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Search of human proteins with 50659100
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50659100 regeneration associated muscle protease isoform b
[Homo sapiens]
(720 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50659100 regeneration associated muscle protease isoform b [H... 1524 0.0
gi|50659098 regeneration associated muscle protease isoform a [H... 1513 0.0
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr... 137 3e-32
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr... 137 5e-32
gi|66347875 complement component 1, r subcomponent [Homo sapiens] 112 9e-25
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr... 101 2e-21
gi|223942069 enterokinase precursor [Homo sapiens] 99 1e-20
gi|4503137 chymotrypsin-like [Homo sapiens] 98 3e-20
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote... 96 2e-19
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei... 96 2e-19
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 93 8e-19
gi|4503635 coagulation factor II preproprotein [Homo sapiens] 91 5e-18
gi|4506115 protein C [Homo sapiens] 90 8e-18
gi|6912724 tolloid-like 2 [Homo sapiens] 90 8e-18
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 89 2e-17
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 89 2e-17
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 89 2e-17
gi|118498350 chymotrypsin B2 [Homo sapiens] 87 4e-17
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 87 4e-17
gi|118498341 chymotrypsin B1 [Homo sapiens] 87 5e-17
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 87 7e-17
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 86 2e-16
gi|22547221 tolloid-like 1 [Homo sapiens] 85 3e-16
gi|7706083 complement component 1, r subcomponent-like precursor... 84 5e-16
gi|148806900 epidermis-specific serine protease-like protein [Ho... 83 1e-15
gi|11415040 matriptase [Homo sapiens] 81 3e-15
gi|4505861 plasminogen activator, tissue isoform 1 preproprotein... 81 4e-15
gi|14702169 plasminogen activator, tissue isoform 3 preproprotei... 81 4e-15
gi|29244926 corin [Homo sapiens] 81 4e-15
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 81 4e-15
>gi|50659100 regeneration associated muscle protease isoform b [Homo
sapiens]
Length = 720
Score = 1524 bits (3945), Expect = 0.0
Identities = 720/720 (100%), Positives = 720/720 (100%)
Query: 1 MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECVCPGKRE 60
MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECVCPGKRE
Sbjct: 1 MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECVCPGKRE 60
Query: 61 VVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGW 120
VVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGW
Sbjct: 61 VVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGW 120
Query: 121 YGGDCMRCGQVLRAPKGQILLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
YGGDCMRCGQVLRAPKGQILLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD
Sbjct: 121 YGGDCMRCGQVLRAPKGQILLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS 240
YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS
Sbjct: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS 240
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI
Sbjct: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
Query: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKACREPKISDLVRRRVL 360
NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKACREPKISDLVRRRVL
Sbjct: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKACREPKISDLVRRRVL 360
Query: 361 PMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGYQHLHTQLQYECISPFYR 420
PMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGYQHLHTQLQYECISPFYR
Sbjct: 361 PMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGYQHLHTQLQYECISPFYR 420
Query: 421 RLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQGLRWPWQAAIYRRTSGVHDGSL 480
RLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQGLRWPWQAAIYRRTSGVHDGSL
Sbjct: 421 RLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQGLRWPWQAAIYRRTSGVHDGSL 480
Query: 481 HKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQS 540
HKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQS
Sbjct: 481 HKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQS 540
Query: 541 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAG 600
LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAG
Sbjct: 541 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAG 600
Query: 601 WNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDI 660
WNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDI
Sbjct: 601 WNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDI 660
Query: 661 CTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIERNMK 720
CTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIERNMK
Sbjct: 661 CTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIERNMK 720
>gi|50659098 regeneration associated muscle protease isoform a [Homo
sapiens]
Length = 737
Score = 1513 bits (3917), Expect = 0.0
Identities = 720/737 (97%), Positives = 720/737 (97%), Gaps = 17/737 (2%)
Query: 1 MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECVCPGKRE 60
MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECVCPGKRE
Sbjct: 1 MELGCWTQLGLTFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECVCPGKRE 60
Query: 61 VVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGW 120
VVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGW
Sbjct: 61 VVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGW 120
Query: 121 YGGDCMRCGQVLRAPKGQILLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
YGGDCMRCGQVLRAPKGQILLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD
Sbjct: 121 YGGDCMRCGQVLRAPKGQILLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS 240
YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS
Sbjct: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS 240
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLE-----------------ERNCSDP 283
SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLE ERNCSDP
Sbjct: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEAGKSKIKASEDSLSVLEERNCSDP 300
Query: 284 GGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 343
GGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI
Sbjct: 301 GGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 360
Query: 344 KACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGY 403
KACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGY
Sbjct: 361 KACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGY 420
Query: 404 QHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQGLRWP 463
QHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQGLRWP
Sbjct: 421 QHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKTQGLRWP 480
Query: 464 WQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVV 523
WQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVV
Sbjct: 481 WQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVV 540
Query: 524 LGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAA 583
LGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAA
Sbjct: 541 LGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAA 600
Query: 584 SRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSV 643
SRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSV
Sbjct: 601 SRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSV 660
Query: 644 TDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLST 703
TDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLST
Sbjct: 661 TDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLST 720
Query: 704 AFTKVLPFKDWIERNMK 720
AFTKVLPFKDWIERNMK
Sbjct: 721 AFTKVLPFKDWIERNMK 737
>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
precursor [Homo sapiens]
Length = 699
Score = 137 bits (346), Expect = 3e-32
Identities = 158/656 (24%), Positives = 256/656 (39%), Gaps = 167/656 (25%)
Query: 107 YVKGFYCAECRAGWY----GGDC-MRCGQVLRAPKGQILLES-----YPLNAHCEWTIHA 156
Y+ G+YC+ CR G+ C + C L + ++ YP ++ C +TI
Sbjct: 160 YIGGYYCS-CRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL 218
Query: 157 KPGFVIQLRFVMLSLEFDYM---CQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSS 213
+ GF++ L+F + D+ C YDY++++ G +++ CG + P PI + S
Sbjct: 219 EEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP----KVLGPFCGEKAPEPISTQSHS 274
Query: 214 LHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCEN 273
+ +LFHSD S G+ SY+ A G C
Sbjct: 275 VLILFHSDNSGENRGWRL-------------------------SYRAA------GNECPE 303
Query: 274 LLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSY-VLSGNEKRT---- 328
L PV+G + + + V C+ Y VL N +
Sbjct: 304 LQP---------PVHGKIEPSQAKYFFKDQ-------VLVSCDTGYKVLKDNVEMDTFQI 347
Query: 329 -CQQNGEWSGKQPIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQS 386
C ++G WS K P C I CR P +L + +
Sbjct: 348 ECLKDGTWSNKIPTCKIVDCRAPG----------------------ELEHGLITFSTRNN 385
Query: 387 APTKKPALPFGDLPMGYQHLHTQLQYECISPFYRRLGSSRR--TCLRTGKWSGRA----- 439
T K ++++Y C P+Y+ L ++ TC G W +
Sbjct: 386 LTTYK----------------SEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSL 429
Query: 440 PSCIPICG----------KIENITAPKTQGLRWPWQAAIYRRTSGVHDGSLHKGAWFLVC 489
P+C+P+CG +I N P +G PW A + S G F C
Sbjct: 430 PTCLPVCGLPKFSRKLMARIFN-GRPAQKGTT-PWIAML----------SHLNGQPF--C 475
Query: 490 SGALVNERTVVVAAHCVTD--------LGKVTMIKTADLKVVLGKFYRDDDRDEKTIQSL 541
G+L+ +V AAHC+ L ++ +D K++LGK +R R ++ Q L
Sbjct: 476 GGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRL--RSDENEQHL 533
Query: 542 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAGW 601
+ LHP YDP + D+A+++LL+ ++ V PICL + + + V+GW
Sbjct: 534 GVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPE----GPQQEGAMVIVSGW 589
Query: 602 NVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDIC 661
R P +TL + +VD C++ + + VT +M CA E D C
Sbjct: 590 GKQFLQRFP----ETLMEIEIPIVDHSTCQKAYAP--LKKKVTRDMICAG-EKEGGKDAC 642
Query: 662 TAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIER 717
++GG R +W+L+G VSW D R ++ + KDWI+R
Sbjct: 643 AGDSGGPMVTLNRERG----QWYLVGTVSWGDDCGKKDRYG-VYSYIHHNKDWIQR 693
Score = 63.9 bits (154), Expect = 5e-10
Identities = 50/156 (32%), Positives = 69/156 (44%), Gaps = 21/156 (13%)
Query: 142 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGN 201
+SYP ++ W I GF I+L F+ +LE Y+C+YDYV+V D Q++ CG
Sbjct: 38 DSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETED----QVLATFCGR 93
Query: 202 E----RPAPIQSI----GSSLHVLFHSDGS--KNFDGFHAIY-----EEITACSSSPCFH 246
E P Q + GS + + F SD S + F GF A Y +E
Sbjct: 94 ETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSC 153
Query: 247 DGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSD 282
D C + G Y C+C GY +N CSD
Sbjct: 154 DHYC-HNYIGGYYCSCRFGYI-LHTDNRTCRVECSD 187
>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
precursor [Homo sapiens]
Length = 728
Score = 137 bits (344), Expect = 5e-32
Identities = 161/662 (24%), Positives = 265/662 (40%), Gaps = 155/662 (23%)
Query: 107 YVKGFYCAECRAGWY----GGDC-MRCGQVLRAPKGQILLES-----YPLNAHCEWTIHA 156
Y+ G+YC+ CR G+ C + C L + ++ YP ++ C +TI
Sbjct: 160 YIGGYYCS-CRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL 218
Query: 157 KPGFVIQLRFVMLSLEFDYM---CQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSS 213
+ GF++ L+F + D+ C YDY++++ G +++ CG + P PI + S
Sbjct: 219 EEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP----KVLGPFCGEKAPEPISTQSHS 274
Query: 214 LHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCEN 273
+ +LFHSD S G+ SY+ A G C
Sbjct: 275 VLILFHSDNSGENRGWRL-------------------------SYRAA------GNECPE 303
Query: 274 LLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSY-VLSGNEKRT---- 328
L PV+G + + + V C+ Y VL N +
Sbjct: 304 LQP---------PVHGKIEPSQAKYFFKDQ-------VLVSCDTGYKVLKDNVEMDTFQI 347
Query: 329 -CQQNGEWSGKQPIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQS 386
C ++G WS K P C I CR P +L + +
Sbjct: 348 ECLKDGTWSNKIPTCKIVDCRAPG----------------------ELEHGLITFSTRNN 385
Query: 387 APTKKPALPFGDLPMGYQHLHTQLQYECISPFYRRLGSSRR--TCLRTGKWSGRA----- 439
T K ++++Y C P+Y+ L ++ TC G W +
Sbjct: 386 LTTYK----------------SEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSL 429
Query: 440 PSCIPICGK--------IENITAPKTQ--GLRWPWQAAIYRRTSGVHDGS-LHKGAWFLV 488
P+C+P CG+ ++ I + GL +PWQA I V D S + WF
Sbjct: 430 PTCLPECGQPSRSLPSLVKRIIGGRNAEPGL-FPWQALIV-----VEDTSRVPNDKWF-- 481
Query: 489 CSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQSLQISAIIL 548
SGAL++ ++ AAH + + T + + V D RD+ + + ++L
Sbjct: 482 GSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVL 541
Query: 549 HPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHI--TVAGWNV--- 603
