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Search of human proteins with 50658069
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50658069 phosphodiesterase 4D interacting protein isoform 2
[Homo sapiens]
(969 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 1851 0.0
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 1851 0.0
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 1447 0.0
gi|169217489 PREDICTED: similar to phosphodiesterase 4D interact... 380 e-105
gi|50658077 phosphodiesterase 4D interacting protein isoform 4 [... 343 6e-94
gi|50658075 phosphodiesterase 4D interacting protein isoform 3 [... 325 1e-88
gi|88943074 PREDICTED: similar to Phosphodiesterase 4D interacti... 248 1e-65
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 226 1e-58
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 226 1e-58
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 139 1e-32
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 139 2e-32
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 137 6e-32
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 137 6e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 136 8e-32
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 136 8e-32
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 135 1e-31
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 135 2e-31
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 135 2e-31
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 135 2e-31
gi|156104908 myosin heavy chain 6 [Homo sapiens] 131 3e-30
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 131 3e-30
gi|16262452 cingulin [Homo sapiens] 130 6e-30
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 129 1e-29
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 9e-29
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 9e-29
gi|118498368 kinectin 1 isoform c [Homo sapiens] 126 1e-28
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 126 1e-28
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 125 1e-28
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 125 2e-28
gi|55770834 centromere protein F [Homo sapiens] 125 2e-28
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
[Homo sapiens]
Length = 969
Score = 1851 bits (4795), Expect = 0.0
Identities = 969/969 (100%), Positives = 969/969 (100%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR
Sbjct: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
Query: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK
Sbjct: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
Query: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ
Sbjct: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
Query: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH
Sbjct: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL
Sbjct: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
Query: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR
Sbjct: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
Query: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA
Sbjct: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
Query: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR
Sbjct: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Query: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL
Sbjct: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
Query: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT
Sbjct: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
Query: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ
Sbjct: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
Query: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI
Sbjct: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
Query: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ
Sbjct: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
Query: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK
Sbjct: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
Query: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD
Sbjct: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
Query: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE
Sbjct: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
Query: 961 AAHHSHQQL 969
AAHHSHQQL
Sbjct: 961 AAHHSHQQL 969
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1
[Homo sapiens]
Length = 2346
Score = 1851 bits (4795), Expect = 0.0
Identities = 969/969 (100%), Positives = 969/969 (100%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR
Sbjct: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
Query: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK
Sbjct: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
Query: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ
Sbjct: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
Query: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH
Sbjct: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL
Sbjct: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
Query: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR
Sbjct: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
Query: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA
Sbjct: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
Query: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR
Sbjct: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Query: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL
Sbjct: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
Query: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT
Sbjct: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
Query: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ
Sbjct: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
Query: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI
Sbjct: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
Query: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ
Sbjct: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
Query: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK
Sbjct: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
Query: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD
Sbjct: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
Query: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE
Sbjct: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
Query: 961 AAHHSHQQL 969
AAHHSHQQL
Sbjct: 961 AAHHSHQQL 969
Score = 43.9 bits (102), Expect = 7e-04
Identities = 51/203 (25%), Positives = 94/203 (46%), Gaps = 25/203 (12%)
Query: 756 SNAKEELELMAKKERESQMELSALQSMMA-VQEEELQVQAADMESLTRNIQIKEDLIKDL 814
S E + + + R + + LQ+ ++ V E Q + E+L + ++L K+L
Sbjct: 1891 SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL 1950
Query: 815 QMQLVDPEDI-PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRL 873
+ Q V+ + + + QEVL RE+ S++ + +R Q L++L+ +E+ +L
Sbjct: 1951 EHQKVERQQLLEDLREKQQEVLHFREERLSLQE-----NDSRLQHKLVLLQQQCEEKQQL 2005
Query: 874 NEALQAERQLYS-------------SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE- 919
E+LQ+E Q+Y SL H P SS+ L + + LR +LE+
Sbjct: 2006 FESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSD----LSHLVAEVRALRGQLEQS 2061
Query: 920 VLGRSLERLNRLETLAAIGGAAA 942
+ G + RL + L + G A+
Sbjct: 2062 IQGNNCLRLQLQQQLESGAGKAS 2084
Score = 43.1 bits (100), Expect = 0.001
Identities = 136/737 (18%), Positives = 265/737 (35%), Gaps = 104/737 (14%)
Query: 45 YKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYEL 104
Y ++ K ++ESL + + + L K + + A +++ Q+
Sbjct: 1428 YSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSY 1487
Query: 105 LENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPG----DQVK 160
L KI+ E C L ++ K K++ED+ D
Sbjct: 1488 LRQKIR--------------------EGRGICYL-ITRHAKDTVKSFEDLLRSNDIDYYL 1526
Query: 161 PDQYTEALAQRDKRIEELNQSLAAQ-----------ERLVEQLSREKQQLLHLLE----E 205
+ E LAQ + E L L+ + E L +LSRE Q+ ++E +
Sbjct: 1527 GQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAK 1586
Query: 206 PTSMEVQPMTEELLKQQKLNSHETTITQ---QSVSD----SHLAELQEKIQQTEATNKIL 258
+ + P + L + T+ ++ SD S +EK ++ I
Sbjct: 1587 LDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIH 1646
Query: 259 QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML 318
+ + + +SQ + +L + + +E Q G + L
Sbjct: 1647 HSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASL 1706
Query: 319 HQSQLGQLHSS----EGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQ 374
Q+ L SS T P + S L +Q E+Q LQ+ + + + A
Sbjct: 1707 PQAPLPSAPSSFLPFSPTGPLLLGCCETPVVS-LAEAQQELQMLQKQLGESASTVPPAST 1765
Query: 375 CVQFVEAAAHESEQQKEASWKHNQ-----ELRKALQQLQEELQNKSQQLRAWEAEKYNEI 429
+S ++ H+ EL + L+ K +R + ++
Sbjct: 1766 ATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDL 1825
Query: 430 RTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA---- 485
+ ++ LN + + L + E+ R ++++ N+ L E+L R+ A
Sbjct: 1826 -SSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRG 1884
Query: 486 ----------VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ 535
++ + +E E+ + QL RE + E LR+ L S+ + +Q
Sbjct: 1885 STSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQ 1944
Query: 536 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQTSLHDRNKEV 594
+E L + +E +QL L+ L+E K+QE + ++ + SL + + +
Sbjct: 1945 ELEKELEHQKVERQQL------LEDLRE----------KQQEVLHFREERLSLQENDSRL 1988
Query: 595 EDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEI---QGLLQS 651
+ L Q E ++L + LQ + ++ + L + K + + ++ L
Sbjct: 1989 QHKLVLL-----QQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSD 2043
Query: 652 VSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK 711
+S E +A +L Q++ N L+Q L S +P S Q
Sbjct: 2044 LSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQN-------FPA 2096
Query: 712 QTDQGSMQIPSRDDSTS 728
TD G+ Q+ +D + S
Sbjct: 2097 STDPGNKQLLLQDSAVS 2113
Score = 33.9 bits (76), Expect = 0.76
Identities = 42/155 (27%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 731 AKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMEL-------------- 776
++E S+ + L + LEKEL + K E + + + RE Q E+
Sbjct: 1926 SQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND 1985
Query: 777 SALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI----KDLQMQLVDP-EDIPAMERLT 831
S LQ + + +++ + + ESL +QI E L K L+ +D IP L+
Sbjct: 1986 SRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLS 2045
Query: 832 QEVLLLREKVASVESQGQEISGNR--RQQLLLMLE 864
V +R +E Q I GN R QL LE
Sbjct: 2046 HLVAEVRALRGQLE---QSIQGNNCLRLQLQQQLE 2077
Score = 32.7 bits (73), Expect = 1.7
Identities = 66/323 (20%), Positives = 128/323 (39%), Gaps = 43/323 (13%)
Query: 257 ILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER---ETEELY-QVIEGQNDTMA 312
+L+E L E+ + +ES D + L+ L S R T Y Q +E
Sbjct: 1843 LLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
Query: 313 KLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA 372
+ R + ++ Q S + Q+ L+ AL S+ +Q+L++ + E Q +
Sbjct: 1903 ENRVLREDNRRLQAQLSHVSREHSQETE--SLREALLSSRSHLQELEK---ELEHQKVER 1957
Query: 373 KQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ 432
+Q + E ++K+ H +E R +LQ+ LQ+K L+ EK +
Sbjct: 1958 QQLL--------EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESL 2009
Query: 433 EQNIQHLN------------------HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLL 474
+ +Q H + L E+ R +++++ N L
Sbjct: 2010 QSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLR 2069
Query: 475 EKLRQRIHD---KAVALERAIDEKFSALEE---KEKELRQLRLAVRERDHDLERLRDVLS 528
+L+Q++ KA +I++ F A + K+ L+ ++ RD + V
Sbjct: 2070 LQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFP 2129
Query: 529 SNEATMQSMES--LLRAKGLEVE 549
S+ ++ E+ + RA GL ++
Sbjct: 2130 SSASSTPGSETPIINRANGLGLD 2152
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [Homo
sapiens]
Length = 1132
Score = 1447 bits (3747), Expect = 0.0
Identities = 761/768 (99%), Positives = 763/768 (99%)
Query: 202 LLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 261
L E+ + VQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK
Sbjct: 365 LCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 424
Query: 262 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 321
LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS
Sbjct: 425 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 484
Query: 322 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 381
QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA
Sbjct: 485 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 544
Query: 382 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH
Sbjct: 545 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 604
Query: 442 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE
Sbjct: 605 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 664
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL
Sbjct: 665 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 724
Query: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ
Sbjct: 725 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 784
Query: 622 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 681
RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR
Sbjct: 785 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 844
Query: 682 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 741
QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST
Sbjct: 845 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 904
Query: 742 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT
Sbjct: 905 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 964
Query: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL
Sbjct: 965 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 1024
Query: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 921
MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL
Sbjct: 1025 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
Query: 922 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 969
GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL
Sbjct: 1085 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 1132
Score = 78.6 bits (192), Expect = 3e-14
Identities = 132/597 (22%), Positives = 247/597 (41%), Gaps = 109/597 (18%)
Query: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQ 90
E + E +E +K N EL+ ++ L+ ELQ+K Q L + W EAE +
Sbjct: 543 EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNE 591
Query: 91 FEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKL------ 144
++Q +H+ L +K QLLQE L + L E N L EKL
Sbjct: 592 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLRQRIHD 646
Query: 145 ------KGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL---------- 188
+ + + + + + + Q A+ +RD +E L L++ E
Sbjct: 647 KAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRA 706
Query: 189 ----VEQLSREKQQLLHLLEEPTS--MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
VEQLS Q L L EE + Q E +++Q + + H+ + +S + L
Sbjct: 707 KGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC 766
Query: 243 EL--------QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE 294
+L +E Q+ + ++LQ+ L++ + ++ + + IQ L +++ +RE
Sbjct: 767 KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV-------LEHEMEIQGLLQSVSTRE 819
Query: 295 RET----EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
+E+ E+L Q + +N + LR+ LG S +P Q A + L
Sbjct: 820 QESQAAAEKLVQALMERNSELQALRQ-----YLGGRDSLMSQAPISNQQAEVTPTGCL-G 873
Query: 351 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ----QKEASWKHNQELRKALQQ 406
Q + +Q R L AK+ V + + + +KE S + +E + + +
Sbjct: 874 KQTDQGSMQIPSRDDSTSLT-AKEDVSIPRSTLGDLDTVAGLEKELS--NAKEELELMAK 930
Query: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
+ E Q + L++ A + E++ Q +++ L ++ KE L+++ + +Q D D
Sbjct: 931 KERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQ--MQLVDPEDIP 988
Query: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKEL-----RQLRLAVRERDHDLE 521
+E+L Q + + EK +++E + +E+ +QL L + +
Sbjct: 989 ------AMERLTQEV--------LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 1034
Query: 522 RLRDVLSSNEATMQSM-------ESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 571
RL + L + S+ ES R + L+VE + Q L+ +E R
Sbjct: 1035 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE-----LEGAQVLRSRLEEVLGR 1086
>gi|169217489 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 211
Score = 380 bits (975), Expect = e-105
Identities = 195/198 (98%), Positives = 197/198 (99%)
Query: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 457
+ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL
Sbjct: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
Query: 458 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 517
QYRDNSDKTLEANEMLLEKLRQRI DKAVALERAIDEKFSALEEKEKELRQLRLAVRERD
Sbjct: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
Query: 518 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 577
HDLERLRDVLSSNEATMQ+MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE
Sbjct: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
Query: 578 SIIQQLQTSLHDRNKEVE 595
SIIQQLQTSLHDRNKEVE
Sbjct: 182 SIIQQLQTSLHDRNKEVE 199
Score = 48.5 bits (114), Expect = 3e-05
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----QKQDGTIQNLKETLKSRERE 296
+ EL++ +QQ LQE+L S +L+ + + Q+ IQ+L +L +E+
Sbjct: 1 MEELRKALQQ-------LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
Query: 297 TEELYQVIE--GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 354
+E ++++ +D + EML L +L + A+ + SAL + E
Sbjct: 54 LQEFRELLQYRDNSDKTLEANEML----LEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
Query: 355 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 414
+++L+ VR+++ L + + EA E A ++L Q LQ +
Sbjct: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
Query: 415 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
+ W+ E+ + I+ + ++ N + + QL R+L+Q
Sbjct: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL--TLRQLVQ 211
Score = 45.8 bits (107), Expect = 2e-04
Identities = 61/254 (24%), Positives = 103/254 (40%), Gaps = 52/254 (20%)
Query: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKI 109
EL+ ++ L+ ELQ+K Q L + W EAE + ++Q +H+ L +K
Sbjct: 3 ELRKALQQLQEELQNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSHKE 51
Query: 110 QLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALA 169
QLLQE L + L E N L EKL+ + +
Sbjct: 52 QLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR----------------QRIRDKAV 90
Query: 170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHET 229
++ I+E +L +E+ + QL ++ H LE + L+S+E
Sbjct: 91 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER--------------LRDVLSSNEA 136
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
T+ +S L +++Q T + LQ EM + Q ++Q+ IQ L+ +
Sbjct: 137 TM---QTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTS 190
Query: 290 LKSRERETEELYQV 303
L R +E E Q+
Sbjct: 191 LHDRNKEVEARLQL 204
>gi|50658077 phosphodiesterase 4D interacting protein isoform 4
[Homo sapiens]
Length = 173
Score = 343 bits (879), Expect = 6e-94
Identities = 173/173 (100%), Positives = 173/173 (100%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR
Sbjct: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
Query: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK
Sbjct: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
Query: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK
Sbjct: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/115 (30%), Positives = 52/115 (45%), Gaps = 16/115 (13%)
Query: 380 EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNE 428
E + E +E +K N EL+ ++ L+ ELQ+K Q L + W EAE +
Sbjct: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQ 90
Query: 429 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR 478
++Q +H+ L +K QLLQE L + L E N L EKL+
Sbjct: 91 FEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 145
>gi|50658075 phosphodiesterase 4D interacting protein isoform 3
[Homo sapiens]
Length = 310
Score = 325 bits (833), Expect = 1e-88
Identities = 164/168 (97%), Positives = 165/168 (98%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
R +HLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK
Sbjct: 143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 202
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR
Sbjct: 203 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 262
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK
Sbjct: 263 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 310
Score = 43.9 bits (102), Expect = 7e-04
Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 24/143 (16%)
Query: 360 RVVRQKERQLADAKQ-------CVQFVEAAAHES-EQQKEASWKHNQELRKALQQLQEEL 411
+ +R E+ L D K+ + F+E + E +E +K N EL+ ++ L+ EL
Sbjct: 140 QALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL 199
Query: 412 QNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
Q+K Q L + W EAE + ++Q +H+ L +K QLLQE L +
Sbjct: 200 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 259
Query: 461 DNSDKTL-----EANEMLLEKLR 478
L E N L EKL+
Sbjct: 260 AARMAALVEAEKECNLELSEKLK 282
>gi|88943074 PREDICTED: similar to Phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 134
Score = 248 bits (634), Expect = 1e-65
Identities = 125/127 (98%), Positives = 126/127 (99%)
Query: 47 RNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE 106
+N ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE
Sbjct: 8 QNTELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE 67
Query: 107 NKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE 166
NKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE
Sbjct: 68 NKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE 127
Query: 167 ALAQRDK 173
ALAQRDK
Sbjct: 128 ALAQRDK 134
Score = 37.7 bits (86), Expect = 0.052
Identities = 31/98 (31%), Positives = 45/98 (45%), Gaps = 16/98 (16%)
Query: 397 NQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSH 445
N EL+ ++ L+ ELQ+K Q L + W EAE + ++Q +H+ L +
Sbjct: 9 NTELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLEN 68
Query: 446 KEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR 478
K QLLQE L + L E N L EKL+
Sbjct: 69 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 106
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 226 bits (575), Expect = 1e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
Query: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
Query: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
Query: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
Query: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
Query: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
Score = 72.4 bits (176), Expect = 2e-12
Identities = 143/676 (21%), Positives = 283/676 (41%), Gaps = 119/676 (17%)
Query: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
Query: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
Query: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
Query: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
Query: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
Query: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
Query: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
E I+ L +S + ++ Q EK ++ ++++N L A + L+++ S+QQ
Sbjct: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDLELRSEGLITE-KCSSQQP 533
Query: 702 EVTPTGCLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLE 752
+ T K+ Q S +Q+ +D T L + +E SI + +L+ + L
Sbjct: 534 PGSKT-IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALR 591
Query: 753 KEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAADME 798
K+L +E++ + ++E ES S S +++ EE QV+ E
Sbjct: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE 651
Query: 799 SLTRNIQIKEDLIKDL 814
L + + L+K+L
Sbjct: 652 ELKKKVSDLIQLVKEL 667
Score = 47.8 bits (112), Expect = 5e-05
Identities = 82/412 (19%), Positives = 161/412 (39%), Gaps = 63/412 (15%)
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
Query: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
Query: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
Query: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
Query: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
Query: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
L + QK +R ES +K S +H Q ++++
Sbjct: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
Query: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
E LQ + + + E+R Q + + + ++QLL + +LLQ
Sbjct: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
Score = 40.4 bits (93), Expect = 0.008
Identities = 83/397 (20%), Positives = 166/397 (41%), Gaps = 56/397 (14%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
RTL + L + K N L+ ++ ER ++ I+ EL + S L+ +
Sbjct: 1403 RTLRKRLEESIKTNEKLRKQL----ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK---IQLLQEESRLAKNE 122
Q L+ A L + ++Q+E + + E L K ++ LQ E K E
Sbjct: 1459 NQALN--------------AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
R+ ++ N +L ++++ + V ++VK Q + L+Q DK ++ L L
Sbjct: 1505 NERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-EEVKLRQ--QLLSQNDKLLQSLRVEL 1561
Query: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
A E+L E+ R + + +E S ++ ++ + + + ET + +DS
Sbjct: 1562 KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK---SVSETPPLSGNDTDSLSC 1618
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN----LKETLKSRERETE 298
+ T ++++ + L A ++ + G I++ LK+ + + E
Sbjct: 1619 DSGSSATSTPCVSRLV------TGHHL-WASKNGRHVLGLIEDYEALLKQISQGQRLLAE 1671
Query: 299 ELYQVIEGQNDTMAKL-REMLHQSQLGQLHSSEGTS-----PAQQQVALL-------DLQ 345
Q E + T +L + H + L + SS T+ A +++ LL D Q
Sbjct: 1672 MDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQ 1731
Query: 346 SALFCSQL-----EIQKLQRVVRQKERQLADAKQCVQ 377
L C Q+ E+ KL + + ++E++L + + +Q
Sbjct: 1732 CPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQ 1768
Score = 36.2 bits (82), Expect = 0.15
Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%)
Query: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
Query: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ E+ + + ++ E E S + QDLL
Sbjct: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
Query: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
Query: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
Query: 812 KDLQMQLVDPEDIPAMERLTQEVLLLRE 839
+ L+++L A E+L +E LR+
Sbjct: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576
Score = 34.7 bits (78), Expect = 0.44
Identities = 50/249 (20%), Positives = 102/249 (40%), Gaps = 38/249 (15%)
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
+D+KQ + V +NS ++ L +E + + + E ++ +L ++ R
Sbjct: 1372 RDQKQDNETEKTSVM-VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF 1430
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
++ + E + L+ ++ + K + + +K RDK+ E
Sbjct: 1431 VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK--------GSRDKQKEN----- 1477
Query: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
++L E LSR+ L HL E S++ EE + QK S + QQ + + +
Sbjct: 1478 ---DKLRESLSRKTVSLEHLQREYASVK-----EENERLQKEGSEKERHNQQLIQEVRCS 1529
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 302
++L+ + E+K Q+ + D +Q+L+ LK+ E+ EE +
Sbjct: 1530 ----------------GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573
Query: 303 VIEGQNDTM 311
+ +G M
Sbjct: 1574 LRDGDKYPM 1582
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 226 bits (575), Expect = 1e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
Query: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
Query: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
Query: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
Query: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
Query: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
Score = 72.4 bits (176), Expect = 2e-12
Identities = 143/676 (21%), Positives = 283/676 (41%), Gaps = 119/676 (17%)
Query: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
Query: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
Query: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
Query: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
Query: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
Query: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
Query: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
E I+ L +S + ++ Q EK ++ ++++N L A + L+++ S+QQ
Sbjct: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDLELRSEGLITE-KCSSQQP 533
Query: 702 EVTPTGCLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLE 752
+ T K+ Q S +Q+ +D T L + +E SI + +L+ + L
Sbjct: 534 PGSKT-IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALR 591
Query: 753 KEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAADME 798
K+L +E++ + ++E ES S S +++ EE QV+ E
Sbjct: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE 651
Query: 799 SLTRNIQIKEDLIKDL 814
L + + L+K+L
Sbjct: 652 ELKKKVSDLIQLVKEL 667
Score = 50.1 bits (118), Expect = 1e-05
Identities = 104/504 (20%), Positives = 198/504 (39%), Gaps = 79/504 (15%)
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
Query: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
Query: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
Query: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
Query: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
Query: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
L + QK +R ES +K S +H Q ++++
Sbjct: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
Query: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
E LQ + + + E+R Q + + + ++QLL + +LLQ +
Sbjct: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ---SLRVE 1560
Query: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 526
L+A E L E+ R+ L A E + ++ ++L L + ++ LER +
Sbjct: 1561 LKAYEKLDEEHRR--------LREASGEGWKG-QDPFRDLHSLLMEIQALRLQLERSIET 1611
Query: 527 LSSNEATMQSMESLLRAKGLEVEQ 550
S T+QS A+G E Q
Sbjct: 1612 SS----TLQSRLKEQLARGAEKAQ 1631
Score = 40.4 bits (93), Expect = 0.008
Identities = 112/521 (21%), Positives = 206/521 (39%), Gaps = 94/521 (18%)
Query: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
Query: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ E+ + + ++ E E S + QDLL
Sbjct: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
Query: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
Query: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
Query: 812 KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 871
+ L+++L A E+L +E LRE AS E + LL+ ++ L R
Sbjct: 1555 QSLRVEL------KAYEKLDEEHRRLRE--ASGEGWKGQDPFRDLHSLLMEIQAL---RL 1603
Query: 872 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 912
+L +++ L S L + A ++ L + ++ +
Sbjct: 1604 QLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSI 1644
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 139 bits (350), Expect = 1e-32
Identities = 217/980 (22%), Positives = 426/980 (43%), Gaps = 99/980 (10%)
Query: 4 GYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASR-EDIYKRNIELKVEVESLKREL 62
G R S L++L+KEN LK +++ +E M++ + + E++ + N+ L E +++
