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Search of human proteins with 5174673
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174673 semaphorin 3A precursor [Homo sapiens]
(771 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174673 semaphorin 3A precursor [Homo sapiens] 1622 0.0
gi|41406086 semaphorin 3D [Homo sapiens] 862 0.0
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 805 0.0
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 800 0.0
gi|6912650 semaphorin 3E [Homo sapiens] 786 0.0
gi|188497703 semaphorin 3F [Homo sapiens] 736 0.0
gi|5454048 semaphorin 3C [Homo sapiens] 708 0.0
gi|9910362 semaphorin sem2 [Homo sapiens] 699 0.0
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 360 4e-99
gi|157388902 semaphorin 4C [Homo sapiens] 355 1e-97
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 342 8e-94
gi|28872814 semaphorin 4G [Homo sapiens] 339 7e-93
gi|39777610 semaphorin 4B precursor [Homo sapiens] 324 2e-88
gi|39777608 semaphorin 4B precursor [Homo sapiens] 324 2e-88
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 313 4e-85
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 305 1e-82
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 305 1e-82
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 303 4e-82
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 303 4e-82
gi|21361914 semaphorin B [Homo sapiens] 301 2e-81
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 299 7e-81
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 286 4e-77
gi|16306552 semaphorin Y [Homo sapiens] 279 8e-75
gi|19923279 semaphorin W [Homo sapiens] 270 4e-72
gi|147904700 semaphorin 5A [Homo sapiens] 266 5e-71
gi|19718780 semaphorin 6B precursor [Homo sapiens] 263 6e-70
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 262 8e-70
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 228 2e-59
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 226 5e-59
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 207 3e-53
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 1622 bits (4201), Expect = 0.0
Identities = 771/771 (100%), Positives = 771/771 (100%)
Query: 1 MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTF 60
MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTF
Sbjct: 1 MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTF 60
Query: 61 LLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
LLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV
Sbjct: 61 LLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASL 180
LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASL
Sbjct: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASL 180
Query: 181 LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED 240
LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED
Sbjct: 181 LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED 240
Query: 241 DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG 300
DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG
Sbjct: 241 DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG 300
Query: 301 IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD 360
IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD
Sbjct: 301 IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD 360
Query: 361 GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP 420
GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP
Sbjct: 361 GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP 420
Query: 421 IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM 480
IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM
Sbjct: 421 IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM 480
Query: 481 TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS 540
TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS
Sbjct: 481 TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS 540
Query: 541 ACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPK 600
ACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPK
Sbjct: 541 ACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPK 600
Query: 601 SQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTL 660
SQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTL
Sbjct: 601 SQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTL 660
Query: 661 LKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE 720
LKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE
Sbjct: 661 LKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE 720
Query: 721 FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV 771
FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV
Sbjct: 721 FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV 771
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 862 bits (2227), Expect = 0.0
Identities = 414/752 (55%), Positives = 556/752 (73%), Gaps = 21/752 (2%)
Query: 26 KNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNI 85
K N+PRLKL+YK++L SN+ I F G + + T LLDEER RL +GAKDHIF LV++
Sbjct: 39 KQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDL 98
Query: 86 -KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYI 144
K+F+KI WP + R + CK AGKD ECANFI+VL+ YN+TH+Y CGTGAFHPIC YI
Sbjct: 99 NKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYI 158
Query: 145 EIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRT 204
++G + ED IFKL+ + E+GR K P+DP+ AS++ D LYSGTA+DF+G+D A R+
Sbjct: 159 DLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRS 218
Query: 205 LG---HHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKAT 261
LG HH IRT+ + WLN KFI I ++ NP+DDK+YFFFRE++ +G S K
Sbjct: 219 LGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTI 278
Query: 262 HARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKN 321
+R+G++CKND GG RSL+NKWTTFLKARLICS+PG +G DT+FDELQD++L+ +D +N
Sbjct: 279 LSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERN 338
Query: 322 PVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTC 381
PVVYGVFTT+S+IFKGSAVC+YSM+D+R VF GPYAH++ +++WV Y GR+PYPRPGTC
Sbjct: 339 PVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTC 398
Query: 382 PSKTFGG-FDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVD 440
PSKT+ ST+D PDDVI+F + H MY V+P+ P + +V+Y+ TQIVVD V
Sbjct: 399 PSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVI 458
Query: 441 AEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQ 500
AEDGQYDVMF+GTD+GTVLKVVSI KE W ++EEV+LEE+ +F+ + I MELS KQQQ
Sbjct: 459 AEDGQYDVMFLGTDIGTVLKVVSISKEKW-NMEEVVLEELQIFKHSSIILNMELSLKQQQ 517
Query: 501 LYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRN 560
LYIGS G+ QL LHRCD YGKACA+CCLARDPYCAWDG+ACSRY PT+KRR RRQD++
Sbjct: 518 LYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKY 577
Query: 561 GDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEE 620
GDP+T C D+ H + +E++I+G+E +STFLEC PKSQ+A + W QR +E +EE
Sbjct: 578 GDPITQCWDIEDSISH-ETADEKVIFGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREE 636
Query: 621 IRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKD 680
++ D+ II+T+ GLL+RSLQ+KDSG Y C A EH FI T++K+TL VI+ E +E +
Sbjct: 637 LKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAE 696
Query: 681 DDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHT 740
+ K K+ + ++ Y+D++Q+++ PN ++D++CEQ+W R+++++R + G
Sbjct: 697 H--EEGKVKD----LLAESRLRYKDYIQILSSPNF-SLDQYCEQMWHREKRRQRNKGG-- 747
Query: 741 PGNSNKWKHLQENKKGRNRRTH-EFERAPRSV 771
KWKH+QE KK RNRR H + + PR+V
Sbjct: 748 ----PKWKHMQEMKKKRNRRHHRDLDELPRAV 775
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 805 bits (2079), Expect = 0.0
Identities = 401/769 (52%), Positives = 529/769 (68%), Gaps = 42/769 (5%)
Query: 8 VCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERS 67
+ L W V L + A + PRL+LS++E+ + + TF+ L + Y L+DEER
Sbjct: 13 LALLWAVGLGSAAP------SPPRLRLSFQELQAWHGLQTFS-LERTCCYQALLVDEERG 65
Query: 68 RLYVGAKDHIFSFDLVNI-KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQ 126
RL+VGA++H+ S +L NI K +K+ WP R+EC WAGKDI EC NF+K+L AYN+
Sbjct: 66 RLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNR 125
Query: 127 THLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGEL 186
THL ACGTGAFHP C ++E+GH E+ + +L+ E+G+GKSPYDP+ AS+L+ EL
Sbjct: 126 THLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
Query: 187 YSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFF 246
YSG AAD MGRDF IFR+LG +RTE HDSRWLN+PKF+ I ES+NP+DDK+YFF
Sbjct: 186 YSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFF 245
Query: 247 FRENAIDGEHS-GKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHF 305
FRE A++ + G+ + +R+GQIC+ND GG RSLVNKWTTFLKARL+CSVPG G DTHF
Sbjct: 246 FRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHF 304
Query: 306 DELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQ 365
D+LQDVFL++ +D + P++Y VF+TSS+IF+GSAVC+YSM+DVRR FLGP+AH++GP +Q
Sbjct: 305 DQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQ 364
Query: 366 WVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKT 425
