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Search of human proteins with 4826878
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
(527 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 1039 0.0
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 761 0.0
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 239 6e-63
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 235 7e-62
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 235 7e-62
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 226 5e-59
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 201 1e-51
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 199 4e-51
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 198 1e-50
gi|32483399 p21-activated kinase 2 [Homo sapiens] 194 2e-49
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 194 2e-49
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 193 3e-49
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 193 3e-49
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 193 3e-49
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 193 3e-49
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 193 3e-49
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 193 3e-49
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 193 4e-49
gi|145275208 myosin IIIA [Homo sapiens] 191 1e-48
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 189 4e-48
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 189 4e-48
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 189 4e-48
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 189 4e-48
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 189 4e-48
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 189 4e-48
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 189 4e-48
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 189 4e-48
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 189 4e-48
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 186 3e-47
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 183 3e-46
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 1039 bits (2687), Expect = 0.0
Identities = 527/527 (100%), Positives = 527/527 (100%)
Query: 1 MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL 60
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL
Sbjct: 1 MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL 60
Query: 61 LKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDE 120
LKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDE
Sbjct: 61 LKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDE 120
Query: 121 STIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRN 180
STIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRN
Sbjct: 121 STIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRN 180
Query: 181 KVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL 240
KVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL
Sbjct: 181 KVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL 240
Query: 241 QNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFL 300
QNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFL
Sbjct: 241 QNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFL 300
Query: 301 QEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
QEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP
Sbjct: 301 QEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Query: 361 RVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQA 420
RVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQA
Sbjct: 361 RVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQA 420
Query: 421 LSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLV 480
LSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLV
Sbjct: 421 LSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLV 480
Query: 481 IVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS 527
IVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Sbjct: 481 IVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS 527
>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
[Homo sapiens]
Length = 545
Score = 761 bits (1964), Expect = 0.0
Identities = 389/523 (74%), Positives = 446/523 (85%), Gaps = 28/523 (5%)
Query: 5 SSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEI 64
+ A+ W I RD YELQEVIGSGATAVVQAA C P++E+VAIKRINLEKCQTSMDELLKEI
Sbjct: 51 AQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEI 110
Query: 65 QAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIA 124
QAMSQC HPN+V+YYTSFVVKDELWLVMKLLSGGS+LDIIK+IV +GEHK+GVL+E+ IA
Sbjct: 111 QAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIA 170
Query: 125 TILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRK 184
TIL+EVLEGL+YLH+NGQIHRD+KAGNILLGEDGSVQIADFGVSAFLATGGD+TRNKVRK
Sbjct: 171 TILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRK 230
Query: 185 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 244
TFVGTPCWMAPEVMEQVRGYDFKAD+WSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP
Sbjct: 231 TFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 290
Query: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKT 304
P+LETGV+DKEM+KKYGKSFRK++SLCLQKDP KRPTAAELL+ KFFQKAKN+E+L EK
Sbjct: 291 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKL 350
Query: 305 LQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKE 364
L R P I++RAKKVRRVPGSSG LHKTEDG WEWSDDE DE+SEEGKAA SQ +S RVKE
Sbjct: 351 LTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKE 410
Query: 365 SISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSG 424
N E+ + +PEQI + ++ +Q PP A +
Sbjct: 411 --ENPEIAVSAS------TIPEQIQS--------LSVHDSQG--PPNA----------NE 442
