Search of human proteins with 5032283

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Search of human proteins with 5032283

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
         (3685 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                  7293   0.0  
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                  7266   0.0  
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                 7266   0.0  
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]                 7041   0.0  
gi|5032285 dystrophin Dp427l isoform [Homo sapiens]                  7041   0.0  
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]                 4598   0.0  
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]               4597   0.0  
gi|5032293 dystrophin Dp140 isoform [Homo sapiens]                   2452   0.0  
gi|5032309 dystrophin Dp140b isoform [Homo sapiens]                  2427   0.0  
gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]                 2390   0.0  
gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]                 1908   0.0  
gi|5032295 dystrophin Dp116 isoform [Homo sapiens]                   1907   0.0  
gi|5032307 dystrophin Dp140c isoform [Homo sapiens]                  1888   0.0  
gi|110611228 utrophin [Homo sapiens]                                 1740   0.0  
gi|5032297 dystrophin Dp71 isoform [Homo sapiens]                    1240   0.0  
gi|5032299 dystrophin Dp71b isoform [Homo sapiens]                   1214   0.0  
gi|5032301 dystrophin Dp71a isoform [Homo sapiens]                   1203   0.0  
gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]                  1177   0.0  
gi|148539558 dystrophin related protein 2 [Homo sapiens]              996   0.0  
gi|5032305 dystrophin Dp40 isoform [Homo sapiens]                     693   0.0  
gi|33188443 microfilament and actin filament cross-linker protei...   370   e-101
gi|33188445 microfilament and actin filament cross-linker protei...   370   e-101
gi|221316624 dystonin isoform 4 [Homo sapiens]                        325   7e-88
gi|221316622 dystonin isoform 3 [Homo sapiens]                        325   7e-88
gi|221316618 dystonin isoform 2 [Homo sapiens]                        325   7e-88
gi|34577047 dystonin isoform 1 [Homo sapiens]                         325   7e-88
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             325   7e-88
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...   318   6e-86
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...   311   8e-84
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          299   4e-80

>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
          Length = 3685

 Score = 7293 bits (18923), Expect = 0.0
 Identities = 3685/3685 (100%), Positives = 3685/3685 (100%)

Query: 1    MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQ 60
            MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQ
Sbjct: 1    MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQ 60

Query: 61   KLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQV 120
            KLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQV
Sbjct: 61   KLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQV 120

Query: 121  KNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL 180
            KNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
Sbjct: 121  KNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL 180

Query: 181  FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLP 240
            FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLP
Sbjct: 181  FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLP 240

Query: 241  QQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA 300
            QQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA
Sbjct: 241  QQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA 300

Query: 301  YTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED 360
            YTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
Sbjct: 301  YTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED 360

Query: 361  TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEV 420
            TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEV
Sbjct: 361  TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEV 420

Query: 421  QEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLG 480
            QEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLG
Sbjct: 421  QEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLG 480

Query: 481  PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW 540
            PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
Sbjct: 481  PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW 540

Query: 541  ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL 600
            ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL
Sbjct: 541  ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL 600

Query: 601  QKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEK 660
            QKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEK
Sbjct: 601  QKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEK 660

Query: 661  STAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI 720
            STAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
Sbjct: 661  STAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI 720

Query: 721  RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA 780
            RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA
Sbjct: 721  RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA 780

Query: 781  SRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQ 840
            SRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQ
Sbjct: 781  SRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQ 840

Query: 841  QLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK 900
            QLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK
Sbjct: 841  QLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK 900

Query: 901  GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 960
            GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET
Sbjct: 901  GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 960

Query: 961  KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1020
            KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS
Sbjct: 961  KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1020

Query: 1021 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1080
            EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD
Sbjct: 1021 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1080

Query: 1081 SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDH 1140
            SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDH
Sbjct: 1081 SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDH 1140

Query: 1141 MCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEM 1200
            MCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEM
Sbjct: 1141 MCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEM 1200

Query: 1201 KRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKT 1260
            KRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKT
Sbjct: 1201 KRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKT 1260

Query: 1261 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNP 1320
            LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNP
Sbjct: 1261 LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNP 1320

Query: 1321 NQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLH 1380
            NQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLH
Sbjct: 1321 NQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLH 1380

Query: 1381 LIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440
            LIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV
Sbjct: 1381 LIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440

Query: 1441 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1500
            LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS
Sbjct: 1441 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1500

Query: 1501 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1560
            QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT
Sbjct: 1501 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1560

Query: 1561 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE 1620
            ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE
Sbjct: 1561 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE 1620

Query: 1621 IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKH 1680
            IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKH
Sbjct: 1621 IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKH 1680

Query: 1681 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 1740
            METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN
Sbjct: 1681 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 1740

Query: 1741 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 1800
            LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE
Sbjct: 1741 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 1800

Query: 1801 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNA 1860
            IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNA
Sbjct: 1801 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNA 1860

Query: 1861 LKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQ 1920
            LKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQ
Sbjct: 1861 LKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQ 1920

Query: 1921 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
            KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE
Sbjct: 1921 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980

Query: 1981 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2040
            TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN
Sbjct: 1981 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2040

Query: 2041 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
            IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD
Sbjct: 2041 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100

Query: 2101 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVR 2160
            RSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVR
Sbjct: 2101 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVR 2160

Query: 2161 TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDL 2220
            TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDL
Sbjct: 2161 TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDL 2220

Query: 2221 NEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2280
            NEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS
Sbjct: 2221 NEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2280

Query: 2281 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2340
            APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL
Sbjct: 2281 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2340

Query: 2341 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2400
            LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK
Sbjct: 2341 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2400

Query: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
            RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE
Sbjct: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880

Query: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940

Query: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000

Query: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060

Query: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120

Query: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180

Query: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240

Query: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300

Query: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360

Query: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3420
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3420

Query: 3421 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3480
            APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 3421 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3480

Query: 3481 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3540
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 3481 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3540

Query: 3541 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3600
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 3541 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3600

Query: 3601 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3660
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 3601 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3660

Query: 3661 EQLNNSFPSSRGRNTPGKPMREDTM 3685
            EQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3661 EQLNNSFPSSRGRNTPGKPMREDTM 3685


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score = 7266 bits (18851), Expect = 0.0
 Identities = 3674/3674 (100%), Positives = 3674/3674 (100%)

Query: 12   EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
            EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV
Sbjct: 4    EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 63

Query: 72   HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
            HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL
Sbjct: 64   HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 123

Query: 132  QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
            QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS
Sbjct: 124  QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 183

Query: 192  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 251
            ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV
Sbjct: 184  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 243

Query: 252  EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 311
            EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD
Sbjct: 244  EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 303

Query: 312  PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 371
            PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND
Sbjct: 304  PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 363

Query: 372  VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 431
            VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW
Sbjct: 364  VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 423

Query: 432  ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 491
            ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ
Sbjct: 424  ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 483

Query: 492  QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 551
            QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW
Sbjct: 484  QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 543

Query: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
            VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE
Sbjct: 544  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 603

Query: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
            KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT
Sbjct: 604  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 663

Query: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
            TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL
Sbjct: 664  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 723

Query: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
            HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM
Sbjct: 724  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 783

Query: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851
            VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN
Sbjct: 784  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 843

Query: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
            WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF
Sbjct: 844  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 903

Query: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971
            VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD
Sbjct: 904  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 963

Query: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
            YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK
Sbjct: 964  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1023

Query: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
            LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC
Sbjct: 1024 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1083

Query: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
            RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA
Sbjct: 1084 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143

Query: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
            LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203

Query: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271
            AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL
Sbjct: 1204 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1263

Query: 1272 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1331
            LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT
Sbjct: 1264 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1323

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
            DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK
Sbjct: 1324 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1383

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1451
            QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL
Sbjct: 1384 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1443

Query: 1452 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1511
            QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS
Sbjct: 1444 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1503

Query: 1512 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1571
            LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK
Sbjct: 1504 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1563

Query: 1572 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1631
            LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI
Sbjct: 1564 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1623

Query: 1632 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1691
            TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI
Sbjct: 1624 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1683

Query: 1692 TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1751
            TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK
Sbjct: 1684 TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1743

Query: 1752 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1811
            LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED
Sbjct: 1744 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1803

Query: 1812 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1871
            FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK
Sbjct: 1804 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1863

Query: 1872 ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR 1931
            ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR
Sbjct: 1864 ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR 1923

Query: 1932 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL 1991
            QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL
Sbjct: 1924 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL 1983

Query: 1992 EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2051
            EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR
Sbjct: 1984 EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2043

Query: 2052 IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 2111
            IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY
Sbjct: 2044 IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 2103

Query: 2112 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
            DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ
Sbjct: 2104 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2163

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
            QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD
Sbjct: 2164 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2223

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
            NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL
Sbjct: 2224 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2283

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL
Sbjct: 2284 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2343

Query: 2352 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2411
            EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK
Sbjct: 2344 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2403

Query: 2412 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471
            AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA
Sbjct: 2404 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2463

Query: 2472 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2531
            LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI
Sbjct: 2464 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2523

Query: 2532 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2591
            TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE
Sbjct: 2524 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2583

Query: 2592 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2651
            AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY
Sbjct: 2584 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2643

Query: 2652 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
            SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT
Sbjct: 2644 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2703

Query: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
            ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2763

Query: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
            AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2823

Query: 2832 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2891
            APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL
Sbjct: 2824 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2883

Query: 2892 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2951
            PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR
Sbjct: 2884 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2943

Query: 2952 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3011
            QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP
Sbjct: 2944 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3003

Query: 3012 YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP 3071
            YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP
Sbjct: 3004 YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP 3063

Query: 3072 YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD 3131
            YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD
Sbjct: 3064 YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD 3123

Query: 3132 ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT 3191
            ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT
Sbjct: 3124 ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT 3183

Query: 3192 GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV 3251
            GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV
Sbjct: 3184 GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV 3243

Query: 3252 ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA 3311
            ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA
Sbjct: 3244 ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA 3303

Query: 3312 KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD 3371
            KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD
Sbjct: 3304 KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD 3363

Query: 3372 FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD 3431
            FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD
Sbjct: 3364 FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD 3423

Query: 3432 DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP 3491
            DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP
Sbjct: 3424 DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP 3483

Query: 3492 AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ 3551
            AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ
Sbjct: 3484 AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ 3543

Query: 3552 SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV 3611
            SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV
Sbjct: 3544 SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV 3603

Query: 3612 SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3671
            SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR
Sbjct: 3604 SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3663

Query: 3672 GRNTPGKPMREDTM 3685
            GRNTPGKPMREDTM
Sbjct: 3664 GRNTPGKPMREDTM 3677


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score = 7266 bits (18851), Expect = 0.0
 Identities = 3674/3674 (100%), Positives = 3674/3674 (100%)

Query: 12   EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
            EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV
Sbjct: 8    EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 67

Query: 72   HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
            HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL
Sbjct: 68   HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 127

Query: 132  QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
            QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS
Sbjct: 128  QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 187

Query: 192  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 251
            ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV
Sbjct: 188  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 247

Query: 252  EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 311
            EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD
Sbjct: 248  EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 307

Query: 312  PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 371
            PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND
Sbjct: 308  PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 367

Query: 372  VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 431
            VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW
Sbjct: 368  VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 427

Query: 432  ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 491
            ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ
Sbjct: 428  ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 487

Query: 492  QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 551
            QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW
Sbjct: 488  QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 547

Query: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
            VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE
Sbjct: 548  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 607

Query: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
            KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT
Sbjct: 608  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667

Query: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
            TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL
Sbjct: 668  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727

Query: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
            HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM
Sbjct: 728  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787

Query: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851
            VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN
Sbjct: 788  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 847

Query: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
            WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF
Sbjct: 848  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907

Query: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971
            VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD
Sbjct: 908  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 967

Query: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
            YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK
Sbjct: 968  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1027

Query: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
            LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC
Sbjct: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1087

Query: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
            RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA
Sbjct: 1088 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147

Query: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
            LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207

Query: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271
            AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL
Sbjct: 1208 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1267

Query: 1272 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1331
            LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT
Sbjct: 1268 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1327

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
            DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK
Sbjct: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1451
            QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL
Sbjct: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1447

Query: 1452 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1511
            QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS
Sbjct: 1448 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1507

Query: 1512 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1571
            LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK
Sbjct: 1508 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1567

Query: 1572 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1631
            LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI
Sbjct: 1568 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1627

Query: 1632 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1691
            TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI
Sbjct: 1628 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1687

Query: 1692 TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1751
            TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK
Sbjct: 1688 TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1747

Query: 1752 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1811
            LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED
Sbjct: 1748 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1807

Query: 1812 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1871
            FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK
Sbjct: 1808 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1867

Query: 1872 ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR 1931
            ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR
Sbjct: 1868 ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR 1927

Query: 1932 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL 1991
            QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL
Sbjct: 1928 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL 1987

Query: 1992 EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2051
            EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR
Sbjct: 1988 EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2047

Query: 2052 IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 2111
            IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY
Sbjct: 2048 IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 2107

Query: 2112 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
            DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ
Sbjct: 2108 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
            QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD
Sbjct: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
            NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL
Sbjct: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL
Sbjct: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347

Query: 2352 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2411
            EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK
Sbjct: 2348 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2407

Query: 2412 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471
            AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA
Sbjct: 2408 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2467

Query: 2472 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2531
            LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI
Sbjct: 2468 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2527

Query: 2532 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2591
            TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE
Sbjct: 2528 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2587

Query: 2592 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2651
            AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY
Sbjct: 2588 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2647

Query: 2652 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
            SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT
Sbjct: 2648 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707

Query: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
            ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767

Query: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
            AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827

Query: 2832 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2891
            APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL
Sbjct: 2828 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2887

Query: 2892 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2951
            PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR
Sbjct: 2888 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2947

Query: 2952 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3011
            QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP
Sbjct: 2948 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3007

Query: 3012 YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP 3071
            YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP
Sbjct: 3008 YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP 3067

Query: 3072 YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD 3131
            YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD
Sbjct: 3068 YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD 3127

Query: 3132 ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT 3191
            ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT
Sbjct: 3128 ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT 3187

Query: 3192 GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV 3251
            GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV
Sbjct: 3188 GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV 3247

Query: 3252 ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA 3311
            ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA
Sbjct: 3248 ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA 3307

Query: 3312 KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD 3371
            KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD
Sbjct: 3308 KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD 3367

Query: 3372 FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD 3431
            FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD
Sbjct: 3368 FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD 3427

Query: 3432 DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP 3491
            DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP
Sbjct: 3428 DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP 3487

Query: 3492 AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ 3551
            AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ
Sbjct: 3488 AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ 3547

Query: 3552 SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV 3611
            SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV
Sbjct: 3548 SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV 3607

Query: 3612 SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3671
            SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR
Sbjct: 3608 SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3667

Query: 3672 GRNTPGKPMREDTM 3685
            GRNTPGKPMREDTM
Sbjct: 3668 GRNTPGKPMREDTM 3681


>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
          Length = 3562

 Score = 7041 bits (18267), Expect = 0.0
 Identities = 3562/3562 (100%), Positives = 3562/3562 (100%)

Query: 124  MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 183
            MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW
Sbjct: 1    MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 60

Query: 184  NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 243
            NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV
Sbjct: 61   NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 120

Query: 244  SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 303
            SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ
Sbjct: 121  SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 180

Query: 304  AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 363
            AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ
Sbjct: 181  AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 240

Query: 364  AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 423
            AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ
Sbjct: 241  AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 300

Query: 424  MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 483
            MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL
Sbjct: 301  MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 360

Query: 484  EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 543
            EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI
Sbjct: 361  EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 420

Query: 544  CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 603
            CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL
Sbjct: 421  CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 480

Query: 604  AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 663
            AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA
Sbjct: 481  AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 540

Query: 664  QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723
            QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR
Sbjct: 541  QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600

Query: 724  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 783
            LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS
Sbjct: 601  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660

Query: 784  AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 843
            AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE
Sbjct: 661  AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720

Query: 844  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 903
            QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG
Sbjct: 721  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780

Query: 904  PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 963
            PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS
Sbjct: 781  PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 840

Query: 964  IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 1023
            IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE
Sbjct: 841  IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 900

Query: 1024 EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 1083
            EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI
Sbjct: 901  EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 960

Query: 1084 LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1143
            LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ
Sbjct: 961  LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020

Query: 1144 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1203
            QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080

Query: 1204 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
            KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1140

Query: 1264 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1323
            VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI
Sbjct: 1141 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200

Query: 1324 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1383
            RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ
Sbjct: 1201 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1260

Query: 1384 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1443
            ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
Sbjct: 1261 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1320

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
            IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380

Query: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563
            HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440

Query: 1564 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623
            QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500

Query: 1624 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1683
            QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1560

Query: 1684 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA
Sbjct: 1561 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1620

Query: 1744 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1803
            NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ
Sbjct: 1621 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1680

Query: 1804 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1863
            GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD
Sbjct: 1681 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1740

Query: 1864 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1923
            LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK
Sbjct: 1741 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1800

Query: 1924 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
            EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860

Query: 1984 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2043
            VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920

Query: 2044 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2103
            SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 1980

Query: 2104 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2163
            EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN
Sbjct: 1981 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2040

Query: 2164 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2223
            ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF
Sbjct: 2041 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2100

Query: 2224 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2283
            VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI
Sbjct: 2101 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2160

Query: 2284 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2343
            SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW
Sbjct: 2161 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2220

Query: 2344 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2403
            LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL
Sbjct: 2221 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2280

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
            RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2643
            QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2520

Query: 2644 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2703
            ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA
Sbjct: 2521 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2580

Query: 2704 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2763
            WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL
Sbjct: 2581 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2640

Query: 2764 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2823
            RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL
Sbjct: 2641 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2700

Query: 2824 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2883
            KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK
Sbjct: 2701 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2760

Query: 2884 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2943
            LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT
Sbjct: 2761 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2820

Query: 2944 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 3003
            DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT
Sbjct: 2821 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 2880

Query: 3004 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 3063
            TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER
Sbjct: 2881 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 2940

Query: 3064 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3123
            AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL
Sbjct: 2941 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3000

Query: 3124 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3183
            LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
Sbjct: 3001 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3060

Query: 3184 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3243
            NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ
Sbjct: 3061 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3120

Query: 3244 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3303
            IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA
Sbjct: 3121 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3180

Query: 3304 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3363
            AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT
Sbjct: 3181 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3240

Query: 3364 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3423
            TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA
Sbjct: 3241 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3300

Query: 3424 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3483
            SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS
Sbjct: 3301 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3360

Query: 3484 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3543
            PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP
Sbjct: 3361 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3420

Query: 3544 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3603
            EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE
Sbjct: 3421 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3480

Query: 3604 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3663
            AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL
Sbjct: 3481 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3540

Query: 3664 NNSFPSSRGRNTPGKPMREDTM 3685
            NNSFPSSRGRNTPGKPMREDTM
Sbjct: 3541 NNSFPSSRGRNTPGKPMREDTM 3562


>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
          Length = 3562

 Score = 7041 bits (18267), Expect = 0.0
 Identities = 3562/3562 (100%), Positives = 3562/3562 (100%)

Query: 124  MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 183
            MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW
Sbjct: 1    MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 60

Query: 184  NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 243
            NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV
Sbjct: 61   NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 120

Query: 244  SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 303
            SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ
Sbjct: 121  SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 180

Query: 304  AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 363
            AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ
Sbjct: 181  AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 240

Query: 364  AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 423
            AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ
Sbjct: 241  AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 300

Query: 424  MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 483
            MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL
Sbjct: 301  MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 360

Query: 484  EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 543
            EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI
Sbjct: 361  EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 420

Query: 544  CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 603
            CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL
Sbjct: 421  CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 480

Query: 604  AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 663
            AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA
Sbjct: 481  AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 540

Query: 664  QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723
            QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR
Sbjct: 541  QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600

Query: 724  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 783
            LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS
Sbjct: 601  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660

Query: 784  AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 843
            AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE
Sbjct: 661  AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720

Query: 844  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 903
            QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG
Sbjct: 721  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780

Query: 904  PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 963
            PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS
Sbjct: 781  PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 840

Query: 964  IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 1023
            IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE
Sbjct: 841  IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 900

Query: 1024 EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 1083
            EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI
Sbjct: 901  EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 960

Query: 1084 LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1143
            LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ
Sbjct: 961  LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020

Query: 1144 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1203
            QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080

Query: 1204 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
            KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1140

Query: 1264 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1323
            VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI
Sbjct: 1141 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200

Query: 1324 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1383
            RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ
Sbjct: 1201 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1260

Query: 1384 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1443
            ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
Sbjct: 1261 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1320

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
            IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380

Query: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563
            HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440

Query: 1564 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623
            QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500

Query: 1624 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1683
            QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1560

Query: 1684 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA
Sbjct: 1561 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1620

Query: 1744 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1803
            NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ
Sbjct: 1621 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1680

Query: 1804 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1863
            GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD
Sbjct: 1681 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1740

Query: 1864 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1923
            LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK
Sbjct: 1741 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1800

Query: 1924 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
            EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860

Query: 1984 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2043
            VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920

Query: 2044 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2103
            SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 1980

Query: 2104 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2163
            EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN
Sbjct: 1981 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2040

Query: 2164 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2223
            ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF
Sbjct: 2041 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2100

Query: 2224 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2283
            VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI
Sbjct: 2101 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2160

Query: 2284 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2343
            SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW
Sbjct: 2161 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2220

Query: 2344 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2403
            LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL
Sbjct: 2221 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2280

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
            RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2643
            QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2520

Query: 2644 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2703
            ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA
Sbjct: 2521 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2580

Query: 2704 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2763
            WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL
Sbjct: 2581 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2640

Query: 2764 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2823
            RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL
Sbjct: 2641 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2700

Query: 2824 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2883
            KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK
Sbjct: 2701 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2760

Query: 2884 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2943
            LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT
Sbjct: 2761 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2820

Query: 2944 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 3003
            DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT
Sbjct: 2821 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 2880

Query: 3004 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 3063
            TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER
Sbjct: 2881 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 2940

Query: 3064 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3123
            AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL
Sbjct: 2941 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3000

Query: 3124 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3183
            LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
Sbjct: 3001 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3060

Query: 3184 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3243
            NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ
Sbjct: 3061 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3120

Query: 3244 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3303
            IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA
Sbjct: 3121 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3180

Query: 3304 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3363
            AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT
Sbjct: 3181 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3240

Query: 3364 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3423
            TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA
Sbjct: 3241 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3300

Query: 3424 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3483
            SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS
Sbjct: 3301 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3360

Query: 3484 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3543
            PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP
Sbjct: 3361 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3420

Query: 3544 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3603
            EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE
Sbjct: 3421 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3480

Query: 3604 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3663
            AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL
Sbjct: 3481 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3540

Query: 3664 NNSFPSSRGRNTPGKPMREDTM 3685
            NNSFPSSRGRNTPGKPMREDTM
Sbjct: 3541 NNSFPSSRGRNTPGKPMREDTM 3562


>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
          Length = 2341

 Score = 4598 bits (11927), Expect = 0.0
 Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)

Query: 1355 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1414
            +++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 11   YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70

Query: 1415 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
            SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 71   SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130

Query: 1475 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534
            KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 131  KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190

Query: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1594
            TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 191  TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250

Query: 1595 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1654
            TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 251  TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310

Query: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1714
            LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 311  LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370

Query: 1715 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1774
            DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 371  DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430

Query: 1775 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1834
            KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 431  KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490

Query: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894
            QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 491  QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550

Query: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1954
            DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 551  DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610

Query: 1955 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 2014
            RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 611  RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670

Query: 2015 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2074
            EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 671  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730

Query: 2075 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2134
            QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 731  QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790

Query: 2135 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2194
            NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 791  NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850

Query: 2195 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2254
            VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 851  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910

Query: 2255 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2314
            LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 911  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970

Query: 2315 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2374
            EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 971  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030

Query: 2375 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2434
            KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090

Query: 2435 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2494
            GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150

Query: 2495 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2554
            SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210

Query: 2555 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2614
            ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270

Query: 2615 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2674
            AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330

Query: 2675 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2734
            KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390

Query: 2735 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2794
            MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450

Query: 2795 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2854
            NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510

Query: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914
            LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570

Query: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974
            WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 3034
            LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690

Query: 3035 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 3094
            VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750

Query: 3095 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3154
            LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810

Query: 3155 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3214
            TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870

Query: 3215 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3274
            YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930

Query: 3275 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3334
            EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990

Query: 3335 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3394
            DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050

Query: 3395 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3454
            LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110

Query: 3455 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3514
            LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170

Query: 3515 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3574
            EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230

Query: 3575 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3634
            RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290

Query: 3635 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3685
            QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341



 Score =  209 bits (531), Expect = 5e-53
 Identities = 384/1926 (19%), Positives = 785/1926 (40%), Gaps = 263/1926 (13%)

Query: 919  KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 971
            ++V S +   +K+LQ   D     R  +  +     +Q+S     E K+ +P L     +
Sbjct: 94   QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150

Query: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
             E+++ +L     L  SL E +S +  +  T +++ +K  +E  ++       ++  + +
Sbjct: 151  QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210

Query: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
            L +++ E  Q+LE+ +   RK++  +  L +W+A  D+ L +     G    L  ++   
Sbjct: 211  LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270

Query: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
            +    +I+  +  L S+ E G+ +K     +  + +E +L  LN+ W  +  +       
Sbjct: 271  KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329

Query: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
            L    +   +  +++  + +W+ QA+   L  + E K P   Q+  + +KR K E     
Sbjct: 330  LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384

Query: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1266
             KV    +   +++A      ++ ++ ++  L   +  +  R+  GK     K LE+  +
Sbjct: 385  PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444

Query: 1267 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1323
               +LL  LE   +    L E +F     E+  G  +E+ +  D+L+  +   E    +I
Sbjct: 445  DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT-DERKREEI 503

Query: 1324 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1383
            +I  Q               L+T ++  ++L  +  RR+K LE S Q  Q   ++  L+ 
Sbjct: 504  KIKQQL--------------LQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDLL- 546

Query: 1384 ESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------HEI 1422
            + L  I+K+LA+     D+    ++ +E QK + +L +                    +I
Sbjct: 547  KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 606

Query: 1423 SLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESKMI 1477
             L +  +  + K A  R L  +QI   +++   V    M   +   P+ +   +      
Sbjct: 607  QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 666

Query: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537
            L EV+  L A +  + + E +  Q     N+  SL +    ++++       +Q      
Sbjct: 667  LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 726

Query: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597
              +L E ++ L   + ++     +R+ + ++ ++  R+   ++ +  +WL   +  L K 
Sbjct: 727  RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 786

Query: 1598 SAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLS 1654
                 +P N + ++  W  K  Q  I +++  ++++   GE +     K + +++++KL 
Sbjct: 787  Q----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 842

Query: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKKKP 1710
             LN  W  V  +  +    L E +  +  F ++++    W+ +AD +    L+  ++++ 
Sbjct: 843  SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL 902

Query: 1711 QQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI 1767
            ++K + +K L  EL     I  +++ T      + A      +  +E ++ + N ++  +
Sbjct: 903  KEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWIKV 961

Query: 1768 SHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNEGT 1823
            S  +  K G+    +K+L Q    ++K LE LE ++   +       N  +  N+ N+  
Sbjct: 962  SRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 1017

Query: 1824 VKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1883
              ++ +    +Q +  D    EEI  K Q L  +  A + +    ++K  ++S +W    
Sbjct: 1018 PFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW---- 1066

Query: 1884 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 1943
                                      + +  + +EL+ K+ +L      A GL+  GA+ 
Sbjct: 1067 --------------------------KAVNRLLQELRAKQPDL------APGLTTIGAS- 1093

Query: 1944 AVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTE 2003
               PTQ                          TV   T  V+T++  +    +PS+ + E
Sbjct: 1094 ---PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLMLE 1124

Query: 2004 I----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRI- 2052
            +          T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   ++ 
Sbjct: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184

Query: 2053 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2112
            ++I + +    +++    R  + + + ++  QW++V +  ++R+ + +            
Sbjct: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM---------- 1234

Query: 2113 IKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVR 2160
            +K   QWL    EAEQ L + +   E+W+   Y            K+L   + Q QT V 
Sbjct: 1235 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVD 1294

Query: 2161 TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDL 2220
              N    ++++  S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL
Sbjct: 1295 VANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDL 1354

Query: 2221 NEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNET 2273
             +F+ WL EA+  A++  +  ++++L E  + VK L+++    QG       +   L+E 
Sbjct: 1355 EKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN 1414

Query: 2274 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2333
               +L S   S ++   L+ +L   N +W ++ +     +  +EA      +L   L++ 
Sbjct: 1415 SQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE- 1472

Query: 2334 EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEK 2393
                  LL+WL       E+  Q    G F       AVQ KQ DV     +   L  ++
Sbjct: 1473 ------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKE 1515

Query: 2394 PATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVV 2450
            P        +    +E   + + +L QE R   P+             Q VT L+ +   
Sbjct: 1516 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAE 1565

Query: 2451 TKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--E 2504
               T   KL + S+    ++    +  +   E TD L L     +VIK     VGDL  +
Sbjct: 1566 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625

Query: 2505 DINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEV 2564
             + + + K KA   ++   +  +  +   A+ L           + T  +E +  +W  +
Sbjct: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLL 1683

Query: 2565 QEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKK 2619
            Q  +++R +QL+E  +D    S  +L    +       +  K+  +      T      K
Sbjct: 1684 QVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPK 1743

Query: 2620 ITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASW 2670
            +TE  Q   DL   + +          +   L L LL   +A D    H + +N      
Sbjct: 1744 MTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDI 1803

Query: 2671 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2730
              I   ++     LE+ H  L   PL ++  L WL     T       T + R+L    G
Sbjct: 1804 LQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTG 1858

Query: 2731 VKELMK 2736
            +  L K
Sbjct: 1859 IISLCK 1864



 Score =  181 bits (460), Expect = 9e-45
 Identities = 319/1726 (18%), Positives = 700/1726 (40%), Gaps = 236/1726 (13%)

Query: 759  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 818
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 53   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109

Query: 819  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 878
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 110  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166

Query: 879  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 936
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 167  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226

Query: 937  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 996
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 227  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284

Query: 997  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1056
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 285  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343

Query: 1057 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1114
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 344  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396

Query: 1115 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1173
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 397  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456

Query: 1174 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 457  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500

Query: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1293
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 501  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560

Query: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 561  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614

Query: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1413
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 615  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673

Query: 1414 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1440
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 674  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733

Query: 1441 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1495
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 734  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791

Query: 1496 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1555
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 792  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851

Query: 1556 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1615
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 852  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910

Query: 1616 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1665
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 911  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970

Query: 1666 RAEEWLNLLLEYQKHMETFDQNVDHITKWI---------------------------IQA 1698
              E  +  L + +K +E  ++ ++H+  W+                           +QA
Sbjct: 971  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030

Query: 1699 -----DTLLDESE---KKKP------QQKEDVLKRLKAE---LNDIRPKVDSTRDQAANL 1741
                 + +L + +   K+KP      ++ ED+    KA    L ++R K          +
Sbjct: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090

Query: 1742 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFN---SDIQKLLEPLE 1798
             A+       + +P ++    +  AIS         + +  L  FN   +++   L  L+
Sbjct: 1091 GASPTQTVTLVTQPVVT----KETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 1146

Query: 1799 AEIQ---------QGVN---LKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1846
              I+         + +N   +K++   +D+ E     ++EL+    NL+ + +++  R  
Sbjct: 1147 QVIKSQRVMVGDLEDINEMIIKQKATMQDL-EQRRPQLEELITAAQNLKNKTSNQEARTI 1205

Query: 1847 IKIKQQLLQTKHNALKDLRSQRRKKALEI---SHQWYQYKRQADDLL------------- 1890
            I  + + +Q + + +++    RR++  E+   S QW + K +A+ +L             
Sbjct: 1206 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 1265

Query: 1891 -KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA---MAVE 1946
               +D I+KK+          + K++ ++L++ +  ++     A  L  D +A     V 
Sbjct: 1266 PYTVDAIQKKIT---------ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316

Query: 1947 PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTE--- 2003
                 ++  WR I  + ++ R     + H         + +  PL++      +LTE   
Sbjct: 1317 MITENINASWRSIHKRVSE-REAALEETHR--------LLQQFPLDLEKF-LAWLTEAET 1366

Query: 2004 ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAAL 2063
              +V Q     E+LL      +K  ++L KQ + L+   ++       +D    K   +L
Sbjct: 1367 TANVLQDATRKERLLED----SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 1422

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL-TE 2122
            + +   + V LQ  L  ++F+W ++ K   + +   + S ++W+R H  ++    WL  +
Sbjct: 1423 EGSD--DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 1480

Query: 2123 AEQFLRKTQI--------PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATG-----EEI 2169
             ++  R+  I         +N  H  +K  LK  +  I      VR           E++
Sbjct: 1481 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 1540

Query: 2170 IQ--------QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLN 2221
             Q        + ++    +L+++   +N  W+++    +D +++++E    L E Q   +
Sbjct: 1541 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 1600

Query: 2222 EFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVEEL-PLRQGILKQLNETGGPVL 2278
            E  L L +A+ I     P+       L++ LE+VK L  E+ PL++ +    +       
Sbjct: 1601 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 1660

Query: 2279 VSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2324
            +   +SP     LE+     N +W  +  A+ ++  ++    +D G
Sbjct: 1661 LGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVRQLHEAHRDFG 1702



 Score =  130 bits (326), Expect = 3e-29
 Identities = 219/1087 (20%), Positives = 429/1087 (39%), Gaps = 107/1087 (9%)

Query: 344  YQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLG 403
            Y T +  V   LL  E  L A    + D E +  Q  + +     L    GR+  I    
Sbjct: 656  YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS-- 713

Query: 404  SKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELN 461
             K       +  E  ++QE ++ L+ +WE +     ++Q    R +   +  +  +K  N
Sbjct: 714  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 773

Query: 462  DWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS 521
             WLT+ E+  RK +     P+  +  +     K LQ+ + Q Q  V +L      + + S
Sbjct: 774  QWLTEAEQFLRKTQI----PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 829

Query: 522  GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD---ILLKWQRLTEEQCLFSAWLSEK 578
                 + L+E+L  L  RW  +C+   DR   L++   IL ++QR   E   F  WL E+
Sbjct: 830  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE---FVLWL-EE 885

Query: 579  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 638
             D +  I     K+Q            LK  LE+ K  + +L  L+Q +L  L       
Sbjct: 886  ADNIASIPLEPGKEQQ-----------LKEKLEQVKLLVEEL-PLRQGILKQLNETGGPV 933

Query: 639  KTEAWLDNFARCWDNLVQKLEKSTAQ---ISQAVTTTQPSLTQTTVMETVTTVTTREQIL 695
               A +    +  D L  KL+++  Q   +S+A+   Q  + +  + +            
Sbjct: 934  LVSAPISPEEQ--DKLENKLKQTNLQWIKVSRALPEKQGEI-EAQIKD------------ 978

Query: 696  VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 755
            +   +++L     Q    +   S IR +L++     +         +Q  E A+  K+ +
Sbjct: 979  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI----YNQPNQEGPFDVQETEIAVQAKQPD 1034

Query: 756  FSDLKEKVNAIEREKAEK---FRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 812
              ++  K   + +EK       RKL+D S   +A+   +         +      + +  
Sbjct: 1035 VEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094

Query: 813  IEFCQLLSE-------RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-------KIQPT 858
             +   L+++        ++ LE  ++++     L    +  T   +WL       K Q  
Sbjct: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154

Query: 859  TPSEPTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFV-AFT 915
               +   I   +   K  +  L   +PQ+E L    Q++  K   Q    +  D +    
Sbjct: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            N + +V   +Q R ++L  +       ++ E        + Q+  KL   +      + +
Sbjct: 1215 NQWDEVQEHLQNRRQQLNEMLK--DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1272

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1035
            ++++ E + L   L++ Q+ +   +    ++ +   ++ +RK     E I   W+ +  +
Sbjct: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332

Query: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV--------DVFLKEEWPALGDSEILKKQ 1087
            + E    LEE    L++    ++    W+ E         D   KE    L DS+ +K+ 
Sbjct: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER--LLEDSKGVKEL 1390

Query: 1088 LKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE-PEFASRLETELKELNTQWDHMCQQVY 1146
            +KQ + L  +I+      ++++E  QKI    E  + A  L+  L  +N +W  + ++  
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450

Query: 1147 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEE 1206
              +  L+   ++   L   L E+  W+   ++E   +         +QK  +  +  K E
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510

Query: 1207 AQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE---------LETLTTNYQWLCTRLNGK 1257
             + KE  +    E+V   + + P    E L +E          + +T   +     +N +
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570

Query: 1258 CKTLEEVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL-DSLENL 1312
             + L    A W     E L  L++  +  +E++ KL+  E I G  + + ++L DSL++ 
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630

Query: 1313 MRH----------SEDNPNQIRILAQTLTDGGVMDELIN-EELETFNSRWRELHEEAVRR 1361
            +             ++N + +  LA+ LT  G+     N   LE  N+RW+ L      R
Sbjct: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690

Query: 1362 QKLLEQS 1368
             + L ++
Sbjct: 1691 VRQLHEA 1697



 Score =  110 bits (276), Expect = 2e-23
 Identities = 200/1036 (19%), Positives = 413/1036 (39%), Gaps = 155/1036 (14%)

Query: 653  NLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKR 712
            N+   L++S+ +I    +    +L   T +E V       Q+  +  +         K R
Sbjct: 696  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN----KMYKDR 751

Query: 713  QITVDSEIRK--RLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREK 770
            Q   D  + K  R   DI   + W+T +E  L+  +        N+   K K     +E 
Sbjct: 752  QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-----ENWEHAKYKWYL--KEL 804

Query: 771  AEKFRKLQDASRSAQALVEQMVNEGVNADS--IKQASEQLNSRWIEFCQLLSERLNWLEY 828
             +   + Q   R+  A  E+++ +    D+  +++    LN RW E C+ LS+R   LE 
Sbjct: 805  QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 864

Query: 829  QNNIIA-FYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIK---SQLKICKDEVNRLSGLQ 884
            Q NI++ F   L +       A+N   I P  P +   +K    Q+K+  +E+    G+ 
Sbjct: 865  QKNILSEFQRDLNEFVLWLEEADNIASI-PLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 923

Query: 885  PQIER-----LKIQSIALKEKGQGPMFL---DADFVAFTNHFKQVFSDVQAREKELQTIF 936
             Q+       L    I+ +E+ +    L   +  ++  +    +   +++A+ K+L  + 
Sbjct: 924  KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 983

Query: 937  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 996
              L  +  +E ++ +  W+     +L I        +  ++   ++Q  + ++Q +Q  +
Sbjct: 984  KKLEDL--EEQLNHLLLWLSPIRNQLEIYN------QPNQEGPFDVQETEIAVQAKQPDV 1035

Query: 997  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVE------------------ 1038
              + +  + + K+ P+  ++  + + E++   WK ++  L E                  
Sbjct: 1036 EEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1093

Query: 1039 -----------------HCQKLEEQMNKLRKIQ-----NHIQT-LKKWMAEVDVFLKEEW 1075
                                KLE   + + ++      N   T L  W++ +D  +K + 
Sbjct: 1094 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1153

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE-LKEL 1134
              +GD E + + + + +  + D++  +P L  +    Q +KN+   + A  + T+ ++ +
Sbjct: 1154 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1213

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              QWD + + +  R++ L   L+ +    +   E  + + QA  +         T D +Q
Sbjct: 1214 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1273

Query: 1195 KAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW--LCT 1252
            K + E K+  ++ +Q +  V +  +    ++      A +  K  + T   N  W  +  
Sbjct: 1274 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKVHMITENINASWRSIHK 1331

Query: 1253 RLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGA---EEISEVLDSL 1309
            R++ +   LEE      +    LEK   WL E E    TT N+   A   E + E    +
Sbjct: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 1387

Query: 1310 ENLMRHSED---------------NPNQIRILAQTLTDGGVMDELINEELETFNSRWREL 1354
            + LM+  +D               + N  +IL     +G     L+   L+  N +W EL
Sbjct: 1388 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAVLLQRRLDNMNFKWSEL 1445

Query: 1355 HEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA--AYIADKVDAAQMPQ 1408
             ++++     +   ++++ +  K LHL +QE L ++   D +L+  A I     A Q   
Sbjct: 1446 RKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1501

Query: 1409 EAQK------------IQSDLTSHEISLEEM------KKHNQGKE--AAQRVLSQIDVAQ 1448
            +  +            I S L +  I L E       K + + +E    +R  +   + +
Sbjct: 1502 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1561

Query: 1449 KKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVV--------- 1498
            K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K  + EV+         
Sbjct: 1562 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD 1621

Query: 1499 ------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY 1552
                  Q  L     L   ++ +K  V  V    RQ+       +P  L   +  L   +
Sbjct: 1622 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRW 1680

Query: 1553 NELGAKVTERKQQLEK 1568
              L   V +R +QL +
Sbjct: 1681 KLLQVAVEDRVRQLHE 1696



 Score =  107 bits (266), Expect = 3e-22
 Identities = 243/1327 (18%), Positives = 525/1327 (39%), Gaps = 212/1327 (15%)

Query: 416  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 472
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 301  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359

Query: 473  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 532
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 360  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412

Query: 533  LKVLGDRWANICR--WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 590
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 413  ISELNHRFAAISHRIKTGKASIPLKEL---EQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469

Query: 591  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 633
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 470  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525

Query: 634  KSVTQKTEAW------LDNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 679
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 526  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585

Query: 680  --------------TVMETVTTVTTR-EQILVKHAQ------EELPPPPPQKKRQITVD- 717
                           V  T   ++ R  +I  K AQ       ++     +    +T D 
Sbjct: 586  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645

Query: 718  ----SEIRKRLDVDITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKV---- 763
                S +      +IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 646  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705

Query: 764  NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 823
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 706  GRIDIIHSKKTAALQSAT-------------PVERVKLQEALSQLDFQWEKVNKMYKDRQ 752

Query: 824  --------NWLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 872
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 753  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803

Query: 873  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 932
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 804  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862

Query: 933  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 992
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 863  EEQKNIL--SEFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919

Query: 993  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1050
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 920  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979

Query: 1051 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1106
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 980  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036

Query: 1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGL------- 1156
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094

Query: 1157 EKTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1185
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154

Query: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKV-KLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                 +++ + + + K   ++ +Q+  ++ +L+T + N     +   A+  +   +E + 
Sbjct: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274

Query: 1305 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1359
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334

Query: 1360 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1410
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394

Query: 1411 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1469
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454

Query: 1470 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1519
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514

Query: 1520 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1579
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566

Query: 1580 MNVLTEW 1586
            +N  TEW
Sbjct: 1567 VN--TEW 1571



 Score = 65.9 bits (159), Expect = 7e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 302  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 361
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148

Query: 362  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 421
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200

Query: 422  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 474
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259

Query: 475  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 533
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319

Query: 534  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 591
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379

Query: 592  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 648
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439

Query: 649  RCWDNLVQK 657
              W  L +K
Sbjct: 1440 FKWSELRKK 1448



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456

Query: 323  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504

Query: 383  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564

Query: 425  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619

Query: 480  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675

Query: 536  LGDRWANICRWTEDR 550
            L  RW  +    EDR
Sbjct: 1676 LNTRWKLLQVAVEDR 1690


>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
          Length = 2344

 Score = 4597 bits (11923), Expect = 0.0
 Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)

Query: 1358 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1417
            AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76

Query: 1418 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477
            TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 77   TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136

Query: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537
            LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 137  LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196

Query: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597
            PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 197  PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256

Query: 1598 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1657
            SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 257  SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316

Query: 1658 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1717
            SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 317  SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376

Query: 1718 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1777
            KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 377  KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436

Query: 1778 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
            IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 437  IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496

Query: 1838 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1897
            ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 497  ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556

Query: 1898 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1957
            KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 557  KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616

Query: 1958 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 2017
            EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676

Query: 2018 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 2077
            LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736

Query: 2078 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2137
            LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796

Query: 2138 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2197
            HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 797  HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856

Query: 2198 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2257
            QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 857  QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916

Query: 2258 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2317
            EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 917  EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976

Query: 2318 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2377
            AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036

Query: 2378 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2437
            DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096

Query: 2438 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2497
            PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156

Query: 2498 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2557
            VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216

Query: 2558 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2617
            QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276

Query: 2618 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2677
            KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336

Query: 2678 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2737
            SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396

Query: 2738 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2797
            WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456

Query: 2798 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2857
            SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516

Query: 2858 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2917
            KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576

Query: 2918 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2977
            LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636

Query: 2978 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3037
            VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696

Query: 3038 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 3097
            LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756

Query: 3098 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3157
            LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816

Query: 3158 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3217
            YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876

Query: 3218 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3277
            LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936

Query: 3278 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3337
            AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996

Query: 3338 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3397
            QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056

Query: 3398 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3457
            QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116

Query: 3458 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3517
            SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176

Query: 3518 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3577
            RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236

Query: 3578 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3637
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296

Query: 3638 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3685
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344



 Score =  181 bits (460), Expect = 9e-45
 Identities = 319/1726 (18%), Positives = 700/1726 (40%), Gaps = 236/1726 (13%)

Query: 759  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 818
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 56   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112

Query: 819  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 878
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 113  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169

Query: 879  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 936
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 170  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229

Query: 937  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 996
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 230  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287

Query: 997  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1056
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 288  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346

Query: 1057 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1114
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 347  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399

Query: 1115 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1173
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 400  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459

Query: 1174 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503

Query: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1293
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 504  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563

Query: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 564  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617

Query: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1413
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 618  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676

Query: 1414 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1440
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736

Query: 1441 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1495
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794

Query: 1496 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1555
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 795  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854

Query: 1556 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1615
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 855  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913

Query: 1616 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1665
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973

Query: 1666 RAEEWLNLLLEYQKHMETFDQNVDHITKWI---------------------------IQA 1698
              E  +  L + +K +E  ++ ++H+  W+                           +QA
Sbjct: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1033

Query: 1699 -----DTLLDESE---KKKP------QQKEDVLKRLKAE---LNDIRPKVDSTRDQAANL 1741
                 + +L + +   K+KP      ++ ED+    KA    L ++R K          +
Sbjct: 1034 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093

Query: 1742 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFN---SDIQKLLEPLE 1798
             A+       + +P ++    +  AIS         + +  L  FN   +++   L  L+
Sbjct: 1094 GASPTQTVTLVTQPVVT----KETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 1149

Query: 1799 AEIQ---------QGVN---LKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1846
              I+         + +N   +K++   +D+ E     ++EL+    NL+ + +++  R  
Sbjct: 1150 QVIKSQRVMVGDLEDINEMIIKQKATMQDL-EQRRPQLEELITAAQNLKNKTSNQEARTI 1208

Query: 1847 IKIKQQLLQTKHNALKDLRSQRRKKALEI---SHQWYQYKRQADDLL------------- 1890
            I  + + +Q + + +++    RR++  E+   S QW + K +A+ +L             
Sbjct: 1209 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 1268

Query: 1891 -KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA---MAVE 1946
               +D I+KK+          + K++ ++L++ +  ++     A  L  D +A     V 
Sbjct: 1269 PYTVDAIQKKIT---------ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1319

Query: 1947 PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTE--- 2003
                 ++  WR I  + ++ R     + H         + +  PL++      +LTE   
Sbjct: 1320 MITENINASWRSIHKRVSE-REAALEETHR--------LLQQFPLDLEKF-LAWLTEAET 1369

Query: 2004 ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAAL 2063
              +V Q     E+LL      +K  ++L KQ + L+   ++       +D    K   +L
Sbjct: 1370 TANVLQDATRKERLLED----SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 1425

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL-TE 2122
            + +   + V LQ  L  ++F+W ++ K   + +   + S ++W+R H  ++    WL  +
Sbjct: 1426 EGSD--DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 1483

Query: 2123 AEQFLRKTQI--------PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATG-----EEI 2169
             ++  R+  I         +N  H  +K  LK  +  I      VR           E++
Sbjct: 1484 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 1543

Query: 2170 IQ--------QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLN 2221
             Q        + ++    +L+++   +N  W+++    +D +++++E    L E Q   +
Sbjct: 1544 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 1603

Query: 2222 EFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVEEL-PLRQGILKQLNETGGPVL 2278
            E  L L +A+ I     P+       L++ LE+VK L  E+ PL++ +    +       
Sbjct: 1604 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 1663

Query: 2279 VSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2324
            +   +SP     LE+     N +W  +  A+ ++  ++    +D G
Sbjct: 1664 LGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVRQLHEAHRDFG 1705



 Score =  178 bits (452), Expect = 8e-44
 Identities = 385/1950 (19%), Positives = 769/1950 (39%), Gaps = 249/1950 (12%)

Query: 939  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 994
            L  +R Q+ +       Q++E  L + Q S+T  D ++      ++ A Q   + Q  QS
Sbjct: 15   LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74

Query: 995  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1054
             L     +++EM K   ++     Q    +I+   KKL    ++          K    +
Sbjct: 75   DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127

Query: 1055 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 1114
              +Q  K  + EV + L        + E+++ QL  C  L   +  ++  +  V + G++
Sbjct: 128  QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187

Query: 1115 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1174
            I  + + E    L+  +  L   ++ +  +V  RK+ L+  L+ +  ++K+++ + EW+ 
Sbjct: 188  IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247

Query: 1175 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1234
              + E  +R      P  L   V   K  ++E ++++  +K +TE              E
Sbjct: 248  ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295

Query: 1235 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1294
            ALK  L           T +  K   L   W      ++   +A +WLN +    K  E 
Sbjct: 296  ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342

Query: 1295 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
                 + I++ +   + L+  SE   P Q   + + L     ++++  +   T +     
Sbjct: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400

Query: 1354 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1411
            +       +KL+E  I        ++ H I+     I  K+L  + +D +     P EA+
Sbjct: 401  MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459

Query: 1412 KIQSDLTSHEISLEEMKKHNQG--KEAAQR--VLSQIDVAQKKLQDVSMKFRLFQKPANF 1467
              Q      E   ++M + N+G  KE  QR   L Q    ++K +++ +K +L Q   N 
Sbjct: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNA 519

Query: 1468 --EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKT 1525
              + R Q  K  L+   +     + K    ++++  L+       SL E + E   + + 
Sbjct: 520  LKDLRSQRRKKALE---ISHQWYQYKRQADDLLKC-LDDIEKKLASLPEPRDE-RKIKEI 574

Query: 1526 GRQIVQKKQTEN-----PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM---- 1576
             R++ +KK+  N      + L E   A+ +   ++  ++++R +++E      R++    
Sbjct: 575  DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI--QLSKRWREIESKFAQFRRLNFAQ 632

Query: 1577 -----RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIE--------- 1622
                  + M V+TE     DM L     +  +PS   +E+        E+E         
Sbjct: 633  IHTVREETMMVMTE-----DMPL----EISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 683

Query: 1623 --------KQKVHLKSI---------------TEVGEALKTVLGKKETLVEDKLSLLNSN 1659
                    KQ+  LK+I               ++   AL++    +   +++ LS L+  
Sbjct: 684  AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 743

Query: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDV 1716
            W  V    ++         +    F  ++    +W+ +A+  L ++   E  +  + +  
Sbjct: 744  WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803

Query: 1717 LKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKA 1776
            LK L+  +   +  V +       ++         +++ ++  LN R+  +  ++   K 
Sbjct: 804  LKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863

Query: 1777 SIPLKE--LEQFNSDIQKLL-----------EPLEAEIQQGVNLKEEDFNKDMNE--DNE 1821
             +  ++  L +F  D+ + +            PLE   +Q +  K E     + E    +
Sbjct: 864  RLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQ 923

Query: 1822 GTVKELLQRGDNLQQRI---TDERKREEIKIKQQLLQ--TKHNALKDLRSQ---RRKKAL 1873
            G +K+L + G  +        +E+ + E K+KQ  LQ      AL + + +   + K   
Sbjct: 924  GILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 983

Query: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER--KIKEIDRELQKKKEELNAVRR 1931
            ++  +    + Q + LL  L  I  +L    +P  E    ++E +  +Q K+ ++  +  
Sbjct: 984  QLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1043

Query: 1932 QAEGL-SEDGAAMAVEPTQIQLSKRWREIESKFAQFR-----------RLNFAQIHTVRE 1979
            + + L  E  A   V+     LS  W+ +     + R            +  +   TV  
Sbjct: 1044 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103

Query: 1980 ETMMVMTEDMPLEISYVPSTYLTEI----------THVSQALLEVEQLLNAPDLCAKDFE 2029
             T  V+T++  +    +PS+ + E+          T ++  L  ++Q++ +  +   D E
Sbjct: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1163

Query: 2030 DLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 2088
            D+ +     K     L+Q   ++ ++I + +    +++    R  + + + ++  QW++V
Sbjct: 1164 DINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEV 1223

Query: 2089 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK-- 2142
             +  ++R+ + +            +K   QWL    EAEQ L + +   E+W+   Y   
Sbjct: 1224 QEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1273

Query: 2143 ------WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2196
                     K+L   + Q QT V   N    ++++  S  D   +     ++N  W+ + 
Sbjct: 1274 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLL 2256
            K++S+R+  LEE   +L +F  DL +F+ WL EA+  A++  +  ++++L E  + VK L
Sbjct: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393

Query: 2257 VEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL 2309
            +++    QG       +   L+E    +L S   S ++   L+ +L   N +W ++ +  
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKS 1452

Query: 2310 PEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETE 2369
               +  +EA      +L   L++       LL+WL       E+  Q    G F      
Sbjct: 1453 LNIRSHLEASSDQWKRLHLSLQE-------LLVWLQ--LKDDELSRQAPIGGDFP----- 1498

Query: 2370 IAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDL 2427
             AVQ KQ DV     +   L  ++P        +    +E   + + +L QE R   P+ 
Sbjct: 1499 -AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE- 1553

Query: 2428 APGLTTIGASPTQTVT-LVTQPVVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDW 2485
                        Q VT L+ +      T   KL + S+    ++    +  +   E TD 
Sbjct: 1554 ---------ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDE 1604

Query: 2486 LSL---LDQVIKSQRVMVGDL--EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 2540
            L L     +VIK     VGDL  + + + + K KA   ++   +  +  +   A+ L   
Sbjct: 1605 LDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTL 1664

Query: 2541 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVL 2596
                    + T  +E +  +W  +Q  +++R +QL+E  +D    S  +L    +     
Sbjct: 1665 GIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 1722

Query: 2597 GQARAKLESW-KEGPYTVDAIQKKITETKQLAKDLRQWQTNV--------DVANDLALKL 2647
              +  K+  +      T      K+TE  Q   DL   + +          +   L L L
Sbjct: 1723 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 1782

Query: 2648 LRDYSADDTRKVHMITENIN-ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT 2706
            L   +A D    H + +N        I   ++     LE+ H  L   PL ++  L WL 
Sbjct: 1783 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 1842