WV YQGRVPYPRPG CPSKTFG F STKD PDDVI FAR+HP MYN V P RP+ ++
Sbjct: 365 WVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 424
Query: 426 DVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFRE 485
NY FTQI DRV A DG YDV+FIGTDVGTVLKV+S+PK + E +LLEE+ VF +
Sbjct: 425 GANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED 484
Query: 486 PTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRY 545
A+++M++S+K+ QLY+ S + VAQ+ LHRC +G+ C ECCLARDPYCAWDG AC+R+
Sbjct: 485 SAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRF 544
Query: 546 FPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRAL 605
P+AKRR RRQD+RNGDP T CS D+ E + ++GVE SS FLEC P+S +A
Sbjct: 545 QPSAKRRFRRQDVRNGDPSTLCSG---DSSRPALLEHK-VFGVEGSSAFLECEPRSLQAR 600
Query: 606 VYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTL 665
V W FQR ++ ++ RT +GLLLR L+++DSG YLC AVE GF Q L +++L
Sbjct: 601 VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL 660
Query: 666 EVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQV 725
V+ E L ++ +E + + P K+WYRDF+QL+ + +
Sbjct: 661 HVLSATQAERL---------ARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSL---- 707
Query: 726 WKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTH----EFERAPRS 770
+ R +P + + L+ +KGRNRRTH ER PRS
Sbjct: 708 -----RMCRPQP------ALQSLPLESRRKGRNRRTHAPEPRAERGPRS 745
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 800 bits (2066), Expect = 0.0
Identities = 401/769 (52%), Positives = 528/769 (68%), Gaps = 43/769 (5%)
Query: 8 VCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERS 67
+ L W V L + A + PRL+LS++E+ + + TF+ L + Y L+DEER
Sbjct: 13 LALLWAVGLGSAAP------SPPRLRLSFQELQAWHGLQTFS-LERTCCYQALLVDEERG 65
Query: 68 RLYVGAKDHIFSFDLVNI-KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQ 126
RL+VGA++H+ S +L NI K +K+ WP R+EC WAGKDI EC NF+K+L AYN+
Sbjct: 66 RLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNR 125
Query: 127 THLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGEL 186
THL ACGTGAFHP C ++E+GH E+ + +L+ E+G+GKSPYDP+ AS+L+ EL
Sbjct: 126 THLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEEL 185
Query: 187 YSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFF 246
YSG AAD MGRDF IFR+LG +RTE HDSRWLN+PKF+ I ES+NP+DDK+YFF
Sbjct: 186 YSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFF 245
Query: 247 FRENAIDGEHS-GKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHF 305
FRE A++ + G+ + +R+GQIC+ND GG RSLVNKWTTFLKARL+CSVPG G DTHF
Sbjct: 246 FRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHF 304
Query: 306 DELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQ 365
D+LQDVFL++ +D + P++Y VF+TSS IF+GSAVC+YSM+DVRR FLGP+AH++GP +Q
Sbjct: 305 DQLQDVFLLSSRDHRTPLLYAVFSTSS-IFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQ 363
Query: 366 WVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKT 425
WV YQGRVPYPRPG CPSKTFG F STKD PDDVI FAR+HP MYN V P RP+ ++
Sbjct: 364 WVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 423
Query: 426 DVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFRE 485
NY FTQI DRV A DG YDV+FIGTDVGTVLKV+S+PK + E +LLEE+ VF +
Sbjct: 424 GANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFED 483
Query: 486 PTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRY 545
A+++M++S+K+ QLY+ S + VAQ+ LHRC +G+ C ECCLARDPYCAWDG AC+R+
Sbjct: 484 SAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRF 543
Query: 546 FPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRAL 605
P+AKRR RRQD+RNGDP T CS D+ E + ++GVE SS FLEC P+S +A
Sbjct: 544 QPSAKRRFRRQDVRNGDPSTLCSG---DSSRPALLEHK-VFGVEGSSAFLECEPRSLQAR 599
Query: 606 VYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTL 665
V W FQR ++ ++ RT +GLLLR L+++DSG YLC AVE GF Q L +++L
Sbjct: 600 VEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSL 659
Query: 666 EVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQV 725
V+ E L ++ +E + + P K+WYRDF+QL+ + +
Sbjct: 660 HVLSATQAERL---------ARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSL---- 706
Query: 726 WKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTH----EFERAPRS 770
+ R +P + + L+ +KGRNRRTH ER PRS
Sbjct: 707 -----RMCRPQP------ALQSLPLESRRKGRNRRTHAPEPRAERGPRS 744
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 786 bits (2029), Expect = 0.0
Identities = 373/770 (48%), Positives = 519/770 (67%), Gaps = 14/770 (1%)
Query: 7 IVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER 66
I L WG LL PRL+LS+KE+L N F+ HT LLDE +
Sbjct: 8 ITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQ 67
Query: 67 SRLYVGAKDHIFSFDLVNIKD-FQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYN 125
RL+VG +D ++S L I D +++I WP + + +EC GKD ECAN+++VL YN
Sbjct: 68 ERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDA-GECANYVRVLHHYN 126
Query: 126 QTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGE 185
+THL CGTGAF P+C +I +G+H ED +F LE+ E GRG+ P+DP S LI E
Sbjct: 127 RTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSE 186
Query: 186 LYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYF 245
L++G +D+ RD AIFR++G IRTE D R L +PKF+ +++I ++++ +D+KVYF
Sbjct: 187 LFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYF 246
Query: 246 FFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHF 305
FF E A++ E++ A + R+G++C ND GG R LVNKW+TFLKARL+CSVPG NGIDT+F
Sbjct: 247 FFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYF 306
Query: 306 DELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQ 365
DEL+DVFL+ +D KNPV++G+F T+SNIF+G A+C+Y MS +R F GPYAH++GP Y
Sbjct: 307 DELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYH 366
Query: 366 WVPYQGRVPYPRPGTCPSKTFGG-FDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIK 424
W Y+G+VPYPRPG+C SK GG + +TKD PDD I FARSHP MY + P + +PI++K
Sbjct: 367 WSVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVK 426
Query: 425 TDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFR 484
TD Y QI VDRV+AEDGQYDV+FIGTD G VLKV++I + +EEV+LEE+ +F+
Sbjct: 427 TDGKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFK 486
Query: 485 EPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSR 544
+P I +ME+S+K+QQLYIGS + VAQ+ H CD+YG ACA+CCLARDPYCAWDG +CSR
Sbjct: 487 DPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSR 546
Query: 545 YFPT---AKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKS 601
Y+PT AKRR RRQD+R+G+ C EE + YG+EN+ST LEC+P+S
Sbjct: 547 YYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRS 606
Query: 602 QRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLL 661
+A V W Q+ E RKEE++ DD +++ D GLL L + D+G Y C VEH F+ T+
Sbjct: 607 LQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVR 666
Query: 662 KVTLEVIDTEHLEELLHKDDDGDGSKTK--EMSNSMTPSQKVWYRDFMQLINHPNLNTMD 719
K+TLEV++ E +E++ +KDD+ D +S++ K WY++F+QLI + N ++
Sbjct: 667 KITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVE 726
Query: 720 EFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPR 769
E+CE+VW DRK+++ + + +KWK+ +K + R E R PR
Sbjct: 727 EYCEKVWCTDRKRKKLKM-----SPSKWKYANPQEK-KLRSKPEHYRLPR 770
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 736 bits (1901), Expect = 0.0
Identities = 369/789 (46%), Positives = 502/789 (63%), Gaps = 50/789 (6%)
Query: 10 LFWGVLLTAR---ANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER 66
L W LLT Q+ PR++LS+KE+ + FN L N++ Y L DE+
Sbjct: 7 LLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDH 66
Query: 67 SRLYVGAKDHIFSFDLVNIKDFQKIV-WPVSYTRRDECKWAGKDILKECANFIKVLKAYN 125
R+YVG+KD++ S DL +I I+ W S R +EC +GKD+ EC NF+++++ +N
Sbjct: 67 DRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWN 126
Query: 126 QTHLYACGTGAFHPICTYIEIGHHPE-------------------------------DNI 154
+THLY CGTGA++P+CTY+ G + D I
Sbjct: 127 RTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYI 186
Query: 155 FKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTE 214
F LE E+G+GK PYDPKL TAS LI+ ELY+G DFMG D AIFRTLG +RT+
Sbjct: 187 FYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTD 246
Query: 215 QHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFG 274
Q++SRWLNDP FI A LI +S DDK+YFFFRE + + S A +ARIG+IC ND G
Sbjct: 247 QYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQS-PAVYARIGRICLNDDG 305
Query: 275 GHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNI 334
GH LVNKW+TFLKARL+CSVPG +GI+THFDELQDVF+ +D +NPV+Y VFT+S ++
Sbjct: 306 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSV 365
Query: 335 FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTF-GGFDSTK 393
F+GSAVC+YSM+D+R VF GP+AH++GPNYQW+P+ G++PYPRPGTCP TF STK
Sbjct: 366 FRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTK 425
Query: 394 DLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGT 453
D PD+VI F RSHP MY V+P+ RP+V++T Y+ T I VD+VDA DG+Y+V+F+GT
Sbjct: 426 DYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGT 485
Query: 454 DVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLP 513
D GTV KV+ +PK+ +LEE++LEE+ VF++P + M +S+K+QQLY+ S GV L
