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Search of human proteins with 5454096
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5454096 serine/threonine kinase 4 [Homo sapiens]
(487 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 977 0.0
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 760 0.0
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 310 2e-84
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 310 2e-84
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 306 3e-83
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 305 6e-83
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 273 3e-73
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 273 3e-73
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 273 3e-73
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 273 3e-73
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 273 3e-73
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 273 3e-73
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 273 3e-73
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 273 3e-73
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 269 4e-72
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 269 4e-72
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 269 4e-72
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 268 8e-72
gi|145275208 myosin IIIA [Homo sapiens] 267 2e-71
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 265 7e-71
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 264 1e-70
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 264 1e-70
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 264 1e-70
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 264 1e-70
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 260 2e-69
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 253 2e-67
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 252 5e-67
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 252 5e-67
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 250 2e-66
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 250 2e-66
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 977 bits (2525), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60
Query: 61 VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
Sbjct: 61 VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 181 RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP 240
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
Sbjct: 181 RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP 240
Query: 241 PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV 300
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
Sbjct: 241 PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV 300
Query: 301 KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT 360
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
Sbjct: 301 KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT 360
Query: 361 LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK 420
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
Sbjct: 361 LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK 420
Query: 421 NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 480
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
Sbjct: 421 NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 480
Query: 481 KRRQQNF 487
KRRQQNF
Sbjct: 481 KRRQQNF 487
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 760 bits (1962), Expect = 0.0
Identities = 380/486 (78%), Positives = 435/486 (89%), Gaps = 9/486 (1%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P+ +LKKL EDSLTKQPEEVFDVLEKLGEGSYGSV+KAIHKE+GQ+VAIKQVPVESDLQE
Sbjct: 7 PKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE 66
Query: 70 IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATI 129
IIKEISIMQQCDSP+VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL EDEIATI
Sbjct: 67 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATI 126
Query: 130 LQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF 189
L+STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF
Sbjct: 127 LKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF 186
Query: 190 WMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 249
WMAPEVIQEIGYNCVADIWSLGIT+IEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL
Sbjct: 187 WMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 246
Query: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ 309
WSD+FTDFVK+CLVK+PEQRATATQLLQHPF+++AK VSILRDLI EAM++K KR E QQ
Sbjct: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQ 306
Query: 310 REVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT-LPSQLGTM 368
RE+ +++EENS+EDE+DS TMV+ + +GT+R STM++GA TMIEH+ T L S LGTM
