Search of human proteins with 5453790

Search of human proteins with 5453790

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453790 nicotinamide N-methyltransferase [Homo sapiens]
         (264 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453790 nicotinamide N-methyltransferase [Homo sapiens]            535   e-152
gi|66933018 indolethylamine N-methyltransferase [Homo sapiens]        270   1e-72
gi|4505921 phenylethanolamine N-methyltransferase [Homo sapiens]      172   3e-43
gi|118442825 methyltransferase like 6 [Homo sapiens]                   37   0.018
gi|93141204 methyltransferase like 2B [Homo sapiens]                   33   0.26 
gi|165932358 methyltransferase like 2A [Homo sapiens]                  33   0.26 
gi|105554437 forkhead box B1 [Homo sapiens]                            30   2.8  
gi|41872631 fatty acid synthase [Homo sapiens]                         29   3.7  
gi|23510398 pantothenate kinase 1 isoform gamma [Homo sapiens]         29   3.7  
gi|236463300 hypothetical protein LOC79846 isoform 2 [Homo sapiens]    28   6.3  
gi|236463164 hypothetical protein LOC79846 isoform 1 [Homo sapiens]    28   6.3  
gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo ...    28   6.3  
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H...    28   8.2  
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              28   8.2  

>gi|5453790 nicotinamide N-methyltransferase [Homo sapiens]
          Length = 264

 Score =  535 bits (1377), Expect = e-152
 Identities = 264/264 (100%), Positives = 264/264 (100%)

Query: 1   MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI 60
           MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
Sbjct: 1   MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI 60

Query: 61  DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN 120
           DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
Sbjct: 61  DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN 120

Query: 121 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL 180
           RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
Sbjct: 121 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL 180

Query: 181 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ 240
           RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
Sbjct: 181 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ 240

Query: 241 SYSSTMANNEGLFSLVARKLSRPL 264
           SYSSTMANNEGLFSLVARKLSRPL
Sbjct: 241 SYSSTMANNEGLFSLVARKLSRPL 264


>gi|66933018 indolethylamine N-methyltransferase [Homo sapiens]
          Length = 263

 Score =  270 bits (690), Expect = 1e-72
 Identities = 140/263 (53%), Positives = 178/263 (67%)

Query: 1   MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI 60
           M+ GFT  D Y  HF PRDYL  YY F    S E+++LK  L+ L K F   G++GD LI
Sbjct: 1   MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI 60

Query: 61  DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN 120
           DIGSGPTIYQ+L+AC+SF++I ++D++D+N +ELEKWLKKEP A+DW+P V + C+LEGN
Sbjct: 61  DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN 120

Query: 121 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL 180
             +  EKEEKLR AVK+VLKCDV    PL    LP ADCVL+ L ++ AC  L  Y  AL
Sbjct: 121 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL 180

Query: 181 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ 240
            NL SLLKPGG LV    L+   YM+G+++FS + L +E VE AV +AG+ IE      Q
Sbjct: 181 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ 240

Query: 241 SYSSTMANNEGLFSLVARKLSRP 263
           SYS T A N G+  +VARK   P
Sbjct: 241 SYSVTNAANNGVCFIVARKKPGP 263


>gi|4505921 phenylethanolamine N-methyltransferase [Homo sapiens]
          Length = 282

 Score =  172 bits (436), Expect = 3e-43
 Identities = 89/193 (46%), Positives = 128/193 (66%), Gaps = 2/193 (1%)

Query: 42  LKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKE 101
           L+ L + F    V G  LIDIGSGPT+YQLLSAC  F++I +TD+ + N QEL +WL++E
Sbjct: 58  LRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEE 117

Query: 102 PEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGA-VPLP-PADC 159
           P AF+WS    + C +EG      +KE +LR  VK+VL  DV Q QPLGA  P P PAD 
Sbjct: 118 PGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADA 177

Query: 160 VLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGRE 219
           ++S  CL+A  PDL ++ RAL ++ +LL+PGG L+++ AL+ S+Y+ GE + + +P+  E
Sbjct: 178 LVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEE 237

Query: 220 AVEAAVKEAGYTI 232
            V  A+  +GY +
Sbjct: 238 EVREALVRSGYKV 250


>gi|118442825 methyltransferase like 6 [Homo sapiens]
          Length = 284

 Score = 37.0 bits (84), Expect = 0.018
 Identities = 31/123 (25%), Positives = 50/123 (40%), Gaps = 18/123 (14%)

Query: 85  DYSDQNLQELEKW----------LKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQA 134
           ++ DQ L  LE            L+++P  F       Y CD     ++  ++       
Sbjct: 75  EFEDQKLTMLEAGCGVGNCLFPLLEEDPNIF------AYACDFSPRAIEYVKQNPLYDTE 128

Query: 135 VKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLV 194
             +V +CD+T+   L  VP    D V+    L A  PD       L+N+  +LKPG  ++
Sbjct: 129 RCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPD--KMHLVLQNIYKVLKPGKSVL 186

Query: 195 IMD 197
             D
Sbjct: 187 FRD 189


>gi|93141204 methyltransferase like 2B [Homo sapiens]
          Length = 378

 Score = 33.1 bits (74), Expect = 0.26
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)

