Search of human proteins with 54607089

Search of human proteins with 54607089

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
         (748 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]         1531   0.0  
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]          1526   0.0  
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     800   0.0  
gi|41406086 semaphorin 3D [Homo sapiens]                              679   0.0  
gi|188497703 semaphorin 3F [Homo sapiens]                             672   0.0  
gi|6912650 semaphorin 3E [Homo sapiens]                               662   0.0  
gi|9910362 semaphorin sem2 [Homo sapiens]                             659   0.0  
gi|5454048 semaphorin 3C [Homo sapiens]                               634   0.0  
gi|157388902 semaphorin 4C [Homo sapiens]                             344   2e-94
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   343   3e-94
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   321   2e-87
gi|28872814 semaphorin 4G [Homo sapiens]                              319   7e-87
gi|39777610 semaphorin 4B precursor [Homo sapiens]                    314   2e-85
gi|39777608 semaphorin 4B precursor [Homo sapiens]                    314   2e-85
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   303   5e-82
gi|21361914 semaphorin B [Homo sapiens]                               297   3e-80
gi|19923279 semaphorin W [Homo sapiens]                               293   4e-79
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          285   1e-76
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          285   1e-76
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          283   3e-76
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          283   4e-76
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          280   3e-75
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                    272   7e-73
gi|16306552 semaphorin Y [Homo sapiens]                               271   2e-72
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    261   1e-69
gi|147904700 semaphorin 5A [Homo sapiens]                             248   1e-65
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          240   4e-63
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]     220   3e-57
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]       218   2e-56
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]                   203   4e-52

>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score = 1531 bits (3963), Expect = 0.0
 Identities = 748/748 (100%), Positives = 748/748 (100%)

Query: 1   MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV 60
           MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV
Sbjct: 1   MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV 60

Query: 61  DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL 120
           DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL
Sbjct: 61  DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL 120

Query: 121 HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL 180
           HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL
Sbjct: 121 HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL 180

Query: 181 VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD 240
           VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD
Sbjct: 181 VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD 240

Query: 241 KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG 300
           KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG
Sbjct: 241 KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG 300

Query: 301 DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP 360
           DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP
Sbjct: 301 DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP 360

Query: 361 MHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLF 420
           MHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLF
Sbjct: 361 MHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLF 420

Query: 421 LQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHV 480
           LQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHV
Sbjct: 421 LQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHV 480

Query: 481 FEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVAC 540
           FEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVAC
Sbjct: 481 FEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVAC 540

Query: 541 TRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQARV 600
           TRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQARV
Sbjct: 541 TRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQARV 600

Query: 601 EWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLH 660
           EWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLH
Sbjct: 601 EWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLH 660

Query: 661 VLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLPL 720
           VLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLPL
Sbjct: 661 VLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLPL 720

Query: 721 ESRRKGRNRRTHAPEPRAERGPRSATHW 748
           ESRRKGRNRRTHAPEPRAERGPRSATHW
Sbjct: 721 ESRRKGRNRRTHAPEPRAERGPRSATHW 748


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score = 1526 bits (3951), Expect = 0.0
 Identities = 748/749 (99%), Positives = 748/749 (99%), Gaps = 1/749 (0%)

Query: 1   MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV 60
           MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV
Sbjct: 1   MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV 60

Query: 61  DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL 120
           DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL
Sbjct: 61  DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL 120

Query: 121 HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL 180
           HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL
Sbjct: 121 HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL 180

Query: 181 VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD 240
           VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD
Sbjct: 181 VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD 240

Query: 241 KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG 300
           KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG
Sbjct: 241 KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG 300

Query: 301 DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSS-IFQGSAVCVYSMNDVRRAFLGPFAHKEG 359
           DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSS IFQGSAVCVYSMNDVRRAFLGPFAHKEG
Sbjct: 301 DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEG 360

Query: 360 PMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419
           PMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL
Sbjct: 361 PMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 420

Query: 420 FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH 479
           FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH
Sbjct: 421 FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH 480

Query: 480 VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA 539
           VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA
Sbjct: 481 VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA 540

Query: 540 CTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQAR 599
           CTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQAR
Sbjct: 541 CTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQAR 600

Query: 600 VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL 659
           VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL
Sbjct: 601 VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL 660

Query: 660 HVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLP 719
           HVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLP
Sbjct: 661 HVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLP 720

Query: 720 LESRRKGRNRRTHAPEPRAERGPRSATHW 748
           LESRRKGRNRRTHAPEPRAERGPRSATHW
Sbjct: 721 LESRRKGRNRRTHAPEPRAERGPRSATHW 749


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  800 bits (2066), Expect = 0.0
 Identities = 401/769 (52%), Positives = 528/769 (68%), Gaps = 43/769 (5%)

Query: 13  LALLWAVGLGSAAP------SPPRLRLSFQELQAWHGLQTFS-LERTCCYQALLVDEERG 65
           + L W V L + A       + PRL+LS++E+   + + TF+ L  +  Y   L+DEER 
Sbjct: 8   VCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERS 67

Query: 66  RLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNR 125
           RL+VGA++H+ S +L NI K  +K+ WP     R+EC WAGKDI  EC NF+K+L AYN+
Sbjct: 68  RLYVGAKDHIFSFDLVNI-KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQ 126

Query: 126 THLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
           THL ACGTGAFHP C ++E+GH  E+ + +L+    E+G+GKSPYDP+   AS+L+  EL
Sbjct: 127 THLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGEL 186

Query: 186 YSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFF 245
           YSG AAD MGRDF IFR+LG    +RTE HDSRWLN+PKF+    I ES+NP+DDK+YFF
Sbjct: 187 YSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFF 246

Query: 246 FRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHF 304
           FRE A++   + G+ + +R+GQIC+ND GG RSLVNKWTTFLKARL+CSVPG  G DTHF
Sbjct: 247 FRENAIDGEHS-GKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHF 305

Query: 305 DQLQDVFLLSSRDHRTPLLYAVFSTSS-IFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQ 363
           D+LQDVFL++ +D + P++Y VF+TSS IF+GSAVC+YSM+DVRR FLGP+AH++GP +Q
Sbjct: 306 DELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQ 365

Query: 364 WVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 423
           WV YQGRVPYPRPG CPSKTFG F STKD PDDVI FAR+HP MYN V P   RP+ ++ 
Sbjct: 366 WVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKT 425

Query: 424 GANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED 483
             NY FTQI  DRV A DG YDV+FIGTDVGTVLKV+S+PK +    E +LLEE+ VF +
Sbjct: 426 DVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFRE 485

Query: 484 SAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRF 543
             A+++M++S+K+ QLY+ S + VAQ+ LHRC  +G+ C ECCLARDPYCAWDG AC+R+
Sbjct: 486 PTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRY 545

Query: 544 QPSAKRRFRRQDVRNGDPSTLCSG---DSSRPALLEHK-VFGVEGSSAFLECEPRSLQAR 599
            P+AKRR RRQD+RNGDP T CS    D+      E + ++GVE SS FLEC P+S +A 
Sbjct: 546 FPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRAL 605

Query: 600 VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL 659
           V W FQR       ++  ++   RT +GLLLR L+++DSG YLC AVE GF Q L +++L
Sbjct: 606 VYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTL 665

Query: 660 HVLSATQAERL---------ARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSL---- 706
            V+     E L         ++ +E + +  P  K+WYRDF+QL+      + +      
Sbjct: 666 EVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQV 725

Query: 707 -----RMCRPQP------ALQSLPLESRRKGRNRRTHAPEPRAERGPRS 744
                +  R +P      + +   L+  +KGRNRRTH      ER PRS
Sbjct: 726 WKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTH----EFERAPRS 770


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  679 bits (1752), Expect = 0.0
 Identities = 345/753 (45%), Positives = 489/753 (64%), Gaps = 26/753 (3%)

Query: 7   AAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEERG 65
           A ++  + +L+    G+   + PRL+L++++L   +    F        +Q LL+DEERG
Sbjct: 21  ALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERG 80

Query: 66  RLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNR 125
           RL +GA++H+  L+L +++K  KK+ WPA  E  E C  AGKD  TEC NF+++L  YN+
Sbjct: 81  RLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNK 140

Query: 126 THLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
           TH+  CGTGAFHP C ++++G   E+ + +LD   +E G+ K P+DP+   ASV+  E L
Sbjct: 141 THIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYL 200

Query: 186 YSGVAADLMGRDFTIFRSLG---QRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKI 242
           YSG A+D +G+D    RSLG       +RT+  +  WLN  KF+  F+IP++ NPDDDKI
Sbjct: 201 YSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKI 260

Query: 243 YFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-D 301
           YFFFRE++ E + +  +  +SRVG++C+NDVGGQRSL+NKWTTFLKARL+CS+PG +G D
Sbjct: 261 YFFFRESSQEGSTS-DKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGAD 319

Query: 302 THFDQLQDVFLLSSRDHRTPLLYAVF-STSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP 360
           T+FD+LQD++LL +RD R P++Y VF +TSSIF+GSAVCVYSM D+R  F GP+AHKE  
Sbjct: 320 TYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESA 379

Query: 361 MHQWVSYQGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419
            H+WV Y GR+PYPRPG CPSKT+     ST+DFPDDVI F + H +MY SV P  G P 
Sbjct: 380 DHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPT 439

Query: 420 FLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELH 479
           F ++  +Y  TQI  D V A DG YDV+F+GTD+GTVLKV+S+ K  + + E ++LEEL 
Sbjct: 440 FKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISK-EKWNMEEVVLEELQ 498

Query: 480 VFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA 539
           +F+ S+ + +M++S K+ QLY+ SR  + Q++LHRC  +G+ C +CCLARDPYCAWDG A
Sbjct: 499 IFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNA 558