Sbjct: 307 REL-EEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTM 365
Query: 369 VINAEDEEEE-GTMKRRDETMQPAKPSFLEYFEQ---KEKENQINSFGKSVPGPLKNS-- 422
VIN+EDEEEE GTMKR + Q +PSF++YF++ K K ++ + P P+ +
Sbjct: 366 VINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVF 425
Query: 423 -SDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKK 481
+WK+PQDGD++FLK+ ++E+LQ RL ALDPMME+EIEE+RQ+Y +KRQPILDA++AKK
Sbjct: 426 PDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKK 485
Query: 482 RRQQNF 487
RRQQNF
Sbjct: 486 RRQQNF 491
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 310 bits (794), Expect = 2e-84
Identities = 158/308 (51%), Positives = 215/308 (69%), Gaps = 13/308 (4%)
Query: 21 SLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIM 77
+L PEE+F LEK+G+GS+G V+K I T ++VAIK + +E ++++I +EI+++
Sbjct: 15 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL 74
Query: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
QCDSP+V KYYGSY K+T LWI+MEY G GS D+ L L E +IATIL+ LKGL
Sbjct: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGL 132
Query: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 197
+YLH +KIHRDIKA N+LL+ G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI+
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 192
Query: 198 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDF 257
+ Y+ ADIWSLGITAIE+A G+PP++++HPM+ +F+IP N PPT +S +F
Sbjct: 193 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEF 250
Query: 258 VKQCLVKSPEQRATATQLLQHPFV-RSAKGVSILRDLINEAMDVKLKRQESQQREVDQDD 316
V+ CL K P R TA +LL+H F+ R+AK S L +LI+ + KR +++Q D
Sbjct: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID-----RYKRWKAEQSHDDSSS 305
Query: 317 EENSEEDE 324
E++ E +
Sbjct: 306 EDSDAETD 313
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 310 bits (794), Expect = 2e-84
Identities = 158/308 (51%), Positives = 215/308 (69%), Gaps = 13/308 (4%)
Query: 21 SLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIM 77
+L PEE+F LEK+G+GS+G V+K I T ++VAIK + +E ++++I +EI+++
Sbjct: 27 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL 86
Query: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
QCDSP+V KYYGSY K+T LWI+MEY G GS D+ L L E +IATIL+ LKGL
Sbjct: 87 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGL 144
Query: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 197
+YLH +KIHRDIKA N+LL+ G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI+
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 204
Query: 198 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDF 257
+ Y+ ADIWSLGITAIE+A G+PP++++HPM+ +F+IP N PPT +S +F
Sbjct: 205 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEF 262
Query: 258 VKQCLVKSPEQRATATQLLQHPFV-RSAKGVSILRDLINEAMDVKLKRQESQQREVDQDD 316
V+ CL K P R TA +LL+H F+ R+AK S L +LI+ + KR +++Q D
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID-----RYKRWKAEQSHDDSSS 317
Query: 317 EENSEEDE 324
E++ E +
Sbjct: 318 EDSDAETD 325
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 306 bits (784), Expect = 3e-83
Identities = 156/307 (50%), Positives = 213/307 (69%), Gaps = 13/307 (4%)
Query: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIMQQCDS 82
PEE+F L+++G+GS+G VYK I T ++VAIK + +E ++++I +EI+++ QCDS
Sbjct: 16 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 75
Query: 83 PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142
P++ +Y+GSY K+T LWI+MEY G GS D+ L+ L E IATIL+ LKGL+YLH
Sbjct: 76 PYITRYFGSYLKSTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLDYLHS 133
Query: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 202
RKIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI++ Y+
Sbjct: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 193
Query: 203 CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262
ADIWSLGITAIE+A+G+PP +D+HPMR +F+IP N PPT S F +FV+ CL
Sbjct: 194 FKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACL 251
Query: 263 VKSPEQRATATQLLQHPFV-RSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSE 321
K P R TA +LL+H F+ R K S L +LI+ + KR +S+ + E++
Sbjct: 252 NKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSEGHGEESSSEDSDI 306
Query: 322 EDEMDSG 328
+ E + G
Sbjct: 307 DGEAEDG 313
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 305 bits (781), Expect = 6e-83
Identities = 155/302 (51%), Positives = 213/302 (70%), Gaps = 13/302 (4%)
Query: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIMQQCDS 82
PEE+F LE++G+GS+G V+K I T Q+VAIK + +E ++++I +EI+++ QCDS
Sbjct: 20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 79
Query: 83 PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142
+V KYYGSY K + LWI+MEY G GS D+ LR E +IAT+L+ LKGL+YLH
Sbjct: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHS 137
