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Search of human proteins with 55770840
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55770840 chloride channel 3 isoform e [Homo sapiens]
(866 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 1766 0.0
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 1627 0.0
gi|153252026 chloride channel 4 [Homo sapiens] 1238 0.0
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 1226 0.0
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 1226 0.0
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 1187 0.0
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 248 1e-65
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 248 1e-65
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 228 2e-59
gi|156104869 chloride channel 2 [Homo sapiens] 216 7e-56
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 195 2e-49
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 176 1e-43
gi|155969705 chloride channel Kb [Homo sapiens] 174 2e-43
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 174 2e-43
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 114 3e-25
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 69 1e-11
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 69 1e-11
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 32 2.5
gi|226437579 NAC alpha domain containing [Homo sapiens] 31 5.7
gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens] 31 5.7
gi|239749105 PREDICTED: NAC alpha domain containing [Homo sapiens] 31 5.7
gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens] 31 5.7
gi|239508792 PREDICTED: NAC alpha domain containing [Homo sapiens] 31 5.7
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 1766 bits (4574), Expect = 0.0
Identities = 866/866 (100%), Positives = 866/866 (100%)
Query: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60
MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT
Sbjct: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60
Query: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120
NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK
Sbjct: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120
Query: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180
SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT
Sbjct: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180
Query: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240
FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG
Sbjct: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240
Query: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300
IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF
Sbjct: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300
Query: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360
PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360
Query: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420
FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS
Sbjct: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420
Query: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480
TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA
Sbjct: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480
Query: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540
SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI
Sbjct: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540
Query: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600
VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
Sbjct: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600
Query: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660
TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP
Sbjct: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660
Query: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR
Sbjct: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
Query: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780
KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL
Sbjct: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780
Query: 781 RQCLVTHNGIVLGIITKKNILEHLEQLKQHVEPLAPPWHYNKKRYPPAYGPDGKPRPRFN 840
RQCLVTHNGIVLGIITKKNILEHLEQLKQHVEPLAPPWHYNKKRYPPAYGPDGKPRPRFN
Sbjct: 781 RQCLVTHNGIVLGIITKKNILEHLEQLKQHVEPLAPPWHYNKKRYPPAYGPDGKPRPRFN 840
Query: 841 NVQLNLTDEEREETEEEVYLLNSTTL 866
NVQLNLTDEEREETEEEVYLLNSTTL
Sbjct: 841 NVQLNLTDEEREETEEEVYLLNSTTL 866
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 1627 bits (4213), Expect = 0.0
Identities = 800/806 (99%), Positives = 803/806 (99%)
Query: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60
MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT
Sbjct: 1 MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT 60
Query: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120
NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK
Sbjct: 61 NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK 120
Query: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180
SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT
Sbjct: 121 SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT 180
Query: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240
FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG
Sbjct: 181 FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG 240
Query: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300
IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF
Sbjct: 241 IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF 300
Query: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360
PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 301 PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 360
Query: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420
FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS
Sbjct: 361 FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS 420
Query: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480
TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA
Sbjct: 421 TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA 480
Query: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540
SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI
Sbjct: 481 SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI 540
Query: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600
VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
Sbjct: 541 VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL 600
Query: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660
TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP
Sbjct: 601 TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP 660
Query: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR
Sbjct: 661 RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
Query: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780
KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL
Sbjct: 721 KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL 780
Query: 781 RQCLVTHNGIVLGIITKKNILEHLEQ 806
RQCLVTHNG +LGIITKK+IL H+ Q
Sbjct: 781 RQCLVTHNGRLLGIITKKDILRHMAQ 806
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 1238 bits (3203), Expect = 0.0
Identities = 578/749 (77%), Positives = 665/749 (88%)
Query: 59 MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEM 118
M N G+++ S +L+D LDEP P VGTY+DFHTIDW+REK +D +RHR+I SK KES WE
Sbjct: 1 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60
Query: 119 TKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNE 178
KSL DAWSGW+V+ L GL +G LAG+ID+A DWMTDLKEG+CLSA WY+HEQCCW SNE
Sbjct: 61 IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120
Query: 179 TTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACG 238
TTFE+RDKCP W+ W+EL++ Q+EG +YI+NY+MYI WAL FAFLAVSLV+VFAPYACG
Sbjct: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180
Query: 239 SGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSY 298
SGIPEIKTILSGFIIRGYLGKWTL+IKT+TLVL V+SGLSLGKEGPLVHVACCCGN FS
Sbjct: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240
Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
LF KYS NE K+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
Sbjct: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
Query: 359 AAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRR 418
AAF LRSINPFGNSRLVLFYVEYHTPWY+ ELFPFILLGVFGGLWG FIR NIAWCRRR
Sbjct: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360
Query: 419 KSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDM 478
K+T+ GKYPVLEVI+V AITA+IA+PNPYTR +TSELI ELF DCG LESS LCDY ND
Sbjct: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420
Query: 479 NASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAG 538
N ++ VDDIPDRPAG+GVY+A+WQL LALIFKI++T+FTFG+K+PSGLFIPSMA+GAIAG
Sbjct: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480
Query: 539 RIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVF 598
R+VGI VEQLAY+HHDW IF+ WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVI+F
Sbjct: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540
Query: 599 ELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVM 658
ELTGGLEYIVPLMAA +TSKWV DAFG+EGIYEAHI LNGYPFLD K+EFTH TLA DVM
Sbjct: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600
Query: 659 RPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIES 718
RPRR +PPL+VLTQD+MTV+D+E +I ET YNGFPV++S++S+RL+GFA RR+L +AI++
Sbjct: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660
Query: 719 ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKL 778
AR++QEGIV +S + F + P LPA SP PLKLR IL++SPFTVTDHTPME VVDIFRKL
Sbjct: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720
Query: 779 GLRQCLVTHNGIVLGIITKKNILEHLEQL 807
GLRQCLVT +G +LGIITKK++L H+ Q+
Sbjct: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQM 749
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 1226 bits (3172), Expect = 0.0
Identities = 583/800 (72%), Positives = 682/800 (85%), Gaps = 4/800 (0%)
Query: 8 HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67
+RG+ + S++S ++SSDE+L+D MDF +D LD + Y NGG I S