Query: 540 CTRFQPSAKRRFRRQDVRNGDPSTLC---SGDSSRPALLEHKVFGVEGSSAFLECEPRSL 596
           C+R+ P++KRR RRQDV+ GDP T C       S     E  +FG+E +S FLEC P+S 
Sbjct: 559 CSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQ 618

Query: 597 QARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRR 656
           QA ++W  QR+G     ++  +ER  +T  GLL+R L+++DSG+Y C A E  F   + +
Sbjct: 619 QATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVK 678

Query: 657 LSLHVLSATQAERLARAEEAAPAAP---PGPKLWYRDFLQLVEPGGGGSANSLRMCRPQP 713
           L+L+V+   Q E   RAE             +L Y+D++Q++        +S      Q 
Sbjct: 679 LTLNVIENEQMENTQRAEHEEGKVKDLLAESRLRYKDYIQIL--------SSPNFSLDQY 730

Query: 714 ALQSLPLESRR---KGRNRRTHAPEPRAERGPR 743
             Q    E RR   KG  +  H  E + +R  R
Sbjct: 731 CEQMWHREKRRQRNKGGPKWKHMQEMKKKRNRR 763


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  672 bits (1735), Expect = 0.0
 Identities = 374/791 (47%), Positives = 498/791 (62%), Gaps = 72/791 (9%)

Query: 9   VIPGLALLWAVGLGSAAPS---------PPRLRLSFQELQAWHGLQTFS-LERTCCYQAL 58
           ++ GL LLWA  L  A PS          PR+RLSF+EL+A      F+ L  T  Y+ L
Sbjct: 2   LVAGL-LLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL 60

Query: 59  LVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVK 118
           L DE+  R++VG++++V SL+L +I++    + W A  +  EEC  +GKD+  EC NFV+
Sbjct: 61  LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR 120

Query: 119 LLHAYNRTHLLACGTGAFHPTCAFVEVGHRAE---------------------------- 150
           L+  +NRTHL  CGTGA++P C +V  G RA+                            
Sbjct: 121 LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA 180

Query: 151 ---EPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQR 207
              + +  L+P R+E GKGK PYDP+   AS L+ EELY+GV  D MG D  IFR+LG++
Sbjct: 181 PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ 240

Query: 208 PSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEA--APALGRLSVSRV 265
            ++RT+ ++SRWLN+P F+    IP+S   +DDK+YFFFRE + EA  +PA+     +R+
Sbjct: 241 TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAV----YARI 296

Query: 266 GQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFDQLQDVFLLSSRDHRTPLLY 324
           G+IC ND GG   LVNKW+TFLKARLVCSVPG +G +THFD+LQDVF+  ++D R P++Y
Sbjct: 297 GRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIY 356

Query: 325 AVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKT 383
           AVF++S S+F+GSAVCVYSM D+R  F GPFAHKEGP +QW+ + G++PYPRPG CP  T
Sbjct: 357 AVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGT 416

Query: 384 FG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADG 442
           F  +  STKD+PD+VI F R+HPLMY +V P   RPL ++ GA Y  T IA D+V AADG
Sbjct: 417 FTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADG 476

Query: 443 HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVA 502
            Y+VLF+GTD GTV KVI +PK  +   E L+LEE+ VF+D A V +M ISSKR QLYVA
Sbjct: 477 RYEVLFLGTDRGTVQKVIVLPKDDQ-ELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVA 535

Query: 503 SRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPS 562
           S   V  ++LHRC A+G  C +CCLARDPYCAWDG AC+R+  S+KRR RRQDVR+G+P 
Sbjct: 536 SAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPI 595

Query: 563 TLCSG--DSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEER 620
             C G   ++    +E   +GV GS+AFLEC+PRS QA V+W FQR       ++ AE+R
Sbjct: 596 RQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDR 655

Query: 621 TERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLHVL--SATQAERLARAEEAAP 678
             RT +GLLLR L+  D G+Y C A E  F   + R+ LHVL   A  A        +AP
Sbjct: 656 FLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAP 715

Query: 679 ----AAPPGPKLWYRDFLQLVEPGGGGSANSL-----RMCRPQP-----ALQSLPLESRR 724
               A PP P   Y++  QL+     G  +       R   P P     A +S   + ++
Sbjct: 716 PPPGAGPPTPP--YQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQK 773

Query: 725 KGRNRRTHAPE 735
           K RNRR H P+
Sbjct: 774 KPRNRRHHPPD 784


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  662 bits (1707), Expect = 0.0
 Identities = 339/710 (47%), Positives = 460/710 (64%), Gaps = 41/710 (5%)

Query: 16  LWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQA---------LLVDEERGR 66
           LW  G  +A  + PRLRLS +EL         +L RT  + +         +L+DE + R
Sbjct: 19  LWTGG-HTADTTHPRLRLSHKEL--------LNLNRTSIFHSPFGFLDLHTMLLDEYQER 69

Query: 67  LFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRT 126
           LFVG  + V SL+L+ IS   K++ WP+     EEC   GKD G EC N+V++LH YNRT
Sbjct: 70  LFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRT 128

Query: 127 HLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELY 186
           HLL CGTGAF P CAF+ VG+  E+P+  L+  R E G+G+ P+DP     S L+G EL+
Sbjct: 129 HLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELF 188

Query: 187 SGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFF 246
           +G+ +D   RD  IFRS+G+   +RTE  D R L EPKFV  + IP++E+ DD+K+YFFF
Sbjct: 189 AGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFF 248

Query: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFD 305
            E A+EA      +  +RVG++C NDVGGQR LVNKW+TFLKARLVCSVPG+ G DT+FD
Sbjct: 249 TEKALEAENNAHAI-YTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFD 307

Query: 306 QLQDVFLLSSRDHRTPLLYAVFSTSS-IFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQW 364
           +L+DVFLL +RDH+ P+++ +F+T+S IF+G A+CVY M+ +R AF GP+AHKEGP + W
Sbjct: 308 ELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW 367

Query: 365 VSYQGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 423
             Y+G+VPYPRPG C SK  G  + +TKD+PDD I+FAR+HPLMY ++ P   +P+ ++ 
Sbjct: 368 SVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKT 427

Query: 424 GANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED 483
              Y   QIA DRV A DG YDVLFIGTD G VLKVI++      S E ++LEEL +F+D
Sbjct: 428 DGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKD 487

Query: 484 SAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRF 543
              + SM+ISSKR QLY+ S SAVAQ+  H C  +G  C +CCLARDPYCAWDG++C+R+
Sbjct: 488 PVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRY 547

Query: 544 QPS---AKRRFRRQDVRNGDPSTLCSGDSSRPALL----EHKVFGVEGSSAFLECEPRSL 596
            P+   AKRRFRRQDVR+G+ +  C G       L    EH  +G+E +S  LEC PRSL
Sbjct: 548 YPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRSL 607

Query: 597 QARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRR 656
           QA+V W  Q+   T   +V  ++R  +   GLL  RL + D+G Y C  VE  F   +R+
Sbjct: 608 QAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRK 667

Query: 657 LSLHVLSATQAERLARAEE-----------AAPAAPPGPKLWYRDFLQLV 695
           ++L V+   + E +   ++           A  +   G K WY++FLQL+
Sbjct: 668 ITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLI 717


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  659 bits (1699), Expect = 0.0
 Identities = 351/711 (49%), Positives = 457/711 (64%), Gaps = 32/711 (4%)

Query: 14  ALLWAVGL-----GSAAPSP----PRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEE 63
           A+ W +G      GS+ PSP    PRLRLS+++L + +    F   + +   QA+ +DE 
Sbjct: 7   AICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEY 66

Query: 64  RGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAY 123
           R RLF+G  + + SL LD      +++ WP     REEC   G+D  TEC NFV++L  +
Sbjct: 67  RDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPH 126

Query: 124 NRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE 183
           NRTHLLACGTGAF PTCA + VGHR E  VL L+PG +E G+G+ P++P    AS  +  
Sbjct: 127 NRTHLLACGTGAFQPTCALITVGHRGEH-VLHLEPGSVESGRGRCPHEPSRPFASTFIDG 185

Query: 184 ELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIY 243
           ELY+G+ AD +GR+  IFRS G RP+LR++  D   L++P+FV    IPE+ + D+DK+Y
Sbjct: 186 ELYTGLTADFLGREAMIFRSGGPRPALRSD-SDQSLLHDPRFVMAARIPENSDQDNDKVY 244

Query: 244 FFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DT 302
           FFF ET          ++VSRVG++C ND GGQR LVNKW+TFLKARLVCSVPG  G +T
Sbjct: 245 FFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAET 304

Query: 303 HFDQLQDVFLLSSRDHRTPLLYAVFST-SSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPM 361
           HFDQL+DVFLL  +  ++  +YA+FST S++FQG AVCVY M D+   F GPFAH++GP 
Sbjct: 305 HFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQ 364

Query: 362 HQWVSYQGRVPYPRPGMCPSKTFG----TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGR 417
           HQW  Y G+VP+PRPG+CPSK        F STKD+PD+V+QFAR HPLM+  V P  GR
Sbjct: 365 HQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGR 424

Query: 418 PLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEE 477
           P+ ++        QI  DRV A DG YDV+F+GTD G+VLKVI++  G     E ++LEE
Sbjct: 425 PVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEE 484

Query: 478 LHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDG 537
           L VF+    +T M+IS KR  LYV SR  VAQ+ LH+C  +G  C ECCLARDPYCAWDG
Sbjct: 485 LQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDG 544