Sbjct: 486 DRGTVQKVIVLPKDD-QELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLS 544
Query: 514 LHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHD 573
LHRC YG ACA+CCLARDPYCAWDG ACSRY ++KRR+RRQD+R+G+P+ C +
Sbjct: 545 LHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGF--N 602
Query: 574 NHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQG 633
++ + E + YGV S+ FLEC P+S +A V W FQR +R+ EIR +D +RT+QG
Sbjct: 603 SNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQG 662
Query: 634 LLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSN 693
LLLR+LQ D G Y C A E+ F + +V L V+ + + L
Sbjct: 663 LLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGAGP 722
Query: 694 SMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQEN 753
P Y++ QL+ P + + ++C+ W+ R+ PG + + Q+
Sbjct: 723 PTPP-----YQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPG-----APRSPEPQDQ 772
Query: 754 KKGRNRRTH 762
KK RNRR H
Sbjct: 773 KKPRNRRHH 781
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 708 bits (1827), Expect = 0.0
Identities = 339/757 (44%), Positives = 508/757 (67%), Gaps = 17/757 (2%)
Query: 6 RIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEE 65
R +C+ GV + + + R+ L++ E+ E+ F+ + Y L+DE+
Sbjct: 4 RTICVLVGVFICSIC-VKGSSQPQARVYLTFDELRETKTSEYFSLSHHPLDYRILLMDED 62
Query: 66 RSRLYVGAKDHIFSFDLVNI-KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAY 124
+ R+YVG+KDHI S ++ NI ++ + WP S + +ECK AGKD C NF++V++ +
Sbjct: 63 QDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTF 122
Query: 125 NQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDG 184
N+THLY CG+GAF P+CTY+ G ED +F ++ S E+G+G+ ++P + T S++I+
Sbjct: 123 NRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMID-SKCESGKGRCSFNPNVNTVSVMINE 181
Query: 185 ELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVY 244
EL+SG DFMG D AIFR+L + +RT+QH+S+WL++P F+ AH+I + +P D KVY
Sbjct: 182 ELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVY 241
Query: 245 FFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTH 304
FFF+E D S K H+ I +IC ND GG RSLVNKWTTFLKARL+CSV +G +TH
Sbjct: 242 FFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETH 301
Query: 305 FDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNY 364
FDEL+DVFL+ +P+ +VYG+FTTSS++FKGSAVC+Y +SD++ VF GP+AH++GPN+
Sbjct: 302 FDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNH 361
Query: 365 QWVPYQGRVPYPRPGTCPSKTF-GGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVI 423
Q + YQGR+PYPRPGTCP F +TK+ PDDV+TF R+HP MYN ++P++ RP+++
Sbjct: 362 QLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIV 421
Query: 424 KTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVF 483
+ +Y++T+I VDRV+A DG+Y V+F+GTD GTV KVV +P E++LEE+ VF
Sbjct: 422 RIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSVS-GELILEELEVF 480
Query: 484 REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACS 543
+ I+ M++S+K+QQLY+ S GV+Q+ LHRC IYG ACA+CCLARDPYCAWDG +CS
Sbjct: 481 KNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCS 540
Query: 544 RYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQR 603
R++PT KRR+RRQD+R+G+PLT C + + + E + YGV+N++TFLEC+PKS +
Sbjct: 541 RFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAY--RNAAEIVQYGVKNNTTFLECAPKSPQ 598
Query: 604 ALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKV 663
A + W Q ++++R++E+++++ II T QGLL+RS+Q D G Y C A E+ F QT+ K+
Sbjct: 599 ASIKWLLQ-KDKDRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTIAKI 657
Query: 664 TLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDEFCE 723
+V+D+E + + K + S + +D M +H + ++++C+
Sbjct: 658 NFKVLDSEMVAVVTDKWSPWTWA-------SSVRALPFHPKDIMGAFSHSEMQMINQYCK 710
Query: 724 QVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRR 760
R + Q+ G+ K K L ++K RNRR
Sbjct: 711 DT--RQQHQQGDESQKMRGDYGKLKALINSRKSRNRR 745
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 699 bits (1804), Expect = 0.0
Identities = 358/776 (46%), Positives = 497/776 (64%), Gaps = 15/776 (1%)
Query: 7 IVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER 66
I L G+LL ++ + +VPRL+LSY+++L +N F G S + LDE R
Sbjct: 8 ICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYR 67
Query: 67 SRLYVGAKDHIFSFDLVNI-KDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYN 125
RL++G D ++S L D ++++WP +R+EC G+D L ECANF++VL+ +N
Sbjct: 68 DRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHN 127
Query: 126 QTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGE 185
+THL ACGTGAF P C I +GH E ++ LE E+GRG+ P++P AS IDGE
Sbjct: 128 RTHLLACGTGAFQPTCALITVGHRGE-HVLHLEPGSVESGRGRCPHEPSRPFASTFIDGE 186
Query: 186 LYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYF 245
LY+G ADF+GR+ IFR+ G +R++ D L+DP+F+ A I E+ + ++DKVYF
Sbjct: 187 LYTGLTADFLGREAMIFRSGGPRPALRSDS-DQSLLHDPRFVMAARIPENSDQDNDKVYF 245
Query: 246 FFRENAIDGEH-SGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTH 304
FF E + S T +R+G++C ND GG R LVNKW+TFLKARL+CSVPGP G +TH
Sbjct: 246 FFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETH 305
Query: 305 FDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNY 364
FD+L+DVFL+ K K+ VY +F+T S +F+G AVC+Y M+D+ VF GP+AHRDGP +
Sbjct: 306 FDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQH 365
Query: 365 QWVPYQGRVPYPRPGTCPSKTFG----GFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP 420
QW PY G+VP+PRPG CPSK F STKD PD+V+ FAR+HP M+ PV P + RP
Sbjct: 366 QWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRP 425
Query: 421 IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM 480
+++KT + Q QIVVDRV+AEDG YDV+F+GTD G+VLKV+++ + EEV+LEE+
Sbjct: 426 VLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEEL 485
Query: 481 TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS 540
VF+ PT I+ ME+S K+Q LY+GS GVAQL LH+C+ YG ACAECCLARDPYCAWDG+
Sbjct: 486 QVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGA 545
Query: 541 ACSRYFPT-AKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSP 599
+C+ Y P+ KRR RRQDIR+G+P C + ++YG E++STFLEC P
Sbjct: 546 SCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLP 605
Query: 600 KSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQT 659
KS +A V W QR +E ++++ D+ ++ T++GLL R L + D+G Y C +EHGF QT
Sbjct: 606 KSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQT 665
Query: 660 LLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMD 719
++++ L VI L+ L + + + S P K WY+D +QLI NL +D
Sbjct: 666 VVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPP--KAWYKDILQLIGFANLPRVD 723
Query: 720 EFCEQVWKRDRKQ----RRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV 771
E+CE+VW R + R R W L+ KK ++R E R PR V
Sbjct: 724 EYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREV 779
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 360 bits (923), Expect = 4e-99
Identities = 236/650 (36%), Positives = 355/650 (54%), Gaps = 53/650 (8%)
Query: 29 VPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDF 88
+PR+ ++E+ +++ F+ + +Y LL E++ LY+GA++ +F+ + +NI +
Sbjct: 27 IPRITWEHREV----HLVQFHE-PDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEK 81
Query: 89 Q-KIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIG 147
Q ++ W VS ++ +C GK EC N+I+VL+ + T LY CGT AF P C ++ +
Sbjct: 82 QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNL- 140
Query: 148 HHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGH 207
FK + E+G+G+ P+DP S+++DGELYSGT+ +F+G + I R
Sbjct: 141 -----TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SS 193
Query: 208 HHPIRTEQHDSRWLNDPKFISAHLISES-DNP--EDDKVYFFFRENAIDGEHSGKATHAR 264
H P+RTE + WLN+P F+ A +I +S D+P EDD+VYFFF E +++ E + R
Sbjct: 194 HSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPR 252
Query: 265 IGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVV 324
I ++CK D GG R+L KWT+FLKARLICS P + F+ L+DVF++ K PV
Sbjct: 253 IARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVF 309
Query: 325 YGVFTTSSNIFKGSAVCMYSMSDVRRVFL-GPYAHR---DGPNYQWVPYQGRVPYPRPGT 380
Y +FT N SAVC Y++S VF G Y + + +WV Y G VP PRPG
Sbjct: 310 YALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGA 369
Query: 381 C--PSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDR 438
C + S+ +LPD + F + HP M + V P++NRP +IK DVNY TQIVVDR
Sbjct: 370 CIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDR 427
Query: 439 VDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTK 497
A DG YDVMF+ TD G + K +S+ ++EE +F++ + + LS+K
Sbjct: 428 TQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSK 481
Query: 498 Q--QQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWD--GSACSRYFPTAKRRT 553
+ + +Y GS +GV Q PL C +G C +C LARDPYCAW + C T
Sbjct: 482 KGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540
Query: 554 RRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRR 613
+GD + C D ++ H + + L+CS KS A V+W+FQ
Sbjct: 541 GLIQEMSGD-ASVCPDKSKGSYRQH-------FFKHGGTAELKCSQKSNLARVFWKFQ-- 590
Query: 614 NEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKV 663
