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Search of human proteins with 51242955
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens] 872 0.0
gi|51242960 protein kinase LYK5 isoform 2 [Homo sapiens] 790 0.0
gi|51242957 protein kinase LYK5 isoform 4 [Homo sapiens] 759 0.0
gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens] 662 0.0
gi|13027388 STE20-related kinase adaptor beta [Homo sapiens] 325 5e-89
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 155 9e-38
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 154 1e-37
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 115 8e-26
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 113 4e-25
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 113 4e-25
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 112 6e-25
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 112 8e-25
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 110 2e-24
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 110 2e-24
gi|191252782 p21-activated kinase 6 [Homo sapiens] 108 1e-23
gi|191252780 p21-activated kinase 6 [Homo sapiens] 108 1e-23
gi|9910476 p21-activated kinase 6 [Homo sapiens] 108 1e-23
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 103 2e-22
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 103 2e-22
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 103 3e-22
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 103 3e-22
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 103 4e-22
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 102 7e-22
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 102 7e-22
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 102 7e-22
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 102 7e-22
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 102 7e-22
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 102 7e-22
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 101 1e-21
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 101 1e-21
>gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens]
Length = 431
Score = 872 bits (2252), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDTRRKTNDASSESIASFSKQEVMS 60
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDTRRKTNDASSESIASFSKQEVMS
Sbjct: 1 MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDTRRKTNDASSESIASFSKQEVMS 60
Query: 61 SFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELH 120
SFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELH
Sbjct: 61 SFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELH 120
Query: 121 VSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVL 180
VSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVL
Sbjct: 121 VSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVL 180
Query: 181 KALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV 240
KALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV
Sbjct: 181 KALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV 240
Query: 241 LPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLL 300
LPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLL
Sbjct: 241 LPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLL 300
Query: 301 DTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCL 360
DTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCL
Sbjct: 301 DTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCL 360
Query: 361 QRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTN 420
QRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTN
Sbjct: 361 QRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTN 420
Query: 421 LEELEVDDWEF 431
LEELEVDDWEF
Sbjct: 421 LEELEVDDWEF 431
>gi|51242960 protein kinase LYK5 isoform 2 [Homo sapiens]
Length = 394
Score = 790 bits (2039), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 42 TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR 101
TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR
Sbjct: 5 TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR 64
Query: 102 INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT 161
INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT
Sbjct: 65 INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT 124
Query: 162 HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI 221
HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI
Sbjct: 125 HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI 184
Query: 222 SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 281
SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD
Sbjct: 185 SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 244
Query: 282 MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS 341
MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS
Sbjct: 245 MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS 304
Query: 342 HPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPIT 401
HPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPIT
Sbjct: 305 HPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPIT 364