Query: 2707 EAETTANVLQDATRKERLLEDSKGVKELMK 2736
                T       T + R+L    G+  L K
Sbjct: 1843 NVYDTGR-----TGRIRVLSFKTGIISLCK 1867



 Score =  130 bits (326), Expect = 3e-29
 Identities = 219/1087 (20%), Positives = 429/1087 (39%), Gaps = 107/1087 (9%)

Query: 344  YQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLG 403
            Y T +  V   LL  E  L A    + D E +  Q  + +     L    GR+  I    
Sbjct: 659  YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS-- 716

Query: 404  SKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELN 461
             K       +  E  ++QE ++ L+ +WE +     ++Q    R +   +  +  +K  N
Sbjct: 717  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776

Query: 462  DWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS 521
             WLT+ E+  RK +     P+  +  +     K LQ+ + Q Q  V +L      + + S
Sbjct: 777  QWLTEAEQFLRKTQI----PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 832

Query: 522  GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD---ILLKWQRLTEEQCLFSAWLSEK 578
                 + L+E+L  L  RW  +C+   DR   L++   IL ++QR   E   F  WL E+
Sbjct: 833  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE---FVLWL-EE 888

Query: 579  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 638
             D +  I     K+Q            LK  LE+ K  + +L  L+Q +L  L       
Sbjct: 889  ADNIASIPLEPGKEQQ-----------LKEKLEQVKLLVEEL-PLRQGILKQLNETGGPV 936

Query: 639  KTEAWLDNFARCWDNLVQKLEKSTAQ---ISQAVTTTQPSLTQTTVMETVTTVTTREQIL 695
               A +    +  D L  KL+++  Q   +S+A+   Q  + +  + +            
Sbjct: 937  LVSAPISPEEQ--DKLENKLKQTNLQWIKVSRALPEKQGEI-EAQIKD------------ 981

Query: 696  VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 755
            +   +++L     Q    +   S IR +L++     +         +Q  E A+  K+ +
Sbjct: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI----YNQPNQEGPFDVQETEIAVQAKQPD 1037

Query: 756  FSDLKEKVNAIEREKAEK---FRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 812
              ++  K   + +EK       RKL+D S   +A+   +         +      + +  
Sbjct: 1038 VEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097

Query: 813  IEFCQLLSE-------RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-------KIQPT 858
             +   L+++        ++ LE  ++++     L    +  T   +WL       K Q  
Sbjct: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157

Query: 859  TPSEPTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFV-AFT 915
               +   I   +   K  +  L   +PQ+E L    Q++  K   Q    +  D +    
Sbjct: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            N + +V   +Q R ++L  +       ++ E        + Q+  KL   +      + +
Sbjct: 1218 NQWDEVQEHLQNRRQQLNEMLK--DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1035
            ++++ E + L   L++ Q+ +   +    ++ +   ++ +RK     E I   W+ +  +
Sbjct: 1276 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1335

Query: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV--------DVFLKEEWPALGDSEILKKQ 1087
            + E    LEE    L++    ++    W+ E         D   KE    L DS+ +K+ 
Sbjct: 1336 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER--LLEDSKGVKEL 1393

Query: 1088 LKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE-PEFASRLETELKELNTQWDHMCQQVY 1146
            +KQ + L  +I+      ++++E  QKI    E  + A  L+  L  +N +W  + ++  
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453

Query: 1147 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEE 1206
              +  L+   ++   L   L E+  W+   ++E   +         +QK  +  +  K E
Sbjct: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513

Query: 1207 AQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE---------LETLTTNYQWLCTRLNGK 1257
             + KE  +    E+V   + + P    E L +E          + +T   +     +N +
Sbjct: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573

Query: 1258 CKTLEEVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL-DSLENL 1312
             + L    A W     E L  L++  +  +E++ KL+  E I G  + + ++L DSL++ 
Sbjct: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1633

Query: 1313 MRH----------SEDNPNQIRILAQTLTDGGVMDELIN-EELETFNSRWRELHEEAVRR 1361
            +             ++N + +  LA+ LT  G+     N   LE  N+RW+ L      R
Sbjct: 1634 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1693

Query: 1362 QKLLEQS 1368
             + L ++
Sbjct: 1694 VRQLHEA 1700



 Score =  110 bits (276), Expect = 2e-23
 Identities = 200/1036 (19%), Positives = 413/1036 (39%), Gaps = 155/1036 (14%)

Query: 653  NLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKR 712
            N+   L++S+ +I    +    +L   T +E V       Q+  +  +         K R
Sbjct: 699  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN----KMYKDR 754

Query: 713  QITVDSEIRK--RLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREK 770
            Q   D  + K  R   DI   + W+T +E  L+  +        N+   K K     +E 
Sbjct: 755  QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-----ENWEHAKYKWYL--KEL 807

Query: 771  AEKFRKLQDASRSAQALVEQMVNEGVNADS--IKQASEQLNSRWIEFCQLLSERLNWLEY 828
             +   + Q   R+  A  E+++ +    D+  +++    LN RW E C+ LS+R   LE 
Sbjct: 808  QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 867

Query: 829  QNNIIA-FYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIK---SQLKICKDEVNRLSGLQ 884
            Q NI++ F   L +       A+N   I P  P +   +K    Q+K+  +E+    G+ 
Sbjct: 868  QKNILSEFQRDLNEFVLWLEEADNIASI-PLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 926

Query: 885  PQIER-----LKIQSIALKEKGQGPMFL---DADFVAFTNHFKQVFSDVQAREKELQTIF 936
             Q+       L    I+ +E+ +    L   +  ++  +    +   +++A+ K+L  + 
Sbjct: 927  KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 986

Query: 937  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 996
              L  +  +E ++ +  W+     +L I        +  ++   ++Q  + ++Q +Q  +
Sbjct: 987  KKLEDL--EEQLNHLLLWLSPIRNQLEIYN------QPNQEGPFDVQETEIAVQAKQPDV 1038

Query: 997  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVE------------------ 1038
              + +  + + K+ P+  ++  + + E++   WK ++  L E                  
Sbjct: 1039 EEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096

Query: 1039 -----------------HCQKLEEQMNKLRKIQ-----NHIQT-LKKWMAEVDVFLKEEW 1075
                                KLE   + + ++      N   T L  W++ +D  +K + 
Sbjct: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE-LKEL 1134
              +GD E + + + + +  + D++  +P L  +    Q +KN+   + A  + T+ ++ +
Sbjct: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              QWD + + +  R++ L   L+ +    +   E  + + QA  +         T D +Q
Sbjct: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276

Query: 1195 KAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW--LCT 1252
            K + E K+  ++ +Q +  V +  +    ++      A +  K  + T   N  W  +  
Sbjct: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKVHMITENINASWRSIHK 1334

Query: 1253 RLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGA---EEISEVLDSL 1309
            R++ +   LEE      +    LEK   WL E E    TT N+   A   E + E    +
Sbjct: 1335 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 1390

Query: 1310 ENLMRHSED---------------NPNQIRILAQTLTDGGVMDELINEELETFNSRWREL 1354
            + LM+  +D               + N  +IL     +G     L+   L+  N +W EL
Sbjct: 1391 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAVLLQRRLDNMNFKWSEL 1448

Query: 1355 HEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA--AYIADKVDAAQMPQ 1408
             ++++     +   ++++ +  K LHL +QE L ++   D +L+  A I     A Q   
Sbjct: 1449 RKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1504

Query: 1409 EAQK------------IQSDLTSHEISLEEM------KKHNQGKE--AAQRVLSQIDVAQ 1448
            +  +            I S L +  I L E       K + + +E    +R  +   + +
Sbjct: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1564

Query: 1449 KKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVV--------- 1498
            K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K  + EV+         
Sbjct: 1565 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD 1624

Query: 1499 ------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY 1552
                  Q  L     L   ++ +K  V  V    RQ+       +P  L   +  L   +
Sbjct: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRW 1683

Query: 1553 NELGAKVTERKQQLEK 1568
              L   V +R +QL +
Sbjct: 1684 KLLQVAVEDRVRQLHE 1699



 Score =  107 bits (266), Expect = 3e-22
 Identities = 243/1327 (18%), Positives = 525/1327 (39%), Gaps = 212/1327 (15%)

Query: 416  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 472
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 304  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362

Query: 473  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 532
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 363  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415

Query: 533  LKVLGDRWANICR--WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 590
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 416  ISELNHRFAAISHRIKTGKASIPLKEL---EQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472

Query: 591  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 633
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 473  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528

Query: 634  KSVTQKTEAW------LDNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 679
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 529  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588

Query: 680  --------------TVMETVTTVTTR-EQILVKHAQ------EELPPPPPQKKRQITVD- 717
                           V  T   ++ R  +I  K AQ       ++     +    +T D 
Sbjct: 589  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648

Query: 718  ----SEIRKRLDVDITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKV---- 763
                S +      +IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 649  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708

Query: 764  NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 823
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 709  GRIDIIHSKKTAALQSAT-------------PVERVKLQEALSQLDFQWEKVNKMYKDRQ 755

Query: 824  --------NWLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 872
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 756  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806

Query: 873  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 932
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865

Query: 933  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 992
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 866  EEQKNIL--SEFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922

Query: 993  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1050
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982

Query: 1051 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1106
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 983  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039

Query: 1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGL------- 1156
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097

Query: 1157 EKTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1185
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157

Query: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKV-KLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                 +++ + + + K   ++ +Q+  ++ +L+T + N     +   A+  +   +E + 
Sbjct: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277

Query: 1305 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1359
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337

Query: 1360 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1410
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397

Query: 1411 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1469
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457

Query: 1470 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1519
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517

Query: 1520 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1579
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569

Query: 1580 MNVLTEW 1586
            +N  TEW
Sbjct: 1570 VN--TEW 1574



 Score = 65.9 bits (159), Expect = 7e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 302  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 361
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151

Query: 362  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 421
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203

Query: 422  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 474
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262

Query: 475  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 533
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322

Query: 534  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 591
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382

Query: 592  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 648
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442

Query: 649  RCWDNLVQK 657
              W  L +K
Sbjct: 1443 FKWSELRKK 1451



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459

Query: 323  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507

Query: 383  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567

Query: 425  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622

Query: 480  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678

Query: 536  LGDRWANICRWTEDR 550
            L  RW  +    EDR
Sbjct: 1679 LNTRWKLLQVAVEDR 1693


>gi|5032293 dystrophin Dp140 isoform [Homo sapiens]
          Length = 1225

 Score = 2452 bits (6355), Expect = 0.0
 Identities = 1225/1225 (100%), Positives = 1225/1225 (100%)

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3420
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960

Query: 3421 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3480
            APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961  APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020

Query: 3481 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3540
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080

Query: 3541 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3600
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140

Query: 3601 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3660
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200

Query: 3661 EQLNNSFPSSRGRNTPGKPMREDTM 3685
            EQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1201 EQLNNSFPSSRGRNTPGKPMREDTM 1225



 Score =  100 bits (249), Expect = 3e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 2005 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2063
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2121
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 2122 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2284
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 2285 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2344
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 2345 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2404
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 2405 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2461
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 2462 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2515
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 2516 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2575
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 2576 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2630
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 2631 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2681
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)

Query: 1060 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1119
            L  W++ +D  +K +   +GD E + + + + +  + D++  +P L  +    Q +KN+ 
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1120 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1178
              + A  + T+ ++ +  QWD + + +  R++ L   L+ +    +   E  + + QA  
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1179 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1238
            +         T D +QK + E K+  ++ +Q +  V +  +    ++      A +  K 
Sbjct: 142  KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199

Query: 1239 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1296
             + T   N  W  +  R++ +   LEE      +    LEK   WL E E    TT N+ 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255

Query: 1297 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1338
              A   E + E    ++ LM+  +D               + N  +IL     +G     
Sbjct: 256  QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313

Query: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1394
            L+   L+  N +W EL ++++     +   ++++ +  K LHL +QE L ++   D +L+
Sbjct: 314  LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1395 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1434
              A I     A Q   +  +            I S L +  I L E       K + + +
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429

Query: 1435 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            E    +R  +   + +K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K
Sbjct: 430  ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489

Query: 1492 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1536
              + EV+               Q  L     L   ++ +K  V  V    RQ+       
Sbjct: 490  LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549

Query: 1537 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1568
            +P  L   +  L   +  L   V +R +QL +
Sbjct: 550  SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)

Query: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
           SSLM     L  +  A  E+  WL   +  +++Q  +  D+E + +     +  M DL  
Sbjct: 3   SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62

Query: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
            + ++  ++     L          +T  QE   ++  R E ++    E Q +L      
Sbjct: 63  RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114

Query: 452 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 503
           L N+ LK+   WL   EE  +       K+E    GP  ++ +++++ + K L +DL Q 
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 504 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 563
           Q  V+    + + +        T  +    + +   W +I +   +R   L++     Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 564 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 618
              +   F AWL+E E   N +     K     D   +   +++   L+ ++E       
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293

Query: 619 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 657
            L    Q +L +L+        +  LDN    W  L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)

Query: 944  YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 1003
            +    + +  W+   +  +   ++ V D E + + + + +A    L++++  L  L T  
Sbjct: 15   FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74

Query: 1004 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1058
            + +  K  ++ +R   ++  E I+ +W ++   L    Q+L E +      L   +   Q
Sbjct: 75   QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 1059 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1118
             L +  A+++ +  +E P   D+  ++K++ + + L  D++  Q +++  N+   K+  +
Sbjct: 135  VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190

Query: 1119 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1177
               +   ++    + +N  W  + ++V  R+ AL+           DL +   W+T+AE 
Sbjct: 191  YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250

Query: 1178 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1233
                L+     +   E  K V+E+ +  ++ Q   +    V    +  +  I ++   + 
Sbjct: 251  TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310

Query: 1234 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1275
            +A+  +      N++W   R     +    +   + W   H    ELL +L         
Sbjct: 311  DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370

Query: 1276 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1318
                       +K N      + +LKT E +     E   +      L+ LE L +   +
Sbjct: 371  QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430

Query: 1319 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
             P + R  AQ +T       L+ ++ E  N+ W +L+  +   Q+ ++++++  QE +++
Sbjct: 431  LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)

Query: 729  TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 785
            TEL  W++  + V++S    +    G+  D+ E   K  A  ++  ++  +L++   +AQ
Sbjct: 20   TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75

Query: 786  ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 844
             L  +  N+      I    E++ ++W E  + L  R   L E   +   +    ++ EQ
Sbjct: 76   NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 845  MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 904
            +   A   L+     P    AI+ ++   K     L   Q  ++     ++ L       
Sbjct: 135  VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194

Query: 905  MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
                   +       ++ +   V  RE  L+     L   ++   +     W+ ++ET  
Sbjct: 195  DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252

Query: 963  SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
            ++ Q +     ++E   G      + Q LQ  ++      + L    +++ +    S+ +
Sbjct: 253  NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
               Q   + +  +W +L  + +     LE   ++ +++   +Q L  W+   D  L  + 
Sbjct: 313  VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1120
            P  GD   ++KQ    R    +++T +P + S              EG +K+     E  
Sbjct: 373  PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432

Query: 1121 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
            PE  ++     L  + +E+NT+W+ +       +  +   LE+   LQ+   E+   + Q
Sbjct: 433  PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492

Query: 1176 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1232
            A  E ++  ++       D LQ  +E++K  + E    +  V  + +    +      ++
Sbjct: 493  A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550

Query: 1233 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
               L   LE L T ++ L   +  + + L E
Sbjct: 551  PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)

Query: 1510 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1568
            + L + + ++E +I   + +  K   +  + +  +R+  ++  ++E+   +  R+QQL +
Sbjct: 58   QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117

Query: 1569 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1628
             LK S +  +      + L     +L            +  ++   K   K++ + + ++
Sbjct: 118  MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177

Query: 1629 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1687
                ++   L       +T     ++  +N++W ++  R  E    L E  + ++ F  +
Sbjct: 178  DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237

Query: 1688 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            ++    W+ +A+T    L D + K++  +    +K L  +  D++ ++++  D   NL  
Sbjct: 238  LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297

Query: 1744 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
            N         G     L++ ++  +N +++ +       K S+ ++   + +SD  K L 
Sbjct: 298  NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351

Query: 1796 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1842
                E+   + LK+++ ++              N+ +    +EL  +   +   +   R 
Sbjct: 352  LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411

Query: 1843 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1895
                + ++  ++L Q       + R+Q      RK+A E++ +W +    + D  + +D+
Sbjct: 412  FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471

Query: 1896 IEKKLASLPEPRDERKIKEIDRELQK 1921
              ++L  L E  DE  +K    E+ K
Sbjct: 472  TLERLQELQEATDELDLKLRQAEVIK 497



 Score = 55.8 bits (133), Expect = 8e-07
 Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)

Query: 1344 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
            L  FN  W EL +       LL+Q I+S +     L  I E +          I  K   
Sbjct: 12   LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57

Query: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1456
              + Q   +++  +T+     + +K     +EA        +R+ +Q D  Q+ LQ+   
Sbjct: 58   QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113

Query: 1457 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1515
            +   + +    + +  +E++ +L + +  L + +      + +Q ++     L K L + 
Sbjct: 114  QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 1516 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
            ++ V++      ++++    ++ +++      +   +  +  +V+ER+  LE+  +L ++
Sbjct: 174  QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1634
               ++     WL  T+ E T     +        E + G K   K+ +  +  +++ T+V
Sbjct: 234  FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291

Query: 1635 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685
                     + L+++ G  +  L++ +L  +N  W  +  ++    + L       +   
Sbjct: 292  YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351

Query: 1686 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1737
             ++  +  W+   D   DE  ++ P        Q++ DV +  K EL    P + ST + 
Sbjct: 352  LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408

Query: 1738 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                +  +  +   KL  EP+      R   ++  ++        K+ E+ N++ +KL  
Sbjct: 409  VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1848
                      NL   D+ + ++E  E  ++EL +  D L  ++   R+ E IK
Sbjct: 459  ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)

Query: 1281 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1334
            WL+ ++  +K+   + G  E+I+E++   +  M+  E    Q+  L   AQ L   T   
Sbjct: 25   WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84

Query: 1335 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1390
                +I + +E   ++W E+ E    R+    ++L+ S Q  +  E++  ++ ++   ++
Sbjct: 85   EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144

Query: 1391 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1443
              +   Y  D +     +  Q+ ++ ++ Q+++  +++++L+ ++ ++        ++++
Sbjct: 145  SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1494
               A  +    S+  R+ ++ A  E+    LQ+  + L++    L   ET       +  
Sbjct: 205  NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260

Query: 1495 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1546
            +E +         L K   +++ E+E        + +  Q        +++   L  R+ 
Sbjct: 261  KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
             +   ++EL  K    +  LE      +++   +  L  WL   D EL++++ + G    
Sbjct: 321  NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1664
            +  +    +A ++E++ ++  + S  E      T   L   E L ++   L         
Sbjct: 381  VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434

Query: 1665 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1723
             RA+    LL +  + + T  + ++ H   W  + D  L+  ++ +    E  LK  +AE
Sbjct: 435  ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 1724 L--NDIRP----KVDSTRDQAANLMANRGD 1747
            +     +P     +DS +D    + A RG+
Sbjct: 495  VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
           E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340

Query: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
           EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388

Query: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
             +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448

Query: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
             +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503

Query: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
           G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559

Query: 536 LGDRWANICRWTEDR 550
           L  RW  +    EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 984  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156


>gi|5032309 dystrophin Dp140b isoform [Homo sapiens]
          Length = 1243

 Score = 2427 bits (6289), Expect = 0.0
 Identities = 1213/1214 (99%), Positives = 1213/1214 (99%)

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3420
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960

Query: 3421 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3480
            APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961  APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020

Query: 3481 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3540
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080

Query: 3541 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3600
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140

Query: 3601 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3660
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200

Query: 3661 EQLNNSFPSSRGRN 3674
            EQLNNSFPSSRG N
Sbjct: 1201 EQLNNSFPSSRGHN 1214



 Score =  100 bits (249), Expect = 3e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 2005 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2063
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2121
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 2122 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2284
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 2285 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2344
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 2345 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2404
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 2405 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2461
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 2462 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2515
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 2516 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2575
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 2576 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2630
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 2631 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2681
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)

Query: 1060 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1119
            L  W++ +D  +K +   +GD E + + + + +  + D++  +P L  +    Q +KN+ 
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1120 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1178
              + A  + T+ ++ +  QWD + + +  R++ L   L+ +    +   E  + + QA  
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1179 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1238
            +         T D +QK + E K+  ++ +Q +  V +  +    ++      A +  K 
Sbjct: 142  KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199

Query: 1239 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1296
             + T   N  W  +  R++ +   LEE      +    LEK   WL E E    TT N+ 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255

Query: 1297 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1338
              A   E + E    ++ LM+  +D               + N  +IL     +G     
Sbjct: 256  QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313

Query: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1394
            L+   L+  N +W EL ++++     +   ++++ +  K LHL +QE L ++   D +L+
Sbjct: 314  LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1395 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1434
              A I     A Q   +  +            I S L +  I L E       K + + +
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429

Query: 1435 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            E    +R  +   + +K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K
Sbjct: 430  ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489

Query: 1492 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1536
              + EV+               Q  L     L   ++ +K  V  V    RQ+       
Sbjct: 490  LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549

Query: 1537 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1568
            +P  L   +  L   +  L   V +R +QL +
Sbjct: 550  SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)

Query: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
           SSLM     L  +  A  E+  WL   +  +++Q  +  D+E + +     +  M DL  
Sbjct: 3   SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62

Query: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
            + ++  ++     L          +T  QE   ++  R E ++    E Q +L      
Sbjct: 63  RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114

Query: 452 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 503
           L N+ LK+   WL   EE  +       K+E    GP  ++ +++++ + K L +DL Q 
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 504 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 563
           Q  V+    + + +        T  +    + +   W +I +   +R   L++     Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 564 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 618
              +   F AWL+E E   N +     K     D   +   +++   L+ ++E       
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293

Query: 619 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 657
            L    Q +L +L+        +  LDN    W  L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)

Query: 944  YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 1003
            +    + +  W+   +  +   ++ V D E + + + + +A    L++++  L  L T  
Sbjct: 15   FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74

Query: 1004 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1058
            + +  K  ++ +R   ++  E I+ +W ++   L    Q+L E +      L   +   Q
Sbjct: 75   QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 1059 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1118
             L +  A+++ +  +E P   D+  ++K++ + + L  D++  Q +++  N+   K+  +
Sbjct: 135  VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190

Query: 1119 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1177
               +   ++    + +N  W  + ++V  R+ AL+           DL +   W+T+AE 
Sbjct: 191  YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250

Query: 1178 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1233
                L+     +   E  K V+E+ +  ++ Q   +    V    +  +  I ++   + 
Sbjct: 251  TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310

Query: 1234 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1275
            +A+  +      N++W   R     +    +   + W   H    ELL +L         
Sbjct: 311  DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370

Query: 1276 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1318
                       +K N      + +LKT E +     E   +      L+ LE L +   +
Sbjct: 371  QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430

Query: 1319 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
             P + R  AQ +T       L+ ++ E  N+ W +L+  +   Q+ ++++++  QE +++
Sbjct: 431  LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)

Query: 729  TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 785
            TEL  W++  + V++S    +    G+  D+ E   K  A  ++  ++  +L++   +AQ
Sbjct: 20   TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75

Query: 786  ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 844
             L  +  N+      I    E++ ++W E  + L  R   L E   +   +    ++ EQ
Sbjct: 76   NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 845  MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 904
            +   A   L+     P    AI+ ++   K     L   Q  ++     ++ L       
Sbjct: 135  VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194

Query: 905  MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
                   +       ++ +   V  RE  L+     L   ++   +     W+ ++ET  
Sbjct: 195  DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252

Query: 963  SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
            ++ Q +     ++E   G      + Q LQ  ++      + L    +++ +    S+ +
Sbjct: 253  NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
               Q   + +  +W +L  + +     LE   ++ +++   +Q L  W+   D  L  + 
Sbjct: 313  VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1120
            P  GD   ++KQ    R    +++T +P + S              EG +K+     E  
Sbjct: 373  PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432

Query: 1121 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
            PE  ++     L  + +E+NT+W+ +       +  +   LE+   LQ+   E+   + Q
Sbjct: 433  PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492

Query: 1176 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1232
            A  E ++  ++       D LQ  +E++K  + E    +  V  + +    +      ++
Sbjct: 493  A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550

Query: 1233 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
               L   LE L T ++ L   +  + + L E
Sbjct: 551  PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)

Query: 1510 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1568
            + L + + ++E +I   + +  K   +  + +  +R+  ++  ++E+   +  R+QQL +
Sbjct: 58   QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117

Query: 1569 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1628
             LK S +  +      + L     +L            +  ++   K   K++ + + ++
Sbjct: 118  MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177

Query: 1629 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1687
                ++   L       +T     ++  +N++W ++  R  E    L E  + ++ F  +
Sbjct: 178  DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237

Query: 1688 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            ++    W+ +A+T    L D + K++  +    +K L  +  D++ ++++  D   NL  
Sbjct: 238  LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297

Query: 1744 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
            N         G     L++ ++  +N +++ +       K S+ ++   + +SD  K L 
Sbjct: 298  NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351

Query: 1796 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1842
                E+   + LK+++ ++              N+ +    +EL  +   +   +   R 
Sbjct: 352  LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411

Query: 1843 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1895
                + ++  ++L Q       + R+Q      RK+A E++ +W +    + D  + +D+
Sbjct: 412  FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471

Query: 1896 IEKKLASLPEPRDERKIKEIDRELQK 1921
              ++L  L E  DE  +K    E+ K
Sbjct: 472  TLERLQELQEATDELDLKLRQAEVIK 497



 Score = 55.8 bits (133), Expect = 8e-07
 Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)

Query: 1344 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
            L  FN  W EL +       LL+Q I+S +     L  I E +          I  K   
Sbjct: 12   LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57

Query: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1456
              + Q   +++  +T+     + +K     +EA        +R+ +Q D  Q+ LQ+   
Sbjct: 58   QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113

Query: 1457 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1515
            +   + +    + +  +E++ +L + +  L + +      + +Q ++     L K L + 
Sbjct: 114  QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 1516 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
            ++ V++      ++++    ++ +++      +   +  +  +V+ER+  LE+  +L ++
Sbjct: 174  QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1634
               ++     WL  T+ E T     +        E + G K   K+ +  +  +++ T+V
Sbjct: 234  FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291

Query: 1635 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685
                     + L+++ G  +  L++ +L  +N  W  +  ++    + L       +   
Sbjct: 292  YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351

Query: 1686 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1737
             ++  +  W+   D   DE  ++ P        Q++ DV +  K EL    P + ST + 
Sbjct: 352  LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408

Query: 1738 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                +  +  +   KL  EP+      R   ++  ++        K+ E+ N++ +KL  
Sbjct: 409  VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1848
                      NL   D+ + ++E  E  ++EL +  D L  ++   R+ E IK
Sbjct: 459  ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)

Query: 1281 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1334
            WL+ ++  +K+   + G  E+I+E++   +  M+  E    Q+  L   AQ L   T   
Sbjct: 25   WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84

Query: 1335 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1390
                +I + +E   ++W E+ E    R+    ++L+ S Q  +  E++  ++ ++   ++
Sbjct: 85   EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144

Query: 1391 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1443
              +   Y  D +     +  Q+ ++ ++ Q+++  +++++L+ ++ ++        ++++
Sbjct: 145  SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1494
               A  +    S+  R+ ++ A  E+    LQ+  + L++    L   ET       +  
Sbjct: 205  NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260

Query: 1495 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1546
            +E +         L K   +++ E+E        + +  Q        +++   L  R+ 
Sbjct: 261  KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
             +   ++EL  K    +  LE      +++   +  L  WL   D EL++++ + G    
Sbjct: 321  NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1664
            +  +    +A ++E++ ++  + S  E      T   L   E L ++   L         
Sbjct: 381  VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434

Query: 1665 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1723
             RA+    LL +  + + T  + ++ H   W  + D  L+  ++ +    E  LK  +AE
Sbjct: 435  ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 1724 L--NDIRP----KVDSTRDQAANLMANRGD 1747
            +     +P     +DS +D    + A RG+
Sbjct: 495  VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
           E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340

Query: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
           EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388

Query: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
             +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448

Query: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
             +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503

Query: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
           G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559

Query: 536 LGDRWANICRWTEDR 550
           L  RW  +    EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 984  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156


>gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]
          Length = 1230

 Score = 2390 bits (6193), Expect = 0.0
 Identities = 1200/1214 (98%), Positives = 1200/1214 (98%), Gaps = 13/1214 (1%)

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3420
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET            
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET------------ 948

Query: 3421 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3480
             PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 949  -PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1007

Query: 3481 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3540
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1008 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1067

Query: 3541 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3600
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1068 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1127

Query: 3601 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3660
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1128 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1187

Query: 3661 EQLNNSFPSSRGRN 3674
            EQLNNSFPSSRG N
Sbjct: 1188 EQLNNSFPSSRGHN 1201



 Score =  100 bits (249), Expect = 3e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 2005 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2063
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2121
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 2122 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2284
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 2285 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2344
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 2345 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2404
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 2405 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2461
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 2462 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2515
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 2516 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2575
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 2576 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2630
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 2631 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2681
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)

Query: 1060 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1119
            L  W++ +D  +K +   +GD E + + + + +  + D++  +P L  +    Q +KN+ 
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1120 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1178
              + A  + T+ ++ +  QWD + + +  R++ L   L+ +    +   E  + + QA  
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1179 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1238
            +         T D +QK + E K+  ++ +Q +  V +  +    ++      A +  K 
Sbjct: 142  KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199

Query: 1239 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1296
             + T   N  W  +  R++ +   LEE      +    LEK   WL E E    TT N+ 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255

Query: 1297 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1338
              A   E + E    ++ LM+  +D               + N  +IL     +G     
Sbjct: 256  QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313

Query: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1394
            L+   L+  N +W EL ++++     +   ++++ +  K LHL +QE L ++   D +L+
Sbjct: 314  LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1395 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1434
              A I     A Q   +  +            I S L +  I L E       K + + +
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429

Query: 1435 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            E    +R  +   + +K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K
Sbjct: 430  ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489

Query: 1492 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1536
              + EV+               Q  L     L   ++ +K  V  V    RQ+       
Sbjct: 490  LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549

Query: 1537 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1568
            +P  L   +  L   +  L   V +R +QL +
Sbjct: 550  SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)

Query: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
           SSLM     L  +  A  E+  WL   +  +++Q  +  D+E + +     +  M DL  
Sbjct: 3   SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62

Query: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
            + ++  ++     L          +T  QE   ++  R E ++    E Q +L      
Sbjct: 63  RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114

Query: 452 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 503
           L N+ LK+   WL   EE  +       K+E    GP  ++ +++++ + K L +DL Q 
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 504 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 563
           Q  V+    + + +        T  +    + +   W +I +   +R   L++     Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 564 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 618
              +   F AWL+E E   N +     K     D   +   +++   L+ ++E       
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293

Query: 619 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 657
            L    Q +L +L+        +  LDN    W  L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)

Query: 944  YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 1003
            +    + +  W+   +  +   ++ V D E + + + + +A    L++++  L  L T  
Sbjct: 15   FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74

Query: 1004 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1058
            + +  K  ++ +R   ++  E I+ +W ++   L    Q+L E +      L   +   Q
Sbjct: 75   QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 1059 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1118
             L +  A+++ +  +E P   D+  ++K++ + + L  D++  Q +++  N+   K+  +
Sbjct: 135  VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190

Query: 1119 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1177
               +   ++    + +N  W  + ++V  R+ AL+           DL +   W+T+AE 
Sbjct: 191  YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250

Query: 1178 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1233
                L+     +   E  K V+E+ +  ++ Q   +    V    +  +  I ++   + 
Sbjct: 251  TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310

Query: 1234 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1275
            +A+  +      N++W   R     +    +   + W   H    ELL +L         
Sbjct: 311  DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370

Query: 1276 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1318
                       +K N      + +LKT E +     E   +      L+ LE L +   +
Sbjct: 371  QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430

Query: 1319 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
             P + R  AQ +T       L+ ++ E  N+ W +L+  +   Q+ ++++++  QE +++
Sbjct: 431  LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)

Query: 729  TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 785
            TEL  W++  + V++S    +    G+  D+ E   K  A  ++  ++  +L++   +AQ
Sbjct: 20   TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75

Query: 786  ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 844
             L  +  N+      I    E++ ++W E  + L  R   L E   +   +    ++ EQ
Sbjct: 76   NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 845  MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 904
            +   A   L+     P    AI+ ++   K     L   Q  ++     ++ L       
Sbjct: 135  VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194

Query: 905  MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
                   +       ++ +   V  RE  L+     L   ++   +     W+ ++ET  
Sbjct: 195  DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252

Query: 963  SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
            ++ Q +     ++E   G      + Q LQ  ++      + L    +++ +    S+ +
Sbjct: 253  NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
               Q   + +  +W +L  + +     LE   ++ +++   +Q L  W+   D  L  + 
Sbjct: 313  VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1120
            P  GD   ++KQ    R    +++T +P + S              EG +K+     E  
Sbjct: 373  PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432

Query: 1121 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
            PE  ++     L  + +E+NT+W+ +       +  +   LE+   LQ+   E+   + Q
Sbjct: 433  PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492

Query: 1176 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1232
            A  E ++  ++       D LQ  +E++K  + E    +  V  + +    +      ++
Sbjct: 493  A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550

Query: 1233 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
               L   LE L T ++ L   +  + + L E
Sbjct: 551  PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)

Query: 1510 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1568
            + L + + ++E +I   + +  K   +  + +  +R+  ++  ++E+   +  R+QQL +
Sbjct: 58   QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117

Query: 1569 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1628
             LK S +  +      + L     +L            +  ++   K   K++ + + ++
Sbjct: 118  MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177

Query: 1629 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1687
                ++   L       +T     ++  +N++W ++  R  E    L E  + ++ F  +
Sbjct: 178  DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237

Query: 1688 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            ++    W+ +A+T    L D + K++  +    +K L  +  D++ ++++  D   NL  
Sbjct: 238  LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297

Query: 1744 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
            N         G     L++ ++  +N +++ +       K S+ ++   + +SD  K L 
Sbjct: 298  NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351

Query: 1796 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1842
                E+   + LK+++ ++              N+ +    +EL  +   +   +   R 
Sbjct: 352  LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411

Query: 1843 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1895
                + ++  ++L Q       + R+Q      RK+A E++ +W +    + D  + +D+
Sbjct: 412  FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471

Query: 1896 IEKKLASLPEPRDERKIKEIDRELQK 1921
              ++L  L E  DE  +K    E+ K
Sbjct: 472  TLERLQELQEATDELDLKLRQAEVIK 497



 Score = 55.8 bits (133), Expect = 8e-07
 Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)

Query: 1344 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
            L  FN  W EL +       LL+Q I+S +     L  I E +          I  K   
Sbjct: 12   LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57

Query: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1456
              + Q   +++  +T+     + +K     +EA        +R+ +Q D  Q+ LQ+   
Sbjct: 58   QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113

Query: 1457 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1515
            +   + +    + +  +E++ +L + +  L + +      + +Q ++     L K L + 
Sbjct: 114  QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 1516 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
            ++ V++      ++++    ++ +++      +   +  +  +V+ER+  LE+  +L ++
Sbjct: 174  QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1634
               ++     WL  T+ E T     +        E + G K   K+ +  +  +++ T+V
Sbjct: 234  FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291

Query: 1635 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685
                     + L+++ G  +  L++ +L  +N  W  +  ++    + L       +   
Sbjct: 292  YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351

Query: 1686 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1737
             ++  +  W+   D   DE  ++ P        Q++ DV +  K EL    P + ST + 
Sbjct: 352  LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408

Query: 1738 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                +  +  +   KL  EP+      R   ++  ++        K+ E+ N++ +KL  
Sbjct: 409  VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1848
                      NL   D+ + ++E  E  ++EL +  D L  ++   R+ E IK
Sbjct: 459  ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)

Query: 1281 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1334
            WL+ ++  +K+   + G  E+I+E++   +  M+  E    Q+  L   AQ L   T   
Sbjct: 25   WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84

Query: 1335 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1390
                +I + +E   ++W E+ E    R+    ++L+ S Q  +  E++  ++ ++   ++
Sbjct: 85   EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144

Query: 1391 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1443
              +   Y  D +     +  Q+ ++ ++ Q+++  +++++L+ ++ ++        ++++
Sbjct: 145  SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1494
               A  +    S+  R+ ++ A  E+    LQ+  + L++    L   ET       +  
Sbjct: 205  NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260

Query: 1495 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1546
            +E +         L K   +++ E+E        + +  Q        +++   L  R+ 
Sbjct: 261  KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
             +   ++EL  K    +  LE      +++   +  L  WL   D EL++++ + G    
Sbjct: 321  NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1664
            +  +    +A ++E++ ++  + S  E      T   L   E L ++   L         
Sbjct: 381  VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434

Query: 1665 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1723
             RA+    LL +  + + T  + ++ H   W  + D  L+  ++ +    E  LK  +AE
Sbjct: 435  ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 1724 L--NDIRP----KVDSTRDQAANLMANRGD 1747
            +     +P     +DS +D    + A RG+
Sbjct: 495  VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
           E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340

Query: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
           EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388

Query: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
             +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448

Query: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
             +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503

Query: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
           G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559

Query: 536 LGDRWANICRWTEDR 550
           L  RW  +    EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 971  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1029

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 1030 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1085

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 1086 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1143


>gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]
          Length = 1133

 Score = 1908 bits (4943), Expect = 0.0
 Identities = 970/1073 (90%), Positives = 988/1073 (92%), Gaps = 52/1073 (4%)

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3420
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET +          
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETNL---------- 950

Query: 3421 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3480
                  Q  +D    + EH               L+   SP E +               
Sbjct: 951  ------QAEYDRLKQQHEHKG-------------LSPLPSPPEMMP-------------- 977

Query: 3481 QDSPLSQPRSPAQILISLES----EERGELERILADLEEENRNLQAEYDRLKQ 3529
                 + P+SP    +  E+    + +G LE  +  LE+ N+ L+++  RL+Q
Sbjct: 978  -----TSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQ 1025



 Score =  306 bits (785), Expect = 2e-82
 Identities = 158/164 (96%), Positives = 159/164 (96%), Gaps = 2/164 (1%)

Query: 3513 LEEENR--NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 3570
            LE +N   NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
Sbjct: 941  LEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 1000

Query: 3571 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 3630
            RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
Sbjct: 1001 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 1060

Query: 3631 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 3674
            VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 1061 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 1104



 Score =  100 bits (249), Expect = 3e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 2005 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2063
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2121
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 2122 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2284
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 2285 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2344
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 2345 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2404
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 2405 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2461
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 2462 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2515
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 2516 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2575
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 2576 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2630
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 2631 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2681
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)

Query: 1060 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1119
            L  W++ +D  +K +   +GD E + + + + +  + D++  +P L  +    Q +KN+ 
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1120 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1178
              + A  + T+ ++ +  QWD + + +  R++ L   L+ +    +   E  + + QA  
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1179 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1238
            +         T D +QK + E K+  ++ +Q +  V +  +    ++      A +  K 
Sbjct: 142  KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199

Query: 1239 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1296
             + T   N  W  +  R++ +   LEE      +    LEK   WL E E    TT N+ 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255

Query: 1297 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1338
              A   E + E    ++ LM+  +D               + N  +IL     +G     
Sbjct: 256  QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313

Query: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1394
            L+   L+  N +W EL ++++     +   ++++ +  K LHL +QE L ++   D +L+
Sbjct: 314  LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1395 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1434
              A I     A Q   +  +            I S L +  I L E       K + + +
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429

Query: 1435 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            E    +R  +   + +K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K
Sbjct: 430  ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489

Query: 1492 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1536
              + EV+               Q  L     L   ++ +K  V  V    RQ+       
Sbjct: 490  LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549

Query: 1537 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1568
            +P  L   +  L   +  L   V +R +QL +
Sbjct: 550  SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)

Query: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
           SSLM     L  +  A  E+  WL   +  +++Q  +  D+E + +     +  M DL  
Sbjct: 3   SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62

Query: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
            + ++  ++     L          +T  QE   ++  R E ++    E Q +L      
Sbjct: 63  RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114

Query: 452 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 503
           L N+ LK+   WL   EE  +       K+E    GP  ++ +++++ + K L +DL Q 
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 504 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 563
           Q  V+    + + +        T  +    + +   W +I +   +R   L++     Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 564 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 618
              +   F AWL+E E   N +     K     D   +   +++   L+ ++E       
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293

Query: 619 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 657
            L    Q +L +L+        +  LDN    W  L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)

Query: 944  YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 1003
            +    + +  W+   +  +   ++ V D E + + + + +A    L++++  L  L T  
Sbjct: 15   FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74

Query: 1004 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1058
            + +  K  ++ +R   ++  E I+ +W ++   L    Q+L E +      L   +   Q
Sbjct: 75   QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 1059 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1118
             L +  A+++ +  +E P   D+  ++K++ + + L  D++  Q +++  N+   K+  +
Sbjct: 135  VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190

Query: 1119 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1177
               +   ++    + +N  W  + ++V  R+ AL+           DL +   W+T+AE 
Sbjct: 191  YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250

Query: 1178 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1233
                L+     +   E  K V+E+ +  ++ Q   +    V    +  +  I ++   + 
Sbjct: 251  TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310

Query: 1234 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1275
            +A+  +      N++W   R     +    +   + W   H    ELL +L         
Sbjct: 311  DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370

Query: 1276 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1318
                       +K N      + +LKT E +     E   +      L+ LE L +   +
Sbjct: 371  QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430

Query: 1319 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
             P + R  AQ +T       L+ ++ E  N+ W +L+  +   Q+ ++++++  QE +++
Sbjct: 431  LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)

Query: 729  TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 785
            TEL  W++  + V++S    +    G+  D+ E   K  A  ++  ++  +L++   +AQ
Sbjct: 20   TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75

Query: 786  ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 844
             L  +  N+      I    E++ ++W E  + L  R   L E   +   +    ++ EQ
Sbjct: 76   NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 845  MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 904
            +   A   L+     P    AI+ ++   K     L   Q  ++     ++ L       
Sbjct: 135  VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194

Query: 905  MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
                   +       ++ +   V  RE  L+     L   ++   +     W+ ++ET  
Sbjct: 195  DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252

Query: 963  SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
            ++ Q +     ++E   G      + Q LQ  ++      + L    +++ +    S+ +
Sbjct: 253  NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
               Q   + +  +W +L  + +     LE   ++ +++   +Q L  W+   D  L  + 
Sbjct: 313  VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1120
            P  GD   ++KQ    R    +++T +P + S              EG +K+     E  
Sbjct: 373  PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432

Query: 1121 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
            PE  ++     L  + +E+NT+W+ +       +  +   LE+   LQ+   E+   + Q
Sbjct: 433  PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492

Query: 1176 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1232
            A  E ++  ++       D LQ  +E++K  + E    +  V  + +    +      ++
Sbjct: 493  A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550

Query: 1233 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
               L   LE L T ++ L   +  + + L E
Sbjct: 551  PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)

Query: 1510 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1568
            + L + + ++E +I   + +  K   +  + +  +R+  ++  ++E+   +  R+QQL +
Sbjct: 58   QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117

Query: 1569 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1628
             LK S +  +      + L     +L            +  ++   K   K++ + + ++
Sbjct: 118  MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177

Query: 1629 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1687
                ++   L       +T     ++  +N++W ++  R  E    L E  + ++ F  +
Sbjct: 178  DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237

Query: 1688 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            ++    W+ +A+T    L D + K++  +    +K L  +  D++ ++++  D   NL  
Sbjct: 238  LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297

Query: 1744 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
            N         G     L++ ++  +N +++ +       K S+ ++   + +SD  K L 
Sbjct: 298  NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351

Query: 1796 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1842
                E+   + LK+++ ++              N+ +    +EL  +   +   +   R 
Sbjct: 352  LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411

Query: 1843 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1895
                + ++  ++L Q       + R+Q      RK+A E++ +W +    + D  + +D+
Sbjct: 412  FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471

Query: 1896 IEKKLASLPEPRDERKIKEIDRELQK 1921
              ++L  L E  DE  +K    E+ K
Sbjct: 472  TLERLQELQEATDELDLKLRQAEVIK 497



 Score = 55.8 bits (133), Expect = 8e-07
 Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)

Query: 1344 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
            L  FN  W EL +       LL+Q I+S +     L  I E +          I  K   
Sbjct: 12   LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57

Query: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1456
              + Q   +++  +T+     + +K     +EA        +R+ +Q D  Q+ LQ+   
Sbjct: 58   QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113

Query: 1457 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1515
            +   + +    + +  +E++ +L + +  L + +      + +Q ++     L K L + 
Sbjct: 114  QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 1516 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
            ++ V++      ++++    ++ +++      +   +  +  +V+ER+  LE+  +L ++
Sbjct: 174  QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1634
               ++     WL  T+ E T     +        E + G K   K+ +  +  +++ T+V
Sbjct: 234  FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291

Query: 1635 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685
                     + L+++ G  +  L++ +L  +N  W  +  ++    + L       +   
Sbjct: 292  YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351

Query: 1686 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1737
             ++  +  W+   D   DE  ++ P        Q++ DV +  K EL    P + ST + 
Sbjct: 352  LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408

Query: 1738 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                +  +  +   KL  EP+      R   ++  ++        K+ E+ N++ +KL  
Sbjct: 409  VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1848
                      NL   D+ + ++E  E  ++EL +  D L  ++   R+ E IK
Sbjct: 459  ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)

Query: 1281 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1334
            WL+ ++  +K+   + G  E+I+E++   +  M+  E    Q+  L   AQ L   T   
Sbjct: 25   WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84

Query: 1335 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1390
                +I + +E   ++W E+ E    R+    ++L+ S Q  +  E++  ++ ++   ++
Sbjct: 85   EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144

Query: 1391 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1443
              +   Y  D +     +  Q+ ++ ++ Q+++  +++++L+ ++ ++        ++++
Sbjct: 145  SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1494
               A  +    S+  R+ ++ A  E+    LQ+  + L++    L   ET       +  
Sbjct: 205  NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260

Query: 1495 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1546
            +E +         L K   +++ E+E        + +  Q        +++   L  R+ 
Sbjct: 261  KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
             +   ++EL  K    +  LE      +++   +  L  WL   D EL++++ + G    
Sbjct: 321  NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1664
            +  +    +A ++E++ ++  + S  E      T   L   E L ++   L         
Sbjct: 381  VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434

Query: 1665 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1723
             RA+    LL +  + + T  + ++ H   W  + D  L+  ++ +    E  LK  +AE
Sbjct: 435  ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 1724 L--NDIRP----KVDSTRDQAANLMANRGD 1747
            +     +P     +DS +D    + A RG+
Sbjct: 495  VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
           E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340

Query: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
           EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388

Query: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
             +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448

Query: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
             +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503

Query: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
           G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559

Query: 536 LGDRWANICRWTEDR 550
           L  RW  +    EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574


>gi|5032295 dystrophin Dp116 isoform [Homo sapiens]
          Length = 956

 Score = 1907 bits (4939), Expect = 0.0
 Identities = 946/947 (99%), Positives = 947/947 (100%)

Query: 2739 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2798
            +DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS
Sbjct: 10   KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69

Query: 2799 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2858
            HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK
Sbjct: 70   HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 129

Query: 2859 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2918
            EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL
Sbjct: 130  EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 189

Query: 2919 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2978
            NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV
Sbjct: 190  NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 249

Query: 2979 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 3038
            KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL
Sbjct: 250  KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 309

Query: 3039 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 3098
            HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL
Sbjct: 310  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 369

Query: 3099 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 3158
            NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY
Sbjct: 370  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 429

Query: 3159 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 3218
            DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL
Sbjct: 430  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 489

Query: 3219 FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 3278
            FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA
Sbjct: 490  FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 549

Query: 3279 ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 3338
            ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ
Sbjct: 550  ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 609

Query: 3339 SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 3398
            SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ
Sbjct: 610  SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 669

Query: 3399 TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 3458
            TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS
Sbjct: 670  TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 729

Query: 3459 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 3518
            ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR
Sbjct: 730  ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 789

Query: 3519 NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 3578
            NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI
Sbjct: 790  NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 849

Query: 3579 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 3638
            LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD
Sbjct: 850  LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 909

Query: 3639 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3685
            SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 910  SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 956



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 33/235 (14%)

Query: 2481 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ-------------- 2526
            EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P               
Sbjct: 87   ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 146

Query: 2527 -----LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD 2581
                 LE+L    + L  +   Q    ++  + E +  +W+++  H  + +++++E L+ 
Sbjct: 147  QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 206

Query: 2582 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
              +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++   + NV   
Sbjct: 207  LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 266

Query: 2641 NDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 2689
            NDLA +L      L  Y+           E++N  W+ +   V +R   L E HR
Sbjct: 267  NDLARQLTTLGIQLSPYNLSTL-------EDLNTRWKLLQVAVEDRVRQLHEAHR 314



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 79/375 (21%), Positives = 152/375 (40%), Gaps = 34/375 (9%)

Query: 2143 WYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRWQEVCKQLSD 2201
            +++K+LQ  I     V   L+   ++I++      DA +LQ +L ++N +W E+ K+  +
Sbjct: 7    YHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 66

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV-KLLVEEL 2260
             +  LE   +        L E ++WL+  D+  S     G +    +K   V +    EL
Sbjct: 67   IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 126

Query: 2261 PLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LENKLKQTNLQW 2302
              ++ ++    ET    L   P+              PEE+ +     L  + ++ N +W
Sbjct: 127  KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 186

Query: 2303 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2362
             K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++     Q+  
Sbjct: 187  EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHL 246

Query: 2363 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK----AVNRLL 2417
              V+     +   + +V  +    + L        P     LEDL++ WK    AV   +
Sbjct: 247  EKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRV 306

Query: 2418 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNR 2477
            ++L     D  P      AS     T V  P    E AIS  ++P  +  E       + 
Sbjct: 307  RQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHETQTTCWDHP 357

Query: 2478 AWTELTDWLSLLDQV 2492
              TEL   L+ L+ V
Sbjct: 358  KMTELYQSLADLNNV 372



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 62/314 (19%), Positives = 132/314 (42%), Gaps = 33/314 (10%)

Query: 2040 NIKDSLQQSSGRIDIIHSKKTAALQSATPVE----RVKLQEALSQLDFQWEKVNKMYKDR 2095
            ++KD   +     D+ H+    + +    +E     V LQ  L  ++F+W ++ K   + 
Sbjct: 8    HVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 67

Query: 2096 QGRFDRSVEKWRRFHYDIKIFNQWL-TEAEQFLRKTQI--------PENWEHAKYKWYLK 2146
            +   + S ++W+R H  ++    WL  + ++  R+  I         +N  H  +K  LK
Sbjct: 68   RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 127

Query: 2147 ELQDGIGQRQTVVRTLNATG-----EEIIQ--------QSSKTDASILQEKLGSLNLRWQ 2193
              +  I      VR           E++ Q        + ++    +L+++   +N  W+
Sbjct: 128  TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 187

Query: 2194 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLE 2251
            ++    +D +++++E    L E Q   +E  L L +A+ I     P+       L++ LE
Sbjct: 188  KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 247

Query: 2252 QVKLLVEEL-PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 2310
            +VK L  E+ PL++ +    +       +   +SP     LE+     N +W  +  A+ 
Sbjct: 248  KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 303

Query: 2311 EKQGEIEAQIKDLG 2324
            ++  ++    +D G
Sbjct: 304  DRVRQLHEAHRDFG 317



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 64/312 (20%), Positives = 130/312 (41%), Gaps = 26/312 (8%)

Query: 1083 ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE-PEFASRLETELKELNTQWDHM 1141
            +L ++    + L  +I+      ++++E  QKI    E  + A  L+  L  +N +W  +
Sbjct: 1    MLHRKTYHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL 60

Query: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
             ++    +  L+   ++   L   L E+  W+   ++E   +         +QK  +  +
Sbjct: 61   RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHR 120

Query: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE---------LETLTTNYQWLCT 1252
              K E + KE  +    E+V   + + P    E L +E          + +T   +    
Sbjct: 121  AFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAE 180

Query: 1253 RLNGKCKTLEEVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL-D 1307
             +N + + L    A W     E L  L++  +  +E++ KL+  E I G  + + ++L D
Sbjct: 181  EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 240

Query: 1308 SLENLMRH----------SEDNPNQIRILAQTLTDGGVMDELIN-EELETFNSRWRELHE 1356
            SL++ +             ++N + +  LA+ LT  G+     N   LE  N+RW+ L  
Sbjct: 241  SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQV 300

Query: 1357 EAVRRQKLLEQS 1368
                R + L ++
Sbjct: 301  AVEDRVRQLHEA 312



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 38/164 (23%), Positives = 85/164 (51%), Gaps = 6/164 (3%)

Query: 979  LGELQALQSSLQEQQ-SGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQL 1036
            +  L+ ++  L EQ   GL  L    +E+  +  ++ ++R  + + EE+   W+KL+   
Sbjct: 134  MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 193

Query: 1037 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI--LKKQLKQCRLL 1094
             +  +K++E + +L+++Q     L   + + +V +K  W  +GD  I  L+  L++ + L
Sbjct: 194  ADWQRKIDETLERLQELQEATDELDLKLRQAEV-IKGSWQPVGDLLIDSLQDHLEKVKAL 252

Query: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1138
              +I  ++ +++ VN+  +++           L T L++LNT+W
Sbjct: 253  RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST-LEDLNTRW 295



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
           E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 17  EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 71

Query: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
           EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 72  EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 119

Query: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
             +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 120 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 179

Query: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
             +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 180 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 234

Query: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
           G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 235 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 290

Query: 536 LGDRWANICRWTEDR 550
           L  RW  +    EDR
Sbjct: 291 LNTRWKLLQVAVEDR 305



 Score = 42.4 bits (98), Expect = 0.009
 Identities = 53/268 (19%), Positives = 109/268 (40%), Gaps = 26/268 (9%)

Query: 1019 QSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPAL 1078
            Q   + +  +W +L  + +     LE   ++ +++   +Q L  W+   D  L  + P  
Sbjct: 47   QRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG 106

Query: 1079 GDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAEPEF 1123
            GD   ++KQ    R    +++T +P + S              EG +K+     E  PE 
Sbjct: 107  GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEE 166

Query: 1124 ASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1178
             ++     L  + +E+NT+W+ +       +  +   LE+   LQ+   E+   + QA  
Sbjct: 167  RAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA-- 224

Query: 1179 EYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1235
            E ++  ++       D LQ  +E++K  + E    +  V  + +    +      ++   
Sbjct: 225  EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 284