Query: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 202
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y+
Sbjct: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 197
Query: 203 CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262
ADIWSLGITAIE+A+G+PP +D+HPMR +F+IP N PPT ++ +F +F+ CL
Sbjct: 198 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACL 255
Query: 263 VKSPEQRATATQLLQHPF-VRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSE 321
K P R TA +LL+H F V+++K S L +LI+ + KR +++ D+ D E S+
Sbjct: 256 NKDPSFRPTAKELLKHKFIVKNSKKTSYLTELID-----RFKRWKAEGHSDDESDSEGSD 310
Query: 322 ED 323
+
Sbjct: 311 SE 312
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 273 bits (698), Expect = 3e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
Query: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 269 bits (688), Expect = 4e-72
Identities = 160/419 (38%), Positives = 240/419 (57%), Gaps = 27/419 (6%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P + L +D SL + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIK-EISIMQQCDSP-HVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK EI+++++ ++ YYG++ K + LW+VME+CGAGS++D+++ + T
Sbjct: 65 EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WS GITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NPPP K + WS F F++ CLVK+ QR + QLL+HPF+R +R +
Sbjct: 245 IPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVD----QDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
+ +D + KR E + E + +++EE E E + ++V G+ T+R
Sbjct: 304 DHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE--STLRRDFLRLQQ 361
Query: 351 ANTMIEHDDTLPSQ--LGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQ 407
N E + L Q L + ++E + + R + ++ K EQ+ +E +
Sbjct: 362 ENK--ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE 418
Score = 33.1 bits (74), Expect = 0.58
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 295 NEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTM-VRAVGDEMGTVRVASTMTDGANT 353
++ D +ES + + DD E DE SG RA ++ +++ T+ T
Sbjct: 732 HKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA----SSLNLSNGETESVKT 787
Query: 354 MIEHDDT------LPSQLGTMVINAEDEEEEGTMKRRDET 387
MI HDD PS+ GT+++ K + +
Sbjct: 788 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 827
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 269 bits (688), Expect = 4e-72
Identities = 160/419 (38%), Positives = 240/419 (57%), Gaps = 27/419 (6%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P + L +D SL + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIK-EISIMQQCDSP-HVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK EI+++++ ++ YYG++ K + LW+VME+CGAGS++D+++ + T
Sbjct: 65 EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WS GITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NPPP K + WS F F++ CLVK+ QR + QLL+HPF+R +R +
Sbjct: 245 IPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVD----QDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
+ +D + KR E + E + +++EE E E + ++V G+ T+R
Sbjct: 304 DHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE--STLRRDFLRLQQ 361
Query: 351 ANTMIEHDDTLPSQ--LGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQ 407
N E + L Q L + ++E + + R + ++ K EQ+ +E +
Sbjct: 362 ENK--ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE 418
Score = 33.1 bits (74), Expect = 0.58
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 295 NEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTM-VRAVGDEMGTVRVASTMTDGANT 353
++ D +ES + + DD E DE SG RA ++ +++ T+ T
Sbjct: 678 HKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA----SSLNLSNGETESVKT 733
Query: 354 MIEHDDT------LPSQLGTMVINAEDEEEEGTMKRRDET 387
MI HDD PS+ GT+++ K + +
Sbjct: 734 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 773
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 269 bits (688), Expect = 4e-72
Identities = 160/419 (38%), Positives = 240/419 (57%), Gaps = 27/419 (6%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P + L +D SL + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIK-EISIMQQCDSP-HVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK EI+++++ ++ YYG++ K + LW+VME+CGAGS++D+++ + T
Sbjct: 65 EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +D+WS GITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
IP NPPP K + WS F F++ CLVK+ QR + QLL+HPF+R +R +
Sbjct: 245 IPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLK 303
Query: 296 EAMD-VKLKRQESQQREVD----QDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
+ +D + KR E + E + +++EE E E + ++V G+ T+R
Sbjct: 304 DHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE--STLRRDFLRLQQ 361
Query: 351 ANTMIEHDDTLPSQ--LGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQ 407
N E + L Q L + ++E + + R + ++ K EQ+ +E +