N K E + + + LL+ +L + DSG Y C + E +T+ +V
Sbjct: 591 NGVLKAE--SPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQV 638
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 355 bits (910), Expect = 1e-97
Identities = 235/667 (35%), Positives = 343/667 (51%), Gaps = 55/667 (8%)
Query: 3 WLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLL 62
WL + WG+ + A + N VPR +S E+ + G+ + + T L
Sbjct: 8 WL--LAARLWGLGIGAEVWW----NLVPRKTVSSGELATVVRRFSQTGIQD---FLTLTL 58
Query: 63 DEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLK 122
E LYVGA++ +F+F + ++ I W ++ EC GK+ EC NFI+ L+
Sbjct: 59 TEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQ 118
Query: 123 AYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLI 182
YN +HLY CGT AF P CTY+ + F LE+ FE+G+GK PYDP A LL+
Sbjct: 119 PYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLV 172
Query: 183 DGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNP---E 239
DGELYS T +F+G + I R +G HH ++TE + + WLN+P F+ + + ES +
Sbjct: 173 DGELYSATLNNFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGD 231
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPN 299
DDKVYFFFRE A++ + + AR+ ++CK D GG R+L KWTTFLKARL CS P
Sbjct: 232 DDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP--- 288
Query: 300 GIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHR 359
+F++LQ + + N +GVF SA+C Y + +++RVF GPY
Sbjct: 289 NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEY 348
Query: 360 DGPNYQWVPYQGRVPYPRPGTCPSKTF--GGFDSTKDLPDDVITFARSHPAMYNPVFPMN 417
+W Y VP PRPG+C + G+ S+ +LPD+++ F + HP M V P
Sbjct: 349 HEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRW 408
Query: 418 NRPIVIKTDVNYQFTQIVVDRVDAEDG-QYDVMFIGTDVGTVLKVVSIPKETWYDLEEVL 476
+RP+++K N FT +V DRV DG Y V+FIGT G +LK VS+ W L
Sbjct: 409 SRPLLVKKGTN--FTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSL--GPWVH----L 460
Query: 477 LEEMTVF-REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYC 535
+EE+ +F +EP + ++ LS ++ L+ GS + + QLP+ C Y ++CA+C LARDPYC
Sbjct: 461 IEELQLFDQEP--MRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYC 517
Query: 536 AWDGSACSRYFPTAKRRTRR--QDIRNGDPLTHCSDLHHDNHHGHS---PEERIIYGVEN 590
AW + SR Q + D C N G P + I V
Sbjct: 518 AWSVNT-SRCVAVGGHSGSLLIQHVMTSDTSGIC------NLRGSKKVRPTPKNITVVAG 570
Query: 591 SSTFLECSPKSQRALVYWQFQRRN--EERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYL 648
+ L C S A W F R+ E+ D + Q L++ + Q + +G Y
Sbjct: 571 TDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARL----QALVVMAAQPRHAGAYH 626
Query: 649 CHAVEHG 655
C + E G
Sbjct: 627 CFSEEQG 633
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 342 bits (877), Expect = 8e-94
Identities = 205/522 (39%), Positives = 304/522 (58%), Gaps = 39/522 (7%)
Query: 29 VPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDF 88
+PR+ ++E+ +++ F+ + +Y LL E++ LY+GA++ +F+ + +NI +
Sbjct: 27 IPRITWEHREV----HLVQFHE-PDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEK 81
Query: 89 Q-KIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIG 147
Q ++ W VS ++ +C GK EC N+I+VL+ + T LY CGT AF P C ++ +
Sbjct: 82 QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNL- 140
Query: 148 HHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGH 207
FK + E+G+G+ P+DP S+++DGELYSGT+ +F+G + I R
Sbjct: 141 -----TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SS 193
Query: 208 HHPIRTEQHDSRWLNDPKFISAHLISES-DNP--EDDKVYFFFRENAIDGEHSGKATHAR 264
H P+RTE + WLN+P F+ A +I +S D+P EDD+VYFFF E +++ E + R
Sbjct: 194 HSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPR 252
Query: 265 IGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVV 324
I ++CK D GG R+L KWT+FLKARLICS P + F+ L+DVF++ K PV
Sbjct: 253 IARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVF 309
Query: 325 YGVFTTSSNIFKGSAVCMYSMSDVRRVFL-GPYAHR---DGPNYQWVPYQGRVPYPRPGT 380
Y +FT N SAVC Y++S VF G Y + + +WV Y G VP PRPG
Sbjct: 310 YALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGA 369
Query: 381 C--PSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDR 438
C + S+ +LPD + F + HP M + V P++NRP +IK DVNY TQIVVDR
Sbjct: 370 CIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDR 427
Query: 439 VDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTK 497
A DG YDVMF+ TD G + K +S+ ++EE +F++ + + LS+K
Sbjct: 428 TQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSK 481
Query: 498 Q--QQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAW 537
+ + +Y GS +GV Q PL C +G C +C LARDPYCAW
Sbjct: 482 KGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW 522
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 339 bits (869), Expect = 7e-93
Identities = 230/666 (34%), Positives = 330/666 (49%), Gaps = 72/666 (10%)
Query: 30 PRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKD-- 87
PR+ + Y+E+ + + F G A + Y T LL+E +RL VGA+ +FS +I D
Sbjct: 34 PRMTIPYEELSGTRH---FKGQAQN--YSTLLLEEASARLLVGARGALFSLSANDIGDGA 88
Query: 88 FQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIG 147
++I W S + +C GK+ EC N ++ L+ N THLYACGT AF P+C I+
Sbjct: 89 HKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDA- 147
Query: 148 HHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGH 207
F L S FE G+ K PYDP L+IDG LY+ T +F R R H
Sbjct: 148 -----EAFTLPTS-FEEGKEKCPYDPARGFTGLIIDGGLYTATRYEF--RSIPDIRRSRH 199
Query: 208 HHPIRTEQHDSRWLNDPKFISAHLISESDNP---EDDKVYFFFRENAIDGEHSGKATH-- 262
H +RTE+ WLND +F+ + L+ ES +DDKVY+FF E A + E SG T
Sbjct: 200 PHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATE-EGSGSFTQSR 258
Query: 263 -----ARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFK 317
AR+ ++CK D GG + L KWT+FLKARLIC +P ++ L+ V ++ +
Sbjct: 259 SSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-------LYETLRGVCSLDAE 311
Query: 318 DPKNPVVYGVFTTSS--NIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPY 375
Y FT S+ + SA+C Y +++++ VF GPY + +W Y+G VP
Sbjct: 312 TSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPE 371
Query: 376 PRPGTC--PSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQ 433
PRPG+C S G++S++DLP V+ F + HP M PV P RP+++K ++ Y T
Sbjct: 372 PRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRY--TH 429
Query: 434 IVVDRVDAEDG-QYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAM 492
+ V G YD++F+GT G + K V + ++EE VFRE ++ +
Sbjct: 430 LTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSGMH------IIEETQVFRESQSVENL 483
Query: 493 ELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS--ACSRYFPTAK 550
+S Q LY+G+ +GV QLPL C Y ++C +C LARDPYC WD AC+ A
Sbjct: 484 VISLLQHSLYVGAPSGVIQLPLSSCSRY-RSCYDCILARDPYCGWDPGTHACAAATTIAN 542
Query: 551 R----RTRR-QDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRAL 605
R RT QDI G+ G P + + L C S A
Sbjct: 543 RSQGSRTALIQDIERGN-----RGCESSRDTGPPPPLKTRSVLRGDDVLLPCDQPSNLAR 597
Query: 606 VYW----QFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLL 661
W + + + VD GLL+ Q + SGNY C+A E+G L
Sbjct: 598 ALWLLNGSMGLSDGQGGYRVGVD--------GLLVTDAQPEHSGNYGCYAEENGLRTLLA 649
Query: 662 KVTLEV 667
+L V
Sbjct: 650 SYSLTV 655
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 324 bits (831), Expect = 2e-88
Identities = 215/636 (33%), Positives = 324/636 (50%), Gaps = 48/636 (7%)
Query: 55 SSYHTFLLDEERSRLYVGAKDHIFSFDLVNIK-----DFQKIVWPVSYTRRDECKWAGKD 109
S+Y LL + LYVGA++ +F+ N+ ++Q+++W ++ +C + GKD
Sbjct: 68 SNYTALLLSRDGRTLYVGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKD 126
Query: 110 ILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKS 169
++C N+IK+L + +HL+ CGT AF P+CTYI + + K N E+G+G+
Sbjct: 127 PQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEK-GNVLLEDGKGRC 185
Query: 170 PYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISA 229
P+DP + +L++DGELY+GT + F G D AI R+ P +TE WL DP F+++
Sbjct: 186 PFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTES-SLNWLQDPAFVAS 243
Query: 230 HLISESDNP---EDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTF 286
I ES +DDK+YFFF E + E +RI +ICK D GG R L +WT+F
Sbjct: 244 AYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSF 303
Query: 287 LKARLICSVPGPNGIDTHFDELQDVFLM--NFKDPKNPVVYGVFTTS--SNIFKGSAVCM 342
LKA+L+CS P F+ LQDVF + + +D ++ + YGVFT+ +GSAVC+
Sbjct: 304 LKAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
Query: 343 YSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTC--PSKTFGGFDSTKDLPDDVI 400
++M DV+RVF G Y + QW VP PRPG C S +S+ LPD V+
Sbjct: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
Query: 401 TFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLK 460
F + H M V +R ++++ YQ ++ V RV YDV+F+GT G + K
Sbjct: 421 NFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
Query: 461 VVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIY 520
VS+ ++EE+ +F + + L T + LY S +GV Q+P+ C +Y
Sbjct: 476 AVSVGPRVH------IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY 529
Query: 521 GKACAECCLARDPYCAWDGSAC---SRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHH- 576
++C +C LARDPYCAW GS+C S Y P R QDI CS +