Query: 402 NFEGSQSQDHSGIFGLVTNLEELEVDDWEF 431
NFEGSQSQDHSGIFGLVTNLEELEVDDWEF
Sbjct: 365 NFEGSQSQDHSGIFGLVTNLEELEVDDWEF 394
>gi|51242957 protein kinase LYK5 isoform 4 [Homo sapiens]
Length = 373
Score = 759 bits (1960), Expect = 0.0
Identities = 373/373 (100%), Positives = 373/373 (100%)
Query: 59 MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGE 118
MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGE
Sbjct: 1 MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGE 60
Query: 119 LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG 178
LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG
Sbjct: 61 LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG 120
Query: 179 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV 238
VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV
Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV 180
Query: 239 KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 298
KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC
Sbjct: 181 KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 240
Query: 299 LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ 358
LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ
Sbjct: 241 LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ 300
Query: 359 CLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLV 418
CLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLV
Sbjct: 301 CLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLV 360
Query: 419 TNLEELEVDDWEF 431
TNLEELEVDDWEF
Sbjct: 361 TNLEELEVDDWEF 373
>gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens]
Length = 348
Score = 662 bits (1709), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 42 TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR 101
TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR
Sbjct: 5 TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR 64
Query: 102 INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT 161
INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT
Sbjct: 65 INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT 124
Query: 162 HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI 221
HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI
Sbjct: 125 HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI 184
Query: 222 SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 281
SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD
Sbjct: 185 SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 244
Query: 282 MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS 341
MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS
Sbjct: 245 MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS 304
Query: 342 HPYHRTFSPHFHHFVEQCLQRNPDAR 367
HPYHRTFSPHFHHFVEQCLQRNPDAR
Sbjct: 305 HPYHRTFSPHFHHFVEQCLQRNPDAR 330
>gi|13027388 STE20-related kinase adaptor beta [Homo sapiens]
Length = 418
Score = 325 bits (833), Expect = 5e-89
Identities = 168/329 (51%), Positives = 222/329 (67%), Gaps = 1/329 (0%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
YEL IG+GF++L +V+LAR+ PTG VT++ NLE C+ E + LQ + +S F HP
Sbjct: 58 YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
NI Y F + LWV++ FMAYGSA L+ T+F +GM+E I IL G ++ L+Y+H
Sbjct: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
Query: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248
G +HRS+KASHILIS DG V LSGL S++ HGQR R V+DFP++S V PWLSPE+
Sbjct: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
Query: 249 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 308
L+Q+L GY+ KSDIYSVGITACELA+G VPF+DM TQMLL+KL G LD S P
Sbjct: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQS 297
Query: 309 ELTMSPSRSVANSGLSDS-LTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 367
E M S+S +SG+ +S L +S N D P +TFSP F V+ CLQ++P+ R
Sbjct: 298 ESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKR 357
Query: 368 PSASTLLNHSFFKQIKRRASEALPELLRP 396
PSAS+LL+H FFKQ+K + +++ LL P
Sbjct: 358 PSASSLLSHVFFKQMKEESQDSILSLLPP 386
>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
[Homo sapiens]
Length = 545
Score = 155 bits (391), Expect = 9e-38
Identities = 116/369 (31%), Positives = 173/369 (46%), Gaps = 53/369 (14%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
YEL VIG G + V A KP E V ++RINLE C M L+ E+ +HP
Sbjct: 63 YELQEVIGSGATAV--VQAALCKPRQERVAIKRINLEKCQTSMDELLK-EIQAMSQCSHP 119
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLIC------THFMDGMNELAIAYILQGVLKA 182
N+V Y +F+ +ELW+V ++ GS D+I H + E IA IL+ VL+
Sbjct: 120 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 179
Query: 183 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP 242
LDY+H G +HR +KA +IL+ DG V ++ + + + G R + K V
Sbjct: 180 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTR--NKVRKTFVGTPC 237
Query: 243 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 302
W++PEV++Q ++GYD K+D++S GITA ELA G P+ P ++L+ L P L
Sbjct: 238 WMAPEVMEQ-VRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTL--- 293
Query: 303 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 362
+G+ D + + F + CLQ+
