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Search of human proteins with 55956904
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55956904 mitogen-activated protein kinase kinase kinase 4
isoform a [Homo sapiens]
(1608 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 3243 0.0
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 3103 0.0
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 198 3e-50
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 198 3e-50
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 186 2e-46
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 171 5e-42
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 171 5e-42
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 164 6e-40
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 163 1e-39
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 162 2e-39
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 160 7e-39
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 155 4e-37
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 155 4e-37
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 155 4e-37
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 155 4e-37
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 155 4e-37
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 155 4e-37
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 155 4e-37
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 154 5e-37
gi|32483399 p21-activated kinase 2 [Homo sapiens] 154 9e-37
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 149 2e-35
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 149 2e-35
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 148 4e-35
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 146 1e-34
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 145 2e-34
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 144 9e-34
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 144 9e-34
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 138 5e-32
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 137 8e-32
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 137 8e-32
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 3243 bits (8408), Expect = 0.0
Identities = 1608/1608 (100%), Positives = 1608/1608 (100%)
Query: 1 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 60
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
Sbjct: 1 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 60
Query: 61 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 120
CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
Sbjct: 61 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 120
Query: 121 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 180
NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
Sbjct: 121 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 180
Query: 181 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 240
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
Sbjct: 181 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 240
Query: 241 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 300
KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
Sbjct: 241 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 300
Query: 301 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 360
FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
Sbjct: 301 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 360
Query: 361 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 420
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
Sbjct: 361 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 420
Query: 421 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 480
DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
Sbjct: 421 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 480
Query: 481 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 540
SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
Sbjct: 481 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 540
Query: 541 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 600
KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
Sbjct: 541 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 600
Query: 601 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 660
WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
Sbjct: 601 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 660
Query: 661 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 720
GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
Sbjct: 661 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 720
Query: 721 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 780
SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
Sbjct: 721 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 780
Query: 781 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 840
ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
Sbjct: 781 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 840
Query: 841 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 900
LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
Sbjct: 841 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 900
Query: 901 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 960
LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
Sbjct: 901 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 960