Sbjct: 362 ENK--ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE 418
Score = 33.1 bits (74), Expect = 0.58
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 295 NEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTM-VRAVGDEMGTVRVASTMTDGANT 353
++ D +ES + + DD E DE SG RA ++ +++ T+ T
Sbjct: 840 HKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA----SSLNLSNGETESVKT 895
Query: 354 MIEHDDT------LPSQLGTMVINAEDEEEEGTMKRRDET 387
MI HDD PS+ GT+++ K + +
Sbjct: 896 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 935
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 268 bits (685), Expect = 8e-72
Identities = 138/306 (45%), Positives = 197/306 (64%), Gaps = 12/306 (3%)
Query: 20 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIM 77
D + P+E F++++++G G+YG VYKA + TG++ AIK + +E D + +EI +M
Sbjct: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
Query: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
+ C P++V Y+GSY + LWI ME+CG GS+ DI + L+E +IA + + TL+GL
Sbjct: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQGL 124
Query: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 196
YLH K+HRDIK NILL GH KLADFGV+ Q+T T+AKR + IGTP+WMAPEV
Sbjct: 125 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAA 184
Query: 197 --QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 252
++ GYN + D+W++GITAIE+AE +PP D+HPMRA+F++ + PP + WS+
Sbjct: 185 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
Query: 253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV 312
+F FVK L K+P++R TA +LLQHPFV + R L E +D S +
Sbjct: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ----HLTRSLAIELLDKVNNPDHSTYHDF 300
Query: 313 DQDDEE 318
D DD E
Sbjct: 301 DDDDPE 306
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 267 bits (682), Expect = 2e-71
Identities = 134/280 (47%), Positives = 187/280 (66%), Gaps = 15/280 (5%)
Query: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEIIKEISIMQQC-DSP 83
P + +++ E +G+G+YG V+K ++K+ GQ A+K + P+ +EI E +I++ D P
Sbjct: 17 PSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDHP 76
Query: 84 HVVKYYGSYFK----NTD-LWIVMEYCGAGSVSDIIR---LRNKTLTEDEIATILQSTLK 135
+VV++YG YFK N D LW+V+E C GSV+D+++ R + ++E IA IL L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 136 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 195
GL++LH + IHRD+K NILL TEG KL DFGV+ QLT T +RNT +GTPFWMAPEV
Sbjct: 137 GLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEV 196
Query: 196 IQ-----EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELW 250
I + Y+ D WSLGITAIE+ +G PP AD+HPMRA+F IP NPPP R+PELW
Sbjct: 197 IACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELW 256
Query: 251 SDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSIL 290
S F DF+ +CL K E+R T ++LLQH F+ +G ++
Sbjct: 257 SAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVM 296
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 265 bits (677), Expect = 7e-71
Identities = 150/419 (35%), Positives = 232/419 (55%), Gaps = 29/419 (6%)
Query: 11 RRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD--LQ 68
+R+ ++ + P EV++++ +LG+G++G VYKA +KETG + A K + +S+ L+
Sbjct: 17 KRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE 76
Query: 69 EIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIAT 128
+ I EI I+ CD P++VK G+Y+ + LWI++E+C G+V I+ ++ LTE +I
Sbjct: 77 DYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQV 136
Query: 129 ILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTP 188
+ + L+ L +LH R IHRD+KAGN+L+ EG +LADFGV+ + T+ KR++ IGTP
Sbjct: 137 VCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTP 196
Query: 189 FWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPT 243
+WMAPEV+ ++ Y+ ADIWSLGIT IEMA+ +PP+ +++PMR + I + PPT
Sbjct: 197 YWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPT 256
Query: 244 FRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLK 303
P WS F DF+K L K+PE R +A QLL+HPFV S LR+L+ EA
Sbjct: 257 LLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEA------ 310
Query: 304 RQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPS 363
+ E++ +E EED +D+ + + V S D PS
Sbjct: 311 -KAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPS 369
Query: 364 QLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNS 422
Q + + E + D ++Q P + N G +VP PL+ S
Sbjct: 370 Q------SQDSVNEPCSQPSGDRSLQTTSPPVVA---------PGNENGLAVPVPLRKS 413
Score = 32.3 bits (72), Expect = 1.00
Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 8/119 (6%)
Query: 370 INAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEK-ENQINSFGKSVPGPLKNSSDWKIP 428
IN E K + + Q K E +Q++K ENQ+ N S+ +
Sbjct: 827 INGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES---NMSELQQL 883
Query: 429 QDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF 487