HP+++ + DIA+++L + + V P+CL L H+ VAGW +
Sbjct: 542 HPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPR---LEPEGPAPHMLGLVAGWGISNP 598
Query: 604 ---LADVRSPGFK--NDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPS 658
+ ++ S G + +D L+ + VV C+ +E SVT+NMFCA +
Sbjct: 599 NVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYY-EGGK 657
Query: 659 DICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTC-SHRLSTAFTKVLPFKDWIER 717
D C ++GG A V F + RW + GLVSW + C S ++ +TKV + DW+
Sbjct: 658 DTCLGDSGG-AFVIFDDLSQ---RWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWE 713
Query: 718 NM 719
M
Sbjct: 714 QM 715
Score = 63.9 bits (154), Expect = 5e-10
Identities = 50/156 (32%), Positives = 69/156 (44%), Gaps = 21/156 (13%)
Query: 142 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGN 201
+SYP ++ W I GF I+L F+ +LE Y+C+YDYV+V D Q++ CG
Sbjct: 38 DSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETED----QVLATFCGR 93
Query: 202 E----RPAPIQSI----GSSLHVLFHSDGS--KNFDGFHAIY-----EEITACSSSPCFH 246
E P Q + GS + + F SD S + F GF A Y +E
Sbjct: 94 ETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSC 153
Query: 247 DGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSD 282
D C + G Y C+C GY +N CSD
Sbjct: 154 DHYC-HNYIGGYYCSCRFGYI-LHTDNRTCRVECSD 187
>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
Length = 705
Score = 112 bits (281), Expect = 9e-25
Identities = 152/658 (23%), Positives = 242/658 (36%), Gaps = 167/658 (25%)
Query: 107 YVKGFYCAECRAGW------YGGDCMRCGQVLRAPKGQILL----ESYPLNAHCEWTIHA 156
YV G++C+ CR G+ + ++ G I SYP + C ++I
Sbjct: 168 YVGGYFCS-CRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRV 226
Query: 157 KPGFVIQLRFVMLSLEFDYM---CQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSS 213
+ G + L+F+ D+ C YD +++ +G+ I CG +RP + + ++
Sbjct: 227 ERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY----ANGKNIGEFCGKQRPPDLDTSSNA 282
Query: 214 LHVLFHSDGSKNFDGFHAIYE-EITACSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCE 272
+ +LF +D S + G+ Y EI C + T + + Y+ Y C+
Sbjct: 283 VDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQ---FRDYFIATCK 339
Query: 273 NLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQN 332
GYQ I G L +S+ CQ +
Sbjct: 340 Q---------------GYQLIEGNQVL-----------------HSFTA------VCQDD 361
Query: 333 GEWSGKQPIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKK 391
G W P C IK C +P+
Sbjct: 362 GTWHRAMPRCKIKDCGQPR----------------------------------------- 380
Query: 392 PALPFGDL----PMGYQHLHTQLQYECISPFYR---RLGSSRR-----TCLRTGKWSG-- 437
LP GD MG ++QY C P+Y+ R GS TC G W
Sbjct: 381 -NLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQ 439
Query: 438 ---RAPSCIPICGKIEN--------ITAPKTQGLRWPWQAAIYRRTSGVHDGSLHKGAWF 486
+ P C+P+CGK N I K + +PWQ + +H
Sbjct: 440 KGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF-----TNIHGRG------- 487
Query: 487 LVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQSLQISAI 546
GAL+ +R ++ AAH + A L V LG + + + + I +
Sbjct: 488 ---GGALLGDRWILTAAHTLYPKEHEAQ-SNASLDVFLG---HTNVEELMKLGNHPIRRV 540
Query: 547 ILHPNY---DPILLDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHIT-VAGWN 602
+HP+Y + + DIA+L+L + + + PICL D T + + V+G+
Sbjct: 541 SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP---DNDTFYDLGLMGYVSGFG 597
Query: 603 VLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDICT 662
V+ + + LR + V + CE + NMFCA P+ D C
Sbjct: 598 VMEEKIA-----HDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAG-HPSLKQDACQ 651
Query: 663 AETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIERNMK 720
++GG+ AV P RW G+VSW CS +TKVL + DWI++ M+
Sbjct: 652 GDSGGVFAVRDPNT----DRWVATGIVSWGIG--CSRGYGF-YTKVLNYVDWIKKEME 702
Score = 40.4 bits (93), Expect = 0.006
Identities = 43/175 (24%), Positives = 69/175 (39%), Gaps = 36/175 (20%)
Query: 144 YPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNER 203
YP N I G+ ++L F LE C YDYV++ + D + + R CG +
Sbjct: 38 YPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCG-QL 92
Query: 204 PAPI---------QSIGSSLHVLFHSDGSKN-------FDGFHAIYE--EITACSS---- 241
+P+ S G+ + + FH+D S + GF A Y+ ++ C+S
Sbjct: 93 GSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKL 152
Query: 242 ------SPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGY 290
C H + G Y C+C GY Q + + S+ +GY
Sbjct: 153 GEEDPQPQCQH---LCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGY 204
>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
precursor [Homo sapiens]
Length = 686
Score = 101 bits (252), Expect = 2e-21
Identities = 145/644 (22%), Positives = 226/644 (35%), Gaps = 156/644 (24%)
Query: 107 YVKGFYCAECRAGWY------GGDCMRCGQVLRAPKGQILLESYPLN----AHCEWTIHA 156
++ GFYC+ CRAG+ + GQV G++ YP + C ++I
Sbjct: 159 HLGGFYCS-CRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISL 217
Query: 157 KPGFVIQLRFVM---LSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSS 213
+ GF + L FV + + +C YD+++++ G CG P I++ ++
Sbjct: 218 EEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPF----CGKTLPHRIETKSNT 273
Query: 214 LHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCEN 273
+ + F +D S + G+ Y ++ PC +
Sbjct: 274 VTITFVTDESGDHTGWKIHYTS----TAQPCPY--------------------------- 302
Query: 274 LLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNE------KR 327
P P NG+ ++ S FC Y L
Sbjct: 303 ---------PMAPPNGHVSPVQAKYILKDSF-------SIFCETGYELLQGHLPLKSFTA 346
Query: 328 TCQQNGEWSGKQPIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQS 386
CQ++G W P C I C P DL RV + +
Sbjct: 347 VCQKDGSWDRPMPACSIVDCGPP--DDLPSGRV-----------------------EYIT 381
Query: 387 APTKKPALPFGDLPMGYQHLHTQLQYECISPFYR-RLGSSRRTCLRTGKWSGRA-----P 440
P G +QY C FY ++ + C G W+ P
Sbjct: 382 GP-------------GVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLP 428
Query: 441 SCIPICGKIENITAPKTQGLR------WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALV 494
C P+CG T + G + +PWQ I T+ +GAL+
Sbjct: 429 VCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTA---------------AGALL 473
Query: 495 NERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQSLQISAIILHPNYDP 554
+ V+ AAH V + + L + +G R + A+ +H Y
Sbjct: 474 YDNWVLTAAHAVYEQKH----DASALDIRMGTLKRLSPHYTQAWSE----AVFIHEGYTH 525
Query: 555 IL-LDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAGWNVLADVRSPGFK 613
D DIA++KL +K I++ + PICL S + T +GW + GF
Sbjct: 526 DAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWG----LTQRGFL 581
Query: 614 NDTLRSGVVSVVDSLLCEEQHEDHGIP-VSVTDNMFCASWEPTAPSDICTAETGGIAAVS 672
L + +VD C +E P SVT NM CA E + D C ++GG A+
Sbjct: 582 ARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLE-SGGKDSCRGDSGG--ALV 638
Query: 673 FPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIE 716
F S RW + G+VSW +TKV+ + WIE
Sbjct: 639 F--LDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIE 680
Score = 71.6 bits (174), Expect = 2e-12
Identities = 50/147 (34%), Positives = 72/147 (48%), Gaps = 29/147 (19%)
Query: 152 WTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE----RPAP- 206
WT+ A PG+ ++L F LE ++C+YD+V++ G +++ +CG E AP
Sbjct: 47 WTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQESTDTERAPG 102
Query: 207 ---IQSIGSSLHVLFHSDGS--KNFDGFHAIY--EEITACSSSP-----CFHDGTCVLDK 254
S+GSSL + F SD S K F GF A Y E+I C +P C H +
Sbjct: 103 KDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHH---CHNH 159
Query: 255 AGSYKCACLAGYTGQRCENLLEERNCS 281
G + C+C AGY R +R CS
Sbjct: 160 LGGFYCSCRAGYVLHR-----NKRTCS 181
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 99.0 bits (245), Expect = 1e-20
Identities = 133/580 (22%), Positives = 223/580 (38%), Gaps = 115/580 (19%)
Query: 143 SYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 202
SYP A C W ++A+ G IQL F EFD D VE+RDG+ D ++ G
Sbjct: 545 SYPNLAFCVWILNAQKGKNIQLHFQ----EFDLENINDVVEIRDGEEADSLLLAVYTG-- 598
Query: 203 RPAPIQSIGSSLH---VLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGSYK 259
P P++ + S+ + VL ++ GF A + + +H G KA ++
Sbjct: 599 -PGPVKDVFSTTNRMTVLLITNDVLARGGFKANF--------TTGYHLGIPEPCKADHFQ 649
Query: 260 CA---CLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCN 316
C C+ C+ L + SD V + T GL+ R I
Sbjct: 650 CKNGECVP--LVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTA----- 702
Query: 317 NSYVLSGNEKRTCQQNGEWSGKQPICIKACREPKISDLVRRRVLPMQVQSRETPLHQLYS 376
C +N +C ++L + + P+
Sbjct: 703 ------------CAENWTTQISNDVC---------------QLLGLGSGNSSKPIFSTDG 735
Query: 377 AAFSKQKLQSAPTKKPALPFGDLPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWS 436
F K L +AP HL +C+ RL + ++C
Sbjct: 736 GPFVK--LNTAPDG--------------HLILTPSQQCLQDSLIRLQCNHKSC------- 772
Query: 437 GRAPSCIPICGKIENITAPKTQGLRWPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNE 496
G+ + I KI + K WPW +Y + G L +C +LV+
Sbjct: 773 GKKLAAQDITPKIVGGSNAKEGA--WPWVVGLY------YGGRL-------LCGASLVSS 817
Query: 497 RTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPIL 556
+V AAHCV ++ + +LG + + +T+ L I I+++P+Y+
Sbjct: 818 DWLVSAAHCVYGRN----LEPSKWTAILGLHMKSNLTSPQTVPRL-IDEIVINPHYNRRR 872
Query: 557 LDADIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAGWNVLADVRSPGFKNDT 616
D DIA++ L K + +QPICL + + + ++AGW V G +
Sbjct: 873 KDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGR--NCSIAGWGT---VVYQGTTANI 927
Query: 617 LRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGR 676
L+ V ++ + C++Q ++ ++T+NM CA +E D C ++GG P
Sbjct: 928 LQEADVPLLSNERCQQQMPEY----NITENMICAGYE-EGGIDSCQGDSGG------PLM 976
Query: 677 ASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIE 716
RW L G+ S+ Y +R + +V F +WI+
Sbjct: 977 CQENNRWFLAGVTSFGYKCALPNR-PGVYARVSRFTEWIQ 1015
>gi|4503137 chymotrypsin-like [Homo sapiens]
Length = 264
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/256 (28%), Positives = 119/256 (46%), Gaps = 41/256 (16%)
Query: 462 WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLK 521
WPWQ ++ + +SG H C G+L+++ VV AAHC G+
Sbjct: 45 WPWQVSL-QDSSGFH-----------FCGGSLISQSWVVTAAHCNVSPGRHF-------- 84
Query: 522 VVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICL 581
VVLG++ R + + +Q L +S I HP+++ ++ D+ +LKL A+ +TR+ P+CL
Sbjct: 85 VVLGEYDRSSNAEP--LQVLSVSRAITHPSWNSTTMNNDVTLLKLASPAQYTTRISPVCL 142
Query: 582 AASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPV 641
A+S + T + GW L+ V + L+ + +V C +
Sbjct: 143 ASSNEALT--EGLTCVTTGWGRLSGVGN--VTPAHLQQVALPLVTVNQCRQYWGS----- 193
Query: 642 SVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRL 701
S+TD+M CA A + C ++GG P W L+G+VSW K C+ R
Sbjct: 194 SITDSMICAG---GAGASSCQGDSGG------PLVCQKGNTWVLIGIVSWG-TKNCNVRA 243
Query: 702 STAFTKVLPFKDWIER 717
+T+V F WI +
Sbjct: 244 PAVYTRVSKFSTWINQ 259
>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 95.5 bits (236), Expect = 2e-19
Identities = 81/258 (31%), Positives = 115/258 (44%), Gaps = 49/258 (18%)
Query: 463 PWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKV 522
P+QAA+Y TSG L+C G L++ V+ AAHC K +L+V
Sbjct: 34 PYQAALY--TSG-----------HLLCGGVLIHPLWVLTAAHC----------KKPNLQV 70
Query: 523 VLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLA 582
LGK + R+ QS + A+I HP+YD D DI +L+L A++S +QP+ L
Sbjct: 71 FLGK-HNLRQRESSQEQSSVVRAVI-HPDYDAASHDQDIMLLRLARPAKLSELIQPLPL- 127
Query: 583 ASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVS 642
RD S + HI GW AD P DT++ + +V CE H P
Sbjct: 128 -ERDCSANTTSCHI--LGWGKTADGDFP----DTIQCAYIHLVSREECE-----HAYPGQ 175
Query: 643 VTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLS 702
+T NM CA E D C ++GG HL GLVSW S
Sbjct: 176 ITQNMLCAGDEKYG-KDSCQGDSGGPLVCGD----------HLRGLVSWGNIPCGSKEKP 224
Query: 703 TAFTKVLPFKDWIERNMK 720
+T V + +WI++ ++
Sbjct: 225 GVYTNVCRYTNWIQKTIQ 242
>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 95.5 bits (236), Expect = 2e-19
Identities = 81/258 (31%), Positives = 115/258 (44%), Gaps = 49/258 (18%)
Query: 463 PWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKV 522
P+QAA+Y TSG L+C G L++ V+ AAHC K +L+V
Sbjct: 34 PYQAALY--TSG-----------HLLCGGVLIHPLWVLTAAHC----------KKPNLQV 70
Query: 523 VLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLA 582
LGK + R+ QS + A+I HP+YD D DI +L+L A++S +QP+ L
Sbjct: 71 FLGK-HNLRQRESSQEQSSVVRAVI-HPDYDAASHDQDIMLLRLARPAKLSELIQPLPL- 127
Query: 583 ASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVS 642
RD S + HI GW AD P DT++ + +V CE H P
Sbjct: 128 -ERDCSANTTSCHI--LGWGKTADGDFP----DTIQCAYIHLVSREECE-----HAYPGQ 175
Query: 643 VTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLS 702
+T NM CA E D C ++GG HL GLVSW S
Sbjct: 176 ITQNMLCAGDEKYG-KDSCQGDSGGPLVCGD----------HLRGLVSWGNIPCGSKEKP 224
Query: 703 TAFTKVLPFKDWIERNMK 720
+T V + +WI++ ++
Sbjct: 225 GVYTNVCRYTNWIQKTIQ 242
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 93.2 bits (230), Expect = 8e-19