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDME--MERDMDRKKIEELMEENMTL----EMAQKQS 422
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ---EESRLA 119
D+ HL + + +EA + E + T LE + Q L EE R
Sbjct: 423 MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
Query: 120 KNEAARMAA-LVEAEKECNLELSEKLK----GVTKNWEDVPGDQVKPDQYTEALAQRDKR 174
+ A+ +++ EKE N LS+K++ + + + + Q + AQ +K
Sbjct: 483 VDSVEGNASKILKMEKE-NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 175 IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
IE L ++ Q +++EQ + Q + L + + + + +++ K+ K+ T
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 235 SVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLK 291
+S + Q K + K E+ E+ EL ++ ++ I NLK E ++
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEK--GERAEELENELHHLEKENELLQKKITNLKITCEKIE 659
Query: 292 SRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS 351
+ E+E EL + T+ + + Q + + E + ++ + L +L C+
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLE---KENSQLDEENLELRRNVESLKCA 716
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK----HNQELRKALQQL 407
+++ +LQ ++ E + K+ ++ ++A+ ++E+ E S++ NQ L+K L+
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL-EVSYQGLDIENQRLQKTLENS 775
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL 467
+++Q +L+ E E +T ++N++ L S EQL +E + L Q +K
Sbjct: 776 NKKIQQLESELQDLEMEN----QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 468 EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQ---------LRLAVRERDH 518
+ E ++LRQ+ K LE + K LE++ K L + +RL E+++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEEN-NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 519 ------------DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEME 566
L LR+ L S + Q M + L E+E++ + L L +E
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL--LHDEQS 948
Query: 567 TKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERM 626
T SR++ + + L+ SL + +++ L A L + ++L Q L+ ++
Sbjct: 949 TDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL-----EESTNYNQQLRQELKTVKKN 1003
Query: 627 LQDLLSDRNKQ-VLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME---RNSELQALRQ 682
+ L ++++ +++ I G QE+ K+ L+E N+ LQA +Q
Sbjct: 1004 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1063
Query: 683 YLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 742
L + + + +N QA++ L Q S+Q ++T T + + STL
Sbjct: 1064 ALKTQLKQL-ETQNNNLQAQI-----LALQRQTVSLQ---EQNTTLQTQNAKLQVENSTL 1114
Query: 743 GDLDTV-----AGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQV----Q 793
T A L + S+ + E E + KERE +L +L + E+L++ Q
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVI-KERE---DLKSLYDSLIKDHEKLELLHERQ 1170
Query: 794 AADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISG 853
A++ ESL + K+L+++ D ED + L EK+ VE + +
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 854 NRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD-RTLQVELEGAQV 912
+ + + L E RLN YS L+K E + D + L+ L +++
Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHT-------YSQLLK---ETEVLQTDHKNLKSLLNNSKL 1280
Query: 913 LRSRLEEVLGRSLERLNRLE 932
++RLE + E+ +L+
Sbjct: 1281 EQTRLEAEFSKLKEQYQQLD 1300
Score = 103 bits (257), Expect = 8e-22
Identities = 211/1002 (21%), Positives = 404/1002 (40%), Gaps = 159/1002 (15%)
Query: 35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHL---------DKTWADVENLNSQNEA 85
QK E E I + + K V + +E+ ++++ D + D+E L
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 86 ELRRQFEERQQETEHVYELLENK--IQLLQEESRLAKNEAARMA-ALVEAEKECNLELSE 142
L+R +ER + +E + EL E + + L S A++ E+ + ++EL++
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 143 ---KLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS------ 193
K++ + + E+ + Q E + KR+++ N +L + R
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 194 REKQQLLHLLEEPTSMEVQPM---------TEELLKQQKLNSHETTITQQSVSDSHLAEL 244
REK + LE S + + EEL + ++ T+ + + +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR-- 373
Query: 245 QEKIQQTEATNKILQEKLNEMSYE-----------------LKCAQESSQKQD----GTI 283
+K+ + E N L+ KL++M E L+ AQ+ S + +
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 284 QNLKETLKSRERETEEL-YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 342
+ + T + E + L ++V E + + KL EM +QS + T + + A
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTTVDSVEGNA-- 490
Query: 343 DLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ------------------FVEAAAH 384
S + + E Q+L + V E ++ KQ +Q +E
Sbjct: 491 ---SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 385 ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
SE+Q + + N+ L + + L++ Q S + R + EK N+I ++I+ + LS
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKI--LHESIKETSSKLS 604
Query: 445 HKE-QLLQEFRELLQYRDNSDKTLEANEML--LEKLRQRIHDKAVALERAIDEKFSALEE 501
E + Q +EL Y++ ++ E L LEK + + K L + EK ALE+
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQ 663
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQ--LSTTCQNLQ 559
+ EL + +++ + L L S ++ S L + LE+ + S C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENLELRRNVESLKCASMK 719
Query: 560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR 619
+ ++E KE ES +QL+ L L K ++E E Q
Sbjct: 720 MAQLQLE------NKELESEKEQLKKGLE-------------LLKASFKKTERLEVSYQG 760
Query: 620 LQRKERMLQDLLSDRNKQVLEHEMEIQGL---LQSVSTREQESQAAAEKLVQALMERNSE 676
L + + LQ L + NK++ + E E+Q L Q++ +E + ++++L Q E S
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 677 LQALRQYLGGRDSLMSQAPISNQQAEVTPT---------GCLGKQTDQGSMQIPSRDDS- 726
Q Q + L + QQAE+ T G L K+ S +I +S
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC 880
Query: 727 --TSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELS------- 777
KE+ + + D+ T+ L ++L + K + + M + EL
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Query: 778 -ALQSMMAVQEEELQVQAADMES-LTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVL 835
L + + ++ + +ES L ++++IKE+ I L+ +L E ++L QE+
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL--EESTNYNQQLRQELK 998
Query: 836 LLREKVASVESQGQE---------ISGNRRQ---------QLLLMLEGLVDERSRLNEAL 877
+++ +++ + E ISG + + LL ++ + E R N L
Sbjct: 999 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
Query: 878 QAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 919
QAE+Q + +K + ++ LQ ++ Q L+E
Sbjct: 1059 QAEKQALKTQLK-----QLETQNNNLQAQILALQRQTVSLQE 1095
Score = 82.4 bits (202), Expect = 2e-15
Identities = 129/657 (19%), Positives = 281/657 (42%), Gaps = 57/657 (8%)
Query: 5 YRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVE---VESLKRE 61
Y+ L L+K + +I LE +Q E + + K ELK+ +E L++E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQD-LEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 62 LQDKKQHLDKTWADVENLNSQNEAELRRQFEERQ---QETEHVYELLENKIQLLQEESRL 118
+ +Q + D + L +N+ LR+Q E + +E LE + + L +E +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENK-RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 119 AKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEEL 178
K R+ L + KE + +K + ED+ +++K Q L + +E++
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 179 NQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSD 238
+ +ERL+ LLE ++ E +K++K+ + E + + + +
Sbjct: 936 GLN---KERLLHDEQSTDDSRYKLLESKLESTLKKSLE--IKEEKIAALEARLEESTNYN 990
Query: 239 SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETE 298
L + + +++ K Q++ + + E ++ + + + +E LK ++R E
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 299 ELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ------QQVALLDLQSALFCSQ 352
+E N T+ ++ L ++QL QL + AQ Q V+L + + L
Sbjct: 1051 -----VERNNATLQAEKQAL-KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
++Q + + L + + +++ E + E+ K ++L+ L ++
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSL---ENENESVIKEREDLKSLYDSLIKD-H 1160
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQ--HLNHSLSHKEQLLQEFRELLQYR---DNSDKTL 467
K + L +A +Y + ++ ++ H N + H++ L + +LL+ + ++ +K L
Sbjct: 1161 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD-LEDRYNQLLKQKGQLEDLEKML 1219
Query: 468 --EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRD 525
E +MLLE + H+ A + + + L +L + V + DH + L+
Sbjct: 1220 KVEQEKMLLEN---KNHETVAAEYKKLCGENDRLNHTYSQLLK-ETEVLQTDH--KNLKS 1273
Query: 526 VLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQT 585
+L++++ +E+ + +QL T L E + ++E ++ Q+QT
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1333
Query: 586 ------SLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNK 636
+L ++N E +DL Q + ++L L+R++ L++ + D+ K
Sbjct: 1334 LMLQNRTLLEQNMESKDL-------FHVEQRQYIDKL-NELRRQKEKLEEKIMDQYK 1382
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 139 bits (349), Expect = 2e-32
Identities = 221/1017 (21%), Positives = 439/1017 (43%), Gaps = 104/1017 (10%)
Query: 15 LKKENFSLKLRIYFLEERMQQKYEAS-------REDIYKRNIELKVEVESLKRELQDKKQ 67
L++E S KL+ +++Q +Y +S R ++ K E+ V V+ L++ +
Sbjct: 242 LERERESEKLKDEC--KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299
Query: 68 HLDKTWADVENL--NSQNEAELRRQFEERQQETEHVYELLENK-IQLLQEESRLAKNEAA 124
K ENL Q+ +L + E +++ L K + Q +SRL+ +E +
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 125 RMAALVEAEK--ECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIE-ELNQS 181
VE + E +L E+L V ++ + + + Q E Q +++ E+NQ
Sbjct: 360 LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 182 LA-----------AQERLVEQLSREKQQLLHLLEEPTSMEVQ-PMTEELLKQQKLNSHET 229
+ A RL EQ ++L+ ++ ++++ EE LK++ NS E
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
H E Q Q T A + Q L ++ ++ + Q + +Q KE
Sbjct: 480 QHQLDKTKQQH-QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Query: 290 LKSRERETEELY---QVIEGQNDTMAKLREMLH--QSQLGQL-----HSSEGTSPAQQQV 339
+ E+E E+LY Q EG+ + +L+E H Q Q+ QL + SE AQ+ +
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL 598
Query: 340 --ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ----FVEAAAHESEQQKEAS 393
+ + ++ L +Q + L+ V + QL ++K+ V ++A + A
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 394 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ-EQNIQHLNHSLSHKEQL--- 449
+L+ L Q LQ+K Q+L N+I TQ +Q L H QL
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLDQVTAKLQDKQEHCSQLESH 710
Query: 450 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQL 509
L+E++E +Y KT E LE +++ ++ ++ + ++ L+++ + L
Sbjct: 711 LKEYKE--KYLSLEQKTEE-----LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Query: 510 RLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKF 569
L E LE ++++SS +Q L + ++L+ + Q LK++ ET
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALES---IKQKLTKQEEEKQILKQDFETLS 820
Query: 570 SRWQKEQESIIQQLQTSLHDRNK---EVEDLSATL------LCKLGPGQSEIAEELCQRL 620
+ + E + ++QT++ + K E E L L L K+ E +
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 621 QRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQAL 680
Q+ + + DL ++ + L+H++++Q +++ ++E + + EK +A + EL ++
Sbjct: 881 QKGKAAILDL--EKTCKELKHQLQVQ--MENTLKEQKELKKSLEKEKEASHQLKLELNSM 936
Query: 681 RQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRS 740
++ L + + Q QQ + L + ++Q QI + + + +
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGN-INELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995
Query: 741 TLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESL 800
L A +EL+ KE++ ++ +SQ LQS +E EL D++S+
Sbjct: 996 LQQQLTQAA---QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 801 TRNIQI-KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQE---ISGNRR 856
+ + +EDLI + + Q+ + + ++ L L + A E Q QE + +
Sbjct: 1053 EEKLSLAQEDLISN-RNQIGNQNKL--IQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 857 QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQV-ELEGAQ--VL 913
++ L + LV+E+S+L E + + + + K + +S + + ++ L+ A+ ++
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 914 RSRLE-----EVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHS 965
+ +LE + L ++E+ R + + + E+ EF IE+EA HS
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILK---DQVKKEEEELKKEF---IEKEAKLHS 1220
Score = 103 bits (258), Expect = 6e-22
Identities = 178/903 (19%), Positives = 370/903 (40%), Gaps = 137/903 (15%)
Query: 152 EDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLE------- 204
+D+ + Y+E L + ++ + L Q A + LV S E Q L LE
Sbjct: 93 QDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENF 152
Query: 205 ----------------------------------EPTSMEVQPMTEELLKQQKLNSHETT 230
E +V +TEEL K+ + T
Sbjct: 153 NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKT 212
Query: 231 ITQQSVSDSHLAELQEKIQQTEA--TNKILQEKLNEMSYELKCAQESSQ--KQDGTIQNL 286
Q +A L++++ Q + N L+ + + +C + SQ + TI L
Sbjct: 213 ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL 272
Query: 287 KETLKSRERE----TEELYQVIEGQNDTMAK--------LREMLHQSQLGQLHSSEGTSP 334
+ L +E +EL ++ N+ K L++ ++L + H+ E S
Sbjct: 273 RSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK 332
Query: 335 AQQQVAL----LD---LQSALFCSQLEIQKLQRVVRQK-------ERQLADAKQCVQFVE 380
Q L LD LQS L S+ + ++ + +K + +L++ + Q ++
Sbjct: 333 KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 381 AAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLN 440
A + +QQ+E +H +L+ + QL +L +QL E + ++ Q Q +
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL----GEAHGRLKEQR---QLSS 445
Query: 441 HSLSHKEQLLQEFRELLQYRDN--SDKTLEANEM--LLEKLRQRIHDKAVALERAIDEKF 496
L KEQ + + + L + +K + E+ L+K +Q+ H + AL+++ K
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-HQEQQALQQSTTAK- 503
Query: 497 SALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSME-------SLLRAKGLEVE 549
L E + +L Q+ + ++D ++ L +L ++ + +E + ++A E
Sbjct: 504 --LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 550 QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKE-------VEDLSATLL 602
L+ + L+E++ T+ + K Q +Q Q +LHD+ +E +D +L
Sbjct: 562 VLNQLQEKNHTLQEQV-TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620
Query: 603 CKLGPGQSEIAE--ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
+ S++ E E +L + + +LL ++Q L + Q+ Q
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAP---ISNQQAEVTPTGCLGKQTDQGS 717
K+ L + ++LQ +++ +S + + +S +Q G + K+ + S
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI-KKLEADS 739
Query: 718 MQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVA-GLEKELSNAKEELELMAKKERESQMEL 776
+++ + + A +D+ R DL+ A L K+L KE + ++ L
Sbjct: 740 LEVKASKEQ----ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 777 SALQSMMAVQEEELQVQAADMESLTRNIQIK-EDLIKDLQMQLVDPEDIP-AMERLTQEV 834
+++ + QEEE Q+ D E+L++ +I+ E+L +Q + + + + E L E+
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 835 LLLREKVASV-----------ESQGQ----------EISGNRRQQLLLMLEGLVDERSRL 873
+++K++ V E + Q + + QL + +E + E+ L
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 874 NEALQAERQLYSSL-VKFHAHPES-SERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRL 931
++L+ E++ L ++ ++ E + TL+ + Q L+ + E+ S ++ ++
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 932 ETL 934
E L
Sbjct: 976 EAL 978
Score = 60.1 bits (144), Expect = 1e-08
Identities = 91/436 (20%), Positives = 184/436 (42%), Gaps = 65/436 (14%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQ----QKYEASREDIYKRNIELKVEVESLKRELQ 63
L ++N+LK+ + K +I L+ ++ QK E + L+ ++ +EL
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK--------LQQQLTQAAQELA 1008
Query: 64 DKKQHLDKTWADVENLNSQNEAELRRQFEERQQE---TEHVYELLENKIQLLQEESRLAK 120
+K+ + + E + + +L+ F R+ E T + +E K+ L QE+ +
Sbjct: 1009 AEKEKISVLQNNYEK-SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 121 NEAARMAALVEAEKECNLELSE-------KLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
N+ L++ K L + +L+ K +D+ Q + + L
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI---QKEKSLKEKELVNEKS 1124
Query: 174 RIEELNQSLAAQERLVEQLSRE-KQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
++ E+ + QE+ + +L+ E K L ++E T+++ ++LL QQKL
Sbjct: 1125 KLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD---AKQLLIQQKLEL------ 1175
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET--- 289
Q +DS L+ ++Q + +IL++++ + ELK +E +K+ +KE
Sbjct: 1176 -QGKADS----LKAAVEQEKRNQQILKDQVKKEEEELK--KEFIEKEAKLHSEIKEKEVG 1228
Query: 290 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD------ 343
+K E +L I N+ + +++ SQ + T + ++A+L+
Sbjct: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN 1288
Query: 344 ------LQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397
L + EI+KLQ V + +R+L + VQ + + + KH
Sbjct: 1289 QDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL------GRENQSLQIKHT 1342
Query: 398 QELRKALQQLQEELQN 413
Q L + + E+QN
Sbjct: 1343 QALNRKWAE-DNEVQN 1357
Score = 45.1 bits (105), Expect = 3e-04
Identities = 103/484 (21%), Positives = 199/484 (41%), Gaps = 103/484 (21%)
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ--------------- 573
SN A + +LLR EV+ L + + +W EE++ + ++Q
Sbjct: 76 SNLALKRDDVTLLRQ---EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132
Query: 574 --KEQESIIQQLQTSLHD--RNKEVEDL----SATLLCKLGPGQSEIAEE---------- 615
E +S+ QQL+ + + K+++DL +A L ++ +S+ EE
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 616 ---LCQRLQRKERMLQDLLSD-------RNKQVLEHEM-EIQGLLQSVS-TREQESQAAA 663
L + L ++ ++QDL ++ + VL+ E+ ++Q L+ +++ RE+ES+
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
Query: 664 EKLVQ----------ALMERNSEL----QALRQYLGGRDSLMSQAPISNQQAEVTPTGCL 709
++ + + + SEL Q + Y+ L S Q+ + L
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 710 GKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD-TVAGLEKELSNAKEELELMAKK 768
K+ D ++ ++S S K+++ ++TL D L+ LS ++ L + +
Sbjct: 313 KKEQDYTKLEEKHNEESVS---KKNI---QATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 769 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAME 828
E L+ ++ E + Q A+ + L + + KE LQ+Q
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ--HGLQLQ----------- 413
Query: 829 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDER----------SRLNEALQ 878
E+ L K+ E Q E G ++Q L E L+D+ SRL E L+
Sbjct: 414 ---SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK 470
Query: 879 AE----RQLYSSLVKF-HAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLET 933
+ +L L K H E ++ +L AQ + LE+VL + ++ +++
Sbjct: 471 EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ---NDLEQVLRQIGDKDQKIQN 527
Query: 934 LAAI 937
L A+
Sbjct: 528 LEAL 531
Score = 34.7 bits (78), Expect = 0.44
Identities = 19/81 (23%), Positives = 47/81 (58%), Gaps = 1/81 (1%)
Query: 5 YRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQD 64
+++ + +++L+K+ L+ I LE +Q + R + +R ++ + E+E L+ ++ +
Sbjct: 1257 WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD-ERRALLERCLKGEGEIEKLQTKVLE 1315
Query: 65 KKQHLDKTWADVENLNSQNEA 85
++ LD T A V+ L +N++
Sbjct: 1316 LQRKLDNTTAAVQELGRENQS 1336
Score = 30.8 bits (68), Expect = 6.4
Identities = 44/201 (21%), Positives = 78/201 (38%), Gaps = 28/201 (13%)
Query: 11 HLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLD 70
+L D K+ KL + + ++ E + + ++K E E LK+E +K+ L
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH 1219
Query: 71 KTWADVE---NLNSQNEAELRRQF-----------EERQQETEHVYEL------------ 104
+ E + +NEA+L Q +E Q V EL
Sbjct: 1220 SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIA 1279
Query: 105 -LENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGD-QVKPD 162
LE +Q Q+E R + +E + LEL KL T +++ + Q
Sbjct: 1280 VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQI 1339
Query: 163 QYTEALAQRDKRIEELNQSLA 183
++T+AL ++ E+ +A
Sbjct: 1340 KHTQALNRKWAEDNEVQNCMA 1360
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 137 bits (344), Expect = 6e-32
Identities = 208/1009 (20%), Positives = 433/1009 (42%), Gaps = 112/1009 (11%)
Query: 33 MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENL------------- 79
M+++++ +++++ K + K E L +Q+K + A+ ENL
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 80 NSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL- 138
Q EA+++ E + E E EL K +L E S L K+ L + EKE +
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 139 -----ELSEKLKGVTKN------------------WEDVPGDQVKPDQYTEALAQRDKRI 175
L+E+L G+ + +D+ ++ K + + ++ ++++
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 176 EELNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
E+L SL +++L L R K++L L L +E + ++++ ++L ++ K E
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE-SILDLENDKQQLDERLKKKDFEYCQL 1091
Query: 233 QQSVSD----------------SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS 276
Q V D + + EL+E+I+ AT +++ ++ + EL+ E
Sbjct: 1092 QSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 1151
Query: 277 QKQDGTIQNLKETLKSRERETEELYQVIEGQN---------------DTMAKLREMLHQS 321
++ G E K RE E +L + +E D++A+L E +
Sbjct: 1152 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI--D 1209
Query: 322 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 381
L ++ ++ ++ + DL S++ L+++ R E QL++A+ + ++
Sbjct: 1210 NLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Query: 382 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
+ E QK EL + L++ + + S+ +A+ ++ E++ Q + +
Sbjct: 1270 SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF-TQQTEELKRQLEEENKAKN 1328
Query: 442 SLSHKEQLLQEFRELL--QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSAL 499
+L+H Q + +LL QY + + E + L K + E ++ L
Sbjct: 1329 ALAHALQSSRHDCDLLREQYEEEQEGKAEL-QRALSKANSEVAQWRTKYETDAIQRTEEL 1387
Query: 500 EEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQ 559
EE +K+L Q +++ + +E + +S E T Q ++ + ++VE+ ++ L
Sbjct: 1388 EEAKKKLAQ---RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444
Query: 560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR 619
+ + + W+ + E +L+ SL KE LS T L KL E ++L +
Sbjct: 1445 KKQRNFDKVLAEWKTKCEESQAELEASL----KESRSLS-TELFKLKNAYEEALDQL-ET 1498
Query: 620 LQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS---VSTREQESQAAAEKLVQALMERNSE 676
++R+ + L+ ++D +Q+ E+ I L +S + + + Q A E+ AL ++
Sbjct: 1499 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 1558
Query: 677 LQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVS 736
+ ++ L S + + I+ + E+ L + + + S D+ + E +
Sbjct: 1559 ILRIQLELTQVKSEIDR-KIAEKDEEIEQ---LKRNYQRTVETMQSALDAEVRSRNEAIR 1614
Query: 737 IPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMM--AVQ-EEELQVQ 793
+ + GDL+ + E +LS+A + K R Q +L Q + A++ +E+L+ Q
Sbjct: 1615 LKKKMEGDLNEI---EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ 1671
Query: 794 AADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISG 853
A +E R + + +++L+ L E A + QE+L E+V + +Q +
Sbjct: 1672 LAIVE---RRANLLQAEVEELRATLEQTE--RARKLAEQELLDSNERVQLLHTQNTSLIH 1726
Query: 854 NRR--QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911
++ + L+ L+ V++ SR +A AE + ++ E ++++ LE
Sbjct: 1727 TKKKLETDLMQLQSEVEDASR--DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER-- 1782
Query: 912 VLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
++ LE+ + RL+ E LA GG E E +E E
Sbjct: 1783 -MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGE 1830
Score = 86.7 bits (213), Expect = 1e-16
Identities = 131/630 (20%), Positives = 268/630 (42%), Gaps = 96/630 (15%)
Query: 30 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEA--EL 87
++++ Q+ + S E + N + +E K+ LQ + + L DVE NS A +
Sbjct: 1391 KKKLAQRLQDSEEQVEAVNAKC-ASLEKTKQRLQGEVEDL---MVDVERANSLAAALDKK 1446
Query: 88 RRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGV 147
+R F++ E + E + +++ +ESR E ++ E L+ E +K
Sbjct: 1447 QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA----LDQLETVKRE 1502
Query: 148 TKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPT 207
KN E D TE +A+ K I EL +S +Q+ EK + LEE
Sbjct: 1503 NKNLEQEIAD------LTEQIAENGKTIHELEKSR-------KQIELEKADIQLALEEAE 1549
Query: 208 SMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEAT-NKILQEKLNEMS 266
+ + L Q +L ++ I D +AE E+I+Q + + ++ + +
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEI------DRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 267 YELKCAQES---SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQL 323
E++ E+ +K +G + ++ L R+ E T+ LR + Q +
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE----------TLKHLRSVQGQLKD 1653
Query: 324 GQLHSSE---GTSPAQQQVALLDLQSALFCSQLE-----IQKLQRVVRQKERQLADAKQC 375
QLH + G ++Q+A+++ ++ L +++E +++ +R + E++L D+ +
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER 1713
Query: 376 VQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN 435
VQ + Q + ++L L QLQ E+++ S+ R +E+
Sbjct: 1714 VQLLHT-------QNTSLIHTKKKLETDLMQLQSEVEDASRDAR----------NAEEKA 1756
Query: 436 IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEK 495
+ + + E+L +E +D S LE++++ + L+ +DE
Sbjct: 1757 KKAITDAAMMAEELKKE-------QDTSAH--------LERMKKNLEQTVKDLQHRLDEA 1801
Query: 496 FS-ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTT 554
AL+ +K++++L +RE + +LE + + + ++ E ++ + E+
Sbjct: 1802 EQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1861
Query: 555 CQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAE 614
LQ L ++++ K ++++ E +Q L K +L +++IAE
Sbjct: 1862 VLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEE------AEERADIAE 1915
Query: 615 ELCQRLQRKERMLQDLLSDRNKQVLEHEME 644
+L+ K R D S R ++ HE E
Sbjct: 1916 SQVNKLRAKTR---DFTSSR---MVVHESE 1939
Score = 77.8 bits (190), Expect = 5e-14
Identities = 100/438 (22%), Positives = 198/438 (45%), Gaps = 45/438 (10%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L +K+EN +L+ I L E++ + + E SR+ I ++++
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 1544
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE +Q + +E L
Sbjct: 1545 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604
Query: 115 ESRLAKNEAARMAALVEAE-KECNLELS---EKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
E R ++NEA R+ +E + E ++LS + K+ V G Q+K Q A
Sbjct: 1605 EVR-SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQG-QLKDTQLHLDDAL 1662
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSH 227
R + E+L + LA ER L E ++L L E + Q + + + Q L++
Sbjct: 1663 RGQ--EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ 1720
Query: 228 ETT-ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE-------MSYELKCAQESSQKQ 279
T+ I + ++ L +LQ +++ + +EK + M+ ELK Q++S
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1780
Query: 280 DGTIQNLKETLKSRERETEELYQV-IEGQNDTMAKL----REM---LHQSQLGQLHSSEG 331
+ +NL++T+K + +E Q+ ++G + KL RE+ L Q S +G
Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840
Query: 332 TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
+++V L QS + + +LQ +V + + ++ K+ A E+++Q
Sbjct: 1841 LRKYERRVKELTYQSEE--DRKNVLRLQDLVDKLQVKVKSYKR-------QAEEADEQAN 1891
Query: 392 ASWKHNQELRKALQQLQE 409
A H + RKA +L+E
Sbjct: 1892 A---HLTKFRKAQHELEE 1906
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 137 bits (344), Expect = 6e-32
Identities = 217/983 (22%), Positives = 426/983 (43%), Gaps = 106/983 (10%)
Query: 4 GYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASR-EDIYKRNIELKVEVESLKREL 62
G R S L++L+KEN LK +++ +E M++ + + E++ + N+ L E +++
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDME--MERDMDRKKIEELMEENMTL----EMAQKQS 422
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ---EESRLA 119
D+ HL + + +EA + E + T LE + Q L EE R
Sbjct: 423 MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
Query: 120 KNEAARMAA-LVEAEKECNLELSEKLK----GVTKNWEDVPGDQVKPDQYTEALAQRDKR 174
+ A+ +++ EKE N LS+K++ + + + + Q + AQ +K
Sbjct: 483 VDSVEGNASKILKMEKE-NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 175 IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
IE L ++ Q +++EQ + Q + L + + + + +++ K+ K+ T
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 235 SVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLK 291
+S + Q K + K E+ E+ EL ++ ++ I NLK E ++
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEK--GERAEELENELHHLEKENELLQKKITNLKITCEKIE 659
Query: 292 SRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS 351
+ E+E EL + T+ + + Q + + E + ++ + L +L C+
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLE---KENSQLDEENLELRRNVESLKCA 716
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK----HNQELRKALQQL 407
+++ +LQ ++ E + K+ ++ ++A+ ++E+ E S++ NQ L+K L+
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL-EVSYQGLDIENQRLQKTLENS 775
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL 467
+++Q +L+ E E +T ++N++ L S EQL +E + L + L
Sbjct: 776 NKKIQQLESELQDLEMEN----QTLQKNLEELKISSKRLEQLEKENKSL----EQETSQL 827
Query: 468 EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 527
E ++ LEK +R+ +A + ++E + EKE + L + RL+++
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 528 SSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK---EEMETKFSRWQKEQESIIQQLQ 584
N + L++ ++++ L T ++L K ++M + E E I +
Sbjct: 888 KEN-------KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Query: 585 TSLH------DRNKEVED-LSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD---- 633
LH DR K +E L +TL L + +IA L RL+ Q L +
Sbjct: 941 RLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA-ALEARLEESTNYNQQLRQELKTV 999
Query: 634 -RNKQVLEHEMEIQGLLQSV-------STREQESQAAAEKLVQA------LMERNSELQA 679
+N + L+ + + ++QS + E+ESQ +L++ + N+ LQA
Sbjct: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1059
Query: 680 LRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPR 739
+Q L + + + +N QA++ L Q S+Q ++T T + +
Sbjct: 1060 EKQALKTQLKQL-ETQNNNLQAQI-----LALQRQTVSLQ---EQNTTLQTQNAKLQVEN 1110
Query: 740 STLGDLDTV-----AGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQV-- 792
STL T A L + S+ + E E + KERE +L +L + E+L++
Sbjct: 1111 STLNSQSTSLMNQNAQLLIQQSSLENENESVI-KERE---DLKSLYDSLIKDHEKLELLH 1166
Query: 793 --QAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQE 850
QA++ ESL + K+L+++ D ED + L EK+ VE +
Sbjct: 1167 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1226
Query: 851 ISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD-RTLQVELEG 909
+ + + + L E RLN YS L+K E + D + L+ L
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLNHT-------YSQLLK---ETEVLQTDHKNLKSLLNN 1276
Query: 910 AQVLRSRLEEVLGRSLERLNRLE 932
+++ ++RLE + E+ +L+
Sbjct: 1277 SKLEQTRLEAEFSKLKEQYQQLD 1299
Score = 102 bits (255), Expect = 1e-21
Identities = 211/1001 (21%), Positives = 408/1001 (40%), Gaps = 158/1001 (15%)
Query: 35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHL---------DKTWADVENLNSQNEA 85
QK E E I + + K V + +E+ ++++ D + D+E L
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 86 ELRRQFEERQQETEHVYELLENK--IQLLQEESRLAKNEAARMA-ALVEAEKECNLELSE 142
L+R +ER + +E + EL E + + L S A++ E+ + ++EL++
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 143 ---KLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS------ 193
K++ + + E+ + Q E + KR+++ N +L + R
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 194 REKQQLLHLLEEPTSMEVQPM---------TEELLKQQKLNSHETTITQQSVSDSHLAEL 244
REK + LE S + + EEL + ++ T+ + + +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR-- 373
Query: 245 QEKIQQTEATNKILQEKLNEMSYE-----------------LKCAQESSQKQD----GTI 283
+K+ + E N L+ KL++M E L+ AQ+ S + +
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 284 QNLKETLKSRERETEEL-YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 342