Sbjct: 294 -----------------ETGVEDK----------------EMMKKYGKSFRKLLSLCLQK 320
Query: 363 NPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTNLE 422
+P RP+A+ LL FF++ K R E L E L TP + + G G +L
Sbjct: 321 DPSKRPTAAELLKCKFFQKAKNR--EYLIEKLLTRTPDIAQRAKKVRRVPGSSG---HLH 375
Query: 423 ELEVDDWEF 431
+ E DWE+
Sbjct: 376 KTEDGDWEW 384
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 154 bits (390), Expect = 1e-37
Identities = 114/369 (30%), Positives = 172/369 (46%), Gaps = 53/369 (14%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
YEL VIG G + V A P E V ++RINLE C M L+ E+ +HP
Sbjct: 17 YELQEVIGSGATAV--VQAAYCAPKKEKVAIKRINLEKCQTSMDELLK-EIQAMSQCHHP 73
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLIC------THFMDGMNELAIAYILQGVLKA 182
NIV Y +F+ +ELW+V ++ GS D+I H ++E IA IL+ VL+
Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
Query: 183 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP 242
L+Y+H G +HR VKA +IL+ DG V ++ + + + G R + K V
Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITR--NKVRKTFVGTPC 191
Query: 243 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 302
W++PEV++Q ++GYD K+DI+S GITA ELA G P+ P ++L+ L P L
Sbjct: 192 WMAPEVMEQ-VRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSL--- 247
Query: 303 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 362
+G+ D + + F + CLQ+
Sbjct: 248 -----------------ETGVQDK----------------EMLKKYGKSFRKMISLCLQK 274
Query: 363 NPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTNLE 422
+P+ RP+A+ LL H FF++ K + E L E P + + + G G L
Sbjct: 275 DPEKRPTAAELLRHKFFQKAKNK--EFLQEKTLQRAPTISERAKKVRRVPGSSG---RLH 329
Query: 423 ELEVDDWEF 431
+ E WE+
Sbjct: 330 KTEDGGWEW 338
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 115 bits (288), Expect = 8e-26
Identities = 84/315 (26%), Positives = 149/315 (47%), Gaps = 59/315 (18%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
+++L +G+G +V A +K TG+ V ++++ +E+ E++ E+ + + + P
Sbjct: 30 FDVLEKLGEG--SYGSVYKAIHKETGQIVAIKQVPVESDLQEIIK----EISIMQQCDSP 83
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
++V Y ++ + +LW+V + GS D+I + E IA ILQ LK L+Y+H
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT-LTEDEIATILQSTLKGLEYLHF 142
Query: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248
M +HR +KA +IL++ +G L+ + ++ V P W++PEV
Sbjct: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF-------WMAPEV 195
Query: 249 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 308
+Q+ GY+ +DI+S+GITA E+A G P+ D+ P
Sbjct: 196 IQE--IGYNCVADIWSLGITAIEMAEGKPPYADIH----------------------PMR 231
Query: 309 ELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARP 368
+ M P T+ P P+ +S +F FV+QCL ++P+ R
Sbjct: 232 AIFMIP--------------TNPP-------PTFRKPELWSDNFTDFVKQCLVKSPEQRA 270
Query: 369 SASTLLNHSFFKQIK 383
+A+ LL H F + K
Sbjct: 271 TATQLLQHPFVRSAK 285
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 113 bits (282), Expect = 4e-25
Identities = 90/322 (27%), Positives = 147/322 (45%), Gaps = 66/322 (20%)
Query: 93 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 152
T + V ++ I+LE +E + +Q E+ V + P + Y +++ D +LW++ ++
Sbjct: 46 TQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG 104
Query: 153 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 212
GSA DL+ +D E IA IL+ +LK LDY+H +HR +KA+++L+S G+V L+
Sbjct: 105 GSALDLLEPGPLD---ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 213 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 270
G+ L+ + V F W++PEV++Q+ YD+K+DI+S+GITA
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIKQS--AYDSKADIWSLGITAI 210
Query: 271 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTS 330
ELA G P ++ ++L P L + P +E
Sbjct: 211 ELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKE--------------------- 249
Query: 331 TPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEAL 390
FVE CL + P RP+A LL H F + ++ S L
Sbjct: 250 ------------------------FVEACLNKEPSFRPTAKELLKHKFILRNAKKTS-YL 284
Query: 391 PELLRPVTPITNFEGSQSQDHS 412
EL + ++ QS D S
Sbjct: 285 TEL---IDRYKRWKAEQSHDDS 303
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 113 bits (282), Expect = 4e-25
Identities = 90/322 (27%), Positives = 147/322 (45%), Gaps = 66/322 (20%)
Query: 93 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 152
T + V ++ I+LE +E + +Q E+ V + P + Y +++ D +LW++ ++
Sbjct: 58 TQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG 116
Query: 153 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 212
GSA DL+ +D E IA IL+ +LK LDY+H +HR +KA+++L+S G+V L+
Sbjct: 117 GSALDLLEPGPLD---ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLA 173
Query: 213 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 270
G+ L+ + V F W++PEV++Q+ YD+K+DI+S+GITA
Sbjct: 174 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIKQS--AYDSKADIWSLGITAI 222
Query: 271 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTS 330
ELA G P ++ ++L P L + P +E
Sbjct: 223 ELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKE--------------------- 261
Query: 331 TPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEAL 390
FVE CL + P RP+A LL H F + ++ S L