Sbjct: 10 NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66
Query: 68 STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127
S ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+S
Sbjct: 67 SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126
Query: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187
GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKC
Sbjct: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186
Query: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247
P+W +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246
Query: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307
LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NE
Sbjct: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306
Query: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367
AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366
Query: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427
PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426
Query: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++
Sbjct: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485
Query: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547
PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545
Query: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607
LAYYH +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605
Query: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667
VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665
Query: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727
VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725
Query: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787
+S + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785
Query: 788 NGIVLGIITKKNILEHLEQL 807
NG +LGIITKK++L+H+ Q+
Sbjct: 786 NGRLLGIITKKDVLKHIAQM 805
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 1226 bits (3172), Expect = 0.0
Identities = 583/800 (72%), Positives = 682/800 (85%), Gaps = 4/800 (0%)
Query: 8 HRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINS 67
+RG+ + S++S ++SSDE+L+D MDF +D LD + Y NGG I S
Sbjct: 10 NRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSY---NGGGIGS 66
Query: 68 STHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWS 127
S ++D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+S
Sbjct: 67 SNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFS 126
Query: 128 GWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKC 187
GWL++ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKC
Sbjct: 127 GWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKC 186
Query: 188 PQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTI 247
P+W +W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTI
Sbjct: 187 PEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTI 246
Query: 248 LSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNE 307
LSGFIIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NE
Sbjct: 247 LSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNE 306
Query: 308 AKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367
AK+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSIN
Sbjct: 307 AKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 366
Query: 368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYP 427
PFGNSRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYP
Sbjct: 367 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYP 426
Query: 428 VLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
V+EV++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++
Sbjct: 427 VIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGEL 485
Query: 488 PDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQ 547
PDRPAG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQ
Sbjct: 486 PDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQ 545
Query: 548 LAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYI 607
LAYYH +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYI
Sbjct: 546 LAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYI 605
Query: 608 VPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPL 667
VPLMAA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L
Sbjct: 606 VPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLL 665
Query: 668 AVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIV 727
VLTQD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V
Sbjct: 666 TVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVV 725
Query: 728 GSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTH 787
+S + F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTH
Sbjct: 726 STSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTH 785
Query: 788 NGIVLGIITKKNILEHLEQL 807
NG +LGIITKK++L+H+ Q+
Sbjct: 786 NGRLLGIITKKDVLKHIAQM 805
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 1187 bits (3072), Expect = 0.0
Identities = 560/736 (76%), Positives = 647/736 (87%), Gaps = 1/736 (0%)
Query: 72 LDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLV 131
