BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|55743071 ATPase, Cu++ transporting, beta polypeptide isoform a [Homo sapiens] (1465 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|55743071 ATPase, Cu++ transporting, beta polypeptide isoform ... 2862 0.0 gi|115529486 ATPase, Cu++ transporting, alpha polypeptide [Homo ... 1539 0.0 gi|55743073 ATPase, Cu++ transporting, beta polypeptide isoform ... 1360 0.0 gi|48762691 calcium-transporting ATPase 2C1 isoform 1b [Homo sap... 93 2e-18 gi|48762689 calcium-transporting ATPase 2C1 isoform 1d [Homo sap... 93 2e-18 gi|48762687 calcium-transporting ATPase 2C1 isoform 1c [Homo sap... 93 2e-18 gi|48762685 calcium-transporting ATPase 2C1 isoform 1a [Homo sap... 93 2e-18 gi|28373103 ATPase, Ca++ transporting, ubiquitous isoform a [Hom... 87 2e-16 gi|28373115 ATPase, Ca++ transporting, ubiquitous isoform c [Hom... 87 2e-16 gi|28373113 ATPase, Ca++ transporting, ubiquitous isoform f [Hom... 87 2e-16 gi|28373111 ATPase, Ca++ transporting, ubiquitous isoform c [Hom... 87 2e-16 gi|28373109 ATPase, Ca++ transporting, ubiquitous isoform b [Hom... 87 2e-16 gi|28373107 ATPase, Ca++ transporting, ubiquitous isoform d [Hom... 87 2e-16 gi|28373105 ATPase, Ca++ transporting, ubiquitous isoform e [Hom... 87 2e-16 gi|4502285 ATPase, Ca++ transporting, slow twitch 2 isoform 2 [H... 85 4e-16 gi|24638454 ATPase, Ca++ transporting, slow twitch 2 isoform 1 [... 85 4e-16 gi|209413709 ATPase, Ca++ transporting, slow twitch 2 isoform 3 ... 85 4e-16 gi|10835220 ATPase, Ca++ transporting, fast twitch 1 isoform b [... 85 4e-16 gi|27886529 ATPase, Ca++ transporting, fast twitch 1 isoform a [... 85 4e-16 gi|118498343 ATPase, Ca++ transporting, type 2C, member 2 [Homo ... 84 1e-15 gi|83700225 hydrogen/potassium-exchanging ATPase 12A [Homo sapiens] 80 1e-14 gi|48255947 plasma membrane calcium ATPase 1 isoform 1a [Homo sa... 78 5e-14 gi|48255945 plasma membrane calcium ATPase 1 isoform 1b [Homo sa... 78 5e-14 gi|213972621 ATPase type 13A2 isoform 3 [Homo sapiens] 78 7e-14 gi|153946397 Na+/K+ -ATPase alpha 4 subunit isoform 1 [Homo sapi... 77 9e-14 gi|51944966 hydrogen/potassium-exchanging ATPase 4A [Homo sapiens] 76 2e-13 gi|4502271 Na+/K+ -ATPase alpha 2 subunit proprotein [Homo sapiens] 76 3e-13 gi|22748667 Na+/K+ -ATPase alpha 3 subunit [Homo sapiens] 75 4e-13 gi|48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo sa... 75 5e-13 gi|48255957 plasma membrane calcium ATPase 4 isoform 4b [Homo sa... 75 5e-13 >gi|55743071 ATPase, Cu++ transporting, beta polypeptide isoform a [Homo sapiens] Length = 1465 Score = 2862 bits (7420), Expect = 0.0 Identities = 1465/1465 (100%), Positives = 1465/1465 (100%) Query: 1 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS 60 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS Sbjct: 1 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS 60 Query: 61 TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG 120 TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG Sbjct: 61 TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG 120 Query: 121 FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN 180 FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN Sbjct: 121 FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN 180 Query: 181 QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN 240 QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN Sbjct: 181 QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN 240 Query: 241 QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK 300 QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK Sbjct: 241 QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK 300 Query: 301 YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST 360 YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST Sbjct: 301 YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST 360 Query: 361 TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM 420 TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM Sbjct: 361 TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM 420 Query: 421 GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ 480 GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ Sbjct: 421 GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ 480 Query: 481 STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL 540 STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL Sbjct: 481 STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL 540 Query: 541 EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA 600 EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA Sbjct: 541 EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA 600 Query: 601 TSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVF 660 TSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVF Sbjct: 601 TSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVF 660 Query: 661 GIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYK 720 GIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYK Sbjct: 661 GIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYK 720 Query: 721 SLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWL 780 SLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWL Sbjct: 721 SLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWL 780 Query: 781 EHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFP 840 EHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFP Sbjct: 781 EHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFP 840 Query: 841 VDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIV 900 VDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIV Sbjct: 841 VDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIV 900 Query: 901 KLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH 960 KLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH Sbjct: 901 KLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH 960 Query: 961 ISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHK 1020 ISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHK Sbjct: 961 ISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHK 1020 Query: 1021 IKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK 1080 IKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK Sbjct: 1021 IKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK 1080 Query: 1081 EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAV 1140 EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAV Sbjct: 1081 EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAV 1140 Query: 1141 PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQ 1200 PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQ Sbjct: 1141 PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQ 1200 Query: 1201 EAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK 1260 EAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK Sbjct: 1201 EAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK 1260 Query: 1261 KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR 1320 KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR Sbjct: 1261 KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR 1320 Query: 1321 IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPD 1380 IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPD Sbjct: 1321 IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPD 1380 Query: 1381 LERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSR 1440 LERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSR Sbjct: 1381 LERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSR 1440 Query: 1441 HSAAADDDGDKWSLLLNGRDEEQYI 1465 HSAAADDDGDKWSLLLNGRDEEQYI Sbjct: 1441 HSAAADDDGDKWSLLLNGRDEEQYI 1465 >gi|115529486 ATPase, Cu++ transporting, alpha polypeptide [Homo sapiens] Length = 1500 Score = 1539 bits (3984), Expect = 0.0 Identities = 826/1461 (56%), Positives = 1045/1461 (71%), Gaps = 66/1461 (4%) Query: 38 AFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGS 97 A D++G++ + P + + + + I+ + KG+ +K+ ++ + Sbjct: 65 AIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRT 124 Query: 98 ATVKYVPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLP-AQEAVVKLRVEGMTCQS 156 V +PS+V Q+ + ++ + E K+ + S+ A E V+K++VEGMTC S Sbjct: 125 VAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHS 184 Query: 157 CVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAP 216 C S+IEGK+ KLQGV R+KVSL NQEA I YQP+LI E+++ + MGF A +K + Sbjct: 185 CTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKY 244 Query: 217 LSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIE 276 L LG ID+ERL++T P+ S+ + S + + T IDGMHCKSCV NIE Sbjct: 245 LKLGAIDVERLKNT----PVKSSEGSQQRSPSYTNDS----TATFIIDGMHCKSCVSNIE 296 Query: 277 ENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGT 336 + L V SI VSLEN++A VKY+ S +P +L++AIEA+ PG ++VS+ E + Sbjct: 297 STLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSN 356 Query: 337 DHRSSSSHSPGSPPRNQV-QGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLA 395 S SS S P N V Q T+I I GMTC SCV SIEG+IS+ GV+ I VSLA Sbjct: 357 ---SPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLA 413 Query: 396 EGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTS 455 TV Y+P + SPE LR AIEDMGF+A++ S + PL P+S Sbjct: 414 NSNGTVEYDPLLTSPETLRGAIEDMGFDATL---SDTNEPL-----------VVIAQPSS 459 Query: 456 VQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAG 515 + T + K + KC++Q+ GMTCASCV+NIERNL++E G Sbjct: 460 EMPLLTSTNEFYTKGMTPVQDKEEGKNSS----KCYIQVTGMTCASCVANIERNLRREEG 515 Query: 516 VLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTC 575 + S+LVALMAGKAE++Y+P VIQP IA+FI++LGF A V+E+ DG +EL + GMTC Sbjct: 516 IYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTC 575 Query: 576 ASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRN 635 ASCVH IES LT+ GI Y SVALAT+KA +K+DPEIIGPRDII IE +GF ASL +++ Sbjct: 576 ASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKD 635 Query: 636 PNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNE-----------------P 678 +A HLDHK EI+QW++SFL SL F IPVM LMIYM++ + Sbjct: 636 RSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINL 695 Query: 679 HQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATS 738 H SM L+ I+PGLS++NL+ F+LC VQ GGWYFY+QAYK+L+H++ANMDVLIVLAT+ Sbjct: 696 HSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATT 755 Query: 739 IAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSL 798 IA+ YSL+IL+VA+ E+A+ +P+TFFDTPPMLFVFIALGRWLEH+AK KTSEALAKL+SL Sbjct: 756 IAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISL 815 Query: 799 QATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLIT 858 QATEAT+VTL DN+++ EEQV +ELVQRGDI+KVVPGGKFPVDG+V+EG++M DESLIT Sbjct: 816 QATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLIT 875 Query: 859 GEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLAD 918 GEAMPV KKPGSTVIAGSIN +GS+LI ATHVG DTTL+QIVKLVEEAQ SKAPIQQ AD Sbjct: 876 GEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFAD 935 Query: 919 RFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITV 978 + SGYFVPFI+ +S TL+VWIVIGF++F +V+ YFP N+ IS+TE IIRFAFQ SITV Sbjct: 936 KLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITV 995 Query: 979 LCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPR 1038 LCIACPCSLGLATPTAVMVGTGV AQNGILIKGG+PLEMAHK+K V+FDKTGTITHG P Sbjct: 996 LCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPV 1055 Query: 1039 VMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVP 1098 V +V +L + + K+LA+VGTAE++SEHPLG A+TKYCK+EL TETLG C DFQ VP Sbjct: 1056 VNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVP 1115 Query: 1099 GCGIGCKVSNVEGILAHSERPLS-----------APASHLNEAGSLPAEKDAV------P 1141 GCGI CKV+N+EG+L + + AS+ + S DA Sbjct: 1116 GCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNA 1175 Query: 1142 QTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQE 1201 Q + VLIGNREW+ RNGL I++DV+D MT+HE KG+TA+LVA+D LCG+IAIAD VK E Sbjct: 1176 QQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPE 1235 Query: 1202 AALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKK 1261 A LA+H L+SMG++VVL+TGDN KTAR+IA+QVGI KVFAEVLPSHKVAKV++LQ +GK+ Sbjct: 1236 AELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKR 1295 Query: 1262 VAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRI 1321 VAMVGDG+NDSPALA A++G+AIGTGTDVAIEAADVVLIRNDLLDVVASI LS+ TV+RI Sbjct: 1296 VAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRETVKRI 1355 Query: 1322 RINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDL 1381 RIN V ALIYNLVGIPIAAGVFMPIG+VLQPWMGSAAMAASSVSVVLSSL LK Y+KP Sbjct: 1356 RINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTY 1415 Query: 1382 ERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRH 1441 E YE A + + S++SVH+G+DD R+SP+ D++ S+ S++SL SDK S + Sbjct: 1416 ESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLN 1475 Query: 1442 SAAADDDGDKWSLLLNGRDEE 1462 S + DK SLL+ E+ Sbjct: 1476 SVVTSEP-DKHSLLVGDFRED 1495 Score = 228 bits (582), Expect = 3e-59 Identities = 187/643 (29%), Positives = 281/643 (43%), Gaps = 121/643 (18%) Query: 51 LGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQ 110 + PS V + T+ + GMTC SCV +IE +I + G+ +KVSLE+ +AT+ Y P + + Sbjct: 1 MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPK 60 Query: 111 QVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQG 170 + I DMGF+A I LP + L V I+ + K +G Sbjct: 61 TLQEAIDDMGFDAVIHN-------PDPLPVLTDTLFLTVTASLTLPW-DHIQSTLLKTKG 112 Query: 171 VVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQST 230 V +K+ + +T P ++ IK V LSL +E+ Sbjct: 113 VTDIKIYPQKRTVAVTIIPSIVNANQ-------------IKELVPELSLDTGTLEKKSGA 159 Query: 231 NPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQV 290 ++ A + V L+++++GM C SC IE IG+L GVQ I+V Sbjct: 160 CEDHSMAQAGE---------------VVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKV 204 Query: 291 SLENKTAQVKYDPSCTSPVALQRAIEAL--------PPGNFKVSLPDGAEGSGTDHRSSS 342 SL+N+ A + Y P S +++ IEA+ P K+ D T +SS Sbjct: 205 SLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSE 264 Query: 343 SHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVL 402 GS R+ ST I GM C SCV +IE +S L+ V I VSL +A V Sbjct: 265 ----GSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVK 320 Query: 403 YNPSVISPEELRAAIEDMG---FEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEV 459 YN S ++PE LR AIE + + S+ SE V++T +P+S Sbjct: 321 YNASSVTPESLRKAIEAVSPGLYRVSITSE----------------VESTSNSPSS---- 360 Query: 460 APHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSV 519 ++P N L Q+ + I GMTC SCV +IE + K+ GV S+ Sbjct: 361 -SSLQKIPLNVVSQPLT-----------QETVINIDGMTCNSCVQSIEGVISKKPGVKSI 408 Query: 520 LVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVME---------------------- 557 V+L ++YDP + P + I+D+GF+A + + Sbjct: 409 RVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTN 468 Query: 558 -------------DYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKA 604 + + + +TGMTCASCV NIE L R GI VAL KA Sbjct: 469 EFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKA 528 Query: 605 LVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEI 647 V+++P +I P I + I E+GF A++ + NA D +E+ Sbjct: 529 EVRYNPAVIQPPMIAEFIRELGFGATVIE---NADEGDGVLEL 568 >gi|55743073 ATPase, Cu++ transporting, beta polypeptide isoform b [Homo sapiens] Length = 1258 Score = 1360 bits (3521), Expect = 0.0 Identities = 811/1360 (59%), Positives = 916/1360 (67%), Gaps = 190/1360 (13%) Query: 140 AQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRD 199 +Q A +R+ GMTCQSCV SIE ++ L+G++ +KVSL A + Y P ++ + + Sbjct: 55 SQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCH 114 Query: 200 HVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTL 259 + DMGFEA+I A ++ P R L + + Sbjct: 115 QIGDMGFEASIAEGKA-------------ASWPSRSLPAQE----------------AVV 145 Query: 260 QLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSP----------- 308 +LR++GM C+SCV +IE + +L GV ++VSL N+ A + Y P P Sbjct: 146 KLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMG 205 Query: 309 --VALQRAIEALPPGNFKVSLPDGAEG----SGTDHRSSSSHSPGSPPRNQVQGTCSTTL 362 A++ + L G + S + ++S + G QG+ TL Sbjct: 206 FEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGH------QGSHVVTL 259 Query: 363 -IAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMG 421 + I GM C SCV +IE I QL GVQ I VSL TA V Y+PS SP L+ AIE + Sbjct: 260 QLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEAL- 318 Query: 422 FEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQS 481 P GN S+ +G+ T + + H+ P P + S Sbjct: 319 -------------PPGNFKV--SLPDGAEGSGTDHRSSSSHSPGSP----PRNQVQGTCS 359 Query: 482 TRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLE 541 T +A I GMTCASCV +IE + + GV + V+L G A + Y+P VI P E Sbjct: 360 TTLIA-------IAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEE 412 Query: 542 IAQFIQDLGFEAAVMEDYAGSD--GNIELTITGMTCASCVHNIESKLTRTNGITYASV-- 597 + I+D+GFEA+V+ + ++ GN H+ + + +T T SV Sbjct: 413 LRAAIEDMGFEASVVSESCSTNPLGN--------------HSAGNSMVQTTDGTPTSVQE 