+ + T + E + L ++V E + + KL EM +QS + T + + A
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTTVDSVEGNA-- 490
Query: 343 DLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ------------------FVEAAAH 384
S + + E Q+L + V E ++ KQ +Q +E
Sbjct: 491 ---SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 385 ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
SE+Q + + N+ L + + L++ Q S + R + EK N+I ++I+ + LS
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKI--LHESIKETSSKLS 604
Query: 445 HKE-QLLQEFRELLQYRDNSDKTLEANEML--LEKLRQRIHDKAVALERAIDEKFSALEE 501
E + Q +EL Y++ ++ E L LEK + + K L + EK ALE+
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQ 663
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQ--LSTTCQNLQ 559
+ EL + +++ + L L S ++ S L + LE+ + S C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENLELRRNVESLKCASMK 719
Query: 560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR 619
+ ++E KE ES +QL+ L L K ++E E Q
Sbjct: 720 MAQLQLE------NKELESEKEQLKKGLE-------------LLKASFKKTERLEVSYQG 760
Query: 620 LQRKERMLQDLLSDRNKQVLEHEMEIQGL---LQSVSTREQESQAAAEKLVQALMERNSE 676
L + + LQ L + NK++ + E E+Q L Q++ +E + ++++L Q E S
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 677 LQALRQYLGGRDSLMSQAPISNQQAEVTPT---------GCLGKQTDQGSMQIPSRDDS- 726
Q Q + L + QQAE+ T G L K+ S +I +S
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC 880
Query: 727 --TSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAK--KERESQMELSALQSM 782
KE+ + + D+ T+ L ++L + K + + M ++ ++E L
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Query: 783 MAVQEEE-----LQVQAADMES-LTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLL 836
+ +E+ ++ + +ES L ++++IKE+ I L+ +L E ++L QE+
Sbjct: 941 RLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL--EESTNYNQQLRQELKT 998
Query: 837 LREKVASVESQGQE---------ISGNRRQ---------QLLLMLEGLVDERSRLNEALQ 878
+++ +++ + E ISG + + LL ++ + E R N LQ
Sbjct: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
Query: 879 AERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 919
AE+Q + +K + ++ LQ ++ Q L+E
Sbjct: 1059 AEKQALKTQLK-----QLETQNNNLQAQILALQRQTVSLQE 1094
Score = 87.0 bits (214), Expect = 8e-17
Identities = 163/837 (19%), Positives = 354/837 (42%), Gaps = 108/837 (12%)
Query: 5 YRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVE---VESLKRE 61
Y+ L L+K + +I LE +Q E + + K ELK+ +E L++E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQD-LEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 62 LQDKKQHLDKTWADVENLNSQNEAELRRQFEERQ---QETEHVYELLENKIQLLQEESRL 118
+ +Q + D + L +N+ LR+Q E + +E LE + + L +E +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENK-RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 119 AKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEEL 178
K R+ L + KE + +K + ED+ +++K Q L + +E++
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 179 NQSLAAQERLV--EQLSREKQQLLHLLEEPT---SMEVQPMTEELLKQQKLNSHETTITQ 233
+ +ERL+ EQ + ++ +LL E T S+E+ K++K+ + E + +
Sbjct: 936 GLN---KERLLHDEQSTDDRYKLLESKLESTLKKSLEI--------KEEKIAALEARLEE 984
Query: 234 QSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSR 293
+ + L + + +++ K Q++ + + E ++ + + + +E LK +
Sbjct: 985 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 294 ERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ------QQVALLDLQSA 347
+R E +E N T+ ++ L ++QL QL + AQ Q V+L + +
Sbjct: 1045 DRLIE-----VERNNATLQAEKQAL-KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1098
Query: 348 LFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQL 407
L ++Q + + L + + +++ E + E+ K ++L+ L
Sbjct: 1099 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL---ENENESVIKEREDLKSLYDSL 1155
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQ--HLNHSLSHKEQLLQEFRELLQYR---DN 462
++ K + L +A +Y + ++ ++ H N + H++ L + +LL+ + ++
Sbjct: 1156 IKD-HEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD-LEDRYNQLLKQKGQLED 1213
Query: 463 SDKTL--EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL 520
+K L E +MLLE + H+ A + + + L +L + V + DH
Sbjct: 1214 LEKMLKVEQEKMLLEN---KNHETVAAEYKKLCGENDRLNHTYSQLLK-ETEVLQTDH-- 1267
Query: 521 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESII 580
+ L+ +L++++ +E+ + +QL T L E + ++E ++
Sbjct: 1268 KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL 1327
Query: 581 QQLQT------SLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDR 634
Q+QT +L ++N E +DL Q + ++L L+R++ L++ + D+
Sbjct: 1328 DQIQTLMLQNRTLLEQNMESKDL-------FHVEQRQYIDKL-NELRRQKEKLEEKIMDQ 1379
Query: 635 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQA 694
K +G ++ R KL+++ + N E Q
Sbjct: 1380 YKFYDPSPPRRRGNWITLKMR---------KLIKSKKDINRERQ---------------- 1414
Query: 695 PISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKE 754
+ +TPT + +G +Q+P +D +++ S+ ++L D T+ G +K
Sbjct: 1415 ----KSLTLTPT---RSDSSEGFLQLPHQD------SQDSSSVGSNSLEDGQTL-GTKKS 1460
Query: 755 LSNAKEELELMAKKERE-SQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDL 810
A + L + + ++ +M+ +SM + V A T N+++ +D+
Sbjct: 1461 SMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDI 1517
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 136 bits (343), Expect = 8e-32
Identities = 208/968 (21%), Positives = 411/968 (42%), Gaps = 177/968 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1134
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1135 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1247 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1272
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1331
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1332 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1373
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1488
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1489 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1537
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1656
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1768
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1769 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKF 890
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E S ++
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGREVNALKSKLRG 1937
Query: 891 HAHPESSE 898
E+S+
Sbjct: 1938 PPPQETSQ 1945
Score = 124 bits (312), Expect = 3e-28
Identities = 217/1029 (21%), Positives = 413/1029 (40%), Gaps = 168/1029 (16%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 920 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 977
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1033
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1034 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1202
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1263 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1440 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1491 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIP------------------------------RSTLGD 744
+ Q+ +D L A ED + + L +
Sbjct: 1550 EMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 745 LDT-----------VAGLEKELSNAKEELELMA----KKERESQMELSALQSMMAVQEEE 789
+T A +K+L ++LEL A K E+ +L LQ+ M + E
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVD-PEDIPAMERLTQEVLLLREKVASVESQG 848
L+ A + + + E K L+ L+ ED+ A ER ++ L +E++A E
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA--EELA 1725
Query: 849 QEISG--------NRRQQLLLMLEGLVDER--------SRLNEALQAERQLYSSLVKFHA 892
+SG R + + LE ++E R+ +A Q QL + L +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 893 HPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTE 952
+ +E R Q+E + + LRS+L E+ G + T+AA+ E +
Sbjct: 1786 TAQKNESARQ-QLERQNKE-LRSKLHEMEGAVKSKFK--STIAAL---------EAKIAQ 1832
Query: 953 FTDSIEEEA 961
+ +E+EA
Sbjct: 1833 LEEQVEQEA 1841
Score = 100 bits (249), Expect = 7e-21
Identities = 173/787 (21%), Positives = 333/787 (42%), Gaps = 114/787 (14%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 873
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 922
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 923 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 965
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1016
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1017 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1186 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1237
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1289
Query: 697 SNQQAEV-TPTGCLGKQTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
Q EV + TG L + + + + S T + R L + LE
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 753 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 812
+E ++ +++L+ + ++ + +S L ++ +++LQ A+ +E+L E+ K
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKK 1402
Query: 813 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
Q ++ E LTQ+ EK A+ + E + NR QQ L L +D + +
Sbjct: 1403 RFQKEI---------ENLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRS 924
L L+ +++ + L+ + S D + E E A L LEE L
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 925 LERLNRL 931
LER N++
Sbjct: 1509 LERTNKM 1515
Score = 85.9 bits (211), Expect = 2e-16
Identities = 121/623 (19%), Positives = 262/623 (42%), Gaps = 67/623 (10%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKK 66
TL+ L+D KK+ + LEE +++++ E++ ++ E + L++ +
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 67 QHLDKTWADVENLNS--QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 124
Q LD D++N N + +R+F++ E +++ ++ + E+R + +A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 125 RMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA 184
+A +E E EL K + ED+ K D K + EL +S A
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSS--KDDV--------GKNVHELEKSKRA 1543
Query: 185 QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
E +E++ + ++L E+Q + L+ + + Q++ +L
Sbjct: 1544 LETQMEEMKTQLEEL--------EDELQATEDAKLRLE--------VNMQALKGQFERDL 1587
Query: 245 QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
Q + +Q E + LQ +L+E EL+ ++ + L+ LK E + + I
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS---AI 1644
Query: 305 EGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 364
+G+ + + +LR++ Q + Q + + + +F + E +K + +
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDE----------IFATAKENEKKAKSL-- 1692
Query: 365 KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE 424
E L ++ + E A +++ +KE + +EL +L + LQ++ ++L A A+
Sbjct: 1693 -EADLMQLQEDLAAAERARKQADLEKE---ELAEELASSLSG-RNALQDEKRRLEARIAQ 1747
Query: 425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRDNSDKTLEANEMLLEKLRQRIHD 483
E+ ++ N++ ++ + Q ++ EL R + K A + L E+ + +
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRS 1806
Query: 484 KAVALERAIDEKF----SALEEK--------EKELRQLRLAVRERDHDLERLRDVLSSNE 531
K +E A+ KF +ALE K E+E R+ + A + ++L+++L E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 532 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRN 591
+ E + E+ + + L+ EE E + R + + ++L +
Sbjct: 1867 DERKMAEQYKE----QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 592 KEVEDLSATLLCKLGPGQSEIAE 614
+++A GP E ++
Sbjct: 1923 AMGREVNALKSKLRGPPPQETSQ 1945
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 136 bits (343), Expect = 8e-32
Identities = 208/968 (21%), Positives = 411/968 (42%), Gaps = 177/968 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1127
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1128 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1240 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1265
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1324
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1325 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1366
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1481
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1482 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1530
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1649
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1761
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1762 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKF 890
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E S ++
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGREVNALKSKLRG 1930
Query: 891 HAHPESSE 898
E+S+
Sbjct: 1931 PPPQETSQ 1938
Score = 124 bits (312), Expect = 3e-28
Identities = 217/1029 (21%), Positives = 413/1029 (40%), Gaps = 168/1029 (16%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 913 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 970
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1026
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1027 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1195
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1256 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1433 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1484 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIP------------------------------RSTLGD 744
+ Q+ +D L A ED + + L +
Sbjct: 1543 EMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 745 LDT-----------VAGLEKELSNAKEELELMA----KKERESQMELSALQSMMAVQEEE 789
+T A +K+L ++LEL A K E+ +L LQ+ M + E
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVD-PEDIPAMERLTQEVLLLREKVASVESQG 848
L+ A + + + E K L+ L+ ED+ A ER ++ L +E++A E
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA--EELA 1718
Query: 849 QEISG--------NRRQQLLLMLEGLVDER--------SRLNEALQAERQLYSSLVKFHA 892
+SG R + + LE ++E R+ +A Q QL + L +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 893 HPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTE 952
+ +E R Q+E + + LRS+L E+ G + T+AA+ E +
Sbjct: 1779 TAQKNESARQ-QLERQNKE-LRSKLHEMEGAVKSKFK--STIAAL---------EAKIAQ 1825
Query: 953 FTDSIEEEA 961
+ +E+EA
Sbjct: 1826 LEEQVEQEA 1834
Score = 100 bits (249), Expect = 7e-21
Identities = 173/787 (21%), Positives = 333/787 (42%), Gaps = 114/787 (14%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 866
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 915
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 916 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 958
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1009
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1010 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1179 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1230
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1282
Query: 697 SNQQAEV-TPTGCLGKQTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
Q EV + TG L + + + + S T + R L + LE
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 753 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 812
+E ++ +++L+ + ++ + +S L ++ +++LQ A+ +E+L E+ K
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKK 1395
Query: 813 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
Q ++ E LTQ+ EK A+ + E + NR QQ L L +D + +
Sbjct: 1396 RFQKEI---------ENLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRS 924
L L+ +++ + L+ + S D + E E A L LEE L
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 925 LERLNRL 931
LER N++
Sbjct: 1502 LERTNKM 1508
Score = 85.9 bits (211), Expect = 2e-16
Identities = 121/623 (19%), Positives = 262/623 (42%), Gaps = 67/623 (10%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKK 66
TL+ L+D KK+ + LEE +++++ E++ ++ E + L++ +
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 67 QHLDKTWADVENLNS--QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 124
Q LD D++N N + +R+F++ E +++ ++ + E+R + +A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 125 RMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA 184
+A +E E EL K + ED+ K D K + EL +S A
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSS--KDDV--------GKNVHELEKSKRA 1536
Query: 185 QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
E +E++ + ++L E+Q + L+ + + Q++ +L
Sbjct: 1537 LETQMEEMKTQLEEL--------EDELQATEDAKLRLE--------VNMQALKGQFERDL 1580
Query: 245 QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
Q + +Q E + LQ +L+E EL+ ++ + L+ LK E + + I
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS---AI 1637
Query: 305 EGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 364
+G+ + + +LR++ Q + Q + + + +F + E +K + +
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDE----------IFATAKENEKKAKSL-- 1685
Query: 365 KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE 424
E L ++ + E A +++ +KE + +EL +L + LQ++ ++L A A+
Sbjct: 1686 -EADLMQLQEDLAAAERARKQADLEKE---ELAEELASSLSG-RNALQDEKRRLEARIAQ 1740
Query: 425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRDNSDKTLEANEMLLEKLRQRIHD 483
E+ ++ N++ ++ + Q ++ EL R + K A + L E+ + +
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRS 1799
Query: 484 KAVALERAIDEKF----SALEEK--------EKELRQLRLAVRERDHDLERLRDVLSSNE 531
K +E A+ KF +ALE K E+E R+ + A + ++L+++L E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 532 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRN 591
+ E + E+ + + L+ EE E + R + + ++L +
Sbjct: 1860 DERKMAEQYKE----QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 592 KEVEDLSATLLCKLGPGQSEIAE 614
+++A GP E ++
Sbjct: 1916 AMGREVNALKSKLRGPPPQETSQ 1938
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 135 bits (341), Expect = 1e-31
Identities = 202/1014 (19%), Positives = 418/1014 (41%), Gaps = 122/1014 (12%)
Query: 33 MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQN--------- 83
M++ +E ++E++ + K E + LQ+K + ++ ENL
Sbjct: 856 MKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKS 915
Query: 84 ----EAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL- 138
EA+++ E ++E E EL+ K L + S L ++ L + EKE +
Sbjct: 916 KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT 975
Query: 139 -----ELSEKLKGVTKN------------------WEDVPGDQVKPDQYTEALAQRDKRI 175
LSE++ + +N +D+ ++ K + + A+ +++
Sbjct: 976 ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 176 EELNQSLAAQERLVEQLSREKQQLLHLLE--EPTSMEVQPMTEELLKQQKLNSHETTITQ 233
++L SL +++L L R K++L L+ + + M+++ +++ ++ K E + Q
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 234 QSVSDS--HLAELQEKIQQTEATNKILQEKL--------------NEMSYELKCAQESSQ 277
+ D H + Q+KI++ +A + L+E++ ++++ EL+ E +
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 278 KQDGTIQNLKETLKSRERETEELYQVIE---------------GQNDTMAKLREMLHQSQ 322
+ G E K RE E +++ + +E Q D++A+L E + Q
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 323 LGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAA 382
+ + S + ++ D+ S + ++R R E Q ++ K +
Sbjct: 1216 RVKQKLEKEKSELKMEID--DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 383 AHESEQQKEASWKHNQEL-------RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN 435
H+ QK N EL + QL + Q +QQL E ++ E T+ +N
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE--ELKRQMEEETKAKN 1331
Query: 436 -IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE 494
+ H S H LL+E QY + + E + L K + E +
Sbjct: 1332 AMAHALQSSRHDCDLLRE-----QYEEEQEAKAEL-QRALSKANSEVAQWRTKYETDAIQ 1385
Query: 495 KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTT 554
+ LEE +K+L Q ++E + + E +S E T Q ++ + ++E+ T
Sbjct: 1386 RTEELEEAKKKLAQ---RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 555 CQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAE 614
C L + + + W+++ + + Q L KE LS T L K+ E+ +
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQK----LDESQAELEAAQKESRSLS-TELFKMRNAYEEVVD 1497
Query: 615 ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQES---QAAAEKLVQALM 671
+L + L+R+ + LQ+ +SD +Q+ E +Q ++ EQE Q A E++ +L
Sbjct: 1498 QL-ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556
Query: 672 ERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTA 731
S++ ++ L S + + I + E+ L + + + + + S D+ +
Sbjct: 1557 HEESKILRVQLELSQVKSELDRKVIEKDE-EIEQ---LKRNSQRAAEALQSVLDAEIRSR 1612
Query: 732 KEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQ 791
+ + + + GDL+ +E +L ++ ++ E+Q L +Q + + L
Sbjct: 1613 NDALRLKKKMEGDLNE---MEIQLGHSNRQM-------AETQKHLRTVQGQLKDSQLHLD 1662
Query: 792 VQAADMESLTRNIQIKED----LIKDLQMQLVDPEDIPAMERLT-QEVLLLREKVASVES 846
E L + I E L+++L+ V E RL+ QE+L ++V + S
Sbjct: 1663 DALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHS 1722
Query: 847 QGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE 906
Q + +++ + + + + + E+ AE + ++ E ++++
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 907 LEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
LE ++ LE+ + RL+ E LA GG E+ E + ++ E
Sbjct: 1783 LER---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVE 1833
Score = 76.3 bits (186), Expect = 1e-13
Identities = 97/461 (21%), Positives = 195/461 (42%), Gaps = 59/461 (12%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQ------QKYEASREDIYKRNIELKVE 54
M N Y + L L++EN +L+ I L E++ Q+ E +++ + + +L+V
Sbjct: 1488 MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA 1547
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ- 113
+E ++ L+ ++ + + ++ SQ ++EL R+ E+ +E E + + + LQ
Sbjct: 1548 LEEVEGSLEHEESKILRVQLEL----SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603
Query: 114 --EESRLAKNEAARMAALVEA---EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEAL 168
+ ++N+A R+ +E E E L S + T+ Q+K Q
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL---- 1659
Query: 169 AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHE 228
L+ +L + E L EQL+ +++ LLEE M+V + E
Sbjct: 1660 --------HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV--------------ALE 1697
Query: 229 TTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 288
T + +S+ L + +++Q + N L ++ ++ Q + +N +E
Sbjct: 1698 QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 289 TLKSRERETEELYQVIEGQNDTMAKLREM---LHQSQLGQLHSSEGTSPAQQQVALLDLQ 345
K + + + ++ + DT A L M L Q+ H + Q
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE-----------Q 1806
Query: 346 SALFCSQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRK-- 402
AL + +IQKL+ VR+ E +L + K+ + ++ A + KE +++ ++ +
Sbjct: 1807 LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL 1866
Query: 403 ALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL 443
LQ L ++LQ K + + E + TQ + + H L
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 135 bits (340), Expect = 2e-31
Identities = 205/950 (21%), Positives = 404/950 (42%), Gaps = 177/950 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1127
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1128 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1240 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1265
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1324
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1325 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1366
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1481
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1482 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1530
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1649
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1761
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1762 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 880
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGRE 1920
Score = 124 bits (312), Expect = 3e-28
Identities = 217/1029 (21%), Positives = 413/1029 (40%), Gaps = 168/1029 (16%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 913 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 970
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1026
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1027 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1195
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1256 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1433 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1484 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIP------------------------------RSTLGD 744
+ Q+ +D L A ED + + L +
Sbjct: 1543 EMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 745 LDT-----------VAGLEKELSNAKEELELMA----KKERESQMELSALQSMMAVQEEE 789
+T A +K+L ++LEL A K E+ +L LQ+ M + E
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVD-PEDIPAMERLTQEVLLLREKVASVESQG 848
L+ A + + + E K L+ L+ ED+ A ER ++ L +E++A E
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA--EELA 1718
Query: 849 QEISG--------NRRQQLLLMLEGLVDER--------SRLNEALQAERQLYSSLVKFHA 892
+SG R + + LE ++E R+ +A Q QL + L +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 893 HPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTE 952
+ +E R Q+E + + LRS+L E+ G + T+AA+ E +
Sbjct: 1779 TAQKNESARQ-QLERQNKE-LRSKLHEMEGAVKSKFK--STIAAL---------EAKIAQ 1825
Query: 953 FTDSIEEEA 961
+ +E+EA
Sbjct: 1826 LEEQVEQEA 1834
Score = 100 bits (249), Expect = 7e-21
Identities = 173/787 (21%), Positives = 333/787 (42%), Gaps = 114/787 (14%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 866
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 915
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 916 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 958
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1009
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1010 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1179 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1230
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1282
Query: 697 SNQQAEV-TPTGCLGKQTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
Q EV + TG L + + + + S T + R L + LE
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 753 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 812
+E ++ +++L+ + ++ + +S L ++ +++LQ A+ +E+L E+ K
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKK 1395
Query: 813 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
Q ++ E LTQ+ EK A+ + E + NR QQ L L +D + +
Sbjct: 1396 RFQKEI---------ENLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRS 924
L L+ +++ + L+ + S D + E E A L LEE L
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 925 LERLNRL 931
LER N++
Sbjct: 1502 LERTNKM 1508
Score = 84.3 bits (207), Expect = 5e-16
Identities = 121/613 (19%), Positives = 259/613 (42%), Gaps = 70/613 (11%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKK 66
TL+ L+D KK+ + LEE +++++ E++ ++ E + L++ +
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 67 QHLDKTWADVENLNS--QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 124
Q LD D++N N + +R+F++ E +++ ++ + E+R + +A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 125 RMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA 184
+A +E E EL K + ED+ K D K + EL +S A
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSS--KDDV--------GKNVHELEKSKRA 1536
Query: 185 QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
E +E++ + ++L E+Q + L+ + + Q++ +L
Sbjct: 1537 LETQMEEMKTQLEEL--------EDELQATEDAKLRLE--------VNMQALKGQFERDL 1580
Query: 245 QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
Q + +Q E + LQ +L+E EL+ ++ + L+ LK E + + I
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS---AI 1637
Query: 305 EGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 364
+G+ + + +LR++ Q + Q + + + +F + E +K + +
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDE----------IFATAKENEKKAKSL-- 1685
Query: 365 KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE 424
E L ++ + E A +++ +KE + +EL +L + LQ++ ++L A A+
Sbjct: 1686 -EADLMQLQEDLAAAERARKQADLEKE---ELAEELASSLSG-RNALQDEKRRLEARIAQ 1740
Query: 425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRDNSDKTLEANEMLLEKLRQRIHD 483
E+ ++ N++ ++ + Q ++ EL R + K A + L E+ + +
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRS 1799
Query: 484 KAVALERAIDEKF----SALEEK--------EKELRQLRLAVRERDHDLERLRDVLSSNE 531
K +E A+ KF +ALE K E+E R+ + A + ++L+++L E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 532 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDR- 590
+ E + E+ + + L+ EE E + R + + ++L +
Sbjct: 1860 DERKMAEQYKE----QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 591 --NKEVEDLSATL 601
+EV L + L
Sbjct: 1916 AMGREVNALKSKL 1928
Score = 77.0 bits (188), Expect = 8e-14
Identities = 83/424 (19%), Positives = 187/424 (44%), Gaps = 27/424 (6%)
Query: 38 EASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQE 97
E S+ + + E+K ++E L+ ELQ + + +++ L Q E +L+ + E+ +++
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 98 TEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGD 157
+ L L++E + AA L K+ L+ +KG + + +
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 158 QVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLL------EEPTSMEV 211
Q + + L +E+ + E+ + L + QL L + +E
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 212 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 271
+ + EEL L+ ++ ++ +A+L+E++++ + + + +++ K
Sbjct: 1711 EELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR------KA 1762
Query: 272 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG 331
Q++ Q + N T +S ++ E Q +E QN +LR LH+ + G + S
Sbjct: 1763 TQQAEQ-----LSNELATERSTAQKNESARQQLERQN---KELRSKLHEME-GAVKSKFK 1813
Query: 332 TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
++ A + + L+ + E Q + ++QK+++L K+ + VE +EQ KE
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---KEILLQVEDERKMAEQYKE 1870
Query: 392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ 451
+ K N +++ +QL EE + +SQ++ A + E+ ++ + + ++ + L+
Sbjct: 1871 QAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Query: 452 EFRE 455
E
Sbjct: 1930 RGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 135 bits (340), Expect = 2e-31
Identities = 205/950 (21%), Positives = 404/950 (42%), Gaps = 177/950 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1134
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1135 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1247 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1272
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1331
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1332 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1373
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1488
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1489 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1537
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1656
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1768
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1769 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 880
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGRE 1927
Score = 124 bits (312), Expect = 3e-28
Identities = 217/1029 (21%), Positives = 413/1029 (40%), Gaps = 168/1029 (16%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 920 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 977
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1033
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1034 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1202