Identities = 66/223 (29%), Positives = 95/223 (42%), Gaps = 54/223 (24%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L A G IL +P + HCEW I AKPG I++ F E +Y D +E
Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNY----DTLE 814
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
VRDG +I G + P + S G+ +++LF +D S++ GF YE +T
Sbjct: 815 VRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVT------ 868
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
LE +C DPG PVNG++ +G
Sbjct: 869 -------------------------------LESDSCLDPGIPVNGHR---------HGG 888
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKAC 346
I + V+F C+ Y LS +E C++N +W+ P C C
Sbjct: 889 DFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALC 931
Score = 80.5 bits (197), Expect = 5e-15
Identities = 69/228 (30%), Positives = 93/228 (40%), Gaps = 63/228 (27%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAK-PGFVIQLRFVMLSLEFDYMCQYDYV 182
CG LR P G I +YP+ NAHC W I P VI+L F EF+ YD +
Sbjct: 412 CGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFE----EFELERGYDTL 467
Query: 183 EVRD----GDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITA 238
V D GD R ++ + G+ P I S+ + + + SD S GF A+Y+EI
Sbjct: 468 TVGDAGKVGDTRS--VLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEI-- 523
Query: 239 CSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPG 298
E+ C DPG P Y K TG
Sbjct: 524 -------------------------------------EKGGCGDPGIP--AYGKRTGSSF 544
Query: 299 LINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKAC 346
L G ++F C ++ L G TCQQN +WSG +P C+ +C
Sbjct: 545 L-------HGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSC 585
Score = 74.3 bits (181), Expect = 4e-13
Identities = 83/313 (26%), Positives = 115/313 (36%), Gaps = 87/313 (27%)
Query: 48 YDQIECVCPGKREVVGYTIPCCRNEENECDSCLIH---PGCTIF-ENCKSCRNGS---WG 100
+D ++C PG GY I R+E + D+ +++ PG + N +C +G W
Sbjct: 1213 FDLVKCEDPGIPNY-GYRI---RDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWD 1268
Query: 101 GTLDDFYVKGFYCAECRAGWYGGDCMRCGQVLRAPKGQILLESYPL----NAHCEWTIHA 156
L AEC GQ+ A G+IL YP N HC W I A
Sbjct: 1269 KPLPSCI------AECG-----------GQIHAATSGRILSPGYPAPYDNNLHCTWIIEA 1311
Query: 157 KPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHV 216
PG I L F++ FD +D ++V DG ++K G+ P I S +SL +
Sbjct: 1312 DPGKTISLHFIV----FDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTL 1367
Query: 217 LFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLE 276
F SD + GF + A +
Sbjct: 1368 QFDSDFFISKSGFSIQFSTSIAAT------------------------------------ 1391
Query: 277 ERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE-- 334
C+DPG P NG + G + G V+F C+ Y L G K TC Q
Sbjct: 1392 ---CNDPGMPQNGTR---------YGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRF 1439
Query: 335 -WSGKQPICIKAC 346
W P CI AC
Sbjct: 1440 FWQPDPPTCIAAC 1452
Score = 72.8 bits (177), Expect = 1e-12
Identities = 68/224 (30%), Positives = 99/224 (44%), Gaps = 33/224 (14%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG LR I +P NA C WTI A+PG I L F LE YD++E
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFLE 263
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+ + + G P+P+ S + L + F SD + GF+A ++ A
Sbjct: 264 ISGTEAPSIWL----TGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELK- 318
Query: 244 CFHDGTCVL-DKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
G +L K GS+K + L+ Q L+ + C DPG P NG +
Sbjct: 319 --SRGVKMLPSKDGSHKNSVLS----QGGVALVSDM-CPDPGIPENGRR--------AGS 363
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE----WSGKQPIC 342
+++G V F C ++YVL G++ TCQ+ E WS +PIC
Sbjct: 364 DFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPIC 407
Score = 67.0 bits (162), Expect = 6e-11
Identities = 53/227 (23%), Positives = 84/227 (37%), Gaps = 60/227 (26%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L P G IL +YP C+W + P FVI L F ++E YD++
Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNME----PSYDFLH 1507
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+ +G++ + +I G++ P I+S G+SL + F SD S GF ++E
Sbjct: 1508 IYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKE-------- 1559
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
C DPG +NG + G
Sbjct: 1560 -------------------------------KPREACFDPGNIMNGTRV---------GT 1579
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE----WSGKQPICIKAC 346
K+G+ +++ C++ Y + TC + W P C C
Sbjct: 1580 DFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNAPC 1626
Score = 64.7 bits (156), Expect = 3e-10
Identities = 56/180 (31%), Positives = 68/180 (37%), Gaps = 52/180 (28%)
Query: 280 CSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQ 339
C DPG P G Q + R ++G+ V F C Y + G+ RTC N WSG Q
Sbjct: 3217 CPDPGTPHFGIQN--------SSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQ 3268
Query: 340 PICI-KACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGD 398
CI ACR+P ETP H A D
Sbjct: 3269 TECIPHACRQP------------------ETPAHADVRAI-------------------D 3291
Query: 399 LP-MGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIENITAPKT 457
LP GY L Y C F+ GS RTC KW+G++P C + N T KT
Sbjct: 3292 LPTFGY-----TLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKT 3346
Score = 64.3 bits (155), Expect = 4e-10
Identities = 59/221 (26%), Positives = 84/221 (38%), Gaps = 60/221 (27%)
Query: 134 APKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDN 189
A G IL +YP N +C W I ++PG I L F +FD Q+D++ V+D
Sbjct: 591 ASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFN----DFDVEPQFDFLAVKDDGI 646
Query: 190 RDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGT 249
D ++ GNE P+ + S G + + F SD S GF+ Y
Sbjct: 647 SDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITY---------------- 690
Query: 250 CVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGT 309
+ C DPG P+NG + G +G+
Sbjct: 691 -----------------------TTFGQNECHDPGIPINGRR---------FGDRFLLGS 718
Query: 310 VVSFFCNNSYV-LSGNEKRTC---QQNGEWSGKQPICIKAC 346
VSF C++ +V G+E TC N WS P C C
Sbjct: 719 SVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPC 759
Score = 62.8 bits (151), Expect = 1e-09
Identities = 55/223 (24%), Positives = 82/223 (36%), Gaps = 60/223 (26%)
Query: 128 CGQVLRAPKGQI----LLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +++ P G I YP A+C W I IQL F +LE D+ D +
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDF----DILS 87
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
V DG + G + R+ G + P+ I S GS L + F +D + + GF A+YE
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYE--------- 138
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
+L C +PG + G+++G
Sbjct: 139 ------------------------------VLPSHTCGNPGEILK---------GVLHGT 159
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTC----QQNGEWSGKQPIC 342
IG + + C Y+L G+ TC W P C
Sbjct: 160 RFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/225 (26%), Positives = 84/225 (37%), Gaps = 58/225 (25%)
Query: 128 CGQVLRAPKGQILLE----SYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L G IL SYP N C W I G+ ++F+ S E +D++E
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTE----ANHDFLE 2030
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+++G +I + G + PA + S + F+SD S+N GF Y+
Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQ--------- 2081
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
Y Q C DP NGY +IN
Sbjct: 2082 ---------------------AYELQNC---------PDPPPFQNGY--------MINSD 2103
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQ--NGEWSGKQPICIKAC 346
++ +G VSF C Y+L G+ TCQ N W+ P C C
Sbjct: 2104 YS-VGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPC 2147
Score = 60.1 bits (144), Expect = 7e-09
Identities = 43/170 (25%), Positives = 63/170 (37%), Gaps = 49/170 (28%)
Query: 280 CSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQ 339
C PG P +G+ NG + VV+F CN Y+L G + C+ NG+WS
Sbjct: 2739 CGHPGNPAHGFT---------NGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPL 2789
Query: 340 PIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGD 398
P C + C +P F + ++ +
Sbjct: 2790 PTCRVVNCSDP----------------------------GFVENAIRHGQQ--------N 2813
Query: 399 LPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
P +++ + Y C FY LGSS TC+ G W P C+ I CG
Sbjct: 2814 FPESFEY-GMSILYHCKKGFY-LLGSSALTCMANGLWDRSLPKCLAISCG 2861
Score = 54.7 bits (130), Expect = 3e-07
Identities = 58/210 (27%), Positives = 79/210 (37%), Gaps = 65/210 (30%)
Query: 263 LAGYTGQRCE-----NLLEER------NCSDPGGPVNGYQKITGGPGLINGRHAKIGTVV 311
L G+ RC+ N+ +ER +C P NG KI G G
Sbjct: 2595 LEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNG-NKI--------GTLTVYGATA 2645
Query: 312 SFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKA-CREPKISDLVRRRVLPMQVQSRETP 370
F CN Y L G+ R C NG WSG + C+ C P +V +
Sbjct: 2646 IFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSP--DPIVNGHI----------- 2692
Query: 371 LHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGYQHLHTQLQYECISPFYRRLGSSRRTCL 430
GD G+ + T + Y+C +P +R +G+S R CL
Sbjct: 2693 -------------------------SGD---GFSYRDT-VVYQC-NPGFRLVGTSVRICL 2722
Query: 431 RTGKWSGRAPSCIPI-CGKIENITAPKTQG 459
+ KWSG+ P C+PI CG N T G
Sbjct: 2723 QDHKWSGQTPVCVPITCGHPGNPAHGFTNG 2752
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/214 (25%), Positives = 81/214 (37%), Gaps = 32/214 (14%)
Query: 256 GSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFC 315
GS C+A R +C PG P N ++ G G VV + C
Sbjct: 2836 GSSALTCMANGLWDRSLPKCLAISCGHPGVPANA---------VLTGELFTYGAVVHYSC 2886
Query: 316 NNSYVLSGNEKRTCQQNGEWSGKQPICI----KACREP-------KISDLVRRRVL---- 360
S L GN+ R CQ++ WSG P C C +P ++ D + + L
Sbjct: 2887 RGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFS 2946
Query: 361 -PMQVQSRETPLHQ-LYSAAFS--KQKLQSAPTKKPALPFGDLPMGYQHL--HTQLQYEC 414
M Q R +P L + ++S + ++ P P + + + + + Y C
Sbjct: 2947 CEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYAC 3006
Query: 415 ISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
Y+ G R C G W+G AP C I CG
Sbjct: 3007 WEG-YKTSGLMTRHCTANGTWTGTAPDCTIISCG 3039
Score = 50.8 bits (120), Expect = 4e-06
Identities = 50/220 (22%), Positives = 77/220 (35%), Gaps = 45/220 (20%)
Query: 256 GSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFC 315
GS + CL + + + E +C +PG P NG I G++ + V + C
Sbjct: 2955 GSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGM--IVSSDGIL------FSSSVIYAC 3006
Query: 316 NNSYVLSGNEKRTCQQNGEWSGKQPIC-IKACREP------------------------- 349
Y SG R C NG W+G P C I +C +P
Sbjct: 3007 WEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNP 3066
Query: 350 -KISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGYQHLHT 408
+ + V + R P + A Q P + + D G +
Sbjct: 3067 GYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCP---QPPPVQNGTVEGSDFRWG-----S 3118
Query: 409 QLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
+ Y C+ Y+ S+ +C G W G P C+P+ CG
Sbjct: 3119 SISYSCMDG-YQLSHSAILSCEGRGVWKGEIPQCLPVFCG 3157
Score = 50.1 bits (118), Expect = 7e-06
Identities = 48/217 (22%), Positives = 74/217 (34%), Gaps = 58/217 (26%)
Query: 136 KGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRD 191
+G IL YP N +C W I G IQ++ + + E + +D +E+ DG +
Sbjct: 1811 RGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLEIHDGGDVT 1866
Query: 192 GQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCV 251
+ G PA + S + L++ F SD S GFH Y+ + +
Sbjct: 1867 APRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAA----------- 1915
Query: 252 LDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVV 311
C +P P N + G + V+
Sbjct: 1916 ----------------------------CQEPALPSNSIK---------IGDRYMVNDVL 1938
Query: 312 SFFCNNSYVLSGNEKRTCQQN--GEWSGKQPICIKAC 346
SF C Y L G +C W+ P+CI C
Sbjct: 1939 SFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/228 (22%), Positives = 84/228 (36%), Gaps = 62/228 (27%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG ++ G +L + YP + +C WTI G +Q+ F LE +DY+
Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE----SSHDYLL 986
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQS--IGS-SLHVLFHSDGSKNFDGFHAIYEEITACS 240
+ + D + + R+ G+ P I++ G+ + + F SD S +++GF+ + E
Sbjct: 987 ITE-DGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSE----- 1040
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
+ C DPG P +
Sbjct: 1041 ----------------------------------YDLEPCDDPGVPAFSRR--------- 1057
Query: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE--WSGKQPICIKAC 346
G H +G ++F C Y L G K TC G WS P C+ C
Sbjct: 1058 IGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAEC 1105
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 29/184 (15%)
Query: 279 NCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRT--CQQNGEWS 336
+C DPG NG Q G VS+ CN YV+ T C ++G W+