458 Query: 598 -ALATSKALVKFDPEIIG--PRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWK-KS 653 A T + P+I+ P+ + + F ++IK S Sbjct: 459 VAPHTGRLPANHAPDILAKSPQSTRAVAPQKCF-----------------LQIKGMTCAS 501 Query: 654 FLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWY 713 + ++ + A ++ +L+ + D +I L I F+Q LG Sbjct: 502 CVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQ--------FIQDLG--- 550 Query: 714 FYVQAYKSLRHRSANMDVLIVLATSIAYVYSLV--------ILVVAVAEKAERSPVTFFD 765 F + N+++ I T + V+++ I +VA ++ V F Sbjct: 551 FEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDP 610 Query: 766 TPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELV 825 I R + + +SKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELV Sbjct: 611 E-------IIGPRDIIKIIESKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELV 663 Query: 826 QRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLI 885 QRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLI Sbjct: 664 QRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLI 723 Query: 886 KATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFI 945 KATHVGNDTTLAQIVKLVEEAQMSK Sbjct: 724 KATHVGNDTTLAQIVKLVEEAQMSK----------------------------------- 748 Query: 946 DFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN 1005 NPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN Sbjct: 749 ----------NPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN 798 Query: 1006 GILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEA 1065 GILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEA Sbjct: 799 GILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEA 858 Query: 1066 SSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPAS 1125 SSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPAS Sbjct: 859 SSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPAS 918 Query: 1126 HLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAID 1185 HLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAID Sbjct: 919 HLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAID 978 Query: 1186 GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLP 1245 GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLP Sbjct: 979 GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLP 1038 Query: 1246 SHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLL 1305 SHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLL Sbjct: 1039 SHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLL 1098 Query: 1306 DVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVS 1365 DVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVS Sbjct: 1099 DVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVS 1158 Query: 1366 VVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYV 1425 VVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYV Sbjct: 1159 VVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYV 1218 Query: 1426 SQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI 1465 SQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI Sbjct: 1219 SQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI 1258 Score = 1221 bits (3160), Expect = 0.0 Identities = 623/623 (100%), Positives = 623/623 (100%) Query: 1 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS 60 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS Sbjct: 1 MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS 60 Query: 61 TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG 120 TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG Sbjct: 61 TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG 120 Query: 121 FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN 180 FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN Sbjct: 121 FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN 180 Query: 181 QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN 240 QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN Sbjct: 181 QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN 240 Query: 241 QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK 300 QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK Sbjct: 241 QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK 300 Query: 301 YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST 360 YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST Sbjct: 301 YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST 360 Query: 361 TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM 420 TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM Sbjct: 361 TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM 420 Query: 421 GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ 480 GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ Sbjct: 421 GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ 480 Query: 481 STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL 540 STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL Sbjct: 481 STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL 540 Query: 541 EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA 600 EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA Sbjct: 541 EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA 600 Query: 601 TSKALVKFDPEIIGPRDIIKIIE 623 TSKALVKFDPEIIGPRDIIKIIE Sbjct: 601 TSKALVKFDPEIIGPRDIIKIIE 623 Score = 194 bits (494), Expect = 4e-49 Identities = 142/451 (31%), Positives = 214/451 (47%), Gaps = 78/451 (17%) Query: 232 PKRPLSSANQNFNNSETLGHQG--------SHVVTLQLRIDGMHCKSCVLNIEENIGQLL 283 P R A + + +G++G S V T +RI GM C+SCV +IE+ I L Sbjct: 25 PTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLK 84 Query: 284 GVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSS 343 G+ S++VSLE +A VKY PS V LQ+ + F+ S+ +G S Sbjct: 85 GIISMKVSLEQGSATVKYVPSV---VCLQQVCHQIGDMGFEASIAEGKAASW-------- 133 Query: 344 HSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLY 403 P + + + + GMTC SCV SIEG + +L+GV ++ VSL+ A + Y Sbjct: 134 ------PSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITY 187 Query: 404 NPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHT 463 P +I PE+LR + DMGFEA++ S+ + LG P ++ + Sbjct: 188 QPYLIQPEDLRDHVNDMGFEAAIKSKVAPLS-LG---------------PIDIERLQSTN 231 Query: 464 GRLPANHAPDILAKSP----QSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSV 519 + P + A S Q + V Q L+I GM C SCV NIE N+ + GV S+ Sbjct: 232 PKRPLSSANQNFNNSETLGHQGSHVVTLQ---LRIDGMHCKSCVLNIEENIGQLLGVQSI 288 Query: 520 LVALMAGKAEIKYDPEVIQPLEIAQFIQDL---GFEAAVMEDYAGS-------------- 562 V+L A++KYDP P+ + + I+ L F+ ++ + GS Sbjct: 289 QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGS 348 Query: 563 ------DGNIELT---ITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEII 613 G T I GMTCASCVH+IE +++ G+ SV+LA A V ++P +I Sbjct: 349 PPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVI 408 Query: 614 GPRDIIKIIEEIGFHASLAQR----NPNAHH 640 P ++ IE++GF AS+ NP +H Sbjct: 409 SPEELRAAIEDMGFEASVVSESCSTNPLGNH 439 Score = 185 bits (470), Expect = 2e-46 Identities = 137/436 (31%), Positives = 205/436 (47%), Gaps = 74/436 (16%) Query: 25 PTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLK 84 P R A + + +G++G S V T +RI GM C+SCV +IE+ I L Sbjct: 232 PKRPLSSANQNFNNSETLGHQG--------SHVVTLQLRIDGMHCKSCVLNIEENIGQLL 283 Query: 85 GIISMKVSLEQGSATVKYVPSV---VCLQQVCHQIGDMGFEASIAEGKAASW-------- 133 G+ S++VSLE +A VKY PS V LQ+ + F+ S+ +G S Sbjct: 284 GVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSS 343 Query: 134 ------PSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITY 187 P + + + + GMTC SCV SIEG + +L+GV ++ VSL+ A + Y Sbjct: 344 HSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLY 403 Query: 188 QPYLIQPEDLRDHVNDMGFEAAIKSKVAPLS-LG---------------PIDIERLQSTN 231 P +I PE+LR + DMGFEA++ S+ + LG P ++ + Sbjct: 404 NPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHT 463 Query: 232 PKRPLSSANQNFNNSETLGHQGSHVVTLQ---LRIDGMHCKSCVLNIEENIGQLLGVQSI 288 + P + A S Q + V Q L+I GM C SCV NIE N+ + GV S+ Sbjct: 464 GRLPANHAPDILAKSP----QSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSV 519 Query: 289 QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGS 348 V+L A++KYDP P+ + + I+ L F+ ++ + GS Sbjct: 520 LVALMAGKAEIKYDPEVIQPLEIAQFIQDL---GFEAAVMEDYAGS-------------- 562 Query: 349 PPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVI 408 G T I GMTCASCVH+IE +++ G+ SV+LA A V ++P +I Sbjct: 563 ------DGNIELT---ITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEII 613 Query: 409 SPEELRAAIEDMGFEA 424 P ++ IE EA Sbjct: 614 