Query: 961 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 1020
AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
Sbjct: 961 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 1020
Query: 1021 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1080
DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
Sbjct: 1021 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1080
Query: 1081 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1140
CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
Sbjct: 1081 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1140
Query: 1141 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1200
YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
Sbjct: 1141 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1200
Query: 1201 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1260
AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
Sbjct: 1201 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1260
Query: 1261 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1320
AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
Sbjct: 1261 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1320
Query: 1321 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1380
VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
Sbjct: 1321 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1380
Query: 1381 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1440
HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
Sbjct: 1381 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1440
Query: 1441 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1500
RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
Sbjct: 1441 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1500
Query: 1501 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1560
STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
Sbjct: 1501 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1560
Query: 1561 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1608
GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
Sbjct: 1561 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1608
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 3103 bits (8045), Expect = 0.0
Identities = 1548/1608 (96%), Positives = 1552/1608 (96%), Gaps = 50/1608 (3%)
Query: 1 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 60
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
Sbjct: 1 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 60
Query: 61 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 120
CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
Sbjct: 61 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 120
Query: 121 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 180
NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP
Sbjct: 121 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 180
Query: 181 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 240
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
Sbjct: 181 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 240
Query: 241 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 300
KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
Sbjct: 241 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 300
Query: 301 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 360
FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
Sbjct: 301 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 360
Query: 361 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 420
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
Sbjct: 361 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 420
Query: 421 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 480
DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
Sbjct: 421 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 480
Query: 481 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 540
SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
Sbjct: 481 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 540
Query: 541 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 600
KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
Sbjct: 541 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 600
Query: 601 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 660
WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
Sbjct: 601 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 660
Query: 661 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 720
GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
Sbjct: 661 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 720
Query: 721 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 780
SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
Sbjct: 721 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 780
Query: 781 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 840
ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
Sbjct: 781 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 840
Query: 841 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 900
LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
Sbjct: 841 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 900
Query: 901 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 960
LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
Sbjct: 901 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 960