Query: 141 CDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMD 197
           CD  +S P   VP    D ++    L A  PD     +A+  L  LLKPGG +++ D
Sbjct: 241 CDEEKSYP---VPKGSLDIIILIFVLSAVVPDKMQ--KAINRLSRLLKPGGMVLLRD 292


>gi|165932358 methyltransferase like 2A [Homo sapiens]
          Length = 378

 Score = 33.1 bits (74), Expect = 0.26
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)

Query: 141 CDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMD 197
           CD  +S P   VP    D ++    L A  PD     +A+  L  LLKPGG +++ D
Sbjct: 241 CDEEKSYP---VPKGSLDIIILIFVLSAIVPDKMQ--KAINRLSRLLKPGGMMLLRD 292


>gi|105554437 forkhead box B1 [Homo sapiens]
          Length = 325

 Score = 29.6 bits (65), Expect = 2.8
 Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 4/82 (4%)

Query: 137 QVLKCD-VTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGF--- 192
           +VLK D +  S+P  A         L    L A+   LP    A  NLG + +P GF   
Sbjct: 110 KVLKSDHLAPSKPADAAQYLQQQAKLRLSALAASGTHLPQMPAAAYNLGGVAQPSGFKHP 169

Query: 193 LVIMDALKSSYYMIGEQKFSSL 214
             I + +   Y M G   FS++
Sbjct: 170 FAIENIIAREYKMPGGLAFSAM 191


>gi|41872631 fatty acid synthase [Homo sapiens]
          Length = 2511

 Score = 29.3 bits (64), Expect = 3.7
 Identities = 22/72 (30%), Positives = 33/72 (45%)

Query: 129  EKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLK 188
            + L  A  ++ + DV Q Q   A P P A      L  + A   L     AL N+ + L+
Sbjct: 1278 QALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALR 1337

Query: 189  PGGFLVIMDALK 200
             GGFL++   L+
Sbjct: 1338 EGGFLLLHTLLR 1349


>gi|23510398 pantothenate kinase 1 isoform gamma [Homo sapiens]
          Length = 314

 Score = 29.3 bits (64), Expect = 3.7
 Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 47  KIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKE 101
           K +CLD     LL+++GSG +I  + S  +++K +  T + +   +E    + KE
Sbjct: 175 KPYCLDNPYPMLLVNMGSGVSILAVYSK-DNYKRVTGTSFGNMMSKEKRDSISKE 228


>gi|236463300 hypothetical protein LOC79846 isoform 2 [Homo sapiens]
          Length = 923

 Score = 28.5 bits (62), Expect = 6.3
 Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 8/98 (8%)

Query: 1   MESGFTSKDTYLSHFNP---RDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGD 57
           +E GFT      + FN    ++ L K  K  +  S E   LK LL N+  I C D     
Sbjct: 310 IECGFTKDLILFATFNEVKSQNLLVKGLKLSN--SYEDFELKKLLFNVIVILCKDLPTVQ 367

Query: 58  LLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELE 95
           LLID   G  I  L +  +  ++  + D+S    +EL+
Sbjct: 368 LLID---GKVILALFTYVKKPEKQKIIDWSAAQHEELQ 402


>gi|236463164 hypothetical protein LOC79846 isoform 1 [Homo sapiens]
          Length = 941

 Score = 28.5 bits (62), Expect = 6.3
 Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 8/98 (8%)

Query: 1   MESGFTSKDTYLSHFNP---RDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGD 57
           +E GFT      + FN    ++ L K  K  +  S E   LK LL N+  I C D     
Sbjct: 328 IECGFTKDLILFATFNEVKSQNLLVKGLKLSN--SYEDFELKKLLFNVIVILCKDLPTVQ 385

Query: 58  LLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELE 95
           LLID   G  I  L +  +  ++  + D+S    +EL+
Sbjct: 386 LLID---GKVILALFTYVKKPEKQKIIDWSAAQHEELQ 420


>gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo
           sapiens]
          Length = 740

 Score = 28.5 bits (62), Expect = 6.3
 Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 2/81 (2%)

Query: 22  EKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEI 81
           E++   GS   AE  +     +++  I     ++G+  + +   P +YQL+      KEI
Sbjct: 414 EEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLT--KEI 471

Query: 82  VVTDYSDQNLQELEKWLKKEP 102
              D   ++    E WL+K+P
Sbjct: 472 PSPDDGFESKSLYESWLEKDP 492


>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
            sapiens]
          Length = 1512

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 15/38 (39%), Positives = 25/38 (65%)

Query: 57   DLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQEL 94
            +L I+  +G ++  LLS   +FKE VV +Y++Q L+ L
Sbjct: 1320 NLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGL 1357


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)

Query: 98  LKKEPEAFDWSPVVTYVCDLEGNRVKG-PEKEEKLRQAV 135
           LKK+    D+ P++TY      N ++G  E+EE+L +A+
Sbjct: 62  LKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAI 100


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,421,217
Number of Sequences: 37866
Number of extensions: 460990
Number of successful extensions: 1242
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1236
Number of HSP's gapped (non-prelim): 14
length of query: 264
length of database: 18,247,518
effective HSP length: 100
effective length of query: 164
effective length of database: 14,460,918
effective search space: 2371590552
effective search space used: 2371590552
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.