+D L+EPIPGVGTYDDF+TIDWVREK +DR+RHR I +K KES W + S+ DA+SGWL+
Sbjct: 1 MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 60
Query: 132 VTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWK 191
+ L GL SG+LAGLIDI+A WMTDLKEGIC W+NHE CCW S TFEERDKCP+W
Sbjct: 61 MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 120
Query: 192 TWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 251
+W++LII EG +YI+NY MY+ WAL FAFLAVSLVKVFAPYACGSGIPEIKTILSGF
Sbjct: 121 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 180
Query: 252 IIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKR 311
IIRGYLGKWTL+IKTITLVLAV+SGLSLGKEGPLVHVACCCGNI + F KY NEAK+R
Sbjct: 181 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 240
Query: 312 EVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGN 371
EVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAF LRSINPFGN
Sbjct: 241 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 300
Query: 372 SRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEV 431
SRLVLFYVE+HTPW+LFEL PFILLG+FGGLWGA FIR NIAWCR+RK+T+ GKYPV+EV
Sbjct: 301 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 360
Query: 432 IIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRP 491
++V AITA++AFPN YTR++TSELI ELF DCG L+SS LCDY N N SK ++PDRP
Sbjct: 361 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSK-GGELPDRP 419
Query: 492 AGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYY 551
AG+GVYSA+WQL L LI KI++T+FTFG+K+PSGLFIPSMA+GAIAGR++G+ +EQLAYY
Sbjct: 420 AGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYY 479
Query: 552 HHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLM 611
H +W +F WC GADCITPGLYAMVGAAACLGGVTRMTVSLVVI+FELTGGLEYIVPLM
Sbjct: 480 HQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLM 539
Query: 612 AAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLT 671
AA MTSKWV DA GREGIY+AHIRLNGYPFL+AKEEF H TLA DVM+PRRNDP L VLT
Sbjct: 540 AAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLT 599
Query: 672 QDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSR 731
QD+MTV+D+E +I+ET+Y+GFPV++S+ESQRLVGF LRRDL I+IE+ARKKQ+G+V +S
Sbjct: 600 QDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSI 659
Query: 732 VCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIV 791
+ F +H+P LP +P LKLR+ILD+SPFTVTD TPMEIVVDIFRKLGLRQCLVTHNG +
Sbjct: 660 IYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRL 719
Query: 792 LGIITKKNILEHLEQL 807
LGIITKK++L+H+ Q+
Sbjct: 720 LGIITKKDVLKHIAQM 735
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 248 bits (634), Expect = 1e-65
Identities = 210/723 (29%), Positives = 338/723 (46%), Gaps = 107/723 (14%)
Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
W++ L G+ +G +A IDI + + LK + N F E+
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 145
Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
G + +++ +F + +V P A GSGIP+IK L
Sbjct: 146 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 189
Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298
+G I + TL+IK ++L+V GL++GKEGP++H S +
Sbjct: 190 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 249
Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
+Y + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++ WR FFA+++
Sbjct: 250 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 309
Query: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408
+ F L ++ + L+ F + + + E+ FI +GV GG+ GA F
Sbjct: 310 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 369
Query: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461
N W + + V+E ++VAA+TA +AF Y+ L + L
Sbjct: 370 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 428
Query: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521
C E +S+ + +V D P G Y+ + L++ + +T+G+
Sbjct: 429 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 484
Query: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581
V +G+FIPS+ IGA GR+ GI++ L + AD PG YA++GAAA
Sbjct: 485 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 530
Query: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641
LGG+ RMT+SL VI+ E T + Y P+M +MT+K VGD F EG+Y+ HI+L PF
Sbjct: 531 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 589
Query: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696
L + T H+ A +VM + P + ++ + V I +++++T ++NGFPV+
Sbjct: 590 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 643
Query: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743
+ RL G LR L + ++ + G+V F P P
Sbjct: 644 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 703
Query: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GIVLGIITKKNI 800
E + L ++ SP+TV + V +FR LGLR +V N V+G++T+K++
Sbjct: 704 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 763
Query: 801 LEH 803
+
Sbjct: 764 ARY 766
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 248 bits (634), Expect = 1e-65
Identities = 210/723 (29%), Positives = 338/723 (46%), Gaps = 107/723 (14%)
Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
W++ L G+ +G +A IDI + + LK + N F E+
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169
Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
G + +++ +F + +V P A GSGIP+IK L
Sbjct: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298
+G I + TL+IK ++L+V GL++GKEGP++H S +
Sbjct: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
Query: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
+Y + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++ WR FFA+++
Sbjct: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
Query: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408
+ F L ++ + L+ F + + + E+ FI +GV GG+ GA F
Sbjct: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393
Query: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461
N W + + V+E ++VAA+TA +AF Y+ L + L
Sbjct: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452
Query: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521
C E +S+ + +V D P G Y+ + L++ + +T+G+
Sbjct: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508
Query: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581
V +G+FIPS+ IGA GR+ GI++ L + AD PG YA++GAAA
Sbjct: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554
Query: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641
LGG+ RMT+SL VI+ E T + Y P+M +MT+K VGD F EG+Y+ HI+L PF
Sbjct: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613
Query: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696
L + T H+ A +VM + P + ++ + V I +++++T ++NGFPV+
Sbjct: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667
Query: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743
+ RL G LR L + ++ + G+V F P P
Sbjct: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727
Query: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GIVLGIITKKNI 800
E + L ++ SP+TV + V +FR LGLR +V N V+G++T+K++
Sbjct: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
Query: 801 LEH 803
+
Sbjct: 788 ARY 790
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 228 bits (580), Expect = 2e-59
Identities = 182/627 (29%), Positives = 286/627 (45%), Gaps = 131/627 (20%)
Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
W+VV G+ +G + +D T LK G+ +T+ EE C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121
Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297
+G + G + TL+ K + ++ +VA GL +GKEGP++H G
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357
+ FP Y ++ KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285
Query: 358 VAAFVLR------SINPFGNSRL--VLFYVEYHTP--------WYLFELFPFILLGVFGG 401
A F L +G+ +L +L + E+ W +L F+++GV GG
Sbjct: 286 SATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGG 345
Query: 402 LWGAFFIRANIAWCRRRKSTKFGK---YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKE 458
L GA F N + R K VLE ++V+ +T V+ F +
Sbjct: 346 LLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVF-----------VASM 394
Query: 459 LFTDCGPLESSSLCDYRNDMNASKIVDDI-----------------------PDRPAGI- 494
+ +C + SSS ND ++ +D+ P A +
Sbjct: 395 VLGECRQMSSSS--QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQ 452
Query: 495 -----GVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLA 549
G +S + L L + ++ +T+GI VPSGLF+PS+ GA GR+V ++
Sbjct: 453 LFHQDGTFSPV-TLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSY- 510
Query: 550 YYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP 609
+G I G +A++GAAA LGGV RMT+SL VI+ E T + Y +P
Sbjct: 511 --------------IGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLP 556
Query: 610 LMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-AADVMRPRRNDPPLA 668
+M +M +KW GD F + GIY+ H+ L G P L+ + E L A+D+M P
Sbjct: 557 IMVTLMVAKWTGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPN------L 609
Query: 669 VLTQDNMTVDDIENMINETSYNGFPVI 695
+ + + +++ T ++ FPV+
Sbjct: 610 TYVYPHTRIQSLVSILRTTVHHAFPVV 636
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/82 (34%), Positives = 49/82 (59%), Gaps = 4/82 (4%)
Query: 737 HTPSLPAESPRPL-KLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQC-LVTHNGIVLGI 794
H L +PR + + ++ SPFTV+ +T + V ++FR +GLR +V G ++GI
Sbjct: 788 HDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGI 847
Query: 795 ITKKNI-LEHLE-QLKQHVEPL 814
IT+ N+ E L+ +L+QH + +
Sbjct: 848 ITRHNLTYEFLQARLRQHYQTI 869
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 216 bits (550), Expect = 7e-56
Identities = 172/539 (31%), Positives = 259/539 (48%), Gaps = 52/539 (9%)
Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
S ++ Y+ ++ + + + ++ AP A GSGIPE+KTIL G +++ YL T + K
Sbjct: 129 SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAK 188
Query: 266 TITLVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGV 322
I L A+ SG+ LGKEGP VH+A C + F LF NE++ E+L+AA A GV
Sbjct: 189 VIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGV 248
Query: 323 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---NPFGNSRLVLFYV 379
F APIGGVLFS+E S +F ++ WR FFAA +AF+ R + N + LF
Sbjct: 249 GCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKT 308
Query: 380 EYHT--PWYLFELFPFILLGVFGGLWGAFFIRAN--IAWCRRRKST-------KFGKYPV 428
+ P+ L EL F ++G+ G GA F+ N I R++ T K +P