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1263 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1440 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1491 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIP------------------------------RSTLGD 744
+ Q+ +D L A ED + + L +
Sbjct: 1550 EMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 745 LDT-----------VAGLEKELSNAKEELELMA----KKERESQMELSALQSMMAVQEEE 789
+T A +K+L ++LEL A K E+ +L LQ+ M + E
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVD-PEDIPAMERLTQEVLLLREKVASVESQG 848
L+ A + + + E K L+ L+ ED+ A ER ++ L +E++A E
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA--EELA 1725
Query: 849 QEISG--------NRRQQLLLMLEGLVDER--------SRLNEALQAERQLYSSLVKFHA 892
+SG R + + LE ++E R+ +A Q QL + L +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 893 HPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTE 952
+ +E R Q+E + + LRS+L E+ G + T+AA+ E +
Sbjct: 1786 TAQKNESARQ-QLERQNKE-LRSKLHEMEGAVKSKFK--STIAAL---------EAKIAQ 1832
Query: 953 FTDSIEEEA 961
+ +E+EA
Sbjct: 1833 LEEQVEQEA 1841
Score = 100 bits (249), Expect = 7e-21
Identities = 173/787 (21%), Positives = 333/787 (42%), Gaps = 114/787 (14%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 873
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 922
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 923 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 965
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1016
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1017 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1186 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1237
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1289
Query: 697 SNQQAEV-TPTGCLGKQTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
Q EV + TG L + + + + S T + R L + LE
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 753 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 812
+E ++ +++L+ + ++ + +S L ++ +++LQ A+ +E+L E+ K
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKK 1402
Query: 813 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
Q ++ E LTQ+ EK A+ + E + NR QQ L L +D + +
Sbjct: 1403 RFQKEI---------ENLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRS 924
L L+ +++ + L+ + S D + E E A L LEE L
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 925 LERLNRL 931
LER N++
Sbjct: 1509 LERTNKM 1515
Score = 84.3 bits (207), Expect = 5e-16
Identities = 121/613 (19%), Positives = 259/613 (42%), Gaps = 70/613 (11%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKK 66
TL+ L+D KK+ + LEE +++++ E++ ++ E + L++ +
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 67 QHLDKTWADVENLNS--QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 124
Q LD D++N N + +R+F++ E +++ ++ + E+R + +A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 125 RMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA 184
+A +E E EL K + ED+ K D K + EL +S A
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSS--KDDV--------GKNVHELEKSKRA 1543
Query: 185 QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
E +E++ + ++L E+Q + L+ + + Q++ +L
Sbjct: 1544 LETQMEEMKTQLEEL--------EDELQATEDAKLRLE--------VNMQALKGQFERDL 1587
Query: 245 QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
Q + +Q E + LQ +L+E EL+ ++ + L+ LK E + + I
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS---AI 1644
Query: 305 EGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 364
+G+ + + +LR++ Q + Q + + + +F + E +K + +
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDE----------IFATAKENEKKAKSL-- 1692
Query: 365 KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE 424
E L ++ + E A +++ +KE + +EL +L + LQ++ ++L A A+
Sbjct: 1693 -EADLMQLQEDLAAAERARKQADLEKE---ELAEELASSLSG-RNALQDEKRRLEARIAQ 1747
Query: 425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRDNSDKTLEANEMLLEKLRQRIHD 483
E+ ++ N++ ++ + Q ++ EL R + K A + L E+ + +
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRS 1806
Query: 484 KAVALERAIDEKF----SALEEK--------EKELRQLRLAVRERDHDLERLRDVLSSNE 531
K +E A+ KF +ALE K E+E R+ + A + ++L+++L E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 532 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDR- 590
+ E + E+ + + L+ EE E + R + + ++L +
Sbjct: 1867 DERKMAEQYKE----QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 591 --NKEVEDLSATL 601
+EV L + L
Sbjct: 1923 AMGREVNALKSKL 1935
Score = 77.0 bits (188), Expect = 8e-14
Identities = 83/424 (19%), Positives = 187/424 (44%), Gaps = 27/424 (6%)
Query: 38 EASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQE 97
E S+ + + E+K ++E L+ ELQ + + +++ L Q E +L+ + E+ +++
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 98 TEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGD 157
+ L L++E + AA L K+ L+ +KG + + +
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 158 QVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLL------EEPTSMEV 211
Q + + L +E+ + E+ + L + QL L + +E
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 212 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 271
+ + EEL L+ ++ ++ +A+L+E++++ + + + +++ K
Sbjct: 1718 EELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR------KA 1769
Query: 272 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG 331
Q++ Q + N T +S ++ E Q +E QN +LR LH+ + G + S
Sbjct: 1770 TQQAEQ-----LSNELATERSTAQKNESARQQLERQN---KELRSKLHEME-GAVKSKFK 1820
Query: 332 TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
++ A + + L+ + E Q + ++QK+++L K+ + VE +EQ KE
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---KEILLQVEDERKMAEQYKE 1877
Query: 392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ 451
+ K N +++ +QL EE + +SQ++ A + E+ ++ + + ++ + L+
Sbjct: 1878 QAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Query: 452 EFRE 455
E
Sbjct: 1937 RGNE 1940
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 135 bits (340), Expect = 2e-31
Identities = 223/1053 (21%), Positives = 451/1053 (42%), Gaps = 175/1053 (16%)
Query: 30 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRR 89
++ +Q++++AS E+ + L+ +V LK+ L++ ++D + L Q AE+
Sbjct: 203 KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD-VLKPLPQLEPQ--AEVFT 259
Query: 90 QFEERQQETEHVYE--LLENKIQLLQEESRLAKNEAARMAALVEAEKE-CNLELSEKLKG 146
+ E + + E V E ++ LQ+ + +N R +++ KE C L SEK
Sbjct: 260 KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK--- 316
Query: 147 VTKNWEDVPGDQVKPDQYTEALAQR-DKRIEELNQ----SLAAQERLVEQLSREKQQLLH 201
EAL ++ D+R++EL + +A + +L+ QL R+ + L+
Sbjct: 317 -------------------EALQEQLDERLQELEKIKDLHMAEKTKLITQL-RDAKNLIE 356
Query: 202 LLEEPTSMEVQPMTEEL-----LKQQKLNSHETTITQQSVSDSHLAELQEKIQQT----- 251
LE+ M + ++ +K++++ + I Q + L E +EK ++
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 252 -------EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
+ T + ++ EM ++K +++S+++ ++Q + R +E+ V+
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ------QELSRVKQEVVDVM 470
Query: 305 EGQNDTMAKLREMLHQSQLGQ--------LHSSEGTSPAQQQVALLDLQS---------- 346
+ ++ + LH+ +L + L + E Q +VAL QS
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKE 530
Query: 347 ---ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASW--------- 394
+L +LE+QK + ++ + E +L D +Q + E E E S
Sbjct: 531 QQESLALEELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD 589
Query: 395 ----------KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN-IQHLNHSL 443
KHN+E+ +++ + EL++ Q A EK ++ Q Q ++ L
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 444 SHKEQLLQEFRELL---QYRDNSDKTLE---ANEMLLEKLRQRIHDKAVALERAIDEKFS 497
+++ L + +E++ + ++KTLE + LE L + + A + ++E+ S
Sbjct: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK-LEEELS 708
Query: 498 ALEEKEKELRQLRLAV--RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC 555
L+++ +++Q A +++H +++ ++ +E ++Q E L+ + ++E L
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK-- 766
Query: 556 QNLQWLKE--------EMETKFSRWQKEQES----IIQQLQTSLHDRNKEVEDLSATLLC 603
+ + LKE E + K S + +Q S + Q Q++ H++ K E+ A L
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 604 KLGPGQSE-------IAE------ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQ 650
KL ++E +AE ++C L + +QDL+ KQ E E +++ L Q
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 651 SVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLG 710
++ ++ E+ Q L+E+ + + +R+ +++Q A+ L
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ----KLSAKEDSIHILN 942
Query: 711 KQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKER 770
++ + + + AKE + L LD A L+KEL N EL K+
Sbjct: 943 EEYETKFKNQEKKMEKVKQKAKEMQETLKKKL--LDQEAKLKKELENTALELSQKEKQFN 1000
Query: 771 ESQMELS---------ALQSMMAVQEEELQ-VQAADMESLTRNIQIKEDLIKDLQMQLVD 820
+E++ A+ + Q+E+++ + L I I E + +L +
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 821 PEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 880
+I E+ QEV L++K+ + +E++ +++ + E V + + LNE
Sbjct: 1061 IHEIQLQEK-EQEVAELKQKILLFGCEKEEMN----KEITWLKEEGVKQDTTLNE----- 1110
Query: 881 RQLYSSLVKFHAHPESSERDRT-LQVELEGAQVLRSRLEEVLGRSLERLNRL-ETLAAIG 938
L L + AH S +D T L+ LE +LE L +SL+ L E L +
Sbjct: 1111 --LQEQLKQKSAHVNSLAQDETKLKAHLE-------KLEVDLNKSLKENTFLQEQLVELK 1161
Query: 939 GAAAGDD---TEDTSTEFTDSIEEEAAHHSHQQ 968
A D +E TS T E ++ SH++
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Score = 107 bits (268), Expect = 4e-23
Identities = 198/920 (21%), Positives = 368/920 (40%), Gaps = 195/920 (21%)
Query: 81 SQNEAELRRQFEERQ------QETEHVYELLENKIQ--------LLQEESRLAKNEAARM 126
S+ EA+LR+ EE+ Q+ H E EN+I+ L+ E+ L K +
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQ 1331
Query: 127 AALVEAEK---ECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE---LNQ 180
A E E + ELSE + VT E++ +V+ ++ L + +++ L++
Sbjct: 1332 QAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE 1391
Query: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
AA L +Q EK +LL +++ S +V +++E + + + Q +
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQD-LSFKVDTLSKEKI---------SALEQVDDWSNK 1441
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
+E ++K Q + Q + E+ +L+ + + ++D I LKE L + + + L
Sbjct: 1442 FSEWKKKAQSRFTQH---QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCL 1498
Query: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
+E M K L T Q +++L+ + +EI+ L
Sbjct: 1499 KGEMEDDKSKMEKKESNLE------------TELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 361 VVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLR 419
V++ +Q + K+ VQ ++ H QEL + +E + K L
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQ---------------HFQELGEEKDNRVKEAEEKILTLE 1591
Query: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
E+ T+++ ++H+N S+ KE+ L+ + L+ + L +L++
Sbjct: 1592 NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE---------SESAAKLAELKR 1642
Query: 480 RIHDKAVALERAIDEKFSALEEKEKE--------LRQLRLAVRERDHDL----ERLRDVL 527
+ K A+++ + S +EEKE++ L +L ++ER+ ++ E+L+ V
Sbjct: 1643 KAEQKIAAIKKQL---LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 528 SSNEAT---------------------------------------MQSMESLLRAKGLEV 548
SS T + E LL+ G E
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK 1759
Query: 549 EQLSTTCQNLQWLKEEMETKFSR---WQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 605
E+ ++ ++ +E K Q E +S+I LQ L ++NK+ + A + K
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKE 1819
Query: 606 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 665
G G++ I + ++ L+++ D K + E E+ Q L Q + +E +S +K
Sbjct: 1820 G-GKNNI---------QAKQNLENVFDDVQKTLQEKELTCQILEQKI--KELDSCLVRQK 1867
Query: 666 LV-----QALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
V + L + +LQAL+Q + GR+ PT L + T++ S
Sbjct: 1868 EVHRVEMEELTSKYEKLQALQQ-MDGRNK---------------PTELLEENTEEKS--- 1908
Query: 721 PSRDDSTSLTAKEDVSIPRSTLGDLD-TVAGLEKELSNAKEELELMAKK----ERESQME 775
+ L + +S + DL+ +AG E+E +E+ + K +E Q E
Sbjct: 1909 -----KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVL 835
L L+ + EE Q + L N +K+ L+++ QL E +E +E +
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQ-LMREFNTQLAQKEQ--ELEMTIKETI 2020
Query: 836 LLREKVASVESQGQEISGNRRQQLLLML----EGLVDERSRLNEALQAERQLYSSLVKFH 891
K VE++ E QLL + + L R E L A +
Sbjct: 2021 ---NKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE--------- 2068
Query: 892 AHPESSERDRTLQVELEGAQ 911
E + + R LQ +LE Q
Sbjct: 2069 ---EMTAKVRDLQTQLEELQ 2085
Score = 105 bits (263), Expect = 2e-22
Identities = 192/983 (19%), Positives = 414/983 (42%), Gaps = 153/983 (15%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK- 65
+L Q L+ +K+E + + EE++ + + +++ ++ EL ++++ +RE Q++
Sbjct: 454 SLQQELSRVKQEVVDVMKKSS--EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
K L+K+ ++ ++ + E + EE + + + + ENK++ LQ+E+ +
Sbjct: 512 KVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILE 571
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
+ + +E + N S+ L A+++K +E+ +
Sbjct: 572 LESSLEKSLQENKNQSKDLA-------------------VHLEAEKNKHNKEITVMVEKH 612
Query: 186 ERLVEQLSREKQQL----LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVS-DSH 240
+ +E L ++ L L +L++ E++ + E+ +Q+K ET + + + +H
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC-EQEK----ETLLKDKEIIFQAH 667
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
+ E+ EK EKL+ EL+ L E LK+R + EEL
Sbjct: 668 IEEMNEKTL----------EKLDVKQTELESLSSE----------LSEVLKARHKLEEEL 707
Query: 301 YQVIEGQNDTM-----AKLREML--HQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQL 353
V++ Q D M AK+ E HQ Q+ + S + + AL D
Sbjct: 708 -SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD---------- 756
Query: 354 EIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQN 413
+I +L+ +++++++ L + + V+ +EA SE + LQQ +L
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE--------------LQQASAKLD- 801
Query: 414 KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQ----LLQEFRELLQYRDNSDKTLEA 469
+++++ + + + E+ + L L E L ++ E+ + + L+A
Sbjct: 802 ---VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858
Query: 470 NEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQL-RLAVRERDHDLERLRDVLS 528
+++ ++ L Q++ +++ S +E+K K L Q+ + + + + E+ + +L
Sbjct: 859 HKIQVQDLMQQL-----------EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 907
Query: 529 SNE-ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587
E +Q E + + ++LS ++ L EE ETKF +K+ E + Q+ +
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
Query: 588 HDRNKEVEDLSATLLCKLGPGQSEIAEE-------LCQRLQRKERMLQDLLS---DRNKQ 637
K++ D A L +L E++++ + + Q + D +S K+
Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
Query: 638 VLEHEMEI--QGLLQSVSTREQESQAAAEKLVQA----LMERNSELQALRQYL---GGRD 688
+E E+ + L +S E++ AE+L + L E+ E+ L+Q + G
Sbjct: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
Query: 689 SLMSQAPISNQQAEV---TPTGCLGKQTDQGSMQIPS-RDDSTSLTA---KEDVSIPRST 741
M++ ++ V T L +Q Q S + S D T L A K +V + +S
Sbjct: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 742 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
KE + +E+L + E + ++S L S + +EE Q + E
Sbjct: 1148 -----------KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
Query: 802 RNIQIKEDLIKDLQMQLVDPEDI------PAMERLTQEVLLLREK----VASVESQGQEI 851
++++ K K L +L DI +E T E++ + + S S Q
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256
Query: 852 SGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVK-FHAHPESSERDRTLQVELEGA 910
+ ++ LL+ + + ++L + + + L S + H E + ++++ ++E
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316
Query: 911 QVLRSRLEEVLGRSLERLNRLET 933
+ L++ G + + E+
Sbjct: 1317 VTEKEALQKEGGNQQQAASEKES 1339
Score = 97.8 bits (242), Expect = 4e-20
Identities = 133/610 (21%), Positives = 276/610 (45%), Gaps = 77/610 (12%)
Query: 18 ENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVE 77
E+ L ++ +E ++K +E ++ + L+ +V S+K EL+ KK+ L+ V+
Sbjct: 1558 EHKELVQKLQHFQELGEEKDNRVKE-AEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616
Query: 78 N-------LNSQNEAELRRQFEERQQETEHVYELLENKI--QLLQEESRLAKNEAARMA- 127
+ L + E+E + E +++ E ++ ++ Q+ ++E + K + ++
Sbjct: 1617 SKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSE 1676
Query: 128 ---ALVEAEKECNLELSEKLKGVTKNWED---VPGDQVKPDQYTE-------ALAQR--D 172
L E E+E ++ L EKLK V + + VP YTE Q+ +
Sbjct: 1677 LNTKLQEREREVHI-LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE 1735
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
++I L ++L +E+L++++ +EK EE S + + Q++L E
Sbjct: 1736 EKISVLQRNLTEKEKLLQRVGQEK-------EETVSSHFEMRCQ---YQERLIKLEHAEA 1785
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q S + LQE++++ ++ + E K ++ Q + ++++TL+
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG-KNNIQAKQNLENVFDDVQKTLQE 1844
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+E + L Q I+ + + + +E +H+ ++ +L S A QQ+ + + L
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKE-VHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN 1903
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
E + +V+ K +A+ + A E E+QK K L+K L+ L++E Q
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG--KEIVRLQKDLRMLRKEHQ 1961
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L+ ++ E QEQ L H+ S +QL++EF L ++ + EM
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHN-STLKQLMREFNTQLAQKE------QELEM 2014
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 532
+++ + +A + + LE ++E QL + E+D DL+R
Sbjct: 2015 TIKE----------TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR---------- 2054
Query: 533 TMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES------IIQQLQTS 586
T + E +L A+ E+++ ++LQ EE++ K+ + +++E+ I +LQT
Sbjct: 2055 TAKRYEEILDAR---EEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQ 2111
Query: 587 LHDRNKEVED 596
L + + D
Sbjct: 2112 LAQKTTLISD 2121
Score = 90.9 bits (224), Expect = 5e-18
Identities = 163/829 (19%), Positives = 335/829 (40%), Gaps = 133/829 (16%)
Query: 172 DKRIEEL--NQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHET 229
D E+L N +E+L+++L R ++ L + + + ++L+++K
Sbjct: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT---AYQMLQREKKKLQGI 177
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLN-------------------------- 263
Q S +AEL+E++Q + K LQE+ +
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 264 --------------EMSYELKCAQESSQK------QDGTIQNLKETLKSRERETEELY-- 301
E E+ +E+ + +DGT ETL+ R + E L
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
Query: 302 --QVIEGQNDTMAKL---REMLHQ---------SQLGQLHSSEGTS------PAQQQVAL 341
+ I+ + L +E L + ++ LH +E T A+ +
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 342 LDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN-QEL 400
L+ + ++ + +++ + KE ++A + ++ + E +QKE S + +EL
Sbjct: 358 LEQDKGMVIAETK-RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK-EQLLQEFRELLQY 459
KAL Q+ + R +AE +I+T E+ + SL + ++ QE ++++
Sbjct: 417 EKALSTAQK----TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK 472
Query: 460 RDNSD--KTLEANEMLLEKLRQRIHDKAVALERAIDEKFS-ALEEKEKELRQLRLAVRER 516
K + +E L + Q + K ER E+ ALE+ + E L+++ +
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSE--YLKISQEKE 530
Query: 517 DHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 576
+ L ++ +A + E+ LR E E T + L+ +E + +
Sbjct: 531 QQESLALEELELQKKAILTESENKLRDLQQEAETYRT---RILELESSLEKSLQENKNQS 587
Query: 577 ESIIQQLQTSLHDRNKEVE---DLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ + L+ + NKE+ + T L L Q + E Q L+++ + + L +
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+ +Q E ++ + ++ E+ ++ EKL E S L + L R L +
Sbjct: 648 KCEQEKETLLKDKEIIFQAHI-EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 694 APISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEK 753
+ Q + K +Q + D S+ + +VSI R+ EK
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVD---SIIKEHEVSIQRT-----------EK 752
Query: 754 ELSNAKEELELMAKKE----RESQMELSALQSMMAVQEEELQVQAADME-------SLTR 802
L + +LEL+ K+ +E Q + L++ + E ELQ +A ++ +
Sbjct: 753 ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 803 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGN---RRQQL 859
+ E+ + LQ +L+D L E +LL ++VA VE+Q +++ + Q+
Sbjct: 813 QTKAYEEQLAQLQQKLLD---------LETERILLTKQVAEVEAQKKDVCTELDAHKIQV 863
Query: 860 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELE 908
+++ L + S + + +++ Q+Y S ++ + E+++T Q+ +E
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLE----DGNKEQEQTKQILVE 908
Score = 82.8 bits (203), Expect = 1e-15
Identities = 147/731 (20%), Positives = 306/731 (41%), Gaps = 95/731 (12%)
Query: 9 SQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQH 68
+QH N +K+ L+L+ E+ +Q +E++ ++N + LK E++D K
Sbjct: 1454 TQHQNTVKELQIQLELKSKEAYEKDEQ-INLLKEELDQQNKRF----DCLKGEMEDDKSK 1508
Query: 69 LDKTWADVEN-LNSQNEA--ELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
++K +++E L SQ EL ++ E E + E+L+N Q E + +
Sbjct: 1509 MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
L E + E EK+ + + + L + K +E +N S+ ++
Sbjct: 1569 FQELGEEKDNRVKEAEEKILTLENQVYSMKAE----------LETKKKELEHVNLSVKSK 1618
Query: 186 ER----LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHL 241
E L ++L E L L+ ++ + ++LL Q + + + ++SHL
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ----YKKGTESHL 1674
Query: 242 AELQEKIQQTEATNKILQEKLNEM----SYELKCAQESSQKQDGTIQNLKETLKSRERET 297
+EL K+Q+ E IL+EKL + S L + + T Q ++ ++
Sbjct: 1675 SELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734
Query: 298 EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK 357
EE V++ KL + + Q + + SS Q Q L+ L+ A + + +
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHA----EAKQHE 1789
Query: 358 LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQ 417
Q ++ + +L + + + A E E K+N + ++ L+ + +++Q Q
Sbjct: 1790 DQSMIGHLQEELEEKNKKYSLIVAQHVEKE-----GGKNNIQAKQNLENVFDDVQKTLQ- 1843
Query: 418 LRAWEAEKYNEIRTQEQNIQHLNHSLSHK--------EQLLQEFREL--LQYRDNSDKTL 467
EK + EQ I+ L+ L + E+L ++ +L LQ D +K
Sbjct: 1844 ------EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897
Query: 468 EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEK----EKELRQLRLAVRERDHDLERL 523
E E E+ + + H L ++ + + LE K E+E ++L + DL L
Sbjct: 1898 ELLEENTEE-KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 524 RDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQL 583
R + Q +E L + E E+ ++ +E++E K + K+ ++++
Sbjct: 1957 R------KEHQQELEILKKEYDQEREE------KIKQEQEDLELKHNSTLKQ---LMREF 2001
Query: 584 QTSLHDRNKEVE-----------DLSATLLCKLGPGQSEIAEELCQR---LQRKERMLQD 629
T L + +E+E ++ A LL +++ +++ ++ L+R + ++
Sbjct: 2002 NTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 630 LLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDS 689
+L R +++ ++Q L+ + + Q+ E N + L+ L + +
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN----PGNDNVTIMELQTQLAQKTT 2117
Query: 690 LMSQAPISNQQ 700
L+S + + Q+
Sbjct: 2118 LISDSKLKEQE 2128
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/328 (21%), Positives = 138/328 (42%), Gaps = 55/328 (16%)
Query: 14 DLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 73
+L +EN K + + ++ ++ EA D L+ ++ +RE Q + + +
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHND-------LEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 74 ADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARM------A 127
D+ L +++ EL +E QE E KI+ QE+ L N +
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQEREE-------KIKQEQEDLELKHNSTLKQLMREFNT 2003
Query: 128 ALVEAEKECNLELSEKL-KGVTKNWEDVPGDQVKPDQYTEALAQRD-------KRIEEL- 178
L + E+E + + E + K E + Q + +Q + +A++D KR EE+
Sbjct: 2004 QLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEIL 2063
Query: 179 ---NQSLAAQER----LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTI 231
+ + A+ R +E+L ++ QQ L E P + V +++ Q + +TT+
Sbjct: 2064 DAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV-----TIMELQTQLAQKTTL 2118
Query: 232 TQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLK 291
+SDS L E QE +Q L+++L + + + + G + + +L
Sbjct: 2119 ----ISDSKLKE-QEFREQIHN----LEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLF 2169
Query: 292 SRERETEELYQVI-----EGQNDTMAKL 314
E E L +V+ + TMAK+
Sbjct: 2170 GEPTEFEYLRKVLFEYMMGRETKTMAKV 2197
Score = 46.6 bits (109), Expect = 1e-04
Identities = 50/223 (22%), Positives = 94/223 (42%), Gaps = 33/223 (14%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDI-YKRNIELKVEVESLKRELQDKKQH 68
Q L LKKE ++ ++K + +ED+ K N LK + +L K+Q
Sbjct: 1962 QELEILKKE----------YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011
Query: 69 LDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAA 128
L+ T + N + EAEL E Q+ET + ++ + E+ K A R
Sbjct: 2012 LEMTIKETINKAQEVEAEL---LESHQEETNQL-------LKKIAEKDDDLKRTAKRYEE 2061
Query: 129 LVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL 188
+++A +E E++ K++ + E++ + + E + I EL LA + L
Sbjct: 2062 ILDAREE---EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTL 2118
Query: 189 VEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTI 231
+ ++Q+ + E+ LK+ + N + TT+
Sbjct: 2119 ISDSKLKEQEFREQIHN---------LEDRLKKYEKNVYATTV 2152
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 131 bits (330), Expect = 3e-30
Identities = 215/1025 (20%), Positives = 436/1025 (42%), Gaps = 145/1025 (14%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKR---NIELKVEVES 57
+L Q NDL+ + + + + EER Q + EA +++ +R E+ E+ +
Sbjct: 881 SLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA 940
Query: 58 LKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESR 117
KR+L+D+ L K D+E ++ E E +H ENK++ L EE
Sbjct: 941 KKRKLEDECSELKKDIDDLELTLAKVEKE------------KHA---TENKVKNLTEE-- 983
Query: 118 LAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE 177
MA L E + E + + +D+ ++ K + +++ + ++++++
Sbjct: 984 --------MAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDD 1035
Query: 178 LNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQS-- 235
L SL ++++ L R K++L L+ + ++L ++KL E I QQ+
Sbjct: 1036 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSK 1095
Query: 236 VSDSHL--AELQEKIQQTEATNKILQEKL--------------NEMSYELKCAQESSQKQ 279
+ D + +LQ+K+++ +A + L+E+L +++S EL+ E ++
Sbjct: 1096 IEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1155
Query: 280 DGTIQNLKETLKSRERETEELYQVIEG---QNDTMAKLREMLHQSQLGQLHSSEGTSPAQ 336
G E K RE E +++ + +E Q++ A H + +L E Q
Sbjct: 1156 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL--GEQIDNLQ 1213
Query: 337 QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 396
+ L+ + + F +LE+ + + Q + A+ ++ + +E A+E + E + +
Sbjct: 1214 RVKQKLEKEKSEF--KLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Query: 397 NQELRKALQQLQEELQNKSQQLRAWEA-------------EKYNEIRTQEQNIQHLNHSL 443
+ +LQ E ++QL EA ++ +++ Q + ++L
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNAL 1331
Query: 444 SHKEQLLQEFRELL--QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
+H Q + +LL QY + ++ E + +L K + E ++ LEE
Sbjct: 1332 AHALQSARHDCDLLREQYEEETEAKAEL-QRVLSKANSEVAQWRTKYETDAIQRTEELEE 1390
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
+K+L Q +++ + +E + SS E T +++ + ++VE+ + L
Sbjct: 1391 AKKKLAQ---RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447
Query: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
+ + + W+++ E + Q+ L KE LS T L KL E E L + +
Sbjct: 1448 QRNFDKILAEWKQKYE----ESQSELESSQKEARSLS-TELFKLKNAYEESLEHL-ETFK 1501
Query: 622 RKERMLQDLLSDRNKQVLE---HEMEIQGLLQSVSTREQESQAAAE-----------KLV 667
R+ + LQ+ +SD +Q+ E + E++ + + + + E Q+A E K++
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
Query: 668 QALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+A +E N + + L +D M QA ++Q+ + Q S+ +R +
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV---------VDSLQTSLDAETRSRNE 1612
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQE 787
L K+ + GDL+ +E +LS+A + E+Q ++ +LQS++ +
Sbjct: 1613 VLRVKKKME------GDLNE---MEIQLSHAN-------RMAAEAQKQVKSLQSLLKDTQ 1656
Query: 788 EELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLT--------QEVLLLRE 839
+L + L NI I E LQ +L E++ A+ T QE++ E
Sbjct: 1657 IQLDDAVRANDDLKENIAIVERRNNLLQAEL---EELRAVVEQTERSRKLAEQELIETSE 1713
Query: 840 KVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQ----AERQLYSSLVKFHAHPE 895
+V + SQ + +++ M L +S + EA+Q AE + ++ E
Sbjct: 1714 RVQLLHSQNTSLINQKKK----MESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAE 1769
Query: 896 SSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTD 955
++++ LE ++ +E+ + RL+ E +A GG E E
Sbjct: 1770 ELKKEQDTSAHLER---MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEG 1826
Query: 956 SIEEE 960
+E E
Sbjct: 1827 ELEAE 1831
Score = 116 bits (290), Expect = 1e-25
Identities = 178/929 (19%), Positives = 400/929 (43%), Gaps = 151/929 (16%)
Query: 12 LNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDK 71
+N L K L+ ++ LE ++Q+ + +++++E KR+L+ + +
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKK------------VRMDLERAKRKLEGDLKLTQE 1066
Query: 72 TWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQEESRLAKNEAA--RMAA 128
+ D+EN Q E +L++ +F+ QQ ++ + + ++ LQ + +L +N+A +
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSK----IEDEQVLALQLQKKLKENQARIEELEE 1122
Query: 129 LVEAEKECNL-------ELSEKLKGVTKNWEDVPGD---QVKPDQYTEALAQRDKR---- 174
+EAE+ +LS +L+ +++ E+ G Q++ ++ EA Q+ +R
Sbjct: 1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 175 -------------------IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTS------- 208
+ EL + + +R+ ++L +EK + L++ TS
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242
Query: 209 -----------MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKI 257
+E Q + ++ S TQ++ + EL ++++ EA I
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL--I 1300
Query: 258 LQEKLNEMSYELKCAQESSQ-KQDGTIQN-LKETLKSRERETEELYQVIEGQNDTMAKLR 315
Q ++SY + Q +++G +N L L+S + + L + E + + A+L+
Sbjct: 1301 SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360
Query: 316 EMLHQ--SQLGQ---------LHSSEGTSPAQQQVA--LLDLQSALFCSQLEIQKLQRVV 362
+L + S++ Q + +E A++++A L D + A+ + L++
Sbjct: 1361 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE 422
+ + ++ D V+ AAA ++++ K E ++ ++ Q EL++ ++ R+
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1480
Query: 423 AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH 482
E + E++++HL + L +E +L + K + LEK+R+++
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE----LEKVRKQLE 1536
Query: 483 DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER--------LRDVLSSNEATM 534
+ + L+ A++E ++LE +E ++ + +L + ++ER + +++ +
Sbjct: 1537 VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVV 1596
Query: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS---RWQKEQESIIQQLQTSLHDRN 591
S+++ L A+ ++ + ++ EME + S R E + ++ LQ+ L D
Sbjct: 1597 DSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656
Query: 592 KEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS 651
+++D ++ E + + +R +L+ E+E L++
Sbjct: 1657 IQLDDAVR--------ANDDLKENIA-------------IVERRNNLLQAELE---ELRA 1692
Query: 652 VSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK 711
V + + S+ AE Q L+E + +Q L SL++Q ++++T L
Sbjct: 1693 VVEQTERSRKLAE---QELIETSERVQLLHSQ---NTSLINQK--KKMESDLTQ---LQS 1741
Query: 712 QTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE----------KELSNAKEE 761
+ ++ + + ++ + + + DT A LE K+L + +E