Sbjct: 262 ------------------------FVEACLNKEPSFRPTAKELLKHKFILRNAKKTS-YL 296
Query: 391 PELLRPVTPITNFEGSQSQDHS 412
EL + ++ QS D S
Sbjct: 297 TEL---IDRYKRWKAEQSHDDS 315
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 112 bits (280), Expect = 6e-25
Identities = 90/322 (27%), Positives = 148/322 (45%), Gaps = 69/322 (21%)
Query: 93 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 152
T + V ++ I+LE +E + +Q E+ V + + Y +++ ++LW++ ++
Sbjct: 46 TQQVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGG 104
Query: 153 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 212
GSA DL+ D E IA +L+ +LK LDY+H +HR +KA+++L+S G V L+
Sbjct: 105 GSALDLLRAGPFD---EFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 213 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 270
G+ L+ + V F W++PEV+QQ+ YD+K+DI+S+GITA
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIQQS--AYDSKADIWSLGITAI 210
Query: 271 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTS 330
ELA G P DM ++L P L+
Sbjct: 211 ELAKGEPPNSDMHPMRVLFLIPKNNPPTLV------------------------------ 240
Query: 331 TPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEAL 390
GD F+ F F++ CL ++P RP+A LL H F + ++ S L
Sbjct: 241 ------GD---------FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTS-YL 284
Query: 391 PELLRPVTPITNFEGSQSQDHS 412
EL I F+ +++ HS
Sbjct: 285 TEL------IDRFKRWKAEGHS 300
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 112 bits (279), Expect = 8e-25
Identities = 95/331 (28%), Positives = 145/331 (43%), Gaps = 57/331 (17%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
+EL+ IG G V AR TGE ++ I LE E +Q E+ + K HP
Sbjct: 16 FELIQRIGSGTYG--DVYKARNVNTGELAAIKVIKLEP--GEDFAVVQQEIIMMKDCKHP 71
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
NIV Y +++ ++LW+ F GS +D+ H ++EL IAY+ + L+ L Y+H
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIY--HVTGPLSELQIAYVSRETLQGLYYLHS 129
Query: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248
G +HR +K ++IL++ +G V L+ + + + +++ P W++PEV
Sbjct: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY-------WMAPEV 182
Query: 249 LQ-QNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPA 307
+ GY+ D+++VGITA ELA P D+ + L
Sbjct: 183 AAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALF------------------ 224
Query: 308 EELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 367
L T SN P +S FHHFV+ L +NP R
Sbjct: 225 -------------------LMTK----SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKR 261
Query: 368 PSASTLLNHSFFKQIKRR--ASEALPELLRP 396
P+A LL H F Q R A E L ++ P
Sbjct: 262 PTAEKLLQHPFVTQHLTRSLAIELLDKVNNP 292
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 110 bits (276), Expect = 2e-24
Identities = 91/352 (25%), Positives = 160/352 (45%), Gaps = 71/352 (20%)
Query: 32 EQPPGDTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYK 91
EQPP + K S +S+ +EV +++L +G+G +V A +K
Sbjct: 2 EQPPAP-KSKLKKLSEDSLTK-QPEEV----------FDVLEKLGEG--SYGSVFKAIHK 47
Query: 92 PTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMA 151
+G+ V ++++ +E+ E++ E+ + + + P +V Y ++ + +LW+V +
Sbjct: 48 ESGQVVAIKQVPVESDLQEIIK----EISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCG 103
Query: 152 YGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYL 211
GS D+I + E IA IL+ LK L+Y+H M +HR +KA +IL++ +G L
Sbjct: 104 AGSVSDIIRLRNKT-LIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKL 162
Query: 212 SGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACE 271
+ + ++ V P W++PEV+Q+ GY+ +DI+S+GIT+ E
Sbjct: 163 ADFGVAGQLTDTMAKRNTVIGTPF-------WMAPEVIQE--IGYNCVADIWSLGITSIE 213
Query: 272 LANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTST 331
+A G P+ D+ P + M P T+
Sbjct: 214 MAEGKPPYADIH----------------------PMRAIFMIP--------------TNP 237
Query: 332 PRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIK 383
P P+ +S F FV++CL +NP+ R +A+ LL H F K K
Sbjct: 238 P-------PTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK 282
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 110 bits (275), Expect = 2e-24
Identities = 87/297 (29%), Positives = 134/297 (45%), Gaps = 62/297 (20%)
Query: 93 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 152
T E V ++ I+LE +E + +Q E+ V + P I Y +++ +LW++ ++
Sbjct: 42 TKEVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGG 100
Query: 153 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 212
GSA DL+ + E IA IL+ +LK LDY+H +HR +KA+++L+S G V L+
Sbjct: 101 GSALDLLKP---GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLA 157
Query: 213 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 270
G+ L+ + V F W++PEV++Q+ YD K+DI+S+GITA
Sbjct: 158 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIKQS--AYDFKADIWSLGITAI 206
Query: 271 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTS 330
ELA G P D+ P L + P S
Sbjct: 207 ELAKGEPPNSDLH----------------------PMRVLFLIPKNS------------- 231
Query: 331 TPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
P G S F FVE CL ++P RP+A LL H F + ++ S
Sbjct: 232 -PPTLEGQ---------HSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTS 278