Sbjct: 309 RFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368
Query: 429 LEVIIVAAITAVIAFPNPYTRLNTSELI-KELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
L ++++ +T FP + + +L KE +L D R + + +
Sbjct: 369 LVTLLISTLT----FPPGFGQFMAGQLSQKETLV--------TLFDNRTWVRQGLVEELE 416
Query: 488 PD------RPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIV 541
P P V+ L + ++ K M+ I VP G F+P IGA GR+V
Sbjct: 417 PPSTSQAWNPPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 473
Query: 542 GIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601
G E +A WF + I PG YA+VGAAA G VT TVS VIVFELT
Sbjct: 474 G---ESMA----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELT 525
Query: 602 GGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPR 661
G + +I+P+M AV+ + V + + +Y++ IR+ P+L H V
Sbjct: 526 GQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIM 584
Query: 662 RNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
D P L + T D+ ++ T ++ S ES L+G ++ R +A+ A+
Sbjct: 585 VRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLG-SIERSQVVALLGAQ 639
Score = 33.1 bits (74), Expect = 1.1
Identities = 16/51 (31%), Positives = 28/51 (54%)
Query: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLE 805
+D +PF + + T + IF LG+ VT G ++GI+T K + + +E
Sbjct: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 840
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 195 bits (495), Expect = 2e-49
Identities = 155/534 (29%), Positives = 250/534 (46%), Gaps = 55/534 (10%)
Query: 209 MNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 268
+ +++++ + L + + +P A GSGIPE+KTIL G +++ YL + K +
Sbjct: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
Query: 269 LVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGVSVA 325
L + SG+ +GKEGP VH+A C + F +F ++L+ A GV
Sbjct: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
Query: 326 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRL---VLFYVEYH 382
FG P+GGVLFS+E S YF ++ WR FFAA +AFV R + + + LF +
Sbjct: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
Query: 383 T--PWYLFELFPFILLGVFGGLWGAFFI---RANIAWCRRRK--STKFGKYPVLEVIIVA 435
P+ L EL F +G+ GL GA F+ R + R+ K S K+ +L IV
Sbjct: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
Query: 436 AITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIG 495
+ A FP + EL+ P E+ S + N+ D P +G
Sbjct: 399 FVIASFTFPPGMGQFMAGELM--------PREAISTL-FDNNTWVKHAGD-----PESLG 444
Query: 496 VYSAIW---------QLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVE 546
SA+W + L + K M++ + +P G F+P +GA GR+VG E
Sbjct: 445 -QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---E 500
Query: 547 QLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEY 606
+A D +F + I PG YA++GAAA G V+ TVS VI FELTG + +
Sbjct: 501 IMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAH 555
Query: 607 IVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA---KEEFTHTTLAADVMRPRRN 663
I+P+M AV+ + V + + +Y++ I++ P+L + +T D+M
Sbjct: 556 ILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRD-- 612
Query: 664 DPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIE 717
+ T ++ ++ T+ P++ SK+S L+G R +L ++
Sbjct: 613 ----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQ 662
Score = 32.0 bits (71), Expect = 2.5
Identities = 17/63 (26%), Positives = 30/63 (47%)
Query: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLEQLKQHVEPL 814
+D SPF + + T + +F LGL VT G + G++ + + + +E + L
Sbjct: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQL 880
Query: 815 APP 817
PP
Sbjct: 881 RPP 883
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 176 bits (445), Expect = 1e-43
Identities = 166/635 (26%), Positives = 276/635 (43%), Gaps = 98/635 (15%)
Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
S+++ Y+ + + ++ + + P + GSGIPE+KT+L+G I+ YL K
Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317
+ L LA S L LGK GP VH++ I +YL +T N++K+ E+L AA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204
Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373
+A GV+ F AP GVLFS+E +S +F ++ WR FFAA AF+ R + F + +
Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264
Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425
L P+ L E+F F+ LG G+ ++ + K+ ++
Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324
Query: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483
Y L +++A+IT +P S L + D SL D N A
Sbjct: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371
Query: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532
+ P P + W+ L L+ K M + I +P+G F+P
Sbjct: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431
Query: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590
+GA GR++G A+ F E G + I PG YA+ GAAA G VT T
Sbjct: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481
Query: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647
+S ++ FELTG + + +P++ AV+ + + + + Y+ I + P+L +
Sbjct: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540
Query: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707
+H M + + L +D ++++ ++ T +P++ S ESQ LVG