Query: 961 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 1020
AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
Sbjct: 961 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 1020
Query: 1021 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1080
DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
Sbjct: 1021 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1080
Query: 1081 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1140
CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
Sbjct: 1081 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1140
Query: 1141 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1200
YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF S+P + R A++
Sbjct: 1141 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDR------------LASI 1188
Query: 1201 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1260
AA ELQFRSLSRHSSPTEERDEP
Sbjct: 1189 AA--------------------------------------ELQFRSLSRHSSPTEERDEP 1210
Query: 1261 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1320
AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
Sbjct: 1211 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1270
Query: 1321 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1380
VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
Sbjct: 1271 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1330
Query: 1381 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1440
HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
Sbjct: 1331 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1390
Query: 1441 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1500
RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
Sbjct: 1391 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1450
Query: 1501 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1560
STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
Sbjct: 1451 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1510
Query: 1561 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1608
GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
Sbjct: 1511 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1558
>gi|42794767 mitogen-activated protein kinase kinase kinase 3 isoform
1 [Homo sapiens]
Length = 657
Score = 198 bits (504), Expect = 3e-50
Identities = 149/510 (29%), Positives = 236/510 (46%), Gaps = 32/510 (6%)
Query: 1121 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP 1180
L+++ H PHS V+ S + +P + HL + + + P
Sbjct: 151 LLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPP 210
Query: 1181 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA 1240
A + + + P + + +SSA ++ S DR A +
Sbjct: 211 GYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPS 270
Query: 1241 ELQFRSLSRHSSPTE-----ERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE 1295
+ R S P +R+ Y +G G+ R + + D I
Sbjct: 271 FRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIR 330
Query: 1296 AIQKSV-RLFEEKRYREMRRKN--IIGQVCDT-----PKSYDNVMHVGLRKVTFK----- 1342
Q ++ L R +N + Q D +N + V R V K
Sbjct: 331 RHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAP 390
Query: 1343 --WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGI 1397
W+RG +G+G +G+VY C VDTG +A K+++F P+ +T KE + E+++ + +
Sbjct: 391 INWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL 450
Query: 1398 KHPNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINV 1453
+H +V+Y+G R E + IFMEY G++++ + L E V R Y++QI ++
Sbjct: 451 QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSY 510
Query: 1454 LHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEV 1513
LH + IVHRDIKGANI S+G +KLGDFG S +L+ + G + S GT +M+PEV
Sbjct: 511 LHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEV 569
Query: 1514 ITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPE 1573
I+ GEG+GR AD+WSLGC V+EM+T K PW EYE I P +P +S
Sbjct: 570 IS---GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEH 626
Query: 1574 GKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603
G+DFL + + + R +A +LL H F ++
Sbjct: 627 GRDFLRR-IFVEARQRPSAEELLTHHFAQL 655
>gi|42794765 mitogen-activated protein kinase kinase kinase 3 isoform
2 [Homo sapiens]
Length = 626
Score = 198 bits (504), Expect = 3e-50
Identities = 149/510 (29%), Positives = 236/510 (46%), Gaps = 32/510 (6%)
Query: 1121 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP 1180
L+++ H PHS V+ S + +P + HL + + + P
Sbjct: 120 LLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPP 179
Query: 1181 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA 1240
A + + + P + + +SSA ++ S DR A +
Sbjct: 180 GYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPS 239
Query: 1241 ELQFRSLSRHSSPTE-----ERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE 1295
+ R S P +R+ Y +G G+ R + + D I
Sbjct: 240 FRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIR 299
Query: 1296 AIQKSV-RLFEEKRYREMRRKN--IIGQVCDT-----PKSYDNVMHVGLRKVTFK----- 1342
Q ++ L R +N + Q D +N + V R V K
Sbjct: 300 RHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAP 359
Query: 1343 --WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGI 1397
W+RG +G+G +G+VY C VDTG +A K+++F P+ +T KE + E+++ + +
Sbjct: 360 INWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL 419
Query: 1398 KHPNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINV 1453
+H +V+Y+G R E + IFMEY G++++ + L E V R Y++QI ++
Sbjct: 420 QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSY 479