Sbjct: 1742 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
Query: 762 LELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP 821
E +A K + Q L L++ + E EL+ + + ++ E IK+L Q
Sbjct: 1802 AEQIALKGGKKQ--LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQ--TE 1857
Query: 822 EDIPAMERLTQEVLLLREKVASVESQGQE 850
ED + RL V L+ KV + + Q +E
Sbjct: 1858 EDKKNLLRLQDLVDKLQLKVKAYKRQAEE 1886
Score = 95.9 bits (237), Expect = 2e-19
Identities = 143/698 (20%), Positives = 292/698 (41%), Gaps = 102/698 (14%)
Query: 2 SNGYRT----LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVES 57
+N YR + LND + L+ L ++++K EA + + + ++E
Sbjct: 1258 ANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK-EALISQLTRGKLSYTQQMED 1316
Query: 58 LKRELQD----------------------KKQHLDKTWADVEN---LNSQNE--AELRRQ 90
LKR+L++ ++Q+ ++T A E L+ N A+ R +
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1376
Query: 91 FE-ERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTK 149
+E + Q TE + E + Q LQ+ + A+ ++L + + E+ + + V +
Sbjct: 1377 YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1436
Query: 150 NWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSM 209
+ K + + LA+ ++ EE L + ++ LS E +L + EE
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496
Query: 210 -------------EVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEAT-- 254
E+ +TE+L + K N HE ++ + L ELQ +++ EA+
Sbjct: 1497 LETFKRENKNLQEEISDLTEQLGEGGK-NVHELEKVRKQLEVEKL-ELQSALEEAEASLE 1554
Query: 255 -------------NKI---LQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETE 298
N+I ++ KL E E++ A+ + Q+ + +L+ +L + R
Sbjct: 1555 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQR---VVDSLQTSLDAETRSRN 1611
Query: 299 ELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKL 358
E+ +V + K+ L++ ++ H++ + AQ+QV LQS L +Q+++
Sbjct: 1612 EVLRVKK-------KMEGDLNEMEIQLSHANRMAAEAQKQVK--SLQSLLKDTQIQLDDA 1662
Query: 359 QRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL 418
R + +A ++ ++A E E + + RK +Q E + Q L
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQT----ERSRKLAEQELIETSERVQLL 1718
Query: 419 RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNS--DKTLEANEML--- 473
+ N+ + E ++ L S E+ +QE R + + D + A E+
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQ---SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1775
Query: 474 -----LEKLRQRIHDKAVALERAIDEKFS-ALEEKEKELRQLRLAVRERDHDLERLRDVL 527
LE++++ + L+ +DE AL+ +K+L++L VRE + +LE +
Sbjct: 1776 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRN 1835
Query: 528 SSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587
+ + M+ E ++ + E+ LQ L ++++ K ++++ E +Q T+L
Sbjct: 1836 AESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1895
Query: 588 HDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKER 625
K +L +++IAE +L+ K R
Sbjct: 1896 SKFRKVQHELDE------AEERADIAESQVNKLRAKSR 1927
Score = 84.3 bits (207), Expect = 5e-16
Identities = 101/495 (20%), Positives = 217/495 (43%), Gaps = 64/495 (12%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y +HL K+EN +L+ I L E++ + + E R+ + +EL+
Sbjct: 1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + + + ++ E +L + EE +Q + ++++ L
Sbjct: 1546 LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDA 1605
Query: 115 ESRLAKNEAARMAALVEAE-KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
E+R ++NE R+ +E + E ++LS + + + V Q L +
Sbjct: 1606 ETR-SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1664
Query: 174 RIEELNQSLAAQERLVEQLSREKQQLLHLLEE---PTSMEVQPMTEELLKQQKLNSHETT 230
++L +++A ER L E ++L ++E+ + Q + E + Q L+S T+
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1724
Query: 231 -ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
I Q+ +S L +LQ +++ E E + A+E ++K + E
Sbjct: 1725 LINQKKKMESDLTQLQSEVE--------------EAVQECRNAEEKAKKAITDAAMMAEE 1770
Query: 290 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALF 349
LK + + L ++ + T+ L+ L +++ Q AL
Sbjct: 1771 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE----------------------QIALK 1808
Query: 350 CSQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 408
+ ++QKL+ VR+ E +L A+ K+ + V+ + KE +++ +E +K L +LQ
Sbjct: 1809 GGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQ-TEEDKKNLLRLQ 1867
Query: 409 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE 468
+ + +++A++ R E+ + N +LS +FR++ D +++ +
Sbjct: 1868 DLVDKLQLKVKAYK-------RQAEEAEEQANTNLS-------KFRKVQHELDEAEERAD 1913
Query: 469 ANEMLLEKLRQRIHD 483
E + KLR + D
Sbjct: 1914 IAESQVNKLRAKSRD 1928
Score = 82.0 bits (201), Expect = 2e-15
Identities = 133/734 (18%), Positives = 297/734 (40%), Gaps = 48/734 (6%)
Query: 259 QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML 318
++++ M E +E+ +K + + L+E + S +E +L ++ + D + E
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907
Query: 319 HQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQF 378
Q ++ Q + + ++ L + +L R+ E + ++ K+ +
Sbjct: 908 DQLIKNKI---------QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDD 958
Query: 379 VEAAAHESEQQKEASWKHNQELRKALQQLQE---ELQNKSQQLRAWEAEKYNEIRTQEQN 435
+E + E++K A+ + L + + L E +L + + L+ + ++++ +E
Sbjct: 959 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018
Query: 436 IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEK 495
+ L+ S EQ + + L+ LE + LE + + + LE +
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQL 1078
Query: 496 FSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK---GLEVEQL- 551
L++KE ++ Q + + +L+ L N+A ++ +E L A+ +VE+L
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138
Query: 552 STTCQNLQWLKEEMETKFS------RWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 605
S + L+ + E +E K++E+ Q+++ L + + E +A L K
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198
Query: 606 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 665
+E+ E++ LQR ++ L+ S+ ++ + ++ ++++ + E+ S+ ++
Sbjct: 1199 ADSVAELGEQI-DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQ 1257
Query: 666 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDD 725
+ ++ ++L + R L ++ +Q E L Q +G + + +
Sbjct: 1258 ANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE--EKEALISQLTRGKLSYTQQME 1315
Query: 726 STSLTAKED-------VSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSA 778
+E+ +S D D + +E + AK EL+ + K +
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375
Query: 779 LQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLR 838
A+Q E +A + L + +Q E+ ++ + + E RL E+ L
Sbjct: 1376 KYETDAIQRTEELEEA--KKKLAQRLQDAEEAVEAVNAKCSSLE--KTKHRLQNEIEDLM 1431
Query: 839 EKVASVESQGQEISGNRRQQLLLMLE---GLVDERSRLNEALQAERQLYSSLVKF-HAHP 894
V + + +R ++ E + +S L + + R L + L K +A+
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 895 ESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFT 954
ES E T + E + Q S L E LG + ++ LE + E E
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR--------KQLEVEKLELQ 1543
Query: 955 DSIEEEAAHHSHQQ 968
++EE A H++
Sbjct: 1544 SALEEAEASLEHEE 1557
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 131 bits (329), Expect = 3e-30
Identities = 201/1011 (19%), Positives = 424/1011 (41%), Gaps = 117/1011 (11%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKK 66
TL Q NDL+ L+ + + A E+ + I+ K+++E+ +E+ ++
Sbjct: 883 TLMQEKNDLQ------------LQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERA 930
Query: 67 QHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARM 126
+ D E +N++ A+ +R+ E+ E + + LE + +++E +N+ +
Sbjct: 931 E-------DEEEINAELTAK-KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 982
Query: 127 AALVEAEKECNLELSEKLKGVTK----NWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
+ E +L+++ K + + +D+ ++ K + T+A + ++++++L SL
Sbjct: 983 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1042
Query: 183 AAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSD- 238
++++ L R K++L L L +E T M+++ ++L ++ K E + Q + D
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQEST-MDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101
Query: 239 ---------------SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTI 283
+ + EL+E+I+ A+ +++ +++S EL+ E ++ G
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Query: 284 QNLKETLKSRERETEELYQVIEGQN---------------DTMAKLREMLHQSQLGQLHS 328
E K RE E +++ + +E D++A+L E + Q ++
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ--RVKQ 1219
Query: 329 SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ 388
++ ++ + DL S + L+++ R E QL++ K + + ++
Sbjct: 1220 KLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTA 1279
Query: 389 QKEASWKHNQELRKALQ-------QLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
Q+ + E + L QL Q +QQ+ + + EI+ + + H
Sbjct: 1280 QRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSA-LAHALQ 1338
Query: 442 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
S H LL+E QY + + E + + K + E ++ LEE
Sbjct: 1339 SSRHDCDLLRE-----QYEEEQEAKAEL-QRAMSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
+K+L Q +++ + +E + +S E T Q +++ + ++VE+ + C L
Sbjct: 1393 AKKKLAQ---RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK 1449
Query: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
+ + + W+++ E +L+ S KE LS T L K+ E ++L + L+
Sbjct: 1450 QRNFDKILAEWKQKCEETHAELEAS----QKESRSLS-TELFKIKNAYEESLDQL-ETLK 1503
Query: 622 RKERMLQDLLSDRNKQVLE-----HEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSE 676
R+ + LQ +SD +Q+ E HE+E + + V + E QAA E+ +L +
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIHELE--KIKKQVEQEKSELQAALEEAEASLEHEEGK 1561
Query: 677 LQA----LRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK 732
+ L Q D +++ Q + + +I SR+D+ L K
Sbjct: 1562 ILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1621
Query: 733 EDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMM---AVQEEE 789
+ GDL+ +E +L++A + R +Q L Q + +E+
Sbjct: 1622 ME--------GDLNE---MEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQED 1670
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQ 849
L+ Q A +E +Q + I++L+ L E + + QE+L E+V + +Q
Sbjct: 1671 LKEQLAMVERRANLLQAE---IEELRATLEQTER--SRKIAEQELLDASERVQLLHTQNT 1725
Query: 850 EISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG 909
+ +++ + + + + EA AE + ++ E ++++ LE
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 910 AQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
++ LE+ + RL+ E LA GG E E +E E
Sbjct: 1786 ---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE 1833
Score = 121 bits (303), Expect = 4e-27
Identities = 210/967 (21%), Positives = 417/967 (43%), Gaps = 149/967 (15%)
Query: 24 LRIYF-----LEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVEN 78
+++YF L+ +K A+ ++ +++ E + E+ ++EL++K L + D++
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ- 892
Query: 79 LNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL 138
L Q EA+ EER + L++ KIQL E+++ + + E E+E N
Sbjct: 893 LQVQAEADSLADAEERCDQ------LIKTKIQL---EAKIKE-----VTERAEDEEEINA 938
Query: 139 ELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK-----RIEELNQSLAAQERLVEQLS 193
EL+ K + + ++ D + + T A +++K +++ L + +A + + +L+
Sbjct: 939 ELTAKKRKLEDECSELKKD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 997
Query: 194 REKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVS-DSHLAELQEKIQQTE 252
+EK+ L + Q + + ++ K+N T+T+ + + + +L+ ++Q +
Sbjct: 998 KEKKALQEAHQ-------QTLDDLQAEEDKVN----TLTKAKIKLEQQVDDLEGSLEQEK 1046
Query: 253 ATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMA 312
L+ ++ +LK AQES+ + Q L E LK +E E L IE +
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM 1106
Query: 313 KLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQ--LA 370
+L++ + + Q ++ E ++E ++ R +K+R
Sbjct: 1107 QLQKKIKELQ-ARIEELE--------------------EEIEAERASRAKAEKQRSDLSR 1145
Query: 371 DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE-ELQNK--SQQLRAWEAEKYN 427
+ ++ + +E A + Q E + K E +K + L+E LQ++ + LR A+
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 428 EIRTQEQNIQHLNHSL-SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAV 486
E+ Q N+Q + L K ++ E +L ++ +T+ + LEK+
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA----SNMETVSKAKGNLEKMC-------- 1253
Query: 487 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGL 546
RA++++ S ++ KE+E ++L D +R R S E + Q L K
Sbjct: 1254 ---RALEDQLSEIKTKEEEQQRL-----INDLTAQRARLQTESGEYSRQ-----LDEKDT 1300
Query: 547 EVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD------RNKEVEDLSAT 600
V QLS Q EE++ + K + ++ LQ+S HD + +E ++ A
Sbjct: 1301 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 601 LLCKLGPGQSEIAE-------ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVS 653
L + SE+A+ + QR + E + L+ R + EH + S+
Sbjct: 1361 LQRAMSKANSEVAQWRTKYETDAIQRTEELEE-AKKKLAQRLQDAEEHVEAVNAKCASLE 1419
Query: 654 TREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQT 713
+Q Q E L+ + N+ AL + D ++++ Q+ E T
Sbjct: 1420 KTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAE---WKQKCEET-------HA 1469
Query: 714 DQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQ 773
+ + Q SR ST L I + LD + L++E N ++E+ + ++ E
Sbjct: 1470 ELEASQKESRSLSTEL-----FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1524
Query: 774 MELSALQSM-MAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQL------VDPEDIPA 826
+ L+ + V++E+ ++QAA +E +++ +E I +Q++L VD +
Sbjct: 1525 KRIHELEKIKKQVEQEKSELQAA-LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1583
Query: 827 MERLTQEVLLLREKVASVESQGQEI-----SGNRRQQLLLMLEGLVDERS-RLN------ 874
E + Q + R + VES + S N +L +EG ++E +LN
Sbjct: 1584 DEEIDQ---MKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1640
Query: 875 -EALQAERQLYSSLVKFHAHPESSERDR-----TLQVELEGAQVLRSRLEEVLGRSLERL 928
EAL+ R + L H + + R + L + A +L++ +EE L +LE+
Sbjct: 1641 AEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEE-LRATLEQT 1699
Query: 929 NRLETLA 935
R +A
Sbjct: 1700 ERSRKIA 1706
Score = 116 bits (291), Expect = 9e-26
Identities = 201/991 (20%), Positives = 420/991 (42%), Gaps = 138/991 (13%)
Query: 3 NGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYE--ASRED----IYKRNIELKVEVE 56
N + L++ + L + L L+E QQ + + ED + K I+L+ +V+
Sbjct: 977 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1036
Query: 57 SLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEES 116
L+ L+ +K K D+E + E +L+ E +EN Q L E+
Sbjct: 1037 DLEGSLEQEK----KIRMDLERAKRKLEGDLKLAQESTMD--------IENDKQQLDEKL 1084
Query: 117 RLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIE 176
+ + E + + + +E E+ ++L +K+K + E++ ++++ ++ + A A++ +
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE-EEIEAERASRAKAEKQR--S 1141
Query: 177 ELNQSLAA-QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQS 235
+L++ L ERL E Q+ + + E Q M +L ++ L T T +
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQKMRRDL-EEATLQHEATAATLRK 1198
Query: 236 VSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 295
+AEL E+I + + L+++ +EM E+ + + NL++ ++ E
Sbjct: 1199 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE- 1257
Query: 296 ETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEI 355
++L ++ + + + ++ Q Q S E + ++ L+ S Q
Sbjct: 1258 --DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR--GKQAFT 1313
Query: 356 QKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKS 415
Q+++ + RQ E ++ ++++ H+ + +E +E ++A +LQ + +
Sbjct: 1314 QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE----QYEEEQEAKAELQRAMSKAN 1369
Query: 416 QQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNS-DKTLEANEMLL 474
++ W + + + + ++ L+ + Q +E E + + S +KT + + +
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 475 EKL----------------RQRIHDKAVA-LERAIDEKFSALEEKEKELRQLRLAVRERD 517
E L +QR DK +A ++ +E + LE +KE R L
Sbjct: 1430 EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLST------ 1483
Query: 518 HDLERLRDVLSSNEATMQSMESLLRA-KGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 576
L + ++ E ++ +E+L R K L+ E T Q + K E + + Q EQ
Sbjct: 1484 ----ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1539
Query: 577 ESIIQQLQTSLHDRNKEVEDLSATLL---CKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
E +LQ +L + +E +L +L +SE+ ++ ++ + ++M ++ +
Sbjct: 1540 EK--SELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRI 1597
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGR------ 687
+ EI+ ++ +++ E +Q +ALR Y +
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657
Query: 688 -----DSLMSQAPISNQ-----------QAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTA 731
D+L SQ + Q QAE+ +QT++ S +I ++ L A
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER-SRKIAEQE---LLDA 1713
Query: 732 KEDVSIPRSTLGDL-DTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEEL 790
E V + + L +T LE ++S + E+E + ++ R ++ + + A+ EEL
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773
Query: 791 QVQ---AADMESLTRNIQIKEDLIKDLQMQLVDPEDI------PAMERLTQEVLLLREKV 841
+ + +A +E + +N+ E +KDLQ +L + E + +++L V L +V
Sbjct: 1774 KKEQDTSAHLERMKKNL---EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1830
Query: 842 ASVESQGQE-ISGNRRQQL---------------LLMLEGLVDE-----RSRLNEALQAE 880
S + + E + G R+ + +L L+ LVD+ +S +A +AE
Sbjct: 1831 ESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890
Query: 881 RQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911
Q +L KF R +Q ELE A+
Sbjct: 1891 EQSNVNLSKF----------RRIQHELEEAE 1911
Score = 83.6 bits (205), Expect = 8e-16
Identities = 151/774 (19%), Positives = 309/774 (39%), Gaps = 145/774 (18%)
Query: 286 LKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ 345
+K LKS E E E MA ++E +++ A+ + +L+
Sbjct: 840 IKPLLKSAETEKE------------MANMKEEFEKTK---------EELAKTEAKRKELE 878
Query: 346 SALFCSQLEIQKLQRVVRQKERQLADAKQ-CVQFV------EAAAHESEQQKEASWKHNQ 398
+ E LQ V+ + LADA++ C Q + EA E ++ E + N
Sbjct: 879 EKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA 938
Query: 399 ELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-R 454
EL ++L++E L+ L A+ E E +++L ++ ++ + + +
Sbjct: 939 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 998
Query: 455 ELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVR 514
E ++ +TL+ + +K+ K + LE+ +D+ +LE+++K L A R
Sbjct: 999 EKKALQEAHQQTLDDLQAEEDKVNTLTKAK-IKLEQQVDDLEGSLEQEKKIRMDLERAKR 1057
Query: 515 ERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ- 573
+ + DL+ ++ E Q ++ L+ K E+ L + ++ Q L +++ K Q
Sbjct: 1058 KLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA 1117
Query: 574 ---------------------------------------------------KEQESIIQQ 582
K++E+ Q+
Sbjct: 1118 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1177
Query: 583 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHE 642
++ L + + E +ATL K +E+ E++ LQR ++ L+ K+ E +
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKHADSVAELGEQI-DNLQRVKQKLE-------KEKSEMK 1229
Query: 643 MEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE 702
MEI L ++ T +++ EK+ +AL ++ SE++ + + L++ ++ Q+A
Sbjct: 1230 MEIDDLASNMET-VSKAKGNLEKMCRALEDQLSEIKTKEE---EQQRLIND--LTAQRAR 1283
Query: 703 V-TPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEE 761
+ T +G +Q D+ + ++ + R ++ + L L +++ +
Sbjct: 1284 LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHD 1343
Query: 762 LELMAKKERESQMELSALQSMMAVQEEELQVQAADMES-LTRNIQIKEDLIKDLQMQLVD 820
+L+ ++ E Q + LQ M+ E+ E+ + + E+ K L +L D
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 821 PEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLE------GLVDERSRLN 874
E + V + K AS+E Q + N + L++ +E +D++ R
Sbjct: 1404 AE---------EHVEAVNAKCASLEKTKQRLQ-NEVEDLMIDVERTNAACAALDKKQRNF 1453
Query: 875 EALQAE-------------------RQLYSSLVKF-HAHPESSERDRTLQVELEGAQVLR 914
+ + AE R L + L K +A+ ES ++ TL+ E + Q
Sbjct: 1454 DKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEI 1513
Query: 915 SRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQ 968
S L E + +R++ LE + E +E ++EE A H++
Sbjct: 1514 SDLTEQIAEGGKRIHELEKIK--------KQVEQEKSELQAALEEAEASLEHEE 1559
Score = 74.3 bits (181), Expect = 5e-13
Identities = 99/506 (19%), Positives = 226/506 (44%), Gaps = 71/506 (14%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L LK+EN +L+ I L E++ + + E ++ + + EL+
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE Q + ++E+ L
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA 1607
Query: 115 ESRLAKNEAARMAALVEAE-KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
E R ++N+A R+ +E + E ++L+ + + + ++ + T+A+ +D
Sbjct: 1608 EIR-SRNDAIRLKKKMEGDLNEMEIQLNHANR--------MAAEALRNYRNTQAIL-KDT 1657
Query: 174 RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQ 233
++ L+ +L +QE L EQL+ +++ +LL+ E++ E+ + +K+ E
Sbjct: 1658 QL-HLDDALRSQEDLKEQLAMVERR-ANLLQAEIE-ELRATLEQTERSRKIAEQELLDAS 1714
Query: 234 QSVSDSHL--AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLK 291
+ V H L ++ E +Q ++ ++ E + A+E ++K + E LK
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 292 SRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS 351
+ + L ++ + T+ L+ L +++ Q AL
Sbjct: 1775 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAE----------------------QLALKGG 1812
Query: 352 QLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRK--ALQQLQ 408
+ +IQKL+ VR+ E ++ ++ K+ V+ V+ + KE +++ ++ + LQ L
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLV 1872
Query: 409 EELQN--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
++LQ KS + +A EAE+ + + L +FR + + +++
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSNVN-------------------LSKFRRIQHELEEAEER 1913
Query: 467 LEANEMLLEKLR---QRIHDKAVALE 489
+ E + KLR + +H K ++ E
Sbjct: 1914 ADIAESQVNKLRVKSREVHTKIISEE 1939
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 130 bits (327), Expect = 6e-30
Identities = 204/874 (23%), Positives = 366/874 (41%), Gaps = 133/874 (15%)
Query: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKI 109
EL +VE L+R+L ++ + K ++ L RQ EE+ +E + ELLE +
Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKL--------EPSQVGLERQLEEKTEECSRLQELLERR- 413
Query: 110 QLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALA 169
+ E++ + E M L++ ++ L ++ + + V G + + + L
Sbjct: 414 ---KGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLL 470
Query: 170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHL---LEEPTSMEVQPMTEELLKQQKLNS 226
+ + +EE+ L ++R+ EQL +++L L L+E + Q + E + +Q + ++
Sbjct: 471 ETRELLEEV---LEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV-EHVRQQYQRDT 526
Query: 227 HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
+ + Q + H A L+ + Q+ A + LQ +L E S E Q QK
Sbjct: 527 EQLRRSMQDATQDH-AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKN------- 578
Query: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQ--QVALLDL 344
KE L++ ++E +L E + + + E+L Q +L Q +S G + + + LL
Sbjct: 579 KEDLRATKQELLQLRMEKEEMEEELGEKIEVL-QRELEQARASAGDTRQVEVLKKELLRT 637
Query: 345 QSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKAL 404
Q L Q E Q + R ++R+L ++ E E+Q N +L+K L
Sbjct: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQ-------NLQLQKTL 690
Query: 405 QQLQEELQNKSQQLRAWEAE-----------KYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
QQL+++ + S+ EAE + TQE+N + L EQ L+E
Sbjct: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILG-LEQQLKET 749
Query: 454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 513
R L+ + + +EA R+ DK LE + AL ++E L A
Sbjct: 750 RGLV----DGGEAVEA----------RLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
R + LE + L+ Q++ L +G + E L L+ K ++ R
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 574 KEQESI-------IQQLQTSLHD----RNKEVEDLS------ATLLCKLGPGQSEIAEEL 616
KE E I +QQLQ L D +EV D A+ K G S + +E
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE- 914
Query: 617 CQRLQRKERMLQDLLSDRNKQVLEHEM---EIQGLLQSVSTREQESQAAAEKLVQALMER 673
+QR + LQ ++R+ L+ E+ +QGL Q +++ A +L + L E+
Sbjct: 915 ---IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL-KGLEEK 970
Query: 674 NSELQA-LRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQT-------DQGSMQIPSRDD 725
S L+ L + + L + Q + T + +++ D+ S++ ++D
Sbjct: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
Query: 726 STSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAV 785
T L + E P ++L L ESQ +L LQ +
Sbjct: 1031 KTRLASSEGFQKPSASLSQL-------------------------ESQNQL--LQERLQA 1063
Query: 786 QEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVE 845
+E E V + L R ++ I+D + + D +D +L+ V L+ +V E
Sbjct: 1064 EEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKD-----QLSLRVKALKRQVDEAE 1118
Query: 846 SQGQEISGNRRQQLLLMLEGLVDERSRLNEALQA 879
+ + + G R++ + V+E+ +NE LQA
Sbjct: 1119 EEIERLDGLRKK-----AQREVEEQHEVNEQLQA 1147
Score = 105 bits (261), Expect = 3e-22
Identities = 149/715 (20%), Positives = 304/715 (42%), Gaps = 86/715 (12%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
L + L ++ L+LR E + A +E++ R+ EVE ++++ Q +
Sbjct: 476 LEEVLEGKQRVEEQLRLR----ERELTALKGALKEEVASRD----QEVEHVRQQYQRDTE 527
Query: 68 HLDKTWADVENLNSQNEAE----------LRRQFEERQQETEHVYELLENKIQLLQEESR 117
L ++ D ++ EAE L+R+ EE +ET H + + +E+ R
Sbjct: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKN----KEDLR 583
Query: 118 LAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDV---PGDQVKPDQYTEALAQRDKR 174
K E ++ E +E EL EK++ + + E GD + + + L + +
Sbjct: 584 ATKQELLQLRMEKEEMEE---ELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
Query: 175 IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
++EL +QE RE ++ L +L V+ L++Q L +T QQ
Sbjct: 641 LKELQAERQSQEVAGRHRDRELEKQLAVLR------VEADRGRELEEQNLQLQKTL--QQ 692
Query: 235 SVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE 294
D A + + + EAT +L ++ + L+ QE + + I L++ LK
Sbjct: 693 LRQDCEEASKAKMVAEAEAT--VLGQRRAAVETTLRETQEENDEFRRRILGLEQQLK--- 747
Query: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD-----LQSALF 349
E +++G A+LR+ L + + + E + +Q++ L L++ L
Sbjct: 748 ----ETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLE 803
Query: 350 CSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH----NQELRK--- 402
+Q + +L + + R L + + + + E E+QK + N+EL K
Sbjct: 804 EAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGE 863
Query: 403 ----ALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
ALQQLQ +L++ ++ R A+ + + + + LS + +Q R+ LQ
Sbjct: 864 DSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923
Query: 459 YRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDH 518
T ++ LL + Q + +A +R+ D++ L+ E+++ +L + E +
Sbjct: 924 ASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKN 983
Query: 519 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR---WQKE 575
+E L D ++ + + + L + + L +L+ ++++T+ + +QK
Sbjct: 984 TVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKP 1043
Query: 576 QESIIQ-QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDR 634
S+ Q + Q L + E+ T+L + ++L+RK + L + D
Sbjct: 1044 SASLSQLESQNQLLQERLQAEEREKTVL-----------QSTNRKLERKVKELSIQIEDE 1092
Query: 635 NKQVLEHE----MEIQGLLQSVSTREQESQ------AAAEKLVQALMERNSELQA 679
+ V + + + ++ L + V E+E + A++ V+ E N +LQA
Sbjct: 1093 RQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1147
Score = 80.9 bits (198), Expect = 5e-15
Identities = 127/608 (20%), Positives = 255/608 (41%), Gaps = 76/608 (12%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIEL--KVEVESLKRELQDKKQ 67
+ L K+E L++ +EE + +K E + ++ + +VE LK+EL ++
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
Query: 68 HLDKTWADVEN---LNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKN--E 122
L + A+ ++ + EL +Q + E + EL E +QL + +L ++ E
Sbjct: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
Query: 123 AARMAALVEAE------------------KECNLELSEKLKGVTKNWED----VPGDQVK 160
A++ + EAE +E N E ++ G+ + ++ V G +
Sbjct: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
Query: 161 PDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLK 220
+ + L + + ++L ++L A + L+ K+ L LEE + + +
Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQ----RGLARLGQE 815
Query: 221 QQKLN-SHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 279
QQ LN + E Q+ V AEL+E+ + + T L ++L ++ + K A + Q Q
Sbjct: 816 QQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQ 875
Query: 280 -DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQ 338
+ + + + +R+ ++ E + +++L Q ++ +L + S A++
Sbjct: 876 LEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRL-----QDEIQRLRQALQASQAERD 930
Query: 339 VALLD---LQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK 395
A LD L L + E + +R + RQL ++ V +E E + E
Sbjct: 931 TARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTD 990
Query: 396 HNQELRKALQQLQEELQNKSQQLRAWEAEKYN------EIRTQ---EQNIQHLNHSLSHK 446
R + QL+ EL + + E +K + +++T+ + Q + SLS
Sbjct: 991 RVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQL 1050
Query: 447 EQLLQEFRELLQYRDNSDKTLEANEMLLEKL-----------RQRIHD-------KAVAL 488
E Q +E LQ + L++ LE+ RQ ++D + AL
Sbjct: 1051 ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKAL 1110
Query: 489 ERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNE------ATMQSMESLLR 542
+R +DE +E + ++ + V E+ E+L+ + S E A+ + ES L+
Sbjct: 1111 KRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALK 1170
Query: 543 AKGLEVEQ 550
+GL ++
Sbjct: 1171 NEGLSSDE 1178
Score = 73.6 bits (179), Expect = 9e-13
Identities = 152/701 (21%), Positives = 283/701 (40%), Gaps = 81/701 (11%)
Query: 281 GTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVA 340
G++ ++K T+ RE E + K+ +L + Q + SS T Q
Sbjct: 309 GSVDHMKATIYGILREGSS-----ESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGE 363
Query: 341 LL----DLQSALFCSQLEIQKLQR----VVRQKERQLADAKQCVQFVEAAAHESEQQKEA 392
L +LQ L + QKL+ + RQ E + + + + +E E++Q +
Sbjct: 364 LTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKE 423
Query: 393 SWK------HNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK 446
++LR L+ ELQNK + ++ E K ++ + + L L K
Sbjct: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK 483
Query: 447 ----EQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEK 502
EQL REL + + + + + +E +RQ+ L R++ +
Sbjct: 484 QRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL 543
Query: 503 EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK 562
E E +++ VR +LE + ++ Q + LRA E+ Q L+ K
Sbjct: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ-------LRMEK 596
Query: 563 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRL-- 620
EEME + + + ++Q + S D ++VE L LL + AE Q +
Sbjct: 597 EEMEEELGEKIEVLQRELEQARASAGD-TRQVEVLKKELLRTQEELKELQAERQSQEVAG 655
Query: 621 QRKERMLQDLL------SDRNKQVLEHEMEIQGLLQSVSTREQESQAA---AEKLVQALM 671
+ ++R L+ L +DR +++ E +++Q LQ + +E+ A AE L
Sbjct: 656 RHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLG 715
Query: 672 ERNSELQ-ALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIP-SRDDSTSL 729
+R + ++ LR+ D + QQ + T G + + ++ R ++
Sbjct: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775
Query: 730 TAKEDVSIPRSTLGDLDTV-AGLEKELSNAKEELELMAKKER-------ESQMELSALQS 781
+E ++ + G L LE L A+ L + ++++ E + L+
Sbjct: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
Query: 782 MMAVQEEELQVQAADMESLTRNIQ-IKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
A EE+ ++ ++ L + ++ I ED + LQ ED E+ +EV + +
Sbjct: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY--KEKARREVADAQRQ 893
