Search of human proteins with 53832005

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|53832005 calcium channel, voltage-dependent, R type, alpha
1E subunit [Homo sapiens]
         (2270 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...  4540   0.0  
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s...  2409   0.0  
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s...  2347   0.0  
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ...  2283   0.0  
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1...   751   0.0  
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1...   751   0.0  
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1...   749   0.0  
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1...   748   0.0  
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1...   748   0.0  
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1...   748   0.0  
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1...   747   0.0  
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1...   746   0.0  
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1...   745   0.0  
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1...   744   0.0  
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1...   744   0.0  
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1...   744   0.0  
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1...   743   0.0  
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1...   743   0.0  
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1...   741   0.0  
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1...   740   0.0  
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1...   738   0.0  
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F...   736   0.0  
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1...   734   0.0  
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1...   733   0.0  
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1...   733   0.0  
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1...   733   0.0  
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1...   729   0.0  
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1...   727   0.0  
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ...   727   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...   326   1e-88

>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
            subunit [Homo sapiens]
          Length = 2270

 Score = 4540 bits (11776), Expect = 0.0
 Identities = 2270/2270 (100%), Positives = 2270/2270 (100%)

Query: 1    MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQ 60
            MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQ
Sbjct: 1    MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQ 60

Query: 61   NCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPM 120
            NCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPM
Sbjct: 61   NCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPM 120

Query: 121  SRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHF 180
            SRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHF
Sbjct: 121  SRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHF 180

Query: 181  NTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 240
            NTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL
Sbjct: 181  NTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 240

Query: 241  EFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVL 300
            EFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVL
Sbjct: 241  EFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVL 300

Query: 301  TVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
            TVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER
Sbjct: 301  TVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360

Query: 361  VENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRT 420
            VENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRT
Sbjct: 361  VENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRT 420

Query: 421  EAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYW 480
            EAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYW
Sbjct: 421  EAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYW 480

Query: 481  IVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSF 540
            IVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSF
Sbjct: 481  IVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSF 540

Query: 541  NCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM 600
            NCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM
Sbjct: 541  NCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM 600

Query: 601  KSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWN 660
            KSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWN
Sbjct: 601  KSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWN 660

Query: 661  EVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 720
            EVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE
Sbjct: 661  EVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 720

Query: 721  EAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQ 780
            EAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQ
Sbjct: 721  EAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQ 780

Query: 781  RTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGL 840
            RTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGL
Sbjct: 781  RTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGL 840

Query: 841  ALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAG 900
            ALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAG
Sbjct: 841  ALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAG 900

Query: 901  GGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDH 960
            GGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDH
Sbjct: 901  GGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDH 960

Query: 961  ELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVV 1020
            ELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVV
Sbjct: 961  ELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVV 1020

Query: 1021 LTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPL 1080
            LTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPL
Sbjct: 1021 LTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPL 1080

Query: 1081 VDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTN 1140
            VDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTN
Sbjct: 1081 VDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTN 1140

Query: 1141 PIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFE 1200
            PIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFE
Sbjct: 1141 PIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFE 1200

Query: 1201 MVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVL 1260
            MVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVL
Sbjct: 1201 MVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVL 1260

Query: 1261 RVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTD 1320
            RVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTD
Sbjct: 1261 RVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTD 1320

Query: 1321 SSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQH 1380
            SSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQH
Sbjct: 1321 SSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQH 1380

Query: 1381 SVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLE 1440
            SVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLE
Sbjct: 1381 SVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLE 1440

Query: 1441 KNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYY 1500
            KNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYY
Sbjct: 1441 KNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYY 1500

Query: 1501 SAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILT 1560
            SAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILT
Sbjct: 1501 SAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILT 1560

Query: 1561 DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1620
            DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI
Sbjct: 1561 DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1620

Query: 1621 YAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP 1680
            YAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP
Sbjct: 1621 YAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP 1680

Query: 1681 DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740
            DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH
Sbjct: 1681 DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740

Query: 1741 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED 1800
            LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED
Sbjct: 1741 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED 1800

Query: 1801 MTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKA 1860
            MTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKA
Sbjct: 1801 MTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKA 1860

Query: 1861 SDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPY 1920
            SDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPY
Sbjct: 1861 SDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPY 1920

Query: 1921 LQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLVVTDPSSMRRSFST 1980
            LQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLVVTDPSSMRRSFST
Sbjct: 1921 LQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLVVTDPSSMRRSFST 1980

Query: 1981 IRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRER 2040
            IRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRER
Sbjct: 1981 IRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRER 2040

Query: 2041 GRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSI 2100
            GRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSI
Sbjct: 2041 GRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSI 2100

Query: 2101 PSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESN 2160
            PSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESN
Sbjct: 2101 PSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESN 2160

Query: 2161 NACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRS 2220
            NACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRS
Sbjct: 2161 NACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRS 2220

Query: 2221 NTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC 2270
            NTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC
Sbjct: 2221 NTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC 2270


>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
            sapiens]
          Length = 2506

 Score = 2409 bits (6243), Expect = 0.0
 Identities = 1369/2363 (57%), Positives = 1607/2363 (68%), Gaps = 242/2363 (10%)

Query: 1    MARFGEAVVARPGSGD------------GDSDQSRNRQGTPVPASGQAAAYKQTKAQRAR 48
            MARFG+ + AR G G             G      +RQG      G    YKQ+ AQRAR
Sbjct: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQ---PGAQRMYKQSMAQRAR 57

Query: 49   TMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLAL 108
            TMALYNPIPVRQNC TVNRSLF+F EDN+VRKYAKK+ +WPPFEYMILATIIANCIVLAL
Sbjct: 58   TMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLAL 117

Query: 109  EQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV 168
            EQHLP+DDKTPMS RL+ TEPYFIGIFCFEAGIKI+ALGF FHKGSYLRNGWNVMDF+VV
Sbjct: 118  EQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVV 177

Query: 169  LSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLL 228
            L+GILAT GT F    DLRTLRAVRVLRPLKLVSGIPSLQ+VLKSIMKAM+PLLQIGLLL
Sbjct: 178  LTGILATVGTEF----DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLL 233

Query: 229  FFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGYECKD-WI 283
            FFAIL+FAIIGLEFY GK H  CF   +  ++G + P PCG +     CP G +C+  W 
Sbjct: 234  FFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG-ESPAPCGTEEPARTCPNGTKCQPYWE 292

Query: 284  GPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVL 343
            GPN+GITQFDNILFAVLTVFQCITMEGWT +LYN+NDA G TWNWLYFIPLIIIGSFF+L
Sbjct: 293  GPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFML 352

Query: 344  NLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAE-ENKNA 402
            NLVLGVLSGEFAKERERVENRRAF+KLRRQQQIERELNGY  WI KAEEV+LAE E    
Sbjct: 353  NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412

Query: 403  GTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKE 462
                 + LRR TIK+S+T+ +  + +++   DI+SVG+P ARASIKSAK++  ++F  KE
Sbjct: 413  QRHPFDALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKE 472

Query: 463  RLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLE 522
            R +R  IR MVK+Q FYW VLSLVALNT CVAIVH+NQP+WL+  LYYAEF+FLGLF+ E
Sbjct: 473  RRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSE 532

Query: 523  MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
            M +KMYG+G R YFHSSFNCFD GV +GSIFEV+WA+ +PGTSFGISVLRALRLLRIFK+
Sbjct: 533  MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 592

Query: 583  TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDT 642
            TKYWASLRNLVVSL++SMKSIISLLFLLFLFIVVFALLGMQLFGG+FNF++GTP  NFDT
Sbjct: 593  TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDT 652

Query: 643  FPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIA 702
            FPAAIMTVFQILTGEDWNEVMY+GI+SQGGV  GM  +IYFIVLTLFGNYTLLNVFLAIA
Sbjct: 653  FPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIA 712

Query: 703  VDNLANAQELTKDEQEEEEAFNQKHALQKAKEV---SPMSAPNMPSI--ERDRRRRHHMS 757
            VDNLANAQELTKDEQEEEEA NQK ALQKAKEV   SP+SA NM     E+ + ++   S
Sbjct: 713  VDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKS 772

Query: 758  MWEPRSSHLRERRRR-------HHMSVWEQRTSQLRKHMQMSSQEALNREEA--PTMNPL 808
            +WE R+S +R++          + M   E+  +   +H++   +  L+R     P  N  
Sbjct: 773  VWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRN 832

Query: 809  NPLNPLSSLNP--------------LNAHPSLYRRPRAIEGLALGLALEK----FEEERI 850
            N  N   +  P              L      + R R   G A GL   +     +E  +
Sbjct: 833  NNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSA-GLDARRPWAGSQEAEL 891

Query: 851  SRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFED 910
            SR G    +    +     ++     G+ E      P   +     ++ G  E+      
Sbjct: 892  SREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRH---VHRQGGSRESRSGSPR 948

Query: 911  RARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKD------HELRG 964
                 + +R   HRR   EG E  +  R+R     R    A   EGE +         R 
Sbjct: 949  TGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRP---ARGGEGEGEGPDGGERRRRH 1005

Query: 965  NHGAKEPTIQEERAQDL-RRTNSLMVSRGSG-------------LAGGLDEADTPLVLPH 1010
             HGA      + R +D  RR      ++GSG             +   L   D PL    
Sbjct: 1006 RHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDI 1065

Query: 1011 PELEVGKHVVLTEQEPEGS-------SEQALLGNVQLDMGRVIS---------------- 1047
              ++  K        P GS          A +GN   D G +++                
Sbjct: 1066 DNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGN-STDPGPMLAIPAMATNPQNAASRRT 1124

Query: 1048 ------------QSEPDLSCITANTDKATTESTSV-------TVAIPDV-DPLVDSTVVH 1087
                           P+ S I  N     T S          TV IP    P ++ TVV 
Sbjct: 1125 PNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQ 1184

Query: 1088 ISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETG-KAMVPHSSMFIFSTTNPIRRAC 1146
            ++   + +  P KE E +E+EE+        ++ E G K M P+SSMFI STTNP+RR C
Sbjct: 1185 VNKNANPDPLPKKEEEKKEEEED--------DRGEDGPKPMPPYSSMFILSTTNPLRRLC 1236

Query: 1147 HYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMI 1206
            HYI+NLRYFEMCIL+VIA SSIALAAEDPV  N+ RN VLRYFDYVFTGVFTFEMVIKMI
Sbjct: 1237 HYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMI 1296

Query: 1207 DQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPL 1266
            D GL+L  G+YFRDLWNILDF+VV GALVAFA     G +KG+DI TIKSLRVLRVLRPL
Sbjct: 1297 DLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFT---GNSKGKDINTIKSLRVLRVLRPL 1353

Query: 1267 KTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTE 1326
            KTIKRLPKLKAVFDCVV SLKNVFNILIVY LFMFIFAV+AVQLFKGKFF+CTD SK+ E
Sbjct: 1354 KTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFE 1413

Query: 1327 KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTE 1386
            K+C G Y+ +EKN+++ + REWK++EFHYDN++WALLTLFTVSTGEGWPQVL+HSVD T 
Sbjct: 1414 KDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1473

Query: 1387 EDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERAC 1446
            E++GPS   RMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEE SLEKNERAC
Sbjct: 1474 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERAC 1533

Query: 1447 IDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTY 1506
            IDFAISAKPLTR+MPQN+ +FQYR+W FVVSP FEYTIMAMIALNT+VLMMK+Y A   Y
Sbjct: 1534 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAY 1593

Query: 1507 ELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVN 1566
            E AL+  NI FT +FSLECVLKV+AFG LNYFRD WNIFDF+TV+GSIT+I++T+     
Sbjct: 1594 ENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE---FG 1650

Query: 1567 TSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1626
             +  N+SFL+LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM
Sbjct: 1651 NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1710

Query: 1627 QVFGNIKLD--------EESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
            QVFGNI +D        +E  I  HNNFR+FF +LMLLFRSATGEAW  IMLSCL  K C
Sbjct: 1711 QVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC 1770

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGP 1738
            + +    SG    E CG + AY YFVSFIF CSFLMLNLFVAVIMDNFEYLTRDSSILGP
Sbjct: 1771 DKN----SGILTRE-CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGP 1825

Query: 1739 HHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVA 1798
            HHLDE+VRVWAEYD AA GR+ Y +MY+ML  MSPPLGLGK+CP++VAYKRL+ M++PVA
Sbjct: 1826 HHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVA 1885

Query: 1799 EDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMP 1858
            +D TVHF STLMALIRTALDIKIAKGGAD+QQ+D+EL+KE +AIWP+LSQK LDLLV   
Sbjct: 1886 DDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPH 1945

Query: 1859 KASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAP-MFQRMEPSSLPQEIIANAKA 1917
            K++DLTVGKIYAAMMIM+YY+QSK KK +   EEQ   P MFQRMEP S  QE      A
Sbjct: 1946 KSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNA 2005

Query: 1918 LPYLQQDPVSGL----SGRSGYPSMSPLSPQDIFQ------------------------L 1949
            LP  Q DP   L    SG    PS      Q++FQ                        +
Sbjct: 2006 LPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSV 2065

Query: 1950 ACMDPADDG----------QFQERQSLVVTDPSSMRR--------SFSTIRD----KRSN 1987
               +   DG          + Q R + +   P+  +R        + STI D    KRS 
Sbjct: 2066 EMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSA 2125

Query: 1988 S------SWLEEFSMER-----SSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSD---TH 2033
            S        L+++S+ER     +  +  + R RS+ +S R      + D+G  +D   T 
Sbjct: 2126 SVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTT 2185

Query: 2034 RSG-------GRERGRSKERKHLL------------SPDVSRCNSEERGTQADWESPERR 2074
            +SG        +ERGR K+RKH               PD  R  ++ER       + ++R
Sbjct: 2186 QSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDR-YAQERPDHGRARARDQR 2244

Query: 2075 QSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIR 2134
             SRSPSEGR    +RQG+ S+S S  PS S TSTPRR RRQLP  P  PRP +SYS +IR
Sbjct: 2245 WSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIR 2304

Query: 2135 HAGSISPPADGSEEGSPLTSQAL 2157
             AG   PP    ++      QA+
Sbjct: 2305 KAGGSGPPQQQQQQQQQQQQQAV 2327


>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
            sapiens]
          Length = 2261

 Score = 2347 bits (6083), Expect = 0.0
 Identities = 1335/2297 (58%), Positives = 1567/2297 (68%), Gaps = 243/2297 (10%)

Query: 1    MARFGEAVVARPGSGD------------GDSDQSRNRQGTPVPASGQAAAYKQTKAQRAR 48
            MARFG+ + AR G G             G      +RQG      G    YKQ+ AQRAR
Sbjct: 1    MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQ---PGAQRMYKQSMAQRAR 57

Query: 49   TMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLAL 108
            TMALYNPIPVRQNC TVNRSLF+F EDN+VRKYAKK+ +WPPFEYMILATIIANCIVLAL
Sbjct: 58   TMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLAL 117

Query: 109  EQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV 168
            EQHLP+DDKTPMS RL+ TEPYFIGIFCFEAGIKI+ALGF FHKGSYLRNGWNVMDF+VV
Sbjct: 118  EQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVV 177

Query: 169  LSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLL 228
            L+GILAT GT F    DLRTLRAVRVLRPLKLVSGIPSLQ+VLKSIMKAM+PLLQIGLLL
Sbjct: 178  LTGILATVGTEF----DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLL 233

Query: 229  FFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGYECKD-WI 283
            FFAIL+FAIIGLEFY GK H  CF   +  ++G + P PCG +     CP G +C+  W 
Sbjct: 234  FFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQG-ESPAPCGTEEPARTCPNGTKCQPYWE 292

Query: 284  GPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVL 343
            GPN+GITQFDNILFAVLTVFQCITMEGWT +LYN+NDA G TWNWLYFIPLIIIGSFF+L
Sbjct: 293  GPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFML 352

Query: 344  NLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAG 403
            NLVLGVLSGEFAKERERVENRRAF+KLRRQQQIERELNGY  WI KAEEV+LAE+  +  
Sbjct: 353  NLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGE 412

Query: 404  TSAL--EVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHK 461
                    LRR TIK+S+T+ +  + +++   DI+SVG+P ARASIKSAK++  ++F  K
Sbjct: 413  QRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKK 472

Query: 462  ERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLL 521
            ER +R  IR MVK+Q FYW VLSLVALNT CVAIVH+NQP+WL+  LYYAEF+FLGLF+ 
Sbjct: 473  ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS 532

Query: 522  EMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFK 581
            EM +KMYG+G R YFHSSFNCFD GV +GSIFEV+WA+ +PGTSFGISVLRALRLLRIFK
Sbjct: 533  EMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFK 592

Query: 582  ITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFD 641
            +TKYWASLRNLVVSL++SMKSIISLLFLLFLFIVVFALLGMQLFGG+FNF++GTP  NFD
Sbjct: 593  VTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFD 652

Query: 642  TFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAI 701
            TFPAAIMTVFQILTGEDWNEVMY+GI+SQGGV  GM  +IYFIVLTLFGNYTLLNVFLAI
Sbjct: 653  TFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAI 712

Query: 702  AVDNLANAQELTKDEQEEEEAFNQKHALQKAKEV---SPMSAPNMPSI--ERDRRRRHHM 756
            AVDNLANAQELTKDEQEEEEA NQK ALQKAKEV   SP+SA NM     E+ + ++   
Sbjct: 713  AVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAK 772

Query: 757  SMWEPRSSHLRERRRR-------HHMSVWEQRTSQLRKHMQMSSQEALNREEA--PTMNP 807
            S+WE R+S +R++          + M   E+  +   +H++   +  L+R     P  N 
Sbjct: 773  SVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENR 832

Query: 808  LNPLNPLSSLNP--------------LNAHPSLYRRPRAIEGLALGLALEK----FEEER 849
             N  N   +  P              L      + R R   G A GL   +     +E  
Sbjct: 833  NNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSA-GLDARRPWAGSQEAE 891

Query: 850  ISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFE 909
            +SR G    +    +     ++     G+ E      P   +     ++ G  E+     
Sbjct: 892  LSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRH---VHRQGGSRESRSGSP 948

Query: 910  DRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKD------HELR 963
                  + +R   HRR   EG E  +  R+R     R    A   EGE +         R
Sbjct: 949  RTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRP---ARGGEGEGEGPDGGERRRR 1005

Query: 964  GNHGAKEPTIQEERAQDL-RRTNSLMVSRGSG-------------LAGGLDEADTPLVLP 1009
              HGA      + R +D  RR      ++GSG             +   L   D PL   
Sbjct: 1006 HRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAED 1065

Query: 1010 HPELEVGKHVVLTEQEPEGS-------SEQALLGNVQLDMGRVIS--------------- 1047
               ++  K        P GS          A +GN   D G +++               
Sbjct: 1066 IDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGN-STDPGPMLAIPAMATNPQNAASRR 1124

Query: 1048 -------------QSEPDLSCITANTDKATTESTSV-------TVAIPDV-DPLVDSTVV 1086
                            P+ S I  N     T S          TV IP    P ++ TVV
Sbjct: 1125 TPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVV 1184

Query: 1087 HISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETG-KAMVPHSSMFIFSTTNPIRRA 1145
             ++   + +  P KE E +E+EE+        ++ E G K M P+SSMFI STTNP+RR 
Sbjct: 1185 QVNKNANPDPLPKKEEEKKEEEED--------DRGEDGPKPMPPYSSMFILSTTNPLRRL 1236

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CHYI+NLRYFEMCIL+VIA SSIALAAEDPV  N+ RN VLRYFDYVFTGVFTFEMVIKM
Sbjct: 1237 CHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1296

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
            ID GL+L  G+YFRDLWNILDF+VV GALVAFA     G +KG+DI TIKSLRVLRVLRP
Sbjct: 1297 IDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFT---GNSKGKDINTIKSLRVLRVLRP 1353

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            LKTIKRLPKLKAVFDCVV SLKNVFNILIVY LFMFIFAV+AVQLFKGKFF+CTD SK+ 
Sbjct: 1354 LKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF 1413

Query: 1326 EKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVT 1385
            EK+C G Y+ +EKN+++ + REWK++EFHYDN++WALLTLFTVSTGEGWPQVL+HSVD T
Sbjct: 1414 EKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDAT 1473

Query: 1386 EEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERA 1445
             E++GPS   RMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEE SLEKNERA
Sbjct: 1474 FENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERA 1533

Query: 1446 CIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCT 1505
            CIDFAISAKPLTR+MPQN+ +FQYR+W FVVSP FEYTIMAMIALNT+VLMMK+Y A   
Sbjct: 1534 CIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVA 1593

Query: 1506 YELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLV 1565
            YE AL+  NI FT +FSLECVLKV+AFG LNYFRD WNIFDF+TV+GSIT+I++T+    
Sbjct: 1594 YENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE---F 1650

Query: 1566 NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1625
              +  N+SFL+LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG
Sbjct: 1651 GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1710

Query: 1626 MQVFGNIKLD--------EESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1677
            MQVFGNI +D        +E  I  HNNFR+FF +LMLLFRSATGEAW  IMLSCL  K 
Sbjct: 1711 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP 1770

Query: 1678 CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILG 1737
            C+ +    SG    E CG + AY YFVSFIF CSFLMLNLFVAVIMDNFEYLTRDSSILG
Sbjct: 1771 CDKN----SGILTRE-CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILG 1825

Query: 1738 PHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPV 1797
            PHHLDE+VRVWAEYD AACGRIHY +MY +L ++SPPLGLGK+CP +VA KRL+ M++PV
Sbjct: 1826 PHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPV 1885

Query: 1798 AEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPM 1857
            A+D TVHF STLMALIRTALDIKIAKGGAD+QQ+D+EL+KE +AIWP+LSQK LDLLV  
Sbjct: 1886 ADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTP 1945

Query: 1858 PKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAP-MFQRMEPSSLPQEIIANAK 1916
             K++DLTVGKIYAAMMIM+YY+QSK KK +   EEQ   P MFQRMEP S  QE      
Sbjct: 1946 HKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQN 2005

Query: 1917 ALPYLQQDPVSGL----SGRSGYPSMSPLSPQDIFQ------------------------ 1948
            ALP  Q DP   L    SG    PS      Q++FQ                        
Sbjct: 2006 ALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQS 2065

Query: 1949 LACMDPADDG----------QFQERQSLVVTDPSSMRR--------SFSTIRD----KRS 1986
            +   +   DG          + Q R + +   P+  +R        + STI D    KRS
Sbjct: 2066 VEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRS 2125

Query: 1987 NS------SWLEEFSMER-----SSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSD---T 2032
             S        L+++S+ER     +  +  + R RS+ +S R      + D+G  +D   T
Sbjct: 2126 ASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMT 2185

Query: 2033 HRSG-------GRERGRSKERKHLL------------SPDVSRCNSEERGTQADWESPER 2073
             +SG        +ERGR K+RKH               PD  R  ++ER       + ++
Sbjct: 2186 TQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDR-YAQERPDHGRARARDQ 2244