Sbjct: 3037 SCGDPGTLANGIQF---------GTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWN 3087
Query: 337 GKQPICIKA-CREP-------------KISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQ 382
+P+C C +P + + + S L + +
Sbjct: 3088 PSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGE 3147
Query: 383 KLQSAPT--KKPALPFGDLPMGYQHLH-TQLQYECISPFYRRLGSSRRTCLRTGKWSGRA 439
Q P P +P G + +++ ++C SPF +GSSRR C G WSG
Sbjct: 3148 IPQCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFIL-VGSSRRVCQADGTWSGIQ 3206
Query: 440 PSCI 443
P+CI
Sbjct: 3207 PTCI 3210
Score = 42.4 bits (98), Expect = 0.002
Identities = 58/271 (21%), Positives = 92/271 (33%), Gaps = 86/271 (31%)
Query: 104 DDFYVKGFYCAECRAGW--YGGDCMRC---------------------GQVLRAPKGQIL 140
DDF + F +C G+ G D + C +V G IL
Sbjct: 2275 DDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVIL 2334
Query: 141 LESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIK 196
YP N C W+I +P + I + FV F Q+D +EV DG + ++
Sbjct: 2335 SPGYPGNYFNSQTCSWSIKVEPNYNITI-FVDT---FQSEKQFDALEVFDGSSGQSPLLV 2390
Query: 197 RVCGNE-RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKA 255
+ GN + S + L++ + +D + + GF Y A
Sbjct: 2391 VLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRY---------------------A 2429
Query: 256 GSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFC 315
Y CS NG G++N +G+ V +FC
Sbjct: 2430 APY---------------------CSLTHPLKNG--------GILNRTAGAVGSKVHYFC 2460
Query: 316 NNSYVLSGNEKRTCQQNG----EWSGKQPIC 342
Y + G+ TC++N +W P+C
Sbjct: 2461 KPGYRMVGHSNATCRRNPLGMYQWDSLTPLC 2491
Score = 42.4 bits (98), Expect = 0.002
Identities = 51/195 (26%), Positives = 73/195 (37%), Gaps = 36/195 (18%)
Query: 279 NCSDPGGPVNGYQKITGGPGLINGRHA-KIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSG 337
NCSDPG N + G N + + G + + C + L G+ TC NG W
Sbjct: 2796 NCSDPGFVENAIRH-----GQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDR 2850
Query: 338 KQPICIK-ACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKL-------QSAPT 389
P C+ +C P + VL ++ + +H YS S+ + Q
Sbjct: 2851 SLPKCLAISCGHPGVP---ANAVLTGELFTYGAVVH--YSCRGSESLIGNDTRVCQEDSH 2905
Query: 390 KKPALPF---------GD--LPMGYQHLHTQLQYECISPF-----YRRLGSSRRTCLRTG 433
ALP GD P L + + + F ++ GS RTCL G
Sbjct: 2906 WSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNG 2965
Query: 434 KWSGRAPSCIPI-CG 447
WSG P C + CG
Sbjct: 2966 SWSGLQPVCEAVSCG 2980
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/152 (25%), Positives = 59/152 (38%), Gaps = 18/152 (11%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG + + G I + YP+ C W I PG + + F +L E DY+
Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE----AVNDYIA 2202
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKN---FDGFHAIYEEITACS 240
V DG +++ + GN S + + + FHSD S FHA ++ C
Sbjct: 2203 VWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAF--QLKKCQ 2260
Query: 241 SSPCFHDGTCVLD----KAGSY-KCACLAGYT 267
P + + + G + K C GYT
Sbjct: 2261 PPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYT 2292
Score = 37.7 bits (86), Expect = 0.038
Identities = 44/228 (19%), Positives = 78/228 (34%), Gaps = 59/228 (25%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +G +L +YP N C ++I FV+ +F + D E
Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALN-----DLAE 1680
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVL-FHSDGSKNFDGFHAIYEEITACSSS 242
+ DG + +++ + G+ + S+ +L F + + GFH +Y+ + S +
Sbjct: 1681 LFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDT 1740
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
+C ++ E R G G
Sbjct: 1741 ---------------------------QCSSVPEPRY------------------GRRIG 1755
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTCQQ----NGEWSGKQPICIKAC 346
G++V F CN Y+L G+ CQ +W+ P C+ C
Sbjct: 1756 SEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPC 1803
Score = 35.0 bits (79), Expect = 0.24
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Query: 382 QKLQSAPTKKPALPFGDLPMGYQHLHTQ-LQYECISPFYRRLGSSRRTCLRTGKWSGRAP 440
Q+++ P +P G LH L +EC + F +G TC + +WSG P
Sbjct: 521 QEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAF-ELVGERVITCQQNNQWSGNKP 579
Query: 441 SCIPIC 446
SC+ C
Sbjct: 580 SCVFSC 585
Score = 33.5 bits (75), Expect = 0.71
Identities = 19/64 (29%), Positives = 34/64 (53%), Gaps = 4/64 (6%)
Query: 387 APTKKPALPFGDLPMGYQHL-HTQLQYECISPFYRRLGSSRRTCL--RTGKWSGRAPSCI 443
A ++PALP + +G +++ + L ++C P Y G S +C+ +W+ +P CI
Sbjct: 1914 AACQEPALPSNSIKIGDRYMVNDVLSFQC-EPGYTLQGRSHISCMPGTVRRWNYPSPLCI 1972
Query: 444 PICG 447
CG
Sbjct: 1973 ATCG 1976
>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
Length = 622
Score = 90.5 bits (223), Expect = 5e-18
Identities = 74/261 (28%), Positives = 116/261 (44%), Gaps = 27/261 (10%)
Query: 463 PWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKV 522
PWQ ++R K L+C +L+++R V+ AAHC+ DL V
Sbjct: 376 PWQVMLFR-----------KSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLV 424
Query: 523 VLGKFYRDDDRDEKTIQSL-QISAIILHPNYD-PILLDADIAILKLLDKARISTRVQPIC 580
+GK R R E+ I+ + + I +HP Y+ LD DIA++KL S + P+C
Sbjct: 425 RIGKHSR--TRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVC 482
Query: 581 LAASRDLSTSFQESHI-TVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGI 639
L ++ Q + V GW L + + + V+ VV+ + E
Sbjct: 483 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKG--QPSVLQVVNLPIVERPVCKDST 540
Query: 640 PVSVTDNMFCASWEPT--APSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTC 697
+ +TDNMFCA ++P D C ++GG F ++ RW+ MG+VSW + C
Sbjct: 541 RIRITDNMFCAGYKPDEGKRGDACEGDSGG----PFVMKSPFNNRWYQMGIVSWG--EGC 594
Query: 698 SHRLSTAF-TKVLPFKDWIER 717
F T V K WI++
Sbjct: 595 DRDGKYGFYTHVFRLKKWIQK 615
>gi|4506115 protein C [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 8e-18
Identities = 73/238 (30%), Positives = 107/238 (44%), Gaps = 27/238 (11%)
Query: 487 LVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKVVLGKFYRDDDRDEKTIQSLQISAI 546
L C L++ V+ AAHC+ + K L V LG++ D R EK L I +
Sbjct: 236 LACGAVLIHPSWVLTAAHCMDESKK--------LLVRLGEY--DLRRWEKWELDLDIKEV 285
Query: 547 ILHPNYDPILLDADIAILKLLDKARISTRVQPICL----AASRDLSTSFQESHITVAGWN 602
+HPNY D DIA+L L A +S + PICL A R+L+ + QE+ +T G++
Sbjct: 286 FVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYH 345
Query: 603 VLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIPVSVTDNMFCASWEPTAPSDICT 662
+ + + L + VV C E + V++NM CA D C
Sbjct: 346 SSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSN-----MVSENMLCAGILGDR-QDACE 399
Query: 663 AETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHRLSTAFTKVLPFKDWIERNMK 720
++GG SF G W L+GLVSW H +TKV + DWI +++
Sbjct: 400 GDSGGPMVASFHG------TWFLVGLVSWGEGCGLLHNYG-VYTKVSRYLDWIHGHIR 450
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 193 QIIKRVCGNERPAPI-QSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCV 251
+ I+ +C E I Q++ +L + SK+ DG + + +S C GTC+
Sbjct: 58 ECIEEICDFEEAKEIFQNVDDTL-----AFWSKHVDGDQCLVLPLEHPCASLCCGHGTCI 112
Query: 252 LDKAGSYKCACLAGYTGQRCENLLEERNCS-DPGGPVN------GYQKITGGPG 298
D GS+ C C +G+ G+ C+ + NCS D GG + G+++ + PG
Sbjct: 113 -DGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPG 165
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 89.7 bits (221), Expect = 8e-18
Identities = 57/156 (36%), Positives = 76/156 (48%), Gaps = 11/156 (7%)
Query: 119 GWYGGDCMRCGQVLRAPKGQILLESYP----LNAHCEWTIHAKPGFVIQLRFVMLSLEFD 174
G++ CG + GQI +YP + C W I GF + L F +E
Sbjct: 455 GFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERH 514
Query: 175 YMCQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA-IY 233
C YDY+EVRDG + +I CG E+P ++S + L + F SDGS N GF A +
Sbjct: 515 DSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFF 574
Query: 234 EEITACS---SSPCFHDGTCVLDKAGSYKCACLAGY 266
+E+ CS C H CV + GSYKCAC GY
Sbjct: 575 KEVDECSWPDHGGCEH--RCV-NTLGSYKCACDPGY 607
Score = 81.3 bits (199), Expect = 3e-15
Identities = 50/151 (33%), Positives = 78/151 (51%), Gaps = 6/151 (3%)
Query: 142 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGN 201
+ YP N +C W + A + I L+F + LE + +C+YD+VEVR G + D ++ R CG+
Sbjct: 638 KEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGS 697
Query: 202 ERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIY---EEITACSSSPCFHDGTCVLDKAGSY 258
E P I S +++ V F SD + + GF A + ++ A + C H+ CV + GSY
Sbjct: 698 ETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHE--CV-NTFGSY 754
Query: 259 KCACLAGYTGQRCENLLEERNCSDPGGPVNG 289
C C GY + +E C+ V G
Sbjct: 755 LCRCRNGYWLHENGHDCKEAGCAHKISSVEG 785
Score = 77.8 bits (190), Expect = 3e-14
Identities = 44/114 (38%), Positives = 55/114 (48%), Gaps = 4/114 (3%)
Query: 125 CMRCGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
C CG+ L+ G YP +HC W I PG I L F + L +C YD
Sbjct: 348 CPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYD 407
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 234
YVEVRDG R ++ R CG++ P P+ S S L V F S + GF A YE
Sbjct: 408 YVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE 461
Score = 75.5 bits (184), Expect = 2e-13
Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 10/156 (6%)
Query: 88 FENCKSCRNGSWGGTLDDFYVKGFYCAECRAGWY----GGDCMR--CGQVLRAPKGQILL 141
F + C + G + G Y CR G++ G DC C + + +G +
Sbjct: 730 FSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLAS 789
Query: 142 ----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKR 197
+ YP C W I + G ++L F +E C YD++E+ DG + I+ R
Sbjct: 790 PNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGR 849
Query: 198 VCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 233
CG+++P P + GSS+ + F+SD S GF A++
Sbjct: 850 FCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH 885
Score = 68.6 bits (166), Expect = 2e-11
Identities = 34/91 (37%), Positives = 49/91 (53%)
Query: 143 SYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 202
+YP A C+W I A+ G+ ++L F +E + C YDY+E DG + + R CG+
Sbjct: 912 NYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSG 971
Query: 203 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 233
I S G SL + F +D + N GFHA Y
Sbjct: 972 PLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/157 (36%), Positives = 77/157 (49%), Gaps = 15/157 (9%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG ++ G I +YP + C W I GF + L F +E C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA-IYEEITACSSS 242
VRDG + +I R CG E+P I+S S L + F SDGS N GF ++E+ CS
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 243 PCFHDGTC---VLDKAGSYKCACLAGY----TGQRCE 272
+ G C L+ GSYKC+C GY +RCE
Sbjct: 555 ---NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
Score = 80.5 bits (197), Expect = 5e-15
Identities = 47/116 (40%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 125 CMRCGQVLRAPKGQILLESYP----LNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
C CG+ L+ G YP + HC W I PG I L F L L +C YD
Sbjct: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEI 236
YVEVRDG R + R CG++ P PI S S L V F S + GF A+YE I
Sbjct: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/108 (34%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L G I + YP N +C W + A + I L+F E + +C+YD+VE
Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA 231
VR G D ++ + CG+E+P I S +++ V F SD + + GF A
Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/157 (36%), Positives = 77/157 (49%), Gaps = 15/157 (9%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG ++ G I +YP + C W I GF + L F +E C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA-IYEEITACSSS 242
VRDG + +I R CG E+P I+S S L + F SDGS N GF ++E+ CS
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 243 PCFHDGTC---VLDKAGSYKCACLAGY----TGQRCE 272
+ G C L+ GSYKC+C GY +RCE
Sbjct: 555 ---NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
Score = 80.5 bits (197), Expect = 5e-15
Identities = 47/116 (40%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 125 CMRCGQVLRAPKGQILLESYP----LNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
C CG+ L+ G YP + HC W I PG I L F L L +C YD
Sbjct: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEI 236
YVEVRDG R + R CG++ P PI S S L V F S + GF A+YE I
Sbjct: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/108 (34%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L G I + YP N +C W + A + I L+F E + +C+YD+VE
Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA 231
VR G D ++ + CG+E+P I S +++ V F SD + + GF A
Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/157 (36%), Positives = 77/157 (49%), Gaps = 15/157 (9%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG ++ G I +YP + C W I GF + L F +E C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA-IYEEITACSSS 242
VRDG + +I R CG E+P I+S S L + F SDGS N GF ++E+ CS
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 243 PCFHDGTC---VLDKAGSYKCACLAGY----TGQRCE 272