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 108 bits (269), Expect = 1e-23
Identities = 93/326 (28%), Positives = 146/326 (44%), Gaps = 71/326 (21%)
Query: 75 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 134
IG+G + V LAR K +G V V+ ++L + F E+ + + + H N+V
Sbjct: 413 IGEGSTGI--VCLAREKHSGRQVAVKMMDLRKQQRRELLF--NEVVIMRDYQHFNVVEMY 468
Query: 135 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 194
+++ ELWV+ F+ G+ D++ +NE IA + + VL+AL Y+H G +HR
Sbjct: 469 KSYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHR 525
Query: 195 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 252
+K+ IL+++DG+V LS G ++ D PK V W++PEV+ ++
Sbjct: 526 DIKSDSILLTLDGRVKLS---------DFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 576
Query: 253 LQGYDAKSDIYSVGITACELANGHVP-FKDMPATQMLLEKLNGTVPCLLDTSTIPAEELT 311
L Y + DI+S+GI E+ +G P F D P M + L
Sbjct: 577 L--YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM--------------------KRLR 614
Query: 312 MSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSAS 371
SP + NS H+ SP F+E+ L R+P R +A
Sbjct: 615 DSPPPKLKNS-----------------------HKV-SPVLRDFLERMLVRDPQERATAQ 650
Query: 372 TLLNHSFFKQIKRRASEALPELLRPV 397
LL+H F Q LPE L P+
Sbjct: 651 ELLDHPFLLQ------TGLPECLVPL 670
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 108 bits (269), Expect = 1e-23
Identities = 93/326 (28%), Positives = 146/326 (44%), Gaps = 71/326 (21%)
Query: 75 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 134
IG+G + V LAR K +G V V+ ++L + F E+ + + + H N+V
Sbjct: 413 IGEGSTGI--VCLAREKHSGRQVAVKMMDLRKQQRRELLF--NEVVIMRDYQHFNVVEMY 468
Query: 135 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 194
+++ ELWV+ F+ G+ D++ +NE IA + + VL+AL Y+H G +HR
Sbjct: 469 KSYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHR 525
Query: 195 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 252
+K+ IL+++DG+V LS G ++ D PK V W++PEV+ ++
Sbjct: 526 DIKSDSILLTLDGRVKLS---------DFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 576
Query: 253 LQGYDAKSDIYSVGITACELANGHVP-FKDMPATQMLLEKLNGTVPCLLDTSTIPAEELT 311
L Y + DI+S+GI E+ +G P F D P M + L
Sbjct: 577 L--YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM--------------------KRLR 614
Query: 312 MSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSAS 371
SP + NS H+ SP F+E+ L R+P R +A
Sbjct: 615 DSPPPKLKNS-----------------------HKV-SPVLRDFLERMLVRDPQERATAQ 650
Query: 372 TLLNHSFFKQIKRRASEALPELLRPV 397
LL+H F Q LPE L P+
Sbjct: 651 ELLDHPFLLQ------TGLPECLVPL 670
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 108 bits (269), Expect = 1e-23
Identities = 93/326 (28%), Positives = 146/326 (44%), Gaps = 71/326 (21%)
Query: 75 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 134
IG+G + V LAR K +G V V+ ++L + F E+ + + + H N+V
Sbjct: 413 IGEGSTGI--VCLAREKHSGRQVAVKMMDLRKQQRRELLF--NEVVIMRDYQHFNVVEMY 468
Query: 135 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 194
+++ ELWV+ F+ G+ D++ +NE IA + + VL+AL Y+H G +HR
Sbjct: 469 KSYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHR 525
Query: 195 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 252
+K+ IL+++DG+V LS G ++ D PK V W++PEV+ ++
Sbjct: 526 DIKSDSILLTLDGRVKLS---------DFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 576
Query: 253 LQGYDAKSDIYSVGITACELANGHVP-FKDMPATQMLLEKLNGTVPCLLDTSTIPAEELT 311
L Y + DI+S+GI E+ +G P F D P M + L
Sbjct: 577 L--YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM--------------------KRLR 614
Query: 312 MSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSAS 371
SP + NS H+ SP F+E+ L R+P R +A
Sbjct: 615 DSPPPKLKNS-----------------------HKV-SPVLRDFLERMLVRDPQERATAQ 650
Query: 372 TLLNHSFFKQIKRRASEALPELLRPV 397
LL+H F Q LPE L P+
Sbjct: 651 ELLDHPFLLQ------TGLPECLVPL 670
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 103 bits (258), Expect = 2e-22
Identities = 87/318 (27%), Positives = 141/318 (44%), Gaps = 63/318 (19%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
YEL+ +G G V AR TGE V+ I LE + + +Q E+ + K H
Sbjct: 20 YELVQRVGSGTYG--DVYKARNVHTGELAAVKIIKLEP--GDDFSLIQQEIFMVKECKHC 75
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
NIV Y ++++ +LW+ + GS +D+ H ++EL IAY+ + L+ L Y+H
Sbjct: 76 NIVAYFGSYLSREKLWICMEYCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 189 MGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSP 246
G +HR +K ++IL++ G V L+ G+ + ++ ++ + + W++P
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY---------WMAP 184
Query: 247 EVLQ-QNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQ--MLLEKLNGTVPCLLDTS 303
EV + GY+ DI++VGITA EL P D+ + L+ K N P L D +
Sbjct: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKT 244
Query: 304 TIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRN 363
+S FH+FV+ L +N
Sbjct: 245 -------------------------------------------KWSSTFHNFVKIALTKN 261
Query: 364 PDARPSASTLLNHSFFKQ 381
P RP+A LL H+F Q
Sbjct: 262 PKKRPTAERLLTHTFVAQ 279
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 103 bits (258), Expect = 2e-22