Query: 538 VACTRFQPS-AKRRFRRQDVRNGDPSTLCSGDSSRP----ALLEHKVFGVEGSSAFLECE 592
            +CT ++PS  KRRFRRQD+R+G+P+  C G S        +    V+G E +S FLEC 
Sbjct: 545 ASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECL 604

Query: 593 PRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQ 652
           P+S QA V W  QR G     QV  +ER   T RGLL RRL R D+G Y C  +E GF+Q
Sbjct: 605 PKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQ 664

Query: 653 PLRRLSLHVLSATQAERLARAEEAAPAAPPG--------PKLWYRDFLQLV 695
            + RL+L V+ A+Q + L    E  P  PP         PK WY+D LQL+
Sbjct: 665 TVVRLALVVIVASQLDNLF-PPEPKPEEPPARGGLASTPPKAWYKDILQLI 714


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  634 bits (1635), Expect = 0.0
 Identities = 317/649 (48%), Positives = 443/649 (68%), Gaps = 11/649 (1%)

Query: 22  GSAAPSPPRLRLSFQELQAWHGLQTFSLER-TCCYQALLVDEERGRLFVGAENHVASLNL 80
           GS+ P   R+ L+F EL+     + FSL      Y+ LL+DE++ R++VG+++H+ SLN+
Sbjct: 21  GSSQPQA-RVYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNI 79

Query: 81  DNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTC 140
           +NIS+ A  + WPA     EEC  AGKD    C NFV+++  +NRTHL  CG+GAF P C
Sbjct: 80  NNISQEALSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVC 139

Query: 141 AFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTI 200
            ++  G R+E+ V  +D  + E GKG+  ++P     SV++ EEL+SG+  D MG D  I
Sbjct: 140 TYLNRGRRSEDQVFMID-SKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAI 198

Query: 201 FRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRL 260
           FRSL +R ++RT+ H+S+WL+EP FV    IP+  +P+D K+YFFF+E   +   +  ++
Sbjct: 199 FRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQI 258

Query: 261 SVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFDQLQDVFLLSSRDHR 319
             S + +IC ND GG RSLVNKWTTFLKARLVCSV   +G +THFD+L+DVFLL + + R
Sbjct: 259 H-SMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPR 317

Query: 320 TPLLYAVFSTSS-IFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGM 378
           T L+Y +F+TSS +F+GSAVCVY ++D++  F GPFAHKEGP HQ +SYQGR+PYPRPG 
Sbjct: 318 TTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGT 377

Query: 379 CPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRV 437
           CP   F     +TK+FPDDV+ F RNHPLMYNS+ P   RPL +++G +Y +T+IA DRV
Sbjct: 378 CPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRV 437

Query: 438 AAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRH 497
            AADG Y VLF+GTD GTV KV+ +P  +  S E L+LEEL VF++ A +T+M+ISSK+ 
Sbjct: 438 NAADGRYHVLFLGTDRGTVQKVVVLPTNNSVSGE-LILEELEVFKNHAPITTMKISSKKQ 496

Query: 498 QLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVR 557
           QLYV+S   V+Q++LHRC  +G  C +CCLARDPYCAWDG +C+RF P+ KRR RRQDVR
Sbjct: 497 QLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVR 556

Query: 558 NGDPSTLCSGDSSRP--ALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQV 615
           +G+P T C G + +      E   +GV+ ++ FLEC P+S QA ++W  Q+       +V
Sbjct: 557 HGNPLTQCRGFNLKAYRNAAEIVQYGVKNNTTFLECAPKSPQASIKWLLQK-DKDRRKEV 615

Query: 616 LAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLHVLSA 664
              ER   T++GLL+R ++  D G+Y C A E  F Q + +++  VL +
Sbjct: 616 KLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDS 664


>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score =  344 bits (883), Expect = 2e-94
 Identities = 230/650 (35%), Positives = 329/650 (50%), Gaps = 42/650 (6%)

Query: 14  ALLWAVGLGSAA--PSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGA 71
           A LW +G+G+       PR  +S  EL     ++ FS      +  L + E  G L+VGA
Sbjct: 12  ARLWGLGIGAEVWWNLVPRKTVSSGELATV--VRRFSQTGIQDFLTLTLTEPTGLLYVGA 69

Query: 72  ENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLAC 131
              + + +++ +  +   ++W APVE + EC   GK+  TEC NF++ L  YN +HL  C
Sbjct: 70  REALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVC 128

Query: 132 GTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAA 191
           GT AF P C +V +          L+ G  EDGKGK PYDP    A +LV  ELYS    
Sbjct: 129 GTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLN 182

Query: 192 DLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENP---DDDKIYFFFRE 248
           + +G +  I R++G   S++TE + + WLNEP FV   ++PES      DDDK+YFFFRE
Sbjct: 183 NFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRE 241

Query: 249 TAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQ 308
            AVE +       V+RV ++C+ D+GG R+L  KWTTFLKARL CS P  +   +F+QLQ
Sbjct: 242 RAVE-SDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQ--LYFNQLQ 298

Query: 309 DVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSY 367
            +  L          + VF         SA+C Y + +++R F GP+        +W  Y
Sbjct: 299 AMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY 358

Query: 368 QGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGA 425
              VP PRPG C +       ++S+ + PD+++ F + HPLM   V P   RPL ++ G 
Sbjct: 359 TDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGT 418

Query: 426 NYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDS 484
           N  FT + ADRV   DG  Y VLFIGT  G +LK +S+           L+EEL +F D 
Sbjct: 419 N--FTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVH------LIEELQLF-DQ 469

Query: 485 AAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQ 544
             + S+ +S  +  L+  SRS + Q+ +  C  + R C +C LARDPYCAW  V  +R  
Sbjct: 470 EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYCAW-SVNTSRCV 527

Query: 545 P--SAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHK-VFGVEGSSAFLECEPRSLQARVE 601
                      Q V   D S +C+   S+      K +  V G+   L C   S  A   
Sbjct: 528 AVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHAR 587

Query: 602 WTFQRAGVTAHT--QVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQG 649
           WTF    + A      L + R +     L++   + R +G Y C + EQG
Sbjct: 588 WTFGGRDLPAEQPGSFLYDARLQ----ALVVMAAQPRHAGAYHCFSEEQG 633


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  343 bits (881), Expect = 3e-94
 Identities = 235/655 (35%), Positives = 345/655 (52%), Gaps = 48/655 (7%)

Query: 10  IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFV 69
           I GL +  AV  G+A    P  R++++  +    L  F       Y ALL+ E++  L++
Sbjct: 7   IRGLLMALAVMFGTAMAFAPIPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYI 64

Query: 70  GAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLL 129
           GA   V ++N  NIS++  ++ W    + + +C   GK   TEC+N++++L   + T L 
Sbjct: 65  GAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLY 124

Query: 130 ACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGV 189
            CGT AF P C  + +        L    G+ EDGKG+ P+DP H   SV+V  ELYSG 
Sbjct: 125 VCGTNAFQPACDHLNL---TSFKFL----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGT 177

Query: 190 AADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI---PESENPDDDKIYFFF 246
           + + +G +  I R+    P LRTE +   WLNEP FV    I   P+S + +DD++YFFF
Sbjct: 178 SYNFLGSEPIISRNSSHSP-LRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFF 235

Query: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQ 306
            E +VE    + R+ + R+ ++C+ D GG R+L  KWT+FLKARL+CS P  +    F+ 
Sbjct: 236 TEVSVE-YEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP--DSGLVFNV 292

Query: 307 LQDVFLLSSRDHRTPLLYAVFSTSSIFQG-SAVCVYSMNDVRRAFL-GPFAHK---EGPM 361
           L+DVF+L S   + P+ YA+F+      G SAVC Y+++     F  G +      E   
Sbjct: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352

Query: 362 HQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419
            +WV Y G VP PRPG C         ++S+ + PD  +QF ++HPLM +SV P   RP 
Sbjct: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412

Query: 420 FLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEEL 478
            ++   NY  TQI  DR  A DG  YDV+F+ TD G + K IS+           ++EE 
Sbjct: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEET 464

Query: 479 HVFEDSAAVTSMQISSKRHQ--LYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 536
            +F+D   V ++ +SSK+    +Y  S S V Q  L  C  HG  C +C LARDPYCAW 
Sbjct: 465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWS 523

Query: 537 GVACT---RFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEP 593
               T     Q  +  R   Q++ +GD S +C  D S+ +  +H  F   G +A L+C  
Sbjct: 524 PPTATCVALHQTESPSRGLIQEM-SGDAS-VCP-DKSKGSYRQH--FFKHGGTAELKCSQ 578

Query: 594 RSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQ 648
           +S  ARV W FQ   + A     + +      + LL+  L   DSGVY C + E+
Sbjct: 579 KSNLARVFWKFQNGVLKAE----SPKYGLMGRKNLLIFNLSEGDSGVYQCLSEER 629


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  321 bits (822), Expect = 2e-87
 Identities = 211/579 (36%), Positives = 309/579 (53%), Gaps = 41/579 (7%)

Query: 10  IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFV 69
           I GL +  AV  G+A    P  R++++  +    L  F       Y ALL+ E++  L++
Sbjct: 7   IRGLLMALAVMFGTAMAFAPIPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYI 64

Query: 70  GAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLL 129
           GA   V ++N  NIS++  ++ W    + + +C   GK   TEC+N++++L   + T L 
Sbjct: 65  GAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLY 124

Query: 130 ACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGV 189
            CGT AF P C  + +        L    G+ EDGKG+ P+DP H   SV+V  ELYSG 
Sbjct: 125 VCGTNAFQPACDHLNL---TSFKFL----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGT 177