GPRDIIKIIESKTSEA 629 Score = 98.2 bits (243), Expect = 5e-20 Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 9/150 (6%) Query: 62 VRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGF 121 ++I GMTC SCV +IE + G++S+ V+L G A +KY P V+ ++ I D+GF Sbjct: 492 LQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGF 551 Query: 122 EASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQ 181 EA++ E A S + ++L + GMTC SCV +IE K+ + G+ V+L+ Sbjct: 552 EAAVMEDYAGS---------DGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATS 602 Query: 182 EAVITYQPYLIQPEDLRDHVNDMGFEAAIK 211 +A++ + P +I P D+ + EA K Sbjct: 603 KALVKFDPEIIGPRDIIKIIESKTSEALAK 632 >gi|48762691 calcium-transporting ATPase 2C1 isoform 1b [Homo sapiens] Length = 939 Score = 93.2 bits (230), Expect = 2e-18 Identities = 58/161 (36%), Positives = 86/161 (53%), Gaps = 28/161 (17%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINK----------- 1238 G++ I D + AV TL + GV + +ITGD+++TA AIA+++G+ Sbjct: 540 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEI 599 Query: 1239 ----------------VFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGV 1282 VF P HK+ ++ LQ G VAM GDGVND+ AL AD+GV Sbjct: 600 DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGV 659 Query: 1283 AIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIR 1322 A+G TGTDV EAAD++L+ +D ++++I K I+ Sbjct: 660 AMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 700 Score = 46.2 bits (108), Expect = 2e-04 Identities = 60/287 (20%), Positives = 111/287 (38%), Gaps = 47/287 (16%) Query: 764 FDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPME 823 FD + V I + + + + ++ ++L +L L E V G+ + + VP Sbjct: 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP-- 157 Query: 824 LVQRGDIVKVVPGGKFPVDGKVLEGNTMA-DESLITGEAMPVTK--KPGSTVIAGSINAH 880 GD V + G + P D ++ E ++ DES +TGE P +K P G + + Sbjct: 158 ----GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213 Query: 881 GSVLIKATHV------------GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGY--FVP 926 ++ T V G ++ ++ K+++ + K P+Q+ D F Sbjct: 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYS 273 Query: 927 FIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCS 986 F II + LV W++ K I + F S+++ A P Sbjct: 274 FGII-GIIMLVGWLL----------------GKDILEM-------FTISVSLAVAAIPEG 309 Query: 987 LGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 L + + +G + ++K +E + DKTGT+T Sbjct: 310 LPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356 >gi|48762689 calcium-transporting ATPase 2C1 isoform 1d [Homo sapiens] Length = 949 Score = 93.2 bits (230), Expect = 2e-18 Identities = 58/161 (36%), Positives = 86/161 (53%), Gaps = 28/161 (17%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINK----------- 1238 G++ I D + AV TL + GV + +ITGD+++TA AIA+++G+ Sbjct: 540 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEI 599 Query: 1239 ----------------VFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGV 1282 VF P HK+ ++ LQ G VAM GDGVND+ AL AD+GV Sbjct: 600 DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGV 659 Query: 1283 AIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIR 1322 A+G TGTDV EAAD++L+ +D ++++I K I+ Sbjct: 660 AMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 700 Score = 46.2 bits (108), Expect = 2e-04 Identities = 60/287 (20%), Positives = 111/287 (38%), Gaps = 47/287 (16%) Query: 764 FDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPME 823 FD + V I + + + + ++ ++L +L L E V G+ + + VP Sbjct: 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP-- 157 Query: 824 LVQRGDIVKVVPGGKFPVDGKVLEGNTMA-DESLITGEAMPVTK--KPGSTVIAGSINAH 880 GD V + G + P D ++ E ++ DES +TGE P +K P G + + Sbjct: 158 ----GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213 Query: 881 GSVLIKATHV------------GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGY--FVP 926 ++ T V G ++ ++ K+++ + K P+Q+ D F Sbjct: 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYS 273 Query: 927 FIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCS 986 F II + LV W++ K I + F S+++ A P Sbjct: 274 FGII-GIIMLVGWLL----------------GKDILEM-------FTISVSLAVAAIPEG 309 Query: 987 LGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 L + + +G + ++K +E + DKTGT+T Sbjct: 310 LPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356 >gi|48762687 calcium-transporting ATPase 2C1 isoform 1c [Homo sapiens] Length = 888 Score = 93.2 bits (230), Expect = 2e-18 Identities = 58/161 (36%), Positives = 86/161 (53%), Gaps = 28/161 (17%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINK----------- 1238 G++ I D + AV TL + GV + +ITGD+++TA AIA+++G+ Sbjct: 540 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEI 599 Query: 1239 ----------------VFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGV 1282 VF P HK+ ++ LQ G VAM GDGVND+ AL AD+GV Sbjct: 600 DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGV 659 Query: 1283 AIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIR 1322 A+G TGTDV EAAD++L+ +D ++++I K I+ Sbjct: 660 AMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 700 Score = 46.2 bits (108), Expect = 2e-04 Identities = 60/287 (20%), Positives = 111/287 (38%), Gaps = 47/287 (16%) Query: 764 FDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPME 823 FD + V I + + + + ++ ++L +L L E V G+ + + VP Sbjct: 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP-- 157 Query: 824 LVQRGDIVKVVPGGKFPVDGKVLEGNTMA-DESLITGEAMPVTK--KPGSTVIAGSINAH 880 GD V + G + P D ++ E ++ DES +TGE P +K P G + + Sbjct: 158 ----GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213 Query: 881 GSVLIKATHV------------GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGY--FVP 926 ++ T V G ++ ++ K+++ + K P+Q+ D F Sbjct: 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYS 273 Query: 927 FIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCS 986 F II + LV W++ K I + F S+++ A P Sbjct: 274 FGII-GIIMLVGWLL----------------GKDILEM-------FTISVSLAVAAIPEG 309 Query: 987 LGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 L + + +G + ++K +E + DKTGT+T Sbjct: 310 LPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356 >gi|48762685 calcium-transporting ATPase 2C1 isoform 1a [Homo sapiens] Length = 919 Score = 93.2 bits (230), Expect = 2e-18 Identities = 58/161 (36%), Positives = 86/161 (53%), Gaps = 28/161 (17%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINK----------- 1238 G++ I D + AV TL + GV + +ITGD+++TA AIA+++G+ Sbjct: 540 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEI 599 Query: 1239 ----------------VFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGV 1282 VF P HK+ ++ LQ G VAM GDGVND+ AL AD+GV Sbjct: 600 DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGV 659 Query: 1283 AIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIR 1322 A+G TGTDV EAAD++L+ +D ++++I K I+ Sbjct: 660 AMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 700 Score = 46.2 bits (108), Expect = 2e-04 Identities = 60/287 (20%), Positives = 111/287 (38%), Gaps = 47/287 (16%) Query: 764 FDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPME 823 FD + V I + + + + ++ ++L +L L E V G+ + + VP Sbjct: 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP-- 157 Query: 824 LVQRGDIVKVVPGGKFPVDGKVLEGNTMA-DESLITGEAMPVTK--KPGSTVIAGSINAH 880 GD V + G + P D ++ E ++ DES +TGE P +K P G + + Sbjct: 158 ----GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213 Query: 881 GSVLIKATHV------------GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGY--FVP 926 ++ T V G ++ ++ K+++ + K P+Q+ D F Sbjct: 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYS 273 Query: 927 FIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCS 986 F II + LV W++ K I + F S+++ A P Sbjct: 274 FGII-GIIMLVGWLL----------------GKDILEM-------FTISVSLAVAAIPEG 309 Query: 987 LGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 L + + +G + ++K +E + DKTGT+T Sbjct: 310 LPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356 >gi|28373103 ATPase, Ca++ transporting, ubiquitous isoform a [Homo sapiens] Length = 999 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|28373115 ATPase, Ca++ transporting, ubiquitous isoform c [Homo sapiens] Length = 1029 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|28373113 ATPase, Ca++ transporting, ubiquitous isoform f [Homo sapiens] Length = 998 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|28373111 ATPase, Ca++ transporting, ubiquitous isoform c [Homo sapiens] Length = 1029 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|28373109 