Identities = 87/318 (27%), Positives = 141/318 (44%), Gaps = 63/318 (19%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
YEL+ +G G V AR TGE V+ I LE + + +Q E+ + K H
Sbjct: 20 YELVQRVGSGTYG--DVYKARNVHTGELAAVKIIKLEP--GDDFSLIQQEIFMVKECKHC 75
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
NIV Y ++++ +LW+ + GS +D+ H ++EL IAY+ + L+ L Y+H
Sbjct: 76 NIVAYFGSYLSREKLWICMEYCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 189 MGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSP 246
G +HR +K ++IL++ G V L+ G+ + ++ ++ + + W++P
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY---------WMAP 184
Query: 247 EVLQ-QNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQ--MLLEKLNGTVPCLLDTS 303
EV + GY+ DI++VGITA EL P D+ + L+ K N P L D +
Sbjct: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKT 244
Query: 304 TIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRN 363
+S FH+FV+ L +N
Sbjct: 245 -------------------------------------------KWSSTFHNFVKIALTKN 261
Query: 364 PDARPSASTLLNHSFFKQ 381
P RP+A LL H+F Q
Sbjct: 262 PKKRPTAERLLTHTFVAQ 279
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 103 bits (257), Expect = 3e-22
Identities = 88/325 (27%), Positives = 141/325 (43%), Gaps = 66/325 (20%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLF-NH 127
+E++ IGKG V K G V+ ++ + +E + + E ++ + NH
Sbjct: 27 WEIIETIGKGTYG--KVYKVTNKRDGSLAAVKILDPVSDMDEEI---EAEYNILQFLPNH 81
Query: 128 PNIVP-----YRATFIADNELWVVTSFMAYGSAKDLICTHFMDG--MNELAIAYILQGVL 180
PN+V Y+A +LW+V GS +L+ G ++E I+YIL G L
Sbjct: 82 PNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGAL 141
Query: 181 KALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV 240
L ++H+ +HR VK ++IL++ +G V L + + S R+ SV
Sbjct: 142 LGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNT-------SVGT 194
Query: 241 LPWLSPEVL---QQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVP 297
W++PEV+ QQ YDA+ D++S+GITA EL +G P DM + L + P
Sbjct: 195 PFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPP 254
Query: 298 CLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVE 357
LL HP + F+HF+
Sbjct: 255 TLL-----------------------------------------HP--EKWCEEFNHFIS 271
Query: 358 QCLQRNPDARPSASTLLNHSFFKQI 382
QCL ++ + RPS + LL+H F K +
Sbjct: 272 QCLIKDFERRPSVTHLLDHPFIKGV 296
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 103 bits (257), Expect = 3e-22
Identities = 88/325 (27%), Positives = 141/325 (43%), Gaps = 66/325 (20%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLF-NH 127
+E++ IGKG V K G V+ ++ + +E + + E ++ + NH
Sbjct: 27 WEIIETIGKGTYG--KVYKVTNKRDGSLAAVKILDPVSDMDEEI---EAEYNILQFLPNH 81
Query: 128 PNIVP-----YRATFIADNELWVVTSFMAYGSAKDLICTHFMDG--MNELAIAYILQGVL 180
PN+V Y+A +LW+V GS +L+ G ++E I+YIL G L
Sbjct: 82 PNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGAL 141
Query: 181 KALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV 240
L ++H+ +HR VK ++IL++ +G V L + + S R+ SV
Sbjct: 142 LGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNT-------SVGT 194
Query: 241 LPWLSPEVL---QQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVP 297
W++PEV+ QQ YDA+ D++S+GITA EL +G P DM + L + P
Sbjct: 195 PFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPP 254
Query: 298 CLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVE 357
LL HP + F+HF+
Sbjct: 255 TLL-----------------------------------------HP--EKWCEEFNHFIS 271
Query: 358 QCLQRNPDARPSASTLLNHSFFKQI 382
QCL ++ + RPS + LL+H F K +
Sbjct: 272 QCLIKDFERRPSVTHLLDHPFIKGV 296
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 103 bits (256), Expect = 4e-22
Identities = 81/321 (25%), Positives = 141/321 (43%), Gaps = 59/321 (18%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
+ELL +G G V AR T E V+ + L+ + ++ LQ E+ + + HP
Sbjct: 16 FELLQRVGAGTYG--DVYKARDTVTSELAAVKIVKLDP--GDDISSLQQEITILRECRHP 71
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
N+V Y +++ ++ LW+ F GS +++ H + E IAY+ + LK L ++H
Sbjct: 72 NVVAYIGSYLRNDRLWICMEFCGGGSLQEIY--HATGPLEERQIAYVCREALKGLHHLHS 129
Query: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248
G +HR +K +++L+++ G V L+ + + + ++R P W++PEV
Sbjct: 130 QGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPY-------WMAPEV 182
Query: 249 LQ-QNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQ--MLLEKLNGTVPCLLDTSTI 305
+ GY+ D++++GITA EL P + + ML+ K + P L D +
Sbjct: 183 AAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT-- 240
Query: 306 PAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPD 365
++ +FHHF++ L +NP
Sbjct: 241 -----------------------------------------RWTQNFHHFLKLALTKNPK 259
Query: 366 ARPSASTLLNHSFFKQIKRRA 386
RP+A LL H F Q RA
Sbjct: 260 KRPTAEKLLQHPFTTQQLPRA 280
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 102 bits (254), Expect = 7e-22
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 63/352 (17%)
Query: 37 DTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEY 96
D +RK + + E I + ++S P+ Y IG+G TV A TG+
Sbjct: 253 DRQRKKSKMTDEEILE-KLRSIVSVGDPKKK-YTRFEKIGQGASG--TVYTALDIATGQE 308
Query: 97 VTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAK 156
V ++++NL+ + + E+ V + +PNIV Y +++ +ELWVV ++A GS