Query: 1236 LKKELETLTTNYQWLCTRLNGKCKTLEE 1263
            L   LE L T ++ L   +  + + L E
Sbjct: 285  L-STLEDLNTRWKLLQVAVEDRVRQLHE 311



 Score = 40.0 bits (92), Expect = 0.043
 Identities = 70/329 (21%), Positives = 138/329 (41%), Gaps = 52/329 (15%)

Query: 2628 KDLR-QWQTNVDVANDL---ALKLLRDYS-ADDTRKVHMITENINASWRSIHKRVSEREA 2682
            KDL+ + + + DV ++L   + K+LR    +DD   +    +N+N  W  + K+     +
Sbjct: 10   KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69

Query: 2683 ALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2742
             LE +    ++  L L++ L WL   +       + +R+  +  D   V++     +  +
Sbjct: 70   HLEASSDQWKRLHLSLQELLVWLQLKD------DELSRQAPIGGDFPAVQKQNDVHRAFK 123

Query: 2743 GEIEAHTDVYHNLDENSQKIL--RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN--IRS 2798
             E++    V  +  E  +  L  + LEG +      R L        E R +++   +R 
Sbjct: 124  RELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP------PEERAQNVTRLLRK 177

Query: 2799 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2858
              E  + +W++L+L   +   W +  D+ L R          +Q+  D     + +LK +
Sbjct: 178  QAEEVNTEWEKLNLHSAD---WQRKIDETLER-------LQELQEATD-----ELDLKLR 222

Query: 2859 E-PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP-EERAQNVTRLLRK---------- 2906
            +  VI  + + V   L +   + LEK+     E+ P +E   +V  L R+          
Sbjct: 223  QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 282

Query: 2907 ----QAEEVNTEWEKLNLHSADWQRKIDE 2931
                  E++NT W+ L +   D  R++ E
Sbjct: 283  YNLSTLEDLNTRWKLLQVAVEDRVRQLHE 311



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 715  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 773

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 774  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 829

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 830  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 887


>gi|5032307 dystrophin Dp140c isoform [Homo sapiens]
          Length = 1105

 Score = 1888 bits (4891), Expect = 0.0
 Identities = 947/975 (97%), Positives = 952/975 (97%), Gaps = 4/975 (0%)

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2880
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 2881 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2940
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 2941 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 3000
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 3001 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3060
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 3061 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3120
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 3121 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3180
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 3181 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3240
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 3241 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3300
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 3301 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3360
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 3361 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTV-LEGDNMETPVTLINFWPVD 3419
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ +  E D ++         P+ 
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQNLQAEYDRLKQQHEHKGLSPLP 960

Query: 3420 SAP---ASSPQLSHD 3431
            S P    +SPQ   D
Sbjct: 961  SPPEMMPTSPQSPRD 975



 Score =  332 bits (851), Expect = 4e-90
 Identities = 167/168 (99%), Positives = 168/168 (100%)

Query: 3518 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3577
            +NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 938  QNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 997

Query: 3578 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3637
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 998  ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 1057

Query: 3638 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3685
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1058 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 1105



 Score =  100 bits (249), Expect = 3e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 2005 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2063
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2121
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 2122 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2284
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 2285 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2344
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 2345 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2404
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 2405 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2461
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 2462 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2515
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 2516 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2575
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 2576 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2630
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 2631 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2681
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)

Query: 1060 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1119
            L  W++ +D  +K +   +GD E + + + + +  + D++  +P L  +    Q +KN+ 
Sbjct: 22   LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 1120 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1178
              + A  + T+ ++ +  QWD + + +  R++ L   L+ +    +   E  + + QA  
Sbjct: 82   SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 1179 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1238
            +         T D +QK + E K+  ++ +Q +  V +  +    ++      A +  K 
Sbjct: 142  KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199

Query: 1239 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1296
             + T   N  W  +  R++ +   LEE      +    LEK   WL E E    TT N+ 
Sbjct: 200  HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255

Query: 1297 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1338
              A   E + E    ++ LM+  +D               + N  +IL     +G     
Sbjct: 256  QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313

Query: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1394
            L+   L+  N +W EL ++++     +   ++++ +  K LHL +QE L ++   D +L+
Sbjct: 314  LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369

Query: 1395 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1434
              A I     A Q   +  +            I S L +  I L E       K + + +
Sbjct: 370  RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429

Query: 1435 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            E    +R  +   + +K+ ++V+ ++ +L    A++++++ E+   L E++     L+ K
Sbjct: 430  ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489

Query: 1492 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1536
              + EV+               Q  L     L   ++ +K  V  V    RQ+       
Sbjct: 490  LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549

Query: 1537 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1568
            +P  L   +  L   +  L   V +R +QL +
Sbjct: 550  SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)

Query: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
           SSLM     L  +  A  E+  WL   +  +++Q  +  D+E + +     +  M DL  
Sbjct: 3   SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62

Query: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
            + ++  ++     L          +T  QE   ++  R E ++    E Q +L      
Sbjct: 63  RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114

Query: 452 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 503
           L N+ LK+   WL   EE  +       K+E    GP  ++ +++++ + K L +DL Q 
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 504 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 563
           Q  V+    + + +        T  +    + +   W +I +   +R   L++     Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 564 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 618
              +   F AWL+E E   N +     K     D   +   +++   L+ ++E       
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293

Query: 619 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 657
            L    Q +L +L+        +  LDN    W  L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332



 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)

Query: 944  YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 1003
            +    + +  W+   +  +   ++ V D E + + + + +A    L++++  L  L T  
Sbjct: 15   FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74

Query: 1004 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1058
            + +  K  ++ +R   ++  E I+ +W ++   L    Q+L E +      L   +   Q
Sbjct: 75   QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 1059 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1118
             L +  A+++ +  +E P   D+  ++K++ + + L  D++  Q +++  N+   K+  +
Sbjct: 135  VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190

Query: 1119 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1177
               +   ++    + +N  W  + ++V  R+ AL+           DL +   W+T+AE 
Sbjct: 191  YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250

Query: 1178 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1233
                L+     +   E  K V+E+ +  ++ Q   +    V    +  +  I ++   + 
Sbjct: 251  TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310

Query: 1234 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1275
            +A+  +      N++W   R     +    +   + W   H    ELL +L         
Sbjct: 311  DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370

Query: 1276 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1318
                       +K N      + +LKT E +     E   +      L+ LE L +   +
Sbjct: 371  QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430

Query: 1319 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
             P + R  AQ +T       L+ ++ E  N+ W +L+  +   Q+ ++++++  QE +++
Sbjct: 431  LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)

Query: 729  TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 785
            TEL  W++  + V++S    +    G+  D+ E   K  A  ++  ++  +L++   +AQ
Sbjct: 20   TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75

Query: 786  ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 844
             L  +  N+      I    E++ ++W E  + L  R   L E   +   +    ++ EQ
Sbjct: 76   NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134

Query: 845  MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 904
            +   A   L+     P    AI+ ++   K     L   Q  ++     ++ L       
Sbjct: 135  VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194

Query: 905  MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
                   +       ++ +   V  RE  L+     L   ++   +     W+ ++ET  
Sbjct: 195  DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252

Query: 963  SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
            ++ Q +     ++E   G      + Q LQ  ++      + L    +++ +    S+ +
Sbjct: 253  NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
               Q   + +  +W +L  + +     LE   ++ +++   +Q L  W+   D  L  + 
Sbjct: 313  VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1120
            P  GD   ++KQ    R    +++T +P + S              EG +K+     E  
Sbjct: 373  PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432

Query: 1121 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
            PE  ++     L  + +E+NT+W+ +       +  +   LE+   LQ+   E+   + Q
Sbjct: 433  PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492

Query: 1176 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1232
            A  E ++  ++       D LQ  +E++K  + E    +  V  + +    +      ++
Sbjct: 493  A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550

Query: 1233 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1263
               L   LE L T ++ L   +  + + L E
Sbjct: 551  PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)

Query: 1510 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1568
            + L + + ++E +I   + +  K   +  + +  +R+  ++  ++E+   +  R+QQL +
Sbjct: 58   QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117

Query: 1569 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1628
             LK S +  +      + L     +L            +  ++   K   K++ + + ++
Sbjct: 118  MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177

Query: 1629 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1687
                ++   L       +T     ++  +N++W ++  R  E    L E  + ++ F  +
Sbjct: 178  DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237

Query: 1688 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1743
            ++    W+ +A+T    L D + K++  +    +K L  +  D++ ++++  D   NL  
Sbjct: 238  LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297

Query: 1744 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
            N         G     L++ ++  +N +++ +       K S+ ++   + +SD  K L 
Sbjct: 298  NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351

Query: 1796 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1842
                E+   + LK+++ ++              N+ +    +EL  +   +   +   R 
Sbjct: 352  LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411

Query: 1843 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1895
                + ++  ++L Q       + R+Q      RK+A E++ +W +    + D  + +D+
Sbjct: 412  FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471

Query: 1896 IEKKLASLPEPRDERKIKEIDRELQK 1921
              ++L  L E  DE  +K    E+ K
Sbjct: 472  TLERLQELQEATDELDLKLRQAEVIK 497



 Score = 55.8 bits (133), Expect = 8e-07
 Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)

Query: 1344 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
            L  FN  W EL +       LL+Q I+S +     L  I E +          I  K   
Sbjct: 12   LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57

Query: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1456
              + Q   +++  +T+     + +K     +EA        +R+ +Q D  Q+ LQ+   
Sbjct: 58   QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113

Query: 1457 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1515
            +   + +    + +  +E++ +L + +  L + +      + +Q ++     L K L + 
Sbjct: 114  QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173

Query: 1516 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
            ++ V++      ++++    ++ +++      +   +  +  +V+ER+  LE+  +L ++
Sbjct: 174  QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233

Query: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1634
               ++     WL  T+ E T     +        E + G K   K+ +  +  +++ T+V
Sbjct: 234  FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291

Query: 1635 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685
                     + L+++ G  +  L++ +L  +N  W  +  ++    + L       +   
Sbjct: 292  YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351

Query: 1686 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1737
             ++  +  W+   D   DE  ++ P        Q++ DV +  K EL    P + ST + 
Sbjct: 352  LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408

Query: 1738 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                +  +  +   KL  EP+      R   ++  ++        K+ E+ N++ +KL  
Sbjct: 409  VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1848
                      NL   D+ + ++E  E  ++EL +  D L  ++   R+ E IK
Sbjct: 459  ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)

Query: 1281 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1334
            WL+ ++  +K+   + G  E+I+E++   +  M+  E    Q+  L   AQ L   T   
Sbjct: 25   WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84

Query: 1335 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1390
                +I + +E   ++W E+ E    R+    ++L+ S Q  +  E++  ++ ++   ++
Sbjct: 85   EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144

Query: 1391 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1443
              +   Y  D +     +  Q+ ++ ++ Q+++  +++++L+ ++ ++        ++++
Sbjct: 145  SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1494
               A  +    S+  R+ ++ A  E+    LQ+  + L++    L   ET       +  
Sbjct: 205  NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260

Query: 1495 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1546
            +E +         L K   +++ E+E        + +  Q        +++   L  R+ 
Sbjct: 261  KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
             +   ++EL  K    +  LE      +++   +  L  WL   D EL++++ + G    
Sbjct: 321  NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1664
            +  +    +A ++E++ ++  + S  E      T   L   E L ++   L         
Sbjct: 381  VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434

Query: 1665 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1723
             RA+    LL +  + + T  + ++ H   W  + D  L+  ++ +    E  LK  +AE
Sbjct: 435  ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 1724 L--NDIRP----KVDSTRDQAANLMANRGD 1747
            +     +P     +DS +D    + A RG+
Sbjct: 495  VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 263 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322
           E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340

Query: 323 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
           EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388

Query: 383 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424
             +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448

Query: 425 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479
             +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503

Query: 480 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
           G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559

Query: 536 LGDRWANICRWTEDR 550
           L  RW  +    EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score = 1740 bits (4507), Expect = 0.0
 Identities = 1057/2920 (36%), Positives = 1659/2920 (56%), Gaps = 260/2920 (8%)

Query: 12   EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
            E  DVQKKTFTKW+NA+FSK GK  I ++F+DL+DGR+LLDLLEGLTG  LPKE+GSTRV
Sbjct: 28   EHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRV 87

Query: 72   HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
            HALNNVN+ L+VL  NNV+LVNIG TDIVDGNHKLTLGL+W+IILHWQVK+VMK++M+ L
Sbjct: 88   HALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDL 147

Query: 132  QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
            QQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W+ VV + S
Sbjct: 148  QQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVV-KMS 206

Query: 192  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 251
              +RLEHAF+ A+  LGIEKLLDPEDV    PDKKSI+MY+TSLF+VLPQQV+I+AI+EV
Sbjct: 207  PIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREV 266

Query: 252  EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 311
            E LPR  K   EE           + I +      E   SP+                  
Sbjct: 267  ETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA----------------- 298

Query: 312  PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 371
                       E P      S++ E +++LD YQ ALEEVL+WLLSAEDT Q Q +IS+D
Sbjct: 299  -----------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDD 341

Query: 372  VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 431
            VE VKDQF THE +MM+LTAHQ  VG++LQ G++LI  G LS++EE E+QEQM LLN+RW
Sbjct: 342  VEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARW 401

Query: 432  ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 491
            E LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME  PL  D++ L++ ++
Sbjct: 402  EALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461

Query: 492  QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 551
            +HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW  +CRWTE+RW
Sbjct: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521

Query: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
              LQ+I + WQ L EEQCL  AWL+EKE+A+NK+ T+ FKDQ E+  S+++LA+LK D+E
Sbjct: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581

Query: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
             K+Q++ +L  + QD+   L N   ++K  +  +   + WD+LVQ+LE S+ Q++QAV  
Sbjct: 582  MKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAV-- 639

Query: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
             +  ++Q    + + TV  REQ + K +++ELPPPPP KKRQI VD E +K+ D    EL
Sbjct: 640  AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAEL 699

Query: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
             +WI + +  +Q+ E   + K  + S++K+K+ A+E+E+ E+  +  + +++ Q LVEQM
Sbjct: 700  LNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQM 759

Query: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851
              EG+  + IK   E+++S W    Q L +    ++ Q +I A++ QL +LE++  T E 
Sbjct: 760  GKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEE 819

Query: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
            W+K    + S   ++ S    C+ E+  L GL P+IE  +    AL  +   P F+   F
Sbjct: 820  WVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGF 879

Query: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971
             +F   ++ V   V+ R++ L+      P   Y ET+  ++  +  SE K  +    + D
Sbjct: 880  DSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLND 939

Query: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
               +E+ L E + L   L+ Q+  L+ L+   K + K    ++ + Y+ EF++++G+W K
Sbjct: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999

Query: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
            L   + +    LEE    LR  +     ++KWM  V  FL ++  A GD   L++QL QC
Sbjct: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059

Query: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
               V++I+TI+ SL ++ E    +++       + ++T L +  TQ + + +++  +K  
Sbjct: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119

Query: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
            L    EK  +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRAKE+  QKE
Sbjct: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKE 1179

Query: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271
             +VK+L +++  + A+ P   QE L  EL  +  NYQ LC R+ GKC TLEEVW+CW EL
Sbjct: 1180 VRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL 1238

Query: 1272 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1331
            L YL+    WLN +E ++K+TE +P   + ++E L+SLE+++RH  DN  QIR L QTL 
Sbjct: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
            DGG++D++I+E+LE FNSR+ +L   A  +Q  LE+ +Q  +ET++ L ++QESL  +DK
Sbjct: 1299 DGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDK 1358

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAAQRVLSQID 1445
            QL  Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ +       +    R  SQ+D
Sbjct: 1359 QLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMD 1418

Query: 1446 VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHC 1505
            V Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK  L  L+ K V+ +V+Q+ L+ C
Sbjct: 1419 VLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKC 1478

Query: 1506 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQ 1565
            + LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA+VTE KQ 
Sbjct: 1479 MKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQD 1538

Query: 1566 LEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQK 1625
            LE+  +L+RKM+KE   L+EWL+AT+ EL ++S  EG+  +LD+E++W K   K++EK+K
Sbjct: 1539 LERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRK 1598

Query: 1626 VHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1685
              L +ITE   AL+ ++   E ++E++L +LN+ W  V +  E+W N L+ +Q  +E FD
Sbjct: 1599 ADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFD 1658

Query: 1686 QNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANR 1745
             NV HI+ W+ QA+ LLDE EKK   ++E+++KRL +EL+D   +V++ RDQA  LM  R
Sbjct: 1659 GNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNAR 1718

Query: 1746 GDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASIPLKELEQF 1786
            G   R+LVEP+++ELN  F  +S  IK+ K                     +P  +LE+ 
Sbjct: 1719 GSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKL 1778

Query: 1787 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1846
             +DI+ +L+ +E       +L+  D ++ M+E++   ++E+LQRG+ +  +  ++ K+E+
Sbjct: 1779 ENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQPMEDNKKEK 1831

Query: 1847 IKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCLDDIEKKLA 1901
            I+++  LL T++N +K +  Q+RK       +  S     Y  + + +L C+DD+E  L 
Sbjct: 1832 IRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL- 1890

Query: 1902 SLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA---AMAVEPTQ 1949
            ++PE            E  +K I  +L K  E++  +  +   +  + +   A+ +  T 
Sbjct: 1891 NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTL 1950

Query: 1950 IQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ 2009
             QL+ +W  I   ++  +      +   R+                    +  ++  ++Q
Sbjct: 1951 TQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FHCDLNDLTQ 1990

Query: 2010 ALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP 2068
             + E E+LL   D CA     DL K     + ++  +         ++      +Q  + 
Sbjct: 1991 WITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQ 2048

Query: 2069 VERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLR 2128
             +   L+E L+ L+ +W+ +    KDRQ R     ++  ++ + +     WLT+AE  ++
Sbjct: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108

Query: 2129 KTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DASILQEKLG 2186
            K    E  E+ +    L++L   +      ++ LN T  E++   S +  +   + E L 
Sbjct: 2109 KRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLR 2165

Query: 2187 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--------NIA 2234
            ++N+ W ++C+++    K   ++ + +S+ +     ++ + VL    +D        +  
Sbjct: 2166 TVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEI 2225

Query: 2235 SIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILKQLNE---- 2272
            SIP +  K            +Q LK  +      E++   V  + + +  L+Q +     
Sbjct: 2226 SIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDY 2285

Query: 2273 --TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2330
              T    L +   S + +  +  KL++   QW      +  +Q ++E  I D  Q +   
Sbjct: 2286 VFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHR 2345

Query: 2331 EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEEILSKGQHL 2389
            E+ EE +            +L I  Q  ++     + + +I +Q   P    +++    L
Sbjct: 2346 EETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVL 2398

Query: 2390 YK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 2444
             K         T+ VK   E L + W  +N L Q +  +Q  L     T+ AS       
Sbjct: 2399 QKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQASRRDLENF 2455

Query: 2445 VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 2504
            + + +   ET ++              L D +     L D  S+L + +K Q      ++
Sbjct: 2456 L-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ------MQ 2493

Query: 2505 DINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE- 2563
            DI   I       + ++  R          Q +     N E  T++  R++ +  +W++ 
Sbjct: 2494 DIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDDMNQRWNDL 2543

Query: 2564 ------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPY--T 2612
                  ++ HL+   ++ N +   L++  +WL  K+E            E  K+ P    
Sbjct: 2544 KAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELKKQMPIGGD 2591

Query: 2613 VDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVHMIT----- 2663
            V A+Q +    K L ++L++ + +V  A D A   L D       +  R +   T     
Sbjct: 2592 VPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPE 2651

Query: 2664 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2723
            E      +++ K+ SE +   E  + +   +   ++K L  L + +   + L DA  KE 
Sbjct: 2652 ERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL-DADMKE- 2709

Query: 2724 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2783
                ++ V+   K   DL         +  +L ++ +KI+   E         + +++++
Sbjct: 2710 ----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLS 2756

Query: 2784 FKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2822
             + S L    SL +   L+  + +WK L +S+ + L  LQ
Sbjct: 2757 SQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796



 Score = 1643 bits (4254), Expect = 0.0
 Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)

Query: 440  EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 497
            E  S +  V MDL + +  L+E+  WL   E+  +  E++ +  D+E++K Q   H+   
Sbjct: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356

Query: 498  EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 555
             +L   Q  V S+      ++   +  D     ++EQ+ +L  RW  +   + DR   L 
Sbjct: 357  MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416

Query: 556  DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 611
            D+L++ Q+   +Q   SAWL+  E+ + K+ T    D    + SLQKL      L++DLE
Sbjct: 417  DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471

Query: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
             ++  +  L  +   ++     +S T   E  L      W  + +  E+   ++ +    
Sbjct: 472  AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530

Query: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
             Q  L               EQ L+K                                  
Sbjct: 531  WQELL--------------EEQCLLK---------------------------------- 542

Query: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
             +W+T  E  L   + + F+ +   S    ++  ++ +   K + L   S   Q  V Q+
Sbjct: 543  -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600

Query: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851
            ++    +  I   SE+L  RW    Q L +  N +      +   +Q+ Q + + T    
Sbjct: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656

Query: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
                                                 R++ Q+I  K K + P       
Sbjct: 657  -------------------------------------RVREQAITKKSKQELPP------ 673

Query: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971
                   +Q+  D++A++K     FD +      E ++ I  W    +T      + + D
Sbjct: 674  -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723

Query: 972  YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 1026
               M+++L   +AL+   +E+      L+ T    V++M K+  P+E   + ++  E++ 
Sbjct: 724  TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777

Query: 1027 GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 1078
              WK +S  L  +E   +L+E +N    +L +++  I+T ++W+    +    ++  P+L
Sbjct: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837

Query: 1079 GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1137
             DS         C+  ++++  + P +         + ++ + P+F  R          +
Sbjct: 838  KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885

Query: 1138 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1189
            +  + + V  R++ L+  L+        +T+   KD+    E   Q     L        
Sbjct: 886  YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939

Query: 1190 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1249
              +++KA++E K   E  + ++  +  L E   ++     P  ++  K+E + +   +  
Sbjct: 940  LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999

Query: 1250 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1309
            L   ++     LEE+        +      KW++ V+  L   +   G    +   LD  
Sbjct: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059

Query: 1310 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1364
                N +   E +   ++ +   L  G V  +   +   L  + ++  +L +E   ++  
Sbjct: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119

Query: 1365 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1419
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177

Query: 1420 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1472
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235

Query: 1473 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1527
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295

Query: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353

Query: 1588 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1643
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413

Query: 1644 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471

Query: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1763
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524

Query: 1764 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1822
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578

Query: 1823 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1882
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636

Query: 1883 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1933
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694

Query: 1934 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1985
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751

Query: 1986 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2043
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811

Query: 2044 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2103
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863

Query: 2104 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2157
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922

Query: 2158 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2217
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982

Query: 2218 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2276
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041

Query: 2277 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2336
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092

Query: 2337 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2393
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150

Query: 2394 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2453
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206

Query: 2454 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2510
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266

Query: 2511 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2570
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326

Query: 2571 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2630
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384

Query: 2631 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2690
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444

Query: 2691 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2750
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504

Query: 2751 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2810
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564

Query: 2811 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2870
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624

Query: 2871 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2927
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684

Query: 2928 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2987
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744

Query: 2988 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 3047
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804

Query: 3048 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 3107
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864

Query: 3108 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3167
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924

Query: 3168 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3227
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984

Query: 3228 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3287
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044

Query: 3288 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3347
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104

Query: 3348 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3407
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164

Query: 3408 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3467
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224

Query: 3468 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3527
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284

Query: 3528 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3587
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343

Query: 3588 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3647
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399

Query: 3648 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3679
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430



 Score =  133 bits (334), Expect = 4e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 1913 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1972
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290

Query: 1973 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 2029
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344

Query: 2030 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2087
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403

Query: 2088 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2145
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461

Query: 2146 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2203
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521

Query: 2204 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2261
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581

Query: 2262 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637

Query: 2319 QIKDLGQLEKKLEDL--------------------------------------------E 2334
             +  LG  +   +DL                                             
Sbjct: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697

Query: 2335 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2390
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756

Query: 2391 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2443
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809

Query: 2444 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2503
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851

Query: 2504 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2563
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888

Query: 2564 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2621
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948

Query: 2622 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2681
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005

Query: 2682 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2740
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061

Query: 2741 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2800
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120

Query: 2801 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2859
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179

Query: 2860 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2919
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238

Query: 2920 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2968
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298

Query: 2969 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 3005
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339



 Score =  102 bits (255), Expect = 5e-21
 Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)

Query: 413  SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 470
            S  E  ++++ +  LN++W+ +     +++    R + + +  +  L +L  W+T+ EE 
Sbjct: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998

Query: 471  TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 530
               ++    G  L+  K ++ Q + L+  +   Q    +L      + +       + L+
Sbjct: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055

Query: 531  EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 590
            E+L  L  RW  I    +DR   L+    +  +   +      WL++ E A+ K  TT  
Sbjct: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113

Query: 591  KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 646
                E+  +LQ+L  L  ++E   +   KL  L +  L  L +KS++     K    L  
Sbjct: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166

Query: 647  FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 706
                W+ + +++  +  +  Q  +    S++QT +         ++ +LV  A +     
Sbjct: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215

Query: 707  PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 766
            P Q  R  T +  I   LD  ITEL  W+   + +L+S    +    G+  ++ + V+ +
Sbjct: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269

Query: 767  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 826
            +  KA+  ++          L + + N+  ++D     +E+L             +  W 
Sbjct: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318

Query: 827  EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 886
              Q+ +     + QQLE M   +  W   +  T       +++L I +      +   P 
Sbjct: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370

Query: 887  IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 932
             +++    I L+E G G    D   +AF N  +++     SD     KE           
Sbjct: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426

Query: 933  --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 976
              Q+I D    +  +  T+ A R        W+Q++ET +++       + ++ D  +  
Sbjct: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486

Query: 977  QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 1035
            +   ++Q +Q+ +         +    ++M K    SE +   Q   +++  RW  L ++
Sbjct: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546

Query: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1095
                   LE    K  ++   ++ L KW+   D  LK++ P  GD   L+ Q   C+ L 
Sbjct: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606

Query: 1096 SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1132
             +++  + S LN+V++       Q I+   EP    + +TEL                  
Sbjct: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666

Query: 1133 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1191
            E+  +W+ +       ++ +   LEK   LQ  + ++   M +AE      +       D
Sbjct: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726

Query: 1192 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1248
             LQ  +E++   +EE      KVK    +VN + +Q  P+       + ++L+ L   ++
Sbjct: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782

Query: 1249 WLCTRLNGKCKTLEE 1263
             L   ++ + K L+E
Sbjct: 2783 LLQVSVDDRLKQLQE 2797



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 2678 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2737
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351

Query: 2738 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2796
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411

Query: 2797 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2854
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469

Query: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509

Query: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 3025
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622

Query: 3026 LLQVAVEDRVRQLHEAHRDFG 3046
             L   +ED   Q+ +A    G
Sbjct: 623  SLVQRLEDSSNQVTQAVAKLG 643



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)

Query: 329  SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388
            S  + L  S    +R   +LEE++ WL   ++ L+ Q  I  DV  ++ Q+   +    +
Sbjct: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608

Query: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 427
            L   +  V N +      +    +   EE                       +++Q + +
Sbjct: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668

Query: 428  NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 482
              +WE L   +   Q  + + L     +KL++L   +   +   ++ E      +P+G  
Sbjct: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723

Query: 483  LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 538
            L D L+  +++    +E++     +   VN L+  +  +D     H +  +  QL  L  
Sbjct: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779

Query: 539  RWANICRWTEDRWVLLQD 556
            RW  +    +DR   LQ+
Sbjct: 2780 RWKLLQVSVDDRLKQLQE 2797



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 2854 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2911
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289

Query: 2912 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2971
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345

Query: 2972 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 3028
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405

Query: 3029 VAVEDRVRQLHE 3040
            V   DR  +LH+
Sbjct: 406  VESMDRQSRLHD 417


>gi|5032297 dystrophin Dp71 isoform [Homo sapiens]
          Length = 617

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 610/610 (100%), Positives = 610/610 (100%)

Query: 3076 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3135
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 3136 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3195
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 3196 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3255
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3256 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3315
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3316 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3375
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3376 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3435
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367

Query: 3436 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3495
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427

Query: 3496 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3555
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487

Query: 3556 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3615
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547

Query: 3616 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 3675
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 548  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 607

Query: 3676 PGKPMREDTM 3685
            PGKPMREDTM
Sbjct: 608  PGKPMREDTM 617



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 376  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 435  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 491  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548


>gi|5032299 dystrophin Dp71b isoform [Homo sapiens]
          Length = 635

 Score = 1214 bits (3142), Expect = 0.0
 Identities = 598/599 (99%), Positives = 598/599 (99%)

Query: 3076 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3135
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 3136 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3195
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 3196 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3255
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3256 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3315
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3316 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3375
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3376 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3435
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367

Query: 3436 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3495
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427

Query: 3496 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3555
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487

Query: 3556 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3615
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547

Query: 3616 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 3674
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 548  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 606



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 376  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 435  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 491  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548


>gi|5032301 dystrophin Dp71a isoform [Homo sapiens]
          Length = 604

 Score = 1203 bits (3112), Expect = 0.0
 Identities = 597/610 (97%), Positives = 597/610 (97%), Gaps = 13/610 (2%)

Query: 3076 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3135
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 3136 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3195
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 3196 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3255
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3256 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3315
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3316 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3375
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3376 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3435
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET             PASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354

Query: 3436 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3495
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414

Query: 3496 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3555
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474

Query: 3556 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3615
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534

Query: 3616 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 3675
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 535  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 594

Query: 3676 PGKPMREDTM 3685
            PGKPMREDTM
Sbjct: 595  PGKPMREDTM 604



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 363  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 422  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 478  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535


>gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]
          Length = 622

 Score = 1177 bits (3046), Expect = 0.0
 Identities = 585/599 (97%), Positives = 585/599 (97%), Gaps = 13/599 (2%)

Query: 3076 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3135
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 3136 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3195
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 3196 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3255
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3256 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3315
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3316 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3375
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3376 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3435
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET             PASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354

Query: 3436 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3495
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414

Query: 3496 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3555
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474

Query: 3556 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3615
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534

Query: 3616 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 3674
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 535  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 593



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2322
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 363  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421

Query: 2323 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2382
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 422  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477

Query: 2383 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2439
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 478  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535


>gi|148539558 dystrophin related protein 2 [Homo sapiens]
          Length = 957

 Score =  996 bits (2574), Expect = 0.0
 Identities = 494/892 (55%), Positives = 651/892 (72%), Gaps = 27/892 (3%)

Query: 2782 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 2841
            MN  W+E++KKS N+R+ LEA SD   +L L LQE++ WL  KD+ELS Q P+ GD   V
Sbjct: 79   MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALV 138

Query: 2842 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2901
            Q++ + H AF  E+K++ P I S LE+ + FL++ P E LE+ + E ++  P++R QN++
Sbjct: 139  QQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLS 198

Query: 2902 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2961
            R + KQA   +  WEKL     D  R I+ TLE+L E+Q A +EL   L QAE ++ +W+
Sbjct: 199  RFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWE 258

Query: 2962 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN 3021
            P+GDL IDSL +H++ +K  + E +P+K+ V  VNDLA QL    + LS  N   LE +N
Sbjct: 259  PIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQIN 318

Query: 3022 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 3081
             RWK LQ +V +R++QL +AHRDFGP SQHFLS+SVQ PWERAISPNKVPYYINH+ QTT
Sbjct: 319  VRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTT 378

Query: 3082 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN 3141
            CWDHPKMTELYQ+LADLNN++FSAYRTAMKLRR+QKAL LDL++L+ A +  ++H+L+ +
Sbjct: 379  CWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQAS 438

Query: 3142 DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT 3201
            +  MD++++I+CLT +Y+RLE+E   LVNVPLCVDM LNWLLNV+D+GR+G++R LSFKT
Sbjct: 439  EHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKT 498

Query: 3202 GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP 3261
            GI  LC   +++K +YLF QVA+S   CDQR LG+LLH++IQ+PRQLGEVA+FGGSN+EP
Sbjct: 499  GIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEP 558

Query: 3262 SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI 3321
            SVRSCF+F+  KP IEA+ FL+W+ LEPQSMVWL VLHRV  AE  KHQ KC+IC++CPI
Sbjct: 559  SVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPI 618

Query: 3322 IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR 3381
             GFRYRSLK FN DICQ+CF +GR +KG+K+HYP++EY TPTTS E++RDFA  LKNKFR
Sbjct: 619  KGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFR 678

Query: 3382 TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA 3441
            +K YF+KHP+ GYLPVQ+VLE D  ET             PASSP   H DTHSRIEH+A
Sbjct: 679  SKHYFSKHPQRGYLPVQSVLEADYSET-------------PASSPMWPHADTHSRIEHFA 725

Query: 3442 SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLS--QPRSPAQILISLE 3499
            SRLAEME+ N S+ NDS+SP++SID++  L++H        SP++  +P    Q   S+ 
Sbjct: 726  SRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRH-------SSPITDREPAFGQQAPCSVA 778

Query: 3500 SEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELI 3559
            +E +GEL++ILA LE+ENR LQ E  RLK QHE    +  PS  +    +    R+ EL+
Sbjct: 779  TESKGELQKILAHLEDENRILQGELRRLKWQHEE--AAEAPSLADGSTEAATDHRNEELL 836

Query: 3560 AEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQ 3619
            AEA++LRQHK RLE RMQILEDHNKQLESQL RLR+LL QP  E+  +G+  SS ++S Q
Sbjct: 837  AEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQ 896

Query: 3620 RSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3671
            +S+ S P   R  G  T D+   +D+ S  QD S  LE++ME+L ++FPS R
Sbjct: 897  QSEGSHP---REKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVR 945



 Score = 65.9 bits (159), Expect = 7e-10
 Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 33/235 (14%)

Query: 2481 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 2540
            E+ DWLS  D+ + +Q  + GD+  + +      A M++++ R P +  ++ +AQ   ++
Sbjct: 113  EIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQ 172

Query: 2541 TSNQE-----ARTIITDRIERIQN--------------QWDEVQEHLQNRRQQLNEMLKD 2581
               +E     + +  T   +RIQN               W+++     ++ + +   L+ 
Sbjct: 173  HPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQ 232

Query: 2582 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
              +   A EE    L QA     +W+  G   +D++ + I   K   ++    +  V + 
Sbjct: 233  LLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLV 292

Query: 2641 NDLALKLLRDYSADDTRKVHMITEN------INASWRSIHKRVSEREAALEETHR 2689
            NDLA +L           VH+  EN      IN  W+ +   VSER   L++ HR
Sbjct: 293  NDLAHQLA-------ISDVHLSMENSQALEQINVRWKQLQASVSERLKQLQDAHR 340



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 51/238 (21%), Positives = 103/238 (43%), Gaps = 30/238 (12%)

Query: 343 RYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 402
           + Q  L+E++ WL   ++ L AQ  +  DV +V+ +  TH  +M ++ +    + ++L+ 
Sbjct: 106 KLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLES 165

Query: 403 GSKLIGTGKLSEDEETE------------------VQEQMNLLNSRWECLRVASMEKQSN 444
               +      E EE                    V +Q  + +  WE L    +++  +
Sbjct: 166 AQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRH 225

Query: 445 LHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLE 501
           + R L  L   +  ++EL+  L++ E    +   EP+G   ++ L   +Q  K+ +E+  
Sbjct: 226 IERTLEQLLEIQGAMEELSTTLSQAE--GVRATWEPIGDLFIDSLPEHIQAIKLFKEEFS 283

Query: 502 --QEQVR-VNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 556
             ++ V+ VN L H + + D     H +    + L+ +  RW  +     +R   LQD
Sbjct: 284 PMKDGVKLVNDLAHQLAISDV----HLSMENSQALEQINVRWKQLQASVSERLKQLQD 337



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 72/339 (21%), Positives = 132/339 (38%), Gaps = 51/339 (15%)

Query: 2187 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQ 2244
            ++NL W E+ K+  + + RLE   +   + Q  L E + WL + D    A +PL+ G   
Sbjct: 78   AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQ-GDVA 136

Query: 2245 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK---------- 2294
             ++++ E     +EE+  R   +  + E+    L   P    E+   E+K          
Sbjct: 137  LVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQN 196

Query: 2295 -----LKQTNLQ---WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL----LL 2342
                  KQ  +    W K++    ++   IE  ++ L +++  +E+L   L+        
Sbjct: 197  LSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRAT 256

Query: 2343 WLSPIRNQLEIYNQPNQEGPFDVQETEIA-----VQAKQPDVEEILSKGQHLYKEKPATQ 2397
            W  PI   L I + P       + + E +     V+       ++     HL  E     
Sbjct: 257  W-EPI-GDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMEN---- 310

Query: 2398 PVKRKLEDLSSEWK----AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2453
               + LE ++  WK    +V+  L++L+    D  PG     +S  Q         V  E
Sbjct: 311  --SQALEQINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQ---------VPWE 359

Query: 2454 TAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQV 2492
             AIS  ++P  +  +       +   TEL   L+ L+ +
Sbjct: 360  RAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNI 398



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 60/257 (23%), Positives = 101/257 (39%), Gaps = 48/257 (18%)

Query: 606 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQI 665
           L+A LE      GKL    Q+++  L  K      +  L         LVQ+ +++ A  
Sbjct: 93  LRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVA----LVQQEKETHAAF 148

Query: 666 SQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKK-------------- 711
            + V +  P +   +V+E+       +  L +H  EEL  P  + K              
Sbjct: 149 MEEVKSRGPYIY--SVLESA------QAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRF 200

Query: 712 --RQITVDSEIRKRLDVDITELHSWITRS-------EAVLQSPEFAIFRKEGN------- 755
             +Q TV SE+ ++L     + H  I R+       +  ++     + + EG        
Sbjct: 201 VWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPI 260

Query: 756 ----FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD-SIKQASEQLNS 810
                  L E + AI+  K E+F  ++D  +    L  Q+    V+      QA EQ+N 
Sbjct: 261 GDLFIDSLPEHIQAIKLFK-EEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQINV 319

Query: 811 RWIEFCQLLSERLNWLE 827
           RW +    +SERL  L+
Sbjct: 320 RWKQLQASVSERLKQLQ 336



 Score = 41.6 bits (96), Expect = 0.015
 Identities = 43/256 (16%), Positives = 106/256 (41%), Gaps = 22/256 (8%)

Query: 1029 WKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQL 1088
            W ++  +      +LE   +   K+Q  +Q +  W+++ D  L  + P  GD  +++++ 
Sbjct: 83   WNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEK 142

Query: 1089 KQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQ----------- 1137
            +     + ++++  P + SV E  Q   ++   E      +E K+ + +           
Sbjct: 143  ETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVW 202

Query: 1138 ---------WDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE-EEYLERDFEY 1187
                     W+ +  +   +   ++  LE+ + +Q  + E+   ++QAE           
Sbjct: 203  KQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPIGD 262

Query: 1188 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY 1247
               D L + ++ +K  KEE    +  VKL+ +  + +      ++ E   + LE +   +
Sbjct: 263  LFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMEN-SQALEQINVRW 321

Query: 1248 QWLCTRLNGKCKTLEE 1263
            + L   ++ + K L++
Sbjct: 322  KQLQASVSERLKQLQD 337



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 35/174 (20%), Positives = 77/174 (44%), Gaps = 14/174 (8%)

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
            A+ L +NE+  K    + +LE     S K++  +  + +WL+  D EL+ +  ++G  + 
Sbjct: 78   AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVAL 137

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEAL----------KTVLGKKETLVEDKL-SL 1655
            +  E     A  +E++ +  ++ S+ E  +A           +     K+T  + ++ +L
Sbjct: 138  VQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNL 197

Query: 1656 LNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1706
                W   T  +E W  L    ++  +H+E   + +  I   + +  T L ++E
Sbjct: 198  SRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAE 251



 Score = 35.4 bits (80), Expect = 1.1
 Identities = 54/267 (20%), Positives = 108/267 (40%), Gaps = 39/267 (14%)

Query: 1134 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1193
            +N  W+ + ++ +  +  L+   + +  LQ  L E+ +W++Q +EE L      +    L
Sbjct: 79   MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEE-LSAQLPLQGDVAL 137

Query: 1194 QKAVEEMKRA-KEEAQQKEAKVKLLTESVNSVIAQAP--------PVAQEALKKELETLT 1244
             +  +E   A  EE + +   +  + ES  + ++Q P          +++   K+     
Sbjct: 138  VQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNL 197

Query: 1245 TNYQW--------LCTRLNGKC--------KTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
            + + W        L  +L  +C        +TLE++     E+   +E+ +  L++ E  
Sbjct: 198  SRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLL----EIQGAMEELSTTLSQAEGV 253

Query: 1289 LKTTENIPGGAEEISEVLDSLENLMRHSE------DNPNQIRILAQTLTDGGVMDELINE 1342
              T E  P G   I  + + ++ +    E      D    +  LA  L    V   + N 
Sbjct: 254  RATWE--PIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENS 311

Query: 1343 E-LETFNSRWRELHEEAVRRQKLLEQS 1368
            + LE  N RW++L      R K L+ +
Sbjct: 312  QALEQINVRWKQLQASVSERLKQLQDA 338



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 33/163 (20%), Positives = 73/163 (44%), Gaps = 21/163 (12%)

Query: 2057 SKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIF 2116
            SK T+  Q    + R   ++A    +  WEK+     D+    +R++E+       ++  
Sbjct: 185  SKDTSPKQRIQNLSRFVWKQATVASEL-WEKLTARCVDQHRHIERTLEQLLEIQGAMEEL 243

Query: 2117 NQWLTEAEQFLRKT----------QIPENWEHAK-YKWYLKELQDGIGQRQTVVRTLNAT 2165
            +  L++AE  +R T           +PE+ +  K +K     ++DG+     +   L  +
Sbjct: 244  STTLSQAEG-VRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAIS 302

Query: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 2208
               +  ++S+         L  +N+RW+++   +S+R K+L++
Sbjct: 303  DVHLSMENSQA--------LEQINVRWKQLQASVSERLKQLQD 337


>gi|5032305 dystrophin Dp40 isoform [Homo sapiens]
          Length = 340

 Score =  693 bits (1789), Expect = 0.0
 Identities = 333/333 (100%), Positives = 333/333 (100%)

Query: 3076 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3135
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 3136 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3195
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 3196 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3255
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 3256 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3315
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 3316 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3375
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 3376 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 3408
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 340


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  370 bits (950), Expect = e-101
 Identities = 574/2872 (19%), Positives = 1190/2872 (41%), Gaps = 335/2872 (11%)

Query: 328  KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
            ++F   L E+E ++   +T+     LE+ +  L S  D   ++G +   VE +  +  + 
Sbjct: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828

Query: 383  EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 438
            E  +M++TA   QG+ G+IL      +G+  G  +  + TE+Q  M+ +N ++E L    
Sbjct: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888

Query: 439  MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 496
             E+Q +L  +L  M+  +++   +  WL   EE  + M+        E +K Q + +K  
Sbjct: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948

Query: 497  QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 556
              +LEQ   ++        V +  +G   T    ++     + W  I      RW    +
Sbjct: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998

Query: 557  ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 605
            + +  QR  EE      C  +A      WL EKE  +  +      D N + +  Q++  
Sbjct: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057

Query: 606  LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 664
            +  + E ++Q   +L    Q +L+   + S+ T + +  L +  + W  L  KL   ++Q
Sbjct: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117

Query: 665  ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIR-- 721
            I QA+  +TQ       + E V  V  R  +     Q  +   P   K+Q+   SEIR  
Sbjct: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRSD 3172

Query: 722  -KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA 780
             ++LD ++ E  + +    +VL   ++     +     +   +  +E   A++  +LQ A
Sbjct: 3173 LEQLDHEVKEAQT-LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAA 3231

Query: 781  SRSAQALVEQMVNEGVNADSIKQAS-----------EQLNSRWIE---FCQLLSERLNWL 826
              S Q   +QM +E       KQ+            E+L S+  E   F + L++     
Sbjct: 3232 LASTQQF-QQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290

Query: 827  EY---------------------QNNIIAFYNQLQQLEQMTTTAENWLK----------- 854
            E                      QN ++   N  ++L + T   ++ LK           
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350

Query: 855  -IQPTTP--SEPTAIKSQLKICKDEVNRLSGL---QPQIERLKIQSIALKEKGQGPMFL- 907
             ++   P   +  A  S+L++  D V   S L   +  +  ++ +   L+        L 
Sbjct: 3351 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 3410

Query: 908  ---DADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-----RYQETMSAIRTWVQQSE 959
               +AD     +    +  ++ A  +ELQ    +L  M      +QE+   I   V+ ++
Sbjct: 3411 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP--SEISRK 1017
             +L I   ++       + L +L+A Q  LQ  +  + YL    + + + AP  S+ S+ 
Sbjct: 3471 HQLEIFD-ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3529

Query: 1018 -YQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
             +Q+E  + E  + ++  ++   C  +E ++  + +    ++ +   +A++D  L     
Sbjct: 3530 LHQAEVAQQE--FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA 3587

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1136
               D++ L+ Q++  RL ++ I  ++  + +     + +  E        L+ EL+ LN 
Sbjct: 3588 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3647

Query: 1137 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPDELQK 1195
            Q   + ++  AR+E L+  L +     + L  +++  T AEE E L+     +     Q+
Sbjct: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3707

Query: 1196 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ-EALKKELETLTTNYQWLCTRL 1254
              +     KE+    + K++ +      +I  A      + L+ ++E +   +  L  ++
Sbjct: 3708 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3767

Query: 1255 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1314
              +   L+E      +    LE    WL + E  +   +      + +   +   + L R
Sbjct: 3768 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQR 3827

Query: 1315 HSEDNPNQIRILAQTLTDGGVMD--------ELINEELETFNSRWRELHEEAVRRQKLLE 1366
              +D    + +L     +GG +         E I  +LE+  SRW EL  +A  RQK LE
Sbjct: 3828 LLDDRKATVDMLQ---AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884

Query: 1367 QSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA---QKIQSDLTSHEIS 1423
              +  A++  ++   I + L+  +K+LA         A++ Q+    + ++ D+ +H   
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944

Query: 1424 LEEMKKHNQG-----KEAAQRVLSQ-IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477
            + +  K  Q        A Q VLS+ ID  Q +  ++  + R  +K A  +Q L  +++ 
Sbjct: 3945 VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI--QDRCCRKAALLDQALSNARLF 4002

Query: 1478 ----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
                      L EV+  L ++  K  +Q+V+  Q    + L + +   K  V+  IK G+
Sbjct: 4003 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062

Query: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
             ++++   E    + E++  +K  Y ++    ++  + LE+  +L+ K +     LT WL
Sbjct: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122

Query: 1588 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ----KVHLKSITEVGEALKTVLG 1643
               + EL    A  G  S    ++   +  QKE++K+    ++ L ++ EV  AL  ++ 
Sbjct: 4123 REVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178

Query: 1644 KKETLVEDKL-SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1702
             +     DKL S  N  +  V+    + ++ +    +  + ++Q  D    W+ +    L
Sbjct: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238

Query: 1703 D-----ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 1757
                    E+ +   +  V K    ++   +  +D      + +    G+  + +++ + 
Sbjct: 4239 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 4298

Query: 1758 SELNHRFAAIS-----HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ--GVNLKEE 1810
              L  ++ AIS        +  +A + + +  +   ++   +E   A I Q     +  E
Sbjct: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358

Query: 1811 DFNKDMNE---------DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1861
               +   E         +++  + +LL+ G  L+     E   EE ++ ++  Q   N  
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK-----ELNPEEGEMVEEKYQKAENMY 4413

Query: 1862 KDLRSQRRKKALEI------SHQWYQYKRQADDLLKCLDDIEKKLASLPE-PRDERKIKE 1914
              ++ + R++AL +      S Q  ++  + + +L+ L+++  +L   P  P +  KI+E
Sbjct: 4414 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473

Query: 1915 IDR-------ELQKKKEELNAVRRQAE-------GLSEDGAAMAVEPTQIQLSKRWREIE 1960
                      EL+K +    A++R+ E       G  +D AA  ++    Q+   W +I+
Sbjct: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533

Query: 1961 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA 2020
            ++ A+ R + F  +  + E+              Y  +  LT I      + ++E     
Sbjct: 4534 AR-AEEREIKFLDVLELAEKFW------------YDMAALLTTIKDTQDIVHDLESPGID 4580

Query: 2021 PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQ 2080
            P +       + +Q E+ + IK+        ++ I       + +    E+ ++++++ +
Sbjct: 4581 PSI-------IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDE 4633

Query: 2081 LDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAK 2140
            ++  WE +NK +K+R  + + +++   ++   ++    WL      L  T  P   +   
Sbjct: 4634 MNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC-TMPPVGTDLNT 4692

Query: 2141 YKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSS-KTDASILQEKLGSLNLRWQEVC 2196
             K  L E+++    + Q+Q  +  LN  GE ++++++ +TD  I++E L  L   W+ + 
Sbjct: 4693 VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4752

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQLKEKLEQVK 2254
            ++++ R+ +LE     L +FQ  L E + WL   + +  A  P+  G  + ++ +L +  
Sbjct: 4753 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHH 4811

Query: 2255 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ- 2313
            +L  ++   Q  ++ +N+ G  +L S+  + ++   L ++L+  N  W  V +   E++ 
Sbjct: 4812 VLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4869

Query: 2314 -------------GEIEAQIKDLGQLEKKL----------EDLEEQLNHLLLWLSPIRNQ 2350
                          EIE  + +L ++E +L          E   EQL+  +   S ++ +
Sbjct: 4870 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4929

Query: 2351 LEIYNQPNQEGPFDV-QETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED---L 2406
             E YNQ   +G   +    +    +K      +L +  H+   K   +  K KLE+   L
Sbjct: 4930 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER--KSKLEEALNL 4987

Query: 2407 SSEWK-------------------------AVNRLLQELRAKQP---------DLAPGLT 2432
            ++E++                          +N +L ++   +          D    L 
Sbjct: 4988 ATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 5047

Query: 2433 TIG-----ASPTQTVTLVTQPVVTKETAISK-----LEMPSSLMLEVPALADFNRAWTEL 2482
              G      S  Q V L+   +V+ ++   K     +E   SL         F+ AW +L
Sbjct: 5048 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 5107

Query: 2483 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2542
             DWL   +  + S+  +  D + I   + K K   + L  ++P  +  I   + LK KT 
Sbjct: 5108 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 5167

Query: 2543 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2602
              E    + + +  ++++WD V      R+ +L E L  S Q+++A +     L +   +
Sbjct: 5168 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 5227

Query: 2603 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
            L   +     +D +   +   K   K+L +    V V      +L+ + S DDT  V   
Sbjct: 5228 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQ 5286

Query: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDAT 2719
             + ++  W ++ K    +++ LE+  +  + F   +   L WL+EAE T      L D T
Sbjct: 5287 LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT 5346

Query: 2720 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 2779
               + L D+   KE MK+ ++ + ++ +   +         +++ ++   D    ++  +
Sbjct: 5347 EALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPDCITTIKHWI 5396

Query: 2780 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGD 2837
              +  ++ E+   +   +  LE +  +       L+ELL W+Q  +  L +  Q PI  +
Sbjct: 5397 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQN 5456

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEGLEKLYQEPR 2889
               V+     H+ F  E+  K+P +           +E       E+   G  K   +P 
Sbjct: 5457 IDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP- 5515

Query: 2890 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              PP     + +     +  +++  W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 5516 -TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566



 Score =  351 bits (900), Expect = 9e-96
 Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)

Query: 384  GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 443
            G+ +DL  HQ RV N+ +  ++L  T K  E + +  QEQ++         +    E + 
Sbjct: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783

Query: 444  NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
            ++      +  ++L++        L+DW +K    T   E    G  LE+L        +
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832

Query: 496  LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 551
            ++      Q +  S+   V   V   +G H    L E    + D   ++  +     +R 
Sbjct: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892

Query: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
              LQ IL + + + +E      WL  KE+ +  +       + E + +  +    KA L 
Sbjct: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950

Query: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
            + +Q+  K+  +K+ L   L     +Q+ E W                    +I + + +
Sbjct: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991

Query: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
                 T+ TV                            ++RQ+   +          ++L
Sbjct: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024

Query: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
              W+   E ++      +       +  K++V  + +E   + ++ +  + +AQ ++   
Sbjct: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083

Query: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 850
             +  ++   +++  + +N +W+E    L+ R + ++        Y +L Q L +      
Sbjct: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143

Query: 851  NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 889
              L +Q    ++P A+K QL+                     +C DE++ L G Q   + 
Sbjct: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202

Query: 890  LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 947
            LK  ++++AL  +G   +  D       N  +   +  Q                ++Q+ 
Sbjct: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241

Query: 948  MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1005
               +RTW+   +++ +         E ++ +L E +  Q SL  Q SG Y +     E  
Sbjct: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300

Query: 1006 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1065
            +    P E  R  Q++  E++  W++LS +  +   +L++ M K +K Q H++ L  W+ 
Sbjct: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360

Query: 1066 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1125
            +    + E    L D   L+  L + + ++++++  +  L  +N     + N +E +   
Sbjct: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418

Query: 1126 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1185
             +  E   +N   D + +++ A+  +L+   ++    Q+    + + +  A+ + LE   
Sbjct: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477

Query: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1244
               +     K +E+++  +E  Q  E +V  L      ++  AP  +  + L  + E   
Sbjct: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537

Query: 1245 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1297
              +  +  R+N  C  +E   E    +H    E+ S L   +  L+ +    + T+++  
Sbjct: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597

Query: 1298 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1356
              E++   L+ +  L    E +  + R +   L + G +D L +  ELE  N +  +L E
Sbjct: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654

Query: 1357 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1396
                RQ+ LE ++                  +A+E E    ++   +  I++QLA    +
Sbjct: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714

Query: 1397 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1443
              ++VD  QM  +         IQS     D+   E  +EE+    +   K+ AQR+   
Sbjct: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
                  +LQ+  +          F+  L+     L + +  +   +  S E +VV++Q+ 
Sbjct: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820

Query: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563
                L + L + K+ V+M+   G +I Q  +  + +++  ++ +L+  + EL +K   R+
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880

Query: 1564 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623
            +QLE  L L+++  +    ++++L+ T+ +L     V    + +  ++   KA +++IE 
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940

Query: 1624 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1682
                +    ++G++L ++    E  ++ +K+  L + +  +  R      LL +   +  
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000

Query: 1683 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1735
             F ++   +  W+ + +  L     K    K+DVL R       L  E+ + +  VD   
Sbjct: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058

Query: 1736 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                 L+         L++ ++  +  R+A I+  + + KA   L++  Q  +  Q   E
Sbjct: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
             L   +++   ++EE             + +  QR   L++ + + R      +    + 
Sbjct: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167

Query: 1856 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1913
                AL +L   R ++ L+  +S    QYK  +D + + +D+I+  +      R ++  +
Sbjct: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222