Query: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
S+ ++ SG L L DE RL +ALQA + A +++ D
Sbjct: 894 AKDWASEAEKTSGG--------LSRLQDEIQRLRQALQASQ----------AERDTARLD 935
Query: 901 RTLQVE----LEGAQVLRSRLEEVLGRSL----ERLNRLET 933
+ L + LE + R ++ R L E+++RLET
Sbjct: 936 KELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLET 976
Score = 42.7 bits (99), Expect = 0.002
Identities = 34/138 (24%), Positives = 69/138 (50%), Gaps = 18/138 (13%)
Query: 2 SNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRE 61
S G++ S L+ L+ +N L+ R+ EER + +++ + ++ EL +++E ++
Sbjct: 1037 SEGFQKPSASLSQLESQNQLLQERLQ-AEEREKTVLQSTNRKLERKVKELSIQIEDERQH 1095
Query: 62 LQDKKQHL-----------DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
+ D+K L D+ ++E L+ LR++ + +E V E L+ +I+
Sbjct: 1096 VNDQKDQLSLRVKALKRQVDEAEEEIERLDG-----LRKKAQREVEEQHEVNEQLQARIK 1150
Query: 111 LLQEES-RLAKNEAARMA 127
L+++S R A AA A
Sbjct: 1151 SLEKDSWRKASRSAAESA 1168
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 129 bits (325), Expect = 1e-29
Identities = 203/972 (20%), Positives = 404/972 (41%), Gaps = 162/972 (16%)
Query: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWA--DVENLNSQNEAELR 88
E+ ++K + D+ + EL+ +++ LK +L K++ L A D E L+ N ++
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 89 RQFEERQQETEHVYEL-------LENKIQLLQEESRLAKNE--------AARMAALVEAE 133
R+ + + E + +E E + + L EE K E AA+ + E
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 134 KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS 193
+E EL + L+ TKN E Q++ + A A +EEL++ L +R L
Sbjct: 1174 QEV-AELKKALEEETKNHEA----QIQDMRQRHATA-----LEELSEQLEQAKRFKANLE 1223
Query: 194 REKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEA 253
+ KQ L T + ++L+Q K S ++ D+ + EL K+ + +
Sbjct: 1224 KNKQGL------ETDNKELACEVKVLQQVKAESEH----KRKKLDAQVQELHAKVSEGDR 1273
Query: 254 TNKILQEKLNEMSYELKCAQ---ESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDT 310
L EK +++ EL E ++K+ +L+S+ ++T+EL Q +T
Sbjct: 1274 LRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ-----EET 1328
Query: 311 MAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK-LQRVVRQKERQL 369
KL S++ QL + + QQ+ + E +K L++ V + QL
Sbjct: 1329 RQKLNL---SSRIRQLEEEKNSLQEQQE------------EEEEARKNLEKQVLALQSQL 1373
Query: 370 ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEI 429
AD K+ V E+ K+ K + AL Q EE +L + E+
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAE----ALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 430 RTQEQNIQHLNHSLSHKEQLLQEFRELL-QYRDNSDKTLEANEMLLEKLRQRIHDKAVAL 488
++ H S+ E+ ++F +LL + + S + E + + R++ KA++L
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK-ETKALSL 1488
Query: 489 ERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEV 548
RA++E A EE E++ +QLR + DL +D + N + +E RA +V
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADME----DLMSSKDDVGKN---VHELEKSKRALEQQV 1541
Query: 549 EQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPG 608
E++ T + L+ + E R + +++ Q + L R+++ E+ L+ ++
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVREL 1601
Query: 609 QSEIAEELCQR---LQRKERMLQDL------LSDRNK---QVLEHEMEIQGLLQSVSTRE 656
++E+ +E QR + K++M DL + NK +V++ ++Q ++
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 657 QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQG 716
+E++A+ +++ E +L++L + ++ + + + AE + T+
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 717 SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME- 775
S + D+ L A+ +A LE+EL + +EL+ + R++ ++
Sbjct: 1722 SGKSALLDEKRRLEAR---------------IAQLEEELEEEQSNMELLNDRFRKTTLQV 1766
Query: 776 -------------------------------------------------LSALQSMMAVQ 786
+SAL++ +
Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 1826
Query: 787 EEELQVQAADMESLTRNIQIKEDLIKDLQMQLVD-----PEDIPAMERLTQEVLLLREKV 841
EE+L+ +A + + + ++ E +K++ MQ+ D + ME+ + L+ ++
Sbjct: 1827 EEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL 1886
Query: 842 ASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE-RQLYSSLVKFHAHPESSERD 900
E + + +RR+ L+ +D+ + NE L E L + L + SS R
Sbjct: 1887 EEAEEEATRANASRRK-----LQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRS 1941
Query: 901 RTLQVELEGAQV 912
Q+ LEGA +
Sbjct: 1942 GRRQLHLEGASL 1953
Score = 122 bits (305), Expect = 2e-27
Identities = 206/936 (22%), Positives = 405/936 (43%), Gaps = 128/936 (13%)
Query: 32 RMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL-DKTWADVENLNSQNEA----- 85
R +++ +A E++ K E + +VE E++ K Q L ++ E L ++ E
Sbjct: 849 RQEEELQAKDEELLKVK-EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 86 ELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 145
E+R + ++QE E + LE++++ +E +++ +NE +M A ++ +E +L E+
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE---QLDEEEG 964
Query: 146 GVTK-NWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVE---QLSREKQQLLH 201
K E V + E L D+ + + + ++R+ E QL+ E+++ +
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 202 LLEEPTSMEVQ-PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQE 260
L + EV EE LK+++ E ++ + D +LQ++I + LQ
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL-DGETTDLQDQIAE-------LQA 1076
Query: 261 KLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQ 320
+++E+ +L+ A++ + Q + ETL +N+ + +RE+ Q
Sbjct: 1077 QIDEL--KLQLAKKEEELQGALARGDDETLH---------------KNNALKVVREL--Q 1117
Query: 321 SQLGQLH---SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ 377
+Q+ +L SE S + + DL L + E++ ++ +Q V
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 378 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 437
++ A E + EA Q++R+ EEL + +Q + ++A + +Q ++
Sbjct: 1178 ELKKALEEETKNHEA---QIQDMRQRHATALEELSEQLEQAKRFKA----NLEKNKQGLE 1230
Query: 438 HLNHSLSHKEQLLQEFRELLQYR----DNSDKTLEANEMLLEKLRQRIHDKAVALERAID 493
N L+ + ++LQ+ + +++ D + L A ++LR + +KA L+ +D
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 494 EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLST 553
+ LEE EK+ + + L+ +++L E T Q + R + LE E+
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--QEETRQKLNLSSRIRQLEEEK--- 1345
Query: 554 TCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATL--LCKLGPGQSE 611
+LQ +EE E +K E + LQ+ L D K+V+D T+ L + +
Sbjct: 1346 --NSLQEQQEEEEEA----RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 612 IAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQES---QAAAEKLVQ 668
AE L QRL+ K L +N+ + E+ L + + Q + + +K Q
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRL----QQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 669 ALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTS 728
L E S +Y RD ++A K+T S+ +R +
Sbjct: 1456 LLAEEKS---ISARYAEERDRAEAEA--------------REKETKALSL---ARALEEA 1495
Query: 729 LTAKEDVSIPRSTL-GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQE 787
L AKE+ L D++ + + ++ ELE K +R + ++ +++ + E
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE---KSKRALEQQVEEMRTQLEELE 1552
Query: 788 EELQVQAADMESLTRNIQ-IKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVES 846
+ELQ L N+Q +K +DLQ + E+ ++ LL ++V +E+
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTR---------DEQNEEKKRLLIKQVRELEA 1603
Query: 847 QGQEISGNRRQQLLLMLE------GLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
E+ R+Q+ L + L D +++ A +A ++ L K A + +R
Sbjct: 1604 ---ELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR- 1659
Query: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAA 936
ELE A+ R +E+ +S E +L++L A
Sbjct: 1660 -----ELEEARASR---DEIFAQSKESEKKLKSLEA 1687
Score = 98.6 bits (244), Expect = 3e-20
Identities = 150/681 (22%), Positives = 296/681 (43%), Gaps = 79/681 (11%)
Query: 23 KLRIYFLEERMQQKYEASR-----EDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVE 77
+LR+ E+ + + E E+ K+ I+ + SL+ +LQD ++ L +
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332
Query: 78 NLNSQNEA--ELRRQFEERQQETEHVYELLENKIQLLQEE----SRLAKNEAARMAALVE 131
NL+S+ E + +E+Q+E E + LE ++ LQ + + ++ + +L E
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 132 AEKECNLE---LSEKLKGV---------TKN-----WEDVPGDQVKPDQYTEALAQRDKR 174
A+K+ + LS++L+ TKN +D+ D Q L ++ K+
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 175 IEEL---NQSLAA---QER-LVEQLSREKQ----QLLHLLEEPTSMEVQPMTEELLKQQK 223
++L +S++A +ER E +REK+ L LEE ++E + E KQ +
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE--ALEAKEEFERQNKQLR 1510
Query: 224 LNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTI 283
+ + ++ V ++ EL++ + E + ++ +L E+ EL+ +++ + + +
Sbjct: 1511 ADMEDLMSSKDDVG-KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 284 QNLK----ETLKSRERETEELYQVIEGQ-NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQ 338
Q +K L++R+ + EE +++ Q + A+L + Q L S + +
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV------ASKKKME 1623
Query: 339 VALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQ 398
+ L DL++ + + ++ + +R+ + Q+ D ++ ++ A+ E Q + S K +
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 399 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
L + QLQEEL + + R E E+ ++ + +S S K LL E R L
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQER-------DELADEITNSASGKSALLDEKRRLEA 1736
Query: 459 YRDNSDKTLEANEMLLEKLRQRIHDKAV---ALERAIDEKFSALEEKEKELRQLRLAVRE 515
++ LE + +E L R + L + + SA ++ + +QL +E
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 516 RDHDLERLRDVLSSN-EATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 574
L+ L + S +AT+ ++E+ + G EQL + + R +K
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKI---GQLEEQLEQEAKE----RAAANKLVRRTEK 1849
Query: 575 EQESIIQQLQTSLHDRNKEVEDL-SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ + I Q++ ++ E + A K Q E AEE R R LQ L D
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 634 RNKQVLEHEMEIQGLLQSVST 654
+ +GL + VST
Sbjct: 1910 ATE-------ANEGLSREVST 1923
Score = 85.9 bits (211), Expect = 2e-16
Identities = 133/617 (21%), Positives = 253/617 (41%), Gaps = 59/617 (9%)
Query: 354 EIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQ--------------- 398
+++ L +V RQ+E A ++ ++ E + +E KH Q
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 399 -ELRKALQQLQEELQNKSQQL---------RAWEAEKYNEIRTQEQ-----NIQHLNHSL 443
EL ++++ L K Q+L R E E+ N+I E+ +IQ L L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 444 SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKE 503
+E Q+ + + K +E +LLE + + +E I E S L E+E
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 504 KELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKE 563
++ + L +++ + L + L E T Q +E R E L LQ +
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 564 EMETKFSRWQKE-QESIIQQLQTSLHDRN--KEVEDLSATLLCKLGPGQSEIAEELCQRL 620
E++ + ++ ++E Q ++ + +LH N K V +L A + +SE A +
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR--NKA 1137
Query: 621 QRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST-REQESQAAAEKLVQALMERNSELQA 679
++++R L + L + K LE ++ Q + T REQE + L + +++Q
Sbjct: 1138 EKQKRDLSEEL-EALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 680 LRQ-YLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSM----------QIPSRDDSTS 728
+RQ + + L Q + + G +TD + + S
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 729 LTAKEDVSIPRSTLGD------LDTVAGLEKELSNAKEELELMAKKERESQMELSALQSM 782
L A+ + + GD + + L+ EL N LE KK + + ++L+S
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 783 MAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA 842
+ +E LQ + +L+ I+ E+ LQ Q + E+ A + L ++VL L+ ++A
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE--ARKNLEKQVLALQSQLA 1374
Query: 843 SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRT 902
+ + + G + L + L+ + L++ L+ + Y L K + D
Sbjct: 1375 DTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD-- 1431
Query: 903 LQVELEGAQVLRSRLEE 919
L V+L+ + + S LE+
Sbjct: 1432 LTVDLDHQRQVASNLEK 1448
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (317), Expect = 9e-29
Identities = 209/1011 (20%), Positives = 420/1011 (41%), Gaps = 117/1011 (11%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKR---NIELKVEVES 57
TL + NDL+ + + + EER Q + EA +++ +R E+ E+ +
Sbjct: 885 TLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 944
Query: 58 LKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESR 117
KR+L+D+ L K D+E ++ E E +H ENK++ L EE
Sbjct: 945 KKRKLEDECSELKKDIDDLELTLAKVEKE------------KHA---TENKVKNLTEE-- 987
Query: 118 LAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE 177
MA L E + E + + +D+ ++ K + T+A + ++++++
Sbjct: 988 --------MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 178 LNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
L SL +++L L R K++L L L +E + M+++ ++L ++ K E + Q
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-SIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 235 SVSD----------------SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQK 278
+ D + + EL+E+I+ A+ +++ +++S EL+ E ++
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 279 QDGTIQNLKETLKSRERETEELYQVIEGQN---------------DTMAKLREMLHQSQL 323
G E K RE E +++ + +E D++A+L E + L
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI--DNL 1216
Query: 324 GQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 383
++ ++ ++ + DL S + L+++ R E QL++ K + +
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 384 HESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL 443
++ Q+ + E + L + + + S+ +A+ ++ E++ Q + ++L
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF-TQQIEELKRQLEEEIKAKNAL 1335
Query: 444 SHKEQLLQEFRELL--QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
+H Q + +LL QY + + E + L K + E ++ LEE
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKAEL-QRALSKANTEVAQWRTKYETDAIQRTEELEE 1394
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
+K+L Q A E +E + +S E T Q +++ + L+VE+ + C L
Sbjct: 1395 AKKKLAQRLQAAEEH---VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
+ + + W+++ E +L+ S KE L T L K+ E ++L + L+
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEAS----QKEARSL-GTELFKIKNAYEESLDQL-ETLK 1505
Query: 622 RKERMLQDLLSDRNKQVLE-----HEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSE 676
R+ + LQ +SD +Q+ E HE+E + + V + E QAA E+ +L +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELE--KIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 677 L----QALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK 732
+ L Q D +++ Q + + +I SR+D+ L K
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 733 EDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMM---AVQEEE 789
+ GDL+ +E +L++A + R +Q L Q + +E+
Sbjct: 1624 ME--------GDLNE---MEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQED 1672
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQ 849
L+ Q A +E R + + I++L+ L E + + QE+L E+V + +Q
Sbjct: 1673 LKEQLAMVE---RRANLLQAEIEELRATLEQTE--RSRKIAEQELLDASERVQLLHTQNT 1727
Query: 850 EISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG 909
+ +++ + + + L EA AE + ++ E ++++ LE
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 910 AQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
++ +E+ + RL+ E LA GG E E +E E
Sbjct: 1788 ---MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE 1835
Score = 119 bits (298), Expect = 1e-26
Identities = 204/994 (20%), Positives = 419/994 (42%), Gaps = 144/994 (14%)
Query: 3 NGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYE--ASRED----IYKRNIELKVEVE 56
N + L++ + L + L L+E QQ + + ED + K I+L+ +V+
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
Query: 57 SLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEES 116
L+ L+ +K K D+E + E +L+ E +EN+ Q L E+
Sbjct: 1039 DLEGSLEQEK----KLRMDLERAKRKLEGDLKLAQESIMD--------IENEKQQLDEKL 1086
Query: 117 RLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIE 176
+ + E + + + +E E+ ++L +K+K + E++ ++++ ++ + A A++ +
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE-EEIEAERASRAKAEKQR--S 1143
Query: 177 ELNQSLAA-QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQS 235
+L++ L ERL E Q+ + + E Q M +L ++ L T T +
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQKMRRDL-EEATLQHEATAATLRK 1200
Query: 236 VSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 295
+AEL E+I + + L+++ +EM E+ + + NL++ ++ E
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED 1260
Query: 296 ETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS---- 351
+ EL E Q + L +Q G+L + G Q LD + AL
Sbjct: 1261 QLSELKSKEEEQQRLINDLT-----AQRGRLQTESGEFSRQ-----LDEKEALVSQLSRG 1310
Query: 352 -QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE---QQKEASWKHNQELRKALQQL 407
Q Q+++ + RQ E ++ ++++ H+ + +Q E + EL++AL +
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370
Query: 408 QEELQN-----------KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH----KEQLLQE 452
E+ ++++L + + ++ E++++ +N + K++L E
Sbjct: 1371 NTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 453 FRELLQ--YRDNS-----DKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS-------- 497
+L+ R N+ DK + +L + +Q+ + LE + E S
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490
Query: 498 --ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC 555
A EE +L L+ + ++ L + ++ + +E + + E +L
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550
Query: 556 QNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEE 615
+ + E E K R Q E + ++ + ++++E++ L + + QS + E
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610
Query: 616 LCQR---LQRKERMLQDL------LSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAA 663
+ R ++ K++M DL L+ N+ + L + QG+L+ ++ +
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 664 EKLVQ--ALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIP 721
E L + A++ER + L QA I +A + T K +Q +
Sbjct: 1671 EDLKEQLAMVERRANLL--------------QAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 722 SR-----DDSTSL--TAKE---DVSIPRSTLGD-LDTVAGLEKELSNAKEELELMA---K 767
R +TSL T K+ D+S + + D L E++ A + +MA K
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 768 KERESQMELSALQSMMAVQEEELQVQAADMESLT-----RNIQIKEDLIKDLQMQLVDPE 822
KE+++ L ++ M ++LQ++ + E L + IQ E +++L+ ++ +
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDE-----RSRLNEAL 877
+R + V LR+ V+ + +R+ +L L+ LVD+ +S +A
Sbjct: 1837 -----KRNAEAVKGLRKHERRVKELTYQTEEDRKN--ILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 878 QAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911
+AE Q ++L KF R LQ ELE A+
Sbjct: 1890 EAEEQSNTNLAKF----------RKLQHELEEAE 1913
Score = 82.0 bits (201), Expect = 2e-15
Identities = 149/766 (19%), Positives = 304/766 (39%), Gaps = 148/766 (19%)
Query: 284 QNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD 343
Q +K+ L E + +EL + M L + + QL +EG + A+++
Sbjct: 863 QKIKDELAKSEAKRKEL-------EEKMVTLLKEKNDLQLQVQAEAEGLADAEER----- 910
Query: 344 LQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKA 403
C QL K+Q + KE E A E E E + K ++L
Sbjct: 911 ------CDQLIKTKIQLEAKIKE-----------VTERAEDEEEINAELTAK-KRKLEDE 952
Query: 404 LQQLQEELQNKSQQLRAWEAEKY---NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
+L++++ + L E EK+ N+++ + + L+ +++ +L +E + L +
Sbjct: 953 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA---KLTKEKKALQEAH 1009
Query: 461 DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL 520
+ L+A E + L + + LE+ +D+ +LE+++K L A R+ + DL
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKA----KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1065
Query: 521 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ------- 573
+ ++ + E Q ++ L+ K E+ L + ++ Q L +++ K Q
Sbjct: 1066 KLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125
Query: 574 ---------------------------------------------KEQESIIQQLQTSLH 588
K++E+ Q+++ L
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 589 DRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGL 648
+ + E +ATL K +E+ E++ LQR ++ L+ K+ E +MEI L
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQI-DNLQRVKQKLE-------KEKSEMKMEIDDL 1237
Query: 649 LQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGC 708
+V T +++ EK+ + L ++ SEL++ + + L++ + + T +G
Sbjct: 1238 ASNVET-VSKAKGNLEKMCRTLEDQLSELKSKEE---EQQRLINDLTAQRGRLQ-TESGE 1292
Query: 709 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 768
+Q D+ + ++ + R ++ L L +++ + +L+ ++
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 769 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAME 828
E Q + LQ ++ E+ E T IQ E+L ++ + +L ++
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYE--TDAIQRTEEL-EEAKKKLAQ-----RLQ 1404
Query: 829 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLE------GLVDERSRLNEALQAE-- 880
+ V + K AS+E Q + N + L+L +E +D++ R + + AE
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQ-NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK 1463
Query: 881 -----------------RQLYSSLVKF-HAHPESSERDRTLQVELEGAQVLRSRLEEVLG 922
R L + L K +A+ ES ++ TL+ E + Q S L E +
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 923 RSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQ 968
+R++ LE + E E ++EE A H++
Sbjct: 1524 EGGKRIHELEKIK--------KQVEQEKCELQAALEEAEASLEHEE 1561
Score = 73.6 bits (179), Expect = 9e-13
Identities = 92/461 (19%), Positives = 200/461 (43%), Gaps = 49/461 (10%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L LK+EN +L+ I L E++ + + E ++ + + EL+
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA 1549
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE Q + ++E+ L
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609
Query: 115 ESRLAKNEAARMAALVEA---EKECNLELSEKLKG-VTKNWEDVPGDQVKPDQYTEALAQ 170
E R ++N+A R+ +E E E L + ++ +N+ + G +K Q A
Sbjct: 1610 EIR-SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQG-ILKDTQIHLDDAL 1667
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
R + E+L + LA ER L E ++L LE+ + ++ +Q+ L++ E
Sbjct: 1668 RSQ--EDLKEQLAMVERRANLLQAEIEELRATLEQ------TERSRKIAEQELLDASE-R 1718
Query: 231 ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETL 290
+ ++ L ++K+ E +Q ++ ++ E + A+E ++K + E L
Sbjct: 1719 VQLLHTQNTSLINTKKKL---ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEEL 1775
Query: 291 KSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
K + + L ++ + T+ L+ L +++ Q AL
Sbjct: 1776 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE----------------------QLALKG 1813
Query: 351 SQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRK--ALQQL 407
+ +IQKL+ VR+ E ++ ++ K+ + V+ + KE +++ ++ + LQ L
Sbjct: 1814 GKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQ 448
++LQ K + + E + T + L H L E+
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914
Score = 50.8 bits (120), Expect = 6e-06
Identities = 77/335 (22%), Positives = 140/335 (41%), Gaps = 43/335 (12%)
Query: 632 SDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNS---ELQALRQYLGGRD 688
++ K++ + E Q + ++ E + + EK+V L E+N ++QA + L +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 689 SLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK-----EDVSIPRSTLG 743
Q + Q E + D+ + + LTAK ++ S + +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDE-------EEINAELTAKKRKLEDECSELKKDID 961
Query: 744 DLD-TVAGLEKE-------LSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA 795
DL+ T+A +EKE + N EE+ + + + E ALQ ++LQ +
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 796 DMESLTRNIQIKEDLIKDLQMQLVDPEDI-----PAMERLTQEVLLLREKVASVESQGQE 850
+ +LT+ E + DL+ L + + A +L ++ L +E + +E
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE----- 1076
Query: 851 ISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGA 910
N +QQL L+ E S L ++ E+ L L K E R L+ E+E
Sbjct: 1077 ---NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK--KIKELQARIEELEEEIEAE 1131
Query: 911 QVLRSRLEEV---LGRSLERLNRLETLAAIGGAAA 942
+ R++ E+ L R LE ++ E L GGA +
Sbjct: 1132 RASRAKAEKQRSDLSRELEEIS--ERLEEAGGATS 1164
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (317), Expect = 9e-29
Identities = 209/1011 (20%), Positives = 420/1011 (41%), Gaps = 117/1011 (11%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKR---NIELKVEVES 57
TL + NDL+ + + + EER Q + EA +++ +R E+ E+ +
Sbjct: 885 TLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 944
Query: 58 LKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESR 117
KR+L+D+ L K D+E ++ E E +H ENK++ L EE
Sbjct: 945 KKRKLEDECSELKKDIDDLELTLAKVEKE------------KHA---TENKVKNLTEE-- 987
Query: 118 LAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE 177
MA L E + E + + +D+ ++ K + T+A + ++++++
Sbjct: 988 --------MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 178 LNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
L SL +++L L R K++L L L +E + M+++ ++L ++ K E + Q
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-SIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 235 SVSD----------------SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQK 278
+ D + + EL+E+I+ A+ +++ +++S EL+ E ++
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 279 QDGTIQNLKETLKSRERETEELYQVIEGQN---------------DTMAKLREMLHQSQL 323
G E K RE E +++ + +E D++A+L E + L
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI--DNL 1216
Query: 324 GQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 383
++ ++ ++ + DL S + L+++ R E QL++ K + +
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 384 HESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL 443
++ Q+ + E + L + + + S+ +A+ ++ E++ Q + ++L
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF-TQQIEELKRQLEEEIKAKNAL 1335
Query: 444 SHKEQLLQEFRELL--QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
+H Q + +LL QY + + E + L K + E ++ LEE
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKAEL-QRALSKANTEVAQWRTKYETDAIQRTEELEE 1394
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
+K+L Q A E +E + +S E T Q +++ + L+VE+ + C L
Sbjct: 1395 AKKKLAQRLQAAEEH---VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
+ + + W+++ E +L+ S KE L T L K+ E ++L + L+
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEAS----QKEARSL-GTELFKIKNAYEESLDQL-ETLK 1505
Query: 622 RKERMLQDLLSDRNKQVLE-----HEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSE 676
R+ + LQ +SD +Q+ E HE+E + + V + E QAA E+ +L +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELE--KIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 677 L----QALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK 732
+ L Q D +++ Q + + +I SR+D+ L K
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 733 EDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMM---AVQEEE 789
+ GDL+ +E +L++A + R +Q L Q + +E+
Sbjct: 1624 ME--------GDLNE---MEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQED 1672
Query: 790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQ 849
L+ Q A +E R + + I++L+ L E + + QE+L E+V + +Q
Sbjct: 1673 LKEQLAMVE---RRANLLQAEIEELRATLEQTE--RSRKIAEQELLDASERVQLLHTQNT 1727
Query: 850 EISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG 909
+ +++ + + + L EA AE + ++ E ++++ LE
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 910 AQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
++ +E+ + RL+ E LA GG E E +E E
Sbjct: 1788 ---MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE 1835
Score = 119 bits (298), Expect = 1e-26
Identities = 204/994 (20%), Positives = 419/994 (42%), Gaps = 144/994 (14%)
Query: 3 NGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYE--ASRED----IYKRNIELKVEVE 56
N + L++ + L + L L+E QQ + + ED + K I+L+ +V+
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
Query: 57 SLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEES 116
L+ L+ +K K D+E + E +L+ E +EN+ Q L E+
Sbjct: 1039 DLEGSLEQEK----KLRMDLERAKRKLEGDLKLAQESIMD--------IENEKQQLDEKL 1086
Query: 117 RLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIE 176
+ + E + + + +E E+ ++L +K+K + E++ ++++ ++ + A A++ +
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE-EEIEAERASRAKAEKQR--S 1143
Query: 177 ELNQSLAA-QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQS 235
+L++ L ERL E Q+ + + E Q M +L ++ L T T +
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQKMRRDL-EEATLQHEATAATLRK 1200
Query: 236 VSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 295
+AEL E+I + + L+++ +EM E+ + + NL++ ++ E
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED 1260
Query: 296 ETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS---- 351
+ EL E Q + L +Q G+L + G Q LD + AL
Sbjct: 1261 QLSELKSKEEEQQRLINDLT-----AQRGRLQTESGEFSRQ-----LDEKEALVSQLSRG 1310
Query: 352 -QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE---QQKEASWKHNQELRKALQQL 407
Q Q+++ + RQ E ++ ++++ H+ + +Q E + EL++AL +
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370
Query: 408 QEELQN-----------KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH----KEQLLQE 452
E+ ++++L + + ++ E++++ +N + K++L E
Sbjct: 1371 NTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 453 FRELLQ--YRDNS-----DKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS-------- 497
+L+ R N+ DK + +L + +Q+ + LE + E S
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490
Query: 498 --ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC 555
A EE +L L+ + ++ L + ++ + +E + + E +L
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550
Query: 556 QNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEE 615
+ + E E K R Q E + ++ + ++++E++ L + + QS + E
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610
Query: 616 LCQR---LQRKERMLQDL------LSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAA 663
+ R ++ K++M DL L+ N+ + L + QG+L+ ++ +
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 664 EKLVQ--ALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIP 721
E L + A++ER + L QA I +A + T K +Q +
Sbjct: 1671 EDLKEQLAMVERRANLL--------------QAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 722 SR-----DDSTSL--TAKE---DVSIPRSTLGD-LDTVAGLEKELSNAKEELELMA---K 767
R +TSL T K+ D+S + + D L E++ A + +MA K
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 768 KERESQMELSALQSMMAVQEEELQVQAADMESLT-----RNIQIKEDLIKDLQMQLVDPE 822
KE+++ L ++ M ++LQ++ + E L + IQ E +++L+ ++ +
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDE-----RSRLNEAL 877
+R + V LR+ V+ + +R+ +L L+ LVD+ +S +A
Sbjct: 1837 -----KRNAEAVKGLRKHERRVKELTYQTEEDRKN--ILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 878 QAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911
+AE Q ++L KF R LQ ELE A+
Sbjct: 1890 EAEEQSNTNLAKF----------RKLQHELEEAE 1913
Score = 82.0 bits (201), Expect = 2e-15
Identities = 149/766 (19%), Positives = 304/766 (39%), Gaps = 148/766 (19%)
Query: 284 QNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD 343
Q +K+ L E + +EL + M L + + QL +EG + A+++
Sbjct: 863 QKIKDELAKSEAKRKEL-------EEKMVTLLKEKNDLQLQVQAEAEGLADAEER----- 910
Query: 344 LQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKA 403
C QL K+Q + KE E A E E E + K ++L
Sbjct: 911 ------CDQLIKTKIQLEAKIKE-----------VTERAEDEEEINAELTAK-KRKLEDE 952
Query: 404 LQQLQEELQNKSQQLRAWEAEKY---NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
+L++++ + L E EK+ N+++ + + L+ +++ +L +E + L +
Sbjct: 953 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA---KLTKEKKALQEAH 1009