Query: 190 AADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI---PESENPDDDKIYFFF 246
           + + +G +  I R+    P LRTE +   WLNEP FV    I   P+S + +DD++YFFF
Sbjct: 178 SYNFLGSEPIISRNSSHSP-LRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFF 235

Query: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQ 306
            E +VE    + R+ + R+ ++C+ D GG R+L  KWT+FLKARL+CS P  +    F+ 
Sbjct: 236 TEVSVE-YEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP--DSGLVFNV 292

Query: 307 LQDVFLLSSRDHRTPLLYAVFSTSSIFQG-SAVCVYSMNDVRRAFL-GPFAHK---EGPM 361
           L+DVF+L S   + P+ YA+F+      G SAVC Y+++     F  G +      E   
Sbjct: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352

Query: 362 HQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419
            +WV Y G VP PRPG C         ++S+ + PD  +QF ++HPLM +SV P   RP 
Sbjct: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412

Query: 420 FLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEEL 478
            ++   NY  TQI  DR  A DG  YDV+F+ TD G + K IS+           ++EE 
Sbjct: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEET 464

Query: 479 HVFEDSAAVTSMQISSKRHQ--LYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 536
            +F+D   V ++ +SSK+    +Y  S S V Q  L  C  HG  C +C LARDPYCAW 
Sbjct: 465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWS 523

Query: 537 GVACT---RFQPSAKRRFRRQDVRNGDPSTLCSGDSSRP 572
               T     Q  +  R   Q++ +GD S +C   S +P
Sbjct: 524 PPTATCVALHQTESPSRGLIQEM-SGDAS-VCPASSPKP 560


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  319 bits (817), Expect = 7e-87
 Identities = 239/750 (31%), Positives = 351/750 (46%), Gaps = 75/750 (10%)

Query: 15  LLWAVGLGSAAPSP------------PRLRLSFQELQAWHGLQTFSLERTCCYQALLVDE 62
           LL ++   +A P P            PR+ + ++EL    G + F  +    Y  LL++E
Sbjct: 8   LLLSILTATAVPGPSLRRPSRELDATPRMTIPYEELS---GTRHFKGQAQN-YSTLLLEE 63

Query: 63  ERGRLFVGAENHVASLNLDNISKRA-KKLAWPAPVEWREECNWAGKDIGTECMNFVKLLH 121
              RL VGA   + SL+ ++I   A K++ W A  E + +C+  GK+  TEC N V+ L 
Sbjct: 64  ASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQ 123

Query: 122 AYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLV 181
             N THL ACGT AF P CA ++    AE   L   P   E+GK K PYDP      +++
Sbjct: 124 RLNSTHLYACGTHAFQPLCAAID----AEAFTL---PTSFEEGKEKCPYDPARGFTGLII 176

Query: 182 GEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENP---D 238
              LY+    +   R     R      SLRTE     WLN+ +FV    + ES+     D
Sbjct: 177 DGGLYTATRYEF--RSIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGD 234

Query: 239 DDKIYFFFRETAVEAAPALGRLS-----VSRVGQICRNDVGGQRSLVNKWTTFLKARLVC 293
           DDK+Y+FF E A E        S     V+RV ++C+ D+GG++ L  KWT+FLKARL+C
Sbjct: 235 DDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLIC 294

Query: 294 SVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTSS---IFQGSAVCVYSMNDVRRAF 350
            +P       ++ L+ V  L +        YA F+ S+     + SA+C Y + +++  F
Sbjct: 295 HIP------LYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVF 348

Query: 351 LGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMY 408
            GP+   +    +W  Y+G VP PRPG C + +  +  ++S++D P  V+ F + HPLM 
Sbjct: 349 AGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMA 408

Query: 409 NSVLPTGGRPLFLQVGANYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSR 467
             V+PT GRPL L+   N  +T +    V    G  YD+LF+GT  G + K + +  G  
Sbjct: 409 RPVVPTRGRPLLLK--RNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSGMH 466

Query: 468 PSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCL 527
                 ++EE  VF +S +V ++ IS  +H LYV + S V Q+ L  C+ + R C +C L
Sbjct: 467 ------IIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRY-RSCYDCIL 519

Query: 528 ARDPYCAWDG-----VACTRF--QPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVF 580
           ARDPYC WD       A T    +    R    QD+  G+     S D+  P  L+ +  
Sbjct: 520 ARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRGCESSRDTGPPPPLKTRSV 579

Query: 581 GVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGV 640
            + G    L C+  S  AR  W    +   +  Q       +    GLL+   +   SG 
Sbjct: 580 -LRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVD----GLLVTDAQPEHSGN 634

Query: 641 YLCAAVEQGFTQPLRRLSLHVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGG 700
           Y C A E G    L   SL V  AT A         AP AP  P       ++L+     
Sbjct: 635 YGCYAEENGLRTLLASYSLTVRPATPA--------PAPKAPATPGAQLAPDVRLLYVLAI 686

Query: 701 GSANSLRMCRPQPALQSLPLESRRKGRNRR 730
            +   L +      L    L   R+GR R+
Sbjct: 687 AALGGLCLILASSLLYVACLREGRRGRRRK 716


>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  314 bits (804), Expect = 2e-85
 Identities = 215/589 (36%), Positives = 303/589 (51%), Gaps = 47/589 (7%)

Query: 5   GAAAVIPGLALLWAVGLGSAAPSP-----PRLRLSFQELQAWHGLQTFSLERTCCYQALL 59
           GA    P L LL  + L    P P     PR+ L     +       F  E    Y ALL
Sbjct: 17  GALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEE--RPFLRFEAEHISNYTALL 74

Query: 60  VDEERGRLFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115
           +  +   L+VGA   + +L+  N+S       ++L W A  E +++C++ GKD   +C N
Sbjct: 75  LSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQN 133

Query: 116 FVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRI--EDGKGKSPYDPR 173
           ++K+L   + +HL  CGT AF P C ++ + +     + R + G +  EDGKG+ P+DP 
Sbjct: 134 YIKILLPLSGSHLFTCGTAAFSPMCTYINMENFT---LARDEKGNVLLEDGKGRCPFDPN 190

Query: 174 HRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPE 233
            ++ +++V  ELY+G  +   G D  I RS   RP+ +TE     WL +P FV   +IPE
Sbjct: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTE-SSLNWLQDPAFVASAYIPE 248

Query: 234 SENP---DDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKAR 290
           S      DDDKIYFFF ET  E         VSR+ +IC+ D GG+R L  +WT+FLKA+
Sbjct: 249 SLGSLQGDDDKIYFFFSETGQE-FEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQ 307

Query: 291 LVCSVPGVEGDTHFDQLQDVFLL--SSRDHRTPLLYAVFSTS---SIFQGSAVCVYSMND 345
           L+CS P  +    F+ LQDVF L  S +D R  L Y VF++       +GSAVCV++M D
Sbjct: 308 LLCSRP--DDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365

Query: 346 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARN 403
           V+R F G +        QW +    VP PRPG C   S      +S+   PD V+ F ++
Sbjct: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425

Query: 404 HPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVP 463
           H LM   V     R L LQ  A Y   ++A  RV      YDVLF+GT  G + K +SV 
Sbjct: 426 HFLMDGQV---RSRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSV- 479

Query: 464 KGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCT 523
            G R      ++EEL +F     V ++ + + R  LY AS S V Q+ +  C+ + R C 
Sbjct: 480 -GPRVH----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533

Query: 524 ECCLARDPYCAWDGVAC---TRFQPSAKRRFRRQDVRNGDPSTLCSGDS 569
           +C LARDPYCAW G +C   + +QP    R   QD+       LCS  S
Sbjct: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASS 582


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  314 bits (804), Expect = 2e-85
 Identities = 215/589 (36%), Positives = 303/589 (51%), Gaps = 47/589 (7%)

Query: 5   GAAAVIPGLALLWAVGLGSAAPSP-----PRLRLSFQELQAWHGLQTFSLERTCCYQALL 59
           GA    P L LL  + L    P P     PR+ L     +       F  E    Y ALL
Sbjct: 17  GALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEE--RPFLRFEAEHISNYTALL 74

Query: 60  VDEERGRLFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115
           +  +   L+VGA   + +L+  N+S       ++L W A  E +++C++ GKD   +C N
Sbjct: 75  LSRDGRTLYVGAREALFALS-SNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQN 133

Query: 116 FVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRI--EDGKGKSPYDPR 173
           ++K+L   + +HL  CGT AF P C ++ + +     + R + G +  EDGKG+ P+DP 
Sbjct: 134 YIKILLPLSGSHLFTCGTAAFSPMCTYINMENFT---LARDEKGNVLLEDGKGRCPFDPN 190

Query: 174 HRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPE 233
            ++ +++V  ELY+G  +   G D  I RS   RP+ +TE     WL +P FV   +IPE
Sbjct: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTE-SSLNWLQDPAFVASAYIPE 248

Query: 234 SENP---DDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKAR 290
           S      DDDKIYFFF ET  E         VSR+ +IC+ D GG+R L  +WT+FLKA+
Sbjct: 249 SLGSLQGDDDKIYFFFSETGQE-FEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQ 307

Query: 291 LVCSVPGVEGDTHFDQLQDVFLL--SSRDHRTPLLYAVFSTS---SIFQGSAVCVYSMND 345
           L+CS P  +    F+ LQDVF L  S +D R  L Y VF++       +GSAVCV++M D
Sbjct: 308 LLCSRP--DDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365

Query: 346 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARN 403
           V+R F G +        QW +    VP PRPG C   S      +S+   PD V+ F ++
Sbjct: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425

Query: 404 HPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVP 463
           H LM   V     R L LQ  A Y   ++A  RV      YDVLF+GT  G + K +SV 
Sbjct: 426 HFLMDGQV---RSRMLLLQPQARY--QRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSV- 479