+ G C L+ GSYKC+C GY +RCE
Sbjct: 555 ---NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
Score = 80.5 bits (197), Expect = 5e-15
Identities = 47/116 (40%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 125 CMRCGQVLRAPKGQILLESYP----LNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
C CG+ L+ G YP + HC W I PG I L F L L +C YD
Sbjct: 319 CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEI 236
YVEVRDG R + R CG++ P PI S S L V F S + GF A+YE I
Sbjct: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
Score = 78.6 bits (192), Expect = 2e-14
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 10/154 (6%)
Query: 88 FENCKSCRNGSWGGTLDDFYVKGFYCAECRAGWY----GGDCMR--CGQVLRAPKGQILL 141
F + C + G D G Y +CR+G+ DC C + + G I
Sbjct: 701 FSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITS 760
Query: 142 ----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKR 197
+ YP C W I + PG ++L F+ + +E C YD++EV DG + ++ R
Sbjct: 761 PNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGR 820
Query: 198 VCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA 231
CG+++P P+ + GS + + F+SD S GF A
Sbjct: 821 FCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQA 854
Score = 77.0 bits (188), Expect = 6e-14
Identities = 49/158 (31%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L G I + YP N +C W + A + I L+F E + +C+YD+VE
Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA-IYEEITACSSS 242
VR G D ++ + CG+E+P I S +++ V F SD + + GF A + + CS
Sbjct: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKD 710
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNC 280
CV + GSY+C C +G+ ++ +E C
Sbjct: 711 NGGCQQDCV-NTFGSYECQCRSGFVLHDNKHDCKEAGC 747
Score = 70.5 bits (171), Expect = 5e-12
Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 117 RAGWYGGDCMRCGQVLRAP--------KGQILLESYPLNAHCEWTIHAKPGFVIQLRFVM 168
R G+ CG +RA Q +YP CEW I A+ G+ ++L F
Sbjct: 849 RKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQT 908
Query: 169 LSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDG 228
+E + C YDY+E+ DG + + R CG+ P + S G S+ V FHSD + G
Sbjct: 909 FEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKG 968
Query: 229 FHAIY 233
FH Y
Sbjct: 969 FHLRY 973
>gi|118498350 chymotrypsin B2 [Homo sapiens]
Length = 263
Score = 87.4 bits (215), Expect = 4e-17
Identities = 68/257 (26%), Positives = 114/257 (44%), Gaps = 44/257 (17%)
Query: 462 WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLK 521
WPWQ ++ +T F C G+L++E VV AAHC ++T+D+
Sbjct: 45 WPWQVSLQDKTG------------FHFCGGSLISEDWVVTAAHCG--------VRTSDV- 83
Query: 522 VVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICL 581
VV G+F D DE+ IQ L+I+ + +P + + ++ DI +LKL AR S V +CL
Sbjct: 84 VVAGEF--DQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCL 141
Query: 582 AASRDLSTSFQESHI-TVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIP 640
++ D F + GW + D L+ + ++ + C++
Sbjct: 142 PSADD---DFPAGTLCATTGWG--KTKYNANKTPDKLQQAALPLLSNAECKKSWGRR--- 193
Query: 641 VSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHR 700
+TD M CA + C ++GG P + W L+G+VSW +TCS
Sbjct: 194 --ITDVMICAG---ASGVSSCMGDSGG------PLVCQKDGAWTLVGIVSWG-SRTCSTT 241
Query: 701 LSTAFTKVLPFKDWIER 717
+ +V W+++
Sbjct: 242 TPAVYARVAKLIPWVQK 258
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 87.4 bits (215), Expect = 4e-17
Identities = 75/259 (28%), Positives = 116/259 (44%), Gaps = 41/259 (15%)
Query: 462 WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLK 521
WPWQA++ R G H +C GAL+ +R V+ AAHC + +M T
Sbjct: 588 WPWQASLQVR--GRH-----------ICGGALIADRWVITAAHCFQE---DSMASTVLWT 631
Query: 522 VVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICL 581
V LGK +++ + S ++S ++LHP ++ D D+A+L+L S V+P+CL
Sbjct: 632 VFLGKVWQNSRWPGEV--SFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCL 689
Query: 582 AASRDLSTSFQES-HITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIP 640
A S F+ H + GW L R G ++ L+ V ++ LC E +
Sbjct: 690 PAR---SHFFEPGLHCWITGWGAL---REGGPISNALQKVDVQLIPQDLCSEVYR----- 738
Query: 641 VSVTDNMFCASWEPTAPSDICTAETGG-IAAVSFPGRASPEPRWHLMGLVSWSYDKTCSH 699
VT M CA + D C ++GG + + G RW L GLVSW C
Sbjct: 739 YQVTPRMLCAGYR-KGKKDACQGDSGGPLVCKALSG------RWFLAGLVSWGLG--CGR 789
Query: 700 -RLSTAFTKVLPFKDWIER 717
+T++ WI++
Sbjct: 790 PNYFGVYTRITGVISWIQQ 808
>gi|118498341 chymotrypsin B1 [Homo sapiens]
Length = 263
Score = 87.0 bits (214), Expect = 5e-17
Identities = 69/257 (26%), Positives = 114/257 (44%), Gaps = 44/257 (17%)
Query: 462 WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLK 521
WPWQ ++ +T F C G+L++E VV AAHC ++T+D+
Sbjct: 45 WPWQVSLQDKTG------------FHFCGGSLISEDWVVTAAHCG--------VRTSDV- 83
Query: 522 VVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICL 581
VV G+F D DE+ IQ L+I+ + +P + + ++ DI +LKL AR S V +CL
Sbjct: 84 VVAGEF--DQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCL 141
Query: 582 AASRDLSTSFQESHI-TVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIP 640
++ D F + GW + D L+ + ++ + C++
Sbjct: 142 PSADD---DFPAGTLCATTGWG--KTKYNANKTPDKLQQAALPLLSNAECKKSWGRR--- 193
Query: 641 VSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHR 700
+TD M CA + C ++GG P + W L+G+VSW D TCS
Sbjct: 194 --ITDVMICAG---ASGVSSCMGDSGG------PLVCQKDGAWTLVGIVSWGSD-TCSTS 241
Query: 701 LSTAFTKVLPFKDWIER 717
+ +V W+++
Sbjct: 242 SPGVYARVTKLIPWVQK 258
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 86.7 bits (213), Expect = 7e-17
Identities = 64/223 (28%), Positives = 91/223 (40%), Gaps = 54/223 (24%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L +P G IL +P C W I A+PG+ I++ F E +Y D +E
Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNY----DTLE 807
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
VRDG +I G + P + S + L++LF +D S + GF YE IT
Sbjct: 808 VRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETIT------ 861
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
L+ +C DPG PVNG + +G
Sbjct: 862 -------------------------------LQSDHCLDPGIPVNGQR---------HGN 881
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKAC 346
+G +V+F C++ Y LS E C+ N +WS P C C
Sbjct: 882 DFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALC 924
Score = 83.6 bits (205), Expect = 6e-16
Identities = 67/226 (29%), Positives = 92/226 (40%), Gaps = 59/226 (26%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHA-KPGFVIQLRFVMLSLEFDYMCQYDYV 182
C LR P G I ++P+ NAHC W I A P VI+L F EFD YD +
Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFE----EFDLERGYDTL 460
Query: 183 EVRDG--DNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS 240
V DG D ++ + G P I S + +LF +DGS + GF A YEEI
Sbjct: 461 TVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEI---- 516
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
E+ +C DPG P G ++
Sbjct: 517 -----------------------------------EQGSCGDPGIPAYGRRE-------- 533
Query: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKAC 346
G G + F C ++ L G + TCQ+N +WS K+P C+ +C
Sbjct: 534 -GSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578
Score = 83.2 bits (204), Expect = 8e-16
Identities = 66/230 (28%), Positives = 97/230 (42%), Gaps = 24/230 (10%)
Query: 127 RCGQVLRAPKGQILLE----SYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYV 182
+CG + +G IL +YP N C W I GF ++F+ S E ++ DY+
Sbjct: 1967 QCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNH----DYI 2022
Query: 183 EVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
E+R+G +++ R G+E P+ + S V FHSD S+N GF Y+++T
Sbjct: 2023 EIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQI 2082
Query: 243 PCFHDG--TCVLDKAGSYK--CACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPG 298
F G L++ S A CE E + C DP N G
Sbjct: 2083 SSFLRGFDLSELERTNSTPPVAASYVWDLDPGCE-AYELQECPDPEPFAN---------G 2132
Query: 299 LINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQ--NGEWSGKQPICIKAC 346
++ G +G V+F C Y L+G+ TCQ N W P C C
Sbjct: 2133 IVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPC 2182
Score = 71.6 bits (174), Expect = 2e-12
Identities = 61/227 (26%), Positives = 92/227 (40%), Gaps = 60/227 (26%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L P G IL E YP C+W + P +VI L F + +LE YD++
Sbjct: 1445 CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLE----PGYDFLH 1500
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+ DG + +I G++ P I+S +SL + F SD S + GF
Sbjct: 1501 IYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGF-------------- 1546
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
V+D YT EN E +C DPG NG + G
Sbjct: 1547 -------VID------------YT----ENPRE--SCFDPGSIKNGTRV---------GS 1572
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE----WSGKQPICIKAC 346
K+G+ V+++C+ Y + G +C + W+ +P+C C
Sbjct: 1573 DLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPC 1619
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/168 (30%), Positives = 66/168 (39%), Gaps = 52/168 (30%)
Query: 280 CSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQ 339
C+DPG P G Q N + ++G+ V F C Y+L G+ RTC N WSG
Sbjct: 3131 CADPGVPQFGIQN--------NSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP 3182
Query: 340 PICI-KACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGD 398
P C+ CR+P ETP H A D
Sbjct: 3183 PDCVPHHCRQP------------------ETPTHANVGAL-------------------D 3205
Query: 399 LP-MGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI 445
LP MGY L Y C F + GS RTC G W+G+ P C+ +
Sbjct: 3206 LPSMGY-----TLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEV 3248
Score = 68.9 bits (167), Expect = 2e-11
Identities = 64/223 (28%), Positives = 90/223 (40%), Gaps = 32/223 (14%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG LR G I +P NA C WTI A+ G I L F+ LE Y D++E
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGY----DFLE 257
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
V + G PAP+ S + L + F SDG+ GF A Y+
Sbjct: 258 VTGTEGSSLWFT----GASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKS 313
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
+ K S K + L + N+ C DPG P G + G
Sbjct: 314 --RGVKLMPSKDNSQKTSVLTQVGVSQGHNM-----CPDPGIPERGKRL---------GS 357
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE----WSGKQPIC 342
++G+ V F CN Y L G+++ TC + + WS +P+C
Sbjct: 358 DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVC 400
Score = 63.9 bits (154), Expect = 5e-10
Identities = 89/395 (22%), Positives = 138/395 (34%), Gaps = 71/395 (17%)
Query: 130 QVLRAPKGQILLESYPLN----AHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVR 185
++L G IL +SYP + C W + +P + I L E QYD E+
Sbjct: 2359 ELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK----QYDEFEIF 2414
Query: 186 DGDNRDGQIIKRVCGN-ERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPC 244
DG + ++K + GN P + S +S+++ + SD + N GF Y
Sbjct: 2415 DGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAP 2474
Query: 245 FHD---GTCVLDKAGSYKCACLAGY------------------TGQRCENLLEERNCSDP 283
H G GS C AGY L + +C P
Sbjct: 2475 LHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLP 2534
Query: 284 GGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRT--CQQNGEWSGKQ-- 339
P N G++ G+ +GT + C+ Y L + T C G WS +
Sbjct: 2535 EAPKN---------GMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVP 2585
Query: 340 PICIK-ACREPKISDLV-----RRRVLPMQVQSRE------------TPLHQLYSAAFSK 381
P C+ C P +S + R + Q Q + T + A K
Sbjct: 2586 PQCVPVTC--PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGK 2643
Query: 382 QKLQSAPTKKPALPFGDLPM--GYQHLHTQLQYECISPF-----YRRLGSSRRTCLRTGK 434
L + + G+LP+ + T Y + F Y +GS R C+ G
Sbjct: 2644 WSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGL 2703
Query: 435 WSGRAPSCIP-ICGKIENITAPKTQGLRWPWQAAI 468
WSG C+ CG E I G + ++ ++
Sbjct: 2704 WSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSV 2738
Score = 63.5 bits (153), Expect = 6e-10
Identities = 58/224 (25%), Positives = 82/224 (36%), Gaps = 56/224 (25%)
Query: 128 CGQVLRAPKGQI----LLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
C L P G + YP A+C WTI A+ IQL F +LE D+ D +
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDF----DVLS 81
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
V DG + + R+ G + PA I S ++L + SD + + GFHA YE
Sbjct: 82 VFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYE--------- 132
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
+L C +PG NG Q+ G
Sbjct: 133 ------------------------------VLPSHTCGNPGRLPNGIQQ---------GS 153
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKACR 347
+G V + CN + L G+ TC E S + +CR
Sbjct: 154 TFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197
Score = 60.5 bits (145), Expect = 5e-09
Identities = 56/227 (24%), Positives = 84/227 (37%), Gaps = 60/227 (26%)
