AP++ QA+ +D I LQ F G+GK N EP +LT L
Sbjct: 506 VIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVF--GHGKANGEPTWALLLTVL 563
Query: 554 IAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGA 613
I ILIA L+++API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 564 ICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGM 623
Query: 614 VLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTV 673
LC A+MF+ +W+ A+ +I +Y Y+ + + WG + LS +A L +
Sbjct: 624 SLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHG 683
Query: 674 EDHVKNFRPQCIVLTG----GPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMN 729
H KN+RPQ +V+ + P LL T GL I V G K M
Sbjct: 684 PPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEG--TYLDKHME 741
Query: 730 SGMAKK--QAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
+ A++ ++ + K K F V + RDG+ L+Q++GLG +K NT+++ + +W++
Sbjct: 742 AQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQ 801
Query: 788 APLT-EIENYVGIIHDAFDFEIGVVIVRISQGFDISQ 823
+N+V + D +++ + F +Q
Sbjct: 802 EDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQ 838
Score = 129 bits (324), Expect = 2e-29
Identities = 78/249 (31%), Positives = 133/249 (53%), Gaps = 20/249 (8%)
Query: 117 NTGSISGPKVNRPSLLE------IHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAEN 166
N+ ++ +V + S E E++ N V+ S +++AN G+ E+ E
Sbjct: 49 NSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVS-SLLNKLANYTNLSQGVVEHEEDEE 107
Query: 167 KEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
+A + G GV + C+ NI GV+LF+RL+WIVG AG+ LI+ + T +T
Sbjct: 108 SRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLT 167
Query: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDL 286
+S SAIATNG V GG+YY+ISRSLGPEFGG++GL F A AMY++G E +
Sbjct: 168 AISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTY 227
Query: 287 LKESDSMM---------VDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIA 337
+ ++ +++R+ G+ T+V++ + G+++ K ++ L ++++
Sbjct: 228 ISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLS 287
Query: 338 IANFFIGTV 346
I + G +
Sbjct: 288 ILAIYAGVI 296
Score = 80.5 bits (197), Expect = 8e-15
Identities = 67/274 (24%), Positives = 121/274 (44%), Gaps = 57/274 (20%)
Query: 879 SINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKD 938
++ + + H K V++ Q +++ G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 814 TVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRK 873
Query: 939 CKLRIYVGGKINRIEEEKIVMASLLSKF----RIKFADIHII----GDIN---------I 981
C++RI+ + ++++ I M L F RI A++ ++ DI+ +
Sbjct: 874 CRMRIFT---VAQVDDNSIQMKKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMM 929
Query: 982 RPNKESWKVF-----EEMIEPYRLHESCKDLTTAEKLKRETP------------------ 1018
+ K E+ E +H+ TA + + P
Sbjct: 930 EQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAE 989
Query: 1019 -WKITDAELEAVKE------------KSYRQVRLNELLQEHSRAANLIVLSLPVARKGSI 1065
++ D L K+ + + V+LN ++ S+ A L++L++P K
Sbjct: 990 KYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQ 1049
Query: 1066 SDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
D YM +LE+LT+ L VLLVRG + V+T YS
Sbjct: 1050 GDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 46.2 bits (108), Expect = 2e-04
Identities = 62/294 (21%), Positives = 110/294 (37%), Gaps = 50/294 (17%)
Query: 303 IIGSITVVILLGISVAGMEWEAKAQVI-----LLVILLIAIANFFIGTVIPSNNEKKSRG 357
I I ++IL G+ G++ A I +LV+ I ++ F G+V N +
Sbjct: 166 IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSV--KNWQLTEED 223
Query: 358 FFNYQASIFAENFGPRFTKGEGFFSVF---------AIFFPAATGILAGANISGDLEDPQ 408
F N + N G G F F A F A G A ++++PQ
Sbjct: 224 FGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQ 283
Query: 409 DAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFS 468
AIP G + ++ I +AY GV+ + T++ C + + L F
Sbjct: 284 KAIPVGIVASLLICFIAYFGVSAAL--------------TLMMPYFCLDNNS-PLPDAFK 328
Query: 469 RCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIY 528
E +Y + G A +S L S+ P+V A+ +D +
Sbjct: 329 HVGWEGAKYA-----------------VAVGSLCALSASLLGSMFPMPRVIYAMAEDGL- 370
Query: 529 KALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALI 582
+F A + P+ + + +A + +L + ++S L +Y+L+
Sbjct: 371 -LFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLV 423
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 44.3 bits (103), Expect = 6e-04
Identities = 55/281 (19%), Positives = 117/281 (41%), Gaps = 31/281 (11%)
Query: 160 GDEQAENKEDDQAGVVKFGWVKGVLVRCML---NIWGVMLFIRLSWIVGEAG-IGLGVLI 215