Sbjct: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594
Query: 708 LRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSIL----DMSPFTVT 763
R L A+++ P+ +P L+ IL P T+T
Sbjct: 595 QRAQLVQALQA---------------------EPPSRAPGHQCLQDILARGCPTEPVTLT 633
Query: 764 --DHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIIT 796
T + ++F+ L L+ VT G +G ++
Sbjct: 634 LFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVS 668
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 174 bits (442), Expect = 2e-43
Identities = 166/630 (26%), Positives = 273/630 (43%), Gaps = 87/630 (13%)
Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
S+++ Y+ + + ++ + + P + GSGIPE+KT+L+G ++ YL K
Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAK 147
Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317
+ L LA S L LGK GP VH++ +YL +T N++K+ E+L AA
Sbjct: 148 VVGLSCTLACGSTLFLGKVGPFVHLSVMMA---AYLGRVRTTTIGEPENKSKQNEMLVAA 204
Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373
+A GV+ F AP GVLFS+E +S +F + WR FFAA AF+ R + F + +
Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETIT 264
Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAF----------FIRANIAWCRRRKSTK 422
L P+ L E+F F+ LG G+ G+ FIR N + + +T
Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNN-RFSSKLLATS 323
Query: 423 FGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASK 482
Y L +++A+IT +P R S L + D SL D N A
Sbjct: 324 KPVYSALATLVLASIT----YPPSAGRFLASRLSMKQHLD-------SLFD--NHSWALM 370
Query: 483 IVDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSM 531
+ P P + W+ L L+ K M + I +P+G F+P
Sbjct: 371 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF 430
Query: 532 AIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRM 589
GA GR+ G + FIF E G + I PG YA+ GAAA G VT
Sbjct: 431 VYGAAIGRLFGETLS---------FIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTH- 480
Query: 590 TVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKE 646
T+S ++ FE+TG + + +P++ AV+ + + + + Y+ + + P+L +
Sbjct: 481 TISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTVIVKKLPYLPRILGRN 539
Query: 647 EFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGF 706
+H M + + L +D M ++++ ++ T +P++ S ESQ LVG
Sbjct: 540 IGSHRVRVEHFM-----NHSITTLAKD-MPLEEVVKVVTSTDVAKYPLVESTESQILVGI 593
Query: 707 ALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHT 766
R L +++ + + + C + P LKL + T
Sbjct: 594 VRRAQL---VQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKL-----------SPET 639
Query: 767 PMEIVVDIFRKLGLRQCLVTHNGIVLGIIT 796
+ ++F L L VT G +G ++
Sbjct: 640 SLHEAHNLFELLNLHSLFVTSRGRAVGCVS 669
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 174 bits (442), Expect = 2e-43
Identities = 163/630 (25%), Positives = 274/630 (43%), Gaps = 87/630 (13%)
Query: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
S+++ Y+ + + ++ + + P + GSGIPE+KT+L+G I+ YL K
Sbjct: 88 SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
Query: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317
+ L LA S L LGK GP VH++ I +YL +T N++K+ E+L AA
Sbjct: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204
Query: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373
+A GV+ F AP GVLFS+E +S +F ++ WR FFAA AF+ R + F + +
Sbjct: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264
Query: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425
L P+ L E+F F+ LG G+ ++ + K+ ++
Sbjct: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324
Query: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483
Y L +++A+IT +P S L + D SL D N A
Sbjct: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371
Query: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532
+ P P + W+ L L+ K M + I +P+G F+P
Sbjct: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431
Query: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590
+GA GR++G A+ F E G + I PG YA+ GAAA G VT T
Sbjct: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481
Query: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647
+S ++ FELTG + + +P++ AV+ + + + + Y+ I + P+L +
Sbjct: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540
Query: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707
+H M + + L +D ++++ ++ T +P++ S ESQ LVG
Sbjct: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594
Query: 708 LRRDLTIAIES-ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHT 766
R L A+++ + G + A+ P+ P T+ T
Sbjct: 595 QRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPV---------------TLTLFSET 639
Query: 767 PMEIVVDIFRKLGLRQCLVTHNGIVLGIIT 796
+ ++F+ L L+ VT G +G ++
Sbjct: 640 TLHQAQNLFKLLNLQSLFVTSRGRAVGCVS 669
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 114 bits (286), Expect = 3e-25
Identities = 80/246 (32%), Positives = 120/246 (48%), Gaps = 46/246 (18%)
Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
W+VV G+ +G + +D T LK G+ +T+ EE C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121
Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCG-----------NIFS 297
+G + G + TL+ K + ++ +VA GL +GKEGP++H G