Query: 464 KGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCT 523
            G R      ++EEL +F     V ++ + + R  LY AS S V Q+ +  C+ + R C 
Sbjct: 480 -GPRVH----IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCG 533

Query: 524 ECCLARDPYCAWDGVAC---TRFQPSAKRRFRRQDVRNGDPSTLCSGDS 569
           +C LARDPYCAW G +C   + +QP    R   QD+       LCS  S
Sbjct: 534 DCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASS 582


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  303 bits (775), Expect = 5e-82
 Identities = 191/538 (35%), Positives = 277/538 (51%), Gaps = 50/538 (9%)

Query: 65  GRLFVGAENHVASLNLDNISKR----AKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL 120
           G L++ A +H+ ++++D         +KKL W +     + C   GK    EC NF+K+L
Sbjct: 66  GTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKH-KDECHNFIKVL 124

Query: 121 HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDP-GRIEDGKGKSPYDPRHRAASV 179
              N   L  CGT AF+P+C   ++          L+P G    G  + PYD +H   ++
Sbjct: 125 LKKNDDALFVCGTNAFNPSCRNYKMD--------TLEPFGDEFSGMARCPYDAKHANVAL 176

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS    D +  D  I+RSLG+ P+LRT  HDS+WL EP FV+            
Sbjct: 177 FADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAV-------DYG 229

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           D IYFFFRE AVE    +G++   RV Q+C+ND+GG QR L  +WT+FLKARL CSVP  
Sbjct: 230 DYIYFFFREIAVE-YNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVP-- 286

Query: 299 EGDTHF-----DQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLG 352
            GD+HF       + DV  ++ RD    ++ A FST  +   GSAVC Y M D+   F G
Sbjct: 287 -GDSHFYFNILQAVTDVIRINGRD----VVLATFSTPYNSIPGSAVCAYDMLDIASVFTG 341

Query: 353 PFAHKEGPMHQWVSY-QGRVPYPRPGMCP-SKTFGTFSSTKDFPDDVIQFARNHPLMYNS 410
            F  ++ P   W      RVP PRPG C  S +   ++++ +FPDD + F + HPLM  +
Sbjct: 342 RFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEA 401

Query: 411 VLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA 470
           V     RP FL+    Y  T+IA D  A    ++ V+F+G++ G +LK ++    S    
Sbjct: 402 VPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLN 461

Query: 471 EGLLLEELHVFE---------DSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRV 521
           + L LEE+ V+          +   +  MQ+      LYVA  + V ++ L RC  HG+ 
Sbjct: 462 DSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKC 521

Query: 522 CTECCLARDPYCAW--DGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEH 577
              C  +RDPYC W  +G AC+   P+++  F  QD+  G+   L    +S  AL  H
Sbjct: 522 KKTCIASRDPYCGWIKEGGACSHLSPNSRLTF-EQDIERGNTDGLGDCHNSFVALNGH 578


>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score =  297 bits (760), Expect = 3e-80
 Identities = 202/651 (31%), Positives = 318/651 (48%), Gaps = 63/651 (9%)

Query: 20  GLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLN 79
           G G   P P   R+ +        L  F  +    +  LL+  +   L+VGA   + +L+
Sbjct: 32  GGGGQGPMP---RVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALD 88

Query: 80  LDN--ISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFH 137
           + +  + +    + WPA    + EC +  K   T+C NF+++L +YN THL  CGT AF 
Sbjct: 89  IQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFS 148

Query: 138 PTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRD 197
           P C F+E+    +  +L +   ++ +GKG+SP+DP H+  +VLV   LYSG   + +G +
Sbjct: 149 PACTFIEL---QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSE 205

Query: 198 FTIFRSLGQRPSLRTEPHDSRWLN-EPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPA 256
             + R+LG +P L+T+ +  RWL+ +  FV          P    +YFFF ETA E    
Sbjct: 206 PILMRTLGSQPVLKTD-NFLRWLHHDASFVAAI-------PSTQVVYFFFEETASEF-DF 256

Query: 257 LGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSR 316
             RL  SRV ++C+NDVGG++ L  KWTTFLKA+L+C+ P   G   F+ ++   LL + 
Sbjct: 257 FERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQP---GQLPFNVIRHAVLLPAD 313

Query: 317 DHRTPLLYAVFSTSSIFQG---SAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPY 373
               P +YAVF++     G   SAVC +S+ D+ R F G +        +W +Y+G    
Sbjct: 314 SPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETN 373

Query: 374 PRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIA 433
           PRPG C         S     D  + F ++H LM   V+   G PL ++ G  Y  T++A
Sbjct: 374 PRPGSC---------SVGPSSDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLA 419

Query: 434 ADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQI 492
            +     DGH + V+++GT  G++ K +     S       L+EE+ +F D   V ++Q+
Sbjct: 420 VETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSS-----AHLVEEIQLFPDPEPVRNLQL 474

Query: 493 SSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKR-RF 551
           +  +  ++V     V ++    C+ +   C +C LARDP+CAWD  + T    SA     
Sbjct: 475 APTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPNLNS 533

Query: 552 RRQDVRNGDPSTLCSG--------DSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWT 603
            +QD+  G+P   C+           SRP +++ +V  V  S   L C   S  A   W 
Sbjct: 534 WKQDMERGNPEWACASGPMSRSLRPQSRPQIIK-EVLAVPNSILELPCPHLSALASYYW- 591

Query: 604 FQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPL 654
                  +H      E +     G LL  ++    G+Y C A E GF+ P+
Sbjct: 592 -------SHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPV 635


>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score =  293 bits (750), Expect = 4e-79
 Identities = 213/616 (34%), Positives = 311/616 (50%), Gaps = 47/616 (7%)

Query: 13  LALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAE 72
           LA+L     G    S PR  L   E  +   L  F++  T  Y  LLVD     L+VGA 
Sbjct: 25  LAVLSGPVSGRVPRSVPRTSLPISEADSC--LTRFAVPHTYNYSVLLVDPASHTLYVGAR 82

Query: 73  NHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACG 132
           + + +L+L    +R +++ W  P   R+ C   GK    EC NFV++L   N +HLL CG
Sbjct: 83  DTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKK-EDECHNFVQILAIANASHLLTCG 141

Query: 133 TGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAAD 192
           T AF P C  ++V    +         R+E G+GK P++P  R+A+V+ G  LY+    +
Sbjct: 142 TFAFDPKCGVIDVSRFQQVE-------RLESGRGKCPFEPAQRSAAVMAGGVLYAATVKN 194

Query: 193 LMGRDFTIFRSLGQRPS-LRTEPHDSRWLNEPKFVKVFWIPESENPD---DDKIYFFFRE 248
            +G +  I R++G+    +RT+   S WLN P FV    +  +E  D   DD+IYFFF E
Sbjct: 195 YLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTE 253

Query: 249 TAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQ 308
           T+  A  +  R+ V RV ++C  D+GG+++L  +WTTFLKA L+C  PG E       LQ
Sbjct: 254 TS-RAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLC--PGPEHGRASSVLQ 310

Query: 309 DVFLLSSR-DHRTPLLYAVFSTSSIFQG---SAVCVYSMNDVRRAFLGPFAHKEGPMHQW 364
           DV +L       TP+ Y +F  SS ++G   SAVC +   D+R    GPF   +   ++ 
Sbjct: 311 DVAVLRPELGAGTPIFYGIF--SSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRG 368

Query: 365 VS-YQGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFL 421
           +      VP PRPG C +       F S+   PD V+ F R+HPLM   V P  G PL  
Sbjct: 369 LPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLL- 427

Query: 422 QVGANYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHV 480
            V  +  + ++ A RV +  G  YDVL++GT+ G + + +      R  A+  +LE+L +
Sbjct: 428 -VTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAV------RIGAQLSVLEDLAL 480

Query: 481 FEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRV--CTECCLARDPYCAWDGV 538
           F +   V +M++      L V SR+ V Q+    C   GR+  C+EC LA+DP CAW   
Sbjct: 481 FPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNC---GRLQSCSECILAQDPVCAWSFR 535

Query: 539 ACTRFQPSAKRRFRRQDVRNGDPSTLCSGD-SSRPALLEHKVFGVEGSSAFLECEPRSLQ 597
                  + + R   QD+ + D S+LC  +   RP + E  V     +   L C P S  
Sbjct: 536 LDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPV--ATAAHVVLPCSPSSAW 593

Query: 598 ARVEWTFQRAGVTAHT 613
           A   W  Q +GVTA T
Sbjct: 594 ASCVW-HQPSGVTALT 608


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  285 bits (729), Expect = 1e-76
 Identities = 185/539 (34%), Positives = 273/539 (50%), Gaps = 41/539 (7%)

Query: 64  RGRLFVGAENHVASLNLDNISKRA----KKLAWPAPVEWREECNWAGKDIGTECMNFVKL 119
           R  L++   + V ++NL+ + K      KKL W +  + RE C   GK    EC NF+K+
Sbjct: 66  RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124

Query: 120 LHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASV 179
               N   +  CGT AF+P C +  +        L  D   I  G  + P+D R    ++
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS------TLEYDGEEIS-GLARCPFDARQTNVAL 177

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS   AD +  D  I+RS+G   +LRT  +DS+W+ EP F+             
Sbjct: 178 FADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY-------G 230

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           + +YFFFRE AVE    LG+   SRV +IC+ND+GG QR L   WT+FLKARL CSVPG 
Sbjct: 231 NYVYFFFREIAVEHNN-LGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG- 288