Q+ L VE ++L ALD Q ++E R K + +++ + + + KKR Q+ F
Sbjct: 884 QNEKCHLL----VEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMF 938
Score = 31.6 bits (70), Expect = 1.7
Identities = 21/105 (20%), Positives = 43/105 (40%), Gaps = 8/105 (7%)
Query: 304 RQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPS 363
+Q SQQ E Q E ++ + ++ E + + + ++EH+
Sbjct: 841 KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHE----- 895
Query: 364 QLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
T + A DE +K + ++P K + E QK++E ++
Sbjct: 896 ---TQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEM 937
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 264 bits (675), Expect = 1e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
Query: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 264 bits (675), Expect = 1e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
Query: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 264 bits (675), Expect = 1e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
Query: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 264 bits (675), Expect = 1e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
Query: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
Query: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 260 bits (664), Expect = 2e-69
Identities = 144/397 (36%), Positives = 234/397 (58%), Gaps = 27/397 (6%)
Query: 12 RQLKKLDEDSLTKQ---------PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP 62
R++ KL + KQ PE+ ++++ +LG+G++G VYKA +KET + A K +
Sbjct: 7 RKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID 66
Query: 63 VESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
+S+ L++ + EI I+ CD P++VK +++ +LWI++E+C G+V ++ +
Sbjct: 67 TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP 126
Query: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
LTE +I + + TL L YLH + IHRD+KAGNIL +G KLADFGV+ + T T+ +
Sbjct: 127 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 186
Query: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
R++ IGTP+WMAPEV+ ++ Y+ AD+WSLGIT IEMAE +PP+ +++PMR +
Sbjct: 187 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLK 246
Query: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
I + PPT +P WS NF DF+K+CL K+ + R T +QLLQHPFV + +R+LI
Sbjct: 247 IAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDSNKPIRELIA 305
Query: 296 EAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMI 355
EA +++ E +D +E EE+E ++ + A + +AS+ D +
Sbjct: 306 EA--------KAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNA 357
Query: 356 EHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAK 392
+++ + T N+ED+ + + T +P K
Sbjct: 358 CILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEK 392
Score = 30.0 bits (66), Expect = 4.9
Identities = 24/118 (20%), Positives = 48/118 (40%), Gaps = 17/118 (14%)
Query: 291 RDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
RD I + + KRQ++++ Q E + ++ VR + +
Sbjct: 1102 RDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVR---------ELHQLQNEK 1152
Query: 351 ANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
+ ++EH+ T + DEE +K E ++P K + E F +K +E ++
Sbjct: 1153 CHLLVEHE--------TQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEV 1202
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 253 bits (647), Expect = 2e-67
Identities = 130/304 (42%), Positives = 193/304 (63%), Gaps = 8/304 (2%)
Query: 20 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIM 77
D + P + F++L+++G G+YG VYKA T ++ A+K V ++ D+ + +EI+I+
Sbjct: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
Query: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
++C P+VV Y GSY +N LWI ME+CG GS+ +I L E +IA + + LKGL
Sbjct: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP-LEERQIAYVCREALKGL 124
Query: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 196
+LH KIHRDIK N+LL +G KLADFGV+G+LT ++AKR + IGTP+WMAPEV
Sbjct: 125 HHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAA 184
Query: 197 --QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 252
++ GYN + D+W+LGITAIE+ E +PP +HPMRA+ ++ + PP R W+
Sbjct: 185 VERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQ 244
Query: 253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV 312
NF F+K L K+P++R TA +LLQHPF ++L L+++A D L + E+
Sbjct: 245 NFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCEL 304
Query: 313 DQDD 316
+ D
Sbjct: 305 ETYD 308
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 252 bits (644), Expect = 5e-67
Identities = 127/276 (46%), Positives = 179/276 (64%), Gaps = 15/276 (5%)
Query: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIK-EISIMQQCDS-P 83
P + ++++E +G+G+YG VYK +K G + A+K + SD+ E I+ E +I+Q + P