Query: 1914 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1965
              D EL      ++K   L  +R + +   +  A + V+    I + +    ++  F+  
Sbjct: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279

Query: 1966 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2010
               F      Q   ++E+T  ++ +   + +              + + +      +S  
Sbjct: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339

Query: 2011 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2070
            + E   L+      A D E L +Q+E ++ +++S+ +    ID +  K    L+   P E
Sbjct: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398

Query: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2127
               ++E   + +  + ++ +  + R    D +V +  +   FH  I+   + L      L
Sbjct: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458

Query: 2128 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2180
            R    IP   E  K +  + + +     + + Q     L   GEE+I +S   D  +   
Sbjct: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516

Query: 2181 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2239
             +Q+KL  +   W+++  +  +R+ +  +   +  +F  D+   +  +++  +I      
Sbjct: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576

Query: 2240 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
            PG +  + K+++E  + + EE       L+ +   G  ++ +      E+ ++   + + 
Sbjct: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634

Query: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2355
            N  W  +++   E+  ++E  ++   Q +  L+ + + L++ ++ L    P+   L    
Sbjct: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694

Query: 2356 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2415
                E    ++E ++ V  +Q ++E++  +G+ + K+  AT    R +         +  
Sbjct: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739

Query: 2416 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2475
             L EL+    +L                        ++ A  + ++  +L+    AL  F
Sbjct: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772

Query: 2476 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2535
              A  EL  WL+  ++++ +QR + GD + I   + K      D+   +  +E +  A  
Sbjct: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832

Query: 2536 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2595
             L   ++  +A + +  R+E +   W+ V +  + R QQL   L+ +  +    E+    
Sbjct: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891

Query: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2654
            L +  ++L + K      +  ++++    +L   L+ + +T   + +   L LL    + 
Sbjct: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951

Query: 2655 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2714
               K       +   W  +  ++ ER++ LEE   L  +F   L++F+ WLT AE + N+
Sbjct: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011

Query: 2715 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2774
               A+    +L     V   +++ +    E+ AH D    LD+   + L+ L    D VL
Sbjct: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064

Query: 2775 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2834
            ++  L ++  +W ++ ++S+     L+ +  + K+ H + ++L+ WL+  +  L  +  I
Sbjct: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124

Query: 2835 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2894
              D   ++ Q   H+ F++ L  K+PV  +T+ T R                + + L PE
Sbjct: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2954
            + +Q +   L     EV  +W+ +   S + Q K++E L    +  +A   L   L + E
Sbjct: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225

Query: 2955 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3013
                  QPV GDL  D + + ++  K  + E+      V  +    R+L       + + 
Sbjct: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283

Query: 3014 LSTLEDLNTRWKL---LQVAVEDRVRQ 3037
               L++L+TRW     L V+ + R+ Q
Sbjct: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310



 Score =  296 bits (757), Expect = 3e-79
 Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)

Query: 343  RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            ++Q + + + +W+ + E  ++      +++D  V+++Q  T +    +L  HQ  V  + 
Sbjct: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497

Query: 401  QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 458
            ++   ++        +   VQE  + + S ++ L  +  E+ S L + +   Q+  + L+
Sbjct: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557

Query: 459  ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 518
             L   + + E+     +   L   +  ++  +  +  L++D+ +++  + +   MV    
Sbjct: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615

Query: 519  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 578
            E++     A L+ +L  +  R+  +C   +++   L+ +L + +         S  L + 
Sbjct: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671

Query: 579  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 638
             +  +++  +G +   ++    Q++  L  ++E +++++  L  L  +L S      + Q
Sbjct: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731

Query: 639  KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 696
              +             VQ L K   ++ + V   +   S  Q  + E    V T ++ L 
Sbjct: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778

Query: 697  KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
            K  +  +PP       +     E+ K+++   + L  W ++   V +     I  K  + 
Sbjct: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828

Query: 757  SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 810
             +L  ++ A +          Q  + S    V   V       + K  +E       +N 
Sbjct: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 861
            ++ +   +L ER      Q ++ A  N+++++ +   +   WL+ +          ++P+
Sbjct: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 915
            +   +K+Q +  K  +  L    P+I+++K     L       ++ +    +  +     
Sbjct: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            + +++      AR+++L+     L    +Q   S +R W+ + E  + +      D  ++
Sbjct: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1032
              +  ++Q +    + ++     L+   + +    P ++S    + Q E + I  +W +L
Sbjct: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107

Query: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
            + +L     ++++ + K  + Q  +Q L + +  V   L  +       E +K+QL++  
Sbjct: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167

Query: 1093 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1143
             + SD++ +   +          SV  G Q +K+E +     RLET    L    D    
Sbjct: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223

Query: 1144 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1203
            ++      L+  L  T   Q+   E+  W+   + +  +        + LQ  ++E +  
Sbjct: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279

Query: 1204 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1262
            ++   Q     +++     S++   PP  ++  L+ +L  L  +++ L  +   +   L+
Sbjct: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339

Query: 1263 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1322
            +      +   ++E    W+ + + K+          +  S +L S + ++   E   + 
Sbjct: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398

Query: 1323 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
            + IL   A  L +    DE  I +E    N     + EE   +   LE+  Q  +E ++S
Sbjct: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458

Query: 1379 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1434
               I++ +     QL  +  +  +  + +  ++ +  Q  L + E  ++ ++   QG   
Sbjct: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518

Query: 1435 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1481
                   A ++L Q +VAQ++  +V  +            +    F  R++E    L ++
Sbjct: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578

Query: 1482 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1541
               L  +     + + +QSQ+         +  +K ++E      R +++++ T +   L
Sbjct: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638

Query: 1542 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1601
               + AL     +L  +   R++QLE  L       +++  L +   A +     +  V 
Sbjct: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698

Query: 1602 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1658
                 ++ ++A  K  QKE ++  ++ L+ +  +G+ L    GK   +  +E  +  +N+
Sbjct: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1718
             W  +  +  + +  L E   H   F   ++ +  W+   + L+  + +K P  +  V+K
Sbjct: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816

Query: 1719 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1771
                    L+  L+D +  VD  + +   +  +     R+ +  Q+  L  R+  +    
Sbjct: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872

Query: 1772 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1808
               KA+   K+LE                  F S  +K L   EP+    A+IQQ + ++
Sbjct: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930

Query: 1809 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1868
             +   +D+ E++   V + ++ G +L   +T   ++  +  K   LQ +++ ++D   ++
Sbjct: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988

Query: 1869 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1923
                 +       +     ++L  L ++E KL+S+        +K+  +++  ++     
Sbjct: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041

Query: 1924 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
               EE+   ++  +   ++G A+  + T  ++     +++       +  +A I     +
Sbjct: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096

Query: 1981 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2040
             +  + +   L   +  STY      ++  L EVE+ L      +   E + + ++  K 
Sbjct: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151

Query: 2041 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
            +K  + +    +D ++    A L+      R  L + +S  + Q++ V+     R    D
Sbjct: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211

Query: 2101 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2157
             ++++ +++         W+ E ++ L      ++ ++   A+ +   K     I + + 
Sbjct: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270

Query: 2158 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2217
             +  L +   EI     +   ++LQEK  SL  +++ +    S+R  RLE  + ++++F 
Sbjct: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330

Query: 2218 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2276
                E   W+EE    IA +P      +QL+++ E+++ L E +   +  + +L + G  
Sbjct: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390

Query: 2277 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2333
            +     ++PEE + +E K ++    + ++   + ++     E  +Q   + +   K+E +
Sbjct: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447

Query: 2334 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2387
             E L +L   L + P+     +++      N+    ++++ + + +A +   EE++ + Q
Sbjct: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507

Query: 2388 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2435
               K+  A + ++ KL+ +   W+ +    +E   K             D+A  LTTI  
Sbjct: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566

Query: 2436 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2460
                     SP    +++ Q V   ET                              K E
Sbjct: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626

Query: 2461 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2499
            +  S+     A  + N+ W E                     + DWL      + +   +
Sbjct: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686

Query: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
              DL  + + + + K    ++ Q++ ++E+L    + +  K +++  R II + +  +++
Sbjct: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746

Query: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
             W+ + E + +R+ +L   L    Q+  A EE    L      L++ +        I+ +
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806

Query: 2620 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2679
            + +   L  D+   Q  V+  N    +LL   + DD   +    E +N  W S+ ++  E
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866

Query: 2680 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2739
            RE  L+ T +  Q F  ++E FL  LT  E+  +    A++    L ++   +E +    
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920

Query: 2740 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2799
            +L  +++A  + Y+ L +  + +L S + S      ++ +  +  KW  +  K    +S 
Sbjct: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980

Query: 2800 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2859
            LE + +       SLQE + WL L +  L+  +P       V  Q + H+ F  E+    
Sbjct: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040

Query: 2860 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2919
              I+                   +L Q   +L    + Q+V  L++     V + WEK+ 
Sbjct: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080

Query: 2920 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2976
              S +  R +D+  +R ++  EA  +L   L  AE    S   +    D +   L  H E
Sbjct: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140

Query: 2977 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3036
              K L G+  P+ +         ++ T L       + + L ++  +W  +     +R  
Sbjct: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198

Query: 3037 QLHEA 3041
            +L EA
Sbjct: 5199 KLEEA 5203



 Score =  259 bits (663), Expect = 3e-68
 Identities = 534/2921 (18%), Positives = 1135/2921 (38%), Gaps = 320/2921 (10%)

Query: 328  KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 377
            + + +SL +SE  L + QT  +E+           SWL  +E  L+   +  +  E +  
Sbjct: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355

Query: 378  QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 431
                   +  D+ +H+G +  +   G K++        GK   +    V++++     R+
Sbjct: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415

Query: 432  ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 489
              L        S+L+ +L            L  W+   E    K+  + +  D   L+ Q
Sbjct: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475

Query: 490  VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 549
            +   K LQE+L + QV V  L  +   + E  G+ A      Q                 
Sbjct: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518

Query: 550  RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 609
                   IL  +Q L       S  L+E+   + K        Q  + S LQ +  ++ +
Sbjct: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569

Query: 610  LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 669
            LE K+ S      +++ L + +K K    + ++ L+         ++  + +TA + Q  
Sbjct: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629

Query: 670  TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 724
                    +   ++     ++ +++L      +H   +L      K R +   ++     
Sbjct: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685

Query: 725  DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 784
            D DIT     I      ++  +  +   E   ++L     A+  +  +   ++Q+  +  
Sbjct: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743

Query: 785  QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 844
              L + +     +A S ++  ++       F + L E    +      ++     +Q+E 
Sbjct: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803

Query: 845  MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 898
            + +  ++W   + T   E     + L+         D   +   + P +    + S+   
Sbjct: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861

Query: 899  EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 958
               +    +  D       ++++   +  R++ LQ I + +  + ++E  S ++ W++  
Sbjct: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919

Query: 959  ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
            E  L       S T  E ++ +    +A  + L++    +  +   +  +    P S+ +
Sbjct: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
              ++   EE+  RW++ +   V   ++LEE  + L   Q     L+ W+ E ++ +    
Sbjct: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1133
            P   D  +L  Q +Q + ++ + +  +     +NE  Q I           S+++ EL+ 
Sbjct: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099

Query: 1134 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1193
            +N +W  +  ++ +R   +   + K+   Q+ L ++ E +    +    +      P+ +
Sbjct: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159

Query: 1194 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1250
            ++ +EE    + + +Q + +VK    L + ++ +I +     ++ LKK LET+    Q L
Sbjct: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217

Query: 1251 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1310
                  +   L+   A   +     ++   WL++ + +      I    E +   L   E
Sbjct: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277

Query: 1311 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1364
               +    +     ++             G     +  +L    + W EL ++   RQ  
Sbjct: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337

Query: 1365 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 1424
            L+  +Q AQ+ +     +++ + +I+   A     K+   ++  +  +++S L   +  L
Sbjct: 3338 LKDCMQKAQKYQWH---VEDLVPWIEDCKA-----KMSELRVTLDPVQLESSLLRSKAML 3389

Query: 1425 EEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 1480
             E++K     E    AA  +++  +  +  ++D   K  + Q      + LQ     L+E
Sbjct: 3390 NEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGSLEE 3447

Query: 1481 VKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEMVIK 1524
            +   L   +   K++E++V               Q+  N  +   ++  EV   +E  + 
Sbjct: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507

Query: 1525 TGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK---- 1578
              R   Q    + P   D    +  LH  E+   +  E KQ++   C+ +  K+      
Sbjct: 3508 YLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564

Query: 1579 --EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSITEVG 1635
               +  +   LA  D EL    A+     +L S++         +   K+H LK   E  
Sbjct: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDIEAS 3619

Query: 1636 EA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQN 1687
            EA  + +L ++ TL    ++ +L  LN     +T R    +E L L L     +E F + 
Sbjct: 3620 EAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDFYRK 3676

Query: 1688 VDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDSTRDQ 1737
            +    K +  A T  +E+E  +           QQ  D     K +++ ++ K+      
Sbjct: 3677 L----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGL 3732

Query: 1738 AANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLKELE 1784
               L+ + G  C  + +E  + E+N R+  ++ ++              GK    L+ L 
Sbjct: 3733 GQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLL 3792

Query: 1785 QFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 1840
             + +D ++L+   +P  AE +     ++E+   + + +D + TV  L   G  + Q   +
Sbjct: 3793 SWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-AE 3851

Query: 1841 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 1900
               RE+I  + + L+++   L    + R+K+  +I     Q+   A+ +   L   EKKL
Sbjct: 3852 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3911

Query: 1901 A-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
            A S P      KI++     + L++  E       QA  + +  +++     Q  LS++ 
Sbjct: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3971

Query: 1957 REIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQ 2016
              +++++++       Q    R+  ++    D  L  + +   +  +   V   L EVE 
Sbjct: 3972 DSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAEVED 4018

Query: 2017 LLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2074
             L++  +  KDF+   L +Q      + + +      +D       A L+  T  E + +
Sbjct: 4019 KLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI 4076

Query: 2075 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT--QI 2132
            QE L  +  ++  +           +++ +   +F    +    WL E E+ L  +  Q 
Sbjct: 4077 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQS 4136

Query: 2133 PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2192
            P   +  +++   KEL+  + + + V+ T+N     +++         L + +   N ++
Sbjct: 4137 PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196

Query: 2193 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKL 2250
            + V   +  R   ++       ++++  +  + W+ E     +A  P+   ++Q   +  
Sbjct: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ 4256

Query: 2251 EQVKLLV----------EELPLRQGILKQLNETGGPVL---VSAPISPEEQDKLENKLKQ 2297
             Q    +          E    R  I     E    VL     + I   E   L N  + 
Sbjct: 4257 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 4316

Query: 2298 TNLQ------------------WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQL-- 2337
              L+                  WI+ +RAL  +        + L Q ++++  L E +  
Sbjct: 4317 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 4376

Query: 2338 --NHL--LLWLSPIRNQL-----EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQH 2388
               H+  LL + P   +L     E+  +  Q+      + +  V+ +   ++E +S+   
Sbjct: 4377 HKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ 4436

Query: 2389 LYKEKPATQPVKRKLEDLSSEWK-------AVNRLLQ----------ELRAKQPDLAP-- 2429
            + +     +P+   LE+LSS  +        V+++ +          EL   QP      
Sbjct: 4437 ITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALK 4496

Query: 2430 --GLTTIGASPTQTVTLVTQPVVTK--------ETAISKLEMPSSLMLEVPALADFNRAW 2479
              G   IG S      L  + +  K        E   ++ E      L+V  LA+  + W
Sbjct: 4497 RRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAE--KFW 4554

Query: 2480 TELTDWLSLLDQVIKSQRVMVGDLED--INEMIIKQKA-TMQDLEQRRPQLEELITAAQN 2536
             ++   L+     IK  + +V DLE   I+  IIKQ+    + +++    L E +   + 
Sbjct: 4555 YDMAALLT----TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRI 4610

Query: 2537 LKNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2593
            L         +  +  +   I+ + N W+ + +  + R ++L + ++ + Q+ +  +   
Sbjct: 4611 LGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMF 4670

Query: 2594 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2653
              L     KL +       ++ ++ ++ E K+   ++ Q Q  ++  N     +L+  + 
Sbjct: 4671 DWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATD 4730

Query: 2654 DDTRKV--HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
            +  R +    +TE +   W ++ ++++ R+  LE     L QF   LE+ ++WLT  E  
Sbjct: 4731 ETDRDIIREPLTE-LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE- 4788

Query: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
               L DA R   +  D K ++  + +   L+ ++ AH      +++   ++L S  G DD
Sbjct: 4789 ---LLDAQRP--ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DD 4842

Query: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
            A  L+ RL+ MN  W  + +K+      L+++  Q +  H  +++ L+ L   + +LS  
Sbjct: 4843 ASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSAS 4902

Query: 2832 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2891
             P GG     ++Q D H     +LK KE      L+  R+ L  +   G           
Sbjct: 4903 KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG----------- 4951

Query: 2892 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2951
               +  Q+V  L +K        W  ++    + + K++E L    E Q +  E    L 
Sbjct: 4952 SGSKTEQSVALLEQK--------WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLT 5003

Query: 2952 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3011
             AE       P   L+++++   +E+ K    E+   ++ +  ++    QL  L  +   
Sbjct: 5004 LAEQSLNIASP-PSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDV 5062

Query: 3012 YNL-STLEDLNTRW-KLLQVAVE---------DRVRQLHEA 3041
              + + L  + +RW K++Q ++E          R +Q HEA
Sbjct: 5063 VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103



 Score =  233 bits (594), Expect = 3e-60
 Identities = 536/2936 (18%), Positives = 1125/2936 (38%), Gaps = 426/2936 (14%)

Query: 337  SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 394
            SE+++D     L++        ED  Q   E    ++ +    QF   E +  DL+  Q 
Sbjct: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003

Query: 395  RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 453
            R   +L+L ++L  + + + E    +V      L    +   V +++KQ N         
Sbjct: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054

Query: 454  NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
            +Q+L++L  W+ + E      +      DL  L++     K LQ+D++      N  T  
Sbjct: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108

Query: 514  VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 573
              VV +  G      +EE    L  R     R        L     +++ L EE  +   
Sbjct: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157

Query: 574  WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 630
             L E   +  +  T   K   E+  + +K+  L   +     S G+L +     + L   
Sbjct: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217

Query: 631  LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 686
               K     T+ ++    +  + L ++ E   A+  + ++  Q  +  T   +       
Sbjct: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276

Query: 687  -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 737
              +T  EQ +++    E        L     + K+  T+  E++K L  D  E  SW+ R
Sbjct: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335

Query: 738  SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 788
            SE  L+       SPE   ++ +++G+FS+         R      +K+ D   S +   
Sbjct: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395

Query: 789  EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 848
            E      +  D +K A+E+  +   + C  L   LN L  Q +   F N    L+     
Sbjct: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452

Query: 849  AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 902
             E  ++  +  T  S+P  ++ QL   K     L+  Q  +E+L K+    ++ +G+   
Sbjct: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512

Query: 903  GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
                +     +  +HF+ +   +  R   LQ           QE++ ++   + + E  L
Sbjct: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570

Query: 963  SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 1022
               Q+S     ++++ L     L+  +  Q+S L      V    + A S  +   Q + 
Sbjct: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630

Query: 1023 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 1080
             E+  R+++L       C + +E+ + L+K+    +  +    ++  F++ +   L    
Sbjct: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683

Query: 1081 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1138
               + +    +Q + L  +++  Q +L+++     ++ +        + +  ++ L   +
Sbjct: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743

Query: 1139 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
              + + V  R++      E+    +K +    +W+ + E      +    +  EL+K +E
Sbjct: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802

Query: 1199 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1233
             +K   ++   K   V+ +    T   N ++    P +Q                     
Sbjct: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862

Query: 1234 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
                   ++ ++  +   Y+ L   L+ + ++L+ +     E+        +WL   E  
Sbjct: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922

Query: 1289 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1343
            LK+ +  + P   E +    +S +  +   E N  +I+ + + L   G++    N +   
Sbjct: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980

Query: 1344 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1398
                  E  NSRW    E  V RQ+ LE+S       + +   ++  L   +  +     
Sbjct: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040

Query: 1399 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1451
              +D   +  + Q++Q  L   E      ++H Q  EAAQ +L+            QK+L
Sbjct: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097

Query: 1452 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1496
            Q ++ K+               +   K   +++ LQ+    +  V   L      S + E
Sbjct: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157

Query: 1497 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1548
             V+ QL     +   L ++  EV        E+ +  G Q ++        EL +R+  +
Sbjct: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210

Query: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
             L    L     +R  +L+  L  +++ ++  + L  WL     +  K   +      L 
Sbjct: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270

Query: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1666
            S++   +  QK + +     + I   GE+L   +  G+++  ++++L  L ++W  ++ +
Sbjct: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330

Query: 1667 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1725
              +  + L +  +  + +  +V+ +  WI      + E      P Q E  L R KA LN
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390

Query: 1726 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP---- 1779
            ++  R  +    + AA+++ N  +     +  + + +N    A++  ++    S+     
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450

Query: 1780 -LKELEQFNSDIQKLLEPLEAEIQ----------QGVNLKE------------------E 1810
             L+E ++   +I+K +E  + +++             NL++                   
Sbjct: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510

Query: 1811 DFNKDMNED--NEGTVKELLQRGDNLQQRITDERKREE-----IKIKQQLLQTKHNALKD 1863
            +F + + ED  +     +LL + +  QQ   + ++R       ++ K + +   H  +++
Sbjct: 3511 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE 3570

Query: 1864 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID------- 1916
            + SQ      E+        R  D L   ++D+   L  +   + + +  E +       
Sbjct: 3571 MFSQLADLDDELDGMG-AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE 3629

Query: 1917 ---RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1973
                +L   K EL A+ +Q   L+E G A      Q QL      +E  + + + LN A 
Sbjct: 3630 EGTLDLLGLKRELEALNKQCGKLTERGKA-----RQEQLELTLGRVEDFYRKLKGLNDAT 3684

Query: 1974 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFK 2033
                  E +  +                TE+  ++Q L + +                  
Sbjct: 3685 TAAEEAEALQWVVG--------------TEVEIINQQLADFKMF---------------- 3714

Query: 2034 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVK-LQEALSQLDFQWEKVNKMY 2092
            Q+E +  ++  LQQ +G            +QSA     V+ L+  + +++ +W  +NK  
Sbjct: 3715 QKEQVDPLQMKLQQVNG-------LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3767

Query: 2093 KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQ 2149
              R  +   ++    +F   ++    WL + E+ +   Q P + E+   K  ++E   LQ
Sbjct: 3768 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-ANQKPPSAEYKVVKAQIQEQKLLQ 3826

Query: 2150 DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2209
              +  R+  V  L A G  I Q +   D   +  +L SL  RW E+  + + R+K+LE+ 
Sbjct: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886

Query: 2210 KNILSEFQ---RDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2266
              +  +F      +++F+   E+   +A+      +  ++++++ + K L E++      
Sbjct: 3887 LVLAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2326
            + Q  + G    +S+  SP EQ  L  K+     ++ ++      K   ++  + +    
Sbjct: 3945 VHQAVKIGQS--LSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF 4002

Query: 2327 EKKLEDLEEQLNHLLLWLSPIRNQL-EIYNQPNQEGPFDVQETE-----IAVQAKQPDVE 2380
                ED  E LN    WL+ + ++L  ++ +  ++     Q  +       +  ++ +V+
Sbjct: 4003 G---EDEVEVLN----WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD 4055

Query: 2381 EILSKGQHLYKEKPATQP--VKRKLEDLSSEW--------KAVNRLLQE----------- 2419
            + +  GQ L K+    +   ++ KL+ + + +        KA+  L Q            
Sbjct: 4056 QAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTY 4115

Query: 2420 ------LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2473
                  LR  + +LA   T+ G SPT       Q    ++  + K  M   L+L+   + 
Sbjct: 4116 EELTGWLREVEEELA---TSGGQSPTGEQIPQFQ---QRQKELKKEVMEHRLVLD--TVN 4167

Query: 2474 DFNRAWTELTDWLSL--LDQVI---KSQRVMVGD-----LEDINEMIIK----------- 2512
            + +RA  EL  W +   LD+++     Q  +V D     +++I+  I +           
Sbjct: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE 4227

Query: 2513 ------------------------------QKATMQDLEQRRPQLEELITAAQNLKNKTS 2542
                                          QKA   D+ + +  ++EL +    +   T 
Sbjct: 4228 LAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG-TC 4286

Query: 2543 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2602
             +E +T++ ++ E +  Q++ +      R  +L        Q+ E  EE    + + RA 
Sbjct: 4287 GEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL 4346

Query: 2603 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA--LKLLRDYSADDTRKVH 2660
            +          + ++++  E +QL + + + + ++D    +   LK L     +   + +
Sbjct: 4347 IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 4406

Query: 2661 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 2720
               EN+ A    I + V +R  AL+E      Q     +K    L   ET  N+      
Sbjct: 4407 QKAENMYA---QIKEEVRQRALALDEAVSQSTQITEFHDKIEPML---ETLENLSSRLRM 4460

Query: 2721 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD---AVLLQR 2777
               +  +   ++E +   +    E+E     +  L    ++++   +G+D    A  +Q 
Sbjct: 4461 PPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD 4520

Query: 2778 RLDNMNFKWSELR----KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 2833
            +LD M F W +++    ++ +     LE +   W      +  LL  ++   D +     
Sbjct: 4521 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW----YDMAALLTTIKDTQDIVHDLES 4576

Query: 2834 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 2893
             G D   +++Q +     K E       +   LE +RI        G + ++       P
Sbjct: 4577 PGIDPSIIKQQVEAAETIKEETDG----LHEELEFIRIL-------GADLIFACGETEKP 4625

Query: 2894 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 2953
            E         +RK  +E+N  WE LN     W+ ++++  + +Q   +  D L       
Sbjct: 4626 E---------VRKSIDEMNNAWENLN---KTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673

Query: 2954 E--VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK---ENVSHVNDLARQLTT 3004
            +  VIK    P     +++++D L ++K  + E+   +   E ++H  +L  +  T
Sbjct: 4674 DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT 4729



 Score =  204 bits (518), Expect = 2e-51
 Identities = 416/2145 (19%), Positives = 855/2145 (39%), Gaps = 311/2145 (14%)

Query: 1037 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 1096
            +EH +KL   ++ LR I+   + ++     +++ L E    L  +++L+++LK    LVS
Sbjct: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859

Query: 1097 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1151
             +++ +   + S  +       +A  + A  L+  L  ++  W+    H    V   K  
Sbjct: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919

Query: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1210
            +   L +   L+  L ++  W+         +    +   D L   +++ +  K+   ++
Sbjct: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976

Query: 1211 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1257
            +A++  L   +   I++      P     + + L  L  ++Q +  +   +         
Sbjct: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036

Query: 1258 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1305
                    KTL++     H+    LE    W+ + E  L     +TT+      +++S +
Sbjct: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087

Query: 1306 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1353
              +  +L    +D  N+    A  + D  G M+E            + E+L     ++  
Sbjct: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147

Query: 1354 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1409
            L EE    QK LE+++ SA  QETEKS     + E+   ID  L    +      Q+   
Sbjct: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207

Query: 1410 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1467
               ++  S  +  + +L+    +    +A +++  Q ++ + + Q+      L  +  NF
Sbjct: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261

Query: 1468 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
                Q ++  LD+   +L   E + ++Q++ + +  +  +L +S +E+K           
Sbjct: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311

Query: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
              VQ  Q E  K L +                                  KE      WL
Sbjct: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333

Query: 1588 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1642
              ++ EL         P  L S +    +  +++   K  L+ +T  G+ +  +      
Sbjct: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393

Query: 1643 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1695
            GK+ +    LV+DKL      + A+ S   R    LN+LL  Q H   F  + D +  W+
Sbjct: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450

Query: 1696 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1746
                   + LL ++    P   Q++    K+L+ EL + +  V+  +  A ++M   G  
Sbjct: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510

Query: 1747 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1804
              DH R + E   S L+H F ++S+ +   ++S+  K + Q     Q + E LE+ +Q  
Sbjct: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563

Query: 1805 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1864
              +++    K ++  + G ++E L     L+Q I  ++   E   ++ + +    A    
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622

Query: 1865 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1903
             +  + K  E+S ++ Q                     ++  +  L + +++  + LAS 
Sbjct: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682

Query: 1904 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1946
             +P  +     ++I+E++ E++ ++E L+ +      LS  G A+ +            +
Sbjct: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742

Query: 1947 PTQIQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 2001
             T++Q + + RE ++   Q     FR+L    + T ++          P E S       
Sbjct: 2743 FTELQKTVKEREKDASSCQEQLDEFRKL----VRTFQKWLKETEGSIPPTETSMSAKELE 2798

Query: 2002 TEITHVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRID 2053
             +I H+   L          D  +K    E++  +  SL+N+       DS  ++   + 
Sbjct: 2799 KQIEHLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILP 2849

Query: 2054 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2113
             + S   +     T  +  ++Q  +S ++ ++EK+  +  +RQ      + +    H + 
Sbjct: 2850 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909

Query: 2114 KIFNQWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNAT 2165
                QWL   E+ L+       P   E  K      K +L EL+    + Q V   L   
Sbjct: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969

Query: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225
               ++   +  +A   ++    LN RW+   +    R+++LEE  + L+ FQ   ++   
Sbjct: 2970 ---LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026

Query: 2226 WLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2283
            WL E + +  +  PL       L  + +QV+ +++E   R+   +QLNE    +L     
Sbjct: 3027 WLMEKELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085

Query: 2284 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2343
                  +++ +L+  N +W++++  L  +  +I+  I    Q ++ L+DL E++  +   
Sbjct: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145

Query: 2344 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2403
            LS    Q  I  QP             AV+ +  +  EI S  + L  E    Q +  +L
Sbjct: 3146 LSV---QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 3190

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
              L  E    + L + L                   +TV L  Q +  ++ A  ++   +
Sbjct: 3191 SVLIGEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---N 3226

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
             L   + +   F + + EL  WL            +   LE +   + + +   + L Q 
Sbjct: 3227 RLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQH 3286

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
                E ++   ++L       E +  + +++  ++N W+E+ +   +R+ +L + ++ + 
Sbjct: 3287 SGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQ 3346

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVAN 2641
            ++    E+    +   +AK+   +    T+D +Q    +  +K +  ++ + ++ +++ N
Sbjct: 3347 KYQWHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403

Query: 2642 DLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKF 2701
              A  L+    AD+   +      IN +  ++ + +  +  +LEE  + L++F    E F
Sbjct: 3404 SAADILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESF 3459

Query: 2702 LAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 2761
                 + E   + L+           +K +++L  Q + LQ  +E   D   N    +Q 
Sbjct: 3460 KNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQG 3515

Query: 2762 ILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 2821
            ++       DA  L  + +    ++ E++++  +    +E   +   + H  ++E+   L
Sbjct: 3516 LVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQL 3575

Query: 2822 QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL 2881
               DDEL     IG D  ++Q Q                     +E VR+FL +  +  L
Sbjct: 3576 ADLDDELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKL 3614

Query: 2882 --EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQEL 2939
              E    E R +  EE   ++   L+++ E +N +  KL       Q +++ TL R+++ 
Sbjct: 3615 DIEASEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDF 3673

Query: 2940 QEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDL 2998
                  L+     AE  +     VG   ++ +   L   K  + E + PL+  +  VN L
Sbjct: 3674 YRKLKGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGL 3732

Query: 2999 ARQL-TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 3041
             + L  + G       L   +E++N RW  L   V  R+ QL EA
Sbjct: 3733 GQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777



 Score =  194 bits (492), Expect = 2e-48
 Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)

Query: 454  NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
            ++KL      L   E RT++++  PL  +L +L+  + Q KVL+ +L+     V+     
Sbjct: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864

Query: 514  VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 561
            V  +  S      A    ALE+  K L    +++      R +  Q+        +L + 
Sbjct: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924

Query: 562  QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 621
             +L        AW+  K   +N   +    D + +   LQ+   LK  + ++K  +  L 
Sbjct: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984

Query: 622  SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 670
               Q  +S        Q+    L        +    LE++ AQ+            +A+ 
Sbjct: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044

Query: 671  TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 723
             T   Q +     + +  + V   E+ L  H     Q++L      +     +  +I+ R
Sbjct: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104

Query: 724  LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 783
                 T   + +   E  ++  +  +  +E   + L+EK++    +  E++  LQ+ +R 
Sbjct: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154

Query: 784  AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 841
            AQ  +E+ V   +  ++ K +A+++L     E  + +   L+W+    +        L  
Sbjct: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210

Query: 842  LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 895
            +EQ++  +     +  T         P  +  Q ++ K     L   Q   I   +    
Sbjct: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270

Query: 896  ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 950
             L + G          L          +    +  +A  K++QT+ D L   ++ +    
Sbjct: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328

Query: 951  IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 1006
              +W+++SE +L       +  E +   L    +    +   +  L +++ + +++    
Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388

Query: 1007 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1062
                  K PSEI    + + ++   R+  L S+       L   + +  + QN   +L+ 
Sbjct: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448

Query: 1063 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
            WM    A V+  L +      D  +L++QL   KQ +  +++ Q     L  V     +I
Sbjct: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506

Query: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
            + E  P+     ET    + + +  +   +  R   L+  + ++ S+Q+ L  + + + +
Sbjct: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565

Query: 1176 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1235
             E+    +     +   +Q+A+    + K++  ++++ ++   E V   +  A       
Sbjct: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625

Query: 1236 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1295
            L+ +L  ++  ++ LC +   K  +L+++     E+  +L    +   E + ++  + N 
Sbjct: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684

Query: 1296 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1350
            P   ++I+     ++ L    ED    +  L   +T+    G  +D   +++ ++     
Sbjct: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742

Query: 1351 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1394
            + EL +    R+K              L+    +  +ETE S+   + S++   ++KQ+ 
Sbjct: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802

Query: 1395 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1439
               +   D A      ++I    TS E + +E     +QGK  +                
Sbjct: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862

Query: 1440 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1492
                +   Q  + DV++K+      L ++  + +  L   + +  E    L  LE+K   
Sbjct: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922

Query: 1493 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1538
                       + E V++Q          L +   +++ V +    ++      ++ EN 
Sbjct: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982

Query: 1539 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1598
            K++ E + +      E+      R++QLE+        +   + L  WL   ++ +    
Sbjct: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039

Query: 1599 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1655
             +   P+ L+++    +   KE E ++   + + E  + + T  G      + V+ +L  
Sbjct: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099

Query: 1656 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1708
            +N  W+ +T       S+ ++ +    +YQ+ ++   + V  + + +     +  + E  
Sbjct: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159

Query: 1709 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1763
            K Q +E     ++++L  +  +V   +     L    G     D  +K +E     L   
Sbjct: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217

Query: 1764 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1810
                + RI   +A++   ++ +Q   +++  L+          P+ A+++  Q    + E
Sbjct: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277

Query: 1811 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1870
            +F K +N+ + G+ + ++  G++L   +    ++  ++ +   L+     L    + R+ 
Sbjct: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336

Query: 1871 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1930
            +  +   +  +Y+   +DL+  ++D + K++ L    D     +++  L + K  LN V 
Sbjct: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393

Query: 1931 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1990
            ++   L    +A  +     +  +    I  + A   +   A    ++ +T  +  E+M 
Sbjct: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449

Query: 1991 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 2048
              +     ++      V  A   LE+   L +     K+ E L  Q+E L+ ++      
Sbjct: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504

Query: 2049 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 2105
              ++D + +     ++ A   +   ++  Q  ++Q +F   +V +         +  +E 
Sbjct: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560

Query: 2106 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2164
              +FH  ++ +F+Q     ++      I  + +  + +  +++++  + +   +   + A
Sbjct: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618

Query: 2165 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2217
            +  E   ++++    D   L+ +L +LN +    C +L++R K  +EQ  +    + +F 
Sbjct: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674

Query: 2218 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2271
            R L   N+     EEA+ +  +    G E ++  ++L   K+  +E   PL+   L+Q+N
Sbjct: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730

Query: 2272 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2331
              G  ++ SA    + Q  LE+ +++ N +W  +++ + ++  +++  +   G+ +  LE
Sbjct: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789

Query: 2332 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2385
             L       L WL+     +     P+ E       +QE ++    +  ++  V+ + ++
Sbjct: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842

Query: 2386 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2443
            G  + +  E    + +  +LE L S W     LL +  A+Q  L   L            
Sbjct: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887

Query: 2444 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2503
                 V+ K+                     F+     ++D+LS+ ++ + +   +    
Sbjct: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921

Query: 2504 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2563
              I + II+ KA  +D+E     + + +   Q+L + TS  E + +++++I+ +Q ++ E
Sbjct: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980

Query: 2564 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2623
            +Q+    +   L++ L ++  + E + E    L +   KL S     +  D + ++  + 
Sbjct: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040

Query: 2624 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2683
              L +++   + NVD A      LL+  + ++   +    + I   +  I    S+    
Sbjct: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100

Query: 2684 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2743
            LE+  +L  +F    E+   WL E E      ++           + + +  ++ ++L+ 
Sbjct: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154

Query: 2744 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2798
            E+  H  V   ++E S+ +L     R+ EG D  V       + N ++  +         
Sbjct: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208

Query: 2799 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2858
             ++A+  + ++   +    L W+     +L    PI  +      Q  V +AF       
Sbjct: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261

Query: 2859 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2918
                  +++ +R        + +++L+    E+      +  T +L+++ E +  ++E +
Sbjct: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308

Query: 2919 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2978
            +L +++   +++     + +  E  +EL   + +   +     P   +  + L+   E++
Sbjct: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367

Query: 2979 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3037
            + LR  IA  K ++  +  +  QL     +L+P     +E+   + + +   +++ VRQ
Sbjct: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422



 Score =  184 bits (467), Expect = 1e-45
 Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  ++Q ALE +LSWL   E+ +  Q   S + +VVK Q    +     L  
Sbjct: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 449
             +  V  +   G ++  + +L++ E+  +  Q+  L SRW  L  + A+ +KQ     VL
Sbjct: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889

Query: 450  MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
                ++  + ++D+L+ TE++      EP+G     +++Q+ +HK L+ED+E     V+ 
Sbjct: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947

Query: 510  LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 569
               +   +   +       L E++  L  R++ I      +  LL   L   +   E++ 
Sbjct: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007

Query: 570  LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 629
                WL+E ED ++ +    FK           LA L  ++  +K+++ +     Q LL 
Sbjct: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066

Query: 630  TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 689
                + V    E          D +  +    T   S+A+ T + +    T  ++     
Sbjct: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113

Query: 690  TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 743
            T E++   ++  +EEL     Q     QI    + +K L  ++ E H  +  T +E    
Sbjct: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172

Query: 744  SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 803
              E   +R       L    N       E+++ + D        + Q V+E    D+  Q
Sbjct: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215

Query: 804  ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 863
             S+Q         Q     L W+      +     ++ LEQ  TTA+  L++Q       
Sbjct: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259

Query: 864  TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
             A    +   KD ++ L   + +I     + Q   L+EK +  +    + ++  N     
Sbjct: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312

Query: 922  FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
             S+  AR +  Q + +     ++ ET   +  W++++   ++       D+E + Q+  E
Sbjct: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366

Query: 982  LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1031
            ++ L+ S+ E +     L  +   +KE++ +    +  KYQ          EE+  R   
Sbjct: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426

Query: 1032 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1085
            L      S+Q+ E   K+E  +  L  + + ++      AEVD               ++
Sbjct: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472

Query: 1086 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1141
            + +   +    +++ +QPS  ++   G+++      A+ + A++ ++ +L ++   W+ +
Sbjct: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532

Query: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
              +   R+      LE       D++ +   +   ++   + +     P  +++ VE  +
Sbjct: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592

Query: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
              KEE      +++ +      +I       +  ++K ++ +   ++ L      + + L
Sbjct: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652

Query: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
            E+      +    L+    WL+    KL T   +P    +++ V D L N M+  +    
Sbjct: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708

Query: 1322 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            Q +I  + L   G +           ++I E L      W  L E+   RQ  LE ++ +
Sbjct: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1428
              + + +L  +   LT  ++ L A      D   +  E  K   +++D+ +H+ ++E + 
Sbjct: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828

Query: 1429 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1474
            K       +   + A  + S+++   +  + V  K            Q+   F   +++ 
Sbjct: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888

Query: 1475 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1533
             + L  ++  L A +      E  + QL+  + LY  L   +     ++  GR  ++ + 
Sbjct: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948

Query: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
             + +  + ++ V  L+  ++ + +K+ ERK +LE+ L L+ + +  +     WL   +  
Sbjct: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008

Query: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1652
            L   S    + + + S++   K    E+   +  +  + + G  LK +  K++  L+++ 
Sbjct: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068

Query: 1653 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1712
            L  + S W  V  R+                            I+    LD++ +K+ +Q
Sbjct: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099

Query: 1713 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1772
              +  K+L   L D    +DS  +     ++N  D                         
Sbjct: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129

Query: 1773 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1832
              K  + L + ++F   +       +  I+ G  LKE+    + ++  +  + E+  + D
Sbjct: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187

Query: 1833 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1891
             +  +  + + + E  +              L S +   AL+    W Y+ + Q  +   
Sbjct: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233

Query: 1892 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1949
               D++  +  +    D  K+    +EL K+   +  ++R    L E+       V+   
Sbjct: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287

Query: 1950 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2006
             +LS RW  + +   ++  RL  A  Q    R+   M++      E +      L + T 
Sbjct: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347

Query: 2007 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2066
              Q+L++  +            E + K EE   ++  ++      + + H      ++  
Sbjct: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395

Query: 2067 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2126
              + R + +E L+     W K        Q R + ++ +       ++    W+  AE  
Sbjct: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444

Query: 2127 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2163
            L +     IP+N +  K     ++ +++E+         V +T                 
Sbjct: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504

Query: 2164 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2216
             + G + + Q +     IL +      ++  L+ RWQ+V     +R+++L +  + L E 
Sbjct: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564

Query: 2217 QRDLN-EFVLW 2226
            +   N +F +W
Sbjct: 5565 KEFANFDFDVW 5575



 Score = 91.3 bits (225), Expect = 2e-17
 Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)

Query: 331  GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 390
            G SL ++     ++  A ++++ WL  AE  L ++ EISND + +K Q   H+ +   L 
Sbjct: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146

Query: 391  AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              Q      ++ G  L     L ED + ++   +  +  +W+ +   S+E+Q  L   L+
Sbjct: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205

Query: 451  DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
                    L+ L DWL K E +    E++P+  DL+ +   +  HKV Q++L +    V 
Sbjct: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 568
             L      + E+S D  T  ++ QL+ L  RW  +C+ +  +   L+  L + +   +  
Sbjct: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322

Query: 569  CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 627
             +   WLSE E  +         D  E L SL          +E+K+  +    ++ + +
Sbjct: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380

Query: 628  LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 687
            L+      +T   + W+      ++ ++   ++   ++  A+  ++       + E +  
Sbjct: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437

Query: 688  VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 741
            +   E  L++  QE +P    + K      Q  ++   RK+ DVD +T+ +    R    
Sbjct: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494

Query: 742  LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 797
                 F    + G    L +     +  + + +A+  R  Q ++R  Q  +  +  +   
Sbjct: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554

Query: 798  ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 853
             D++ +  E       +F     + + W+ + ++ ++ F+ ++ + +    T + ++   
Sbjct: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614

Query: 854  --KIQPTTPSEPTAI 866
                 PTT  E TA+
Sbjct: 5615 LASKFPTTKLEMTAV 5629


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  370 bits (950), Expect = e-101
 Identities = 574/2872 (19%), Positives = 1190/2872 (41%), Gaps = 335/2872 (11%)

Query: 328  KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
            ++F   L E+E ++   +T+     LE+ +  L S  D   ++G +   VE +  +  + 
Sbjct: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326

Query: 383  EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 438
            E  +M++TA   QG+ G+IL      +G+  G  +  + TE+Q  M+ +N ++E L    
Sbjct: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386

Query: 439  MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 496
             E+Q +L  +L  M+  +++   +  WL   EE  + M+        E +K Q + +K  
Sbjct: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446

Query: 497  QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 556
              +LEQ   ++        V +  +G   T    ++     + W  I      RW    +
Sbjct: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496

Query: 557  ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 605
            + +  QR  EE      C  +A      WL EKE  +  +      D N + +  Q++  
Sbjct: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555

Query: 606  LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 664
            +  + E ++Q   +L    Q +L+   + S+ T + +  L +  + W  L  KL   ++Q
Sbjct: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615

Query: 665  ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIR-- 721
            I QA+  +TQ       + E V  V  R  +     Q  +   P   K+Q+   SEIR  
Sbjct: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRSD 2670

Query: 722  -KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA 780
             ++LD ++ E  + +    +VL   ++     +     +   +  +E   A++  +LQ A
Sbjct: 2671 LEQLDHEVKEAQT-LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAA 2729

Query: 781  SRSAQALVEQMVNEGVNADSIKQAS-----------EQLNSRWIE---FCQLLSERLNWL 826
              S Q   +QM +E       KQ+            E+L S+  E   F + L++     
Sbjct: 2730 LASTQQF-QQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788

Query: 827  EY---------------------QNNIIAFYNQLQQLEQMTTTAENWLK----------- 854
            E                      QN ++   N  ++L + T   ++ LK           
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 2848

Query: 855  -IQPTTP--SEPTAIKSQLKICKDEVNRLSGL---QPQIERLKIQSIALKEKGQGPMFL- 907
             ++   P   +  A  S+L++  D V   S L   +  +  ++ +   L+        L 
Sbjct: 2849 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 2908

Query: 908  ---DADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-----RYQETMSAIRTWVQQSE 959
               +AD     +    +  ++ A  +ELQ    +L  M      +QE+   I   V+ ++
Sbjct: 2909 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP--SEISRK 1017
             +L I   ++       + L +L+A Q  LQ  +  + YL    + + + AP  S+ S+ 
Sbjct: 2969 HQLEIFD-ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3027

Query: 1018 -YQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
             +Q+E  + E  + ++  ++   C  +E ++  + +    ++ +   +A++D  L     
Sbjct: 3028 LHQAEVAQQE--FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA 3085

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1136
               D++ L+ Q++  RL ++ I  ++  + +     + +  E        L+ EL+ LN 
Sbjct: 3086 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3145

Query: 1137 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPDELQK 1195
            Q   + ++  AR+E L+  L +     + L  +++  T AEE E L+     +     Q+
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205

Query: 1196 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ-EALKKELETLTTNYQWLCTRL 1254
              +     KE+    + K++ +      +I  A      + L+ ++E +   +  L  ++
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265

Query: 1255 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1314
              +   L+E      +    LE    WL + E  +   +      + +   +   + L R
Sbjct: 3266 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQR 3325

Query: 1315 HSEDNPNQIRILAQTLTDGGVMD--------ELINEELETFNSRWRELHEEAVRRQKLLE 1366
              +D    + +L     +GG +         E I  +LE+  SRW EL  +A  RQK LE
Sbjct: 3326 LLDDRKATVDMLQ---AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382

Query: 1367 QSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA---QKIQSDLTSHEIS 1423
              +  A++  ++   I + L+  +K+LA         A++ Q+    + ++ D+ +H   
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442

Query: 1424 LEEMKKHNQG-----KEAAQRVLSQ-IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477
            + +  K  Q        A Q VLS+ ID  Q +  ++  + R  +K A  +Q L  +++ 
Sbjct: 3443 VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI--QDRCCRKAALLDQALSNARLF 3500

Query: 1478 ----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
                      L EV+  L ++  K  +Q+V+  Q    + L + +   K  V+  IK G+
Sbjct: 3501 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 3560

Query: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
             ++++   E    + E++  +K  Y ++    ++  + LE+  +L+ K +     LT WL
Sbjct: 3561 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 3620

Query: 1588 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ----KVHLKSITEVGEALKTVLG 1643
               + EL    A  G  S    ++   +  QKE++K+    ++ L ++ EV  AL  ++ 
Sbjct: 3621 REVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 3676

Query: 1644 KKETLVEDKL-SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1702
             +     DKL S  N  +  V+    + ++ +    +  + ++Q  D    W+ +    L
Sbjct: 3677 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 3736

Query: 1703 D-----ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 1757
                    E+ +   +  V K    ++   +  +D      + +    G+  + +++ + 
Sbjct: 3737 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 3796

Query: 1758 SELNHRFAAIS-----HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ--GVNLKEE 1810
              L  ++ AIS        +  +A + + +  +   ++   +E   A I Q     +  E
Sbjct: 3797 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 3856

Query: 1811 DFNKDMNE---------DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1861
               +   E         +++  + +LL+ G  L+     E   EE ++ ++  Q   N  
Sbjct: 3857 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK-----ELNPEEGEMVEEKYQKAENMY 3911

Query: 1862 KDLRSQRRKKALEI------SHQWYQYKRQADDLLKCLDDIEKKLASLPE-PRDERKIKE 1914
              ++ + R++AL +      S Q  ++  + + +L+ L+++  +L   P  P +  KI+E
Sbjct: 3912 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 3971

Query: 1915 IDR-------ELQKKKEELNAVRRQAE-------GLSEDGAAMAVEPTQIQLSKRWREIE 1960
                      EL+K +    A++R+ E       G  +D AA  ++    Q+   W +I+
Sbjct: 3972 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4031

Query: 1961 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA 2020
            ++ A+ R + F  +  + E+              Y  +  LT I      + ++E     
Sbjct: 4032 AR-AEEREIKFLDVLELAEKFW------------YDMAALLTTIKDTQDIVHDLESPGID 4078

Query: 2021 PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQ 2080
            P +       + +Q E+ + IK+        ++ I       + +    E+ ++++++ +
Sbjct: 4079 PSI-------IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDE 4131

Query: 2081 LDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAK 2140
            ++  WE +NK +K+R  + + +++   ++   ++    WL      L  T  P   +   
Sbjct: 4132 MNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC-TMPPVGTDLNT 4190

Query: 2141 YKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSS-KTDASILQEKLGSLNLRWQEVC 2196
             K  L E+++    + Q+Q  +  LN  GE ++++++ +TD  I++E L  L   W+ + 
Sbjct: 4191 VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4250

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQLKEKLEQVK 2254
            ++++ R+ +LE     L +FQ  L E + WL   + +  A  P+  G  + ++ +L +  
Sbjct: 4251 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHH 4309

Query: 2255 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ- 2313
            +L  ++   Q  ++ +N+ G  +L S+  + ++   L ++L+  N  W  V +   E++ 
Sbjct: 4310 VLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367

Query: 2314 -------------GEIEAQIKDLGQLEKKL----------EDLEEQLNHLLLWLSPIRNQ 2350
                          EIE  + +L ++E +L          E   EQL+  +   S ++ +
Sbjct: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427

Query: 2351 LEIYNQPNQEGPFDV-QETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED---L 2406
             E YNQ   +G   +    +    +K      +L +  H+   K   +  K KLE+   L
Sbjct: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER--KSKLEEALNL 4485

Query: 2407 SSEWK-------------------------AVNRLLQELRAKQP---------DLAPGLT 2432
            ++E++                          +N +L ++   +          D    L 
Sbjct: 4486 ATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545

Query: 2433 TIG-----ASPTQTVTLVTQPVVTKETAISK-----LEMPSSLMLEVPALADFNRAWTEL 2482
              G      S  Q V L+   +V+ ++   K     +E   SL         F+ AW +L
Sbjct: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605

Query: 2483 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2542
             DWL   +  + S+  +  D + I   + K K   + L  ++P  +  I   + LK KT 
Sbjct: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 4665

Query: 2543 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2602
              E    + + +  ++++WD V      R+ +L E L  S Q+++A +     L +   +
Sbjct: 4666 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 4725

Query: 2603 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
            L   +     +D +   +   K   K+L +    V V      +L+ + S DDT  V   
Sbjct: 4726 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQ 4784

Query: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDAT 2719
             + ++  W ++ K    +++ LE+  +  + F   +   L WL+EAE T      L D T
Sbjct: 4785 LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT 4844

Query: 2720 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 2779
               + L D+   KE MK+ ++ + ++ +   +         +++ ++   D    ++  +
Sbjct: 4845 EALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPDCITTIKHWI 4894

Query: 2780 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGD 2837
              +  ++ E+   +   +  LE +  +       L+ELL W+Q  +  L +  Q PI  +
Sbjct: 4895 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQN 4954

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEGLEKLYQEPR 2889
               V+     H+ F  E+  K+P +           +E       E+   G  K   +P 
Sbjct: 4955 IDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP- 5013

Query: 2890 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              PP     + +     +  +++  W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 5014 -TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064



 Score =  351 bits (900), Expect = 9e-96
 Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)

Query: 384  GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 443
            G+ +DL  HQ RV N+ +  ++L  T K  E + +  QEQ++         +    E + 
Sbjct: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281

Query: 444  NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
            ++      +  ++L++        L+DW +K    T   E    G  LE+L        +
Sbjct: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330

Query: 496  LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 551
            ++      Q +  S+   V   V   +G H    L E    + D   ++  +     +R 
Sbjct: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390

Query: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
              LQ IL + + + +E      WL  KE+ +  +       + E + +  +    KA L 
Sbjct: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448

Query: 612  KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
            + +Q+  K+  +K+ L   L     +Q+ E W                    +I + + +
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489

Query: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
                 T+ TV                            ++RQ+   +          ++L
Sbjct: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522

Query: 732  HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
              W+   E ++      +       +  K++V  + +E   + ++ +  + +AQ ++   
Sbjct: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581

Query: 792  VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 850
             +  ++   +++  + +N +W+E    L+ R + ++        Y +L Q L +      
Sbjct: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641

Query: 851  NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 889
              L +Q    ++P A+K QL+                     +C DE++ L G Q   + 
Sbjct: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700

Query: 890  LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 947
            LK  ++++AL  +G   +  D       N  +   +  Q                ++Q+ 
Sbjct: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739

Query: 948  MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1005
               +RTW+   +++ +         E ++ +L E +  Q SL  Q SG Y +     E  
Sbjct: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798

Query: 1006 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1065
            +    P E  R  Q++  E++  W++LS +  +   +L++ M K +K Q H++ L  W+ 
Sbjct: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858

Query: 1066 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1125
            +    + E    L D   L+  L + + ++++++  +  L  +N     + N +E +   
Sbjct: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916

Query: 1126 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1185
             +  E   +N   D + +++ A+  +L+   ++    Q+    + + +  A+ + LE   
Sbjct: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975

Query: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1244
               +     K +E+++  +E  Q  E +V  L      ++  AP  +  + L  + E   
Sbjct: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035

Query: 1245 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1297
              +  +  R+N  C  +E   E    +H    E+ S L   +  L+ +    + T+++  
Sbjct: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095

Query: 1298 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1356
              E++   L+ +  L    E +  + R +   L + G +D L +  ELE  N +  +L E
Sbjct: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152