Sbjct: 530 -RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSF 588
Query: 577 ---GHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQG 633
G P E++ + N+ L C S A W H++ T
Sbjct: 589 VPTGEKPCEQVQF-QPNTVNTLACPLLSNLATRLW----LRNGAPVNASASCHVLPTGDL 643
Query: 634 LLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVID 669
LL+ + Q G + C ++E GF Q + EV++
Sbjct: 644 LLVGTQQ---LGEFQCWSLEEGFQQLVASYCPEVVE 676
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 324 bits (831), Expect = 2e-88
Identities = 215/636 (33%), Positives = 324/636 (50%), Gaps = 48/636 (7%)
Query: 55 SSYHTFLLDEERSRLYVGAKDHIFSFDLVNIK-----DFQKIVWPVSYTRRDECKWAGKD 109
S+Y LL + LYVGA++ +F+ N+ ++Q+++W ++ +C + GKD
Sbjct: 68 SNYTALLLSRDGRTLYVGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKD 126
Query: 110 ILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKS 169
++C N+IK+L + +HL+ CGT AF P+CTYI + + K N E+G+G+
Sbjct: 127 PQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEK-GNVLLEDGKGRC 185
Query: 170 PYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISA 229
P+DP + +L++DGELY+GT + F G D AI R+ P +TE WL DP F+++
Sbjct: 186 PFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQS-LRPTKTES-SLNWLQDPAFVAS 243
Query: 230 HLISESDNP---EDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTF 286
I ES +DDK+YFFF E + E +RI +ICK D GG R L +WT+F
Sbjct: 244 AYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSF 303
Query: 287 LKARLICSVPGPNGIDTHFDELQDVFLM--NFKDPKNPVVYGVFTTS--SNIFKGSAVCM 342
LKA+L+CS P F+ LQDVF + + +D ++ + YGVFT+ +GSAVC+
Sbjct: 304 LKAQLLCSRPDDG---FPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV 360
Query: 343 YSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTC--PSKTFGGFDSTKDLPDDVI 400
++M DV+RVF G Y + QW VP PRPG C S +S+ LPD V+
Sbjct: 361 FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL 420
Query: 401 TFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLK 460
F + H M V +R ++++ YQ ++ V RV YDV+F+GT G + K
Sbjct: 421 NFLKDHFLMDGQV---RSRMLLLQPQARYQ--RVAVHRVPGLHHTYDVLFLGTGDGRLHK 475
Query: 461 VVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIY 520
VS+ ++EE+ +F + + L T + LY S +GV Q+P+ C +Y
Sbjct: 476 AVSVGPRVH------IIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY 529
Query: 521 GKACAECCLARDPYCAWDGSAC---SRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHH- 576
++C +C LARDPYCAW GS+C S Y P R QDI CS +
Sbjct: 530 -RSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSF 588
Query: 577 ---GHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQG 633
G P E++ + N+ L C S A W H++ T
Sbjct: 589 VPTGEKPCEQVQF-QPNTVNTLACPLLSNLATRLW----LRNGAPVNASASCHVLPTGDL 643
Query: 634 LLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVID 669
LL+ + Q G + C ++E GF Q + EV++
Sbjct: 644 LLVGTQQ---LGEFQCWSLEEGFQQLVASYCPEVVE 676
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 313 bits (802), Expect = 4e-85
Identities = 189/518 (36%), Positives = 269/518 (51%), Gaps = 48/518 (9%)
Query: 69 LYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKA 123
LY+ A+DHI++ D+ I +K+ W D C+ GK EC NFIKVL
Sbjct: 68 LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKH-KDECHNFIKVLLK 126
Query: 124 YNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLID 183
N L+ CGT AF+P C ++ D + + +G + PYD K +L D
Sbjct: 127 KNDDALFVCGTNAFNPSCR-----NYKMDTLEPFGDEF--SGMARCPYDAKHANVALFAD 179
Query: 184 GELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKV 243
G+LYS T DF+ D I+R+LG +RT +HDS+WL +P F+ A D +
Sbjct: 180 GKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQA-------VDYGDYI 232
Query: 244 YFFFRENAIDGEHSGKATHARIGQICKNDFGG-HRSLVNKWTTFLKARLICSVPGPNGID 302
YFFFRE A++ GK R+ Q+CKND GG R L +WT+FLKARL CSVPG D
Sbjct: 233 YFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPG----D 288
Query: 303 THF-----DELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYA 357
+HF + DV +N +D VV F+T N GSAVC Y M D+ VF G +
Sbjct: 289 SHFYFNILQAVTDVIRINGRD----VVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFK 344
Query: 358 HRDGPNYQWVPY-QGRVPYPRPGTCP-SKTFGGFDSTKDLPDDVITFARSHPAMYNPVFP 415
+ P+ W P RVP PRPG C S + + ++ + PDD + F ++HP M V
Sbjct: 345 EQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPS 404
Query: 416 MNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEV 475
+ NRP ++T V Y+ T+I VD + V+F+G++ G +LK ++ + + + +
Sbjct: 405 IFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSL 464
Query: 476 LLEEMTVFR---------EPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAE 526
LEEM+V+ E I M+L LY+ + V ++PL RC+ +GK
Sbjct: 465 FLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKT 524
Query: 527 CCLARDPYCAW--DGSACSRYFPTAKRRTRRQDIRNGD 562
C +RDPYC W +G ACS P + R T QDI G+
Sbjct: 525 CIASRDPYCGWIKEGGACSHLSPNS-RLTFEQDIERGN 561
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 305 bits (781), Expect = 1e-82
Identities = 189/546 (34%), Positives = 284/546 (52%), Gaps = 50/546 (9%)
Query: 66 RSRLYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
R LY+ +D +++ +L + +K+ W R+ C GK EC NFIKV
Sbjct: 66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTAS 179
N ++ CGT AF+P+C Y + LE E +G + P+D + +
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS--------TLEYDGEEISGLARCPFDARQTNVA 176
Query: 180 LLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPE 239
L DG+LYS T ADF+ D I+R++G +RT ++DS+W+ +P F+ H I
Sbjct: 177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFL--HAIEYG---- 230
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNK-WTTFLKARLICSVPGP 298
+ VYFFFRE A++ + GKA ++R+ +ICKND GG + ++ K WT+FLKARL CSVPG
Sbjct: 231 -NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 299 NGIDTHFDELQ---DVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGP 355
+ +FD LQ D+ +N P V GVFTT N GSAVC +SM D+ +VF G
Sbjct: 290 SFF--YFDVLQSITDIIQIN----GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGR 343
Query: 356 YAHRDGPNYQW--VPYQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNP 412
+ + P+ W VP + +VP PRPG C + ++ D PD+ ++F +SHP M +
Sbjct: 344 FKEQKTPDSVWTAVP-EDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSA 402
Query: 413 VFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDL 472
V P+ + P KT V Y+ T I VD Y V+F+G++ G VLKV++ K + + L
Sbjct: 403 VPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSL 460
Query: 473 -EEVLLEEMTVF---------REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGK 522
+ VLLEE+ + E + +++L LY+ ++ + ++PL RC+ YG
Sbjct: 461 NDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGS 520
Query: 523 ACAECCLARDPYCAW-DGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPE 581
C +RDPYC W +C R P QD G+ H D H +P+
Sbjct: 521 CKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGN-TAHLGDCHEILPTSTTPD 579
Query: 582 ERIIYG 587
+I G
Sbjct: 580 YKIFGG 585
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 305 bits (781), Expect = 1e-82
Identities = 189/546 (34%), Positives = 284/546 (52%), Gaps = 50/546 (9%)
Query: 66 RSRLYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
R LY+ +D +++ +L + +K+ W R+ C GK EC NFIKV
Sbjct: 66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTAS 179
N ++ CGT AF+P+C Y + LE E +G + P+D + +
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS--------TLEYDGEEISGLARCPFDARQTNVA 176
Query: 180 LLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPE 239
L DG+LYS T ADF+ D I+R++G +RT ++DS+W+ +P F+ H I
Sbjct: 177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFL--HAIEYG---- 230
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNK-WTTFLKARLICSVPGP 298
+ VYFFFRE A++ + GKA ++R+ +ICKND GG + ++ K WT+FLKARL CSVPG
Sbjct: 231 -NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 299 NGIDTHFDELQ---DVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGP 355
+ +FD LQ D+ +N P V GVFTT N GSAVC +SM D+ +VF G
Sbjct: 290 SFF--YFDVLQSITDIIQIN----GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGR 343
Query: 356 YAHRDGPNYQW--VPYQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNP 412
+ + P+ W VP + +VP PRPG C + ++ D PD+ ++F +SHP M +
Sbjct: 344 FKEQKTPDSVWTAVP-EDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSA 402
Query: 413 VFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDL 472
V P+ + P KT V Y+ T I VD Y V+F+G++ G VLKV++ K + + L
Sbjct: 403 VPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSL 460
Query: 473 -EEVLLEEMTVF---------REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGK 522
+ VLLEE+ + E + +++L LY+ ++ + ++PL RC+ YG
Sbjct: 461 NDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGS 520
Query: 523 ACAECCLARDPYCAW-DGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPE 581
C +RDPYC W +C R P QD G+ H D H +P+
Sbjct: 521 CKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGN-TAHLGDCHEILPTSTTPD 579
Query: 582 ERIIYG 587
+I G
Sbjct: 580 YKIFGG 585
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 303 bits (776), Expect = 4e-82
Identities = 186/530 (35%), Positives = 278/530 (52%), Gaps = 50/530 (9%)