ATPase, Ca++ transporting, ubiquitous isoform b [Homo sapiens] Length = 1043 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|28373107 ATPase, Ca++ transporting, ubiquitous isoform d [Homo sapiens] Length = 1044 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|28373105 ATPase, Ca++ transporting, ubiquitous isoform e [Homo sapiens] Length = 1052 Score = 86.7 bits (213), Expect = 2e-16 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 31/158 (19%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-------- 1236 D G + + D + E A + G+ VV+ITGDN+ TA AI ++GI Sbjct: 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVA 649 Query: 1237 -----------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 + FA V P+HK V+ LQ+ + AM GDGVND+P Sbjct: 650 GKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 AL +A++G+A+G+GT VA AA++VL ++ +VA++ Sbjct: 710 ALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAV 747 Score = 67.8 bits (164), Expect = 7e-11 Identities = 76/338 (22%), Positives = 141/338 (41%), Gaps = 51/338 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + +LV V+A E+ E + F + ++ + +A +G W E A+S Sbjct: 60 LLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAES----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKVL 846 A EA E +IR ++ ++ ++ GDIV+V G K P D +++ Sbjct: 115 --------AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLI 166 Query: 847 EGNTMA---DESLITGEAMPVTKKPGST-------------VIAGSINAHGSVLIKATHV 890 E + D+S++TGE++ VTK + + +G+ G + A Sbjct: 167 EIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G T L +I + + + P+Q+ D F I S + + VW++ IG Sbjct: 227 GLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAI---SVICVAVWVINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S + + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFADPAHGGSWLRGAVYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGD 1047 + +E + DKTGT+T V R+ ++ + Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE 371 >gi|4502285 ATPase, Ca++ transporting, slow twitch 2 isoform 2 [Homo sapiens] Length = 997 Score = 85.1 bits (209), Expect = 4e-16 Identities = 52/153 (33%), Positives = 82/153 (53%), Gaps = 31/153 (20%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI------------- 1236 G + + D + E A +V + G+ V++ITGDN+ TA AI ++GI Sbjct: 594 GCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFT 653 Query: 1237 ------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQA 1278 + FA V PSHK V+ LQ+ + AM GDGVND+PAL +A Sbjct: 654 GREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKA 713 Query: 1279 DMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 ++G+A+G+GT VA A+++VL ++ +VA++ Sbjct: 714 EIGIAMGSGTAVAKTASEMVLADDNFSTIVAAV 746 Score = 63.2 bits (152), Expect = 2e-09 Identities = 76/346 (21%), Positives = 145/346 (41%), Gaps = 55/346 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + + + V+A E+ E + F + +L + +A +G W E A++ Sbjct: 60 LLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAEN----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKV- 845 A EA E + R+++ ++ ++ GDIV++ G K P D ++ Sbjct: 115 --------AIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLT 166 Query: 846 -LEGNTM-ADESLITGEAMPVTKKPG-------------STVIAGSINAHGSVLIKATHV 890 ++ T+ D+S++TGE++ V K + + +G+ A G + Sbjct: 167 SIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G +T + +I + + + P+QQ D F ++S + + VWI+ IG Sbjct: 227 GVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSK---VISLICIAVWIINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S I + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFNDPVHGGSWIRGAIYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLL----GDVATL 1051 + +E + DKTGT+T V R+ +L GD +L Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSL 379 >gi|24638454 ATPase, Ca++ transporting, slow twitch 2 isoform 1 [Homo sapiens] Length = 1042 Score = 85.1 bits (209), Expect = 4e-16 Identities = 52/153 (33%), Positives = 82/153 (53%), Gaps = 31/153 (20%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI------------- 1236 G + + D + E A +V + G+ V++ITGDN+ TA AI ++GI Sbjct: 594 GCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFT 653 Query: 1237 ------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQA 1278 + FA V PSHK V+ LQ+ + AM GDGVND+PAL +A Sbjct: 654 GREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKA 713 Query: 1279 DMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 ++G+A+G+GT VA A+++VL ++ +VA++ Sbjct: 714 EIGIAMGSGTAVAKTASEMVLADDNFSTIVAAV 746 Score = 63.2 bits (152), Expect = 2e-09 Identities = 76/346 (21%), Positives = 145/346 (41%), Gaps = 55/346 (15%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + + + V+A E+ E + F + +L + +A +G W E A++ Sbjct: 60 LLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAEN----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQR-----GDIVKVVPGGKFPVDGKV- 845 A EA E + R+++ ++ ++ GDIV++ G K P D ++ Sbjct: 115 --------AIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLT 166 Query: 846 -LEGNTM-ADESLITGEAMPVTKKPG-------------STVIAGSINAHGSVLIKATHV 890 ++ T+ D+S++TGE++ V K + + +G+ A G + Sbjct: 167 SIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVAT 226 Query: 891 GNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGV 949 G +T + +I + + + P+QQ D F ++S + + VWI+ IG Sbjct: 227 GVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSK---VISLICIAVWIINIG------ 277 Query: 950 VQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILI 1009 +F +P S I + F+ ++ + A P L T + +GT A+ ++ Sbjct: 278 ---HFNDPVHGGSWIRGAIYY-FKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIV 333 Query: 1010 KGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLL----GDVATL 1051 + +E + DKTGT+T V R+ +L GD +L Sbjct: 334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSL 379 >gi|209413709 ATPase, Ca++ transporting, slow twitch 2 isoform 3 [Homo sapiens] Length = 1015 Score = 85.1 bits (209), Expect = 4e-16 Identities = 52/153 (33%), Positives = 82/153 (53%), Gaps = 31/153 (20%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI------------- 1236 G + + D + E A +V + G+ V++ITGDN+ TA AI ++GI Sbjct: 567 GCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFT 626 Query: 1237 ------------------NKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQA 1278 + FA V PSHK V+ LQ+ + AM GDGVND+PAL +A Sbjct: 627 GREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKA 686 Query: 1279 DMGVAIGTGTDVAIEAADVVLIRNDLLDVVASI 1311 ++G+A+G+GT VA A+++VL ++ +VA++ Sbjct: 687 EIGIAMGSGTAVAKTASEMVLADDNFSTIVAAV 719 Score = 50.1 bits (118), Expect = 2e-05 Identities = 68/325 (20%), Positives = 130/325 (40%), Gaps = 40/325 (12%) Query: 735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIA---LGRWLEHLAKSKTSEA 791 L I + + + V+A E+ E + F + +L + +A +G W E A++ Sbjct: 60 LLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAEN----- 114 Query: 792 LAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTM 851 A EA E + R+++ ++ ++ DIV PG + G+ + Sbjct: 115 --------AIEALKEYEPEMGKVYRQDRKSVQRIKAKDIV---PGDIVEIAGESVSVIKH 163 Query: 852 ADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKA 911 D + V + + + +G+ A G + G +T + +I + + + Sbjct: 164 TDP---VPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERT 220 Query: 912 PIQQLADRFSGYFVPFIIIMSTLTLVVWIV-IGFIDFGVVQRYFPNPNKHISQTEVIIRF 970 P+QQ D F ++S + + VWI+ IG +F +P S I + Sbjct: 221 PLQQKLDEFGEQLSK---VISLICIAVWIINIG---------HFNDPVHGGSWIRGAIYY 268 Query: 971 AFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTG 1030 F+ ++ + A P L T + +GT A+ +++ +E + DKTG Sbjct: 269 -FKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG 327 Query: 1031 TITHGVPRVMRVLLL----GDVATL 1051 T+T V R+ +L GD +L Sbjct: 328 TLTTNQMSVCRMFILDRVEGDTCSL 352 >gi|10835220 ATPase, Ca++ transporting, fast twitch 1 isoform b [Homo sapiens] Length = 994 Score = 85.1 bits (209), Expect = 4e-16 Identities = 57/195 (29%), Positives = 99/195 (50%), Gaps = 32/195 (16%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI---NK--- 1238 D G++ + D ++E ++ + G+ V++ITGDN+ TA AI ++GI N+ Sbjct: 590 DLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVA 649 Query: 1239 -------------------------VFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 FA V PSHK V+ LQ+ + AM GDGVND+P Sbjct: 650 DRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNL 1333 AL +A++G+A+G+GT VA A+++VL ++ +VA++ + ++ + LI + Sbjct: 710 ALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMK-QFIRYLISSN 768 Query: 1334 