Query: 2074 RQSRSPSEGRSQTPNRQ 2090
            R SRSPSEGR    +RQ
Sbjct: 2245 RWSRSPSEGREHMAHRQ 2261


>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
            subunit [Homo sapiens]
          Length = 2339

 Score = 2283 bits (5916), Expect = 0.0
 Identities = 1329/2390 (55%), Positives = 1556/2390 (65%), Gaps = 225/2390 (9%)

Query: 1    MARFGEAVVAR---PGSGDGDSDQSRNRQGTPVPAS---GQAAAYKQTKAQRARTMALYN 54
            M RFG+ +  R   PG G+          G P P     GQ   YKQ+ AQRARTMALYN
Sbjct: 1    MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN 60

Query: 55   PIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPE 114
            PIPV+QNCFTVNRSLF+F EDN+VRKYAK++ +WPPFEYMILATIIANCIVLALEQHLP+
Sbjct: 61   PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD 120

Query: 115  DDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILA 174
             DKTPMS RL+ TEPYFIGIFCFEAGIKI+ALGF+FHKGSYLRNGWNVMDF+VVL+GILA
Sbjct: 121  GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA 180

Query: 175  TAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILM 234
            TAGT F    DLRTLRAVRVLRPLKLVSGIPSLQ+VLKSIMKAMVPLLQIGLLLFFAILM
Sbjct: 181  TAGTDF----DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236

Query: 235  FAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGYECKD-WIGPNDGI 289
            FAIIGLEFY GK H+ACF N++      D   PCG +     C    EC++ W GPN GI
Sbjct: 237  FAIIGLEFYMGKFHKACFPNSTDAEPVGD--FPCGKEAPARLCEGDTECREYWPGPNFGI 294

Query: 290  TQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGV 349
            T FDNILFA+LTVFQCITMEGWT +LYNTNDA G TWNWLYFIPLIIIGSFF+LNLVLGV
Sbjct: 295  TNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGV 354

Query: 350  LSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGT-SALE 408
            LSGEFAKERERVENRRAF+KLRRQQQIERELNGY  WI KAEEVMLAEE++NA   S L+
Sbjct: 355  LSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLD 414

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
            VL+RA  K+SR + +  +  ++   D+ +VG+P ARAS+KS K +  SYFR KE++ R  
Sbjct: 415  VLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFF 474

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            IR MVK+Q FYW+VL +VALNT CVA+VH+NQP+ LT  LY+AEF+FLGLFL EMSLKMY
Sbjct: 475  IRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMY 534

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWAS 588
            G+GPR YF SSFNCFDFGV VGS+FEVVWA  +PG+SFGISVLRALRLLRIFK+TKYW+S
Sbjct: 535  GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594

Query: 589  LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
            LRNLVVSL++SMKSIISLLFLLFLFIVVFALLGMQLFGG+FNF D TP+ NFDTFPAAI+
Sbjct: 595  LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654

Query: 649  TVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLAN 708
            TVFQILTGEDWN VMY+GI SQGGVS GM+S+ YFIVLTLFGNYTLLNVFLAIAVDNLAN
Sbjct: 655  TVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLAN 714

Query: 709  AQELTKDEQEEEEAFNQKHALQKAKEV---SPMSAPNMPSIERDRRRRHHMSMWEPRSSH 765
            AQELTKDE+E EEA NQK ALQKAKEV   SPMSA N+                   S  
Sbjct: 715  AQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANI-------------------SIA 755

Query: 766  LRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAP-------TMNPLNPLNPLSSLN 818
             R++      SVWEQR SQLR     +S EAL  E  P       T   L P        
Sbjct: 756  ARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDR 815

Query: 819  PLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQ 878
            PL            + G A   A E  E     R      D     +A D  R      +
Sbjct: 816  PLVVELGRDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAE 875

Query: 879  REPPWL----ARPCHGN----CDPTQQEAGGGEAVVTFEDRARHRQSQ---------RRS 921
               P       RP   +      P +  +  G        R  HR+           RR 
Sbjct: 876  SGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRH 935

Query: 922  RHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDL 981
            R  R +   KE + A   R A + R    A P E E   E    H A+        A + 
Sbjct: 936  RAHRHQDPSKECAGAKGERRA-RHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEK 994

Query: 982  RRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLD 1041
              T                E +  +V    E E+  H     +EP    E +  G V   
Sbjct: 995  ETTEK-----------EATEKEAEIVEADKEKELRNH---QPREPHCDLETS--GTV--T 1036

Query: 1042 MGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKE 1101
            +G + +     L  +    + A  +     +     DP   +T+VHI     G   PL E
Sbjct: 1037 VGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDP---NTIVHIPVMLTG---PLGE 1090

Query: 1102 AEI-------REDEEEVEKKKQKKEKRETG-KAMVPHSSMFIFSTTNPIRRACHYIVNLR 1153
            A +        E + E +K+ +  +   +G + +VP+SSMF  S TN +RR CHYIV +R
Sbjct: 1091 ATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMR 1150

Query: 1154 YFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQ 1213
            YFE+ IL+VIA SSIALAAEDPV T+S RN  L+Y DY+FTGVFTFEMVIKMID GL+L 
Sbjct: 1151 YFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLH 1210

Query: 1214 DGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLP 1273
             G+YFRDLWNILDF+VV GALVAFA +     +KG+DI TIKSLRVLRVLRPLKTIKRLP
Sbjct: 1211 PGAYFRDLWNILDFIVVSGALVAFAFSG----SKGKDINTIKSLRVLRVLRPLKTIKRLP 1266

Query: 1274 KLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNY 1333
            KLKAVFDCVV SLKNV NILIVY LFMFIFAVIAVQLFKGKFFYCTD SK+ E++C G Y
Sbjct: 1267 KLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQY 1326

Query: 1334 VDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSR 1393
            +D+EK ++E + R+WK+++FHYDN++WALLTLFTVSTGEGWP VL+HSVD T E++GPS 
Sbjct: 1327 LDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSP 1386

Query: 1394 SNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISA 1453
              RME+SIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK+M ECSLEKNERACIDFAISA
Sbjct: 1387 GYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISA 1446

Query: 1454 KPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYL 1513
            KPLTRYMPQNR +FQY+ W FVVSP FEY IMAMIALNTVVLMMK+Y AP  YEL LK L
Sbjct: 1447 KPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCL 1506

Query: 1514 NIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGF-NM 1572
            NI FT +FS+ECVLK+IAFG LNYFRD WN+FDF+TV+GSIT+I++T+  +  T+ F N+
Sbjct: 1507 NIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTE--IAETNNFINL 1564

Query: 1573 SFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1632
            SFL+LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI
Sbjct: 1565 SFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1624

Query: 1633 KLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENE 1692
             LD+++ INRHNNFR+F  +LMLLFRSATGEAW EIMLSCL  + C+    A        
Sbjct: 1625 ALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANA-------T 1677

Query: 1693 RCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYD 1752
             CG+D AY YFVSFIF CSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEF+RVWAEYD
Sbjct: 1678 ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYD 1737

Query: 1753 RAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVA-EDMTVHFTSTLMA 1811
             AACGRI Y +M+EML  MSPPLGLGK+CP++VAYKRLV MNMP++ EDMTVHFTSTLMA
Sbjct: 1738 PAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMA 1797

Query: 1812 LIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAA 1871
            LIRTAL+IK+A  G  + Q D+EL+KE   +W +L QK LDLLVP  K  ++TVGK+YAA
Sbjct: 1798 LIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAA 1857

Query: 1872 MMIMDYYKQSKVKKQRQQ-----LEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPV 1926
            +MI D+YKQ+K  + + Q     L +     +F  ++ +    +      A  +L+Q   
Sbjct: 1858 LMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSS 1917

Query: 1927 SGL----------SGRSGYPSMSPLSPQDIFQLACMDPADDGQFQE-------------- 1962
            + L          SG     S      QD    A   P + G   E              
Sbjct: 1918 TSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEA-RPPLERGHSTEIPVGRSGALAVDVQ 1976

Query: 1963 RQSLVVTDP--------SSMRRSFSTIRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSS 2014
             QS+    P         S  R+ S  R         +   M+RS  +T   R R  H  
Sbjct: 1977 MQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSI-STLAQRPRGTHLC 2035

Query: 2015 LRLSAHRLNSDSGHKSDTHRSGGR--ERGRSKERKHLLSPDVSRCNSEERGTQADWESPE 2072
                     S +      HR   R   + RS E+   LS D+    S   G       P 
Sbjct: 2036 STTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVG-------PG 2088

Query: 2073 RRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPR--RSRRQLPPVPPKPRPLLSYS 2130
                  P+  R +   RQ  G   E   PS S +   R     R     PPKP+P LS  
Sbjct: 2089 LPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSH 2148

Query: 2131 SLIRHAG---SISPPADGSEEGSPLTSQALES-----NNACLTESSNSPHPQ---QSQHA 2179
                 AG      P   GS  GSPL S +  S         L ++  +P P    ++ ++
Sbjct: 2149 PTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANS 2208

Query: 2180 SP-----------------------------------------QRYISEPYLALHEDSHA 2198
            SP                                          R  S+PYL    DS A
Sbjct: 2209 SPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEA 2268

Query: 2199 S-DCGEEETLTFEAAVATSLGR-------SNTIGSAPPLRHSWQMPNGHY 2240
            S     E+TLTFE AVAT+ GR       S+    + PLR   ++PNG++
Sbjct: 2269 SVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLR---RVPNGYH 2315


>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 19 [Homo sapiens]
          Length = 2135

 Score =  751 bits (1938), Expect = 0.0
 Identities = 391/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 830  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 889

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 890  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 949

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 950  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1002

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1003 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1062

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1063 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1122

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1123 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1182

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1183 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1240

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF    YF D WN+FDF+ VIGSI ++IL+++
Sbjct: 1241 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSET 1300

Query: 1563 KLVN------------TSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                             S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1301 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1360

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1361 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1420

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1421 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1479

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1480 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1539

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1540 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1596

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1597 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1649



 Score =  630 bits (1625), Expect = e-180
 Identities = 359/752 (47%), Positives = 467/752 (62%), Gaps = 34/752 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILEGFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLTVF 303
            C+ N  GI    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LTVF
Sbjct: 297 TCY-NQEGIAAE-DDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVF 354

Query: 304 QCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVEN 363
           QCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ + 
Sbjct: 355 QCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKA 414

Query: 364 RRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAM 423
           R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE++
Sbjct: 415 RGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETESV 471

Query: 424 TRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVL 483
             ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+V+
Sbjct: 472 NTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWLVI 528

Query: 484 SLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCF 543
            LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN F
Sbjct: 529 FLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRF 588

Query: 544 DFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSI 603
           D  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++SI
Sbjct: 589 DCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSI 648

Query: 604 ISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWNEV 662
            SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN V
Sbjct: 649 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSV 708

Query: 663 MYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 721
           MY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EEEE
Sbjct: 709 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEE 768

Query: 722 AFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
              +K   + A           P++   +  +
Sbjct: 769 EKERKKLARTASPEKKQELVEKPAVGESKEEK 800



 Score =  222 bits (565), Expect = 4e-57
 Identities = 185/704 (26%), Positives = 330/704 (46%), Gaps = 121/704 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTD----SSKDTEKEC 1329
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +    +++D    C
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPC 313

Query: 1330 ---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSVDVT 1385
                G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    D  
Sbjct: 314  ALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAV 373

Query: 1386 EEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMMEE 1436
              D            I++V   ++  FF +N+ + ++   F ++       GD  K+ E+
Sbjct: 374  GRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK 424

Query: 1437 CSLEKNERACIDFAISA---------------KPLTRYMP-------------------- 1461
              LE++ +  +D+   A               KP    MP                    
Sbjct: 425  QQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGE 484

Query: 1462 -----------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMKYYS 1501
                       +++ +  +R W+          V S  F + ++ ++ LNT+ +  ++Y+
Sbjct: 485  NCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYN 544

Query: 1502 APCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD 1561
             P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E IL +
Sbjct: 545  QPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVE 604

Query: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
            +K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +   I+
Sbjct: 605  TKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 662

Query: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
            +++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G    
Sbjct: 663  SLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG---- 717

Query: 1682 TTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
               PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 718  --GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 752



 Score =  199 bits (507), Expect = 2e-50
 Identities = 173/698 (24%), Positives = 307/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 876  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 933

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 934  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 992

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 993  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1052

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1053 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1100

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1101 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1160

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1161 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1179

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1180 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1208

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1209 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1268

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF   +N FDF + +GSI +V+ +   P               +   I+  R  
Sbjct: 1269 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLF 1328

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1329 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1387

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1388 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1447

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1448 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1482



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 523  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 577

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 578  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 635

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 636  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 682

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 683  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 722

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 723  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 782

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 783  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 838

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 839  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 898

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 899  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 956

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 957  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1013

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1014 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1073

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1074 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1133

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1134 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1185

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1186 CVEYALKARPL 1196



 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 74/299 (24%), Positives = 130/299 (43%), Gaps = 71/299 (23%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------GN 1631
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F            G 
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1632 IKLDEESHIN----------------------RHN--NFRSFFGSLMLLFRSATGEAWQE 1667
               D+ S                         +H   NF +F  +++ +F+  T E W +
Sbjct: 305  AAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTD 364

Query: 1668 IMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
            ++                     N+  G D  ++YFV+ I   SF +LNL + V+   F
Sbjct: 365  VLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405


>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 16 [Homo sapiens]
          Length = 2138

 Score =  751 bits (1938), Expect = 0.0
 Identities = 391/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF    YF D WN+FDF+ VIGSI ++IL+++
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSET 1303

Query: 1563 KLVN------------TSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                             S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1599

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1652



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  199 bits (507), Expect = 2e-50
 Identities = 173/698 (24%), Positives = 307/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF   +N FDF + +GSI +V+ +   P               +   I+  R  
Sbjct: 1272 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 15 [Homo sapiens]
          Length = 2138

 Score =  749 bits (1935), Expect = 0.0
 Identities = 390/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF    YF D WN+FDF+ VIGSI ++IL+++
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSET 1303

Query: 1563 KLVN------------TSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                             S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1599

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1652



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  201 bits (510), Expect = 9e-51
 Identities = 173/698 (24%), Positives = 307/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF   +N FDF + +GSI +V+ +   P               +   I+  R  
Sbjct: 1272 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 20 [Homo sapiens]
          Length = 2127

 Score =  748 bits (1932), Expect = 0.0
 Identities = 388/822 (47%), Positives = 544/822 (66%), Gaps = 27/822 (3%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
            +     S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIY
Sbjct: 1304 NNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1363

Query: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
            A+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P+
Sbjct: 1364 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1423

Query: 1682 TTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740
            +  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1424 SE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1482

Query: 1741 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED 1800
            LDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D
Sbjct: 1483 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1542

Query: 1801 MTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKA 1860
             TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K+LD +VP    
Sbjct: 1543 GTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1599

Query: 1861 SDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
             ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1641



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  197 bits (501), Expect = 1e-49
 Identities = 171/687 (24%), Positives = 304/687 (44%), Gaps = 130/687 (18%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIF---RPGTSFGISVLRALRLLRIFKITKY 585
               P+ YF  ++N FD  + VGSI ++           +   I+  R  R++R+ K+   
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1331

Query: 586  WASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDT 642
               +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND T    + NF T
Sbjct: 1332 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQT 1390

Query: 643  FPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-MWSAIYFIVLTL 688
            FP A++ +F+  TGE W ++M   +              ++G    G  ++  YFI   +
Sbjct: 1391 FPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYM 1450

Query: 689  FGNYTLLNVFLAIAVDNLANAQELTKD 715
               + ++N+F+A+ +DN      LT+D
Sbjct: 1451 LCAFLIINLFVAVIMDNF---DYLTRD 1474



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoforom 13 [Homo sapiens]
          Length = 2144

 Score =  748 bits (1932), Expect = 0.0
 Identities = 391/837 (46%), Positives = 547/837 (65%), Gaps = 40/837 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T++
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEN 1303

Query: 1563 KLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1622
               N S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA
Sbjct: 1304 AEEN-SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1362

Query: 1623 IIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDT 1682
            +IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P++
Sbjct: 1363 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPES 1422

Query: 1683 TAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHL 1741
              PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHHL
Sbjct: 1423 E-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL 1481

Query: 1742 DEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDM 1801
            DEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D 
Sbjct: 1482 DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDG 1541

Query: 1802 TVHFTSTLMALIRTALDIKIAKG----------------GADRQQLDSELQKETLAIWPH 1845
            TV F +TL AL+RTAL IK  +G                  + +Q + EL+     IW  
Sbjct: 1542 TVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKR 1601

Query: 1846 LSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
             S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1602 TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1658



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  197 bits (502), Expect = 7e-50
 Identities = 171/685 (24%), Positives = 305/685 (44%), Gaps = 128/685 (18%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEV-VWAIFRPGTSFGISVLRALRLLRIFKITKYWA 587
               P+ YF  ++N FD  + VGSI ++ +       +   I+  R  R++R+ K+     
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLLSRGE 1331

Query: 588  SLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFP 644
             +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND T    + NF TFP
Sbjct: 1332 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFP 1390

Query: 645  AAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-MWSAIYFIVLTLFG 690
             A++ +F+  TGE W ++M   +              ++G    G  ++  YFI   +  
Sbjct: 1391 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLC 1450

Query: 691  NYTLLNVFLAIAVDNLANAQELTKD 715
             + ++N+F+A+ +DN      LT+D
Sbjct: 1451 AFLIINLFVAVIMDNF---DYLTRD 1472



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 7 [Homo sapiens]
          Length = 2157

 Score =  748 bits (1932), Expect = 0.0
 Identities = 392/849 (46%), Positives = 548/849 (64%), Gaps = 51/849 (6%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF    YF D WN+FDF+ VIGSI ++IL+++
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSET 1303

Query: 1563 KLVN------------TSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                             S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKG----------------GADRQQLDS 1833
            LV MNMP+  D TV F +TL AL+RTAL IK  +G                  + +Q + 
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANE 1602

Query: 1834 ELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--E 1891
            EL+     IW   S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +   
Sbjct: 1603 ELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKP 1662

Query: 1892 EQKNAPMFQ 1900
             Q+NA   Q
Sbjct: 1663 SQRNALSLQ 1671



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  199 bits (507), Expect = 2e-50
 Identities = 173/698 (24%), Positives = 307/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF   +N FDF + +GSI +V+ +   P               +   I+  R  
Sbjct: 1272 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 11 [Homo sapiens]
          Length = 2146

 Score =  747 bits (1929), Expect = 0.0
 Identities = 390/838 (46%), Positives = 546/838 (65%), Gaps = 40/838 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
            +     S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIY
Sbjct: 1304 NNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1363

Query: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
            A+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P+
Sbjct: 1364 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1423

Query: 1682 TTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740
            +  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1424 SE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1482

Query: 1741 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED 1800
            LDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D
Sbjct: 1483 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1542

Query: 1801 MTVHFTSTLMALIRTALDIKIAKG----------------GADRQQLDSELQKETLAIWP 1844
             TV F +TL AL+RTAL IK  +G                  + +Q + EL+     IW 
Sbjct: 1543 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWK 1602

Query: 1845 HLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
              S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1603 RTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1660



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  196 bits (498), Expect = 2e-49
 Identities = 171/687 (24%), Positives = 304/687 (44%), Gaps = 130/687 (18%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIF---RPGTSFGISVLRALRLLRIFKITKY 585
               P+ YF  ++N FD  + VGSI ++           +   I+  R  R++R+ K+   
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1331

Query: 586  WASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDT 642
               +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND T    + NF T
Sbjct: 1332 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQT 1390

Query: 643  FPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-MWSAIYFIVLTL 688
            FP A++ +F+  TGE W ++M   +              ++G    G  ++  YFI   +
Sbjct: 1391 FPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYM 1450

Query: 689  FGNYTLLNVFLAIAVDNLANAQELTKD 715
               + ++N+F+A+ +DN      LT+D
Sbjct: 1451 LCAFLIINLFVAVIMDNF---DYLTRD 1474



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 12 [Homo sapiens]
          Length = 2146

 Score =  746 bits (1926), Expect = 0.0
 Identities = 389/838 (46%), Positives = 546/838 (65%), Gaps = 40/838 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
            +     S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIY
Sbjct: 1304 NNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1363

Query: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
            A+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P+
Sbjct: 1364 AVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1423

Query: 1682 TTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740
            +  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHH
Sbjct: 1424 SE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1482

Query: 1741 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAED 1800
            LDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D
Sbjct: 1483 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1542

Query: 1801 MTVHFTSTLMALIRTALDIKIAKG----------------GADRQQLDSELQKETLAIWP 1844
             TV F +TL AL+RTAL IK  +G                  + +Q + EL+     IW 
Sbjct: 1543 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWK 1602

Query: 1845 HLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
              S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1603 RTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1660



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  197 bits (501), Expect = 1e-49
 Identities = 171/687 (24%), Positives = 304/687 (44%), Gaps = 130/687 (18%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIF---RPGTSFGISVLRALRLLRIFKITKY 585
               P+ YF  ++N FD  + VGSI ++           +   I+  R  R++R+ K+   
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1331

Query: 586  WASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDT 642
               +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND T    + NF T
Sbjct: 1332 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQT 1390

Query: 643  FPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-MWSAIYFIVLTL 688
            FP A++ +F+  TGE W ++M   +              ++G    G  ++  YFI   +
Sbjct: 1391 FPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYM 1450

Query: 689  FGNYTLLNVFLAIAVDNLANAQELTKD 715
               + ++N+F+A+ +DN      LT+D
Sbjct: 1451 LCAFLIINLFVAVIMDNF---DYLTRD 1474



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 18 [Homo sapiens]
          Length = 2138

 Score =  745 bits (1923), Expect = 0.0
 Identities = 391/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 --------SKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                    S  +N    S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1599

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1652



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  195 bits (495), Expect = 5e-49
 Identities = 172/698 (24%), Positives = 305/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF  ++N FD  + VGSI ++      P               +   I+  R  
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 4 [Homo sapiens]
          Length = 2173

 Score =  744 bits (1920), Expect = 0.0
 Identities = 390/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 --------SKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                    S  +N    S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1599

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1652



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  196 bits (498), Expect = 2e-49
 Identities = 172/698 (24%), Positives = 305/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF  ++N FD  + VGSI ++      P               +   I+  R  
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 17 [Homo sapiens]
          Length = 2138

 Score =  744 bits (1920), Expect = 0.0
 Identities = 390/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 --------SKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                    S  +N    S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1599

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1652



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  196 bits (498), Expect = 2e-49
 Identities = 172/698 (24%), Positives = 305/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF  ++N FD  + VGSI ++      P               +   I+  R  
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 14 [Homo sapiens]
          Length = 2138

 Score =  744 bits (1920), Expect = 0.0
 Identities = 390/833 (46%), Positives = 546/833 (65%), Gaps = 38/833 (4%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 --------SKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                    S  +N    S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQK 1849
            LV MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMK 1599

Query: 1850 MLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            +LD +VP     ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1600 LLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1652