Query: 66 RSRLYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
R LY+ +D +++ +L + +K+ W R+ C GK EC NFIKV
Sbjct: 66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTAS 179
N ++ CGT AF+P+C Y + LE E +G + P+D + +
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS--------TLEYDGEEISGLARCPFDARQTNVA 176
Query: 180 LLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPE 239
L DG+LYS T ADF+ D I+R++G +RT ++DS+W+ +P F+ H I
Sbjct: 177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFL--HAIEYG---- 230
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNK-WTTFLKARLICSVPGP 298
+ VYFFFRE A++ + GKA ++R+ +ICKND GG + ++ K WT+FLKARL CSVPG
Sbjct: 231 -NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 299 NGIDTHFDELQ---DVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGP 355
+ +FD LQ D+ +N P V GVFTT N GSAVC +SM D+ +VF G
Sbjct: 290 SFF--YFDVLQSITDIIQIN----GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGR 343
Query: 356 YAHRDGPNYQW--VPYQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNP 412
+ + P+ W VP + +VP PRPG C + ++ D PD+ ++F +SHP M +
Sbjct: 344 FKEQKTPDSVWTAVP-EDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSA 402
Query: 413 VFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDL 472
V P+ + P KT V Y+ T I VD Y V+F+G++ G VLKV++ K + + L
Sbjct: 403 VPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSL 460
Query: 473 -EEVLLEEMTVF---------REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGK 522
+ VLLEE+ + E + +++L LY+ ++ + ++PL RC+ YG
Sbjct: 461 NDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGS 520
Query: 523 ACAECCLARDPYCAW-DGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLH 571
C +RDPYC W +C R P QD G+ H D H
Sbjct: 521 CKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGN-TAHLGDCH 569
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 303 bits (776), Expect = 4e-82
Identities = 186/530 (35%), Positives = 278/530 (52%), Gaps = 50/530 (9%)
Query: 66 RSRLYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
R LY+ +D +++ +L + +K+ W R+ C GK EC NFIKV
Sbjct: 66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTAS 179
N ++ CGT AF+P+C Y + LE E +G + P+D + +
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS--------TLEYDGEEISGLARCPFDARQTNVA 176
Query: 180 LLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPE 239
L DG+LYS T ADF+ D I+R++G +RT ++DS+W+ +P F+ H I
Sbjct: 177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFL--HAIEYG---- 230
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNK-WTTFLKARLICSVPGP 298
+ VYFFFRE A++ + GKA ++R+ +ICKND GG + ++ K WT+FLKARL CSVPG
Sbjct: 231 -NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 299 NGIDTHFDELQ---DVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGP 355
+ +FD LQ D+ +N P V GVFTT N GSAVC +SM D+ +VF G
Sbjct: 290 SFF--YFDVLQSITDIIQIN----GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGR 343
Query: 356 YAHRDGPNYQW--VPYQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNP 412
+ + P+ W VP + +VP PRPG C + ++ D PD+ ++F +SHP M +
Sbjct: 344 FKEQKTPDSVWTAVP-EDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSA 402
Query: 413 VFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDL 472
V P+ + P KT V Y+ T I VD Y V+F+G++ G VLKV++ K + + L
Sbjct: 403 VPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSL 460
Query: 473 -EEVLLEEMTVF---------REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGK 522
+ VLLEE+ + E + +++L LY+ ++ + ++PL RC+ YG
Sbjct: 461 NDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGS 520
Query: 523 ACAECCLARDPYCAW-DGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLH 571
C +RDPYC W +C R P QD G+ H D H
Sbjct: 521 CKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGN-TAHLGDCH 569
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 301 bits (771), Expect = 2e-81
Identities = 199/629 (31%), Positives = 310/629 (49%), Gaps = 58/629 (9%)
Query: 41 ESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVN-----IKDFQKIVWPV 95
+ ++F + T LL + + LYVGA++ I + D+ + +K+ I WP
Sbjct: 48 DERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNM--IPWPA 105
Query: 96 SYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIF 155
S ++ EC + K +C NFI+VL +YN THLY CGT AF P CT+IE+ + +
Sbjct: 106 SDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIEL---QDSYLL 162
Query: 156 KLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQ 215
+ G+G+SP+DP ++L+DG LYSGT +F+G + + RTLG ++T+
Sbjct: 163 PISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDN 222
Query: 216 HDSRWL-NDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFG 274
RWL +D F++A P VYFFF E A + + + +R+ ++CKND G
Sbjct: 223 F-LRWLHHDASFVAA-------IPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVG 274
Query: 275 GHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNI 334
G + L KWTTFLKA+L+C+ PG F+ ++ L+ P P +Y VFT+ +
Sbjct: 275 GEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQV 330
Query: 335 --FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDST 392
+ SAVC +S+ D+ RVF G Y + +W Y+G PRPG+C S
Sbjct: 331 GGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC---------SV 381
Query: 393 KDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDG-QYDVMFI 451
D +TF + H M V P+++K+ V Y T++ V+ DG + VM++
Sbjct: 382 GPSSDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYL 436
Query: 452 GTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQ 511
GT G++ K V D L+EE+ +F +P + ++L+ Q +++G + GV +
Sbjct: 437 GTTTGSLHKAV-----VSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWR 491
Query: 512 LPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKR-RTRRQDIRNGDPLTHCSDL 570
+P C +Y ++C +C LARDP+CAWD + + +A + +QD+ G+P C+
Sbjct: 492 VPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASG 550
Query: 571 HHDNHHGHSPEERII---YGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHI 627
+II V NS L C S A YW V +
Sbjct: 551 PMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWS--------HGPAAVPEAS 602
Query: 628 IRTDQGLLLRSLQQKDSGNYLCHAVEHGF 656
G LL +Q G Y C A E+GF
Sbjct: 603 STVYNGSLLLIVQDGVGGLYQCWATENGF 631
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 299 bits (765), Expect = 7e-81
Identities = 180/506 (35%), Positives = 271/506 (53%), Gaps = 49/506 (9%)
Query: 66 RSRLYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
R LY+ +D +++ +L + +K+ W R+ C GK EC NFIKV
Sbjct: 66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTAS 179
N ++ CGT AF+P+C Y + LE E +G + P+D + +
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS--------TLEYDGEEISGLARCPFDARQTNVA 176
Query: 180 LLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPE 239
L DG+LYS T ADF+ D I+R++G +RT ++DS+W+ +P F+ H I
Sbjct: 177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFL--HAIEYG---- 230
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNK-WTTFLKARLICSVPGP 298
+ VYFFFRE A++ + GKA ++R+ +ICKND GG + ++ K WT+FLKARL CSVPG
Sbjct: 231 -NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 299 NGIDTHFDELQ---DVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGP 355
+ +FD LQ D+ +N P V GVFTT N GSAVC +SM D+ +VF G
Sbjct: 290 SFF--YFDVLQSITDIIQIN----GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGR 343
Query: 356 YAHRDGPNYQW--VPYQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNP 412
+ + P+ W VP + +VP PRPG C + ++ D PD+ ++F +SHP M +
Sbjct: 344 FKEQKTPDSVWTAVP-EDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSA 402
Query: 413 VFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDL 472
V P+ + P KT V Y+ T I VD Y V+F+G++ G VLKV++ K + + L
Sbjct: 403 VPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSL 460
Query: 473 -EEVLLEEMTVF---------REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGK 522
+ VLLEE+ + E + +++L LY+ ++ + ++PL RC+ YG
Sbjct: 461 NDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGS 520
Query: 523 ACAECCLARDPYCAW-DGSACSRYFP 547
C +RDPYC W +C R P
Sbjct: 521 CKKSCIASRDPYCGWLSQGSCGRVTP 546
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 286 bits (733), Expect = 4e-77
Identities = 174/483 (36%), Positives = 269/483 (55%), Gaps = 41/483 (8%)
Query: 62 LDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVL 121
LD ++L VGA++++F L N+ Q W S R C+ GK +EC N+++VL
Sbjct: 131 LDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTE-EECQNYVRVL 189
Query: 122 KAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKL-LTASL 180
+ ++ CGT AF P+CT ++G+ I K+ NG + PYDP+ TA +
Sbjct: 190 IVAGRK-VFMCGTNAFSPMCTSRQVGNLSR-TIEKI------NGVARCPYDPRHNSTAVI 241
Query: 181 LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED 240
GELY+ T DF GRD AI+R+LG P+RT Q++S+WLN+P F++A+ I
Sbjct: 242 SSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLF----- 296
Query: 241 DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG 300
YFF RENA++ + G+ ++R+ ++CKND GG L + WTTF+KARL CS PG
Sbjct: 297 --AYFFLRENAVEHD-CGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGE-- 351