Query: 461 DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL 520
+ L+A E + L + + LE+ +D+ +LE+++K L A R+ + DL
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKA----KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1065
Query: 521 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ------- 573
+ ++ + E Q ++ L+ K E+ L + ++ Q L +++ K Q
Sbjct: 1066 KLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125
Query: 574 ---------------------------------------------KEQESIIQQLQTSLH 588
K++E+ Q+++ L
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 589 DRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGL 648
+ + E +ATL K +E+ E++ LQR ++ L+ K+ E +MEI L
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQI-DNLQRVKQKLE-------KEKSEMKMEIDDL 1237
Query: 649 LQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGC 708
+V T +++ EK+ + L ++ SEL++ + + L++ + + T +G
Sbjct: 1238 ASNVET-VSKAKGNLEKMCRTLEDQLSELKSKEE---EQQRLINDLTAQRGRLQ-TESGE 1292
Query: 709 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 768
+Q D+ + ++ + R ++ L L +++ + +L+ ++
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 769 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAME 828
E Q + LQ ++ E+ E T IQ E+L ++ + +L ++
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYE--TDAIQRTEEL-EEAKKKLAQ-----RLQ 1404
Query: 829 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLE------GLVDERSRLNEALQAE-- 880
+ V + K AS+E Q + N + L+L +E +D++ R + + AE
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQ-NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK 1463
Query: 881 -----------------RQLYSSLVKF-HAHPESSERDRTLQVELEGAQVLRSRLEEVLG 922
R L + L K +A+ ES ++ TL+ E + Q S L E +
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 923 RSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQ 968
+R++ LE + E E ++EE A H++
Sbjct: 1524 EGGKRIHELEKIK--------KQVEQEKCELQAALEEAEASLEHEE 1561
Score = 73.6 bits (179), Expect = 9e-13
Identities = 92/461 (19%), Positives = 200/461 (43%), Gaps = 49/461 (10%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L LK+EN +L+ I L E++ + + E ++ + + EL+
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA 1549
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE Q + ++E+ L
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609
Query: 115 ESRLAKNEAARMAALVEA---EKECNLELSEKLKG-VTKNWEDVPGDQVKPDQYTEALAQ 170
E R ++N+A R+ +E E E L + ++ +N+ + G +K Q A
Sbjct: 1610 EIR-SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQG-ILKDTQIHLDDAL 1667
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
R + E+L + LA ER L E ++L LE+ + ++ +Q+ L++ E
Sbjct: 1668 RSQ--EDLKEQLAMVERRANLLQAEIEELRATLEQ------TERSRKIAEQELLDASE-R 1718
Query: 231 ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETL 290
+ ++ L ++K+ E +Q ++ ++ E + A+E ++K + E L
Sbjct: 1719 VQLLHTQNTSLINTKKKL---ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEEL 1775
Query: 291 KSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
K + + L ++ + T+ L+ L +++ Q AL
Sbjct: 1776 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE----------------------QLALKG 1813
Query: 351 SQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRK--ALQQL 407
+ +IQKL+ VR+ E ++ ++ K+ + V+ + KE +++ ++ + LQ L
Sbjct: 1814 GKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQ 448
++LQ K + + E + T + L H L E+
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914
Score = 50.8 bits (120), Expect = 6e-06
Identities = 77/335 (22%), Positives = 140/335 (41%), Gaps = 43/335 (12%)
Query: 632 SDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNS---ELQALRQYLGGRD 688
++ K++ + E Q + ++ E + + EK+V L E+N ++QA + L +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 689 SLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK-----EDVSIPRSTLG 743
Q + Q E + D+ + + LTAK ++ S + +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDE-------EEINAELTAKKRKLEDECSELKKDID 961
Query: 744 DLD-TVAGLEKE-------LSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA 795
DL+ T+A +EKE + N EE+ + + + E ALQ ++LQ +
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 796 DMESLTRNIQIKEDLIKDLQMQLVDPEDI-----PAMERLTQEVLLLREKVASVESQGQE 850
+ +LT+ E + DL+ L + + A +L ++ L +E + +E
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE----- 1076
Query: 851 ISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGA 910
N +QQL L+ E S L ++ E+ L L K E R L+ E+E
Sbjct: 1077 ---NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK--KIKELQARIEELEEEIEAE 1131
Query: 911 QVLRSRLEEV---LGRSLERLNRLETLAAIGGAAA 942
+ R++ E+ L R LE ++ E L GGA +
Sbjct: 1132 RASRAKAEKQRSDLSRELEEIS--ERLEEAGGATS 1164
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 126 bits (316), Expect = 1e-28
Identities = 211/982 (21%), Positives = 414/982 (42%), Gaps = 177/982 (18%)
Query: 8 LSQHLNDLKKEN--FSLKLRIYFLE-ERMQQKYEASREDIYKRNIELKVEVESLKRELQD 64
+ + L+KE+ F K+ + + E ++MQ K++ RE +++ E+ LK+E
Sbjct: 376 MKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVRE-------QMEAEIAHLKQENGI 428
Query: 65 KKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 124
+ + T L S+ AEL + RQ V EL E +L QEE + K A
Sbjct: 429 LRDAVSNT---TNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEE--VQKKNAE 480
Query: 125 RMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA 184
+ A +L +L+ + WE+V + A+ + ++L A
Sbjct: 481 QAAT----------QLKVQLQEAERRWEEVQS------YIRKRTAEHEAAQQDLQSKFVA 524
Query: 185 QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
+E V+ L + L ++ +Q M E Q+++N E+ Q +
Sbjct: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE---QKRVNKEESLQMQ----------V 571
Query: 245 QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
Q+ ++Q EA +Q+ ++++ AQ S+ EEL++VI
Sbjct: 572 QDILEQNEALKAQIQQFHSQIA-----AQTSASVL-----------------AEELHKVI 609
Query: 305 EGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 364
++ + + + L +SE ++ L D+Q+ F + E+QKLQ + +
Sbjct: 610 AEKDKQIKQTEDSL---------ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 365 KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE 424
+ AAAHE E+ +++ + + ++R +QLQ E+ NK ++ + +
Sbjct: 661 QA--------------AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN-D 705
Query: 425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDK 484
+ ++++ Q +Q L +K+ ++++ + +Q +D KT+E LLE ++ K
Sbjct: 706 QNKALKSEVQKLQTLVSEQPNKD-VVEQMEKCIQEKDEKLKTVEE---LLETGLIQVATK 761
Query: 485 AVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK 544
L AI + S+L ++ ++L+ + +E L+ V+ + ++S+E LL A+
Sbjct: 762 EEEL-NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 545 GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ------ESIIQQLQTSLHDRNKEVEDLS 598
L+V T Q+L+ + ++ + Q E+ S +Q+LQ L + +++ +
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880
Query: 599 ATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQE 658
A L EE + L + LQD L + N+ + H E+ + +E
Sbjct: 881 AVL------------EEKEKDLANTGKWLQD-LQEENESLKAHVQEV----AQHNLKEAS 923
Query: 659 SQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE------VTPTGCLGKQ 712
S + E+L L E+ +EL+ L L R+S +S Q + + L +Q
Sbjct: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 713 TDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERES 772
Q + P ++ + ++ + I +GL EL + K+ +E KK E
Sbjct: 984 NYQQASSFPPHEELLKVISEREKEI-----------SGLWNELDSLKDAVEHQRKKNNER 1032
Query: 773 QMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDL------IKDLQMQLVDPEDIPA 826
Q ++ A++ ++ +E+ + S+ N+ E L K+ E++
Sbjct: 1033 QQQVEAVE----LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV 1088
Query: 827 MERLTQEV----LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDE-----RSRLNEAL 877
+E +E LL+ + +S E G +L L+ V++ + +++E+
Sbjct: 1089 LEHKLKEADEMHTLLQLECEKYKSVLAETEG-----ILQKLQRSVEQEENKWKVKVDESH 1143
Query: 878 QAERQLYSSLVKFHAHPE---SSERD--------RTLQVELEGAQVLRS----RLEEVLG 922
+ +Q+ SS E S +D L++ELE A++ RS + E+
Sbjct: 1144 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKA 1203
Query: 923 RSLERLNRLETLAAIGGAAAGD 944
+ E L +L T AGD
Sbjct: 1204 QLNETLTKLRTEQNERQKVAGD 1225
Score = 53.5 bits (127), Expect = 9e-07
Identities = 82/419 (19%), Positives = 187/419 (44%), Gaps = 63/419 (15%)
Query: 50 ELKVEVESLKRELQDKKQHLDKT------WADVENLNSQNEAELRR---QFEERQQETEH 100
+L+ E ESLK +Q+ QH K + ++E + + E EL+R +ER+ +
Sbjct: 899 DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 958
Query: 101 VYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVK 160
+LL++ +Q+E++L K++ ++ + E LK +++ +++ G +
Sbjct: 959 KTQLLQD----VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 1014
Query: 161 PDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREK------------QQLLHLLEEPT- 207
D +A+ + K+ E Q + A E +++ ++ + LH E+
Sbjct: 1015 LDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1074
Query: 208 --------SMEVQPMTEEL--------LKQQKLNSHETTITQQSVSDSHLAELQEKIQQT 251
S EV+ + +L L Q + +++ + + ++ L +LQ ++Q
Sbjct: 1075 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE---TEGILQKLQRSVEQE 1131
Query: 252 EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEG----Q 307
E K+ ++ ++ +++ + SS+++ +++ + +++ RE E L +E +
Sbjct: 1132 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMER 1191
Query: 308 NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKER 367
+ + ++RE+ ++QL + + T ++Q DL A Q+ +++ K
Sbjct: 1192 STYVTEVREL--KAQLNETLTKLRTEQNERQKVAGDLHKA--------QQSLELIQSKIV 1241
Query: 368 QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKY 426
+ A ++ + + +KE + L + + QLQ+ LQ +QQL E E Y
Sbjct: 1242 KAAGDTTVIENSDVSPETESSEKETM---SVSLNQTVTQLQQLLQAVNQQLTK-EKEHY 1296
Score = 44.7 bits (104), Expect = 4e-04
Identities = 57/282 (20%), Positives = 126/282 (44%), Gaps = 25/282 (8%)
Query: 46 KRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQE-------T 98
K+N E + +VE+++ E K+ L K + V ++ + E FE++ +E +
Sbjct: 1027 KKNNERQQQVEAVELEA---KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1083
Query: 99 EHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQ 158
E V ++LE+K++ E L + E + +++ + +L ++ W+
Sbjct: 1084 EEV-KVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWK------ 1136
Query: 159 VKPDQYTEALAQRDKRIEELNQSLA---AQERLVEQLSREKQQLLHLLEEPTSMEVQPMT 215
VK D+ + + Q Q L ++ + +E L RE++ L LE+ +T
Sbjct: 1137 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVT 1196
Query: 216 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES 275
E + +LN T+T+ + ++ + + + + +++Q K+ + + + E+
Sbjct: 1197 EVRELKAQLNE---TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVI-EN 1252
Query: 276 SQKQDGTIQNLKETLK-SRERETEELYQVIEGQNDTMAKLRE 316
S T + KET+ S + +L Q+++ N + K +E
Sbjct: 1253 SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1294
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 126 bits (316), Expect = 1e-28
Identities = 212/1007 (21%), Positives = 425/1007 (42%), Gaps = 100/1007 (9%)
Query: 12 LNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKV---------EVESLKREL 62
+++LK E SL +E+ +++ E E ++ +E ++ E E L+REL
Sbjct: 736 ISELKAETRSL------VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL 789
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
+ ++ E L + A R ++E+ QQE + + ++ L+EE A+ E
Sbjct: 790 AEAMAAQHTAESECEQLVKE-VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
Query: 123 ---AARMAALVEAEKECNL-----ELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR 174
A A +E+ E + EL+E + + + V +V+ + + L+ ++
Sbjct: 849 LQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEK 908
Query: 175 IEELNQSLAAQERLVEQLSREKQQLLH-LLEEPTSM-EVQPMTEELLKQQKLNSHETTIT 232
+ ++ +A E LV + +++ L++EP + QP E L++Q+ +T
Sbjct: 909 MAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQP---EWLEEQQGRQFCSTQA 965
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+ ++ ++++ A Q + E + + ++ G Q K+
Sbjct: 966 ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKA 1025
Query: 293 RERETE-ELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS 351
E E L + Q A L+E L + L EG Q+ L L++A
Sbjct: 1026 ARAELEMRLQNALNEQRVEFATLQEALAHA----LTEKEGKD--QELAKLRGLEAAQI-- 1077
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEEL 411
E+++L++ V+Q + QLA ++ A E+ + E + + LR + +L+++
Sbjct: 1078 -KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136
Query: 412 QNKSQQL----------RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYR 460
Q + +Q RA AE+ + + T + ++ L H + L REL +R
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
Query: 461 DN-SDKTLEANEMLLEKLRQRIH-DKAVALERAIDEKFSAL-------EEKEKELRQLRL 511
D + +E + R R ++ +L +++E+ S L E + KEL++L +
Sbjct: 1197 TKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVM 1256
Query: 512 AVRERDHDLER----LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 567
A E+ LE L+ +SN A S LR EV+ L + + E +
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERSSALRE---EVQSLREEAEKQRVASENLRQ 1313
Query: 568 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAE-----ELCQRLQR 622
+ + + E + Q+L+ + ++ + E +TL + Q+ ++E LCQ+LQ
Sbjct: 1314 ELTSQAERAEELGQELK-AWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372
Query: 623 KERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQ 682
+ Q R+++ LE + G L++ R Q L Q + E+ Q LR
Sbjct: 1373 E----QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA 1428
Query: 683 YLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 742
+S ++ G LG++ + G + D ++++ R+
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRG-LGERANLGRQFLEVELDQAREKYVQELAAVRA-- 1485
Query: 743 GDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
D +T +A +++E + ELE+M K +++++ + + ++L Q +E
Sbjct: 1486 -DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ 1544
Query: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
R Q K+ +++L +L D + ++ ++K+ +V++QG E S Q+L
Sbjct: 1545 RE-QTKQ--VEELSKKLADSDQASKVQ---------QQKLKAVQAQGGE-SQQEAQRLQA 1591
Query: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPES-SERDRTLQVELEGAQVLRSRLEEV 920
L L +++L++ QA + K H ++ ++++ LQ +L + L+ +E
Sbjct: 1592 QLNEL---QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE- 1647
Query: 921 LGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQ 967
L ERL A + A + T T S+E + AH Q
Sbjct: 1648 LRAEAERLGHELQQAGLKTKEA-EQTCRHLTAQVRSLEAQVAHADQQ 1693
Score = 115 bits (288), Expect = 2e-25
Identities = 239/1067 (22%), Positives = 433/1067 (40%), Gaps = 187/1067 (17%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
+ + +N L +EN L ++ +QQ +A E + + K E L+++ Q +K+
Sbjct: 309 MDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHS---KATQEWLEKQAQLEKE 365
Query: 68 HLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ--------LLQEESRLA 119
L D + L +NE L+ + + + EH+ +L +N Q +LQ E+
Sbjct: 366 -LSAALQDKKCLEEKNEI-LQGKLSQLE---EHLSQLQDNPPQEKGEVLGDVLQLET--L 418
Query: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQR---DKRIE 176
K EAA +AA + + +E+ E +G Q + LA+R ++ +
Sbjct: 419 KQEAATLAA-NNTQLQARVEMLETERG---------------QQEAKLLAERGHFEEEKQ 462
Query: 177 ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLK-QQKLNSHETTITQQS 235
+L+ + + + LS+ K++ LE+ + +T ++ +L + TI QQ
Sbjct: 463 QLSSLITDLQSSISNLSQAKEE----LEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 236 VSDSHL--------AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK 287
+ L A+L + +QQ E ++ L+ ++ ++S LK QK+ Q LK
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK------QKE----QQLK 568
Query: 288 ETLKSRERETEE-LYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ- 345
E + +E ++ Q+ + A LRE + L QL + E A+ ++ LQ
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRE--RDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 346 --SALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQ-KEASWKHNQELRK 402
A +Q + + QR + R++ + + CV+ HE++ Q E + E +K
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 403 ALQ---------QLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
A + QLQE+LQ + L+ + E R ++ +S +L E
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS---ELKAET 743
Query: 454 RELLQYRDNSDKTLEAN-------EMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKEL 506
R L++ K LE E L++L + + L R + E +A E E
Sbjct: 744 RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803
Query: 507 RQLRLAV---RER--DHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
QL V RER D E + E M E +A+ ++L + + +
Sbjct: 804 EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR----QELQEAKEKVAGI 859
Query: 562 KEEMETKFSRWQKEQESI-------IQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIA- 613
+ E + SR Q E + +QQ+Q K +DLS TL K+ E+A
Sbjct: 860 ESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS-TLQEKMAATSKEVAR 918
Query: 614 -EELCQRL-QRKERMLQDLL------SDRNKQVLEHEM-----EIQGLLQSVSTREQESQ 660
E L ++ +++E ++L+ DR + LE + Q LQ++ ++
Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978
Query: 661 AAAEKLVQALME-----------RNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCL 709
E+L ALME + E+ L Q G + ++ + + E+ L
Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
Query: 710 GKQ-TDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT--VAGLEKELSNAKEELELMA 766
+Q + ++Q + +LT KE + L L+ + LE+ K+ E +A
Sbjct: 1039 NEQRVEFATLQ---EALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095
Query: 767 KKERE------SQME-----------LSALQSMMAVQEEELQVQAADMESLTRNIQI--- 806
KKE+E +Q E L AL++ ++ E++ Q Q +SL R+++
Sbjct: 1096 KKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA 1155
Query: 807 ----KEDLIKDLQMQLVDP-----EDIPAMERLTQEVLLLREKV---ASVESQGQEISGN 854
++ ++ LQ QL + A+ +E+ R KV + E + +
Sbjct: 1156 SRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1215
Query: 855 RRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLR 914
RQ+ + ++ L +L+ E + + V ES E R + E E +Q L
Sbjct: 1216 GRQE--------AERKNSLISSLEEEVSILNRQV-LEKEGESKELKRLVMAESEKSQKLE 1266
Query: 915 SRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEA 961
RL RL + ET + +A + E S+ EEA
Sbjct: 1267 ERL---------RLLQAETAS---NSARAAERSSALREEVQSLREEA 1301
Score = 107 bits (268), Expect = 4e-23
Identities = 208/994 (20%), Positives = 393/994 (39%), Gaps = 142/994 (14%)
Query: 87 LRRQF-EERQQETEHVYELLENKIQLLQEESRLA--KNEAARMAALVEAEKECNLELSEK 143
L++Q +ER E EL EN+ L ++++++A + R+A L E + LE E
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKEL 278
Query: 144 LKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLL 203
+ KN + T L + K+ ++L + +R + QLS E L L
Sbjct: 279 EELRDKN-----------ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
Query: 204 EEPTS--MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 261
E S ++Q EL ++ + E Q + A LQ+K + E N+ILQ K
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDK-KCLEEKNEILQGK 386
Query: 262 LNEMSYELKCAQESSQKQDGTIQN---LKETLKSR------------------------- 293
L+++ L Q++ ++ G + ETLK
Sbjct: 387 LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQ 446
Query: 294 -----------ERETEELYQVIEGQNDTMAKLREMLHQ-SQLGQLHSSEGTSPAQQQVAL 341
E E ++L +I +++ L + + Q Q H + T+ +
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
Query: 342 LDLQSALFCSQ-LEIQKLQRVVRQKERQLADA-KQCVQFVEAAAHESEQQKEASWKHNQE 399
L +A Q E+ L++ ++K+ QLA +Q Q + H+ EQ + + Q+
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 400 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 459
L++ ++ + Q+ +QQL E+ +R ++ ++ L K L+ ++ LQ
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 460 ----RDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA----------LEEKEKE 505
RD++ ++ + +L +++ + +E A E+ A L ++++
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 506 LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEM 565
+ +E+D E+L+ + S + T S+E R +E+ L+ +
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL 746
Query: 566 ETKFSRWQKEQE-------SIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQ 618
+ R +KE E + +LQ E E L L + AE C+
Sbjct: 747 VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAM--AAQHTAESECE 804
Query: 619 RLQRKERMLQDLLSDRNKQVLEH----EMEIQGLLQSVSTREQESQAAAEKLVQALMERN 674
+L ++ ++ D ++ ++ + ++ L + QE Q A EK+ A +E +
Sbjct: 805 QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV--AGIESH 862
Query: 675 SELQALRQY--LGGRDSLMSQAPISNQQAEVTPTGCLGK-QTDQGSMQIPSRD------- 724
SELQ RQ L + +++A Q+ EV T Q M S++
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Query: 725 ----DSTSLTAKEDVSIPRSTLGD-----LDTVAGLEKELSNAKEELELMAKKERESQME 775
TA ++ + GD L+ G ++ + + L+ M ++ + E
Sbjct: 923 VRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG--RQFCSTQAALQAMEREAEQMGNE 980
Query: 776 L----SALQSMMAVQEEELQVQAADMESLTR-------NIQIKEDLIKDLQMQLVDPEDI 824
L +AL Q+EE Q ++ LT+ ++ +++ +L+M+L + +
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 825 PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL-VDERSRLNEALQAERQL 883
+E T + L A E +G++ Q L L GL + L E Q +QL
Sbjct: 1041 QRVEFATLQEALAH---ALTEKEGKD-------QELAKLRGLEAAQIKELEELRQTVKQL 1090
Query: 884 YSSLVKFH--------AHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLA 935
L K A E++ R +LE + S+LE+ + E+ + LE
Sbjct: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE--R 1148
Query: 936 AIGGAAAGDDTEDTSTE-FTDSIEEEAAHHSHQQ 968
++ A D++ E +EE+A H Q
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182
Score = 89.4 bits (220), Expect = 2e-17
Identities = 153/702 (21%), Positives = 298/702 (42%), Gaps = 109/702 (15%)
Query: 50 ELKVEVESLKRELQDK-KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK 108
EL+ V+ LK +L K K+H + A Q+EA R + T E L +
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGA-------QSEAA------GRTEPTGPKLEALRAE 1128
Query: 109 IQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEAL 168
+ L+++ + + +A + +EAE+ E L+ + E+ ++ Q A
Sbjct: 1129 VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE-KAQELGHSQSALAS 1187
Query: 169 AQRDKRI--EELNQSLAAQERLVEQLSREKQQ------LLHLLEEPTSMEVQPMTEELLK 220
AQR+ ++ A++ Q++R +Q+ L+ LEE S+ + + E+ +
Sbjct: 1188 AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE 1247
Query: 221 QQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKI-LQEKLNEMSYELKCAQESSQKQ 279
++L + + +S L E +Q A+N E+ + + E++ +E ++KQ
Sbjct: 1248 SKEL---KRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ 1304
Query: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQV 339
+NL++ L S+ EEL Q ++ + + + L QL E TS Q V
Sbjct: 1305 RVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQL------EHTS-TQALV 1357
Query: 340 ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 399
+ L L + C QL+ ++ R +E E EQ K+A+ E
Sbjct: 1358 SEL-LPAKHLCQQLQAEQAAAEKRHRE------------------ELEQSKQAAGGLRAE 1398
Query: 400 LRKALQQLQE---------ELQNKSQQLRAWE---AEKYNEIRTQEQNIQHLNHSLSHKE 447
L +A ++L E E + +QQLRA + AE+ + ++ + N L +
Sbjct: 1399 LLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA 1458
Query: 448 QLLQEFR--ELLQYRDNSDKTLEA----NEMLLEKLRQRIHDKAVALE-----------R 490
L ++F EL Q R+ + L A E L ++++ A LE +
Sbjct: 1459 NLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVK 1518
Query: 491 AIDEKFSALEEKEK---ELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
++E+ EE++K ++ QL + RE+ +E L L+ ++ + + L+A +
Sbjct: 1519 VLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ 1578
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGP 607
+ Q LQ E++ + S QKEQ + +LQ + + +
Sbjct: 1579 GGESQQEAQRLQAQLNELQAQLS--QKEQAAEHYKLQMEKAKTHYDAK-----------K 1625
Query: 608 GQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQES-----QAA 662
Q++ +E + L++ ++ ++L ++ + L HE++ GL T+E E A
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAER--LGHELQQAGL----KTKEAEQTCRHLTAQ 1679
Query: 663 AEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVT 704
L + + +L+ L ++ D+L S+ P + Q +++
Sbjct: 1680 VRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLS 1721
Score = 80.9 bits (198), Expect = 5e-15
Identities = 109/500 (21%), Positives = 206/500 (41%), Gaps = 23/500 (4%)
Query: 15 LKKENFSLKL-RIYFLEERMQQKYEAS----REDIYKRNIELKVEVESLKRELQDKKQHL 69
L+KE S +L R+ E QK E + + + +L+ E+Q ++
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
+K ENL + ++ R EE QE + E K Q L + A ++ L
Sbjct: 1302 EKQRVASENLRQELTSQAERA-EELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360
Query: 130 VEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEEL---NQSLAAQE 186
+ A+ C +E+ ++ E++ + L + + + EL Q +A QE
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420
Query: 187 RLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQE 246
R +QL EK L + LL ++ E + + L + +E
Sbjct: 1421 RTAQQLRAEKASYAEQLS------MLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474
Query: 247 K-IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK-ETLKSRERETEELYQVI 304
K +Q+ A + +L E+ E + + + K + L+ R+R EE ++
Sbjct: 1475 KYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1534
Query: 305 EGQNDTMAKLREMLHQSQ--LGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
RE Q + +L S+ S QQQ L +Q+ SQ E Q+LQ +
Sbjct: 1535 AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQ-KLKAVQAQGGESQQEAQRLQAQL 1593
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE 422
+ + QL+ +Q + + +++ +A + NQEL++ L+ L E+LQ ++++LRA E
Sbjct: 1594 NELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL-EQLQKENKELRA-E 1651
Query: 423 AEKY-NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRI 481
AE+ +E++ + + H ++ + + D + L ++ + L+ R
Sbjct: 1652 AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711
Query: 482 HDKAVALERAIDEKFSALEE 501
L+ +ID + EE
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEE 1731
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 125 bits (315), Expect = 1e-28
Identities = 224/1017 (22%), Positives = 426/1017 (41%), Gaps = 129/1017 (12%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKR---NIELKVEVES 57
TL + NDL+ + S + EER +Q + EA +++ +R E+ E+ +
Sbjct: 882 TLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTA 941
Query: 58 LKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESR 117
KR+L+D+ L K D+E ++ E E +H ENK++ L EE
Sbjct: 942 KKRKLEDECSELKKDIDDLELTLAKVEKE------------KHA---TENKVKNLTEE-- 984
Query: 118 LAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE 177
MA L E + + E + + +D+ ++ K + T+A + ++++++
Sbjct: 985 --------MAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDD 1036
Query: 178 LNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
L SL +++L L R K++L L L +E T M+++ ++L ++ + E +
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST-MDMENDKQQLDEKLEKKEFEISNLIS 1095
Query: 235 SVSDSHLAE--LQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+ D E LQ+KI++ LQ ++ E+ E++ + S K + +L L+
Sbjct: 1096 KIEDEQAVEIQLQKKIKE-------LQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
EE Q + + K RE Q L E T + VA L + A ++
Sbjct: 1149 ISERLEEAGGATSAQVE-LNKKREAEFQKLRRDL--EEATLQHEAMVAALRKKHADSMAE 1205
Query: 353 L--EIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQL--- 407
L +I LQRV ++ E++ ++ K + + A + K K + L + +L
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK 1265
Query: 408 QEELQNKSQQLRAWEA-------EKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
+EE Q L A A E ++ ++ + L+ S Q ++E + L+
Sbjct: 1266 EEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 461 DNSDKTL--------EANEMLLEKLRQRIHDKAVALERAIDEKFSAL------------- 499
+ L ++L E+ + KA L+RA+ + S +
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEEEQEGKA-ELQRALSKANSEVAQWRTKYETDAIQ 1384
Query: 500 --EEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN 557
EE E+ ++L ++E + +E + +S E T Q +++ + L+VE+ + C
Sbjct: 1385 RTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAA 1444
Query: 558 LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELC 617
L + + S W+++ E + Q L KE LS T L K+ E ++L
Sbjct: 1445 LDKKQRNFDKVLSEWKQKYE----ETQAELEASQKESRSLS-TELFKVKNVYEESLDQL- 1498
Query: 618 QRLQRKERMLQDLLSDRNKQVLE-----HEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
+ L+R+ + LQ +SD +Q+ E HE+E + + V + E QAA E+ +L
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGKQIHELE--KIKKQVEQEKCEIQAALEEAEASLEH 1556
Query: 673 RNSEL----QALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTS 728
++ L Q D +++ Q + T + +I SR+D+
Sbjct: 1557 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR 1616
Query: 729 LTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMM--AVQ 786
+ K + GDL+ +E +L++A + R +Q L Q + A++
Sbjct: 1617 VKKKME--------GDLNE---MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALR 1665
Query: 787 -EEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVE 845
+E+L+ Q A +E R + + I++L L E + + QE+L E+V +
Sbjct: 1666 GQEDLKEQLAIVE---RRANLLQAEIEELWATLEQTE--RSRKIAEQELLDASERVQLLH 1720
Query: 846 SQGQEISGNRR--QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTL 903
+Q + ++ + + L+ V+E + E+ AE + ++ E ++++
Sbjct: 1721 TQNTSLINTKKKLENDVSQLQSEVEE--VIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778
Query: 904 QVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
LE ++ LE+ + RL+ E LA GG E E +E E
Sbjct: 1779 SAHLER---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1832
Score = 77.4 bits (189), Expect = 6e-14
Identities = 160/710 (22%), Positives = 299/710 (42%), Gaps = 108/710 (15%)
Query: 286 LKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ 345
+K LKS E E E MA ++E +++ A+ + +L+
Sbjct: 839 IKPLLKSAETEKE------------MATMKEEFQKTK---------DELAKSEAKRKELE 877
Query: 346 SALFCSQLEIQKLQRVVRQKERQLADAKQ-CVQFV------EAAAHESEQQKEASWKHNQ 398
+ E LQ V+ + LADA++ C Q + EA E ++ E + N
Sbjct: 878 EKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINA 937
Query: 399 ELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-R 454
EL ++L++E L+ L A+ E E +++L ++ ++ + + +
Sbjct: 938 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSK 997
Query: 455 ELLQYRDNSDKTLEANEMLLEKLRQRIHDKA-VALERAIDEKFSALEEKEKELRQLRLAV 513
E ++ +TL+ ++ E+ + I KA LE+ +D+ +LE+++K L A
Sbjct: 998 EKKALQETHQQTLD--DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1055
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
R+ + DL+ ++ E Q ++ L K E+ L + ++ Q ++ +++ K Q
Sbjct: 1056 RKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQ 1115
Query: 574 KEQESIIQQLQTSLHDR---NKEVEDLSATLLCKLGPGQSEIAEEL----------CQRL 620
E + ++++ R K+ DLS L EI+E L +
Sbjct: 1116 ARIEELGEEIEAERASRAKAEKQRSDLSREL--------EEISERLEEAGGATSAQVELN 1167
Query: 621 QRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQAL 680
+++E Q L D + L+HE + L R++ + + AE L E+ LQ +
Sbjct: 1168 KKREAEFQKLRRDLEEATLQHEAMVAAL------RKKHADSMAE-----LGEQIDNLQRV 1216
Query: 681 RQYLGGRDSLMSQAP---ISNQQAEVTPTGCLGKQ----TDQGSMQIPSRDDSTSLTAKE 733
+Q L S + SN +A G L K DQ S ++ L
Sbjct: 1217 KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI--N 1274
Query: 734 DVSIPRSTL--------GDLDTVAGLEKELSNAK-------EELELMAKKERESQMELS- 777
D++ R+ L LD L +LS +K EEL+ ++E +++ L+
Sbjct: 1275 DLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAH 1334
Query: 778 ALQS------MMAVQEEELQVQAADME-SLTR-NIQIKEDLIKDLQMQLVDPEDI-PAME 828
ALQS ++ Q EE Q A+++ +L++ N ++ + K + E++ A +
Sbjct: 1335 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1394
Query: 829 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLV 888
+L Q + E V +V ++ + +Q+L +E L+ + R N A A + +
Sbjct: 1395 KLAQRLQEAEEHVEAVNAKCASLE-KTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFD 1453