Query: 128 CGQVLRAP-KGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYV 182
CG +R GQ+L YP N +C WTI A+ G I L F++ FD +D +
Sbjct: 1271 CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLV----FDTEEVHDVL 1326
Query: 183 EVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
+ DG G ++K + G P + S +S+ + F +D + GF + TA S
Sbjct: 1327 RIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATS-- 1384
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
C+DPG P NG + +G
Sbjct: 1385 -------------------------------------CNDPGIPQNGSR---------SG 1398
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTC---QQNGEWSGKQPICIKAC 346
+ G F C+ Y L G+ + +C + W P CI C
Sbjct: 1399 DSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPC 1445
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/225 (26%), Positives = 86/225 (38%), Gaps = 58/225 (25%)
Query: 128 CGQVLRAPKGQILLESYP---LNA-HCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L +G IL +P LN+ +C W I G IQ++ V E ++ D +E
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNW----DSLE 1851
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
V DG + ++ G PA + S + L++ F+SD S + GFH Y+ + S
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSS--- 1908
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
C +P P NG + TG L+N
Sbjct: 1909 ------------------------------------CPEPAVPSNGVK--TGERYLVN-- 1928
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQN--GEWSGKQPICIKAC 346
VVSF C Y L G+ +C W+ P+CI C
Sbjct: 1929 -----DVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQC 1968
Score = 58.2 bits (139), Expect = 3e-08
Identities = 48/170 (28%), Positives = 62/170 (36%), Gaps = 53/170 (31%)
Query: 280 CSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQ 339
C DPG P +G + G GTV+ F C +VL G+ +RTCQ NG WSG Q
Sbjct: 2835 CGDPGIPAHGIRL---------GDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQ 2885
Query: 340 PIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFGD 398
P C + +C P R FS + S
Sbjct: 2886 PECGVISCGNPGTPSNAR--------------------VVFSDGLVFS------------ 2913
Query: 399 LPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
+ + YEC +Y G R C G W+G P C+ I CG
Sbjct: 2914 ---------SSIVYECREGYY-ATGLLSRHCSVNGTWTGSDPECLVINCG 2953
Score = 57.8 bits (138), Expect = 4e-08
Identities = 47/201 (23%), Positives = 77/201 (38%), Gaps = 57/201 (28%)
Query: 134 APKGQILLESYPLN----AHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDN 189
+P G +L +YP + HC W I A+P I L F + +E Q+D++ ++DG
Sbjct: 584 SPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVE----PQFDFLVIKDGAT 639
Query: 190 RDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGT 249
+ ++ GN+ P+ I S G + F +D S GF+ +
Sbjct: 640 AEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF---------------- 683
Query: 250 CVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGT 309
C DPG PVNG + G ++G+
Sbjct: 684 -----------------------TTFRHNECPDPGVPVNGKR---------FGDSLQLGS 711
Query: 310 VVSFFCNNSYV-LSGNEKRTC 329
+SF C+ ++ G+E TC
Sbjct: 712 SISFLCDEGFLGTQGSETITC 732
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/213 (25%), Positives = 80/213 (37%), Gaps = 31/213 (14%)
Query: 256 GSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFC 315
GS C+A E +C P VNG+ ING + V + C
Sbjct: 2692 GSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGH---------INGENYSYRGSVVYQC 2742
Query: 316 NNSYVLSGNEKRTCQQNGEWSGKQPICI-KACREP-------------KISDLVRRRVLP 361
N + L G R CQQ+ WSGK P C+ +C P + +VR +
Sbjct: 2743 NAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIG 2802
Query: 362 MQV----QSRETPLHQLYSAAFSKQKLQSAPT-KKPALPFGDLPMGYQ-HLHTQLQYECI 415
+ +R L ++ + S P +P + +G T +++ C
Sbjct: 2803 KRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCE 2862
Query: 416 SPFYRRLGSSRRTCLRTGKWSGRAPSC-IPICG 447
+ R GSS RTC G WSG P C + CG
Sbjct: 2863 AGHVLR-GSSERTCQANGSWSGSQPECGVISCG 2894
Score = 50.1 bits (118), Expect = 7e-06
Identities = 50/226 (22%), Positives = 82/226 (36%), Gaps = 59/226 (26%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG + +G +L ++P+N + C ++I +PG IQL+ L + D ++
Sbjct: 1098 CGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELS-----EGDVLK 1152
Query: 184 VRDGDNRDGQIIKRVCGNE-RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
V DG+N +++ +E + S SSL + F +D GF +
Sbjct: 1153 VYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS------- 1205
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
E C DPG P GY+ ++
Sbjct: 1206 --------------------------------FELIKCEDPGTPKFGYK--------VHD 1225
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTC--QQNGEWSGKQPICIKAC 346
G+ VSF C+ Y L G+E+ C + W P C+ C
Sbjct: 1226 EGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAEC 1271
Score = 47.8 bits (112), Expect = 4e-05
Identities = 44/189 (23%), Positives = 74/189 (39%), Gaps = 29/189 (15%)
Query: 279 NCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGK 338
+C +PG P N ++ GL+ + + + C Y +G R C NG W+G
Sbjct: 2892 SCGNPGTPSNA--RVVFSDGLV------FSSSIVYECREGYYATGLLSRHCSVNGTWTGS 2943
Query: 339 QPICIKA-CREPKI--------SDLVRRRVLPMQ-VQSRETPLHQLYSAAFSKQKLQSA- 387
P C+ C +P I +D + + Q V H++ + +K + +
Sbjct: 2944 DPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGT 3003
Query: 388 -PTKK-------PALPFGDLPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRA 439
P K P +P G + + + Y C+ + L + TC G W+G
Sbjct: 3004 KPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSL-PAVFTCEGNGSWTGEL 3062
Query: 440 PSCIPI-CG 447
P C P+ CG
Sbjct: 3063 PQCFPVFCG 3071
Score = 45.1 bits (105), Expect = 2e-04
Identities = 50/207 (24%), Positives = 85/207 (41%), Gaps = 33/207 (15%)
Query: 257 SYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCN 316
S C+ +TG E L+ NC DPG P N GL G + V++ C
Sbjct: 2931 SRHCSVNGTWTGSDPECLVI--NCGDPGIPAN---------GLRLGNDFRYNKTVTYQCV 2979
Query: 317 NSYVLSGNEKR--TCQQNGEWSGKQPIC-IKACREPKI--------SDLV-RRRVLPMQV 364
Y++ + +C ++ W+G +P+C C+ P + SD + V +
Sbjct: 2980 PGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACL 3039
Query: 365 QSRETPLHQLY----SAAFSKQKLQSAPT--KKPALPFGDL--PMGYQHLHTQLQYECIS 416
+ + L ++ + +++ + Q P P +P G+ + + + + C
Sbjct: 3040 EGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSY-RSSVSFSCHP 3098
Query: 417 PFYRRLGSSRRTCLRTGKWSGRAPSCI 443
P +GS RR C G WSG PSCI
Sbjct: 3099 PLV-LVGSPRRFCQSDGTWSGTQPSCI 3124
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/228 (21%), Positives = 82/228 (35%), Gaps = 62/228 (27%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG ++ G IL + YP N +C W I G + F LE +DY+
Sbjct: 924 CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLE----SGHDYLL 979
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQS--IGS-SLHVLFHSDGSKNFDGFHAIYEEITACS 240
+ + + Q ++++ G+ PAPI + G+ + V F SD S +++GF+ + E
Sbjct: 980 ITENGSFT-QPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSE----- 1033
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
+ C +P P +K
Sbjct: 1034 ----------------------------------YDLEPCEEPEVPAYSIRK-------- 1051
Query: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTC--QQNGEWSGKQPICIKAC 346
G +G ++F C Y L G + TC + WS P C+ C
Sbjct: 1052 -GLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAEC 1098
Score = 40.0 bits (92), Expect = 0.008
Identities = 43/228 (18%), Positives = 80/228 (35%), Gaps = 59/228 (25%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG G +L +YP N C + + +V+ +F F + D VE
Sbjct: 1619 CGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFA-----FFHTALNDVVE 1673
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQ-SIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
V DG ++ +++ + G+ + + + + + F + G GFH +Y+ + S++
Sbjct: 1674 VHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSAT 1733
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
+C ++ E R G G
Sbjct: 1734 ---------------------------QCSSVPEPRY------------------GKRLG 1748
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTC----QQNGEWSGKQPICIKAC 346
+G +V F CN+ Y L G+ + C +W+ P C+ C
Sbjct: 1749 SDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPC 1796
Score = 35.4 bits (80), Expect = 0.19
Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 4/77 (5%)
Query: 380 SKQKLQSAPTKKPALP-FGDLPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGR 438
S ++++ P +P +G H L++EC P + +G TC + +WS +
Sbjct: 512 SYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFEC-QPAFELVGQKAITCQKNNQWSAK 570
Query: 439 APSCIPICGKIENITAP 455
P C+ C N T+P
Sbjct: 571 KPGCVFSC--FFNFTSP 585
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/223 (28%), Positives = 92/223 (41%), Gaps = 54/223 (24%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG AP G IL +P + +CEW I A+PG I++ F E +Y D +E
Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNY----DVLE 846
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
V DG N ++ G + P + S + +++LF +D S++ +GF YE +T + S
Sbjct: 847 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS- 905
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
C DPG PV+G + G
Sbjct: 906 ------------------------------------CLDPGIPVHGRR---------YGH 920
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKAC 346
IG+ VSF C++ Y LS E C++N WS P C C
Sbjct: 921 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 963
Score = 77.8 bits (190), Expect = 3e-14
Identities = 57/227 (25%), Positives = 91/227 (40%), Gaps = 60/227 (26%)
Query: 128 CGQVLRAPKGQILLES----YPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L G IL + YP + C+WTI +VI L F+ S+E +Y D++
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNY----DFLY 1539
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+ DG + + +I ++ P I+S +++H+ F SDGS ++ GFH Y+
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKL------ 1593
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
+C DPG +NG + G
Sbjct: 1594 ---------------------------------RESCFDPGNIMNGTRL---------GM 1611
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE----WSGKQPICIKAC 346
K+G+ V+++C+ YVL G TC + W+ P C C
Sbjct: 1612 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPC 1658
Score = 76.6 bits (187), Expect = 7e-14
Identities = 69/228 (30%), Positives = 95/228 (41%), Gaps = 33/228 (14%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +R G I S+P NA C WTI A+PG I L F +F +YDY+E
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFT----DFQMEEKYDYLE 296
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+ + + G P PI S + L + F +D + + GF A Y+ A
Sbjct: 297 IEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKS 352
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
K S K + L + NL C DPG P NG + G
Sbjct: 353 --RGFKLFPGKDNSNKFSILNEGGIKTASNL-----CPDPGEPENGKR---------IGS 396
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE----WSGKQPIC-IKAC 346
+G+ V F C+ YVL G + TCQ+ E WS +P+C +K C
Sbjct: 397 DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTC 444
Score = 75.1 bits (183), Expect = 2e-13
Identities = 59/226 (26%), Positives = 87/226 (38%), Gaps = 58/226 (25%)
Query: 127 RCGQVLRAPKGQILLE----SYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYV 182
+CG + G IL +YP + C WTI+ GF + L+FV S E +DY+
Sbjct: 2006 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYL 2061
Query: 183 EVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
EVR G + +I R+ G + P+ + S + FHSD S+N GFH +Y+
Sbjct: 2062 EVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQ-------- 2113
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
+ ++C DP NG+ + G
Sbjct: 2114 -------------------------------AYQLQSCPDPRPFRNGF---------VIG 2133
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTCQQ--NGEWSGKQPICIKAC 346
+G +SF C Y L GN TC + W+ P C C
Sbjct: 2134 NDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALC 2179
Score = 71.2 bits (173), Expect = 3e-12
Identities = 89/353 (25%), Positives = 142/353 (40%), Gaps = 64/353 (18%)
Query: 142 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGN 201
+SYP C W+I + G+ I + FV F ++D ++V DG N ++ + G+
Sbjct: 2372 DSYPNLQMCAWSISVEKGYNITM-FVEF---FQTEKEFDVLQVYDGPNIQSPVLISLSGD 2427
Query: 202 ERPA-PIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGSY-- 258
A I S G + + + +D N GF Y CS+ G + G
Sbjct: 2428 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY-CSTPESPPHGYIISQTGGQLNS 2486
Query: 259 --KCAC-----LAGYTGQRCEN-------------LLEERNCSDPGGPVNGYQKITGGPG 298
+ AC L G + C + +C P P NG G
Sbjct: 2487 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNG--------G 2538
Query: 299 LINGRHAKIGTVVSFFCNNSYVLSGNEKRT--CQQNGEWS--GKQPICIK-ACRE---PK 350
++ + +GT V++FCN+ Y LS E T CQ +G WS K P C+ +C E P
Sbjct: 2539 ILTTDYL-VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPP 2597
Query: 351 ISDLVRRRV--------------LPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPF 396