Query: 301 IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD 360
+ +++ELQ F + P+ ++YGVFTT+ N SAVC +++S + + F GP+ +++
Sbjct: 352 VPFYYNELQSAFHL----PEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQE 407
Query: 361 GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP 420
P W+P +P + GT P ++L + + A+ M V P+ P
Sbjct: 408 NPRAAWLPIANPIPNFQCGTLPET-----GPNENLTERSLQDAQRLFLMSEAVQPVTPEP 462
Query: 421 IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM 480
V + V +F+ +VVD V A+D Y V++IGT+ GT+LK +S + L LEE+
Sbjct: 463 CVTQDSV--RFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRS---LHGCYLEEL 517
Query: 481 TVF----REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCA 536
V REP + ++ + + L++G GV ++PL RC Y ++ C ARDPYC
Sbjct: 518 HVLPPGRREP--LRSLRILHSARALFVGLRDGVLRVPLERCAAY-RSQGACLGARDPYCG 574
Query: 537 WDG 539
WDG
Sbjct: 575 WDG 577
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 279 bits (713), Expect = 8e-75
Identities = 185/540 (34%), Positives = 281/540 (52%), Gaps = 59/540 (10%)
Query: 32 LKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER-----SRLYVGAKDHIFSFDLVNIK 86
L L ++ ++ + F GL + + LD +R L V A+DH+FSFDL +
Sbjct: 31 LPLLISDLQGTSPLSWFRGLEDDAVAAELGLDFQRFLTLNRTLLVAARDHVFSFDLQAEE 90
Query: 87 DFQKIVWPVSYTRRDE----CKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICT 142
+ + +V T R + C GK + EC N+I+VL ++ L ACGT +F P+C
Sbjct: 91 EGEGLVPNKYLTWRSQDVENCAVRGK-LTDECYNYIRVLVPWDSQTLLACGTNSFSPVCR 149
Query: 143 YIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAI 201
I L+ E +G+ + P+D ++ +G LYS TAADF D +
Sbjct: 150 SY--------GITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVV 201
Query: 202 FRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKAT 261
+R+LG P+R+ ++DS+WL +P F+ A D VYFFFRE +++ G+
Sbjct: 202 YRSLGPQPPLRSAKYDSKWLREPHFVQA-------LEHGDHVYFFFREVSVEDARLGRVQ 254
Query: 262 HARIGQICKNDFGGH-RSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPK 320
+R+ ++CK D GG R+L WT+FLK RL CSVPG + +FD LQ + P
Sbjct: 255 FSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQAL-----TGPV 307
Query: 321 N----PVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPY-QGRVPY 375
N ++GVFTT +N GSAVC + + ++ R F G + + + W P + RVP
Sbjct: 308 NLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPS 367
Query: 376 PRPGTCPSKTFGG---FDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFT 432
PRPG+C GG F S++DLPDDV+TF ++HP + V P+ ++P++ T T
Sbjct: 368 PRPGSCAG--VGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTS-RALLT 424
Query: 433 QIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVF--------- 483
Q+ VD + VMF+G++ GTVLKV++ P E +LLEE+ +
Sbjct: 425 QVAVDGMAGPHSNITVMFLGSNDGTVLKVLT-PGGRSGGPEPILLEEIDAYSPARCSGKR 483
Query: 484 --REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLA-RDPYCAWDGS 540
+ I +EL T+ +L++ + + LPL RC +G AC CLA +DPYC W S
Sbjct: 484 TAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHG-ACQRSCLASQDPYCGWHSS 542
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 270 bits (690), Expect = 4e-72
Identities = 189/591 (31%), Positives = 290/591 (49%), Gaps = 41/591 (6%)
Query: 28 NVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDL-VNIK 86
+VPR L E +++ +T + ++ +Y L+D LYVGA+D IF+ L + +
Sbjct: 39 SVPRTSLPISE---ADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGE 95
Query: 87 DFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEI 146
++I W V R C+ GK EC NF+++L N +HL CGT AF P C I++
Sbjct: 96 RPRRIDWMVPEAHRQNCRKKGKKE-DECHNFVQILAIANASHLLTCGTFAFDPKCGVIDV 154
Query: 147 GHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLG 206
+ E+GRGK P++P +A+++ G LY+ T +++G + I R +G
Sbjct: 155 SRFQQVE-------RLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVG 207
Query: 207 HHHP-IRTEQHDSRWLNDPKFISAHLISES---DNPEDDKVYFFFRENAIDGEHSGKATH 262
IRT+ S WLN P F++A +S + D DD++YFFF E + + +
Sbjct: 208 RAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKV 266
Query: 263 ARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFK-DPKN 321
R+ ++C D GG ++L +WTTFLKA L+C PGP LQDV ++ +
Sbjct: 267 PRVARVCAGDLGGRKTLQQRWTTFLKADLLC--PGPEH-GRASSVLQDVAVLRPELGAGT 323
Query: 322 PVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVP-YQGRVPYPRPGT 380
P+ YG+F++ SAVC + D+R V GP+ + +P VP PRPG
Sbjct: 324 PIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGE 383
Query: 381 CPSKT--FGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDR 438
C + F S+ LPD V+TF R HP M PVFP + P+++ TD Y ++V R
Sbjct: 384 CITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAY--LRVVAHR 441
Query: 439 VDAEDG-QYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTK 497
V + G +YDV+++GT+ G + + V I + +LE++ +F EP + M+L
Sbjct: 442 VTSLSGKEYDVLYLGTEDGHLHRAVRIGAQL------SVLEDLALFPEPQPVENMKL--Y 493
Query: 498 QQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQD 557
L +GS V Q+ C ++C+EC LA+DP CAW + R QD
Sbjct: 494 HSWLLVGSRTEVTQVNTTNCGRL-QSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQD 552
Query: 558 IRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYW 608
I + D + C G P + + L CSP S A W
Sbjct: 553 IESADVSSLC-----PKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVW 598
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 266 bits (680), Expect = 5e-71
Identities = 166/493 (33%), Positives = 262/493 (53%), Gaps = 46/493 (9%)
Query: 53 NSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILK 112
N+ + D + L VGA++++F L ++ Q + W + C GK +
Sbjct: 54 NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKS-KE 112
Query: 113 ECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPE--DNIFKLENSHFENGRGKSP 170
EC N+I+VL L+ CGT AF P+CT + + E D I +G + P
Sbjct: 113 ECQNYIRVLLVGGD-RLFTCGTNAFTPVCTNRSLSNLTEIHDQI---------SGMARCP 162
Query: 171 YDPKL-LTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISA 229
Y P+ TA L GELY+ TA DF GRD AI+R+LG P+RT Q++S+WLN+P F+S+
Sbjct: 163 YSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSS 222
Query: 230 HLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKA 289
+ I + YFFFRENA++ + GK +R ++CKND GG L + WTTF+KA
Sbjct: 223 YDIG-------NFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKA 274
Query: 290 RLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVR 349
RL CS PG + +++ELQ F + P+ ++YG+FTT+ N SAVC++++S +
Sbjct: 275 RLNCSRPGE--VPFYYNELQSTFFL----PELDLIYGIFTTNVNSIAASAVCVFNLSAIA 328
Query: 350 RVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAM 409
+ F GP+ +++ W+PY P+ + GT + + ++L D A+ M
Sbjct: 329 QAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNL-TERNLQD-----AQKFILM 382
Query: 410 YNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETW 469
+ V P+ P ++ N +F+ + VD V + ++++ TD GT+ KV +T
Sbjct: 383 HEVVQPVTTVPSFMED--NSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQT- 439
Query: 470 YDLEEVLLEEMTVF----REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACA 525
LLEE+ +F REP I ++++ Q L++G V ++PL RC Y + +
Sbjct: 440 --SSSCLLEEIELFPERRREP--IRSLQILHSQSVLFVGLREHVVKIPLKRCQFY-RTRS 494
Query: 526 ECCLARDPYCAWD 538
C A+DPYC WD
Sbjct: 495 TCIGAQDPYCGWD 507
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 263 bits (671), Expect = 6e-70
Identities = 163/512 (31%), Positives = 258/512 (50%), Gaps = 43/512 (8%)
Query: 69 LYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKA 123
L++G +D+++ +L ++ +K+ W + + + C+ GK EC NF+KVL
Sbjct: 77 LFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQE-GECRNFVKVLLL 135
Query: 124 YNQTHLYACGTGAFHPICTYIEIG--HHPEDNIFKLENSHFENGRGKSPYDPKLLTASLL 181
+++ L+ CG+ AF+P+C I DNI +G + PYDPK +L
Sbjct: 136 RDESTLFVCGSNAFNPVCANYSIDTLQPVGDNI---------SGMARCPYDPKHANVALF 186
Query: 182 IDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDD 241
DG L++ T DF+ D I+R+LG +RT +HDS+W +P F+ H + +
Sbjct: 187 SDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFV--HAVEWGSH---- 240
Query: 242 KVYFFFRENAIDGEHSGKATHARIGQICKNDFGGH-RSLVNKWTTFLKARLICSVPGPNG 300
VYFFFRE A++ + K +R+ ++CKND GG R L +WT+FLKARL CSVPG +
Sbjct: 241 -VYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSH 299
Query: 301 IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD 360
+F+ LQ V + + PVV VF+T SN GSAVC + ++ V VF G + +
Sbjct: 300 F--YFNVLQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQK 356
Query: 361 GPNYQWVPY-QGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNR 419
P W P + +VP PRPG C + ++++ LPDD++ F ++HP M V + +
Sbjct: 357 SPESIWTPVPEDQVPRPRPGCCAAPGM-QYNASSALPDDILNFVKTHPLMDEAVPSLGHA 415
Query: 420 PIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLE--EVLL 477
P +++T + +Q T++ VD G V+F+G++ GTVLK + P + V L
Sbjct: 416 PWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFL 475
Query: 478 EEMTVFREPTA-----------ISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAE 526
EE +R + ++EL L V ++P+ RC Y
Sbjct: 476 EEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKN 535
Query: 527 CCLARDPYCAWDGSACSRYFPTAKRRTRRQDI 558
C ++DPYC W + R QD+
Sbjct: 536 CIGSQDPYCGWAPDGSCIFLSPGTRAAFEQDV 567
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 262 bits (670), Expect = 8e-70