 Score =  620 bits (1600), Expect = e-177
 Identities = 355/754 (47%), Positives = 465/754 (61%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY   DA+G    W+YF+ L+I GSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  219 bits (558), Expect = 2e-56
 Identities = 188/708 (26%), Positives = 330/708 (46%), Gaps = 126/708 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQ 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--K 1432
            D          +   E+   Y V  V+F  FFV N+ + ++   F ++       GD  K
Sbjct: 374  D----------AMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK 423

Query: 1433 MMEECSLEKNERACIDFAISA---------------KPLTRYMP---------------- 1461
            + E+  LE++ +  +D+   A               KP    MP                
Sbjct: 424  LREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGD 483

Query: 1462 ---------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMM 1497
                           +++ +  +R W+          V S  F + ++ ++ LNT+ +  
Sbjct: 484  IEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIAS 543

Query: 1498 KYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEI 1557
            ++Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E 
Sbjct: 544  EHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILET 603

Query: 1558 ILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1617
            IL ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ + 
Sbjct: 604  ILVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLF 661

Query: 1618 FFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1677
              I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G
Sbjct: 662  IIIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG 720

Query: 1678 CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                   PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  ------GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  196 bits (498), Expect = 2e-49
 Identities = 172/698 (24%), Positives = 305/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF  ++N FD  + VGSI ++      P               +   I+  R  
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 73/302 (24%), Positives = 132/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                      +  G +L +VYFVS + F SF +LNL + V+  
Sbjct: 365  WTDVLYWM------------------QDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 10 [Homo sapiens]
          Length = 2155

 Score =  743 bits (1918), Expect = 0.0
 Identities = 390/850 (45%), Positives = 546/850 (64%), Gaps = 55/850 (6%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF    YF D WN+FDF+ VIGSI ++IL+++
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSET 1303

Query: 1563 K-----------------------------LVNTSGFNMSFLKLFRAARLIKLLRQGYTI 1593
                                              S  +++F +LFR  RL+KLL +G  I
Sbjct: 1304 NHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGI 1363

Query: 1594 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSL 1653
            R LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  ++
Sbjct: 1364 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV 1423

Query: 1654 MLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSF 1712
            +LLFR ATGEAWQ+IML+C+  K C P++  PS   E E  CG+  A  YF+SF   C+F
Sbjct: 1424 LLLFRCATGEAWQDIMLACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAF 1482

Query: 1713 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMS 1772
            L++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + 
Sbjct: 1483 LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1542

Query: 1773 PPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLD 1832
            PPLG GK CP +VA KRLV MNMP+  D TV F +TL AL+RTAL IK      + +Q +
Sbjct: 1543 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLEQAN 1599

Query: 1833 SELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL-- 1890
             EL+     IW   S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +  
Sbjct: 1600 EELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK 1659

Query: 1891 EEQKNAPMFQ 1900
              Q+NA   Q
Sbjct: 1660 PSQRNALSLQ 1669



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  194 bits (494), Expect = 6e-49
 Identities = 174/715 (24%), Positives = 307/715 (42%), Gaps = 158/715 (22%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVV-----------WAIF----------------- 560
               P+ YF   +N FDF + +GSI +V+           W  F                 
Sbjct: 1272 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEV 1331

Query: 561  ---RPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVF 617
                  +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++
Sbjct: 1332 NNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1391

Query: 618  ALLGMQLFGGRFNFNDGTP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI------- 667
            A++GMQ+F G+   ND T    + NF TFP A++ +F+  TGE W ++M   +       
Sbjct: 1392 AVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1450

Query: 668  ------RSQGGVSSG-MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
                   ++G    G  ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1502



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 8 [Homo sapiens]
          Length = 2157

 Score =  743 bits (1917), Expect = 0.0
 Identities = 392/849 (46%), Positives = 548/849 (64%), Gaps = 51/849 (6%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 --------SKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                    S  +N    S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKG----------------GADRQQLDS 1833
            LV MNMP+  D TV F +TL AL+RTAL IK  +G                  + +Q + 
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANE 1602

Query: 1834 ELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--E 1891
            EL+     IW   S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +   
Sbjct: 1603 ELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKP 1662

Query: 1892 EQKNAPMFQ 1900
             Q+NA   Q
Sbjct: 1663 SQRNALSLQ 1671



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  195 bits (495), Expect = 5e-49
 Identities = 172/698 (24%), Positives = 305/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF  ++N FD  + VGSI ++      P               +   I+  R  
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 9 [Homo sapiens]
          Length = 2157

 Score =  741 bits (1914), Expect = 0.0
 Identities = 391/849 (46%), Positives = 548/849 (64%), Gaps = 51/849 (6%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L   DYVFT +FT E+++KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 --------SKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
                    S  +N    S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV
Sbjct: 1304 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1363

Query: 1611 CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIML 1670
             LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML
Sbjct: 1364 ALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIML 1423

Query: 1671 SCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYL 1729
            +C+  K C P++  PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YL
Sbjct: 1424 ACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYL 1482

Query: 1730 TRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKR 1789
            TRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KR
Sbjct: 1483 TRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKR 1542

Query: 1790 LVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKG----------------GADRQQLDS 1833
            LV MNMP+  D TV F +TL AL+RTAL IK  +G                  + +Q + 
Sbjct: 1543 LVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANE 1602

Query: 1834 ELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQL--E 1891
            EL+     IW   S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  +   
Sbjct: 1603 ELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKP 1662

Query: 1892 EQKNAPMFQ 1900
             Q+NA   Q
Sbjct: 1663 SQRNALSLQ 1671



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  196 bits (498), Expect = 2e-49
 Identities = 172/698 (24%), Positives = 305/698 (43%), Gaps = 141/698 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILGNA 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP--------------GTSFGISVLRAL 574
               P+ YF  ++N FD  + VGSI ++      P               +   I+  R  
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLF 1331

Query: 575  RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 634
            R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND 
Sbjct: 1332 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDT 1390

Query: 635  TP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-M 677
            T    + NF TFP A++ +F+  TGE W ++M   +              ++G    G  
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450

Query: 678  WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
            ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1485



 Score =  133 bits (335), Expect = 2e-30
 Identities = 155/731 (21%), Positives = 302/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L  A+++F  +F LE+ LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILGNADYVFTSIFTLEIILKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 5 [Homo sapiens]
          Length = 2166

 Score =  740 bits (1910), Expect = 0.0
 Identities = 391/861 (45%), Positives = 546/861 (63%), Gaps = 66/861 (7%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
             C +++A+  LN+ FT +F++E +LK+IAF    YF D WN+FDF+ VIGSI ++IL+++
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSET 1303

Query: 1563 K----------------------------------------LVNTSGFNMSFLKLFRAAR 1582
                                                         S  +++F +LFR  R
Sbjct: 1304 NHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMR 1363

Query: 1583 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINR 1642
            L+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I L++ + INR
Sbjct: 1364 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1423

Query: 1643 HNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER-CGTDLAYV 1701
            +NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P++  PS   E E  CG+  A  
Sbjct: 1424 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE-PSNSTEGETPCGSSFAVF 1482

Query: 1702 YFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHY 1761
            YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYD  A GRI +
Sbjct: 1483 YFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKH 1542

Query: 1762 TEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKI 1821
             ++  +L  + PPLG GK CP +VA KRLV MNMP+  D TV F +TL AL+RTAL IK 
Sbjct: 1543 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKT 1602

Query: 1822 AKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQS 1881
                 + +Q + EL+     IW   S K+LD +VP     ++TVGK YA  +I +Y+++ 
Sbjct: 1603 E---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKF 1659

Query: 1882 KVKKQRQQL--EEQKNAPMFQ 1900
            K +K++  +    Q+NA   Q
Sbjct: 1660 KKRKEQGLVGKPSQRNALSLQ 1680



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  189 bits (480), Expect = 3e-47
 Identities = 174/726 (23%), Positives = 307/726 (42%), Gaps = 169/726 (23%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVV-----------WAIF----------------- 560
               P+ YF   +N FDF + +GSI +V+           W  F                 
Sbjct: 1272 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEV 1331

Query: 561  --------------RPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISL 606
                             +   I+  R  R++R+ K+      +R L+ + + S +++  +
Sbjct: 1332 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV 1391

Query: 607  LFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPAAIMTVFQILTGEDWNEVM 663
              L+ +   ++A++GMQ+F G+   ND T    + NF TFP A++ +F+  TGE W ++M
Sbjct: 1392 ALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM 1450

Query: 664  YNGI-------------RSQGGVSSG-MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANA 709
               +              ++G    G  ++  YFI   +   + ++N+F+A+ +DN    
Sbjct: 1451 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF--- 1507

Query: 710  QELTKD 715
              LT+D
Sbjct: 1508 DYLTRD 1513



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 6 [Homo sapiens]
          Length = 2158

 Score =  738 bits (1905), Expect = 0.0
 Identities = 392/853 (45%), Positives = 548/853 (64%), Gaps = 58/853 (6%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD--------------- 1190
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD               
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKI 952

Query: 1191 -----YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGT 1245
                 YVFT +FT E+++KM   G  L  GS+ R+ +NILD +VV  +L++F + ++   
Sbjct: 953  LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-- 1010

Query: 1246 NKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAV 1305
                 I  +K LRVLRVLRPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA 
Sbjct: 1011 -----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065

Query: 1306 IAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWAL 1362
            I VQLFKGK + C+DSSK TE EC GNY+ ++  +++   ++ R W+  +F +DN++ A+
Sbjct: 1066 IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAM 1125

Query: 1363 LTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALI 1422
            + LFTVST EGWP++L  S+D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +
Sbjct: 1126 MALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV 1185

Query: 1423 IITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEY 1482
            I+TFQEQG++  + C L+KN+R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY
Sbjct: 1186 IVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEY 1243

Query: 1483 TIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTW 1542
             +  +I LNT+ L M++Y   C +++A+  LN+ FT +F++E +LK+IAF   +YF D W
Sbjct: 1244 LMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAW 1303

Query: 1543 NIFDFITVIGSITEIILTD---------SKLVNT---SGFNMSFLKLFRAARLIKLLRQG 1590
            N FD + V+GSI +I +T+         S  +N    S  +++F +LFR  RL+KLL +G
Sbjct: 1304 NTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRG 1363

Query: 1591 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFF 1650
              IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++F 
Sbjct: 1364 EGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFP 1423

Query: 1651 GSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFIFF 1709
             +++LLFR ATGEAWQ+IML+C+  K C P++  PS   E E  CG+  A  YF+SF   
Sbjct: 1424 QAVLLLFRCATGEAWQDIMLACMPGKKCAPESE-PSNSTEGETPCGSSFAVFYFISFYML 1482

Query: 1710 CSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLT 1769
            C+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYD  A GRI + ++  +L 
Sbjct: 1483 CAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLR 1542

Query: 1770 LMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQ 1829
             + PPLG GK CP +VA KRLV MNMP+  D TV F +TL AL+RTAL IK      + +
Sbjct: 1543 RIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTE---GNLE 1599

Query: 1830 QLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQ 1889
            Q + EL+     IW   S K+LD +VP     ++TVGK YA  +I +Y+++ K +K++  
Sbjct: 1600 QANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL 1659

Query: 1890 L--EEQKNAPMFQ 1900
            +    Q+NA   Q
Sbjct: 1660 VGKPSQRNALSLQ 1672



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  186 bits (473), Expect = 2e-46
 Identities = 173/716 (24%), Positives = 306/716 (42%), Gaps = 157/716 (21%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALE---QHLPEDDKTPMS--- 121
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   QH    +        
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938

Query: 122  ------------RRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL 169
                        + L   +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV 
Sbjct: 939  VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV- 997

Query: 170  SGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLF 229
            S  L + G   +    ++ LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++  
Sbjct: 998  SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057

Query: 230  FAILMFAIIGLEFYSGKLHRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYEC 279
                MFA IG++ + GKL+            C  N     +G +  HP          + 
Sbjct: 1058 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQP 1108

Query: 280  KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LY 330
            + W    +    FDN+L A++ +F   T EGW  +LY + D+     G  +N+     ++
Sbjct: 1109 RSW---ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1165

Query: 331  FIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKA 390
            FI  III +FF++N+ +G                  F+ +  Q+Q E+E           
Sbjct: 1166 FIIYIIIIAFFMMNIFVG------------------FVIVTFQEQGEQEYKNCEL----- 1202

Query: 391  EEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSA 450
                                               D +   CV+ +    PL R   K+ 
Sbjct: 1203 -----------------------------------DKNQRQCVEYALKARPLRRYIPKN- 1226

Query: 451  KVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYY 510
                    +H+ +     + ++V S  F +++  L+ LNT C+A+ H+ Q       +  
Sbjct: 1227 --------QHQYK-----VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNI 1273

Query: 511  AEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRP-------- 562
               LF GLF +EM LK+    P+ YF  ++N FD  + VGSI ++      P        
Sbjct: 1274 LNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSP 1333

Query: 563  ------GTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVV 616
                   +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +   +
Sbjct: 1334 SMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1393

Query: 617  FALLGMQLFGGRFNFNDGTP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI------ 667
            +A++GMQ+F G+   ND T    + NF TFP A++ +F+  TGE W ++M   +      
Sbjct: 1394 YAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCA 1452

Query: 668  -------RSQGGVSSG-MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
                    ++G    G  ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1453 PESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1505



 Score =  127 bits (319), Expect = 1e-28
 Identities = 156/751 (20%), Positives = 304/751 (40%), Gaps = 160/751 (21%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYY--------------------AEFL 514
            F  ++L  + L++  +A    V H    +  H+L+Y                    A+++
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKILGNADYV 959

Query: 515  FLGLFLLEMSLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISV 570
            F  +F LE+ LKM   G  L    +  + FN  D  + V S+  + + I     +  + +
Sbjct: 960  FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKI 1016

Query: 571  LRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF- 629
            LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+  
Sbjct: 1017 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1076

Query: 630  ------------------NFNDG-------------TPSANFDTFPAAIMTVFQILTGED 658
                               + DG                 +FD   AA+M +F + T E 
Sbjct: 1077 TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEG 1136

Query: 659  WNEVMYNGIRSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 713
            W E++Y  I S       +++     +I+FI+  +   + ++N+F+   +        +T
Sbjct: 1137 WPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VT 1188

Query: 714  KDEQEEEE------AFNQKHALQKAKEVSPM 738
              EQ E+E        NQ+  ++ A +  P+
Sbjct: 1189 FQEQGEQEYKNCELDKNQRQCVEYALKARPL 1219



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
            subunit [Homo sapiens]
          Length = 1977

 Score =  736 bits (1899), Expect = 0.0
 Identities = 374/822 (45%), Positives = 546/822 (66%), Gaps = 39/822 (4%)

Query: 1091 KTDGEASPLKEAEIREDEEEVEKKKQKKEKRETG-----KAMVPH---------SSMFIF 1136
            K + E +  + A++ E+EEE E++++++E+   G     + +VP          S+ F  
Sbjct: 795  KEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCL 854

Query: 1137 STTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGV 1196
            S TNP+R+ CH +++   F   IL+ I  SS++LAAEDP+  +S RN +L YFDY FT +
Sbjct: 855  SQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSI 914

Query: 1197 FTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKS 1256
            FT E+++KM   G  L  GS+ R  +N+LD +VV  +L++F + ++        I  +K 
Sbjct: 915  FTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSA-------ISVVKI 967

Query: 1257 LRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF 1316
            LRVLRVLRPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGKF+
Sbjct: 968  LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1027

Query: 1317 YCTDSSKDTEKECIGN---YVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEG 1373
             CTD +K T +EC G+   Y D + ++  V+ R W   +F++DN++ A++ LFTVST EG
Sbjct: 1028 TCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEG 1087

Query: 1374 WPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKM 1433
            WP +L  ++D   ED GP  + R+E+S+F++VY ++  FF +NIFV  +IITF+ QG++ 
Sbjct: 1088 WPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQE 1147

Query: 1434 MEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTV 1493
             + C L+KN+R C+++A+ A+PL RY+P+N H  QYRVW  V S +FEY +  +I LNTV
Sbjct: 1148 YQNCELDKNQRQCVEYALKAQPLRRYIPKNPH--QYRVWATVNSAAFEYLMFLLILLNTV 1205

Query: 1494 VLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGS 1553
             L M++Y     +  A+  LN+ FT +F++E VLK+IAF   +YF D WN FD + V+GS
Sbjct: 1206 ALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGS 1265

Query: 1554 ITEIILTD--------SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFK 1605
            I +I +T+            ++S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+
Sbjct: 1266 IVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQ 1325

Query: 1606 ALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAW 1665
            ALPYV LLIAM+FFIYA+IGMQ+FG + L + + INR+NNF++F  +++LLFR ATGEAW
Sbjct: 1326 ALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAW 1385

Query: 1666 QEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
            QEIML+ L    C+P++    G  E   CG++ A  YF+SF   C+FL++NLFVAVIMDN
Sbjct: 1386 QEIMLASLPGNRCDPESDF--GPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDN 1443

Query: 1726 FEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKV 1785
            F+YLTRD SILGPHHLDEF R+W+EYD  A GRI + ++  +L  + PPLG GK CP +V
Sbjct: 1444 FDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRV 1503

Query: 1786 AYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPH 1845
            A KRLV MNMP+  D TV F +TL AL+RT+L IK      + +Q + EL+     IW  
Sbjct: 1504 ACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTE---GNLEQANQELRIVIKKIWKR 1560

Query: 1846 LSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQR 1887
            + QK+LD ++P P   ++TVGK YA  +I DY+++ + +K++
Sbjct: 1561 MKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEK 1602



 Score =  585 bits (1507), Expect = e-166
 Identities = 343/757 (45%), Positives = 442/757 (58%), Gaps = 63/757 (8%)

Query: 67  RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEK 126
           R+LF     N +R+    +++W PF+ +IL TI ANC+ L +    PEDD    +  LE+
Sbjct: 70  RALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQ 129

Query: 127 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATA--------GT 178
            E  F+ IF  E  +KIVA G + H  +Y+RNGWN++DFI+V+ G+ +          G 
Sbjct: 130 VEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGD 189

Query: 179 HFNTH-----VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAIL 233
             +T       D++ LRA RVLRPL+LVSG+PSL IVL SIMKA+VPLL I LL+ F I+
Sbjct: 190 APHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVII 249

Query: 234 MFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPAGY-ECKD-WIGPND 287
           ++AIIGLE + G++H+ C+   S  +E  + P PC   G    C     EC+  W GPN 
Sbjct: 250 IYAIIGLELFLGRMHKTCYFLGSD-MEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNG 308

Query: 288 GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVL 347
           GIT FDN  FA+LTVFQC+TMEGWT VLY   DA+G    W+YF+ L+I GSFFVLNLVL
Sbjct: 309 GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL 368

Query: 348 GVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEV------------ML 395
           GVLSGEF+KERE+ + R  F K R +QQ+E +L GY  WI +AEE+             +
Sbjct: 369 GVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSM 428

Query: 396 AEENK----------------------NAGTSALEVLRRATIKRSRTEAMTRDSSDEHCV 433
           AEE +                      ++  S       A++  S T +MT    DE   
Sbjct: 429 AEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDED-- 486

Query: 434 DISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACV 493
           +         R   K  K       R   R+LR   R  VKS   YW VL LV LNT  +
Sbjct: 487 EEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTI 546

Query: 494 AIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIF 553
           A  HH QP WLT +  YA  + L LF +EM LK+YG+GP  Y  S FN FD  V  G I 
Sbjct: 547 ASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGIL 606

Query: 554 EVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLF 613
           E            GISVLR +RLLRIFK+T++WASL NLV SL++SMKSI SLL LLFLF
Sbjct: 607 ETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLF 666

Query: 614 IVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG 672
           I++F+LLGMQLFGG+FNF+   T  + FDTFP A++TVFQILTGEDWN VMY+GI + GG
Sbjct: 667 IIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGG 726

Query: 673 -VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQK 731
               GM   IYFI+L + GNY LLNVFLAIAVDNLA+    T  ++  E++ N+K   Q+
Sbjct: 727 PFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKS-NEKDLPQE 785

Query: 732 AKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRE 768
            + +     P +   E +  RR    M E       E
Sbjct: 786 NEGL----VPGVEKEEEEGARREGADMEEEEEEEEEE 818



 Score =  137 bits (345), Expect = 1e-31
 Identities = 156/718 (21%), Positives = 297/718 (41%), Gaps = 116/718 (16%)

Query: 75   DNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGI 134
            + ++R   ++ +      + +L  +  N + +A E H        +++  E      + +
Sbjct: 515  NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHH---GQPVWLTQIQEYANKVLLCL 571

Query: 135  FCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH--VDLRTLRAV 192
            F  E  +K+  LG      +Y+ + +N  D  VV  GIL T          + +  LR V
Sbjct: 572  FTVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCV 627

Query: 193  RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACF 252
            R+LR  K+     SL  ++ S++ +M  +  + LLLF  I++F+++G++ + GK +    
Sbjct: 628  RLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN---- 683

Query: 253  MNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWT 312
                     FD  H                       + FD    A+LTVFQ +T E W 
Sbjct: 684  ---------FDQTHTKR--------------------STFDTFPQALLTVFQILTGEDWN 714

Query: 313  TVLYNTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAF 367
             V+Y+   A G  +       +YFI L I G++ +LN+ L +     A         +  
Sbjct: 715  VVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGG 774

Query: 368  MKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDS 427
             K   ++ + +E  G    ++K EE    E  +  G    E            E    + 
Sbjct: 775  EK-SNEKDLPQENEGLVPGVEKEEE----EGARREGADMEE------------EEEEEEE 817

Query: 428  SDEHCVDISSVGTPLARASIKSAKV----DGVSYF-RHKERLLRISIRHMVKSQVFYWIV 482
             +E   +  + G  L +  +   KV    +G ++F   +   LR     ++   VF  ++
Sbjct: 818  EEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLI 877

Query: 483  LSLVALNTACVAIVHHNQPQ-WLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL----YFH 537
            L  + L++  +A     +   +  H+L Y ++ F  +F +E+ LKM   G  L    +  
Sbjct: 878  LVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCR 937

Query: 538  SSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLM 597
            S FN  D  + V S+  + + I     S  + +LR LR+LR  +       L+++V  + 
Sbjct: 938  SWFNMLD--LLVVSVSLISFGIHSSAISV-VKILRVLRVLRPLRAINRAKGLKHVVQCVF 994

Query: 598  SSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN-------------------FNDGTPSA 638
             ++++I +++ +  L   +FA +G+QLF G+F                    + DG  S 
Sbjct: 995  VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSR 1054

Query: 639  -------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWS-----A 680
                         NFD   +A+M +F + T E W  ++Y  I +       +++     +
Sbjct: 1055 PLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEIS 1114

Query: 681  IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM 738
            ++FIV  +   + ++N+F+   +       E  ++ Q  E   NQ+  ++ A +  P+
Sbjct: 1115 VFFIVYIIIIAFFMMNIFVGFVIITFRAQGE--QEYQNCELDKNQRQCVEYALKAQPL 1170



 Score =  136 bits (342), Expect = 3e-31
 Identities = 109/377 (28%), Positives = 181/377 (48%), Gaps = 44/377 (11%)