Query: 1454 LHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEV 1513
LH + IVHRDIKGANI S+G +KLGDFG S +L+ + G + S GT +M+PEV
Sbjct: 480 LHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEV 538
Query: 1514 ITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPE 1573
I+ GEG+GR AD+WSLGC V+EM+T K PW EYE I P +P +S
Sbjct: 539 IS---GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEH 595
Query: 1574 GKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603
G+DFL + + + R +A +LL H F ++
Sbjct: 596 GRDFLRR-IFVEARQRPSAEELLTHHFAQL 624
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 186 bits (472), Expect = 2e-46
Identities = 105/266 (39%), Positives = 160/266 (60%), Gaps = 12/266 (4%)
Query: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKH 1399
W+ G +G+G +G+VY C VDTG +A+K+++F P+ +T KE E+++ + + H
Sbjct: 356 WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH 415
Query: 1400 PNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLH 1455
+V+Y+G +E + IFMEY G++++ + L E+V R Y++QI ++ LH
Sbjct: 416 ERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH 475
Query: 1456 EHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT 1515
+ IVHRDIKGANI S+G +KLGDFG S +L+ + G + S GT +M+PEVI+
Sbjct: 476 SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG-MKSVTGTPYWMSPEVIS 534
Query: 1516 RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGK 1575
GEG+GR ADIWS+ C V+EM+T K PW E+E I P +P +S +
Sbjct: 535 ---GEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTR 591
Query: 1576 DFLSHCLESDPKMRWTASQLLDHSFV 1601
DFL + + K+R +A +LL H FV
Sbjct: 592 DFLKR-IFVEAKLRPSADELLRHMFV 616
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 171 bits (433), Expect = 5e-42
Identities = 103/270 (38%), Positives = 151/270 (55%), Gaps = 15/270 (5%)
Query: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND----HKTIKETADELKIFEGIK 1398
W +G +G+G YG VY C G+L+A+K++ ++ K ++ +E+ + + +K
Sbjct: 1061 WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALK 1119
Query: 1399 HPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLHE 1456
H N+V Y G L + IFME+ G++ + +R G L E V Y+KQI + LHE
Sbjct: 1120 HVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE 1179
Query: 1457 HGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL--KNNAQTMPGEVNSTLGTAAYMAPEVI 1514
+ +VHRDIKG N+ L +G+IKL DFGC+ +L T + S GT +MAPEVI
Sbjct: 1180 NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI 1239
Query: 1515 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG--MGHKPPIPERLSP 1572
+ G+GR +DIWS+GC V EM TGK P + M+ +G G PP+P+ S
Sbjct: 1240 NES---GYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLMPPLPDHFSE 1295
Query: 1573 EGKDFLSHCLESDPKMRWTASQLLDHSFVK 1602
DF+ CL D R +A QLL HSF++
Sbjct: 1296 NAADFVRMCLTRDQHERPSALQLLKHSFLE 1325
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 171 bits (433), Expect = 5e-42
Identities = 103/270 (38%), Positives = 151/270 (55%), Gaps = 15/270 (5%)
Query: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND----HKTIKETADELKIFEGIK 1398
W +G +G+G YG VY C G+L+A+K++ ++ K ++ +E+ + + +K
Sbjct: 243 WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALK 301
Query: 1399 HPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLHE 1456
H N+V Y G L + IFME+ G++ + +R G L E V Y+KQI + LHE
Sbjct: 302 HVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE 361
Query: 1457 HGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL--KNNAQTMPGEVNSTLGTAAYMAPEVI 1514
+ +VHRDIKG N+ L +G+IKL DFGC+ +L T + S GT +MAPEVI
Sbjct: 362 NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI 421
Query: 1515 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG--MGHKPPIPERLSP 1572
+ G+GR +DIWS+GC V EM TGK P + M+ +G G PP+P+ S
Sbjct: 422 NES---GYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLMPPLPDHFSE 477
Query: 1573 EGKDFLSHCLESDPKMRWTASQLLDHSFVK 1602
DF+ CL D R +A QLL HSF++
Sbjct: 478 NAADFVRMCLTRDQHERPSALQLLKHSFLE 507
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 164 bits (415), Expect = 6e-40
Identities = 106/267 (39%), Positives = 148/267 (55%), Gaps = 14/267 (5%)
Query: 1349 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1408
+G+G YG VY + +A+KEI D + + +E+ + + +KH N+V+Y G
Sbjct: 686 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 743
Query: 1409 ELHREEMYIFMEYCDEGTLEEVSR-----LGLQEHVIRLYSKQITIAINVLHEHGIVHRD 1463
+ IFME G+L + R L E I Y+KQI + LH++ IVHRD
Sbjct: 744 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 803
Query: 1464 IKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGH 1522
IKG N+ + T SG++K+ DFG S +L A P T GT YMAPE+I + G+
Sbjct: 804 IKGDNVLINTYSGVLKISDFGTSKRL---AGINPCTETFT-GTLQYMAPEIIDKGP-RGY 858
Query: 1523 GRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHC 1581
G+AADIWSLGC +IEM TGK P++E M+KVGM P IPE +S E K F+ C
Sbjct: 859 GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKC 918
Query: 1582 LESDPKMRWTASQLLDHSFVKVCTDEE 1608
E DP R A+ LL F+KV + ++
Sbjct: 919 FEPDPDKRACANDLLVDEFLKVSSKKK 945
>gi|121583542 mitogen-activated protein kinase kinase kinase 15 [Homo
sapiens]
Length = 788
Score = 163 bits (412), Expect = 1e-39
Identities = 103/259 (39%), Positives = 144/259 (55%), Gaps = 12/259 (4%)
Query: 1349 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1408
+G+G YG VY + +A+KEI D + + +E+ + + +KH N+V+Y G
Sbjct: 133 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKYLKHRNIVQYLGS 190
Query: 1409 ELHREEMYIFMEYCDEGTLEEVSRLG---LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1465
+ IFME G+L + R ++E I+ Y+KQI + LHE+ IVHRDIK
Sbjct: 191 VSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIK 250
Query: 1466 GANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR 1524
G N+ + T SG++K+ DFG S +L A P T GT YMAPE+I + G+G
Sbjct: 251 GDNVLVNTYSGVVKISDFGTSKRL---AGVNPCTETFT-GTLQYMAPEIIDQGP-RGYGA 305
Query: 1525 AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHCLE 1583
ADIWSLGC +IEM T K P+HE M+KVGM P IPE LS E + F+ C E
Sbjct: 306 PADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFE 365
Query: 1584 SDPKMRWTASQLLDHSFVK 1602
DP R T ++LL F++
Sbjct: 366 PDPHKRATTAELLREGFLR 384
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 162 bits (411), Expect = 2e-39
Identities = 86/267 (32%), Positives = 151/267 (56%), Gaps = 13/267 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN----DHKTIKETADELKIFEGI 1397
+W +G +IG G + Y V TG LMA+K++ + N + ++ +E+++ +
Sbjct: 1242 EWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL 1301
Query: 1398 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLH 1455
HPN++R G + +F+E+ G++ + S+ G +E V+ Y++Q+ ++ LH
Sbjct: 1302 NHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLH 1361
Query: 1456 EHGIVHRDIKGANIFLTSSGL-IKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI 1514
E+ I+HRD+KGAN+ + S+G +++ DFG + +L + LGT A+MAPEV+
Sbjct: 1362 ENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL 1421
Query: 1515 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH--NFQIMYKVGMG-HKPPIPERLS 1571
+G+ +GR+ D+WS+GC +IEM K PW+ +H + +++K+ P IP LS
Sbjct: 1422 ---RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLS 1478
Query: 1572 PEGKDFLSHCLESDPKMRWTASQLLDH 1598
P +D CLE P+ R + +LL H
Sbjct: 1479 PGLRDVALRCLELQPQDRPPSRELLKH 1505
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 160 bits (406), Expect = 7e-39
Identities = 104/261 (39%), Positives = 144/261 (55%), Gaps = 14/261 (5%)
Query: 1349 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1408
+G+G YG VY T +A+KEI D + + +E+ + ++H N+VRY G
Sbjct: 654 LGKGTYGVVYAGRDRHTRVRIAIKEI--PERDSRFSQPLHEEIALHRRLRHKNIVRYLGS 711
Query: 1409 ELHREEMYIFMEYCDEGTLEEVSR-----LGLQEHVIRLYSKQITIAINVLHEHGIVHRD 1463
+ IFME G+L + R L E I Y++QI + LH++ IVHRD
Sbjct: 712 ASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRD 771
Query: 1464 IKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGH 1522
IKG N+ + T SGL+K+ DFG S +L A P T GT YMAPE+I + G+
Sbjct: 772 IKGDNVLINTFSGLLKISDFGTSKRL---AGITPCTETFT-GTLQYMAPEIIDQGP-RGY 826
Query: 1523 GRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHC 1581
G+AADIWSLGC VIEM TG+ P+HE M++VGM PP+P LS E + FL
Sbjct: 827 GKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRT 886
Query: 1582 LESDPKMRWTASQLLDHSFVK 1602
E DP++R +A LL F++
Sbjct: 887 FEPDPRLRASAQTLLGDPFLQ 907
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 155 bits (391), Expect = 4e-37
Identities = 93/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + + TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 339
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A++ LH + ++
Sbjct: 340 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 399
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 400 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 452
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PERLS +DFL
Sbjct: 453 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFL 511
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D R +A +LL H F+K+
Sbjct: 512 NRCLEMDVDRRGSAKELLQHPFLKL 536
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 155 bits (391), Expect = 4e-37
Identities = 93/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + + TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 288 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 345
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A++ LH + ++
Sbjct: 346 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 405
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 406 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 458
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PERLS +DFL
Sbjct: 459 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFL 517
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D R +A +LL H F+K+
Sbjct: 518 NRCLEMDVDRRGSAKELLQHPFLKL 542
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 155 bits (391), Expect = 4e-37
Identities = 93/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + + TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 303 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 360
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A++ LH + ++
Sbjct: 361 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 420
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 421 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 473
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PERLS +DFL
Sbjct: 474 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFL 532
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D R +A +LL H F+K+
Sbjct: 533 NRCLEMDVDRRGSAKELLQHPFLKL 557
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 155 bits (391), Expect = 4e-37
Identities = 93/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + + TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 267 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 324
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A++ LH + ++