Query: 1357 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1396
                RQ+ LE ++                  +A+E E    ++   +  I++QLA    +
Sbjct: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212

Query: 1397 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1443
              ++VD  QM  +         IQS     D+   E  +EE+    +   K+ AQR+   
Sbjct: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270

Query: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
                  +LQ+  +          F+  L+     L + +  +   +  S E +VV++Q+ 
Sbjct: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318

Query: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563
                L + L + K+ V+M+   G +I Q  +  + +++  ++ +L+  + EL +K   R+
Sbjct: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378

Query: 1564 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623
            +QLE  L L+++  +    ++++L+ T+ +L     V    + +  ++   KA +++IE 
Sbjct: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438

Query: 1624 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1682
                +    ++G++L ++    E  ++ +K+  L + +  +  R      LL +   +  
Sbjct: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498

Query: 1683 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1735
             F ++   +  W+ + +  L     K    K+DVL R       L  E+ + +  VD   
Sbjct: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556

Query: 1736 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
                 L+         L++ ++  +  R+A I+  + + KA   L++  Q  +  Q   E
Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614

Query: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
             L   +++   ++EE             + +  QR   L++ + + R      +    + 
Sbjct: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665

Query: 1856 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1913
                AL +L   R ++ L+  +S    QYK  +D + + +D+I+  +      R ++  +
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720

Query: 1914 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1965
              D EL      ++K   L  +R + +   +  A + V+    I + +    ++  F+  
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777

Query: 1966 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2010
               F      Q   ++E+T  ++ +   + +              + + +      +S  
Sbjct: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837

Query: 2011 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2070
            + E   L+      A D E L +Q+E ++ +++S+ +    ID +  K    L+   P E
Sbjct: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896

Query: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2127
               ++E   + +  + ++ +  + R    D +V +  +   FH  I+   + L      L
Sbjct: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956

Query: 2128 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2180
            R    IP   E  K +  + + +     + + Q     L   GEE+I +S   D  +   
Sbjct: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014

Query: 2181 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2239
             +Q+KL  +   W+++  +  +R+ +  +   +  +F  D+   +  +++  +I      
Sbjct: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074

Query: 2240 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
            PG +  + K+++E  + + EE       L+ +   G  ++ +      E+ ++   + + 
Sbjct: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132

Query: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2355
            N  W  +++   E+  ++E  ++   Q +  L+ + + L++ ++ L    P+   L    
Sbjct: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192

Query: 2356 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2415
                E    ++E ++ V  +Q ++E++  +G+ + K+  AT    R +         +  
Sbjct: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237

Query: 2416 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2475
             L EL+    +L                        ++ A  + ++  +L+    AL  F
Sbjct: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270

Query: 2476 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2535
              A  EL  WL+  ++++ +QR + GD + I   + K      D+   +  +E +  A  
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330

Query: 2536 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2595
             L   ++  +A + +  R+E +   W+ V +  + R QQL   L+ +  +    E+    
Sbjct: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389

Query: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2654
            L +  ++L + K      +  ++++    +L   L+ + +T   + +   L LL    + 
Sbjct: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449

Query: 2655 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2714
               K       +   W  +  ++ ER++ LEE   L  +F   L++F+ WLT AE + N+
Sbjct: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509

Query: 2715 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2774
               A+    +L     V   +++ +    E+ AH D    LD+   + L+ L    D VL
Sbjct: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562

Query: 2775 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2834
            ++  L ++  +W ++ ++S+     L+ +  + K+ H + ++L+ WL+  +  L  +  I
Sbjct: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622

Query: 2835 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2894
              D   ++ Q   H+ F++ L  K+PV  +T+ T R                + + L PE
Sbjct: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2954
            + +Q +   L     EV  +W+ +   S + Q K++E L    +  +A   L   L + E
Sbjct: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723

Query: 2955 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3013
                  QPV GDL  D + + ++  K  + E+      V  +    R+L       + + 
Sbjct: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781

Query: 3014 LSTLEDLNTRWKL---LQVAVEDRVRQ 3037
               L++L+TRW     L V+ + R+ Q
Sbjct: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808



 Score =  296 bits (757), Expect = 3e-79
 Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)

Query: 343  RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            ++Q + + + +W+ + E  ++      +++D  V+++Q  T +    +L  HQ  V  + 
Sbjct: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995

Query: 401  QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 458
            ++   ++        +   VQE  + + S ++ L  +  E+ S L + +   Q+  + L+
Sbjct: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055

Query: 459  ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 518
             L   + + E+     +   L   +  ++  +  +  L++D+ +++  + +   MV    
Sbjct: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113

Query: 519  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 578
            E++     A L+ +L  +  R+  +C   +++   L+ +L + +         S  L + 
Sbjct: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169

Query: 579  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 638
             +  +++  +G +   ++    Q++  L  ++E +++++  L  L  +L S      + Q
Sbjct: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229

Query: 639  KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 696
              +             VQ L K   ++ + V   +   S  Q  + E    V T ++ L 
Sbjct: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276

Query: 697  KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
            K  +  +PP       +     E+ K+++   + L  W ++   V +     I  K  + 
Sbjct: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326

Query: 757  SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 810
             +L  ++ A +          Q  + S    V   V       + K  +E       +N 
Sbjct: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 861
            ++ +   +L ER      Q ++ A  N+++++ +   +   WL+ +          ++P+
Sbjct: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 915
            +   +K+Q +  K  +  L    P+I+++K     L       ++ +    +  +     
Sbjct: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            + +++      AR+++L+     L    +Q   S +R W+ + E  + +      D  ++
Sbjct: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1032
              +  ++Q +    + ++     L+   + +    P ++S    + Q E + I  +W +L
Sbjct: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605

Query: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
            + +L     ++++ + K  + Q  +Q L + +  V   L  +       E +K+QL++  
Sbjct: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665

Query: 1093 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1143
             + SD++ +   +          SV  G Q +K+E +     RLET    L    D    
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721

Query: 1144 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1203
            ++      L+  L  T   Q+   E+  W+   + +  +        + LQ  ++E +  
Sbjct: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777

Query: 1204 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1262
            ++   Q     +++     S++   PP  ++  L+ +L  L  +++ L  +   +   L+
Sbjct: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837

Query: 1263 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1322
            +      +   ++E    W+ + + K+          +  S +L S + ++   E   + 
Sbjct: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896

Query: 1323 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
            + IL   A  L +    DE  I +E    N     + EE   +   LE+  Q  +E ++S
Sbjct: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956

Query: 1379 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1434
               I++ +     QL  +  +  +  + +  ++ +  Q  L + E  ++ ++   QG   
Sbjct: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016

Query: 1435 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1481
                   A ++L Q +VAQ++  +V  +            +    F  R++E    L ++
Sbjct: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076

Query: 1482 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1541
               L  +     + + +QSQ+         +  +K ++E      R +++++ T +   L
Sbjct: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136

Query: 1542 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1601
               + AL     +L  +   R++QLE  L       +++  L +   A +     +  V 
Sbjct: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196

Query: 1602 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1658
                 ++ ++A  K  QKE ++  ++ L+ +  +G+ L    GK   +  +E  +  +N+
Sbjct: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1718
             W  +  +  + +  L E   H   F   ++ +  W+   + L+  + +K P  +  V+K
Sbjct: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314

Query: 1719 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1771
                    L+  L+D +  VD  + +   +  +     R+ +  Q+  L  R+  +    
Sbjct: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370

Query: 1772 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1808
               KA+   K+LE                  F S  +K L   EP+    A+IQQ + ++
Sbjct: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428

Query: 1809 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1868
             +   +D+ E++   V + ++ G +L   +T   ++  +  K   LQ +++ ++D   ++
Sbjct: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486

Query: 1869 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1923
                 +       +     ++L  L ++E KL+S+        +K+  +++  ++     
Sbjct: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539

Query: 1924 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
               EE+   ++  +   ++G A+  + T  ++     +++       +  +A I     +
Sbjct: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594

Query: 1981 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2040
             +  + +   L   +  STY      ++  L EVE+ L      +   E + + ++  K 
Sbjct: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649

Query: 2041 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
            +K  + +    +D ++    A L+      R  L + +S  + Q++ V+     R    D
Sbjct: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709

Query: 2101 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2157
             ++++ +++         W+ E ++ L      ++ ++   A+ +   K     I + + 
Sbjct: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768

Query: 2158 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2217
             +  L +   EI     +   ++LQEK  SL  +++ +    S+R  RLE  + ++++F 
Sbjct: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828

Query: 2218 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2276
                E   W+EE    IA +P      +QL+++ E+++ L E +   +  + +L + G  
Sbjct: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888

Query: 2277 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2333
            +     ++PEE + +E K ++    + ++   + ++     E  +Q   + +   K+E +
Sbjct: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945

Query: 2334 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2387
             E L +L   L + P+     +++      N+    ++++ + + +A +   EE++ + Q
Sbjct: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005

Query: 2388 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2435
               K+  A + ++ KL+ +   W+ +    +E   K             D+A  LTTI  
Sbjct: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064

Query: 2436 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2460
                     SP    +++ Q V   ET                              K E
Sbjct: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124

Query: 2461 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2499
            +  S+     A  + N+ W E                     + DWL      + +   +
Sbjct: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184

Query: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
              DL  + + + + K    ++ Q++ ++E+L    + +  K +++  R II + +  +++
Sbjct: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244

Query: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
             W+ + E + +R+ +L   L    Q+  A EE    L      L++ +        I+ +
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304

Query: 2620 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2679
            + +   L  D+   Q  V+  N    +LL   + DD   +    E +N  W S+ ++  E
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364

Query: 2680 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2739
            RE  L+ T +  Q F  ++E FL  LT  E+  +    A++    L ++   +E +    
Sbjct: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418

Query: 2740 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2799
            +L  +++A  + Y+ L +  + +L S + S      ++ +  +  KW  +  K    +S 
Sbjct: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478

Query: 2800 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2859
            LE + +       SLQE + WL L +  L+  +P       V  Q + H+ F  E+    
Sbjct: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538

Query: 2860 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2919
              I+                   +L Q   +L    + Q+V  L++     V + WEK+ 
Sbjct: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578

Query: 2920 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2976
              S +  R +D+  +R ++  EA  +L   L  AE    S   +    D +   L  H E
Sbjct: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638

Query: 2977 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3036
              K L G+  P+ +         ++ T L       + + L ++  +W  +     +R  
Sbjct: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696

Query: 3037 QLHEA 3041
            +L EA
Sbjct: 4697 KLEEA 4701



 Score =  245 bits (625), Expect = 7e-64
 Identities = 537/2938 (18%), Positives = 1125/2938 (38%), Gaps = 422/2938 (14%)

Query: 348  LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 405
            ++E+L W+ +     Q +   S   E    +    E  ++  +LT  + +V   ++    
Sbjct: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490

Query: 406  LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 454
             +     KLSE E+ ++ EQ+N LN  +  L   S  +   L          + L   QN
Sbjct: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550

Query: 455  ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 511
               Q+L++L  W+ + E      +      DL  L++     K LQ+D++      N  T
Sbjct: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604

Query: 512  HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 571
                VV +  G      +EE    L  R     R        L     +++ L EE  + 
Sbjct: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653

Query: 572  SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 628
               L E   +  +  T   K   E+  + +K+  L   +     S G+L +     + L 
Sbjct: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713

Query: 629  STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 686
                 K     T+ ++    +  + L ++ E   A+  + ++  Q  +  T   +     
Sbjct: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772

Query: 687  ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 735
                +T  EQ +++    E        L     + K+  T+  E++K L  D  E  SW+
Sbjct: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831

Query: 736  TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
             RSE  L+       SPE   ++ +++G+FS+         R      +K+ D   S + 
Sbjct: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891

Query: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 846
              E      +  D +K A+E+  +   + C  L   LN L  Q +   F N    L+   
Sbjct: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948

Query: 847  TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 902
               E  ++  +  T  S+P  ++ QL   K     L+  Q  +E+L K+    ++ +G+ 
Sbjct: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008

Query: 903  --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 960
                  +     +  +HF+ +   +  R   LQ           QE++ ++   + + E 
Sbjct: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066

Query: 961  KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1020
             L   Q+S     ++++ L     L+  +  Q+S L      V    + A S  +   Q 
Sbjct: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126

Query: 1021 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1080
            +  E+  R+++L       C + +E+ + L+K+    +  +    ++  F++ +   L  
Sbjct: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179

Query: 1081 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1136
                 + +    +Q + L  +++  Q +L+++     ++ +        + +  ++ L  
Sbjct: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239

Query: 1137 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1196
             +  + + V  R++      E+    +K +    +W+ + E      +    +  EL+K 
Sbjct: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298

Query: 1197 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1233
            +E +K   ++   K   V+ +    T   N ++    P +Q                   
Sbjct: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358

Query: 1234 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1286
                     ++ ++  +   Y+ L   L+ + ++L+ +     E+        +WL   E
Sbjct: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418

Query: 1287 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1343
              LK+ +  + P   E +    +S +  +   E N  +I+ + + L   G++    N + 
Sbjct: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476

Query: 1344 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1396
                    E  NSRW    E  V RQ+ LE+S       + +   ++  L   +  +   
Sbjct: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536

Query: 1397 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1449
                +D   +  + Q++Q  L   E      ++H Q  EAAQ +L+            QK
Sbjct: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593

Query: 1450 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1494
            +LQ ++ K+               +   K   +++ LQ+    +  V   L      S +
Sbjct: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653

Query: 1495 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1546
             E V+ QL     +   L ++  EV        E+ +  G Q ++        EL +R+ 
Sbjct: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
             + L    L     +R  +L+  L  +++ ++  + L  WL     +  K   +      
Sbjct: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1664
            L S++   +  QK + +     + I   GE+L   +  G+++  ++++L  L ++W  ++
Sbjct: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826

Query: 1665 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1723
             +  +  + L +  +  + +  +V+ +  WI      + E      P Q E  L R KA 
Sbjct: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886

Query: 1724 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP-- 1779
            LN++  R  +    + AA+++ N  +     +  + + +N    A++  ++    S+   
Sbjct: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM 2946

Query: 1780 ---LKELEQFNSDIQKLLEPLEAEIQ----------QGVNLKE----------------- 1809
               L+E ++   +I+K +E  + +++             NL++                 
Sbjct: 2947 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY 3006

Query: 1810 -EDFNKDMNED--NEGTVKELLQRGDNLQQRITDERKREE-----IKIKQQLLQTKHNAL 1861
              +F + + ED  +     +LL + +  QQ   + ++R       ++ K + +   H  +
Sbjct: 3007 LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3066

Query: 1862 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID----- 1916
            +++ SQ      E+        R  D L   ++D+   L  +   + + +  E +     
Sbjct: 3067 REMFSQLADLDDELDGMG-AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHML 3125

Query: 1917 -----RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNF 1971
                  +L   K EL A+ +Q   L+E G A      Q QL      +E  + + + LN 
Sbjct: 3126 EEEGTLDLLGLKRELEALNKQCGKLTERGKA-----RQEQLELTLGRVEDFYRKLKGLND 3180

Query: 1972 AQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDL 2031
            A       E +  +                TE+  ++Q L + +                
Sbjct: 3181 ATTAAEEAEALQWVVG--------------TEVEIINQQLADFKMF-------------- 3212

Query: 2032 FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVK-LQEALSQLDFQWEKVNK 2090
              Q+E +  ++  LQQ +G            +QSA     V+ L+  + +++ +W  +NK
Sbjct: 3213 --QKEQVDPLQMKLQQVNG-------LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE--- 2147
                R  +   ++    +F   ++    WL + E+ +   Q P + E+   K  ++E   
Sbjct: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-ANQKPPSAEYKVVKAQIQEQKL 3322

Query: 2148 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2207
            LQ  +  R+  V  L A G  I Q +   D   +  +L SL  RW E+  + + R+K+LE
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382

Query: 2208 EQKNILSEFQ---RDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQ 2264
            +   +  +F      +++F+   E+   +A+      +  ++++++ + K L E++    
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQIIRHKALEEDIENHA 3440

Query: 2265 GILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2324
              + Q  + G    +S+  SP EQ  L  K+     ++ ++      K   ++  + +  
Sbjct: 3441 TDVHQAVKIGQS--LSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498

Query: 2325 QLEKKLEDLEEQLNHLLLWLSPIRNQL-EIYNQPNQEGPFDVQETE-----IAVQAKQPD 2378
                  ED  E LN    WL+ + ++L  ++ +  ++     Q  +       +  ++ +
Sbjct: 3499 LFG---EDEVEVLN----WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551

Query: 2379 VEEILSKGQHLYKEKPATQP--VKRKLEDLSSEW--------KAVNRLLQE--------- 2419
            V++ +  GQ L K+    +   ++ KL+ + + +        KA+  L Q          
Sbjct: 3552 VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611

Query: 2420 --------LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471
                    LR  + +LA   T+ G SPT       Q    ++  + K  M   L+L+   
Sbjct: 3612 TYEELTGWLREVEEELA---TSGGQSPTGEQIPQFQ---QRQKELKKEVMEHRLVLD--T 3663

Query: 2472 LADFNRAWTELTDWLSL--LDQVI---KSQRVMVGD-----LEDINEMIIK--------- 2512
            + + +RA  EL  W +   LD+++     Q  +V D     +++I+  I +         
Sbjct: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723

Query: 2513 --------------------------------QKATMQDLEQRRPQLEELITAAQNLKNK 2540
                                            QKA   D+ + +  ++EL +    +   
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG- 3782

Query: 2541 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 2600
            T  +E +T++ ++ E +  Q++ +      R  +L        Q+ E  EE    + + R
Sbjct: 3783 TCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 3842

Query: 2601 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA--LKLLRDYSADDTRK 2658
            A +          + ++++  E +QL + + + + ++D    +   LK L     +   +
Sbjct: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902

Query: 2659 VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA 2718
             +   EN+ A    I + V +R  AL+E      Q     +K    L   ET  N+    
Sbjct: 3903 KYQKAENMYA---QIKEEVRQRALALDEAVSQSTQITEFHDKIEPML---ETLENLSSRL 3956

Query: 2719 TRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD---AVLL 2775
                 +  +   ++E +   +    E+E     +  L    ++++   +G+D    A  +
Sbjct: 3957 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEI 4016

Query: 2776 QRRLDNMNFKWSELR----KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
            Q +LD M F W +++    ++ +     LE +   W      +  LL  ++   D +   
Sbjct: 4017 QDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW----YDMAALLTTIKDTQDIVHDL 4072

Query: 2832 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2891
               G D   +++Q +     K E       +   LE +RI        G + ++      
Sbjct: 4073 ESPGIDPSIIKQQVEAAETIKEETDG----LHEELEFIRIL-------GADLIFACGETE 4121

Query: 2892 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2951
             PE         +RK  +E+N  WE LN     W+ ++++  + +Q   +  D L     
Sbjct: 4122 KPE---------VRKSIDEMNNAWENLN---KTWKERLEKLEDAMQAAVQYQDTLQAMFD 4169

Query: 2952 QAE--VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK---ENVSHVNDLARQLTT 3004
              +  VIK    P     +++++D L ++K  + E+   +   E ++H  +L  +  T
Sbjct: 4170 WLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT 4227



 Score =  241 bits (614), Expect = 1e-62
 Identities = 572/2968 (19%), Positives = 1186/2968 (39%), Gaps = 464/2968 (15%)

Query: 297  KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 356
            K+   T+A + +++   R P     L A        S  E E NL      + E+LSW+ 
Sbjct: 549  KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597

Query: 357  SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 412
              +  L+ + E  ND+  V+ Q  T +              ++ +LGS +    +  GK+
Sbjct: 598  EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646

Query: 413  SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 469
            S++  T   E +  L +++  L+  S   M    +LH+ +     + +     WL + EE
Sbjct: 647  SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701

Query: 470  RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 519
                   E L  D  D    +   +     L  +LE++Q    SL     ++       +
Sbjct: 702  -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754

Query: 520  SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 579
             + +  +AA++ QL+ +      +C   E     +++    +Q  ++ + L S +L   +
Sbjct: 755  QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806

Query: 580  DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 638
            D++ + ++    D N  LS L+ L  L+  +++K+Q    L   K  + S + ++K++ Q
Sbjct: 807  DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857

Query: 639  KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 695
                  D+             K+T  +       Q  +T     E V    +  T+ +++
Sbjct: 858  LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906

Query: 696  VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 738
                 E + P      PP  K  I + S + +          +L V+   L SW  + + 
Sbjct: 907  SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966

Query: 739  EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 784
              ++Q+      R              + ++ D L++  +++    A++ R L++   + 
Sbjct: 967  LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025

Query: 785  QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 829
            +A  + ++    N D              +I+   E+   R ++  Q L S R +   +Q
Sbjct: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085

Query: 830  NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 879
            +N +    Q      LQQL    + ++   +++L   P++ S PT ++S+L +  ++++ 
Sbjct: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144

Query: 880  LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 938
            + GL    + +LK   + ++      + +    +  +   + V +D+ A E    T+   
Sbjct: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200

Query: 939  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 998
                         R W+   + K S+   SV D EI + ++                   
Sbjct: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226

Query: 999  LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1056
                 ++MS+  P       +YQ +  +++ RW ++ +QL     +LE     L   +  
Sbjct: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283

Query: 1057 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
              TL KW+ E     +   P    DS +L +QL Q   L ++I+  Q  L+   +  Q+ 
Sbjct: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343

Query: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
                + ++  +L T    + +Q     Q+   ++  +    +       DL   +  +  
Sbjct: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397

Query: 1176 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1235
               ++++        D L++  EE K  +EE Q+   KVK L   V+++       A  +
Sbjct: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452

Query: 1236 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1292
              KE   +E      Q L   L  K + + E           ++ +  +L +   KL   
Sbjct: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502

Query: 1293 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1345
            E      ++ISE L++L        + + NQ++ L   L   T+   + +  N   ++LE
Sbjct: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557

Query: 1346 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
               S W    E A+   + +  +Q + + Q+ +  L  +Q+ +       A  + D    
Sbjct: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612

Query: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1462
              +    ++ Q+ L+  E++    K H Q KE  + +  +  VAQK+L++ V+   +   
Sbjct: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669

Query: 1463 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1505
            + +   + L E+K  +D              ++  +LP +E     S+E+  + +   + 
Sbjct: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728

Query: 1506 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1544
            + + ++  ++  + EM+    ++++ ++Q                      E  + L ++
Sbjct: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788

Query: 1545 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1604
            +  LK  Y+   A+     +Q++      +K  ++      WL  ++ EL         P
Sbjct: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848

Query: 1605 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1655
              L S +    +  +++   K  L+ +T  G+ +  +      GK+ +    LV+DKL  
Sbjct: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908

Query: 1656 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1708
                + A+ S   R    LN+LL  Q H   F  + D +  W+       + LL ++   
Sbjct: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965

Query: 1709 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1761
             P   Q++    K+L+ EL + +  V+  +  A ++M   G    DH R + E   S L+
Sbjct: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024

Query: 1762 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1821
            H F ++S+ +   ++S+  K + Q     Q + E LE+ +Q    +++    K ++  + 
Sbjct: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078

Query: 1822 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1881
            G ++E L     L+Q I  ++   E   ++ + +    A     +  + K  E+S ++ Q
Sbjct: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137

Query: 1882 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1915
                                 ++  +  L + +++  + LAS  +P  +     ++I+E+
Sbjct: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197

Query: 1916 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1963
            + E++ ++E L+ +      LS  G A+ +            + T++Q + + RE ++  
Sbjct: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257

Query: 1964 AQ-----FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLL 2018
             Q     FR+L    + T ++          P E S        +I H+   L       
Sbjct: 2258 CQEQLDEFRKL----VRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL------- 2306

Query: 2019 NAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVE 2070
               D  +K    E++  +  SL+N+       DS  ++   +  + S   +     T  +
Sbjct: 2307 --DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKD 2364

Query: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2130
              ++Q  +S ++ ++EK+  +  +RQ      + +    H +     QWL   E+ L+  
Sbjct: 2365 LTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSM 2424

Query: 2131 QI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQ 2182
                 P   E  K      K +L EL+    + Q V   L      ++   +  +A   +
Sbjct: 2425 DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWK 2481

Query: 2183 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEP 2240
            +    LN RW+   +    R+++LEE  + L+ FQ   ++   WL E + +  +  PL  
Sbjct: 2482 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541

Query: 2241 GKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2300
                 L  + +QV+ +++E   R+   +QLNE    +L           +++ +L+  N 
Sbjct: 2542 -DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ 2600

Query: 2301 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQE 2360
            +W++++  L  +  +I+  I    Q ++ L+DL E++  +   LS    Q  I  QP   
Sbjct: 2601 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE-- 2655

Query: 2361 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL 2420
                      AV+ +  +  EI S  + L  E    Q +  +L  L  E    + L + L
Sbjct: 2656 ----------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL 2705

Query: 2421 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2480
                               +TV L  Q +  ++ A  ++   + L   + +   F + + 
Sbjct: 2706 -------------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFD 2741

Query: 2481 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 2540
            EL  WL            +   LE +   + + +   + L Q     E ++   ++L   
Sbjct: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801

Query: 2541 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 2600
                E +  + +++  ++N W+E+ +   +R+ +L + ++ + ++    E+    +   +
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861

Query: 2601 AKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK 2658
            AK+   +    T+D +Q    +  +K +  ++ + ++ +++ N  A  L+    AD+   
Sbjct: 2862 AKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-G 2917

Query: 2659 VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA 2718
            +      IN +  ++ + +  +  +LEE  + L++F    E F     + E   + L+  
Sbjct: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIF 2974

Query: 2719 TRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 2778
                     +K +++L  Q + LQ  +E   D   N    +Q ++       DA  L  +
Sbjct: 2975 DALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQ 3030

Query: 2779 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 2838
             +    ++ E++++  +    +E   +   + H  ++E+   L   DDEL     IG D 
Sbjct: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3090

Query: 2839 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEER 2896
             ++Q Q                     +E VR+FL +  +  L  E    E R +  EE 
Sbjct: 3091 DSLQSQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEG 3129

Query: 2897 AQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVI 2956
              ++   L+++ E +N +  KL       Q +++ TL R+++       L+     AE  
Sbjct: 3130 TLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3188

Query: 2957 KGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNL 3014
            +     VG   ++ +   L   K  + E + PL+  +  VN L + L  + G       L
Sbjct: 3189 EALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGL 3247

Query: 3015 S-TLEDLNTRWKLLQVAVEDRVRQLHEA 3041
               +E++N RW  L   V  R+ QL EA
Sbjct: 3248 EHDMEEINARWNTLNKKVAQRIAQLQEA 3275



 Score =  208 bits (530), Expect = 7e-53
 Identities = 113/230 (49%), Positives = 149/230 (64%), Gaps = 5/230 (2%)

Query: 12  EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
           ER+ VQKKTFTKWVN    K  K HI +L+ DL+DG  L+ LLE L+G KLP+EKG  R 
Sbjct: 75  ERDRVQKKTFTKWVNKHLMKVRK-HINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133

Query: 72  HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
           H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ ++  +  +G 
Sbjct: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESG- 192

Query: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
             +  EK+LL W ++ T  Y  +   NF++ WSDG   NALIH +RPDL D   V   QS
Sbjct: 193 DMSAKEKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI-QS 250

Query: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
             + LE AF +A  +LG+ +LLD EDVD   PD+KS++ Y++S++   P+
Sbjct: 251 NRENLEQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299



 Score =  196 bits (498), Expect = 4e-49
 Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)

Query: 421  QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 477
            QE+ + L  RW  + +A +E +QS L  +   L + +     L  W+ +T  + ++M + 
Sbjct: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303

Query: 478  PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 518
                D   L  Q+ Q   L  ++E+ Q +++     S  +  +V D              
Sbjct: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363

Query: 519  --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 571
              +S G       ++ A+ ++   L  R+  +   T      + D L   +RL EE+ + 
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420

Query: 572  SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 613
                 EK++ V K+            +T G       K+  ++  ++ +  VL  +L  K
Sbjct: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477

Query: 614  KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 663
            K+ + +     Q  L       S  + K ++++  A    +    D   N +Q+L+   A
Sbjct: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537

Query: 664  -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 718
             Q  Q     Q +     + +  + V   E+ L  H     Q++L      +     +  
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597

Query: 719  EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 778
            +I+ R     T   + +   E  ++  +  +  +E   + L+EK++    +  E++  LQ
Sbjct: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647

Query: 779  DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 836
            + +R AQ  +E+ V   +  ++ K +A+++L     E  + +   L+W+    +      
Sbjct: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703

Query: 837  NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 890
              L  +EQ++  +     +  T         P  +  Q ++ K     L   Q   I   
Sbjct: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763

Query: 891  KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 945
            +     L + G          L          +    +  +A  K++QT+ D L   ++ 
Sbjct: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821

Query: 946  ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 1005
            +      +W+++SE +L       +  E +   L    +    +   +  L +++ + ++
Sbjct: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881

Query: 1006 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1057
            +          K PSEI    + + ++   R+  L S+       L   + +  + QN  
Sbjct: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941

Query: 1058 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 1110
             +L+ WM    A V+  L +      D  +L++QL   KQ +  +++ Q     L  V  
Sbjct: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999

Query: 1111 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1170
               +I+ E  P+     ET    + + +  +   +  R   L+  + ++ S+Q+ L  + 
Sbjct: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058

Query: 1171 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1230
            + + + E+    +     +   +Q+A+    + K++  ++++ ++   E V   +  A  
Sbjct: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118

Query: 1231 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1290
                 L+ +L  ++  ++ LC +   K  +L+++     E+  +L    +   E + ++ 
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177

Query: 1291 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1345
             + N P   ++I+     ++ L    ED    +  L   +T+    G  +D   +++ ++
Sbjct: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235

Query: 1346 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1389
                 + EL +    R+K              L+    +  +ETE S+   + S++   +
Sbjct: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295

Query: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1437
            +KQ+    +   D A      ++I    TS E + +E     +QGK  +           
Sbjct: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355

Query: 1438 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1489
                     +   Q  + DV++K+      L ++  + +  L   + +  E    L  LE
Sbjct: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415

Query: 1490 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1533
            +K              + E V++Q          L +   +++ V +    ++      +
Sbjct: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475

Query: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
            + EN K++ E + +      E+      R++QLE+        +   + L  WL   ++ 
Sbjct: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532

Query: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1650
            +     +   P+ L+++    +   KE E ++   + + E  + + T  G      + V+
Sbjct: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592

Query: 1651 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703
             +L  +N  W+ +T       S+ ++ +    +YQ+ ++   + V  + + +     +  
Sbjct: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652

Query: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1758
            + E  K Q +E     ++++L  +  +V   +     L    G     D  +K +E    
Sbjct: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710

Query: 1759 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1805
             L       + RI   +A++   ++ +Q   +++  L+          P+ A+++  Q  
Sbjct: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770

Query: 1806 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1865
              + E+F K +N+ + G+ + ++  G++L   +    ++  ++ +   L+     L    
Sbjct: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829

Query: 1866 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1925
            + R+ +  +   +  +Y+   +DL+  ++D + K++ L    D     +++  L + K  
Sbjct: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886

Query: 1926 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1985
            LN V ++   L    +A  +     +  +    I  + A   +   A    ++ +T  + 
Sbjct: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943

Query: 1986 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2043
             E+M   +     ++      V  A   LE+   L +     K+ E L  Q+E L+ ++ 
Sbjct: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002

Query: 2044 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
                   ++D + +     ++ A   +   ++  Q  ++Q +F   +V +         +
Sbjct: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053

Query: 2101 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2159
              +E   +FH  ++ +F+Q     ++      I  + +  + +  +++++  + +   + 
Sbjct: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111

Query: 2160 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2212
              + A+  E   ++++    D   L+ +L +LN +    C +L++R K  +EQ  +    
Sbjct: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167

Query: 2213 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2266
            + +F R L   N+     EEA+ +  +    G E ++  ++L   K+  +E   PL+   
Sbjct: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223

Query: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2326
            L+Q+N  G  ++ SA    + Q  LE+ +++ N +W  +++ + ++  +++  +   G+ 
Sbjct: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282

Query: 2327 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2380
            +  LE L       L WL+     +     P+ E       +QE ++    +  ++  V+
Sbjct: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335

Query: 2381 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2438
             + ++G  + +  E    + +  +LE L S W     LL +  A+Q  L   L       
Sbjct: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385

Query: 2439 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2498
                      V+ K+                     F+     ++D+LS+ ++ + +   
Sbjct: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414

Query: 2499 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2558
            +      I + II+ KA  +D+E     + + +   Q+L + TS  E + +++++I+ +Q
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473

Query: 2559 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2618
             ++ E+Q+    +   L++ L ++  + E + E    L +   KL S     +  D + +
Sbjct: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533

Query: 2619 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2678
            +  +   L +++   + NVD A      LL+  + ++   +    + I   +  I    S
Sbjct: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593

Query: 2679 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2738
            +    LE+  +L  +F    E+   WL E E      ++           + + +  ++ 
Sbjct: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647

Query: 2739 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2793
            ++L+ E+  H  V   ++E S+ +L     R+ EG D  V       + N ++  +    
Sbjct: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701

Query: 2794 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2853
                  ++A+  + ++   +    L W+     +L    PI  +      Q  V +AF  
Sbjct: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759

Query: 2854 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2913
                       +++ +R        + +++L+    E+      +  T +L+++ E +  
Sbjct: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801

Query: 2914 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2973
            ++E ++L +++   +++     + +  E  +EL   + +   +     P   +  + L+ 
Sbjct: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860

Query: 2974 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 3033
              E+++ LR  IA  K ++  +  +  QL     +L+P     +E+   + + +   +++
Sbjct: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916

Query: 3034 RVRQ 3037
             VRQ
Sbjct: 3917 EVRQ 3920



 Score =  184 bits (467), Expect = 1e-45
 Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  ++Q ALE +LSWL   E+ +  Q   S + +VVK Q    +     L  
Sbjct: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 449
             +  V  +   G ++  + +L++ E+  +  Q+  L SRW  L  + A+ +KQ     VL
Sbjct: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387

Query: 450  MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
                ++  + ++D+L+ TE++      EP+G     +++Q+ +HK L+ED+E     V+ 
Sbjct: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445

Query: 510  LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 569
               +   +   +       L E++  L  R++ I      +  LL   L   +   E++ 
Sbjct: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505

Query: 570  LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 629
                WL+E ED ++ +    FK           LA L  ++  +K+++ +     Q LL 
Sbjct: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564

Query: 630  TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 689
                + V    E          D +  +    T   S+A+ T + +    T  ++     
Sbjct: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611

Query: 690  TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 743
            T E++   ++  +EEL     Q     QI    + +K L  ++ E H  +  T +E    
Sbjct: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670

Query: 744  SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 803
              E   +R       L    N       E+++ + D        + Q V+E    D+  Q
Sbjct: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713

Query: 804  ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 863
             S+Q         Q     L W+      +     ++ LEQ  TTA+  L++Q       
Sbjct: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757

Query: 864  TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
             A    +   KD ++ L   + +I     + Q   L+EK +  +    + ++  N     
Sbjct: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810

Query: 922  FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
             S+  AR +  Q + +     ++ ET   +  W++++   ++       D+E + Q+  E
Sbjct: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864

Query: 982  LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1031
            ++ L+ S+ E +     L  +   +KE++ +    +  KYQ          EE+  R   
Sbjct: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924

Query: 1032 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1085
            L      S+Q+ E   K+E  +  L  + + ++      AEVD               ++
Sbjct: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970

Query: 1086 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1141
            + +   +    +++ +QPS  ++   G+++      A+ + A++ ++ +L ++   W+ +
Sbjct: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030

Query: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
              +   R+      LE       D++ +   +   ++   + +     P  +++ VE  +
Sbjct: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090

Query: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
              KEE      +++ +      +I       +  ++K ++ +   ++ L      + + L
Sbjct: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150

Query: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
            E+      +    L+    WL+    KL T   +P    +++ V D L N M+  +    
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206

Query: 1322 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            Q +I  + L   G +           ++I E L      W  L E+   RQ  LE ++ +
Sbjct: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1428
              + + +L  +   LT  ++ L A      D   +  E  K   +++D+ +H+ ++E + 
Sbjct: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326

Query: 1429 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1474
            K       +   + A  + S+++   +  + V  K            Q+   F   +++ 
Sbjct: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386

Query: 1475 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1533
             + L  ++  L A +      E  + QL+  + LY  L   +     ++  GR  ++ + 
Sbjct: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446

Query: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
             + +  + ++ V  L+  ++ + +K+ ERK +LE+ L L+ + +  +     WL   +  
Sbjct: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506

Query: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1652
            L   S    + + + S++   K    E+   +  +  + + G  LK +  K++  L+++ 
Sbjct: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566

Query: 1653 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1712
            L  + S W  V  R+                            I+    LD++ +K+ +Q
Sbjct: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597

Query: 1713 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1772
              +  K+L   L D    +DS  +     ++N  D                         
Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627

Query: 1773 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1832
              K  + L + ++F   +       +  I+ G  LKE+    + ++  +  + E+  + D
Sbjct: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685

Query: 1833 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1891
             +  +  + + + E  +              L S +   AL+    W Y+ + Q  +   
Sbjct: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731

Query: 1892 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1949
               D++  +  +    D  K+    +EL K+   +  ++R    L E+       V+   
Sbjct: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785

Query: 1950 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2006
             +LS RW  + +   ++  RL  A  Q    R+   M++      E +      L + T 
Sbjct: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845

Query: 2007 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2066
              Q+L++  +            E + K EE   ++  ++      + + H      ++  
Sbjct: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893

Query: 2067 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2126
              + R + +E L+     W K        Q R + ++ +       ++    W+  AE  
Sbjct: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942

Query: 2127 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2163
            L +     IP+N +  K     ++ +++E+         V +T                 
Sbjct: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002

Query: 2164 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2216
             + G + + Q +     IL +      ++  L+ RWQ+V     +R+++L +  + L E 
Sbjct: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062

Query: 2217 QRDLN-EFVLW 2226
            +   N +F +W
Sbjct: 5063 KEFANFDFDVW 5073



 Score = 91.3 bits (225), Expect = 2e-17
 Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)

Query: 331  GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 390
            G SL ++     ++  A ++++ WL  AE  L ++ EISND + +K Q   H+ +   L 
Sbjct: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644

Query: 391  AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              Q      ++ G  L     L ED + ++   +  +  +W+ +   S+E+Q  L   L+
Sbjct: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703

Query: 451  DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
                    L+ L DWL K E +    E++P+  DL+ +   +  HKV Q++L +    V 
Sbjct: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 568
             L      + E+S D  T  ++ QL+ L  RW  +C+ +  +   L+  L + +   +  
Sbjct: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820

Query: 569  CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 627
             +   WLSE E  +         D  E L SL          +E+K+  +    ++ + +
Sbjct: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878

Query: 628  LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 687
            L+      +T   + W+      ++ ++   ++   ++  A+  ++       + E +  
Sbjct: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935

Query: 688  VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 741
            +   E  L++  QE +P    + K      Q  ++   RK+ DVD +T+ +    R    
Sbjct: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992

Query: 742  LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 797
                 F    + G    L +     +  + + +A+  R  Q ++R  Q  +  +  +   
Sbjct: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052

Query: 798  ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 853
             D++ +  E       +F     + + W+ + ++ ++ F+ ++ + +    T + ++   
Sbjct: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112

Query: 854  --KIQPTTPSEPTAI 866
                 PTT  E TA+
Sbjct: 5113 LASKFPTTKLEMTAV 5127


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  325 bits (832), Expect = 7e-88
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 342  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 2219 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2267

Query: 402  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 2268 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2326

Query: 460  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 2327 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386

Query: 516  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 2387 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2444

Query: 555  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 2445 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2504

Query: 607  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 2505 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2560

Query: 667  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726
            Q +  +  +LTQ   +E                                           
Sbjct: 2561 QKLEESSNNLTQFQTVEA------------------------------------------ 2578

Query: 727  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 2579 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2634

Query: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 2635 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694

Query: 846  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2753

Query: 902  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 2754 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2809

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2869

Query: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929

Query: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2978

Query: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 2979 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3038

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 3039 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3098

Query: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 3099 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3158

Query: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 3159 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3215

Query: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 3216 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3266

Query: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 3267 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3326

Query: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 3327 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3386

Query: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 3387 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3446

Query: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3506

Query: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 3507 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3566

Query: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 3567 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3624

Query: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684

Query: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3744

Query: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 3745 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3804

Query: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 3805 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3860

Query: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 3861 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3915

Query: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3974

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4031

Query: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 4032 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4091

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 4092 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4151

Query: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 4152 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4207

Query: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 4208 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4263

Query: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 4264 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4307

Query: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 4308 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4345

Query: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 4346 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4404

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 4405 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4464

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 4465 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4524

Query: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 4525 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4578

Query: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 4579 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4637

Query: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 4638 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4697

Query: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 4698 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4738

Query: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 4739 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4796

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 4797 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4856

Query: 3028 QVAVEDRVRQLHEAH 3042
            Q  +E  +RQ  E H
Sbjct: 4857 QTRLEAALRQAEEFH 4871



 Score =  325 bits (832), Expect = 7e-88
 Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)

Query: 334  LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388
            + E    L + Q A EE   ++ WL  ++   T   Q     D E VK Q   ++ +  +
Sbjct: 2448 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2507

Query: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 444
            L  +   V  + +L  KL  T  L E+ +T      ++ +  ++S+W+ L   ++++Q  
Sbjct: 2508 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2562

Query: 445  LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 502
            L     +L   +  E  L  WL + E     +   PL  D   L  Q QQ ++L ++   
Sbjct: 2563 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2620

Query: 503  EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 560
             + +   LT     +    G+  +    ++EQL  +  +W ++     DR   +   ++K
Sbjct: 2621 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2680

Query: 561  WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 615
                T+ Q L  +   +  D  NK+ +     T     N+ L + QK+   K +++++K+
Sbjct: 2681 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2734

Query: 616  SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 673
             +    +L +DL + +K + +  +    L+   + + ++ QK E     +  A  ++   
Sbjct: 2735 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2794

Query: 674  ----------------------PSLTQTTVMETVT-------------------TVTTRE 692
                                  P   +  V+E++                    T+   E
Sbjct: 2795 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2854

Query: 693  QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 735
             +L+K    E      Q               K+R+  +   + K L     +  L  WI
Sbjct: 2855 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2914

Query: 736  TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 788
             + +  L+  +F +   EG  S  K K  ++++E  + F  ++  + +A +L+       
Sbjct: 2915 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2972

Query: 789  EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
            E + +E  +    +   +EQL+S+  +FC L +    + E+Q        QLQ  ++   
Sbjct: 2973 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3029

Query: 848  TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 888
              ++         +L +  T      A+K Q+ + K     L          S +  Q+E
Sbjct: 3030 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3089

Query: 889  RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 946
             +  +   L ++  +   FL+        HF+    ++ ++  E     D++ P+ R  E
Sbjct: 3090 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3148

Query: 947  TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1006
            T+   +  ++    KL     S            +   +  + +E    L  +   ++ +
Sbjct: 3149 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3201

Query: 1007 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
            SK+    + R  Q+  E++EG  K+L     E   KL+E    L+K + H ++       
Sbjct: 3202 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3249

Query: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1124
                   + P   ++E + +QL   ++   + I+ +Q     VN  GQ  I++ A+    
Sbjct: 3250 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3302

Query: 1125 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1184
              LE +L ++N +W  + ++V  R   L+  L      Q  L  +  WM   EE    + 
Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                    ++  ++E K  +     +++ V+++      +   A P  +  + K+L  L 
Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3422

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
            + ++ L  +   + + LE +     +    LE  N+WL  +E +L   E I   A ++ E
Sbjct: 3423 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3482

Query: 1305 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1356
             +   + L    +D  N  + L Q ++ G  +  L + E +        F+  W  E+ E
Sbjct: 3483 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539

Query: 1357 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1413
            ++  R +LL+Q++ +A+   E  + L+       DK     + D        Q+++   +
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3599

Query: 1414 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1467
            Q D+   + ++++   +  G E  ++    ++ + Q KL+ +  +++   K +       
Sbjct: 3600 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657

Query: 1468 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
            EQ LQ ++ +          LD+V++ L + ET+ ++ E           L K     K+
Sbjct: 3658 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3717

Query: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
             ++ + +    +++       + L++ V      Y  +   +T++ ++++  +  S++  
Sbjct: 3718 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3777

Query: 1578 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1637
            +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G  
Sbjct: 3778 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3837

Query: 1638 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1696
            + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W+ 
Sbjct: 3838 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3897

Query: 1697 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748
            +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G  
Sbjct: 3898 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3957

Query: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1803
                ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++   
Sbjct: 3958 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4013

Query: 1804 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1852
               ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  Q 
Sbjct: 4014 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4073

Query: 1853 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1908
             L         +  L  +R  K L++     ++      L+  + D +  +  L +P  D
Sbjct: 4074 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133

Query: 1909 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965
               +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +  
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4193

Query: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025
              +    +I  + EE M    +            Y   +  V   +      L +     
Sbjct: 4194 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4240

Query: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2084
             D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L   
Sbjct: 4241 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4300

Query: 2085 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2144
            W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +  
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4359

Query: 2145 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2201
            L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++   
Sbjct: 4360 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4419

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2259
            RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     +   
Sbjct: 4420 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4478

Query: 2260 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++E 
Sbjct: 4479 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4535

Query: 2319 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2372
             +    +    L+D        + WL+     L + ++P+       F + E ++    V
Sbjct: 4536 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588

Query: 2373 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2429
             + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R        
Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4640

Query: 2430 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2489
                                              SL         F+ AW++L +WL   
Sbjct: 4641 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4666

Query: 2490 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2549
            ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +    
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726

Query: 2550 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2609
            + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +  
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786

Query: 2610 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2669
               +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++  
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4845

Query: 2670 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2726
            W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R L 
Sbjct: 4846 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4905

Query: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2786
            D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  ++
Sbjct: 4906 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4955

Query: 2787 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2844
             E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+  
Sbjct: 4956 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5015

Query: 2845 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2887
               H+ F  E+  K+P +    +T +            I + ++   G ++     LY  
Sbjct: 5016 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5075

Query: 2888 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5076 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5121



 Score =  316 bits (809), Expect = 3e-85
 Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)

Query: 341  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 1868 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1927

Query: 401  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 1928 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1987

Query: 451  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 1988 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2047

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 2048 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2106

Query: 566  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 2107 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2160

Query: 621  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 680
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +  L +  
Sbjct: 2161 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2217

Query: 681  VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 735
              +  T + T+ Q L    + ++P     +  Q   +S     E +K L+V    LHS +
Sbjct: 2218 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2270

Query: 736  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 2271 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2307

Query: 795  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 2308 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2359

Query: 855  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 2360 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2418

Query: 902  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 2419 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2476

Query: 959  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 2477 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2536

Query: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2596

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 2597 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2656

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 2657 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2716

Query: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 2717 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2774

Query: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 2775 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2827

Query: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 2828 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2871

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 2872 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2903

Query: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 2904 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2956

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 2957 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3004

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 3005 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 3061 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3116

Query: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 3117 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3172

Query: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 3173 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3225

Query: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 3226 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3285

Query: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 3286 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345

Query: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3402

Query: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 3403 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3446

Query: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3503

Query: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 3504 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3563

Query: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 3564 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3623

Query: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 3624 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3683

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 3684 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3741

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 3742 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3794

Query: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 3795 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3854

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 3855 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3900

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 3901 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3943

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 3944 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3991

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 3992 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4048

Query: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 4049 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4108

Query: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 4109 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4164

Query: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 4165 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4220

Query: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 4221 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4262

Query: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 4263 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4321

Query: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 4322 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380

Query: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 4381 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4429



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 403  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 2402 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2461

Query: 455  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 2462 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2521

Query: 514  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 2522 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2581

Query: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 2582 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2640

Query: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 2641 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2683

Query: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 2684 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2725

Query: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 2726 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2765

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 2766 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2824

Query: 866  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 2825 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2884

Query: 924  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 2885 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2941

Query: 984  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 2942 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3001

Query: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 3002 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3053

Query: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 3054 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3113

Query: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 3114 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3173

Query: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 3174 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3225

Query: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 3226 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3285

Query: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 3286 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345

Query: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3402

Query: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 3403 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3461

Query: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 3462 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3521

Query: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 3522 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3581

Query: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 3582 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3641

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701

Query: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 3702 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761

Query: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 3762 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3821

Query: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 3822 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3880

Query: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 3881 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3940

Query: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 3941 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3996

Query: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 3997 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4056

Query: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 4057 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4103

Query: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 4104 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4160

Query: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 4161 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4217

Query: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 4218 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4277

Query: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 4278 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4332

Query: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 4333 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4385

Query: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 4386 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4413

Query: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 4414 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4464

Query: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 4465 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4523

Query: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 4524 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4583

Query: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 4584 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4643

Query: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 4644 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4697

Query: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 4698 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4757

Query: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 4758 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4811

Query: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 4812 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4856

Query: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 4857 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4916

Query: 2980 ALRGEI 2985
              R E+
Sbjct: 4917 EKRAEL 4922



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 345  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 2106 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2165

Query: 405  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 2166 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2223

Query: 463  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 2224 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2277

Query: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 2278 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2330

Query: 575  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 2331 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2376

Query: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 2377 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2426

Query: 691  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 2427 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2486

Query: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 2487 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2542

Query: 806  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 2543 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2602

Query: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 2603 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2662

Query: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 2663 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2720

Query: 981  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 2721 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2780

Query: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 2781 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2840

Query: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 2841 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2900

Query: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 2901 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2959

Query: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 2960 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3018

Query: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 3019 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3077

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 3078 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3135

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 3136 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3195

Query: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 3196 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3252

Query: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 3253 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3312

Query: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 3313 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3372

Query: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 3373 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3432

Query: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 3433 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3492

Query: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 3493 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3544

Query: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 3545 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3598

Query: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 3599 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655

Query: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 3656 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3712

Query: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 3713 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3771

Query: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3831

Query: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 3832 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3891

Query: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 3892 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3951

Query: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 3952 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4010

Query: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 4011 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4070

Query: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 4071 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4121

Query: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 4122 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4181

Query: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 4182 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4206

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 4207 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4260

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 4261 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4320

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 4321 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 4381 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4440

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 4441 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4494

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 4495 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4553

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 4554 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4613

Query: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 4614 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4664

Query: 2928 KIDETLERLQELQEATDELDLKLRQ 2952
            + +++L+   E+    D++  +L Q
Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQ 4689



 Score =  226 bits (576), Expect = 3e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 3328 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3387

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 3388 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3445

Query: 452  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 3446 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3499

Query: 510  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 3500 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3559

Query: 566  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 3560 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3619

Query: 612  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 3620 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3679

Query: 646  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 3680 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3739

Query: 702  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 3740 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3799

Query: 748  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 3800 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3855

Query: 807  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 3856 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3915

Query: 866  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3975

Query: 925  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 3976 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4033

Query: 985  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 4034 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093

Query: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4152

Query: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 4153 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4211

Query: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271

Query: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4331

Query: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4391

Query: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 4392 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4451

Query: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 4452 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4507

Query: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 4508 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4567

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 4568 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4627

Query: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 4628 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4687

Query: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 4688 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4747

Query: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 4748 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4807

Query: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 4808 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866

Query: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 4867 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4925

Query: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 4926 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4983

Query: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 4984 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5033

Query: 1934 EGLSEDGAAMAVEPTQIQ 1951
            + +++     A +P+ +Q
Sbjct: 5034 DKVTKTYKRRAADPSSLQ 5051



 Score =  219 bits (557), Expect = 5e-56
 Identities = 111/230 (48%), Positives = 152/230 (66%), Gaps = 5/230 (2%)

Query: 12  EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
           ER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  LP+EKG  R 
Sbjct: 61  ERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 119

Query: 72  HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
           H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ ++  ++    
Sbjct: 120 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGES 177

Query: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
           +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   QS
Sbjct: 178 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 236

Query: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
               LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 237 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 285



 Score =  205 bits (521), Expect = 8e-52
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 268  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3554

Query: 327  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 3555 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3601

Query: 387  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 3602 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3658

Query: 447  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 3659 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3716

Query: 505  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 3717 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3776

Query: 565  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 3777 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3836

Query: 605  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 3837 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3896

Query: 659  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 3897 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953

Query: 710  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 3954 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4013

Query: 754  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 4014 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072

Query: 803  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4132

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 4133 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4192

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 4193 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4246

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4306

Query: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 4307 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4366

Query: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 4367 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4426

Query: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 4427 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4486

Query: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 4487 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4546

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606

Query: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4666

Query: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 4667 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4715

Query: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 4716 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4775

Query: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 4776 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4834

Query: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 4835 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4894

Query: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 4895 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4954

Query: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5014

Query: 1720 LKAE 1723
            L AE
Sbjct: 5015 LIAE 5018



 Score =  178 bits (452), Expect = 8e-44
 Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)

Query: 456  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 1199 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1258

Query: 508  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 1259 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1318

Query: 558  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 1319 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1376

Query: 617  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 1377 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1430

Query: 677  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 1431 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1483

Query: 737  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 1484 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1533

Query: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 1534 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1576

Query: 857  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 1577 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1623

Query: 917  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 1624 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1668

Query: 975  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 1669 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1728

Query: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1729 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1788

Query: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1789 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1848

Query: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1849 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1908

Query: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1909 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1968

Query: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1969 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2028

Query: 1289 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1316
            L+ T+ + G                               +I + LD +    E+L +  
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2088

Query: 1317 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1364
             +   +++I   TLT    + + ++E L+   +    L E+             + +  +
Sbjct: 2089 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2145

Query: 1365 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1417
            LEQ I   Q +  +++  +++ +   D   A+ +  K+   +A+  + + K +  L    
Sbjct: 2146 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2205

Query: 1418 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
               T  E+     +K     E   + L+++DV  K + ++S             Q +QES
Sbjct: 2206 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2252

Query: 1475 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1532
                 E K HL  L +  K +    + S     +    +LS+   E+E  IK  ++ V  
Sbjct: 2253 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2312

Query: 1533 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1577
             Q +               KE  ++V  ++  +   +LG  + + K+  EK    + +++
Sbjct: 2313 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2372

Query: 1578 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1634
            K  N    L   ++A        +AV+   + L+ E   G AT  E       L SI + 
Sbjct: 2373 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2429

Query: 1635 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694
               +         L++DK++ LN+    +    EE   ++   QK  +T        TKW
Sbjct: 2430 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2482

Query: 1695 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1746
              Q      ++E  K Q +++  K  +AEL     KV   +D+   L+        A R 
Sbjct: 2483 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2538

Query: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1806
                  ++ +  ELN     I  + K  ++S  L + +   + +++ L  +E E+   V 
Sbjct: 2539 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2593

Query: 1807 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1852
            L     + +M       V+ LLQ               G  +  R  ++     I +K+Q
Sbjct: 2594 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2652

Query: 1853 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
            L  +  K ++L    S R     +A+  S Q+    R   D L  LD+  K  +SL    
Sbjct: 2653 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2710