VGIPIAAGVFMPIGI 1348 VG + + +G+ Sbjct: 769 VGEVVCIFLTAALGL 783 Score = 63.9 bits (154), Expect = 1e-09 Identities = 80/364 (21%), Positives = 152/364 (41%), Gaps = 58/364 (15%) Query: 712 WYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLF 771 W ++ ++ L R +++LA I++V +A E+ E + F + +L Sbjct: 50 WELVIEQFEDLLVR------ILLLAACISFV-------LAWFEEGEETITAFVEPFVILL 96 Query: 772 VFIA---LGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRG 828 + IA +G W E A++ A+ L + V ++ +++ + G Sbjct: 97 ILIANAIVGVWQERNAEN----AIEALKEYEPEMGKVYRADRKSV----QRIKARDIVPG 148 Query: 829 DIVKVVPGGKFPVDGKVL--EGNTM-ADESLITGEAMPVTKKPG-------------STV 872 DIV+V G K P D ++L + T+ D+S++TGE++ V K + + Sbjct: 149 DIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNML 208 Query: 873 IAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMS 932 +G+ A G L G T + +I + + K P+QQ D F ++S Sbjct: 209 FSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSK---VIS 265 Query: 933 TLTLVVWIV-IGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLAT 991 + + VW++ IG +F +P S I + F+ ++ + A P L Sbjct: 266 LICVAVWLINIG---------HFNDPVHGGSWFRGAIYY-FKIAVALAVAAIPEGLPAVI 315 Query: 992 PTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLL----GD 1047 T + +GT A+ +++ +E + DKTGT+T V ++ ++ GD Sbjct: 316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGD 375 Query: 1048 VATL 1051 + L Sbjct: 376 ICLL 379 >gi|27886529 ATPase, Ca++ transporting, fast twitch 1 isoform a [Homo sapiens] Length = 1001 Score = 85.1 bits (209), Expect = 4e-16 Identities = 57/195 (29%), Positives = 99/195 (50%), Gaps = 32/195 (16%) Query: 1185 DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI---NK--- 1238 D G++ + D ++E ++ + G+ V++ITGDN+ TA AI ++GI N+ Sbjct: 590 DLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVA 649 Query: 1239 -------------------------VFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSP 1273 FA V PSHK V+ LQ+ + AM GDGVND+P Sbjct: 650 DRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAP 709 Query: 1274 ALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNL 1333 AL +A++G+A+G+GT VA A+++VL ++ +VA++ + ++ + LI + Sbjct: 710 ALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMK-QFIRYLISSN 768 Query: 1334 VGIPIAAGVFMPIGI 1348 VG + + +G+ Sbjct: 769 VGEVVCIFLTAALGL 783 Score = 63.9 bits (154), Expect = 1e-09 Identities = 80/364 (21%), Positives = 152/364 (41%), Gaps = 58/364 (15%) Query: 712 WYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLF 771 W ++ ++ L R +++LA I++V +A E+ E + F + +L Sbjct: 50 WELVIEQFEDLLVR------ILLLAACISFV-------LAWFEEGEETITAFVEPFVILL 96 Query: 772 VFIA---LGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRG 828 + IA +G W E A++ A+ L + V ++ +++ + G Sbjct: 97 ILIANAIVGVWQERNAEN----AIEALKEYEPEMGKVYRADRKSV----QRIKARDIVPG 148 Query: 829 DIVKVVPGGKFPVDGKVL--EGNTM-ADESLITGEAMPVTKKPG-------------STV 872 DIV+V G K P D ++L + T+ D+S++TGE++ V K + + Sbjct: 149 DIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNML 208 Query: 873 IAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMS 932 +G+ A G L G T + +I + + K P+QQ D F ++S Sbjct: 209 FSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSK---VIS 265 Query: 933 TLTLVVWIV-IGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLAT 991 + + VW++ IG +F +P S I + F+ ++ + A P L Sbjct: 266 LICVAVWLINIG---------HFNDPVHGGSWFRGAIYY-FKIAVALAVAAIPEGLPAVI 315 Query: 992 PTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLL----GD 1047 T + +GT A+ +++ +E + DKTGT+T V ++ ++ GD Sbjct: 316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGD 375 Query: 1048 VATL 1051 + L Sbjct: 376 ICLL 379 >gi|118498343 ATPase, Ca++ transporting, type 2C, member 2 [Homo sapiens] Length = 946 Score = 84.0 bits (206), Expect = 1e-15 Identities = 55/154 (35%), Positives = 78/154 (50%), Gaps = 28/154 (18%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAI------------------- 1230 G++ I D + AV L GV V +ITGD +TA AI Sbjct: 570 GLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEV 629 Query: 1231 --------ATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGV 1282 A +VG VF P HK+ ++ LQ G VAM GDGVND+ AL AD+G+ Sbjct: 630 DSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGI 689 Query: 1283 AIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSK 1315 A+G TGTDV+ EAA+++L+ +D ++ ++ K Sbjct: 690 AMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGK 723 Score = 55.1 bits (131), Expect = 5e-07 Identities = 53/261 (20%), Positives = 104/261 (39%), Gaps = 43/261 (16%) Query: 787 KTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVL 846 ++ ++L +L + E + G+ ++ E VP GD+V + G + P D ++ Sbjct: 154 RSEKSLEELTKMVPPECNCLREGKLQHLLARELVP------GDVVSLSIGDRIPADIRLT 207 Query: 847 E-GNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHV------------GND 893 E + + DES TGEA P +K G + +++ T V G Sbjct: 208 EVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGES 267 Query: 894 TTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFII-IMSTLTLVVWIVIGFIDFGVVQR 952 + ++ K+++ + K P+Q+ DR F I+ + L+ W Sbjct: 268 SQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGW------------- 314 Query: 953 YFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGG 1012 SQ + ++ F +++ A P L + +++G A+ +++K Sbjct: 315 ---------SQGKQLLSM-FTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKL 364 Query: 1013 KPLEMAHKIKTVMFDKTGTIT 1033 +E + DKTGT+T Sbjct: 365 PIVETLGCCSVLCSDKTGTLT 385 >gi|83700225 hydrogen/potassium-exchanging ATPase 12A [Homo sapiens] Length = 1039 Score = 80.1 bits (196), Expect = 1e-14 Identities = 70/243 (28%), Positives = 107/243 (44%), Gaps = 69/243 (28%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI------------- 1236 G++++ D + AV +S G+ V+++TGD+ TA+AIA VGI Sbjct: 602 GLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAH 661 Query: 1237 ---------NK-------------------------------VFAEVLPSHKVAKVQELQ 1256 NK VFA P K+ V+ Q Sbjct: 662 RLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQ 721 Query: 1257 NKGKKVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASI---- 1311 + VA+ GDGVNDSPAL +AD+G+A+G G+D A AAD+VL+ ++ +V + Sbjct: 722 RQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGR 781 Query: 1312 ----HLSKRTVRRIRIN---LVLALIYNLVGIPIAAG----VFMPIGIVLQPWMGSAAMA 1360 +L K + N L LIY +VG+P+ G +F+ +G + P + A Sbjct: 782 LIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEK 841 Query: 1361 ASS 1363 A S Sbjct: 842 AES 844 Score = 40.8 bits (94), Expect = 0.010 Identities = 54/236 (22%), Positives = 88/236 (37%), Gaps = 38/236 (16%) Query: 813 LIIREEQ---VPMELVQRGDIVKVVPGGKFPVDGKVLEG-NTMADESLITGEAMPVTKKP 868 L+IR+ + +P E + GDIV+V G + P D +VL D S +TGE+ P + Sbjct: 185 LVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSS 244 Query: 869 GST----------VIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLAD 918 T + G+V + G+ T + I L K PI + Sbjct: 245 EFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIE 304 Query: 919 RFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITV 978 F + + L ++ + + + +V+ F I V Sbjct: 305 HFVHIVAGVAVSIGILFFIIAVSLKY--------------------QVLDSIIFLIGIIV 344 Query: 979 LCIACPCSLGLATPTAVMVGTGV-AAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 + P L LAT T + T A+ L+K + +E + DKTGT+T Sbjct: 345 ANV--PEGL-LATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLT 397 >gi|48255947 plasma membrane calcium ATPase 1 isoform 1a [Homo sapiens] Length = 1176 Score = 78.2 bits (191), Expect = 5e-14 Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 44/200 (22%) Query: 1184 IDGVLC-GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGIN----- 1237 + G+ C ++ I D V+ E A+ Q G+ V ++TGDN TARAIAT+ GI Sbjct: 671 VTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGED 730 Query: 1238 --------------------------------KVFAEVLPSHKVAKVQEL-----QNKGK 1260 +V A P+ K V+ + ++ + Sbjct: 731 FLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQ 790 Query: 1261 KVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVR 1319 VA+ GDG ND PAL +AD+G A+G GTDVA EA+D++L ++ +V ++ + Sbjct: 791 VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD 850 Query: 1320 RIRINLVLALIYNLVGIPIA 1339 I L L N+V + +A Sbjct: 851 SISKFLQFQLTVNVVAVIVA 870 Score = 39.3 bits (90), Expect = 0.028 Identities = 28/85 (32%), Positives = 44/85 (51%), Gaps = 13/85 (15%) Query: 819 QVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTM-ADESLITGEAMPVTKK--------PG 869 Q+P+ + GDI +V G P DG +++GN + DES +TGE+ V K G Sbjct: 204 QIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSG 263 Query: 870 STVIAGSINAHGSVLIKATHVGNDT 894 + V+ GS G +++ A V + T Sbjct: 264 THVMEGS----GRMVVTAVGVNSQT 284 Score = 32.0 bits (71), Expect = 4.5 Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 1/105 (0%) Query: 929 IIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLG 988 ++MS +T+++ ++ ID VQ+ + ++F F +TVL +A P L Sbjct: 378 LLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKF-FIIGVTVLVVAVPEGLP 436 Query: 989 LATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 LA ++ ++ L++ E + DKTGT+T Sbjct: 437 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 481 >gi|48255945 plasma membrane calcium ATPase 1 isoform 1b [Homo sapiens] Length = 1220 Score = 78.2 bits (191), Expect = 5e-14 Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 44/200 (22%) Query: 1184 IDGVLC-GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGIN----- 1237 + G+ C ++ I D V+ E A+ Q G+ V ++TGDN TARAIAT+ GI Sbjct: 671 VTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGED 730 Query: 1238 --------------------------------KVFAEVLPSHKVAKVQEL-----QNKGK 1260 +V A P+ K V+ + ++ + Sbjct: 731 FLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQ 790 Query: 1261 KVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVR 1319 VA+ GDG ND PAL +AD+G A+G GTDVA EA+D++L ++ +V ++ + Sbjct: 791 VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD 850 Query: 1320 RIRINLVLALIYNLVGIPIA 1339 I L L N+V + +A Sbjct: 851 SISKFLQFQLTVNVVAVIVA 870 Score = 39.3 bits (90), Expect = 0.028 Identities = 28/85 (32%), Positives = 44/85 (51%), Gaps = 13/85 (15%) Query: 819 QVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTM-ADESLITGEAMPVTKK--------PG 869 Q+P+ + GDI +V G P DG +++GN + DES +TGE+ V K G Sbjct: 204 QIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSG 263 Query: 870 STVIAGSINAHGSVLIKATHVGNDT 894 + V+ GS G +++ A V + T Sbjct: 264 THVMEGS----GRMVVTAVGVNSQT 284 Score = 32.0 bits (71), Expect = 4.5 Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 1/105 (0%) Query: 929 IIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLG 988 ++MS +T+++ ++ ID VQ+ + ++F F +TVL +A P L Sbjct: 378 LLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKF-FIIGVTVLVVAVPEGLP 436 Query: 989 LATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 LA ++ ++ L++ E + DKTGT+T Sbjct: 437 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 481 >gi|213972621 ATPase type 13A2 isoform 3 [Homo sapiens] Length = 1158 Score = 77.8 bits (190), Expect = 7e-14 Identities = 130/634 (20%), Positives = 223/634 (35%), Gaps = 159/634 (25%) Query: 770 LFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGD 829 +F+ ++ L K S+ L ++ L GE+ + E VP GD Sbjct: 258 IFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVP------GD 311 Query: 830 IVKVVP--GGKFPVDGKVLEGNTMADESLITGEAMPVTKKP------------------- 868 + V+P GG P D ++ G M +ES +TGE++PV K Sbjct: 312 CL-VLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLF 370 Query: 869 -GSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPF 927 G+ ++ VL T G T +V + + PI +F + + F Sbjct: 371 CGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSI----LHPRPIN---FKFYKHSMKF 423 Query: 928 IIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSL 987 + +S L L+ G + F + E++IR ++ ++ + P +L Sbjct: 424 VAALSVLALL----------GTIYSIFILYRNRVPLNEIVIR-----ALDLVTVVVPPAL 468 Query: 988 GLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVL---- 1043 A + + GI + + K++ V FDKTGT+T VM V+ Sbjct: 469 PAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKG 528 Query: 1044 -----LLGDVATLPLRKVLAVVGTAEASS---EHPLGVAVTKYCKEELGTETLGYCTDFQ 1095 L+ + LP+ +L + T A S + P+G + + E+ G+ + + Sbjct: 529 QAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPM-----DLKMVESTGWVLEEE 583 Query: 1096 AVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEK------DAVPQTFSVLI- 1148 G +V LA PL P E +P + Q SV++ Sbjct: 584 PAADSAFGTQV------LAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVA 637 Query: 1149 ------------GNREWLRR--NGLTISSDVSDAMTDHEMKGQTAILVAI---------- 1184 G+ E + N T+ +D + + + G + +A Sbjct: 638 WPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLE 697 Query: 1185 ------------DGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIAT 1232 D L G++ + + +K + + L+ + V++TGDN +TA +A Sbjct: 698 AAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVAR 757 Query: 1233 QVGI------------------------------------------NKVFAEVLPSHKVA 1250 G+ VFA + P K Sbjct: 758 GCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKVLVQGTVFARMAPEQKTE 817 Query: 1251 KVQELQNKGKKVAMVGDGVNDSPALAQADMGVAI 1284 V ELQ V M GDG ND AL AD+G+++ Sbjct: 818 LVCELQKLQYCVGMCGDGANDCGALKAADVGISL 851 >gi|153946397 Na+/K+ -ATPase alpha 4 subunit isoform 1 [Homo sapiens] Length = 1029 Score = 77.4 bits (189), Expect = 9e-14 Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 59/219 (26%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIAT----------------- 1232 G+I++ D + AV +S G+ V+++TGD+ TA+AIA Sbjct: 593 GLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAA 652 Query: 1233 --QVGINKV----------------------------------FAEVLPSHKVAKVQELQ 1256 ++ I+KV FA P K+ V+ Q Sbjct: 653 RLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQ 712 Query: 1257 NKGKKVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSK 1315 G VA+ GDGVNDSPAL +AD+G+A+G +G+DV+ +AAD++L+ ++ +V + + Sbjct: 713 RLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGR 772 Query: 1316 RTVRRIRINLVLALIYNLVGIP-----IAAGVFMPIGIV 1349 ++ +++ L N+ I I G+ +P+G + Sbjct: 773 LIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTI 811 Score = 46.6 bits (109), Expect = 2e-04 Identities = 57/277 (20%), Positives = 109/277 (39%), Gaps = 41/277 (14%) Query: 769 MLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRG 828 +L V + + + ++K+S+ + ++ +A V+ GE + Q+ ++ V G Sbjct: 143 VLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGE------KMQINVQEVVLG 196 Query: 829 DIVKVVPGGKFPVDGKVLEGN-TMADESLITGEAMPVTKKPGST---------VIAGSIN 878 D+V++ G + P D +++ D S +TGE+ P ++ P T + S N Sbjct: 197 DLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTN 256 Query: 879 A-HGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLV 937 G+ G+ T + +I L + + PI + F + + Sbjct: 257 CVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFA 316 Query: 938 VWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMV 997 + +++G+ E II I ++ P L LAT T + Sbjct: 317 LSLLLGY-----------------GWLEAIIFL-----IGIIVANVPEGL-LATVTVCLT 353 Query: 998 GTGVA-AQNGILIKGGKPLEMAHKIKTVMFDKTGTIT 1033 T A+ L+K + +E T+ DKTGT+T Sbjct: 354 LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLT 390 >gi|51944966 hydrogen/potassium-exchanging ATPase 4A [Homo sapiens] Length = 1035 Score = 76.3 bits (186), Expect = 2e-13 Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 59/219 (26%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVG-------------- 1235 G++++ D + AV ++ G+ V+++TGD+ TA+AIA VG Sbjct: 598 GLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAA 657 Query: 1236 --------INK-------------------------------VFAEVLPSHKVAKVQELQ 1256 +N+ VFA P K+ V+ Q Sbjct: 658 RLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQ 717 Query: 1257 NKGKKVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSK 1315 G VA+ GDGVNDSPAL +AD+GVA+G G+D A AAD++L+ ++ +V + + Sbjct: 718 RLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGR 777 Query: 1316 RTVRRIRINLVLALIYNLVG-----IPIAAGVFMPIGIV 1349 ++ ++ L N+ I I V +P+G + Sbjct: 778 LIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCI 816 Score = 50.1 bits (118), Expect = 2e-05 Identities = 67/302 (22%), Positives = 116/302 (38%), Gaps = 44/302 (14%) Query: 747 ILVVAVAEKAERSPVTFFDTPPMLFVFIAL---GRWLEHLAKSKTSEALAKLMSLQATEA 803 I ++A A +A +T D + IA+ + + K++ +A +L +A Sbjct: 121 ICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA 180 Query: 804 TVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGN-TMADESLITGEAM 862 TV+ G D I +Q+ + GD+V++ G + P D ++L D S +TGE+ Sbjct: 181 TVIRDG-DKFQINADQLVV-----GDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESE 234 Query: 863 PVTKKPGST----------VIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAP 912 P T+ P T ++ G+V + G+ T + +I L + K P Sbjct: 235 PQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTP 294 Query: 913 IQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAF 972 I + F I+ +V + IG+ + F Sbjct: 295 IAIEIEHFVDIIAGLAILFGATFFIVAMCIGY--------------------TFLRAMVF 334 Query: 973 QTSITVLCIACPCSLGLATPTAVMVGTGV-AAQNGILIKGGKPLEMAHKIKTVMFDKTGT 