Query: 299 EGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHK 357
           +   +FD LQ +  +  + +  P +  VF+T  +   GSAVC +SM+D+ + F G F  +
Sbjct: 289 DSFFYFDVLQSITDII-QINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 EGPMHQWVSY-QGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTG 415
           + P   W +  + +VP PRPG C        + ++ DFPD+ + F ++HPLM ++V P  
Sbjct: 348 KTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA 407

Query: 416 GRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA-EGLL 474
             P F +    Y  T I+ D  A    +Y V+F+G++ G VLKV++  K S  S  + +L
Sbjct: 408 DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSLNDSVL 465

Query: 475 LEELHVF---------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
           LEE+  +         E+   V S+Q+    H LYVA  S + +I L RC  +G     C
Sbjct: 466 LEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSC 525

Query: 526 CLARDPYCAW-DGVACTRFQPSAKRRFRRQDVRNGDPSTL--CSGDSSRPALLEHKVFG 581
             +RDPYC W    +C R  P        QD   G+ + L  C          ++K+FG
Sbjct: 526 IASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFG 584


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  285 bits (729), Expect = 1e-76
 Identities = 185/539 (34%), Positives = 273/539 (50%), Gaps = 41/539 (7%)

Query: 64  RGRLFVGAENHVASLNLDNISKRA----KKLAWPAPVEWREECNWAGKDIGTECMNFVKL 119
           R  L++   + V ++NL+ + K      KKL W +  + RE C   GK    EC NF+K+
Sbjct: 66  RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124

Query: 120 LHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASV 179
               N   +  CGT AF+P C +  +        L  D   I  G  + P+D R    ++
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS------TLEYDGEEIS-GLARCPFDARQTNVAL 177

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS   AD +  D  I+RS+G   +LRT  +DS+W+ EP F+             
Sbjct: 178 FADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY-------G 230

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           + +YFFFRE AVE    LG+   SRV +IC+ND+GG QR L   WT+FLKARL CSVPG 
Sbjct: 231 NYVYFFFREIAVEHNN-LGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG- 288

Query: 299 EGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHK 357
           +   +FD LQ +  +  + +  P +  VF+T  +   GSAVC +SM+D+ + F G F  +
Sbjct: 289 DSFFYFDVLQSITDII-QINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 EGPMHQWVSY-QGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTG 415
           + P   W +  + +VP PRPG C        + ++ DFPD+ + F ++HPLM ++V P  
Sbjct: 348 KTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA 407

Query: 416 GRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA-EGLL 474
             P F +    Y  T I+ D  A    +Y V+F+G++ G VLKV++  K S  S  + +L
Sbjct: 408 DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSLNDSVL 465

Query: 475 LEELHVF---------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
           LEE+  +         E+   V S+Q+    H LYVA  S + +I L RC  +G     C
Sbjct: 466 LEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSC 525

Query: 526 CLARDPYCAW-DGVACTRFQPSAKRRFRRQDVRNGDPSTL--CSGDSSRPALLEHKVFG 581
             +RDPYC W    +C R  P        QD   G+ + L  C          ++K+FG
Sbjct: 526 IASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFG 584


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  283 bits (725), Expect = 3e-76
 Identities = 183/525 (34%), Positives = 268/525 (51%), Gaps = 41/525 (7%)

Query: 64  RGRLFVGAENHVASLNLDNISKRA----KKLAWPAPVEWREECNWAGKDIGTECMNFVKL 119
           R  L++   + V ++NL+ + K      KKL W +  + RE C   GK    EC NF+K+
Sbjct: 66  RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124

Query: 120 LHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASV 179
               N   +  CGT AF+P C +  +        L  D   I  G  + P+D R    ++
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS------TLEYDGEEIS-GLARCPFDARQTNVAL 177

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS   AD +  D  I+RS+G   +LRT  +DS+W+ EP F+             
Sbjct: 178 FADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY-------G 230

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           + +YFFFRE AVE    LG+   SRV +IC+ND+GG QR L   WT+FLKARL CSVPG 
Sbjct: 231 NYVYFFFREIAVEHNN-LGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG- 288

Query: 299 EGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHK 357
           +   +FD LQ +  +  + +  P +  VF+T  +   GSAVC +SM+D+ + F G F  +
Sbjct: 289 DSFFYFDVLQSITDII-QINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 EGPMHQWVSY-QGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTG 415
           + P   W +  + +VP PRPG C        + ++ DFPD+ + F ++HPLM ++V P  
Sbjct: 348 KTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA 407

Query: 416 GRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA-EGLL 474
             P F +    Y  T I+ D  A    +Y V+F+G++ G VLKV++  K S  S  + +L
Sbjct: 408 DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSLNDSVL 465

Query: 475 LEELHVF---------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
           LEE+  +         E+   V S+Q+    H LYVA  S + +I L RC  +G     C
Sbjct: 466 LEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSC 525

Query: 526 CLARDPYCAW-DGVACTRFQPSAKRRFRRQDVRNGDPSTL--CSG 567
             +RDPYC W    +C R  P        QD   G+ + L  C G
Sbjct: 526 IASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHG 570


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  283 bits (724), Expect = 4e-76
 Identities = 181/520 (34%), Positives = 266/520 (51%), Gaps = 39/520 (7%)

Query: 64  RGRLFVGAENHVASLNLDNISKRA----KKLAWPAPVEWREECNWAGKDIGTECMNFVKL 119
           R  L++   + V ++NL+ + K      KKL W +  + RE C   GK    EC NF+K+
Sbjct: 66  RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124

Query: 120 LHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASV 179
               N   +  CGT AF+P C +  +        L  D   I  G  + P+D R    ++
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS------TLEYDGEEIS-GLARCPFDARQTNVAL 177

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS   AD +  D  I+RS+G   +LRT  +DS+W+ EP F+             
Sbjct: 178 FADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY-------G 230

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           + +YFFFRE AVE    LG+   SRV +IC+ND+GG QR L   WT+FLKARL CSVPG 
Sbjct: 231 NYVYFFFREIAVEHNN-LGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG- 288

Query: 299 EGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHK 357
           +   +FD LQ +  +  + +  P +  VF+T  +   GSAVC +SM+D+ + F G F  +
Sbjct: 289 DSFFYFDVLQSITDII-QINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 EGPMHQWVSY-QGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTG 415
           + P   W +  + +VP PRPG C        + ++ DFPD+ + F ++HPLM ++V P  
Sbjct: 348 KTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA 407

Query: 416 GRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA-EGLL 474
             P F +    Y  T I+ D  A    +Y V+F+G++ G VLKV++  K S  S  + +L
Sbjct: 408 DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSLNDSVL 465

Query: 475 LEELHVF---------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
           LEE+  +         E+   V S+Q+    H LYVA  S + +I L RC  +G     C
Sbjct: 466 LEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSC 525

Query: 526 CLARDPYCAW-DGVACTRFQPSAKRRFRRQDVRNGDPSTL 564
             +RDPYC W    +C R  P        QD   G+ + L
Sbjct: 526 IASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHL 565


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  280 bits (716), Expect = 3e-75
 Identities = 177/501 (35%), Positives = 260/501 (51%), Gaps = 39/501 (7%)

Query: 64  RGRLFVGAENHVASLNLDNISKRA----KKLAWPAPVEWREECNWAGKDIGTECMNFVKL 119
           R  L++   + V ++NL+ + K      KKL W +  + RE C   GK    EC NF+K+
Sbjct: 66  RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124

Query: 120 LHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASV 179
               N   +  CGT AF+P C +  +        L  D   I  G  + P+D R    ++
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS------TLEYDGEEIS-GLARCPFDARQTNVAL 177

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS   AD +  D  I+RS+G   +LRT  +DS+W+ EP F+             
Sbjct: 178 FADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY-------G 230

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           + +YFFFRE AVE    LG+   SRV +IC+ND+GG QR L   WT+FLKARL CSVPG 
Sbjct: 231 NYVYFFFREIAVEHNN-LGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG- 288

Query: 299 EGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHK 357
           +   +FD LQ +  +  + +  P +  VF+T  +   GSAVC +SM+D+ + F G F  +
Sbjct: 289 DSFFYFDVLQSITDII-QINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 EGPMHQWVSY-QGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTG 415
           + P   W +  + +VP PRPG C        + ++ DFPD+ + F ++HPLM ++V P  
Sbjct: 348 KTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA 407

Query: 416 GRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA-EGLL 474
             P F +    Y  T I+ D  A    +Y V+F+G++ G VLKV++  K S  S  + +L
Sbjct: 408 DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSLNDSVL 465

Query: 475 LEELHVF---------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
           LEE+  +         E+   V S+Q+    H LYVA  S + +I L RC  +G     C
Sbjct: 466 LEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSC 525

Query: 526 CLARDPYCAW-DGVACTRFQP 545
             +RDPYC W    +C R  P
Sbjct: 526 IASRDPYCGWLSQGSCGRVTP 546


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score =  272 bits (696), Expect = 7e-73
 Identities = 186/532 (34%), Positives = 273/532 (51%), Gaps = 47/532 (8%)

Query: 33  LSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAW 92
           ++F++LQ W  +  F+      +  L +D    +L VGA N++  L+L N+S   +   W
Sbjct: 106 VAFEDLQPW--VSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSL-LQATEW 162

Query: 93  PAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGH--RAE 150
            +  + R  C   GK    EC N+V++L    R  +  CGT AF P C   +VG+  R  
Sbjct: 163 ASSEDTRRSCQSKGKT-EEECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTI 220

Query: 151 EPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE-ELYSGVAADLMGRDFTIFRSLGQRPS 209
           E +         +G  + PYDPRH + +V+  + ELY+    D  GRD  I+RSLG  P 
Sbjct: 221 EKI---------NGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPP 271