Query: 425 SGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAA 484
+ + ++LVLRLRNS+KELNDIRFEFTPGRDTA+GVSQEL SAGLVDG D+VIVAA
Sbjct: 443 DYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAA 502
Query: 485 NLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS 527
NLQKIV++P++ +++TFKLASG +GS+IPD+ KLIGFAQLS+S
Sbjct: 503 NLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS 545
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 239 bits (609), Expect = 6e-63
Identities = 145/347 (41%), Positives = 200/347 (57%), Gaps = 48/347 (13%)
Query: 23 IGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSF 82
IG G+ V KE VAIK I+LE+ + ++++ +EI +SQC P I Y+ S+
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 83 VVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQ 142
+ +LW++M+ L GGS LD++K G L+E+ IATILRE+L+GL+YLH +
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLK---------PGPLEETYIATILREILKGLDYLHSERK 136
Query: 143 IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVMEQV 201
IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++Q
Sbjct: 137 IHRDIKAANVLLSEQGDVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIKQ- 189
Query: 202 RGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYG 261
YDFKADIWS GITAIELA G P PM+VL L +N PP+LE ++
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLE---------GQHS 240
Query: 262 KSFRKMISLCLQKDPEKRPTAAELLRHKFFQK-AKNKEFLQEKTLQRAPTISERAKKVRR 320
K F++ + CL KDP RPTA ELL+HKF + K FL E + +R K+
Sbjct: 241 KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTE--------LIDRYKR--- 289
Query: 321 VPGSSGRLHKTEDGGWEWS--DDEFDEESEEGKAAISQLRSPRVKES 365
K+E G E S D + D E+E+G+ P ++ S
Sbjct: 290 --------WKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPS 328
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 235 bits (600), Expect = 7e-62
Identities = 154/413 (37%), Positives = 225/413 (54%), Gaps = 54/413 (13%)
Query: 21 EVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYT 80
E IG G+ V ++ VAIK I+LE+ + ++++ +EI +SQC P + YY
Sbjct: 28 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 87
Query: 81 SFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKN 140
S++ +LW++M+ L GGS LD+++ G LDE+ IATILRE+L+GL+YLH
Sbjct: 88 SYLKDTKLWIIMEYLGGGSALDLLE---------PGPLDETQIATILREILKGLDYLHSE 138
Query: 141 GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVME 199
+IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIK 192
Query: 200 QVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKK 259
Q YD KADIWS GITAIELA G P+ + PMKVL L +N+PP+LE
Sbjct: 193 Q-SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE---------GN 242
Query: 260 YGKSFRKMISLCLQKDPEKRPTAAELLRHKF-FQKAKNKEFLQEKTLQRAPTISERAKKV 318
Y K ++ + CL K+P RPTA ELL+HKF + AK +L E + +R K+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTE--------LIDRYKRW 294
Query: 319 RRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKE--SISNSELFPTTD 376
+ +D E SD E D ++ G + + + R K+ ++ N L P+
Sbjct: 295 KAE-------QSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDL 347
Query: 377 PVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQE 429
+ +P+ +P Q + + P AE + +QA GS E
Sbjct: 348 DRNKMKDIPK-------RPFSQCL---STIISPLFAELKEKSQACGGNLGSIE 390
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 235 bits (600), Expect = 7e-62
Identities = 154/413 (37%), Positives = 225/413 (54%), Gaps = 54/413 (13%)
Query: 21 EVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYT 80
E IG G+ V ++ VAIK I+LE+ + ++++ +EI +SQC P + YY
Sbjct: 40 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 99
Query: 81 SFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKN 140
S++ +LW++M+ L GGS LD+++ G LDE+ IATILRE+L+GL+YLH
Sbjct: 100 SYLKDTKLWIIMEYLGGGSALDLLE---------PGPLDETQIATILREILKGLDYLHSE 150
Query: 141 GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVME 199
+IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIK 204
Query: 200 QVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKK 259
Q YD KADIWS GITAIELA G P+ + PMKVL L +N+PP+LE
Sbjct: 205 Q-SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE---------GN 254
Query: 260 YGKSFRKMISLCLQKDPEKRPTAAELLRHKF-FQKAKNKEFLQEKTLQRAPTISERAKKV 318
Y K ++ + CL K+P RPTA ELL+HKF + AK +L E + +R K+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTE--------LIDRYKRW 306
Query: 319 RRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKE--SISNSELFPTTD 376
+ +D E SD E D ++ G + + + R K+ ++ N L P+
Sbjct: 307 KAE-------QSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDL 359
Query: 377 PVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQE 429
+ +P+ +P Q + + P AE + +QA GS E
Sbjct: 360 DRNKMKDIPK-------RPFSQCL---STIISPLFAELKEKSQACGGNLGSIE 402
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 226 bits (575), Expect = 5e-59
Identities = 126/284 (44%), Positives = 176/284 (61%), Gaps = 27/284 (9%)
Query: 21 EVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYT 80
E IG G+ V ++ VAIK I+LE+ + ++++ +EI +SQC + YY
Sbjct: 28 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG 87
Query: 81 SFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKN 140
S++ +LW++M+ L GGS LD+++ +G DE IAT+L+E+L+GL+YLH
Sbjct: 88 SYLKGSKLWIIMEYLGGGSALDLLR---------AGPFDEFQIATMLKEILKGLDYLHSE 138
Query: 141 GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVME 199
+IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIQ 192
Query: 200 QVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKK 259
Q YD KADIWS GITAIELA G P PM+VL L +N+PP+L +
Sbjct: 193 Q-SAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL---------VGD 242
Query: 260 YGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK-AKNKEFLQE 302