Identities = 160/432 (37%), Positives = 238/432 (55%), Gaps = 39/432 (9%)
Query: 66 RSRLYVGAKDHIFSFDL-----VNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV 120
R LY+ +D +++ +L + +K+ W R+ C GK EC NFIKV
Sbjct: 66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKV 124
Query: 121 LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFE-NGRGKSPYDPKLLTAS 179
N ++ CGT AF+P+C Y + LE E +G + P+D + +
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLS--------TLEYDGEEISGLARCPFDARQTNVA 176
Query: 180 LLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPE 239
L DG+LYS T ADF+ D I+R++G +RT ++DS+W+ +P F+ H I
Sbjct: 177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFL--HAIEYG---- 230
Query: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNK-WTTFLKARLICSVPGP 298
+ VYFFFRE A++ + GKA ++R+ +ICKND GG + ++ K WT+FLKARL CSVPG
Sbjct: 231 -NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 299 NGIDTHFDELQ---DVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGP 355
+ +FD LQ D+ +N P V GVFTT N GSAVC +SM D+ +VF G
Sbjct: 290 SFF--YFDVLQSITDIIQIN----GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGR 343
Query: 356 YAHRDGPNYQW--VPYQGRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNP 412
+ + P+ W VP + +VP PRPG C + ++ D PD+ ++F +SHP M +
Sbjct: 344 FKEQKTPDSVWTAVP-EDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSA 402
Query: 413 VFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDL 472
V P+ + P KT V Y+ T I VD Y V+F+G++ G VLKV++ K + + L
Sbjct: 403 VPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLA--KTSPFSL 460
Query: 473 -EEVLLEEMTVF 483
+ VLLEE+ +
Sbjct: 461 NDSVLLEEIEAY 472
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 228 bits (581), Expect = 2e-59
Identities = 189/664 (28%), Positives = 303/664 (45%), Gaps = 84/664 (12%)
Query: 6 RIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEE 65
R++ L W +A+ + ++G PR+ +K + + V + HT L E
Sbjct: 32 RLLLLLWAAAASAQGHLRSG----PRIFAVWKGHVGQDRVDF-----GQTEPHTVLFHEP 82
Query: 66 -RSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILK-ECANFIKVLKA 123
S ++VG + ++ FD K+ + T+ G + K +C N+I +L+
Sbjct: 83 GSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTK-------GSCLDKRDCENYITLLER 135
Query: 124 YNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLID 183
++ L ACGT A HP C + G + L RG +P+ P + L
Sbjct: 136 RSEG-LLACGTNARHPSCWNLVNG-----TVVPLGEM-----RGYAPFSPDENSLVLFEG 184
Query: 184 GELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKV 243
E+YS FR + + T + +P+FI A ++ + D DDK+
Sbjct: 185 DEVYSTIRKQEYNGKIPRFRRIRGESELYTSD---TVMQNPQFIKATIVHQ-DQAYDDKI 240
Query: 244 YFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSL-VNKWTTFLKARLICSVPGPNGID 302
Y+FFRE+ D +R+ Q+C+ D GG SL V+KW TFLKA L+CS N
Sbjct: 241 YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN--- 297
Query: 303 THFDELQDVFLMNFKDP----KNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAH 358
+F+ LQDVFL+ DP ++ VYGVF SN + SAVC+YS+ D+ +VF
Sbjct: 298 KNFNRLQDVFLL--PDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFR----- 347
Query: 359 RDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNN 418
Y +P PRPG C + +P + A HP + V PM
Sbjct: 348 ----TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
Query: 419 RPIVIKTDV---NYQFTQIVVDRVDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEE 474
+KT + Y + ++ V R+ A G+ + V+++ TD GT+ KVV P E +
Sbjct: 397 ----LKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE-PGEQEHSFAF 451
Query: 475 VLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPY 534
++E + FR AI M L ++++LY+ S V+Q+PL C++YG C C ++RDPY
Sbjct: 452 NIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPY 510
Query: 535 CAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTF 594
C WD C + + R+ Q I +P C + D +P +++ NS +
Sbjct: 511 CGWDQGRCISIY--SSERSVLQSINPAEPHKECPNPKPDK----APLQKVSL-APNSRYY 563
Query: 595 LECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEH 654
L C +S+ A W+ + E+ E + I L + +L + G+Y C A E
Sbjct: 564 LSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEG 618
Query: 655 GFIQ 658
+ +
Sbjct: 619 SYFR 622
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 226 bits (577), Expect = 5e-59
Identities = 186/663 (28%), Positives = 298/663 (44%), Gaps = 96/663 (14%)
Query: 6 RIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEE 65
R++ L W +A+ + ++G PR+ +K + + V + HT L E
Sbjct: 32 RLLLLLWAAAASAQGHLRSG----PRIFAVWKGHVGQDRVDF-----GQTEPHTVLFHEP 82
Query: 66 -RSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAY 124
S ++VG + ++ FD K+ + +C N+I +L+
Sbjct: 83 GSSSVWVGGRGKVYLFDFPEGKN--------------------ASVRTDCENYITLLERR 122
Query: 125 NQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDG 184
++ L ACGT A HP C + G + L RG +P+ P + L
Sbjct: 123 SEG-LLACGTNARHPSCWNLVNG-----TVVPLGEM-----RGYAPFSPDENSLVLFEGD 171
Query: 185 ELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKVY 244
E+YS FR + + T + +P+FI A ++ + D DDK+Y
Sbjct: 172 EVYSTIRKQEYNGKIPRFRRIRGESELYTSD---TVMQNPQFIKATIVHQ-DQAYDDKIY 227
Query: 245 FFFRENAIDGEHSGKATHARIGQICKNDFGGHRSL-VNKWTTFLKARLICSVPGPNGIDT 303
+FFRE+ D +R+ Q+C+ D GG SL V+KW TFLKA L+CS N
Sbjct: 228 YFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN---K 284
Query: 304 HFDELQDVFLMNFKDP----KNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHR 359
+F+ LQDVFL+ DP ++ VYGVF SN + SAVC+YS+ D+ +VF
Sbjct: 285 NFNRLQDVFLL--PDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFR------ 333
Query: 360 DGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNR 419
Y +P PRPG C + +P + A HP + V PM
Sbjct: 334 ---TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHPEVAQRVEPMGP- 382
Query: 420 PIVIKTDV---NYQFTQIVVDRVDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEEV 475
+KT + Y + ++ V R+ A G+ + V+++ TD GT+ KVV P E +
Sbjct: 383 ---LKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE-PGEQEHSFAFN 438
Query: 476 LLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYC 535
++E + FR AI M L ++++LY+ S V+Q+PL C++YG C C ++RDPYC
Sbjct: 439 IME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYC 497
Query: 536 AWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFL 595
WD C + + R+ Q I +P C + D +P +++ NS +L
Sbjct: 498 GWDQGRCISIY--SSERSVLQSINPAEPHKECPNPKPDK----APLQKVSL-APNSRYYL 550
Query: 596 ECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHG 655
C +S+ A W+ + E+ E + I L + +L + G+Y C A E
Sbjct: 551 SCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEGS 605
Query: 656 FIQ 658
+ +
Sbjct: 606 YFR 608
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 207 bits (527), Expect = 3e-53
Identities = 152/502 (30%), Positives = 237/502 (47%), Gaps = 55/502 (10%)
Query: 166 RGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPK 225
RG +P+ P + L E+YS FR + + T + +P+
Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSD---TVMQNPQ 58
Query: 226 FISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSL-VNKWT 284
FI A ++ + D DDK+Y+FFRE+ D +R+ Q+C+ D GG SL V+KW
Sbjct: 59 FIKATIVHQ-DQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWN 117
Query: 285 TFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDP----KNPVVYGVFTTSSNIFKGSAV 340
TFLKA L+CS N +F+ LQDVFL+ DP ++ VYGVF SN + SAV
Sbjct: 118 TFLKAMLVCSDAATN---KNFNRLQDVFLL--PDPSGQWRDTRVYGVF---SNPWNYSAV 169
Query: 341 CMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVI 400
C+YS+ D+ +VF Y +P PRPG C + +P +
Sbjct: 170 CVYSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETF 213
Query: 401 TFARSHPAMYNPVFPMNNRPIVIKTDV---NYQFTQIVVDRVDAEDGQ-YDVMFIGTDVG 456
A HP + V PM +KT + Y + ++ V R+ A G+ + V+++ TD G
Sbjct: 214 QVADRHPEVAQRVEPMGP----LKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRG 269
Query: 457 TVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHR 516
T+ KVV P E + ++E + FR AI M L ++++LY+ S V+Q+PL
Sbjct: 270 TIHKVVE-PGEQEHSFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDL 327
Query: 517 CDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHH 576
C++YG C C ++RDPYC WD C + + R+ Q I +P C + D
Sbjct: 328 CEVYGGGCHGCLMSRDPYCGWDQGRCISIY--SSERSVLQSINPAEPHKECPNPKPDK-- 383
Query: 577 GHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLL 636
+P +++ NS +L C +S+ A W+ + E+ E + I L +
Sbjct: 384 --APLQKVSL-APNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFI 435
Query: 637 RSLQQKDSGNYLCHAVEHGFIQ 658
+L + G+Y C A E + +
Sbjct: 436 ENLTAQQYGHYFCEAQEGSYFR 457
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,240,365
Number of Sequences: 37866
Number of extensions: 1554644
Number of successful extensions: 4327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 3997
Number of HSP's gapped (non-prelim): 131
length of query: 771
length of database: 18,247,518
effective HSP length: 110
effective length of query: 661
effective length of database: 14,082,258
effective search space: 9308372538
effective search space used: 9308372538
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.