Sbjct: 309 VAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Query: 157 DLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRS 216
D++ MD E IA + + L+ALD++H +HR +K+ +IL+ +DG V L+
Sbjct: 367 DVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-G 422
Query: 217 NLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGH 276
+ I+ Q +R Y W++PEV+ + + Y K DI+S+GI A E+ G
Sbjct: 423 FCAQITPEQSKRSTMVGTPY------WMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGE 474
Query: 277 VPF-KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPS 335
P+ + P + L NGT EL +P R
Sbjct: 475 PPYLNENPLRALYLIATNGT------------PEL-QNPER------------------- 502
Query: 336 NGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
S F F+ +CL+ + D R SA LL H F K K +S
Sbjct: 503 ------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 542
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 102 bits (254), Expect = 7e-22
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 63/352 (17%)
Query: 37 DTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEY 96
D +RK + + E I + ++S P+ Y IG+G TV A TG+
Sbjct: 259 DRQRKKSKMTDEEILE-KLRSIVSVGDPKKK-YTRFEKIGQGASG--TVYTALDIATGQE 314
Query: 97 VTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAK 156
V ++++NL+ + + E+ V + +PNIV Y +++ +ELWVV ++A GS
Sbjct: 315 VAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 372
Query: 157 DLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRS 216
D++ MD E IA + + L+ALD++H +HR +K+ +IL+ +DG V L+
Sbjct: 373 DVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-G 428
Query: 217 NLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGH 276
+ I+ Q +R Y W++PEV+ + + Y K DI+S+GI A E+ G
Sbjct: 429 FCAQITPEQSKRSTMVGTPY------WMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGE 480
Query: 277 VPF-KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPS 335
P+ + P + L NGT EL +P R
Sbjct: 481 PPYLNENPLRALYLIATNGT------------PEL-QNPER------------------- 508
Query: 336 NGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
S F F+ +CL+ + D R SA LL H F K K +S
Sbjct: 509 ------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 548
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 102 bits (254), Expect = 7e-22
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 63/352 (17%)
Query: 37 DTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEY 96
D +RK + + E I + ++S P+ Y IG+G TV A TG+
Sbjct: 274 DRQRKKSKMTDEEILE-KLRSIVSVGDPKKK-YTRFEKIGQGASG--TVYTALDIATGQE 329
Query: 97 VTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAK 156
V ++++NL+ + + E+ V + +PNIV Y +++ +ELWVV ++A GS
Sbjct: 330 VAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 387
Query: 157 DLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRS 216
D++ MD E IA + + L+ALD++H +HR +K+ +IL+ +DG V L+
Sbjct: 388 DVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-G 443
Query: 217 NLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGH 276
+ I+ Q +R Y W++PEV+ + + Y K DI+S+GI A E+ G
Sbjct: 444 FCAQITPEQSKRSTMVGTPY------WMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGE 495
Query: 277 VPF-KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPS 335
P+ + P + L NGT EL +P R
Sbjct: 496 PPYLNENPLRALYLIATNGT------------PEL-QNPER------------------- 523
Query: 336 NGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
S F F+ +CL+ + D R SA LL H F K K +S
Sbjct: 524 ------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 563
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 102 bits (254), Expect = 7e-22
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 63/352 (17%)
Query: 37 DTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEY 96
D +RK + + E I + ++S P+ Y IG+G TV A TG+
Sbjct: 238 DRQRKKSKMTDEEILE-KLRSIVSVGDPKKK-YTRFEKIGQGASG--TVYTALDIATGQE 293
Query: 97 VTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAK 156
V ++++NL+ + + E+ V + +PNIV Y +++ +ELWVV ++A GS
Sbjct: 294 VAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 351
Query: 157 DLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRS 216
D++ MD E IA + + L+ALD++H +HR +K+ +IL+ +DG V L+
Sbjct: 352 DVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-G 407
Query: 217 NLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGH 276
+ I+ Q +R Y W++PEV+ + + Y K DI+S+GI A E+ G
Sbjct: 408 FCAQITPEQSKRSTMVGTPY------WMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGE 459
Query: 277 VPF-KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPS 335
P+ + P + L NGT EL +P R
Sbjct: 460 PPYLNENPLRALYLIATNGT------------PEL-QNPER------------------- 487
Query: 336 NGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
S F F+ +CL+ + D R SA LL H F K K +S
Sbjct: 488 ------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 527
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 102 bits (254), Expect = 7e-22
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 63/352 (17%)
Query: 37 DTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEY 96
D +RK + + E I + ++S P+ Y IG+G TV A TG+