+ KSF++ I CL KDP RPTA ELL+HKF K +K +L E
Sbjct: 243 FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTE 286
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 201 bits (512), Expect = 1e-51
Identities = 114/287 (39%), Positives = 166/287 (57%), Gaps = 25/287 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
+++ E +G G+ V A + VAIK++ +E + + E++KEI M QC P++V
Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE---SDLQEIIKEISIMQQCDSPHVV 86
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
YY S+ +LW+VM+ GSV DII+ ++ L E IATIL+ L+GLEY
Sbjct: 87 KYYGSYFKNTDLWIVMEYCGAGSVSDIIR-------LRNKTLTEDEIATILQSTLKGLEY 139
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAP 195
LH +IHRD+KAGNILL +G ++ADFGV+ G +T R T +GTP WMAP
Sbjct: 140 LHFMRKIHRDIKAGNILLNTEGHAKLADFGVA------GQLTDTMAKRNTVIGTPFWMAP 193
Query: 196 EVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKE 255
EV++++ GY+ ADIWS GITAIE+A G PY PM+ + + N PP+
Sbjct: 194 EVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKP----- 247
Query: 256 MLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQE 302
+ + +F + CL K PE+R TA +LL+H F + AK L++
Sbjct: 248 --ELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRD 292
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 199 bits (507), Expect = 4e-51
Identities = 123/352 (34%), Positives = 191/352 (54%), Gaps = 35/352 (9%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
+++ E +G G+ V A + VAIK++ +E + + E++KEI M QC P +V
Sbjct: 27 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPYVV 83
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
YY S+ +LW+VM+ GSV DII+ ++ L E IATIL+ L+GLEY
Sbjct: 84 KYYGSYFKNTDLWIVMEYCGAGSVSDIIR-------LRNKTLIEDEIATILKSTLKGLEY 136
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAP 195
LH +IHRD+KAGNILL +G ++ADFGV+ G +T R T +GTP WMAP
Sbjct: 137 LHFMRKIHRDIKAGNILLNTEGHAKLADFGVA------GQLTDTMAKRNTVIGTPFWMAP 190
Query: 196 EVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKE 255
EV++++ GY+ ADIWS GIT+IE+A G PY PM+ + + N PP+
Sbjct: 191 EVIQEI-GYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKP----- 244
Query: 256 MLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERA 315
+ + F + CL K+PE+R TA +LL+H F + AK L++ + ++R
Sbjct: 245 --ELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRH 302
Query: 316 KKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESIS 367
++ +R L + E+ +DE D + K ++ + + R ++S
Sbjct: 303 EEQQR------ELEEEEENS---DEDELDSHTMV-KTSVESVGTMRATSTMS 344
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 198 bits (503), Expect = 1e-50
Identities = 115/279 (41%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 328
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ LE+
Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALEF 379
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 380 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 434
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L+
Sbjct: 435 VVTR-KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP------ 487
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
+K FR ++ CL+ D EKR +A ELL+H+F + AK
Sbjct: 488 -EKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAK 525
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 194 bits (492), Expect = 2e-49
Identities = 113/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK+INL+K Q + ++ EI M + +PNIV
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK-QPKKELIINEILVMKELKNPNIV 307
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
++ S++V DEL++VM+ L+GGS+ D++ +DE+ IA + RE L+ LE+
Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVTETC---------MDEAQIAAVCRECLQALEF 358
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ N+LLG +GSV++ DFG A + R T VGTP WMAPE
Sbjct: 359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 413
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L+
Sbjct: 414 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP------ 466
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
+K FR ++ CL+ D EKR +A ELL+H F + AK
Sbjct: 467 -EKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 504
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 194 bits (492), Expect = 2e-49
Identities = 119/281 (42%), Positives = 166/281 (59%), Gaps = 25/281 (8%)
Query: 14 RDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHP 73
++D+EL + IGSG V A E AIK I LE + + +EI M C HP
Sbjct: 13 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGE-DFAVVQQEIIMMKDCKHP 71
Query: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
NIV+Y+ S++ +D+LW+ M+ GGS+ DI H +G L E IA + RE L+G
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIY--------HVTGPLSELQIAYVSRETLQG 123
Query: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193
L YLH G++HRD+K NILL ++G V++ADFGVSA + I + RK+F+GTP WM
Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQIT--ATIAK---RKSFIGTPYWM 178
Query: 194 APEV--MEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND--PPSLET 249
APEV +E+ GY+ D+W+ GITAIELA P PM+ L L +++ PP L
Sbjct: 179 APEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL-- 236
Query: 250 GVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKF 290
+DK K+ SF + + L K+P+KRPTA +LL+H F
Sbjct: 237 --KDK---MKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPF 272
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 193 bits (491), Expect = 3e-49
Identities = 114/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 341
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ L++
Sbjct: 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALDF 392
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 393 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 447