Query: 1113 KKKQKKEKRET---GKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIA 1169
            K++ +  K +T     A     ++F  +  NP+RR+C  IV  + F++ ILL I A+ +A
Sbjct: 49   KRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVA 108

Query: 1170 LAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDF 1227
            L    P   +     N  L   +YVF  +FT E V+K++  GL+L   +Y R+ WN+LDF
Sbjct: 109  LGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDF 168

Query: 1228 VVVVGALVAFALANALG-------TNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFD 1280
            ++VV  L +  L    G       T        +K+LR  RVLRPL+ +  +P L  V +
Sbjct: 169  IIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLN 228

Query: 1281 CVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKG---KFFYCTDSSKDTEKE-----CIGN 1332
             ++ +L  + +I ++    + I+A+I ++LF G   K  Y   S  + E++       G+
Sbjct: 229  SIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGS 288

Query: 1333 YVDHEKNKMEVKGREWKRHE---FHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDR 1389
                  N+ E +GR W        ++DN  +A+LT+F   T EGW  VL    D      
Sbjct: 289  GRACTLNQTECRGR-WPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQD------ 341

Query: 1390 GPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMMEECSL 1439
                +   E+   Y V  V+F  FFV N+ + ++   F ++       GD  K  E+  +
Sbjct: 342  ----AMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQM 397

Query: 1440 EKNERACIDFAISAKPL 1456
            E++ R  +D+   A+ L
Sbjct: 398  EEDLRGYLDWITQAEEL 414



 Score =  117 bits (294), Expect = 1e-25
 Identities = 83/315 (26%), Positives = 146/315 (46%), Gaps = 43/315 (13%)

Query: 426  DSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSL 485
            D +   CV+ +    PL R   K+          H+ R+        V S  F +++  L
Sbjct: 1154 DKNQRQCVEYALKAQPLRRYIPKNP---------HQYRVWAT-----VNSAAFEYLMFLL 1199

Query: 486  VALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDF 545
            + LNT  +A+ H+ Q     + +     +F GLF +EM LK+    P+ YF  ++N FD 
Sbjct: 1200 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDA 1259

Query: 546  GVTVGSIFEVVWAIFRPGTSFG----------ISVLRALRLLRIFKITKYWASLRNLVVS 595
             + VGSI ++       G   G          I+  R  R++R+ K+      +R L+ +
Sbjct: 1260 LIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWT 1319

Query: 596  LMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPAAIMTVFQ 652
             + S +++  +  L+ +   ++A++GMQ+F G+    DGT    + NF TFP A++ +F+
Sbjct: 1320 FIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINRNNNFQTFPQAVLLLFR 1378

Query: 653  ILTGEDWNEVMYNGI-------RSQGG-----VSSGMWSAIYFIVLTLFGNYTLLNVFLA 700
              TGE W E+M   +        S  G          ++  YFI   +   + ++N+F+A
Sbjct: 1379 CATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVA 1438

Query: 701  IAVDNLANAQELTKD 715
            + +DN      LT+D
Sbjct: 1439 VIMDNF---DYLTRD 1450



 Score =  106 bits (264), Expect = 3e-22
 Identities = 93/342 (27%), Positives = 158/342 (46%), Gaps = 30/342 (8%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + F   + N +RK    LI    F  +IL  II + + LA E   P    +  +  L   
Sbjct: 850  AFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAED--PIRAHSFRNHILGYF 907

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+   G   H+GS+ R+ +N++D +VV S  L + G H +    ++
Sbjct: 908  DYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVV-SVSLISFGIHSSAISVVK 966

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GK 
Sbjct: 967  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKF 1026

Query: 248  HRAC--FMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQC 305
            +       +     +G    +P G    P   E + W+  +     FDN+L A++ +F  
Sbjct: 1027 YTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRE-RLWVNSD---FNFDNVLSAMMALFTV 1082

Query: 306  ITMEGWTTVLYNTNDAL----GATWNW-----LYFIPLIIIGSFFVLNLVLGVLSGEFAK 356
             T EGW  +LY   DA     G  +N+     ++FI  III +FF++N+ +G +   F  
Sbjct: 1083 STFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRA 1142

Query: 357  ERERVENRRAFMKLRRQ------------QQIERELNGYRAW 386
            + E+        K +RQ            + I +  + YR W
Sbjct: 1143 QGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVW 1184



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 74/299 (24%), Positives = 142/299 (47%), Gaps = 18/299 (6%)

Query: 1427 QEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMA 1486
            + QGD+  EE +L    R C++  +  +   R    NR   + R    V S +  + ++ 
Sbjct: 480  ETQGDEDEEEGALASCTR-CLNKIMKTRVCRRLRRANR-VLRARCRRAVKSNACYWAVLL 537

Query: 1487 MIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD 1546
            ++ LNT+ +  +++  P       +Y N     +F++E +LK+   G   Y    +N FD
Sbjct: 538  LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD 597

Query: 1547 FITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1606
               V G I E  L +   +   G  +S L+  R  R+ K+ R   ++  L+ + + S K+
Sbjct: 598  CFVVCGGILETTLVEVGAMQPLG--ISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKS 655

Query: 1607 LPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQ 1666
            +  + LL+ +   I++++GMQ+FG     +++H  R + F +F  +L+ +F+  TGE W 
Sbjct: 656  IASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKR-STFDTFPQALLTVFQILTGEDWN 714

Query: 1667 EIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
             +M   +   G       P            L  +YF+      ++++LN+F+A+ +DN
Sbjct: 715  VVMYDGIMAYG------GPFFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 760



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 102/417 (24%), Positives = 174/417 (41%), Gaps = 92/417 (22%)

Query: 436 SSVGTPLARASIKSAKVDGVSYFRHKERLL---------RISIRHMVKSQVFYWIVLSLV 486
           S +GTP  R      K   V+  +   R L         R S   +V+ + F  ++L  +
Sbjct: 43  SGLGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTI 102

Query: 487 ALNTACVAI-----VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG----PRLYFH 537
             N  CVA+        +      H L   E++FL +F +E  LK+   G    P  Y  
Sbjct: 103 FAN--CVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIR 160

Query: 538 SSFNCFDFGVTVGSIFEVVW--AIFRPGTS---------FGISVLRALRLLRIFKITKYW 586
           + +N  DF + V  +F V+      RPG +         F +  LRA R+LR  ++    
Sbjct: 161 NGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGV 220

Query: 587 ASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN------------FNDG 634
            SL  ++ S+M ++  ++ +  L+   I+++A++G++LF GR +              D 
Sbjct: 221 PSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDP 280

Query: 635 TPSA---------------------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
           +P A                           NFD F  A++TVFQ +T E W +V+Y   
Sbjct: 281 SPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQ 340

Query: 668 RSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK----------DEQ 717
            + G      W  +YF+ L +FG++ +LN+ L +     +  +E  K           +Q
Sbjct: 341 DAMG--YELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQ 396

Query: 718 EEEEAFNQKHALQKAKEV---SPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRR 771
            EE+       + +A+E+    P +  N+ S+  + R  H      P+ + L  RRR
Sbjct: 397 MEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGH-----RPQLAELTNRRR 448



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 64/270 (23%), Positives = 123/270 (45%), Gaps = 74/270 (27%)

Query: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIIL------ 1559
            L+ +   F ++F++E VLK++A+G +     Y R+ WN+ DFI V+  +  ++L      
Sbjct: 127  LEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGR 186

Query: 1560 ------TDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1613
                  T  K     GF++  L+ FR  R ++L+    ++ I+L + +++   L ++ LL
Sbjct: 187  PGDAPHTGGK---PGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALL 243

Query: 1614 IAMLFFIYAIIGMQVF------------GNIKLDEESH------------INRH------ 1643
            +  +  IYAIIG+++F             +++ +E+              +N+       
Sbjct: 244  VLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRW 303

Query: 1644 -------NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGT 1696
                    NF +FF +++ +F+  T E W +++                      +  G 
Sbjct: 304  PGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWM------------------QDAMGY 345

Query: 1697 DLAYVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
            +L +VYFVS + F SF +LNL + V+   F
Sbjct: 346  ELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 375



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 66/286 (23%), Positives = 128/286 (44%), Gaps = 49/286 (17%)

Query: 1142 IRRACHYIVNLRYFEMCILLVIAASSIALAAE---DPVLTNSERNKVLRYFDYVFTGVFT 1198
            +R  C   V        +LL++  +++ +A+E    PV       ++  Y + V   +FT
Sbjct: 518  LRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLT----QIQEYANKVLLCLFT 573

Query: 1199 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
             EM++K+   G      +Y    +N  D  VV G ++   L   +G  +   I  ++ +R
Sbjct: 574  VEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILETTLVE-VGAMQPLGISVLRCVR 628

Query: 1259 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF-FY 1317
            +LR+ +  +    L  L A    ++ S+K++ ++L++  LF+ IF+++ +QLF GKF F 
Sbjct: 629  LLRIFKVTRHWASLSNLVA---SLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 685

Query: 1318 CTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQV 1377
             T + + T                             +D    ALLT+F + TGE W  V
Sbjct: 686  QTHTKRST-----------------------------FDTFPQALLTVFQILTGEDWNVV 716

Query: 1378 LQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALII 1423
            +   +        P     M + I++++ F+   +  +N+F+A+ +
Sbjct: 717  MYDGIMAYGGPFFPG----MLVCIYFIILFICGNYILLNVFLAIAV 758


>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 3 [Homo sapiens]
          Length = 2179

 Score =  734 bits (1895), Expect = 0.0
 Identities = 390/871 (44%), Positives = 545/871 (62%), Gaps = 73/871 (8%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKM 1205
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD VFT +FT E+ +KM
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKM 952

Query: 1206 IDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRP 1265
               G  L  GS+ R+ +NILD +VV  +L++F + ++        I  +K LRVLRVLRP
Sbjct: 953  TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-------INVVKILRVLRVLRP 1005

Query: 1266 LKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDT 1325
            L+ I R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGK + C+DSSK T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065

Query: 1326 EKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
            E EC GNY+ ++  +++   ++ R W+  +F +DN++ A++ LFTVST EGWP++L  S+
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKN 1442
            D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG++  + C L+KN
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185

Query: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
            +R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY +  +I LNT+ L M++Y  
Sbjct: 1186 QRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQ 1243

Query: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD- 1561
             C +++A+  LN+ FT +F++E +LK+IAF   +YF D WN FD + V+GSI +I +T+ 
Sbjct: 1244 SCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEV 1303

Query: 1562 ---------------------------------SKLVNTSGFNMSFLKLFRAARLIKLLR 1588
                                                   S  +++F +LFR  RL+KLL 
Sbjct: 1304 NPAEHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLS 1363

Query: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRS 1648
            +G  IR LLWTF++SF+ALPYV LLI MLFFIYA+IGMQVFG I L++ + INR+NNF++
Sbjct: 1364 RGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQT 1423

Query: 1649 FFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENER-CGTDLAYVYFVSFI 1707
            F  +++LLFR ATGEAWQ+IML+C+  K C P+ + PS   E E  CG+  A  YF+SF 
Sbjct: 1424 FPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE-SEPSNSTEGETPCGSSFAVFYFISFY 1482

Query: 1708 FFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEM 1767
              C+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R+WAEYD  A GRI + ++  +
Sbjct: 1483 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1542

Query: 1768 LTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKG--- 1824
            L  + PPLG GK CP +VA KRLV MNMP+  D TV F +TL AL+RTAL IK  +G   
Sbjct: 1543 LRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSP 1602

Query: 1825 -------------GADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAA 1871
                           + +Q + EL+     IW   S K+LD +VP     ++TVGK YA 
Sbjct: 1603 SEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYAT 1662

Query: 1872 MMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
             +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1663 FLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1693



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  186 bits (473), Expect = 2e-46
 Identities = 172/720 (23%), Positives = 305/720 (42%), Gaps = 163/720 (22%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   P    +  +  L   
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED--PVQHTSFRNHILFYF 936

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV S  L + G   +    ++
Sbjct: 937  DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVV-SVSLISFGIQSSAINVVK 995

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GKL
Sbjct: 996  ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055

Query: 248  HRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILF 297
            +            C  N     +G +  HP          + + W    +    FDN+L 
Sbjct: 1056 YTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQPRSW---ENSKFDFDNVLA 1103

Query: 298  AVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLG 348
            A++ +F   T EGW  +LY + D+     G  +N+     ++FI  III +FF++N+ +G
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163

Query: 349  VLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALE 408
                              F+ +  Q+Q E+E                             
Sbjct: 1164 ------------------FVIVTFQEQGEQEYKNCEL----------------------- 1182

Query: 409  VLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRIS 468
                             D +   CV+ +    PL R   K+         +H+ +     
Sbjct: 1183 -----------------DKNQRQCVEYALKARPLRRYIPKN---------QHQYK----- 1211

Query: 469  IRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMY 528
            + ++V S  F +++  L+ LNT C+A+ H+ Q       +     LF GLF +EM LK+ 
Sbjct: 1212 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1271

Query: 529  GMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPG------------------------- 563
               P+ YF  ++N FD  + VGSI ++      P                          
Sbjct: 1272 AFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPP 1331

Query: 564  -----------TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFL 612
                       +   I+  R  R++R+ K+      +R L+ + + S +++  +  L+ +
Sbjct: 1332 VADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1391

Query: 613  FIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPAAIMTVFQILTGEDWNEVMYNGI-- 667
               ++A++GMQ+F G+   ND T    + NF TFP A++ +F+  TGE W ++M   +  
Sbjct: 1392 LFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPG 1450

Query: 668  -----------RSQGGVSSG-MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
                        ++G    G  ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1451 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1507



 Score =  135 bits (340), Expect = 5e-31
 Identities = 154/731 (21%), Positives = 303/731 (41%), Gaps = 140/731 (19%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRL 534
            F  ++L  + L++  +A    V H    +  H+L+Y + +F  +F +E++LKM   G  L
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKMTAYGAFL 959

Query: 535  ----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLR 590
                +  + FN  D  + V S+  + + I     +  + +LR LR+LR  +       L+
Sbjct: 960  HKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKILRVLRVLRPLRAINRAKGLK 1016

Query: 591  NLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NF 631
            ++V  +  ++++I +++ +  L   +FA +G+QLF G+                     +
Sbjct: 1017 HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITY 1076

Query: 632  NDG-------------TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMW 678
             DG                 +FD   AA+M +F + T E W E++Y  I S       ++
Sbjct: 1077 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIY 1136

Query: 679  S-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE------AFNQKH 727
            +     +I+FI+  +   + ++N+F+   +        +T  EQ E+E        NQ+ 
Sbjct: 1137 NYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VTFQEQGEQEYKNCELDKNQRQ 1188

Query: 728  ALQKAKEVSPM 738
             ++ A +  P+
Sbjct: 1189 CVEYALKARPL 1199



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 2 [Homo sapiens]
          Length = 2186

 Score =  733 bits (1892), Expect = 0.0
 Identities = 392/881 (44%), Positives = 548/881 (62%), Gaps = 86/881 (9%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD--------------- 1190
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD               
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKI 952

Query: 1191 -----YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGT 1245
                 YVFT +FT E+++KM   G  L  GS+ R+ +NILD +VV  +L++F + ++   
Sbjct: 953  LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-- 1010

Query: 1246 NKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAV 1305
                 I  +K LRVLRVLRPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA 
Sbjct: 1011 -----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065

Query: 1306 IAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWAL 1362
            I VQLFKGK + C+DSSK TE EC GNY+ ++  +++   ++ R W+  +F +DN++ A+
Sbjct: 1066 IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAM 1125

Query: 1363 LTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALI 1422
            + LFTVST EGWP++L  S+D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +
Sbjct: 1126 MALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV 1185

Query: 1423 IITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEY 1482
            I+TFQEQG++  + C L+KN+R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY
Sbjct: 1186 IVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEY 1243

Query: 1483 TIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTW 1542
             +  +I LNT+ L M++Y   C +++A+  LN+ FT +F++E +LK+IAF    YF D W
Sbjct: 1244 LMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPW 1303

Query: 1543 NIFDFITVIGSITEIILTDSK--------------------------------------- 1563
            N+FDF+ VIGSI ++IL+++                                        
Sbjct: 1304 NVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSM 1363

Query: 1564 -LVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1622
                 S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA
Sbjct: 1364 NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1423

Query: 1623 IIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDT 1682
            +IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P++
Sbjct: 1424 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPES 1483

Query: 1683 TAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHL 1741
              PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHHL
Sbjct: 1484 E-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL 1542

Query: 1742 DEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDM 1801
            DEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D 
Sbjct: 1543 DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDG 1602

Query: 1802 TVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKAS 1861
            TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K+LD +VP     
Sbjct: 1603 TVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDD 1659

Query: 1862 DLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1660 EVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1700



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  181 bits (458), Expect = 9e-45
 Identities = 175/744 (23%), Positives = 308/744 (41%), Gaps = 185/744 (24%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALE---QHLPEDDKTPMS--- 121
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   QH    +        
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938

Query: 122  ------------RRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL 169
                        + L   +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV 
Sbjct: 939  VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV- 997

Query: 170  SGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLF 229
            S  L + G   +    ++ LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++  
Sbjct: 998  SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057

Query: 230  FAILMFAIIGLEFYSGKLHRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYEC 279
                MFA IG++ + GKL+            C  N     +G +  HP          + 
Sbjct: 1058 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQP 1108

Query: 280  KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LY 330
            + W    +    FDN+L A++ +F   T EGW  +LY + D+     G  +N+     ++
Sbjct: 1109 RSW---ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1165

Query: 331  FIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKA 390
            FI  III +FF++N+ +G                  F+ +  Q+Q E+E           
Sbjct: 1166 FIIYIIIIAFFMMNIFVG------------------FVIVTFQEQGEQEYKNCEL----- 1202

Query: 391  EEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSA 450
                                               D +   CV+ +    PL R   K+ 
Sbjct: 1203 -----------------------------------DKNQRQCVEYALKARPLRRYIPKN- 1226

Query: 451  KVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYY 510
                    +H+ +     + ++V S  F +++  L+ LNT C+A+ H+ Q       +  
Sbjct: 1227 --------QHQYK-----VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNI 1273

Query: 511  AEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVV-----------WAI 559
               LF GLF +EM LK+    P+ YF   +N FDF + +GSI +V+           W  
Sbjct: 1274 LNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNT 1333

Query: 560  F-------------------------------RPGTSFGISVLRALRLLRIFKITKYWAS 588
            F                                  +   I+  R  R++R+ K+      
Sbjct: 1334 FDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEG 1393

Query: 589  LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPA 645
            +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND T    + NF TFP 
Sbjct: 1394 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQ 1452

Query: 646  AIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-MWSAIYFIVLTLFGN 691
            A++ +F+  TGE W ++M   +              ++G    G  ++  YFI   +   
Sbjct: 1453 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1512

Query: 692  YTLLNVFLAIAVDNLANAQELTKD 715
            + ++N+F+A+ +DN      LT+D
Sbjct: 1513 FLIINLFVAVIMDNF---DYLTRD 1533



 Score =  127 bits (319), Expect = 1e-28
 Identities = 156/751 (20%), Positives = 304/751 (40%), Gaps = 160/751 (21%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYY--------------------AEFL 514
            F  ++L  + L++  +A    V H    +  H+L+Y                    A+++
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKILGNADYV 959

Query: 515  FLGLFLLEMSLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISV 570
            F  +F LE+ LKM   G  L    +  + FN  D  + V S+  + + I     +  + +
Sbjct: 960  FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKI 1016

Query: 571  LRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF- 629
            LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+  
Sbjct: 1017 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1076

Query: 630  ------------------NFNDG-------------TPSANFDTFPAAIMTVFQILTGED 658
                               + DG                 +FD   AA+M +F + T E 
Sbjct: 1077 TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEG 1136

Query: 659  WNEVMYNGIRSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 713
            W E++Y  I S       +++     +I+FI+  +   + ++N+F+   +        +T
Sbjct: 1137 WPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VT 1188

Query: 714  KDEQEEEE------AFNQKHALQKAKEVSPM 738
              EQ E+E        NQ+  ++ A +  P+
Sbjct: 1189 FQEQGEQEYKNCELDKNQRQCVEYALKARPL 1219



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 1 [Homo sapiens]
          Length = 2221

 Score =  733 bits (1892), Expect = 0.0
 Identities = 392/881 (44%), Positives = 548/881 (62%), Gaps = 86/881 (9%)

Query: 1093 DGEASPLKEAEIREDEEEVEKKKQKKEK-------RETGKAMVPHSSMFIFSTTNPIRRA 1145
            D    P  E    EDEEE E     + +       +E    M   S+ FIFS+ N  R  
Sbjct: 833  DKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQ 892

Query: 1146 CHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD--------------- 1190
            CH IVN   F   IL  I  SSI+LAAEDPV   S RN +L YFD               
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKI 952

Query: 1191 -----YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGT 1245
                 YVFT +FT E+++KM   G  L  GS+ R+ +NILD +VV  +L++F + ++   
Sbjct: 953  LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA-- 1010

Query: 1246 NKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAV 1305
                 I  +K LRVLRVLRPL+ I R   LK V  CV  +++ + NI+IV  L  F+FA 
Sbjct: 1011 -----INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065

Query: 1306 IAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWAL 1362
            I VQLFKGK + C+DSSK TE EC GNY+ ++  +++   ++ R W+  +F +DN++ A+
Sbjct: 1066 IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAM 1125

Query: 1363 LTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALI 1422
            + LFTVST EGWP++L  S+D   ED+GP  + R+E+SIF+++Y ++  FF +NIFV  +
Sbjct: 1126 MALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV 1185

Query: 1423 IITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEY 1482
            I+TFQEQG++  + C L+KN+R C+++A+ A+PL RY+P+N+H  QY+VW+ V S  FEY
Sbjct: 1186 IVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEY 1243

Query: 1483 TIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTW 1542
             +  +I LNT+ L M++Y   C +++A+  LN+ FT +F++E +LK+IAF    YF D W
Sbjct: 1244 LMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPW 1303

Query: 1543 NIFDFITVIGSITEIILTDSK--------------------------------------- 1563
            N+FDF+ VIGSI ++IL+++                                        
Sbjct: 1304 NVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSM 1363

Query: 1564 -LVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1622
                 S  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLI MLFFIYA
Sbjct: 1364 NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1423

Query: 1623 IIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDT 1682
            +IGMQVFG I L++ + INR+NNF++F  +++LLFR ATGEAWQ+IML+C+  K C P++
Sbjct: 1424 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPES 1483

Query: 1683 TAPSGQNENER-CGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHL 1741
              PS   E E  CG+  A  YF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHHL
Sbjct: 1484 E-PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL 1542

Query: 1742 DEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDM 1801
            DEF R+WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D 
Sbjct: 1543 DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDG 1602

Query: 1802 TVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKAS 1861
            TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K+LD +VP     
Sbjct: 1603 TVMFNATLFALVRTALRIKTE---GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDD 1659

Query: 1862 DLTVGKIYAAMMIMDYYKQSKVKKQRQQL--EEQKNAPMFQ 1900
            ++TVGK YA  +I +Y+++ K +K++  +    Q+NA   Q
Sbjct: 1660 EVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ 1700