Sbjct: 325 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 384
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 385 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 437
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PERLS +DFL
Sbjct: 438 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFL 496
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D R +A +LL H F+K+
Sbjct: 497 NRCLEMDVDRRGSAKELLQHPFLKL 521
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 155 bits (391), Expect = 4e-37
Identities = 93/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + + TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 267 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 324
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A++ LH + ++
Sbjct: 325 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 384
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 385 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 437
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PERLS +DFL
Sbjct: 438 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFL 496
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D R +A +LL H F+K+
Sbjct: 497 NRCLEMDVDRRGSAKELLQHPFLKL 521
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 155 bits (391), Expect = 4e-37
Identities = 93/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + + TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 267 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 324
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A++ LH + ++
Sbjct: 325 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 384
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 385 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 437
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PERLS +DFL
Sbjct: 438 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFL 496
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D R +A +LL H F+K+
Sbjct: 497 NRCLEMDVDRRGSAKELLQHPFLKL 521
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 155 bits (391), Expect = 4e-37
Identities = 99/271 (36%), Positives = 143/271 (52%), Gaps = 20/271 (7%)
Query: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKH 1399
W+ ++G+G +GKVY + +T L A K I D K+ +E D E+ I H
Sbjct: 34 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVI-----DTKSEEELEDYMVEIDILASCDH 88
Query: 1400 PNLVRYFGVELHREEMYIFMEYCDEGTLEEVS---RLGLQEHVIRLYSKQITIAINVLHE 1456
PN+V+ + ++I +E+C G ++ V L E I++ KQ A+N LH+
Sbjct: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
Query: 1457 HGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-- 1514
+ I+HRD+K NI T G IKL DFG S K N +T+ +S +GT +MAPEV+
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAK---NTRTIQRR-DSFIGTPYWMAPEVVMC 204
Query: 1515 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSP 1572
+K + AD+WSLG +IEM + P HE + +++ K+ P + P R S
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL-NPMRVLLKIAKSEPPTLAQPSRWSS 263
Query: 1573 EGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603
KDFL CLE + RWT SQLL H FV V
Sbjct: 264 NFKDFLKKCLEKNVDARWTTSQLLQHPFVTV 294
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 154 bits (390), Expect = 5e-37
Identities = 92/265 (34%), Positives = 147/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + V TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 269 KYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 326
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A+ LH + ++
Sbjct: 327 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI 386
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ ++ +GT +MAPEV+TR +
Sbjct: 387 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR----STMVGTPYWMAPEVVTR---K 439
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEM+ G+ P+ E+ + +Y + P + PE+LS +DFL
Sbjct: 440 AYGPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRALYLIATNGTPELQNPEKLSAIFRDFL 498
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D + R +A +LL H F+K+
Sbjct: 499 NRCLEMDVEKRGSAKELLQHQFLKI 523
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 154 bits (388), Expect = 9e-37
Identities = 91/265 (34%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G V+T V G+ +A+K+I Q K + +E+ + + +K+PN
Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKEL--IINEILVMKELKNPN 305
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V + L +E+++ MEY G+L +V + + E I ++ A+ LH + ++
Sbjct: 306 IVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVI 365
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK N+ L G +KL DFG ++ ++ +GT +MAPEV+TR +
Sbjct: 366 HRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKR----STMVGTPYWMAPEVVTR---K 418
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEMV G+ P+ E+ + +Y + P + PE+LSP +DFL
Sbjct: 419 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPEKLSPIFRDFL 477
Query: 1579 SHCLESDPKMRWTASQLLDHSFVKV 1603
+ CLE D + R +A +LL H F+K+
Sbjct: 478 NRCLEMDVEKRGSAKELLQHPFLKL 502
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 149 bits (377), Expect = 2e-35
Identities = 93/274 (33%), Positives = 152/274 (55%), Gaps = 16/274 (5%)
Query: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNL 1402
W+ ++G+G +GKVY + +TG L A K I + + +++ E++I HP +
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHPYI 93
Query: 1403 VRYFGVELHREEMYIFMEYCDEGTLE----EVSRLGLQEHVIRLYSKQITIAINVLHEHG 1458
V+ G H +++I +E+C G ++ E+ R GL E I++ +Q+ A+N LH