Query: 1908 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1963
                + +     QK K+E+   ++Q   A+ L ED +A+  E   + +LS   R++E   
Sbjct: 2711 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2767

Query: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2020
              F+ +     + V+            L+ +   S    +++   QA L+    EQ  + 
Sbjct: 2768 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2816

Query: 2021 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079
            P     D  E L K     K+   +L   S   +   ++    L      E+  LQ  L+
Sbjct: 2817 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2873

Query: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2136
             +   W+  NK  K+R+ +   S+EK  ++   ++    W+ + +  L + +    P   
Sbjct: 2874 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2933

Query: 2137 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2196
            E++  K  LK LQ  + Q   +V  LN T   ++    + D  ++ ++  SL  +   V 
Sbjct: 2934 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 2990

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2239
            +QL  +K  LE       EFQ    E    L+ A       D++ S          +  +
Sbjct: 2991 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3050

Query: 2240 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2296
                Q LK +++  K L ++L +     K  ++    VL+      +E   L  ++    
Sbjct: 3051 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3106

Query: 2297 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2349
               +T LQ I       R +  +  E + ++  +  + +  E L++Q   +  +L  +  
Sbjct: 3107 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3166

Query: 2350 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2386
             +   +  N+     +   E +                        QA++  VE  + + 
Sbjct: 3167 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3226

Query: 2387 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2426
            +  Y +      + +K E+       +  E + +N+ L           + L+ KQ D  
Sbjct: 3227 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3286

Query: 2427 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2481
             L  GL    A  T T  L      V  +   ++K     +  L+   L    F  A   
Sbjct: 3287 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3346

Query: 2482 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2541
            L  W+   ++++ +Q+    + + +   I +QK   + L+ R+  +E +    + +   T
Sbjct: 3347 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3405

Query: 2542 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2601
            +    +  I  ++  + ++W+ +    + R +QL  +   + Q+ E  E   + L     
Sbjct: 3406 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3465

Query: 2602 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2661
            +L + +        ++++I + K L  D+     ++  A  +   L    S +D   V  
Sbjct: 3466 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3525

Query: 2662 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2721
              +     +  I ++   R   L++     + F  D  + + WL E            + 
Sbjct: 3526 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3576

Query: 2722 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2778
             +L       + L KQ  +L+   E       N+D+   N  ++L+   G D+ +++Q +
Sbjct: 3577 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3635

Query: 2779 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2837
            L+ +  ++ ++ K S ++   LE +    +RLH + +EL  WL   + E LS +  +   
Sbjct: 3636 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3695

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2894
              A Q Q    +  K+E K  + ++ S  E     L   P    EGLEK+  E       
Sbjct: 3696 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3749

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2952
            ER + V+  + ++ EE+    +   L S  + +  D  L  + E ++    L D++L Q
Sbjct: 3750 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3804



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 637  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 695

Query: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 696  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 755

Query: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 756  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 803


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  325 bits (832), Expect = 7e-88
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 342  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278

Query: 402  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337

Query: 460  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397

Query: 516  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455

Query: 555  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515

Query: 607  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571

Query: 667  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726
            Q +  +  +LTQ   +E                                           
Sbjct: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589

Query: 727  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645

Query: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705

Query: 846  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764

Query: 902  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880

Query: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940

Query: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989

Query: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109

Query: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169

Query: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226

Query: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277

Query: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337

Query: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397

Query: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457

Query: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517

Query: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577

Query: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635

Query: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695

Query: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755

Query: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815

Query: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871

Query: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926

Query: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042

Query: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162

Query: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218

Query: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274

Query: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318

Query: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356

Query: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535

Query: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589

Query: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648

Query: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708

Query: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749

Query: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867

Query: 3028 QVAVEDRVRQLHEAH 3042
            Q  +E  +RQ  E H
Sbjct: 4868 QTRLEAALRQAEEFH 4882



 Score =  325 bits (832), Expect = 7e-88
 Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)

Query: 334  LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388
            + E    L + Q A EE   ++ WL  ++   T   Q     D E VK Q   ++ +  +
Sbjct: 2459 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2518

Query: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 444
            L  +   V  + +L  KL  T  L E+ +T      ++ +  ++S+W+ L   ++++Q  
Sbjct: 2519 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2573

Query: 445  LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 502
            L     +L   +  E  L  WL + E     +   PL  D   L  Q QQ ++L ++   
Sbjct: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2631

Query: 503  EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 560
             + +   LT     +    G+  +    ++EQL  +  +W ++     DR   +   ++K
Sbjct: 2632 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2691

Query: 561  WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 615
                T+ Q L  +   +  D  NK+ +     T     N+ L + QK+   K +++++K+
Sbjct: 2692 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2745

Query: 616  SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 673
             +    +L +DL + +K + +  +    L+   + + ++ QK E     +  A  ++   
Sbjct: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805

Query: 674  ----------------------PSLTQTTVMETVT-------------------TVTTRE 692
                                  P   +  V+E++                    T+   E
Sbjct: 2806 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865

Query: 693  QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 735
             +L+K    E      Q               K+R+  +   + K L     +  L  WI
Sbjct: 2866 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2925

Query: 736  TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 788
             + +  L+  +F +   EG  S  K K  ++++E  + F  ++  + +A +L+       
Sbjct: 2926 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2983

Query: 789  EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
            E + +E  +    +   +EQL+S+  +FC L +    + E+Q        QLQ  ++   
Sbjct: 2984 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3040

Query: 848  TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 888
              ++         +L +  T      A+K Q+ + K     L          S +  Q+E
Sbjct: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3100

Query: 889  RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 946
             +  +   L ++  +   FL+        HF+    ++ ++  E     D++ P+ R  E
Sbjct: 3101 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3159

Query: 947  TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1006
            T+   +  ++    KL     S            +   +  + +E    L  +   ++ +
Sbjct: 3160 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3212

Query: 1007 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
            SK+    + R  Q+  E++EG  K+L     E   KL+E    L+K + H ++       
Sbjct: 3213 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3260

Query: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1124
                   + P   ++E + +QL   ++   + I+ +Q     VN  GQ  I++ A+    
Sbjct: 3261 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3313

Query: 1125 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1184
              LE +L ++N +W  + ++V  R   L+  L      Q  L  +  WM   EE    + 
Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                    ++  ++E K  +     +++ V+++      +   A P  +  + K+L  L 
Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
            + ++ L  +   + + LE +     +    LE  N+WL  +E +L   E I   A ++ E
Sbjct: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493

Query: 1305 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1356
             +   + L    +D  N  + L Q ++ G  +  L + E +        F+  W  E+ E
Sbjct: 3494 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550

Query: 1357 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1413
            ++  R +LL+Q++ +A+   E  + L+       DK     + D        Q+++   +
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3610

Query: 1414 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1467
            Q D+   + ++++   +  G E  ++    ++ + Q KL+ +  +++   K +       
Sbjct: 3611 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668

Query: 1468 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
            EQ LQ ++ +          LD+V++ L + ET+ ++ E           L K     K+
Sbjct: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3728

Query: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
             ++ + +    +++       + L++ V      Y  +   +T++ ++++  +  S++  
Sbjct: 3729 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3788

Query: 1578 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1637
            +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G  
Sbjct: 3789 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3848

Query: 1638 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1696
            + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W+ 
Sbjct: 3849 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3908

Query: 1697 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748
            +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G  
Sbjct: 3909 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3968

Query: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1803
                ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++   
Sbjct: 3969 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024

Query: 1804 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1852
               ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  Q 
Sbjct: 4025 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4084

Query: 1853 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1908
             L         +  L  +R  K L++     ++      L+  + D +  +  L +P  D
Sbjct: 4085 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144

Query: 1909 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965
               +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +  
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4204

Query: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025
              +    +I  + EE M    +            Y   +  V   +      L +     
Sbjct: 4205 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4251

Query: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2084
             D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L   
Sbjct: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4311

Query: 2085 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2144
            W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +  
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4370

Query: 2145 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2201
            L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++   
Sbjct: 4371 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4430

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2259
            RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     +   
Sbjct: 4431 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4489

Query: 2260 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++E 
Sbjct: 4490 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4546

Query: 2319 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2372
             +    +    L+D        + WL+     L + ++P+       F + E ++    V
Sbjct: 4547 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599

Query: 2373 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2429
             + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R        
Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4651

Query: 2430 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2489
                                              SL         F+ AW++L +WL   
Sbjct: 4652 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4677

Query: 2490 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2549
            ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +    
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737

Query: 2550 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2609
            + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +  
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797

Query: 2610 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2669
               +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++  
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4856

Query: 2670 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2726
            W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R L 
Sbjct: 4857 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4916

Query: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2786
            D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  ++
Sbjct: 4917 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4966

Query: 2787 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2844
             E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+  
Sbjct: 4967 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5026

Query: 2845 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2887
               H+ F  E+  K+P +    +T +            I + ++   G ++     LY  
Sbjct: 5027 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5086

Query: 2888 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5087 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132



 Score =  316 bits (809), Expect = 3e-85
 Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)

Query: 341  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938

Query: 401  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998

Query: 451  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117

Query: 566  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171

Query: 621  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 680
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +  L +  
Sbjct: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2228

Query: 681  VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 735
              +  T + T+ Q L    + ++P     +  Q   +S     E +K L+V    LHS +
Sbjct: 2229 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2281

Query: 736  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318

Query: 795  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370

Query: 855  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429

Query: 902  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487

Query: 959  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547

Query: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727

Query: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785

Query: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838

Query: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914

Query: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127

Query: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183

Query: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236

Query: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296

Query: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356

Query: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413

Query: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457

Query: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514

Query: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574

Query: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634

Query: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805

Query: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059

Query: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119

Query: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175

Query: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231

Query: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273

Query: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332

Query: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391

Query: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 403  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472

Query: 455  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532

Query: 514  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592

Query: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651

Query: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694

Query: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736

Query: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835

Query: 866  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895

Query: 924  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952

Query: 984  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012

Query: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064

Query: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124

Query: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184

Query: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236

Query: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296

Query: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356

Query: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413

Query: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472

Query: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532

Query: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592

Query: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712

Query: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772

Query: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832

Query: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891

Query: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951

Query: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007

Query: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067

Query: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114

Query: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171

Query: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228

Query: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288

Query: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343

Query: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396

Query: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424

Query: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475

Query: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534

Query: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594

Query: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654

Query: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708

Query: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768

Query: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822

Query: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867

Query: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927

Query: 2980 ALRGEI 2985
              R E+
Sbjct: 4928 EKRAEL 4933



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 345  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176

Query: 405  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234

Query: 463  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288

Query: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341

Query: 575  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387

Query: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437

Query: 691  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497

Query: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553

Query: 806  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613

Query: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673

Query: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731

Query: 981  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791

Query: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851

Query: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911

Query: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970

Query: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029

Query: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206

Query: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263

Query: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323

Query: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383

Query: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443

Query: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503

Query: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555

Query: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609

Query: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666

Query: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723

Query: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782

Query: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842

Query: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902

Query: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962

Query: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021

Query: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081

Query: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132

Query: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192

Query: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624

Query: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675

Query: 2928 KIDETLERLQELQEATDELDLKLRQ 2952
            + +++L+   E+    D++  +L Q
Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700



 Score =  226 bits (576), Expect = 3e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456

Query: 452  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510

Query: 510  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570

Query: 566  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630

Query: 612  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690

Query: 646  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750

Query: 702  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810

Query: 748  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866

Query: 807  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926

Query: 866  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986

Query: 925  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044

Query: 985  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104

Query: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163

Query: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222

Query: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282

Query: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342

Query: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402

Query: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462

Query: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518

Query: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638

Query: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698

Query: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758

Query: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818

Query: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877

Query: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936

Query: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994

Query: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044

Query: 1934 EGLSEDGAAMAVEPTQIQ 1951
            + +++     A +P+ +Q
Sbjct: 5045 DKVTKTYKRRAADPSSLQ 5062



 Score =  219 bits (557), Expect = 5e-56
 Identities = 111/230 (48%), Positives = 152/230 (66%), Gaps = 5/230 (2%)

Query: 12  EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
           ER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  LP+EKG  R 
Sbjct: 72  ERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130

Query: 72  HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
           H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ ++  ++    
Sbjct: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGES 188

Query: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
           +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   QS
Sbjct: 189 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 247

Query: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
               LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 248 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296



 Score =  205 bits (521), Expect = 8e-52
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 268  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565

Query: 327  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612

Query: 387  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669

Query: 447  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727

Query: 505  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787

Query: 565  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847

Query: 605  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907

Query: 659  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964

Query: 710  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024

Query: 754  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083

Query: 803  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317

Query: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377

Query: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437

Query: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497

Query: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617

Query: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677

Query: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726

Query: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786

Query: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845

Query: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905

Query: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965

Query: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025

Query: 1720 LKAE 1723
            L AE
Sbjct: 5026 LIAE 5029



 Score =  178 bits (452), Expect = 8e-44
 Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)

Query: 456  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269

Query: 508  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329

Query: 558  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387

Query: 617  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441

Query: 677  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494

Query: 737  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544

Query: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587

Query: 857  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634

Query: 917  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679

Query: 975  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739

Query: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799

Query: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859

Query: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919

Query: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979

Query: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039

Query: 1289 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1316
            L+ T+ + G                               +I + LD +    E+L +  
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2099

Query: 1317 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1364
             +   +++I   TLT    + + ++E L+   +    L E+             + +  +
Sbjct: 2100 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2156

Query: 1365 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1417
            LEQ I   Q +  +++  +++ +   D   A+ +  K+   +A+  + + K +  L    
Sbjct: 2157 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2216

Query: 1418 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
               T  E+     +K     E   + L+++DV  K + ++S             Q +QES
Sbjct: 2217 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2263

Query: 1475 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1532
                 E K HL  L +  K +    + S     +    +LS+   E+E  IK  ++ V  
Sbjct: 2264 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2323

Query: 1533 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1577
             Q +               KE  ++V  ++  +   +LG  + + K+  EK    + +++
Sbjct: 2324 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2383

Query: 1578 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1634
            K  N    L   ++A        +AV+   + L+ E   G AT  E       L SI + 
Sbjct: 2384 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2440

Query: 1635 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694
               +         L++DK++ LN+    +    EE   ++   QK  +T        TKW
Sbjct: 2441 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2493

Query: 1695 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1746
              Q      ++E  K Q +++  K  +AEL     KV   +D+   L+        A R 
Sbjct: 2494 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2549

Query: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1806
                  ++ +  ELN     I  + K  ++S  L + +   + +++ L  +E E+   V 
Sbjct: 2550 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2604

Query: 1807 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1852
            L     + +M       V+ LLQ               G  +  R  ++     I +K+Q
Sbjct: 2605 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2663

Query: 1853 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
            L  +  K ++L    S R     +A+  S Q+    R   D L  LD+  K  +SL    
Sbjct: 2664 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2721

Query: 1908 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1963
                + +     QK K+E+   ++Q   A+ L ED +A+  E   + +LS   R++E   
Sbjct: 2722 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2778

Query: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2020
              F+ +     + V+            L+ +   S    +++   QA L+    EQ  + 
Sbjct: 2779 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2827

Query: 2021 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079
            P     D  E L K     K+   +L   S   +   ++    L      E+  LQ  L+
Sbjct: 2828 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2884

Query: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2136
             +   W+  NK  K+R+ +   S+EK  ++   ++    W+ + +  L + +    P   
Sbjct: 2885 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2944

Query: 2137 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2196
            E++  K  LK LQ  + Q   +V  LN T   ++    + D  ++ ++  SL  +   V 
Sbjct: 2945 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 3001

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2239
            +QL  +K  LE       EFQ    E    L+ A       D++ S          +  +
Sbjct: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061

Query: 2240 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2296
                Q LK +++  K L ++L +     K  ++    VL+      +E   L  ++    
Sbjct: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3117

Query: 2297 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2349
               +T LQ I       R +  +  E + ++  +  + +  E L++Q   +  +L  +  
Sbjct: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3177

Query: 2350 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2386
             +   +  N+     +   E +                        QA++  VE  + + 
Sbjct: 3178 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3237

Query: 2387 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2426
            +  Y +      + +K E+       +  E + +N+ L           + L+ KQ D  
Sbjct: 3238 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3297

Query: 2427 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2481
             L  GL    A  T T  L      V  +   ++K     +  L+   L    F  A   
Sbjct: 3298 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3357

Query: 2482 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2541
            L  W+   ++++ +Q+    + + +   I +QK   + L+ R+  +E +    + +   T
Sbjct: 3358 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3416

Query: 2542 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2601
            +    +  I  ++  + ++W+ +    + R +QL  +   + Q+ E  E   + L     
Sbjct: 3417 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3476

Query: 2602 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2661
            +L + +        ++++I + K L  D+     ++  A  +   L    S +D   V  
Sbjct: 3477 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3536

Query: 2662 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2721
              +     +  I ++   R   L++     + F  D  + + WL E            + 
Sbjct: 3537 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3587

Query: 2722 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2778
             +L       + L KQ  +L+   E       N+D+   N  ++L+   G D+ +++Q +
Sbjct: 3588 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3646

Query: 2779 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2837
            L+ +  ++ ++ K S ++   LE +    +RLH + +EL  WL   + E LS +  +   
Sbjct: 3647 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3706

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2894
              A Q Q    +  K+E K  + ++ S  E     L   P    EGLEK+  E       
Sbjct: 3707 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3760

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2952
            ER + V+  + ++ EE+    +   L S  + +  D  L  + E ++    L D++L Q
Sbjct: 3761 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 648  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706

Query: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 707  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766

Query: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 767  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  325 bits (832), Expect = 7e-88
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 342  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 2368 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2416

Query: 402  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 2417 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2475

Query: 460  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 2476 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535

Query: 516  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 2536 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2593

Query: 555  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 2594 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2653

Query: 607  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 2654 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2709

Query: 667  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726
            Q +  +  +LTQ   +E                                           
Sbjct: 2710 QKLEESSNNLTQFQTVEA------------------------------------------ 2727

Query: 727  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 2728 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2783

Query: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 2784 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843

Query: 846  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2902

Query: 902  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 2903 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2958

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 3018

Query: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078

Query: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 3127

Query: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 3128 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3187

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 3188 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3247

Query: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 3248 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3307

Query: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 3308 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3364

Query: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 3365 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3415

Query: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 3416 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3475

Query: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 3476 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3535

Query: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 3536 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3595

Query: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3655

Query: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 3656 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3715

Query: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 3716 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3773

Query: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833

Query: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3893

Query: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 3894 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3953

Query: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 3954 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 4009

Query: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 4010 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 4064

Query: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 4123

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4180

Query: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 4181 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4240

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 4241 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4300

Query: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 4301 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4356

Query: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 4357 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4412

Query: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 4413 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4456

Query: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 4457 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4494

Query: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 4495 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4553

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 4554 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4613

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 4614 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4673

Query: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 4674 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4727

Query: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 4728 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4786

Query: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 4787 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4846

Query: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 4847 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4887

Query: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 4888 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4945

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 4946 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 5005

Query: 3028 QVAVEDRVRQLHEAH 3042
            Q  +E  +RQ  E H
Sbjct: 5006 QTRLEAALRQAEEFH 5020



 Score =  325 bits (832), Expect = 7e-88
 Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)

Query: 334  LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388
            + E    L + Q A EE   ++ WL  ++   T   Q     D E VK Q   ++ +  +
Sbjct: 2597 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2656

Query: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 444
            L  +   V  + +L  KL  T  L E+ +T      ++ +  ++S+W+ L   ++++Q  
Sbjct: 2657 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2711

Query: 445  LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 502
            L     +L   +  E  L  WL + E     +   PL  D   L  Q QQ ++L ++   
Sbjct: 2712 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2769

Query: 503  EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 560
             + +   LT     +    G+  +    ++EQL  +  +W ++     DR   +   ++K
Sbjct: 2770 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2829

Query: 561  WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 615
                T+ Q L  +   +  D  NK+ +     T     N+ L + QK+   K +++++K+
Sbjct: 2830 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2883

Query: 616  SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 673
             +    +L +DL + +K + +  +    L+   + + ++ QK E     +  A  ++   
Sbjct: 2884 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2943

Query: 674  ----------------------PSLTQTTVMETVT-------------------TVTTRE 692
                                  P   +  V+E++                    T+   E
Sbjct: 2944 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 3003

Query: 693  QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 735
             +L+K    E      Q               K+R+  +   + K L     +  L  WI
Sbjct: 3004 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 3063

Query: 736  TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 788
             + +  L+  +F +   EG  S  K K  ++++E  + F  ++  + +A +L+       
Sbjct: 3064 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 3121

Query: 789  EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
            E + +E  +    +   +EQL+S+  +FC L +    + E+Q        QLQ  ++   
Sbjct: 3122 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3178

Query: 848  TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 888
              ++         +L +  T      A+K Q+ + K     L          S +  Q+E
Sbjct: 3179 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3238

Query: 889  RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 946
             +  +   L ++  +   FL+        HF+    ++ ++  E     D++ P+ R  E
Sbjct: 3239 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3297

Query: 947  TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1006
            T+   +  ++    KL     S            +   +  + +E    L  +   ++ +
Sbjct: 3298 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3350

Query: 1007 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
            SK+    + R  Q+  E++EG  K+L     E   KL+E    L+K + H ++       
Sbjct: 3351 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3398

Query: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1124
                   + P   ++E + +QL   ++   + I+ +Q     VN  GQ  I++ A+    
Sbjct: 3399 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3451

Query: 1125 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1184
              LE +L ++N +W  + ++V  R   L+  L      Q  L  +  WM   EE    + 
Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                    ++  ++E K  +     +++ V+++      +   A P  +  + K+L  L 
Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3571

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
            + ++ L  +   + + LE +     +    LE  N+WL  +E +L   E I   A ++ E
Sbjct: 3572 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3631

Query: 1305 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1356
             +   + L    +D  N  + L Q ++ G  +  L + E +        F+  W  E+ E
Sbjct: 3632 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688

Query: 1357 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1413
            ++  R +LL+Q++ +A+   E  + L+       DK     + D        Q+++   +
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3748

Query: 1414 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1467
            Q D+   + ++++   +  G E  ++    ++ + Q KL+ +  +++   K +       
Sbjct: 3749 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806

Query: 1468 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
            EQ LQ ++ +          LD+V++ L + ET+ ++ E           L K     K+
Sbjct: 3807 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3866

Query: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
             ++ + +    +++       + L++ V      Y  +   +T++ ++++  +  S++  
Sbjct: 3867 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3926

Query: 1578 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1637
            +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G  
Sbjct: 3927 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3986

Query: 1638 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1696
            + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W+ 
Sbjct: 3987 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 4046

Query: 1697 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748
            +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G  
Sbjct: 4047 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 4106

Query: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1803
                ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++   
Sbjct: 4107 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4162

Query: 1804 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1852
               ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  Q 
Sbjct: 4163 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4222

Query: 1853 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1908
             L         +  L  +R  K L++     ++      L+  + D +  +  L +P  D
Sbjct: 4223 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282

Query: 1909 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965
               +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +  
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4342

Query: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025
              +    +I  + EE M    +            Y   +  V   +      L +     
Sbjct: 4343 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4389

Query: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2084
             D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L   
Sbjct: 4390 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4449

Query: 2085 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2144
            W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +  
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4508

Query: 2145 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2201
            L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++   
Sbjct: 4509 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4568

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2259
            RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     +   
Sbjct: 4569 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4627

Query: 2260 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++E 
Sbjct: 4628 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4684

Query: 2319 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2372
             +    +    L+D        + WL+     L + ++P+       F + E ++    V
Sbjct: 4685 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737

Query: 2373 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2429
             + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R        
Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4789

Query: 2430 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2489
                                              SL         F+ AW++L +WL   
Sbjct: 4790 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4815

Query: 2490 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2549
            ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +    
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875

Query: 2550 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2609
            + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +  
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935

Query: 2610 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2669
               +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++  
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4994

Query: 2670 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2726
            W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R L 
Sbjct: 4995 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 5054

Query: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2786
            D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  ++
Sbjct: 5055 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 5104

Query: 2787 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2844
             E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+  
Sbjct: 5105 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5164

Query: 2845 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2887
               H+ F  E+  K+P +    +T +            I + ++   G ++     LY  
Sbjct: 5165 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5224

Query: 2888 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5225 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5270



 Score =  316 bits (809), Expect = 3e-85
 Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)

Query: 341  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 2017 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 2076

Query: 401  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 2077 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 2136

Query: 451  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 2137 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2196

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 2197 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2255

Query: 566  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 2256 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2309

Query: 621  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 680
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +  L +  
Sbjct: 2310 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2366

Query: 681  VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 735
              +  T + T+ Q L    + ++P     +  Q   +S     E +K L+V    LHS +
Sbjct: 2367 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2419

Query: 736  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 2420 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2456

Query: 795  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 2457 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2508

Query: 855  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 2509 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2567

Query: 902  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 2568 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2625

Query: 959  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 2626 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2685

Query: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2745

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 2746 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2805

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 2806 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2865

Query: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 2866 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2923

Query: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 2924 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2976

Query: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 2977 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 3020

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 3021 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 3052

Query: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 3053 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 3105

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 3106 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3153

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 3154 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3209

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 3210 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3265

Query: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 3266 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3321

Query: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 3322 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3374

Query: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 3375 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3434

Query: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 3435 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494

Query: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3551

Query: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 3552 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3595

Query: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3652

Query: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 3653 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3712

Query: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 3713 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3772

Query: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 3773 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3832

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 3833 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3890

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 3891 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3943

Query: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 3944 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 4003

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 4004 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 4049

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 4050 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 4092

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 4093 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4140

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 4141 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4197

Query: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 4198 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4257

Query: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 4258 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4313

Query: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 4314 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4369

Query: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 4370 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4411

Query: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 4412 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4470

Query: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 4471 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4529

Query: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 4530 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4578



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 403  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 2551 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2610

Query: 455  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 2611 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2670

Query: 514  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 2671 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2730

Query: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 2731 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2789

Query: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 2790 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2832

Query: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 2833 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2874

Query: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 2875 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2914

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 2915 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2973

Query: 866  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 2974 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 3033

Query: 924  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 3034 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 3090

Query: 984  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 3091 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3150

Query: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 3151 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3202

Query: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 3203 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3262

Query: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 3263 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3322

Query: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 3323 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3374

Query: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 3375 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3434

Query: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 3435 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494

Query: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3551

Query: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 3552 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3610

Query: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 3611 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3670

Query: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 3671 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3730

Query: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 3731 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3790

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850

Query: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 3851 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910

Query: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 3911 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3970

Query: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 3971 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 4029

Query: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 4030 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 4089

Query: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 4090 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4145

Query: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 4146 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4205

Query: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 4206 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4252

Query: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 4253 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4309

Query: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 4310 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4366

Query: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 4367 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4426

Query: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 4427 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4481

Query: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 4482 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4534

Query: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 4535 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4562

Query: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 4563 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4613

Query: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 4614 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4672

Query: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 4673 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4732

Query: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 4733 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4792

Query: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 4793 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4846

Query: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 4847 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4906

Query: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 4907 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4960

Query: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 4961 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 5005

Query: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 5006 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 5065

Query: 2980 ALRGEI 2985
              R E+
Sbjct: 5066 EKRAEL 5071



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 345  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 2255 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2314

Query: 405  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 2315 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2372

Query: 463  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 2373 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2426

Query: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 2427 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2479

Query: 575  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 2480 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2525

Query: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 2526 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2575

Query: 691  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 2576 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2635

Query: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 2636 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2691

Query: 806  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 2692 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2751

Query: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 2752 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2811

Query: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 2812 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2869

Query: 981  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 2870 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2929

Query: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 2930 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2989

Query: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 2990 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 3049

Query: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 3050 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 3108

Query: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 3109 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3167

Query: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 3168 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3226

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 3227 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3284

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 3285 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3344

Query: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 3345 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3401

Query: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 3402 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3461

Query: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 3462 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3521

Query: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 3522 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3581

Query: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 3582 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3641

Query: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 3642 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3693

Query: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 3694 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3747

Query: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 3748 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804

Query: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 3805 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3861

Query: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 3862 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3920

Query: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3980

Query: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 3981 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 4040

Query: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 4041 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 4100

Query: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 4101 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4159

Query: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 4160 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4219

Query: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 4220 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4270

Query: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 4271 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4330

Query: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 4331 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4355

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 4356 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4409

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 4410 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4469

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 4470 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4529

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 4530 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4589

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 4590 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4643

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 4644 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4702

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 4703 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4762

Query: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 4763 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4813

Query: 2928 KIDETLERLQELQEATDELDLKLRQ 2952
            + +++L+   E+    D++  +L Q
Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQ 4838



 Score =  226 bits (576), Expect = 3e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 3477 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3536

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 3537 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3594

Query: 452  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 3595 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3648

Query: 510  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 3649 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3708

Query: 566  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 3709 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3768

Query: 612  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 3769 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3828

Query: 646  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 3829 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3888

Query: 702  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 3889 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3948

Query: 748  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 3949 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 4004

Query: 807  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 4005 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 4064

Query: 866  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 4124

Query: 925  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 4125 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4182

Query: 985  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 4183 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242

Query: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4301

Query: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 4302 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4360

Query: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420

Query: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4480

Query: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4540

Query: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 4541 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4600

Query: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 4601 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4656

Query: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 4657 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4716

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 4717 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4776

Query: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 4777 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4836

Query: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 4837 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4896

Query: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 4897 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4956

Query: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 4957 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015

Query: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 5016 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 5074

Query: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 5075 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 5132

Query: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 5133 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5182

Query: 1934 EGLSEDGAAMAVEPTQIQ 1951
            + +++     A +P+ +Q
Sbjct: 5183 DKVTKTYKRRAADPSSLQ 5200



 Score =  219 bits (557), Expect = 5e-56
 Identities = 111/230 (48%), Positives = 152/230 (66%), Gaps = 5/230 (2%)

Query: 12  EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
           ER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  LP+EKG  R 
Sbjct: 210 ERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 268

Query: 72  HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
           H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ ++  ++    
Sbjct: 269 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGES 326

Query: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
           +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   QS
Sbjct: 327 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 385

Query: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
               LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 386 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 434



 Score =  205 bits (521), Expect = 8e-52
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 268  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3703

Query: 327  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 3704 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3750

Query: 387  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 3751 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3807

Query: 447  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 3808 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3865

Query: 505  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 3866 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3925

Query: 565  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 3926 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3985

Query: 605  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 3986 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 4045

Query: 659  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 4046 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 4102

Query: 710  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 4103 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4162

Query: 754  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 4163 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221

Query: 803  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4281

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 4282 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4341

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 4342 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4395

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4455

Query: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 4456 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4515

Query: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 4516 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4575

Query: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 4576 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4635

Query: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 4636 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4695

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755

Query: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4815

Query: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 4816 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4864

Query: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 4865 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4924

Query: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 4925 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4983

Query: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 4984 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 5043

Query: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 5044 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 5103

Query: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5163

Query: 1720 LKAE 1723
            L AE
Sbjct: 5164 LIAE 5167



 Score =  178 bits (452), Expect = 8e-44
 Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)

Query: 456  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 1348 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1407

Query: 508  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 1408 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1467

Query: 558  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 1468 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1525

Query: 617  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 1526 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579

Query: 677  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 1580 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1632

Query: 737  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 1633 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1682

Query: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 1683 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1725

Query: 857  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 1726 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1772

Query: 917  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 1773 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1817

Query: 975  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 1818 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1877

Query: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1878 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1937

Query: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1938 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1997

Query: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1998 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 2057

Query: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 2058 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 2117

Query: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 2118 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2177

Query: 1289 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1316
            L+ T+ + G                               +I + LD +    E+L +  
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2237

Query: 1317 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1364
             +   +++I   TLT    + + ++E L+   +    L E+             + +  +
Sbjct: 2238 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2294

Query: 1365 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1417
            LEQ I   Q +  +++  +++ +   D   A+ +  K+   +A+  + + K +  L    
Sbjct: 2295 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2354

Query: 1418 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
               T  E+     +K     E   + L+++DV  K + ++S             Q +QES
Sbjct: 2355 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2401

Query: 1475 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1532
                 E K HL  L +  K +    + S     +    +LS+   E+E  IK  ++ V  
Sbjct: 2402 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2461

Query: 1533 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1577
             Q +               KE  ++V  ++  +   +LG  + + K+  EK    + +++
Sbjct: 2462 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2521

Query: 1578 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1634
            K  N    L   ++A        +AV+   + L+ E   G AT  E       L SI + 
Sbjct: 2522 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2578

Query: 1635 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694
               +         L++DK++ LN+    +    EE   ++   QK  +T        TKW
Sbjct: 2579 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2631

Query: 1695 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1746
              Q      ++E  K Q +++  K  +AEL     KV   +D+   L+        A R 
Sbjct: 2632 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2687

Query: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1806
                  ++ +  ELN     I  + K  ++S  L + +   + +++ L  +E E+   V 
Sbjct: 2688 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2742

Query: 1807 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1852
            L     + +M       V+ LLQ               G  +  R  ++     I +K+Q
Sbjct: 2743 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2801

Query: 1853 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
            L  +  K ++L    S R     +A+  S Q+    R   D L  LD+  K  +SL    
Sbjct: 2802 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2859

Query: 1908 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1963
                + +     QK K+E+   ++Q   A+ L ED +A+  E   + +LS   R++E   
Sbjct: 2860 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2916

Query: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2020
              F+ +     + V+            L+ +   S    +++   QA L+    EQ  + 
Sbjct: 2917 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2965

Query: 2021 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079
            P     D  E L K     K+   +L   S   +   ++    L      E+  LQ  L+
Sbjct: 2966 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 3022

Query: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2136
             +   W+  NK  K+R+ +   S+EK  ++   ++    W+ + +  L + +    P   
Sbjct: 3023 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 3082

Query: 2137 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2196
            E++  K  LK LQ  + Q   +V  LN T   ++    + D  ++ ++  SL  +   V 
Sbjct: 3083 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 3139

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2239
            +QL  +K  LE       EFQ    E    L+ A       D++ S          +  +
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199

Query: 2240 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2296
                Q LK +++  K L ++L +     K  ++    VL+      +E   L  ++    
Sbjct: 3200 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3255

Query: 2297 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2349
               +T LQ I       R +  +  E + ++  +  + +  E L++Q   +  +L  +  
Sbjct: 3256 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3315

Query: 2350 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2386
             +   +  N+     +   E +                        QA++  VE  + + 
Sbjct: 3316 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3375

Query: 2387 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2426
            +  Y +      + +K E+       +  E + +N+ L           + L+ KQ D  
Sbjct: 3376 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3435

Query: 2427 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2481
             L  GL    A  T T  L      V  +   ++K     +  L+   L    F  A   
Sbjct: 3436 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3495

Query: 2482 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2541
            L  W+   ++++ +Q+    + + +   I +QK   + L+ R+  +E +    + +   T
Sbjct: 3496 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3554

Query: 2542 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2601
            +    +  I  ++  + ++W+ +    + R +QL  +   + Q+ E  E   + L     
Sbjct: 3555 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3614

Query: 2602 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2661
            +L + +        ++++I + K L  D+     ++  A  +   L    S +D   V  
Sbjct: 3615 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3674

Query: 2662 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2721
              +     +  I ++   R   L++     + F  D  + + WL E            + 
Sbjct: 3675 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3725

Query: 2722 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2778
             +L       + L KQ  +L+   E       N+D+   N  ++L+   G D+ +++Q +
Sbjct: 3726 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3784

Query: 2779 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2837
            L+ +  ++ ++ K S ++   LE +    +RLH + +EL  WL   + E LS +  +   
Sbjct: 3785 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3844

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2894
              A Q Q    +  K+E K  + ++ S  E     L   P    EGLEK+  E       
Sbjct: 3845 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3898

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2952
            ER + V+  + ++ EE+    +   L S  + +  D  L  + E ++    L D++L Q
Sbjct: 3899 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3953



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 786  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 844

Query: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 845  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 904

Query: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 905  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 952


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  325 bits (832), Expect = 7e-88
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 342  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238

Query: 402  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297

Query: 460  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357

Query: 516  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415

Query: 555  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475

Query: 607  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531

Query: 667  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726
            Q +  +  +LTQ   +E                                           
Sbjct: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549

Query: 727  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605

Query: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665

Query: 846  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724

Query: 902  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840

Query: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900

Query: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949

Query: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069

Query: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129

Query: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186

Query: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237

Query: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297

Query: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357

Query: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417

Query: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477

Query: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537

Query: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595

Query: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655

Query: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715

Query: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775

Query: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831

Query: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886

Query: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002

Query: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122

Query: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178

Query: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234

Query: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278

Query: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316

Query: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495

Query: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549

Query: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608

Query: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668

Query: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709

Query: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827

Query: 3028 QVAVEDRVRQLHEAH 3042
            Q  +E  +RQ  E H
Sbjct: 4828 QTRLEAALRQAEEFH 4842



 Score =  325 bits (832), Expect = 7e-88
 Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)

Query: 334  LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388
            + E    L + Q A EE   ++ WL  ++   T   Q     D E VK Q   ++ +  +
Sbjct: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478

Query: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 444
            L  +   V  + +L  KL  T  L E+ +T      ++ +  ++S+W+ L   ++++Q  
Sbjct: 2479 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2533

Query: 445  LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 502
            L     +L   +  E  L  WL + E     +   PL  D   L  Q QQ ++L ++   
Sbjct: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2591

Query: 503  EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 560
             + +   LT     +    G+  +    ++EQL  +  +W ++     DR   +   ++K
Sbjct: 2592 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2651

Query: 561  WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 615
                T+ Q L  +   +  D  NK+ +     T     N+ L + QK+   K +++++K+
Sbjct: 2652 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2705

Query: 616  SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 673
             +    +L +DL + +K + +  +    L+   + + ++ QK E     +  A  ++   
Sbjct: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765

Query: 674  ----------------------PSLTQTTVMETVT-------------------TVTTRE 692
                                  P   +  V+E++                    T+   E
Sbjct: 2766 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825

Query: 693  QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 735
             +L+K    E      Q               K+R+  +   + K L     +  L  WI
Sbjct: 2826 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2885

Query: 736  TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 788
             + +  L+  +F +   EG  S  K K  ++++E  + F  ++  + +A +L+       
Sbjct: 2886 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2943

Query: 789  EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
            E + +E  +    +   +EQL+S+  +FC L +    + E+Q        QLQ  ++   
Sbjct: 2944 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3000

Query: 848  TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 888
              ++         +L +  T      A+K Q+ + K     L          S +  Q+E
Sbjct: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3060

Query: 889  RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 946
             +  +   L ++  +   FL+        HF+    ++ ++  E     D++ P+ R  E
Sbjct: 3061 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3119

Query: 947  TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1006
            T+   +  ++    KL     S            +   +  + +E    L  +   ++ +
Sbjct: 3120 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3172

Query: 1007 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
            SK+    + R  Q+  E++EG  K+L     E   KL+E    L+K + H ++       
Sbjct: 3173 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3220

Query: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1124
                   + P   ++E + +QL   ++   + I+ +Q     VN  GQ  I++ A+    
Sbjct: 3221 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3273

Query: 1125 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1184
              LE +L ++N +W  + ++V  R   L+  L      Q  L  +  WM   EE    + 
Sbjct: 3274 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3333

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                    ++  ++E K  +     +++ V+++      +   A P  +  + K+L  L 
Sbjct: 3334 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3393

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
            + ++ L  +   + + LE +     +    LE  N+WL  +E +L   E I   A ++ E
Sbjct: 3394 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3453

Query: 1305 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1356
             +   + L    +D  N  + L Q ++ G  +  L + E +        F+  W  E+ E
Sbjct: 3454 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510

Query: 1357 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1413
            ++  R +LL+Q++ +A+   E  + L+       DK     + D        Q+++   +
Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3570

Query: 1414 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1467
            Q D+   + ++++   +  G E  ++    ++ + Q KL+ +  +++   K +       
Sbjct: 3571 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628

Query: 1468 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
            EQ LQ ++ +          LD+V++ L + ET+ ++ E           L K     K+
Sbjct: 3629 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3688

Query: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
             ++ + +    +++       + L++ V      Y  +   +T++ ++++  +  S++  
Sbjct: 3689 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3748

Query: 1578 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1637
            +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G  
Sbjct: 3749 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3808

Query: 1638 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1696
            + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W+ 
Sbjct: 3809 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3868

Query: 1697 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748
            +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G  
Sbjct: 3869 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3928

Query: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1803
                ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++   
Sbjct: 3929 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984

Query: 1804 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1852
               ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  Q 
Sbjct: 3985 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4044

Query: 1853 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1908
             L         +  L  +R  K L++     ++      L+  + D +  +  L +P  D
Sbjct: 4045 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104

Query: 1909 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965
               +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +  
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4164

Query: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025
              +    +I  + EE M    +            Y   +  V   +      L +     
Sbjct: 4165 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4211

Query: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2084
             D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L   
Sbjct: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4271

Query: 2085 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2144
            W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +  
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4330

Query: 2145 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2201
            L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++   
Sbjct: 4331 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4390

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2259
            RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     +   
Sbjct: 4391 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4449

Query: 2260 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++E 
Sbjct: 4450 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4506

Query: 2319 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2372
             +    +    L+D        + WL+     L + ++P+       F + E ++    V
Sbjct: 4507 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559

Query: 2373 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2429
             + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R        
Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4611

Query: 2430 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2489
                                              SL         F+ AW++L +WL   
Sbjct: 4612 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4637

Query: 2490 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2549
            ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +    
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697

Query: 2550 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2609
            + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +  
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757

Query: 2610 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2669
               +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++  
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4816

Query: 2670 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2726
            W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R L 
Sbjct: 4817 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4876

Query: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2786
            D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  ++
Sbjct: 4877 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4926

Query: 2787 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2844
             E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+  
Sbjct: 4927 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 4986

Query: 2845 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2887
               H+ F  E+  K+P +    +T +            I + ++   G ++     LY  
Sbjct: 4987 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5046

Query: 2888 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5047 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092



 Score =  316 bits (809), Expect = 3e-85
 Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)

Query: 341  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898

Query: 401  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958

Query: 451  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077

Query: 566  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131

Query: 621  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 680
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +  L +  
Sbjct: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2188

Query: 681  VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 735
              +  T + T+ Q L    + ++P     +  Q   +S     E +K L+V    LHS +
Sbjct: 2189 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2241

Query: 736  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278

Query: 795  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330

Query: 855  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389

Query: 902  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447

Query: 959  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507

Query: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687

Query: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745

Query: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798

Query: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874

Query: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087

Query: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143

Query: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196

Query: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256

Query: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316

Query: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373

Query: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417

Query: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474

Query: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534

Query: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594

Query: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765

Query: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019

Query: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079

Query: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135

Query: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191

Query: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233

Query: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292

Query: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351

Query: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 403  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432

Query: 455  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492

Query: 514  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552

Query: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611

Query: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654

Query: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696

Query: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795

Query: 866  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855

Query: 924  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912

Query: 984  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972

Query: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024

Query: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084

Query: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144

Query: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196

Query: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256

Query: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316

Query: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373

Query: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432

Query: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492

Query: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552

Query: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672

Query: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732

Query: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792

Query: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851

Query: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911

Query: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967

Query: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027

Query: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074

Query: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131

Query: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188

Query: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248

Query: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303

Query: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356

Query: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384

Query: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435

Query: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494

Query: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554

Query: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614

Query: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668

Query: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728

Query: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782

Query: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827

Query: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887

Query: 2980 ALRGEI 2985
              R E+
Sbjct: 4888 EKRAEL 4893



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 345  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136

Query: 405  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194

Query: 463  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248

Query: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301

Query: 575  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347

Query: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397

Query: 691  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457

Query: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513

Query: 806  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573

Query: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633

Query: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691

Query: 981  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751

Query: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811

Query: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871

Query: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930

Query: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989

Query: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166

Query: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223

Query: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283

Query: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343

Query: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403

Query: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463

Query: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515

Query: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569

Query: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626

Query: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683

Query: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742

Query: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802

Query: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862

Query: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922

Query: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981

Query: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041

Query: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092

Query: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152

Query: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584

Query: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635

Query: 2928 KIDETLERLQELQEATDELDLKLRQ 2952
            + +++L+   E+    D++  +L Q
Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660



 Score =  226 bits (576), Expect = 3e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416

Query: 452  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470

Query: 510  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530

Query: 566  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590

Query: 612  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650

Query: 646  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710

Query: 702  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770

Query: 748  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826

Query: 807  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886

Query: 866  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946

Query: 925  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004

Query: 985  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064

Query: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123

Query: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182

Query: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242

Query: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302

Query: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362

Query: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422

Query: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478

Query: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598

Query: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658

Query: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718

Query: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778

Query: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837

Query: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896

Query: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954

Query: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004

Query: 1934 EGLSEDGAAMAVEPTQIQ 1951
            + +++     A +P+ +Q
Sbjct: 5005 DKVTKTYKRRAADPSSLQ 5022



 Score =  220 bits (560), Expect = 2e-56
 Identities = 114/240 (47%), Positives = 158/240 (65%), Gaps = 7/240 (2%)

Query: 4   WEEVEDCY--EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQK 61
           +E+V + Y  ER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  
Sbjct: 22  YEDVLERYKDERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDT 80

Query: 62  LPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVK 121
           LP+EKG  R H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ 
Sbjct: 81  LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 140

Query: 122 NVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLF 181
           ++  ++    +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL 
Sbjct: 141 DI--HVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198

Query: 182 DWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
           D N+V   QS    LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 199 DMNTVAV-QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256



 Score =  205 bits (521), Expect = 8e-52
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 268  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525

Query: 327  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572

Query: 387  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629

Query: 447  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687

Query: 505  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747

Query: 565  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807

Query: 605  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867

Query: 659  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924

Query: 710  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984

Query: 754  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043

Query: 803  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277

Query: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337

Query: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397

Query: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457

Query: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577

Query: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637

Query: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686

Query: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746

Query: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805

Query: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865

Query: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925

Query: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985

Query: 1720 LKAE 1723
            L AE
Sbjct: 4986 LIAE 4989



 Score =  178 bits (452), Expect = 8e-44
 Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)

Query: 456  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229

Query: 508  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289

Query: 558  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347

Query: 617  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401

Query: 677  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454

Query: 737  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504

Query: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547

Query: 857  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594

Query: 917  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639

Query: 975  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699

Query: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759

Query: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819

Query: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879

Query: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939

Query: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999

Query: 1289 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1316
            L+ T+ + G                               +I + LD +    E+L +  
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2059

Query: 1317 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1364
             +   +++I   TLT    + + ++E L+   +    L E+             + +  +
Sbjct: 2060 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2116

Query: 1365 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1417
            LEQ I   Q +  +++  +++ +   D   A+ +  K+   +A+  + + K +  L    
Sbjct: 2117 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2176

Query: 1418 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
               T  E+     +K     E   + L+++DV  K + ++S             Q +QES
Sbjct: 2177 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2223

Query: 1475 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1532
                 E K HL  L +  K +    + S     +    +LS+   E+E  IK  ++ V  
Sbjct: 2224 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2283

Query: 1533 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1577
             Q +               KE  ++V  ++  +   +LG  + + K+  EK    + +++
Sbjct: 2284 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2343

Query: 1578 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1634
            K  N    L   ++A        +AV+   + L+ E   G AT  E       L SI + 
Sbjct: 2344 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2400

Query: 1635 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694
               +         L++DK++ LN+    +    EE   ++   QK  +T        TKW
Sbjct: 2401 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2453

Query: 1695 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1746
              Q      ++E  K Q +++  K  +AEL     KV   +D+   L+        A R 
Sbjct: 2454 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2509

Query: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1806
                  ++ +  ELN     I  + K  ++S  L + +   + +++ L  +E E+   V 
Sbjct: 2510 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2564

Query: 1807 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1852
            L     + +M       V+ LLQ               G  +  R  ++     I +K+Q
Sbjct: 2565 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2623

Query: 1853 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
            L  +  K ++L    S R     +A+  S Q+    R   D L  LD+  K  +SL    
Sbjct: 2624 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2681

Query: 1908 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1963
                + +     QK K+E+   ++Q   A+ L ED +A+  E   + +LS   R++E   
Sbjct: 2682 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2738

Query: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2020
              F+ +     + V+            L+ +   S    +++   QA L+    EQ  + 
Sbjct: 2739 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2787

Query: 2021 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079
            P     D  E L K     K+   +L   S   +   ++    L      E+  LQ  L+
Sbjct: 2788 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2844

Query: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2136
             +   W+  NK  K+R+ +   S+EK  ++   ++    W+ + +  L + +    P   
Sbjct: 2845 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2904

Query: 2137 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2196
            E++  K  LK LQ  + Q   +V  LN T   ++    + D  ++ ++  SL  +   V 
Sbjct: 2905 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 2961

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2239
            +QL  +K  LE       EFQ    E    L+ A       D++ S          +  +
Sbjct: 2962 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3021

Query: 2240 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2296
                Q LK +++  K L ++L +     K  ++    VL+      +E   L  ++    
Sbjct: 3022 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3077

Query: 2297 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2349
               +T LQ I       R +  +  E + ++  +  + +  E L++Q   +  +L  +  
Sbjct: 3078 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3137

Query: 2350 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2386
             +   +  N+     +   E +                        QA++  VE  + + 
Sbjct: 3138 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3197

Query: 2387 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2426
            +  Y +      + +K E+       +  E + +N+ L           + L+ KQ D  
Sbjct: 3198 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3257

Query: 2427 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2481
             L  GL    A  T T  L      V  +   ++K     +  L+   L    F  A   
Sbjct: 3258 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3317

Query: 2482 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2541
            L  W+   ++++ +Q+    + + +   I +QK   + L+ R+  +E +    + +   T
Sbjct: 3318 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3376

Query: 2542 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2601
            +    +  I  ++  + ++W+ +    + R +QL  +   + Q+ E  E   + L     
Sbjct: 3377 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3436

Query: 2602 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2661
            +L + +        ++++I + K L  D+     ++  A  +   L    S +D   V  
Sbjct: 3437 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3496

Query: 2662 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2721
              +     +  I ++   R   L++     + F  D  + + WL E            + 
Sbjct: 3497 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3547

Query: 2722 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2778
             +L       + L KQ  +L+   E       N+D+   N  ++L+   G D+ +++Q +
Sbjct: 3548 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3606

Query: 2779 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2837
            L+ +  ++ ++ K S ++   LE +    +RLH + +EL  WL   + E LS +  +   
Sbjct: 3607 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3666

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2894
              A Q Q    +  K+E K  + ++ S  E     L   P    EGLEK+  E       
Sbjct: 3667 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3720

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2952
            ER + V+  + ++ EE+    +   L S  + +  D  L  + E ++    L D++L Q
Sbjct: 3721 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 608  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666

Query: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 667  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726

Query: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 727  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  325 bits (832), Expect = 7e-88
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 342  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 1864 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 1912

Query: 402  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 1913 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 1971

Query: 460  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 1972 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2031

Query: 516  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 2032 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2089

Query: 555  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 2090 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2149

Query: 607  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 2150 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2205

Query: 667  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726
            Q +  +  +LTQ   +E                                           
Sbjct: 2206 QKLEESSNNLTQFQTVEA------------------------------------------ 2223

Query: 727  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 2224 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2279

Query: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 2280 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2339

Query: 846  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 2340 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2398

Query: 902  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 2399 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2454

Query: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2514

Query: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2574

Query: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 2575 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2623

Query: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 2624 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 2683

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 2684 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 2743

Query: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 2744 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 2803

Query: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 2804 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 2860

Query: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 2861 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 2911

Query: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 2912 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 2971

Query: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 2972 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3031

Query: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 3032 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3091

Query: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 3092 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3151

Query: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 3152 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3211

Query: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 3212 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3269

Query: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 3270 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3329

Query: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 3330 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3389

Query: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 3390 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3449

Query: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 3450 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3505

Query: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 3506 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3560

Query: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3619

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 3620 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 3676

Query: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 3677 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 3736

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 3737 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 3796

Query: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 3797 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 3852

Query: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 3853 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 3908

Query: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 3909 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 3952

Query: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 3953 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 3990

Query: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 3991 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4049

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 4050 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4109

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 4110 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4169

Query: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 4170 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4223

Query: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 4224 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4282

Query: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 4283 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4342

Query: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 4343 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4383

Query: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 4384 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4441

Query: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 4442 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4501

Query: 3028 QVAVEDRVRQLHEAH 3042
            Q  +E  +RQ  E H
Sbjct: 4502 QTRLEAALRQAEEFH 4516



 Score =  325 bits (832), Expect = 7e-88
 Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)

Query: 334  LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 388
            + E    L + Q A EE   ++ WL  ++   T   Q     D E VK Q   ++ +  +
Sbjct: 2093 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2152

Query: 389  LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 444
            L  +   V  + +L  KL  T  L E+ +T      ++ +  ++S+W+ L   ++++Q  
Sbjct: 2153 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2207

Query: 445  LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 502
            L     +L   +  E  L  WL + E     +   PL  D   L  Q QQ ++L ++   
Sbjct: 2208 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2265

Query: 503  EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 560
             + +   LT     +    G+  +    ++EQL  +  +W ++     DR   +   ++K
Sbjct: 2266 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2325

Query: 561  WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 615
                T+ Q L  +   +  D  NK+ +     T     N+ L + QK+   K +++++K+
Sbjct: 2326 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2379

Query: 616  SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 673
             +    +L +DL + +K + +  +    L+   + + ++ QK E     +  A  ++   
Sbjct: 2380 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2439

Query: 674  ----------------------PSLTQTTVMETVT-------------------TVTTRE 692
                                  P   +  V+E++                    T+   E
Sbjct: 2440 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2499

Query: 693  QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 735
             +L+K    E      Q               K+R+  +   + K L     +  L  WI
Sbjct: 2500 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2559

Query: 736  TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 788
             + +  L+  +F +   EG  S  K K  ++++E  + F  ++  + +A +L+       
Sbjct: 2560 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2617

Query: 789  EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
            E + +E  +    +   +EQL+S+  +FC L +    + E+Q        QLQ  ++   
Sbjct: 2618 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 2674

Query: 848  TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 888
              ++         +L +  T      A+K Q+ + K     L          S +  Q+E
Sbjct: 2675 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 2734

Query: 889  RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 946
             +  +   L ++  +   FL+        HF+    ++ ++  E     D++ P+ R  E
Sbjct: 2735 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 2793

Query: 947  TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1006
            T+   +  ++    KL     S            +   +  + +E    L  +   ++ +
Sbjct: 2794 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 2846

Query: 1007 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
            SK+    + R  Q+  E++EG  K+L     E   KL+E    L+K + H ++       
Sbjct: 2847 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 2894

Query: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1124
                   + P   ++E + +QL   ++   + I+ +Q     VN  GQ  I++ A+    
Sbjct: 2895 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 2947

Query: 1125 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1184
              LE +L ++N +W  + ++V  R   L+  L      Q  L  +  WM   EE    + 
Sbjct: 2948 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3007

Query: 1185 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1244
                    ++  ++E K  +     +++ V+++      +   A P  +  + K+L  L 
Sbjct: 3008 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3067