Sbjct: 238 DRQRKKSKMTDEEILE-KLRSIVSVGDPKKK-YTRFEKIGQGASG--TVYTALDIATGQE 293
Query: 97 VTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAK 156
V ++++NL+ + + E+ V + +PNIV Y +++ +ELWVV ++A GS
Sbjct: 294 VAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 351
Query: 157 DLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRS 216
D++ MD E IA + + L+ALD++H +HR +K+ +IL+ +DG V L+
Sbjct: 352 DVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-G 407
Query: 217 NLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGH 276
+ I+ Q +R Y W++PEV+ + + Y K DI+S+GI A E+ G
Sbjct: 408 FCAQITPEQSKRSTMVGTPY------WMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGE 459
Query: 277 VPF-KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPS 335
P+ + P + L NGT EL +P R
Sbjct: 460 PPYLNENPLRALYLIATNGT------------PEL-QNPER------------------- 487
Query: 336 NGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
S F F+ +CL+ + D R SA LL H F K K +S
Sbjct: 488 ------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 527
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 102 bits (254), Expect = 7e-22
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 63/352 (17%)
Query: 37 DTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEY 96
D +RK + + E I + ++S P+ Y IG+G TV A TG+
Sbjct: 238 DRQRKKSKMTDEEILE-KLRSIVSVGDPKKK-YTRFEKIGQGASG--TVYTALDIATGQE 293
Query: 97 VTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAK 156
V ++++NL+ + + E+ V + +PNIV Y +++ +ELWVV ++A GS
Sbjct: 294 VAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 351
Query: 157 DLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRS 216
D++ MD E IA + + L+ALD++H +HR +K+ +IL+ +DG V L+
Sbjct: 352 DVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-G 407
Query: 217 NLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGH 276
+ I+ Q +R Y W++PEV+ + + Y K DI+S+GI A E+ G
Sbjct: 408 FCAQITPEQSKRSTMVGTPY------WMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGE 459
Query: 277 VPF-KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPS 335
P+ + P + L NGT EL +P R
Sbjct: 460 PPYLNENPLRALYLIATNGT------------PEL-QNPER------------------- 487
Query: 336 NGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 387
S F F+ +CL+ + D R SA LL H F K K +S
Sbjct: 488 ------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 527
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 101 bits (251), Expect = 1e-21
Identities = 85/314 (27%), Positives = 143/314 (45%), Gaps = 55/314 (17%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
Y+LL +G G V AR K +G+ V ++ + +E ++ V+ LQ E+ + K H
Sbjct: 17 YDLLQRLGGGTYG--EVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEILILKTCRHA 72
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
NIV Y +++ +LW+ F GS +D+ ++EL I+Y+ + VL+ L Y+H
Sbjct: 73 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIY--QVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248
+HR +K ++ILI+ G+V L+ + + + R+ P W++PEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPY-------WMAPEV 183
Query: 249 LQQNLQ-GYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPA 307
L+ GY+ DI+S+GITA ELA P D+ ++L
Sbjct: 184 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLF------------------ 225
Query: 308 EELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 367
+T S +P P +S FH+F++ L ++P R
Sbjct: 226 ------------------LMTKSGYQP-----PRLKEKGKWSAAFHNFIKVTLTKSPKKR 262
Query: 368 PSASTLLNHSFFKQ 381
PSA+ +L+H Q
Sbjct: 263 PSATKMLSHQLVSQ 276
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 101 bits (251), Expect = 1e-21
Identities = 85/314 (27%), Positives = 143/314 (45%), Gaps = 55/314 (17%)
Query: 69 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128
Y+LL +G G V AR K +G+ V ++ + +E ++ V+ LQ E+ + K H
Sbjct: 17 YDLLQRLGGGTYG--EVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEILILKTCRHA 72
Query: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188
NIV Y +++ +LW+ F GS +D+ ++EL I+Y+ + VL+ L Y+H
Sbjct: 73 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIY--QVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248
+HR +K ++ILI+ G+V L+ + + + R+ P W++PEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPY-------WMAPEV 183
Query: 249 LQQNLQ-GYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPA 307
L+ GY+ DI+S+GITA ELA P D+ ++L
Sbjct: 184 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLF------------------ 225
Query: 308 EELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 367
+T S +P P +S FH+F++ L ++P R
Sbjct: 226 ------------------LMTKSGYQP-----PRLKEKGKWSAAFHNFIKVTLTKSPKKR 262
Query: 368 PSASTLLNHSFFKQ 381
PSA+ +L+H Q
Sbjct: 263 PSATKMLSHQLVSQ 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,481,146
Number of Sequences: 37866
Number of extensions: 739259
Number of successful extensions: 3756
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 361
Number of HSP's successfully gapped in prelim test: 322
Number of HSP's that attempted gapping in prelim test: 2675
Number of HSP's gapped (non-prelim): 945
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.