G+ A + G V G++ C + NI G +F+ ++ AG +GL +++
Sbjct: 19 GESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIV 78
Query: 216 ILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAV--- 272
+++ +T + L + + + GG Y + FGG G + + + +
Sbjct: 79 WIVTGFITVVGALCYAELGVT-IPKSGGDYSYVKDI----FGGLAGFLRLWIAVLVIYPT 133
Query: 273 --AMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVIL 330
A+ + F+ V+ L + P + +R++ +I +++L ++ + + W + Q I
Sbjct: 134 NQAVIALTFSNYVLQPLFPT---CFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190
Query: 331 LVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPA 390
L+A+A I ++ + +F + ENF E + A+ F
Sbjct: 191 TAGKLLALALIIIMGIVQICKGE----YFWLEPKNAFENFQ------EPDIGLVALAFLQ 240
Query: 391 ATGILAGAN----ISGDLEDPQDAIPRGTMLAIFITTVAYL 427
+ G N ++ +L DP +PR ++I + T Y+
Sbjct: 241 GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYV 281
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 42.7 bits (99), Expect = 0.002
Identities = 64/290 (22%), Positives = 105/290 (36%), Gaps = 63/290 (21%)
Query: 312 LLGISVAGMEWEAKA--QVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAEN 369
LL V W K V +LV+L + +A F G V N K S F +I A
Sbjct: 219 LLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVA---NWKISEEFLK---NISASA 272
Query: 370 FGPRFTKGEGFFSVFAIFFPAATGILAGA--------------NISGDLEDPQDAIPRGT 415
P G + TG LAGA ++ +PQ AIP G
Sbjct: 273 REPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGI 332
Query: 416 MLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPC 475
+ ++ + +AY GV SAA L + +
Sbjct: 333 VTSLLVCFMAYFGV----------------------------SAALTLMMPYYLLDEK-- 362
Query: 476 QYGLMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQ 532
+ V G+GP ++ AG A +S L S+ P++ A+ +D + +
Sbjct: 363 -----SPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGL--LFR 415
Query: 533 FFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALI 582
F A+ K P+ + +I+ + +L + ++S L +Y+L+
Sbjct: 416 FLAR-VSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLV 464
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 42.4 bits (98), Expect = 0.002
Identities = 66/291 (22%), Positives = 106/291 (36%), Gaps = 64/291 (21%)
Query: 312 LLGISVAGMEWEAKA--QVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAEN 369
LL V W K V +LV+L + +A F G V N K S F +I A
Sbjct: 179 LLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVA---NWKISEEFLK---NISASA 232
Query: 370 FGPRFTKGEGFFSVFAIFFPAATGILAGA--------------NISGDLEDPQDAIPRGT 415
P G + TG LAGA ++ +PQ AIP G
Sbjct: 233 REPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGI 292
Query: 416 MLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPC 475
+ ++ + +AY GV SAA L + +
Sbjct: 293 VTSLLVCFMAYFGV----------------------------SAALTLMMPYYLLDEK-- 322
Query: 476 QYGLMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDN-IYKAL 531
+ V G+GP ++ AG A +S L S+ P+V A+ +D ++K L
Sbjct: 323 -----SPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCL 377
Query: 532 QFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALI 582
A+ K P+ + + +A + +L + ++S L +Y+L+
Sbjct: 378 ---AQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLV 425
>gi|71999149 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 13 [Homo sapiens]
Length = 470
Score = 38.9 bits (89), Expect = 0.027
Identities = 54/245 (22%), Positives = 90/245 (36%), Gaps = 10/245 (4%)
Query: 188 MLNIWGVMLFIRLSWIVGEAGIGLGV-LIILLSTMVTSITGLSTSAIATNGFVRGGGAYY 246
++NI G +F+ ++ + + +GV L + + ++T SA + F G YY
Sbjct: 23 LINIIGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYY 82
Query: 247 LISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGS 306
+ R G F + VA + AE + S S+ P + +
Sbjct: 83 FLKRYFGSTVAFLNLWTSLFLGSGVVAGQALLLAEYSIQPFFPSCSVPKLPKKCLALAML 142
Query: 307 ITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIF 366
V IL V + W A +L V +L I+ + +I E R F
Sbjct: 143 WIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVER---------F 193
Query: 367 AENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAY 426
F + A +G I+G+L+ P+ IP+ A+ + TV Y
Sbjct: 194 QNAFDAELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVY 253
Query: 427 LGVAI 431
L V I
Sbjct: 254 LLVNI 258
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 37.7 bits (86), Expect = 0.060
Identities = 56/288 (19%), Positives = 114/288 (39%), Gaps = 51/288 (17%)
Query: 307 ITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIF 366