Query: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
            + ++ L  +   + + LE +     +    LE  N+WL  +E +L   E I   A ++ E
Sbjct: 3068 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3127

Query: 1305 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1356
             +   + L    +D  N  + L Q ++ G  +  L + E +        F+  W  E+ E
Sbjct: 3128 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184

Query: 1357 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1413
            ++  R +LL+Q++ +A+   E  + L+       DK     + D        Q+++   +
Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3244

Query: 1414 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1467
            Q D+   + ++++   +  G E  ++    ++ + Q KL+ +  +++   K +       
Sbjct: 3245 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3302

Query: 1468 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
            EQ LQ ++ +          LD+V++ L + ET+ ++ E           L K     K+
Sbjct: 3303 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3362

Query: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
             ++ + +    +++       + L++ V      Y  +   +T++ ++++  +  S++  
Sbjct: 3363 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3422

Query: 1578 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1637
            +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G  
Sbjct: 3423 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3482

Query: 1638 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1696
            + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W+ 
Sbjct: 3483 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3542

Query: 1697 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748
            +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G  
Sbjct: 3543 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3602

Query: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1803
                ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++   
Sbjct: 3603 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3658

Query: 1804 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1852
               ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  Q 
Sbjct: 3659 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 3718

Query: 1853 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1908
             L         +  L  +R  K L++     ++      L+  + D +  +  L +P  D
Sbjct: 3719 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778

Query: 1909 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965
               +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +  
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 3838

Query: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025
              +    +I  + EE M    +            Y   +  V   +      L +     
Sbjct: 3839 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 3885

Query: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2084
             D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L   
Sbjct: 3886 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 3945

Query: 2085 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2144
            W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +  
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4004

Query: 2145 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2201
            L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++   
Sbjct: 4005 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4064

Query: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2259
            RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     +   
Sbjct: 4065 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4123

Query: 2260 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
               ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++E 
Sbjct: 4124 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4180

Query: 2319 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2372
             +    +    L+D        + WL+     L + ++P+       F + E ++    V
Sbjct: 4181 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233

Query: 2373 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2429
             + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R        
Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4285

Query: 2430 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2489
                                              SL         F+ AW++L +WL   
Sbjct: 4286 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4311

Query: 2490 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2549
            ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +    
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371

Query: 2550 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2609
            + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +  
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431

Query: 2610 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2669
               +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++  
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4490

Query: 2670 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2726
            W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R L 
Sbjct: 4491 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4550

Query: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2786
            D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  ++
Sbjct: 4551 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4600

Query: 2787 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2844
             E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+  
Sbjct: 4601 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 4660

Query: 2845 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2887
               H+ F  E+  K+P +    +T +            I + ++   G ++     LY  
Sbjct: 4661 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 4720

Query: 2888 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
              +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 4721 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 4766



 Score =  316 bits (809), Expect = 3e-85
 Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)

Query: 341  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 1513 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1572

Query: 401  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 1573 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1632

Query: 451  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 1633 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 1692

Query: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 1693 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 1751

Query: 566  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 1752 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 1805

Query: 621  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 680
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +  L +  
Sbjct: 1806 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 1862

Query: 681  VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 735
              +  T + T+ Q L    + ++P     +  Q   +S     E +K L+V    LHS +
Sbjct: 1863 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 1915

Query: 736  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 1916 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 1952

Query: 795  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 1953 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2004

Query: 855  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 2005 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2063

Query: 902  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 2064 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2121

Query: 959  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 2122 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2181

Query: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2241

Query: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 2242 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2301

Query: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 2302 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2361

Query: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 2362 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2419

Query: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 2420 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2472

Query: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 2473 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2516

Query: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 2517 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2548

Query: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 2549 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2601

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 2602 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2649

Query: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 2650 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 2705

Query: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 2706 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 2761

Query: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 2762 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 2817

Query: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 2818 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 2870

Query: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 2871 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 2930

Query: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 2931 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990

Query: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3047

Query: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 3048 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3091

Query: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 3092 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3148

Query: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 3149 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3208

Query: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 3209 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3268

Query: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 3269 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3328

Query: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 3329 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3386

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 3387 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3439

Query: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 3440 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3499

Query: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 3500 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3545

Query: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 3546 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3588

Query: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 3589 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3636

Query: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 3637 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 3693

Query: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 3694 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 3753

Query: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 3754 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 3809

Query: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 3810 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 3865

Query: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 3866 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 3907

Query: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 3908 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 3966

Query: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 3967 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4025

Query: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 4026 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4074



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 403  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 2047 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2106

Query: 455  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 2107 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2166

Query: 514  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 2167 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2226

Query: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 2227 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2285

Query: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 2286 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2328

Query: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 2329 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2370

Query: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 2371 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2410

Query: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 2411 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2469

Query: 866  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 2470 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2529

Query: 924  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 2530 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2586

Query: 984  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 2587 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2646

Query: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 2647 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 2698

Query: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 2699 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 2758

Query: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 2759 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 2818

Query: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 2819 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 2870

Query: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 2871 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 2930

Query: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 2931 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990

Query: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3047

Query: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 3048 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3106

Query: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 3107 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3166

Query: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 3167 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3226

Query: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 3227 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3286

Query: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346

Query: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 3347 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3406

Query: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 3407 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3466

Query: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 3467 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3525

Query: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 3526 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3585

Query: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 3586 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3641

Query: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 3642 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 3701

Query: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 3702 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 3748

Query: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 3749 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 3805

Query: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 3806 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 3862

Query: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 3863 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 3922

Query: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 3923 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 3977

Query: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 3978 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4030

Query: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 4031 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4058

Query: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 4059 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4109

Query: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 4110 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4168

Query: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 4169 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4228

Query: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 4229 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4288

Query: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 4289 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4342

Query: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 4343 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4402

Query: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 4403 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4456

Query: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 4457 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4501

Query: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 4502 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4561

Query: 2980 ALRGEI 2985
              R E+
Sbjct: 4562 EKRAEL 4567



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 345  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 1751 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 1810

Query: 405  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 1811 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 1868

Query: 463  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 1869 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 1922

Query: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 1923 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 1975

Query: 575  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2021

Query: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 2022 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2071

Query: 691  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 2072 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2131

Query: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 2132 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2187

Query: 806  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 2188 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2247

Query: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 2248 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2307

Query: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 2308 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2365

Query: 981  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 2366 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2425

Query: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 2426 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2485

Query: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 2486 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2545

Query: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 2546 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2604

Query: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 2605 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2663

Query: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 2664 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 2722

Query: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 2723 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 2780

Query: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 2781 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 2840

Query: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 2841 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 2897

Query: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 2898 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 2957

Query: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 2958 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3017

Query: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 3018 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3077

Query: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 3078 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3137

Query: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 3138 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3189

Query: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 3190 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3243

Query: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 3244 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300

Query: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 3301 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3357

Query: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 3358 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3416

Query: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 3417 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3476

Query: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 3477 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3536

Query: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 3537 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3596

Query: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 3597 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655

Query: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 3656 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 3715

Query: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 3716 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 3766

Query: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 3767 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 3826

Query: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 3827 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 3851

Query: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 3852 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 3905

Query: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 3906 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 3965

Query: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 3966 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4025

Query: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 4026 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4085

Query: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 4086 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4139

Query: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 4140 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4198

Query: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 4199 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4258

Query: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 4259 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4309

Query: 2928 KIDETLERLQELQEATDELDLKLRQ 2952
            + +++L+   E+    D++  +L Q
Sbjct: 4310 ESEKSLDSELEIANDPDKIKTQLAQ 4334



 Score =  226 bits (576), Expect = 3e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 2973 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3032

Query: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 3033 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3090

Query: 452  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 3091 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3144

Query: 510  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 3145 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3204

Query: 566  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 3205 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3264

Query: 612  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 3265 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3324

Query: 646  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 3325 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3384

Query: 702  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 3385 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3444

Query: 748  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 3445 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3500

Query: 807  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 3501 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3560

Query: 866  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3620

Query: 925  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 3621 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 3678

Query: 985  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 3679 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738

Query: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 3797

Query: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 3798 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 3856

Query: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 3857 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 3916

Query: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 3917 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 3976

Query: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 3977 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4036

Query: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 4037 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4096

Query: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 4097 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4152

Query: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 4153 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4212

Query: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 4213 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4272

Query: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 4273 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4332

Query: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 4333 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4392

Query: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 4393 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4452

Query: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 4453 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511

Query: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 4512 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4570

Query: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 4571 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4628

Query: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 4629 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 4678

Query: 1934 EGLSEDGAAMAVEPTQIQ 1951
            + +++     A +P+ +Q
Sbjct: 4679 DKVTKTYKRRAADPSSLQ 4696



 Score =  205 bits (521), Expect = 8e-52
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 268  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 3140 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3199

Query: 327  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 3200 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3246

Query: 387  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 3247 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3303

Query: 447  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 3304 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3361

Query: 505  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 3362 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3421

Query: 565  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 3422 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3481

Query: 605  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 3482 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3541

Query: 659  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 3542 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3598

Query: 710  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 3599 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3658

Query: 754  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 3659 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717

Query: 803  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 3718 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 3777

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 3778 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 3837

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 3838 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 3891

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 3892 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 3951

Query: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 3952 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4011

Query: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 4012 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4071

Query: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 4072 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4131

Query: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 4132 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4191

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251

Query: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4311

Query: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 4312 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4360

Query: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 4361 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4420

Query: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 4421 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4479

Query: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 4480 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4539

Query: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 4540 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4599

Query: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4659

Query: 1720 LKAE 1723
            L AE
Sbjct: 4660 LIAE 4663



 Score =  178 bits (452), Expect = 8e-44
 Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)

Query: 456  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 844  KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 903

Query: 508  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 904  HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 963

Query: 558  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 964  KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021

Query: 617  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 1022 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075

Query: 677  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 1076 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1128

Query: 737  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 1129 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1178

Query: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 1179 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1221

Query: 857  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 1222 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1268

Query: 917  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 1269 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1313

Query: 975  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 1314 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1373

Query: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1374 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1433

Query: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1434 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1493

Query: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1494 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1553

Query: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1554 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1613

Query: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1614 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1673

Query: 1289 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1316
            L+ T+ + G                               +I + LD +    E+L +  
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 1733

Query: 1317 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1364
             +   +++I   TLT    + + ++E L+   +    L E+             + +  +
Sbjct: 1734 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 1790

Query: 1365 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1417
            LEQ I   Q +  +++  +++ +   D   A+ +  K+   +A+  + + K +  L    
Sbjct: 1791 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 1850

Query: 1418 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1474
               T  E+     +K     E   + L+++DV  K + ++S             Q +QES
Sbjct: 1851 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 1897

Query: 1475 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1532
                 E K HL  L +  K +    + S     +    +LS+   E+E  IK  ++ V  
Sbjct: 1898 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 1957

Query: 1533 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1577
             Q +               KE  ++V  ++  +   +LG  + + K+  EK    + +++
Sbjct: 1958 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2017

Query: 1578 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1634
            K  N    L   ++A        +AV+   + L+ E   G AT  E       L SI + 
Sbjct: 2018 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2074

Query: 1635 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694
               +         L++DK++ LN+    +    EE   ++   QK  +T        TKW
Sbjct: 2075 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2127

Query: 1695 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1746
              Q      ++E  K Q +++  K  +AEL     KV   +D+   L+        A R 
Sbjct: 2128 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2183

Query: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1806
                  ++ +  ELN     I  + K  ++S  L + +   + +++ L  +E E+   V 
Sbjct: 2184 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2238

Query: 1807 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1852
            L     + +M       V+ LLQ               G  +  R  ++     I +K+Q
Sbjct: 2239 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2297

Query: 1853 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
            L  +  K ++L    S R     +A+  S Q+    R   D L  LD+  K  +SL    
Sbjct: 2298 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2355

Query: 1908 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1963
                + +     QK K+E+   ++Q   A+ L ED +A+  E   + +LS   R++E   
Sbjct: 2356 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2412

Query: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2020
              F+ +     + V+            L+ +   S    +++   QA L+    EQ  + 
Sbjct: 2413 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2461

Query: 2021 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079
            P     D  E L K     K+   +L   S   +   ++    L      E+  LQ  L+
Sbjct: 2462 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2518

Query: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2136
             +   W+  NK  K+R+ +   S+EK  ++   ++    W+ + +  L + +    P   
Sbjct: 2519 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2578

Query: 2137 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2196
            E++  K  LK LQ  + Q   +V  LN T   ++    + D  ++ ++  SL  +   V 
Sbjct: 2579 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 2635

Query: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2239
            +QL  +K  LE       EFQ    E    L+ A       D++ S          +  +
Sbjct: 2636 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 2695

Query: 2240 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2296
                Q LK +++  K L ++L +     K  ++    VL+      +E   L  ++    
Sbjct: 2696 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 2751

Query: 2297 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2349
               +T LQ I       R +  +  E + ++  +  + +  E L++Q   +  +L  +  
Sbjct: 2752 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 2811

Query: 2350 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2386
             +   +  N+     +   E +                        QA++  VE  + + 
Sbjct: 2812 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 2871

Query: 2387 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2426
            +  Y +      + +K E+       +  E + +N+ L           + L+ KQ D  
Sbjct: 2872 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 2931

Query: 2427 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2481
             L  GL    A  T T  L      V  +   ++K     +  L+   L    F  A   
Sbjct: 2932 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 2991

Query: 2482 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2541
            L  W+   ++++ +Q+    + + +   I +QK   + L+ R+  +E +    + +   T
Sbjct: 2992 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3050

Query: 2542 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2601
            +    +  I  ++  + ++W+ +    + R +QL  +   + Q+ E  E   + L     
Sbjct: 3051 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3110

Query: 2602 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2661
            +L + +        ++++I + K L  D+     ++  A  +   L    S +D   V  
Sbjct: 3111 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3170

Query: 2662 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2721
              +     +  I ++   R   L++     + F  D  + + WL E            + 
Sbjct: 3171 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3221

Query: 2722 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2778
             +L       + L KQ  +L+   E       N+D+   N  ++L+   G D+ +++Q +
Sbjct: 3222 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3280

Query: 2779 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2837
            L+ +  ++ ++ K S ++   LE +    +RLH + +EL  WL   + E LS +  +   
Sbjct: 3281 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3340

Query: 2838 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2894
              A Q Q    +  K+E K  + ++ S  E     L   P    EGLEK+  E       
Sbjct: 3341 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3394

Query: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2952
            ER + V+  + ++ EE+    +   L S  + +  D  L  + E ++    L D++L Q
Sbjct: 3395 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3449



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 282  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340

Query: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 341  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 400

Query: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 401  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score =  318 bits (815), Expect = 6e-86
 Identities = 605/3116 (19%), Positives = 1210/3116 (38%), Gaps = 511/3116 (16%)

Query: 12   EREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST- 69
            E+E VQK+TFTKW+N+  +K     + ++LF D++DG +LL LLE L+GQKLP E+G   
Sbjct: 24   EQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRM 83

Query: 70   -RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNI- 127
             R+HA+ N+  AL+ L+   + LVNI STDI DG   + LGL+W IIL++Q++ +  N+ 
Sbjct: 84   KRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLP 143

Query: 128  ----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNVINF 159
                                        +    Q N++K LL WV+ +      + V +F
Sbjct: 144  QLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDF 203

Query: 160  TTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVD 219
              SW  G+A +++IH+ RP+L D  +V   +S  + LE AF IA  +LGI +LLDPEDVD
Sbjct: 204  GKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPEDVD 262

Query: 220  TTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQLHH 270
               PD+KSI+ Y+    +  P     S +  ++ E+LP  P          +E+      
Sbjct: 263  VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKE 322

Query: 271  QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL-------E 323
               + +Q    L +     S+ + +++S+ + +  Y              H        +
Sbjct: 323  MKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQ 382

Query: 324  APEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDVEVV 375
            A   +S+    S L +  + LD+   A L  + +WL  AE  L+ +  +          +
Sbjct: 383  ALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTI 442

Query: 376  KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435
            + +   H+  + +  AH+     I +  ++ +    +  D+  ++ E+ + ++S  E L 
Sbjct: 443  QRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE-LH 499

Query: 436  VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
            +  ME     +R+L  L   + K L  W+ K   R             E +++ +Q +  
Sbjct: 500  LMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQNYVS 545

Query: 496  LQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTED 549
              E+    EQ +V    L     +  ++ G    A  E  +K + +   +W N+      
Sbjct: 546  FIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVEVRS 603

Query: 550  RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTGFKD 592
               +L++++  W R         AWL + E  +N+                  HT     
Sbjct: 604  VRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDA 663

Query: 593  QNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARC-- 650
             N ++ +  ++  +  DL   KQ +  L    ++L   +K  +   + +     +  C  
Sbjct: 664  GNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVV 718

Query: 651  ---------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQE 701
                        L + LE S   +   +   +    +  VM+    + T+   L+     
Sbjct: 719  TLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES- 777

Query: 702  ELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE 761
                P  + K      S+++++L   + E +S +      L  P   + ++  +F D   
Sbjct: 778  ----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLG 832

Query: 762  KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSE 821
            K+N I          + +    + AL +Q   E +       A ++   + +   +  S+
Sbjct: 833  KINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEKGSQ 877

Query: 822  RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLS 881
             +      +N++  ++Q +   Q+      +  +   T      +++  ++ K    +  
Sbjct: 878  SVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK----KFE 933

Query: 882  GLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940
              + ++E+ L+I    L+EKG     L      F+   ++V   + A  K    + D LP
Sbjct: 934  ESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTDILP 990

Query: 941  PMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQSSL 989
                Q    A+R     W   Q E    +  L + D E       +E+   EL   ++ L
Sbjct: 991  EQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-ETKL 1048

Query: 990  QEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRWKKL 1032
              Q+     +       S K P  +  K     EE+                     K+L
Sbjct: 1049 MPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKEL 1108

Query: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILKKQL 1088
             + +    +KL E  +K +   +       W++  +  LK    E        E+ K+ +
Sbjct: 1109 RAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-KRAV 1167

Query: 1089 KQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQ 1144
            ++ R  V+     +  ++  L  + E   + + + + +  ++L +  K L T    + + 
Sbjct: 1168 EEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKM 1227

Query: 1145 V------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
            +         KE +K  LE+ +S  K++ E  E +   E  +                  
Sbjct: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF------------------ 1269

Query: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL-------- 1243
            E ++     QQK  ++      V   IAQA       P    E L+K   TL        
Sbjct: 1270 EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRE 1329

Query: 1244 -------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKLKTT 1292
                    T  +W     N +   + L +  +     LS+  LE  +  L + +   K T
Sbjct: 1330 RQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRT 1389

Query: 1293 ENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINEELE 1345
            E+I   AE    E SE+    +N   L + ++    Q++ L  TL +     E++  + +
Sbjct: 1390 ESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWD 1449

Query: 1346 TFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 1405
             F S +  L      ++K L     S+   +  +  I+ ++  I+ +L++ +  + +A  
Sbjct: 1450 HFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQS 1509

Query: 1406 MPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRL 1460
              Q     E+ +I++ LT      EE+++H Q  E    +L  +   QK  +++    ++
Sbjct: 1510 FAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR---KI 1564

Query: 1461 FQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE 1520
             Q  + FE +L         +K+   A ET  V QE         ++L ++L  + S + 
Sbjct: 1565 QQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSSAIT 1610

Query: 1521 MVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEM 1580
                + R++V      N     +   AL+  Y ++  +  ER+  LE  L   +++ KE+
Sbjct: 1611 AFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1664

Query: 1581 NVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 1639
            +    WL   + + +     +      ++ E+   +A Q E+  Q      + ++ E+L 
Sbjct: 1665 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLF 1724

Query: 1640 TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1698
            +V  K +  +++  L  L+  W  +     + +N L       + FD+ +   + WI   
Sbjct: 1725 SVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF 1784

Query: 1699 DTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NLMAN 1744
             + L  + +      +  L R K   AE+   + ++ S +   A           +L+  
Sbjct: 1785 LSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844

Query: 1745 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--AEIQ 1802
            + + C +L E     +  R  A+SH          L E  Q ++ +  +L  L    E  
Sbjct: 1845 KAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTVEAT 1894

Query: 1803 QGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIKQQL 1853
              +N  E D   KD+N+   N   ++      D +        +I    +R   +     
Sbjct: 1895 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1954

Query: 1854 LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRDE-- 1909
            L  +   +++L   ++ +A  ++     ++ Q ++LLK ++DIE++     L EP  +  
Sbjct: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014

Query: 1910 ----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQ--IQLSKRWREIESKF 1963
                R   +++ EL   + EL  ++ +A+ +++   A A E  +   +L   W + +   
Sbjct: 2015 QQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLI 2074

Query: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEIS---YVPSTYLTEITHVSQALLEVEQLLNA 2020
             + +      I  +RE   +       LE +    V  T + +   +  A  + E   N 
Sbjct: 2075 HENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2134

Query: 2021 PDLCAKDFE--------------------------DLFKQEESLKNIKDSLQQSSGRIDI 2054
             +   KD +                          D+    +   ++ + L+++  R+ +
Sbjct: 2135 MNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRV 2194

Query: 2055 IHSKKTAALQSATPVER------VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR 2108
              S     L +   +E        ++ E +S LD    +  ++ K+ +        +   
Sbjct: 2195 SLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEE 2253

Query: 2109 FHYDIKIFNQWLTEAE-----QFLRKTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRT 2161
             H  +    +     E     QF+ +  + +  EHAK    + +  L+D   Q   V + 
Sbjct: 2254 LHSKVNDLKELTKNLETPPDLQFI-EADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKF 2312

Query: 2162 LNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC---KQLSDRKKRLEEQKNILSEFQR 2218
            +N    +I    +K + S+       +N    E C   K++ D +K L+ Q++ +S  Q 
Sbjct: 2313 IN----DITTWFTKVEESL-------MNCAQNETCEALKKVKDIQKELQSQQSNISSTQE 2361

Query: 2219 DLNEFVLWLEEAD----------------------NIASIPLEPGKEQQLKEKLEQV--- 2253
            +LN        A+                      +     L+   E+   E +++    
Sbjct: 2362 NLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEW 2421

Query: 2254 ------------------KLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2295
                              K+L  +L   Q IL  +++  G   + A ++ E Q    +  
Sbjct: 2422 FLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSD--GQSKLDA-VTQEGQTLYAHLS 2478

Query: 2296 KQ--TNLQWIKVSRALPEKQGEIEAQIKDLGQLE---KKLEDLEEQLNHLLLWLSPIRNQ 2350
            KQ  +++Q  ++++A  E Q  ++  +KD   L+    +L   E+Q   L LW+  +  +
Sbjct: 2479 KQIVSSIQ-EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER 2537

Query: 2351 LEIYNQPNQEGPFDVQETEI--------AVQAKQPDVEEILSKGQHLYKE---------- 2392
                N    +     ++ E+         + A +  ++++  +GQ L +E          
Sbjct: 2538 FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRL 2597

Query: 2393 --------KPATQPVKRKLEDLS---SEWKAVNRLLQEL----RAKQPDLAPGLTTIGAS 2437
                    +   +  K KL        E +A+   LQ +    +A Q  LA   +T+G+ 
Sbjct: 2598 CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSK 2657

Query: 2438 PT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD---------WL 2486
             T  + ++ +   ++ K     KL M  ++     AL   N+    +           W 
Sbjct: 2658 DTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQRVIQTQLETLKEVWA 2715

Query: 2487 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE----------QRRPQLEELITAAQN 2536
             ++   + +Q  +   +   N+ + ++    Q +E          Q +P L+E      +
Sbjct: 2716 DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDH 2775

Query: 2537 LKNKTSNQEARTIITDRI---------------------ERIQNQWDEVQEHLQNRRQQL 2575
            L++  S  E  T    R+                     E ++ Q++++    + + +++
Sbjct: 2776 LQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKV 2835

Query: 2576 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQT 2635
             E++KD   +L+A  E    L  A+ +L  W +      A QKK+++ K+L        +
Sbjct: 2836 EEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGAS 2895

Query: 2636 NVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFP 2695
             +     LA ++ ++ +A     +H   + + A W+     V + ++ LE    L+ Q  
Sbjct: 2896 RLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLE---NLVSQMA 2952

Query: 2696 LDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEA 2747
            L  ++F   +A L +A E  + +L+   ++  LLE     +E+++ W   Q  ++A
Sbjct: 2953 LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDA 3008



 Score =  215 bits (547), Expect = 7e-55
 Identities = 376/2031 (18%), Positives = 818/2031 (40%), Gaps = 220/2031 (10%)

Query: 774  FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 824
            ++ L+ +    Q  + Q++++G      ++   ++    QL   W+     +S+ L+   
Sbjct: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791

Query: 825  -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 876
                 W  YQ+      + LQ  +      E W +   T P E   ++  L    +   E
Sbjct: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848

Query: 877  VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 935
            V+  S L+  +     Q + LK+       L ++     + +  + +++ A +++L  + 
Sbjct: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906

Query: 936  FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 992
             D LP    +  +S + +W+   E  +   + ++ +   Y+ + + L + +  +  +  +
Sbjct: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963

Query: 993  QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1048
            Q  + +++ +V ++S +   E  R  +++F E  G     W+ L   + E  Q LE  + 
Sbjct: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022

Query: 1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1108
               + +N++Q LK W    +  LK++   +GD   ++  LK C+ L   I+  +  +  +
Sbjct: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081

Query: 1109 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1168
             + G  +    + + +S + + L+EL   W ++   V   K  LK  L++  S +    +
Sbjct: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141

Query: 1169 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1228
            ++ ++ +A            + + +Q  V+ ++  +++ +++E  ++      N ++ + 
Sbjct: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201

Query: 1229 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
             P   E L   L+ +   +  L   +  + ++ + +   W     Y ++    + + E +
Sbjct: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261

Query: 1289 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1338
                LK   N     +E++  +    +L++     +D+   +  L + L    D      
Sbjct: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321

Query: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1397
            + +++L + +     L +   ++Q  L+  +   +   KSL  ++  +   ++ L     
Sbjct: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380

Query: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457
            +   D + + +  ++++  +        ++ + N   E   R L   D   K++Q+++  
Sbjct: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436

Query: 1458 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1503
            + L      ++ +  +  L + +  L++ +  +          A+E     Q +++ Q  
Sbjct: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496

Query: 1504 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1562
            H   L+++    + ++   +I  G++++++ Q ++  E + ++T L   +  +  +  +R
Sbjct: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554

Query: 1563 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1620
            +  ++  ++  ++ R+    L +WL   ++     S +  +P  L  +   + +   KE 
Sbjct: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612

Query: 1621 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1678
              + +Q  ++ ++    + L +     E  ++ +L+ +   W + + R EE    L    
Sbjct: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672

Query: 1679 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1733
            K  E  ++ +         AD+L  L   +KK  Q   D  + L AE     ++   V S
Sbjct: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723

Query: 1734 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1784
              D    L   +      +    IS LN R       +  + H++   +  I   L E  
Sbjct: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783

Query: 1785 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1834
             F   N ++ + L  +E+++ Q  ++  E+  + + +D +  +        +L Q G+ L
Sbjct: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843

Query: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894
              + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L 
Sbjct: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902

Query: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1942
             IE +LA  P   D    +EI R+L +++E    + + + G++             D  A
Sbjct: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961

Query: 1943 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1997
               E   IQ     L +RWR I    +  RRL         EET  +  +          
Sbjct: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003

Query: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2053
              +L + +     L   E+    P      +    E+L K E   + + + L Q    ++
Sbjct: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057

Query: 2054 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2113
            +I+ +     +         L++ + + + +W+ + K       R    + +   F    
Sbjct: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117

Query: 2114 KIFNQWLTEAEQFLRKTQIPENWE---HAKYKWYLKELQDGIGQRQTVVRTLNATGEEII 2170
                 WLTE +  L+ T I    E    AK K  LK  Q  I      +  + A GE++I
Sbjct: 8118 DSILVWLTEMD--LQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLI 8174

Query: 2171 QQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA 2230
            ++S   DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++
Sbjct: 8175 EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDS 8232

Query: 2231 DNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQD 2289
              ++ +         L        L    L L Q +  + +    P  V S P+  +   
Sbjct: 8233 AALSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 8289

Query: 2290 KLENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2345
             L   L+        +SRALP    E Q + +  ++    L      LE Q+  L     
Sbjct: 8290 DLSRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL----- 8338

Query: 2346 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2405
                      +   +  F +Q+TE  +++K P   E+            + +   + L +
Sbjct: 8339 ---------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGE 8379

Query: 2406 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSS 2464
             SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L M  +
Sbjct: 8380 CSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438

Query: 2465 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2524
            L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + ++ R+
Sbjct: 8439 LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRK 8496

Query: 2525 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2584
              +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L+D+  
Sbjct: 8497 AIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALM 8550

Query: 2585 WLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVD 2638
              +   E    L      ++  K     +D+      +Q    +  Q+  +L + Q  V 
Sbjct: 8551 QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610

Query: 2639 VANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2685
               D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661



 Score =  195 bits (496), Expect = 6e-49
 Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)

Query: 333  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 390
            +L +    L  ++    ++  W+   E+    +  GE    +   K++ H  E ++ +L 
Sbjct: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568

Query: 391  AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
            A +  +  + Q G  L   G  +  E       +    NLL    E LR   +  Q   H
Sbjct: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626

Query: 447  RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 505
              L     + L+ +  W+   ++R    E      D LE    Q+Q   +++ + E   V
Sbjct: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679

Query: 506  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
            ++N           SS       ++ QL+ L + WA+I   +      L+ ++ +W    
Sbjct: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739

Query: 566  EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 623
            E +     W+   +  +        G K++  +L  LQ +    ++ E   +++ +L + 
Sbjct: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796

Query: 624  KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 669
             ++L    +++S      ++ +   ++        ++K+E+          +  + +  +
Sbjct: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856

Query: 670  TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 729
             + +  L + + M   ++ T ++   +K   +       +  R  ++  E+++       
Sbjct: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916

Query: 730  EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 788
            EL H+ +    A  +  E ++F+ +    +L  ++   E+E + +  +L+ A     AL+
Sbjct: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976

Query: 789  EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 825
            +         EG N D                    +  +E L S+  E C+   +   +
Sbjct: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036

Query: 826  LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 862
                + +I  YN L            Q L+Q    A    + WL     T       P  
Sbjct: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096

Query: 863  PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 917
             + + + L+  ++ ++     Q ++  +      + ++  KEK +G   + A   A    
Sbjct: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153

Query: 918  FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 977
            +K   S++  +E  L+ +   +    ++ +   I+ W+  S+T+  + + S   Y++  +
Sbjct: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209

Query: 978  RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1032
            R  E Q LQS L+E    ++     +  + +KA         S+ ++    ++  ++  L
Sbjct: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264

Query: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
            S+   E   +L+  + +  +    I+ L+ WM +    L        D  +L  +  +  
Sbjct: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324

Query: 1093 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1152
             L+S  Q  +  +  +   G+ +     PE    ++ +L+ +   W  +       K  L
Sbjct: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384

Query: 1153 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1211
            +G L K  S Q  + +   WM                 D ++  + E +R   E + K  
Sbjct: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427

Query: 1212 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
               K KLL E V S         +  A        + EL+ L   Y+ +  R        
Sbjct: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487

Query: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
            E++     E    L+    WL + + KL     + G A      L  L+ L  H  +   
Sbjct: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547

Query: 1322 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379
             +  +  T  D     + +  +  LE+    W+         Q  L ++          L
Sbjct: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600

Query: 1380 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1439
             L+++    +D+ L         A +      + QS+  + EI L +MKK ++   A + 
Sbjct: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653

Query: 1440 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1497
             + ++   AQ+ L +  +  R+  +      R Q   + +L+++K     +++    +  
Sbjct: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713

Query: 1498 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1528
            + S  +   + +K+   V ++++ V        +KT                     G +
Sbjct: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773

Query: 1529 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1588
             V+  +    + L + +        EL + V +    LEK L L+++   +   LT+W+A
Sbjct: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833

Query: 1589 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1648
                 L      +       ++++  K+ Q+ +   +  +KS+ E GEAL  ++  ++  
Sbjct: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891

Query: 1649 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1702
            ++DK+  L S++  + S  +E +  L    K  E ++  +  + KW++Q      A  LL
Sbjct: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951

Query: 1703 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1762
            + S  +   Q+    K +  E+     ++++ + +   L+    DH +       ++L  
Sbjct: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004

Query: 1763 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1817
               A     K   ++I         S  Q++ + LE E+Q+ V+ ++     + +   + 
Sbjct: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056

Query: 1818 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1865
             D E + +  L R + ++Q    R   E+ R  + +   +    + ++    KD++    
Sbjct: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116

Query: 1866 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1913
               Q+  +A  ++  W + K    +L   L D +++L ++     E           ++K
Sbjct: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176

Query: 1914 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1973
            +  ++LQ K+  +N +  +   L++                  +E   +  +   LN   
Sbjct: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218

Query: 1974 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2030
            +   R+   + +  +  L+         T   H    ++EV  E+     D L   D E 
Sbjct: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270

Query: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
                 E+LK +  +LQ+    I+ +  +K   ++     ++  ++E  S L+ +W ++  
Sbjct: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330

Query: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2150
            + K    +   SV      +     F + +  AE+     Q P   E  K        Q+
Sbjct: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382

Query: 2151 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2210
             +     +   L A  ++++ +S   DA  +   LG LN R Q + K LSD +  +    
Sbjct: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438

Query: 2211 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2263
            +++ + ++ LN+ +   E+   + ++     + QQ + K+   E + LL +++  +    
Sbjct: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496

Query: 2264 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2315
               Q  LK   NE  G       +  E  EQ+K E   KL++    +  V +    +  E
Sbjct: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556

Query: 2316 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
            +E   K+L   +   ED ++  +    WL     Q +I   P           EI +  +
Sbjct: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594

Query: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2430
              ++   L+K Q++ ++ P  + +   L  L    + +   L E     L  K   L   
Sbjct: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651

Query: 2431 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2487
               I A        V + ++ ++   S +E+ +  + E+ A     ++  T+L   + LS
Sbjct: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711

Query: 2488 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2546
            L D        + G  E ++E+  K++      +  +P ++  L+T    LK +T     
Sbjct: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767

Query: 2547 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2606
                  R+  +++     QEH +   QQL   LK        KEE  +V  +     E  
Sbjct: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815

Query: 2607 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2666
            K       ++Q      K++   L     ++D    LA +  R        ++ ++T   
Sbjct: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870

Query: 2667 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2724
                 +I + V+E E+ + ++      F  ++ + L WL   +AE +  V  D      L
Sbjct: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917

Query: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784
             +  + ++++    +++Q  +     + H   E   K  + L  +D    L+  L  ++ 
Sbjct: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972

Query: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2844
               ++++     ++ L     Q +R +   Q    WL+    EL + A  G D  + ++ 
Sbjct: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031

Query: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2901
               H  F     T++    +  E   +  T  PL    G E L Q+   L  E R+Q ++
Sbjct: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086

Query: 2902 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2961
            R    Q + +    ++      D+Q+  +E +E + + ++       KL +  ++K S  
Sbjct: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135

Query: 2962 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3020
                      ++ L + KAL   +    E +  + + A QL   G   S   LS ++  +
Sbjct: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188

Query: 3021 NTRWKLLQVAVEDRVRQLHEA 3041
              RW  L+   +D+ + L +A
Sbjct: 5189 WQRWTRLRAVAQDQEKILEDA 5209



 Score =  192 bits (489), Expect = 4e-48
 Identities = 415/2214 (18%), Positives = 873/2214 (39%), Gaps = 377/2214 (17%)

Query: 417  ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKM-- 474
            E    ++++ L   ++ L +    ++S L++ L  L++Q  + L D     E    KM  
Sbjct: 6553 EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6611

Query: 475  EEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV--VVDESSGDHATAALEEQ 532
            +++ +    E++++ + +HK   + LE   +   +L   ++   V + +  H T  + + 
Sbjct: 6612 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFH-TELMAQA 6670

Query: 533  LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD 592
              VL        +    R V L+ IL  W  L E+Q   S  L   E ++  +   G  +
Sbjct: 6671 SAVL--------KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV---GLVE 6719

Query: 593  QNE--MLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK----NKSVTQKTEAWLDN 646
            +NE  ++  +     LK+ L + +  + ++    + LL ++        + Q  E WL N
Sbjct: 6720 ENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSN 6779

Query: 647  -------------FARCWD-------NLVQKLEKSTAQIS----QAVTTTQP-------- 674
                           + W        +L+  L+ +  ++     Q+VT  Q         
Sbjct: 6780 TNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL 6839

Query: 675  -------------SLTQTTVMETVTTVTTREQILVKHAQEELP-------------PPPP 708
                         S  +++V+ T   +   +++     + EL              P   
Sbjct: 6840 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 6899

Query: 709  QKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG--NFSDLKEKVNAI 766
            +K  Q+ +D    +     I+E+ SWI+  E V+Q  E  I    G     +  +K    
Sbjct: 6900 EKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGF 6956

Query: 767  EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE--QLNSRWIEFCQLLSERL- 823
            + +   K   +   ++S   +  Q V E   +D    A +   +N  W     L++E++ 
Sbjct: 6957 KIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015

Query: 824  -------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDE 876
                   +W EY+NN+       Q L+    T E  LK Q     +  ++++ LK C+D 
Sbjct: 7016 LLEGLLESWSEYENNV-------QCLKTWFETQEKRLK-QQHRIGDQASVQNALKDCQDL 7067

Query: 877  VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 936
             + +   + ++E+++   +AL +  +    + +  ++      Q ++++     +L+ + 
Sbjct: 7068 EDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQLKILL 7125

Query: 937  DTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 994
             ++      ++     I +++ ++   LS  +L     E ++ ++  LQ LQ  L++Q+ 
Sbjct: 7126 KSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQER 7185

Query: 995  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1054
             L    +   ++ K+    ++    +  +E+  RW  L  ++ E  Q  +  +   ++ +
Sbjct: 7186 SLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYK 7245

Query: 1055 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LKQCRLLVSDIQTIQPSLNSVNE 1110
            ++ +     + + +    E   A  + +I   +    ++ C  L+  + T++ SL  ++E
Sbjct: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHE 7305

Query: 1111 GGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVYARKEALKGGLEKTVSLQKDLS 1167
             G+++K + +   AS ++++   L+    H+C   Q +  ++ +L+ G+    +  K L 
Sbjct: 7306 LGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362

Query: 1168 EMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226
             +  W+ +AEE    +D  + +    +Q+ +EE+K    +       +  L E     + 
Sbjct: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-----LG 7417

Query: 1227 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN-EV 1285
               P+  + +K+ ++ L  ++  + ++   +   L+  +   H+  ++LEK   W+   V
Sbjct: 7418 YRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-FLLQHQ--TFLEKCETWMEFLV 7473

Query: 1286 EFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL--I 1340
            + + K    I G  + + E     +  +  M   +   + I I  Q L + G +D+    
Sbjct: 7474 QTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7533

Query: 1341 NEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTF------------ 1388
            N +L   +++W+ +   A +R+ +++  I+  Q   +    +++ L              
Sbjct: 7534 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV 7593

Query: 1389 -IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-QRVLSQIDV 1446
             I  Q A  + D+V   +     Q+  S + + E   + +   + G EAA Q  L++I  
Sbjct: 7594 PIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQLLLSADSGAEAALQAELAEI-- 7650

Query: 1447 AQKKLQDVSMKFRLFQKPANF--------EQRLQESKMILDEVKMHLPALETKSVEQEVV 1498
             Q+K +  SM+    +K   F        E+ + +S   L   K  L   ++     E +
Sbjct: 7651 -QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS--QSLPDHHEEL 7707

Query: 1499 QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAK 1558
             ++   C  L  ++     ++  +      +      ++   L+ERV  L+  + EL  +
Sbjct: 7708 HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQ 7767

Query: 1559 VTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS--AVEGMPSNLDSEVAWGKA 1616
            ++ R+QQ+ + L       ++   L EWL   + ++++     +E M   L       K 
Sbjct: 7768 LSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KD 7821

Query: 1617 TQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLL 1675
             Q+EI   + +   + ++GE L K     K + +E KL  +N  W  +       +  L 
Sbjct: 7822 YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK 7881

Query: 1676 EYQKHMETFDQNVDHITKWIIQADTLL-----------DESEKKKPQQKE---------- 1714
            E    ++  D+N+  +  W+   ++ L           +E ++K  +Q+E          
Sbjct: 7882 ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHST 7941

Query: 1715 ---DVLKRLKAELND-----IRPKVDSTRDQAANLMANRGDHCRKLVEPQI--------- 1757
                VL   +  L+D        + DS +    NL     + C   +E ++         
Sbjct: 7942 GVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW 8001

Query: 1758 ----------------SELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEI 1801
                            SE    F + S  I T  A   LK+ E F   + + L  LE   
Sbjct: 8002 QKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEELKKFEAFQRQVHECLTQLEL-- 8058

Query: 1802 QQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQRITD----------------- 1840
               +N +     ++   D+  ++K+++    QR DNLQ+R+T                  
Sbjct: 8059 ---INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115

Query: 1841 ---------------------------ERKREEIKIKQQLLQTKHNALKDLRSQRRK--- 1870
                                       + K +++K  QQ +   HN ++ + +Q  +   
Sbjct: 8116 ARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE 8175

Query: 1871 -----KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK-- 1923
                  A  I  +  + +R   ++   ++   KKL  LP P DE  + + + EL+     
Sbjct: 8176 KSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8235

Query: 1924 EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1981
             +L+   R A+ L   +  + +++   Q   S+R             L +   + +  + 
Sbjct: 8236 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8295

Query: 1982 MMVMTEDMPLE-----------------ISYVPSTYLTEITHVSQAL----LEVEQLLN- 2019
               M+  +P E                 +S   S   ++I  + +AL     +++Q  N 
Sbjct: 8296 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI 8355

Query: 2020 -------APDL-------------CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKK 2059
                    P+L             C+   + + + E  LK  ++SL    G ++ +HS +
Sbjct: 8356 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL---PGFVN-LHSTE 8411

Query: 2060 TAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQW 2119
            T   Q+A  ++R             WE +      ++ R  ++++KW++F+ D+     W
Sbjct: 8412 T---QTAGVIDR-------------WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 8455

Query: 2120 LTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2174
            L + E+ L + Q  E          + K  LKELQ  +  R+ ++ ++N    E  Q  S
Sbjct: 8456 LGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVDHRKAIILSINLCSPEFTQADS 8514

Query: 2175 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2234
            K ++  LQ++L  +N RW  VC  L + +  L++       F    +  +L LE  D   
Sbjct: 8515 K-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 8573

Query: 2235 S--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
            +  +P++   + + L++  +Q+  +  EL   Q  +  L +    +LV+A    E  D L
Sbjct: 8574 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA----EGTDCL 8629

Query: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2345
            E K K        +   L     E+   IK+L    +KL D+      L  W S
Sbjct: 8630 EAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKLLDVSSSQQDLSSWSS 8674



 Score =  179 bits (453), Expect = 6e-44
 Identities = 534/2830 (18%), Positives = 1094/2830 (38%), Gaps = 372/2830 (13%)

Query: 382  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 440
            H+ ++++L   Q  +G + Q    ++  G   +  EE  + +++  +  R  CL +    
Sbjct: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311

Query: 441  KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 493
            K +N   V  +L+++++ E     +  W+ +T+E      +E +    +L+ L  +   H
Sbjct: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370

Query: 494  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
            +   E + +EQ +   L    ++  E S   A  AL+ +++   D+  +  +  E     
Sbjct: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426

Query: 554  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612
             Q++  + Q+L ++       L  K D V +  T       E+     KL  L A ++K 
Sbjct: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486

Query: 613  ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 660
                        + +GKL  L Q  +   +N+ S   +  + L+ +    + +++ +EK 
Sbjct: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546

Query: 661  -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 698
                       S +Q+ +     Q  L +           T  ++ +T+V   E++  + 
Sbjct: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606

Query: 699  AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 753
            A+     EEL      + + +   ++  K+ + ++ +L + + +++A L SPE      +
Sbjct: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666

Query: 754  GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811
               S  +  ++ +E  + K +  +  Q A R  + +V  +      A  +++ + +L   
Sbjct: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725

Query: 812  WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 871
             I+ C ++   +  ++Y+     +  +++ L+Q+   A   ++ +P   S    +++Q+ 
Sbjct: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779

Query: 872  ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 915
              ++   ++ G Q QI  L  K + + +K K               +G   LD + +   
Sbjct: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839

Query: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
            +    V      R   L      L P+  +       + +       S   ++ TD  + 
Sbjct: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892

Query: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1035
             Q +   QAL +   +  +   + ST+  +   +   E S    ++  +++  W+ L + 
Sbjct: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950

Query: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1095
            + E  + L E + + +K Q+ +Q++   M  +++ L E  P  G S   + Q+ + + L+
Sbjct: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007

Query: 1096 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
             +I  +Q  +N +     +++ +E   A+P     L++ L  L  +   +  +   +++ 
Sbjct: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067

Query: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
            L+  L   +  Q+    +  +  +A+E      +   T   L  A+   K   +   Q  
Sbjct: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124

Query: 1212 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNYQWLCTRLNGKCKTLE----EVWA 1266
                +L E    V+A +   V  E L  E +  T +      +L GK + L+    E+  
Sbjct: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDE---AEQLAGKLRRLKGSLLELQR 6181

Query: 1267 CWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEV 1305
              H+    ++   +   E +  L  T++ PG  E                     E+ + 
Sbjct: 6182 ALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6240

Query: 1306 LDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWR 1352
            L   ++L+R       +I I    A+T  D G   +++++EL          +    +W 
Sbjct: 6241 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6300

Query: 1353 ELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK 1412
             LH+E   +QKLL+  ++  QE        Q   +  ++ L+     K D     Q+   
Sbjct: 6301 SLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSA 6350

Query: 1413 IQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ 1472
            + S L     + EE+   + G +        I + QK    VS          + E+RL 
Sbjct: 6351 VTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLF 6402

Query: 1473 ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1532
             +  +L E        ET    QE+          L K + E+  E++       Q    
Sbjct: 6403 VATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-P 6445

Query: 1533 KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDM 1592
            +  +N   +++ +  L    + L + V +R  Q+++ L+     + ++ VL   LA    
Sbjct: 6446 ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKY 6505

Query: 1593 ELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKET 1647
             + ++ A   E   +     +   +   KE +   + LK      +V +     L K + 
Sbjct: 6506 IILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQD 6565

Query: 1648 LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 1707
            + ++ + ++ S      S   + L L  +Y++ ++               AD L    EK
Sbjct: 6566 MYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEK 6608

Query: 1708 KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SEL 1760
                QK  ++   K E+  +  K         + M       RK++   +       +EL
Sbjct: 6609 MAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL 6666

Query: 1761 NHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 1813
              + +A+  R    K  + L+        L++   ++ + LE +E+ I   V L EE  N
Sbjct: 6667 MAQASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--N 6721

Query: 1814 KDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1870
            +D   D     + L    +  Q +   + D+ KR  I I    L+++ N L +       
Sbjct: 6722 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6781

Query: 1871 KALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1923
            K  +  H+       W +Y+ ++ DL+  L   + +L    +     +   + +EL+  +
Sbjct: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVR 6836

Query: 1924 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
            + LNA    ++ +    +  +              + S   Q  RL      T+R E   
Sbjct: 6837 DHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSR 6883

Query: 1984 VMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQE 2035
            + ++   L ++ +P+  + E  H  Q        A+ EV   ++  +   +  ED  K  
Sbjct: 6884 IDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 6940

Query: 2036 ESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLD 2082
               K I + LQ+  G +IDI   + T      + LQ S+  VE     +    E L  ++
Sbjct: 6941 IGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMN 7000

Query: 2083 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2142
              W+ +  +  ++    +  +E W  +  +++    W    E+ L+  Q     + A  +
Sbjct: 7001 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQ 7058

Query: 2143 WYLK---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2199
              LK   +L+D I  ++  V  +   G  +IQ   +  +SI+   L  L   W  +   +
Sbjct: 7059 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7118

Query: 2200 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVE 2258
               K  L+   +  S  +   ++   +L EA  +++   L  G  + ++ +++ ++ L +
Sbjct: 7119 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD 7178

Query: 2259 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2318
            +L  ++  L++       +L      P   + L N LK+ N++W      L E+  E   
Sbjct: 7179 DLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQ 7232

Query: 2319 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQP 2377
              K L QL ++ +D  +Q        S ++ Q +  N+  +     D+ + E+A   +  
Sbjct: 7233 SSKALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ-- 7284

Query: 2378 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2437
            D  ++L KG    K+          L +L  + K      Q++ A             AS
Sbjct: 7285 DCNDLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AAS 7320

Query: 2438 PTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2496
              Q+  L ++Q +   E A+ K +  +SL   V     F ++   L  W+   +++++ Q
Sbjct: 7321 AIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 7378

Query: 2497 RVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
                  DL  I E + + K  M       P L+ L      L    +++E +     R++
Sbjct: 7379 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQ 7431

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +   W  +      R  +L   L     +LE  E   + L Q   KL     G Y    
Sbjct: 7432 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 7491

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
             Q++  E  Q     RQ   +  + +    +LL     DD  + ++    ++  W+ + +
Sbjct: 7492 EQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 7549

Query: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 2731
            R  +R   ++   R  Q++    EK   WL E      +    +    ++ R L D    
Sbjct: 7550 RAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQF 7609

Query: 2732 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 2791
            KE  K +   QG        Y    E  +++L S +   +A  LQ  L  +  KW     
Sbjct: 7610 KE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASM 7659

Query: 2792 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAF 2851
            +    +  L      W++    + + L  L+    +LS+  P            ++H   
Sbjct: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQ 7711

Query: 2852 KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEV 2911
             R  + +  V   T +  ++ L +  L                  A +++ +L ++ E +
Sbjct: 7712 MRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELL 7757

Query: 2912 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2971
              +WE+L    +  +++I E L       E   EL   L Q E         GD+LI+ +
Sbjct: 7758 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEM 7814

Query: 2972 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVA 3030
             + L+  K  + EIA  +EN   +  +  +L     +     +   L  +N RW+ L   
Sbjct: 7815 IEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872

Query: 3031 VEDRVRQLHE 3040
            +  RV++L E
Sbjct: 7873 IAARVKKLKE 7882



 Score =  179 bits (453), Expect = 6e-44
 Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)

Query: 333  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 392
            +L E+     +YQ +L+ + + + + E  L    E     E    Q   H+  M ++   
Sbjct: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013

Query: 393  QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
            Q  +  +   L  +L+    +    E+  +Q  + +L  R   +R+ +  K+  L   L 
Sbjct: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073

Query: 451  DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 498
            D      Q Q L+       EL+ WL  T+         P  P   D++ Q+   + +  
Sbjct: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131

Query: 499  DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 558
            ++EQ+ V ++ L+    V +E+      A  +++ + L  +              L+  L
Sbjct: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176

Query: 559  LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 605
            L+ QR L ++Q        EKE++   +  T      E L            SSLQ+   
Sbjct: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236

Query: 606  LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 647
            L+ +L ++K  +  + S  +++L        +                  +K+ A  D  
Sbjct: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295

Query: 648  ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 696
               W++L Q+       L+    Q  + V  ++P+   + V      V T+++  V    
Sbjct: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355

Query: 697  ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 745
                 A EE+       KRQ      + ++L   ++   +W+   E  L        +  
Sbjct: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412

Query: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
            E  +F +E    D+KE    +++ K          +  +QA  E   N  V  D++    
Sbjct: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462

Query: 806  EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 861
             +L+   S   + C  + ERL        I+ F N L+ L   T+ A+N ++ +Q     
Sbjct: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514

Query: 862  EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
                +  Q++  +   + L      I  LK +   L+ +      L        + + ++
Sbjct: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570

Query: 922  FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
               + +R   L    +     +Y+  +  +   ++  + K++       D +I+     E
Sbjct: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622

Query: 982  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
            +Q L    +E   GL       + + +K  S   +K      E+  +    +S +++   
Sbjct: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678

Query: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1097
            K   ++  + +  +H+   ++ ++     ++   P++G    + + L  ++   + L S 
Sbjct: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738

Query: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1157
            +   QP L  V + G+++         S LE++L +L   W     ++      L+  L+
Sbjct: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795

Query: 1158 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1215
                 Q + +++  W+  A++  E+  +      P EL+   + +    E +++ +A+  
Sbjct: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854

Query: 1216 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1273
            L +   S  + + +   V    L+ EL  + + +  L T +    + L ++         
Sbjct: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914

Query: 1274 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1322
             + +   W++ +E  + K  +NI    G + I E L   +      N  + + D  NQ  
Sbjct: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974

Query: 1323 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1382
            ++I +Q +           E+L   N  W+ L      + +LLE  ++S  E E ++  +
Sbjct: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034

Query: 1383 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440
            +      +K+L     I D+       ++ Q ++  + + E  +E+++++          
Sbjct: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085

Query: 1441 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1479
               + + Q K +DVS         L Q  AN +  + + K++L                 
Sbjct: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142

Query: 1480 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534
                 E +  L      +   E VQ Q+++  NL   L + +  ++       Q++++  
Sbjct: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202

Query: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1591
                + L   +  + + +N L  ++ E+ Q  +  L+L ++ +   K+     +      
Sbjct: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262

Query: 1592 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1645
             EL K +  + +    D EVA W +      K +   K  L  + E+GE LK  +     
Sbjct: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319

Query: 1646 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1702
              +  D+LSL         +  ++  +L   +L+Y    ETF ++++ +  WI++A+ +L
Sbjct: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375

Query: 1703 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1756
                    S+    Q++ + LK    + + + P +D   +    L  N  +  R      
Sbjct: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429

Query: 1757 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1814
            +  LN  ++ IS +  T + S     L Q  + ++K    +E  +Q    L  E      
Sbjct: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488

Query: 1815 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1862
               +    +E    E+  R   L   I D ++         R+E  +K  LL  +   + 
Sbjct: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548

Query: 1863 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1911
                QRR        QW +Y+  A+ L K L ++       L S+P P        DE +
Sbjct: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608

Query: 1912 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1969
             KE     Q+    L     +   LS D GA  A++    ++ ++W+    +   Q ++L
Sbjct: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668

Query: 1970 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2029
             F          ++   E     I+       T    +SQ+L +  + L+A  +  K+ E
Sbjct: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718

Query: 2030 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2089
            +      ++ +  D L Q S   D +     +A  SA  +    L E +  L  QWE++ 
Sbjct: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765

Query: 2090 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2146
                 R+ +    + +W  F    K   +WLT+ E  + +     I E  E  K     K
Sbjct: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820

Query: 2147 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2206
            + Q+ I   Q     L   GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L
Sbjct: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880

Query: 2207 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2264
            +E    + +  ++++    WL   ++  + P+  +    ++++ KL + + L  ++    
Sbjct: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940