1031 +I V + P L LAT T + T A ++K + +E + DKTGT Sbjct: 335 FMAIVVAYV--PEGL-LATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGT 391 Query: 1032 IT 1033 +T Sbjct: 392 LT 393 >gi|4502271 Na+/K+ -ATPase alpha 2 subunit proprotein [Homo sapiens] Length = 1020 Score = 75.9 bits (185), Expect = 3e-13 Identities = 58/219 (26%), Positives = 102/219 (46%), Gaps = 59/219 (26%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI------------- 1236 G++++ D + AV +S G+ V+++TGD+ TA+AIA VGI Sbjct: 584 GLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAA 643 Query: 1237 ----------------------------NKVFAEVLPSH------------KVAKVQELQ 1256 ++ E+L +H K+ V+ Q Sbjct: 644 RLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQ 703 Query: 1257 NKGKKVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSK 1315 +G VA+ GDGVNDSPAL +AD+G+A+G +G+DV+ +AAD++L+ ++ +V + + Sbjct: 704 RQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGR 763 Query: 1316 RTVRRIRINLVLALIYNLVGIP-----IAAGVFMPIGIV 1349 ++ ++ L N+ I I A + +P+G V Sbjct: 764 LIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTV 802 Score = 52.0 bits (123), Expect = 4e-06 Identities = 60/261 (22%), Positives = 105/261 (40%), Gaps = 41/261 (15%) Query: 785 KSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGK 844 ++K+S+ + ++ +A V+ GE I EE V GD+V+V G + P D + Sbjct: 149 EAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVV------GDLVEVKGGDRVPADLR 202 Query: 845 VLEGN-TMADESLITGEAMPVTKKPGST---------VIAGSINA-HGSVLIKATHVGND 893 ++ + D S +TGE+ P T+ P T + S N G+ G+ Sbjct: 203 IISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDR 262 Query: 894 TTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRY 953 T + +I L ++ + PI + F + + V+ +++G+ Sbjct: 263 TVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGY--------- 313 Query: 954 FPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVA-AQNGILIKGG 1012 S E +I I ++ P L LAT T + T A+ L+K Sbjct: 314 --------SWLEAVIFL-----IGIIVANVPEGL-LATVTVCLTLTAKRMARKNCLVKNL 359 Query: 1013 KPLEMAHKIKTVMFDKTGTIT 1033 + +E T+ DKTGT+T Sbjct: 360 EAVETLGSTSTICSDKTGTLT 380 >gi|22748667 Na+/K+ -ATPase alpha 3 subunit [Homo sapiens] Length = 1013 Score = 75.5 bits (184), Expect = 4e-13 Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 59/219 (26%) Query: 1190 GMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI------------- 1236 G++++ D + AV +S G+ V+++TGD+ TA+AIA VGI Sbjct: 577 GLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAA 636 Query: 1237 ----------------------------NKVFAEVLPSH------------KVAKVQELQ 1256 ++ E+L +H K+ V+ Q Sbjct: 637 RLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQ 696 Query: 1257 NKGKKVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSK 1315 +G VA+ GDGVNDSPAL +AD+GVA+G G+DV+ +AAD++L+ ++ +V + + Sbjct: 697 RQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGR 756 Query: 1316 RTVRRIRINLVLALIYNLVGIP-----IAAGVFMPIGIV 1349 ++ ++ L N+ I I A + +P+G + Sbjct: 757 LIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTI 795 Score = 52.4 bits (124), Expect = 3e-06 Identities = 58/261 (22%), Positives = 106/261 (40%), Gaps = 41/261 (15%) Query: 785 KSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGK 844 ++K+S+ + ++ +A V+ GE + QV E V GD+V++ G + P D + Sbjct: 141 EAKSSKIMESFKNMVPQQALVIREGE------KMQVNAEEVVVGDLVEIKGGDRVPADLR 194 Query: 845 VLEGN-TMADESLITGEAMPVTKKPGST---------VIAGSINA-HGSVLIKATHVGND 893 ++ + D S +TGE+ P T+ P T + S N G+ G+ Sbjct: 195 IISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDR 254 Query: 894 TTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRY 953 T + +I L ++ K PI + F + + ++ +++G+ Sbjct: 255 TVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGY--------- 305 Query: 954 FPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVA-AQNGILIKGG 1012 + E +I I ++ P L LAT T + T A+ L+K Sbjct: 306 --------TWLEAVIFL-----IGIIVANVPEGL-LATVTVCLTLTAKRMARKNCLVKNL 351 Query: 1013 KPLEMAHKIKTVMFDKTGTIT 1033 + +E T+ DKTGT+T Sbjct: 352 EAVETLGSTSTICSDKTGTLT 372 >gi|48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo sapiens] Length = 1170 Score = 75.1 bits (183), Expect = 5e-13 Identities = 57/192 (29%), Positives = 87/192 (45%), Gaps = 43/192 (22%) Query: 1191 MIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-----------NKV 1239 ++ I D V+ E A+ + G+ V ++TGDN TARAIAT+ GI K Sbjct: 667 VVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKE 726 Query: 1240 FAEVLPSHKVAKVQELQNK-------------------------------GKKVAMVGDG 1268 F ++ + K QE +K + VA+ GDG Sbjct: 727 FNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDG 786 Query: 1269 VNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVL 1327 ND PAL +AD+G A+G GTDVA EA+D++L ++ +V ++ + I L Sbjct: 787 TNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 846 Query: 1328 ALIYNLVGIPIA 1339 L N+V + +A Sbjct: 847 QLTVNVVAVIVA 858 Score = 46.2 bits (108), Expect = 2e-04 Identities = 63/286 (22%), Positives = 107/286 (37%), Gaps = 59/286 (20%) Query: 819 QVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMA-DESLITGEAMPVTKK--------PG 869 Q+P+ + GDI +V G P DG +++GN + DES +TGE+ V K G Sbjct: 200 QLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSG 259 Query: 870 STVIAGS---------INAHGSVLIKATHVGNDT-------------------------- 894 + V+ GS +N+ +++ V D Sbjct: 260 THVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGV 319 Query: 895 --------------TLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWI 940 + K V+ + K+ +Q R + ++MS LT+ + I Sbjct: 320 ALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILI 379 Query: 941 VIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTG 1000 + ID V+ R P + ++F F ITVL +A P L LA ++ Sbjct: 380 LYFVIDNFVINRRPWLPECTPIYIQYFVKF-FIIGITVLVVAVPEGLPLAVTISLAYSVK 438 Query: 1001 VAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLG 1046 ++ L++ E + DKTGT+T V++ + G Sbjct: 439 KMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGG 484 >gi|48255957 plasma membrane calcium ATPase 4 isoform 4b [Homo sapiens] Length = 1205 Score = 75.1 bits (183), Expect = 5e-13 Identities = 57/192 (29%), Positives = 87/192 (45%), Gaps = 43/192 (22%) Query: 1191 MIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI-----------NKV 1239 ++ I D V+ E A+ + G+ V ++TGDN TARAIAT+ GI K Sbjct: 667 VVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKE 726 Query: 1240 FAEVLPSHKVAKVQELQNK-------------------------------GKKVAMVGDG 1268 F ++ + K QE +K + VA+ GDG Sbjct: 727 FNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDG 786 Query: 1269 VNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVL 1327 ND PAL +AD+G A+G GTDVA EA+D++L ++ +V ++ + I L Sbjct: 787 TNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 846 Query: 1328 ALIYNLVGIPIA 1339 L N+V + +A Sbjct: 847 QLTVNVVAVIVA 858 Score = 46.2 bits (108), Expect = 2e-04 Identities = 63/286 (22%), Positives = 107/286 (37%), Gaps = 59/286 (20%) Query: 819 QVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMA-DESLITGEAMPVTKK--------PG 869 Q+P+ + GDI +V G P DG +++GN + DES +TGE+ V K G Sbjct: 200 QLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSG 259 Query: 870 STVIAGS---------INAHGSVLIKATHVGNDT-------------------------- 894 + V+ GS +N+ +++ V D Sbjct: 260 THVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGV 319 Query: 895 --------------TLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWI 940 + K V+ + K+ +Q R + ++MS LT+ + I Sbjct: 320 ALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILI 379 Query: 941 VIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTG 1000 + ID V+ R P + ++F F ITVL +A P L LA ++ Sbjct: 380 LYFVIDNFVINRRPWLPECTPIYIQYFVKF-FIIGITVLVVAVPEGLPLAVTISLAYSVK 438 Query: 1001 VAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLG 1046 ++ L++ E + DKTGT+T V++ + G Sbjct: 439 KMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGG 484 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.132 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 51,613,374 Number of Sequences: 37866 Number of extensions: 2210133 Number of successful extensions: 6407 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 46 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 6052 Number of HSP's gapped (non-prelim): 211 length of query: 1465 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1350 effective length of database: 13,892,928 effective search space: 18755452800 effective search space used: 18755452800 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.