+ + + + + RE L+S S+ + + P L
Sbjct: 2598 NGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSE--SETRCLAGHCGIPELIV 2655
Query: 397 GDLPMGYQH-LHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
+G + + Y+C +P +R +GSS R C + WSG+ PSC+P+ CG
Sbjct: 2656 NGQVIGENYGYRDTVVYQC-NPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2707
Score = 67.0 bits (162), Expect = 6e-11
Identities = 60/226 (26%), Positives = 86/226 (38%), Gaps = 59/226 (26%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHA-KPGFVIQLRFVMLSLEFDYMCQYDYV 182
CG L+ P G ++P NA C W I A VIQ+ F EFD YD +
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFE----EFDLEIGYDTL 499
Query: 183 EVRDGDNRDGQ--IIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACS 240
+ DG +++ + G+ P I S+ S + + +D S GF Y+EI
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEI---- 555
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
E+ +C DPG P+ G ++ G G
Sbjct: 556 -----------------------------------EKESCGDPGTPLYGIRE---GDGFS 577
Query: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKAC 346
N V+ F C + L G + CQ+N +WS PICI C
Sbjct: 578 NR------DVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPC 617
Score = 67.0 bits (162), Expect = 6e-11
Identities = 59/227 (25%), Positives = 87/227 (38%), Gaps = 60/227 (26%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
C AP G +L YP N +C WTI + PG I L F +FD Q+D++
Sbjct: 617 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFN----DFDLESQFDFLA 672
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
V+DGD+ + I+ G E P+ + S L + F +D S + GF+ Y
Sbjct: 673 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY---------- 722
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
N C DPG P+N + G
Sbjct: 723 -----------------------------NTFGHNECPDPGIPINARR---------FGD 744
Query: 304 HAKIGTVVSFFCNNSYV-LSGNEKRTC-QQNGE--WSGKQPICIKAC 346
+ ++G+ +S C ++ G E TC +G+ WSG P C C
Sbjct: 745 NFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 791
Score = 65.5 bits (158), Expect = 2e-10
Identities = 55/217 (25%), Positives = 79/217 (36%), Gaps = 59/217 (27%)
Query: 137 GQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDG 192
G+IL YP N C W I PG ++ L+F L FD +D + V DG +
Sbjct: 1320 GRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQF----LAFDTEASHDILRVWDGPPEND 1375
Query: 193 QIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVL 252
++K + G+ P I S + + + F +D + GF + A +
Sbjct: 1376 MLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA------------ 1423
Query: 253 DKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVS 312
C DPG P+NG + NG + G V
Sbjct: 1424 ---------------------------CRDPGVPMNGTR---------NGDGREPGDTVV 1447
Query: 313 FFCNNSYVLSGNEKRTCQQNGE---WSGKQPICIKAC 346
F C+ Y L G E+ TC Q W P+CI C
Sbjct: 1448 FQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1484
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/218 (27%), Positives = 83/218 (38%), Gaps = 37/218 (16%)
Query: 256 GSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFC 315
G K C A + + NCSDPG P N ++ I + GTVV + C
Sbjct: 2740 GPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRE-----SKIEHGNFTYGTVVFYDC 2794
Query: 316 NNSYVLSGNEKRTCQQNGEWSGKQPICIKA-CREPKISDLVRRRVLPMQVQSRETPLHQL 374
N Y L G+ CQ NG+W P CI C P + VL + + + +H
Sbjct: 2795 NPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPP---NAVLSGEKYTFGSTVH-- 2849
Query: 375 YSAAFSKQKL-QSAPTKK----------------------PALP-FGDLPMGYQHLHTQL 410
YS + L QS+ T + P P G + +
Sbjct: 2850 YSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTV 2909
Query: 411 QYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
+Y C + + GS RTCL G W+GR P C + CG
Sbjct: 2910 RYACDTGYILH-GSEERTCLANGSWTGRQPECKAVQCG 2946
Score = 60.8 bits (146), Expect = 4e-09
Identities = 57/198 (28%), Positives = 80/198 (40%), Gaps = 30/198 (15%)
Query: 279 NCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYV--LSGNEKRTCQQNGEWS 336
+C DPG P NG L G +G VS+ C Y L+G+ RTC NG WS
Sbjct: 3003 SCGDPGIPANG---------LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWS 3053
Query: 337 GKQPIC--IKACREPKISD------------LVRRRVLPMQVQSRETPLHQLYSAAFSKQ 382
G P C + P+IS+ + P S L + + +S +
Sbjct: 3054 GVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGE 3113
Query: 383 KLQSAP--TKKPALPFGDLPMGYQHLH-TQLQYECISPFYRRLGSSRRTCLRTGKWSGRA 439
Q P P +P G ++ +++ + C PF +GSS R C G WSG +
Sbjct: 3114 VPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFI-LVGSSTRICQADGTWSGSS 3172
Query: 440 PSCI-PICGKIENITAPK 456
P CI P EN P+
Sbjct: 3173 PHCIEPTQTSCENPGVPR 3190
Score = 60.8 bits (146), Expect = 4e-09
Identities = 47/167 (28%), Positives = 66/167 (39%), Gaps = 50/167 (29%)
Query: 277 ERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWS 336
+ +C +PG P +G Q T G ++G+VV F C ++L G+ RTC + WS
Sbjct: 3180 QTSCENPGVPRHGSQNNTFG--------FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS 3231
Query: 337 GKQPICIK-ACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALP 395
G QP CI +C++P ETP H
Sbjct: 3232 GIQPECIPHSCKQP------------------ETPAHANVVGM----------------- 3256
Query: 396 FGDLPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSC 442
DLP H +T L Y C F+ G+ R C W+G+ P C
Sbjct: 3257 --DLP---SHGYT-LIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3297
Score = 60.5 bits (145), Expect = 5e-09
Identities = 54/223 (24%), Positives = 78/223 (34%), Gaps = 60/223 (26%)
Query: 128 CGQVLRAPKGQI----LLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG L+ G I YP A+C W I A+ IQ+ F +LE +Y DY+
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEY----DYLS 120
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
+ DG R+ G P P+ S S + SD + + GF YEE
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEE-------- 172
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
L+ +C +PG P G++ G
Sbjct: 173 -------------------------------LQSSSCGNPGVPPK---------GVLYGT 192
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQN----GEWSGKQPIC 342
+G + + C Y+L G+ + TC N W PIC
Sbjct: 193 RFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
Score = 60.5 bits (145), Expect = 5e-09
Identities = 57/225 (25%), Positives = 84/225 (37%), Gaps = 58/225 (25%)
Query: 128 CGQVLRAPKGQILLESYPL----NAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +L KG IL YP N +C W I G IQ++ V + E + +D ++
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1890
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSP 243
DG + + + G P + S ++L++ F SD S + GFH Y I
Sbjct: 1891 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG------ 1944
Query: 244 CFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGR 303
LD +C +P P +G + G
Sbjct: 1945 --------LD-------------------------SCPEPQTPSSGIK---------IGD 1962
Query: 304 HAKIGTVVSFFCNNSYVLSGNEKRTCQQN--GEWSGKQPICIKAC 346
+G VVSF C+ Y L G+ TC W+ PIC+ C
Sbjct: 1963 RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2007
Score = 58.5 bits (140), Expect = 2e-08
Identities = 62/236 (26%), Positives = 90/236 (38%), Gaps = 35/236 (14%)
Query: 256 GSYKCACLAG--YTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSF 313
GS + CLA +TG++ E + C +PG NG G + V +
Sbjct: 2921 GSEERTCLANGSWTGRQPE--CKAVQCGNPGTTANGKVFRIDG--------TTFSSSVIY 2970
Query: 314 FCNNSYVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKI--------SDLVRRRVLPMQV 364
C Y+LSG R C NG WSG P C I +C +P I D V + +
Sbjct: 2971 SCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMC 3030
Query: 365 QS-----------RETPLHQLYSAAFSKQKLQSAPTKKPALPFGDLPMGYQHLHTQLQYE 413
Q R ++ +S + + PT P + G L + Y
Sbjct: 3031 QPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT-PPQISNGRLEGTNFDWGFSISYI 3089
Query: 414 CISPFYRRLGSSRRTCLRTGKWSGRAPSCIP-ICGKIENITAPKTQGLRWPWQAAI 468
C SP Y + TC+ G WSG P C+P CG K +G + +Q+ +
Sbjct: 3090 C-SPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEV 3144
Score = 56.6 bits (135), Expect = 8e-08
Identities = 46/169 (27%), Positives = 65/169 (38%), Gaps = 55/169 (32%)
Query: 280 CSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQ 339
C DPG P G ++ G+ + VSF CN ++L G+ R CQ +G WSG
Sbjct: 3122 CGDPGIPAQGKRE---------GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSS 3172
Query: 340 PICIK----ACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALP 395
P CI+ +C P + P H + F
Sbjct: 3173 PHCIEPTQTSCENPGV------------------PRHGSQNNTF---------------- 3198
Query: 396 FGDLPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIP 444
G+Q + + +Q+ C + GS+ RTCL WSG P CIP
Sbjct: 3199 ------GFQ-VGSVVQFHCKKGHLLQ-GSTTRTCLPDLTWSGIQPECIP 3239
Score = 53.1 bits (126), Expect = 9e-07
Identities = 48/171 (28%), Positives = 65/171 (38%), Gaps = 50/171 (29%)
Query: 279 NCSDPGGPVNGYQKITGGPGLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGK 338
+C PG P+ G T G G VV+F CN Y++ G K CQ N +WS
Sbjct: 2705 SCGHPGSPIYGR---TSGNGF------NFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP 2755
Query: 339 QPIC-IKACREPKISDLVRRRVLPMQVQSRETPLHQLYSAAFSKQKLQSAPTKKPALPFG 397
P+C + C +P I A SK ++ + G
Sbjct: 2756 PPMCKVVNCSDPGI-------------------------PANSK--------RESKIEHG 2782
Query: 398 DLPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPI-CG 447
+ G T + Y+C +P Y GSS C G+W P CI I CG
Sbjct: 2783 NFTYG-----TVVFYDC-NPGYFLFGSSVLICQPNGQWDKPLPECIMIDCG 2827
Score = 52.0 bits (123), Expect = 2e-06
Identities = 56/228 (24%), Positives = 87/228 (38%), Gaps = 62/228 (27%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +R P G IL E YP + +C WT+ G +Q F LE +DY+
Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE----DHHDYLL 1018
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQS--IGS-SLHVLFHSDGSKNFDGFHAIYEEITACS 240
+ + + Q + R+ G++ P I + G+ + F SD S +++GF+ + E
Sbjct: 1019 ITENGSFT-QPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE----- 1072
Query: 241 SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLI 300
Y + CE DPG P G +
Sbjct: 1073 -------------------------YNLEPCE---------DPGIPQYGSR--------- 1089
Query: 301 NGRHAKIGTVVSFFCNNSYVLSGNEKRTCQQNGE--WSGKQPICIKAC 346
G + IG ++F C++ Y L G + C G WS P C+ C
Sbjct: 1090 IGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1137
Score = 51.2 bits (121), Expect = 3e-06
Identities = 50/228 (21%), Positives = 82/228 (35%), Gaps = 59/228 (25%)
Query: 128 CGQVLRAPKGQILLESYPLNA----HCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +G +L +YP N +C ++I FV+ +FV +D VE
Sbjct: 1658 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL-----HDVVE 1712
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQ-SIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
V DG + ++ + G+ + S G+ + + F S G GFH +Y+ + SS+
Sbjct: 1713 VYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSST 1772
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
+C ++ E R G G
Sbjct: 1773 ---------------------------QCSSVPEPRF------------------GRRIG 1787
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTCQ----QNGEWSGKQPICIKAC 346
+G+ V F CN Y+L G+ C+ +W+ P CI C
Sbjct: 1788 NEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1835
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/226 (20%), Positives = 81/226 (35%), Gaps = 59/226 (26%)
Query: 128 CGQVLRAPKGQILLESYPLNAH----CEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +G +L +YPLN C ++I + G + + +S ++ Q D ++
Sbjct: 1137 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAG-----KGINISARTFHLAQGDVLK 1191
Query: 184 VRDGDNRDGQIIKRVCG-NERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSS 242
+ DG ++ ++ G + R + S + L + F+SD +GF +Y
Sbjct: 1192 IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF------ 1245
Query: 243 PCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGGPVNGYQKITGGPGLING 302
E +C DPG P GY+ I+
Sbjct: 1246 ---------------------------------ELSHCEDPGIPQFGYK--------ISD 1264
Query: 303 RHAKIGTVVSFFCNNSYVLSGNEKRTCQ--QNGEWSGKQPICIKAC 346
+ G+ + + CN Y L G+ C + W P CI C
Sbjct: 1265 QGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAEC 1310
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG + A G I + YP C W + PG I + F +L E YD++
Sbjct: 2179 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTE----PIYDFIT 2234
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSD 221
V DG +++ I + GN + S + + + FHSD
Sbjct: 2235 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD 2272
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 84.7 bits (208), Expect = 3e-16
Identities = 50/144 (34%), Positives = 73/144 (50%), Gaps = 5/144 (3%)
Query: 128 CGQVLRAPKGQILLESYPLN----AHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVE 183
CG +R +GQI +YP + C W I + + L F +E C YDY+E
Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
Query: 184 VRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHA-IYEEITACSSS 242