 Score =  630 bits (1626), Expect = e-180
 Identities = 359/754 (47%), Positives = 468/754 (62%), Gaps = 35/754 (4%)

Query: 25  RQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNR---SLFIFGEDNIVRKY 81
           RQ   + ++G A     +  QR R    Y   P +Q   T  R   +L      N +R+ 
Sbjct: 60  RQAKLMGSAGNATISTVSSTQRKRQQ--YGK-PKKQGSTTATRPPRALLCLTLKNPIRRA 116

Query: 82  AKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGI 141
              +++W PFE +IL TI ANC+ LA+    PEDD    +  LE+ E  F+ IF  EA +
Sbjct: 117 CISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFL 176

Query: 142 KIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL------ATAGTHFNT------HVDLRTL 189
           K++A G +FH  +YLRNGWN++DFI+V+ G+       AT     N         D++ L
Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236

Query: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
           RA RVLRPL+LVSG+PSLQ+VL SI+KAMVPLL I LL+ F I+++AIIGLE + GK+H+
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296

Query: 250 ACFMNNSGILE--GFDPPHPCGVQG-----CPAGYECKD-WIGPNDGITQFDNILFAVLT 301
            C+ N  GI +    D P PC ++      C  G  CK  W GP  GIT FDN  FA+LT
Sbjct: 297 TCY-NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 302 VFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERV 361
           VFQCITMEGWT VLY  NDA+G  W W+YF+ LIIIGSFFVLNLVLGVLSGEF+KERE+ 
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKA 415

Query: 362 ENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTE 421
           + R  F KLR +QQ+E +L GY  WI +AE++    EN++ G    E  R  ++  S TE
Sbjct: 416 KARGDFQKLREKQQLEEDLKGYLDWITQAEDI--DPENEDEGMDE-EKPRNMSMPTSETE 472

Query: 422 AMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWI 481
           ++  ++     ++  + G  LA    KS       Y+R   R  R   R  VKS VFYW+
Sbjct: 473 SVNTENVAGGDIEGENCGARLAHRISKSKFS---RYWRRWNRFCRRKCRAAVKSNVFYWL 529

Query: 482 VLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFN 541
           V+ LV LNT  +A  H+NQP WLT +   A    L LF  EM LKMY +G + YF S FN
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 542 CFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMK 601
            FD  V  G I E +    +  +  GISVLR +RLLRIFKIT+YW SL NLV SL++S++
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649

Query: 602 SIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWN 660
           SI SLL LLFLFI++F+LLGMQLFGG+FNF++  T  + FD FP +++TVFQILTGEDWN
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709

Query: 661 EVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
            VMY+GI + GG S  GM   IYFI+L + GNY LLNVFLAIAVDNLA+A+ LT  ++EE
Sbjct: 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769

Query: 720 EEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRR 753
           EE   +K   + A           P++   +  +
Sbjct: 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEK 803



 Score =  220 bits (561), Expect = 1e-56
 Identities = 185/707 (26%), Positives = 329/707 (46%), Gaps = 124/707 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+ +  A  P  ++   +  NPIRRAC  IV  + FE+ ILL I A+ +
Sbjct: 80   QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCV 139

Query: 1169 ALAA------EDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLW 1222
            ALA       +D   TNS   +V    +Y+F  +FT E  +K+I  GL+    +Y R+ W
Sbjct: 140  ALAIYIPFPEDDSNATNSNLERV----EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGW 195

Query: 1223 NILDFVVVVGALVAFAL--------ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
            N+LDF++VV  L +  L        ANALG  KG     +K+LR  RVLRPL+ +  +P 
Sbjct: 196  NLLDFIIVVVGLFSAILEQATKADGANALG-GKGAGF-DVKALRAFRVLRPLRLVSGVPS 253

Query: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDS-------SKDTE 1326
            L+ V + ++ ++  + +I ++    + I+A+I ++LF GK    C +        ++D  
Sbjct: 254  LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313

Query: 1327 KEC---IGNYVDHEKNKMEVKGREWKRHEF-HYDNIIWALLTLFTVSTGEGWPQVLQHSV 1382
              C    G+    +   +   G +  +H   ++DN  +A+LT+F   T EGW  VL    
Sbjct: 314  SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 373

Query: 1383 DVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KM 1433
            D    D            I++V   ++  FF +N+ + ++   F ++       GD  K+
Sbjct: 374  DAVGRD---------WPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 424

Query: 1434 MEECSLEKNERACIDFAISA---------------KPLTRYMP----------------- 1461
             E+  LE++ +  +D+   A               KP    MP                 
Sbjct: 425  REKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDI 484

Query: 1462 --------------QNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMK 1498
                          +++ +  +R W+          V S  F + ++ ++ LNT+ +  +
Sbjct: 485  EGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE 544

Query: 1499 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1558
            +Y+ P          N A   +F+ E +LK+ + G   YF   +N FD   V G I E I
Sbjct: 545  HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604

Query: 1559 LTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1618
            L ++K+++  G  +S L+  R  R+ K+ R   ++  L+ + + S +++  + LL+ +  
Sbjct: 605  LVETKIMSPLG--ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFI 662

Query: 1619 FIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGC 1678
             I++++GMQ+FG  K + +    R + F +F  SL+ +F+  TGE W  +M   +   G 
Sbjct: 663  IIFSLLGMQLFGG-KFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG- 720

Query: 1679 EPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                  PS           L  +YF+      ++++LN+F+A+ +DN
Sbjct: 721  -----GPSFPGM-------LVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score =  181 bits (458), Expect = 9e-45
 Identities = 175/744 (23%), Positives = 308/744 (41%), Gaps = 185/744 (24%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALE---QHLPEDDKTPMS--- 121
            + FIF  +N  R    ++++   F  +IL  I+ + I LA E   QH    +        
Sbjct: 879  AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDI 938

Query: 122  ------------RRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL 169
                        + L   +  F  IF  E  +K+ A G   HKGS+ RN +N++D +VV 
Sbjct: 939  VFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV- 997

Query: 170  SGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLF 229
            S  L + G   +    ++ LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++  
Sbjct: 998  SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057

Query: 230  FAILMFAIIGLEFYSGKLHRA----------CFMNNSGILEGFDPPHPCGVQGCPAGYEC 279
                MFA IG++ + GKL+            C  N     +G +  HP          + 
Sbjct: 1058 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDG-EVDHPI--------IQP 1108

Query: 280  KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LY 330
            + W    +    FDN+L A++ +F   T EGW  +LY + D+     G  +N+     ++
Sbjct: 1109 RSW---ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1165

Query: 331  FIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKA 390
            FI  III +FF++N+ +G                  F+ +  Q+Q E+E           
Sbjct: 1166 FIIYIIIIAFFMMNIFVG------------------FVIVTFQEQGEQEYKNCEL----- 1202

Query: 391  EEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSA 450
                                               D +   CV+ +    PL R   K+ 
Sbjct: 1203 -----------------------------------DKNQRQCVEYALKARPLRRYIPKN- 1226

Query: 451  KVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYY 510
                    +H+ +     + ++V S  F +++  L+ LNT C+A+ H+ Q       +  
Sbjct: 1227 --------QHQYK-----VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNI 1273

Query: 511  AEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVV-----------WAI 559
               LF GLF +EM LK+    P+ YF   +N FDF + +GSI +V+           W  
Sbjct: 1274 LNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNT 1333

Query: 560  F-------------------------------RPGTSFGISVLRALRLLRIFKITKYWAS 588
            F                                  +   I+  R  R++R+ K+      
Sbjct: 1334 FDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEG 1393

Query: 589  LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTP---SANFDTFPA 645
            +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+   ND T    + NF TFP 
Sbjct: 1394 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALNDTTEINRNNNFQTFPQ 1452

Query: 646  AIMTVFQILTGEDWNEVMYNGI-------------RSQGGVSSG-MWSAIYFIVLTLFGN 691
            A++ +F+  TGE W ++M   +              ++G    G  ++  YFI   +   
Sbjct: 1453 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1512

Query: 692  YTLLNVFLAIAVDNLANAQELTKD 715
            + ++N+F+A+ +DN      LT+D
Sbjct: 1513 FLIINLFVAVIMDNF---DYLTRD 1533



 Score =  127 bits (319), Expect = 1e-28
 Identities = 156/751 (20%), Positives = 304/751 (40%), Gaps = 160/751 (21%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E +   +  T +     K     + +F  E  +K+ +LG   
Sbjct: 526  FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKA---LLALFTAEMLLKMYSLGL-- 580

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT--AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 208
               +Y  + +N  D  VV  GIL T    T   + + +  LR VR+LR  K+     SL 
Sbjct: 581  --QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++F+++G++ + GK +             FD     
Sbjct: 639  NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------------FDEMQTR 685

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT--- 325
                                 + FDN   ++LTVFQ +T E W +V+Y+   A G     
Sbjct: 686  R--------------------STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP 725

Query: 326  --WNWLYFIPLIIIGSFFVLNLVLGVLSGEFA-------------KERERVENRRAFMKL 370
                 +YFI L I G++ +LN+ L +     A             +E+ER +  R     
Sbjct: 726  GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 785

Query: 371  RRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT------ 424
            ++Q+ +E+   G      K E++ L     +  +     +    ++ +  E  +      
Sbjct: 786  KKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPE 841

Query: 425  ---RDSSDEHCVDISSVGTPLARASIKSAKVD----GVSYFRHKERLLRISIRHMVKSQV 477
                +  +E  + +     PL+   +K   V        +        R+    +V   +
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 478  FYWIVLSLVALNTACVAI---VHHNQPQWLTHLLYY--------------------AEFL 514
            F  ++L  + L++  +A    V H    +  H+L+Y                    A+++
Sbjct: 902  FTNLILFFILLSSISLAAEDPVQHTS--FRNHILFYFDIVFTTIFTIEIALKILGNADYV 959

Query: 515  FLGLFLLEMSLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISV 570
            F  +F LE+ LKM   G  L    +  + FN  D  + V S+  + + I     +  + +
Sbjct: 960  FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD--LLVVSVSLISFGIQSSAINV-VKI 1016

Query: 571  LRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF- 629
            LR LR+LR  +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+  
Sbjct: 1017 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1076

Query: 630  ------------------NFNDG-------------TPSANFDTFPAAIMTVFQILTGED 658
                               + DG                 +FD   AA+M +F + T E 
Sbjct: 1077 TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEG 1136

Query: 659  WNEVMYNGIRSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 713
            W E++Y  I S       +++     +I+FI+  +   + ++N+F+   +        +T
Sbjct: 1137 WPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI--------VT 1188

Query: 714  KDEQEEEE------AFNQKHALQKAKEVSPM 738
              EQ E+E        NQ+  ++ A +  P+
Sbjct: 1189 FQEQGEQEYKNCELDKNQRQCVEYALKARPL 1219



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 72/302 (23%), Positives = 131/302 (43%), Gaps = 74/302 (24%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAPCTYELA----LKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     A    L+ +   F ++F++E  LKVIA+G L
Sbjct: 126  FEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLL 184

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTS--------GFNMSFLKLFRAARL 1583
                 Y R+ WN+ DFI V+  +   IL  +   + +        GF++  L+ FR  R 
Sbjct: 185  FHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRP 244

Query: 1584 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-------------- 1629
            ++L+    +++++L + +++   L ++ LL+  +  IYAIIG+++F              
Sbjct: 245  LRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI 304

Query: 1630 GNIKLDE-------ESHINRH------------------NNFRSFFGSLMLLFRSATGEA 1664
             ++  ++       E+   R                    NF +F  +++ +F+  T E 
Sbjct: 305  ADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 364

Query: 1665 WQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD 1724
            W +++                     N+  G D  ++YFV+ I   SF +LNL + V+  
Sbjct: 365  WTDVLYWV------------------NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG 406

Query: 1725 NF 1726
             F
Sbjct: 407  EF 408


>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform c [Homo sapiens]
          Length = 2137

 Score =  733 bits (1891), Expect = 0.0
 Identities = 378/801 (47%), Positives = 536/801 (66%), Gaps = 25/801 (3%)

Query: 1098 PLKEAEIREDEEEVEKKKQKKEKRETGKAM------VPH-SSMFIFSTTNPIRRACHYIV 1150
            P+ E E  E+E+E E     + +R +   M      +P  S+ FI S TNPIR  CH ++
Sbjct: 824  PVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLI 883

Query: 1151 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL 1210
            N   F   IL+ I  SS ALAAEDP+ ++S RN +L YFDY FT +FT E+++KM   G 
Sbjct: 884  NHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGA 943

Query: 1211 ILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1270
             L  G++ R+ +N+LD +VV  +LV+F + ++        I  +K LRVLRVLRPL+ I 
Sbjct: 944  FLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-------ISVVKILRVLRVLRPLRAIN 996

Query: 1271 RLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI 1330
            R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGKF+ CTD +K   +EC 
Sbjct: 997  RAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECR 1056

Query: 1331 GNYV---DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
            G ++   D + +   V+ R W+  +F++DN++ A++ LFTVST EGWP +L  ++D   E
Sbjct: 1057 GLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGE 1116

Query: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACI 1447
            + GP  ++R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG+K  + C L+KN+R C+
Sbjct: 1117 NIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCV 1176

Query: 1448 DFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYE 1507
            ++A+ A+PL RY+P+N   +QY+ W+ V S  FEY +  +I LNT+ L M++Y     + 
Sbjct: 1177 EYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1234

Query: 1508 LALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNT 1567
             A+  LN+ FT VF++E VLKVIAF    YF D WN FD + VIGSI ++ L+++     
Sbjct: 1235 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEE 1294

Query: 1568 SG-FNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1626
            S   +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV LLIAMLFFIYA+IGM
Sbjct: 1295 SNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGM 1354

Query: 1627 QVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPS 1686
            Q+FG + + + + INR+NNF++F  +++LLFR ATGEAWQEIML+CL  K C+P++    
Sbjct: 1355 QMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNP 1414

Query: 1687 GQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVR 1746
            G  E   CG++ A VYF+SF   C+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF R
Sbjct: 1415 G--EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKR 1472

Query: 1747 VWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFT 1806
            +W+EYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MNMP+  D TV F 
Sbjct: 1473 IWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFN 1532

Query: 1807 STLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVG 1866
            +TL AL+RTAL IK      + +Q + EL+     IW   S K+LD +VP     ++TVG
Sbjct: 1533 ATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVG 1589

Query: 1867 KIYAAMMIMDYYKQSKVKKQR 1887
            K YA  +I DY+++ K +K++
Sbjct: 1590 KFYATFLIQDYFRKFKKRKEQ 1610



 Score =  618 bits (1593), Expect = e-176
 Identities = 362/775 (46%), Positives = 478/775 (61%), Gaps = 51/775 (6%)

Query: 12  PGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPV-------RQNCFT 64
           P SG+G + Q  + + T +  S QAA     +A+ A+TM+   P PV       RQ    
Sbjct: 33  PLSGEGPTSQPNSSKQTVL--SWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK 90

Query: 65  VN-----------RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLP 113
                        R+LF    +N +R+    +++W PF+  IL  I ANC+ LA+    P
Sbjct: 91  SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFP 150

Query: 114 EDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL 173
           EDD    +  LEK E  F+ IF  E  +KI+A G + H  +Y+RNGWN++DF++V+ G+ 
Sbjct: 151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF 210

Query: 174 A------TAGTHFNTH-------VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVP 220
           +      T  T    H        D++ LRA RVLRPL+LVSG+PSLQ+VL SI+KAMVP
Sbjct: 211 SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 270

Query: 221 LLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPA- 275
           LL I LL+ F I+++AIIGLE + GK+H+ CF  +S I+   DP  PC   G    C A 
Sbjct: 271 LLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPA-PCAFSGNGRQCTAN 329

Query: 276 GYECKD-WIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
           G EC+  W+GPN GIT FDN  FA+LTVFQCITMEGWT VLY  NDA+G    W+YF+ L
Sbjct: 330 GTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSL 389

Query: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
           +I GSFFVLNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +L GY  WI +AE++ 
Sbjct: 390 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI- 448

Query: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDG 454
              EN+  G    E  R  ++  S TE++  ++      +    G+ L +A  KS     
Sbjct: 449 -DPENEEEGGE--EGKRNTSMPTSETESVNTENVSGEGENRGCCGS-LCQAISKSKLS-- 502

Query: 455 VSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFL 514
              +R   R  R   R  VKS  FYW+V+ LV LNT  ++  H+NQP WLT +   A  +
Sbjct: 503 -RRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV 561

Query: 515 FLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRAL 574
            L LF  EM +KMY +G + YF S FN FD  V  G I E +       +  GISV R +
Sbjct: 562 LLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621

Query: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFND- 633
           RLLRIFK+T++W SL NLV SL++SMKSI SLL LLFLFI++F+LLGMQLFGG+FNF++ 
Sbjct: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET 681

Query: 634 GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG-VSSGMWSAIYFIVLTLFGNY 692
            T  + FD FP A++TVFQILTGEDWN VMY+GI + GG  SSGM   IYFI+L + GNY
Sbjct: 682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 741

Query: 693 TLLNVFLAIAVDNLANAQEL-TKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSI 746
            LLNVFLAIAVDNLA+A+ L T  ++E EE   +K A +++ E    + P +  I
Sbjct: 742 ILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQI 796



 Score =  213 bits (541), Expect = 2e-54
 Identities = 173/704 (24%), Positives = 322/704 (45%), Gaps = 121/704 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+       P  ++F  S  NPIRRAC  IV  + F++ ILL I A+ +
Sbjct: 82   QRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCV 141

Query: 1169 ALAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD 1226
            ALA   P   +     N  L   +Y F  +FT E  +K+I  GL+L   +Y R+ WN+LD
Sbjct: 142  ALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD 201

Query: 1227 FVVVVGALVAFALANALGTNKGRDIKT-------IKSLRVLRVLRPLKTIKRLPKLKAVF 1279
            FV+V+  L +  L       +G +  +       +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 202  FVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVL 261

Query: 1280 DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTE-------- 1326
            + ++ ++  + +I ++    + I+A+I ++LF GK     FF  +D   + +        
Sbjct: 262  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSG 321

Query: 1327 --KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDV 1384
              ++C  N  +     +   G        ++DN  +A+LT+F   T EGW  VL    D 
Sbjct: 322  NGRQCTANGTECRSGWVGPNG-----GITNFDNFAFAMLTVFQCITMEGWTDVLYWMND- 375

Query: 1385 TEEDRGPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMM 1434
                     +   E+   Y V  V+F  FFV N+ + ++   F ++       GD  K+ 
Sbjct: 376  ---------AMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLR 426

Query: 1435 EECSLEKNERACIDFAISAK---------------------------------------- 1454
            E+  LE++ +  +D+   A+                                        
Sbjct: 427  EKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR 486

Query: 1455 ----PLTRYMPQNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMKYYS 1501
                 L + + +++ + ++R W+          V S +F + ++ ++ LNT+ +  ++Y+
Sbjct: 487  GCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYN 546

Query: 1502 APCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD 1561
             P          N     +F+ E ++K+ + G   YF   +N FD   V G ITE IL +
Sbjct: 547  QPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVE 606

Query: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
             ++++  G  +S  +  R  R+ K+ R   ++  L+ + + S K++  + LL+ +   I+
Sbjct: 607  LEIMSPLG--ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIF 664

Query: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
            +++GMQ+FG  K + +    + + F +F  +L+ +F+  TGE W  +M   +   G    
Sbjct: 665  SLLGMQLFGG-KFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG---- 719

Query: 1682 TTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
               PS           +  +YF+      ++++LN+F+A+ +DN
Sbjct: 720  --GPSSSGM-------IVCIYFIILFICGNYILLNVFLAIAVDN 754



 Score =  191 bits (485), Expect = 7e-48
 Identities = 168/684 (24%), Positives = 298/684 (43%), Gaps = 126/684 (18%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FI  + N +R    KLI+   F  +IL  I+ +   LA E   P    +  +  L   
Sbjct: 865  AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGI-LATAGTHFNTHVDL 186
            +  F  IF  E  +K+   G   HKG++ RN +N++D +VV  G+ L + G   +    +
Sbjct: 923  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 980

Query: 187  RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
            + LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GK
Sbjct: 981  KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1040

Query: 247  LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGP-------NDGITQFDNILFAV 299
             +R      S        P  C  +G    Y+  D   P        +    FDN+L A+
Sbjct: 1041 FYRCTDEAKSN-------PEEC--RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAM 1091

Query: 300  LTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLGVL 350
            + +F   T EGW  +LY   D+    +G  +N      ++FI  III +FF++N+ +G  
Sbjct: 1092 MALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG-- 1149

Query: 351  SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVL 410
                            F+ +  Q+Q E+E                               
Sbjct: 1150 ----------------FVIVTFQEQGEKEYKNCEL------------------------- 1168

Query: 411  RRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIR 470
                           D +   CV+ +    PL R   K+        +++K         
Sbjct: 1169 ---------------DKNQRQCVEYALKARPLRRYIPKNP-------YQYK-------FW 1199

Query: 471  HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
            ++V S  F +++  L+ LNT C+A+ H+ Q +     +     +F G+F +EM LK+   
Sbjct: 1200 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259

Query: 531  GPRLYFHSSFNCFDFGVTVGSIFEVVWA---IFRPGTSFGISVLRALRLLRIFKITKYWA 587
             P+ YF  ++N FD  + +GSI +V  +            I+  R  R++R+ K+     
Sbjct: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGE 1319

Query: 588  SLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG--GRFNFNDGTPSANFDTFPA 645
             +R L+ + + S +++  +  L+ +   ++A++GMQ+FG     + N    + NF TFP 
Sbjct: 1320 GIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQ 1379

Query: 646  AIMTVFQILTGEDWNEVM--------------YNGIRSQGGVSSGMWSAIYFIVLTLFGN 691
            A++ +F+  TGE W E+M              YN    +       ++ +YFI   +   
Sbjct: 1380 AVLLLFRCATGEAWQEIMLACLPGKLCDPESDYN--PGEEYTCGSNFAIVYFISFYMLCA 1437

Query: 692  YTLLNVFLAIAVDNLANAQELTKD 715
            + ++N+F+A+ +DN      LT+D
Sbjct: 1438 FLIINLFVAVIMDNF---DYLTRD 1458



 Score =  131 bits (330), Expect = 7e-30
 Identities = 157/736 (21%), Positives = 301/736 (40%), Gaps = 139/736 (18%)

Query: 79   RKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE 138
            R+  +  +    F ++++  +  N + ++ E +   D  T +     K     + +F  E
Sbjct: 513  RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV---LLALFTCE 569

Query: 139  AGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLR 196
              +K+ +LG      +Y  + +N  D  VV  GI  T        + + +   R VR+LR
Sbjct: 570  MLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 625

Query: 197  PLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS 256
              K+     SL  ++ S++ +M  +  + LLLF  I++F+++G++ + GK +        
Sbjct: 626  IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------- 677

Query: 257  GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY 316
                 FD                          + FDN   A+LTVFQ +T E W  V+Y
Sbjct: 678  -----FDETQTKR--------------------STFDNFPQALLTVFQILTGEDWNAVMY 712