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 298 YLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAAL 357
+ FP Y ++ KR+ +SA +AAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 227 FNFP-YFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSM 285
Query: 358 VAAFVL 363
A F L
Sbjct: 286 SATFTL 291
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 38/182 (20%)
Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
W+VV G+ +G + +D T LK G+ +T+ EE C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121
Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEA 308
+G + G + TL+ K + ++ +VA GL +GKEGP++H G++ P++ +
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIH----SGSVVGAGLPQFQSISL 222
Query: 309 KK 310
+K
Sbjct: 223 RK 224
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 38/182 (20%)
Query: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
W+VV G+ +G + +D T LK G+ +T+ EE C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVV----------------QTSVEE---CS 121
Query: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Q G ++ + + + L+F FLA SL+ + P A GSGIPE+K L
Sbjct: 122 Q--------------KGCLALSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEA 308
+G + G + TL+ K + ++ +VA GL +GKEGP++H G++ P++ +
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIH----SGSVVGAGLPQFQSISL 222
Query: 309 KK 310
+K
Sbjct: 223 RK 224
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 32.0 bits (71), Expect = 2.5
Identities = 27/119 (22%), Positives = 49/119 (41%), Gaps = 22/119 (18%)
Query: 511 IIMTVFTF-GIKVPSGLFIPSMAIGAIAGRIV----GIAVEQLAYYHHDWFIFKEWCEVG 565
+I+ VFT +K P LF+ S+A I + +A E + Y W+ K WCE+
Sbjct: 69 VIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY----WYFGKAWCEI- 123
Query: 566 ADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVP----LMAAVMTSKWV 620
Y + C + + + + +T +EY + + A++ + WV
Sbjct: 124 --------YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWV 174
>gi|226437579 NAC alpha domain containing [Homo sapiens]
Length = 1562
Score = 30.8 bits (68), Expect = 5.7
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 23/99 (23%)
Query: 777 KLGLRQC------LVTHNGIVLGIITKKNILEH-------------LEQLKQHVEPLAPP 817
KLGLRQ + + +L +I K ++ + +E L Q V A
Sbjct: 1423 KLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAE 1482
Query: 818 WHYNKKRYPPAYGPDGKPRPRFNNVQLNLTDEEREETEE 856
+ P A P+ PRPR V+L +EE EE EE
Sbjct: 1483 -KFKVPSEPSALVPESAPRPR---VRLECKEEEEEEEEE 1517
>gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens]
Length = 1522
Score = 30.8 bits (68), Expect = 5.7
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 23/99 (23%)
Query: 777 KLGLRQC------LVTHNGIVLGIITKKNILEH-------------LEQLKQHVEPLAPP 817
KLGLRQ + + +L +I K ++ + +E L Q V A
Sbjct: 1383 KLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAE 1442
Query: 818 WHYNKKRYPPAYGPDGKPRPRFNNVQLNLTDEEREETEE 856
+ P A P+ PRPR V+L +EE EE EE
Sbjct: 1443 -KFKVPSEPSALVPESAPRPR---VRLECKEEEEEEEEE 1477
>gi|239749105 PREDICTED: NAC alpha domain containing [Homo sapiens]
Length = 1522
Score = 30.8 bits (68), Expect = 5.7
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 23/99 (23%)
Query: 777 KLGLRQC------LVTHNGIVLGIITKKNILEH-------------LEQLKQHVEPLAPP 817
KLGLRQ + + +L +I K ++ + +E L Q V A
Sbjct: 1383 KLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAE 1442
Query: 818 WHYNKKRYPPAYGPDGKPRPRFNNVQLNLTDEEREETEE 856
+ P A P+ PRPR V+L +EE EE EE
Sbjct: 1443 -KFKVPSEPSALVPESAPRPR---VRLECKEEEEEEEEE 1477
>gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens]
Length = 1562
Score = 30.8 bits (68), Expect = 5.7
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 23/99 (23%)
Query: 777 KLGLRQC------LVTHNGIVLGIITKKNILEH-------------LEQLKQHVEPLAPP 817
KLGLRQ + + +L +I K ++ + +E L Q V A
Sbjct: 1423 KLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAE 1482
Query: 818 WHYNKKRYPPAYGPDGKPRPRFNNVQLNLTDEEREETEE 856
+ P A P+ PRPR V+L +EE EE EE
Sbjct: 1483 -KFKVPSEPSALVPESAPRPR---VRLECKEEEEEEEEE 1517
>gi|239508792 PREDICTED: NAC alpha domain containing [Homo sapiens]
Length = 1522
Score = 30.8 bits (68), Expect = 5.7
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 23/99 (23%)
Query: 777 KLGLRQC------LVTHNGIVLGIITKKNILEH-------------LEQLKQHVEPLAPP 817
KLGLRQ + + +L +I K ++ + +E L Q V A
Sbjct: 1383 KLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAE 1442
Query: 818 WHYNKKRYPPAYGPDGKPRPRFNNVQLNLTDEEREETEE 856
+ P A P+ PRPR V+L +EE EE EE
Sbjct: 1443 -KFKVPSEPSALVPESAPRPR---VRLECKEEEEEEEEE 1477
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,975,341
Number of Sequences: 37866
Number of extensions: 1465135
Number of successful extensions: 3630
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3555
Number of HSP's gapped (non-prelim): 31
length of query: 866
length of database: 18,247,518
effective HSP length: 111
effective length of query: 755
effective length of database: 14,044,392
effective search space: 10603515960
effective search space used: 10603515960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.