VRDG + + +I R CG ++P I+S ++L + F SDG+ N GF A ++E C+
Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 243 PCFHDGTCVLDKAGSYKCACLAGY 266
L+ GSY+CAC GY
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGY 605
Score = 82.4 bits (202), Expect = 1e-15
Identities = 50/156 (32%), Positives = 71/156 (45%), Gaps = 10/156 (6%)
Query: 88 FENCKSCRNGSWGGTLDDFYVKGFYCAECRAGWY----GGDCMR--CGQVLRAPKGQILL 141
F + C + G + G Y +CR G+ DC C Q + +P G I
Sbjct: 728 FSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITS 787
Query: 142 ----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKR 197
+ YP C W I A PG I+L F +E C YD++EV DG+ I+ R
Sbjct: 788 PNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGR 847
Query: 198 VCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 233
+CGN+ P P+ + G+ + V F SD S GF A +
Sbjct: 848 LCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
Score = 77.4 bits (189), Expect = 4e-14
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 24/203 (11%)
Query: 110 GFYCAECRAGWYGGDCMR-----CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGF 160
G Y C G+ G R CG +L G I + YP N +C W + A +
Sbjct: 595 GSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQY 654
Query: 161 VIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHS 220
I ++F LE + +C+YDYVE+ G + + ++ + CG E P I S +++ + F S
Sbjct: 655 RISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKS 714
Query: 221 DGSKNFDGFHA-IYEEITACS--SSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEE 277
D + + GF A + + CS + C H+ CV + GSY C C G+ ++ +E
Sbjct: 715 DNTVSKKGFKAHFFSDKDECSKDNGGCQHE--CV-NTMGSYMCQCRNGFVLHDNKHDCKE 771
Query: 278 RNCSDPGGPVNGYQKITGGPGLI 300
C QKI GLI
Sbjct: 772 AECE---------QKIHSPSGLI 785
Score = 76.6 bits (187), Expect = 7e-14
Identities = 40/116 (34%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 125 CMRCGQVLRAPKGQI----LLESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYD 180
C CG+ L+ G + YP HC W + PG I L F + L +C YD
Sbjct: 346 CPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
Query: 181 YVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEI 236
Y+EVRDG R ++ R CG++ P + S S + + F S + GF A+YE I
Sbjct: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
Score = 69.7 bits (169), Expect = 9e-12
Identities = 42/128 (32%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Query: 117 RAGWYGGDCMRCGQVLRAPK--------GQILLESYPLNAHCEWTIHAKPGFVIQLRFVM 168
R G+ CG L+A Q +YP CEW + ++ G ++L F
Sbjct: 876 RKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQT 935
Query: 169 LSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDG 228
+E + C YDYVE+ DG + + R CG+ P I SIG S+ + FH+D + N G
Sbjct: 936 FEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKG 995
Query: 229 FHAIYEEI 236
FH Y+ I
Sbjct: 996 FHIRYKSI 1003
>gi|7706083 complement component 1, r subcomponent-like precursor
[Homo sapiens]
Length = 487
Score = 84.0 bits (206), Expect = 5e-16
Identities = 78/324 (24%), Positives = 128/324 (39%), Gaps = 49/324 (15%)
Query: 409 QLQYECISPFYRRLGSSRRTCLRTGKWSGRAPS-----CIPICGKIENITAPKTQGL--- 460
++Q C P+Y+ + TC G W R C+P+CG+ A L
Sbjct: 190 KVQNHCQEPYYQAAAAGALTCATPGTWKDRQDGEEVLQCMPVCGRPVTPIAQNQTTLGSS 249
Query: 461 -----RWPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMI 515
+PWQA S+H GAL+ +R ++ AAH V V++
Sbjct: 250 RAKLGNFPWQAFT----------SIHGRG-----GGALLGDRWILTAAHTVYPKDSVSLR 294
Query: 516 KTADLKVVLGKFYRDDDRDEKTIQSLQISAIILHPNY---DPILLDADIAILKLLDKARI 572
K + V LG D + + + + +++HP+Y + DIA+L+L +
Sbjct: 295 KNQSVNVFLGHTAID---EMLKLGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIPL 351
Query: 573 STRVQPICLAASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEE 632
V P+CL + L S +++ G + G+ L+ + V C
Sbjct: 352 GPNVLPVCLPDNETLYRSGLLGYVSGFGMEM-------GWLTTELKYSRLPVAPREACNA 404
Query: 633 QHEDHGIPVSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWS 692
+ P +DNMFC + T +C ++G + V + A W G+VSW
Sbjct: 405 WLQKRQRPEVFSDNMFCVG-DETQRHSVCQGDSGSVYVV-WDNHAH---HWVATGIVSWG 459
Query: 693 YDKTCSHRLSTAFTKVLPFKDWIE 716
C +TKVL + DWI+
Sbjct: 460 IG--CGEGYD-FYTKVLSYVDWIK 480
>gi|148806900 epidermis-specific serine protease-like protein [Homo
sapiens]
Length = 328
Score = 82.8 bits (203), Expect = 1e-15
Identities = 71/262 (27%), Positives = 112/262 (42%), Gaps = 44/262 (16%)
Query: 461 RWPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADL 520
RWPWQ SLH F +C G+LV+ER ++ AAHC+ T
Sbjct: 38 RWPWQV------------SLHFDHNF-ICGGSLVSERLILTAAHCIQPTW-----TTFSY 79
Query: 521 KVVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPIC 580
V LG D R +S I++HP Y AD+A+LKL + ++ + PIC
Sbjct: 80 TVWLGSITVGDSRKR---VKYYVSKIVIHPKYQD--TTADVALLKLSSQVTFTSAILPIC 134
Query: 581 L-AASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGI 639
L + ++ L+ V GW + + + + L+ V ++D CE+ + GI
Sbjct: 135 LPSVTKQLAI---PPFCWVTGWGKVKESSDRDY-HSALQEAEVPIIDRQACEQLYNPIGI 190
Query: 640 ------PVSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSY 693
PV + ++ CA + D C ++GG + G W G+VSW
Sbjct: 191 FLPALEPV-IKEDKICAG-DTQNMKDSCKGDSGGPLSCHIDG------VWIQTGVVSWGL 242
Query: 694 DKTCSHRLSTAFTKVLPFKDWI 715
+ C L +T V+ ++ WI
Sbjct: 243 E--CGKSLPGVYTNVIYYQKWI 262
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 81.3 bits (199), Expect = 3e-15
Identities = 69/259 (26%), Positives = 107/259 (41%), Gaps = 34/259 (13%)
Query: 462 WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLK 521
WPWQ +++ G +C +L++ +V AAHC D
Sbjct: 626 WPWQVSLHALGQGH------------ICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWT 673
Query: 522 VVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICL 581
LG + R +Q ++ II HP ++ D DIA+L+L A S+ V+PICL
Sbjct: 674 AFLG-LHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICL 732
Query: 582 AASRDLSTSFQESH-ITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIP 640
D S F I V GW + G L+ G + V++ CE +P
Sbjct: 733 P---DASHVFPAGKAIWVTGW---GHTQYGGTGALILQKGEIRVINQTTCENL-----LP 781
Query: 641 VSVTDNMFCASWEPTAPSDICTAETGG-IAAVSFPGRASPEPRWHLMGLVSWSYDKTCSH 699
+T M C + + D C ++GG +++V GR G+VSW D
Sbjct: 782 QQITPRMMCVGF-LSGGVDSCQGDSGGPLSSVEADGRI------FQAGVVSWG-DGCAQR 833
Query: 700 RLSTAFTKVLPFKDWIERN 718
+T++ F+DWI+ N
Sbjct: 834 NKPGVYTRLPLFRDWIKEN 852
Score = 46.6 bits (109), Expect = 8e-05
Identities = 47/171 (27%), Positives = 66/171 (38%), Gaps = 32/171 (18%)
Query: 128 CGQVLRAPKGQILLE----SYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYM------- 176
CG LR +G YP N C W I +++RF +F Y+
Sbjct: 340 CGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRF-----KFFYLLEPGVPA 394
Query: 177 --CQYDYVEVRDGDNRDGQIIKRVCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 234
C DYVE+ ++ CG + S + + V FHSD S GF A Y
Sbjct: 395 GTCPKDYVEING---------EKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEY- 444
Query: 235 EITACSSSPCFHDGTCVLDKAGSYKCACLAGYTGQRCENLLEERNCSDPGG 285
++ SS PC TC + + C G+ C + +E NCS G
Sbjct: 445 -LSYDSSDPCPGQFTCRTGRCIRKELRC-DGWAD--CTDHSDELNCSCDAG 491
>gi|4505861 plasminogen activator, tissue isoform 1 preproprotein
[Homo sapiens]
Length = 562
Score = 80.9 bits (198), Expect = 4e-15
Identities = 80/268 (29%), Positives = 124/268 (46%), Gaps = 39/268 (14%)
Query: 463 PWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKV 522
PWQAAI+ + H S G FL C G L++ ++ AAHC + L V
Sbjct: 323 PWQAAIFAK----HRRS--PGERFL-CGGILISSCWILSAAHCFQE-----RFPPHHLTV 370
Query: 523 VLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDK----ARISTRVQP 578
+LG+ YR +E+ Q ++ I+H +D D DIA+L+L A+ S+ V+
Sbjct: 371 ILGRTYRVVPGEEE--QKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRT 428
Query: 579 ICLAASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHG 638
+CL + + E ++ G + + SP F ++ L+ V + S C QH
Sbjct: 429 VCLPPADLQLPDWTECELSGYGKH---EALSP-FYSERLKEAHVRLYPSSRCTSQHL--- 481
Query: 639 IPVSVTDNMFCA----SWEPTAP-SDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSY 693
+ +VTDNM CA S P A D C ++GG GR + L+G++SW
Sbjct: 482 LNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMT------LVGIISWGL 535
Query: 694 DKTCSHR-LSTAFTKVLPFKDWIERNMK 720
C + + +TKV + DWI NM+
Sbjct: 536 G--CGQKDVPGVYTKVTNYLDWIRDNMR 561
Score = 30.8 bits (68), Expect = 4.6
Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 236 ITACSSSPCFHDGTCVLDKAGS-YKCACLAGYTGQRCE 272
+ +CS CF+ GTC S + C C G+ G+ CE
Sbjct: 83 VKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 120
>gi|14702169 plasminogen activator, tissue isoform 3 preproprotein
[Homo sapiens]
Length = 516
Score = 80.9 bits (198), Expect = 4e-15
Identities = 80/268 (29%), Positives = 124/268 (46%), Gaps = 39/268 (14%)
Query: 463 PWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLKV 522
PWQAAI+ + H S G FL C G L++ ++ AAHC + L V
Sbjct: 277 PWQAAIFAK----HRRS--PGERFL-CGGILISSCWILSAAHCFQE-----RFPPHHLTV 324
Query: 523 VLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDK----ARISTRVQP 578
+LG+ YR +E+ Q ++ I+H +D D DIA+L+L A+ S+ V+
Sbjct: 325 ILGRTYRVVPGEEE--QKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRT 382
Query: 579 ICLAASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHG 638
+CL + + E ++ G + + SP F ++ L+ V + S C QH
Sbjct: 383 VCLPPADLQLPDWTECELSGYGKH---EALSP-FYSERLKEAHVRLYPSSRCTSQHL--- 435
Query: 639 IPVSVTDNMFCA----SWEPTAP-SDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSY 693
+ +VTDNM CA S P A D C ++GG GR + L+G++SW
Sbjct: 436 LNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMT------LVGIISWGL 489
Query: 694 DKTCSHR-LSTAFTKVLPFKDWIERNMK 720
C + + +TKV + DWI NM+
Sbjct: 490 G--CGQKDVPGVYTKVTNYLDWIRDNMR 515
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 16/76 (21%)
Query: 198 VCGNERPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYEEITACSSSPCFHDGTCVLDKAGS 257
+CG +P Q I H F G++++ G CS CF+ GTC S
Sbjct: 14 LCGAVFVSPSQEI----HARFRR-GARSYQG----------CSEPRCFNGGTCQQALYFS 58
Query: 258 -YKCACLAGYTGQRCE 272
+ C C G+ G+ CE
Sbjct: 59 DFVCQCPEGFAGKCCE 74
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 80.9 bits (198), Expect = 4e-15
Identities = 68/261 (26%), Positives = 114/261 (43%), Gaps = 40/261 (15%)
Query: 461 RWPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADL 520
RWPWQ ++ SG +C L+ ++ V+ AHC +
Sbjct: 812 RWPWQCSLQSEPSGH------------ICGCVLIAKKWVLTVAHCFEGRENAAV-----W 854
Query: 521 KVVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPIC 580
KVVLG + D +Q+ + IILHP Y ++D DI+I++L + + V+P+C
Sbjct: 855 KVVLG--INNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVC 912
Query: 581 LAASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIP 640
L +++ + GW + + + P FK L+ G V ++ C+ +
Sbjct: 913 LPNPEQWLE--PDTYCYITGWGHMGN-KMP-FK---LQEGEVRIISLEHCQSYFD----M 961
Query: 641 VSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRWHLMGLVSWSYDKTCSHR 700
++T M CA +E + D C ++GG PG RW L GL SW C +
Sbjct: 962 KTITTRMICAGYE-SGTVDSCMGDSGGPLVCEKPG-----GRWTLFGLTSWG--SVCFSK 1013
Query: 701 L--STAFTKVLPFKDWIERNM 719
+ ++ V F +WI+R +
Sbjct: 1014 VLGPGVYSNVSYFVEWIKRQI 1034
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 80.9 bits (198), Expect = 4e-15
Identities = 68/257 (26%), Positives = 114/257 (44%), Gaps = 45/257 (17%)
Query: 462 WPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERTVVVAAHCVTDLGKVTMIKTADLK 521
WPWQA++ + G H C +L++ R ++ AAHC + T +
Sbjct: 196 WPWQASM--QWKGRH-----------YCGASLISSRWLLSAAHCFAKKNN-SKDWTVNFG 241
Query: 522 VVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICL 581
+V+ K Y + ++ II H NY L DIA+++L ++ + ++ ICL
Sbjct: 242 IVVNKPY----------MTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICL 291
Query: 582 -AASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRSGVVSVVDSLLCEEQHEDHGIP 640
A LS + ++ V GW L G L+ + ++D+ +C + G
Sbjct: 292 PEAKMKLS---ENDNVVVTGWGTL---YMNGSFPVILQEDFLKIIDNKICNASYAYSGF- 344
Query: 641 VSVTDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPR--WHLMGLVSWSYDKTCS 698
VTD M CA + + +D C ++GG A P+ R WHL+G+VSW D
Sbjct: 345 --VTDTMLCAGF-MSGEADACQNDSGGPLAY-------PDSRNIWHLVGIVSWG-DGCGK 393
Query: 699 HRLSTAFTKVLPFKDWI 715
+T+V +++WI
Sbjct: 394 KNKPGVYTRVTSYRNWI 410
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,725,343
Number of Sequences: 37866
Number of extensions: 1612115
Number of successful extensions: 6040
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 210
Number of HSP's successfully gapped in prelim test: 245
Number of HSP's that attempted gapping in prelim test: 3375
Number of HSP's gapped (non-prelim): 2189
length of query: 720
length of database: 18,247,518
effective HSP length: 110
effective length of query: 610
effective length of database: 14,082,258
effective search space: 8590177380
effective search space used: 8590177380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.