Query: 317  NTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAK-------ERERVENR 364
            +   A G   +      +YFI L I G++ +LN+ L +     A        ++E  E +
Sbjct: 713  DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEK 772

Query: 365  RAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT 424
                K+ R++ +E + N      +K E   +A  +            + TI   R E   
Sbjct: 773  ER-KKIARKESLENKKN------NKPEVNQIANSDN-----------KVTIDDYREEDED 814

Query: 425  RD----------------SSDEHCVDISSVGTPLARASIKSAKV---DGVSYF-RHKERL 464
            +D                  DE  V        ++  ++K       +G ++F   K   
Sbjct: 815  KDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNP 874

Query: 465  LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH-NQPQWLTHLLYYAEFLFLGLFLLEM 523
            +R+    ++   +F  ++L  + L++A +A         +   +L Y ++ F  +F +E+
Sbjct: 875  IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEI 934

Query: 524  SLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
             LKM   G  L    +  + FN  D  V   S+  V + I     S  + +LR LR+LR 
Sbjct: 935  LLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLRP 991

Query: 580  FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN--------- 630
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+F          
Sbjct: 992  LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1051

Query: 631  ----------FNDGTPSA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
                      + DG   +             NFD   +A+M +F + T E W  ++Y  I
Sbjct: 1052 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1111

Query: 668  RSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 722
             S G     +++     +I+FI+  +   + ++N+F+   +       E  K+ +  E  
Sbjct: 1112 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELD 1169

Query: 723  FNQKHALQKAKEVSPM 738
             NQ+  ++ A +  P+
Sbjct: 1170 KNQRQCVEYALKARPL 1185



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 66/267 (24%), Positives = 122/267 (45%), Gaps = 68/267 (25%)

Query: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIILT----- 1560
            L+ +  AF ++F++E  LK+IA+G L     Y R+ WN+ DF+ VI  +  +IL      
Sbjct: 161  LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKE 220

Query: 1561 ----DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1616
                +     + GF++  L+ FR  R ++L+    +++++L + +++   L ++ LL+  
Sbjct: 221  TEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 280

Query: 1617 LFFIYAIIGMQVF------------GNIKLDEE------SHINRH--------------- 1643
            +  IYAIIG+++F             +I  +E+      S   R                
Sbjct: 281  VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGP 340

Query: 1644 ----NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLA 1699
                 NF +F  +++ +F+  T E W +++                     N+  G +L 
Sbjct: 341  NGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------------------NDAMGFELP 382

Query: 1700 YVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
            +VYFVS + F SF +LNL + V+   F
Sbjct: 383  WVYFVSLVIFGSFFVLNLVLGVLSGEF 409


>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
            subunit [Homo sapiens]
          Length = 1873

 Score =  729 bits (1882), Expect = 0.0
 Identities = 395/874 (45%), Positives = 555/874 (63%), Gaps = 44/874 (5%)

Query: 1044 RVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPL-VDSTVVHISNKTDGEASPLKEA 1102
            R +S+  PD S    +T     E       IP    L +D    +++   D   S     
Sbjct: 684  RKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPG 743

Query: 1103 EIREDEEEVEKKKQKK-----EKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEM 1157
            +  EDE E+    + +     + +E    +   SS FIFS TN IR  CH IVN  +F  
Sbjct: 744  DDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTN 803

Query: 1158 CILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSY 1217
             ILL I  SS ALAAEDP+  +S RN++L++FD  FT VFT E+V+KM   G  L  GS+
Sbjct: 804  FILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSF 863

Query: 1218 FRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKA 1277
             R+ +N+LD +VV  +L++  L ++        I  +K LRVLRVLRPL+ I R   LK 
Sbjct: 864  CRNYFNMLDLLVVAVSLISMGLESSA-------ISVVKILRVLRVLRPLRAINRAKGLKH 916

Query: 1278 VFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV--- 1334
            V  C+  ++  + NI++V  L  F+FA I VQLFKGKFF CTD SK TE+EC G Y    
Sbjct: 917  VVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYK 976

Query: 1335 DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRS 1394
            D +  ++E++ REW   +FH+DN++ A+++LFTVST EGWPQ+L  ++D   ED GP  +
Sbjct: 977  DGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYN 1036

Query: 1395 NRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAK 1454
            NR+EM+IF+++Y ++  FF +NIFV  +I+TFQEQG+   + C L+KN+R C+ +A+ A+
Sbjct: 1037 NRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKAR 1096

Query: 1455 PLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLN 1514
            PL  Y+P+N   +QY+VW+ V S  FEY + A+I LNT+ L M++Y+           LN
Sbjct: 1097 PLRCYIPKN--PYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILN 1154

Query: 1515 IAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILT--DSKLVNTSGF-- 1570
            +AFT++F+LE +LK++AF    YF D WN+FDF+ VIGSI ++IL+  D+ L ++ G   
Sbjct: 1155 VAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYC 1214

Query: 1571 ----------------NMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLI 1614
                            + +F +LFR  RLIKLL +   +R LLWTF++SF+ALPYV LLI
Sbjct: 1215 LGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI 1274

Query: 1615 AMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLG 1674
             MLFFIYA+IGMQ+FG I L + + INR+NNF++F  +++LLFR ATGEAWQEI+L+C  
Sbjct: 1275 VMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSY 1334

Query: 1675 EKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSS 1734
             K C+P++    G  E   CGT+ AY YF+SF   C+FL++NLFVAVIMDNF+YLTRD S
Sbjct: 1335 GKLCDPESDYAPG--EEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWS 1392

Query: 1735 ILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMN 1794
            ILGPHHLDEF  +WAEYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV MN
Sbjct: 1393 ILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMN 1452

Query: 1795 MPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLL 1854
            MP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K+LD +
Sbjct: 1453 MPLNSDGTVTFNATLFALVRTALKIKTE---GNFEQANEELRAIIKKIWKRTSMKLLDQV 1509

Query: 1855 VPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1888
            +P     ++TVGK YA  +I +++++  +K+Q +
Sbjct: 1510 IPPIGDDEVTVGKFYATFLIQEHFRKF-MKRQEE 1542



 Score =  607 bits (1566), Expect = e-173
 Identities = 328/678 (48%), Positives = 433/678 (63%), Gaps = 50/678 (7%)

Query: 67  RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEK 126
           R+LF    +N +RK    +++W PFE +IL TI ANC+ LA+   +PEDD   ++  LEK
Sbjct: 29  RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88

Query: 127 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT---- 182
            E +F+ +F  EA +KI+A GF+FH+ +YLR+GWNV+DF +V  G+        N     
Sbjct: 89  LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148

Query: 183 ---------HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAIL 233
                     +D++ LRA RVLRPL+LVSG+PSLQ+VL SI KAM+PL  I LL+ F ++
Sbjct: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208

Query: 234 MFAIIGLEFYSGKLHRACFMNNSGILEGFD--PPHPCGVQGCPA-----GYECKD-WIGP 285
           ++AIIGLE + GK+H+ C+   + I+   +   P PC   G        G EC+  W GP
Sbjct: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268

Query: 286 NDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNL 345
           N GIT FDN  F++LTV+QCITMEGWT VLY  NDA+G  W W+YF+ LI++GSFF+LNL
Sbjct: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328

Query: 346 VLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTS 405
           VLGVLSGEF KERE+ ++R  F KLR +QQ++ +L GY +WI + E VM  E+ +    S
Sbjct: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGE-VMDVEDFREGKLS 387

Query: 406 ALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLL 465
             E                  S  E   +I+ +          +  +  + ++R   R+ 
Sbjct: 388 LDE----------------GGSDTESLYEIAGL----------NKIIQFIRHWRQWNRIF 421

Query: 466 RISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSL 525
           R     +VKS+VFYW+V+ +VALNT  +A  HHNQP WLT L   A  + L LF  EM +
Sbjct: 422 RWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLM 481

Query: 526 KMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKY 585
           KMYG+G R YF S FN FD  V    I E++       T  GISVLR +RLLRIFKITKY
Sbjct: 482 KMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKY 541

Query: 586 WASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFP 644
           W SL NLV SL++S++SI SLL LLFLFIV+FALLGMQLFGGR++F D     +NFD FP
Sbjct: 542 WTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFP 601

Query: 645 AAIMTVFQILTGEDWNEVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAV 703
            A+++VFQ+LTGEDW  +MYNGI + GG S  GM   IYFI+L + GNY LLNVFLAIAV
Sbjct: 602 QALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAV 661

Query: 704 DNLANAQELTKDEQEEEE 721
           DNLA A+ LT  ++ + E
Sbjct: 662 DNLAEAESLTSAQKAKAE 679



 Score =  208 bits (529), Expect = 6e-53
 Identities = 173/685 (25%), Positives = 312/685 (45%), Gaps = 96/685 (14%)

Query: 1108 EEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASS 1167
            +E + KK+ KK   E      P  ++F  +  NP+R+AC  IV  + FE  ILL I A+ 
Sbjct: 8    DEGLRKKQPKKPVPEILPR--PPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANC 65

Query: 1168 IALAAEDPVLT--NSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNIL 1225
            +ALA   P+    N+  N  L   +Y F  VF+ E  +K+I  G +    +Y R  WN+L
Sbjct: 66   VALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVL 125

Query: 1226 DFVVVVGALVAFALAN--------ALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKA 1277
            DF +V   +    L          A  ++KG  +  +K+LR  RVLRPL+ +  +P L+ 
Sbjct: 126  DFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVPSLQV 184

Query: 1278 VFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTEKE---- 1328
            V + +  ++  +F+I ++    + I+A+I ++LFKGK     +F  TD     E E    
Sbjct: 185  VLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSP 244

Query: 1329 C--IGNYVDHEKNKMEVKGREWKRHEF---HYDNIIWALLTLFTVSTGEGWPQVLQHSVD 1383
            C   G+      N  E +G  W        H+DN  +++LT++   T EGW  VL    D
Sbjct: 245  CARTGSGRRCTINGSECRG-GWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVND 303

Query: 1384 VTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMM 1434
                +            I++V   ++  FF +N+ + ++   F ++ +         K+ 
Sbjct: 304  AIGNE---------WPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLR 354

Query: 1435 EECSLEKNERACIDFAISAKPL----------------------------------TRYM 1460
            E+  L+++ R  + +    + +                                   R+ 
Sbjct: 355  EKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHW 414

Query: 1461 PQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMV 1520
             Q    F+++    V S  F + ++ ++ALNT+ +  ++++ P          N     +
Sbjct: 415  RQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSL 474

Query: 1521 FSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRA 1580
            F+ E ++K+   G   YF   +N FD   V   I EI+L +S  +   G  +S L+  R 
Sbjct: 475  FTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG--ISVLRCIRL 532

Query: 1581 ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHI 1640
             R+ K+ +   ++  L+ + + S +++  + LL+ +   I+A++GMQ+FG  + D E   
Sbjct: 533  LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-RYDFEDTE 591

Query: 1641 NRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAY 1700
             R +NF +F  +L+ +F+  TGE W  +M + +   G       PS           L  
Sbjct: 592  VRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG------GPSYPGM-------LVC 638

Query: 1701 VYFVSFIFFCSFLMLNLFVAVIMDN 1725
            +YF+      ++++LN+F+A+ +DN
Sbjct: 639  IYFIILFVCGNYILLNVFLAIAVDN 663



 Score =  135 bits (340), Expect = 5e-31
 Identities = 153/716 (21%), Positives = 299/716 (41%), Gaps = 119/716 (16%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F ++++  +  N + +A E H   +    ++R  +      + +F  E  +K+  LG   
Sbjct: 434  FYWLVILIVALNTLSIASEHH---NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGL-- 488

Query: 151  HKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLRPLKLVSGIPSLQ 208
                Y  + +N  D  VV SGIL          T + +  LR +R+LR  K+     SL 
Sbjct: 489  --RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLS 546

Query: 209  IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
             ++ S++ ++  +  + LLLF  I++FA++G++ + G+                      
Sbjct: 547  NLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGR---------------------- 584

Query: 269  GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWN- 327
                    Y+ +D        + FDN   A+++VFQ +T E WT+++YN   A G     
Sbjct: 585  --------YDFED---TEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYP 633

Query: 328  ----WLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGY 383
                 +YFI L + G++ +LN+ L +     A+       ++A  + ++++++ + L   
Sbjct: 634  GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLP-- 691

Query: 384  RAWIDKAEEVM------LAEENKNAGTSALEVLRRATIKRSRTEAMTR---------DSS 428
                DK+EE        L ++ K  G      L+    + +  E             D  
Sbjct: 692  ----DKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEE 747

Query: 429  DEHCVDISSVGTPLARASIKSAKV---DGVSYFRHKE-RLLRISIRHMVKSQVFYWIVLS 484
            DE  + +S    PLA   +K   V   +  S+F       +R+    +V +  F   +L 
Sbjct: 748  DEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILL 807

Query: 485  LVALNTACVAIVHHNQPQWLTH-LLYYAEFLFLGLFLLEMSLKMYGMGPRL----YFHSS 539
             + L++A +A     +   + + +L + +  F  +F +E+ LKM   G  L    +  + 
Sbjct: 808  FILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNY 867

Query: 540  FNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSS 599
            FN  D  V   S+  +            + +LR LR+LR  +       L+++V  +  +
Sbjct: 868  FNMLDLLVVAVSLISMG---LESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVA 924

Query: 600  MKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP---- 636
            + +I +++ +  L   +FA +G+QLF G+F                    + DG P    
Sbjct: 925  ISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIE 984

Query: 637  ---------SANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWS-----AIY 682
                       +FD   +A+M++F + T E W +++Y  I S       +++     AI+
Sbjct: 985  LRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIF 1044

Query: 683  FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM 738
            FI+  +   + ++N+F+   +       E      E ++  NQ+  +Q A +  P+
Sbjct: 1045 FIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK--NQRQCVQYALKARPL 1098



 Score =  110 bits (276), Expect = 1e-23
 Identities = 74/282 (26%), Positives = 135/282 (47%), Gaps = 41/282 (14%)

Query: 471  HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
            ++V S  F +++ +L+ LNT C+ + H+NQ + + H+       F  +F LEM LK+   
Sbjct: 1113 YIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAF 1172

Query: 531  GPRLYFHSSFNCFDFGVTVGSIFEVVWAIF--------------------RPGTSFGIS- 569
              R YF   +N FDF + +GSI +V+ +                       P  S  IS 
Sbjct: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232

Query: 570  -VLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGR 628
               R  R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+F G+
Sbjct: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291

Query: 629  FNFNDGTP---SANFDTFPAAIMTVFQILTGEDWNEVMY------------NGIRSQGGV 673
                DGT    + NF TFP A++ +F+  TGE W E++             +    +   
Sbjct: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYT 1351

Query: 674  SSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
                ++  YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1352 CGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTRD 1390



 Score =  107 bits (268), Expect = 1e-22
 Identities = 83/321 (25%), Positives = 153/321 (47%), Gaps = 26/321 (8%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            S FIF   N +R    ++++   F   IL  I+ +   LA E  +  D     ++ L+  
Sbjct: 778  SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILKHF 835

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
            +  F  +F  E  +K+   G   HKGS+ RN +N++D +VV   +++  G   +    ++
Sbjct: 836  DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM-GLESSAISVVK 894

Query: 188  TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
             LR +RVLRPL+ ++    L+ V++ +  A+  +  I L+      MFA IG++ + GK 
Sbjct: 895  ILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKF 954

Query: 248  HRACFMNN------SGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLT 301
             R   ++        G    +    P  ++        ++W+  +     FDN+L A+++
Sbjct: 955  FRCTDLSKMTEEECRGYYYVYKDGDPMQIE-----LRHREWVHSD---FHFDNVLSAMMS 1006

Query: 302  VFQCITMEGWTTVLYNTNDA----LGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSG 352
            +F   T EGW  +LY   D+    +G  +N      ++FI  II+ +FF++N+ +G +  
Sbjct: 1007 LFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIV 1066

Query: 353  EFAKERERVENRRAFMKLRRQ 373
             F ++ E         K +RQ
Sbjct: 1067 TFQEQGETEYKNCELDKNQRQ 1087



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 80/307 (26%), Positives = 145/307 (47%), Gaps = 56/307 (18%)

Query: 1143 RRACHYIVNLRYFEMCILLVIAASSIALAAE---DPVLTNSERNKVLRYFDYVFTGVFTF 1199
            R  CH IV  + F   ++L++A +++++A+E    P+     ++   R    V   +FT 
Sbjct: 422  RWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANR----VLLSLFTT 477

Query: 1200 EMVIKMIDQGLILQDGSYFRDLWNILD-FVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
            EM++KM   GL      YF  ++N  D FVV  G L    + +   T  G     I  LR
Sbjct: 478  EMLMKMYGLGL----RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG-----ISVLR 528

Query: 1259 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYC 1318
             +R+LR  K  K    L  +   ++ S++++ ++L++  LF+ IFA++ +QLF G++ + 
Sbjct: 529  CIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDF- 587

Query: 1319 TDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVL 1378
                +DTE                           ++DN   AL+++F V TGE W  ++
Sbjct: 588  ----EDTEV-----------------------RRSNFDNFPQALISVFQVLTGEDWTSMM 620

Query: 1379 QHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECS 1438
             + +       GPS    M + I++++ FV   +  +N+F+A+ +       D + E  S
Sbjct: 621  YNGIMAY---GGPSYPG-MLVCIYFIILFVCGNYILLNVFLAIAV-------DNLAEAES 669

Query: 1439 LEKNERA 1445
            L   ++A
Sbjct: 670  LTSAQKA 676



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 71/304 (23%), Positives = 129/304 (42%), Gaps = 76/304 (25%)

Query: 1480 FEYTIMAMIALNTVVLMMKYYSAP----CTYELALKYLNIAFTMVFSLECVLKVIAFGFL 1535
            FE  I+  I  N V L + Y   P     +  L L+ L   F +VFS+E  +K+IA+GFL
Sbjct: 53   FETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFL 111

Query: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNT---------SGFNMSFLKLFRAAR 1582
                 Y R  WN+ DF  V   +  +IL    ++ +         +G ++  L+ FR  R
Sbjct: 112  FHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLR 171

Query: 1583 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------- 1629
             ++L+    +++++L +  ++   L ++ LL+  +  IYAIIG+++F             
Sbjct: 172  PLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGT 231

Query: 1630 ---GNIKLDEESHINRHNN------------------------FRSFFGSLMLLFRSATG 1662
                 ++ +E S   R  +                        F +F  S++ +++  T 
Sbjct: 232  DIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITM 291

Query: 1663 EAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVI 1722
            E W +++                     N+  G +  ++YFV+ I   SF +LNL + V+
Sbjct: 292  EGWTDVLYWV------------------NDAIGNEWPWIYFVTLILLGSFFILNLVLGVL 333

Query: 1723 MDNF 1726
               F
Sbjct: 334  SGEF 337



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 79/304 (25%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            FEY++ A I+ N I L ++ +   +    +S  L      F  IF  E  +K++A    F
Sbjct: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172

Query: 151  HKGSYLRNGWNVMDFIVVLSGI-----------LATAGTHF-------------NTHVDL 186
                Y  + WNV DF++V+  I           LA++G  +             +  +  
Sbjct: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232

Query: 187  RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
               R  RV+R +KL+S    ++ +L + +K+   L  + LL+     ++A+IG++ + GK
Sbjct: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291

Query: 247  LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCI 306
            +          +++G                     I  N+    F     AVL +F+C 
Sbjct: 1292 I---------ALVDGTQ-------------------INRNNNFQTFPQ---AVLLLFRCA 1320

Query: 307  TMEGWTTVLY----------------NTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVL 350
            T E W  +L                       G  + + YFI   ++ +F V+NL + V+
Sbjct: 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380

Query: 351  SGEF 354
               F
Sbjct: 1381 MDNF 1384


>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform b [Homo sapiens]
          Length = 2161

 Score =  727 bits (1877), Expect = 0.0
 Identities = 380/816 (46%), Positives = 539/816 (66%), Gaps = 40/816 (4%)

Query: 1098 PLKEAEIREDEEEVEKKKQKKEKRETGKAM------VPH-SSMFIFSTTNPIRRACHYIV 1150
            P+ E E  E+E+E E     + +R +   M      +P  S+ FI S TNPIR  CH ++
Sbjct: 824  PVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLI 883

Query: 1151 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL 1210
            N   F   IL+ I  SS ALAAEDP+ ++S RN +L YFDY FT +FT E+++KM   G 
Sbjct: 884  NHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGA 943

Query: 1211 ILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1270
             L  G++ R+ +N+LD +VV  +LV+F + ++        I  +K LRVLRVLRPL+ I 
Sbjct: 944  FLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-------ISVVKILRVLRVLRPLRAIN 996

Query: 1271 RLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI 1330
            R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGKF+ CTD +K   +EC 
Sbjct: 997  RAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECR 1056

Query: 1331 GNYV---DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
            G ++   D + +   V+ R W+  +F++DN++ A++ LFTVST EGWP +L  ++D   E
Sbjct: 1057 GLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGE 1116

Query: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACI 1447
            + GP  ++R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG+K  + C L+KN+R C+
Sbjct: 1117 NIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCV 1176

Query: 1448 DFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYE 1507
            ++A+ A+PL RY+P+N   +QY+ W+ V S  FEY +  +I LNT+ L M++Y     + 
Sbjct: 1177 EYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1234

Query: 1508 LALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIIL-----TDS 1562
             A+  LN+ FT VF++E VLKVIAF    YF D WN FD + VIGSI ++ L     T+S
Sbjct: 1235 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTES 1294

Query: 1563 KLV-----------NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1611
            + V            ++  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV 
Sbjct: 1295 ENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1354

Query: 1612 LLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLS 1671
            LLIAMLFFIYA+IGMQ+FG + + + + INR+NNF++F  +++LLFR ATGEAWQEIML+
Sbjct: 1355 LLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1414

Query: 1672 CLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTR 1731
            CL  K C+P++    G  E   CG++ A VYF+SF   C+FL++NLFVAVIMDNF+YLTR
Sbjct: 1415 CLPGKLCDPESDYNPG--EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTR 1472

Query: 1732 DSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLV 1791
            D SILGPHHLDEF R+W+EYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV
Sbjct: 1473 DWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1532

Query: 1792 LMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKML 1851
             MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K+L
Sbjct: 1533 AMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLL 1589

Query: 1852 DLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQR 1887
            D +VP     ++TVGK YA  +I DY+++ K +K++
Sbjct: 1590 DQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQ 1625



 Score =  618 bits (1593), Expect = e-176
 Identities = 362/775 (46%), Positives = 478/775 (61%), Gaps = 51/775 (6%)

Query: 12  PGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPV-------RQNCFT 64
           P SG+G + Q  + + T +  S QAA     +A+ A+TM+   P PV       RQ    
Sbjct: 33  PLSGEGPTSQPNSSKQTVL--SWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK 90

Query: 65  VN-----------RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLP 113
                        R+LF    +N +R+    +++W PF+  IL  I ANC+ LA+    P
Sbjct: 91  SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFP 150

Query: 114 EDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL 173
           EDD    +  LEK E  F+ IF  E  +KI+A G + H  +Y+RNGWN++DF++V+ G+ 
Sbjct: 151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF 210