Sbjct: 23 PTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHP 82
Query: 84 HVVKYYGSYFK-----NTDLWIVMEYCGAGSVSDIIR--LR-NKTLTEDEIATILQSTLK 135
+VVK+YG ++K LW+V+E C GSV+++++ LR + L E I+ IL L
Sbjct: 83 NVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALL 142
Query: 136 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 195
GL++LH R IHRD+K NILL TEG KL DFGV+ QLT T +RNT +GTPFWMAPEV
Sbjct: 143 GLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV 202
Query: 196 IQ-----EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELW 250
I + Y+ D+WSLGITAIE+ +G PP D+HP++ +F IP NPPPT PE W
Sbjct: 203 IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKW 262
Query: 251 SDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG 286
+ F F+ QCL+K E+R + T LL HPF++ G
Sbjct: 263 CEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHG 298
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 252 bits (644), Expect = 5e-67
Identities = 127/276 (46%), Positives = 179/276 (64%), Gaps = 15/276 (5%)
Query: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIK-EISIMQQCDS-P 83
P + ++++E +G+G+YG VYK +K G + A+K + SD+ E I+ E +I+Q + P
Sbjct: 23 PTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHP 82
Query: 84 HVVKYYGSYFK-----NTDLWIVMEYCGAGSVSDIIR--LR-NKTLTEDEIATILQSTLK 135
+VVK+YG ++K LW+V+E C GSV+++++ LR + L E I+ IL L
Sbjct: 83 NVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALL 142
Query: 136 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 195
GL++LH R IHRD+K NILL TEG KL DFGV+ QLT T +RNT +GTPFWMAPEV
Sbjct: 143 GLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV 202
Query: 196 IQ-----EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELW 250
I + Y+ D+WSLGITAIE+ +G PP D+HP++ +F IP NPPPT PE W
Sbjct: 203 IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKW 262
Query: 251 SDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG 286
+ F F+ QCL+K E+R + T LL HPF++ G
Sbjct: 263 CEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHG 298
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 250 bits (638), Expect = 2e-66
Identities = 136/309 (44%), Positives = 201/309 (65%), Gaps = 12/309 (3%)
Query: 17 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEI 74
+D D + P + +D+L++LG G+YG V+KA K +G +VA+K V +E D+ + KEI
Sbjct: 4 VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEI 63
Query: 75 SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 134
I++ C ++V Y+GSY LWI ME+CGAGS+ DI ++ +L+E +I+ + + L
Sbjct: 64 LILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVL 122
Query: 135 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 194
+GL YLH +KIHRDIK NIL+N G +LADFG++ Q+ T+A+R + IGTP+WMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 195 VIQ---EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPEL 249
V + GYN + DIWSLGITAIE+AE +PP D+HP+R +F++ + PP ++
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
Query: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ 309
WS F +F+K L KSP++R +AT++L H V S G++ R LI + +D KLK
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV-SQPGLN--RGLILDLLD-KLKNPGKGP 298
Query: 310 REVDQDDEE 318
D +DEE
Sbjct: 299 SIGDIEDEE 307
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 250 bits (638), Expect = 2e-66
Identities = 136/309 (44%), Positives = 201/309 (65%), Gaps = 12/309 (3%)
Query: 17 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEI 74
+D D + P + +D+L++LG G+YG V+KA K +G +VA+K V +E D+ + KEI
Sbjct: 4 VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEI 63
Query: 75 SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 134
I++ C ++V Y+GSY LWI ME+CGAGS+ DI ++ +L+E +I+ + + L
Sbjct: 64 LILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVL 122
Query: 135 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 194
+GL YLH +KIHRDIK NIL+N G +LADFG++ Q+ T+A+R + IGTP+WMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 195 VIQ---EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPEL 249
V + GYN + DIWSLGITAIE+AE +PP D+HP+R +F++ + PP ++
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
Query: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ 309
WS F +F+K L KSP++R +AT++L H V S G++ R LI + +D KLK
Sbjct: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV-SQPGLN--RGLILDLLD-KLKNPGKGP 298
Query: 310 REVDQDDEE 318
D +DEE
Sbjct: 299 SIGDIEDEE 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,187,536
Number of Sequences: 37866
Number of extensions: 890930
Number of successful extensions: 7366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 764
Number of HSP's successfully gapped in prelim test: 147
Number of HSP's that attempted gapping in prelim test: 4366
Number of HSP's gapped (non-prelim): 1419
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.