Sbjct: 94 VKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDR-GLTEPQIQVVCRQMLEALNFLHSKR 152
Query: 1459 IVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI--TR 1516
I+HRD+K N+ +T G I+L DFG S K N +T+ + +S +GT +MAPEV+
Sbjct: 153 IIHRDLKAGNVLMTLEGDIRLADFGVSAK---NLKTLQ-KRDSFIGTPYWMAPEVVMCET 208
Query: 1517 AKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEG 1574
K + ADIWSLG +IEM + P HE + +++ K+ P + P + S E
Sbjct: 209 MKDTPYDYKADIWSLGITLIEMAQIEPPHHEL-NPMRVLLKIAKSDPPTLLTPSKWSVEF 267
Query: 1575 KDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1608
+DFL L+ +P+ R +A+QLL+H FV T +
Sbjct: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNK 301
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 149 bits (377), Expect = 2e-35
Identities = 91/260 (35%), Positives = 137/260 (52%), Gaps = 17/260 (6%)
Query: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1407
K+GEG YG VY I +TG+++A+K++ + + + IKE + I + P++V+Y+G
Sbjct: 35 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKE----ISIMQQCDSPHVVKYYG 90
Query: 1408 VELHREEMYIFMEYCDEGTLEEVSRL---GLQEHVIRLYSKQITIAINVLHEHGIVHRDI 1464
+++I MEYC G++ ++ RL L E I + + LH +HRDI
Sbjct: 91 SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDI 150
Query: 1465 KGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR 1524
K NI L + G KL DFG + +L + + N+ +GT +MAPEVI G+
Sbjct: 151 KAGNILLNTEGHAKLADFGVAGQLTDTM----AKRNTVIGTPFWMAPEVIQEI---GYNC 203
Query: 1525 AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFLSHCL 1582
ADIWSLG IEM GK P+ + H + ++ + P PE S DF+ CL
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262
Query: 1583 ESDPKMRWTASQLLDHSFVK 1602
P+ R TA+QLL H FV+
Sbjct: 263 VKSPEQRATATQLLQHPFVR 282
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 148 bits (374), Expect = 4e-35
Identities = 88/259 (33%), Positives = 140/259 (54%), Gaps = 11/259 (4%)
Query: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1407
+IG G YG VY +V+TGEL A+K I+ +P + + + E+ + + KHPN+V YFG
Sbjct: 21 RIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQ--QEIIMMKDCKHPNIVAYFG 78
Query: 1408 VELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1465
L R++++I ME+C G+L+++ + L E I S++ + LH G +HRDIK
Sbjct: 79 SYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIK 138
Query: 1466 GANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRA 1525
GANI LT +G +KL DFG S ++ + S +GT +MAPEV + G+ +
Sbjct: 139 GANILLTDNGHVKLADFGVSAQITATI----AKRKSFIGTPYWMAPEVAAVERKGGYNQL 194
Query: 1526 ADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPP-IPERL--SPEGKDFLSHCL 1582
D+W++G IE+ + P + + +PP + +++ S F+ L
Sbjct: 195 CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMAL 254
Query: 1583 ESDPKMRWTASQLLDHSFV 1601
+PK R TA +LL H FV
Sbjct: 255 TKNPKKRPTAEKLLQHPFV 273
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 146 bits (369), Expect = 1e-34
Identities = 90/260 (34%), Positives = 138/260 (53%), Gaps = 17/260 (6%)
Query: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1407
K+GEG YG V+ I ++G+++A+K++ + + + IKE + I + P +V+Y+G
Sbjct: 32 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKE----ISIMQQCDSPYVVKYYG 87
Query: 1408 VELHREEMYIFMEYCDEGTLEEVSRL---GLQEHVIRLYSKQITIAINVLHEHGIVHRDI 1464
+++I MEYC G++ ++ RL L E I K + LH +HRDI
Sbjct: 88 SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDI 147
Query: 1465 KGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR 1524
K NI L + G KL DFG + +L + + N+ +GT +MAPEVI G+
Sbjct: 148 KAGNILLNTEGHAKLADFGVAGQLTDTM----AKRNTVIGTPFWMAPEVIQEI---GYNC 200
Query: 1525 AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFLSHCL 1582
ADIWSLG IEM GK P+ + H + ++ + P PE S + DF+ CL
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
Query: 1583 ESDPKMRWTASQLLDHSFVK 1602
+P+ R TA+QLL H F+K
Sbjct: 260 VKNPEQRATATQLLQHPFIK 279
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 145 bits (367), Expect = 2e-34
Identities = 89/258 (34%), Positives = 143/258 (55%), Gaps = 13/258 (5%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+ R KIG+G G VYT + V TG+ +A+K++ Q K + +E+ + K+PN
Sbjct: 269 KYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPN 326
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLGLQEHVIRLYSKQITIAINVLHEHGIV 1460
+V Y L +E+++ MEY G+L +V + + E I ++ A+ LH + ++
Sbjct: 327 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI 386
Query: 1461 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1520
HRDIK NI L G +KL DFG ++ + ++ +GT +MAPEV+TR +
Sbjct: 387 HRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMVGTPYWMAPEVVTR---K 439
Query: 1521 GHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFL 1578
+G DIWSLG + IEM+ G+ P+ E+ + +Y + P + PE+LS +DFL
Sbjct: 440 AYGPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRALYLIATNGTPELQNPEKLSAIFRDFL 498
Query: 1579 SHCLESDPKMRWTASQLL 1596
+ CLE D + R +A +LL
Sbjct: 499 NRCLEMDVEKRGSAKELL 516
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 144 bits (362), Expect = 9e-34
Identities = 90/259 (34%), Positives = 136/259 (52%), Gaps = 11/259 (4%)
Query: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1407
++G G YG VY +V TGEL A+K I+ +P D ++ + E+ + + KH N+V YFG
Sbjct: 25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ--QEIFMVKECKHCNIVAYFG 82
Query: 1408 VELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1465
L RE+++I MEYC G+L+++ + L E I ++ + LH G +HRDIK
Sbjct: 83 SYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIK 142