Query: 210 LRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQIC 269
           LRT  ++S+WLNEP FV  + I           YFF RE AVE     GR   SRV ++C
Sbjct: 272 LRTAQYNSKWLNEPNFVAAYDIGLF-------AYFFLRENAVE--HDCGRTVYSRVARVC 322

Query: 270 RNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFST 329
           +NDVGG+  L + WTTF+KARL CS PG E   ++++LQ  F L  +D    L+Y VF+T
Sbjct: 323 KNDVGGRFLLEDTWTTFMKARLNCSRPG-EVPFYYNELQSAFHLPEQD----LIYGVFTT 377

Query: 330 S-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFS 388
           + +    SAVC ++++ + +AF GPF ++E P   W+     +P  + G  P        
Sbjct: 378 NVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPET-----G 432

Query: 389 STKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLF 448
             ++  +  +Q A+   LM  +V P    P   Q   +  F+ +  D V A D  Y VL+
Sbjct: 433 PNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQ--DSVRFSHLVVDLVQAKDTLYHVLY 490

Query: 449 IGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDS--AAVTSMQISSKRHQLYVASRSA 506
           IGT+ GT+LK +S    +  S  G  LEELHV        + S++I      L+V  R  
Sbjct: 491 IGTESGTILKALST---ASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDG 547

Query: 507 VAQIALHRCAAHGRVCTECCLARDPYCAWDG--VACTRFQPSAKRRFRRQDV 556
           V ++ L RCAA+ R    C  ARDPYC WDG    C+  + S+      Q++
Sbjct: 548 VLRVPLERCAAY-RSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  271 bits (693), Expect = 2e-72
 Identities = 195/596 (32%), Positives = 292/596 (48%), Gaps = 55/596 (9%)

Query: 10  IPGLALLWAVGLG---SAAPSPPRLRLSFQELQAWHGLQTF-SLERTCCYQALLVDEER- 64
           +P L LL  + L    +A P  P L L   +LQ    L  F  LE       L +D +R 
Sbjct: 8   MPLLLLLLLLSLPHTQAAFPQDP-LPLLISDLQGTSPLSWFRGLEDDAVAAELGLDFQRF 66

Query: 65  ----GRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWR----EECNWAGKDIGTECMNF 116
                 L V A +HV S +L    +  + L     + WR    E C   GK +  EC N+
Sbjct: 67  LTLNRTLLVAARDHVFSFDLQ-AEEEGEGLVPNKYLTWRSQDVENCAVRGK-LTDECYNY 124

Query: 117 VKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRA 176
           +++L  ++   LLACGT +F P C    +    +E       G    G+ + P+D     
Sbjct: 125 IRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQE-------GEELSGQARCPFDATQSN 177

Query: 177 ASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESEN 236
            ++     LYS  AAD    D  ++RSLG +P LR+  +DS+WL EP FV+         
Sbjct: 178 VAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQAL------- 230

Query: 237 PDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQ-RSLVNKWTTFLKARLVCSV 295
              D +YFFFRE +VE A  LGR+  SRV ++C+ D+GG  R+L   WT+FLK RL CSV
Sbjct: 231 EHGDHVYFFFREVSVEDA-RLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSV 289

Query: 296 PGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFST-SSIFQGSAVCVYSMNDVRRAFLGPF 354
           PG +   +FD LQ         H    L+ VF+T ++   GSAVC + ++++ R F G F
Sbjct: 290 PG-DSTFYFDVLQ-ALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKF 347

Query: 355 AHKEGPMHQWVSY-QGRVPYPRPGMCPS-KTFGTFSSTKDFPDDVIQFARNHPLMYNSVL 412
             +      W    + RVP PRPG C        FSS++D PDDV+ F + HPL+  +V 
Sbjct: 348 KEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVP 407

Query: 413 PTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEG 472
           P   +PL L + +    TQ+A D +A    +  V+F+G++ GTVLKV++ P G     E 
Sbjct: 408 PVTHQPL-LTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLT-PGGRSGGPEP 465

Query: 473 LLLEELHVF-----------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRV 521
           +LLEE+  +           + +  +  +++ ++ H+L+VA    +  + L RCA HG  
Sbjct: 466 ILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGAC 525

Query: 522 CTECCLARDPYCAW-DGVACTRFQPS----AKRRFRRQDVRNGDPSTLCSGDSSRP 572
              C  ++DPYC W     C   + S      +   ++ + +GD     +G  S P
Sbjct: 526 QRSCLASQDPYCGWHSSRGCVDIRGSGGTDVDQAGNQESMEHGDCQDGATGSQSGP 581


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  261 bits (668), Expect = 1e-69
 Identities = 180/526 (34%), Positives = 263/526 (50%), Gaps = 47/526 (8%)

Query: 67  LFVGAENHVASLNLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHA 122
           LF+G  +++  + L+  +    +  +KL W +       C   GK  G EC NFVK+L  
Sbjct: 77  LFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEG-ECRNFVKVLLL 135

Query: 123 YNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVG 182
            + + L  CG+ AF+P CA   +     +PV     G    G  + PYDP+H   ++   
Sbjct: 136 RDESTLFVCGSNAFNPVCANYSID--TLQPV-----GDNISGMARCPYDPKHANVALFSD 188

Query: 183 EELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFV-KVFWIPESENPDDDK 241
             L++    D +  D  I+RSLG RP+LRT  HDS+W  EP FV  V W           
Sbjct: 189 GMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEW--------GSH 240

Query: 242 IYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQ-RSLVNKWTTFLKARLVCSVPGVEG 300
           +YFFFRE A+E    L ++ VSRV ++C+NDVGG  R L  +WT+FLKARL CSVPG + 
Sbjct: 241 VYFFFREIAME-FNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPG-DS 298

Query: 301 DTHFDQLQDVFLLSSRDHRTPLLYAVFST-SSIFQGSAVCVYSMNDVRRAFLGPFAHKEG 359
             +F+ LQ V  + S   R P++ AVFST S+   GSAVC + +  V   F G F  ++ 
Sbjct: 299 HFYFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKS 357

Query: 360 PMHQWVSY-QGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRP 418
           P   W    + +VP PRPG C +     ++++   PDD++ F + HPLM  +V   G  P
Sbjct: 358 PESIWTPVPEDQVPRPRPGCCAAPGM-QYNASSALPDDILNFVKTHPLMDEAVPSLGHAP 416

Query: 419 LFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGL--LLE 476
             L+    +  T++A D  A   G+  V+F+G++ GTVLK +  P  S     GL   LE
Sbjct: 417 WILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLE 476

Query: 477 ELHVF-----------EDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
           E   +           E    + S+++ +    L  A    V ++ + RC  +      C
Sbjct: 477 EFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNC 536

Query: 526 CLARDPYCAW--DGVACTRFQPSAKRRFRRQDVRNGDPSTL--CSG 567
             ++DPYC W  DG +C    P  +  F  QDV     S L  C+G
Sbjct: 537 IGSQDPYCGWAPDG-SCIFLSPGTRAAF-EQDVSGASTSGLGDCTG 580


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score =  248 bits (634), Expect = 1e-65
 Identities = 177/525 (33%), Positives = 266/525 (50%), Gaps = 54/525 (10%)

Query: 33  LSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAW 92
           +S++E+  W  L+ F  +    +  L  D  +  L VGA N++  L L+++S   + + W
Sbjct: 38  ISYKEIGPW--LREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEW 94

Query: 93  PAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEP 152
                 ++ C   GK    EC N++++L       L  CGT AF P C    + +  E  
Sbjct: 95  ECDEATKKACYSKGKS-KEECQNYIRVL-LVGGDRLFTCGTNAFTPVCTNRSLSNLTE-- 150

Query: 153 VLRLDPGRIED---GKGKSPYDPRHRAASVLV-GEELYSGVAADLMGRDFTIFRSLGQRP 208
                   I D   G  + PY P+H + ++L  G ELY+  A D  GRD  I+RSLG  P
Sbjct: 151 --------IHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILP 202

Query: 209 SLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQI 268
            LRT  ++S+WLNEP FV  + I        +  YFFFRE AVE     G+   SR  ++
Sbjct: 203 PLRTAQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVE--HDCGKTVFSRAARV 253

Query: 269 CRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFS 328
           C+ND+GG+  L + WTTF+KARL CS PG E   ++++LQ  F L   D    L+Y +F+
Sbjct: 254 CKNDIGGRFLLEDTWTTFMKARLNCSRPG-EVPFYYNELQSTFFLPELD----LIYGIFT 308

Query: 329 TS-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTF 387
           T+ +    SAVCV++++ + +AF GPF ++E     W      +PYP P   P    GT 
Sbjct: 309 TNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAW------LPYPNPN--PHFQCGTV 360

Query: 388 SS--TKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYD 445
                 +  +  +Q A+   LM+  V P    P F++   N  F+ +A D V   +    
Sbjct: 361 DQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFME--DNSRFSHVAVDVVQGREALVH 418

Query: 446 VLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED--SAAVTSMQISSKRHQLYVAS 503
           ++++ TD GT+ KV  VP     S+   LLEE+ +F +     + S+QI   +  L+V  
Sbjct: 419 IIYLATDYGTIKKV-RVPLNQTSSS--CLLEEIELFPERRREPIRSLQILHSQSVLFVGL 475

Query: 504 RSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGV--ACTRFQPS 546
           R  V +I L RC  + R  + C  A+DPYC WD V   CT  + S
Sbjct: 476 REHVVKIPLKRCQFY-RTRSTCIGAQDPYCGWDVVMKKCTSLEES 519