Query: 889 KFHAHPESSERDRTLQVELEGAQ----VLRSRLEEVLGRSLERLNRLETL 934
K + E ++ Q ELE +Q L + L +V E L++LETL
Sbjct: 1454 KVLS--EWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL 1501
Score = 71.6 bits (174), Expect = 3e-12
Identities = 98/465 (21%), Positives = 217/465 (46%), Gaps = 47/465 (10%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L L++EN +L+ I L E++ + + E ++ + + E++
Sbjct: 1487 VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA 1546
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE Q + ++E L
Sbjct: 1547 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606
Query: 115 ESRLAKNEAARMAALVEA---EKECNLELSEKLKGVT-KNWEDVPGDQVKPDQYTEALAQ 170
E R ++N+A R+ +E E E L + +L + +N+ + G +K Q A
Sbjct: 1607 EIR-SRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGI-LKETQLHLDDAL 1664
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELL----KQQKLNS 226
R + E+L + LA ER L E ++L LE+ T + +ELL + Q L++
Sbjct: 1665 RGQ--EDLKEQLAIVERRANLLQAEIEELWATLEQ-TERSRKIAEQELLDASERVQLLHT 1721
Query: 227 HETT-ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE-------MSYELKCAQESSQK 278
T+ I + ++ +++LQ ++++ ++ +EK + M+ ELK Q++S
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 279 QDGTIQNLKETLKSRERETEELYQV-IEGQNDTMAKL----REMLHQSQLGQLHSSE--- 330
+ +NL++T+K + +E Q+ ++G + KL RE+ + + Q ++E
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK 1841
Query: 331 GTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
G +++V L Q+ + + +LQ +V + + ++ K+ A E+E+Q
Sbjct: 1842 GLRKHERRVKELTYQTEE--DRKNVLRLQDLVDKLQAKVKSYKR-------QAEEAEEQS 1892
Query: 391 EASWKHNQELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQ 432
A+ ++L+ L++ +E +++ +LR E + +I +
Sbjct: 1893 NANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 125 bits (314), Expect = 2e-28
Identities = 191/995 (19%), Positives = 416/995 (41%), Gaps = 112/995 (11%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRN------IELKVEVESLKRELQ 63
+ + L K L+ ++ + ER++ + E + E K+ ELK +++ L+ L
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA 962
Query: 64 DKKQHLDKTWADVENLNSQ---------NEAELRRQFEERQQETEHVYELLENKIQLLQE 114
++ T V+NL + + ++ +E Q+ + E+K+ L +
Sbjct: 963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022
Query: 115 ESRLAKNEAARMAALVEAEKECNLEL---SEKLKGVTK-NWEDVPGDQVKPDQYTEALAQ 170
+ + + +E EK+ ++L KL+G K E + + Q E L +
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKK 1082
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
+D + LN + ++ L QL ++ ++L +EE + EEL E
Sbjct: 1083 KDFELNALNARIEDEQALGSQLQKKLKELQARIEE--------LEEEL---------EAE 1125
Query: 231 ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETL 290
T ++ + ++L ++++ + E+L E E ++K++ Q ++ L
Sbjct: 1126 RTARAKVEKLRSDLSRELEE-------ISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 291 KSRERETEELYQVIEGQN-DTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALF 349
+ + E + ++ D++A+L E + L ++ ++ ++ L D+ S +
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQI--DNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Query: 350 CSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE 409
L+++ R E Q+ + + + + + ++ Q+ N EL + L + +E
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE-KE 1295
Query: 410 ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL--QYRDNSDKTL 467
L ++ + + ++ +++ Q + ++L+H Q + +LL QY + ++
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 468 EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 527
E + +L K + E ++ LEE +K+L Q ++E + +E +
Sbjct: 1356 EL-QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ---RLQEAEEAVEAVNAKC 1411
Query: 528 SSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587
SS E T +++ + ++VE+ + L + + + W+++ E + Q+ L
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE----ESQSEL 1467
Query: 588 HDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV-----LEHE 642
KE LS T L KL E E L + +R+ + LQ+ +SD +Q+ HE
Sbjct: 1468 ESSQKEARSLS-TELFKLKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 643 ME-----IQGLLQSVSTREQESQAAAE----KLVQALMERNSELQALRQYLGGRDSLMSQ 693
+E ++ + + +E++A+ E K+++A +E N + + L +D M Q
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585
Query: 694 APISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEK 753
A ++ + + Q S+ +R + +L K+ + GDL+ +E
Sbjct: 1586 AKRNHLRV---------VDSLQTSLDAETRSRNEALRVKKKME------GDLNE---MEI 1627
Query: 754 ELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKD 813
+LS+A + E+Q ++ +LQS++ + +L + L NI I E
Sbjct: 1628 QLSHAN-------RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1680
Query: 814 LQMQLVDPEDIPAMERLT--------QEVLLLREKVASVESQGQEISGNRRQQLLLMLEG 865
LQ +L E++ A+ T QE++ E+V + SQ + +++ + +
Sbjct: 1681 LQAEL---EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737
Query: 866 LVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSL 925
+ + E AE + ++ E ++++ LE ++ +E+ +
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER---MKKNMEQTIKDLQ 1794
Query: 926 ERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
RL+ E +A GG E E + +E E
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829
Score = 118 bits (296), Expect = 2e-26
Identities = 186/923 (20%), Positives = 402/923 (43%), Gaps = 139/923 (15%)
Query: 12 LNDLKKENFSLKLRIYFLEERMQQKYEASRE-DIYKRNIE--LKVEVESLKRELQDKKQH 68
+N L K L+ ++ LE ++Q+ + + + KR +E LK+ ES+ +L++ KQ
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM-DLENDKQQ 1075
Query: 69 LDKTWADVE------NLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
LD+ + N ++E L Q +++ +E L+ +I+ L+EE +
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKE-------LQARIEELEEELEAERTA 1128
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGD---QVKPDQYTEALAQRDKR----- 174
A++ L +LS +L+ +++ E+ G Q++ ++ EA Q+ +R
Sbjct: 1129 RAKVEKL-------RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1181
Query: 175 ------------------IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTS-----MEV 211
+ EL + + +R+ ++L +EK + L++ TS ++
Sbjct: 1182 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1241
Query: 212 QPMTEELLK--QQKLNSHETTI--TQQSVSD---------SHLAELQEKIQQTEATNKIL 258
+ E++ + + ++N H + TQ+SV+D + EL ++ + EA L
Sbjct: 1242 KANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQL 1301
Query: 259 QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML 318
+ +L+ + +++ L L+S + + L + E + + A+L+ +L
Sbjct: 1302 TRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Query: 319 HQ--SQLGQ---------LHSSEGTSPAQQQVA--LLDLQSALFCSQLEIQKLQRVVRQK 365
+ S++ Q + +E A++++A L + + A+ + L++ +
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 366 ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEK 425
+ ++ D V+ AAA ++++ K E ++ ++ Q EL++ ++ R+ E
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Query: 426 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 485
+ E++++HL + L +E +L + +S KT+ LEK+R+++ +
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE----LEKVRKQLEAEK 1537
Query: 486 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 545
+ L+ A++E ++LE +E ++ + +L + ++E R + +E Q+ + LR
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE--RKLAEKDEEMEQAKRNHLRV-- 1593
Query: 546 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNK---EVEDLSATLL 602
V+ L T+ + + R +K+ E + +++ L N+ E + +L
Sbjct: 1594 --VDSLQTSLD----AETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647
Query: 603 CKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA 662
L Q ++ + + KE + + +R +L+ E+E L++V + + S+
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENI---AIVERRNNLLQAELE---ELRAVVEQTERSRKL 1701
Query: 663 AEKLVQALMERNSELQALRQYLGGRDSLMSQ-----APISNQQAEVTPTGCLGKQTDQGS 717
AE Q L+E + +Q L SL++Q A +S Q EV ++
Sbjct: 1702 AE---QELIETSERVQLLHSQ---NTSLINQKKKMDADLSQLQTEV----------EEAV 1745
Query: 718 MQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE----------KELSNAKEELELMAK 767
+ + ++ + + + DT A LE K+L + +E E +A
Sbjct: 1746 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Query: 768 KERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM 827
K + Q L L++ + E EL+ + + ++ E IK+L Q ED +
Sbjct: 1806 KGGKKQ--LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ--TEEDRKNL 1861
Query: 828 ERLTQEVLLLREKVASVESQGQE 850
RL V L+ KV + + Q +E
Sbjct: 1862 LRLQDLVDKLQLKVKAYKRQAEE 1884
Score = 95.9 bits (237), Expect = 2e-19
Identities = 125/603 (20%), Positives = 258/603 (42%), Gaps = 74/603 (12%)
Query: 30 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEA--EL 87
++++ Q+ + + E + N + +E K LQ++ + L DVE N+ A +
Sbjct: 1390 KKKLAQRLQEAEEAVEAVNAKCS-SLEKTKHRLQNEIEDL---MVDVERSNAAAAALDKK 1445
Query: 88 RRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGV 147
+R F++ E + YE +++++ Q+E+R E ++ E +LE E K
Sbjct: 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE----SLEHLETFKRE 1501
Query: 148 TKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPT 207
KN ++ D TE L K I EL E++ +QL EK +L LEE
Sbjct: 1502 NKNLQEEISD------LTEQLGSSGKTIHEL-------EKVRKQLEAEKMELQSALEEAE 1548
Query: 208 SMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATN-KILQEKLNEMS 266
+ + L Q + N + I ++ LAE E+++Q + + +++ +
Sbjct: 1549 ASLEHEEGKILRAQLEFNQIKAEIERK------LAEKDEEMEQAKRNHLRVVDSLQTSLD 1602
Query: 267 YELKCAQES---SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQL 323
E + E+ +K +G + ++ L R E + ++ L+ +L +Q+
Sbjct: 1603 AETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS-------LQSLLKDTQI 1655
Query: 324 GQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 383
+ ++ +A+++ ++ L Q E+++L+ VV Q ER A+Q +
Sbjct: 1656 QLDDAVRANDDLKENIAIVERRNNLL--QAELEELRAVVEQTERSRKLAEQELIETSERV 1713
Query: 384 HESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL 443
Q + +++ L QLQ E++ Q+ R +E+ + + +
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR----------NAEEKAKKAITDAA 1763
Query: 444 SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS-ALEEK 502
E+L +E +D S LE++++ + L+ +DE AL+
Sbjct: 1764 MMAEELKKE-------QDTSAH--------LERMKKNMEQTIKDLQHRLDEAEQIALKGG 1808
Query: 503 EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK 562
+K+L++L VRE +++LE + + + M+ E ++ + E+ LQ L
Sbjct: 1809 KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1868
Query: 563 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR 622
++++ K ++++ E +Q T+L K +L +++IAE +L+
Sbjct: 1869 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE------AEERADIAESQVNKLRA 1922
Query: 623 KER 625
K R
Sbjct: 1923 KSR 1925
Score = 87.4 bits (215), Expect = 6e-17
Identities = 103/495 (20%), Positives = 218/495 (44%), Gaps = 64/495 (12%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQ------QKYEASREDIYKRNIELKVE 54
+ N Y +HL K+EN +L+ I L E++ + E R+ + +EL+
Sbjct: 1484 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA 1543
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + + + ++ E +L + EE +Q + ++++ L
Sbjct: 1544 LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1603
Query: 115 ESRLAKNEAARMAALVEAE-KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
E+R ++NEA R+ +E + E ++LS + + + V Q L +
Sbjct: 1604 ETR-SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662
Query: 174 RIEELNQSLAAQERLVEQLSREKQQLLHLLEE---PTSMEVQPMTEELLKQQKLNSHETT 230
++L +++A ER L E ++L ++E+ + Q + E + Q L+S T+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 231 -ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
I Q+ D+ L++LQ +++ E E + A+E ++K + E
Sbjct: 1723 LINQKKKMDADLSQLQTEVE--------------EAVQECRNAEEKAKKAITDAAMMAEE 1768
Query: 290 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALF 349
LK + + L ++ + T+ L+ L +++ Q AL
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE----------------------QIALK 1806
Query: 350 CSQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 408
+ ++QKL+ VR+ E +L A+ K+ + V+ + KE +++ +E RK L +LQ
Sbjct: 1807 GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ-TEEDRKNLLRLQ 1865
Query: 409 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE 468
+ + +++A++ R E+ + N +LS +FR++ D +++ +
Sbjct: 1866 DLVDKLQLKVKAYK-------RQAEEAEEQANTNLS-------KFRKVQHELDEAEERAD 1911
Query: 469 ANEMLLEKLRQRIHD 483
E + KLR + D
Sbjct: 1912 IAESQVNKLRAKSRD 1926
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 125 bits (314), Expect = 2e-28
Identities = 209/1055 (19%), Positives = 422/1055 (40%), Gaps = 183/1055 (17%)
Query: 35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEA--ELRRQFE 92
Q+ E + + K + + +++SL+ LQ +KQ ++ + NL +N+ E+ E
Sbjct: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Query: 93 ERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKG-----V 147
+ +Q+ H ++ E+++ + + K + + L + K C EL + V
Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEK---LEQELKRCKSELERSQQAAQSADV 137
Query: 148 TKNWEDVPGD----QVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQL----SREKQQL 199
+ N + P + P QY D + E+ N+ + ++RL ++ +++ Q
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK-EKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 200 L--------HLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK---- 247
L + S V +E ++ + T ++ S S+ + QE
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
Query: 248 -----------------------IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQ 284
+ Q +A N+ L+ K+NE+ L+ ++ + Q Q
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316
Query: 285 NLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDL 344
L+ L+ + E E +V+ D + + Q+ S++ T+ Q+ L L
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQA------STKYTALEQK---LKKL 367
Query: 345 QSALFCSQLEIQK----LQRVVRQKERQLADA------------KQCVQFVEAAAHESEQ 388
L C + + L++ +++KE++ + ++C+Q E +Q
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 389 QKEASWKHNQELRKAL---QQLQEELQNKSQQL----RAWEAE--KYNEIRTQEQNIQHL 439
K EL K QQL+ L+ Q+L +A++A K NE+R + ++
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 440 NHSL-SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 498
N+ L SH EQ +E L N + L ++ E+++ + + L R + EK +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML-RDLQEKINQ 546
Query: 499 LEEKEKELRQLRLAV--------------RERDHDLERLRDVLSSNEATMQSMESLLRAK 544
+E L +L+LAV ++R+H +E+L D LS E +++ S L K
Sbjct: 547 -QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 545 GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCK 604
E E+L +E +T FS W+ E E ++ Q+++ + ++ L L
Sbjct: 606 KKEYEEL-----------KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCL--- 651
Query: 605 LGPGQSEIAEELCQRLQRKE----------RMLQDLLSDRNKQVLEHEMEIQGLLQSVST 654
Q + E +R++ E R L ++L ++ +V ++ L Q
Sbjct: 652 --KTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
Query: 655 REQESQAAAEKLVQALMERNSELQALRQYLG--GRDSLMSQAPISNQQAEVTPTGCLGKQ 712
+Q+ Q E + + +++ L L + + + AE L K
Sbjct: 710 SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 713 TDQGSMQIPSRDDSTSLTA-KEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERE 771
D + + + D SL A + ++ S + + E S + E + K
Sbjct: 770 KD--ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
Query: 772 SQMELSALQSMMAVQEE---ELQVQAADMESLTRNIQIKEDLIKDLQM------------ 816
Q + +L+ + Q++ +LQ Q ++ + +I+E+L+K QM
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG--EIEENLMKAEQMHQSFVAETSQRI 885
Query: 817 ----------QLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 866
Q V E + A+E +E+ LL +KV + +++ QE+ + +LE
Sbjct: 886 SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH-----LLEDS 940
Query: 867 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV-LGRSL 925
+ E L+E L E++ SS++ + E+E L+E+ +
Sbjct: 941 LKELQLLSETLSLEKKEMSSIISLNKR------------EIEELTQENGTLKEINASLNQ 988
Query: 926 ERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
E++N ++ + D+ E + +E +D ++E
Sbjct: 989 EKMNLIQKSESFANYI--DEREKSISELSDQYKQE 1021
Score = 105 bits (262), Expect = 2e-22
Identities = 146/691 (21%), Positives = 310/691 (44%), Gaps = 75/691 (10%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
+++ L + ++EN SLK ++ LE +Q E ++E + K EVE+LK ++++ +
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMS-EENQELVILDAENSKAEVETLKTQIEEMAR 2196
Query: 68 HLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMA 127
L D+ L S+ E L +Q +E+Q + + +LL + LL+E+ E A +
Sbjct: 2197 SLKVFELDLVTLRSEKE-NLTKQIQEKQGQLSELDKLLSSFKSLLEEK------EQAEIQ 2249
Query: 128 ALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQER 187
E++ + L +LK + + + GDQ ++L D IEE +Q + E+
Sbjct: 2250 IKEESKTAVEM-LQNQLKELNEAVAALCGDQEIMKATEQSL---DPPIEEEHQLRNSIEK 2305
Query: 188 LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK 247
L +L ++++ L +L++ E +LLK ++ + E + + H A +
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHH---ADLLK-GRVENLERELEIARTNQEHAA---LE 2358
Query: 248 IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQ 307
+ ++ + L+ K+ M+ L+ + TI++ KE L + ++ +E +E
Sbjct: 2359 AENSKGEVETLKAKIEGMTQSLR----GLELDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 308 NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKER 367
N + + + Q ++ Q+ T+ Q L +L + + Q + KE+
Sbjct: 2415 NSSFENILQEKEQEKV-QMKEKSSTAMEMLQTQLKELNERV----AALHNDQEACKAKEQ 2469
Query: 368 QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYN 427
L+ +C++ +A + + + ++ L+ ++ L +E+++ Q+L
Sbjct: 2470 NLSSQVECLELEKAQLLQGLDEAKNNY---IVLQSSVNGLIQEVEDGKQKL--------- 2517
Query: 428 EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVA 487
+++ I L + + +EQL+ + + +E L ++ + + V
Sbjct: 2518 --EKKDEEISRLKNQIQDQEQLVSKLSQ-----------VEGEHQLWKEQNLELRNLTVE 2564
Query: 488 LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
LE +K L+ K L+ ++ +LE ++ ++ + + + AK E
Sbjct: 2565 LE----QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
Query: 548 VE-QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTS---LHDRNKEVEDLSATLLC 603
++ ++ Q L+EE+ + +R E + +++++++S L + E +L +L C
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
Query: 604 -------KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTRE 656
K G + EIAE RL E+ Q LL D NKQ +E+EIQ + ++++E
Sbjct: 2681 MHKDQVEKEGKVREEIAEYQL-RLHEAEKKHQALLLDTNKQ---YEVEIQTYREKLTSKE 2736
Query: 657 Q---ESQAAAEKLVQALMERNSELQALRQYL 684
+ + + L + E N+ L+A Q L
Sbjct: 2737 ECLSSQKLEIDLLKSSKEELNNSLKATTQIL 2767
Score = 99.4 bits (246), Expect = 1e-20
Identities = 207/1000 (20%), Positives = 416/1000 (41%), Gaps = 158/1000 (15%)
Query: 15 LKKENFSLKLRIYFLEERM------QQKYEASREDIYKRNIELKVEVESLKRELQDKKQH 68
L+K+N + + I LEE + + + + + K+ L + L ++++K Q
Sbjct: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL----DQLSEKMKEKTQE 1990
Query: 69 LDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLEN------KIQLLQEESR---LA 119
L+ ++ + EAE++ + E Q + V ELL++ K+Q L+++S+ L
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 120 KNEAARMAALVEAEKECNLELSEKLK-----------GVTKNWEDVPGDQVKPDQYTEAL 168
K E A + EKE ++ SE L+ V+K E V+ ++ L
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE---AALVEKGEFALRL 2107
Query: 169 AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSME---------VQPMTEELL 219
+ + + +L + + E+L ++ ++++ LH+ E+ E V+ + EL
Sbjct: 2108 SSTQEEVHQLRRGI---EKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL- 2163
Query: 220 KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 279
Q + E I S + + L+ +I++ + K+ + L + E + + Q++
Sbjct: 2164 -QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222
Query: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQV 339
G + L + L S + EE Q E Q +K + Q+QL +L+ + Q++
Sbjct: 2223 QGQLSELDKLLSSFKSLLEEKEQA-EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEI 2281
Query: 340 ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQ--CV-QFVEAAAHESEQQKEASWKH 396
QS + E Q + + + R AD K+ CV Q ++ + H ++ K
Sbjct: 2282 MKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENL 2341
Query: 397 NQELRKA-----------------LQQLQEELQNKSQQLRAWE-------AEK---YNEI 429
+EL A ++ L+ +++ +Q LR E +EK NE+
Sbjct: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL 2401
Query: 430 RTQEQNIQHLNHSLSHKEQLLQE-FRELLQYRDNSDKTLEANEMLLEKLRQRI---HDKA 485
+ +++ I L S E +LQE +E +Q ++ S +E + L++L +R+ H+
Sbjct: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 486 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 545
A + S +E E E QL + E ++ L+ ++ ++ + L K
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 546 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 605
E+ +L Q+ +E++ +K S+ + E + +Q N E+ +L+ L
Sbjct: 2522 EEISRLKNQIQD----QEQLVSKLSQVEGEHQLWKEQ--------NLELRNLTVEL---- 2565
Query: 606 GPGQSEIAEELCQRLQRKERMLQDLLS--DRNKQVLEHEMEIQGL--------LQSVSTR 655
E+ Q LQ K LQD L + + LE+E+E+ + + ++ +
Sbjct: 2566 --------EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Query: 656 EQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPIS--NQQAEVT--------P 705
E E Q ++ Q E EL + L G L+ + S +Q E+T
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 706 TGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELM 765
C+ K DQ + R++ + + + LDT E E+ +E+L
Sbjct: 2678 LDCMHK--DQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 766 AKKERESQMELSALQSMMAVQEEELQVQAADMESLTR----NIQIKEDLIKDLQ-----M 816
+ ++E+ L+S L+ +E L + N++ L K+ + M
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
Query: 817 QLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS----R 872
+L+ I + ++L +E +L+++++ ++ + +Q+ +++ VDE +
Sbjct: 2796 KLL----IKSCKQLEEEKEILQKELSQLQ------AAQEKQKTGTVMDTKVDELTTEIKE 2845
Query: 873 LNEALQAERQ-------LYSSLVKFHAHPESSERDRTLQV 905
L E L+ + + Y SL+ H E ++ QV
Sbjct: 2846 LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 99.0 bits (245), Expect = 2e-20
Identities = 199/995 (20%), Positives = 411/995 (41%), Gaps = 136/995 (13%)
Query: 12 LNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIE-LKVEVESLKRELQDKKQHLD 70
L ++ E +L+ +I LE ++ + S E Y + L+++ E+L E+++ LD
Sbjct: 630 LTQMESEKENLQSKINHLETCLKTQQIKSHE--YNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 71 KTWADVEN-----LNSQNEAELRRQFEERQ---------------QETEHVYELLENKIQ 110
+VE + Q +AE Q +++ ++ EH +LL N+I
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 111 --------LLQEESRLAKNEAARMAALVEAEK-ECNLELSEKLKGVTKNWEDVPGDQ--- 158
L E L ++ A+LV E + +L ++ + ++ ++ G+Q
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSM 807
Query: 159 --------VKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEE--PTS 208
++ DQ + A R++ L SL +Q+++ L ++ ++L+ + E
Sbjct: 808 PSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL 867
Query: 209 MEVQPMTEELLKQ--QKLNS-HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEM 265
M+ + M + + + Q+++ E T Q+V L+ L+ K ++ + N ++ + E+
Sbjct: 868 MKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI 927
Query: 266 SYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQV-------IEGQNDTMAKLREML 318
ELK + + +Q L ETL ++E + + + +N T+ ++ L
Sbjct: 928 Q-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
Query: 319 HQSQLGQLHSSEGTSP----------------AQQQVALLDLQSALFCSQLEIQKLQRVV 362
+Q ++ + SE + Q+++ LL + ++ + +
Sbjct: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
Query: 363 RQKERQLADA-KQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAW 421
++K +L +C E +E EQ KEA K +QE L +E QN +L
Sbjct: 1047 QEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETV 1106
Query: 422 EAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRI 481
+ +E+ + N + L + L+E + +Q N L+ NE L++ ++ +
Sbjct: 1107 QQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND--LLQENEQLMKVMKTKH 1164
Query: 482 HDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 541
+ + E ++++E+E E Q + DLE L S A + +E++L
Sbjct: 1165 ECQNLESEPI----RNSVKERESERNQCNF---KPQMDLEVKEISLDSYNAQLVQLEAML 1217
Query: 542 RAKGLEVEQLSTTCQ----NLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDL 597
R K L++++ + LQ ++ ++ET + + QE + L D + E+
Sbjct: 1218 RNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEI------SGLKDCEIDAEEK 1271
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
+ +L Q++ A C LQ L +L ++ ++L+ E L+ ++
Sbjct: 1272 YISGPHELSTSQNDNAHLQCS-LQTTMNKLNEL--EKICEILQAEK--YELVTELNDSRS 1326
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQ-TDQG 716
E A K+ + + + +E++ L G + + E P G G+Q +Q
Sbjct: 1327 ECITATRKMAEEVGKLLNEVKILNDDSG---------LLHGELVEDIPGGEFGEQPNEQH 1377
Query: 717 SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT---VAGLEKELSNAKEELELMAKKERESQ 773
+ + D+S S TL D + A L+++ + + E +++ + +
Sbjct: 1378 PVSLAPLDESN--------SYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS 1429
Query: 774 MELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQE 833
++S LQ+ + + L+ + + + RN Q DL+K++Q+ L + +P+
Sbjct: 1430 SKMSELQTYV----DSLKAENLVLSTNLRNFQ--GDLVKEMQLGL-EEGLVPS------- 1475
Query: 834 VLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAH 893
L S + + + LL G + S L A+ A + +
Sbjct: 1476 ---LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQ 1532
Query: 894 PESSERDRTLQVELEGAQVLRSRLEEVLGRSLERL 928
E+ R T +G + L S L EV +SLE+L
Sbjct: 1533 EENLTRKETPSAPAKGVEELES-LCEVYRQSLEKL 1566
Score = 75.5 bits (184), Expect = 2e-13
Identities = 189/908 (20%), Positives = 345/908 (37%), Gaps = 163/908 (17%)
Query: 3 NGYRTLSQHLNDLKKENFSLKLRIY---FLEERMQQKYEASREDIYKRNIELKVEV---- 55
N Y LSQ +++N L+ + L E + + E +E K + E ++
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 56 ---ESLKRELQDKKQHLDKTWADVENLNSQNEA-----ELRRQFEERQQETEHVYELLEN 107
++L EL+ +Q L D +N NS++EA E+ EE+ + + V +LL+
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQN-NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
Query: 108 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEA 167
QL++ + + + + KE SE+ + K D+ ++ D Y
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVKERE---SERNQCNFKPQMDLEVKEISLDSYNAQ 1209
Query: 168 LAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSH 227
L Q + + L E+ E L E Q + LE ++Q LK ++++
Sbjct: 1210 LVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAE 1269
Query: 228 ETTIT---QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES-----SQKQ 279
E I+ + S S + A LQ +Q T KLNE+ + Q ++
Sbjct: 1270 EKYISGPHELSTSQNDNAHLQCSLQTT-------MNKLNELEKICEILQAEKYELVTELN 1322
Query: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSE-GTSPAQQQ 338
D + + T K E E +L ++ ND +LH + + E G P +Q
Sbjct: 1323 DSRSECITATRKMAE-EVGKLLNEVKILNDDSG----LLHGELVEDIPGGEFGEQPNEQH 1377
Query: 339 -VALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397
V+L L + L + + V+ +L + +Q H+ Q +
Sbjct: 1378 PVSLAPLDESNSYEHLTLS--DKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS-- 1433
Query: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRT--QEQNIQHLNHSLSHKEQLLQEFRE 455
EL+ + L+ E S LR ++ + E++ +E + L+ S L +
Sbjct: 1434 -ELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGD 1492
Query: 456 LLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKF-SALEEKEKELRQLRLAVR 514
YR ++T + + L + A + ++DE F S+L+E+ ++ A
Sbjct: 1493 SSFYRALLEQTGDMS------LLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAP- 1545
Query: 515 ERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC----QNLQWLKEEMETKFS 570
AKG VE+L + C Q+L+ L+E+ME++
Sbjct: 1546 ----------------------------AKG--VEELESLCEVYRQSLEKLEEKMESQGI 1575
Query: 571 RWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI-----------------A 613
KE IQ+L+ L +E++ L L + Q ++
Sbjct: 1576 MKNKE----IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQT 1631
Query: 614 EELCQRLQRKERMLQDL-LSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
E+L L+ LQ L LS R+ ++ E IQG +S ++ + E+ + +
Sbjct: 1632 EQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691
Query: 673 RNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG-CLGKQTDQGSMQIPSRDDSTSLT- 730
+ + A + L + V PTG C G+Q+ + + P D + +
Sbjct: 1692 QICDKDA-------QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSE 1744
Query: 731 -------AKEDVSIPRSTLGDLDTVAGLE---KELSN-------------AKEELELMAK 767
+ + +P LG+ + + L+ KE SN K E L
Sbjct: 1745 CISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM 1804
Query: 768 KERESQMELSALQSMMAVQ-------------------EEELQVQAADMESLTRNIQIKE 808
KE +S++ L +Q M ++ E+L+ + D + L + ++ E
Sbjct: 1805 KELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSE 1864
Query: 809 DLIKDLQM 816
L DL+M
Sbjct: 1865 GLNSDLEM 1872
Score = 73.6 bits (179), Expect = 9e-13
Identities = 145/712 (20%), Positives = 279/712 (39%), Gaps = 79/712 (11%)
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
+KIQ+ E L+++ + ++L + + QKQ ++N K + +RE + L ++ E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQK 365
T K+ L Q + Q++ EG L + +I+KL++ +++
Sbjct: 78 SLEKTKQKISHEL-QVKESQVNFQEG---------------QLNSGKKQIEKLEQELKRC 121
Query: 366 ERQLADAKQCVQFVEAAAHESEQQKEA-----------SWKHNQELRKALQQLQEELQNK 414
+ +L ++Q Q + + + ++ S ++L++ + EE +
Sbjct: 122 KSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRL 181
Query: 415 SQQLRAWEAEKYNEIRTQEQNIQH---LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANE 471
+++A +A+K ++ Q + H H S Q+ + NS +T
Sbjct: 182 EAEVKALQAKKASQTLPQ-ATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT----- 235
Query: 472 MLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNE 531
+R+ + E+ + S L+ +++ H L++L+
Sbjct: 236 ----PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
Query: 532 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRN 591
+ +E L+ E++ Q LQ E+ + + E+E ++ + + L R
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI----EKEKVLNKCRDEL-VRT 346
Query: 592 KEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS 651
D ++T L ++ E+L + Q E L ++ E + E+ +S
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 652 VSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK 711
T +QE +L Q L + + L+ L S+ Q + N E C +
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ--LENNLEEFKQKLCRAE 464
Query: 712 QTDQGSMQIPSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKELSNAKEEL------- 762
Q Q S QI + S+ KE+ + + V LE EL N K+ L
Sbjct: 465 QAFQAS-QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 763 ELMAKKERESQMELSALQSMMAVQE-----EELQVQAADMESLTRNIQIKEDLIKDLQMQ 817
E M K + L LQ + QE E+L++ AD+E + +DL+K +
Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE---KQRDCSQDLLKKREHH 580
Query: 818 LVDPEDIPAMERLTQEVLL--LREKVASVESQGQEIS-----GNRRQQLLLMLEGLVDE- 869
+ D + + LL L K E +E + + ++LL +E +
Sbjct: 581 IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL 640
Query: 870 RSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 921
+S++N E L + +K H E +ER RTL+++ E V L VL
Sbjct: 641 QSKIN---HLETCLKTQQIKSH---EYNERVRTLEMDRENLSVEIRNLHNVL 686
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.320
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,479,353
Number of Sequences: 37866
Number of extensions: 1392647
Number of successful extensions: 24031
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 429
Number of HSP's successfully gapped in prelim test: 1309
Number of HSP's that attempted gapping in prelim test: 8426
Number of HSP's gapped (non-prelim): 7154
length of query: 969
length of database: 18,247,518
effective HSP length: 112
effective length of query: 857
effective length of database: 14,006,526
effective search space: 12003592782
effective search space used: 12003592782
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.