Query: 1466 GANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRA 1525
GANI LT G +KL DFG + K+ + S +GT +MAPEV K G+ +
Sbjct: 143 GANILLTDHGDVKLADFGVAAKITATI----AKRKSFIGTPYWMAPEVAAVEKNGGYNQL 198
Query: 1526 ADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPP---IPERLSPEGKDFLSHCL 1582
DIW++G IE+ + P + + +PP + S +F+ L
Sbjct: 199 CDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIAL 258
Query: 1583 ESDPKMRWTASQLLDHSFV 1601
+PK R TA +LL H+FV
Sbjct: 259 TKNPKKRPTAERLLTHTFV 277
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 144 bits (362), Expect = 9e-34
Identities = 90/259 (34%), Positives = 136/259 (52%), Gaps = 11/259 (4%)
Query: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1407
++G G YG VY +V TGEL A+K I+ +P D ++ + E+ + + KH N+V YFG
Sbjct: 25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ--QEIFMVKECKHCNIVAYFG 82
Query: 1408 VELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1465
L RE+++I MEYC G+L+++ + L E I ++ + LH G +HRDIK
Sbjct: 83 SYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIK 142
Query: 1466 GANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRA 1525
GANI LT G +KL DFG + K+ + S +GT +MAPEV K G+ +
Sbjct: 143 GANILLTDHGDVKLADFGVAAKITATI----AKRKSFIGTPYWMAPEVAAVEKNGGYNQL 198
Query: 1526 ADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPP---IPERLSPEGKDFLSHCL 1582
DIW++G IE+ + P + + +PP + S +F+ L
Sbjct: 199 CDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIAL 258
Query: 1583 ESDPKMRWTASQLLDHSFV 1601
+PK R TA +LL H+FV
Sbjct: 259 TKNPKKRPTAERLLTHTFV 277
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 138 bits (347), Expect = 5e-32
Identities = 84/256 (32%), Positives = 139/256 (54%), Gaps = 10/256 (3%)
Query: 1347 NKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYF 1406
++IG+G +G+VY I T E++A+K I + + + I++ E+ + P + RYF
Sbjct: 24 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYITRYF 82
Query: 1407 GVELHREEMYIFMEYCDEGTLEEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1465
G L +++I MEY G+ ++ + G L+E I ++I ++ LH +HRDIK
Sbjct: 83 GSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIK 142
Query: 1466 GANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRA 1525
AN+ L+ G +KL DFG + +L + + N+ +GT +MAPEVI K +
Sbjct: 143 AANVLLSEQGDVKLADFGVAGQLTDTQI----KRNTFVGTPFWMAPEVI---KQSAYDFK 195
Query: 1526 ADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESD 1585
ADIWSLG IE+ G+ P + H ++++ + P + + S K+F+ CL D
Sbjct: 196 ADIWSLGITAIELAKGEPPNSDL-HPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKD 254
Query: 1586 PKMRWTASQLLDHSFV 1601
P+ R TA +LL H F+
Sbjct: 255 PRFRPTAKELLKHKFI 270
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 137 bits (345), Expect = 8e-32
Identities = 89/291 (30%), Positives = 140/291 (48%), Gaps = 39/291 (13%)
Query: 1342 KWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN 1401
K+++ KIGEG YG V+ C + DTG+++A+K+ +D K E+++ + +KHPN
Sbjct: 4 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPN 63
Query: 1402 LVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEHGI 1459
LV V + +++ EYCD L E+ R G+ EH+++ + Q A+N H+H
Sbjct: 64 LVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNC 123
Query: 1460 VHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE-VNSTLGTAAYMAPEVITRAK 1518
+HRD+K NI +T +IKL DFG + L T P + + T Y +PE++
Sbjct: 124 IHRDVKPENILITKHSVIKLCDFGFARLL-----TGPSDYYTDYVATRWYRSPELL--VG 176
Query: 1519 GEGHGRAADIWSLGCVVIEMVTGKRPW---HEYEHNFQIMYKVG---------------- 1559
+G D+W++GCV E+++G W + + + I +G
Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236
Query: 1560 MGHKPPIPERLSPEGKDF----------LSHCLESDPKMRWTASQLLDHSF 1600
G K P PE + P F L CL DP R T QLL H +
Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPY 287
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 137 bits (345), Expect = 8e-32
Identities = 88/272 (32%), Positives = 131/272 (48%), Gaps = 11/272 (4%)
Query: 1334 VGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKI 1393
V L+ +++ ++G G YG VY T EL A+K ++ P D I E+ I
Sbjct: 7 VSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD--ISSLQQEITI 64
Query: 1394 FEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQITIAI 1451
+HPN+V Y G L + ++I ME+C G+L+E+ L+E I ++ +
Sbjct: 65 LRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGL 124
Query: 1452 NVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAP 1511
+ LH G +HRDIKGAN+ LT G +KL DFG S +L + + S +GT +MAP
Sbjct: 125 HHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASV----AKRRSFIGTPYWMAP 180
Query: 1512 EVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPP---IPE 1568
EV + G+ D+W+LG IE+ + P +M +PP
Sbjct: 181 EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT 240
Query: 1569 RLSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1600
R + FL L +PK R TA +LL H F
Sbjct: 241 RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,713,456
Number of Sequences: 37866
Number of extensions: 3502432
Number of successful extensions: 57844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1106
Number of HSP's successfully gapped in prelim test: 539
Number of HSP's that attempted gapping in prelim test: 34062
Number of HSP's gapped (non-prelim): 13797
length of query: 1608
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1492
effective length of database: 13,855,062
effective search space: 20671752504
effective search space used: 20671752504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.