+T ++ LG S + + + V LLV+ + I+ F G V +N K + + +
Sbjct: 175 LTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDV---HNWKLTEEDYELAMAEL 231
Query: 367 AENF--GPRFTKG------EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 418
+ + GP + G EG A F A G A + ++PQ +IP G +++
Sbjct: 232 NDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVIS 291
Query: 419 IFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYG 478
+ + +AY V S+A L + + + E
Sbjct: 292 LSVCFLAYFAV----------------------------SSALTLMMPYYQLQPE----- 318
Query: 479 LMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535
+ + G+ P ++ G A +S L S+ P+V A+ +D + + A
Sbjct: 319 --SPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL--LFRVLA 374
Query: 536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALIN 583
+ + P+ +++ +IA + +L + ++S L +Y+L++
Sbjct: 375 RIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVS 422
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 37.7 bits (86), Expect = 0.060
Identities = 56/288 (19%), Positives = 114/288 (39%), Gaps = 51/288 (17%)
Query: 307 ITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIF 366
+T ++ LG S + + + V LLV+ + I+ F G V +N K + + +
Sbjct: 175 LTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDV---HNWKLTEEDYELAMAEL 231
Query: 367 AENF--GPRFTKG------EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 418
+ + GP + G EG A F A G A + ++PQ +IP G +++
Sbjct: 232 NDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVIS 291
Query: 419 IFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYG 478
+ + +AY V S+A L + + + E
Sbjct: 292 LSVCFLAYFAV----------------------------SSALTLMMPYYQLQPE----- 318
Query: 479 LMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535
+ + G+ P ++ G A +S L S+ P+V A+ +D + + A
Sbjct: 319 --SPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL--LFRVLA 374
Query: 536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALIN 583
+ + P+ +++ +IA + +L + ++S L +Y+L++
Sbjct: 375 RIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVS 422
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 36.6 bits (83), Expect = 0.13
Identities = 54/276 (19%), Positives = 106/276 (38%), Gaps = 33/276 (11%)
Query: 159 PGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAG-IGLGVLIIL 217
PG E+ + K K ++GV + + I G +FI ++ G +G+ + I
Sbjct: 33 PGQEKVQLKR-------KVTLLRGVSI-IIGTIIGAGIFISPKGVLQNTGSVGMSLTIWT 84
Query: 218 LSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVV 277
+ +++ LS + + T + GG Y I GP + AF + +
Sbjct: 85 VCGVLSLFGALSYAELGTT-IKKSGGHYTYILEVFGP--------LPAFVRVWVELLIIR 135
Query: 278 GFAETVVDL------LKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILL 331
A V+ L L+ P I++I ++ + +++ ++ + W A+ Q+ L
Sbjct: 136 PAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLT 195
Query: 332 VILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAA 391
L AI + V+ Q F + F R + F A
Sbjct: 196 FCKLTAILIIIVPGVMQ---------LIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAY 246
Query: 392 TGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYL 427
G ++ ++E+P+ IP +++ I T+ Y+
Sbjct: 247 AGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYV 282
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 33.5 bits (75), Expect = 1.1
Identities = 34/166 (20%), Positives = 73/166 (43%), Gaps = 15/166 (9%)
Query: 182 GVLVRCML---NIWGVMLFIRLSWIVGEAG-IGLGVLIILLSTMVTSITGLSTSAIATNG 237
G+L C + NI G +FI ++ +G +GL + + +L VT++ L + +
Sbjct: 41 GLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGV-A 99
Query: 238 FVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVD----LLKESDSM 293
+ GG Y ++ FGG G + ++ + MY A + +L+
Sbjct: 100 IPKSGGDYAYVTEI----FGGLAGFLLLWS--AVLIMYPTSLAVISMTFSNYVLQPVFPN 153
Query: 294 MVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIA 339
+ PT R++ +++L ++ + + W + Q + L+A++
Sbjct: 154 CIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALS 199
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,806,223
Number of Sequences: 37866
Number of extensions: 1654651
Number of successful extensions: 4504
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 4360
Number of HSP's gapped (non-prelim): 118
length of query: 1099
length of database: 18,247,518
effective HSP length: 113
effective length of query: 986
effective length of database: 13,968,660
effective search space: 13773098760
effective search space used: 13773098760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.