Query: 174 A------TAGTHFNTH-------VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVP 220
           +      T  T    H        D++ LRA RVLRPL+LVSG+PSLQ+VL SI+KAMVP
Sbjct: 211 SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 270

Query: 221 LLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPA- 275
           LL I LL+ F I+++AIIGLE + GK+H+ CF  +S I+   DP  PC   G    C A 
Sbjct: 271 LLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPA-PCAFSGNGRQCTAN 329

Query: 276 GYECKD-WIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
           G EC+  W+GPN GIT FDN  FA+LTVFQCITMEGWT VLY  NDA+G    W+YF+ L
Sbjct: 330 GTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSL 389

Query: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
           +I GSFFVLNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +L GY  WI +AE++ 
Sbjct: 390 VIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI- 448

Query: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDG 454
              EN+  G    E  R  ++  S TE++  ++      +    G+ L +A  KS     
Sbjct: 449 -DPENEEEGGE--EGKRNTSMPTSETESVNTENVSGEGENRGCCGS-LCQAISKSKLS-- 502

Query: 455 VSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFL 514
              +R   R  R   R  VKS  FYW+V+ LV LNT  ++  H+NQP WLT +   A  +
Sbjct: 503 -RRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV 561

Query: 515 FLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRAL 574
            L LF  EM +KMY +G + YF S FN FD  V  G I E +       +  GISV R +
Sbjct: 562 LLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCV 621

Query: 575 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFND- 633
           RLLRIFK+T++W SL NLV SL++SMKSI SLL LLFLFI++F+LLGMQLFGG+FNF++ 
Sbjct: 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDET 681

Query: 634 GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG-VSSGMWSAIYFIVLTLFGNY 692
            T  + FD FP A++TVFQILTGEDWN VMY+GI + GG  SSGM   IYFI+L + GNY
Sbjct: 682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 741

Query: 693 TLLNVFLAIAVDNLANAQEL-TKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSI 746
            LLNVFLAIAVDNLA+A+ L T  ++E EE   +K A +++ E    + P +  I
Sbjct: 742 ILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQI 796



 Score =  213 bits (541), Expect = 2e-54
 Identities = 173/704 (24%), Positives = 322/704 (45%), Gaps = 121/704 (17%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+       P  ++F  S  NPIRRAC  IV  + F++ ILL I A+ +
Sbjct: 82   QRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCV 141

Query: 1169 ALAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD 1226
            ALA   P   +     N  L   +Y F  +FT E  +K+I  GL+L   +Y R+ WN+LD
Sbjct: 142  ALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD 201

Query: 1227 FVVVVGALVAFALANALGTNKGRDIKT-------IKSLRVLRVLRPLKTIKRLPKLKAVF 1279
            FV+V+  L +  L       +G +  +       +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 202  FVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVL 261

Query: 1280 DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTE-------- 1326
            + ++ ++  + +I ++    + I+A+I ++LF GK     FF  +D   + +        
Sbjct: 262  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSG 321

Query: 1327 --KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDV 1384
              ++C  N  +     +   G        ++DN  +A+LT+F   T EGW  VL    D 
Sbjct: 322  NGRQCTANGTECRSGWVGPNG-----GITNFDNFAFAMLTVFQCITMEGWTDVLYWMND- 375

Query: 1385 TEEDRGPSRSNRMEMSIFYVVYFVVFPFFFV-NIFVALIIITFQEQ-------GD--KMM 1434
                     +   E+   Y V  V+F  FFV N+ + ++   F ++       GD  K+ 
Sbjct: 376  ---------AMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLR 426

Query: 1435 EECSLEKNERACIDFAISAK---------------------------------------- 1454
            E+  LE++ +  +D+   A+                                        
Sbjct: 427  EKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR 486

Query: 1455 ----PLTRYMPQNRHTFQYRVWH---------FVVSPSFEYTIMAMIALNTVVLMMKYYS 1501
                 L + + +++ + ++R W+          V S +F + ++ ++ LNT+ +  ++Y+
Sbjct: 487  GCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYN 546

Query: 1502 APCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD 1561
             P          N     +F+ E ++K+ + G   YF   +N FD   V G ITE IL +
Sbjct: 547  QPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVE 606

Query: 1562 SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1621
             ++++  G  +S  +  R  R+ K+ R   ++  L+ + + S K++  + LL+ +   I+
Sbjct: 607  LEIMSPLG--ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIF 664

Query: 1622 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPD 1681
            +++GMQ+FG  K + +    + + F +F  +L+ +F+  TGE W  +M   +   G    
Sbjct: 665  SLLGMQLFGG-KFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG---- 719

Query: 1682 TTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
               PS           +  +YF+      ++++LN+F+A+ +DN
Sbjct: 720  --GPSSSGM-------IVCIYFIILFICGNYILLNVFLAIAVDN 754



 Score =  189 bits (479), Expect = 3e-47
 Identities = 171/699 (24%), Positives = 301/699 (43%), Gaps = 141/699 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FI  + N +R    KLI+   F  +IL  I+ +   LA E   P    +  +  L   
Sbjct: 865  AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 922

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGI-LATAGTHFNTHVDL 186
            +  F  IF  E  +K+   G   HKG++ RN +N++D +VV  G+ L + G   +    +
Sbjct: 923  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 980

Query: 187  RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
            + LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GK
Sbjct: 981  KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1040

Query: 247  LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGP-------NDGITQFDNILFAV 299
             +R      S        P  C  +G    Y+  D   P        +    FDN+L A+
Sbjct: 1041 FYRCTDEAKSN-------PEEC--RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAM 1091

Query: 300  LTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLGVL 350
            + +F   T EGW  +LY   D+    +G  +N      ++FI  III +FF++N+ +G  
Sbjct: 1092 MALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG-- 1149

Query: 351  SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVL 410
                            F+ +  Q+Q E+E                               
Sbjct: 1150 ----------------FVIVTFQEQGEKEYKNCEL------------------------- 1168

Query: 411  RRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIR 470
                           D +   CV+ +    PL R   K+        +++K         
Sbjct: 1169 ---------------DKNQRQCVEYALKARPLRRYIPKNP-------YQYK-------FW 1199

Query: 471  HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
            ++V S  F +++  L+ LNT C+A+ H+ Q +     +     +F G+F +EM LK+   
Sbjct: 1200 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259

Query: 531  GPRLYFHSSFNCFDFGVTVGSIFEVVWA-------------IFRPGTS-----FGISVLR 572
             P+ YF  ++N FD  + +GSI +V  +                PG S       I+  R
Sbjct: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1319

Query: 573  ALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG--GRFN 630
              R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG     +
Sbjct: 1320 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRD 1379

Query: 631  FNDGTPSANFDTFPAAIMTVFQILTGEDWNEVM--------------YNGIRSQGGVSSG 676
             N    + NF TFP A++ +F+  TGE W E+M              YN    +      
Sbjct: 1380 NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYN--PGEEYTCGS 1437

Query: 677  MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
             ++ +YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1438 NFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1473



 Score =  131 bits (330), Expect = 7e-30
 Identities = 157/736 (21%), Positives = 301/736 (40%), Gaps = 139/736 (18%)

Query: 79   RKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE 138
            R+  +  +    F ++++  +  N + ++ E +   D  T +     K     + +F  E
Sbjct: 513  RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV---LLALFTCE 569

Query: 139  AGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLR 196
              +K+ +LG      +Y  + +N  D  VV  GI  T        + + +   R VR+LR
Sbjct: 570  MLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 625

Query: 197  PLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS 256
              K+     SL  ++ S++ +M  +  + LLLF  I++F+++G++ + GK +        
Sbjct: 626  IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------- 677

Query: 257  GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY 316
                 FD                          + FDN   A+LTVFQ +T E W  V+Y
Sbjct: 678  -----FDETQTKR--------------------STFDNFPQALLTVFQILTGEDWNAVMY 712

Query: 317  NTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAK-------ERERVENR 364
            +   A G   +      +YFI L I G++ +LN+ L +     A        ++E  E +
Sbjct: 713  DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEK 772

Query: 365  RAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT 424
                K+ R++ +E + N      +K E   +A  +            + TI   R E   
Sbjct: 773  ER-KKIARKESLENKKN------NKPEVNQIANSDN-----------KVTIDDYREEDED 814

Query: 425  RD----------------SSDEHCVDISSVGTPLARASIKSAKV---DGVSYF-RHKERL 464
            +D                  DE  V        ++  ++K       +G ++F   K   
Sbjct: 815  KDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNP 874

Query: 465  LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH-NQPQWLTHLLYYAEFLFLGLFLLEM 523
            +R+    ++   +F  ++L  + L++A +A         +   +L Y ++ F  +F +E+
Sbjct: 875  IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEI 934

Query: 524  SLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
             LKM   G  L    +  + FN  D  V   S+  V + I     S  + +LR LR+LR 
Sbjct: 935  LLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLRP 991

Query: 580  FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN--------- 630
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+F          
Sbjct: 992  LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1051

Query: 631  ----------FNDGTPSA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
                      + DG   +             NFD   +A+M +F + T E W  ++Y  I
Sbjct: 1052 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1111

Query: 668  RSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 722
             S G     +++     +I+FI+  +   + ++N+F+   +       E  K+ +  E  
Sbjct: 1112 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELD 1169

Query: 723  FNQKHALQKAKEVSPM 738
             NQ+  ++ A +  P+
Sbjct: 1170 KNQRQCVEYALKARPL 1185



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 66/267 (24%), Positives = 122/267 (45%), Gaps = 68/267 (25%)

Query: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIILT----- 1560
            L+ +  AF ++F++E  LK+IA+G L     Y R+ WN+ DF+ VI  +  +IL      
Sbjct: 161  LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKE 220

Query: 1561 ----DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1616
                +     + GF++  L+ FR  R ++L+    +++++L + +++   L ++ LL+  
Sbjct: 221  TEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 280

Query: 1617 LFFIYAIIGMQVF------------GNIKLDEE------SHINRH--------------- 1643
            +  IYAIIG+++F             +I  +E+      S   R                
Sbjct: 281  VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGP 340

Query: 1644 ----NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLA 1699
                 NF +F  +++ +F+  T E W +++                     N+  G +L 
Sbjct: 341  NGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------------------NDAMGFELP 382

Query: 1700 YVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
            +VYFVS + F SF +LNL + V+   F
Sbjct: 383  WVYFVSLVIFGSFFVLNLVLGVLSGEF 409


>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform a [Homo sapiens]
          Length = 2181

 Score =  727 bits (1877), Expect = 0.0
 Identities = 380/816 (46%), Positives = 539/816 (66%), Gaps = 40/816 (4%)

Query: 1098 PLKEAEIREDEEEVEKKKQKKEKRETGKAM------VPH-SSMFIFSTTNPIRRACHYIV 1150
            P+ E E  E+E+E E     + +R +   M      +P  S+ FI S TNPIR  CH ++
Sbjct: 844  PVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLI 903

Query: 1151 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL 1210
            N   F   IL+ I  SS ALAAEDP+ ++S RN +L YFDY FT +FT E+++KM   G 
Sbjct: 904  NHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGA 963

Query: 1211 ILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1270
             L  G++ R+ +N+LD +VV  +LV+F + ++        I  +K LRVLRVLRPL+ I 
Sbjct: 964  FLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-------ISVVKILRVLRVLRPLRAIN 1016

Query: 1271 RLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECI 1330
            R   LK V  CV  +++ + NI+IV  L  F+FA I VQLFKGKF+ CTD +K   +EC 
Sbjct: 1017 RAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECR 1076

Query: 1331 GNYV---DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
            G ++   D + +   V+ R W+  +F++DN++ A++ LFTVST EGWP +L  ++D   E
Sbjct: 1077 GLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGE 1136

Query: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACI 1447
            + GP  ++R+E+SIF+++Y ++  FF +NIFV  +I+TFQEQG+K  + C L+KN+R C+
Sbjct: 1137 NIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCV 1196

Query: 1448 DFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYE 1507
            ++A+ A+PL RY+P+N   +QY+ W+ V S  FEY +  +I LNT+ L M++Y     + 
Sbjct: 1197 EYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1254

Query: 1508 LALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIIL-----TDS 1562
             A+  LN+ FT VF++E VLKVIAF    YF D WN FD + VIGSI ++ L     T+S
Sbjct: 1255 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTES 1314

Query: 1563 KLV-----------NTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1611
            + V            ++  +++F +LFR  RL+KLL +G  IR LLWTF++SF+ALPYV 
Sbjct: 1315 ENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1374

Query: 1612 LLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLS 1671
            LLIAMLFFIYA+IGMQ+FG + + + + INR+NNF++F  +++LLFR ATGEAWQEIML+
Sbjct: 1375 LLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1434

Query: 1672 CLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTR 1731
            CL  K C+P++    G  E   CG++ A VYF+SF   C+FL++NLFVAVIMDNF+YLTR
Sbjct: 1435 CLPGKLCDPESDYNPG--EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTR 1492

Query: 1732 DSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLV 1791
            D SILGPHHLDEF R+W+EYD  A GRI + ++  +L  + PPLG GK CP +VA KRLV
Sbjct: 1493 DWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1552

Query: 1792 LMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKML 1851
             MNMP+  D TV F +TL AL+RTAL IK      + +Q + EL+     IW   S K+L
Sbjct: 1553 AMNMPLNSDGTVMFNATLFALVRTALKIKTE---GNLEQANEELRAVIKKIWKKTSMKLL 1609

Query: 1852 DLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQR 1887
            D +VP     ++TVGK YA  +I DY+++ K +K++
Sbjct: 1610 DQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQ 1645



 Score =  619 bits (1595), Expect = e-176
 Identities = 363/791 (45%), Positives = 481/791 (60%), Gaps = 63/791 (7%)

Query: 12  PGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPV-------RQNCFT 64
           P SG+G + Q  + + T +  S QAA     +A+ A+TM+   P PV       RQ    
Sbjct: 33  PLSGEGPTSQPNSSKQTVL--SWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK 90

Query: 65  VN-----------RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLP 113
                        R+LF    +N +R+    +++W PF+  IL  I ANC+ LA+    P
Sbjct: 91  SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFP 150

Query: 114 EDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGIL 173
           EDD    +  LEK E  F+ IF  E  +KI+A G + H  +Y+RNGWN++DF++V+ G+ 
Sbjct: 151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLF 210

Query: 174 A------TAGTHFNTH-------VDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVP 220
           +      T  T    H        D++ LRA RVLRPL+LVSG+PSLQ+VL SI+KAMVP
Sbjct: 211 SVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVP 270

Query: 221 LLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQG----CPA- 275
           LL I LL+ F I+++AIIGLE + GK+H+ CF  +S I+   DP  PC   G    C A 
Sbjct: 271 LLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPA-PCAFSGNGRQCTAN 329

Query: 276 GYECKD-WIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
           G EC+  W+GPN GIT FDN  FA+LTVFQCITMEGWT VLY  NDA+G  W W+YF+ L
Sbjct: 330 GTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSL 389

Query: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
           II+GSFFVLNLVLGVLSGEF+KERE+ + R  F KLR +QQ+E +L GY  WI +AE++ 
Sbjct: 390 IILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI- 448

Query: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGT--------PLARAS 446
              EN+  G    E  R  ++  S TE++  ++      +    G+          A+A 
Sbjct: 449 -DPENEEEGGE--EGKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAG 505

Query: 447 IKSAKVDGVSYFRHK--------ERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH 498
               +  G +  + K         R  R   R  VKS  FYW+V+ LV LNT  ++  H+
Sbjct: 506 PSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHY 565

Query: 499 NQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWA 558
           NQP WLT +   A  + L LF  EM +KMY +G + YF S FN FD  V  G I E +  
Sbjct: 566 NQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILV 625

Query: 559 IFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFA 618
                +  GISV R +RLLRIFK+T++W SL NLV SL++SMKSI SLL LLFLFI++F+
Sbjct: 626 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 685

Query: 619 LLGMQLFGGRFNFND-GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG-VSSG 676
           LLGMQLFGG+FNF++  T  + FD FP A++TVFQILTGEDWN VMY+GI + GG  SSG
Sbjct: 686 LLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 745

Query: 677 MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL-TKDEQEEEEAFNQKHALQKAKEV 735
           M   IYFI+L + GNY LLNVFLAIAVDNLA+A+ L T  ++E EE   +K A +++ E 
Sbjct: 746 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLEN 805

Query: 736 SPMSAPNMPSI 746
              + P +  I
Sbjct: 806 KKNNKPEVNQI 816



 Score =  189 bits (479), Expect = 3e-47
 Identities = 171/699 (24%), Positives = 301/699 (43%), Gaps = 141/699 (20%)

Query: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
            + FI  + N +R    KLI+   F  +IL  I+ +   LA E   P    +  +  L   
Sbjct: 885  AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED--PIRSHSFRNTILGYF 942

Query: 128  EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGI-LATAGTHFNTHVDL 186
            +  F  IF  E  +K+   G   HKG++ RN +N++D +VV  G+ L + G   +    +
Sbjct: 943  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV--GVSLVSFGIQSSAISVV 1000

Query: 187  RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
            + LR +RVLRPL+ ++    L+ V++ +  A+  +  I ++      MFA IG++ + GK
Sbjct: 1001 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK 1060

Query: 247  LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGP-------NDGITQFDNILFAV 299
             +R      S        P  C  +G    Y+  D   P        +    FDN+L A+
Sbjct: 1061 FYRCTDEAKSN-------PEEC--RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAM 1111

Query: 300  LTVFQCITMEGWTTVLYNTNDA----LGATWNW-----LYFIPLIIIGSFFVLNLVLGVL 350
            + +F   T EGW  +LY   D+    +G  +N      ++FI  III +FF++N+ +G  
Sbjct: 1112 MALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVG-- 1169

Query: 351  SGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVL 410
                            F+ +  Q+Q E+E                               
Sbjct: 1170 ----------------FVIVTFQEQGEKEYKNCEL------------------------- 1188

Query: 411  RRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIR 470
                           D +   CV+ +    PL R   K+        +++K         
Sbjct: 1189 ---------------DKNQRQCVEYALKARPLRRYIPKNP-------YQYK-------FW 1219

Query: 471  HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
            ++V S  F +++  L+ LNT C+A+ H+ Q +     +     +F G+F +EM LK+   
Sbjct: 1220 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1279

Query: 531  GPRLYFHSSFNCFDFGVTVGSIFEVVWA-------------IFRPGTS-----FGISVLR 572
             P+ YF  ++N FD  + +GSI +V  +                PG S       I+  R
Sbjct: 1280 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1339

Query: 573  ALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG--GRFN 630
              R++R+ K+      +R L+ + + S +++  +  L+ +   ++A++GMQ+FG     +
Sbjct: 1340 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRD 1399

Query: 631  FNDGTPSANFDTFPAAIMTVFQILTGEDWNEVM--------------YNGIRSQGGVSSG 676
             N    + NF TFP A++ +F+  TGE W E+M              YN    +      
Sbjct: 1400 NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYN--PGEEYTCGS 1457

Query: 677  MWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
             ++ +YFI   +   + ++N+F+A+ +DN      LT+D
Sbjct: 1458 NFAIVYFISFYMLCAFLIINLFVAVIMDNF---DYLTRD 1493



 Score =  134 bits (336), Expect = 1e-30
 Identities = 102/381 (26%), Positives = 183/381 (48%), Gaps = 50/381 (13%)

Query: 1112 EKKKQ---KKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSI 1168
            ++K+Q   K +K+       P  ++F  S  NPIRRAC  IV  + F++ ILL I A+ +
Sbjct: 82   QRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCV 141

Query: 1169 ALAAEDPVLTNSER--NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD 1226
            ALA   P   +     N  L   +Y F  +FT E  +K+I  GL+L   +Y R+ WN+LD
Sbjct: 142  ALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD 201

Query: 1227 FVVVVGALVAFALANALGTNKGRDIKT-------IKSLRVLRVLRPLKTIKRLPKLKAVF 1279
            FV+V+  L +  L       +G +  +       +K+LR  RVLRPL+ +  +P L+ V 
Sbjct: 202  FVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVL 261

Query: 1280 DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTE-------- 1326
            + ++ ++  + +I ++    + I+A+I ++LF GK     FF  +D   + +        
Sbjct: 262  NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSG 321

Query: 1327 --KECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDV 1384
              ++C  N  +     +   G        ++DN  +A+LT+F   T EGW  VL    D 
Sbjct: 322  NGRQCTANGTECRSGWVGPNG-----GITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376

Query: 1385 TEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-------GD--KMME 1435
               +            +++V   ++  FF +N+ + ++   F ++       GD  K+ E
Sbjct: 377  IGWE---------WPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLRE 427

Query: 1436 ECSLEKNERACIDFAISAKPL 1456
            +  LE++ +  +D+   A+ +
Sbjct: 428  KQQLEEDLKGYLDWITQAEDI 448



 Score =  131 bits (330), Expect = 7e-30
 Identities = 157/736 (21%), Positives = 301/736 (40%), Gaps = 139/736 (18%)

Query: 79   RKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE 138
            R+  +  +    F ++++  +  N + ++ E +   D  T +     K     + +F  E
Sbjct: 533  RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKV---LLALFTCE 589

Query: 139  AGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLR 196
              +K+ +LG      +Y  + +N  D  VV  GI  T        + + +   R VR+LR
Sbjct: 590  MLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645

Query: 197  PLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS 256
              K+     SL  ++ S++ +M  +  + LLLF  I++F+++G++ + GK +        
Sbjct: 646  IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-------- 697

Query: 257  GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLY 316
                 FD                          + FDN   A+LTVFQ +T E W  V+Y
Sbjct: 698  -----FDETQTKR--------------------STFDNFPQALLTVFQILTGEDWNAVMY 732

Query: 317  NTNDALGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSGEFAK-------ERERVENR 364
            +   A G   +      +YFI L I G++ +LN+ L +     A        ++E  E +
Sbjct: 733  DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEK 792

Query: 365  RAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMT 424
                K+ R++ +E + N      +K E   +A  +            + TI   R E   
Sbjct: 793  ER-KKIARKESLENKKN------NKPEVNQIANSDN-----------KVTIDDYREEDED 834

Query: 425  RD----------------SSDEHCVDISSVGTPLARASIKSAKV---DGVSYF-RHKERL 464
            +D                  DE  V        ++  ++K       +G ++F   K   
Sbjct: 835  KDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNP 894

Query: 465  LRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH-NQPQWLTHLLYYAEFLFLGLFLLEM 523
            +R+    ++   +F  ++L  + L++A +A         +   +L Y ++ F  +F +E+
Sbjct: 895  IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEI 954

Query: 524  SLKMYGMGPRL----YFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
             LKM   G  L    +  + FN  D  V   S+  V + I     S  + +LR LR+LR 
Sbjct: 955  LLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL--VSFGIQSSAISV-VKILRVLRVLRP 1011

Query: 580  FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN--------- 630
             +       L+++V  +  ++++I +++ +  L   +FA +G+QLF G+F          
Sbjct: 1012 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1071

Query: 631  ----------FNDGTPSA-------------NFDTFPAAIMTVFQILTGEDWNEVMYNGI 667
                      + DG   +             NFD   +A+M +F + T E W  ++Y  I
Sbjct: 1072 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1131