Query: 2265 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320
             G+   LN     VL+    A  +  E D ++   +  + +W  +     E++ +IE   
Sbjct: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995

Query: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380
             +  +L +K  D   +      WL              +   F      I   AK+    
Sbjct: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037

Query: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2439
                       E    +  +R++ +  ++ + +N+  + L R  + D A  L  +     
Sbjct: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086

Query: 2440 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
            Q    + + V    T+I +      L   +    +F  A   +  WL+ +D  ++   + 
Sbjct: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135

Query: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
                 D+   I + KA  Q++     ++E++I   + L  K+   +A  II + ++ ++ 
Sbjct: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194

Query: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
               EV   ++   ++L  +     +   +  E E     A + L        ++ + Q  
Sbjct: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254

Query: 2620 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
               +  LA+ LR                 +W  + D++ DL   + R   ++D       
Sbjct: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310

Query: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2722
             ++    +      +S   +ALE   R L +  LD  +F     + + T N+++  T   
Sbjct: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363

Query: 2723 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2782
              L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   +
Sbjct: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417

Query: 2783 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2840
              +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   
Sbjct: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477

Query: 2841 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2900
            ++ Q    +  ++ +  ++ +I+S       F      E                     
Sbjct: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516

Query: 2901 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2960
            +R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K   
Sbjct: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576

Query: 2961 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002
             P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619



 Score =  176 bits (446), Expect = 4e-43
 Identities = 365/2049 (17%), Positives = 798/2049 (38%), Gaps = 282/2049 (13%)

Query: 343  RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 398
            RYQ+   +++ WL SA+D L    Q    +  ++E+V+D  +    +  ++ A      +
Sbjct: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858

Query: 399  ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 456
            +L  G++L+   +L + +   ++ +++ ++S+W  L       Q  LH++ MD       
Sbjct: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915

Query: 457  LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
            + E+  W++  E   +K E+        + +   +Q++K  + D+  +Q+ V+ +   V+
Sbjct: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975

Query: 516  VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
             +   D  S         EQL  +   W  +     ++  LL+ +L  W           
Sbjct: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035

Query: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 632
             W   +E  + + H  G  DQ  + ++L+    L+ DL K K+   ++  ++Q+ L+ ++
Sbjct: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLE-DLIKAKEK--EVEKIEQNGLALIQ 7090

Query: 633  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 692
            NK                              +S  V +T   L QT     +  +  + 
Sbjct: 7091 NKK---------------------------EDVSSIVMSTLRELGQT--WANLDHMVGQL 7121

Query: 693  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 752
            +IL+K   ++          ++  D     +++  + E    ++R   +  S E A+  +
Sbjct: 7122 KILLKSVLDQ------WSSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169

Query: 753  EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 812
              N  +L++     + EK E  R LQ        L+++        +++    +++N RW
Sbjct: 7170 VDNLQNLQD-----DLEKQE--RSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW 7220

Query: 813  IEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
                + ++E+L         W  Y++      + +QQ E  T      LK          
Sbjct: 7221 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT---NELLKAATNKDIADD 7277

Query: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQVF 922
             + + ++ C D +  L  ++  +  L      LK++        + +D ++ + H   + 
Sbjct: 7278 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 7337

Query: 923  SDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRLGE 981
              +  ++  LQ     L    + +++ A+  W+ ++E  L     S  +D   +++R+ E
Sbjct: 7338 QALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEE 7395

Query: 982  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
            L+            L  L+    E+  + P  ++ K     + +   W  +SSQ  E   
Sbjct: 7396 LKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTERFS 7449

Query: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1101
            KL+  + + +      +T  +++ + +  L  E    G+ + L +Q +   L  +++ + 
Sbjct: 7450 KLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSR 7507

Query: 1102 QPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVS 1161
            Q  L+S+   GQ++  + + +       +L  L+ QW  + ++   R+  +   + +   
Sbjct: 7508 QQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7567

Query: 1162 LQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKLLT 1218
             ++   ++ +W+   E  YL        P  LQ+A    +E++  ++   +++    L  
Sbjct: 7568 YREMAEKLRKWL--VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTV 7625

Query: 1219 ESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE----LLSY 1274
            E+   ++  A   A+ AL+ EL  +   ++    RL  + K L  +   W +    +   
Sbjct: 7626 EAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 7685

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLT 1331
            LEK         FK K ++++P   EE+         LEN +    D+  Q+ +L  TL+
Sbjct: 7686 LEKLR------TFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739

Query: 1332 DGGVMDE--LINEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLH-------- 1380
                 D+  ++NE +E    +W EL H+ ++RRQ++ E+  + A  +EK+          
Sbjct: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799

Query: 1381 ----------LIQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEE 1426
                      LI+E +  + K     IA    +K+   QM +   K      SHE    E
Sbjct: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASE 7854

Query: 1427 MK-KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1485
            ++ K  +  +  Q +L  I    KKL++  +  +        ++ +   +  L  ++  L
Sbjct: 7855 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ------QLDKNMSSLRTWLAHIESEL 7908

Query: 1486 -PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK----KQTENPKE 1540
               +   S   E +Q +LN    L + + +  + V  V+     ++              
Sbjct: 7909 AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS 7968

Query: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
            + +    L   +  + A   ER+ ++E+  +L +K   + +   +WL +++      S+ 
Sbjct: 7969 IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS 8028

Query: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL---- 1656
              + +    E+   +A Q+++ +    L+ I +    L      +E   +   SL     
Sbjct: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLKQMVH 8083

Query: 1657 --NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1714
              N  W  +  R    L  L  +    E F+   D I  W+ + D  L   E       +
Sbjct: 8084 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8143

Query: 1715 DVLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1771
              +K+LKA   E++    K++    Q   L+         ++E ++ EL      +  R+
Sbjct: 8144 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 8203

Query: 1772 KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRG 1831
            +     +    L     D    L   E E++    L +  ++ D + D+  + +      
Sbjct: 8204 ERYHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLS 8258

Query: 1832 DNLQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKK---------------- 1871
             +L Q +  ER   +       +  +    ++  +DL S   +                 
Sbjct: 8259 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8318

Query: 1872 --ALEISHQWYQYKRQADDLLKCLDD-----------IEKKLASLPEPRDERK------- 1911
              A+ +S      + Q   L K LDD           I  K  + PE     K       
Sbjct: 8319 RGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLG 8378

Query: 1912 --------IKEIDRELQKKKE------ELNAVRRQAEGLSE-----DGAAMAVEPTQIQL 1952
                    +K ++ +L++++E       L++   Q  G+ +        A++ E    Q 
Sbjct: 8379 ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438

Query: 1953 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
             ++W++  S         +A +    EE   +   ++  +I  +    + ++  + +A+ 
Sbjct: 8439 LQKWQQFNSDLNSI----WAWLGDTEEELEQLQRLELSTDIQTI-ELQIKKLKELQKAVD 8493

Query: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
              + ++ + +LC+ +F     +E   ++++D L Q +GR                     
Sbjct: 8494 HRKAIILSINLCSPEFTQADSKES--RDLQDRLSQMNGR--------------------- 8530

Query: 2073 KLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK--- 2129
                        W++V  + ++ +G    ++ + + FH   ++ +  L   E   R+   
Sbjct: 8531 ------------WDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNE 8575

Query: 2130 -TQIPENWEH---AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKL 2185
               I  N +      +   L +++  + + Q  V +L     +++  +  TD    +EK+
Sbjct: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKV 8635

Query: 2186 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2245
              +  R + + K++S   K LE+  ++ S  Q+DL+ +    +E D   S+    G+   
Sbjct: 8636 HVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTP 8693

Query: 2246 LKEKLEQVK 2254
             ++K  + K
Sbjct: 8694 NRQKTPRGK 8702



 Score =  172 bits (435), Expect = 7e-42
 Identities = 533/3032 (17%), Positives = 1167/3032 (38%), Gaps = 426/3032 (14%)

Query: 357  SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 408
            S E+ +    E+    E + D  +  E   + L  HQ +   I         Q+     G
Sbjct: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302

Query: 409  TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 467
             G L +       E++  L S  + L   S E+Q    R+ + L+  +  E N + + + 
Sbjct: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355

Query: 468  EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 522
              +T    E  L    LE L  +++Q K   +  E   V+  +L      V E+S    G
Sbjct: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409

Query: 523  DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 582
                  L++Q K + ++   +    E+    ++ +  KW          S W++EKE  +
Sbjct: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469

Query: 583  NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 634
            N + T+      +M  S  K+ + + +        LE++ QS  +  +  +      K  
Sbjct: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527

Query: 635  SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 677
             + +  E  L   A+C +  +       QK E++  +I Q+V+  +  L          T
Sbjct: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586

Query: 678  QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 712
            +T             +E++++  T      R+ +      +E      Q        K+R
Sbjct: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646

Query: 713  QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 769
            Q  +++ +   +RL+ +++   +W+ R EA   SPE  I           + + A++ E 
Sbjct: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706

Query: 770  --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 827
              +A  + KL     S  ++  +      +   +K   EQL+ RW +  Q++++R+N+L+
Sbjct: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761

Query: 828  YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 882
               +++A   + QQ +++  +   W+K+   +  T SE + +  Q+ +   KD    +  
Sbjct: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815

Query: 883  LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940
             + +++ L+     L   G+      L          F++    V+ R+  L  + + L 
Sbjct: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874

Query: 941  PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 1000
              +   ++S I   ++Q  T  +   ++  + +++E+ L +      +L+     L  + 
Sbjct: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930

Query: 1001 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1060
            +  +   K   SE     ++  +++ G  +++ + L     + +      +  Q+  + L
Sbjct: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990

Query: 1061 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1120
             K + +++    +E       + L+++L+    L  ++ + +  L  + +  ++I  + +
Sbjct: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049

Query: 1121 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180
              FA  ++ E+  L   WD   + ++  +    G ++     Q   S + + +  A    
Sbjct: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109

Query: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1237
            + R    K  ++L+ A  + + AK +   K+  +   T     ++++   +       +K
Sbjct: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168

Query: 1238 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1293
             ++E+    +  +  +L      L    + W ++LS  ++   W N    ++   +   +
Sbjct: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228

Query: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
            N     E + E    ++N     E+  +++  L +   +     +L   E +        
Sbjct: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288

Query: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1408
                 V +  L + + QS Q  EK ++ I    T +++ L     ++   A      + +
Sbjct: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347

Query: 1409 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1465
            E Q  QS+++S + +L  +  K H+   E+  R ++ +    + +  +  K +   + + 
Sbjct: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407

Query: 1466 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1523
              +F + +QE +      K        ++ + +V++++L+   N+  S+S+ +S+++ V 
Sbjct: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467

Query: 1524 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1583
            + G+ +      +    + E++T     +     +  + KQ L+ C         +   L
Sbjct: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527

Query: 1584 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1643
              W+     E+ +R   E    NL          + E+ K ++ L  +    E+L  +  
Sbjct: 2528 NLWI----HEMEERFNTE----NLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579

Query: 1644 KKETLVEDK----------LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1693
            + + L E+             LL S+   +    E+  +  +  Q+H E  ++ +  +  
Sbjct: 2580 RGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH-EALEEALQSMWF 2638

Query: 1694 WIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI-------RPKVDSTRDQAANLMANRG 1746
            W+      L  +E       +D L++  +++ DI         K++    +    + +  
Sbjct: 2639 WVKAIQDRLACAE--STLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2696

Query: 1747 DHCRKLVEPQISELNHRFAAIS----HRIKTGKASIP-----LKELEQFNSDIQKLLEPL 1797
               +++++ Q+  L   +A I     H   T ++ I      ++   Q    ++ + + +
Sbjct: 2697 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756

Query: 1798 EAEIQQGVNLKEEDFNKD-------MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
            E  +Q    LKE+    D         ED+   +  L+ +   L ++  DE  ++     
Sbjct: 2757 EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKD---TA 2813

Query: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
            Q+ L+T+ N +  +  ++ +K  EI            D L  LD                
Sbjct: 2814 QEELKTQFNDIMTVAKEKMRKVEEI----------VKDHLMYLD---------------- 2847

Query: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
             + E    L   KEEL+    +   +S D +A     TQ +LSK    I+S+     RL+
Sbjct: 2848 AVHEFTDWLHSAKEELH----RWSDMSGDSSA-----TQKKLSKIKELIDSREIGASRLS 2898

Query: 1971 FAQ--IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDF 2028
              +     V++ T     E M  E+  + + +      V Q    +E L++   L  ++F
Sbjct: 2899 RVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2958

Query: 2029 EDLFKQ-EESLKNIKDSLQQSSGRIDIIHSKKT---------------AALQSATP-VER 2071
                 Q E++L+     L+  + ++ ++  K T                ALQ A P  E 
Sbjct: 2959 SGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018

Query: 2072 VKLQ-----EALSQLDFQWEKVNKMYKD--------RQGRFDRSVEKWRRFHYDIKIFNQ 2118
            +K Q          L     KV+ + K+         +G  ++     +RF    + F Q
Sbjct: 3019 LKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQ 3078

Query: 2119 WLTEAEQFLRKT-QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN---ATGEEIIQQSS 2174
            WL  A+    K   IP+N         L+++Q+ + + +     LN   + GE +    +
Sbjct: 3079 WLVNAKITTAKCFDIPQNISEVSTS--LQKIQEFLSESENGQHKLNMMLSKGELLSTLLT 3136

Query: 2175 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL------- 2227
            K  A  +Q K+ +    W+     L  ++  LE  K  + +F+        WL       
Sbjct: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196

Query: 2228 -EEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 2286
             E ++ +  +P +  ++Q+L+  LE++     +L   +   +QL E              
Sbjct: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE-----------GQA 3245

Query: 2287 EQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSP 2346
                  +++ Q + Q++ +S    EK   ++  + +  Q    +++L++       W++ 
Sbjct: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQD-------WMTD 3298

Query: 2347 IRNQLEIYNQP-NQEGPFDVQETEIAV-----QAKQPDVEEILSKGQH-LYKEKPATQPV 2399
              + L+ Y  P + +   D +  ++       Q K+  ++ I+++G+  L    P   P 
Sbjct: 3299 AIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3358

Query: 2400 ----------------------KRKLEDLSSEW--------------KAVNRLLQELRAK 2423
                                  K +LE   S+W               ++   L E   +
Sbjct: 3359 IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ 3418

Query: 2424 QPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLM-------LEVPALADFN 2476
              +L    T +G +      L+ + V++  + +  +E+  + M       LE+  L +  
Sbjct: 3419 HAELRDKTTMLGKA-----KLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3473

Query: 2477 RAWTELTD-------------------------WLSLLDQVIKSQRVMVGDLEDINEMII 2511
            RA  E                            WL    + +    V+ GD         
Sbjct: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH------- 3526

Query: 2512 KQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI------ITDR-IERIQNQWDEV 2564
              + T++DL++ +    E     Q L N   +     I        DR +E ++  W   
Sbjct: 3527 THETTLRDLQELQVHCAE----GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY 3582

Query: 2565 QEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 2624
            Q  L   R Q N ++       +  ++ ++ L  A  K+             + ++ + K
Sbjct: 3583 QHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMK 3642

Query: 2625 QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 2684
            +  +++  ++  V+     A ++L D S  ++R     T+ + + ++++  +V E+   L
Sbjct: 3643 KWHEEVTAYRDEVEEVGARAQEIL-DESHVNSRMGCQATQ-LTSRYQALLLQVLEQIKFL 3700

Query: 2685 EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 2744
            EE  + L++    L  +  W     T  N    AT+ +++  D+  + + +K  + L  +
Sbjct: 3701 EEEIQSLEESESSLSSYSDWY--GSTHKNFKNVATKIDKV--DTVMMGKKLKTLEVLLKD 3756

Query: 2745 IEAHTDVYHNLDENSQKILRSLEGSDDAVL---LQRRLDNMNFKWSELRKKSLNIRSHLE 2801
            +E    +  +  E  ++ ++ LE  +   L   +   ++ +    S +RK+ + +   L 
Sbjct: 3757 MEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLH 3816

Query: 2802 AS---SDQWKRLHLSLQELLVWLQLKDD---ELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
             +   SD+ K L   + E    L + ++   EL  +      + ++Q+    H    + +
Sbjct: 3817 LAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV 3876

Query: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
            + K   ++  ++ V +   +  ++ L+  YQ+   +  E       ++  K  E+ N+E 
Sbjct: 3877 REKGEALLELVQDVTL---KDKIDQLQSDYQDLCSIGKEHVFSLEAKV--KDHEDYNSEL 3931

Query: 2916 EKLNLHSADWQ-RKIDETLERLQELQEATDELDLKLRQAEVIKG------SWQPVGDLLI 2968
            +++         R +   L     L+  T +L       E I G      + Q  GD LI
Sbjct: 3932 QEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI 3991

Query: 2969 DSLQDHLEKVKALRGEIAPLKENV-SHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL 3027
                DHL+         A LK+NV +H+       + +         S   +L       
Sbjct: 3992 GQCADHLQ---------AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK----- 4037

Query: 3028 QVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPK 3087
             V+ +D ++Q     + +  A Q  L  S Q P  RA +  +V ++   + Q   +    
Sbjct: 4038 HVSRQDTLQQC----QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTY---- 4089

Query: 3088 MTELYQSLADLNNVRFSAYRTAMKLRRLQKAL 3119
              +L  S+ DL+N   S   TA  +++ ++ +
Sbjct: 4090 -LDLLCSMCDLSNA--SVKTTAKDIQQTEQTI 4118



 Score =  172 bits (435), Expect = 7e-42
 Identities = 589/3144 (18%), Positives = 1177/3144 (37%), Gaps = 541/3144 (17%)

Query: 276  QQITVSLAQGYERTSSPKP----RFKSYAYTQAAYVTTSDPTRSPF----PSQHL-EAPE 326
            +Q   S+ Q  E    P+P    +F    + Q+      D TR+       S+ L E  E
Sbjct: 2746 EQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2805

Query: 327  DKSFGSSLMES-EVNLDRYQTALEEVLSWLLSAEDT----LQAQGEISNDVEVVKDQFHT 381
            D+SF  +  E  +   +   T  +E +  +          L A  E ++ +   K++ H 
Sbjct: 2806 DESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2865

Query: 382  HEGYMMDLTAHQGRVGNILQL-GSKLIGTGKLSEDEETEVQEQMN-------LLNSRWEC 433
                  D +A Q ++  I +L  S+ IG  +LS  E    + + N       L+++  + 
Sbjct: 2866 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQA 2925

Query: 434  LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 493
            LR    + + ++ +    L+N   +               + E+     +  L++ ++Q 
Sbjct: 2926 LRADWKQWEDSVFQTQSCLENLVSQ-------------MALSEQEFSGQVAQLEQALEQF 2972

Query: 494  KVLQEDLEQEQVRVNSL-THMVVVVDESSGDHATAAL---EEQLKVLGDRWANICRWTED 549
              L +   Q+   +    T   +V     G     AL   E + + L  +   +CR++ D
Sbjct: 2973 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRD 3032

Query: 550  RWVLLQDILLKWQRLTEE-QCLF---SAWLSEKEDAVNKIHTTGFKD------------- 592
                L     K   L +E  CL    S     KE  + +     F+D             
Sbjct: 3033 ----LSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTA 3088

Query: 593  ------QN--EMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL----KNKSVTQKT 640
                  QN  E+ +SLQK+    ++ E  +  +  + S K +LLSTL    K K +  K 
Sbjct: 3089 KCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS-KGELLSTLLTKEKAKGIQAKV 3147

Query: 641  EAWLDNFARCWDNLVQK---LEKSTAQISQAVTTTQP-----SLTQTTVMETVTTV---- 688
             A  +++     NL QK   LE    Q+     + +P     S T+  V E+   +    
Sbjct: 3148 TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3207

Query: 689  -TTREQILVKHAQEELPPPPPQKKR---------------------------QITVDSEI 720
               REQ  ++   EE+    PQ  R                           Q    S +
Sbjct: 3208 AKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNL 3267

Query: 721  RK----RLD----------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE-KVNA 765
             K    RLD          + I EL  W+T +  +L S  +     + +  D +  K+ A
Sbjct: 3268 TKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDS--YCHPTSDKSVLDSRTLKLEA 3325

Query: 766  IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC--------Q 817
            +   K EK  +++      +++++    EG+   +I+Q  + +   W            Q
Sbjct: 3326 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGI--PTIQQQLQSVKDMWASLLSAGIRCKSQ 3383

Query: 818  LLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEV 877
            L      W  YQ+ +  F   +  +E     +E     Q     + T +  + K+  +EV
Sbjct: 3384 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESER----QHAELRDKTTMLGKAKLLNEEV 3439

Query: 878  NRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 937
               S L   +E ++++   + E     + L           ++ +  +Q R KE  T  +
Sbjct: 3440 LSYSSL---LETIEVKGAGMTEHYVTQLELQ--------DLQERYRAIQERAKEAVTKSE 3488

Query: 938  TLPPMR--YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSG 995
             L  +   YQ  + A   W+ Q + KL    +   D    E  L +LQ LQ    E Q+ 
Sbjct: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA- 3547

Query: 996  LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1055
               L++ +       PS I +      E +   W+    +L E   +    +NKLR ++ 
Sbjct: 3548 --LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605

Query: 1056 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
              Q + +W+   +  +        +    + QL Q +    ++   +  +  V    Q+I
Sbjct: 3606 KFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEI 3665

Query: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
             +E+     SR+  +  +L +++  +  QV  + + L+  ++     +  LS   +W   
Sbjct: 3666 LDESHVN--SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723

Query: 1176 AEEEY------------LERDFEYKTPDELQKAVEE----MKRAKEEAQQ-----KEAKV 1214
              + +            +    + KT + L K +E+    +K A+E+ ++     +E + 
Sbjct: 3724 THKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA 3783

Query: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
            + L + ++  + Q   +    ++KE  TL      L    + KCK L +  A + E+L  
Sbjct: 3784 ERLRKEIHDHMEQLKELTS-TVRKEHMTLEKGLH-LAKEFSDKCKALTQWIAEYQEILHV 3841

Query: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
             E+    L E + +L   +              SL+  +   E +   +R   + L +  
Sbjct: 3842 PEEPKMELYEKKAQLSKYK--------------SLQQTVLSHEPSVKSVREKGEALLEL- 3886

Query: 1335 VMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQE---------- 1384
            V D  + ++++   S +++L          LE  ++  ++    L  +++          
Sbjct: 3887 VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946

Query: 1385 --------SLTFIDKQLAAYIA---------DKVDAAQMP------QEAQKIQSDLTSHE 1421
                    SL  I +QLA + A         D+++  QM       Q A  +Q+ L    
Sbjct: 3947 APDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK--- 4003

Query: 1422 ISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEV 1481
               + +  H QG + +   +     AQ+  Q +  +    QK  + +  LQ+ +  L  V
Sbjct: 4004 ---QNVHAHLQGTKDSYSAICS--TAQRMYQSLEHEL---QKHVSRQDTLQQCQAWLSAV 4055

Query: 1482 KMHL------PALETKSVEQ----EVVQSQLNHCVNLYKSLSE-----VKSEVEMVIKTG 1526
            +  L      P    ++++Q      +Q Q    ++L  S+ +     VK+  + + +T 
Sbjct: 4056 QPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE 4115

Query: 1527 RQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE 1585
            + I QK  Q +N  +  E +  LK   +EL   + +  QQL+   +  R    E+N+   
Sbjct: 4116 QTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RHSELELNIAQN 4170

Query: 1586 WLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 1645
             +          S V+     L S+ A                 S+  + E +  +  K+
Sbjct: 4171 MV----------SQVKDFVKKLQSKQA-----------------SVNTIIEKVNKLTKKE 4203

Query: 1646 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD-------HITKWIIQA 1698
            E+    +++ LN  W+ +  ++    NL L+ ++ ++      D        + K+  + 
Sbjct: 4204 ESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4260

Query: 1699 DTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 1758
            D L   S+ +      + LK+L   L + +  ++  +DQ   ++ +     ++LV+ Q S
Sbjct: 4261 DNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTS 4319

Query: 1759 ELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE-------D 1811
             L  R+  +   IK  K  + +  LE+ N    +  E +E   +Q  N+ E        D
Sbjct: 4320 HLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPD 4378

Query: 1812 FNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQLLQTKHNALK 1862
              +++  D+     EL  +   L+  I D           +R+ I+      Q+  N L 
Sbjct: 4379 MAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLS 4438

Query: 1863 DLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEPRDERKIKEID 1916
            DL  QRRK   KAL    Q+     QA   ++  +      + +  LP+      + +  
Sbjct: 4439 DLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD-----VSKQV 4493

Query: 1917 RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT 1976
            +  +  +  L   + +  GL   G  +  E T+ + S+   +++   + +  +     H 
Sbjct: 4494 KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR 4553

Query: 1977 VREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CAKDFEDLFKQE 2035
            ++E           LE + V   +  E    +   L+   ++  P++    +  +L  Q 
Sbjct: 4554 LQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQL 4602

Query: 2036 ESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDR 2095
               +NI +   +    +  +       L S   V+   L E L+ L  Q+  +  + KD+
Sbjct: 4603 AKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK 4662

Query: 2096 QGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQ 2154
              +   ++   + +   I++  Q L+E E QFLR +++P +    +       LQDG   
Sbjct: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE----ALSLQDGCRA 4718

Query: 2155 RQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKN 2211
                V  L    +E+ Q+      T      +K+  L   +  + +Q   R   LE+  +
Sbjct: 4719 ILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4778

Query: 2212 ILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQLKEKLEQVKLL 2256
               E ++   +    L+         N  ++P E          G  Q     L++V + 
Sbjct: 4779 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4838

Query: 2257 VEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 2310
            +E+L     PL  +    Q+    G + +      E   + E+++ Q+     ++SR+L 
Sbjct: 4839 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4898

Query: 2311 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ----------- 2359
              +  ++A++     L+  L+D++E++  + +    +++ L I N  +            
Sbjct: 4899 WLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4957

Query: 2360 --------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE------------- 2392
                          E   D+QE   A++ +Q  + EI S+ Q  Y+              
Sbjct: 4958 LISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQE 5014

Query: 2393 -----------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 2441
                       + A + +K  +E  S+E    +  L+EL +    L P +   G    + 
Sbjct: 5015 LLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKEDLE- 5072

Query: 2442 VTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWLSLLDQVIKSQ 2496
                 Q V + E    ++   S   +++         D+ +A  E+ + ++  ++ +   
Sbjct: 5073 -----QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEF 5127

Query: 2497 RVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
             ++      +  E + + KA +  +     ++  L   A  L+ KT N  ++  ++  + 
Sbjct: 5128 SLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDASKATLSRSMT 5186

Query: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
             +  +W  ++   Q++ + L + + + T +    ++A +++ Q + KL        +   
Sbjct: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246

Query: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHMIT-------- 2663
            +   +        +L Q Q+ + +     L +L+D +A    ++   +  IT        
Sbjct: 5247 LLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLN 5306

Query: 2664 --ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLDLEKFLAWLTE 2707
              E +  + + + + + +RE            ++ET   L     +    LE+    LTE
Sbjct: 5307 MQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE 5366

Query: 2708 AETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQDLQGEIEAHTD 2750
            A      ++    +++                 L E +  +K +  Q QD   E+E    
Sbjct: 5367 ATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIKEVEQSKA 5425

Query: 2751 VYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
                L    QK+ + L               +   D  +L   LD  N K  EL      
Sbjct: 5426 TSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMEL---DAA 5482

Query: 2796 IRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2854
            ++  LE +    K L   + +L  +  Q      +R + +      +++ N++     + 
Sbjct: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542

Query: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914
            ++  + +   T+         +     + L +E +E+  E  A  +T  L+       T 
Sbjct: 5543 IEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKLQYLTSVYCT- 5599

Query: 2915 WEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 2970
             EK++   A+  R+ +E  +    RLQ LQ+A    D+K  +AE+ K             
Sbjct: 5600 -EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK------------- 5643

Query: 2971 LQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLSPYNLSTLEDL 3020
            LQ  LE+ +A       G ++ LKE +SH   L  ++ +L      +QL    L   ED+
Sbjct: 5644 LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDV 5702

Query: 3021 NTRWKLLQVAV---EDRVRQLHEA 3041
                 L   A+   E+  R  H A
Sbjct: 5703 VASLPLCHAALRLQEEASRLQHTA 5726



 Score =  167 bits (423), Expect = 2e-40
 Identities = 526/3006 (17%), Positives = 1150/3006 (38%), Gaps = 446/3006 (14%)

Query: 350  EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 407
            E+  +L  A+  LQ      +++E  + ++     + ++  L + Q  V  I++      
Sbjct: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195

Query: 408  GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 467
               KL++ EE+   +++N LN +W       + +QSN   +  +   Q+ ++ +D +   
Sbjct: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249

Query: 468  E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 511
            E          +   + + E     LE LK+    +Q+ K   EDL+   Q+ +   +L 
Sbjct: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309

Query: 512  HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 552
               +V +++S  +     LE              E+L V+  R+  +  W E++      
Sbjct: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369

Query: 553  -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599
                         LL D L     L  +Q L  + + + +  +  +     +   + LS 
Sbjct: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429

Query: 600  LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 654
             Q      +DL  ++++ + K  S K Q L++  +  S  Q+ E  +   ++     D+ 
Sbjct: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488

Query: 655  VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 705
            V K  K+      ++ T Q  +T       E +  VT +E+  V    +EL         
Sbjct: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548

Query: 706  PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 765
                + +++  +   RK    D  +   W+ +++ ++  PE  +  +         K   
Sbjct: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607

Query: 766  IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 825
            I  +  E    L    R+ Q ++  +     N       SE+LN+   +F  +++   + 
Sbjct: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662

Query: 826  LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 879
                   I    +   L ++TT + + L+ Q    S+ PT  A++  L +   C+  ++ 
Sbjct: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722

Query: 880  LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 939
            ++GL   ++ L  +    +  GQ P   D      T + +      +  E+ +  + DT 
Sbjct: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777

Query: 940  PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 995
               +  E M       QQ E +L      Q  V +  +  E++L    +L  SLQ+    
Sbjct: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831

Query: 996  LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1055
            L  ++  +++++         K + + +  +G  K L+S + E   + E +M +    Q 
Sbjct: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891

Query: 1056 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
             +     W+  V   L        + + +++++++ ++   ++Q+    +N+++   ++ 
Sbjct: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951

Query: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
              +A+   ++ LE  L EL+     + + +  R+  L     +     +     ++W+  
Sbjct: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011

Query: 1176 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233
            A+E  +      + ++ +E  K+  E    +++      ++  L  +++ +I    P  +
Sbjct: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068

Query: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1288
            E L++++ +L    Q +      +   L+   A WH+     E+  + +N+ E     F 
Sbjct: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128

Query: 1289 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1342
            L  T +     E++SE      V++S    +   E+  +Q+       T        ++ 
Sbjct: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183

Query: 1343 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1402
             + T   RW  L   A  ++K+LE ++         +    E +  +  +L    A+K  
Sbjct: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243

Query: 1403 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAAQRVLSQIDVAQ 1448
             A++              ++ Q     L    +S L++      G+E    ++ +I   Q
Sbjct: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPP--LMQEITAMQ 5301

Query: 1449 KKLQDVSMKFRLFQKPANFEQRLQESKMI----------LDEVKMHL--PALETKSVEQE 1496
             +  ++  K +   K    +Q L++ +M+          + E K +L  P +E       
Sbjct: 5302 DRCLNMQEKVKTNGKLV--KQELKDREMVETQINSVKCWVQETKEYLGNPTIE------- 5352

Query: 1497 VVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---N 1553
             + +QL     L    +  +  +E + +  ++      T  P EL  ++  + L     +
Sbjct: 5353 -IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRD 5411

Query: 1554 ELGAKVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDS 1609
            ++  K+ E +Q      +LSR+++K       +LT+  A TD  +  ++  + +   LD 
Sbjct: 5412 QIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG 5471

Query: 1610 EVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
                     K +E      K + + G+     LGK       KL+ L+   I    +AE 
Sbjct: 5472 ------CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAEN 5517

Query: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELN 1725
             L+ L +   H+E +++ ++ I KWI +A  L   +       Q +E  +  + L  E  
Sbjct: 5518 RLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESK 5577

Query: 1726 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKEL 1783
            +I  ++++  ++   L +    +C + +  Q++EL      +   IK    ++    K++
Sbjct: 5578 EIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDM 5634

Query: 1784 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1843
            ++F ++++KL   LE   Q    L   +  +   ++     + LL   ++L+ ++     
Sbjct: 5635 KKFEAELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV----- 5686

Query: 1844 REEIKIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
             + +++ Q  L+   + +  L       + +++A  + H   Q        +   +  E+
Sbjct: 5687 -QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5745

Query: 1899 KLASLPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWR 1957
            ++  L     ++ I+   RE++ K    + ++  QA+    +  A  ++  Q Q++    
Sbjct: 5746 EMKHL-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL-- 5798

Query: 1958 EIESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVS 2008
              + K    +  +   + TV E E +   TED+  E+   PS + + +        T +S
Sbjct: 5799 NSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLS 5858

Query: 2009 QALLE-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKK 2059
                E         +++P  C              ++I      S+ R+      IH   
Sbjct: 5859 PVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPST 5918

Query: 2060 TAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQW 2119
            +A+ +   P         L  L   WE +  +  ++Q     ++E+ +++   ++  +  
Sbjct: 5919 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 5978

Query: 2120 LTEAEQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
            +   E  L ++  P      +  EH      +  LQD I + Q      ++  EE++ +S
Sbjct: 5979 MEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSES 6032

Query: 2174 SKTDAS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDL 2220
             + D +    LQ  L  L  R   +  + S +++ LEE          Q+  L  ++ + 
Sbjct: 6033 CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEA 6092

Query: 2221 NEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 2279
            +E   WL          L P KE   ++ +L   + ++ E+  +   L +L+     +L+
Sbjct: 6093 DELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLL 6152

Query: 2280 SAPI-SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLN 2338
                 + +E ++L  KL++     +++ RAL +KQ  ++   ++  + E  ++    Q  
Sbjct: 6153 EGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSP 6210

Query: 2339 HLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY-------- 2390
             +  WL+  R     + Q  Q      +E E  +  ++  +  + S+G+ +         
Sbjct: 6211 GVQEWLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAET 6267

Query: 2391 ----KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD----- 2426
                 EKP               A   ++ K E L  E+    +LLQ +  ++ +     
Sbjct: 6268 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYS 6327

Query: 2427 ----LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADF 2475
                L  G+    G  PTQ  + VT  +     A  ++   S      S+ LE       
Sbjct: 6328 RPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGV 6387

Query: 2476 NRAWTELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD----- 2519
            +   T L D    L           +  + +Q ++  D+++++E + K K          
Sbjct: 6388 SATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPEN 6447

Query: 2520 ------------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII 2550
                                    + QR  Q++E +    N +N      TS  + + II
Sbjct: 6448 GDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII 6507

Query: 2551 ------------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK----- 2580
                         ++IE IQ   D ++E              LQ  +  + E+ K     
Sbjct: 6508 LQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMY 6567

Query: 2581 ------------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQ 2625
                           Q L  K + E+ L      LE+ +E   G   +    K+  E +Q
Sbjct: 6568 DELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQ 6625

Query: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
            L    +++   ++    L   L R   +   +K       + A   ++ KR  +R   LE
Sbjct: 6626 LLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6685

Query: 2686 ---ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2742
               ET   L +   +L + L  +  +  +  ++++   ++RL+       + +  +Q L+
Sbjct: 6686 YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLK 6736

Query: 2743 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2802
              +  +    + + ++ +++L S+  SD    L+ +L+ +   W     K       LE 
Sbjct: 6737 SSLNEYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLET 6792

Query: 2803 SSDQWKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2858
                W R      +L+ WLQ   D L     +   +  +   V+   +    F +E+  +
Sbjct: 6793 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6852

Query: 2859 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2918
              +  S L T    L  + ++                     T  LR +   ++++W  L
Sbjct: 6853 SSLKSSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDL 6891

Query: 2919 NLHSADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLE 2976
              +    Q K+ +  +++L      ++ +  + L +  + K        +   ++ ++L+
Sbjct: 6892 LTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQ 6951

Query: 2977 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 3032
            K K  + +I   +  V  VN    Q+++  ++    + +   +    +N  W++LQ  V 
Sbjct: 6952 KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT 7011

Query: 3033 DRVRQL 3038
            ++++ L
Sbjct: 7012 EKIQLL 7017



 Score =  159 bits (401), Expect = 6e-38
 Identities = 495/2699 (18%), Positives = 1027/2699 (38%), Gaps = 459/2699 (17%)

Query: 417  ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 476
            E     ++  L   WE L+    EKQ  L+  L + Q +    L    TK E    K+ E
Sbjct: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988

Query: 477  EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 532
             P        + Q+ +H+ L +++   Q  +N L   +   +V +    D A   AL+  
Sbjct: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046

Query: 533  LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 580
            L VL +R + I      +  LL++ L   L+ QR  +EQ L           +WL   + 
Sbjct: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104

Query: 581  AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 640
             ++   +   K+  +M + L     +  ++E+K  ++ +L    ++LL  L+ K+ T+  
Sbjct: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161

Query: 641  EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 696
               L    R       +L+ S  ++ +A+   Q ++ Q T  E     V    T+   + 
Sbjct: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213

Query: 697  KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
            +   +       Q++  +    E+ + L    + L S  +R E +L              
Sbjct: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259

Query: 757  SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 816
                     I+   AE      DA      L +++  EG  +     A +Q+  +W    
Sbjct: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303

Query: 817  QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 874
            Q  S +   L+   N++      Q+ EQ+  +  N L   +       PT  KS +    
Sbjct: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351

Query: 875  DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 934
               + L GL    E +  QS   K +              + H +Q   D          
Sbjct: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385

Query: 935  IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 994
                         +SA  TW+   E +L +    +   E  E  L   + L   ++E   
Sbjct: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431

Query: 995  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1047
             +        + +K   S+   +     + IE       GR   L S + + C +++E++
Sbjct: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483

Query: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1107
             ++   QN ++ L   +A+    + ++   + +  +  +Q++  +     ++     +  
Sbjct: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542

Query: 1108 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1167
            +   G K++ E +P        EL +L   +D +   + +R+  L   L      ++ L 
Sbjct: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596

Query: 1168 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226
            ++ + +   +E+   ++     + +E+Q+ ++   + KE  Q  E+ + +LTE++   I 
Sbjct: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652

Query: 1227 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1283
                    A++KE +    L      +  R + +   LE +   W  L    ++ ++ L 
Sbjct: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706

Query: 1284 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1333
             VE  + +     G  EE  + L     L +H + + N+ +  L Q L DG         
Sbjct: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762

Query: 1334 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1390
              ++  +N+  E + S   ++ +E  R + +L+   +   E+   +H +Q   + L F  
Sbjct: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822

Query: 1391 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1450
            +Q          +  +PQE + ++  L +     +E+   +  K +     +Q+ +  KK
Sbjct: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871

Query: 1451 LQDVSMKFRLFQKPANFEQRLQESKMILDEV-KMHLPALETK----------SVEQEVVQ 1499
            +   +++  L +  + +   L     + +++ ++ +  L ++          S+ + V+Q
Sbjct: 6872 VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQ 6931

Query: 1500 SQLNHCVNL--YKSLSEVKSEV------------------EMVIKTGRQIVQKKQTENPK 1539
               ++  N   YK++ E   +                   + V++   Q V+ K+++   
Sbjct: 6932 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-T 6990

Query: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
            +  E++ A+   +  L   VTE+ Q LE  L+   +    +  L  W    +  L ++  
Sbjct: 6991 DFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHR 7050

Query: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE---TLVEDKLSLL 1656
            + G  +++ + +   +  +  I+ ++  ++ I + G AL  +  KKE   ++V   L  L
Sbjct: 7051 I-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL--IQNKKEDVSSIVMSTLREL 7107

Query: 1657 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE-----SEKKKPQ 1711
               W  +     +   LL        +     D I  ++++A   L          +  Q
Sbjct: 7108 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7167

Query: 1712 QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF----AAI 1767
             + D L+ L+ +L      +         L+        + +   + E+N R+      I
Sbjct: 7168 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 7227

Query: 1768 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE------ 1821
            + ++++ KA + L   +++    ++    ++ +  +   L +   NKD+ +D        
Sbjct: 7228 AEQLQSSKALLQL--WQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 7285

Query: 1822 --------GTVKELL----QRGDNLQQRI----TDERKREEIKIKQQLLQTKHNALKDLR 1865
                    GTVK+ L    + G+ L+Q++        + +++ + Q L   +    K   
Sbjct: 7286 CNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQT 7345

Query: 1866 S--------QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1917
            S        +   K+LE    W     +A+++L+  D             D   I+E   
Sbjct: 7346 SLQAGVLDYETFAKSLEALEAWIV---EAEEILQGQDPSHSS--------DLSTIQERME 7394

Query: 1918 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ----LSKRWREIESKFAQFRRLNFAQ 1973
            EL+ +  + +++    + L+E G  + +   +I+    L++ W  I S+  +  R +  Q
Sbjct: 7395 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTE--RFSKLQ 7452

Query: 1974 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFK 2033
               ++ +T +   E     +         EI+   Q LLE ++   A +L      ++F 
Sbjct: 7453 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQ---AEMFS 7506

Query: 2034 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2093
            +++ L +I            II  ++   L+     +R +    L+ L  QW+ V +  +
Sbjct: 7507 RQQILHSI------------IIDGQR--LLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552

Query: 2094 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF----LRKTQIPENWEHAKYKWYLKELQ 2149
             R+G  D  + +W+R+    +   +WL E        L    IP       +     + +
Sbjct: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612

Query: 2150 DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2209
              + Q+ + + T+ A G++++  +     + LQ +L  +  +W+           RLEEQ
Sbjct: 7613 VFLRQQGSYILTVEA-GKQLLLSADSGAEAALQAELAEIQEKWKSA-------SMRLEEQ 7664

Query: 2210 KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ-VKLLVEELPLRQGILK 2268
            K  L+   +D      W E+ +   +  LE  K +  K+KL Q +    EEL   Q   K
Sbjct: 7665 KKKLAFLLKD------W-EKCEKGIADSLE--KLRTFKKKLSQSLPDHHEELHAEQMRCK 7715

Query: 2269 QLNETGG------------PVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEI 2316
            +L    G               +SA IS ++   L  +++    QW ++   L  ++ +I
Sbjct: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775

Query: 2317 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSP-----IRNQLEIYNQPNQEGPFDVQETEIA 2371
              ++ +     +K ++L E L  +   +S      I   +E   +  QE     QE +I 
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ 7835

Query: 2372 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2431
            +Q     + E L+K  H   E  A++ ++ KL  ++  W+    LL  + A+   L    
Sbjct: 7836 LQ----QMGERLAKASH---ESKASE-IEYKLGKVNDRWQ---HLLDLIAARVKKL---- 7880

Query: 2432 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2491
                                KET +              A+   ++  + L  WL+ ++ 
Sbjct: 7881 --------------------KETLV--------------AVQQLDKNMSSLRTWLAHIES 7906

Query: 2492 VIKSQRVMVG-DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK---NKTSNQEAR 2547
             +    V    + E+I   + +Q+   +D+E+    +  ++   + L    +  +     
Sbjct: 7907 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC 7966

Query: 2548 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL--GQARAKLES 2605
              I      +  +W  +      RR ++ E  +   ++L+     E  L   +  A   S
Sbjct: 7967 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 8026

Query: 2606 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 2665
                 YTV   ++++ + +   + + +  T +++ N    +L R+   D    +  +   
Sbjct: 8027 SSGVIYTV--AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8084

Query: 2666 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 2725
             N  W ++ KRV+     L+      ++F    +  L WLTE +     ++  +  +   
Sbjct: 8085 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--- 8141

Query: 2726 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 2785
                 V+  +KQ +  Q EI  + +    +    ++++   E   DA +++  LD     
Sbjct: 8142 -----VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL-DAAIIEEELD----- 8190

Query: 2786 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 2845
              ELR+    +   +E       R H    + L+ L L DDE                  
Sbjct: 8191 --ELRRYCQEVFGRVE-------RYH----KKLIRLPLPDDE------------------ 8219

Query: 2846 DVHRAFKRELKTKEPVIMSTL----ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2901
              H    REL+ ++   +S L     +    L+ QP   L     +P       R++   
Sbjct: 8220 --HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL------RSERSG 8271

Query: 2902 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERL--QELQEATDELDLKLRQAEVIKG 2958
            R      + +  EW+    H  D  R ++  + R    E +E  D+ D  LR A  + G
Sbjct: 8272 RDTPASVDSIPLEWD----HDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG 8326



 Score =  142 bits (359), Expect = 5e-33
 Identities = 462/2419 (19%), Positives = 930/2419 (38%), Gaps = 354/2419 (14%)

Query: 259  KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 318
            + TKE   QLH    + +++T +     E   +        ++  +     +    S + 
Sbjct: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687

Query: 319  SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 376
            +  L+  E   F    +E E+ +L+  +++L     W  S     +      + V+ V  
Sbjct: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743

Query: 377  -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 433
              +  T E  + D+      + +  + G + +   +  E E    E+ + M  L      
Sbjct: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803

Query: 434  LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 493
            +R   M  +  LH  L    + K K L  W+ + +E     EE  +  +L + K Q+ ++
Sbjct: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859

Query: 494  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
            K LQ+ +   +  V S+            +   A LE                      L
Sbjct: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886

Query: 554  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612
            +QD+ LK  ++ + Q  +    S  ++ V  +     KD  +  S LQ       ++EK 
Sbjct: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937

Query: 613  KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 669
              Q  G+L +   DLL T   +++TQ+    +A ++  A   D L     K    I Q  
Sbjct: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995

Query: 670  TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723
               Q  L Q          ++ + + +  Q + +  + EL        RQ T+       
Sbjct: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046

Query: 724  LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 782
                  +  +W++  +  L+ SP+  + R E           AI++ K   FR LQ+ +R
Sbjct: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087

Query: 783  SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 837
            +   L+  M +         A  I+Q  + +  + ++   L      W E ++     + 
Sbjct: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144

Query: 838  QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 897
             LQ  +Q     +     +  +  E    ++ +   KD V +L   Q  +  +  +   L
Sbjct: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199

Query: 898  KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 955
             +K + P   +       NH    + D+  Q+    LQ   D      Y + M+ +  ++
Sbjct: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253

Query: 956  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015
            ++  T+     L+ +D E     L  L+ L  +LQE++  +  L    ++M +    +  
Sbjct: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311

Query: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
               + +   +E RW +L   +    Q     + +L  +Q+  Q L +W  E    + E  
Sbjct: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371

Query: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135
                  ++ +  L     + S+++  Q  L S+ +   ++  +        ++  L +  
Sbjct: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431

Query: 1136 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1195
            +  + +   V  R++ L   L +       + +    + Q E + + R+     PD++ K
Sbjct: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491

Query: 1196 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1248
             V+  K A       +A +K     V  + AQ   + +E  ++E       L+ L + Y 
Sbjct: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544

Query: 1249 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1308
             +  + + + + LE+            +KA  WL + +       N+   + E+   L  
Sbjct: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604

Query: 1309 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1352
             +N++  S +  N +  L +T           D   + E +N     FN        ++ 
Sbjct: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664

Query: 1353 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1395
            ++ E  + R++   L+E + QS  E E              ++E+L+  D   A     A
Sbjct: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724

Query: 1396 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1431
             + + VD     +E      Q  Q D   H ++L                      ++H 
Sbjct: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784

Query: 1432 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1485
            +  +  +R L  +   Q K+ + ++    K +++   A     LQ+S ++L  V +HL  
Sbjct: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841

Query: 1486 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1539
              P L+  + E  +  +QS       L  ++ E  +E E       ++VQ    QTE  +
Sbjct: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895

Query: 1540 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1584
             LD   RV A       L L+  ++     K+   +++++  L++   +    KE     
Sbjct: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955

Query: 1585 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1642
            + L + D+E  L + S ++G   ++   +   +AT  EI  Q    +   +V +A    L
Sbjct: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009

Query: 1643 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1702
               + L++     L  N + V S AEE L   +E+    + F  N++ +   +   D L+
Sbjct: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063

Query: 1703 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1759
                  KP  KED+ +++ + EL   R   DS    D      A   D+ +K  E  I  
Sbjct: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116

Query: 1760 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1815
            +N     +S    +KT  +     E E+  S+ + L+  + +  ++ V L+E+     K 
Sbjct: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172

Query: 1816 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1875
             N+ ++ T+   +     + QR T  R R   + ++++L+   +      + + KKA E+
Sbjct: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILEDAVDEWTGF-NNKVKKATEM 5226

Query: 1876 SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEG 1935
              Q  Q K       K     + +L +L E  D   +     EL++++  L  +R+Q   
Sbjct: 5227 IDQ-LQDKLPGSSAEKA---SKAELLTLLEYHDTFVL-----ELEQQQSALGMLRQQTLS 5277

Query: 1936 LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 1995
            + +DGAA    PT  +     +EI +   Q R LN  +   V+    +V  E    E+  
Sbjct: 5278 MLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQELKDREM-- 5327

Query: 1996 VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 2055
                  T+I  V   + E ++ L  P +   + +   ++ + L     + +Q+  ++   
Sbjct: 5328 ----VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQNIEKMAEE 5380

Query: 2056 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI-K 2114
              +K   L +  P E + LQ A   LD    K+    +D+    ++S    +     I K
Sbjct: 5381 QKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQELSRQIQK 5436

Query: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
            +     T   +   KT   +N   AK  +  L E  DG   +   +  L+A  ++ ++Q+
Sbjct: 5437 LAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAAVQKFLEQN 5490

Query: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI 2233
             +     L +K+G L    Q+  +Q  +R  +L +  + L E+   L   + W+E+A  +
Sbjct: 5491 GQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVL 5549

Query: 2234 ASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLEN 2293
            A   +      QL+E+    + L+EE       L+ + E      +    S    +K+  
Sbjct: 5550 AHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSVYCTEKMSQ 5604

Query: 2294 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2353
            ++ +   +  ++ + +  +   ++   KD+ + E +L+ L+  L                
Sbjct: 5605 QVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE--------------- 5649

Query: 2354 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2413
                        Q T  + +  +  ++E LS  QHL  E          +E L  + +AV
Sbjct: 5650 ----------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MESLKPKVQAV 5689

Query: 2414 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2473
                  LR  + D+   L    A+    + L  +    + TAI +  +  + +++     
Sbjct: 5690 QLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAAVVQ---YE 5741

Query: 2474 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 2533
             + +    L   +    + I+ + V   +++++   I + +   Q ++  + Q+  L + 
Sbjct: 5742 QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801

Query: 2534 AQNLKNKTSNQEARTIITD 2552
             + L  K  +      +T+
Sbjct: 5802 CKMLTMKAKHATMLLTVTE 5820



 Score =  119 bits (298), Expect = 6e-26
 Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)

Query: 949  SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1008
            S +++W+ +   + S+ QL       +E          S   EQ    Y +     EM  
Sbjct: 521  SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571

Query: 1009 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
            KA   +  +        E   +W+ LS ++      LEE ++   +  N + +L+ W+ +
Sbjct: 572  KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631

Query: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1126
             +  L +       SE  KK     R L   IQ       ++N+ G  +    +   +  
Sbjct: 632  AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678

Query: 1127 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180
            L+ +L  LN +W  +  +V  YA+ + +    K   +  V+L    +E H+ ++    E 
Sbjct: 679  LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734

Query: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1233
            LE  F       ++  +++++  ++     +A+ K++T++ + +  ++P           
Sbjct: 735  LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789

Query: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1286
              LK++L  +   Y  L          LEE+          L K N+ +  +E       
Sbjct: 790  SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849

Query: 1287 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1332
             FK K             T   I  G++ + + + +L N+++H +    Q +I    +  
Sbjct: 850  LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908

Query: 1333 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1387
              ++ +  +  + +ET +   ++  E     +K+L   ++ ++   + E+ L    E  +
Sbjct: 909  QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968

Query: 1388 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1444
             +D++ L A++   D++      QE Q +Q  +      L +  K  QG+     +  +I
Sbjct: 969  QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024

Query: 1445 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1495
            DV + +          ++  + +L  +  + E+ ++E ++   D+   HL     + +E+
Sbjct: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083

Query: 1496 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1550
              V+  +   V       + +L E+++ ++   +        K  E+P +  +  +    
Sbjct: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131

Query: 1551 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1607
             ++E  + ++  + QL+  K   +      E+    E +      +TKR   +  + S L
Sbjct: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188

Query: 1608 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1667
              +V    +++ E +KQ   L  ++   +AL T+L + E ++ +    +    I V +  
Sbjct: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245

Query: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1727
            EE ++   E Q+  E         T+ + +A  LL   ++K         KR+ A+  D+
Sbjct: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292

Query: 1728 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1778
            + ++   +     L     +  RKL        +  E   R   ++     R +T K ++
Sbjct: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352

Query: 1779 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833
             ++ L Q  S  ++ L     E L +E++Q     +   +  +  +N       +  G  
Sbjct: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411

Query: 1834 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1893
             +Q +  + K     IK+Q+ + +    +D+++    K      +W  +    + L   +
Sbjct: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462

Query: 1894 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1951
             + EK+L +L       + +I +I   +Q+ + +L+++     GL E+  + A    Q  
Sbjct: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514

Query: 1952 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2011
             +     I++K  Q RR        +RE    +  E   L        +   +  + Q++
Sbjct: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568

Query: 2012 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2070
             E E  L  P        + +K  +   ++  +L+  S  I       TA   SA  V  
Sbjct: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621

Query: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2130
            R    +  + L  Q+E + +  K+RQ   +  +  W+R   ++  F  WL   E      
Sbjct: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681

Query: 2131 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2187
            ++  + +  K +  L   + LQ+ +  + +    L    E +   +SK D  +++  L  
Sbjct: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741

Query: 2188 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2243
            L+ RW+++ + ++ R   L+       +F   L  F +W    L E    + I +   + 
Sbjct: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801

Query: 2244 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2301
               + K+   +V+    EL   QG L +L   G           E+   L+ K +     
Sbjct: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852

Query: 2302 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2360
            + + S+ +  +Q  + + + +  Q    L  +  QL   +   + + +N+ ++  +    
Sbjct: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910

Query: 2361 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2418
               D  +   A+++    ++ ILSK Q+  K   + Q    +   + L  E + +  LL 
Sbjct: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967

Query: 2419 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2478
              +++   LA           + +  +    + + T   +L+ P+   L+   L  FN+ 
Sbjct: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024

Query: 2479 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2527
              EL        WL     Q+ +       +++ +IN + +    T + + + + Q   L
Sbjct: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084

Query: 2528 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2570
             +L+   QNLK+  S   + A ++I  R                E  +N+ +  Q+ L N
Sbjct: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144

Query: 2571 ----RRQQLNEMLK