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L Q+ E
Sbjct: 448 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL----QNPER 502
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
L FR ++ CL+ D ++R +A ELL+H F + AK
Sbjct: 503 LSAV---FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 538
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 193 bits (491), Expect = 3e-49
Identities = 114/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 289 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 347
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ L++
Sbjct: 348 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALDF 398
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 399 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 453
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L Q+ E
Sbjct: 454 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL----QNPER 508
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
L FR ++ CL+ D ++R +A ELL+H F + AK
Sbjct: 509 LSAV---FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 544
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 193 bits (491), Expect = 3e-49
Identities = 114/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 304 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 362
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ L++
Sbjct: 363 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALDF 413
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 414 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 468
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L Q+ E
Sbjct: 469 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL----QNPER 523
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
L FR ++ CL+ D ++R +A ELL+H F + AK
Sbjct: 524 LSAV---FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 559
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 193 bits (491), Expect = 3e-49
Identities = 114/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 268 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 326
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ L++
Sbjct: 327 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALDF 377
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 432
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L Q+ E
Sbjct: 433 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL----QNPER 487
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
L FR ++ CL+ D ++R +A ELL+H F + AK
Sbjct: 488 LSAV---FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 193 bits (491), Expect = 3e-49
Identities = 114/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 268 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 326
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ L++
Sbjct: 327 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALDF 377
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 432
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L Q+ E
Sbjct: 433 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL----QNPER 487
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
L FR ++ CL+ D ++R +A ELL+H F + AK
Sbjct: 488 LSAV---FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 193 bits (491), Expect = 3e-49
Identities = 114/279 (40%), Positives = 160/279 (57%), Gaps = 23/279 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 268 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 326
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ L++
Sbjct: 327 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALDF 377
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 432
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L Q+ E
Sbjct: 433 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL----QNPER 487
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
L FR ++ CL+ D ++R +A ELL+H F + AK
Sbjct: 488 LSAV---FRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 193 bits (490), Expect = 4e-49
Identities = 106/218 (48%), Positives = 141/218 (64%), Gaps = 27/218 (12%)
Query: 87 ELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRD 146
+LW++M+ L GGS LD+++ +G DE IAT+L+E+L+GL+YLH +IHRD
Sbjct: 17 KLWIIMEYLGGGSALDLLR---------AGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
Query: 147 VKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVMEQVRGYD 205
+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++Q YD
Sbjct: 68 IKAANVLLSEQGDVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIQQ-SAYD 120
Query: 206 FKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFR 265
KADIWS GITAIELA G P PM+VL L +N+PP+L + + KSF+
Sbjct: 121 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL---------VGDFTKSFK 171
Query: 266 KMISLCLQKDPEKRPTAAELLRHKFFQK-AKNKEFLQE 302
+ I CL KDP RPTA ELL+HKF K +K +L E
Sbjct: 172 EFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTE 209
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 191 bits (486), Expect = 1e-48
Identities = 121/301 (40%), Positives = 165/301 (54%), Gaps = 28/301 (9%)
Query: 15 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRIN-LEKCQTSMDELLKEIQAMSQCHHP 73
D +E+ E IG G V +K A+K ++ + ++ ++A+S HP
Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSD--HP 76
Query: 74 NIVSYYTSFVVKDE-----LWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 128
N+V +Y + KD+ LWLV++L SGGSV D++K + +GE S E IA IL
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMS----EPLIAYILH 132
Query: 129 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 188
E L GL++LH N IHRDVK NILL +G V++ DFGVSA L + TR++ R T VG