Query: 668  RSQGGVSSGMWS-----AIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEA 722
             S G     +++     +I+FI+  +   + ++N+F+   +       E  K+ +  E  
Sbjct: 1132 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE--KEYKNCELD 1189

Query: 723  FNQKHALQKAKEVSPM 738
             NQ+  ++ A +  P+
Sbjct: 1190 KNQRQCVEYALKARPL 1205



 Score =  104 bits (259), Expect = 1e-21
 Identities = 69/276 (25%), Positives = 136/276 (49%), Gaps = 16/276 (5%)

Query: 1450 AISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELA 1509
            AIS   L+R   +     + R    V S +F + ++ ++ LNT+ +  ++Y+ P      
Sbjct: 515  AISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQI 574

Query: 1510 LKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSG 1569
                N     +F+ E ++K+ + G   YF   +N FD   V G ITE IL + ++++  G
Sbjct: 575  QDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG 634

Query: 1570 FNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
              +S  +  R  R+ K+ R   ++  L+ + + S K++  + LL+ +   I++++GMQ+F
Sbjct: 635  --ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF 692

Query: 1630 GNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQN 1689
            G  K + +    + + F +F  +L+ +F+  TGE W  +M   +   G       PS   
Sbjct: 693  GG-KFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG------GPSSSG 745

Query: 1690 ENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
                    +  +YF+      ++++LN+F+A+ +DN
Sbjct: 746  M-------IVCIYFIILFICGNYILLNVFLAIAVDN 774



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 75/292 (25%), Positives = 133/292 (45%), Gaps = 63/292 (21%)

Query: 1143 RRACHYIVNLRYFEMCILLVIAASSIALAAED----PVLTNSE--RNKVLRYFDYVFTGV 1196
            RR C   V    F   +++++  +++ +++E       LT  +   NKVL         +
Sbjct: 533  RRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVL-------LAL 585

Query: 1197 FTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGA-----LVAFALANALGTNKGRDI 1251
            FT EM++KM   GL     +YF  L+N  D  VV G      LV   + + LG       
Sbjct: 586  FTCEMLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG------- 634

Query: 1252 KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLF 1311
              I   R +R+LR  K  +    L  +   ++ S+K++ ++L++  LF+ IF+++ +QLF
Sbjct: 635  --ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF 692

Query: 1312 KGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTG 1371
             GKF +    +K +                             +DN   ALLT+F + TG
Sbjct: 693  GGKFNFDETQTKRST----------------------------FDNFPQALLTVFQILTG 724

Query: 1372 EGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALII 1423
            E W  V+   +       GPS S+ M + I++++ F+   +  +N+F+A+ +
Sbjct: 725  EDWNAVMYDGIMAY---GGPS-SSGMIVCIYFIILFICGNYILLNVFLAIAV 772



 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 68/267 (25%)

Query: 1510 LKYLNIAFTMVFSLECVLKVIAFGFL----NYFRDTWNIFDFITVIGSITEIILT----- 1560
            L+ +  AF ++F++E  LK+IA+G L     Y R+ WN+ DF+ VI  +  +IL      
Sbjct: 161  LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKE 220

Query: 1561 ----DSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1616
                +     + GF++  L+ FR  R ++L+    +++++L + +++   L ++ LL+  
Sbjct: 221  TEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 280

Query: 1617 LFFIYAIIGMQVF------------GNIKLDEE------SHINRH--------------- 1643
            +  IYAIIG+++F             +I  +E+      S   R                
Sbjct: 281  VIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGP 340

Query: 1644 ----NNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLA 1699
                 NF +F  +++ +F+  T E W +++                     N+  G +  
Sbjct: 341  NGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV------------------NDAIGWEWP 382

Query: 1700 YVYFVSFIFFCSFLMLNLFVAVIMDNF 1726
            +VYFVS I   SF +LNL + V+   F
Sbjct: 383  WVYFVSLIILGSFFVLNLVLGVLSGEF 409


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score =  326 bits (836), Expect = 1e-88
 Identities = 247/827 (29%), Positives = 406/827 (49%), Gaps = 66/827 (7%)

Query: 1015 VGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAI 1074
            V KH++      E S  Q+ + N  L +   I+  E DL  + A    + ++S    V +
Sbjct: 1055 VDKHLM------EDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRL 1108

Query: 1075 PDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEE-------VEKKKQKKEKRETGKAM 1127
                    STV    N   GE    +   +  DE E       V +    +   E+GK  
Sbjct: 1109 NRSSSSECSTV---DNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGK 1165

Query: 1128 VPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKV-L 1186
            +  +          IR+ C+ IV   +FE  I+L+I  SS ALA ED  +   +  K+ L
Sbjct: 1166 IWWN----------IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIIL 1215

Query: 1187 RYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTN 1246
             Y D +FT +F  EM++K I  G      +YF + W  LDF++V  +LV   +AN LG +
Sbjct: 1216 EYADKIFTYIFILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTL-VANTLGYS 1270

Query: 1247 KGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVI 1306
               D+  IKSLR LR LRPL+ + R   ++ V + ++ ++ ++ N+L+V  +F  IF+++
Sbjct: 1271 ---DLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIM 1327

Query: 1307 AVQLFKGKFFYC---TDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALL 1363
             V LF GKF+ C   TD S+    + + N  +        +   WK  + ++DN+    L
Sbjct: 1328 GVNLFAGKFYECINTTDGSRFPASQ-VPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYL 1386

Query: 1364 TLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALII 1423
            +L  V+T +GW  ++  +VD    D+ P     + M I++VV+ +   FF +N+F+ +II
Sbjct: 1387 SLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVII 1446

Query: 1424 ITFQEQGDK-------MMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV 1476
              F +Q  K       M EE     N    +      KP+ R  P N+   Q  ++  V 
Sbjct: 1447 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PGNK--IQGCIFDLVT 1502

Query: 1477 SPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLN 1536
            + +F+ +IM +I LN V +M++           L ++N+ F ++F+ ECVLK+I+     
Sbjct: 1503 NQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHY- 1561

Query: 1537 YFRDTWNIFDFITVIGSITEIILTDSKLVNT---SGFNMSFLKLFRAARLIKLLRQGYTI 1593
            YF   WNIFDF+ VI SI  + L D  L+ T   S      ++L R  R+++L++    I
Sbjct: 1562 YFTVGWNIFDFVVVIISIVGMFLAD--LIETYFVSPTLFRVIRLARIGRILRLVKGAKGI 1619

Query: 1594 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSL 1653
            R LL+  + S  AL  + LL+ ++ FIYAI GM  F  +K  +E  IN   NF +F  S+
Sbjct: 1620 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK--KEDGINDMFNFETFGNSM 1677

Query: 1654 MLLFRSATGEAWQEIMLSCLGEK--GCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCS 1711
            + LF+  T   W  ++   L  K   C+P    P    E +     +   YFVS+I    
Sbjct: 1678 ICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISF 1737

Query: 1712 FLMLNLFVAVIMDNFEYLTRDSS-ILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTL 1770
             +++N+++AVI++NF   T +S+  L     + F  VW ++D  A   I ++++ +    
Sbjct: 1738 LVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAA 1797

Query: 1771 MSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTAL 1817
            + PPL + K  P+KV   +L+ M++P+     +H    L A  +  L
Sbjct: 1798 LDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL 1839



 Score =  151 bits (382), Expect = 6e-36
 Identities = 108/395 (27%), Positives = 190/395 (48%), Gaps = 58/395 (14%)

Query: 63  FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
           F    +L++    + +R+ + K++    F  +I+ TI+ NCI + +    P D     ++
Sbjct: 100 FNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNN--PPD----WTK 153

Query: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
            +E T   F GI+ FE+ +KI+A GF   + ++LR+ WN +DF+V++   L    T F  
Sbjct: 154 NVEYT---FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYL----TEFVN 206

Query: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
             ++  LR  RVLR LK +S IP L+ ++ ++++++  L  + +L  F + +FA+IGL+ 
Sbjct: 207 LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 266

Query: 243 YSGKLHRACFMNNSG-----------------------ILEGFDPPHPCGVQG----CPA 275
           + G L   CF N+                          LEG      CG       CP 
Sbjct: 267 FMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPE 326

Query: 276 GYEC-KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL 334
           GY C K    P+ G T FD   +A L +F+ +T + W  +   T  A G T+  ++F+ +
Sbjct: 327 GYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTY-MIFFVVV 385

Query: 335 IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVM 394
           I +GSF+++NL+L V++  + ++ +         +L  QQ ++R                
Sbjct: 386 IFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDR---------------- 429

Query: 395 LAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSD 429
           L +E + A   A       +I+RSR   ++  SS+
Sbjct: 430 LKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSE 464



 Score =  119 bits (298), Expect = 3e-26
 Identities = 88/293 (30%), Positives = 151/293 (51%), Gaps = 28/293 (9%)

Query: 458 FRHKERLLRISIRHMVKSQVFYWIVLS---------LVALNTACVAIVHHNQPQWLTHLL 508
           F HK  +   S   +   +  Y+IV+           + LNT  +A+ HH   +   ++L
Sbjct: 706 FAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVL 765

Query: 509 YYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGI 568
                +F G+F  EM LK+  M P  YF   +N FD  +   S+ E+  A        G+
Sbjct: 766 AIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE-----GL 820

Query: 569 SVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGR 628
           SVLR+ RLLR+FK+ K W +L  L+  + +S+ ++ +L  +L + + +FA++GMQLFG  
Sbjct: 821 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 880

Query: 629 F-----NFNDG--TPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAI 681
           +       ND    P  + + F  + + VF++L GE W E M++ +   G     M   +
Sbjct: 881 YKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG---QAMCLIV 936

Query: 682 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKE 734
           Y +V+ + GN  +LN+FLA+ + +  ++  LT  E E+ +A N + A+ + K+
Sbjct: 937 YMMVMVI-GNLVVLNLFLALLLSSF-SSDNLTAIE-EDPDANNLQIAVTRIKK 986



 Score =  117 bits (293), Expect = 1e-25
 Identities = 90/353 (25%), Positives = 157/353 (44%), Gaps = 76/353 (21%)

Query: 1132 SMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDY 1191
            ++++ S  +P+RR    I+    F M I+  I  + I +   +P           +  +Y
Sbjct: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPP-------DWTKNVEY 157

Query: 1192 VFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGA-LVAFALANALGTNKGRD 1250
             FTG++TFE ++K++ +G  + + ++ RD WN LDFVV+V A L  F            +
Sbjct: 158  TFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFV-----------N 206

Query: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
            +  + +LR  RVLR LKTI  +P LK +   ++ S+K + +++I+    + +FA+I +QL
Sbjct: 207  LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 266

Query: 1311 FKG-------------------------------KFFYCTDSSKDT--------EKECIG 1331
            F G                               K+FY  + SKD           +C  
Sbjct: 267  FMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPE 326

Query: 1332 NYVDHEKNKMEVK-GREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRG 1390
             Y         VK GR        +D   WA L LF + T + W  + Q ++        
Sbjct: 327  GYTC-------VKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTL-------- 371

Query: 1391 PSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNE 1443
              R+      IF+VV   +  F+ +N+ +A++ + ++EQ    +EE   ++ E
Sbjct: 372  --RAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422



 Score =  114 bits (285), Expect = 1e-24
 Identities = 75/266 (28%), Positives = 135/266 (50%), Gaps = 33/266 (12%)

Query: 1467 FQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECV 1526
            F+  ++  V+ P  +  I   I LNT+ + M+++     ++  L   N+ FT +F+ E V
Sbjct: 722  FKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMV 781

Query: 1527 LKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKL 1586
            LK+IA     YF+  WNIFD + V  S+ E+ L D +        +S L+ FR  R+ KL
Sbjct: 782  LKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE-------GLSVLRSFRLLRVFKL 834

Query: 1587 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN------IKLDEESHI 1640
             +   T+ +L+     S  AL  + L++A++ FI+A++GMQ+FG        K++++  +
Sbjct: 835  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 894

Query: 1641 NRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAY 1700
             R  +   FF S +++FR   GE W E M  C+                  E  G  +  
Sbjct: 895  PRW-HMNDFFHSFLIVFRVLCGE-WIETMWDCM------------------EVAGQAMCL 934

Query: 1701 VYFVSFIFFCSFLMLNLFVAVIMDNF 1726
            + ++  +   + ++LNLF+A+++ +F
Sbjct: 935  IVYMMVMVIGNLVVLNLFLALLLSSF 960



 Score =  114 bits (284), Expect = 1e-24
 Identities = 99/381 (25%), Positives = 179/381 (46%), Gaps = 39/381 (10%)

Query: 14   SGDGDSDQSR---NRQGT--------PVPASGQAAAYKQTKAQRARTMALYNPIPVRQ-N 61
            S D DS+ S+   NR  +        P+P  G+ A  +   +      A +    VR+ +
Sbjct: 1096 SSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPE--ACFTDGCVRRFS 1153

Query: 62   CFTVNRSLFIFGEDNI---VRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKT 118
            C  VN      G+  I   +RK   K+++   FE  I+  I+ +   LA E    E  KT
Sbjct: 1154 CCQVNIES---GKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKT 1210

Query: 119  PMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV-LSGILATAG 177
             +   LE  +  F  IF  E  +K +A G+     +Y  N W  +DF++V +S +   A 
Sbjct: 1211 -IKIILEYADKIFTYIFILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVAN 1265

Query: 178  T-HFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFA 236
            T  ++    +++LR +R LRPL+ +S    +++V+ +++ A+  ++ + L+     L+F+
Sbjct: 1266 TLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1325

Query: 237  IIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNIL 296
            I+G+  ++GK +  C     G    F          C A       +   +    FDN+ 
Sbjct: 1326 IMGVNLFAGKFYE-CINTTDG--SRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVG 1382

Query: 297  FAVLTVFQCITMEGWTTVLYNTNDALG---------ATWNWLYFIPLIIIGSFFVLNLVL 347
               L++ Q  T +GWT ++Y   D++          + + ++YF+  II GSFF LNL +
Sbjct: 1383 LGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFI 1442

Query: 348  GVLSGEFAKERERVENRRAFM 368
            GV+   F ++++++  +  FM
Sbjct: 1443 GVIIDNFNQQKKKLGGQDIFM 1463



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 72/320 (22%), Positives = 147/320 (45%), Gaps = 43/320 (13%)

Query: 465  LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
            +R +   +V+   F   ++ ++ L++  +A   ++  + + +  +L YA+ +F  +F+LE
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229

Query: 523  MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
            M LK    G + YF +++   DF +   S+  +V           I  LR LR LR  + 
Sbjct: 1230 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1289

Query: 583  TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF----NFNDGTP-- 636
               +  +R +V +L+ ++ SI+++L +  +F ++F+++G+ LF G+F    N  DG+   
Sbjct: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFP 1349

Query: 637  -------------------------SANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-- 669
                                       NFD      +++ Q+ T + W  +MY  + S  
Sbjct: 1350 ASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVN 1409

Query: 670  ---QGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDE-----QEEEE 721
               Q      ++  IYF+V  +FG++  LN+F+ + +DN    ++    +     +E+++
Sbjct: 1410 VDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKK 1469

Query: 722  AFNQKHALQKAKEVSPMSAP 741
             +N    L   K   P+  P
Sbjct: 1470 YYNAMKKLGSKKPQKPIPRP 1489



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 67/271 (24%), Positives = 129/271 (47%), Gaps = 24/271 (8%)

Query: 472  MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
            +V +Q F   ++ L+ LN   + +    Q Q +T +LY+   +F+ LF  E  LK+  + 
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559

Query: 532  PRLYFHSSFNCFDFGVTVGSIF-----EVVWAIFRPGTSFGISVLRALRLLRIFKITKYW 586
               YF   +N FDF V + SI      +++   F   T F   V+R  R+ RI ++ K  
Sbjct: 1560 -HYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLF--RVIRLARIGRILRLVKGA 1616

Query: 587  ASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAA 646
              +R L+ +LM S+ ++ ++  LLFL + ++A+ GM  F      +      NF+TF  +
Sbjct: 1617 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNS 1676

Query: 647  IMTVFQILTGEDWNEVM----------------YNGIRSQGGVSSGMWSAIYFIVLTLFG 690
            ++ +FQI T   W+ ++                + G   +G   +      YF+   +  
Sbjct: 1677 MICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIIS 1736

Query: 691  NYTLLNVFLAIAVDNLANAQELTKDEQEEEE 721
               ++N+++A+ ++N + A E + +   E++
Sbjct: 1737 FLVVVNMYIAVILENFSVATEESTEPLSEDD 1767



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 84/331 (25%), Positives = 152/331 (45%), Gaps = 53/331 (16%)

Query: 1109 EEVEKKKQKKEK---RETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAA 1165
            EE+E+ +QK      R   K ++ + S +        ++  ++IV   + ++ I + I  
Sbjct: 690  EELEESRQKCPPWWYRFAHKFLIWNCSPYWIK----FKKCIYFIVMDPFVDLAITICIVL 745

Query: 1166 SSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNIL 1225
            +++ +A E   +T   +N VL   + VFTG+F  EMV+K+I     +    YF+  WNI 
Sbjct: 746  NTLFMAMEHHPMTEEFKN-VLAIGNLVFTGIFAAEMVLKLI----AMDPYEYFQVGWNIF 800

Query: 1226 DFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTS 1285
            D ++V  +LV   LA         D++ +  LR  R+LR  K  K  P L  +   +  S
Sbjct: 801  DSLIVTLSLVELFLA---------DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 851

Query: 1286 LKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKG 1345
            +  + N+ +V  + +FIFAV+ +QLF GK +          KEC+    D          
Sbjct: 852  VGALGNLTLVLAIIVFIFAVVGMQLF-GKSY----------KECVCKIND---------- 890

Query: 1346 REWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVV 1405
             +     +H ++   + L +F V  GE W + +   ++V         + +    I Y++
Sbjct: 891  -DCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEV---------AGQAMCLIVYMM 939

Query: 1406 YFVVFPFFFVNIFVALIIITFQEQGDKMMEE 1436
              V+     +N+F+AL++ +F       +EE
Sbjct: 940  VMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 63/276 (22%), Positives = 120/276 (43%), Gaps = 52/276 (18%)

Query: 89  PPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT----EPYFIGIFCFEAGIKIV 144
           P  +  I   I+ N + +A+E H       PM+   +         F GIF  E  +K++
Sbjct: 733 PFVDLAITICIVLNTLFMAMEHH-------PMTEEFKNVLAIGNLVFTGIFAAEMVLKLI 785

Query: 145 ALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVD-LRTLRAVRVLRPLKLVSG 203
           A+        Y + GWN+ D ++V   ++      F   V+ L  LR+ R+LR  KL   
Sbjct: 786 AMD----PYEYFQVGWNIFDSLIVTLSLVEL----FLADVEGLSVLRSFRLLRVFKLAKS 837

Query: 204 IPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFD 263
            P+L +++K I  ++  L  + L+L   + +FA++G++ + GK ++ C            
Sbjct: 838 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV----------- 885

Query: 264 PPHPCGVQGCPAGYEC--KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA 321
                    C    +C    W          ++   + L VF+ +  E W   +++  + 
Sbjct: 886 ---------CKINDDCTLPRW--------HMNDFFHSFLIVFRVLCGE-WIETMWDCMEV 927

Query: 322 LGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKE 357
            G     + ++ +++IG+  VLNL L +L   F+ +
Sbjct: 928 AGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSD 963



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 89/411 (21%), Positives = 159/411 (38%), Gaps = 92/411 (22%)

Query: 464 LLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEM 523
           L RISI+ +V S +F  +++  +  N  C+ +  +N P W  ++    E+ F G++  E 
Sbjct: 115 LRRISIKILVHS-LFSMLIMCTILTN--CIFMTMNNPPDWTKNV----EYTFTGIYTFES 167

Query: 524 SLKM----YGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG-ISVLRALRLLR 578
            +K+    + +G   +    +N  DF V       +V+A      + G +S LR  R+LR
Sbjct: 168 LVKILARGFCVGEFTFLRDPWNWLDFVV-------IVFAYLTEFVNLGNVSALRTFRVLR 220

Query: 579 IFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA 638
             K       L+ +V +L+ S+K +  ++ L    + VFAL+G+QLF G         S 
Sbjct: 221 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSL 280

Query: 639 NFDTFPAAIMTVFQILTGEDWNEVMYN----------GIRSQGG---------------- 672
             +    +IM   +  + ED+ +  Y           G  +  G                
Sbjct: 281 ENNETLESIMNTLE--SEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338

Query: 673 -------------------VSSGMWSAIY--------------FIVLTLFGNYTLLNVFL 699
                              ++   W  +Y              F+V+   G++ L+N+ L
Sbjct: 339 YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLIL 398

Query: 700 AIAV-----DNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRH 754
           A+        N AN +E  + E E ++  ++    Q+  E    +A    SI R R    
Sbjct: 399 AVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGL 458

Query: 755 HMSMWEP---RSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEA 802
             S  E     S   +ERR R      ++   +L    +    E L++ E+
Sbjct: 459 SESSSETSKLSSKSAKERRNRRK----KKNQKKLSSGEEKGDAEKLSKSES 505



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 45/159 (28%), Positives = 80/159 (50%), Gaps = 13/159 (8%)

Query: 91   FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
            F+  I+  I  N + + +E+   E     M+  L      FI +F  E  +K+++L    
Sbjct: 1506 FDISIMVLICLNMVTMMVEK---EGQSQHMTEVLYWINVVFIILFTGECVLKLISL---- 1558

Query: 151  HKGSYLRNGWNVMDFIVVLSGILAT-----AGTHFNTHVDLRTLRAVRVLRPLKLVSGIP 205
             +  Y   GWN+ DF+VV+  I+         T+F +    R +R  R+ R L+LV G  
Sbjct: 1559 -RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAK 1617

Query: 206  SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYS 244
             ++ +L ++M ++  L  IGLLLF  + ++AI G+  ++
Sbjct: 1618 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 45/164 (27%), Positives = 82/164 (50%), Gaps = 19/164 (11%)

Query: 1475 VVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGF 1534
            +V   F   IM  I  N + + M   + P  +   ++Y    FT +++ E ++K++A GF
Sbjct: 123  LVHSLFSMLIMCTILTNCIFMTM---NNPPDWTKNVEY---TFTGIYTFESLVKILARGF 176

Query: 1535 ----LNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQG 1590
                  + RD WN  DF+ ++ +        ++ VN    N+S L+ FR  R +K +   
Sbjct: 177  CVGEFTFLRDPWNWLDFVVIVFAYL------TEFVNLG--NVSALRTFRVLRALKTISVI 228

Query: 1591 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIK 1633
              ++ ++   +QS K L  V +L      ++A+IG+Q+F GN+K
Sbjct: 229  PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,863,353
Number of Sequences: 37866
Number of extensions: 3953111
Number of successful extensions: 27114
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 387
Number of HSP's that attempted gapping in prelim test: 19355
Number of HSP's gapped (non-prelim): 4425
length of query: 2270
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2152
effective length of database: 13,779,330
effective search space: 29653118160
effective search space used: 29653118160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.