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  240 bits (612), Expect = 4e-63
 Identities = 152/427 (35%), Positives = 227/427 (53%), Gaps = 29/427 (6%)

Query: 64  RGRLFVGAENHVASLNLDNISKRA----KKLAWPAPVEWREECNWAGKDIGTECMNFVKL 119
           R  L++   + V ++NL+ + K      KKL W +  + RE C   GK    EC NF+K+
Sbjct: 66  RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124

Query: 120 LHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASV 179
               N   +  CGT AF+P C +  +        L  D   I  G  + P+D R    ++
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS------TLEYDGEEIS-GLARCPFDARQTNVAL 177

Query: 180 LVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDD 239
               +LYS   AD +  D  I+RS+G   +LRT  +DS+W+ EP F+             
Sbjct: 178 FADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY-------G 230

Query: 240 DKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGG-QRSLVNKWTTFLKARLVCSVPGV 298
           + +YFFFRE AVE    LG+   SRV +IC+ND+GG QR L   WT+FLKARL CSVPG 
Sbjct: 231 NYVYFFFREIAVEHNN-LGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG- 288

Query: 299 EGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHK 357
           +   +FD LQ +  +  + +  P +  VF+T  +   GSAVC +SM+D+ + F G F  +
Sbjct: 289 DSFFYFDVLQSITDII-QINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 EGPMHQWVSY-QGRVPYPRPGMCPSKTFG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTG 415
           + P   W +  + +VP PRPG C        + ++ DFPD+ + F ++HPLM ++V P  
Sbjct: 348 KTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA 407

Query: 416 GRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSA-EGLL 474
             P F +    Y  T I+ D  A    +Y V+F+G++ G VLKV++  K S  S  + +L
Sbjct: 408 DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSLNDSVL 465

Query: 475 LEELHVF 481
           LEE+  +
Sbjct: 466 LEEIEAY 472


>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
          Length = 652

 Score =  220 bits (561), Expect = 3e-57
 Identities = 173/568 (30%), Positives = 256/568 (45%), Gaps = 55/568 (9%)

Query: 109 IGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKS 168
           + T+C N++ LL   +   LLACGT A HP+C  +  G              + + +G +
Sbjct: 108 VRTDCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYA 156

Query: 169 PYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKV 228
           P+ P   +  +  G+E+YS +           FR +     L T       +  P+F+K 
Sbjct: 157 PFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKA 213

Query: 229 FWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSL-VNKWTTFL 287
             I   +   DDKIY+FFRE   +  P    L+VSRV Q+CR D GG+ SL V+KW TFL
Sbjct: 214 T-IVHQDQAYDDKIYYFFREDNPDKNPE-APLNVSRVAQLCRGDQGGESSLSVSKWNTFL 271

Query: 288 KARLVCSVPGVEGDTHFDQLQDVFLLS--SRDHRTPLLYAVFSTSSIFQGSAVCVYSMND 345
           KA LVCS      + +F++LQDVFLL   S   R   +Y VFS    +  SAVCVYS+ D
Sbjct: 272 KAMLVCSDAAT--NKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP--WNYSAVCVYSLGD 327

Query: 346 VRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHP 405
           + + F                Y   +P PRPG C           +  P +  Q A  HP
Sbjct: 328 IDKVFR---------TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHP 371

Query: 406 LMYNSVLPTGG--RPLFLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISV 462
            +   V P G    PLF    + Y + ++A  R+ A+ G  + VL++ TD GT+ KV+  
Sbjct: 372 EVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE- 427

Query: 463 PKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVC 522
             G +  +    + E+  F  +AA+ +M + ++R +LYV+S+  V+Q+ L  C  +G  C
Sbjct: 428 -PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGC 486

Query: 523 TECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGV 582
             C ++RDPYC WD   C     S   R   Q +   +P   C       A L+ KV   
Sbjct: 487 HGCLMSRDPYCGWDQGRCISIYSS--ERSVLQSINPAEPHKECPNPKPDKAPLQ-KVSLA 543

Query: 583 EGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYL 642
             S  +L C   S  A   W  +      + +   E   +     L +  L  +  G Y 
Sbjct: 544 PNSRYYLSCPMESRHATYSWRHKE-----NVEQSCEPGHQSPNCILFIENLTAQQYGHYF 598

Query: 643 CAAVEQGFTQPLRRLSLHVLSATQAERL 670
           C A E  + +  +   L       AE L
Sbjct: 599 CEAQEGSYFREAQHWQLLPEDGIMAEHL 626


>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
          Length = 666

 Score =  218 bits (555), Expect = 2e-56
 Identities = 172/565 (30%), Positives = 254/565 (44%), Gaps = 55/565 (9%)

Query: 112 ECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYD 171
           +C N++ LL   +   LLACGT A HP+C  +  G              + + +G +P+ 
Sbjct: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYAPFS 173

Query: 172 PRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI 231
           P   +  +  G+E+YS +           FR +     L T       +  P+F+K   I
Sbjct: 174 PDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKAT-I 229

Query: 232 PESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSL-VNKWTTFLKAR 290
              +   DDKIY+FFRE   +  P    L+VSRV Q+CR D GG+ SL V+KW TFLKA 
Sbjct: 230 VHQDQAYDDKIYYFFREDNPDKNPE-APLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAM 288

Query: 291 LVCSVPGVEGDTHFDQLQDVFLLS--SRDHRTPLLYAVFSTSSIFQGSAVCVYSMNDVRR 348
           LVCS      + +F++LQDVFLL   S   R   +Y VFS    +  SAVCVYS+ D+ +
Sbjct: 289 LVCSDAAT--NKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP--WNYSAVCVYSLGDIDK 344

Query: 349 AFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMY 408
            F                Y   +P PRPG C           +  P +  Q A  HP + 
Sbjct: 345 VFR---------TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHPEVA 388

Query: 409 NSVLPTGG--RPLFLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKG 465
             V P G    PLF    + Y + ++A  R+ A+ G  + VL++ TD GT+ KV+    G
Sbjct: 389 QRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE--PG 443

Query: 466 SRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
            +  +    + E+  F  +AA+ +M + ++R +LYV+S+  V+Q+ L  C  +G  C  C
Sbjct: 444 EQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGC 503

Query: 526 CLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGS 585
            ++RDPYC WD   C     S   R   Q +   +P   C       A L+ KV     S
Sbjct: 504 LMSRDPYCGWDQGRCISIYSS--ERSVLQSINPAEPHKECPNPKPDKAPLQ-KVSLAPNS 560

Query: 586 SAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAA 645
             +L C   S  A   W  +      + +   E   +     L +  L  +  G Y C A
Sbjct: 561 RYYLSCPMESRHATYSWRHKE-----NVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEA 615

Query: 646 VEQGFTQPLRRLSLHVLSATQAERL 670
            E  + +  +   L       AE L
Sbjct: 616 QEGSYFREAQHWQLLPEDGIMAEHL 640


>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
          Length = 501

 Score =  203 bits (517), Expect = 4e-52
 Identities = 157/512 (30%), Positives = 231/512 (45%), Gaps = 44/512 (8%)

Query: 165 KGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPK 224
           +G +P+ P   +  +  G+E+YS +           FR +     L T       +  P+
Sbjct: 2   RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQ 58

Query: 225 FVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSL-VNKW 283
           F+K   I   +   DDKIY+FFRE   +  P    L+VSRV Q+CR D GG+ SL V+KW
Sbjct: 59  FIKAT-IVHQDQAYDDKIYYFFREDNPDKNPE-APLNVSRVAQLCRGDQGGESSLSVSKW 116

Query: 284 TTFLKARLVCSVPGVEGDTHFDQLQDVFLLS--SRDHRTPLLYAVFSTSSIFQGSAVCVY 341
            TFLKA LVCS      + +F++LQDVFLL   S   R   +Y VFS    +  SAVCVY
Sbjct: 117 NTFLKAMLVCSDAAT--NKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP--WNYSAVCVY 172

Query: 342 SMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFA 401
           S+ D+ + F                Y   +P PRPG C           +  P +  Q A
Sbjct: 173 SLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVA 216

Query: 402 RNHPLMYNSVLPTGG--RPLFLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLK 458
             HP +   V P G    PLF    + Y + ++A  R+ A+ G  + VL++ TD GT+ K
Sbjct: 217 DRHPEVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHK 273

Query: 459 VISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAH 518
           V+    G +  +    + E+  F  +AA+ +M + ++R +LYV+S+  V+Q+ L  C  +
Sbjct: 274 VVE--PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVY 331

Query: 519 GRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHK 578
           G  C  C ++RDPYC WD   C     S   R   Q +   +P   C       A L+ K
Sbjct: 332 GGGCHGCLMSRDPYCGWDQGRCISIYSS--ERSVLQSINPAEPHKECPNPKPDKAPLQ-K 388

Query: 579 VFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDS 638
           V     S  +L C   S  A   W  +      + +   E   +     L +  L  +  
Sbjct: 389 VSLAPNSRYYLSCPMESRHATYSWRHKE-----NVEQSCEPGHQSPNCILFIENLTAQQY 443

Query: 639 GVYLCAAVEQGFTQPLRRLSLHVLSATQAERL 670
           G Y C A E  + +  +   L       AE L
Sbjct: 444 GHYFCEAQEGSYFREAQHWQLLPEDGIMAEHL 475


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,554,616
Number of Sequences: 37866
Number of extensions: 1544763
Number of successful extensions: 4507
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 4088
Number of HSP's gapped (non-prelim): 194
length of query: 748
length of database: 18,247,518
effective HSP length: 110
effective length of query: 638
effective length of database: 14,082,258
effective search space: 8984480604
effective search space used: 8984480604
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.