Sbjct: 133 EALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTS----TRHR-RNTSVG 187
Query: 189 TPCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 244
TP WMAPEV+ + YD + D WS GITAIEL G P PM+ L +N P
Sbjct: 188 TPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPP 247
Query: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKT 304
P L + + F IS CL KD EKRPT +ELL+HKF + + K+ + +K
Sbjct: 248 PKL-------RQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQ 300
Query: 305 L 305
L
Sbjct: 301 L 301
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 189 bits (481), Expect = 4e-48
Identities = 111/271 (40%), Positives = 154/271 (56%), Gaps = 23/271 (8%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 76
Y E IG GA+ V A ++VAIK++NL++ Q + ++ EI M + +PNIV
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIV 328
Query: 77 SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 136
+Y S++V DELW+VM+ L+GGS+ D++ +DE IA + RE L+ LE+
Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---------MDEGQIAAVCRECLQALEF 379
Query: 137 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 196
LH N IHRD+K+ NILLG DGSV++ DFG A + R T VGTP WMAPE
Sbjct: 380 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-----PEQSKRSTMVGTPYWMAPE 434
Query: 197 VMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 256
V+ + + Y K DIWS GI AIE+ G PY P++ L L N P L+
Sbjct: 435 VVTR-KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP------ 487
Query: 257 LKKYGKSFRKMISLCLQKDPEKRPTAAELLR 287
+K FR ++ CL+ D EKR +A ELL+
Sbjct: 488 -EKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 189 bits (481), Expect = 4e-48
Identities = 131/355 (36%), Positives = 189/355 (53%), Gaps = 45/355 (12%)
Query: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ-CHHPNI 75
+EL E++G+G V + AIK +++ + +E+ +EI + + HH NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNI 82
Query: 76 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 129
+YY +F+ K D+LWLVM+ GSV D+IK+ K L E IA I RE
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT------KGNTLKEEWIAYICRE 136
Query: 130 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA L D T + R TF+GT
Sbjct: 137 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGR-RNTFIGT 191
Query: 190 PCWMAPEVM----EQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP 245
P WMAPEV+ YDFK+D+WS GITAIE+A GA P PM+ L L +N P
Sbjct: 192 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAP 251
Query: 246 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTL 305
L++ KK+ K F+ I CL K+ +RP +L++H F + N+ ++ +
Sbjct: 252 RLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE---RQVRI 300
Query: 306 QRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSP 360
Q I +R KK R G +TE +E+S E +EE + S L P
Sbjct: 301 QLKDHI-DRTKKKR------GEKDETE---YEYSGSEEEEEENDSGEPSSILNLP 345
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 186 bits (473), Expect = 3e-47
Identities = 110/282 (39%), Positives = 163/282 (57%), Gaps = 27/282 (9%)
Query: 14 RDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHP 73
RD +EL + +G+G V A E A+K + L+ + L +EI + +C HP
Sbjct: 13 RDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGD-DISSLQQEITILRECRHP 71
Query: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
N+V+Y S++ D LW+ M+ GGS+ +I H +G L+E IA + RE L+G
Sbjct: 72 NVVAYIGSYLRNDRLWICMEFCGGGSLQEIY--------HATGPLEERQIAYVCREALKG 123
Query: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCW 192
L +LH G+IHRD+K N+LL G V++ADFGVS G++T + R++F+GTP W
Sbjct: 124 LHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVS------GELTASVAKRRSFIGTPYW 177
Query: 193 MAPEV--MEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN--DPPSLE 248
MAPEV +E+ GY+ D+W+ GITAIEL P PM+ LML ++ PP L
Sbjct: 178 MAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL- 236
Query: 249 TGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKF 290
+DK ++ ++F + L L K+P+KRPTA +LL+H F
Sbjct: 237 ---RDK---TRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF 272
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 183 bits (465), Expect = 3e-46
Identities = 113/281 (40%), Positives = 160/281 (56%), Gaps = 25/281 (8%)
Query: 14 RDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHP 73
+ DYEL + +GSG V A E A+K I LE + +EI + +C H
Sbjct: 17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-DFSLIQQEIFMVKECKHC 75
Query: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
NIV+Y+ S++ +++LW+ M+ GGS+ DI H +G L E IA + RE L+G
Sbjct: 76 NIVAYFGSYLSREKLWICMEYCGGGSLQDIY--------HVTGPLSELQIAYVCRETLQG 127
Query: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193
L YLH G++HRD+K NILL + G V++ADFGV+A + I + RK+F+GTP WM
Sbjct: 128 LAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT--ATIAK---RKSFIGTPYWM 182
Query: 194 APEV--MEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND--PPSLET 249
APEV +E+ GY+ DIW+ GITAIEL P PM+ L L +++ PP L
Sbjct: 183 APEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL-- 240
Query: 250 GVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKF 290
+DK K+ +F + + L K+P+KRPTA LL H F
Sbjct: 241 --KDK---TKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,060,329
Number of Sequences: 37866
Number of extensions: 918490
Number of successful extensions: 5753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 735
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 3018
Number of HSP's gapped (non-prelim): 1116
length of query: 527
length of database: 18,247,518
effective HSP length: 107
effective length of query: 420
effective length of database: 14,195,856
effective search space: 5962259520
effective search space used: 5962259520
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.